TY - JOUR T1 - Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells AN - 19467639; 7938277 AB - Tumor immunology fundamentals suggest immunological surveillance has the ability to recognize malignant cells and kill them before a tumor develops. However, cancer cells employ evasion mechanisms whereby the immune system may be actively suppressed or even tolerized to the tumor. Recently cancer stem cells were linked to tumor initiation and formation. However, no reports have addressed whether these cells participate in a tumor's ability to evade immune surveillance. Recently the glycoprotein CD200, expressed within the innate immune system and other tissues and cells, was shown to be involved in tolerance. Here we describe CD200 co-expression with stem cell markers found on prostate, breast, brain, and colon cancers. This is the first report describing an immunomodulatory molecule on epithelial cancer stem cells. This important finding suggests a mechanism by which a tumor might evades immune system detection. JF - Biochemical and Biophysical Research Communications AU - Kawasaki, B T AU - Mistree, T AU - Hurt, E M AU - Kalathur, M AU - Farrar, W L AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health Frederick, 1050 Boyles Street, Building 560, Room 21-81, MD 21702, USA, kawasakib@mail.nih.gov Y1 - 2007/12/28/ PY - 2007 DA - 2007 Dec 28 SP - 778 EP - 782 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 4 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - CD200 antigen KW - Immunosurveillance KW - Immune system KW - Brain KW - Tumors KW - Glycoproteins KW - Colon cancer KW - Prostate KW - Immunological tolerance KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Co-expression+of+the+toleragenic+glycoprotein%2C+CD200%2C+with+markers+for+cancer+stem+cells&rft.au=Kawasaki%2C+B+T%3BMistree%2C+T%3BHurt%2C+E+M%3BKalathur%2C+M%3BFarrar%2C+W+L&rft.aulast=Kawasaki&rft.aufirst=B&rft.date=2007-12-28&rft.volume=364&rft.issue=4&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Stem cells; CD200 antigen; Immunosurveillance; Immune system; Brain; Colon cancer; Glycoproteins; Tumors; Immunological tolerance; Prostate DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.067 ER - TY - JOUR T1 - Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells. AN - 69065348; 18067864 AB - Early growth response-1 (Egr-1) is involved in the regulation of cell growth. Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells. Suppression of PMA-induced Egr-1 was dependent on the expression level of PLD isozymes. Overexpression of catalytically inactive PLD, treatment with PA, and prevention of PA dephosphorylation by 1-propranolol significantly suppressed PMA-induced Egr-1 expression. PLD-induced suppression of Egr-1 was reversed by inhibition of phosphatidylinositol 3-kinase (PI3K). Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA-induced Egr-1 expression via PI3K pathway. JF - FEBS letters AU - Ahn, Bong-Hyun AU - Park, Mi Hee AU - Lee, Young Han AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute, NIH Bldg 10/CRC 5-3288, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/12/22/ PY - 2007 DA - 2007 Dec 22 SP - 5940 EP - 5944 VL - 581 IS - 30 SN - 0014-5793, 0014-5793 KW - EGR1 protein, human KW - 0 KW - Early Growth Response Protein 1 KW - Isoenzymes KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Phospholipase D KW - EC 3.1.4.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Genes, Reporter KW - Transcriptional Activation -- drug effects KW - Cell Line, Tumor KW - Response Elements KW - Isoenzymes -- metabolism KW - Phospholipase D -- metabolism KW - Glioma -- pathology KW - Early Growth Response Protein 1 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Early Growth Response Protein 1 -- genetics KW - Glioma -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69065348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Phorbol+myristate+acetate-induced+Egr-1+expression+is+suppressed+by+phospholipase+D+isozymes+in+human+glioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BPark%2C+Mi+Hee%3BLee%2C+Young+Han%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2007-12-22&rft.volume=581&rft.issue=30&rft.spage=5940&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-05 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. AN - 69081849; 18154267 AB - Activation of the signal transducer and activator of transcription 3 (STAT3) is frequently detected in many cancer types. Activated STAT3 may participate in oncogenesis by stimulating cell proliferation and resisting apoptosis, as well as promoting tumor angiogenesis, invasion, and migration. Many STAT3-dependent cellular responses are mediated through interactions with other proteins, and the amino-terminal domain (N-domain) of STAT3 was proposed to be responsible for this. Our NMR studies revealed that synthetic analogs of the STAT4 second alpha-helix bind to the N-domain and perturb its structure. Structural data available for the STAT4 N-domain was used for the rational design of STAT3 helix 2 analogs with enhanced biological activity. Cell-permeable derivatives of the STAT3 second helix were found to directly and specifically bind to STAT3 but not STAT1 as determined by FRET analysis in cells expressing GFP-STAT3 and GFP-STAT1. Furthermore, they potently induced apoptotic death in breast cancer cells but not normal breast cells or STAT3-deficient fibroblasts. The inhibitors caused significant changes in the mitochondrial potential of cancer cells, leading to cell death. These compounds not only are promising drug candidates but also offer a convenient tool for studying the mechanisms of action of STAT transcription factors and have facilitated our understanding of the crucial role of the N-domain in STAT3 function. JF - ACS chemical biology AU - Timofeeva, Olga A AU - Gaponenko, Vadim AU - Lockett, Stephen J AU - Tarasov, Sergey G AU - Jiang, Sheng AU - Michejda, Christopher J AU - Perantoni, Alan O AU - Tarasova, Nadya I AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, NCI-Frederick, Maryland 21702, USA. Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 799 EP - 809 VL - 2 IS - 12 KW - Antineoplastic Agents KW - 0 KW - STAT3 Transcription Factor KW - Index Medicus KW - Cell Survival -- drug effects KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Protein Structure, Tertiary KW - STAT3 Transcription Factor -- antagonists & inhibitors KW - Antineoplastic Agents -- toxicity KW - STAT3 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- metabolism KW - STAT3 Transcription Factor -- chemistry KW - Antineoplastic Agents -- chemistry KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69081849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+chemical+biology&rft.atitle=Rationally+designed+inhibitors+identify+STAT3+N-domain+as+a+promising+anticancer+drug+target.&rft.au=Timofeeva%2C+Olga+A%3BGaponenko%2C+Vadim%3BLockett%2C+Stephen+J%3BTarasov%2C+Sergey+G%3BJiang%2C+Sheng%3BMichejda%2C+Christopher+J%3BPerantoni%2C+Alan+O%3BTarasova%2C+Nadya+I&rft.aulast=Timofeeva&rft.aufirst=Olga&rft.date=2007-12-21&rft.volume=2&rft.issue=12&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=ACS+chemical+biology&rft.issn=1554-8937&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fluorinated alcohol mediated displacement of the C10 acetoxy group of benzo[a]pyrene-7,8,9,10-tetrahydrotetraol tetraacetates: a new route to diol epoxide-deoxyguanosine adducts. AN - 69061447; 18047370 AB - We describe a novel trifluoroethanol (TFE) or hexafluoropropan-2-ol (HFP) mediated substitution reaction of the bay-region C10 acetoxy group in four stereoisomeric 7,8,9,10-tetraacetoxy-7,8,9,10-tetrahydrobenzo[a]pyrenes (tetraol tetraacetates, two pairs of cis and trans isomers at the 9,10 positions) by the exocyclic N2-amino group of O6-allyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3). The tetraacetates are derived from cis and trans hydrolysis of (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P DE-1) and of (+/-)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P DE-2) at C-10 followed by acetylation. Excellent yields and high regioselectivity were observed. Similar cis/trans product ratios were observed for each set of cis and trans tetraol tetraacetates derived from DE-1 ( approximately 75/25) and from DE-2 (approximately 67/33) in HFP. This strongly suggests that the substitution proceeds via an SN1 mechanism involving a carbocation intermediate that is common to the cis and trans tetraacetates. Since it is likely that the cis and trans products from 3 arise from different conformations of the carbocation, its lifetime must be sufficiently long to permit conformational equilibration before its capture by the purine nucleophile. The corresponding reaction of (+/-)-9alpha-bromo-7beta,8alpha,10beta-triacetoxy-7,8,9,10-tetrahydrobenzo[a]pyrene with 3 in HFP was highly regio- and stereoselective and gave exclusively trans 10beta-adducts. This newly developed substitution reaction provides an attractive alternative synthetic strategy for the preparation of polycyclic hydrocarbon adducted oligonucleotide building blocks. JF - The Journal of organic chemistry AU - Yagi, Haruhiko AU - Jerina, Donald M AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 9983 EP - 9990 VL - 72 IS - 26 SN - 0022-3263, 0022-3263 KW - DNA Adducts KW - 0 KW - O(6)-allyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine KW - Organosilicon Compounds KW - Propanols KW - hexafluoroisopropanol KW - 3D632GYQ50 KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Trifluoroethanol KW - 75-89-8 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Stereoisomerism KW - Molecular Conformation KW - Hydrolysis KW - Trifluoroethanol -- chemistry KW - Organosilicon Compounds -- chemistry KW - DNA Adducts -- chemistry KW - Deoxyguanosine -- chemical synthesis KW - Deoxyguanosine -- chemistry KW - DNA Adducts -- chemical synthesis KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry KW - Propanols -- chemistry KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+organic+chemistry&rft.atitle=Fluorinated+alcohol+mediated+displacement+of+the+C10+acetoxy+group+of+benzo%5Ba%5Dpyrene-7%2C8%2C9%2C10-tetrahydrotetraol+tetraacetates%3A+a+new+route+to+diol+epoxide-deoxyguanosine+adducts.&rft.au=Yagi%2C+Haruhiko%3BJerina%2C+Donald+M&rft.aulast=Yagi&rft.aufirst=Haruhiko&rft.date=2007-12-21&rft.volume=72&rft.issue=26&rft.spage=9983&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+organic+chemistry&rft.issn=00223263&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations that alter the equilibrium between open and closed conformations of Escherichia coli maltose-binding protein impede its ability to enhance the solubility of passenger proteins AN - 20397146; 7786467 AB - Certain highly soluble proteins, such as Escherichia coli maltose-binding protein (MBP), have the ability to enhance the solubility of their fusion partners, making them attractive vehicles for the production of recombinant proteins, yet the mechanism of solubility enhancement remains poorly understood. Here, we report that the solubility-enhancing properties of MBP are dramatically affected by amino acid substitutions that alter the equilibrium between its ''open'' and ''closed'' conformations. Our findings indicate that the solubility-enhancing activity of MBP is mediated by its open conformation and point to a likely role for the ligand-binding cleft in the mechanism of solubility enhancement. JF - Biochemical and Biophysical Research Communications AU - Nallamsetty, S AU - Waugh, D S AD - Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702-1201, USA, waughd@ncifcrf.gov Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 639 EP - 644 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 3 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Solubility KW - Amino acid substitution KW - Escherichia coli KW - maltose-binding protein KW - Mutation KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Mutations+that+alter+the+equilibrium+between+open+and+closed+conformations+of+Escherichia+coli+maltose-binding+protein+impede+its+ability+to+enhance+the+solubility+of+passenger+proteins&rft.au=Nallamsetty%2C+S%3BWaugh%2C+D+S&rft.aulast=Nallamsetty&rft.aufirst=S&rft.date=2007-12-21&rft.volume=364&rft.issue=3&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Solubility; maltose-binding protein; Mutation; Escherichia coli DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.060 ER - TY - JOUR T1 - Chitosan solution enhances the immunoadjuvant properties of GM-CSF. AN - 69048242; 18037196 AB - Sustained, local delivery of immunomodulatory cytokines is under investigation for its ability to enhance vaccine and anti-tumor responses both clinically and preclinically. This study evaluates the ability of chitosan, a biocompatible polysaccharide, to (1) control the dissemination of a cytokine, GM-CSF, and (2) enhance the immunoadjuvant properties of GM-CSF. While cytokines have previously been delivered in lipid-based adjuvants and other vehicles, these do not have the clinical safety profile or unique properties of chitosan. We found that chitosan solution maintained a measurable depot of recombinant GM-CSF (rGM-CSF) at a subcutaneous injection site for up to 9 days. In contrast, when delivered in a saline vehicle, rGM-CSF was undetectable in 12-24h. Furthermore, a single s.c. injection of 20 microg rGM-CSF in chitosan solution (chitosan/rGM-CSF(20 microg)) transiently expanded lymph nodes up to 4.6-fold and increased the number of MHC class II expressing cells and dendritic cells by 7.4-fold and 6.8-fold, respectively. These increases were significantly greater than those measured when rGM-CSF was administered in saline at the standard preclinical dose and schedule, i.e. 4 daily s.c. injections of 20 microg. Furthermore, lymph node cells from mice injected with chitosan/rGM-CSF(20 microg) induced greater allogeneic T cell proliferation, indicating enhanced antigen presenting capability, than lymph node cells from mice injected with rGM-CSF alone. Finally, in vaccination experiments, chitosan/rGM-CSF was superior to either chitosan or rGM-CSF alone in enhancing the induction of antigen-specific CD4(+) proliferation, peptide-specific CD8(+) pentamer staining and cytotoxic T cell lysis. Altogether, chitosan/rGM-CSF outperformed standard rGM-CSF administrations in dendritic cell recruitment, antigen presentation and vaccine enhancement. We conclude that chitosan solution is a promising delivery platform for the sustained, local delivery of rGM-CSF. JF - Vaccine AU - Zaharoff, David A AU - Rogers, Connie J AU - Hance, Kenneth W AU - Schlom, Jeffrey AU - Greiner, John W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, United States. Y1 - 2007/12/17/ PY - 2007 DA - 2007 Dec 17 SP - 8673 EP - 8686 VL - 25 IS - 52 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Delayed-Action Preparations KW - Histocompatibility Antigens Class II KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Chitosan KW - 9012-76-4 KW - Index Medicus KW - Animals KW - Dendritic Cells -- immunology KW - Histocompatibility Antigens Class II -- genetics KW - Gene Expression KW - CD4-Positive T-Lymphocytes -- immunology KW - Delayed-Action Preparations -- administration & dosage KW - T-Lymphocytes, Cytotoxic -- immunology KW - Mice KW - Cell Proliferation KW - Antigen Presentation -- immunology KW - Adjuvants, Immunologic -- administration & dosage KW - CD8-Positive T-Lymphocytes -- immunology KW - Injections, Subcutaneous KW - Lymphocyte Subsets -- immunology KW - Cytotoxicity Tests, Immunologic KW - Female KW - Lymph Nodes -- immunology KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Granulocyte-Macrophage Colony-Stimulating Factor -- immunology KW - Chitosan -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69048242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Chitosan+solution+enhances+the+immunoadjuvant+properties+of+GM-CSF.&rft.au=Zaharoff%2C+David+A%3BRogers%2C+Connie+J%3BHance%2C+Kenneth+W%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Zaharoff&rft.aufirst=David&rft.date=2007-12-17&rft.volume=25&rft.issue=52&rft.spage=8673&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Trauma. 2006 Mar;60(3):655-8 [16531872] J Pharm Sci. 2004 May;93(5):1100-9 [15067687] Vaccine. 2004 Feb 25;22(8):909-14 [15161067] Cancer Res. 2004 Sep 1;64(17):6337-43 [15342423] Blood. 1980 Dec;56(6):947-58 [7002232] J Immunol. 1987 Aug 15;139(4):1113-9 [3038997] Cancer Res. 1993 Dec 15;53(24):5841-4 [8261390] JAMA. 1994 Mar 23-30;271(12):907-13 [8120958] Cytokine. 1994 Jan;6(1):92-101 [8003640] J Clin Oncol. 1995 Mar;13(3):688-96 [7884429] Int J Cancer. 1996 Jul 3;67(1):54-62 [8690525] Blood. 1996 Jul 1;88(1):202-10 [8704175] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10972-7 [8855293] J Pharm Sci. 1996 Dec;85(12):1261-70 [8961136] Vaccine. 1996 Sep;14(13):1199-204 [8961505] Blood. 1997 Oct 1;90(7):2541-8 [9326219] Curr Opin Immunol. 2004 Feb;16(1):108-13 [14734118] Ann Surg Oncol. 2004 Feb;11(2):147-56 [14761917] Am J Clin Nutr. 2004 Apr;79(4):529-36 [15051593] Pharm Res. 1997 Oct;14(10):1422-30 [9358556] Clin Cancer Res. 1998 Aug;4(8):1881-6 [9717815] Science. 1998 Aug 21;281(5380):1161-2 [9735031] J Immunother. 1999 Mar;22(2):166-74 [10093041] J Immunol. 1999 May 15;162(10):5728-37 [10229805] J Immunol. 2005 Jan 15;174(2):898-906 [15634912] Obes Rev. 2005 Feb;6(1):35-42 [15655037] Cancer Biother Radiopharm. 2004 Dec;19(6):764-9 [15665625] J Clin Oncol. 2005 Feb 1;23(4):720-31 [15613691] Vaccine. 2005 Apr 22;23(22):2909-21 [15780740] Clin Cancer Res. 2005 May 1;11(9):3353-62 [15867235] Vaccine. 2005 Aug 15;23(35):4367-74 [15916838] J Immunother. 2006 Jan-Feb;29(1):10-20 [16365596] J Interferon Cytokine Res. 2006 Jun;26(6):380-9 [16734558] Drug Dev Ind Pharm. 2006 Jul;32(6):699-707 [16885125] J Surg Oncol. 2006 Oct 1;94(5):403-12 [16967445] Drug Dev Ind Pharm. 2003 Nov;29(10):1149-53 [14677775] J Immunol. 2006 Nov 15;177(10):6962-73 [17082611] Int Rev Immunol. 2006 Sep-Dec;25(5-6):321-52 [17169779] J Immunol. 2007 Feb 15;178(4):2182-91 [17277123] Ann Oncol. 2007 Feb;18(2):226-32 [17116643] Vaccine. 2007 Mar 1;25(11):2085-94 [17258843] J Immunother. 1999 Nov;22(6):525-38 [10570751] Pharm Res. 2000 Jan;17(1):42-8 [10714607] Pharm Res. 2000 Jan;17(1):100-6 [10714616] J Immunother. 2000 Mar-Apr;23(2):190-5 [10746545] Clin Immunol. 2000 Jul;96(1):29-37 [10873425] Cytokine. 2000 Jul;12(7):960-71 [10880241] Pharm Res. 2000 Oct;17(10):1159-67 [11145219] Cancer Res. 2001 Jan 1;61(1):206-14 [11196163] Biochim Biophys Acta. 2001 Mar 30;1531(1-2):99-110 [11278176] Pharm Res. 2001 Jul;18(7):899-906 [11496947] J Pharm Pharmacol. 2001 Aug;53(8):1047-67 [11518015] Crit Rev Ther Drug Carrier Syst. 2001;18(6):551-66 [11789675] J Pharm Sci. 2002 May;91(5):1245-51 [11977100] Infect Immun. 2003 Feb;71(2):726-32 [12540551] Eur J Pharm Sci. 2003 Mar;18(3-4):221-9 [12659933] J Control Release. 2003 Sep 4;91(3):299-313 [12932709] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma. AN - 69081164; 18094423 AB - To characterize the pharmacokinetics of temsirolimus and its major metabolite, sirolimus, in patients receiving enzyme-inducing antiepileptic drugs (EIAED) compared with patients receiving non-EIAEDs. An additional objective was to determine whether concentrations of temsirolimus or sirolimus were achieved in brain tumor tissue. Patients with recurrent malignant gliomas not receiving EIAEDs initially received temsirolimus weekly at a dose of 250 mg i.v. The dose was subsequently reduced to 170 mg due to intolerable side effects. For patients taking EIAEDs, the starting dose of temsirolimus was 250 mg with standard dose escalation until the maximal tolerated dose was established. Ten whole blood samples were obtained over a period of 24 h after administration of temsirolimus for pharmacokinetic assessments. Patients eligible for cytoreductive surgery received temsirolimus before tumor resection. Whole blood and tumor tissue were obtained for analysis. Significant differences in the pharmacokinetic variables for temsirolimus and sirolimus were observed between the two patient groups at a comparable dose level of 250 mg. For patients receiving EIAEDs, the systemic exposure to temsirolimus was lower by 1.5-fold. Likewise, peak concentrations and exposure to sirolimus were lower by 2-fold. Measurable concentrations of temsirolimus and sirolimus were observed in brain tumor specimens. The average tissue to whole blood ratio for temsirolimus was 1.43 and 0.84 for sirolimus. Drugs that induce cytochrome P450 3A4, such as EIAEDs, significantly affect the pharmacokinetics of temsirolimus and its active metabolite, sirolimus. Total exposure to temsirolimus and sirolimus was lower in the EIAED group at the maximum tolerated dose of 250 mg compared with the non-EIAED group at the maximum tolerated dose of 170 mg. However, brain tumor tissue concentrations of temsirolimus and sirolimus were relatively comparable in both groups of patients at their respective dose levels. Correlative analyses of the tissue for the inhibition of the key regulators (p70S6 kinase and 4E-binding protein 1) of mammalian target of rapamycin are necessary to define the therapeutic significance of the altered exposure to temsirolimus. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kuhn, John G AU - Chang, Susan M AU - Wen, Patrick Y AU - Cloughesy, Timothy F AU - Greenberg, Harry AU - Schiff, David AU - Conrad, Charles AU - Fink, Karen L AU - Robins, H Ian AU - Mehta, Minesh AU - DeAngelis, Lisa AU - Raizer, Jeffrey AU - Hess, Kenneth AU - Lamborn, Kathleen R AU - Dancey, Janet AU - Prados, Michael D AU - North American Brain Tumor Consortium and the National Cancer Institute AD - Pharmacotherapy Education and Research Center, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Kuhn@uthscsa.edu ; North American Brain Tumor Consortium and the National Cancer Institute Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 7401 EP - 7406 VL - 13 IS - 24 SN - 1078-0432, 1078-0432 KW - Anticonvulsants KW - 0 KW - Antineoplastic Agents KW - temsirolimus KW - 624KN6GM2T KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Drug Interactions KW - Neoplasm Recurrence, Local -- drug therapy KW - Area Under Curve KW - Humans KW - Metabolic Clearance Rate KW - Cytochrome P-450 Enzyme System -- metabolism KW - Maximum Tolerated Dose KW - Cytochrome P-450 Enzyme System -- drug effects KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- surgery KW - Antineoplastic Agents -- pharmacokinetics KW - Sirolimus -- pharmacokinetics KW - Anticonvulsants -- therapeutic use KW - Glioma -- surgery KW - Sirolimus -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69081164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=An+HIV+RNase+H+Inhibitory+1%2C3%2C4%2C5-Tetragalloylapiitol+from+the+African+Plant+Hylodendron+gabunensis&rft.au=Takada%2C+K%3BBermingham%2C+A%3BO%27Keefe%2C+B+R%3BWamiru%2C+A%3BBeutler%2C+JA%3BLe+Grice%2C+SFJ%3BLloyd%2C+J%3BGustafson%2C+K+R%3BMcMahon%2C+J+B&rft.aulast=Takada&rft.aufirst=K&rft.date=2007-10-01&rft.volume=70&rft.issue=10&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp0702279 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence. AN - 69076134; 18089797 AB - Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function. In contrast to mice carrying two distinct POT1 genes encoding two POT1 proteins (POT1a and POT1b), humans have the single POT1 gene. In addition to full-length POT1 protein (variant v1), the human POT1 gene encodes four other variants due to alternative RNA splicing (variants v2, v3, v4, and v5), whose functions are poorly understood. The functional analyses of the NH(2)-terminally and COOH-terminally truncated POT1 variants in this study showed that neither the single-stranded telomere-binding ability of the NH(2)-terminal oligonucleotide-binding (OB) folds nor the telomerase-dependent telomere elongation activity mediated by the COOH-terminal TPP1-interacting domain was telomere protective by itself. Importantly, a COOH-terminally truncated variant (v5), which consists of the NH(2)-terminal OB folds and the central region of unknown function, was found to protect telomeres and prevent cellular senescence as efficiently as v1. Our data revealed mechanistic and functional differences between v1 and v5: (a) v1, but not v5, functions through the maintenance of telomeric 3' overhangs; (b) p53 is indispensable to v5 knockdown-induced senescence; and (c) v5 functions at only a fraction of telomeres to prevent DNA damage signaling. Furthermore, v5 was preferentially expressed in mismatch repair (MMR)-deficient cells and tumor tissues, suggesting its role in chromosome stability associated with MMR deficiency. This study highlights a human-specific complexity in telomere protection and damage signaling conferred by functionally distinct isoforms from the single POT1 gene. JF - Cancer research AU - Yang, Qin AU - Zhang, Ran AU - Horikawa, Izumi AU - Fujita, Kaori AU - Afshar, Yalda AU - Kokko, Antti AU - Laiho, Päivi AU - Aaltonen, Lauri A AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 11677 EP - 11686 VL - 67 IS - 24 KW - POT1 protein, human KW - 0 KW - RNA, Catalytic KW - Telomere-Binding Proteins KW - hairpin ribozyme KW - Index Medicus KW - RNA, Catalytic -- genetics KW - Alternative Splicing KW - Humans KW - Foreskin -- physiology KW - Telomere-Binding Proteins -- physiology KW - Telomere-Binding Proteins -- genetics KW - Gene Expression Regulation KW - Cell Line, Tumor KW - Foreskin -- cytology KW - Male KW - Cell Line KW - Fibroblasts -- physiology KW - Genetic Variation KW - Telomere -- physiology KW - Cell Aging -- physiology KW - Telomere -- genetics KW - Cell Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Functional+diversity+of+human+protection+of+telomeres+1+isoforms+in+telomere+protection+and+cellular+senescence.&rft.au=Sommer%2C+W+H%3BRimondini%2C+R%3BMarquitz%2C+M%3BLidstr%C3%B6m%2C+J%3BSiems%2C+W-E%3BBader%2C+M%3BHeilig%2C+M&rft.aulast=Sommer&rft.aufirst=W&rft.date=2007-10-01&rft.volume=85&rft.issue=10&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.issn=09462716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma. AN - 69027341; 17846226 AB - Thirty-six patients with AIDS-associated Kaposi sarcoma (KS) requiring chemotherapy were treated for six 3-week cycles of pegylated liposomal doxorubicin (20 mg/m(2)) plus interleukin-12 (IL-12; 300 ng/kg subcutaneously twice weekly), followed by 500 ng/kg subcutaneous IL-12 twice weekly for up to 3 years. All received highly active antiretroviral therapy (HAART). Twenty-two had poor-prognosis KS (T(1)S(1)). Thirty patients had a major response, including 9 with complete response, yielding an 83.3% major response rate (95% confidence interval: 67.2%-93.6%). Median time to first response was 2 cycles. Median progression was not reached at median potential follow-up of 46.9 months. Of 27 patients with residual disease when starting maintenance IL-12, 15 had a new major response compared with this new baseline. The regimen was overall well tolerated; principal toxicities were neutropenia, anemia, transaminitis, and neuropsychiatric toxicity. Patients had increases in serum IL-12, interferon gamma, and inducible protein-10 (IP-10), and these remained increased at weeks 18 and 34. The regimen of IL-12 plus liposomal doxorubicin yielded rapid tumor responses and a high response rate in patients with AIDS-KS receiving HAART, and responses were sustained on IL-12 maintenance therapy. A randomized trial of IL-12 in this setting may be warranted. This study is registered at (http://www.clinicaltrials.gov) as no. NCT00020449. JF - Blood AU - Little, Richard F AU - Aleman, Karen AU - Kumar, Pallavi AU - Wyvill, Kathleen M AU - Pluda, James M AU - Read-Connole, Elizabeth AU - Wang, Victoria AU - Pittaluga, Stefania AU - Catanzaro, Andrew T AU - Steinberg, Seth M AU - Yarchoan, Robert AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1868, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 4165 EP - 4171 VL - 110 IS - 13 SN - 0006-4971, 0006-4971 KW - CXCL10 protein, human KW - 0 KW - Chemokine CXCL10 KW - liposomal doxorubicin KW - Interleukin-12 KW - 187348-17-0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Doxorubicin KW - 80168379AG KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Chemokine CXCL10 -- blood KW - Humans KW - Adult KW - Treatment Outcome KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - Interferon-gamma -- blood KW - Remission Induction KW - Sarcoma, Kaposi -- drug therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Doxorubicin -- analogs & derivatives KW - Interleukin-12 -- administration & dosage KW - Polyethylene Glycols -- toxicity KW - Doxorubicin -- toxicity KW - Doxorubicin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Interleukin-12 -- blood KW - Interleukin-12 -- toxicity KW - Sarcoma, Kaposi -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Phase+2+study+of+pegylated+liposomal+doxorubicin+in+combination+with+interleukin-12+for+AIDS-related+Kaposi+sarcoma.&rft.au=Little%2C+Richard+F%3BAleman%2C+Karen%3BKumar%2C+Pallavi%3BWyvill%2C+Kathleen+M%3BPluda%2C+James+M%3BRead-Connole%2C+Elizabeth%3BWang%2C+Victoria%3BPittaluga%2C+Stefania%3BCatanzaro%2C+Andrew+T%3BSteinberg%2C+Seth+M%3BYarchoan%2C+Robert&rft.aulast=Little&rft.aufirst=Richard&rft.date=2007-12-15&rft.volume=110&rft.issue=13&rft.spage=4165&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00020449; ClinicalTrials.gov N1 - SuppNotes - Cited By: Clin Exp Immunol. 2000 Jan;119(1):28-37 [10606961] J Exp Med. 1998 Jul 20;188(2):405-8 [9670053] Cancer Res. 2000 Sep 1;60(17):4873-80 [10987301] J Infect Dis. 2001 Apr 1;183(7):1116-20 [11237839] AIDS. 2001 Mar 30;15(5):629-33 [11317001] HIV Clin Trials. 2001 Sep-Oct;2(5):429-37 [11673818] J Invest Dermatol. 2001 Oct;117(4):858-63 [11676823] AIDS. 2002 May 24;16(8):1147-54 [12004273] J Natl Cancer Inst. 2002 Aug 21;94(16):1204-10 [12189223] J Infect Dis. 2003 Jan 1;187(1):149-53 [12508160] Clin Cancer Res. 2003 Jan;9(1):76-83 [12538454] AIDS. 2004 Aug 20;18(12):1737-40 [15280789] Technol Cancer Res Treat. 2004 Oct;3(5):451-7 [15453810] N Engl J Med. 1985 Jul 11;313(2):79-84 [2582258] J Biol Response Mod. 1985 Aug;4(4):358-64 [3928825] Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] J Exp Med. 1989 Sep 1;170(3):827-45 [2504877] J Clin Oncol. 1989 Sep;7(9):1201-7 [2671281] Immunol Today. 1991 Oct;12(10):346-8 [1683536] Am J Epidemiol. 1993 Aug 15;138(4):266-78 [8356967] J Exp Med. 1993 Oct 1;178(4):1223-30 [8104230] Blood. 1993 Nov 1;82(9):2790-6 [8106018] Clin Oncol (R Coll Radiol). 1993;5(6):367-71 [8305357] J Acquir Immune Defic Syndr. 1994 May;7(5):463-8 [8158540] Eur J Cancer. 1998 Dec;34(13):2101-6 [10070318] Clin Cancer Res. 1999 Jul;5(7):1905-17 [10430098] J Clin Oncol. 2005 Feb 10;23(5):990-8 [15598977] J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):293-9 [15980688] Int J Oncol. 2005 Sep;27(3):779-85 [16077928] Nat Clin Pract Oncol. 2005 Aug;2(8):406-15; quiz 423 [16130937] Blood. 2006 Jun 15;107(12):4650-7 [16507779] J Clin Oncol. 2003 Aug 1;21(15):2876-82 [12885804] J Clin Oncol. 2004 Feb 1;22(3):399-402 [14752065] N Engl J Med. 2004 Jun 3;350(23):2335-42 [15175435] Cancer. 2004 Jul 15;101(2):317-24 [15241829] J Immunol. 1994 Aug 15;153(4):1697-706 [7913943] Blood. 1994 Dec 15;84(12):4008-27 [7994020] Science. 1994 Dec 16;266(5192):1865-9 [7997879] Blood. 1996 May 1;87(9):3877-82 [8611715] Cancer Chemother Pharmacol. 1996;38(2):169-77 [8616908] J Leukoc Biol. 1996 May;59(5):623-30 [8656046] J Virol. 1996 Nov;70(11):8218-23 [8892957] Blood. 1997 Apr 15;89(8):2635-43 [9108380] J Immunol. 1997 May 15;158(10):4992-5001 [9144519] J Clin Oncol. 1997 Sep;15(9):3085-92 [9294471] Nature. 1998 Jan 1;391(6662):86-9 [9422510] Cancer Chemother Pharmacol. 1998;41(6):497-504 [9554595] AIDS. 2000 May 26;14(8):987-93 [10853980] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. AN - 68545995; 17959361 AB - Subjects at high risk for alcoholism have a greater propensity for externalizing behaviors and brain volume reductions of possible neurodevelopmental origin. Morphometric deficits in the corpus callosum (CC), which might reflect this neurodevelopmental abnormality, have been reported in other externalizing disorders such as attention deficit hyperactivity disorder, but not in subjects at high risk for alcoholism. The objective of the current study was to evaluate the CC morphometry in subjects at high risk for alcoholism. Magnetic resonance images of the CC in high-risk subjects (n=20) were compared with those of low-risk subjects matched to the high-risk subjects for age, sex, and handedness (n=20). Mid-sagittal areas of the CC, genu, body, isthmus and splenium were measured based on Witelson's method with good inter- and intra-rater reliability. Externalizing behaviors were assessed using the Semi-Structured Assessment for Genetics of Alcoholism-II. Total CC, genu and isthmus areas were significantly smaller in high-risk than low-risk subjects after controlling for age and intracranial area. The total externalizing symptoms score had a significant negative correlation with genu and isthmus areas. Smaller CC areas and their negative association with externalizing behaviors may represent yet another marker of susceptibility to alcoholism in high-risk subjects. JF - Psychiatry research AU - Venkatasubramanian, Ganesan AU - Anthony, George AU - Reddy, Umesh Srinivasa AU - Reddy, Varun Venkatesh AU - Jayakumar, Peruvumba N AU - Benegal, Vivek AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. gvs@nimhans.kar.nic.in Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 209 EP - 215 VL - 156 IS - 3 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Image Interpretation, Computer-Assisted KW - Risk Factors KW - Humans KW - Adult KW - Child of Impaired Parents -- statistics & numerical data KW - Child KW - Adolescent KW - Male KW - Agenesis of Corpus Callosum KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68545995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Corpus+callosum+abnormalities+associated+with+greater+externalizing+behaviors+in+subjects+at+high+risk+for+alcohol+dependence.&rft.au=Venkatasubramanian%2C+Ganesan%3BAnthony%2C+George%3BReddy%2C+Umesh+Srinivasa%3BReddy%2C+Varun+Venkatesh%3BJayakumar%2C+Peruvumba+N%3BBenegal%2C+Vivek&rft.aulast=Venkatasubramanian&rft.aufirst=Ganesan&rft.date=2007-12-15&rft.volume=179&rft.issue=7&rft.spage=4367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase. AN - 68541740; 17705785 AB - InsP6 is an intracellular signal with several proposed functions that is synthesized by IP5K [Ins(1,3,4,5,6)P5 2-kinase]. In the present study, we overexpressed EGFP (enhanced green fluorescent protein)-IP5K fusion proteins in NRK (normal rat kidney), COS7 and H1299 cells. The results indicate that there is spatial microheterogeneity in the intracellular localization of IP5K that could also be confirmed for the endogenous enzyme. This may facilitate changes in InsP6 levels at its sites of action. For example, overexpressed IP5K showed a structured organization within the nucleus. The kinase was preferentially localized in euchromatin and nucleoli, and co-localized with mRNA. In the cytoplasm, the overexpressed IP5K showed locally high concentrations in discrete foci. The latter were attributed to stress granules by using mRNA, PABP [poly(A)-binding protein] and TIAR (TIA-1-related protein) as markers. The incidence of stress granules, in which IP5K remained highly concentrated, was further increased by puromycin treatment. Using FRAP (fluorescence recovery after photobleaching) we established that IP5K was actively transported into the nucleus. By site-directed mutagenesis we identified a nuclear import signal and a peptide segment mediating the nuclear export of IP5K. JF - The Biochemical journal AU - Brehm, Maria A AU - Schenk, Tobias M H AU - Zhou, Xuefei AU - Fanick, Werner AU - Lin, Hongying AU - Windhorst, Sabine AU - Nalaskowski, Marcus M AU - Kobras, Mario AU - Shears, Stephen B AU - Mayr, Georg W AD - NIEHS/NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 335 EP - 345 VL - 408 IS - 3 KW - DNA Primers KW - 0 KW - RNA, Messenger KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - inositol 1,3,4,5,6-pentakisphosphate 2-kinase KW - Index Medicus KW - Animals KW - COS Cells KW - Humans KW - In Situ Hybridization, Fluorescence KW - Amino Acid Sequence KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Chromatography, High Pressure Liquid KW - Mutagenesis, Site-Directed KW - Microscopy, Fluorescence KW - Base Sequence KW - Kinetics KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Subcellular Fractions -- enzymology KW - Phosphotransferases (Alcohol Group Acceptor) -- chemistry KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Phosphotransferases (Alcohol Group Acceptor) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68541740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Intracellular+localization+of+human+Ins%281%2C3%2C4%2C5%2C6%29P5+2-kinase.&rft.au=Brehm%2C+Maria+A%3BSchenk%2C+Tobias+M+H%3BZhou%2C+Xuefei%3BFanick%2C+Werner%3BLin%2C+Hongying%3BWindhorst%2C+Sabine%3BNalaskowski%2C+Marcus+M%3BKobras%2C+Mario%3BShears%2C+Stephen+B%3BMayr%2C+Georg+W&rft.aulast=Brehm&rft.aufirst=Maria&rft.date=2007-12-15&rft.volume=408&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-09 N1 - Date created - 2007-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1993 Jan 15;268(2):1032-8 [8419311] Science. 1992 Dec 11;258(5089):1812-5 [1465619] J Chromatogr B Biomed Appl. 1995 Oct 20;672(2):189-98 [8581124] Science. 1996 Oct 25;274(5287):546, 563-7 [8849441] Exp Cell Res. 1997 Oct 10;236(1):346-50 [9344616] Biotechniques. 1999 Apr;26(4):680-2 [10343905] Science. 1999 Jul 2;285(5424):96-100 [10390371] J Biol Chem. 2004 Nov 5;279(45):47222-32 [15322119] Mol Biol Cell. 2004 Dec;15(12):5383-98 [15371533] J Biol Chem. 2004 Dec 3;279(49):51022-32 [15459192] Mol Biol Cell. 2005 Jan;16(1):405-20 [15525674] J Biol Chem. 2005 Jan 14;280(2):1156-64 [15528195] J Biol Chem. 2005 Jan 21;280(3):1911-20 [15531582] J Inorg Biochem. 2005 Mar;99(3):828-40 [15708805] Mol Cell Biol. 2005 Mar;25(6):2463-74 [15743838] J Physiol. 2005 Jul 15;566(Pt 2):295-300 [15860522] J Biol Chem. 2005 Aug 12;280(32):29263-8 [15967797] J Virol. 2005 Sep;79(18):11864-72 [16140763] Science. 2005 Sep 2;309(5740):1534-9 [16141067] Biotechniques. 2005 Dec;39(6):814, 816, 818 passim [16382897] J Biol Chem. 2006 Jan 6;281(1):608-16 [16249182] Cell Mol Life Sci. 2006 Mar;63(5):552-64 [16429326] Biol Chem. 2006 May;387(5):583-93 [16740130] Biochim Biophys Acta. 2006 May-Jun;1761(5-6):552-9 [16781889] Annu Rev Cell Dev Biol. 1999;15:607-60 [10611974] Science. 2000 Mar 17;287(5460):2026-9 [10720331] J Biol Chem. 2000 Aug 11;275(32):24686-92 [10827188] J Biol Chem. 2000 Nov 24;275(47):36575-83 [10960485] J Cell Biol. 2000 Dec 11;151(6):1257-68 [11121440] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2306-11 [11226235] Cell Signal. 2001 Mar;13(3):151-8 [11282453] RNA. 2001 Dec;7(12):1768-80 [11780633] Curr Biol. 2002 Jan 8;12(1):13-25 [11790299] Biochem J. 2002 Sep 1;366(Pt 2):549-56 [12027805] J Biol Chem. 2002 Aug 30;277(35):31857-62 [12084730] Biochem Soc Trans. 2002 Nov;30(Pt 6):963-9 [12440955] Science. 2003 Jan 3;299(5603):114-6 [12434012] Science. 2003 Jan 3;299(5603):112-4 [12434013] Nat Struct Biol. 2003 Feb;10(2):81-3 [12555081] Trends Cell Biol. 2003 Jun;13(6):319-27 [12791298] Biochem J. 2004 Jan 15;377(Pt 2):265-80 [14567754] Curr Mol Med. 2004 May;4(3):277-90 [15101685] Cell Mol Life Sci. 2004 May;61(10):1143-56 [15141300] Biochem Biophys Res Commun. 2004 Jun 11;318(4):1079-84 [15147984] Nucleic Acids Res. 2004;32(9):2776-84 [15150344] Biochem J. 2004 Aug 15;382(Pt 1):353-62 [15130091] J Biol Chem. 2004 Oct 15;279(42):43403-10 [15297462] Leukemia. 2004 Nov;18(11):1839-49 [15457186] Chromosoma. 1976 Nov 29;58(4):307-24 [137107] Biochem J. 1988 Sep 1;254(2):585-91 [3178774] Biochem J. 1991 Apr 15;275 ( Pt 2):485-99 [1850990] J Biol Chem. 1994 Nov 11;269(45):28393-9 [7961779] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of harmful algal bloom outreach activities. AN - 733698625; 18463727 AB - With an apparent increase of harmful algal blooms (HABs) worldwide, healthcare providers, public health personnel and coastal managers are struggling to provide scientifically-based appropriately-targeted HAB outreach and education. Since 1998, the Florida Poison Information Center-Miami, with its 24 hour/365 day/year free Aquatic Toxins Hotline (1-888-232-8635) available in several languages, has received over 25,000 HAB-related calls. As part of HAB surveillance, all possible cases of HAB-related illness among callers are reported to the Florida Health Department. This pilot study evaluated an automated call processing menu system that allows callers to access bilingual HAB information, and to speak directly with a trained Poison Information Specialist. The majority (68%) of callers reported satisfaction with the information, and many provided specific suggestions for improvement. This pilot study, the first known evaluation of use and satisfaction with HAB educational outreach materials, demonstrated that the automated system provided useful HAB-related information for the majority of callers, and decreased the routine informational call workload for the Poison Information Specialists, allowing them to focus on callers needing immediate assistance and their healthcare providers. These results will lead to improvement of this valuable HAB outreach, education and surveillance tool. Formal evaluation is recommended for future HAB outreach and educational materials. JF - Marine drugs AU - Fleming, Lora E AU - Jerez, Eva AU - Stephan, Wendy Blair AU - Cassedy, Amy AU - Bean, Judy A AU - Reich, Andrew AU - Kirkpatrick, Barbara AU - Backer, Lorraine AU - Nierenberg, Kate AU - Watkins, Sharon AU - Hollenbeck, Julie AU - Weisman, Richard AD - NSF NIEHS Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33136 USA. lfleming@med.miami.edu Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 208 EP - 219 VL - 5 IS - 4 KW - cyanobacteria KW - Poison Information Centers KW - paralytic shellfish poisoning (PSP) KW - neurotoxic shellfish poisoning (NSP) KW - Solutions to Avoid Red Tide (START) KW - Harmful algal bloom (HAB) KW - ciguatera fish poisoning KW - blue green algae KW - ciguatoxins KW - human health effects KW - Karenia brevis KW - Florida red tide KW - brevetoxins KW - outreach and education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733698625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Administration+of+a+CD25-directed+immunotoxin%2C+LMB-2%2C+to+patients+with+metastatic+melanoma+induces+a+selective+partial+reduction+in+regulatory+T+cells+in+vivo.&rft.au=Powell%2C+Daniel+J%3BFelipe-Silva%2C+Aloisio%3BMerino%2C+Maria+J%3BAhmadzadeh%2C+Mojgan%3BAllen%2C+Tamika%3BLevy%2C+Catherine%3BWhite%2C+Donald+E%3BMavroukakis%2C+Sharon%3BKreitman%2C+Robert+J%3BRosenberg%2C+Steven+A%3BPastan%2C+Ira&rft.aulast=Powell&rft.aufirst=Daniel&rft.date=2007-10-01&rft.volume=179&rft.issue=7&rft.spage=4919&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-17 N1 - Date created - 2008-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mar Pollut Bull. 2006;53(10-12):545-60 [16996542] Chest. 2007 Jan;131(1):187-94 [17218574] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae. AN - 69050588; 17928288 AB - The D7-related (D7r) proteins of the malaria vector Anopheles gambiae have been shown to bind the biogenic amines serotonin, norepinephrine, and histamine with high affinity. One member of the group (D7r1 or hamadarin) has also been shown to have an anticoagulant/antikinin activity. To understand the mechanistic details of its antihemostatic/anti-inflammatory effects, we have determined the crystal structure of one member of this group, D7r4, along with the structures of ligand complexes with serotonin, tryptamine, histamine, and norepinephrine. The D7 fold consists of an arrangement of eight alpha-helices stabilized by three disulfide bonds. The structure is similar to those of the arthropod odorant-binding proteins, a relationship that had been predicted based on sequence comparisons. Although odorant-binding proteins commonly have six alpha-helices, D7r4 has eight, resulting in significantly different positioning and structure of the ligand binding pocket. The pocket itself is lined by hydrophobic side chains along with polar and charged groups oriented to form hydrogen bonds with the aliphatic amino group and with groups on the aromatic portions of the ligands. These structures, along with accompanying mutagenesis studies, have allowed us to identify critical residues for biogenic amine binding and to predict which members of the large D7 protein family found in blood-feeding nematocerous Diptera will function as biogenic amine-binding proteins. JF - The Journal of biological chemistry AU - Mans, Ben J AU - Calvo, Eric AU - Ribeiro, José M C AU - Andersen, John F AD - Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 36626 EP - 36633 VL - 282 IS - 50 SN - 0021-9258, 0021-9258 KW - Biogenic Amines KW - 0 KW - Disulfides KW - Insect Proteins KW - Salivary Proteins and Peptides KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Arthropod Vectors -- metabolism KW - Animals KW - Protein Structure, Secondary KW - Disulfides -- chemistry KW - Malaria -- transmission KW - Arthropod Vectors -- chemistry KW - Crystallography, X-Ray KW - Hydrogen Bonding KW - Disulfides -- metabolism KW - Binding Sites -- physiology KW - Structure-Activity Relationship KW - Salivary Proteins and Peptides -- chemistry KW - Biogenic Amines -- metabolism KW - Biogenic Amines -- chemistry KW - Salivary Proteins and Peptides -- metabolism KW - Insect Proteins -- chemistry KW - Anopheles gambiae -- chemistry KW - Insect Proteins -- metabolism KW - Anopheles gambiae -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69050588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+crystal+structure+of+D7r4%2C+a+salivary+biogenic+amine-binding+protein+from+the+malaria+mosquito+Anopheles+gambiae.&rft.au=Mans%2C+Ben+J%3BCalvo%2C+Eric%3BRibeiro%2C+Jos%C3%A9+M+C%3BAndersen%2C+John+F&rft.aulast=Mans&rft.aufirst=Ben&rft.date=2007-12-14&rft.volume=282&rft.issue=50&rft.spage=36626&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2QEO; PDB; 2QEB; 2QEV; 2QEH; 2PQL N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions. AN - 69047652; 17911100 AB - Metal-catalyzed oxidation reactions target amino acids in the metal binding pocket of proteins. Such oxidation reactions generally result in either preferential degradation of the protein or accumulation of a catalytically inactive pool of protein with age. Consistently, levels of oxidized proteins have been shown to increase with age. The segmental, progeroid disorder Werner syndrome results from loss of the Werner syndrome protein (WRN). WRN is a member of the RecQ family of DNA helicases and possesses exonuclease and ATP-dependent helicase activities. Furthermore, each of the helicase and exonuclease domains of WRN contains a metal binding pocket. In this report we examined for metal-catalyzed oxidation of WRN in the presence of iron or copper. We found that WRN was oxidized in vitro by iron but not by copper. Iron-mediated oxidation resulted in the inhibition of both WRN helicase and exonuclease activities. Oxidation of WRN also inhibited binding to several known protein partners. In addition, we did not observe degradation of oxidized WRN by the 20 S proteasome in vitro. Finally, exposure of cells to hydrogen peroxide resulted in oxidation of WRN in vivo. Therefore, our results demonstrate that WRN undergoes metal-catalyzed oxidation in the presence of iron, and iron-mediated oxidation of WRN likely results in the accumulation of a catalytically inactive form of the protein, which may contribute to age-related phenotypes. JF - The Journal of biological chemistry AU - Harrigan, Jeanine A AU - Piotrowski, Jason AU - Di Noto, Luca AU - Levine, Rodney L AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 36403 EP - 36411 VL - 282 IS - 50 SN - 0021-9258, 0021-9258 KW - Oxidants KW - 0 KW - Recombinant Proteins KW - Copper KW - 789U1901C5 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Index Medicus KW - Oxidants -- pharmacology KW - Oxidation-Reduction -- drug effects KW - HeLa Cells KW - Humans KW - Copper -- metabolism KW - Hydrogen Peroxide -- pharmacology KW - Binding Sites -- physiology KW - Copper -- chemistry KW - Phenotype KW - Proteasome Endopeptidase Complex -- metabolism KW - Recombinant Proteins -- metabolism KW - Protein Structure, Tertiary -- physiology KW - Recombinant Proteins -- chemistry KW - Catalysis KW - Werner Syndrome -- enzymology KW - RecQ Helicases -- metabolism KW - Iron -- chemistry KW - RecQ Helicases -- chemistry KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Metal-catalyzed+oxidation+of+the+Werner+syndrome+protein+causes+loss+of+catalytic+activities+and+impaired+protein-protein+interactions.&rft.au=Harrigan%2C+Jeanine+A%3BPiotrowski%2C+Jason%3BDi+Noto%2C+Luca%3BLevine%2C+Rodney+L%3BBohr%2C+Vilhelm+A&rft.aulast=Harrigan&rft.aufirst=Jeanine&rft.date=2007-12-14&rft.volume=282&rft.issue=50&rft.spage=36403&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. AN - 69056043; 18074021 AB - DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication. Five human DNA helicases sharing sequence similarity with the E. coli RecQ helicase have been identified. Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer. RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known. In this study, we report that RECQ1 becomes phosphorylated upon DNA damage and forms irradiation-induced nuclear foci that associate with chromatin in human cells. Depletion of RECQ1 renders human cells sensitive to DNA damage induced by ionizing radiation or the topoisomerase inhibitor camptothecin, and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks. Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity. Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis. JF - PloS one AU - Sharma, Sudha AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Y1 - 2007/12/12/ PY - 2007 DA - 2007 Dec 12 SP - 1 VL - 2 IS - 12 KW - Mutagens KW - 0 KW - RNA, Small Interfering KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Base Sequence KW - HeLa Cells KW - Humans KW - Sister Chromatid Exchange KW - DNA Damage KW - RecQ Helicases -- metabolism KW - Oxidative Stress KW - RecQ Helicases -- genetics KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Human+RECQ1+is+a+DNA+damage+responsive+protein+required+for+genotoxic+stress+resistance+and+suppression+of+sister+chromatid+exchanges.&rft.au=Sharma%2C+Sudha%3BBrosh%2C+Robert+M&rft.aulast=Sharma&rft.aufirst=Sudha&rft.date=2007-12-12&rft.volume=2&rft.issue=12&rft.spage=e1297&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nucleic Acids Res. 2004;32(7):2158-70 [15096578] Mol Cell Biol. 2001 Jan;21(1):281-8 [11113202] J Cell Biol. 2001 Apr 16;153(2):367-80 [11309417] J Biol Chem. 2001 Jun 1;276(22):19375-81 [11278509] Mutat Res. 2002 Nov 30;509(1-2):49-78 [12427531] Mol Biol Cell. 2002 Nov;13(11):4100-9 [12429849] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] J Biol Chem. 2003 Jan 17;278(3):1424-32 [12419808] Curr Genet. 2003 Jan;42(4):220-7 [12589473] Science. 1999 Dec 17;286(5448):2342-4 [10600745] Carcinogenesis. 2000 Mar;21(3):485-95 [10688869] Cancer Res. 2000 Mar 1;60(5):1162-7 [10728666] Hum Mol Genet. 2000 Jul 22;9(12):1805-11 [10915769] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Mol Cell Biol. 2003 May;23(10):3692-705 [12724426] Nature. 2003 May 15;423(6937):305-9 [12748644] Nature. 2003 May 15;423(6937):309-12 [12748645] Genes Dev. 2003 Aug 15;17(16):2021-35 [12893777] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972] Curr Genet. 2004 Feb;45(1):37-44 [14595518] Cancer Res. 2004 Mar 1;64(5):1834-42 [14996747] J Cell Biol. 2004 Sep 13;166(6):801-13 [15364958] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Cancer Genet Cytogenet. 1993 Oct 15;70(2):85-93 [8242603] J Biol Chem. 1994 Nov 25;269(47):29838-45 [7961977] Nucleic Acids Res. 1994 Nov 11;22(22):4566-73 [7527136] Genomics. 1995 Apr 10;26(3):595-8 [7607686] Cell. 1997 Feb 7;88(3):323-31 [9039259] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6887-92 [9618508] Exp Cell Res. 1998 Aug 1;242(2):487-94 [9683536] Nature. 2005 Jan 6;433(7021):77-83 [15635413] Blood. 2005 Feb 1;105(3):1003-9 [15454491] Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55 [15688066] Genetics. 2005 Feb;169(2):563-74 [15489516] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Cancer Cell. 2005 Jun;7(6):505-12 [15950900] EMBO J. 2005 Jul 20;24(14):2679-87 [15990871] J Biol Chem. 2005 Jul 29;280(30):28085-94 [15886194] J Biol Chem. 2005 Jul 29;280(30):28072-84 [15899892] J Cell Sci. 2005 Sep 15;118(Pt 18):4261-9 [16141230] Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871] Nucleic Acids Res. 2005;33(19):6251-7 [16260474] Genetics. 2006 Jan;172(1):113-25 [16219790] Cancer Res. 2006 Mar 15;66(6):3323-30 [16540687] J Clin Oncol. 2006 Apr 10;24(11):1720-8 [16520463] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5875-80 [16595622] Science. 2006 Jul 21;313(5785):363-7 [16778019] Biochem J. 2006 Sep 15;398(3):319-37 [16925525] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Mol Cell Biol. 2007 Mar;27(5):1784-94 [17158923] PLoS Biol. 2007 Feb;5(2):e20 [17227144] J Cell Sci. 2007 Mar 1;120(Pt 5):713-21 [17314245] Bioessays. 2007 Apr;29(4):382-5 [17373697] Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497] Oncogene. 2000 Sep 28;19(41):4764-72 [11032027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys. AN - 68423024; 17707792 AB - As kappa agonists have been proposed as treatments for cocaine abuse, the cardiovascular effects of the kappa opioid receptor agonists ethylketocyclazocine (EKC) and enadoline were investigated in conscious squirrel monkeys. Both EKC and enadoline increased heart rate with little effect on blood pressure. This effect appeared to be specific for kappa receptors as the mu opioid agonist morphine did not mimic the effects of the kappa agonists. The opioid antagonist naltrexone, at a dose of 1.0 mg/kg, blocked the effect of EKC. An action at both central and peripheral receptors may be responsible for the heart rate increase following kappa agonist treatment. The ganglionic blocker chlorisondamine partially antagonized the effect of EKC on heart rate, suggesting central involvement, while the peripherally-acting agonist ICI 204,448 ((+/-)-1-[2,3- (Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride) also increased heart rate, supporting a peripheral site of action. When given in combination with cocaine, EKC produced effects that were sub-additive, suggesting that the kappa agonists may be used safely as cocaine abuse treatments. JF - European journal of pharmacology AU - Schindler, Charles W AU - Graczyk, Zofi AU - Gilman, Joanne P AU - Negus, S Stevens AU - Bergman, Jack AU - Mello, Nancy K AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore MD (CWS, ZG, JPG, SRG), United States. cschindl@helix.nih.gov Y1 - 2007/12/08/ PY - 2007 DA - 2007 Dec 08 SP - 107 EP - 113 VL - 576 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Benzofurans KW - 0 KW - Pyrrolidines KW - Receptors, Opioid, kappa KW - Ethylketocyclazocine KW - 58640-84-9 KW - Cocaine KW - I5Y540LHVR KW - enadoline KW - KJL283326C KW - Index Medicus KW - Saimiri KW - Animals KW - Drug Interactions KW - Cocaine-Related Disorders -- drug therapy KW - Cocaine-Related Disorders -- physiopathology KW - Blood Pressure -- drug effects KW - Male KW - Heart Rate -- drug effects KW - Ethylketocyclazocine -- pharmacology KW - Receptors, Opioid, kappa -- agonists KW - Pyrrolidines -- pharmacology KW - Receptors, Opioid, kappa -- physiology KW - Cocaine -- pharmacology KW - Benzofurans -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68423024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Effects+of+kappa+opioid+agonists+alone+and+in+combination+with+cocaine+on+heart+rate+and+blood+pressure+in+conscious+squirrel+monkeys.&rft.au=Schindler%2C+Charles+W%3BGraczyk%2C+Zofi%3BGilman%2C+Joanne+P%3BNegus%2C+S+Stevens%3BBergman%2C+Jack%3BMello%2C+Nancy+K%3BGoldberg%2C+Steven+R&rft.aulast=Schindler&rft.aufirst=Charles&rft.date=2007-12-08&rft.volume=576&rft.issue=1-3&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2007-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1991 Nov 22;565(1):67-77 [1685349] Life Sci. 1993;52(7):599-611 [8381501] Pharmacol Res. 1993 Apr;27(3):233-9 [8100996] Br J Pharmacol. 1994 Mar;111(3):843-51 [8019761] J Pharmacol Exp Ther. 1996 Jul;278(1):232-42 [8764356] Biol Signals. 1995 May-Jun;4(3):174-8 [8750944] Neurochem Res. 1996 Nov;21(11):1369-73 [8947927] Can J Physiol Pharmacol. 1998 Mar;76(3):252-8 [9673788] J Exp Anal Behav. 1963 Apr;6:297-8 [13952017] Neuropsychopharmacology. 2005 Mar;30(3):618-32 [15602503] Neuropeptides. 1983 Jan;3(3):193-212 [16229162] Br J Pharmacol. 2006 Jul;148(6):795-806 [16751796] Ann N Y Acad Sci. 2000;909:104-32 [10911926] J Pharmacol Exp Ther. 2001 Apr;297(1):215-23 [11259547] Mol Pharmacol. 2002 Jan;61(1):73-84 [11752208] Am J Cardiol. 2002 Oct 1;90(7):810-1 [12356410] Neuropsychopharmacology. 2003 Jun;28(6):1125-39 [12637953] Eur J Pharmacol. 2004 Feb 6;485(1-3):119-25 [14757131] Br J Pharmacol. 2004 Apr;141(8):1331-4 [15051626] Am J Physiol. 1969 Jul;217(1):24-9 [4977636] Neuropharmacology. 1982 Sep;21(9):923-8 [6128693] Pharmacol Biochem Behav. 1983 Oct;19(4):711-3 [6359177] Peptides. 1983 Sep-Oct;4(5):621-5 [6318199] Eur J Pharmacol. 1983 Dec 9;96(1-2):165-9 [6319158] Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):577-84 [6686694] Pharmacol Rev. 1983 Dec;35(4):283-323 [6144112] Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):20-3 [6096725] Biochem Biophys Res Commun. 1985 Feb 28;127(1):120-8 [3977917] Eur J Pharmacol. 1985 May 8;111(2):263-6 [2410282] Can J Physiol Pharmacol. 1986 Jun;64(6):729-36 [3756625] J Cardiovasc Pharmacol. 1986 Sep-Oct;8(5):950-6 [2429096] Jpn J Pharmacol. 1987 Sep;45(1):125-8 [2890782] Trends Neurosci. 1988 Jul;11(7):308-14 [2465635] Pharmacol Biochem Behav. 1989 Oct;34(2):405-11 [2695944] Br J Pharmacol. 1990 Sep;101(1):183-9 [2178014] J Mol Cell Cardiol. 1990 Oct;22(10):1167-75 [1965662] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. AN - 69047921; 18060055 AB - Government agencies have defined a need to reduce, refine or replace current mammalian-based bioassays with testing methods that use alternative species. Invertebrate species, such as Caenorhabditis elegans, provide an attractive option because of their short life cycles, inexpensive maintenance, and high degree of evolutionary conservation with higher eukaryotes. The C. elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative. Here a high-throughput assay is described that uses flow cytometry to measure C. elegans feeding by determining the size and intestinal fluorescence of hundreds of nematodes after exposure to fluorescent-labeled microspheres. This assay was validated by quantifying fluorescence in feeding-defective C. elegans (eat mutants), and by exposing wild-type nematodes to the neuroactive compounds, serotonin and arecoline. The eat mutations previously determined to cause slow pumping rates exhibited the lowest feeding levels with our assay. Concentration-dependent increases in feeding levels after serotonin exposures were dependent on food availability, while feeding levels decreased in arecoline-exposed nematodes regardless of the presence of food. The effects of the environmental contaminants, cadmium chloride and chlorpyrifos, on wild-type C. elegans feeding were then used to demonstrate an application of the feeding assay. Cadmium exposures above 200 microM led to a sharp drop in feeding levels. Feeding of chlorpyrifos-exposed nematodes decreased in a concentration-dependent fashion with an EC(50) of 2 microM. The C. elegans fluorescence microsphere feeding assay is a rapid, reliable method for the assessment of neurotoxic effects of pharmaceutical drugs, industrial chemicals or environmental agents. This assay may also be applicable to large scale genetic or RNAi screens used to identify genes that are necessary for the development or function of the pharynx or other neuromuscular systems. JF - PloS one AU - Boyd, Windy A AU - McBride, Sandra J AU - Freedman, Jonathan H AD - Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 SP - 1 VL - 2 IS - 12 KW - Index Medicus KW - Animals KW - Drug Evaluation, Preclinical KW - Caenorhabditis elegans -- drug effects KW - Caenorhabditis elegans -- physiology KW - Mutation KW - Feeding Behavior -- drug effects KW - Caenorhabditis elegans -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Effects+of+genetic+mutations+and+chemical+exposures+on+Caenorhabditis+elegans+feeding%3A+evaluation+of+a+novel%2C+high-throughput+screening+assay.&rft.au=Boyd%2C+Windy+A%3BMcBride%2C+Sandra+J%3BFreedman%2C+Jonathan+H&rft.aulast=Boyd&rft.aufirst=Windy&rft.date=2007-12-05&rft.volume=2&rft.issue=12&rft.spage=e1259&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Biotechnol. 2001 Feb;19(2):153-6 [11175730] J Inorg Biochem. 2000 Apr;79(1-4):241-4 [10830873] Environ Toxicol Chem. 2001 Apr;20(4):833-8 [11345460] Int Rev Cytol. 2001;209:207-39 [11580201] J Exp Biol. 2003 Jan;206(Pt 2):223-31 [12477893] J Exp Biol. 2003 Jul;206(Pt 14):2441-57 [12796460] Free Radic Biol Med. 2003 Sep 15;35(6):558-65 [12957648] Environ Toxicol Chem. 2003 Dec;22(12):3049-55 [14713049] Toxicol Appl Pharmacol. 2004 Feb 1;194(3):248-56 [14761681] Nat Immunol. 2004 May;5(5):488-94 [15048112] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8084-9 [15141086] Environ Toxicol Chem. 2004 May;23(5):1235-40 [15180374] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11773-8 [15280551] Genetics. 1974 May;77(1):71-94 [4366476] Can J Zool. 1975 Jul;53(7):894-903 [1079747] Toxicol Appl Pharmacol. 1977 Sep;41(3):667-80 [918994] Science. 1982 May 28;216(4549):1012-4 [6805073] Toxicol Appl Pharmacol. 1982 May;63(3):330-7 [7101297] Mech Ageing Dev. 1983 Jul-Aug;22(3-4):279-86 [6632998] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] J Exp Zool. 1990 Mar;253(3):263-70 [2181052] Genetics. 1993 Apr;133(4):897-917 [8462849] Genetics. 1993 Jun;134(2):455-64 [8325482] Neuron. 1994 Mar;12(3):483-95 [8155316] J Neurosci. 1995 Dec;15(12):8408-18 [8613772] Rev Environ Contam Toxicol. 1995;144:1-93 [8599033] Genetics. 1995 Dec;141(4):1365-82 [8601480] Arch Environ Contam Toxicol. 1997 Jan;32(1):110-4 [9002442] J Exp Zool. 1999 Jul 1;284(2):147-57 [10404644] J Biochem Mol Toxicol. 2005;19(2):87-95 [15849720] Nat Genet. 2005 Aug;37(8):894-8 [16041374] Cell Metab. 2006 Apr;3(4):237-45 [16581001] Dev Biol. 2006 Aug 15;296(2):409-20 [16828468] BMC Dev Biol. 2006;6:39 [16884547] Regul Toxicol Pharmacol. 2006 Oct;46(1):18-22 [16876299] Nat Methods. 2006 Sep;3(9):662-3 [16967553] Methods Mol Biol. 2006;351:275-86 [16988441] Anal Biochem. 2006 Dec 1;359(1):1-17 [16942745] Genetics. 2000 Feb;154(2):635-46 [10655217] Hum Mol Genet. 2000 Apr 12;9(6):869-77 [10767309] Genome Biol. 2001;2(2):REVIEWS1005 [11182891] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus. AN - 68485282; 17727912 AB - Oncolytic adenoviruses as a treatment for cancer have demonstrated limited clinical activity. Contributing to this may be the relevance of preclinical animal models used to study these agents. Syngeneic mouse tumor models are generally non-permissive for adenoviral replication, whereas human tumor xenograft models exhibit attenuated immune responses to the vector. The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for viral replication and exhibits similar inflammatory pathology to humans with adenovirus replicating in the lungs, respiratory passages and cornea. We evaluated three transplantable tumorigenic cotton rat cell lines, CCRT, LCRT and VCRT as models for the study of oncolytic adenoviruses. All three cells lines were readily infected with adenovirus type-5-based vectors and exhibited high levels of transgene expression. The cell lines supported viral replication demonstrated by the induction of cytopathogenic effect (CPE) in tissue culture, increase in virus particle numbers and assembly of virions seen on transmission electron microscopy. In vivo, LCRT and VCRT tumors demonstrated delayed growth after injection with replicating adenovirus. No in vivo antitumor activity was seen in CCRT tumors despite in vitro oncolysis. Adenovirus was also rapidly cleared from the CCRT tumors compared to LCRT and VCRT tumors. The effect observed with the different cotton rat tumor cell lines mimics the variable results of human clinical trials highlighting the potential relevance of this model for assessing the activity and toxicity of oncolytic adenoviruses. JF - Virology AU - Steel, Jason C AU - Morrison, Brian J AU - Mannan, Poonam AU - Abu-Asab, Mones S AU - Wildner, Oliver AU - Miles, Brian K AU - Yim, Kevin C AU - Ramanan, Vijay AU - Prince, Gregory A AU - Morris, John C AD - Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland, USA. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 SP - 131 EP - 142 VL - 369 IS - 1 SN - 0042-6822, 0042-6822 KW - Index Medicus KW - Rats KW - Virion -- ultrastructure KW - Microscopy, Electron, Transmission KW - Animals KW - Viral Plaque Assay KW - Transplantation, Isogeneic KW - Cytopathogenic Effect, Viral KW - Cell Line, Tumor KW - Sigmodontinae KW - Oncolytic Virotherapy -- methods KW - Neoplasms -- virology KW - Adenoviridae -- growth & development KW - Disease Models, Animal KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68485282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Immunocompetent+syngeneic+cotton+rat+tumor+models+for+the+assessment+of+replication-competent+oncolytic+adenovirus.&rft.au=Steel%2C+Jason+C%3BMorrison%2C+Brian+J%3BMannan%2C+Poonam%3BAbu-Asab%2C+Mones+S%3BWildner%2C+Oliver%3BMiles%2C+Brian+K%3BYim%2C+Kevin+C%3BRamanan%2C+Vijay%3BPrince%2C+Gregory+A%3BMorris%2C+John+C&rft.aulast=Steel&rft.aufirst=Jason&rft.date=2007-12-05&rft.volume=47&rft.issue=10&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-21 N1 - Date created - 2007-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Gene Ther. 2001 Jan 1;12(1):25-34 [11177539] J Virol. 2006 Apr;80(7):3549-58 [16537623] Mol Ther. 2001 May;3(5 Pt 1):697-707 [11356075] Hum Gene Ther. 2001 Aug 10;12(12):1591-3 [11529247] Cancer Res. 2001 Oct 15;61(20):7464-72 [11606381] Expert Opin Biol Ther. 2001 May;1(3):525-38 [11727523] Hum Gene Ther. 2002 Jan 1;13(1):101-12 [11779414] Cancer Gene Ther. 2002 Mar;9(3):254-9 [11896441] Cancer Res. 2002 Sep 1;62(17):4968-76 [12208748] Lab Anim. 2002 Oct;36(4):357-72 [12396279] Mol Ther. 2003 Sep;8(3):412-24 [12946314] Mol Ther. 2006 Jul;14(1):107-17 [16690359] Mol Ther. 2007 May;15(5):1016-23 [17375076] Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S157-60 [14508094] Hum Gene Ther. 2003 Dec 10;14(18):1715-26 [14670123] J Natl Cancer Inst. 1968 Feb;40(2):389-405 [5638610] J Infect Dis. 1984 Jul;150(1):92-7 [6086773] Clin Exp Metastasis. 1983 Oct-Dec;1(4):373-80 [6546207] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6191-5 [2166948] Arch Ophthalmol. 1992 Aug;110(8):1167-70 [1323254] J Virol. 1993 Jan;67(1):101-11 [8380066] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4407-11 [8183921] Mol Biotechnol. 1995 Jun;3(3):207-20 [7552690] Science. 1996 Oct 18;274(5286):373-6 [8832876] Science. 1997 Feb 28;275(5304):1320-3 [9036860] Gene Ther. 1997 Apr;4(4):275-9 [9176511] Hum Gene Ther. 1998 Feb 10;9(3):367-78 [9508054] Cancer Gene Ther. 1998 Nov-Dec;5(6):365-70 [9917091] J Immunol. 1999 Jul 1;163(1):184-93 [10384115] Proc Soc Exp Biol Med. 1953 Dec;84(3):570-3 [13134217] Cancer Res. 2004 Nov 1;64(21):8022-8 [15520211] Cancer. 1956 Nov-Dec;9(6):1211-8 [13383455] J Lab Clin Med. 1956 Apr;47(4):573-82 [13307092] J Virol. 2005 Jan;79(2):1308-11 [15613357] Hum Gene Ther. 2005 Jan;16(1):139-46 [15703497] Cancer Res. 2006 Feb 1;66(3):1270-6 [16452178] J Clin Oncol. 2001 Jan 15;19(2):289-98 [11208818] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Family History of Lung Cancer and Lung Cancer Risk among Finnish Male Smokers. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40818217; 4802126 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Kosti, O AU - Gaudet, M M AU - Jiyoung, A AU - Graubard, B I AU - Weinstein, S J AU - Ashby, J AU - Virtamo, J AU - Bergen, A W AU - Albanes, D Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Lung cancer KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40818217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Family+History+of+Lung+Cancer+and+Lung+Cancer+Risk+among+Finnish+Male+Smokers.&rft.au=Kosti%2C+O%3BGaudet%2C+M+M%3BJiyoung%2C+A%3BGraubard%2C+B+I%3BWeinstein%2C+S+J%3BAshby%2C+J%3BVirtamo%2C+J%3BBergen%2C+A+W%3BAlbanes%2C+D&rft.aulast=Kosti&rft.aufirst=O&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Physical Activity on Biomarkers for the Prevention of Breast Cancer: A Twelve-Week Intervention. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817804; 4802118 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Micheli, A AU - Korde, L AU - Venzon, D AU - Eng-Wong, J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Bioindicators KW - Physical activity KW - Prevention KW - Intervention KW - Breast cancer KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Effects+of+Physical+Activity+on+Biomarkers+for+the+Prevention+of+Breast+Cancer%3A+A+Twelve-Week+Intervention.&rft.au=Micheli%2C+A%3BKorde%2C+L%3BVenzon%2C+D%3BEng-Wong%2C+J&rft.aulast=Micheli&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictors of Non-Compliance with Baseline Sigmoidoscopy in the PLCO Screening Trial. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817695; 4801955 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Doria-Rose, V P AU - Schoen, R E AU - Weissfeld, J L AU - Pinsky, P F AU - Hayes, R B AU - Riley, T AU - Laiyemo, A AU - Black, A AU - Marcus, P M Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Sigmoidoscopy KW - Phospholipase C KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Predictors+of+Non-Compliance+with+Baseline+Sigmoidoscopy+in+the+PLCO+Screening+Trial.&rft.au=Doria-Rose%2C+V+P%3BSchoen%2C+R+E%3BWeissfeld%2C+J+L%3BPinsky%2C+P+F%3BHayes%2C+R+B%3BRiley%2C+T%3BLaiyemo%2C+A%3BBlack%2C+A%3BMarcus%2C+P+M&rft.aulast=Doria-Rose&rft.aufirst=V&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapamycin Prevents Tobacco-carcinogen Induced Lung Tumorigenesis and Selectively Reduces Lung-associated Foxp3 Positive Cells. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817672; 4802060 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Granville, C A AU - Mariotti, J AU - Kawabata, S AU - Foley, J AU - Hollander, M Christine AU - Han, W AU - Balogh, A AU - Memmott, R AU - LoPiccolo, J AU - Liewehr, D AU - Steinberg, S AU - Fowler, D H AU - Dennis, P A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Lung KW - Rapamycin KW - Tumorigenesis KW - Foxp3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Effectiveness+of+methylphenidate+in+the+10-month+continuation+phase+of+the+Preschoolers+with+Attention-Deficit%2FHyperactivity+Disorder+Treatment+Study+%28PATS%29.&rft.au=Vitiello%2C+Benedetto%3BAbikoff%2C+Howard+B%3BChuang%2C+Shirley+Z%3BKollins%2C+Scott+H%3BMcCracken%2C+James+T%3BRiddle%2C+Mark+A%3BSwanson%2C+James+M%3BWigal%2C+Tim%3BMcGough%2C+James+J%3BGhuman%2C+Jaswinder+K%3BWigal%2C+Sharon+B%3BSkrobala%2C+Anne+M%3BDavies%2C+Mark%3BPosner%2C+Kelly%3BCunningham%2C+Charles%3BGreenhill%2C+Laurence+L&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-10-01&rft.volume=17&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Index-based Dietary Patterns and Risk of Colorectal Cancer: The NIH-AARP Diet and Health Study. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40816321; 4802097 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Reedy, J AU - Mitrou, P AU - Krebs-Smith, S M AU - Wirfalt, E AU - Flood, A AU - Kipnis, V AU - Leitzmann, M AU - Mouw, T AU - Hollenbeck, A AU - Schatzkin, A AU - Subar, A F Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40816321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Index-based+Dietary+Patterns+and+Risk+of+Colorectal+Cancer%3A+The+NIH-AARP+Diet+and+Health+Study.&rft.au=Reedy%2C+J%3BMitrou%2C+P%3BKrebs-Smith%2C+S+M%3BWirfalt%2C+E%3BFlood%2C+A%3BKipnis%2C+V%3BLeitzmann%2C+M%3BMouw%2C+T%3BHollenbeck%2C+A%3BSchatzkin%2C+A%3BSubar%2C+A+F&rft.aulast=Reedy&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association between Variant Alleles of GSTM1 and GSTT1 and Lung Cancer Risk: A Nested Case-control Study in Washington County, Maryland. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40816201; 4802065 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Lam, T K AU - Ruczinski, I AU - Helzlsouer, K AU - Shugart, Y AU - Li, K E AU - Hoffman, S C AU - Alberg, A J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - USA, Rhode Island, Washington Cty. KW - USA, Maryland KW - Lung cancer KW - GSTM1 protein KW - GSTT1 protein KW - Allelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40816201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=The+Association+between+Variant+Alleles+of+GSTM1+and+GSTT1+and+Lung+Cancer+Risk%3A+A+Nested+Case-control+Study+in+Washington+County%2C+Maryland.&rft.au=Lam%2C+T+K%3BRuczinski%2C+I%3BHelzlsouer%2C+K%3BShugart%2C+Y%3BLi%2C+K+E%3BHoffman%2C+S+C%3BAlberg%2C+A+J&rft.aulast=Lam&rft.aufirst=T&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial Variation in Steroid Hormone and Growth Factor Concentration: US African-American and White Female Newborns. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815836; 4801944 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Agurs-Collins, T D AU - Rohrmann, S AU - Sutcliffe, C G AU - Bienstock, J L AU - Bradwin, G AU - Rifai, N AU - Pollak, M N AU - Platz, E A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Africa KW - Growth factors KW - Steroid hormones KW - Neonates KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Racial+Variation+in+Steroid+Hormone+and+Growth+Factor+Concentration%3A+US+African-American+and+White+Female+Newborns.&rft.au=Agurs-Collins%2C+T+D%3BRohrmann%2C+S%3BSutcliffe%2C+C+G%3BBienstock%2C+J+L%3BBradwin%2C+G%3BRifai%2C+N%3BPollak%2C+M+N%3BPlatz%2C+E+A&rft.aulast=Agurs-Collins&rft.aufirst=T&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preventive Effects of the RXR Agonists Targretin and UAB-30 in Transgenic Mouse Models of Estrogen Receptor (ER) Negative Mammary Cancer. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815329; 4802054 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Lubet, R A AU - Ruppert, J AU - Muccio, D D AU - You, M AU - Brouilette, W J AU - Atigadda, R AU - Steele, V E AU - Juliana, M AU - Grubbs, C J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Estrogen receptors KW - Animal models KW - Retinoid X receptors KW - Transgenic mice KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Preventive+Effects+of+the+RXR+Agonists+Targretin+and+UAB-30+in+Transgenic+Mouse+Models+of+Estrogen+Receptor+%28ER%29+Negative+Mammary+Cancer.&rft.au=Lubet%2C+R+A%3BRuppert%2C+J%3BMuccio%2C+D+D%3BYou%2C+M%3BBrouilette%2C+W+J%3BAtigadda%2C+R%3BSteele%2C+V+E%3BJuliana%2C+M%3BGrubbs%2C+C+J&rft.aulast=Lubet&rft.aufirst=R&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation-associated Genes as Potential Molecular Targets for Dietary Prevention of Colon Carcinogenesis in an AOMDSS Mouse Model. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815291; 4802037 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Bobe, G AU - Lee, G C AU - Mentor-Marcel, R A AU - Kim, Y S AU - Young, M R AU - Colburn, N H Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Prevention KW - Diets KW - Carcinogenesis KW - Colon KW - Animal models KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Inflammation-associated+Genes+as+Potential+Molecular+Targets+for+Dietary+Prevention+of+Colon+Carcinogenesis+in+an+AOMDSS+Mouse+Model.&rft.au=Bobe%2C+G%3BLee%2C+G+C%3BMentor-Marcel%2C+R+A%3BKim%2C+Y+S%3BYoung%2C+M+R%3BColburn%2C+N+H&rft.aulast=Bobe&rft.aufirst=G&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Selective Small Molecule NF-kB Inhibitor from a Highthroughput Cell Based Assay for "AP-1 Hits". T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815283; 4802036 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Kang, M AU - Henrich, C J AU - Bokesch, H R AU - Gustafson, K R AU - Young, M R AU - Colburn, N H Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - NF-B protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=A+Selective+Small+Molecule+NF-kB+Inhibitor+from+a+Highthroughput+Cell+Based+Assay+for+%22AP-1+Hits%22.&rft.au=Kang%2C+M%3BHenrich%2C+C+J%3BBokesch%2C+H+R%3BGustafson%2C+K+R%3BYoung%2C+M+R%3BColburn%2C+N+H&rft.aulast=Kang&rft.aufirst=M&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Translational Targets of Tumor Suppressor PDCD4 through Analysis of Polysomal mRNA Recruitment. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815255; 4801993 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Santhanam, A N AU - Jansen, A P AU - Colburn, N Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Recruitment KW - Translation KW - MRNA KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Identification+of+Translational+Targets+of+Tumor+Suppressor+PDCD4+through+Analysis+of+Polysomal+mRNA+Recruitment.&rft.au=Santhanam%2C+A+N%3BJansen%2C+A+P%3BColburn%2C+N&rft.aulast=Santhanam&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Body Mass Index and Mortality in a Lean Chinese Population. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814653; 4802137 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Zhang, Y AU - Dawsey, S M AU - Taylor, P R AU - Qiao, Y AU - Abnet, C C Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Mortality KW - Body mass KW - Body mass index KW - Population structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Body+Mass+Index+and+Mortality+in+a+Lean+Chinese+Population.&rft.au=Zhang%2C+Y%3BDawsey%2C+S+M%3BTaylor%2C+P+R%3BQiao%2C+Y%3BAbnet%2C+C+C&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-specific Effects of Dietary Carotenoid Intake on Lung Cancer Risk. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814321; 4802111 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Watters, J AU - Mahabir, S AU - Dong, Y AU - Spitz, M AU - Forman, M Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Lung cancer KW - Carotenoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Gender-specific+Effects+of+Dietary+Carotenoid+Intake+on+Lung+Cancer+Risk.&rft.au=Watters%2C+J%3BMahabir%2C+S%3BDong%2C+Y%3BSpitz%2C+M%3BForman%2C+M&rft.aulast=Watters&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retail Tobacco Availability: Measurement Considerations and Relation to Smoking Initiation. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814002; 4801933 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Hunt, Y M AU - Jason, L A AU - Adams, M L AU - Pokorny, S B AU - Schoeny, M E Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Smoking KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Retail+Tobacco+Availability%3A+Measurement+Considerations+and+Relation+to+Smoking+Initiation.&rft.au=Hunt%2C+Y+M%3BJason%2C+L+A%3BAdams%2C+M+L%3BPokorny%2C+S+B%3BSchoeny%2C+M+E&rft.aulast=Hunt&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Inflammation-associated Serum and Colon Markers as Indicators of Nutritional Attenuation of Colon Carcinogenesis in AOM-induced Ob/Ob Mice Consuming Dietary Navy Beans and their Fractions. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40813783; 4801961 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Mentor-Marcel, R A AU - Bobe, G AU - Barrett, K G AU - Young, M R AU - Colburn, N H AU - Albert, P S AU - Bennink, M R AU - Lanza, E Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Mice KW - Carcinogenesis KW - Colon KW - Animal models KW - Beans KW - Navy KW - Nutrition KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40813783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Identification+of+Inflammation-associated+Serum+and+Colon+Markers+as+Indicators+of+Nutritional+Attenuation+of+Colon+Carcinogenesis+in+AOM-induced+Ob%2FOb+Mice+Consuming+Dietary+Navy+Beans+and+their+Fractions.&rft.au=Mentor-Marcel%2C+R+A%3BBobe%2C+G%3BBarrett%2C+K+G%3BYoung%2C+M+R%3BColburn%2C+N+H%3BAlbert%2C+P+S%3BBennink%2C+M+R%3BLanza%2C+E&rft.aulast=Mentor-Marcel&rft.aufirst=R&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishment of a Hereditary Tumor Bank for Molecular Epidemiology Studies. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40813214; 4802129 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Casali-da-Rocha, J AU - Almeida, L AU - Leitao, A AU - Seuanez, H AU - Ferreira, C G Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Tumors KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40813214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Establishment+of+a+Hereditary+Tumor+Bank+for+Molecular+Epidemiology+Studies.&rft.au=Casali-da-Rocha%2C+J%3BAlmeida%2C+L%3BLeitao%2C+A%3BSeuanez%2C+H%3BFerreira%2C+C+G&rft.aulast=Casali-da-Rocha&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Sex Hormones and Risk of Prostate Cancer: A Prospective Study. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40812397; 4801939 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Weiss, J M AU - Huang, W AU - Rinaldi, S AU - Fears, T R AU - Chatterjee, N AU - Hsing, A W AU - Crawford, E David AU - Andriole, G L AU - Kaaks, R AU - Hayes, R B Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Prostate cancer KW - Hormones KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40812397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Endogenous+Sex+Hormones+and+Risk+of+Prostate+Cancer%3A+A+Prospective+Study.&rft.au=Weiss%2C+J+M%3BHuang%2C+W%3BRinaldi%2C+S%3BFears%2C+T+R%3BChatterjee%2C+N%3BHsing%2C+A+W%3BCrawford%2C+E+David%3BAndriole%2C+G+L%3BKaaks%2C+R%3BHayes%2C+R+B&rft.aulast=Weiss&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insulin-like Growth Factors and Risk of Testicular Germ Cell Tumors. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40811687; 4802147 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Chia, V M AU - Quraishi, S AU - Sakoda, L C AU - Graubard, B I AU - Rubertone, M V AU - Chanock, S J AU - Erickson, R L AU - Stanczyk, F Z AU - McGlynn, K A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Growth factors KW - Tumors KW - Germ cells KW - Insulin-like growth factors KW - Testes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40811687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Simultaneous+GC-EI-MS+Determination+of+D9-Tetrahydrocannabinol%2C+11-Hydroxy-D9-Tetrahydrocannabinol%2C+and+11-nor-9-Carboxy-D9-Tetrahydrocannabinol+in+Human+Urine+Following+Tandem+Enzyme-Alkaline+Hydrolysis&rft.au=Abraham%2C+T+T%3BLowe%2C+R+H%3BPirnay%2C+SO%3BDarwin%2C+W+D%3BHuestis%2C+MA&rft.aulast=Abraham&rft.aufirst=T&rft.date=2007-10-01&rft.volume=31&rft.issue=8&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum Levels of Vitamin D Metabolites and Breast Cancer Risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40811329; 4802149 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Freedman, M AU - Chang, S AU - Falk, R T AU - Purdue, M P AU - Huang, W AU - McCarty, C A AU - Hollis, B W AU - Graubard, B I AU - Berg, C D AU - Ziegler, R G Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Breast cancer KW - Ovarian cancer KW - Vitamin D KW - Lung KW - Metabolites KW - Prostate KW - Serum levels KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40811329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Serum+Levels+of+Vitamin+D+Metabolites+and+Breast+Cancer+Risk+in+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+Cancer+Screening+Trial.&rft.au=Freedman%2C+M%3BChang%2C+S%3BFalk%2C+R+T%3BPurdue%2C+M+P%3BHuang%2C+W%3BMcCarty%2C+C+A%3BHollis%2C+B+W%3BGraubard%2C+B+I%3BBerg%2C+C+D%3BZiegler%2C+R+G&rft.aulast=Freedman&rft.aufirst=M&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PAH Exposure and Upper Gastrointestinal Cancers in China. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40810620; 4802169 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Gao, Y AU - Taylor, P Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - China, People's Rep. KW - Cancer KW - Pollution effects KW - Aromatic hydrocarbons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=PAH+Exposure+and+Upper+Gastrointestinal+Cancers+in+China.&rft.au=Gao%2C+Y%3BTaylor%2C+P&rft.aulast=Gao&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Multiple Lifestyle Risk Factors for Cancer in Brazil. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40810577; 4802165 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Mendonca, A L AU - Martins, L F AU - Jardim, B C AU - Almeida, L M AU - Figueiredo, V C AU - Lozana, J A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Brazil KW - Cancer KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Prevalence+of+Multiple+Lifestyle+Risk+Factors+for+Cancer+in+Brazil.&rft.au=Mendonca%2C+A+L%3BMartins%2C+L+F%3BJardim%2C+B+C%3BAlmeida%2C+L+M%3BFigueiredo%2C+V+C%3BLozana%2C+J+A&rft.aulast=Mendonca&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-ethyl-N,N-dipropylthiocarbamate (EPTC) Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study, a Prospective Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40809096; 4802173 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Van Bemmel, D M AU - Visvanathan, K AU - Freeman, L. E. Beane AU - Coble, J B AU - Hoppin, J A AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=S-ethyl-N%2CN-dipropylthiocarbamate+%28EPTC%29+Exposure+and+Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study%2C+a+Prospective+Cohort.&rft.au=Van+Bemmel%2C+D+M%3BVisvanathan%2C+K%3BFreeman%2C+L.+E.+Beane%3BCoble%2C+J+B%3BHoppin%2C+J+A%3BAlavanja%2C+M.+C.R.&rft.aulast=Van+Bemmel&rft.aufirst=D&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancer Incidence among Imazethapyr-exposed Pesticide Applicators in the Agricultural Health Study Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40807725; 4802160 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Koutros, S AU - Hoppin, J A AU - Lynch, C F AU - Christensen, C AU - Lee, W AU - Freeman, L Beane AU - Rusiecki, J AU - Hou, L AU - Ma, X. AU - Zheng, T AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Cancer+Incidence+among+Imazethapyr-exposed+Pesticide+Applicators+in+the+Agricultural+Health+Study+Cohort.&rft.au=Koutros%2C+S%3BHoppin%2C+J+A%3BLynch%2C+C+F%3BChristensen%2C+C%3BLee%2C+W%3BFreeman%2C+L+Beane%3BRusiecki%2C+J%3BHou%2C+L%3BMa%2C+X.%3BZheng%2C+T%3BAlavanja%2C+M.+C.R.&rft.aulast=Koutros&rft.aufirst=S&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Epstein-Barr virus serology and gastric cancer incidence and survival AN - 759320443; 13760000 AB - Among 185 cases of gastric cancer and 200 controls in Linxian, China, Epstein-Barr virus (EBV) seropositivity was not associated with increased risk of gastric cancer. High EBV nuclear antigen titres were associated with longer survival in cardia cancer cases, possibly due to chance.British Journal of Cancer (2007) 97, 1567-1569; doi:10.1038/sj.bjc.6604063 www.bjcancer.com Published online 6 November 2007 JF - British Journal of Cancer AU - Koshiol, J AU - Qiao, Y-L AU - Mark, S D AU - Dawsey, S M AU - Abnet, C C AU - Kamangar, F AU - Lennette, E T AU - Dong, Z-W AU - Taylor, P R AD - [1] 1 Cancer Prevention Fellowship, Division of Cancer Prevention, National Cancer Institute, 6120 Executive Blvd., MSC 7236, Bethesda, MD, USA [2] 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2007/12/03/ PY - 2007 DA - 2007 Dec 03 SP - 1567 EP - 1569 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 97 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Virology & AIDS Abstracts KW - Epstein-Barr virus KW - Survival KW - China, People's Rep. KW - survival KW - Gastric cancer KW - Serology KW - Cancer KW - Internet KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759320443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Altered+chemokine+profile+associated+with+exacerbated+autoimmune+pathology+under+conditions+of+genetic+interferon-gamma+deficiency.&rft.au=Su%2C+Shao+Bo%3BGrajewski%2C+Rafael+S%3BLuger%2C+Dror%3BAgarwal%2C+Rajeev+K%3BSilver%2C+Phyllis+B%3BTang%2C+Jun%3BTuo%2C+Jingsheng%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Su&rft.aufirst=Shao&rft.date=2007-10-01&rft.volume=48&rft.issue=10&rft.spage=4616&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Survival; Gastric cancer; Serology; Internet; survival; Cancer; Epstein-Barr virus; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6604063 ER - TY - JOUR T1 - Gallstones and the risk of biliary tract cancer: a population-based study in China AN - 20516033; 8044893 AB - We conducted a population-based study of 627 patients with biliary tract cancers (368 of gallbladder, 191 bile duct, and 68 ampulla of Vater), 1037 with biliary stones, and 959 healthy controls randomly selected from the Shanghai population, all personally interviewed. Gallstone status was based on information from self-reports, imaging procedures, surgical notes, and medical records. Among controls, a transabdominal ultrasound was performed to detect asymptomatic gallstones. Gallstones removed from cancer cases and gallstone patients were classified by size, weight, colour, pattern, and content of cholesterol, bilirubin, and bile acids. Of the cancer patients, 69% had gallstones compared with 23% of the population controls. Compared with subjects without gallstones, odds ratios associated with gallstones were 23.8 (95% confidence interval (CI), 17.0-33.4), 8.0 (95% CI 5.6-11.4), and 4.2 (95% CI 2.5-7.0) for cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, respectively, persisting when restricted to those with gallstones at least 10 years prior to cancer. Biliary cancer risks were higher among subjects with both gallstones and self-reported cholecystitis, particularly for gallbladder cancer (OR = 34.3, 95% CI 19.9-59.2). Subjects with bile duct cancer were more likely to have pigment stones, and with gallbladder cancer to have cholesterol stones (P < 0.001). Gallstone weight in gallbladder cancer was significantly higher than in gallstone patients (4.9 vs 2.8 grams; P = 0.001). We estimate that in Shanghai 80% (95% CI 75-84%), 59% (56-61%), and 41% (29-59%) of gallbladder, bile duct, and ampulla of Vater cancers, respectively, could be attributed to gallstones. JF - British Journal of Cancer AU - Hsing, A W AU - Gao, Y-T AU - Han, T-Q AU - Rashid, A AU - Sakoda, L C AU - Wang, B-S AU - Shen, M-C AU - Zhang, B-H AU - Niwa, S AU - Chen, J AU - Fraumeni, JF Jr AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd., Bethesda, MD 20852-7234, USA, hsinga@mail.nih.gov Y1 - 2007/12/03/ PY - 2007 DA - 2007 Dec 03 SP - 1577 EP - 1582 VL - 97 IS - 11 SN - 0007-0920, 0007-0920 KW - gallstones KW - Risk Abstracts KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Population dynamics KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20516033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Gallstones+and+the+risk+of+biliary+tract+cancer%3A+a+population-based+study+in+China&rft.au=Hsing%2C+A+W%3BGao%2C+Y-T%3BHan%2C+T-Q%3BRashid%2C+A%3BSakoda%2C+L+C%3BWang%2C+B-S%3BShen%2C+M-C%3BZhang%2C+B-H%3BNiwa%2C+S%3BChen%2C+J%3BFraumeni%2C+JF+Jr&rft.aulast=Hsing&rft.aufirst=A&rft.date=2007-12-03&rft.volume=97&rft.issue=11&rft.spage=1577&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - China, People's Rep., Shanghai; China, People's Rep.; Cancer; cholesterol; Population dynamics DO - http://dx.doi.org/10.1038/sj.bjc.6604047 ER - TY - CPAPER T1 - Secondary Prevention Among Adolescents: Current Knowledge and Intervention Studies Within the Adolescent Trials Network T2 - 2007 National HIV Prevention Conference AN - 39675049; 4737252 JF - 2007 National HIV Prevention Conference AU - Allison, S Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Adolescents KW - Prevention KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39675049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Secondary+Prevention+Among+Adolescents%3A+Current+Knowledge+and+Intervention+Studies+Within+the+Adolescent+Trials+Network&rft.au=Allison%2C+S&rft.aulast=Allison&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Finding What Works in HIV Risk Reduction Interventions with Alcohol Users: Observations Based on a Systematic Review of the Literature, 1996-2007 T2 - 2007 National HIV Prevention Conference AN - 39674423; 4737169 JF - 2007 National HIV Prevention Conference AU - Freeman, R C Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Reviews KW - Risk reduction KW - Alcohols KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Finding+What+Works+in+HIV+Risk+Reduction+Interventions+with+Alcohol+Users%3A+Observations+Based+on+a+Systematic+Review+of+the+Literature%2C+1996-2007&rft.au=Freeman%2C+R+C&rft.aulast=Freeman&rft.aufirst=R&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview Of Biomedical Intervention Research and Methods T2 - 2007 National HIV Prevention Conference AN - 39662375; 4737035 JF - 2007 National HIV Prevention Conference AU - Dieffenbach, C W Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Intervention KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Some+evidence+of+effects+of+environmental+chemicals+on+the+endocrine+system+in+children.&rft.au=Rogan%2C+Walter+J%3BRagan%2C+N+Beth&rft.aulast=Rogan&rft.aufirst=Walter&rft.date=2007-10-01&rft.volume=210&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=14384639&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview of HIV Vaccines and PAVE-100 T2 - 2007 National HIV Prevention Conference AN - 39643045; 4737038 JF - 2007 National HIV Prevention Conference AU - Kripke, K Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Vaccines KW - Reviews KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39643045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=An+Overview+of+HIV+Vaccines+and+PAVE-100&rft.au=Kripke%2C+K&rft.aulast=Kripke&rft.aufirst=K&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV and Mental Illness: Intervention and Prevention Priorites T2 - 2007 National HIV Prevention Conference AN - 39593008; 4737290 JF - 2007 National HIV Prevention Conference AU - Grossman, C I Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Mental disorders KW - Human immunodeficiency virus KW - Prevention KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=HIV+and+Mental+Illness%3A+Intervention+and+Prevention+Priorites&rft.au=Grossman%2C+C+I&rft.aulast=Grossman&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Drug Web Sites AN - 872124484; 13617740 JF - Toxicologic Pathology AU - Ward, J M AD - , NIH and SoBran, Inc., Bethesda, MD, jw116y@nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1044 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 35 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872124484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Drug+Web+Sites&rft.au=Ward%2C+J+M&rft.aulast=Ward&rft.aufirst=J&rft.date=2007-12-01&rft.volume=35&rft.issue=7&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701756407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1080/01926230701756407 ER - TY - JOUR T1 - A Mycobacterium tuberculosis-Derived Lipid Inhibits Membrane Fusion by Modulating Lipid Membrane Domains AN - 864412733; 14419275 AB - Tuberculosis is an infectious and potentially fatal disease caused by the acid-fast bacillus Mycobacterium tuberculosis (MTB). One hallmark of a tuberculosis infection is the ability of the bacterium to subvert the normal macrophage defense mechanism of the host immune response. Lipoarabinomannan (LAM), an integral component of the MTB cell wall, is released when MTBs are taken into phagosomes and has been reported to be involved in the inhibition of phago-lysosomal (P-L) fusion. However, the physical chemistry of the effects of LAM on lipid membrane structure relative to P-L fusion has not been studied. We produced membranes in vitro composed of dioleoylphosphatidylcholine, sphingomyelin, and cholesterol to simulate phagosomal lipid membranes and quantified the effects of the addition of LAM to these membranes, using fluorescence resonance energy transfer assays and atomic force microscopy. We found that LAM inhibits vesicle fusion and markedly alters lipid membrane domain morphology and sphingomyelin-chollesterol/dioleoylphosphatidylcholine ratios. These data demonstrate that LAM induces a dramatic reorganization of lipid membranes in vitro and clarifies the role of LAM in the inhibition of P-L fusion and the survival of the MTB within the macrophage. JF - Biophysical Journal AU - Hayakawa, Eri AU - Tokumasu, Fuyuki AU - Nardone, Glenn A AU - Jin, Albert J AU - Hackley, Vince A AU - Dvorak, James A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 4018 EP - 4030 PB - Biophysical Society VL - 93 IS - 11 SN - 0006-3495, 0006-3495 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Macrophages KW - Data processing KW - sphingomyelin KW - Membrane fusion KW - Phagosomes KW - atomic force microscopy KW - fluorescence resonance energy transfer KW - Cholesterol KW - Infection KW - Lipid rafts KW - Lipid membranes KW - Tuberculosis KW - Defense mechanisms KW - Immune response KW - Bacillus KW - Lipoarabinomannans KW - Mycobacterium tuberculosis KW - Vesicle fusion KW - Cell walls KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864412733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=A+Mycobacterium+tuberculosis-Derived+Lipid+Inhibits+Membrane+Fusion+by+Modulating+Lipid+Membrane+Domains&rft.au=Hayakawa%2C+Eri%3BTokumasu%2C+Fuyuki%3BNardone%2C+Glenn+A%3BJin%2C+Albert+J%3BHackley%2C+Vince+A%3BDvorak%2C+James+A&rft.aulast=Hayakawa&rft.aufirst=Eri&rft.date=2007-12-01&rft.volume=93&rft.issue=11&rft.spage=4018&rft.isbn=&rft.btitle=&rft.title=Biophysical+Journal&rft.issn=00063495&rft_id=info:doi/10.1529%2Fbiophysj.107.104075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Data processing; sphingomyelin; Membrane fusion; Phagosomes; atomic force microscopy; fluorescence resonance energy transfer; Cholesterol; Infection; Lipid rafts; Lipid membranes; Tuberculosis; Immune response; Defense mechanisms; Lipoarabinomannans; Cell walls; Vesicle fusion; Bacillus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1529/biophysj.107.104075 ER - TY - JOUR T1 - Analysis of auditory phenotype and karyotype in 200 females with Turner syndrome. AN - 85408387; pmid-17982369 AB - Turner syndrome is the most common sex chromosome disorder in females, and is caused by a total or partial deletion of one X chromosome. The purpose of this study was to describe the auditory phenotype in a large group of individuals with Turner Syndrome, with analysis focusing on hearing loss and age, as well as the phenotypic relationship to karyotype variation.Our analysis of auditory function was part of a large-scale, natural history study in which clinical and genetic factors related to Turner syndrome were examined. This ascertainment avoids the bias inherent in studies of patients referred to audiology or otolaryngology specialty clinics. Analysis included data from 200 females with Turner syndrome ranging in age from 7 to 61 yr (mean=27.9 yr).We observed hearing loss in approximately one-half of females with Turner syndrome, and report on a common, previously unlabeled audiometric configuration found in 24% of ears tested. Our cross-sectional design revealed an observable deterioration in hearing loss above the averaged rate of age-related hearing loss seen in an otologically screened, standardized population. Karyotype analysis revealed air conduction thresholds that were significantly poorer in the 46, XdelXp and 46, XiXq groups than in the 46, XdelXq group.This natural history study provides a more representative description of the auditory phenotype associated with Turner syndrome than previous studies that may have been biased by the method of ascertainment. Correlative analysis of Turner syndrome-specific hearing loss features with karyotype revealed that air conduction threshold elevations are associated with loss of the p arm of chromosome X. Our cross-sectional data indicate a loss of hearing sensitivity at an accelerated rate beyond a normal age-related decline, which warrants continued audiologic monitoring in all females with Turner syndrome regardless of a history of normal hearing. JF - Ear and hearing AU - King, Kelly A AU - Makishima, Tomoko AU - Zalewski, Christopher K AU - Bakalov, Vladimir K AU - Griffith, Andrew J AU - Bondy, Carolyn A AU - Brewer, Carmen C AD - Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 831 EP - 841 VL - 28 IS - 6 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Child KW - Chromosome Deletion KW - Chromosomes, Human, X KW - Female KW - Gene Frequency KW - Genetic Predisposition to Disease KW - *Hearing KW - Humans KW - Karyotyping KW - Male KW - Middle Aged KW - Phenotype KW - *Turner Syndrome: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85408387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Analysis+of+auditory+phenotype+and+karyotype+in+200+females+with+Turner+syndrome.&rft.au=King%2C+Kelly+A%3BMakishima%2C+Tomoko%3BZalewski%2C+Christopher+K%3BBakalov%2C+Vladimir+K%3BGriffith%2C+Andrew+J%3BBondy%2C+Carolyn+A%3BBrewer%2C+Carmen+C&rft.aulast=King&rft.aufirst=Kelly&rft.date=2007-12-01&rft.volume=28&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normal hearing in alpha-galactosidase A-deficient mice, the mouse model for Fabry disease. AN - 85407587; pmid-17933476 AB - Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the alpha-galactosidase gene (Gla). Loss of Gla activity leads to the abnormal accumulation of glycosphingolipids in lysosomes of predominantly vascular endothelial cells. Clinically the disorder presents with angiokeratomas, clouding of the cornea, and renal, cardiac, and cerebrovascular complications. In addition, there is an increased incidence of sensorineural hearing loss in Fabry patients. In this study, we investigated the loss of alpha-galactosidase A activity on hearing function in Gla-deficient mice (Gla(tm1Kul)). Gla mRNA was readily detected in the cochlea of 2- and 12-month old C57BL/6J and C3HeB/FeJ mice. The targeted allele was introgressed to the normal hearing C3HeB/FeJ strain to eliminate confounding genetic background effects. Auditory brain stem responses (ABR) to click, 8-, 16-, and 32 kHz stimuli measured at regular intervals from animals at the N4 backcross generation and from N4F1 hybrids demonstrated normal hearing in hemizygous and homozygous mutant mice up to 76 weeks of age. By histological criteria, the cyto-architecture of the mutant cochlea showed a normal appearance. The data demonstrate that in the mouse the loss of alpha-galactosidase A activity is genetically or biochemically buffered and not sufficient per se to cause an appreciable degree of hearing impairment. JF - Hearing research AU - Noben-Trauth, Konrad AU - Neely, Harold AU - Brady, Roscoe O AD - Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20855, USA. nobentk@nidcd.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 10 EP - 14 VL - 234 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Animals KW - Cochlea: enzymology KW - Cochlea: pathology KW - *Cochlea: physiopathology KW - Disease Models, Animal KW - Evoked Potentials, Auditory, Brain Stem KW - Fabry Disease: complications KW - Fabry Disease: enzymology KW - Fabry Disease: genetics KW - *Fabry Disease: physiopathology KW - Female KW - *Hearing KW - Hearing Loss: enzymology KW - Hearing Loss: etiology KW - Hearing Loss: physiopathology KW - Male KW - Mice KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Mice, Knockout KW - RNA, Messenger: metabolism KW - Time Factors KW - alpha-Galactosidase: genetics KW - *alpha-Galactosidase: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85407587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Human+Gene+Therapy&rft.atitle=Prolonged+Reduction+of+CCR5+Expression+in+Multiple+Hematopoietic+Cell+Lineages+by+RNA+Interference+Through+CD34%2B+Cell+Transplant+in+Non-Human+Primates&rft.au=Donahue%2C+R%3BAn%2C+D-S%3BKamata%2C+M%3BMattapallil%2C+J%3BPoon%2C+B%3BMetzger%2C+M%3BMao%2C+S-H%3BBonifacino%2C+A%3BKrouse%2C+A%3BDarlix%2C+J-L%3BBaltimore%2C+D%3BQin%2C+FX-F%3BChen%2C+ISY&rft.aulast=Donahue&rft.aufirst=R&rft.date=2007-10-01&rft.volume=18&rft.issue=10&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Perceived ambiguity about cancer prevention recommendations: associations with cancer-related perceptions and behaviours in a US population survey AN - 746156604; 7983280 AB - Background Health information reaching the public today is often characterized by what decision theorists have termed 'ambiguity'- i.e. uncertainty regarding the information's reliability, credibility or adequacy. This is a critical problem, as growing research suggests that ambiguity has important effects-promoting pessimistic judgments about risks and potential outcomes of risk-reducing behaviours, and lowering adoption of these behaviours. However, little is known about the public's perceptions of ambiguity in the health information domain, the effects of these perceptions, and the factors that influence these effects. Objective To examine associations between perceived ambiguity regarding cancer prevention recommendations and prevention-related perceptions and behaviours, and to explore how these associations differ by cancer type. Study design and participants Cross-sectional analysis of data on 4070 adults participating in the 2005 US Health Information National Trends Survey. Main variables and outcome measures We examined associations between perceived ambiguity about colon, skin and lung cancer prevention recommendations and two main outcome variables: (i) risk-related cognitions (perceived cancer risk and preventability, cancer-related worry) and (ii) risk-modifying behaviours (colon cancer screening, sunscreen use and smoking abstinence). Results Perceived ambiguity was inversely associated with perceptions of the preventability of all three cancers, and with cancer-specific risk-modifying behaviours including sigmoidoscopy-colonoscopy testing, sunscreen use and smoking abstinence. Relationships with cancer risk perceptions and worry varied across different cancer types. Conclusions Perceived ambiguity about cancer prevention recommendations has significant and predictable associations with cancer prevention-related cognitions and behaviours, and some associations differ by cancer type. These findings have implications for future research and communication efforts. JF - Health Expectations AU - Han, Paul KJ AU - Moser, Richard P AU - Klein, William MP AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA, hanp@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 321 EP - 336 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 4 SN - 1369-6513, 1369-6513 KW - Risk Abstracts KW - ambiguity KW - cancer prevention KW - health behaviours KW - perceptions KW - recommendations KW - sexual behavior KW - Skin KW - Cancer KW - Public opinion KW - Smoking KW - risk reduction KW - USA KW - cognitive ability KW - Communications KW - Perception KW - prevention KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746156604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Perceived+ambiguity+about+cancer+prevention+recommendations%3A+associations+with+cancer-related+perceptions+and+behaviours+in+a+US+population+survey&rft.au=Han%2C+Paul+KJ%3BMoser%2C+Richard+P%3BKlein%2C+William+MP&rft.aulast=Han&rft.aufirst=Paul&rft.date=2007-12-01&rft.volume=10&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2007.00456.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Public opinion; risk reduction; Smoking; sexual behavior; Skin; Communications; cognitive ability; Perception; prevention; Cancer; Lung cancer; USA DO - http://dx.doi.org/10.1111/j.1369-7625.2007.00456.x ER - TY - JOUR T1 - Tobacco use amongst children in Karnataka AN - 746084987; 13021557 AB - Objective To estimate the prevalence, pattern and correlates of tobacco use amongst the 13-15 year olds in schools of Karnataka Methods A three stage (area, school level and class level) cluster sample design was adopted and 80 schools from 12 districts of the statewere selected. A total of 4,110 students participated in the study with an overall response rate of 87%. Results Point prevalence of tobacco use amongst 13-15 year old was 4.9%. Current tobacco use was predominantly a male feature and use of smokeless variety predominated (transitional Kamataka (8.2%); metropolis (6.8%); rural (3.4%). One third of current tobacco users (30.8%) purchased tobacco product in a store and one-fifth used it at home. Nearly half of the never smokers (43% to 56.7%) were exposed to tobacco smoke outside home and 83% favored a ban on smoking in public places. A male tobacco user was perceived to have more friends and was reported to make them look attractive. Print media was a predominant source of message, more so in the metropolitan region. Only one-third (31.6%) reported that the reasons of tobacco usage amongst youth was discussed in formal school settings. Conclusion GYTS Kamataka has provided reliable estimates and shown the feasibility of implementing a surveillance programme. Specific challenges for Public health that emerge from the study are increasing number of users in transitional areas, continued media exposure, tobacco users being perceived to be popular and attractive, easy and relatively unrestricted access, lack of systematic support within schools and social acceptance of tobacco use at home. The need of the hour is to target and focus interventions through comprehensive programmes aimed at children, school authorities, parents and policy makers. JF - Indian Journal of Pediatrics AU - Gururaj, G AU - Girish, N AD - Department of Epidemiology, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India, guru@nimhans.kar.nic.in Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1095 EP - 1098 VL - 74 IS - 12 SN - 0019-5456, 0019-5456 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Pediatrics&rft.atitle=Tobacco+use+amongst+children+in+Karnataka&rft.au=Gururaj%2C+G%3BGirish%2C+N&rft.aulast=Gururaj&rft.aufirst=G&rft.date=2007-12-01&rft.volume=74&rft.issue=12&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Pediatrics&rft.issn=00195456&rft_id=info:doi/10.1007%2FS12098-007-0204-X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1007/S12098-007-0204-X ER - TY - JOUR T1 - Evaluation of dimethoxydop-NU as a novel anti-tumor agent. AN - 70116562; 18365543 AB - Dimethoxydop-NU, 1-[2-{3-(2-Chloroethyl)-3-nitrosoureido}ethyl]-3,4-dimethoxy-benzene (Compound 1), was synthesized from 3,4-dimethoxy-phenethylamine as a novel anti-tumor agent based on the structures of the clinical drug CCNU and dopamine, an important endogenous biological amine having anti-angiogenesis property. In vitro screening in two human tumor cell lines, namely promyelocytic leukemia HL-60 and histiocytic lymphoma U-937, revealed its cytotoxicity greater than that of hydroxyurea and comparable to BCNU used as standards. Its in vivo anti-tumoral potency was assessed in the murine ascites tumors Sarcoma-180 (S-180) and Ehrlich ascites carcinoma (EAC) by measuring the increase in median survival times of drug treated (T) over untreated control (C) mice. Results revealed significant tumor regression effects in these tumors. The survival time of treated mice was markedly increased by combination of the compound 1 with dopamine hydrochloride. Its toxicity was assessed in vivo in normal and EAC bearing mice by measuring drug-induced changes in hematological parameters, femoral bone marrow and splenic cellularities as well as biochemical parameters sequentially on days 9, 14 and 19 following drug treatment at the optimum dose of 30 mg/kg from day 1 to 7. Results indicated that initial suppression in the femoral bone marrow cellularity seen on day 9 reached normalcy by day 19. Other parameters were within normal limit. Histopathological studies of liver revealed mild hepatotoxicity on day 9 in treated groups that substantially recovered on day 19. Similar studies with heart and kidney revealed no cardio toxicity or nephrotoxicity. Compound 1 comparable to standards inhibited the synthesis of DNA and RNA in S-180 tumor cells. JF - Journal of experimental & clinical cancer research : CR AU - Mukherjee, A AU - Dutta, S AU - Sanyal, U AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 489 EP - 497 VL - 26 IS - 4 SN - 0392-9078, 0392-9078 KW - 1-(2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)-3,4-dimethoxy-benzene KW - 0 KW - Antineoplastic Agents KW - Nitrosourea Compounds KW - Thymidine KW - VC2W18DGKR KW - Uridine KW - WHI7HQ7H85 KW - Index Medicus KW - Thymidine -- metabolism KW - Drug Screening Assays, Antitumor KW - Animals KW - Humans KW - Uridine -- metabolism KW - Mice KW - Cell Line, Tumor KW - Drug Evaluation, Preclinical KW - Nitrosourea Compounds -- pharmacology KW - Nitrosourea Compounds -- chemical synthesis KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70116562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=Evaluation+of+dimethoxydop-NU+as+a+novel+anti-tumor+agent.&rft.au=Mukherjee%2C+A%3BDutta%2C+S%3BSanyal%2C+U&rft.aulast=Mukherjee&rft.aufirst=A&rft.date=2007-12-01&rft.volume=26&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=03929078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-11 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder. AN - 70106862; 18315448 AB - Obsessive-compulsive disorder (OCD) in childhood is often refractory to treatment. Riluzole, a glutamate antagonist, has theoretical support as an alternative pharmacological treatment and has demonstrated possible benefit in some open-label trials in adults with OCD. Six subjects, ages 8-16 years, were enrolled in a 12-week open-label trial of riluzole for OCD symptoms that had resisted prior treatments. OCD symptoms and adverse effects of drug were monitored. Four of 6 subjects had clear benefit, with reduction of more than 46% (39% overall) on Children's Yale-Brown Obsessive-Compulsive Scale, and "Much Improved" or "Very Much Improved" on the Clinical Global Impressions-Improvement scale. Two subjects had no clinically meaningful change in symptom severity by 12 weeks, but 1 subject improved thereafter. There were no adverse effects of drug sufficient to cause discontinuation or reduction of dose. All subjects elected to continue riluzole after the 12-week trial. Riluzole may be beneficial for treatment-resistant OCD in young subjects and seems well tolerated. A placebo-controlled trial of the drug is planned. JF - Journal of child and adolescent psychopharmacology AU - Grant, Paul AU - Lougee, Lorraine AU - Hirschtritt, Matthew AU - Swedo, Susan E AD - Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. paul.grant@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 761 EP - 767 VL - 17 IS - 6 SN - 1044-5463, 1044-5463 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Riluzole KW - 7LJ087RS6F KW - Index Medicus KW - Severity of Illness Index KW - Psychiatric Status Rating Scales KW - Humans KW - Treatment Outcome KW - Drug Resistance KW - Child KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Riluzole -- adverse effects KW - Excitatory Amino Acid Antagonists -- therapeutic use KW - Obsessive-Compulsive Disorder -- drug therapy KW - Excitatory Amino Acid Antagonists -- adverse effects KW - Riluzole -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70106862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=An+open-label+trial+of+riluzole%2C+a+glutamate+antagonist%2C+in+children+with+treatment-resistant+obsessive-compulsive+disorder.&rft.au=Grant%2C+Paul%3BLougee%2C+Lorraine%3BHirschtritt%2C+Matthew%3BSwedo%2C+Susan+E&rft.aulast=Grant&rft.aufirst=Paul&rft.date=2007-12-01&rft.volume=17&rft.issue=6&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/10.1089%2Fcap.2007.0021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00251303; ClinicalTrials.gov N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/cap.2007.0021 ER - TY - JOUR T1 - Buprenorphine and norbuprenorphine in hair of pregnant women and their infants after controlled buprenorphine administration. AN - 70101713; 17921260 AB - Buprenorphine is under investigation as a pharmacotherapeutic agent for treating opioid dependence in pregnant women. We hypothesized that there would be a relationship between the cumulative maternal dose of buprenorphine during pregnancy and the concentration of buprenorphine and norbuprenorphine in maternal and infant hair. This study examined buprenorphine and norbuprenorphine concentrations in hair obtained from 9 buprenorphine-maintained pregnant women and 4 of their infants. Specimens were analyzed by liquid chromatography-tandem mass spectrometry with limits of quantification of 3.0 pg/mg. All maternal hair specimens were washed with methylene chloride before analysis, and when sufficient amounts of maternal hair were available, specimens also were analyzed without washing. Infant hair specimens were not washed. Buprenorphine concentrations were significantly greater in unwashed hair than washed hair (P = 0.031). Norbuprenorphine concentrations were significantly greater than buprenorphine concentrations in both maternal (P = 0.0097) and infant hair (P = 0.0033). There were statistically significant associations between the cumulative maternal dose of buprenorphine administered and the concentrations of buprenorphine (washed, P <0.0001; unwashed, P = 0.0004), norbuprenorphine (washed, P <0.0001; unwashed, P = 0.0005), and buprenorphine plus norbuprenorphine (washed, P <0.0001; unwashed, P = 0.0005) for both washed and unwashed maternal hair specimens. There was a significant positive association between concentrations of buprenorphine and norbuprenorphine in maternal hair (washed, P <0.0001; unwashed, P = 0.0003), a trend for this association in infant hair (P = 0.08), and an association between buprenorphine concentrations in maternal unwashed hair and infant hair (P = 0.0002). The buprenorphine:norbuprenorphine ratio increased in distal segments. Buprenorphine treatment during gestation provides an opportunity for monitoring drug disposition in maternal and fetal tissues under controlled conditions. JF - Clinical chemistry AU - Goodwin, Robert S AU - Wilkins, Diana G AU - Averin, Olga AU - Choo, Robin E AU - Schroeder, Jennifer R AU - Jasinski, Donald R AU - Johnson, Rolley E AU - Jones, Hendrée E AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2136 EP - 2143 VL - 53 IS - 12 SN - 0009-9147, 0009-9147 KW - Receptors, Opioid, kappa KW - 0 KW - Receptors, Opioid, mu KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Index Medicus KW - Infant KW - Receptors, Opioid, mu -- agonists KW - Humans KW - Receptors, Opioid, kappa -- antagonists & inhibitors KW - Adult KW - Infant, Newborn KW - Chromatography, Liquid KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Female KW - Pregnancy KW - Buprenorphine -- analysis KW - Pregnancy Complications -- metabolism KW - Buprenorphine -- therapeutic use KW - Heroin Dependence -- metabolism KW - Heroin Dependence -- drug therapy KW - Hair -- chemistry KW - Buprenorphine -- pharmacokinetics KW - Pregnancy Complications -- drug therapy KW - Buprenorphine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70101713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Buprenorphine+and+norbuprenorphine+in+hair+of+pregnant+women+and+their+infants+after+controlled+buprenorphine+administration.&rft.au=Goodwin%2C+Robert+S%3BWilkins%2C+Diana+G%3BAverin%2C+Olga%3BChoo%2C+Robin+E%3BSchroeder%2C+Jennifer+R%3BJasinski%2C+Donald+R%3BJohnson%2C+Rolley+E%3BJones%2C+Hendr%C3%A9e+E%3BHuestis%2C+Marilyn+A&rft.aulast=Goodwin&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=53&rft.issue=12&rft.spage=2136&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-10 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1. AN - 70058103; 18199852 AB - Drug interactions and drug specificity are core themes for the pharmacologist. The paper discussed in this Viewpoint exploits the former to attain the latter. How can one improve local anesthetics so that they block pain but permit normal sensation? QX-314 is a charged derivative of lidocaine without anesthetic activity because it cannot diffuse across the cell membrane to access the neuronal voltage-dependent sodium channel. Capsaicin is a selective activator of the TRPV1 channel, the localization of which is restricted to sensory C-fiber neurons involved in nociception. Because the large pore size of the activated TRPV1 allows passage of large cations such as QX-314, combined treatment with capsaicin and QX-314 puts QX-314 uniquely into that subclass of neurons mediating pain, thereby achieving sensational specificity. JF - Molecular interventions AU - Blumberg, Peter M AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. blumberp@dc37a.nci.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 310 EP - 312 VL - 7 IS - 6 SN - 1534-0384, 1534-0384 KW - Sodium Channel Blockers KW - 0 KW - TRPV Cation Channels KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Animals KW - Drug Interactions KW - Neurons, Afferent -- chemistry KW - Models, Molecular KW - Humans KW - Neurons, Afferent -- drug effects KW - Models, Neurological KW - Capsaicin -- administration & dosage KW - Sodium Channel Blockers -- administration & dosage KW - Neurons, Afferent -- physiology KW - TRPV Cation Channels -- chemistry KW - TRPV Cation Channels -- agonists KW - TRPV Cation Channels -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70058103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=MAC1+mediates+LPS-induced+production+of+superoxide+by+microglia%3A+the+role+of+pattern+recognition+receptors+in+dopaminergic+neurotoxicity.&rft.au=Pei%2C+Zhong%3BPang%2C+Hao%3BQian%2C+Li%3BYang%2C+Sufen%3BWang%2C+Tonggauang%3BZhang%2C+Wei%3BWu%2C+Xeufei%3BDallas%2C+Shannon%3BWilson%2C+Belinda%3BReece%2C+Jeffrey+M%3BMiller%2C+David+S%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Pei&rft.aufirst=Zhong&rft.date=2007-10-01&rft.volume=55&rft.issue=13&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mi.7.6.5 ER - TY - JOUR T1 - Xerostomia: causes and treatment. AN - 70053453; 18198958 AB - When reduced salivary flow causes perpetual dry and sticky mucosa or sticky, stringy saliva, it becomes xerostomia-not a disease, but a symptom. Up to 30% of various populations self-report dry mouth (xerostomia) or have proven low salivary flow rates. Saliva is necessary for digestion and dental health, and it may have yet-unidentified immunological roles in humans. Xerostomia can lead to digestive problems, weight loss, and accelerated dental decay. Medications-several hundred of them-can cause or exacerbate xerostomia. Cancer, autoimmune diseases, and bone marrow transplants are associated with xerostomia. Including a dentist on the treatment team is essential for residents with dry mouth. As xerostomia progresses, they should shift focus primarily to prevention, maintenance, oral comfort, and emergency treatment. In all stages, they should keep treatment noninvasive if possible. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeanette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 985 EP - 992 VL - 22 IS - 12 SN - 0888-5109, 0888-5109 KW - Quinuclidines KW - 0 KW - Thiophenes KW - Pilocarpine KW - 01MI4Q9DI3 KW - cevimeline KW - K9V0CDQ56E KW - Index Medicus KW - Thiophenes -- therapeutic use KW - Pilocarpine -- therapeutic use KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Bone Marrow Transplantation -- adverse effects KW - Saliva -- secretion KW - Quinuclidines -- therapeutic use KW - Autoimmune Diseases -- complications KW - Xerostomia -- etiology KW - Xerostomia -- metabolism KW - Xerostomia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70053453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Xerostomia%3A+causes+and+treatment.&rft.au=Wick%2C+Jeanette+Y&rft.aulast=Wick&rft.aufirst=Jeanette&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of nanoparticles for therapeutics. AN - 69086343; 18095846 AB - Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy. JF - Nanomedicine (London, England) AU - Hall, Jennifer B AU - Dobrovolskaia, Marina A AU - Patri, Anil K AU - McNeil, Scott E AD - SAIC-Frederick Inc., Nanotechnology Characterization Laboratory, Advanced Technology Program, NCI-Frederick, 1050 Boyles St., Bldg. 469, Frederick, MD 21702, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 789 EP - 803 VL - 2 IS - 6 KW - Drug Carriers KW - 0 KW - Index Medicus KW - Nanomedicine -- trends KW - Chemistry, Pharmaceutical -- trends KW - Nanoparticles -- therapeutic use KW - Nanoparticles -- ultrastructure KW - Drug Carriers -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+pharmacotherapy&rft.atitle=Clinical+pharmacology+of+antifungal+agents+in+pediatric+patients.&rft.au=Chiou%2C+Christine+C%3BWalsh%2C+Thomas+J%3BGroll%2C+Andreas+H&rft.aulast=Chiou&rft.aufirst=Christine&rft.date=2007-10-01&rft.volume=8&rft.issue=15&rft.spage=2465&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+pharmacotherapy&rft.issn=1744-7666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective study of red and processed meat intake in relation to cancer risk. AN - 69086300; 18076279 AB - Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites. The National Institutes of Health (NIH)-AARP (formerly the American Association for Retired Persons) Diet and Health Study is a cohort of approximately 500,000 people aged 50-71 y at baseline (1995-1996). Meat intake was estimated from a food frequency questionnaire administered at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals within quintiles of red and processed meat intake. During up to 8.2 y of follow-up, 53,396 incident cancers were ascertained. Statistically significant elevated risks (ranging from 20% to 60%) were evident for esophageal, colorectal, liver, and lung cancer, comparing individuals in the highest with those in the lowest quintile of red meat intake. Furthermore, individuals in the highest quintile of processed meat intake had a 20% elevated risk for colorectal and a 16% elevated risk for lung cancer. Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancers of the esophagus and liver. JF - PLoS medicine AU - Cross, Amanda J AU - Leitzmann, Michael F AU - Gail, Mitchell H AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. crossa@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1 VL - 4 IS - 12 KW - Index Medicus KW - Sex Factors KW - Nutrition Assessment KW - Humans KW - Aged KW - Risk Assessment KW - Lung Neoplasms -- etiology KW - Prospective Studies KW - Risk Factors KW - Surveys and Questionnaires KW - Colorectal Neoplasms -- etiology KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Esophageal Neoplasms -- etiology KW - Liver Neoplasms -- etiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Proportional Hazards Models KW - Meat Products -- adverse effects KW - Meat -- adverse effects KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=A+prospective+study+of+red+and+processed+meat+intake+in+relation+to+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BLeitzmann%2C+Michael+F%3BGail%2C+Mitchell+H%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=e325&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 2004;48(2):149-59 [15231449] Natl Cancer Inst Monogr. 1979 Nov;(53):149-55 [537622] J Natl Cancer Inst. 1985 Oct;75(4):645-54 [3862897] Am J Epidemiol. 1985 Dec;122(6):947-59 [2998182] Am J Epidemiol. 1986 Dec;124(6):894-902 [3776972] Cancer. 1988 Jun 15;61(12):2578-85 [3365678] Am J Epidemiol. 1988 Aug;128(2):324-36 [3394699] Nutr Cancer. 1988;11(4):243-50 [3217262] Int J Cancer. 1989 Oct 15;44(4):611-6 [2793233] Nutr Cancer. 1989;12(4):333-41 [2608538] Cancer Res. 1990 Feb 1;50(3):627-31 [2297702] Acta Pathol Jpn. 1989 Nov;39(11):725-30 [2618659] Cancer Res. 1990 Nov 1;50(21):6836-40 [2208150] Methods Enzymol. 1990;186:1-85 [2172697] Cancer Res. 1990 Dec 1;50(23):7501-4 [2253198] Cancer. 1991 Aug 1;68(3):672-8 [2065291] Cancer Causes Control. 1991 Jul;2(4):227-33 [1873452] Int J Cancer. 1991 Oct 21;49(4):513-9 [1917151] J Appl Bacteriol. 1992 Jan;72(1):57-64 [1541601] Epidemiology. 1992 Jul;3(4):288-99 [1637893] Cancer Causes Control. 1992 Sep;3(5):441-8 [1525325] J Natl Cancer Inst. 1993 Oct 6;85(19):1571-9 [8105097] Int J Cancer. 2006 Jun 1;118(11):2871-6 [16385566] Int J Cancer. 2006 Jun 1;118(11):2866-70 [16385571] Int J Cancer. 2006 Dec 1;119(11):2657-64 [16991129] Am J Clin Nutr. 2006 Nov;84(5):1177-83 [17093172] Arch Intern Med. 2006 Nov 13;166(20):2253-9 [17101944] Br J Cancer. 2006 Dec 4;95(11):1586-92 [17060930] Leuk Lymphoma. 2006 Dec;47(12):2477-87 [17169793] Cancer Causes Control. 2007 Mar;18(2):125-33 [17242980] Cancer Causes Control. 2007 Feb;18(1):41-50 [17315319] J Natl Cancer Inst. 2007 Mar 21;99(6):451-62 [17374835] Br J Cancer. 2007 Apr 10;96(7):1139-46 [17406351] Cancer Causes Control. 2007 Jun;18(5):551-60 [17437180] Public Health Nutr. 2008 Feb;11(2):183-95 [17610761] J Natl Cancer Inst. 1999 Oct 20;91(20):1751-8 [10528026] Int J Cancer. 2000 May 1;86(3):425-8 [10760833] Cancer Res. 2000 Jul 15;60(14):3753-6 [10919646] Am J Epidemiol. 2000 Aug 1;152(3):279-86 [10933275] Gut. 2000 Sep;47(3):362-5 [10940272] Cancer Causes Control. 2000 Dec;11(10):915-23 [11142526] Cancer Causes Control. 2000 Dec;11(10):965-74 [11142531] Carcinogenesis. 2001 Jan;22(1):199-202 [11159760] Oral Oncol. 2001 Feb;37(2):141-5 [11167140] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] Nutr Rev. 2001 May;59(5):140-8 [11396694] Br J Cancer. 2001 Jul 6;85(1):46-54 [11437401] Cancer Causes Control. 2001 Aug;12(6):557-67 [11519764] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Ann Epidemiol. 1993 May;3(3):211-6 [8275191] J Natl Cancer Inst. 1994 Feb 16;86(4):281-6 [8158682] Cancer Causes Control. 1994 Mar;5(2):195-202 [8167267] Am J Public Health. 1994 Jul;84(7):1086-93 [8017530] Epidemiology. 1994 May;5(3):276-82 [8038241] Cancer Causes Control. 1994 Sep;5(5):422-32 [7999964] Cancer Causes Control. 1999 Oct;10(5):355-67 [10530605] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):512-20 [15734980] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2261-5 [16172241] J Natl Cancer Inst. 2005 Oct 5;97(19):1458-65 [16204695] Cancer Res. 2005 Dec 15;65(24):11779-84 [16357191] J Natl Cancer Inst. 2006 Mar 1;98(5):345-54 [16507831] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Int J Epidemiol. 2002 Feb;31(1):78-85 [11914299] Int J Cancer. 2002 Mar 20;98(3):480-2 [11920604] Am J Epidemiol. 2002 May 1;155(9):783-92 [11978580] Br J Cancer. 2002 Jul 1;87(1):37-42 [12085253] Int J Cancer. 2002 Jul 20;100(3):355-60 [12115553] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Int J Cancer. 2002 Nov 20;102(3):207-11 [12397637] J Nutr. 2002 Nov;132(11 Suppl):3526S-3529S [12421882] Br J Cancer. 2002 Nov 18;87(11):1230-3 [12439711] Am J Epidemiol. 2003 Mar 1;157(5):434-45 [12615608] Eur J Cancer Prev. 2003 Apr;12(2):135-43 [12671537] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 2003 Jun 15;157(12):1115-25 [12796048] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):513-8 [8268766] J Natl Cancer Inst. 1995 May 3;87(9):652-61 [7752270] Biochem Biophys Res Commun. 1995 May 16;210(2):350-5 [7755610] J Urol. 1996 Mar;155(3):969-74 [8583620] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):895-9 [8634663] JAMA. 1996 May 1;275(17):1315-21 [8614116] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):161-6 [8833615] Princess Takamatsu Symp. 1995;23:232-9 [8844814] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] Nutr Cancer. 1997;27(3):256-60 [9101555] Med Sci Sports Exerc. 1997 Jun;29(6 Suppl):S1-205 [9243481] Cancer Res. 1997 Nov 15;57(22):5077-85 [9371506] Int J Cancer. 1997 Nov 27;73(5):634-8 [9398038] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Int J Cancer. 1998 May 29;76(5):659-64 [9610722] Hepatology. 1998 Jun;27(6):1563-6 [9620327] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Leuk Res. 1998 May;22(5):445-52 [9652731] J Med Microbiol. 1998 May;47(5):407-16 [9879941] Eur J Cancer Prev. 1998 Dec;7(6):455-60 [9926293] Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):25-34 [9950236] Toxicol Lett. 1998 Dec 28;102-103:441-6 [10022293] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Am J Epidemiol. 1999 May 15;149(10):925-32 [10342801] Br J Cancer. 1999 Jun;80(7):1107-13 [10362125] Gut. 1999 Jul;45(1):45-50 [10369703] Br J Cancer. 1999 May;80(3-4):591-7 [10408871] Cancer Lett. 1999 Sep 1;143(2):149-55 [10503895] Cancer Causes Control. 2003 Jun;14(5):427-38 [12946037] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):940-4 [14504209] Neuroepidemiology. 2004 Jan-Apr;23(1-2):78-84 [14739572] Am J Epidemiol. 2004 Mar 1;159(5):454-66 [14977641] Int J Cancer. 2004 Jun 20;110(3):424-8 [15095309] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Comment In: PLoS Med. 2007 Dec;4(12):e345 [18076281] Comment On: PLoS Med. 2007 Dec;4(12):e354 [18076283] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. AN - 69079717; 18098034 AB - Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology Program completed a series of two-year bioassays which were conducted using female Harlan Sprague-Dawley rats. The rats were treated orally for up to 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and a ternary mixture of TCDD, PCB126 and PeCDF. In addition to treatment-related effects reported in other organs, a variety of pulmonary lesions were observed that were related to exposure. Pulmonary CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was increased in all dosed groups. The most common non-neoplastic lesions, which occurred in all studies, were bronchiolar metaplasia and squamous metaplasia of the alveolar epithelium. Cystic keratinizing epithelioma was the most commonly observed neoplasm which occurred in all studies. A low incidence of squamous cell carcinoma was associated only with PCB126 treatment. Potential mechanisms leading to altered differentiation and/or proliferation of bronchiolar and alveolar epithelia may be through CYP1A1 induction or disruption of retinoid metabolism. JF - Toxicologic pathology AU - Walker, Nigel J AU - Yoshizawa, Katsuhiko AU - Miller, Rodney A AU - Brix, Amy E AU - Sells, Donald M AU - Jokinen, Micheal P AU - Wyde, Michael E AU - Easterling, Michael AU - Nyska, Abraham AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. walker3@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 880 EP - 889 VL - 35 IS - 7 SN - 0192-6233, 0192-6233 KW - Benzofurans KW - 0 KW - Polychlorinated Dibenzodioxins KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - 3,4,5,3',4'-pentachlorobiphenyl KW - TSH69IA9XF KW - 2,3,4,7,8-pentachlorodibenzofuran KW - U4C2RV3124 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Metaplasia KW - Time Factors KW - Female KW - Cytochrome P-450 CYP1A1 -- physiology KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Dibenzodioxins -- toxicity KW - Lung -- drug effects KW - Lung -- pathology KW - Benzofurans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69079717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Pulmonary+lesions+in+female+Harlan+Sprague-Dawley+rats+following+two-year+oral+treatment+with+dioxin-like+compounds.&rft.au=Walker%2C+Nigel+J%3BYoshizawa%2C+Katsuhiko%3BMiller%2C+Rodney+A%3BBrix%2C+Amy+E%3BSells%2C+Donald+M%3BJokinen%2C+Micheal+P%3BWyde%2C+Michael+E%3BEasterling%2C+Michael%3BNyska%2C+Abraham&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2007-12-01&rft.volume=35&rft.issue=7&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 1996 Sep;140(1):173-9 [8806883] Toxicol Appl Pharmacol. 1995 Oct;134(2):222-8 [7570598] Annu Rev Cell Dev Biol. 1996;12:55-89 [8970722] IARC Monogr Eval Carcinog Risks Hum. 1997;69:1-631 [9379504] Teratog Carcinog Mutagen. 1997-1998;17(4-5):249-56 [9508734] Exp Toxicol Pathol. 1997 Dec;49(6):433-46 [9495643] Toxicol Sci. 1998 Jan;41(1):62-76 [9520342] Toxicol Pathol. 1998 Mar-Apr;26(2):298-300 [9547872] Environ Health Perspect. 1998 Dec;106(12):775-92 [9831538] Drug Metab Dispos. 1998 Dec;26(12):1194-8 [9860927] Fukuoka Igaku Zasshi. 1999 May;90(5):231-7 [10396879] Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004 Jul;148(1):3-10 [15523539] Toxicol Sci. 2005 Jan;83(1):64-77 [15509667] Environ Health Perspect. 2005 Jan;113(1):43-8 [15626646] Toxicol Pathol. 2005;33(3):371-7 [15805076] Toxicol Sci. 2005 May;85(1):594-606 [15716480] Natl Toxicol Program Tech Rep Ser. 2006 Jan;(520):4-246 [16628245] Mol Nutr Food Res. 2006 Oct;50(10):934-44 [16977594] Natl Toxicol Program Tech Rep Ser. 2006 Sep;(525):1-198 [17160103] Toxicol Pathol. 2007 Jan;35(1):170-7 [17325986] Natl Toxicol Program Tech Rep Ser. 2006 Sep;(526):1-180 [17342195] Toxicol Appl Pharmacol. 2000 Jun 15;165(3):184-94 [10860868] Toxicol Pathol. 2000 Nov-Dec;28(6):761-9 [11127289] Am J Epidemiol. 2001 Jun 1;153(11):1031-44 [11390319] Toxicol Sci. 2001 Jul;62(1):166-75 [11399804] Am J Epidemiol. 2001 Sep 1;154(5):451-8 [11532787] Teratog Carcinog Mutagen. 2001;21(6):395-403 [11746253] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] Toxicol Sci. 2002 Oct;69(2):409-23 [12377990] Annu Rev Pharmacol Toxicol. 2003;43:309-34 [12540743] Arch Toxicol. 2003 Jul;77(7):371-83 [12851740] Ind Health. 2003 Jul;41(3):127-38 [12916742] Chemosphere. 2004 Mar;54(9):1329-36 [14659426] Life Sci. 2004 Jan 9;74(8):1039-49 [14672759] Toxicol Pathol. 2004 Jan-Feb;32(1):41-9 [14713547] Environ Health Perspect. 2004 Jun;112(8):903-9 [15175180] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Cardiovasc Toxicol. 2003;3(4):299-310 [14734827] Toxicol Pathol. 2004 May-Jun;32(3):333-7 [15204975] Regul Toxicol Pharmacol. 2004 Aug;40(1):28-41 [15265604] Biometrics. 1977 Jun;33(2):386-9 [884197] Toxicol Appl Pharmacol. 1978 Nov;46(2):279-303 [734660] J Toxicol Environ Health. 1980 Jan;6(1):27-43 [7381973] Annu Rev Pharmacol Toxicol. 1982;22:517-54 [6282188] Prog Clin Biol Res. 1984;137:19-30 [6425851] Biometrics. 1986 Mar;42(1):183-6 [3719054] Environ Res. 1986 Oct;41(1):144-67 [3757966] Dev Toxicol Environ Sci. 1986;13:459-70 [2435503] Am J Physiol. 1990 Aug;259(2 Pt 1):L38-46 [2200283] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] J Biochem Toxicol. 1990 Winter;5(4):211-9 [2096217] Fukuoka Igaku Zasshi. 1991 May;82(5):251-5 [1916596] J Nutr Sci Vitaminol (Tokyo). 1991 Apr;37(2):117-38 [1919800] Cancer Res. 1992 Nov 15;52(22):6144-52 [1384955] Mol Pharmacol. 1993 Nov;44(5):911-7 [8246913] Cancer Res. 1994 Apr 1;54(7 Suppl):1987s-1990s [8137325] Occup Environ Med. 1994 Jul;51(7):479-86 [8044248] Toxicol Appl Pharmacol. 1994 Aug;127(2):209-21 [8048064] Carcinogenesis. 1994 Oct;15(10):2245-8 [7955061] Chemosphere. 1994 Nov-Dec;29(9-11):2309-13 [7850379] Toxicol Appl Pharmacol. 1995 May;132(1):1-13 [7747272] Carcinogenesis. 1995 Jun;16(6):1345-9 [7788853] Toxicol Pathol. 1996 Sep-Oct;24(5):564-72 [8923677] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. AN - 69078521; 18065489 AB - Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance-linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [(125)I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC(50) values of 7.3 and 22.6 micromol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. JF - Molecular cancer therapeutics AU - Shukla, Suneet AU - Wu, Chung-Pu AU - Nandigama, Krishnamachary AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, National Cancer Institute, MSC 4254, 37 Convent Drive, Bethesda, MD 20892-4256, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3279 EP - 3286 VL - 6 IS - 12 Pt 1 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Naphthoquinones KW - Neoplasm Proteins KW - Photoaffinity Labels KW - Cholecalciferol KW - 1C6V77QF41 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Mitoxantrone KW - BZ114NVM5P KW - plumbagin KW - YAS4TBQ4OQ KW - Index Medicus KW - Humans KW - Adenosine Triphosphate -- metabolism KW - Mitoxantrone -- pharmacology KW - Hydrolysis KW - Cell Line KW - Drug Resistance, Multiple KW - Cholecalciferol -- pharmacology KW - ATP-Binding Cassette Transporters -- metabolism KW - Naphthoquinones -- pharmacology KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69078521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=The+naphthoquinones%2C+vitamin+K3+and+its+structural+analogue+plumbagin%2C+are+substrates+of+the+multidrug+resistance+linked+ATP+binding+cassette+drug+transporter+ABCG2.&rft.au=Shukla%2C+Suneet%3BWu%2C+Chung-Pu%3BNandigama%2C+Krishnamachary%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2007-12-01&rft.volume=6&rft.issue=12+Pt+1&rft.spage=3279&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-19 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2515-20 [10716986] Mol Cell Biol. 2007 Feb;27(4):1247-53 [17145775] Clin Cancer Res. 2000 Nov;6(11):4186-91 [11106230] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Cancer Res. 2001 Apr 15;61(8):3458-64 [11309308] Biochim Biophys Acta. 2001 Jun 6;1512(2):171-82 [11406094] Clin Cancer Res. 2002 Feb;8(2):582-8 [11839680] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Clin Cancer Res. 2003 Feb;9(2):650-6 [12576431] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Mol Pharmacol. 2004 Mar;65(3):675-84 [14978246] Apoptosis. 2004 Mar;9(2):223-33 [15004519] Biochem Pharmacol. 2004 Nov 15;68(10):2043-52 [15476675] Anal Biochem. 1973 Dec;56(2):502-14 [4128882] Science. 1986 May 2;232(4750):643-5 [3457471] Biochem Pharmacol. 1991 May 1;41(9):1283-92 [2018560] Cancer Lett. 1992 Jan 10;61(2):147-56 [1730138] Cancer Res. 1993 Oct 1;53(19):4595-602 [8402633] Lancet. 1995 Jan 28;345(8944):229-34 [7823718] Cancer Chemother Pharmacol. 1995;36(4):293-8 [7628048] Invest New Drugs. 1995;13(2):157-62 [8617579] Br J Obstet Gynaecol. 1996 Nov;103(11):1078-84 [8916992] J Pharm Pharmacol. 1996 Nov;48(11):1128-32 [8961159] Pediatrics. 1997 Jan;99(1):88-92 [8989344] Anticancer Drugs. 1997 Feb;8(2):125-40 [9073309] Indian J Physiol Pharmacol. 1997 Apr;41(2):171-5 [9142565] Br J Radiol. 1997 Jun;70(834):599-602 [9227253] Anticancer Drugs. 1998 Jun;9(5):437-48 [9660542] Methods Enzymol. 1998;292:504-14 [9711578] Cancer Res. 1998 Dec 1;58(23):5337-9 [9850061] Indian J Exp Biol. 1998 Sep;36(9):891-5 [9854429] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15665-70 [9861027] J Natl Cancer Inst. 1999 Mar 3;91(5):429-33 [10070941] Nat Med. 2005 Feb;11(2):127-9 [15685169] Int J Oncol. 2005 Mar;26(3):713-20 [15703828] J Biol Chem. 2006 Jun 23;281(25):17023-33 [16624823] J Pharmacol Exp Ther. 2006 Aug;318(2):484-94 [16632641] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Biochem Pharmacol. 2006 Sep 14;72(6):671-80 [16828058] J Urol. 2006 Oct;176(4 Pt 1):1642-7 [16952707] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Mol Cancer Ther. 2006 Dec;5(12):3209-21 [17172425] Int J Oncol. 2000 Aug;17(2):323-8 [10891542] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter. AN - 69076736; 18089722 AB - Multidrug resistance due to reduced drug accumulation is a phenomenon predominantly caused by the overexpression of members of the ATP-binding cassette (ABC) transporters, including ABCB1 (P-glycoprotein), ABCG2, and several ABCC family members [multidrug resistance-associated protein (MRP)]. We previously reported that a thiosemicarbazone derivative, NSC73306, is cytotoxic to carcinoma cells that overexpress functional P-glycoprotein, and it resensitizes these cells to chemotherapeutics. In this study, we investigated the effect of NSC73306 on cells overexpressing other ABC drug transporters, including ABCG2, MRP1, MRP4, and MRP5. Our findings showed that NSC73306 is not more toxic to cells that overexpress these transporters compared with their respective parental cells, and these transporters do not confer resistance to NSC73306 either. In spite of this, we observed that NSC73306 is a transport substrate for ABCG2 that can effectively inhibit ABCG2-mediated drug transport and reverse resistance to both mitoxantrone and topotecan in ABCG2-expressing cells. Interactions between NSC73306 and the ABCG2 drug-binding site(s) were confirmed by its stimulatory effect on ATPase activity (140-150 nmol/L concentration required for 50% stimulation) and by inhibition of [(125)I]iodoarylazidoprazosin photolabeling (50% inhibition at 250-400 nmol/L) of the substrate-binding site(s). Overall, NSC73306 seems to be a potent modulator of ABCG2 that does not interact with MRP1, MRP4, or MRP5. Collectively, these data suggest that NSC73306 can potentially be used, due to its dual mode of action, as an effective agent to overcome drug resistance by eliminating P-glycoprotein-overexpressing cells and by acting as a potent modulator that resensitizes ABCG2-expressing cancer cells to chemotherapeutics. JF - Molecular cancer therapeutics AU - Wu, Chung-Pu AU - Shukla, Suneet AU - Calcagno, Anna Maria AU - Hall, Matthew D AU - Gottesman, Michael M AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4256, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3287 EP - 3296 VL - 6 IS - 12 Pt 1 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Indoles KW - NSC73306 KW - Neoplasm Proteins KW - Photoaffinity Labels KW - Mitoxantrone KW - BZ114NVM5P KW - Index Medicus KW - Blotting, Western KW - Humans KW - Mitoxantrone -- pharmacokinetics KW - Cell Line, Tumor KW - ATP-Binding Cassette Transporters -- metabolism KW - Indoles -- metabolism KW - Indoles -- pharmacology KW - Neoplasm Proteins -- metabolism KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Evidence+for+dual+mode+of+action+of+a+thiosemicarbazone%2C+NSC73306%3A+a+potent+substrate+of+the+multidrug+resistance+linked+ABCG2+transporter.&rft.au=Wu%2C+Chung-Pu%3BShukla%2C+Suneet%3BCalcagno%2C+Anna+Maria%3BHall%2C+Matthew+D%3BGottesman%2C+Michael+M%3BAmbudkar%2C+Suresh+V&rft.aulast=Wu&rft.aufirst=Chung-Pu&rft.date=2007-12-01&rft.volume=6&rft.issue=12+Pt+1&rft.spage=3287&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-19 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Pharmacol Sci. 2006 Jan;27(1):10-6 [16337280] FEBS J. 2005 Sep;272(18):4725-40 [16156793] Cancer Res. 2006 May 1;66(9):4808-15 [16651436] Physiol Rev. 2006 Jul;86(3):849-99 [16816140] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Mol Cancer Ther. 2006 Aug;5(8):1995-2006 [16928820] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6 [17003122] Br J Pharmacol. 2006 Nov;149(5):506-15 [16981002] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] Cancer Res. 2007 May 1;67(9):4373-81 [17483351] J Exp Ther Oncol. 2004 Apr;4(1):25-35 [15255290] Cancer Res. 2000 May 15;60(10):2589-93 [10825126] Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81 [10840050] J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6 [11036110] Cancer Res. 2000 Oct 15;60(20):5761-6 [11059771] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Biochim Biophys Acta. 2001 Jun 6;1512(2):171-82 [11406094] Cancer Res. 2001 Sep 15;61(18):6635-9 [11559526] Clin Cancer Res. 2002 Jan;8(1):22-8 [11801536] J Bioenerg Biomembr. 2001 Dec;33(6):453-8 [11804186] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Annu Rev Biochem. 2002;71:537-92 [12045106] Biochemistry. 2002 Aug 6;41(31):10123-32 [12146977] Mol Pharmacol. 2002 Dec;62(6):1321-31 [12435799] Biochemistry. 2002 Nov 26;41(47):13989-4000 [12437356] Cancer Res. 2003 Jul 15;63(14):4048-54 [12874005] Int J Cancer. 2003 Dec 10;107(5):757-63 [14566825] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Cancer Res. 2004 Feb 15;64(4):1242-6 [14973080] Mini Rev Med Chem. 2004 Jan;4(1):31-9 [14754441] J Pharmacol Exp Ther. 2004 Aug;310(2):836-42 [15075385] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Clin Colorectal Cancer. 2004 Sep;4(3):163-80 [15377400] Cancer Res. 1981 May;41(5):1967-72 [7214365] J Biol Chem. 1990 Jun 15;265(17):10073-80 [1972154] Pharmazie. 1993 Sep;48(9):659-66 [8234398] J Natl Cancer Inst. 1994 Jan 19;86(2):110-7 [7903701] Cancer Res. 1994 Jan 15;54(2):357-61 [8275468] Curr Opin Genet Dev. 1996 Oct;6(5):610-7 [8939727] Biol Pharm Bull. 1996 Nov;19(11):1518-20 [8951178] J Biol Chem. 1997 Aug 22;272(34):21160-6 [9261121] Methods Enzymol. 1998;292:504-14 [9711578] Cancer Res. 1999 Jan 1;59(1):8-13 [9892175] Cancer Res. 1999 Sep 15;59(18):4559-63 [10493507] J Biol Chem. 2004 Nov 19;279(47):48855-64 [15364914] Biochim Biophys Acta. 2005 Feb 1;1668(1):53-63 [15670731] J Cell Sci. 2005 Apr 1;118(Pt 7):1417-26 [15769853] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The relationship of silicone breast implants and cancer at other sites. AN - 69076487; 18090818 AB - Although most attention regarding the effects of silicone breast implants on cancer risk has focused on breast cancer, there have also been concerns regarding effects on other cancers. This includes malignancies that could occur as a result of foreign-body carcinogenesis (sarcomas) or immune alterations (hematopoietic malignancies), or cancers suggested as possibly elevated on the basis of previous epidemiologic studies (cancers of the cervix, vulva, lung, and brain). Searches of the English language literature on the topic of silicone breast implants and cancer risk were conducted and reviewed to determine relationships that might have etiologic relevance. Epidemiologic studies provide no support for an increased risk of either sarcoma or multiple myeloma among breast implant recipients, disputing clinical and laboratory findings suggesting such a link. Although a number of epidemiologic studies have demonstrated elevated risks of cervical, vulvar, and lung cancers among breast implant patients, it is likely that these excesses relate more to lifestyle characteristics (e.g., cigarette smoking, sexual behavior) than to the effects of the implants. Brain cancer excesses, suggested in one study, have not been confirmed in either an update of the mortality experience in this study or on the basis of other investigations. At present, there is no convincing evidence that breast implants alter the risk of nonbreast malignancies. Breast implant patients should continue to be monitored for longer term risks and to assess whether cancer risk is influenced by various patient and implant characteristics. JF - Plastic and reconstructive surgery AU - Brinton, Louise A AD - Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Md. 20852-7234, USA. brinton@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 94S EP - 102S VL - 120 IS - 7 Suppl 1 KW - Silicone Gels KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Female KW - Neoplasms -- epidemiology KW - Breast Implants -- statistics & numerical data KW - Hematologic Neoplasms -- epidemiology KW - Sarcoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+and+reconstructive+surgery&rft.atitle=The+relationship+of+silicone+breast+implants+and+cancer+at+other+sites.&rft.au=Brinton%2C+Louise+A&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2007-12-01&rft.volume=120&rft.issue=7+Suppl+1&rft.spage=94S&rft.isbn=&rft.btitle=&rft.title=Plastic+and+reconstructive+surgery&rft.issn=1529-4242&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-17 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bilateral ptosis and supranuclear downgaze paralysis. AN - 69073005; 18094864 AB - The purpose of this article is to highlight an uncommon combination of supranuclear downward gaze paralysis with bilateral eyelid ptosis in a 53-year-old man with a radiation induced midbrain tumor and to discuss the aspects regarding the centers and pathways that mediate supranuclear vertical gaze movements. JF - Arquivos de neuro-psiquiatria AU - Maranhão-Filho, Péricles AU - Campos, João Carlos S AU - Lima, Marco A AD - Department of Neurosurgery, Brazilian National Cancer Institute, Avenida Canal de Marapendi 1680, Rio de Janeiro, RJ, Brazil. pmaranhaofilho@gmail.com Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1007 EP - 1009 VL - 65 IS - 4A SN - 0004-282X, 0004-282X KW - Index Medicus KW - Magnetic Resonance Imaging KW - Fatal Outcome KW - Humans KW - Aged KW - Middle Aged KW - Ophthalmoplegia -- etiology KW - Male KW - Female KW - Neoplasms, Radiation-Induced -- complications KW - Astrocytoma -- complications KW - Brain Neoplasms -- complications KW - Blepharoptosis -- etiology KW - Astrocytoma -- diagnosis KW - Brain Neoplasms -- diagnosis KW - Neoplasms, Radiation-Induced -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69073005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Drug-drug+interactions+affected+by+the+transporter+protein%2C+P-glycoprotein+%28ABCB1%2C+MDR1%29&rft.au=Aszalos%2C+A&rft.aulast=Aszalos&rft.aufirst=A&rft.date=2007-10-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2007.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohort. AN - 69070615; 18086772 AB - Meat intake, particularly red meat, has been positively associated with pancreatic cancer in some epidemiologic studies. Detailed meat-cooking methods and related mutagens formed in meat cooked at high temperatures have not been evaluated prospectively as risk factors for this malignancy. We investigated the association between meat, meat-cooking methods, meat-mutagen intake, and exocrine pancreatic cancer in the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study cohort of 537,302 individuals, aged 50 to 71 years, with complete baseline dietary data (1995-1996) ascertained from a food frequency questionnaire. A meat-cooking module was completed by 332,913 individuals 6 months after baseline. During 5 years of follow-up, 836 incident pancreatic cancer cases (555 men, 281 women) were identified. Four hundred and fifty-nine cases had complete meat module data. We used Cox proportional hazard models to calculate hazard ratios (HR) and 95% confidence intervals (CI). Total, red, and high-temperature cooked meat intake was positively associated with pancreatic cancer among men (fifth versus first quintile: HR, 1.41, 95% CI, 1.08-1.83, P trend = 0.001; HR, 1.42, 95% CI, 1.05-1.91, P trend = 0.01; and HR, 1.52, 95% CI, 1.12-2.06, P trend = 0.005, respectively), but not women. Men showed significant 50% increased risks for the highest tertile of grilled/barbecued and broiled meat and significant doubling of risk for the highest quintile of overall meat-mutagenic activity (P trends < 0.01). The fifth quintile of the heterocyclic amine, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline intake showed a significant 29% (P trend = 0.006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Stolzenberg-Solomon, Rachael Z AU - Cross, Amanda J AU - Silverman, Debra T AU - Schairer, Catherine AU - Thompson, Frances E AU - Kipnis, Victor AU - Subar, Amy F AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - National Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health Human Services, Rockville, MD 20852, USA. rs221z@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2664 EP - 2675 VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Mutagens KW - 0 KW - Index Medicus KW - United States KW - Sex Factors KW - Risk Factors KW - Humans KW - National Institutes of Health (U.S.) KW - Aged KW - Middle Aged KW - Male KW - Female KW - Meat KW - Mutagens -- adverse effects KW - Cooking -- methods KW - Diet KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69070615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Meat+and+meat-mutagen+intake+and+pancreatic+cancer+risk+in+the+NIH-AARP+cohort.&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BCross%2C+Amanda+J%3BSilverman%2C+Debra+T%3BSchairer%2C+Catherine%3BThompson%2C+Frances+E%3BKipnis%2C+Victor%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2007-12-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ovarian cancer and menopausal hormone therapy: more data and new questions. AN - 69069885; 18086754 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Lacey, James V AD - Jr., Division of Cancer Epidemiology and Genetics, National Cancer Institute, MSC 7234, 6120 Executive Boulevard, Rockville, MD 20852-7234. jimlacey@nih.gov. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2524 EP - 2525 VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Time Factors KW - Female KW - Hormone Replacement Therapy -- adverse effects KW - Ovarian Neoplasms -- chemically induced KW - Menopause UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69069885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Ovarian+cancer+and+menopausal+hormone+therapy%3A+more+data+and+new+questions.&rft.au=Lacey%2C+James+V&rft.aulast=Lacey&rft.aufirst=James&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2524&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2548-56 [18086757] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts. AN - 69069773; 17914885 AB - Furosemide (Lasix) is frequently used in the treatment of cardiovascular and renal disease. Only one metabolite, furosemide glucuronide, has ever been identified. Oxidation of furosemide by cytochrome P450 has been demonstrated, but the metabolite(s) has never been identified. The oxidation of furosemide by dimethyldioxirane in acetone and by liver microsomal incubations was explored in this study. The first observable product from dimethyldioxirane oxidation was a ring-expanded enone resulting from an intramolecular condensation of the aldehyde group of the enonal, the secondary amine, and the carboxylic acid in a Mannich-like reaction. Keto-enol tautomerization and opening of the lactone gave a stable pyridinium salt. The pyridinium salt was also observed in the microsomal incubations of furosemide. The presence of an internal nucleophile in furosemide may have a significant effect on the toxicology and possibly the pharmacology of this furan. JF - Chemical research in toxicology AU - Chen, Ling-Jen AU - Burka, Leo T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. ljferguson@lrri.org Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1741 EP - 1744 VL - 20 IS - 12 SN - 0893-228X, 0893-228X KW - Diuretics KW - 0 KW - Epoxy Compounds KW - Pyridinium Compounds KW - Salts KW - dimethyldioxirane KW - 74087-85-7 KW - Furosemide KW - 7LXU5N7ZO5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Molecular Structure KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Rats, Inbred F344 KW - Biotransformation KW - Epoxy Compounds -- chemistry KW - Male KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Diuretics -- metabolism KW - Pyridinium Compounds -- chemistry KW - Pyridinium Compounds -- metabolism KW - Diuretics -- chemistry KW - Microsomes, Liver -- enzymology KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Furosemide -- chemistry KW - Furosemide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69069773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Chemical+and+enzymatic+oxidation+of+furosemide%3A+formation+of+pyridinium+salts.&rft.au=Chen%2C+Ling-Jen%3BBurka%2C+Leo+T&rft.aulast=Chen&rft.aufirst=Ling-Jen&rft.date=2007-12-01&rft.volume=20&rft.issue=12&rft.spage=1741&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe. AN - 69061901; 17947404 AB - Currently, no transposon-based method for the mutagenesis of Schizosaccharomyces pombe exists. We have developed such a system based on the introduction of the hermes transposon from the housefly into S. pombe. This system efficiently disrupts open reading frames and allows the insertion sites to be readily identified. JF - Genetics AU - Evertts, Adam G AU - Plymire, Christopher AU - Craig, Nancy L AU - Levin, Henry L AD - Section of Eukaryotic Transposable Elements, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2519 EP - 2523 VL - 177 IS - 4 SN - 0016-6731, 0016-6731 KW - DNA Transposable Elements KW - 0 KW - Index Medicus KW - Animals KW - Open Reading Frames KW - Binding Sites KW - Schizosaccharomyces -- genetics KW - Houseflies -- genetics KW - Mutagenesis, Insertional -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=The+hermes+transposon+of+Musca+domestica+is+an+efficient+tool+for+the+mutagenesis+of+Schizosaccharomyces+pombe.&rft.au=Evertts%2C+Adam+G%3BPlymire%2C+Christopher%3BCraig%2C+Nancy+L%3BLevin%2C+Henry+L&rft.aulast=Evertts&rft.aufirst=Adam&rft.date=2007-12-01&rft.volume=177&rft.issue=4&rft.spage=2519&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1995 Jun;15(6):3310-7 [7760826] Gene. 1993 Jan 15;123(1):131-6 [8422997] Yeast. 1998 Jul;14(10):943-51 [9717240] Nature. 2004 Dec 23;432(7020):995-1001 [15616554] Genetics. 2005 Mar;169(3):1779-85 [15654093] Yeast. 2005 May;22(7):583-91 [15942936] Nature. 2005 Jul 14;436(7048):221-6 [16015321] Cytogenet Genome Res. 2005;110(1-4):566-74 [16093710] Cell. 2005 Aug 12;122(3):473-83 [16096065] Nucleic Acids Res. 1993 Jun 25;21(12):2955-6 [8332516] Nature. 1999 Nov 25;402(6760):413-8 [10586881] Nucleic Acids Res. 2000 Dec 1;28(23):4709-16 [11095681] Nature. 2002 Feb 21;415(6874):871-80 [11859360] Eukaryot Cell. 2002 Feb;1(1):44-55 [12455970] Mol Genet Genomics. 2003 Mar;268(6):779-90 [12655404] Genetics. 2004 Jun;167(2):761-81 [15238527] Mol Cell Biol. 1986 Nov;6(11):3643-51 [3540598] Science. 1996 Dec 20;274(5295):2069-74 [8953036] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gynecologic and hormonal effects of raloxifene in premenopausal women. AN - 69058943; 17662283 AB - To assess the effects of raloxifene on the ovaries, uterus, and serum hormone levels in premenopausal women. Prospective study comparing pretreatment findings with findings for those on treatment. Government research hospital. Thirty women 35 to 47 years of age who were at high risk of breast cancer and had regular, ovulatory menstrual cycles. Raloxifene (60 mg) and calcium (1,200 mg) daily for 2 years. Sonographic evidence of ovarian stimulation (>or=2 corpora lutea, or follicular cysts of >2 cm, or single follicular cyst of >3 cm). Changes in endometrial thickness, fibroid size, hormone levels, and menstrual-cycle length. Fifteen subjects developed some cycles with asymptomatic ovarian stimulation, and 9 developed benign endometrial polyps, compared with 2 subjects and 1 subject pretreatment, respectively. Uterine fibroid size was unchanged during raloxifene use in 16 subjects with fibroids. On treatment, E(2) levels increased significantly only during the follicular phase, with peak E(2) levels significantly higher in cycles showing ovarian stimulation compared with those without. Sex hormone-binding globulin increased, but levels of LH, FSH, P, DHEAS, and T did not. Endometrial thickness and cycle length were unchanged. Premenopausal subjects receiving raloxifene showed sonographic and hormonal evidence of ovarian stimulation. Endometrial thickness, cycle length, and fibroid size were unchanged. Benign asymptomatic endometrial polyps developed in some. JF - Fertility and sterility AU - Premkumar, Ahalya AU - Venzon, David J AU - Avila, Nilo AU - Johnson, Diane V AU - Remaley, Alan T AU - Forman, Michele R AU - Eng-Wong, Jennifer AU - Zujewski, JoAnne AU - Stratton, Pamela AD - Department of Diagnostic Radiology, Warren G. Magnuson Clinical Center, Bethesda, Maryland, USA. ps79c@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1637 EP - 1644 VL - 88 IS - 6 KW - Gonadal Steroid Hormones KW - 0 KW - Selective Estrogen Receptor Modulators KW - Raloxifene Hydrochloride KW - 4F86W47BR6 KW - Dehydroepiandrosterone Sulfate KW - 57B09Q7FJR KW - Calcium Carbonate KW - H0G9379FGK KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Menstrual Cycle -- blood KW - Ultrasonography KW - Selective Estrogen Receptor Modulators -- administration & dosage KW - Calcium Carbonate -- administration & dosage KW - Drug Therapy, Combination KW - Polyps -- diagnostic imaging KW - Uterine Diseases -- chemically induced KW - Selective Estrogen Receptor Modulators -- adverse effects KW - Risk Factors KW - Selective Estrogen Receptor Modulators -- therapeutic use KW - Adult KW - Dehydroepiandrosterone Sulfate -- blood KW - Middle Aged KW - Uterine Diseases -- diagnostic imaging KW - Female KW - Polyps -- chemically induced KW - Genitalia, Female -- diagnostic imaging KW - Genitalia, Female -- drug effects KW - Carcinoma -- etiology KW - Raloxifene Hydrochloride -- therapeutic use KW - Carcinoma -- prevention & control KW - Breast Neoplasms -- prevention & control KW - Breast Neoplasms -- etiology KW - Raloxifene Hydrochloride -- administration & dosage KW - Raloxifene Hydrochloride -- adverse effects KW - Premenopause -- drug effects KW - Gonadal Steroid Hormones -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69058943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Salmonella+enterica+Serovar+Typhi+Ty21a+Expressing+Human+Papillomavirus+Type+16+L1+as+a+Potential+Live+Vaccine+against+Cervical+Cancer+and+Typhoid+Fever&rft.au=Fraillery%2C+Dominique%3BBaud%2C+David%3BPang%2C+Susana+Yuk-Ying%3BSchiller%2C+John%3BBobst%2C+Martine%3BZosso%2C+Nathalie%3BPonci%2C+Francoise%3BNardelli-Haefliger%2C+Denise&rft.aulast=Fraillery&rft.aufirst=Dominique&rft.date=2007-10-01&rft.volume=14&rft.issue=10&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. AN - 69050327; 17640750 AB - Cyclooxygenase-2 (COX-2) is an isoform of prostaglandin H synthase induced by hypoxia and has been implicated in the growth and progression of a variety of human cancers. In the present study, we investigated the role of phospholipase D (PLD) isozymes in cobalt chloride (CoCl(2))-induced hypoxia-driven COX-2 expression in U87 MG human astroglioma cells. CoCl(2) stimulated PLD activity and synthesis of COX-2 protein in a dose and time-dependent manner. Moreover, elevated expression of PLD1 and PLD2 increased hypoxia-induced COX-2 expression and prostaglandin E2 (PGE(2)) production. Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed CoCl(2)-induced COX-2 expression and PGE(2) formation. In addition, evidence that PLD activity was involved in the stimulation of COX-2 expression was provided by the observations that overexpression of wild type PLD isozymes, but not catalytically inactive PLD isozymes, stimulated CoCl(2)-induced COX-2 expression and PGE(2) production. PLD1 enhanced COX-2 expression by CoCl(2) via reactive oxygen species (ROS), p38 MAPK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhanced CoCl(2)-induced COX-2 expression via ROS and p38 MAPK, but not ERK, PKC-delta, and PKA. Differential regulation of COX-2 expression mediated through PLD isozymes was comparable with that of CoCl(2)-induced PLD activity in these two PLD isozymes. Taken together, our results demonstrate for the first time that PLD1 and PLD2 isozymes enhance CoCl(2)-induced COX-2 expression through differential signaling pathways in astroglioma cells. JF - Biochimica et biophysica acta AU - Ahn, Bong-Hyun AU - Park, Mi Hee AU - Lee, Young Han AU - Kwon, Taeg Kyu AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute (NHLBI), NIH Bldg 10/CRC 5-3288 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1721 EP - 1731 VL - 1773 IS - 12 SN - 0006-3002, 0006-3002 KW - Isoenzymes KW - 0 KW - Lipopolysaccharides KW - Cobalt KW - 3G0H8C9362 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Phospholipase D KW - EC 3.1.4.4 KW - cobaltous chloride KW - EVS87XF13W KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phospholipases A2 -- metabolism KW - Dinoprostone -- biosynthesis KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Signal Transduction -- drug effects KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pertussis Toxin -- pharmacology KW - Cell Hypoxia -- drug effects KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Isoenzymes -- metabolism KW - Type C Phospholipases -- metabolism KW - Phospholipase D -- metabolism KW - Astrocytoma -- enzymology KW - Astrocytoma -- genetics KW - Cyclooxygenase 2 -- genetics KW - Up-Regulation -- drug effects KW - Cyclooxygenase 2 -- metabolism KW - Cobalt -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69050327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Up-regulation+of+cyclooxygenase-2+by+cobalt+chloride-induced+hypoxia+is+mediated+by+phospholipase+D+isozymes+in+human+astroglioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BPark%2C+Mi+Hee%3BLee%2C+Young+Han%3BKwon%2C+Taeg+Kyu%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2007-12-01&rft.volume=1773&rft.issue=12&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intraperitoneal chemotherapy: implications beyond ovarian cancer. AN - 69042411; 18063547 AB - The National Cancer Institute (NCI) announced in January 2006 the use of intraperitoneal (IP) combined with IV chemotherapy postoperatively as the preferred treatment method for advanced ovarian cancer. The announcement stimulated the need for oncology nurses to become familiar with IP chemotherapy administration and patient management guidelines. IP administration allows a high concentration of chemotherapy to come into direct contact with tumors and surrounding tissues and organs. IP chemotherapy also is administered in clinical trials and some clinical settings for other histologies, such as low-grade gastrointestinal carcinoma and appendiceal carcinoma, which tend to spread locally before invading the bloodstream. Local-regional chemotherapy potentially is an ideal treatment for local spread of those peritoneal carcinomas. Overall side effects from regional treatment are less severe than with systemic treatment. Oncology nurses can help minimize and alleviate discomfort associated with IP chemotherapy administration. This article focuses on nursing management strategies for patients receiving IP chemotherapy for ovarian cancer and other peritoneal carcinomatosis. JF - Clinical journal of oncology nursing AU - Marin, Keith AU - Oleszewski, Karen AU - Muehlbauer, Paula AD - The National Institutes of Health, Bethesda, MD. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 881 EP - 889 VL - 11 IS - 6 SN - 1092-1095, 1092-1095 KW - Nursing KW - United States KW - Drug Monitoring -- methods KW - Information Services KW - Infusions, Intravenous -- nursing KW - Humans KW - Clinical Trials as Topic KW - Patient Care Planning KW - Catheters, Indwelling KW - Patient Education as Topic KW - National Cancer Institute (U.S.) KW - Drug Monitoring -- nursing KW - Practice Guidelines as Topic KW - Female KW - Internet KW - Peritoneal Dialysis -- instrumentation KW - Infusions, Parenteral -- methods KW - Ovarian Neoplasms -- nursing KW - Oncology Nursing -- organization & administration KW - Nurse's Role KW - Infusions, Parenteral -- nursing KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Infusions, Parenteral -- adverse effects KW - Ovarian Neoplasms -- drug therapy KW - Oncology Nursing -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69042411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+oncology+nursing&rft.atitle=Intraperitoneal+chemotherapy%3A+implications+beyond+ovarian+cancer.&rft.au=Marin%2C+Keith%3BOleszewski%2C+Karen%3BMuehlbauer%2C+Paula&rft.aulast=Marin&rft.aufirst=Keith&rft.date=2007-12-01&rft.volume=28&rft.issue=10&rft.spage=2244&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. AN - 69036141; 17660507 AB - Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B-signaling pathway has been associated with multiple human cancers, including thyroid cancer. Recently, we showed that, similar to human thyroid cancer, the PI3K-AKT pathway is overactivated in both the thyroid and metastatic lesions of a mouse model of follicular thyroid carcinoma (TRbeta(PV/PV) mice). This TRbeta(PV/PV) mouse harbors a knockin mutant thyroid hormone receptor beta gene (TRbetaPV mutant) that spontaneously develops thyroid cancer and distant metastasis similar to human follicular thyroid cancer. That the activation of the PI3K-AKT signaling contributes to thyroid carcinogenesis raised the possibility that this pathway could be a potential therapeutic target in follicular thyroid carcinoma. The present study tested this possibility by treating TRbeta(PV/PV) mice with LY294002 (LY), a potent and specific PI3K inhibitor, and evaluating the effect of LY on the spontaneous development of thyroid cancer. LY treatment inhibited the AKT-mammalian target of rapamycin (mTOR)-p70(S6K) signaling, and it decreased cyclin D1 and increased p27(Kip1) expression to inhibit thyroid tumor growth and reduce tumor cell proliferation. LY treatment increased caspase 3 and decreased phosphorylated-BAD to induce apoptosis. In addition, LY treatment reduced the AKT-matrix metalloproteinase 2 signaling to decrease cell motility to block metastatic spread of thyroid tumors. Thus, these altered signaling pathways converged effectively to prolong survival of TRbeta(PV/PV) mice treated with LY. No significant adverse effects were observed for wild-type mice treated similarly with LY. The present study provides the first preclinical evidence for the in vivo efficacy for LY in the treatment of follicular thyroid cancer. JF - Carcinogenesis AU - Furuya, Fumihiko AU - Lu, Changxue AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2451 EP - 2458 VL - 28 IS - 12 KW - Cdkn1b protein, mouse KW - 0 KW - Chromones KW - Morpholines KW - Thyroid Hormone Receptors beta KW - Cyclin D1 KW - 136601-57-5 KW - Cyclin-Dependent Kinase Inhibitor p27 KW - 147604-94-2 KW - 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one KW - 31M2U1DVID KW - Protein Kinases KW - EC 2.7.- KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - mTOR protein, mouse KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Neoplasm Invasiveness KW - Animals KW - Apoptosis KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- drug therapy KW - Mice KW - Cyclin-Dependent Kinase Inhibitor p27 -- metabolism KW - Matrix Metalloproteinase 2 -- metabolism KW - Protein Kinases -- metabolism KW - Mice, Mutant Strains KW - Cyclin D1 -- metabolism KW - Tumor Cells, Cultured KW - Cell Movement -- drug effects KW - Signal Transduction KW - Caspase 3 -- metabolism KW - Adenocarcinoma, Follicular -- secondary KW - Thyroid Neoplasms -- metabolism KW - Morpholines -- pharmacology KW - Adenocarcinoma, Follicular -- drug therapy KW - Thyroid Hormone Receptors beta -- metabolism KW - Chromones -- pharmacology KW - Adenocarcinoma, Follicular -- metabolism KW - Morpholines -- therapeutic use KW - Thyroid Neoplasms -- drug therapy KW - Thyroid Neoplasms -- pathology KW - Thyroid Hormone Receptors beta -- genetics KW - Chromones -- therapeutic use KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69036141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+phosphatidylinositol+3-kinase+delays+tumor+progression+and+blocks+metastatic+spread+in+a+mouse+model+of+thyroid+cancer.&rft.au=Furuya%2C+Fumihiko%3BLu%2C+Changxue%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-Yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2451&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. AN - 69033512; 17768178 AB - Data from epidemiologic and twin studies suggest an important role of genetic susceptibility in prostate cancer. Variants of the macrophage scavenger receptor 1 (MSR1) gene have been linked to both hereditary and sporadic prostate cancer, although the evidence is inconclusive. Most studies have been conducted on Caucasians. The role of MSR1 in prostate cancer development among Asians, for whom rates of prostate cancer are low but rising rapidly, is unclear. To evaluate further the relationship between MSR1 variants and prostate cancer risk, we sequenced all the 11 MSR1 exons, exon-intron junctions, promoter regions, as well as 5' and 3' untranslated regions (UTRs) in 86 individuals from Shanghai, China. We identified a total of 21 sequence variants, including three novel variants that have not been reported previously. To balance genotyping cost and the capacity to capture sufficient genetic variation, we genotyped four haplotype-tagging variants (P275A, INDEL7, P346P and 3' UTR 70006), which capture 85% of the genetic variation in MSR1 in this population. These four variants, plus two other variants (PRO3 and INDEL1) that have been linked to prostate cancer risk in the previous studies, were typed for all study subjects, which included 130 prostate cancer cases, 130 patients with benign prostatic hyperplasia and 150 controls randomly selected from the population. Three of the six variants were associated with prostate cancer. Men with a P346P (a novel variant) G allele (AG + GG) had a significantly reduced risk of total prostate cancer [odds ratio = 0.47, 95% confidence interval (CI) 0.23-0.96], whereas those with a P275A G allele had a 37% reduced risk of prostate cancer (95% CI 0.39-1.02), with more pronounced reduction in risk seen for localized cancer cases (odds ratio = 0.25, 95% CI 0.12-0.52; P = 0.001). In addition, men with the INDEL7 variant had a 67% reduced risk of localized cancer (95% CI 0.16-0.68). Based on the four tagging variants, we inferred four major haplotypes that accounted for >90% of the haplotype variation in this population. The haplotype frequencies were significantly different between localized prostate cancer cases and controls, with a global P value of 0.004, and the haplotype containing the minor alleles of the P275A and INDEL7 variants was associated with a significantly reduced risk of localized prostate cancer (odds ratio = 0.28, 95% CI 0.13-0.59), relative to the most common haplotype. These results, although modest and confined mainly to localized prostate cancer, suggest that MSR1 polymorphisms may play a role in prostate cancer etiology in Chinese men. The role of MSR1 warrants further investigation in larger studies and other populations. JF - Carcinogenesis AU - Hsing, Ann W AU - Sakoda, Lori C AU - Chen, Jinbo AU - Chokkalingam, Anand P AU - Sesterhenn, Isabel AU - Gao, Yu-Tang AU - Xu, Jianfeng AU - Zheng, S Lilly AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. hsinga@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2530 EP - 2536 VL - 28 IS - 12 KW - 3' Untranslated Regions KW - 0 KW - 5' Untranslated Regions KW - MSR1 protein, human KW - Scavenger Receptors, Class A KW - Index Medicus KW - Promoter Regions, Genetic KW - Exons KW - Humans KW - Introns KW - Case-Control Studies KW - Aged KW - Male KW - China KW - Asian Continental Ancestry Group KW - Scavenger Receptors, Class A -- genetics KW - Scavenger Receptors, Class A -- physiology KW - Polymorphism, Genetic KW - Prostatic Neoplasms -- ethnology KW - Prostatic Neoplasms -- genetics KW - Prostatic Hyperplasia -- genetics KW - Genetic Predisposition to Disease KW - Prostatic Hyperplasia -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=MSR1+variants+and+the+risks+of+prostate+cancer+and+benign+prostatic+hyperplasia%3A+a+population-based+study+in+China.&rft.au=Hsing%2C+Ann+W%3BSakoda%2C+Lori+C%3BChen%2C+Jinbo%3BChokkalingam%2C+Anand+P%3BSesterhenn%2C+Isabel%3BGao%2C+Yu-Tang%3BXu%2C+Jianfeng%3BZheng%2C+S+Lilly&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormones. AN - 69033073; 17720234 AB - Data suggest that post-menopausal women with larger ovaries are at increased risk for endometrial carcinoma; however, analyses comparing ovarian volume to serum hormone levels are limited. Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study. Data for established risk and protective factors for endometrial carcinoma were collected via in-person interviews. Ovarian volumes were estimated from pathology reports. Associations between exposures and age-adjusted ovarian volumes were analyzed for 175 cases with available data. For a subset of 135 cases, we analyzed relationships between ovarian volume, adjusted for age and body mass index (BMI), and serum hormone levels by analysis of variance. Ovarian volume declined progressively from 1.83 cm3 among women ages 55-59 years to 1.23 cm3 among women age 70 years or older (p-trend=0.02). Larger ovarian volume was associated with early menarche (p-trend=0.03), having given birth (p=0.01), and weakly with elevated BMI (p-trend=0.06). After adjustment, increased ovarian volume was associated with higher estradiol (p-trend=0.007); albumin-bound estradiol (p-trend=0.01); and free estradiol (p-trend=0.006) levels; androstenedione, estrone and estrone sulfate showed similar, though non-significant associations. Among women with endometrial carcinoma, larger ovaries were associated with higher serum levels of estrogens. Further studies examining the role of the ovaries in post-menopausal hormonal carcinogenesis are warranted. JF - Gynecologic oncology AU - Sherman, Mark E AU - Madigan, M Patricia AU - Lacey, James V AU - Garcia-Closas, Montserrat AU - Potischman, Nancy AU - Carreon, Joseph D AU - Hartge, Patricia AU - Brinton, Louise A AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852-7234, USA. shermanm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 431 EP - 435 VL - 107 IS - 3 KW - Gonadal Steroid Hormones KW - 0 KW - Sex Hormone-Binding Globulin KW - Estrone KW - 2DI9HA706A KW - Androstenedione KW - 409J2J96VR KW - Estradiol KW - 4TI98Z838E KW - estrone sulfate KW - QTL48N278K KW - Index Medicus KW - Estradiol -- blood KW - Postmenopause KW - Estrone -- analogs & derivatives KW - Humans KW - Case-Control Studies KW - Sex Hormone-Binding Globulin -- metabolism KW - Aged KW - Middle Aged KW - Estrone -- blood KW - Female KW - Androstenedione -- blood KW - Ovary -- pathology KW - Endometrial Neoplasms -- pathology KW - Endometrial Neoplasms -- blood KW - Gonadal Steroid Hormones -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Ovarian+volumes+among+women+with+endometrial+carcinoma%3A+associations+with+risk+factors+and+serum+hormones.&rft.au=Sherman%2C+Mark+E%3BMadigan%2C+M+Patricia%3BLacey%2C+James+V%3BGarcia-Closas%2C+Montserrat%3BPotischman%2C+Nancy%3BCarreon%2C+Joseph+D%3BHartge%2C+Patricia%3BBrinton%2C+Louise+A&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2007-12-01&rft.volume=107&rft.issue=3&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=1095-6859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53 [15827095] Obstet Gynecol. 2005 Aug;106(2):219-26 [16055568] J Womens Health (Larchmt). 2005 Oct;14(8):704-12 [16232102] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1550-4 [16896048] Menopause. 2000 Jan-Feb;7(1):53-61 [10646704] J Clin Endocrinol Metab. 2000 Feb;85(2):645-51 [10690870] Gynecol Oncol. 2000 Jun;77(3):410-2 [10831351] Eur J Endocrinol. 2001 Jul;145(1):1-9 [11415846] Obstet Gynecol. 1965 Jun;25:747-64 [14287465] Obstet Gynecol. 1963 Feb;21:175-86 [13932912] Menopause. 1998 Winter;5(4):207-10 [9872485] Maturitas. 2002 Oct 25;43(2):77-85 [12385855] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43 [12496040] Endocr Rev. 2003 Apr;24(2):152-82 [12700178] Eur J Endocrinol. 2004 Feb;150(2):161-71 [14763914] Oncogene. 2004 Aug 23;23(38):6365-78 [15322511] Endocrinol Metab Clin North Am. 2004 Dec;33(4):661-74 [15501639] Maturitas. 1986 Mar;8(1):57-65 [3702762] Am J Obstet Gynecol. 1992 Nov;167(5):1317-25 [1442985] J Natl Cancer Inst. 1996 Aug 21;88(16):1127-35 [8757192] Ann Intern Med. 1997 Jan 1;126(1):32-5 [8992921] Mod Pathol. 1997 Oct;10(10):963-8 [9346174] Cancer Causes Control. 1998 Mar;9(2):199-207 [9578297] Hum Reprod. 1998 Jun;13(6):1437-41 [9688367] Maturitas. 1998 Jun 17;29(3):239-45 [9699195] J Reprod Med. 1998 Aug;43(8 Suppl):725-33 [9750201] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. AN - 69030277; 17690114 AB - Oncogenic K-ras is one of the most common genetic alterations in human lung adenocarcinomas. In addition, inactivation of clusters of tumor suppressor genes is required to bring about classical characteristics of cancer including angiogenesis as a prelude to invasion and metastasis. Transforming growth factor-beta (TGF-beta) 1 is a tumor suppressor gene that is implicated in lung cancer progression. Although in vitro studies have shown that TGF-beta1 and Ras pathways cooperate during tumorigenesis, the biology of interaction of TGF-beta1 and Ras has not been studied in in vivo tumorigenesis. We hypothesized that inactivation of TGF-beta1 in addition to oncogeneic activation of K-ras would lead to early initiation and faster progression to lung adenocarcinoma and invasion and metastasis. Heterozygous (HT) TGF-beta1 mice were mated with latent activatable (LA) mutated K-ras mice to generate TGF-beta1(+/+), K-ras LA (wild-type (WT)/LA) and TGF-beta1(+/-), K-ras LA (HT/LA) mice. Both HT/LA and WT/LA mice developed spontaneous lung tumors, but HT/LA mice progressed to adenocarcinomas significantly earlier compared with WT/LA mice. In addition, WT/LA adenocarcinomas had significantly higher angiogenic activity compared with HT/LA adenocarcinomas. Thus, while oncogenic K-ras mutation and insensitivity to the growth regulatory effects of TGF-beta1 is essential for initiation and progression of mouse lung tumors to adenocarcinoma, a full gene dosage of TGF-beta1 is required for tumor-induced angiogenesis and invasive potential. This study identifies a number of genes not previously associated with lung cancer that are involved in tumor induction and progression. In addition, we provide evidence that progression to invasive angiogenic lesions requires TGF-beta1 responsiveness in addition to Ras mutation. JF - Carcinogenesis AU - Pandey, Jyotsna AU - Umphress, Sarah M AU - Kang, Yang AU - Angdisen, Jerry AU - Naumova, Alena AU - Mercer, Kim L AU - Jacks, Tyler AU - Jakowlew, Sonia B AD - Cell and Cancer Biology Branch, National Cancer Institute, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2589 EP - 2596 VL - 28 IS - 12 KW - Transforming Growth Factor beta1 KW - 0 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Oligonucleotide Array Sequence Analysis KW - Heterozygote KW - Mice, Inbred C57BL KW - Disease Progression KW - Mice KW - Neovascularization, Pathologic KW - Mutation KW - Adenocarcinoma -- metabolism KW - Lung Neoplasms -- blood supply KW - Genes, ras -- physiology KW - Adenocarcinoma -- blood supply KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Transforming Growth Factor beta1 -- physiology KW - Transforming Growth Factor beta1 -- genetics KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69030277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Modulation+of+tumor+induction+and+progression+of+oncogenic+K-ras-positive+tumors+in+the+presence+of+TGF-+b1+haploinsufficiency.&rft.au=Pandey%2C+Jyotsna%3BUmphress%2C+Sarah+M%3BKang%2C+Yang%3BAngdisen%2C+Jerry%3BNaumova%2C+Alena%3BMercer%2C+Kim+L%3BJacks%2C+Tyler%3BJakowlew%2C+Sonia+B&rft.aulast=Pandey&rft.aufirst=Jyotsna&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2589&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. AN - 69029469; 18006619 AB - (11)C-PBR28 ([methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine) is a recently developed radioligand to image peripheral benzodiazepine receptors (PBRs) in brain. The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein. Whole-body PBR images were acquired after intravenous bolus administration of (11)C-PBR28 in 7 healthy humans (651 +/- 111 MBq) and 2 rhesus monkeys (370 +/- 59.9 MBq). One monkey was scanned after receptor blockade with PK 11195 (10.7 mg/kg intravenously). For typical subjects (subjects 1-6), the 3 organs with highest exposure were those with the high PBR densities (kidneys, spleen, and lungs), and the effective dose was 6.6 microSv/MBq. The unusual subject (subject 7) had 60%-90% less uptake in these 3 organs, resulting in 28% lower effective dose. The activity in the baseline monkey scans was greater than that in humans for organs with high PBR densities. For this reason, the human effective dose was overestimated by 60% with monkey biodistribution data. The monkey with receptor blockade had an overall distribution qualitatively similar to that of the unusual human subject (subject 7), with decreased exposure to lungs, kidney, and spleen. The effective dose of (11)C-PBR28 was modest and was similar to that of several other (11)C-radioligands. Lack of receptor binding in the unusual human subject and in the monkey with receptor blockade decreased exposure to organs with high PBR densities and enhanced uptake in excretory and metabolic pathways. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Brown, Amira K AU - Fujita, Masahiro AU - Fujimura, Yota AU - Liow, Jeih-San AU - Stabin, Michael AU - Ryu, Yong H AU - Imaizumi, Masao AU - Hong, Jinsoo AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-2035, USA. amirabrown@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2072 EP - 2079 VL - 48 IS - 12 SN - 0161-5505, 0161-5505 KW - (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine KW - 0 KW - Carbon Radioisotopes KW - Isoquinolines KW - Pyrimidines KW - Radiopharmaceuticals KW - Receptors, GABA KW - TSPO protein, human KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Animals KW - Isoquinolines -- pharmacokinetics KW - Humans KW - Adult KW - Macaca mulatta KW - Tissue Distribution KW - Radioligand Assay KW - Species Specificity KW - Male KW - Female KW - Receptors, GABA -- analysis KW - Radiopharmaceuticals -- pharmacokinetics KW - Radiation Dosage KW - Positron-Emission Tomography -- methods KW - Pyrimidines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69029469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Prospective+investigation+of+the+cigarette+smoking-head+and+neck+cancer+association+by+sex&rft.au=Freedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BLeitzmann%2C+Michael+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-10-01&rft.volume=110&rft.issue=7&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.22930 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease. AN - 69028118; 18046720 AB - More than 70% of alcohol is consumed by 10% of the population in the United States. Implicit in this statistic is that tremendous variation in the pattern of drinking (quantity, frequency, and duration) exists among alcohol consumers. Individuals who are binge or chronic drinkers will have different health outcomes than social drinkers. Therefore, knowing the pattern of drinking will shed light on how severely individuals are alcohol-dependent and on the extent of liver damage. Thus, these parameters assume particular relevance for the treatment-providing physician. Genetic factors contribute substantially to differences in alcohol metabolism. Variations in the activities of the alcohol-metabolizing enzymes, cytosolic alcohol dehydrogenase and mitochondrial aldehyde dehydrogenase, in part determine blood alcohol concentration, thereby contributing to the predisposition to becoming alcohol-dependent and to susceptibility to alcohol-induced liver damage. Chronic alcohol consumption induces cytochrome P450 2E1, a microsomal enzyme that metabolizes alcohol at high concentrations and also metabolizes medications such as acetaminophen and protease inhibitors. Alcohol metabolism changes the redox state of the liver, which leads to alterations in hepatic lipid, carbohydrate, protein, lactate, and uric acid metabolism. The quantity and frequency of alcohol consumption severely impact the liver in the presence of comorbid conditions such as infection with hepatitis B or C and/or human immunodeficiency virus, type 2 diabetes, hemochromatosis, or obesity and thus have implications with respect to the extent of injury and response to medications. Knowledge of the relationships between the quantity, frequency, and patterns of drinking and alcoholic liver disease is limited. A better understanding of these relationships will guide hepatologists in managing alcoholic liver disease. JF - Hepatology (Baltimore, Md.) AU - Zakhari, Samir AU - Li, Ting-Kai AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. szakhari@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2032 EP - 2039 VL - 46 IS - 6 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Ethanol -- adverse effects KW - Alcohol Drinking -- adverse effects KW - Alcoholism -- complications KW - Liver Diseases, Alcoholic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69028118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Determinants+of+alcohol+use+and+abuse%3A+Impact+of+quantity+and+frequency+patterns+on+liver+disease.&rft.au=Zakhari%2C+Samir%3BLi%2C+Ting-Kai&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2007-12-01&rft.volume=46&rft.issue=6&rft.spage=2032&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. AN - 69026224; 17510980 AB - Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas interruption of two alleles (homozygous, -/-) caused fatal failure of dorsal midline brain structure formation. These mutagenesis studies implicated RFX4_v3 in early brain development as well as the genesis of the SCO. Rfx4_v3 deficiency presumably causes abnormalities in brain by altering the expression levels of many genes that are crucial for brain morphogenesis, such as the signaling components in the Wnt, bone morphogenetic protein, and retinoic acid pathways. RFX4_v3 might affect these critical signaling pathways in brain development. Cx3cl1, a chemokine gene highly expressed in brain, was identified as a direct target for RFX4_v3, indicating that RFX4_v3 possesses trans-acting activity to stimulate gene expression. Rfx4_v3 is highly expressed in the suprachiasmatic nucleus and might be involved in regulating the circadian clock. One haplotype in RFX4_v3 gene is linked to a higher risk of bipolar disorder, suggesting that this protein might contribute to the pathogenesis of the disease. This Mini-Review describes our current knowledge about RFX4_v3, an important protein that appears to be involved in many aspects of brain development and disease. (c) 2007 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Zhang, Donghui AU - Zeldin, Darryl C AU - Blackshear, Perry J AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3515 EP - 3522 VL - 85 IS - 16 SN - 0360-4012, 0360-4012 KW - DNA-Binding Proteins KW - 0 KW - Regulatory Factor X Transcription Factors KW - Rfx4 protein, mouse KW - Transcription Factors KW - Index Medicus KW - Animals KW - Hydrocephalus -- physiopathology KW - Bipolar Disorder -- physiopathology KW - Humans KW - Hydrocephalus -- metabolism KW - Signal Transduction -- genetics KW - Bipolar Disorder -- genetics KW - Bipolar Disorder -- metabolism KW - Circadian Rhythm -- genetics KW - Hydrocephalus -- genetics KW - Nervous System Malformations -- metabolism KW - Transcription Factors -- metabolism KW - Brain Diseases -- genetics KW - DNA-Binding Proteins -- genetics KW - Brain -- metabolism KW - Brain Diseases -- physiopathology KW - Transcription Factors -- genetics KW - Brain Diseases -- metabolism KW - Gene Expression Regulation, Developmental -- genetics KW - Nervous System Malformations -- genetics KW - Nervous System Malformations -- physiopathology KW - Brain -- embryology KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69026224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Regulatory+factor+X4+variant+3%3A+a+transcription+factor+involved+in+brain+development+and+disease.&rft.au=Zhang%2C+Donghui%3BZeldin%2C+Darryl+C%3BBlackshear%2C+Perry+J&rft.aulast=Zhang&rft.aufirst=Donghui&rft.date=2007-12-01&rft.volume=85&rft.issue=16&rft.spage=3515&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 Sep 12;35(6):1029-41 [12354394] Development. 2002 Dec;129(23):5487-98 [12403718] Development. 2003 May;130(10):2039-50 [12668619] Psychiatr Genet. 2003 Jun;13(2):77-84 [12782963] J Neurosci Res. 2003 Jul 1;73(1):81-8 [12815711] Development. 2003 Oct;130(19):4539-52 [12925582] J Biol Chem. 2004 Mar 12;279(11):10237-42 [14701801] Mol Cell Biol. 2004 May;24(10):4417-27 [15121860] PLoS Biol. 2004 Aug;2(8):E219 [15314648] Circ Res. 2004 Sep 3;95(5):506-14 [15256482] J Pathol. 2004 Nov;204(4):470-7 [15495266] Fed Proc. 1983 Aug;42(11):2809-14 [6873309] Mol Endocrinol. 1992 May;6(5):773-85 [1603086] Development. 1997 Jun;124(11):2203-12 [9187146] Mol Cell Biol. 1999 Jun;19(6):3940-50 [10330134] Mol Psychiatry. 2005 Oct;10(10):920-7 [15940297] Cancer Sci. 2005 Nov;96(11):801-9 [16271074] J Clin Invest. 2006 Jul;116(7):1828-32 [16823482] J Neurochem. 2006 Aug;98(3):860-75 [16893423] Eur J Neurosci. 2006 Aug;24(4):1020-30 [16930429] Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R271-7 [16987893] J Mol Biol. 1999 Nov 19;294(1):121-37 [10556033] Development. 2000 Feb;127(3):457-67 [10631167] Nature. 2000 Feb 24;403(6772):916-21 [10706293] Mol Cell. 2000 Mar;5(3):411-21 [10882127] Microsc Res Tech. 2001 Mar 1;52(5):573-90 [11241867] Annu Rev Immunol. 2001;19:331-73 [11244040] Hum Mutat. 2001;18(1):1-12 [11438988] J Biol Chem. 2002 Jan 4;277(1):836-42 [11682486] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Simultaneous determination of salsolinol enantiomers and dopamine in human plasma and cerebrospinal fluid by chemical derivatization coupled to chiral liquid chromatography/electrospray ionization-tandem mass spectrometry. AN - 68562470; 17973500 AB - A sensitive, specific, and robust method to simultaneously determine enantiomeric salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL), a potential biomarker implicated in alcohol-related neurotoxicity in a stereoselective manner, and its precursor dopamine (DA) has been developed using simple chemical derivatization and chiral separation coupled with electrospray ionization-tandem mass spectrometry (ESI-MS/MS). SAL enantiomers and DA were converted to stable pentafluorobenzyl (PFB) derivatives directly from aqueous media. Bulky PFB groups introduced into the SAL structure enabled baseline separation of SAL stereoisomers on a chiral column without cumbersome chiral derivatization to unstable SAL diastereomers. Subsequent analysis by ESI-MS/MS with multiple reaction monitoring (MRM) in the presence of deuterium-labeled internal standards allowed specific detection of both derivatives with a wide dynamic range (SAL, 0.5-5000 pg; DA, 0.02-20 ng). The limit of quantitation assayed in the plasma matrix was below 10 pg for each SAL enantiomer and 100 pg for DA. Both coefficient of variance and error for inter- and intraday measurements in the blank plasma were less than 10% for SAL and DA in the concentration range of 10-4000 pg/mL and 0.1-8 ng/mL, respectively. This strategy enabled routine and specific determination of both SAL enantiomers and DA from 0.5 mL of human plasma and cerebrospinal fluid, which has not been possible using existing methodologies. JF - Analytical chemistry AU - Lee, Jeongrim AU - Huang, Bill X AU - Yuan, Zhixin AU - Kim, Hee-Yong AD - Laboratory of Molecular Signaling, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9410, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 9166 EP - 9173 VL - 79 IS - 23 SN - 0003-2700, 0003-2700 KW - Isoquinolines KW - 0 KW - salsolinol KW - 9ILS801M65 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Sensitivity and Specificity KW - Stereoisomerism KW - Humans KW - Isoquinolines -- blood KW - Isoquinolines -- cerebrospinal fluid KW - Tandem Mass Spectrometry -- methods KW - Dopamine -- analysis KW - Dopamine -- blood KW - Isoquinolines -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Dopamine -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68562470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Simultaneous+determination+of+salsolinol+enantiomers+and+dopamine+in+human+plasma+and+cerebrospinal+fluid+by+chemical+derivatization+coupled+to+chiral+liquid+chromatography%2Felectrospray+ionization-tandem+mass+spectrometry.&rft.au=Iyer%2C+Lakshminarayan+M%3BAnantharaman%2C+Vivek%3BAravind%2C+L&rft.aulast=Iyer&rft.aufirst=Lakshminarayan&rft.date=2007-10-01&rft.volume=23&rft.issue=20&rft.spage=2660&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-28 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - RNA polymerase is poised for activation across the genome. AN - 68559308; 17994021 AB - Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of genes. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto-oncogenes, whose expression is attenuated by regulated stalling of polymerase elongation within the promoter-proximal region. To determine the importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for Drosophila melanogaster genes with Pol II stalled within the promoter-proximal region. Our data show that stalling is widespread, occurring at hundreds of genes that respond to stimuli and developmental signals. This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues. JF - Nature genetics AU - Muse, Ginger W AU - Gilchrist, Daniel A AU - Nechaev, Sergei AU - Shah, Ruchir AU - Parker, Joel S AU - Grissom, Sherry F AU - Zeitlinger, Julia AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1507 EP - 1511 VL - 39 IS - 12 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Drosophila melanogaster KW - Chromatin Immunoprecipitation KW - Transcriptional Activation KW - RNA Polymerase II -- metabolism KW - Genome, Insect KW - Transcription, Genetic KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68559308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Inhibition+of+lipid+peroxidation+and+enhancement+of+GST+activity+by+cardamom+and+cinnamon+during+chemically+induced+colon+carcinogenesis+in+Swiss+albino+mice.&rft.au=Bhattacharjee%2C+Shamee%3BRana%2C+Tapasi%3BSengupta%2C+Archana&rft.aulast=Bhattacharjee&rft.aufirst=Shamee&rft.date=2007-10-01&rft.volume=8&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-11 N1 - Date created - 2007-11-29 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE6714; GEO N1 - SuppNotes - Cited By: Cell. 1988 Sep 9;54(6):795-804 [3136931] Mol Cell Biol. 1986 Nov;6(11):3984-9 [3099167] Genes Dev. 1992 Nov;6(11):2201-13 [1427080] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7923-7 [8367444] Genes Dev. 1995 Mar 1;9(5):559-72 [7698646] J Mol Biol. 1995 Oct 6;252(5):522-35 [7563071] Nucleic Acids Res. 1998 Feb 15;26(4):919-24 [9461448] J Virol. 1998 Sep;72(9):7154-9 [9696809] Cold Spring Harb Symp Quant Biol. 1998;63:289-300 [10384293] Cold Spring Harb Symp Quant Biol. 1998;63:347-56 [10384299] J Immunol. 1999 Oct 15;163(8):4375-82 [10510378] Mol Cell. 2005 Jan 7;17(1):103-12 [15629721] FEBS Lett. 2005 Feb 7;579(4):909-15 [15680973] Nature. 2005 Aug 11;436(7052):876-80 [15988478] Cell. 2005 Aug 26;122(4):517-27 [16122420] Cell. 2006 Apr 21;125(2):301-13 [16630818] Mol Cell Biol. 2006 Aug;26(16):6094-104 [16880520] Nat Biotechnol. 2006 Aug;24(8):963-70 [16900145] Nat Rev Mol Cell Biol. 2006 Aug;7(8):557-67 [16936696] Genes Dev. 2007 May 1;21(9):1031-6 [17473169] EMBO J. 1992 Sep;11(9):3307-14 [1505520] Mol Cell Biol. 1990 Nov;10(11):6041-5 [2172790] Mol Cell Biol. 2002 May;22(9):2918-27 [11940650] Curr Biol. 2003 Feb 18;13(4):350-7 [12593803] Mol Cell Biol. 2003 Mar;23(6):1863-73 [12612062] Genes Dev. 2003 Jun 1;17(11):1402-14 [12782658] Annu Rev Biochem. 2003;72:693-715 [12676794] Mol Cell Biol. 2003 Nov;23(21):7628-37 [14560008] Genes Dev. 2004 Sep 1;18(17):2134-46 [15342491] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] Comment In: Nat Genet. 2007 Dec;39(12):1421-2 [18046324] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. AN - 68549019; 17200667 AB - To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5' region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P100-fold. Humanized immunoglobulin G (IgG) 5H2, originally produced from an expression vector, has been shown to be a variant containing a nine-amino-acid deletion in the Fc region which completely ablates antibody-dependent enhancement of DENV replication in vitro. The variant MAb, termed IgG 5H2 deltaD, is particularly attractive for exploring its protective capacity in vivo. Passive transfer of IgG 5H2 deltaD at 20 microg/mouse afforded 50% protection of suckling mice against challenge with 25 50% lethal doses of mouse neurovirulent DENV-4 strain H241. Passive transfer of antibody to monkeys was conducted to demonstrate proof of concept for protection against DENV challenge. Monkeys that received 2 mg/kg of body weight of IgG 5H2 deltaD were completely protected against 100 50% monkey infectious doses (MID50) of DENV-4, as indicated by the absence of viremia and seroconversion. A DENV-4 escape mutant that contained a Lys174-Glu substitution identical to that found in vitro was isolated from monkeys challenged with 10(6) MID50 of DENV-4. This substitution was also present in all naturally occurring isolates belonging to DENV-4 genotype III. These studies have important implications for possible antibody-mediated prevention of DENV infection. JF - Journal of virology AU - Lai, Ching-Juh AU - Goncalvez, Ana P AU - Men, Ruhe AU - Wernly, Claire AU - Donau, Olivia AU - Engle, Ronald E AU - Purcell, Robert H AD - Laboratory of Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8005, Bethesda, MD 20892, USA. clai@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 12766 EP - 12774 VL - 81 IS - 23 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Viral KW - Antigens, Viral KW - Epitopes KW - Index Medicus KW - Animals KW - Amino Acid Substitution -- genetics KW - DNA Mutational Analysis KW - Neutralization Tests KW - Lethal Dose 50 KW - Mice KW - Macaca mulatta KW - Mice, Inbred BALB C KW - Immunization, Passive -- methods KW - Epitope Mapping KW - Survival Analysis KW - Antibodies, Viral -- therapeutic use KW - Antibodies, Viral -- genetics KW - Antibodies, Monoclonal -- genetics KW - Antigens, Viral -- immunology KW - Dengue Virus -- immunology KW - Epitopes -- immunology KW - Antibodies, Viral -- immunology KW - Dengue -- prevention & control KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68494649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2007-10-01&rft.volume=197&rft.issue=4&rft.spage=356.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1991 Jun;72 ( Pt 6):1323-9 [1710648] Am J Trop Med Hyg. 1990 Aug;43(2):212-8 [1975159] J Virol. 1993 Nov;67(11):6567-75 [8411360] Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2395-400 [8146129] Nature. 1995 May 25;375(6529):291-8 [7753193] J Gen Virol. 1997 Jan;78 ( Pt 1):31-7 [9010282] J Gen Virol. 1997 Sep;78 ( Pt 9):2279-84 [9292015] Electrophoresis. 1997 Dec;18(15):2714-23 [9504803] Virology. 1998 Jul 5;246(2):317-28 [9657950] Am J Trop Med Hyg. 1952 Jan;1(1):30-50 [14903434] Am J Trop Med Hyg. 1952 Jan;1(1):66-77 [14903437] Am J Trop Med Hyg. 1958 Sep;7(5):561-73 [13571577] J Virol. 2004 Dec;78(23):12910-8 [15542643] J Virol. 2004 Dec;78(23):12919-28 [15542644] J Virol. 2005 Jan;79(2):1223-31 [15613349] J Infect Dis. 2005 Mar 1;191(5):710-8 [15688284] Nature. 2005 Sep 29;437(7059):764-9 [16193056] J Virol. 2006 Jul;80(14):6982-92 [16809304] J Virol. 2006 Oct;80(19):9557-68 [16973559] Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7 [17517625] J Virol. 2007 Nov;81(21):11828-39 [17715236] Cell Host Microbe. 2007 Apr 19;1(2):135-45 [18005691] J Virol. 2001 Aug;75(16):7769-73 [11462053] J Clin Microbiol. 2001 Dec;39(12):4506-13 [11724870] Arch Virol. 2001 Dec;146(12):2469-79 [11811694] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91 [12759475] Mol Biol Evol. 2003 Oct;20(10):1650-8 [12832629] J Virol. 2004 Jan;78(1):378-88 [14671119] Adv Virus Res. 2003;59:315-41 [14696333] Nature. 2004 Jan 22;427(6972):313-9 [14737159] Am J Trop Med Hyg. 2003 Dec;69(6 Suppl):5-11 [14740949] EMBO J. 2004 Feb 25;23(4):728-38 [14963486] J Virol. 2004 May;78(9):4665-74 [15078949] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Vaccine. 2004 Sep 9;22(27-28):3722-6 [15315852] Virology. 2004 Nov 10;329(1):168-79 [15476884] Yale J Biol Med. 1970 Apr;42(5):350-62 [5419208] Am J Trop Med Hyg. 1976 Jan;25(1):146-50 [3980] Nature. 1977 Feb 24;265(5596):739-41 [404559] J Infect Dis. 1979 Oct;140(4):527-33 [117061] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Am J Epidemiol. 1984 Nov;120(5):653-69 [6496446] Trans R Soc Trop Med Hyg. 1985;79(2):248-51 [2860743] Arch Virol. 1985;86(1-2):129-35 [4038069] J Gen Virol. 1986 Feb;67 ( Pt 2):229-34 [3944585] Am J Trop Med Hyg. 1986 Mar;35(2):393-400 [3513650] Adv Virus Res. 1986;31:103-68 [2428213] J Virol. 1986 Dec;60(3):1153-5 [3783816] Am J Trop Med Hyg. 1987 Mar;36(2):427-34 [3826503] Bull Pan Am Health Organ. 1987;21(3):270-9 [3442718] J Immunol. 1988 Nov 15;141(10):3606-10 [2460542] J Virol. 1989 Feb;63(2):564-71 [2463377] Virology. 1989 Mar;169(1):90-9 [2466373] J Immunol. 1990 Apr 15;144(8):3183-6 [2139079] Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5139-43 [2052593] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method. AN - 68389080; 17624688 AB - Although improvement in psychosocial functioning is a common goal in substance-abuse treatment, the primary outcome measure in most cocaine trials is urinalysis-verified cocaine use. However, the relationship between cocaine use and psychosocial outcomes is not well documented. To investigate this relationship and identify the optimal urine-screen method, we retrospectively analyzed data from two 25-week randomized controlled trials of abstinence reinforcement (AR) in 368 cocaine/heroin users maintained on methadone. Cocaine use was measured thrice weekly by qualitative urinalysis, benzoylecgonine concentration (BE), and an estimate of New Uses of cocaine by application of an algorithm to BE. Social adjustment (SAS-SR), current diagnosis of cocaine dependence (DSM-IV criteria), and depression symptoms (Beck Depression Inventory) were determined at study exit. Cocaine use was significantly lower in AR groups than in controls. Across groups, in-treatment cocaine use was significantly associated with worse social adjustment, current cocaine dependence, and depression at exit. Significant differences were detected more frequently with New Uses than qualitative urinalysis or BE. Nevertheless, the amount of variance accounted for by the urine screens was typically <15%. Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning. JF - Drug and alcohol dependence AU - Ghitza, Udi E AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. ghitzau@intra.nida.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 169 EP - 177 VL - 91 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Heroin Dependence -- epidemiology KW - Cocaine -- urine KW - Social Adjustment KW - Humans KW - Patient Dropouts KW - Depression -- epidemiology KW - Adult KW - Reinforcement (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Monitoring, Physiologic -- methods KW - Social Support KW - Cocaine-Related Disorders -- prevention & control KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68389080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Psychosocial+functioning+and+cocaine+use+during+treatment%3A+strength+of+relationship+depends+on+type+of+urine-testing+method.&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-12-01&rft.volume=91&rft.issue=2-3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-01 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Anal Toxicol. 2000 Oct;24(7):467-77 [11043648] Drug Alcohol Depend. 2009 Apr 1;101(1-2):92-100 [19101098] Int J Neurosci. 2001;106(3-4):253-63 [11264924] J Addict Dis. 2002;21(2):17-26 [11916369] J Consult Clin Psychol. 2002 Apr;70(2):398-405 [11952198] Drug Alcohol Depend. 2002 Jul 1;67(2):125-37 [12095662] J Subst Abuse Treat. 2002 Oct;23(3):171-81 [12392803] Exp Clin Psychopharmacol. 2003 Aug;11(3):195-201 [12940498] Am J Addict. 2004 Jan-Feb;13(1):74-82 [14766440] Arch Gen Psychiatry. 1976 Sep;33(9):1111-5 [962494] J Nerv Ment Dis. 1978 May;166(5):317-26 [650195] Arch Gen Psychiatry. 1981 Nov;38(11):1250-8 [7305605] J Nerv Ment Dis. 1983 Feb;171(2):97-104 [6822825] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):876-81 [4045482] Arch Gen Psychiatry. 1986 Aug;43(8):739-45 [3729668] J Am Acad Child Adolesc Psychiatry. 1988 Jan;27(1):49-54 [3343206] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] J Affect Disord. 1991 Nov;23(3):137-49 [1774429] Am J Psychiatry. 1992 Sep;149(9):1148-56 [1386964] Int Psychogeriatr. 1992 Fall;4(2):177-85 [1477305] Drug Alcohol Depend. 2000 Apr 1;59(1):63-75 [10706976] J Affect Disord. 2000 Jan-Mar;57(1-3):261-5 [10708841] Drug Alcohol Depend. 1996 Jun;41(2):157-65 [8809505] Psychopharmacol Bull. 1995;31(4):671-9 [8851639] J Consult Clin Psychol. 1997 Apr;65(2):252-61 [9086688] Addiction. 1997 Mar;92(3):297-302 [9219391] NIDA Res Monogr. 1997;167:130-45 [9243560] Addiction. 1997 Jun;92(6):717-27 [9246799] NIDA Res Monogr. 1997;175:253-64 [9467803] J Consult Clin Psychol. 1998 Aug;66(4):691-6 [9735588] Am J Psychiatry. 1998 Oct;155(10):1446-8 [9766781] Biol Psychiatry. 2004 Nov 15;56(10):803-9 [15556126] Contemp Clin Trials. 2006 Feb;27(1):1-12 [16236557] J Anal Toxicol. 2006 Sep;30(7):458-62 [16959139] Am J Psychiatry. 2001 Mar;158(3):460-6 [11229989] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intratumoral delivery of vector mediated IL-2 in combination with vaccine results in enhanced T cell avidity and anti-tumor activity. AN - 68338267; 17503041 AB - Systemic IL-2 is currently employed in the therapy of several tumor types, but at the price of often severe toxicities. Local vector mediated delivery of IL-2 at the tumor site may enhance local effector cell activity while reducing toxicity. To examine this, a model using CEA-transgenic mice bearing established CEA expressing tumors was employed. The vaccine regimen was a s.c. prime vaccination with recombinant vaccinia (rV) expressing transgenes for CEA and a triad of costimulatory molecules (TRICOM) followed by i.t. boosting with rF-CEA/TRICOM. The addition of intratumoral (i.t.) delivery of IL-2 via a recombinant fowlpox (rF) IL-2 vector greatly enhanced anti-tumor activity of a recombinant vaccine, resulting in complete tumor regression in 70-80% of mice. The anti-tumor activity was shown to be dependent on CD8(+) cells and NK1.1(+). Cellular immune assays revealed that the addition of rF-IL-2 to the vaccination therapy enhanced CEA-specific tetramer(+) cell numbers, cytokine release and CTL lysis of CEA(+) targets. Moreover, tumor-bearing mice vaccinated with the CEA/TRICOM displayed an antigen cascade, i.e., CD8(+) T cell responses to two other antigens expressed on the tumor and not the vaccine: wild-type p53 and endogenous retroviral antigen gp70. Mice receiving rF-IL-2 during vaccination demonstrated higher avidity CEA-specific, as well as higher avidity gp70-specific, CD8(+) T cells when compared with mice vaccinated without rF-IL-2. These studies demonstrate for the first time that the level and avidity of antigen specific CTL, as well as the therapeutic outcome can be improved with the use of i.t. rF-IL-2 with vaccine regimens. JF - Cancer immunology, immunotherapy : CII AU - Kudo-Saito, Chie AU - Garnett, Charlie T AU - Wansley, Elizabeth K AU - Schlom, Jeffrey AU - Hodge, James W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1897 EP - 1910 VL - 56 IS - 12 SN - 0340-7004, 0340-7004 KW - Cancer Vaccines KW - 0 KW - Interleukin-2 KW - Index Medicus KW - Animals KW - CD4-Positive T-Lymphocytes -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Genetic Vectors KW - Mice, Inbred C57BL KW - Fowlpox -- microbiology KW - Mice KW - Flow Cytometry KW - Immune System KW - Interleukin-2 -- metabolism KW - Interleukin-2 -- therapeutic use KW - Genetic Therapy -- methods KW - Neoplasms -- therapy KW - T-Lymphocytes -- immunology KW - Neoplasms -- immunology KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Intratumoral+delivery+of+vector+mediated+IL-2+in+combination+with+vaccine+results+in+enhanced+T+cell+avidity+and+anti-tumor+activity.&rft.au=Kudo-Saito%2C+Chie%3BGarnett%2C+Charlie+T%3BWansley%2C+Elizabeth+K%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Kudo-Saito&rft.aufirst=Chie&rft.date=2007-12-01&rft.volume=56&rft.issue=12&rft.spage=1897&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammation and cancer: an ancient link with novel potentials. AN - 68334055; 17893866 AB - Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Hussain, S Perwez AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 2373 EP - 2380 VL - 121 IS - 11 KW - Cytokines KW - 0 KW - Free Radicals KW - Inflammation Mediators KW - Intercellular Signaling Peptides and Proteins KW - MicroRNAs KW - NF-kappa B KW - Prostaglandins KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Animals KW - Free Radicals -- adverse effects KW - Humans KW - Disease Progression KW - Cytokines -- metabolism KW - Immunity, Innate KW - Epigenesis, Genetic KW - Risk Assessment KW - DNA Methylation KW - Risk Factors KW - Genes, p53 -- genetics KW - Point Mutation KW - Chronic Disease KW - Cyclooxygenase 2 -- metabolism KW - Nitric Oxide Synthase -- metabolism KW - Signal Transduction KW - Prostaglandins -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - NF-kappa B -- metabolism KW - Inflammation -- parasitology KW - Neoplasms -- virology KW - Inflammation -- virology KW - Inflammation Mediators -- adverse effects KW - Neoplasms -- microbiology KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Inflammation -- complications KW - Neoplasms -- metabolism KW - Neoplasms -- immunology KW - Inflammation Mediators -- metabolism KW - Inflammation -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68334055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Inflammation+and+cancer%3A+an+ancient+link+with+novel+potentials.&rft.au=Hussain%2C+S+Perwez%3BHarris%2C+Curtis+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2007-12-01&rft.volume=121&rft.issue=11&rft.spage=2373&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitrate in public water supplies and the risk of renal cell carcinoma. AN - 68332393; 17717631 AB - Drinking water and dietary sources of nitrate and nitrite can react in vivo with amines and amides to form N-nitroso compounds (NOC), potent animal carcinogens. Nitrate is a widespread contaminant of drinking water supplies especially in agricultural areas. We conducted a population-based case-control study of renal cell carcinoma in 1986-1989 in Iowa, a state with elevated levels in many public water supplies. We collected a lifetime water source history, but due to limited monitoring data, most analyses focused on the subpopulation, who used Iowa public supplies with nitrate measurements (actual or imputed data) for > or = 70% of their person-years since 1960 (201 cases, 1,244 controls). We computed the average nitrate level and years using a public supply with nitrate levels >5 and >10 mg/l. Dietary nitrate and nitrite were estimated from a 55-item food frequency questionnaire. There was no association of renal cell carcinoma with the average nitrate level and years using public supplies >5 and >10 mg/l nitrate-nitrogen (10+ years >5 mg/l odds ratio (OR) = 1.03, 95% confidence interval (CI) 0.66, 1.60). However, higher nitrate exposure was associated with an increased risk among subgroups with above the median red meat intake (10+ years >5 mg/l OR = 1.91, 95% CI 1.04-3.51) or below the median vitamin C intake (10+ years >5 mg/l OR = 1.90, 95% CI 1.01, 3.56), dietary factors that increase the endogenous formation of NOC. Exclusion of long-term Des Moines residents, a large proportion of the high exposure categories, attenuated the association. These findings deserve additional study in populations with high water nitrate intake and information on dietary intakes. JF - Cancer causes & control : CCC AU - Ward, Mary H AU - Rusiecki, Jennifer A AU - Lynch, Charles F AU - Cantor, Kenneth P AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. wardm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1141 EP - 1151 VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Amines KW - 0 KW - Nitrates KW - Nitroso Compounds KW - Water Pollutants, Chemical KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Nitroso Compounds -- metabolism KW - Humans KW - Amines -- metabolism KW - Retrospective Studies KW - Aged KW - Iowa KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Food Contamination KW - Middle Aged KW - Female KW - Male KW - Carcinoma, Renal Cell -- chemically induced KW - Kidney Neoplasms -- chemically induced KW - Water Pollutants, Chemical -- adverse effects KW - SEER Program KW - Nitrates -- metabolism KW - Water Supply KW - Kidney Neoplasms -- epidemiology KW - Nitrates -- adverse effects KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68332393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Nitrate+in+public+water+supplies+and+the+risk+of+renal+cell+carcinoma.&rft.au=Ward%2C+Mary+H%3BRusiecki%2C+Jennifer+A%3BLynch%2C+Charles+F%3BCantor%2C+Kenneth+P&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=09575243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II clinical trial of ZD1839 (Iressa) in combination with docetaxel as first-line treatment in patients with advanced breast cancer. AN - 68326862; 17563856 AB - This was a phase II multi-institutional trial to determine the efficacy and tolerability of gefitinib (Iressatrade) and docetaxel as first-line treatment in patients with metastatic breast cancer. All patients had histologically confirmed breast cancer with metastatic disease. They were permitted to have received adjuvant chemotherapy, but no prior docetaxel or prior chemotherapy for metastatic disease. Patients received gefitinib 250 mg once daily and docetaxel 75 mg/m(2) every 3 weeks, until tumor progression, toxicity or other reasons for discontinuation. Thirty-three patients were enrolled and received a median of 5 cycles of treatment. The clinical benefit rate was 51.5% (95% CI: 33.5-69.2%). There were 1 confirmed complete response and 12 confirmed partial responses, and the overall objective response rate was 39.4% (95% CI: 22.9-57.9%). Four patients had stable disease for > or =24 weeks. The median duration of clinical benefit was 10.9 months (95% CI: 6.0-17.6 months). The most common reason for study discontinuation was disease progression (16 patients), followed by toxicity (ten patients). Toxicities were mainly attributable to docetaxel, including > or =grade 3 neutropenia in 43% of patients. The combination of gefitinib and docetaxel is an active regimen in patients with previously untreated metastatic breast cancer, with a clinical benefit rate and toxicity profile in the range of that reported for docetaxel alone. JF - Investigational new drugs AU - Dennison, Sheri K AU - Jacobs, Samuel A AU - Wilson, John W AU - Seeger, Janell AU - Cescon, Terrence P AU - Raymond, Jane M AU - Geyer, Charles E AU - Wolmark, Norman AU - Swain, Sandra M AD - Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, DC 20307, USA. dennisonsk@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 545 EP - 551 VL - 25 IS - 6 SN - 0167-6997, 0167-6997 KW - Quinazolines KW - 0 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Humans KW - Breast Neoplasms, Male -- drug therapy KW - Disease Progression KW - Aged KW - Neutropenia -- chemically induced KW - Taxoids -- administration & dosage KW - Breast Neoplasms, Male -- pathology KW - Quinazolines -- administration & dosage KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Female KW - Male KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68326862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=A+phase+II+clinical+trial+of+ZD1839+%28Iressa%29+in+combination+with+docetaxel+as+first-line+treatment+in+patients+with+advanced+breast+cancer.&rft.au=Dennison%2C+Sheri+K%3BJacobs%2C+Samuel+A%3BWilson%2C+John+W%3BSeeger%2C+Janell%3BCescon%2C+Terrence+P%3BRaymond%2C+Jane+M%3BGeyer%2C+Charles+E%3BWolmark%2C+Norman%3BSwain%2C+Sandra+M&rft.aulast=Dennison&rft.aufirst=Sheri&rft.date=2007-12-01&rft.volume=25&rft.issue=6&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00052169; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spousal concordance for substance use and anxiety disorders. AN - 68182937; 17204289 AB - Assortative mating -- the tendency for mate selection to occur on the basis of similar traits -- plays an essential role in understanding the genetic contribution to psychiatric illness. It also carries significant impact on clinical prognosis and is an important mechanism explaining spousal concordance. This study uses a family study design ascertaining 225 probands with substance abuse/dependence, anxiety disorders, and controls to address: (1) Is there spousal concordance or cross-concordance for substance use and/or anxiety disorders? (2) Is the spousal concordance or cross-concordance associated with worse clinical outcomes? (3) What is the mechanism of the concordance or cross-concordance? Results show a high magnitude of spousal concordance for substance use disorders with a third of the substance probands' spouses also substance dependent. In contrast, there was no spousal concordance for anxiety disorders. Couples were also concordant for having "no disorders." Both substance use and anxiety disorder concordance were associated with poorer global functioning and persistent illness. Assortative mating is a likely mechanism for spousal concordance given the elevated rate of substance use disorders among the relatives of spouses' of substance probands. Implications for family/genetic studies and the transmission of substance use disorders and "no disorders" include: (1) at the individual level, spousal concordance influences probands' course of illness, couples' marital functioning, and offspring's genetic and environmental context; and (2) at the population level, it shifts the general distribution of substance use disorders and "no disorders" by reducing the "average" couple concordance and increasing the number concordant and discordant couples at extremes of the distribution. JF - Journal of psychiatric research AU - Low, Nancy AU - Cui, Lihong AU - Merikangas, Kathleen R AD - Section on Developmental Genetic Epidemiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. Nancy.Low@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 942 EP - 951 VL - 41 IS - 11 SN - 0022-3956, 0022-3956 KW - Index Medicus KW - Humans KW - Marriage -- statistics & numerical data KW - Comorbidity KW - Mood Disorders -- genetics KW - Phenotype KW - Interview, Psychological KW - Marriage -- psychology KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Mood Disorders -- epidemiology KW - Mood Disorders -- psychology KW - Female KW - Male KW - Anxiety Disorders -- genetics KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Spouses -- statistics & numerical data KW - Spouses -- psychology KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- epidemiology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Spousal+concordance+for+substance+use+and+anxiety+disorders.&rft.au=Low%2C+Nancy%3BCui%2C+Lihong%3BMerikangas%2C+Kathleen+R&rft.aulast=Low&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=41&rft.issue=11&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mixed Race: Understanding Difference in the Genome Era AN - 61695244; 200823099 AB - This article presents the findings of a qualitative study of multiracial individuals' understanding of identity, race & human genetic variation. The debate regarding the correlation between race, genetics & disease has expanded, but limited empirical data has been collected regarding the lay public's perspective. Participants in this study explore their identity & its relationships to their health care interactions. Participants also share their views on race-based therapeutics, health disparities & the connections between race, ancestry & genetics. Their voices highlight the limitations of racial categories in describing differences within our increasingly diverse communities. The genomic era will be a pivotal period in challenging current understandings & uses of racial categories in health. Tables, References. Adapted from the source document. JF - Social Forces AU - Phillips, Elizabeth M AU - Odunlami, Adebola O AU - Bonham, Vence L AD - c/o Bonham -- Division Intramural Research, National Humkan Genome Research Instit, NIH, Bethesda, MD Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 795 EP - 820 PB - University of North Carolina Press, Chapel Hill VL - 86 IS - 2 SN - 0037-7732, 0037-7732 KW - Genetics KW - Classification KW - Multiraciality KW - Identity KW - article KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61695244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Forces&rft.atitle=Mixed+Race%3A+Understanding+Difference+in+the+Genome+Era&rft.au=Phillips%2C+Elizabeth+M%3BOdunlami%2C+Adebola+O%3BBonham%2C+Vence+L&rft.aulast=Phillips&rft.aufirst=Elizabeth&rft.date=2007-12-01&rft.volume=86&rft.issue=2&rft.spage=795&rft.isbn=&rft.btitle=&rft.title=Social+Forces&rft.issn=00377732&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2008-09-03 N1 - Number of references - 59 N1 - Last updated - 2016-09-28 N1 - CODEN - SOFOAP N1 - SubjectsTermNotLitGenreText - Multiraciality; Identity; Genetics; Classification ER - TY - JOUR T1 - Kremlin Inc.: Gaming the Energy Landscape TT - Kremlin Inc.: le systeme juridique au service de l'industrie energetique AN - 59785972; 200805361 AB - The "come-back" of Russian power fuels speculation. The Kremlin seems to have a commercial predation policy, dedicated to its internal & foreign policy. A giant holding is emerging, systematically trying to control, upstream & downstream, the greatest part of the energy sector. Helped by numerous juridic advisors, it tries to trap capitalism with its own logic. Adapted from the source document. JF - Politique etrangere AU - Dellecker, Adrian AD - Centre Russie/NEI Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 851 EP - 862 PB - Armand Colin, France IS - 4 SN - 0032-342X, 0032-342X KW - Capitalism KW - Russia KW - Energy Policy KW - article KW - 9003: history and theory; political theories and philosophy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59785972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=Kremlin+Inc.%3A+Gaming+the+Energy+Landscape&rft.au=Dellecker%2C+Adrian&rft.aulast=Dellecker&rft.aufirst=Adrian&rft.date=2007-12-01&rft.volume=&rft.issue=4&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2008-03-05 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Russia; Energy Policy; Capitalism ER - TY - JOUR T1 - Subtypes of alcohol dependence in a nationally representative sample AN - 57243271; 200810524 AB - Objective: The authors sought to empirically derive alcohol dependence (AD) subtypes based on clinical characteristics using data from a nationally representative epidemiological survey. Method A sample of 1484 respondents to the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) with past year AD was subjected to latent class analysis in order to identify homogeneous subtypes. Results The best-fitting model was a five-cluster solution. The largest cluster (Cluster 1: 31%) was comprised of young adults, who rarely sought help for drinking, had moderately high levels of periodic heavy drinking, relatively low rates of comorbidity, and the lowest rate of multigenerational AD (22%). In contrast, Clusters 4 and 5 (21% and 9%, respectively) had substantial rates of multigenerational AD (53% and 77%, respectively), had the most severe AD criteria profile, were associated with both comorbid psychiatric and other drug use disorders, lower levels of psychosocial functioning, and had engaged in significant help-seeking. Clusters 2 and 3 (19% each) had the latest onset, the lowest rates of periodic heavy drinking, medium/low levels of comorbidity, moderate levels of help-seeking, and higher psychosocial functioning. Conclusion Five distinct subtypes of AD were derived, distinguishable on the basis of family history, age of AD onset, endorsement of DSM-IV AUD criteria, and the presence of comorbid psychiatric and substance use disorders. These clinically relevant subtypes, derived from the general population, may enhance our understanding of the etiology, treatment, natural history, and prevention of AD and inform the DSM-V research agenda. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Moss, Howard B AU - Chen, Chiung M AU - Yi, Hsiao-ye AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA mossh@mail.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 149 EP - 158 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 91 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Alcohol dependence KW - Epidemiology KW - Subtypes KW - Survey research KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57243271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Subtypes+of+alcohol+dependence+in+a+nationally+representative+sample&rft.au=Moss%2C+Howard+B%3BChen%2C+Chiung+M%3BYi%2C+Hsiao-ye&rft.aulast=Moss&rft.aufirst=Howard&rft.date=2007-12-01&rft.volume=91&rft.issue=2-3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.05.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Subtypes; Alcohol dependence; Epidemiology DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.05.016 ER - TY - JOUR T1 - Research Knowledge Among the Participants in the Treatment for Adolescents With Depression Study (TADS) AN - 57241247; 200812953 AB - Objective: We examined the extent to which parents and adolescents participating in the Treatment for Adolescents With Depression Study (TADS) understood key aspects of the study. Method: TADS was a clinical trial comparing the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), their combination, and placebo in 439 adolescents (12-17 years old) with major depressive disorder. Six weeks after starting treatment, adolescents and their parents were asked to complete a questionnaire about critical elements of the trial. Results: Completion rate was 67.2% for adolescents -- N = 295) and 73.6% for parents (N = 323). More than 90% of the completers knew of the main purpose of the trial, possible assignment to placebo, and their right to withdraw participation at any time. However, about one third overall (and 49% in the CBT group) described TADS as "education" rather than "research." Of 12 questions, the mean number of correct answers was 10.3 (SD 1.7) among adolescents and 11.2 (SD 1.2) among parents (p < .0001). The most frequently stated reason for TADS participation was the pursuit of high-quality care. Conclusions: Most parents and adolescents were well-informed research participants. Difficulties in appreciating the research nature of the trial, however, emerged, especially among participants assigned to psychotherapy. Parents were overall better informed than adolescents. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AU - Kratochvil, Christopher J AU - Silva, Susan AU - Curry, John AU - Reinecke, Mark AU - Pathak, Sanjeev AU - Waslick, Bruce AU - Hughes, Carroll W AU - Prentice, Ernest D AU - May, Diane E AU - March, John S AD - National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda, MD 20892-9633 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1642 EP - 1650 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 46 IS - 12 SN - 0890-8567, 0890-8567 KW - depression, treatment, ethics KW - Fluoxetine KW - Cognitive behaviour therapy KW - Depression KW - Ethics KW - Parents KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57241247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Research+Knowledge+Among+the+Participants+in+the+Treatment+for+Adolescents+With+Depression+Study+%28TADS%29&rft.au=Vitiello%2C+Benedetto%3BKratochvil%2C+Christopher+J%3BSilva%2C+Susan%3BCurry%2C+John%3BReinecke%2C+Mark%3BPathak%2C+Sanjeev%3BWaslick%2C+Bruce%3BHughes%2C+Carroll+W%3BPrentice%2C+Ernest+D%3BMay%2C+Diane+E%3BMarch%2C+John+S&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-12-01&rft.volume=46&rft.issue=12&rft.spage=1642&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b013e318153f8c7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adolescents; Parents; Depression; Ethics; Cognitive behaviour therapy; Fluoxetine DO - http://dx.doi.org/10.1097/chi.0b013e318153f8c7 ER - TY - JOUR T1 - Donation Intentions among African American College Students: Decisional Balance and Self-efficacy Measures AN - 57235820; 200811665 AB - Although the need for transplantation among African Americans is high, their donation rates are disproportionately low. This study describes the development and validation of culturally adapted psychosocial measures, including Transtheoretical Model constructs, Stages of Change, Decisional Balance, and Self-efficacy, related to deceased organ and tissue donation for an African American college population. Exploratory and confirmatory analyses for Decisional Balance and Self-efficacy measures demonstrated factor structures similar to previous studies of other behavioral applications, indicated excellent model fit and showed good internal and external validity. This study developed brief measures with good psychometric properties for an emerging behavior change domain in a new population. Adapted from the source document. JF - Journal of Behavioral Medicine AU - Hall, Kara L AU - Robbins, Mark L AU - Paiva, Andrea AU - Knott, J Eugene AU - Harris, Lorna AU - Mattice, Burton AD - University of Rhode Island, Kingston, RI, USA hallka@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 483 EP - 495 PB - Springer Science+Business Media, Inc., Dordrecht, The Netherlands VL - 30 IS - 6 SN - 0160-7715, 0160-7715 KW - Selfefficacy KW - Black American people KW - Donations KW - Transtheoretical model KW - Transplants KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57235820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Donation+Intentions+among+African+American+College+Students%3A+Decisional+Balance+and+Self-efficacy+Measures&rft.au=Hall%2C+Kara+L%3BRobbins%2C+Mark+L%3BPaiva%2C+Andrea%3BKnott%2C+J+Eugene%3BHarris%2C+Lorna%3BMattice%2C+Burton&rft.aulast=Hall&rft.aufirst=Kara&rft.date=2007-12-01&rft.volume=30&rft.issue=6&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-007-9121-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JBMEDD N1 - SubjectsTermNotLitGenreText - Undergraduate students; Transplants; Donations; Selfefficacy; Black American people; Transtheoretical model DO - http://dx.doi.org/10.1007/s10865-007-9121-8 ER - TY - CPAPER T1 - Neuromuscular Junction Defects in Emery-Dreyfuss Muscular Dystrophy T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39774072; 4738741 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mejat, A AU - Decostre, V AU - Kesari, A AU - Hoffman, E AU - Bonne, G AU - Stewart, C L AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Muscular dystrophy KW - Neuromuscular junctions KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Neuromuscular+Junction+Defects+in+Emery-Dreyfuss+Muscular+Dystrophy&rft.au=Mejat%2C+A%3BDecostre%2C+V%3BKesari%2C+A%3BHoffman%2C+E%3BBonne%2C+G%3BStewart%2C+C+L%3BMisteli%2C+T&rft.aulast=Mejat&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dictyostelium Chemotaxis is Regulated and Sensitized by Extracellular Signal Degradation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39773452; 4738596 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Garcia, G L AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chemotaxis KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dictyostelium+Chemotaxis+is+Regulated+and+Sensitized+by+Extracellular+Signal+Degradation&rft.au=Garcia%2C+G+L%3BParent%2C+C+A&rft.aulast=Garcia&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Mammalian Polo-like Kinase 1 (Plk1) Localization: Self- versus Non-self-Priming T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39772417; 4738829 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Park, J AU - Kang, Y AU - Erikson, R AU - Lee, K S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mechanisms+of+Mammalian+Polo-like+Kinase+1+%28Plk1%29+Localization%3A+Self-+versus+Non-self-Priming&rft.au=Park%2C+J%3BKang%2C+Y%3BErikson%2C+R%3BLee%2C+K+S&rft.aulast=Park&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39771280; 4739016 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mears, J A AU - Ray, P AU - Fang, S AU - Hinshaw, J E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structural analysis KW - Membranes KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39771280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Structural+Analysis+of+Dynamin+Family+Members+Offers+Insight+into+Membrane+Fission&rft.au=Mears%2C+J+A%3BRay%2C+P%3BFang%2C+S%3BHinshaw%2C+J+E&rft.aulast=Mears&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAM Proteins Function in ER-to-Golgi Trafficking through Interactions with COPII Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39767272; 4740280 DE: JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rismanchi, N AU - Puertollano, R AU - Blackstone, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=STAM+Proteins+Function+in+ER-to-Golgi+Trafficking+through+Interactions+with+COPII+Complexes&rft.au=Rismanchi%2C+N%3BPuertollano%2C+R%3BBlackstone%2C+C&rft.aulast=Rismanchi&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arf6 and Arf1 Interact with the Plasma Membrane t-SNARE Syntaxin 4 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39767006; 4740256 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Eyster, C A AU - Honda, A AU - Weigert, R AU - Donaldson, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Plasma membranes KW - Syntaxin 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Arf6+and+Arf1+Interact+with+the+Plasma+Membrane+t-SNARE+Syntaxin+4&rft.au=Eyster%2C+C+A%3BHonda%2C+A%3BWeigert%2C+R%3BDonaldson%2C+J+G&rft.aulast=Eyster&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brucella Intracellular Replication Requires Trafficking through the Late Endocytic/Lysosomal Compartment T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39719323; 4741069 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Starr, T AU - Ng, T W AU - Wehrly, T D AU - Knodler, L A AU - Celli, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Replication KW - Brucella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Brucella+Intracellular+Replication+Requires+Trafficking+through+the+Late+Endocytic%2FLysosomal+Compartment&rft.au=Starr%2C+T%3BNg%2C+T+W%3BWehrly%2C+T+D%3BKnodler%2C+L+A%3BCelli%2C+J&rft.aulast=Starr&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Characterization, Expression, and Functional Analyses of LdNucs: A Novel Class-I Secretory Nuclease from the Human Pathogen Leishmania donovani T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39718759; 4740998 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Joshi, M B AU - Owings, J P AU - Dwyer, D M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pathogens KW - Functional analysis KW - Nuclease KW - Leishmania donovani KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39718759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Molecular+Characterization%2C+Expression%2C+and+Functional+Analyses+of+LdNucs%3A+A+Novel+Class-I+Secretory+Nuclease+from+the+Human+Pathogen+Leishmania+donovani&rft.au=Joshi%2C+M+B%3BOwings%2C+J+P%3BDwyer%2C+D+M&rft.aulast=Joshi&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Histone Modifications Surrounding a Suppressor of Hairy Wing Chromatin Insulator T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39695277; 4740862 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Emmett, M J AU - Lei, E P Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Wings KW - Histones KW - Chromatin KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Analysis+of+Histone+Modifications+Surrounding+a+Suppressor+of+Hairy+Wing+Chromatin+Insulator&rft.au=Emmett%2C+M+J%3BLei%2C+E+P&rft.aulast=Emmett&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin-mediated Endocytosis is Required for Sea Urchin Embryo Cytokinesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39695057; 4740835 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Covian-Nares, J F AU - Vogel, S S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Embryos KW - Endocytosis KW - Cytokinesis KW - Marine invertebrates KW - Echinoidea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamin-mediated+Endocytosis+is+Required+for+Sea+Urchin+Embryo+Cytokinesis&rft.au=Covian-Nares%2C+J+F%3BVogel%2C+S+S&rft.aulast=Covian-Nares&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Histone Modifications in Epigenetic Control of Nodal Gene Expression T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39685300; 4739233 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Dahle, O AU - Kuehn, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Histones KW - Nodal gene KW - Epigenetics KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39685300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Role+of+Histone+Modifications+in+Epigenetic+Control+of+Nodal+Gene+Expression&rft.au=Dahle%2C+O%3BKuehn%2C+M&rft.aulast=Dahle&rft.aufirst=O&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Caspase-dependent Cleavage Disrupts the ERK Scaffolding Function of KSR1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39681949; 4741001 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McKay, M AU - Morrison, D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39681949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Caspase-dependent+Cleavage+Disrupts+the+ERK+Scaffolding+Function+of+KSR1&rft.au=McKay%2C+M%3BMorrison%2C+D&rft.aulast=McKay&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulated Diffusion of CaMKII in Dendritic Spines T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39677750; 4741097 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yixiao, Z AU - Reese, T AU - Khan, S M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Diffusion KW - Dendritic spines KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39677750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Simulated+Diffusion+of+CaMKII+in+Dendritic+Spines&rft.au=Yixiao%2C+Z%3BReese%2C+T%3BKhan%2C+S+M&rft.aulast=Yixiao&rft.aufirst=Z&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Smad3 by GSK3-mediated Phosphorylation at its Linker Region T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39674582; 4739733 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Millet, C A AU - Yamashita, M AU - Yu, L. AU - Veenstra, T AU - Heller, M AU - Zhang, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Phosphorylation KW - Smad3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Regulation+of+Smad3+by+GSK3-mediated+Phosphorylation+at+its+Linker+Region&rft.au=Millet%2C+C+A%3BYamashita%2C+M%3BYu%2C+L.%3BVeenstra%2C+T%3BHeller%2C+M%3BZhang%2C+Y&rft.aulast=Millet&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of Nonmuscle Myosin II Heavy Chain Isoforms Using Mass Spectroscopy T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39656879; 4740474 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Conti, M AU - Zhang, Y AU - Wang, G AU - Shen, R AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mass spectroscopy KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39656879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Quantification+of+Nonmuscle+Myosin+II+Heavy+Chain+Isoforms+Using+Mass+Spectroscopy&rft.au=Conti%2C+M%3BZhang%2C+Y%3BWang%2C+G%3BShen%2C+R%3BAdelstein%2C+R+S&rft.aulast=Conti&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Palmitoylation is Required for the Retrograde Transport of the Lysosomal Sorting Receptors T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39641468; 4740981 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McCormick, P J AU - Dumaresq-Doiron, K AU - Pluviose, A AU - Lefrancois, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Palmitoylation KW - Retrograde transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39641468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Xu%2C+Long&rft.aulast=Xu&rft.aufirst=Long&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Su+Shi%3A+Major+Creative+and+Critical+Insights+and+Theories&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Insulin and CL316243 (b3-Receptor Agonist) on Activation of Adipocyte PDE3B Associated with Caveolae and Internal Membranes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39637516; 4740855 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Khan, F A AU - Lindh, R AU - Degerman, E AU - Tang, Y AU - Manganiello, V Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Insulin KW - Caveolae KW - Adipocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+Insulin+and+CL316243+%28b3-Receptor+Agonist%29+on+Activation+of+Adipocyte+PDE3B+Associated+with+Caveolae+and+Internal+Membranes&rft.au=Khan%2C+F+A%3BLindh%2C+R%3BDegerman%2C+E%3BTang%2C+Y%3BManganiello%2C+V&rft.aulast=Khan&rft.aufirst=F&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxysterol Binding Protein Homologs Localize to Organellar Junctions and Mediate Contacts with Lipid Droplets T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39637478; 4740829 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Schulz, T A AU - Prinz, W A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lipids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=A+role+for+conditioned+ventral+tegmental+glutamate+release+in+cocaine+seeking.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BAzari%2C+Soraya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2007-09-26&rft.volume=27&rft.issue=39&rft.spage=10546&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Homologous Recombination to Replace Nonmuscle Myosin II-A with Human GFP-Myosin II-B in Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636905; 4740472 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wang, A AU - Ma, X. AU - Liu, C AU - Pinto, Y AU - Adelstein, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - Myosin KW - Homologous recombination KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Pater%27s+Critical+Foresight%3A+Style%2C+Insight+and+Complexity&rft.au=De+Scarpis%2C+Valerio&rft.aulast=De+Scarpis&rft.aufirst=Valerio&rft.date=1996-01-01&rft.volume=&rft.issue=&rft.spage=215&rft.isbn=9788820507831&rft.btitle=Walter+Pater+%281839-1894%29%3A+Le+forme+della+modernit%C3%A0%2FThe+Forms+of+Modernity&rft.title=Walter+Pater+%281839-1894%29%3A+Le+forme+della+modernit%C3%A0%2FThe+Forms+of+Modernity&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Vertebrate Nup93 Nuclear Pore Sub-complex T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636890; 4740894 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yoon, H AU - Quimby, B AU - Arnaoutov, A AU - Dasso, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclear pores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+the+Vertebrate+Nup93+Nuclear+Pore+Sub-complex&rft.au=Yoon%2C+H%3BQuimby%2C+B%3BArnaoutov%2C+A%3BDasso%2C+M&rft.aulast=Yoon&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Imaging of Receptor-G Protein Interactions: Single-Molecule Microscopy Reveals Dynamic Interactions between Chemoattractant GPCR and Heterotrimeric G-proteins in Membrane of Living Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636664; 4740811 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Xu, X. AU - Brzostowski, J A AU - Meckel, T AU - Tolar, P AU - Yan, J AU - Jin, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Microscopy KW - Chemotactic factors KW - Protein interaction KW - Imaging techniques KW - G protein-coupled receptors KW - Guanine nucleotide-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Imaging+of+Receptor-G+Protein+Interactions%3A+Single-Molecule+Microscopy+Reveals+Dynamic+Interactions+between+Chemoattractant+GPCR+and+Heterotrimeric+G-proteins+in+Membrane+of+Living+Cells&rft.au=Xu%2C+X.%3BBrzostowski%2C+J+A%3BMeckel%2C+T%3BTolar%2C+P%3BYan%2C+J%3BJin%2C+T&rft.aulast=Xu&rft.aufirst=X.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pin1 Dependent Prolyl Isomerization Modulates the Stress Induced Phosphorylation of NF-H: A Role in Neurodegenerative Disorders T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636086; 4740515 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rudrabhatla, P AU - Zheng, Y AU - Amin, N AU - Grant, P AU - Albers, W AU - Kesavapany, S AU - Pant, H C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stress KW - Neurodegenerative diseases KW - Isomerization KW - Pin1 protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Pin1+Dependent+Prolyl+Isomerization+Modulates+the+Stress+Induced+Phosphorylation+of+NF-H%3A+A+Role+in+Neurodegenerative+Disorders&rft.au=Rudrabhatla%2C+P%3BZheng%2C+Y%3BAmin%2C+N%3BGrant%2C+P%3BAlbers%2C+W%3BKesavapany%2C+S%3BPant%2C+H+C&rft.aulast=Rudrabhatla&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imbalanced Expression and Mis-localization of Histone H3 and its Variant Cse4p Lead to Defects in Chromosome Transmission Fidelity T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39635818; 4739668 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Au, W. AU - DeLuca, S AU - Crisp, M AU - Rando, O AU - Basrai, M A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lead KW - Chromosomes KW - Fidelity KW - Histone H3 KW - Defects KW - Histones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39635818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Imbalanced+Expression+and+Mis-localization+of+Histone+H3+and+its+Variant+Cse4p+Lead+to+Defects+in+Chromosome+Transmission+Fidelity&rft.au=Au%2C+W.%3BDeLuca%2C+S%3BCrisp%2C+M%3BRando%2C+O%3BBasrai%2C+M+A&rft.aulast=Au&rft.aufirst=W.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coupling of Inositol Pyrophosphates Signal and High Energy Balance is Independent of AMP-activated Protein Kinase T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634411; 4739722 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mollapour, E AU - Choi, K AU - Shears, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pyrophosphates KW - Inositol KW - Energy balance KW - AMP-activated protein kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Coupling+of+Inositol+Pyrophosphates+Signal+and+High+Energy+Balance+is+Independent+of+AMP-activated+Protein+Kinase&rft.au=Mollapour%2C+E%3BChoi%2C+K%3BShears%2C+S&rft.aulast=Mollapour&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of Movement of DNA Sites in Yeast Nuclei T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634409; 4740120 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Campbell, J L AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Studies+of+Movement+of+DNA+Sites+in+Yeast+Nuclei&rft.au=Campbell%2C+J+L%3BCohen-Fix%2C+O&rft.aulast=Campbell&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Nesprin-1 Isoforms Localize to the Nucleolus and Disrupt the Formation of Cytoplasmic Processing Bodies T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634225; 4740118 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mellad, J A AU - Boem, M AU - Shanahan, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nucleoli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Novel+Nesprin-1+Isoforms+Localize+to+the+Nucleolus+and+Disrupt+the+Formation+of+Cytoplasmic+Processing+Bodies&rft.au=Mellad%2C+J+A%3BBoem%2C+M%3BShanahan%2C+C&rft.aulast=Mellad&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cells Increase the Number and Adhesiveness of Their "Sticky Fingers" as They Turn Toward Permissive Substrates T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633841; 4739592 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Galbraith, J AU - Galbraith, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cells+Increase+the+Number+and+Adhesiveness+of+Their+%22Sticky+Fingers%22+as+They+Turn+Toward+Permissive+Substrates&rft.au=Galbraith%2C+J%3BGalbraith%2C+C&rft.aulast=Galbraith&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Observation of the Uncapping of Capped Actin Filaments by CARMIL T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633507; 4740686 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fujiwara, I AU - Remmert, K AU - Hammer, J A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Actin KW - Filaments KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Direct+Observation+of+the+Uncapping+of+Capped+Actin+Filaments+by+CARMIL&rft.au=Fujiwara%2C+I%3BRemmert%2C+K%3BHammer%2C+J+A&rft.aulast=Fujiwara&rft.aufirst=I&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intercellular Transfer as a Mechanism of Cell Communication within the Hematopoietic Progenitor Niche T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633401; 4740610 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gillette, J M AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Niches KW - Communication KW - Hemopoiesis KW - Cell interactions KW - Intercellular signalling KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Intercellular+Transfer+as+a+Mechanism+of+Cell+Communication+within+the+Hematopoietic+Progenitor+Niche&rft.au=Gillette%2C+J+M%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2007-12-01&rft.volume=4&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Pedagogy%3A+Critical+Approaches+to+Teaching+Literature%2C+Language%2C+Composition%2C+and+Culture&rft.issn=15314200&rft_id=info:doi/10.1215%2F15314200-4-2-215 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Formation of Artificial Bone Scaffolds with Surface-modified Hydroxyapatite Crystals and Polyamine Organic Polymer for Bone Regeneration T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631845; 4741113 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lee, E AU - Sworder, B AU - Leet, A AU - Jeon, E AU - Son, Y AU - Yoon, K AU - Robey, P G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Bone growth KW - Regeneration KW - Polymers KW - Scaffolds KW - Crystals KW - Hydroxyapatite KW - Polyamines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Formation+of+Artificial+Bone+Scaffolds+with+Surface-modified+Hydroxyapatite+Crystals+and+Polyamine+Organic+Polymer+for+Bone+Regeneration&rft.au=Lee%2C+E%3BSworder%2C+B%3BLeet%2C+A%3BJeon%2C+E%3BSon%2C+Y%3BYoon%2C+K%3BRobey%2C+P+G&rft.aulast=Lee&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arylcarbonlyindoles: Antimitotic Agents and Potent Inhibitors of Tubulin Polymerization T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631356; 4740711 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sarkar, T AU - Regina, G La AU - Silvestri, R AU - Hamel, E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Antimitotic agents KW - Tubulin KW - Polymerization KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Modulating+protein+alignment+in+a+liquid-crystalline+medium+through+conservative+mutagenesis.&rft.au=Davis%2C+Lennard+J&rft.aulast=Davis&rft.aufirst=Lennard&rft.date=1995-12-01&rft.volume=57&rft.issue=8&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=College+English&rft.issn=00100994&rft_id=info:doi/10.2307%2F378619 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Zinc Regulation of the Candida albicans Developmental Regulator HBR1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631275; 4738710 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pendrak, M L AU - Roberts, D D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Zinc KW - Candida albicans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Zinc+Regulation+of+the+Candida+albicans+Developmental+Regulator+HBR1&rft.au=Pendrak%2C+M+L%3BRoberts%2C+D+D&rft.aulast=Pendrak&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serpinin, a Novel Chromogranin A (CgA)-derived Peptide Induces Granule Biogenesis in Endocrine Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631042; 4738948 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Koshimizu, H AU - Kim, T AU - Loh, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chromogranins KW - Granules KW - Biogenesis KW - Endocrinology KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Serpinin%2C+a+Novel+Chromogranin+A+%28CgA%29-derived+Peptide+Induces+Granule+Biogenesis+in+Endocrine+Cells&rft.au=Koshimizu%2C+H%3BKim%2C+T%3BLoh%2C+Y&rft.aulast=Koshimizu&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin's Role in Apical Constriction T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39629327; 4740480 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chua, J AU - Rikhy, R AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39629327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamin%27s+Role+in+Apical+Constriction&rft.au=Chua%2C+J%3BRikhy%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Chua&rft.aufirst=J&rft.date=2007-12-01&rft.volume=4&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of an Alternatively Spliced Isoform of Nonmuscle Myosin II-C, NMHC II-C2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39629297; 4740469 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Jana, S S AU - Kim, K AU - Kawamoto, S AU - Sellers, J R AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Alternative splicing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39629297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+an+Alternatively+Spliced+Isoform+of+Nonmuscle+Myosin+II-C%2C+NMHC+II-C2&rft.au=Jana%2C+S+S%3BKim%2C+K%3BKawamoto%2C+S%3BSellers%2C+J+R%3BAdelstein%2C+R+S&rft.aulast=Jana&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - cAMP Dynamics in Chemotactic Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628924; 4738597 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bagorda, A AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cyclic AMP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Manuel+Manrique+de+Lara+and+the+Tunes+of+the+Moroccan+Sephardic+Ballad+Tradition%3A+Some+Insights+into+a+Much-Needed+Critical+Edition&rft.au=Katz%2C+Israel+J&rft.aulast=Katz&rft.aufirst=Israel&rft.date=1979-01-01&rft.volume=&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=El+romancero+hoy%3A+Nuevas+fronteras%2FThe+Hispanic+Ballad+Today%3A+New+Frontiers&rft.title=El+romancero+hoy%3A+Nuevas+fronteras%2FThe+Hispanic+Ballad+Today%3A+New+Frontiers&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA Receptors Interact with Flotillin-1, a Lipid Raft-associated Protein T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628844; 4738951 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Swanwick, C AU - Shapiro, M E AU - Yi, Z. AU - Chang, K AU - Wenthold, R J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lipids KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=NMDA+Receptors+Interact+with+Flotillin-1%2C+a+Lipid+Raft-associated+Protein&rft.au=Swanwick%2C+C%3BShapiro%2C+M+E%3BYi%2C+Z.%3BChang%2C+K%3BWenthold%2C+R+J&rft.aulast=Swanwick&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Monoxide Repression of Interleukin-1beta Transcription in THP-1 Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628722; 4740013 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chhikara, M AU - Wang, S AU - Danner, R L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Carbon monoxide KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Carbon+Monoxide+Repression+of+Interleukin-1beta+Transcription+in+THP-1+Cells&rft.au=Chhikara%2C+M%3BWang%2C+S%3BDanner%2C+R+L&rft.aulast=Chhikara&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Regulated Secretion in Three-Dimensionally Grown Human Submandibular Gland Cell (HSG) T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628367; 4739297 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Aye, M AU - Weigert, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Secretion KW - Submandibular gland KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+Regulated+Secretion+in+Three-Dimensionally+Grown+Human+Submandibular+Gland+Cell+%28HSG%29&rft.au=Aye%2C+M%3BWeigert%2C+R&rft.aulast=Aye&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Architecture of the Retromer Cargo-Recognition Complex T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628310; 4739286 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hierro, A AU - Rojas, A L AU - Rojas, R AU - Murthy, M AU - Effantin, G AU - Kajava, A V AU - Steven, A C AU - Bonifacino, J S AU - Hurley, J H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structure-function relationships KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Functional+Architecture+of+the+Retromer+Cargo-Recognition+Complex&rft.au=Hierro%2C+A%3BRojas%2C+A+L%3BRojas%2C+R%3BMurthy%2C+M%3BEffantin%2C+G%3BKajava%2C+A+V%3BSteven%2C+A+C%3BBonifacino%2C+J+S%3BHurley%2C+J+H&rft.aulast=Hierro&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Role of Protein Arginine Methytransferase 1 in the Transcriptional Regulation by Thyroid Hormone Receptor during Xenopus metamorphosis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628309; 4739234 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Matsuda, H AU - Paul, B AU - Choi, C AU - Shi, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Metamorphosis KW - Hormones KW - Thyroid hormone receptors KW - Transcription KW - Gene regulation KW - Arginine KW - Life cycle KW - Amphibiotic species KW - Xenopus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Role+of+Protein+Arginine+Methytransferase+1+in+the+Transcriptional+Regulation+by+Thyroid+Hormone+Receptor+during+Xenopus+metamorphosis&rft.au=Matsuda%2C+H%3BPaul%2C+B%3BChoi%2C+C%3BShi%2C+Y&rft.aulast=Matsuda&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of RNAi Screens in the Study of Cancer-associated Processes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628090; 4740603 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Martin, S E AU - Jones, T L AU - Lorenzi, P AU - Lader, E AU - Weinstein, J AU - Pommier, Y AU - Huppi, K AU - Caplen, N J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Literary+Semantics&rft.atitle=Exploring+Image+Schemas+as+a+Critical+Concept%3A+Toward+a+Critical-Cognitive+Linguistic+Account+of+Image-Schematic+Interactions&rft.au=Tseng%2C+Ming-Yu&rft.aulast=Tseng&rft.aufirst=Ming-Yu&rft.date=2007-10-01&rft.volume=36&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Literary+Semantics&rft.issn=03417638&rft_id=info:doi/10.1515%2FJLS.2007.008 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Complexity of Phosphorylated H2AX Foci and DNA Repair Protein Assembly at DNA Double-stranded Breaks T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39627455; 4738999 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bonner, W AU - Nakamura, A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Double-strand break repair KW - DNA damage KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39627455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Complexity+of+Phosphorylated+H2AX+Foci+and+DNA+Repair+Protein+Assembly+at+DNA+Double-stranded+Breaks&rft.au=Bonner%2C+W%3BNakamura%2C+A&rft.aulast=Bonner&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vesicular Trafficking and Protein Synthesis are Required for Streaming during Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39627373; 4738989 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kriebel, P W AU - Barr, V A AU - Zhang, G AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Protein synthesis KW - Protein biosynthesis KW - Protein transport KW - Streaming KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39627373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Vesicular+Trafficking+and+Protein+Synthesis+are+Required+for+Streaming+during+Chemotaxis&rft.au=Kriebel%2C+P+W%3BBarr%2C+V+A%3BZhang%2C+G%3BParent%2C+C+A&rft.aulast=Kriebel&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Dynamin Domains T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39626316; 4739271 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ray, P AU - Fang, S AU - Mears, J A AU - Hinshaw, J E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structural analysis KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39626316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Structural+Analysis+of+Dynamin+Domains&rft.au=Ray%2C+P%3BFang%2C+S%3BMears%2C+J+A%3BHinshaw%2C+J+E&rft.aulast=Ray&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photoactivatible Thresholding: Seeing More by Seeing Less T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623904; 4739585 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Galbraith, C AU - Galbraith, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Photoactivatible+Thresholding%3A+Seeing+More+by+Seeing+Less&rft.au=Galbraith%2C+C%3BGalbraith%2C+J&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity Regulates Myosin Phosphorylation and Cell Migration in Lens Epithelial Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623770; 4740478 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Tripathi, B K AU - Zelenka, P S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cdk5+Activity+Regulates+Myosin+Phosphorylation+and+Cell+Migration+in+Lens+Epithelial+Cells&rft.au=Tripathi%2C+B+K%3BZelenka%2C+P+S&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623286; 4739005 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Burgos, P V AU - Mardones, G A AU - daSilva, L L AU - Smith, W J AU - Prabhu, Y AU - Bonifacino, J S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Alzheimer's disease KW - Amyloid precursor protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+AP4+Complex+Mediates+Sorting+of+the+Amyloid+Precursor+Protein+at+the+trans-Golgi+Network&rft.au=Burgos%2C+P+V%3BMardones%2C+G+A%3BdaSilva%2C+L+L%3BSmith%2C+W+J%3BPrabhu%2C+Y%3BBonifacino%2C+J+S&rft.aulast=Burgos&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - G1 to S Phase Cell Cycle Progression Requires a Single Electrically-coupled Mitochondrial Network with a Continuous Lumen T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623164; 4738982 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mitra, K AU - Roysam, B AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mitochondria KW - Cell cycle KW - S phase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=G1+to+S+Phase+Cell+Cycle+Progression+Requires+a+Single+Electrically-coupled+Mitochondrial+Network+with+a+Continuous+Lumen&rft.au=Mitra%2C+K%3BRoysam%2C+B%3BLippincott-Schwartz%2C+J&rft.aulast=Mitra&rft.aufirst=K&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GLA Gene Silencing and Fabry Disease T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622840; 4738700 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kim, M J AU - Luu, N AU - Kaneski, C R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Gene silencing KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=GLA+Gene+Silencing+and+Fabry+Disease&rft.au=Kim%2C+M+J%3BLuu%2C+N%3BKaneski%2C+C+R&rft.aulast=Kim&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Remodeling of Primary Cilia Membranes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622620; 4738643 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ott, C M AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Remodeling+of+Primary+Cilia+Membranes&rft.au=Ott%2C+C+M%3BLippincott-Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topologic Structure of Transmembrane Channel-like Gene 1 Protein TMC1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622097; 4739312 DE: JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Labay, V AU - Weichert, R M AU - Makishima, T AU - Griffith, A J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Topologic+Structure+of+Transmembrane+Channel-like+Gene+1+Protein+TMC1&rft.au=Labay%2C+V%3BWeichert%2C+R+M%3BMakishima%2C+T%3BGriffith%2C+A+J&rft.aulast=Labay&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of CDKN1A Expression in Keratinocytes by Distal-less 3 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621967; 4740645 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pietroni, V AU - Radoja, N AU - Rivera, Y AU - Stimpson, S J AU - Anderson, E D AU - Blumenberg, M AU - Morasso, M I Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Regulation+of+CDKN1A+Expression+in+Keratinocytes+by+Distal-less+3&rft.au=Pietroni%2C+V%3BRadoja%2C+N%3BRivera%2C+Y%3BStimpson%2C+S+J%3BAnderson%2C+E+D%3BBlumenberg%2C+M%3BMorasso%2C+M+I&rft.aulast=Pietroni&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Clathrin-Independent Endocytic Pathway as a Novel Platform for H-Ras Trafficking and Signaling T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621820; 4738489 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Porat-Shliom, N AU - Kloog, Y AU - Donaldson, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - H-Ras protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Clathrin-Independent+Endocytic+Pathway+as+a+Novel+Platform+for+H-Ras+Trafficking+and+Signaling&rft.au=Porat-Shliom%2C+N%3BKloog%2C+Y%3BDonaldson%2C+J&rft.aulast=Porat-Shliom&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin V T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621688; 4739147 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hong, A AU - Toth, J AU - Sellers, J R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Drosophila+Myosin+V&rft.au=Hong%2C+A%3BToth%2C+J%3BSellers%2C+J+R&rft.aulast=Hong&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding the Biological Significance of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Internalization and Nuclear Translocation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621524; 4739063 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sivendran, R AU - Xiao, Z AU - Veenstra, T D AU - Stetler-Stevenson, W G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Translocation KW - Tissue inhibitor of metalloproteinase 2 KW - Nuclear transport KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Understanding+the+Biological+Significance+of+Tissue+Inhibitor+of+Metalloproteinase-2+%28TIMP-2%29+Internalization+and+Nuclear+Translocation&rft.au=Sivendran%2C+R%3BXiao%2C+Z%3BVeenstra%2C+T+D%3BStetler-Stevenson%2C+W+G&rft.aulast=Sivendran&rft.aufirst=R&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Myosin II-induced Maturation of Focal Adhesions T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621263; 4738993 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pasapera-Limon, A AU - Schneider, I AU - Waterman, C M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Adhesion KW - Myosin KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Analysis+of+Myosin+II-induced+Maturation+of+Focal+Adhesions&rft.au=Pasapera-Limon%2C+A%3BSchneider%2C+I%3BWaterman%2C+C+M&rft.aulast=Pasapera-Limon&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Different Erythopoietic and Immune Responses on the Outcome of Human Malaria: Insight from Numerical Studies T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620671; 4739488 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McQueen, P G AU - McKenzie, F E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Malaria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+Different+Erythopoietic+and+Immune+Responses+on+the+Outcome+of+Human+Malaria%3A+Insight+from+Numerical+Studies&rft.au=McQueen%2C+P+G%3BMcKenzie%2C+F+E&rft.aulast=McQueen&rft.aufirst=P&rft.date=2007-12-01&rft.volume=62&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SENP3 and SENP5 SUMO Proteases Regulate Ribosome Biogenesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620581; 4740888 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yun, C AU - Wang, Y AU - Mukhopadhyay, D AU - Dasso, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Ribosomes KW - Proteinase KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=SENP3+and+SENP5+SUMO+Proteases+Regulate+Ribosome+Biogenesis&rft.au=Yun%2C+C%3BWang%2C+Y%3BMukhopadhyay%2C+D%3BDasso%2C+M&rft.aulast=Yun&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Microtubules are Required for Apical Membrane Recycling in Polarized WIF-B9 Cells and Provide the "Missing Link" to the Canalcular Actin Network T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620506; 4740859 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wakabayashi, Y AU - Bourguet-Kondracki, M AU - Lippincott-Schwartz, J AU - Arias, I M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recycling KW - Waste management KW - Membranes KW - Actin KW - Microtubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Microtubules+are+Required+for+Apical+Membrane+Recycling+in+Polarized+WIF-B9+Cells+and+Provide+the+%22Missing+Link%22+to+the+Canalcular+Actin+Network&rft.au=Wakabayashi%2C+Y%3BBourguet-Kondracki%2C+M%3BLippincott-Schwartz%2C+J%3BArias%2C+I+M&rft.aulast=Wakabayashi&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Cerebellar Stellate and Basket Cells in GAD65-eGFP Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620389; 4739434 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Davis, M I AU - Hassoun, A T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Development+of+Cerebellar+Stellate+and+Basket+Cells+in+GAD65-eGFP+Mice&rft.au=Davis%2C+M+I%3BHassoun%2C+A+T&rft.aulast=Davis&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Store-operated TRPC7 Channels Function Independently of Stim1 and Orai1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619944; 4739310 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - DeHaven, W I AU - Bird, G S AU - Putney, J W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium channels KW - Orai1 protein KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Store-operated+TRPC7+Channels+Function+Independently+of+Stim1+and+Orai1&rft.au=DeHaven%2C+W+I%3BBird%2C+G+S%3BPutney%2C+J+W&rft.aulast=DeHaven&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between the Calcium Sensor Stim1 and the Ca Channel Orai1 in Activated Jurkat T Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619869; 4738734 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Barr, V A AU - Bernot, K M AU - Balagopalan, L AU - Srikanth, S AU - Gwack, Y AU - Helman, D J AU - Rao, A AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium channels KW - Sensors KW - Lymphocytes T KW - Orai1 protein KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Interactions+between+the+Calcium+Sensor+Stim1+and+the+Ca+Channel+Orai1+in+Activated+Jurkat+T+Cells&rft.au=Barr%2C+V+A%3BBernot%2C+K+M%3BBalagopalan%2C+L%3BSrikanth%2C+S%3BGwack%2C+Y%3BHelman%2C+D+J%3BRao%2C+A%3BSamelson%2C+L+E&rft.aulast=Barr&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Maternal Complex Essential for Progression Beyond the Early Cleavage Stage of Mouse Embryogenesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619385; 4740188 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Li, L. AU - Baibakokv, B AU - Dean, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Embryogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Maternal+Complex+Essential+for+Progression+Beyond+the+Early+Cleavage+Stage+of+Mouse+Embryogenesis&rft.au=Li%2C+L.%3BBaibakokv%2C+B%3BDean%2C+J&rft.aulast=Li&rft.aufirst=L.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Inhibitory Peptide (CIP) Specifically Inhibits Cdk5/p25 Activity and Regulates Insulin Secretion in Pancreatic Beta Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39618027; 4738780 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Zheng, Y AU - Hu, Y. AU - Zhang, A AU - Grant, P AU - Notkins, A AU - Pant, H C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Insulin KW - Cyclin-dependent kinase 5 KW - Secretion KW - Pancreas KW - Beta cells KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39618027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cdk5+Inhibitory+Peptide+%28CIP%29+Specifically+Inhibits+Cdk5%2Fp25+Activity+and+Regulates+Insulin+Secretion+in+Pancreatic+Beta+Cells&rft.au=Zheng%2C+Y%3BHu%2C+Y.%3BZhang%2C+A%3BGrant%2C+P%3BNotkins%2C+A%3BPant%2C+H+C&rft.aulast=Zheng&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Mechanism of Ash1 mRNA Transport by Myo4p T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39617777; 4739146 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bond, L M AU - Sellers, J R AU - Bloom, K AU - Sakamoto, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - MRNA KW - RNA transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39617777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+the+Mechanism+of+Ash1+mRNA+Transport+by+Myo4p&rft.au=Bond%2C+L+M%3BSellers%2C+J+R%3BBloom%2C+K%3BSakamoto%2C+T&rft.aulast=Bond&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Angle Neutron Scattering (SANS) Studies of Clathrin Triskelia in Solution T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39615866; 4739267 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ferguson, M L AU - Prasad, K AU - Boukari, H AU - Sackett, D L AU - Krueger, S AU - Lafer, E M AU - Nossal, R J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Clathrin KW - Neutron scattering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Small+Angle+Neutron+Scattering+%28SANS%29+Studies+of+Clathrin+Triskelia+in+Solution&rft.au=Ferguson%2C+M+L%3BPrasad%2C+K%3BBoukari%2C+H%3BSackett%2C+D+L%3BKrueger%2C+S%3BLafer%2C+E+M%3BNossal%2C+R+J&rft.aulast=Ferguson&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lamin A-dependent Misregulation of Adult Stem Cells Associated with Accelerated Aging T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39615601; 4738223 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Scaffidi, P AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Aging KW - Stem cells KW - Lamins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Lamin+A-dependent+Misregulation+of+Adult+Stem+Cells+Associated+with+Accelerated+Aging&rft.au=Scaffidi%2C+P%3BMisteli%2C+T&rft.aulast=Scaffidi&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mucolipin-1 Channel Activity is Regulated by Protein Kinase a Mediated Phosphorylation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612940; 4740142 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Vergarajauregui, S AU - Oberdick, R AU - Kiselyov, K AU - Puertollano, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Channels KW - Protein kinase A KW - Channel gating KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mucolipin-1+Channel+Activity+is+Regulated+by+Protein+Kinase+a+Mediated+Phosphorylation&rft.au=Vergarajauregui%2C+S%3BOberdick%2C+R%3BKiselyov%2C+K%3BPuertollano%2C+R&rft.aulast=Vergarajauregui&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mouse Mammary Microenvironment Redirects Spermatogenic, Neural, and Marrow Cells to a Mammary Epithelial Progenitor Cell Fate T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612777; 4738422 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Boulanger, C A AU - Booth, B W AU - Mack, D L AU - Androutsellis-Theotokis, A AU - Rosu-Myles, M AU - Wolff, L AU - McKay, R AU - Smith, G H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Microenvironments KW - Neural stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Mouse+Mammary+Microenvironment+Redirects+Spermatogenic%2C+Neural%2C+and+Marrow+Cells+to+a+Mammary+Epithelial+Progenitor+Cell+Fate&rft.au=Boulanger%2C+C+A%3BBooth%2C+B+W%3BMack%2C+D+L%3BAndroutsellis-Theotokis%2C+A%3BRosu-Myles%2C+M%3BWolff%2C+L%3BMcKay%2C+R%3BSmith%2C+G+H&rft.aulast=Boulanger&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VEGF Induces Autotaxin Expression in Ovarian Cancer and Endothelial Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612559; 4740023 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ptaszynska, M M AU - Pendrak, M L AU - Roberts, D D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Ovarian cancer KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=VEGF+Induces+Autotaxin+Expression+in+Ovarian+Cancer+and+Endothelial+Cells&rft.au=Ptaszynska%2C+M+M%3BPendrak%2C+M+L%3BRoberts%2C+D+D&rft.aulast=Ptaszynska&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concurrent Fast and Slow Cycling of a Transcriptional Activator at an Endogenous Promoter T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612011; 4738338 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Karpova, T S AU - Kim, M J AU - Spriet, C AU - Nalley, K AU - Stasevich, T AU - Kherrouche, Z AU - Heliot, L AU - McNally, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Promoters KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Concurrent+Fast+and+Slow+Cycling+of+a+Transcriptional+Activator+at+an+Endogenous+Promoter&rft.au=Karpova%2C+T+S%3BKim%2C+M+J%3BSpriet%2C+C%3BNalley%2C+K%3BStasevich%2C+T%3BKherrouche%2C+Z%3BHeliot%2C+L%3BMcNally%2C+J+G&rft.aulast=Karpova&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VEGF Controls Endothelial Cell Permeability by the Endocytosis of VE-cadherin T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611411; 4738249 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gavard, J AU - Gutkind, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Permeability KW - Endocytosis KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=VEGF+Controls+Endothelial+Cell+Permeability+by+the+Endocytosis+of+VE-cadherin&rft.au=Gavard%2C+J%3BGutkind%2C+J&rft.aulast=Gavard&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MT2-MMP Regulates Epithelial Morphogenesis and Collagen-IV Expression during Mouse Submandibular Gland Development T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611367; 4738562 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rebustini, I T AU - Myers, C AU - Surmak, A AU - Szabova, L AU - Lassiter, K AU - Holmbeck, K AU - Hoffman, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Collagen KW - Submandibular gland KW - Morphogenesis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=MT2-MMP+Regulates+Epithelial+Morphogenesis+and+Collagen-IV+Expression+during+Mouse+Submandibular+Gland+Development&rft.au=Rebustini%2C+I+T%3BMyers%2C+C%3BSurmak%2C+A%3BSzabova%2C+L%3BLassiter%2C+K%3BHolmbeck%2C+K%3BHoffman%2C+M&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endocytosis of Fluorescent Probes in the Submandibular Salivary Glands of Living Rodents: An Intra-vital Two-Photon Microscopy Study T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611072; 4738479 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Masedunskas, A AU - Weigert, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Microscopy KW - Rodents KW - Fluorescent indicators KW - Salivary gland KW - Endocytosis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Endocytosis+of+Fluorescent+Probes+in+the+Submandibular+Salivary+Glands+of+Living+Rodents%3A+An+Intra-vital+Two-Photon+Microscopy+Study&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Quantitative Scheme to Estimate Proliferation, Differentiation, and Dedifferentiation for Embryonic Stem Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39610744; 4738403 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Huang, W AU - Raaka, B M AU - Chow, C C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Cell proliferation KW - Differentiation KW - Embryo cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39610744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Quantitative+Scheme+to+Estimate+Proliferation%2C+Differentiation%2C+and+Dedifferentiation+for+Embryonic+Stem+Cells&rft.au=Huang%2C+W%3BRaaka%2C+B+M%3BChow%2C+C+C&rft.aulast=Huang&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR2 Stimulation Enhances Activation of NADPH Oxidase p47 super(phox-/-)-deficient CD8 T Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39609817; 4738736 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wanga, J A AU - Donaldson, M AU - Wood, A AU - Jackson, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - NAD(P)H oxidase KW - TLR2 protein KW - CD8 antigen KW - Lymphocytes T KW - Cell activation KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=TLR2+Stimulation+Enhances+Activation+of+NADPH+Oxidase+p47+super%28phox-%2F-%29-deficient+CD8+T+Cells&rft.au=Wanga%2C+J+A%3BDonaldson%2C+M%3BWood%2C+A%3BJackson%2C+S&rft.aulast=Wanga&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analyses of Stream Formation during Dictyostelium Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39609166; 4738595 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McCann, C P AU - Kriebel, P W AU - Rericha, E C AU - Parent, C A AU - Losert, W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Streams KW - Chemotaxis KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Quantitative+Analyses+of+Stream+Formation+during+Dictyostelium+Chemotaxis&rft.au=McCann%2C+C+P%3BKriebel%2C+P+W%3BRericha%2C+E+C%3BParent%2C+C+A%3BLosert%2C+W&rft.aulast=McCann&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kelch-related Protein Krp1 is Required for Mature Myofibril Accumulation in Cultured Mouse Cardiomyocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39608826; 4738913 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Greenberg, C C AU - Connelly, P S AU - Daniels, M P AU - Horowits, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cardiomyocytes KW - Kelch-related protein KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39608826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Kelch-related+Protein+Krp1+is+Required+for+Mature+Myofibril+Accumulation+in+Cultured+Mouse+Cardiomyocytes&rft.au=Greenberg%2C+C+C%3BConnelly%2C+P+S%3BDaniels%2C+M+P%3BHorowits%2C+R&rft.aulast=Greenberg&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syntabulin-KIF5B-mediated Axonal Transport Contributes to Activity-dependent Presynaptic Assembly T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39605350; 4739449 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Cai, Q AU - Pan, P AU - Sheng, Z Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Axonal transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Syntabulin-KIF5B-mediated+Axonal+Transport+Contributes+to+Activity-dependent+Presynaptic+Assembly&rft.au=Cai%2C+Q%3BPan%2C+P%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation and Targeting of Extracellular Hydrogen Peroxide Generators, Duox1 and Duox2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39604603; 4740312 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Morand, S C AU - Leto, T L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Hydrogen peroxide KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Maturation+and+Targeting+of+Extracellular+Hydrogen+Peroxide+Generators%2C+Duox1+and+Duox2&rft.au=Morand%2C+S+C%3BLeto%2C+T+L&rft.aulast=Morand&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acanthamoeba Myosin IC and PIP2 Colocalize In Vivo T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39602647; 4739860 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Brzeska, H AU - Korn, E D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Phosphatidylinositol 4,5-diphosphate KW - Acanthamoeba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Use+of+mental+health+services+for+anxiety%2C+mood%2C+and+substance+disorders+in+17+countries+in+the+WHO+world+mental+health+surveys.&rft.au=Wang%2C+Philip+S%3BAguilar-Gaxiola%2C+Sergio%3BAlonso%2C+Jordi%3BAngermeyer%2C+Matthias+C%3BBorges%2C+Guilherme%3BBromet%2C+Evelyn+J%3BBruffaerts%2C+Ronny%3Bde+Girolamo%2C+Giovanni%3Bde+Graaf%2C+Ron%3BGureje%2C+Oye%3BHaro%2C+Josep+Maria%3BKaram%2C+Elie+G%3BKessler%2C+Ronald+C%3BKovess%2C+Viviane%3BLane%2C+Michael+C%3BLee%2C+Sing%3BLevinson%2C+Daphna%3BOno%2C+Yutaka%3BPetukhova%2C+Maria%3BPosada-Villa%2C+Jos%C3%A9%3BSeedat%2C+Soraya%3BWells%2C+J+Elisabeth&rft.aulast=Wang&rft.aufirst=Philip&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Damage is not Required for the Action of DNA Damage Response Pathways T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39602575; 4739825 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Soutoglou, E AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=DNA+Damage+is+not+Required+for+the+Action+of+DNA+Damage+Response+Pathways&rft.au=Soutoglou%2C+E%3BMisteli%2C+T&rft.aulast=Soutoglou&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutive Trafficking of G-Protein Coupled Receptors T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39597078; 4738469 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Scarselli, M AU - Donaldson, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - G protein-coupled receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39597078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Constitutive+Trafficking+of+G-Protein+Coupled+Receptors&rft.au=Scarselli%2C+M%3BDonaldson%2C+J+G&rft.aulast=Scarselli&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p47phox-deficient Dendritic Cells Enhance Antigen-specific T Cell Proliferation and IFN-g Secretion T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39593236; 4740007 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Jendrysik, M A AU - Zhu, N AU - Wood, A AU - Changpriroa, C AU - Jackson, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell proliferation KW - G-Interferon KW - Dendritic cells KW - Lymphocytes T KW - Secretion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=p47phox-deficient+Dendritic+Cells+Enhance+Antigen-specific+T+Cell+Proliferation+and+IFN-g+Secretion&rft.au=Jendrysik%2C+M+A%3BZhu%2C+N%3BWood%2C+A%3BChangpriroa%2C+C%3BJackson%2C+S&rft.aulast=Jendrysik&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Molecular Mechanism for Aging-related Loss of Heterochromatin and DNA Damage T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39592393; 4740568 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pegoraro, G AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Heterochromatin KW - Molecular modelling KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39592393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Molecular+Mechanism+for+Aging-related+Loss+of+Heterochromatin+and+DNA+Damage&rft.au=Pegoraro%2C+G%3BMisteli%2C+T&rft.aulast=Pegoraro&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Search of ECM: Live-Cell Imaging of Micro-patterned Substrata T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39590744; 4739580 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Doyle, A D AU - Wang, F W AU - Yamada, K M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Imaging techniques KW - Extracellular matrix KW - Substrata KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39590744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=In+Search+of+ECM%3A+Live-Cell+Imaging+of+Micro-patterned+Substrata&rft.au=Doyle%2C+A+D%3BWang%2C+F+W%3BYamada%2C+K+M&rft.aulast=Doyle&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Protein+Discovery+and+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extensibility of Coiled-Coil Regions of Processive and Nonprocessive Myosin V Molecules T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39589394; 4739144 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Nagy, A AU - Sellers, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39589394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Extensibility+of+Coiled-Coil+Regions+of+Processive+and+Nonprocessive+Myosin+V+Molecules&rft.au=Nagy%2C+A%3BSellers%2C+J&rft.aulast=Nagy&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of O-GlcNAcase on Insulin Signaling in Adipocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39588727; 4739038 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Keembiyehetty, C N AU - Kim, E J AU - Love, D C AU - Hanover, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Insulin KW - Signal transduction KW - Adipocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39588727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+O-GlcNAcase+on+Insulin+Signaling+in+Adipocytes&rft.au=Keembiyehetty%2C+C+N%3BKim%2C+E+J%3BLove%2C+D+C%3BHanover%2C+J&rft.aulast=Keembiyehetty&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear Envelope Assembly by Fusion between Nuclear Membrane Vesicles and Protein-free Liposomes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39587626; 4740895 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rafikova, E AU - Ramos, C AU - Melikov, K AU - Dye, L AU - Chernomordik, L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39587626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Nuclear+Envelope+Assembly+by+Fusion+between+Nuclear+Membrane+Vesicles+and+Protein-free+Liposomes&rft.au=Rafikova%2C+E%3BRamos%2C+C%3BMelikov%2C+K%3BDye%2C+L%3BChernomordik%2C+L&rft.aulast=Rafikova&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pseudomonas aeruginosa Pigment Pyocyanin Inhibits the Dual Oxidase-mediated Antimicrobial Defense System in Human Airways T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39586422; 4739503 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rada, B AU - Lekstrom, K AU - Leto, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pigments KW - Antimicrobial agents KW - Pyocyanin KW - Respiratory tract KW - Pseudomonas aeruginosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39586422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Pseudomonas+aeruginosa+Pigment+Pyocyanin+Inhibits+the+Dual+Oxidase-mediated+Antimicrobial+Defense+System+in+Human+Airways&rft.au=Rada%2C+B%3BLekstrom%2C+K%3BLeto%2C+T&rft.aulast=Rada&rft.aufirst=B&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PGC1a Induces Chromatin Structure Changes at the MHRE Region of the ERRa Gene T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39585444; 4739413 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wang, L AU - Hu, P. AU - Teng, C T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39585444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=PGC1a+Induces+Chromatin+Structure+Changes+at+the+MHRE+Region+of+the+ERRa+Gene&rft.au=Wang%2C+L%3BHu%2C+P.%3BTeng%2C+C+T&rft.aulast=Wang&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The High Mobility Group Box Transcription Factor Nhp6Ap Enters the Nucleus by a Calmodulin-dependent, Ran-independent Pathway T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39585304; 4740137 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hanover, J AU - O'Kane, M AU - Love, D AU - Yen, Y AU - Johnson, R AU - Prinz, W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mobility KW - Nuclei KW - High mobility group proteins KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39585304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+High+Mobility+Group+Box+Transcription+Factor+Nhp6Ap+Enters+the+Nucleus+by+a+Calmodulin-dependent%2C+Ran-independent+Pathway&rft.au=Hanover%2C+J%3BO%27Kane%2C+M%3BLove%2C+D%3BYen%2C+Y%3BJohnson%2C+R%3BPrinz%2C+W&rft.aulast=Hanover&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Point Mutation in Nonmuscle Myosin II-C is Associated with a Novel Lymphoproliferative Disease T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39584178; 4740470 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kim, K Y AU - Shin, D AU - Morse, H C AU - Snow, A AU - Lenardo, M J AU - Hwang, I Y AU - Park, C AU - Kehrl, J H AU - Brinster, L R AU - Zerfas, P AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Point mutation KW - Immunoproliferative diseases KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Point+Mutation+in+Nonmuscle+Myosin+II-C+is+Associated+with+a+Novel+Lymphoproliferative+Disease&rft.au=Kim%2C+K+Y%3BShin%2C+D%3BMorse%2C+H+C%3BSnow%2C+A%3BLenardo%2C+M+J%3BHwang%2C+I+Y%3BPark%2C+C%3BKehrl%2C+J+H%3BBrinster%2C+L+R%3BZerfas%2C+P%3BAdelstein%2C+R+S&rft.aulast=Kim&rft.aufirst=K&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carboxypeptidase E Recruits Microtubule Motors to Peptidergic Vesicles for Post-Golgi Trafficking to the Release Site T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583912; 4740244 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Park, J J AU - Loh, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recruitment KW - Microtubules KW - Vesicles KW - Carboxypeptidase E KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Carboxypeptidase+E+Recruits+Microtubule+Motors+to+Peptidergic+Vesicles+for+Post-Golgi+Trafficking+to+the+Release+Site&rft.au=Park%2C+J+J%3BLoh%2C+Y&rft.aulast=Park&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatin Reorganization in Response to Migration Cues T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583758; 4740430 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gerlitz, G AU - Livnat, I AU - Ziv, C AU - Yarden, O AU - Reiner, O AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Migration KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Chromatin+Reorganization+in+Response+to+Migration+Cues&rft.au=Gerlitz%2C+G%3BLivnat%2C+I%3BZiv%2C+C%3BYarden%2C+O%3BReiner%2C+O%3BBustin%2C+M&rft.aulast=Gerlitz&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mast Cells Possess Distinct Secretory Granule Subsets Whose Exocytosis is Regulated by Different SNARE Isoforms T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583591; 4740831 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Puri, N AU - Roche, P A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mast cells KW - SNAP receptors KW - Exocytosis KW - Secretory vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mast+Cells+Possess+Distinct+Secretory+Granule+Subsets+Whose+Exocytosis+is+Regulated+by+Different+SNARE+Isoforms&rft.au=Puri%2C+N%3BRoche%2C+P+A&rft.aulast=Puri&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Nonmuscle Myosin II in Mouse Heart Development T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583392; 4740475 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ma, X. AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Role+of+Nonmuscle+Myosin+II+in+Mouse+Heart+Development&rft.au=Ma%2C+X.%3BAdelstein%2C+R+S&rft.aulast=Ma&rft.aufirst=X.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cbl-dependent Regulation of LAT-nucleated Signaling Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582675; 4738737 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Balagopalan, L AU - Barr, V A AU - Sommers, C L AU - Barda-Saad, M AU - Goyal, A AU - Isakowitz, M E AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cbl-dependent+Regulation+of+LAT-nucleated+Signaling+Complexes&rft.au=Balagopalan%2C+L%3BBarr%2C+V+A%3BSommers%2C+C+L%3BBarda-Saad%2C+M%3BGoyal%2C+A%3BIsakowitz%2C+M+E%3BSamelson%2C+L+E&rft.aulast=Balagopalan&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiogenesis Inhibition by Semaphorin 3E T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582404; 4740070 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sakurai, A AU - Gavard, J AU - Basile, J R AU - Annas-Linhares, Y AU - Gutkind, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Semaphorins KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Angiogenesis+Inhibition+by+Semaphorin+3E&rft.au=Sakurai%2C+A%3BGavard%2C+J%3BBasile%2C+J+R%3BAnnas-Linhares%2C+Y%3BGutkind%2C+J&rft.aulast=Sakurai&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SZY-20, a Novel RNA-Binding Protein, Limits Centrosome Size T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39581400; 4738800 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Song, M AU - Iyer, A AU - O'Connell, K F Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - RNA-binding protein KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=SZY-20%2C+a+Novel+RNA-Binding+Protein%2C+Limits+Centrosome+Size&rft.au=Song%2C+M%3BIyer%2C+A%3BO%27Connell%2C+K+F&rft.aulast=Song&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of RNA Polymerase I Transcription in Response to DNA Breaks is ATM-dependent T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39580737; 4738302 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kruhlak, M AU - Crouch, E AU - Orlov, M AU - Montano, C AU - Gorski, S AU - Nussenzweig, A AU - Misteli, T AU - Robert, P AU - Casellas, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Transcription KW - DNA-directed RNA polymerase KW - DNA damage KW - Nucleic acids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Inhibition+of+RNA+Polymerase+I+Transcription+in+Response+to+DNA+Breaks+is+ATM-dependent&rft.au=Kruhlak%2C+M%3BCrouch%2C+E%3BOrlov%2C+M%3BMontano%2C+C%3BGorski%2C+S%3BNussenzweig%2C+A%3BMisteli%2C+T%3BRobert%2C+P%3BCasellas%2C+R&rft.aulast=Kruhlak&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proper Expression of Epidermal Stratification Markers Requires Down-regulation of High Mobility Group Nucleosome (HMGN) Proteins Expression T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39580525; 4738256 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Furusawa, T AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stratification KW - Mobility KW - Nucleosomes KW - High mobility group proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Proper+Expression+of+Epidermal+Stratification+Markers+Requires+Down-regulation+of+High+Mobility+Group+Nucleosome+%28HMGN%29+Proteins+Expression&rft.au=Furusawa%2C+T%3BBustin%2C+M&rft.aulast=Furusawa&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Connexin43 Modulates Polarized Cell Morphology and Directional Cell Migration through Tubulin Interaction and the Assembly of Stabilized Microtubules T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39579788; 4739302 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Francis, R J B AU - Xu, X. AU - Park, K AU - Wei, C AU - Chang, S AU - Alaei, S AU - Charterjee, B AU - Bulinsky, C AU - Lo, C W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell morphology KW - Tubulin KW - Connexin 43 KW - Microtubules KW - Cell migration KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Connexin43+Modulates+Polarized+Cell+Morphology+and+Directional+Cell+Migration+through+Tubulin+Interaction+and+the+Assembly+of+Stabilized+Microtubules&rft.au=Francis%2C+R+J+B%3BXu%2C+X.%3BPark%2C+K%3BWei%2C+C%3BChang%2C+S%3BAlaei%2C+S%3BCharterjee%2C+B%3BBulinsky%2C+C%3BLo%2C+C+W&rft.aulast=Francis&rft.aufirst=R+J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Diaspartate Motif is Required for Direct Binding of HIV Nef to the Clathrin Adaptor Complex AP2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39579573; 4739269 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lindwasser, W AU - Smith, W J AU - Chaudhuri, R AU - Yang, P AU - Hurley, J H AU - Bonifacino, J S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Human immunodeficiency virus KW - Clathrin KW - Nef protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Diaspartate+Motif+is+Required+for+Direct+Binding+of+HIV+Nef+to+the+Clathrin+Adaptor+Complex+AP2&rft.au=Lindwasser%2C+W%3BSmith%2C+W+J%3BChaudhuri%2C+R%3BYang%2C+P%3BHurley%2C+J+H%3BBonifacino%2C+J+S&rft.aulast=Lindwasser&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apq12p: A Novel Cell Cycle Regulator in Saccharomyces cerevisiae T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39578262; 4738804 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fearon, P AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell cycle KW - Saccharomyces cerevisiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Apq12p%3A+A+Novel+Cell+Cycle+Regulator+in+Saccharomyces+cerevisiae&rft.au=Fearon%2C+P%3BCohen-Fix%2C+O&rft.aulast=Fearon&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Identification of Esp1p Regulators Using a Suppressor Screen T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39578226; 4738798 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Barbour, L AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Identification+of+Esp1p+Regulators+Using+a+Suppressor+Screen&rft.au=Barbour%2C+L%3BCohen-Fix%2C+O&rft.aulast=Barbour&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Branching Morphogenesis of Endothelial Cells is Regulated by Myosin Contractility T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39577693; 4738556 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fischer, R S AU - Gardel, M AU - Waterman, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Endothelial cells KW - Contractility KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Branching+Morphogenesis+of+Endothelial+Cells+is+Regulated+by+Myosin+Contractility&rft.au=Fischer%2C+R+S%3BGardel%2C+M%3BWaterman%2C+C&rft.aulast=Fischer&rft.aufirst=R&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple b1 Integrin Cytoplasmic Domain Single Site Mutations Modulate Fibronectin Fibrillogenesis and Integrin Function T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39574434; 4739962 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Green, J A AU - Berrier, A AU - Pankov, R AU - Yamada, K M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mutation KW - Integrins KW - Fibrillogenesis KW - Fibronectin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39574434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Multiple+b1+Integrin+Cytoplasmic+Domain+Single+Site+Mutations+Modulate+Fibronectin+Fibrillogenesis+and+Integrin+Function&rft.au=Green%2C+J+A%3BBerrier%2C+A%3BPankov%2C+R%3BYamada%2C+K+M&rft.aulast=Green&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired Embryonic Stem Cell Differentiation by Aberrant Expression of the Nucleosome Binding Protein HMGN1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39569131; 4738412 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Cherukuri, S AU - Rand, E AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Nucleosomes KW - Differentiation KW - Embryo cells KW - Cell differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39569131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Impaired+Embryonic+Stem+Cell+Differentiation+by+Aberrant+Expression+of+the+Nucleosome+Binding+Protein+HMGN1&rft.au=Cherukuri%2C+S%3BRand%2C+E%3BBustin%2C+M&rft.aulast=Cherukuri&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Regulation of Centriole Replication in C. elegans T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39538182; 4740749 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Peters, N Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Replication KW - Centrioles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39538182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Developmental+Regulation+of+Centriole+Replication+in+C.+elegans&rft.au=Peters%2C+N&rft.aulast=Peters&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opposing Roles for Gab2 and Gab3 in M-CSF-mediated Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39537595; 4740615 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Vedham, V AU - Hall, A B AU - Brugge, J S AU - Coggeshall, K Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Opposing+Roles+for+Gab2+and+Gab3+in+M-CSF-mediated+Chemotaxis&rft.au=Vedham%2C+V%3BHall%2C+A+B%3BBrugge%2C+J+S%3BCoggeshall%2C+K&rft.aulast=Vedham&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NSBP1: A Novel Protein Which Binds Specifically to Nucleosome in Euchromatin and Affects Cellular Differentiation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39537477; 4740571 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rochman, M AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Euchromatin KW - Nucleosomes KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=NSBP1%3A+A+Novel+Protein+Which+Binds+Specifically+to+Nucleosome+in+Euchromatin+and+Affects+Cellular+Differentiation&rft.au=Rochman%2C+M%3BBustin%2C+M&rft.aulast=Rochman&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Nonmuscle Myosin IIB and N-RAP in Regulation of Cell Spreading and Myofibril Assembly in Primary Mouse Cardiomyocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39535739; 4738912 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lu, S. AU - Horowits, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cardiomyocytes KW - Myosin KW - Myofibrils KW - Cell spreading KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39535739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Role+of+Nonmuscle+Myosin+IIB+and+N-RAP+in+Regulation+of+Cell+Spreading+and+Myofibril+Assembly+in+Primary+Mouse+Cardiomyocytes&rft.au=Lu%2C+S.%3BHorowits%2C+R&rft.aulast=Lu&rft.aufirst=S.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cleavage Status of ZP2 Determines Initial Sperm-Egg Recognition in Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39534632; 4740898 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gahlay, G K AU - Dean, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cleavage+Status+of+ZP2+Determines+Initial+Sperm-Egg+Recognition+in+Mice&rft.au=Gahlay%2C+G+K%3BDean%2C+J&rft.aulast=Gahlay&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Intracellular Phosphatidylserine in Living Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39534552; 4740830 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Calderon, F AU - Kim, H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Phosphatidylserine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Detection+of+Intracellular+Phosphatidylserine+in+Living+Cells&rft.au=Calderon%2C+F%3BKim%2C+H&rft.aulast=Calderon&rft.aufirst=F&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ML-9 Inhibits Store-operated Calcium Entry by Reversing Store Depletion-induced Stim1 Rearrangement T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39533952; 4739309 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Smyth, J T AU - DeHaven, W I AU - Bird, G S AU - Putney, J W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=ML-9+Inhibits+Store-operated+Calcium+Entry+by+Reversing+Store+Depletion-induced+Stim1+Rearrangement&rft.au=Smyth%2C+J+T%3BDeHaven%2C+W+I%3BBird%2C+G+S%3BPutney%2C+J+W&rft.aulast=Smyth&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of GAK (auxilin-2) in Developing and Mature Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39533848; 4739279 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yim, Y AU - Lee, D AU - Eisenberg, E AU - Greene, L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Essential+Role+of+GAK+%28auxilin-2%29+in+Developing+and+Mature+Mice&rft.au=Yim%2C+Y%3BLee%2C+D%3BEisenberg%2C+E%3BGreene%2C+L&rft.aulast=Yim&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Keeps the Yeast Nucleus Hanging Round?: Methods to Identify Genes that Maintain Nuclear Structure in S. cerevisiae T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39532668; 4739420 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Webster, M T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39532668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=What+Keeps+the+Yeast+Nucleus+Hanging+Round%3F%3A+Methods+to+Identify+Genes+that+Maintain+Nuclear+Structure+in+S.+cerevisiae&rft.au=Webster%2C+M+T&rft.aulast=Webster&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Embryonic Stem Cell DNA Methylation Modulates the Interaction of Nucleosome-binding Proteins with Chromatin T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39532555; 4739407 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rand, E AU - Meshorer, E AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Chromatin KW - DNA methylation KW - Embryo cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39532555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Embryonic+Stem+Cell+DNA+Methylation+Modulates+the+Interaction+of+Nucleosome-binding+Proteins+with+Chromatin&rft.au=Rand%2C+E%3BMeshorer%2C+E%3BBustin%2C+M&rft.aulast=Rand&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Transmembrane Protein, CBP, Responsible for Transiently Anchoring Small Clusters of Thy-1, a GPI-anchored Protein, to the Cytoskeleton T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39531707; 4740238 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chen, Y AU - Benistant, C AU - Jacobsona, K Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cytoskeleton KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Identification+of+a+Transmembrane+Protein%2C+CBP%2C+Responsible+for+Transiently+Anchoring+Small+Clusters+of+Thy-1%2C+a+GPI-anchored+Protein%2C+to+the+Cytoskeleton&rft.au=Chen%2C+Y%3BBenistant%2C+C%3BJacobsona%2C+K&rft.aulast=Chen&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The C-terminal Extension of hCenexin1 Is Critical for Proper Recruitment and Mitotic Functions of Mammalian Polo-like Kinase 1 (Plk1) at the Centrosomes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39528343; 4738201 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Soung, N AU - Yu, L. AU - Veenstra, T AU - Lee, K S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recruitment KW - Polo-like kinase 1 KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39528343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+C-terminal+Extension+of+hCenexin1+Is+Critical+for+Proper+Recruitment+and+Mitotic+Functions+of+Mammalian+Polo-like+Kinase+1+%28Plk1%29+at+the+Centrosomes&rft.au=Soung%2C+N%3BYu%2C+L.%3BVeenstra%2C+T%3BLee%2C+K+S&rft.aulast=Soung&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Empirical likelihood-based inference for genetic mixture models AN - 36978225; 3774857 JF - Canadian journal of statistics AU - Huang, Chiung-Yu AU - Qin, Jing AU - Zou, Fei AD - US National Institutes of Health, Bethesda ; University of North Carolina Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 563 EP - 574 VL - 35 IS - 4 SN - 0319-5724, 0319-5724 KW - Economics KW - Statistical models KW - Significance tests KW - Estimation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36978225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Empirical+likelihood-based+inference+for+genetic+mixture+models&rft.au=Huang%2C+Chiung-Yu%3BQin%2C+Jing%3BZou%2C+Fei&rft.aulast=Huang&rft.aufirst=Chiung-Yu&rft.date=2007-12-01&rft.volume=35&rft.issue=4&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+statistics&rft.issn=03195724&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 4403 7854; 11658 12224 971 ER - TY - JOUR T1 - Physicians' access to ethics support services in four European countries AN - 36923805; 3565291 AB - Clinical ethics support services are developing in Europe. They will be most useful if they are designed to match the ethical concern of clinicians. We conducted a cross-sectional mailed survey on random samples of general physicians in Norway, Switzerland, Italy, and the UK, to assess their access to different types of ethics support services, and to describe what makes them more likely to have used available ethics support. Respondents reported access to formal ethics support services such as clinical ethics committees (23%), consultation in individual cases (17.6%), and individual ethicists (8.8%), but also to other kinds of less formal ethics support (23.6%). Access to formal ethics support services was associated with work in urban hospitals. Informal ethics resources were more evenly distributed. Although most respondents (81%) reported that they would find help useful in Reprinted by permission of Springer JF - Health care analysis AU - Hurst, Samia A AU - Reiter-Theil, Stella AU - Perrier, Arnaud AU - Forde, Reidun AU - Slowther, Anne-Marie AU - Pegoraro, Renzo AU - Danis, Marion AD - Université de Genève ; Universität Basel ; Hôpitaux Universitaires de Genève ; Norwegian Medical Association ; University of Oxford ; Fondazione Lanza, Padova ; National Institutes of Health, Bethesda Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 321 EP - 335 VL - 15 IS - 4 SN - 1065-3058, 1065-3058 KW - Political Science KW - Sociology KW - Access to services KW - Comparative analysis KW - Social support KW - Doctors KW - Survey data KW - Medical ethics KW - Hospital services KW - Norway KW - Italy KW - Switzerland KW - United Kingdom KW - Cross-national analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36923805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+analysis&rft.atitle=Physicians%27+access+to+ethics+support+services+in+four+European+countries&rft.au=Hurst%2C+Samia+A%3BReiter-Theil%2C+Stella%3BPerrier%2C+Arnaud%3BForde%2C+Reidun%3BSlowther%2C+Anne-Marie%3BPegoraro%2C+Renzo%3BDanis%2C+Marion&rft.aulast=Hurst&rft.aufirst=Samia&rft.date=2007-12-01&rft.volume=15&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Health+care+analysis&rft.issn=10653058&rft_id=info:doi/10.1007%2Fs10728-007-0072-6 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3675 10299 13682 7883 8864; 7879 4408 8282 8281 6085; 3060 971; 11938 11949 13521; 12427 12429; 6008 5792 10484; 2630 971; 438 462 129 302; 306 302 129 370; 408 462 129; 188 396 129 DO - http://dx.doi.org/10.1007/s10728-007-0072-6 ER - TY - JOUR T1 - Self-administration of drugs in animals and humans as a model and an investigative tool AN - 36826737; 3516019 AB - Aims To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self-administration in animals and humans. Background The use of drug self-administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self-administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre-clinical research that also involves screening with a variety of simpler behavioral techniques, drug self-administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self-administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self-administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Panlilio, Leigh V AU - Goldberg, Steven R AD - US National Institute on Drug Abuse Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1863 EP - 1870 VL - 102 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Medical research KW - Drug abuse KW - Self-management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36826737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Self-administration+of+drugs+in+animals+and+humans+as+a+model+and+an+investigative+tool&rft.au=Panlilio%2C+Leigh+V%3BGoldberg%2C+Steven+R&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-12-01&rft.volume=102&rft.issue=12&rft.spage=1863&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02011.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7886 10902; 3742 1121 11776 3753 3755; 11480 7625 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02011.x ER - TY - JOUR T1 - Incorporating historical control data when comparing tumor incidence rates AN - 36819949; 3510623 JF - Journal of the American Statistical Association AU - Peddada, Shyamal D AU - Dinse, Gregg E AU - Kissling, Grace E AD - National Institute of Environmental Health Sciences Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1212 EP - 1220 VL - 102 IS - 480 SN - 0162-1459, 0162-1459 KW - Anthropology KW - Medical care KW - Statistical analysis KW - Survival KW - Toxicity KW - Statistical methods KW - Cancer KW - Bayesian method KW - Methodology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36819949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Incorporating+historical+control+data+when+comparing+tumor+incidence+rates&rft.au=Peddada%2C+Shyamal+D%3BDinse%2C+Gregg+E%3BKissling%2C+Grace+E&rft.aulast=Peddada&rft.aufirst=Shyamal&rft.date=2007-12-01&rft.volume=102&rft.issue=480&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214506000001356 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 1939 3617 6220; 7875 5775 13521; 10449 5772; 12430; 7994; 12807 9818; 1512 3865 4025 DO - http://dx.doi.org/10.1198/016214506000001356 ER - TY - JOUR T1 - New directions in race research AN - 36816697; 3510923 JF - Social forces AU - Lee, Jennifer AU - Bean, Frank D AU - Hitlin, Steven AU - Brown, J Scott AU - Elder Jr, Glen H AU - Croll, Paul R AU - Hochschild, Jennifer L AU - Weaver, Vesla AU - Bond, Carolyn AU - Williams, Richard AU - Krysan, Maria AU - Bader, Michael AU - Marsh, Kris AU - Darity, Jr., William A. AU - Cohen, Philip N AU - Casper, Lynne M AU - Salters, Danielle AU - Sarkisian, Natalia AU - Phillips, Elizabeth M AU - Odunlami, Adebola O AU - Bonham, Vence L AU - Bratter, Jenifer AD - University of California, Irvine ; University of Iowa ; Miami University ; University of North Carolina, Chapel Hill ; University of Minnesota ; Harvard University ; University of Virginia ; West Chester University ; University of Notre Dame ; University of Illinois, Chicago ; University of Michigan ; Duke University ; University of Southern California ; Boston College ; National Human Genome Research Institute ; Rice University Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 553 EP - 850 VL - 86 IS - 2 SN - 0037-7732, 0037-7732 KW - Sociology KW - Detroit KW - Masculinity KW - Multiculturalism KW - Socioeconomic status KW - Blacks KW - Parent-child relations KW - Urban sociology KW - Social change KW - Self KW - Property KW - Social norms KW - Race relations KW - Genetics KW - Cities KW - Colour KW - Classification KW - Diseases KW - Community KW - Social psychology KW - Immigration KW - Identity politics KW - Ethnicity KW - Social systems KW - Organization theory KW - Discrimination KW - Marriage KW - U.S.A. KW - Children KW - Professionalization KW - Social inequality KW - Identity KW - Social values KW - African-Americans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+forces&rft.atitle=New+directions+in+race+research&rft.au=Lee%2C+Jennifer%3BBean%2C+Frank+D%3BHitlin%2C+Steven%3BBrown%2C+J+Scott%3BElder+Jr%2C+Glen+H%3BCroll%2C+Paul+R%3BHochschild%2C+Jennifer+L%3BWeaver%2C+Vesla%3BBond%2C+Carolyn%3BWilliams%2C+Richard%3BKrysan%2C+Maria%3BBader%2C+Michael%3BMarsh%2C+Kris%3BDarity%2C+Jr.%2C+William+A.%3BCohen%2C+Philip+N%3BCasper%2C+Lynne+M%3BSalters%2C+Danielle%3BSarkisian%2C+Natalia%3BPhillips%2C+Elizabeth+M%3BOdunlami%2C+Adebola+O%3BBonham%2C+Vence+L%3BBratter%2C+Jenifer&rft.aulast=Lee&rft.aufirst=Jennifer&rft.date=2007-12-01&rft.volume=86&rft.issue=2&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Social+forces&rft.issn=00377732&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 10 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10558 6093; 4435; 11442 6191; 6191; 6233 8040; 11783; 2360 2688 2449 10404; 6197 9809; 11901 10404; 11942; 11875 11979; 11948 13245 8281 6085; 2509 13338 3198; 3612 3549 2688 2449 10404; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 10339; 11853 6489; 13194 12008; 2603; 635 1656 10555 6091 961 636 4424; 2274 13161 1247; 1656 10555 6091; 7748 6823; 10301; 7782 5421 6091; 9012; 3617 6220; 5460 1615 8573 11325; 2212; 8346 3127 3121 3198 3549 2688 2449 10404; 9178 4777 6093 6823; 433 293 14 ER - TY - JOUR T1 - Bayesian multivariate isotonic regression splines: applications to carcinogenicity studies AN - 36816256; 3510619 JF - Journal of the American Statistical Association AU - Cai, Bo AU - Dunson, David B AD - University of South Carolina ; National Institute of Environmental Health Sciences Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1158 EP - 1171 VL - 102 IS - 480 SN - 0162-1459, 0162-1459 KW - Anthropology KW - Model testing KW - Multivariate analysis KW - Medical research KW - Regression analysis KW - Statistical analysis KW - Data analysis KW - Statistical methods KW - Cancer KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Bayesian+multivariate+isotonic+regression+splines%3A+applications+to+carcinogenicity+studies&rft.au=Cai%2C+Bo%3BDunson%2C+David+B&rft.aulast=Cai&rft.aufirst=Bo&rft.date=2007-12-01&rft.volume=102&rft.issue=480&rft.spage=1158&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214506000000942 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 1512 3865 4025; 8379 12224 971; 10739 12228 10919; 1939 3617 6220; 8160 8163; 3279 971 3286; 7886 10902 DO - http://dx.doi.org/10.1198/016214506000000942 ER - TY - JOUR T1 - Monitoring rare serious adverse events from a new treatment and testing for a difference from historical controls AN - 21331622; 10898611 AB - Background We detail the design of a study to monitor the safety of including albendazole to an existing treatment regimen to eliminate lymphatic filariasis. We wish to show that this new regimen does not increase the rate of a rare serious adverse event (SAE) compared to the old regimen. Controlled but small clinical trials have not detected any increase in the SAE using albendazole, and it is known to have added benefits; therefore, it is unethical to randomize patients to the old regimen.Purpose A sample size for the new regimen is needed to test that the new rate of SAE is noninferior to the historic rate. If the new regimen does have an inferior rate of SAE then we wish to stop the study early. This setup is different from traditional early stopping for efficacy and futility. In that traditional case, the two stopping decisions are relative to the same null hypothesis of equality, while in our setup, we have two different null hypotheses: the noninferiority null and the equality null. When testing the former, we need not stop early if the new regimen appears better because no subjects are receiving the old regimen anymore anyway. When testing the equality of SAE rates, however, we want to stop early if the new regimen has a significantly higher rate of SAE.Methods We create a design that uses an exact difference in proportions test for testing noninferiority, but calculates maximal sample size based on conditional power which treats the historical rates as true rates. The design allows for early stopping if the new treatment appears inferior with respect to SAE rate but makes no corrections for multiple testing. We explore the properties of this naive design without assuming the historical rates are known.Results For our example, we show that our naive design strategy bounds the type I error of the noninferiority hypothesis in all cases and bounds it for the equality hypothesis at 0.05, as long as the true SAE rate is <0.00015. The same design has unconditional power for the noninferiority hypothesis greater than the nominal 80% as long as the true SAE rate for both regimens are <0.00025.Limitations The type I and power results above hold only for our historical sample size of 17 877. We expect similar type I and power properties to hold with studies with SAE rates similar or less (i.e., < 0.00015) and historical sample sizes similar or smaller.Conclusions Our design for comparing very rare historical SAE rates to SAE rates of a new treatment has large power to conclude noninferiority of the new treatment SAE rate when both rates are equal, but allows early stopping if the new SAE rates are worse. Clinical Trials 2007; 4: 598-610. http://ctj.sagepub.com JF - Clinical Trials AU - Fay, Michael P AU - Huang, Chiung-Yu AU - Twum-Danso, Nana AY AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892-7609, USA, mfay@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 598 EP - 610 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 4 IS - 6 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts KW - Historical account KW - safety engineering KW - Medical treatment KW - clinical trials KW - Side effects KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21331622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Monitoring+rare+serious+adverse+events+from+a+new+treatment+and+testing+for+a+difference+from+historical+controls&rft.au=Fay%2C+Michael+P%3BHuang%2C+Chiung-Yu%3BTwum-Danso%2C+Nana+AY&rft.aulast=Fay&rft.aufirst=Michael&rft.date=2007-12-01&rft.volume=4&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774507084978 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Medical treatment; Historical account; clinical trials; Side effects; safety engineering DO - http://dx.doi.org/10.1177/1740774507084978 ER - TY - JOUR T1 - Cholesterol Ester Storage Disease With Unusual Neurological Manifestations in Two Siblings: A Report From South India AN - 21206144; 11650183 AB - Cholesterol ester storage disease is a rare autosomal recessive storage disorder resulting from lysosomal acid lipase deficiency. Two siblings manifested with hepatosplenomegaly, ptosis, and bilateral external ophthalmoplegia. Evaluation revealed hyperlipidemia and bilateral adrenal calcifications. Leukocyte acid lipase levels were significantly low in both the patients, compared with controls, suggesting a diagnosis of cholesterol ester storage disease. Ptosis and external ophthalmoplegia have hitherto not been reported in cholesterol ester storage disease. JF - Journal of Child Neurology AU - Bindu, P S AU - Taly, AB AU - Christopher, R AU - BharatKumar, P V AU - Panda, S AU - Netravathi, M AU - Ravishankar, S AU - Mahadevan, A AU - Yasha, T C AU - Gayathri, N AD - Department of Neuropathology National Institute of Mental Health & Neurosciences, Bangalore, India Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1401 EP - 1404 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 22 IS - 12 SN - 0883-0738, 0883-0738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - acid lipase KW - cholesterol ester storage disease KW - ophthalmoplegia KW - ptosis KW - Wolman disease KW - Triacylglycerol lipase KW - storage diseases KW - Calcification KW - Hereditary diseases KW - Hyperlipidemia KW - Leukocytes KW - Siblings KW - Cholesterol KW - Esters KW - Ophthalmoplegia KW - A 01490:Miscellaneous KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Neurology&rft.atitle=Cholesterol+Ester+Storage+Disease+With+Unusual+Neurological+Manifestations+in+Two+Siblings%3A+A+Report+From+South+India&rft.au=Bindu%2C+P+S%3BTaly%2C+AB%3BChristopher%2C+R%3BBharatKumar%2C+P+V%3BPanda%2C+S%3BNetravathi%2C+M%3BRavishankar%2C+S%3BMahadevan%2C+A%3BYasha%2C+T+C%3BGayathri%2C+N&rft.aulast=Bindu&rft.aufirst=P&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Neurology&rft.issn=08830738&rft_id=info:doi/10.1177%2F0883073807307104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Triacylglycerol lipase; storage diseases; Hereditary diseases; Calcification; Leukocytes; Hyperlipidemia; Siblings; Cholesterol; Ophthalmoplegia; Esters DO - http://dx.doi.org/10.1177/0883073807307104 ER - TY - JOUR T1 - Sensitivity of the erythrocyte micronucleus assay: Dependence on number of cells scored and inter-animal variability AN - 21055976; 7786314 AB - Until recently, the in vivo erythrocyte micronucleus assay has been scored using microscopy. Because the frequency of micronucleated cells is typically low, cell counts are subject to substantial binomial counting error. Counting error, along with inter-animal variability, limit the sensitivity of this assay. Recently, flow cytometric methods have been developed for scoring micronucleated erythrocytes and these methods enable many more cells to be evaluated than is possible with microscopic scoring. Using typical spontaneous micronucleus frequencies reported in mice, rats, and dogs we calculate the counting error associated with the frequency of micronucleated reticulocytes as a function of the number of reticulocytes scored. We compare this counting error with the inter-animal variability determined by flow cytometric scoring of sufficient numbers of cells to assure that the counting error is less than the inter-animal variability, and calculate the minimum increases in micronucleus frequency that can be detected as a function of the number of cells scored. The data show that current regulatory guidelines allow low power of the test when spontaneous frequencies are low (e.g., approximately equal to 0.1%). Tables and formulas are presented that provide the necessary numbers of cells that must be scored to meet the recommendation of the International Working Group on Genotoxicity Testing that sufficient cells be scored to reduce counting error to less than the inter-animal variability, thereby maintaining a more uniform power of detection of increased micronucleus frequencies across laboratories and species. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Kissling, GE AU - Dertinger, S D AU - Hayashi, M AU - MacGregor, J T AD - Research Triangle Park, NC 27709, United States, kissling@niehs.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 235 EP - 240 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 634 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Toxicology Abstracts KW - Flow cytometry KW - Data processing KW - Erythrocytes KW - Microscopy KW - Genotoxicity testing KW - Enumeration KW - Reticulocytes KW - Mutagenesis KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21055976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Sensitivity+of+the+erythrocyte+micronucleus+assay%3A+Dependence+on+number+of+cells+scored+and+inter-animal+variability&rft.au=Kissling%2C+GE%3BDertinger%2C+S+D%3BHayashi%2C+M%3BMacGregor%2C+J+T&rft.aulast=Kissling&rft.aufirst=GE&rft.date=2007-12-01&rft.volume=634&rft.issue=1-2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2007.07.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Data processing; Microscopy; Erythrocytes; Genotoxicity testing; Enumeration; Reticulocytes; Mutagenesis DO - http://dx.doi.org/10.1016/j.mrgentox.2007.07.010 ER - TY - JOUR T1 - Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry AN - 21004659; 7932007 AB - Chlamydia trachomatis is an obligate intracellular pathogen of humans that exhibits species-specific biological characteristics in its early interactions with host cells that are likely important to pathogenesis. One such characteristic is the tyrosine phosphorylation (Tyr-P) of an similar to 70-kDa polypeptide that occurs only after infection of mammalian cells by human strains. We sought to identify this protein because of its potential significance to the pathogenesis of human chlamydial infections. Using an immunoproteomic approach we identified the host protein ezrin, a member of the ezrin-radixin-moesin (ERM) protein family that serves as a physical link between host cell receptors and the actin cytoskeleton. Confocal microscopy studies showed colocalization of ezrin and actin at the tips and crypts of microvilli, the site of chlamydial attachment and entry, respectively. To demonstrate a functional role for ezrin we infected cells with a dominant-negative (DN) ezrin phenotype or treated cells with ezrin-specific small interfering RNA (siRNA). We found that both DN and siRNA-treated cells were significantly less susceptible to infection by human chlamydial strains. Moreover, we demonstrated that inhibition of infection in ezrin DN cells occurred at the stage of chlamydial entry. We hypothesize that the C. trachomatis-specific Tyr-P of ezrin might relate to an undefined species-specific mechanism of pathogen entry that involves chlamydial specific ligand(s) and host cell coreceptor usage. JF - Infection and Immunity AU - Swanson, Kena A AU - Crane, Deborah D AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 58940 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 5669 EP - 5677 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - ezrin KW - Chlamydia trachomatis KW - Tyrosine KW - Pathogens KW - Infection KW - Cytoskeleton KW - ERM protein KW - Phosphorylation KW - siRNA KW - Mammalian cells KW - Confocal microscopy KW - Actin KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Chlamydia+trachomatis+Species-Specific+Induction+of+Ezrin+Tyrosine+Phosphorylation+Functions+in+Pathogen+Entry&rft.au=Swanson%2C+Kena+A%3BCrane%2C+Deborah+D%3BCaldwell%2C+Harlan+D&rft.aulast=Swanson&rft.aufirst=Kena&rft.date=2007-12-01&rft.volume=75&rft.issue=12&rft.spage=5669&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; ERM protein; ezrin; Mammalian cells; siRNA; Phosphorylation; Confocal microscopy; Tyrosine; Actin; Pathogens; Infection; Chlamydia trachomatis ER - TY - JOUR T1 - Genomics and the mechanism of P-glycoprotein (ABCB1) AN - 20987903; 8151181 AB - The development of effective clinical interventions against multidrug resistance (MDR) in cancer remains a significant challenge. Single nucleotide polymorphisms (SNPs) contribute to wide variations in how individuals respond to medications and there are several SNPs in human P-glycoprotein (P-gp) that may influence the interactions of drug-substrates with the transporter. Interestingly, even some of the synonymous SNPs have functional consequences for P-gp. It is also becoming increasingly evident that an understanding of the transport pathway of P-gp may be necessary to design effective modulators. In this review we discuss: (1) The potential importance of SNPs (both synonymous and non-synonymous) in MDR and (2) How new concepts that have emerged from structural studies with isolated nucleotide binding domains of bacterial ABC transporters have prompted biochemical studies on P-gp, leading to a better understanding of the mechanism of P-gp mediated transport. Our results suggest that the power-stroke is provided only after formation of the pre-hydrolysis transition-like (E.S) state during ATP hydrolysis. JF - Journal of Bioenergetics and Biomembranes AU - Sauna, Zuben E AU - Kim, In-Wha AU - Ambudkar, Suresh V AD - National Institutes of Health, DHHS, Building 37, Room 2120, 37 Convent Drive, Bethesda, MD, 20892-4256, USA, ambudkar@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 481 EP - 487 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 39 IS - 5-6 SN - 0145-479X, 0145-479X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - P-Glycoprotein KW - Single-nucleotide polymorphism KW - ABC transporter KW - Reviews KW - ATP KW - Multidrug resistance KW - genomics KW - Hydrolysis KW - Cancer KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bioenergetics+and+Biomembranes&rft.atitle=Genomics+and+the+mechanism+of+P-glycoprotein+%28ABCB1%29&rft.au=Sauna%2C+Zuben+E%3BKim%2C+In-Wha%3BAmbudkar%2C+Suresh+V&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2007-12-01&rft.volume=39&rft.issue=5-6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bioenergetics+and+Biomembranes&rft.issn=0145479X&rft_id=info:doi/10.1007%2Fs10863-007-9115-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - P-Glycoprotein; ABC transporter; Single-nucleotide polymorphism; Reviews; ATP; Multidrug resistance; genomics; Hydrolysis; Cancer DO - http://dx.doi.org/10.1007/s10863-007-9115-9 ER - TY - JOUR T1 - Robust Strategies for Automated AFM Force Curve Analysis-II: Adhesion-Influenced Indentation of Soft, Elastic Materials AN - 20823279; 8364259 AB - In the first of this two-part discourse on the extraction of elastic properties from atomic force microscopy (AFM) data, a scheme for automating the analysis of force-distance curves was introduced and experimentally validated for the Hertzian (i.e., linearly elastic and noninteractive probe-sample pairs) indentation of soft, inhomogeneous materials. In the presence of probe-sample adhesive interactions, which are common especially during retraction of the rigid tip from soft materials, the Hertzian models are no longer adequate. A number of theories (e.g., Johnson-Kendall-Roberts and Derjaguin-Muller-Toporov), covering the full range of sample compliance relative to adhesive force and tip radius, are available for analysis of such data. We incorporated Pietrement and Troyon's approximation (2000, 'General Equations Describing Elastic Indentation Depth and Normal Contact Stiffness Versus Load,' J. Colloid Interface Sci., 226(1), pp. 166-171) of the Maugis-Dugdale model into the automated procedure. The scheme developed for the processing of Hertzian data was extended to allow for adhesive contact by applying the Pietrement-Troyon equation. Retraction force-displacement data from the indentation of polyvinyl alcohol gels were processed using the customized software. Many of the retraction curves exhibited strong adhesive interactions that were absent in extension. We compared the values of Young's modulus extracted from the retraction data to the values obtained from the extension data and from macroscopic uniaxial compression tests. Application of adhesive contact models and the automated scheme to the retraction curves yielded average values of Young's modulus close to those obtained with Hertzian models for the extension curves. The Pietrement-Troyon equation provided a good fit to the data as indicated by small values of the mean-square error. The Maugis-Dugdale theory is capable of accurately modeling adhesive contact between a rigid spherical indenter and a soft, elastic sample. Pietrement and Troyon's empirical equation greatly simplifies the theory and renders it compatible with the general automation strategies that we developed for Hertzian analysis. Our comprehensive algorithm for automated extraction of Young's moduli from AFM indentation data has been expanded to recognize the presence of either adhesive or Hertzian behavior and apply the appropriate contact model. JF - Journal of Biomechanical Engineering, Transactions of the ASME AU - Lin, David C AU - Dimitriadis, Emilios K AU - Horkay, Ferenc AD - Laboratory of Integrative and Medical Biophysics, National Institutes of Health, 9 Memorial Drive, Building 9, Room 1E118, Bethesda, MD 20892 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 904 EP - 912 PB - American Society of Mechanical Engineers, United Engineering Center, 345 E. 47th St. New York NY 10017 USA, [URL:http://www.asme.org] VL - 129 IS - 6 SN - 0148-0731, 0148-0731 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Data processing KW - Colloids KW - Algorithms KW - atomic force microscopy KW - Automation KW - Compression KW - Gels KW - Polyvinyl alcohol KW - Computer programs KW - software KW - Adhesives KW - Mechanical properties KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.atitle=Robust+Strategies+for+Automated+AFM+Force+Curve+Analysis-II%3A+Adhesion-Influenced+Indentation+of+Soft%2C+Elastic+Materials&rft.au=Lin%2C+David+C%3BDimitriadis%2C+Emilios+K%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2007-12-01&rft.volume=129&rft.issue=6&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.issn=01480731&rft_id=info:doi/10.1115%2F1.2800826 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Adhesives; Mathematical models; atomic force microscopy; Mechanical properties; Computer programs; Compression; Algorithms; software; Polyvinyl alcohol; Gels; Colloids; Automation DO - http://dx.doi.org/10.1115/1.2800826 ER - TY - JOUR T1 - Hock immunization: A humane alternative to mouse footpad injections AN - 20773171; 8243139 AB - Footpad injection is a commonly used immunization method in mice. Being relatively easy to do with well-characterized lymphatic drainage, it has become a very useful immunization protocol to study local immune responses in draining lymph nodes. However, its disadvantages include use of only hind feet as a routine site of immunization since mice use their fore feet for food handling, and exacerbation of inflammation and swelling at the injection site leading to unrelieved pain and distress since feet are weight-bearing structures. With increasingly stringent Institutional guidelines for animal manipulations, there is increasing need for more humane protocols. A novel immunization protocol involving injection into the hock, the lateral tarsal region just above the ankle, a non-weight bearing structure draining to the same lymph node as the footpad, retains the advantages of footpad immunization without its drawbacks. This study, comparing immune responses between footpad and hock immunization in six different inbred mouse strains to two different protein antigens and a heat-killed bacterium, shows that hock immunization is a better alternative to footpad immunization, inducing comparable immune responses and being considerably more humane. JF - Journal of Immunological Methods AU - Kamala, T AD - Room 111, LCMI, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892, United States, tkamala@niaid.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 204 EP - 214 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 328 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Food KW - Drainage KW - Ankle KW - Pain KW - Immunization KW - Lymph nodes KW - Inflammation KW - F 06900:Methods KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Hock+immunization%3A+A+humane+alternative+to+mouse+footpad+injections&rft.au=Kamala%2C+T&rft.aulast=Kamala&rft.aufirst=T&rft.date=2007-12-01&rft.volume=328&rft.issue=1-2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drainage; Food; Pain; Ankle; Lymph nodes; Immunization; Inflammation DO - http://dx.doi.org/10.1016/j.jim.2007.08.004 ER - TY - JOUR T1 - Diet and risk of multiple myeloma in Connecticut women AN - 20736987; 7970544 AB - Multiple myeloma accounts for an estimated 19,900 incident cancer cases per year in the United States. A population-based case-control study, consisting of 179 incident cases and 691 controls, was conducted to examine the impact of diet on multiple myeloma risk. Diet was assessed using a food frequency questionnaire and odds ratios, 95% confidence intervals, and P-trends were calculated across quartiles of consumption. After controlling for potential confounders, we observed inverse associations for cooked tomatoes (P-trend = 0.002), cruciferous vegetables (P-trend = 0.01), fresh fish (P-trend < 0.001), alcohol (P-trend < 0.001), and vitamin A (P-trend < 0.001) with multiple myeloma risk. In contrast, consumption of cream soups (P-trend = 0.01), jello (P-trend = 0.01), ice cream (P-trend = 0.01), and pudding (P-trend < 0.001) were positively associated with multiple myeloma. Furthermore, there was a suggestion that carbohydrate intake may be positively associated, whereas vitamin D and calcium intake may be inversely associated, with multiple myeloma risk. Despite very limited data on dietary factors in relation to multiple myeloma, the findings from this study concur with previously published studies, suggesting an inverse association for consumption of fish, cruciferous vegetables and green vegetables, and a positive association for some dairy products. JF - Cancer Causes & Control AU - Hosgood, HDean AU - Baris, Dalsu AU - Zahm, Shelia Hoar AU - Zheng, Tongzhang AU - Cross, Amanda J AD - National Institutes of Health, 6120 Executive Blvd., EPS 8118, MCS 7240, Bethesda, MD, 20892-7240, USA, hosgoodd@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1065 EP - 1076 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Immunology Abstracts KW - Vegetables KW - Calcium KW - USA, Connecticut KW - Food KW - Dairy products KW - Lycopersicon esculentum KW - vitamins KW - Multiple myeloma KW - Soups KW - alcohols KW - Cream KW - Carbohydrates KW - Diets KW - Alcohol KW - Inventories KW - multiple myeloma KW - Cancer KW - Vitamin D KW - Ice cream KW - Vitamin A KW - Fish KW - Females KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20736987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Diet+and+risk+of+multiple+myeloma+in+Connecticut+women&rft.au=Hosgood%2C+HDean%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+Hoar%3BZheng%2C+Tongzhang%3BCross%2C+Amanda+J&rft.aulast=Hosgood&rft.aufirst=HDean&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9047-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Inventories; Vegetables; Calcium; Food; Dairy products; Cancer; Vitamin D; Multiple myeloma; Ice cream; Soups; Vitamin A; Cream; alcohols; Carbohydrates; Alcohol; vitamins; multiple myeloma; Fish; Females; Lycopersicon esculentum; USA, Connecticut DO - http://dx.doi.org/10.1007/s10552-007-9047-z ER - TY - JOUR T1 - Dairy Products, Calcium Intake, and Risk of Prostate Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20726371; 7933576 AB - Higher intakes of calcium and dairy products, a major source of dietary calcium, are reported to increase the risk of prostate cancer, potentially due to reductions in circulating vitamin D with increasing calcium intake. We prospectively examined the association of dairy product and calcium intake with prostate cancer risk in 29,509 men, including 1,910 cases, in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We also evaluated the relation of calcium intake with serum 25-hydroxy-vitamin D [25(OH)D] and 1,25-dihydroxy-vitamin D [1,25(OH) sub(2)D], in a Prostate, Lung, Colorectal, and Ovarian Trial substudy (n = 275). Dietary intake was assessed using a food frequency questionnaire. Baseline serum 1,25(OH) sub(2)D was determined by RIA. Greater intake of dairy products, particularly low-fat dairy products, was weakly associated with increased risk of prostate cancer [relative risk (RR), 1.12; 95% confidence intervals (CI), 0.97-1.30; P trend = 0.06 for >2.75 versus less than or equal to 0.98 servings of total dairy/day; 1.23 (1.07-1.41) for low-fat dairy]. Greater dietary calcium intake was associated with increased risk of prostate cancer (RR, 1.34; 95% CI, 0.93-1.94; P trend = 0.02 for >2,000 versus <1,000 mg/day), but greater supplementary calcium intake was not associated with the risk. Associations of dairy product and dietary calcium intake were evident for nonaggressive disease (RR, 1.20; 95% CI, 0.99-1.46; P trend = 0.01 for dairy products; 1.64, 1.04-2.57; P trend = 0.002 for dietary calcium), but not aggressive disease (RR, 1.02; 95% CI, 0.81-1.28 for dairy products; 0.94, 0.49-1.80 for dietary calcium). Calcium intake was not associated with serum 25-hydroxy-vitamin D and 1,25(OH) sub(2)D concentration. In this large prospective study in a prostate cancer screening trial, greater dietary intake of calcium and dairy products, particularly low-fat types, may be modestly associated with increased risks for nonaggressive prostate cancer, but was unrelated to aggressive disease. Furthermore, we found no relationship between calcium intake and circulating vitamin D. (Cancer Epidemiol Biomarkers Prev 2007; 16(12):2623-30) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Peters, Ulrike AU - Schatzkin, Arthur AU - Lim, Unhee AU - Freedman, Michal AU - Chatterjee, Nilanjan AU - Andriole, Gerald L AU - Leitzmann, Michael F AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2623 EP - 2630 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Bioindicators KW - Risk assessment KW - Ovarian cancer KW - Inventories KW - Calcium KW - ovarian carcinoma KW - Food KW - Dairy products KW - Ingestion KW - Dietary intake KW - biomarkers KW - Cancer KW - Dairies KW - vitamins KW - Prostate cancer KW - Calcium (dietary) KW - Vitamin D KW - Lung KW - prevention KW - prostate cancer KW - R2 23110:Psychological aspects KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Dairy+Products%2C+Calcium+Intake%2C+and+Risk+of+Prostate+Cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Ahn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BPeters%2C+Ulrike%3BSchatzkin%2C+Arthur%3BLim%2C+Unhee%3BFreedman%2C+Michal%3BChatterjee%2C+Nilanjan%3BAndriole%2C+Gerald+L%3BLeitzmann%2C+Michael+F%3BHayes%2C+Richard+B&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2623&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inventories; Ovarian cancer; Vitamin D; Calcium (dietary); Prostate cancer; Lung; Food; Dairy products; biomarkers; Dietary intake; Bioindicators; Diets; Dairies; vitamins; Calcium; ovarian carcinoma; prevention; Ingestion; prostate cancer; Cancer ER - TY - JOUR T1 - Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma AN - 20724372; 7933525 AB - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. JF - Carcinogenesis AU - Brenner, A V AU - Butler, MA AU - Wang, S S AU - Ruder, A M AU - Rothman, N AU - Schulte, P A AU - Chanock, S J AU - Fine, HA AU - Linet AU - Inskip, P D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA. Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2543 EP - 2547 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 12 SN - 0143-3334, 0143-3334 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Historical account KW - Interleukin 4 KW - Etiology KW - Occupational safety KW - Autoimmune diseases KW - autoimmune diseases KW - Population studies KW - Allergies KW - Cancer KW - Brain tumors KW - glioma KW - Hypersensitivity KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - Cytokines KW - Glioma KW - G 07720:Immunogenetics KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health KW - N 14845:Miscellaneous KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Single-nucleotide+polymorphisms+in+selected+cytokine+genes+and+risk+of+adult+glioma&rft.au=Brenner%2C+A+V%3BButler%2C+MA%3BWang%2C+S+S%3BRuder%2C+A+M%3BRothman%2C+N%3BSchulte%2C+P+A%3BChanock%2C+S+J%3BFine%2C+HA%3BLinet%3BInskip%2C+P+D&rft.aulast=Brenner&rft.aufirst=A&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Brain tumors; Etiology; Hypersensitivity; Interleukin 4; Single-nucleotide polymorphism; Autoimmune diseases; Carcinogenesis; Population studies; Cytokines; Glioma; Historical account; glioma; Occupational safety; autoimmune diseases; Allergies; Cancer ER - TY - JOUR T1 - Calcium, Dairy Foods, and Risk of Incident and Fatal Prostate Cancer: The NIH-AARP Diet and Health Study AN - 20723956; 7928759 AB - Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and 95% confidence intervals were estimated by Cox regression. During up to 6 years of follow-up (n = 293,888), the authors identified 10,180 total prostate cancer cases (8,754 nonadvanced, 1,426 advanced, and 178 fatal cases). Total and supplemental calcium were unrelated to total and nonadvanced prostate cancer. However, a statistically nonsignificant positive association with total calcium was observed for advanced ( greater than or equal to 2,000 vs. 500-<750 mg/day: relative risk (RR) = 1.25, 95% confidence interval (CI): 0.91, 1.71; p sub(trend) = 0.06) and fatal ( greater than or equal to 1,000 vs. 500-<750 mg/day: RR = 1.39, 95% CI: 0.92, 2.09; p sub(trend) = 0.10) prostate cancer. Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer ( greater than or equal to 2 vs. zero servings/day: RR = 1.23, 95% CI: 0.99, 1.54; p sub(trend) = 0.01). In contrast, calcium from nondairy foods was associated with lower risk of nonadvanced prostate cancer ( greater than or equal to 600 vs. <250 mg/day: RR = 0.82, 95% CI: 0.68, 0.99; p sub(trend) = 0.04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk. JF - American Journal of Epidemiology AU - Park, Yikyung AU - Mitrou, Panagiota N AU - Kipnis, Victor AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 1270 EP - 1279 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 11 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Risk assessment KW - Inventories KW - Milk KW - Calcium KW - Food KW - Dairy products KW - Skim milk KW - Dairies KW - Prostate cancer KW - Risk factors KW - prostate cancer KW - R2 23110:Psychological aspects KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Calcium%2C+Dairy+Foods%2C+and+Risk+of+Incident+and+Fatal+Prostate+Cancer%3A+The+NIH-AARP+Diet+and+Health+Study&rft.au=Park%2C+Yikyung%3BMitrou%2C+Panagiota+N%3BKipnis%2C+Victor%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Park&rft.aufirst=Yikyung&rft.date=2007-12-01&rft.volume=166&rft.issue=11&rft.spage=1270&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Diets; Inventories; Dairies; Calcium; Prostate cancer; Risk factors; Food; Dairy products; Skim milk; Milk; prostate cancer ER - TY - JOUR T1 - Toxicity of Panax Genseng - An Herbal Medicine and Dietary Supplement AN - 20683945; 8111330 AB - Ginseng is one of the most popular herbal dietary supplements in the U.S. market, with five to six million persons using it even before the recent boom in the herbal supplement industry. Ginsana (G115 ginseng), a standardized extract of Panax ginseng (Asian ginseng, also called Chinese or Korean ginseng) controls half of this market. Numerous reports of adverse effects from products containing ginseng have been filed with the U.S. Food and Drug Administration (FDA). The literature also documents "ginseng abuse syndrome" among regular users. The chronic effects of ginseng are not well characterized. Because of its significant human exposure and little information on toxicity is available, Panax ginseng has been nominated by the U.S. National Institutes of Health (NIH) to the U.S. National Toxicology Program (NTP) for assessing its carcinogenic potential. In this review, we discuss the environmental occurrence, purported therapeutic effects, biological effects, and toxicity of ginseng, with focus on Panax ginseng. To demonstrate how NTP chronic tumorigenicity bioassays are conducted, the tumorigenicity bioassay of Panax ginseng is detailed described. JF - Journal of Food and Drug Analysis AU - Chan, P-C AU - Fu, P P AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, chanp@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 416 EP - 427 VL - 15 IS - 4 SN - 1021-9498, 1021-9498 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Panax ginseng KW - dietary supplements KW - herbal medicines KW - biological effects KW - Tumorigenicity KW - Panax KW - Ginseng KW - Toxicity KW - Abuse KW - USA KW - Bioassays KW - Carcinogenicity KW - Reviews KW - Dietary supplements KW - Chronic effects KW - FDA KW - Herbal medicines KW - Drugs KW - Toxicology KW - Side effects KW - H 14000:Toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20683945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+and+Drug+Analysis&rft.atitle=Toxicity+of+Panax+Genseng+-+An+Herbal+Medicine+and+Dietary+Supplement&rft.au=Chan%2C+P-C%3BFu%2C+P+P&rft.aulast=Chan&rft.aufirst=P-C&rft.date=2007-12-01&rft.volume=15&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+and+Drug+Analysis&rft.issn=10219498&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chronic effects; Dietary supplements; Herbal medicines; Tumorigenicity; Ginseng; Toxicity; Abuse; Side effects; Bioassays; herbal medicines; dietary supplements; biological effects; Carcinogenicity; Reviews; FDA; Drugs; Toxicology; Panax ginseng; Panax; USA ER - TY - JOUR T1 - Advocacy for Malaria Prevention, Control, and Research in the Twenty-First Century AN - 20676236; 8015395 AB - Until recent years, public interest and political investment in malaria prevention, control, and research have been stagnant. The global malaria agenda is now experiencing an unprecedented time of public and political will and momentum. At the heart of this favorable period lies a nascent, but increasingly sophisticated, global advocacy effort that has contributed to new and expanded malaria funding, programs, and technology. This paper reviews the elements of malaria's rise to political and public prominence, tracks the increase in funding and policy commitments to malaria over the past decade, and comments on an evolving policymaking progress, increasing transparency and accountability in program governance, and the impact of philanthropic investments in malaria advocacy. In addition, the principles of sound advocacy are described along with the mechanisms that will underlie sustained pro-political momentum for malaria research, resources, and results. "Today, we have begun to write the final chapter in the history of malaria. We have raised hopes and expectations of our people--we must not let them down. We cannot afford to let them down." --His Excellency Olusegan Obasanjo, President of Nigeria, Abuja Summit 2000. JF - American Journal of Tropical Medicine and Hygiene AU - Bates, N AU - Herrington, J AD - Fogarty International Center, Bldg. 31, Rm. B2C11, National Institutes of Health, Bethesda, MD 20892-2220, USA, herringtonj@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 314 EP - 320 VL - 77 SN - 0002-9637, 0002-9637 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Nigeria KW - Human diseases KW - Policies KW - Sociological aspects KW - Financing KW - Sound KW - Disease control KW - Malaria KW - Public health KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20676236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Advocacy+for+Malaria+Prevention%2C+Control%2C+and+Research+in+the+Twenty-First+Century&rft.au=Bates%2C+N%3BHerrington%2C+J&rft.aulast=Bates&rft.aufirst=N&rft.date=2007-12-01&rft.volume=77&rft.issue=&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - SuppNotes - Special Issue: Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives. N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Policies; Human diseases; Sociological aspects; Financing; Disease control; Malaria; Public health; Sound; Nigeria ER - TY - JOUR T1 - Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts AN - 20651489; 8079799 AB - The CHEK2-1100delC mutation is recurrent in the population and is a moderate risk factor for breast cancer. To identify additional CHEK2 mutations potentially contributing to breast cancer susceptibility, we sequenced 248 cases with early-onset disease; functionally characterized new variants and conducted a population-based case-control analysis to evaluate their contribution to breast cancer risk. We identified 1 additional null mutation and 5 missense variants in the germline of cancer patients. In vitro, the CHEK2-H143Y variant resulted in gross protein destabilization, while others had variable suppression of in vitro kinase activity using BRCA1 as a substrate. The germline CHEK2-1100delC mutation was present among 8/1,646 (0.5%) sporadic, 2/400 (0.5%) early-onset and 3/302 (1%) familial breast cancer cases, but undetectable amongst 2,105 multiethnic controls, including 633 from the US. CHEK2-positive breast cancer families also carried a deleterious BRCA1 mutation. 1100delC appears to be the only recurrent CHEK2 mutation associated with a potentially significant contribution to breast cancer risk in the general population. Another recurrent mutation with attenuated in vitro function, CHEK2-P85L, is not associated with increased breast cancer susceptibility, but exhibits a striking difference in frequency across populations with different ancestral histories. These observations illustrate the importance of genotyping ethnically diverse groups when assessing the impact of low-penetrance susceptibility alleles on population risk. Our findings highlight the notion that clinical testing for rare missense mutations within CHEK2 may have limited value in predicting breast cancer risk, but that testing for the 1100delC variant may be valuable in phenotypically- and geographically-selected populations. JF - International Journal of Cancer AU - Bell, Daphne W AU - Kim, Sang H AU - Godwin, Andrew K AU - Schiripo, Taryn A AU - Harris, Patricia L AU - Haserlat, Sara M AU - Wahrer, Doke C R AU - Haiman, Christopher A AU - Daly, Mary B AU - Niendorf, Kristin B AU - Smith, Matthew R AU - Sgroi, Dennis C AU - Garber, Judy E AU - Olopade, Olufunmilayo I AU - Le Marchand, Loic AU - Henderson, Brian E AU - Altshuler, David AU - Haber, Daniel A AU - Freedman, Matthew L AD - Massachusetts General Hospital Cancer Center, Charlestown, MA, belldaph@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2661 EP - 2667 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 12 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Historical account KW - Age KW - Missense mutation KW - Genotyping KW - functional analysis KW - Population genetics KW - Risk factors KW - Proteins KW - Breast cancer KW - BRCA1 protein KW - Mutation KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Genetic+and+functional+analysis+of+CHEK2+%28CHK2%29+variants+in+multiethnic+cohorts&rft.au=Bell%2C+Daphne+W%3BKim%2C+Sang+H%3BGodwin%2C+Andrew+K%3BSchiripo%2C+Taryn+A%3BHarris%2C+Patricia+L%3BHaserlat%2C+Sara+M%3BWahrer%2C+Doke+C+R%3BHaiman%2C+Christopher+A%3BDaly%2C+Mary+B%3BNiendorf%2C+Kristin+B%3BSmith%2C+Matthew+R%3BSgroi%2C+Dennis+C%3BGarber%2C+Judy+E%3BOlopade%2C+Olufunmilayo+I%3BLe+Marchand%2C+Loic%3BHenderson%2C+Brian+E%3BAltshuler%2C+David%3BHaber%2C+Daniel+A%3BFreedman%2C+Matthew+L&rft.aulast=Bell&rft.aufirst=Daphne&rft.date=2007-12-01&rft.volume=121&rft.issue=12&rft.spage=2661&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Population genetics; Missense mutation; Age; Risk factors; Genotyping; BRCA1 protein; Breast cancer; Historical account; Proteins; functional analysis; Mutation DO - http://dx.doi.org/10.1002/ijc.23026 ER - TY - JOUR T1 - Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer AN - 20650287; 8079780 AB - Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early-onset malignancies, and somatic mutations occur in 20-40% of all breast cancer cases. We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer. Single nucleotide polymorphisms (SNPs) identified in a re-sequence analysis were genotyped in 2 large case-control studies including 731 cases and 1,124 controls from Norway, and 1,995 cases and 2,296 controls from Poland. Analyses of the pooled data showed no SNPs in TP53 to be significantly associated with risk for breast cancer. However, we found a significant and consistent association with risk for a SNP in exon 1 (R68G) of the 5 neighboring gene WDR79 (rs2287499, OR (95% CI) = 1.08 (0.95-1.23) for CG vs. CC and 1.60 (1.04-2.47) for GG vs. CC, p-trend = 0.01). Stratification by ER and PR status, showed these increases in risk to be limited to ER negative tumors (OR (95% CI) per variant allele: 1.42 (1.18-1.71) p-trend = 0.00009). In addition, 2 TP53 SNPs (rs17887200 3of STP and rs12951053 in intron 7) showing weak and non-significant overall increases in risk, were also associated with ER negative tumors (1.48 (1.11-1.93) p-trend = 0.01 and 1.29 (1.06-1.58) p-trend = 0.009, respectively). In conclusion, this comprehensive evaluation of common genetic variation in TP53 and its flanking genes found no significant overall associations between SNPs in TP53 and breast cancer risk. However, data suggested that common variation in TP53 or WDR79 could be associated with ER negative breast cancers. JF - International Journal of Cancer AU - Garcia-Closas, Montserrat AU - Kristensen, Vessela AU - Langerod, Anita AU - Qi, Ying AU - Yeager, Meredith AU - Burdett, Laurie AU - Welch, Robert AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Brinton, Louise AU - Gerhard, Daniela S AU - Gram, Inger Torhild AU - Perou, Charles M AU - Borresen-Dale, Anne-Lise AU - Chanock, Stephen AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, garciacm@exchange.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2532 EP - 2538 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 11 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Age KW - Exons KW - Genetic diversity KW - genetic diversity KW - Stratification KW - Tumors KW - p53 protein KW - Malignancy KW - introns KW - Single-nucleotide polymorphism KW - Poland KW - Introns KW - Breast cancer KW - Norway KW - Mutation KW - G 07880:Human Genetics KW - B 26670:Tumor Suppressors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20650287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Common+genetic+variation+in+TP53+and+its+flanking+genes%2C+WDR79+and+ATP1B2%2C+and+susceptibility+to+breast+cancer&rft.au=Garcia-Closas%2C+Montserrat%3BKristensen%2C+Vessela%3BLangerod%2C+Anita%3BQi%2C+Ying%3BYeager%2C+Meredith%3BBurdett%2C+Laurie%3BWelch%2C+Robert%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BBrinton%2C+Louise%3BGerhard%2C+Daniela+S%3BGram%2C+Inger+Torhild%3BPerou%2C+Charles+M%3BBorresen-Dale%2C+Anne-Lise%3BChanock%2C+Stephen&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2007-12-01&rft.volume=121&rft.issue=11&rft.spage=2532&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22985 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Age; Malignancy; Exons; Single-nucleotide polymorphism; Introns; Genetic diversity; Breast cancer; Tumors; Mutation; p53 protein; introns; genetic diversity; Stratification; Poland; Norway DO - http://dx.doi.org/10.1002/ijc.22985 ER - TY - JOUR T1 - Fruit and vegetable intake and esophageal cancer in a large prospective cohort study AN - 20624182; 8079813 AB - Changing patterns of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) incidence worldwide suggest distinct etiologies. Although associations between fruit and vegetable intake and both ESCC and EAC have been found in multiple ecological and case-control studies, few prospective studies have investigated these associations. We prospectively examined these associations in 490,802 participants of the National Institutes of Health (NIH)-AARP Diet and Health Study using Cox models adjusted for age, alcohol intake, body mass index, cigarette smoking, education, physical activity and total energy intake. We present hazard ratios and 95% confidence intervals per serving per 1,000 calories. During 2,193,751 person years of follow-up, 103 participants were diagnosed with ESCC and 213 participants with EAC. We found a significant inverse association between total fruit and vegetable intake and ESCC risk (HR: 0.78, 95% CI: 0.67-0.91), but not EAC risk (0.9,0.90-1.08). In models mutually adjusted for fruit and vegetable intake, the protective association with ESCC was stronger for fruits (0.7,0.57-0.93) than for vegetables (0.8,0.66-1.07). When we examined botanical subgroups, we observed significant protective associations for ESCC and intake of Rosacea (apples, peaches, nectarines, plums, pears and strawberries) and Rutaceae (citrus fruits). A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type. JF - International Journal of Cancer AU - Freedman, Neal D AU - Park, Yikyung AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, freedmanne@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2753 EP - 2760 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 12 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Rutaceae KW - Citrus KW - Age KW - Fragaria KW - Prunus KW - Rosacea KW - Chenopodiaceae KW - body mass KW - Cigarette smoking KW - Spinacia oleracea KW - physical activity KW - Diets KW - Alcohol KW - Etiology KW - fruits KW - Cancer KW - Education KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20624182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Fruit+and+vegetable+intake+and+esophageal+cancer+in+a+large+prospective+cohort+study&rft.au=Freedman%2C+Neal+D%3BPark%2C+Yikyung%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-12-01&rft.volume=121&rft.issue=12&rft.spage=2753&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22993 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Citrus; Prunus; Chenopodiaceae; Spinacia oleracea; Rutaceae; Fragaria; Rosacea; fruits; Cancer; Alcohol; Diets; Education; Cigarette smoking; body mass; physical activity; Age; Etiology DO - http://dx.doi.org/10.1002/ijc.22993 ER - TY - JOUR T1 - A semiparametric pseudo-score method for analysis of two-phase studies with continuous phase-I covariates AN - 20596664; 8148224 AB - Two-phase study designs can reduce cost and other practical burdens associated with large scale epidemiologic studies by limiting ascertainment of expensive covariates to a smaller but informative sub-sample (phase-II) of the main study (phase-I). During the analysis of such studies, however, subjects who are selected at phase-I but not at phase-II, remain informative as they may have partial covariate information. A variety of semi-parametric methods now exist for incorporating such data from phase-I subjects when the covariate information can be summarized into a finite number of strata. In this article, we consider extending the pseudo-score approach proposed by Chatterjee et al. (J Am Stat Assoc 98:158-168, 2003) using a kernel smoothing approach to incorporate information on continuous phase-I covariates. Practical issues and algorithms for implementing the methods using existing software are discussed. A sandwich-type variance estimator based on the influence function representation of the pseudo-score function is proposed. Finite sample performance of the methods are studies using simulated data. Advantage of the proposed smoothing approach over alternative methods that use discretized phase-I covariate information is illustrated using two-phase data simulated within the National Wilms Tumor Study (NWTS). JF - Lifetime Data Analysis AU - Chatterjee, Nilanjan AU - Chen, Yi-Hau AD - National Cancer Institute, NIH, DHHS, Rockville, MD, 20852, USA, chattern@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 607 EP - 622 PB - Kluwer Academic Publishers, [mailto:sales@wkap.nl], [URL:http://www.kluweronline.com/] VL - 13 IS - 4 SN - 1380-7870, 1380-7870 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20596664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lifetime+Data+Analysis&rft.atitle=A+semiparametric+pseudo-score+method+for+analysis+of+two-phase+studies+with+continuous+phase-I+covariates&rft.au=Chatterjee%2C+Nilanjan%3BChen%2C+Yi-Hau&rft.aulast=Chatterjee&rft.aufirst=Nilanjan&rft.date=2007-12-01&rft.volume=13&rft.issue=4&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Lifetime+Data+Analysis&rft.issn=13807870&rft_id=info:doi/10.1007%2Fs10985-007-9066-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s10985-007-9066-9 ER - TY - JOUR T1 - Overview of monoclonal B-cell lymphocytosis AN - 20588748; 7978368 AB - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL. JF - British Journal of Haematology AU - Marti, Gerald AU - Abbasi, Fatima AU - Raveche, Elizabeth AU - Rawstron, Andy C AU - Ghia, Paolo AU - Aurran, Therese AU - Caporaso, Neil AU - Shim, Youn K AU - Vogt, Robert F AD - Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, gemarti@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 701 EP - 708 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 139 IS - 5 SN - 0007-1048, 0007-1048 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - chronic lymphocytic leukaemia KW - monoclonal B-cell lymphocytosis KW - Lymphocytes B KW - Aging KW - Environmental health KW - Population studies KW - Toxins KW - population studies KW - Leukemia KW - Lymphocytosis KW - Differential diagnosis KW - Reviews KW - senescence KW - Geriatrics KW - Senescence KW - elderly KW - Chronic lymphatic leukemia KW - F 06915:Cancer Immunology KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Overview+of+monoclonal+B-cell+lymphocytosis&rft.au=Marti%2C+Gerald%3BAbbasi%2C+Fatima%3BRaveche%2C+Elizabeth%3BRawstron%2C+Andy+C%3BGhia%2C+Paolo%3BAurran%2C+Therese%3BCaporaso%2C+Neil%3BShim%2C+Youn+K%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2007.06865.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differential diagnosis; Lymphocytosis; Lymphocytes B; Reviews; Aging; Geriatrics; Population studies; Senescence; Chronic lymphatic leukemia; Toxins; population studies; Leukemia; senescence; Environmental health; elderly DO - http://dx.doi.org/10.1111/j.1365-2141.2007.06865.x ER - TY - JOUR T1 - Efficient Systemic Expression of Bioactive 1L-15 in Mice upon Delivery of Optimized DNA Expression Plasmids AN - 20588687; 7965529 AB - Efficient expression vectors for interleukin 15 (IL-15) were developed combining RNA/codon optimization and modification of the IL-15 native long signal peptide. These changes resulted in elevated cytoplasmic levels of the optimized mRNA and more than 100-fold improved production of secreted human IL-15 protein. Similar modifications have also led to greatly increased rhesus macaque and murine IL-15 production. Comparison of different heterologous secretory signals showed that the tissue plasminogen activator signal is most efficient for the production of extracellular IL-15. Upon intramuscular injection of the fully optimized expression vectors in mice, IL-15 was readily detected in the serum. Serum levels represented <1% of intramuscular IL-15 and were sufficient in causing some systemic effects, such as increasing the frequency of natural killer (NK) cells in the liver. Upon hydrodynamic DNA delivery in mice, very high levels of IL-15 were produced, which increased the frequency of NK cells in liver as well as in spleen and lung. These optimized expression vectors have potential applications in vaccine and immunotherapy approaches against AIDS and cancer. JF - DNA and Cell Biology AU - Jalah, R AU - Rosati, M AU - Kulkami, V AU - Patel, V AU - Bergamaschi, C AU - Valentin, A AU - Zhang, G-M AU - Sidhu, M K AU - Eldridge, J H AU - Weiner, D B AU - Pavlakis, G N AU - Felber, B K AD - Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles St., Building 535, Room 209, Frederick, MD 21702-1201, USA, felber@ncifcrf.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 827 EP - 840 VL - 26 IS - 12 SN - 1044-5498, 1044-5498 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Hydrodynamics KW - Hepatocytes KW - Immunotherapy KW - Signal peptides KW - Natural killer cells KW - Spleen KW - Plasmids KW - t-Plasminogen activator KW - Cancer KW - mRNA KW - Expression vectors KW - Serum levels KW - Interleukin 15 KW - Lung KW - Codons KW - DNA KW - Macaca mulatta KW - Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+Cell+Biology&rft.atitle=Efficient+Systemic+Expression+of+Bioactive+1L-15+in+Mice+upon+Delivery+of+Optimized+DNA+Expression+Plasmids&rft.au=Jalah%2C+R%3BRosati%2C+M%3BKulkami%2C+V%3BPatel%2C+V%3BBergamaschi%2C+C%3BValentin%2C+A%3BZhang%2C+G-M%3BSidhu%2C+M+K%3BEldridge%2C+J+H%3BWeiner%2C+D+B%3BPavlakis%2C+G+N%3BFelber%2C+B+K&rft.aulast=Jalah&rft.aufirst=R&rft.date=2007-12-01&rft.volume=26&rft.issue=12&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=DNA+and+Cell+Biology&rft.issn=10445498&rft_id=info:doi/10.1089%2Fdna.2007.0645 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Hydrodynamics; Hepatocytes; Immunotherapy; Signal peptides; Natural killer cells; Spleen; Plasmids; t-Plasminogen activator; Cancer; mRNA; Serum levels; Expression vectors; Interleukin 15; Lung; DNA; Codons; Vaccines; Macaca mulatta DO - http://dx.doi.org/10.1089/dna.2007.0645 ER - TY - JOUR T1 - Optimization of multiphoton excitation microscopy by total emission detection using a parabolic light reflector AN - 20565526; 8056756 AB - We have constructed a device that maximizes the probability of collecting all of the scattered and ballistic light isotropically generated at the focal spot of multiphoton excited emissions (MPE) to optimize the signal-to-noise ratio (SNR) for micro-imaging. This was accomplished by optically coupling a parabolic reflector (that surrounds the sample and top of the objective) to a pair of collimating lenses (above the sample) that redirects emitted light to a separate detector. These additional optics, combined with the objective, allow the total emission detection (TED) condition to be approached. Numerical simulations suggest an approximately 10-fold improvement in SNR with TED. Comparisons between the objective detection and TED reveal an enhancement of 8.9 in SNR (77% of predicted) for GFP-labelled brain slices and similar results for fluorescent beads. This increase in SNR can be used to improve time resolution, reduce laser power requirements-photodynamic damage, and, in certain cases, detection depth, for MPE imaging techniques. JF - Journal of Microscopy (Oxford) AU - Combs, Christian A AU - Smirnov, Aleksandr V AU - Riley, Jason D AU - Gandjbakhche, Amir H AU - Knutson, Jay R AU - Balaban, Robert S AD - NHLBI Light Microscopy Facility, combsc@nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 330 EP - 337 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 228 IS - 3 SN - 0022-2720, 0022-2720 KW - Biotechnology and Bioengineering Abstracts KW - Brain KW - GFP KW - light collection KW - trans-fluorescence KW - two-photon microscopy KW - Neuroimaging KW - Microscopy KW - Lasers KW - Brain slice preparation KW - Light effects KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20565526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microscopy+%28Oxford%29&rft.atitle=Optimization+of+multiphoton+excitation+microscopy+by+total+emission+detection+using+a+parabolic+light+reflector&rft.au=Combs%2C+Christian+A%3BSmirnov%2C+Aleksandr+V%3BRiley%2C+Jason+D%3BGandjbakhche%2C+Amir+H%3BKnutson%2C+Jay+R%3BBalaban%2C+Robert+S&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2007-12-01&rft.volume=228&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microscopy+%28Oxford%29&rft.issn=00222720&rft_id=info:doi/10.1111%2Fj.1365-2818.2007.01851.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Microscopy; Lasers; Brain slice preparation; Light effects DO - http://dx.doi.org/10.1111/j.1365-2818.2007.01851.x ER - TY - JOUR T1 - Malaria Surveillance Counts AN - 20556949; 8015360 AB - Clinical and epidemiologic surveillance of malaria cases and deaths is required to follow the progress of the reinvigorated malaria control programs nationally and internationally. Current recording, transmittal, analysis, feedback, and use of malaria surveillance information is delayed and imprecise: substantially < 10% of the malaria cases and deaths are being reported. Improvements are occurring, but more emphasis should be placed on prompt, accurate diagnosis, patient management, and recording of clinical manifestations at hospitals. Neurologic signs, severe anemia, metabolic changes, hyperparasitemia, and concurrent sepsis are medical emergencies and require proper clinical and laboratory detection; equipment, reagents, supervision, and certification of laboratorians and clinicians are necessary. Birth weight should also be a major measure of progress in malarial control and overall prenatal care. Although malaria is the most frequent diagnosis at outpatient clinics and hospitals in Africa, co-existing conditions also mandate improved diagnosis, treatment, and registration. Monthly transmittal of information from health units and collation, analysis and feedback through electronic reporting systems using modern information technologies are necessary for resource planning and staff motivation. Denominators to compute rates of illness and death require accurate censuses of communities from which patients come to health units: specialized disease and demographic household surveys designed and performed by nationals are needed to complement hospital-based numerator data. Plasmodium falciparum and P. vivax should be distinguished in the laboratory; the former causes the greatest mortality but the latter is increasingly recognized as a major peril. Because vector control is now a major component of all malaria control programs, there is an urgent need to monitor anopheline sensitivity to insecticides and entomologic inoculation rates. Where interrupting transmission is a goal, parasite rates in groups at greatest risk should be performed. Continual monitoring of plasmodial sensitivity to drugs is necessary using WHO protocols. Human, entomological, and parasitological surveillance must be performed at the same time in the same places and the information shared widely and used for improving control strategies and tactics. These surveillance priorities require training, provision of equipment, supervision, and commitment to sustainability by national authorities and international collaborators and donors. JF - American Journal of Tropical Medicine and Hygiene AU - Breman, J G AU - Holloway, C N AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 36 EP - 47 VL - 77 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Birth weight KW - Parasites KW - Symptoms KW - Human diseases KW - Disease control KW - Malaria KW - Public health KW - Disease transmission KW - Demography KW - Insecticides KW - Feedback KW - Drugs KW - Mortality KW - Data processing KW - Motivation KW - Control programs KW - Anemia KW - Vectors KW - Plasmodium falciparum KW - Sepsis KW - Inoculation KW - Africa KW - National planning KW - Information systems KW - Hospitals KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Malaria+Surveillance+Counts&rft.au=Breman%2C+J+G%3BHolloway%2C+C+N&rft.aulast=Breman&rft.aufirst=J&rft.date=2007-12-01&rft.volume=77&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - SuppNotes - Special Issue: Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives. N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Symptoms; Parasites; Human diseases; Disease control; Malaria; Drugs; National planning; Disease transmission; Public health; Birth weight; Mortality; Data processing; Motivation; Control programs; Anemia; Vectors; Demography; Sepsis; Insecticides; Inoculation; Feedback; Hospitals; Information systems; Plasmodium falciparum; Africa ER - TY - JOUR T1 - Mononeme: A new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease AN - 20553260; 7937540 AB - Compartmentalization of proteins into subcellular organelles in eukaryotic cells is a fundamental mechanism of regulating complex cellular functions. Many proteins of Plasmodium falciparum merozoites involved in invasion are compartmentalized into apical organelles. We have identified a new merozoite organelle that contains P. falciparum rhomboid-1 (PfROM1), a protease that cleaves the transmembrane regions of proteins involved in invasion. By immunoconfocal microscopy, PfROM1 was localized to a single, thread-like structure on one side of the merozoites that appears to be in close proximity to the subpellicular microtubules. PfROM1 was not found associated with micronemes, rhoptries, or dense granules, the three identified secretory organelles of invasion. Release of merozoites from schizonts resulted in the movement of PfROM1 from the lateral asymmetric localization to the merozoite apical pole and the posterior pole. We have named this single thread-like organelle in merozoites, the mononeme. JF - Proceedings of the National Academy of Sciences, USA AU - Singh, Subhash AU - Plassmeyer, Matthew AU - Gaur, Deepak AU - Miller, Louis H AD - Malaria Cell Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 20043 EP - 20048 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 50 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Granules KW - Parasites KW - Microtubules KW - Human diseases KW - Schizonts KW - Malaria KW - Plasmodium falciparum KW - Public health KW - Micronemes KW - Microscopy KW - Merozoites KW - Proteinase KW - Organelles KW - K 03330:Biochemistry KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20553260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Mononeme%3A+A+new+secretory+organelle+in+Plasmodium+falciparum+merozoites+identified+by+localization+of+rhomboid-1+protease&rft.au=Singh%2C+Subhash%3BPlassmeyer%2C+Matthew%3BGaur%2C+Deepak%3BMiller%2C+Louis+H&rft.aulast=Singh&rft.aufirst=Subhash&rft.date=2007-12-01&rft.volume=104&rft.issue=50&rft.spage=20043&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Public health; Granules; Microtubules; Micronemes; Microscopy; Schizonts; Proteinase; Merozoites; Organelles; Plasmodium falciparum ER - TY - JOUR T1 - Lifestyle Factors and Incident Mobility Limitation in Obese and Non-obese Older Adults AN - 20536252; 8041718 AB - OBJECTIVE: This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults. RESEARCH METHODS AND PROCEDURES: Data were from men and women, 70 to 79 years of age from Pittsburgh, PA and Memphis, TN, participating in the Health, Aging and Body Composition (Health ABC) study. In addition to individual lifestyle practices, a high-risk lifestyle score (0 to 4) was calculated indicating the total number of unhealthy lifestyle practices per person. Mobility limitation was defined as reported difficulty walking 1/4 mile or climbing 10 steps during two consecutive semiannual assessments over 6.5 years. RESULTS: In non-obese older persons, significant risk factors for incident mobility limitation after adjustment for socio-demographics and health-related variables were current and former smoking [hazard ratio (HR) = 1.51; 95% confidence interval (CI), 1.20 to 1.89; HR = 1.40; 95% CI, 1.12 to 1.74), former alcohol intake (HR = 1.30; 95% CI, 1.05 to 1.60), low and medium physical activity (HR = 1.78; 95% CI, 1.45 to 2.18; HR = 1.29, 95% CI, 1.07 to 1.54), and eating an unhealthy diet (HR = 1.57; 95% CI, 1.17 to 2.10). In the obese, only low physical activity was associated with a significantly increased risk of mobility limitation (HR = 1.44; 95% CI, 1.08 to 1.92). Having two or more unhealthy lifestyle factors was a strong predictor of mobility limitation in the non-obese only (HR = 1.98; 95% CI, 1.61 to 2.43). Overall, obese persons had a significantly higher risk of mobility limitation compared with non-obese persons, independent of lifestyle factors (HR = 1.73; 95% CI, 1.52 to 1.96). CONCLUSIONS: These results underscore the importance of a healthy lifestyle for maintaining function among non-obese older adults. However, a healthy lifestyle cannot overcome the effect of obesity in obese older adults; this stresses the importance of preventing obesity to protect against mobility loss in older persons. JF - Obesity Research AU - Koster, Annemarie AU - Penninx, Brenda WJH AU - Newman, Anne B AU - Visser, Marjolein AU - van Gool, Coen H AU - Harris, Tamara B AU - van Eijk, Jacques ThM AU - Kempen, Gertrudis IJM AU - Brach, Jennifer S AU - Simonsick, Eleanor M AU - Houston, Denise K AU - Tylavsky, Frances A AU - Rubin, Susan M AU - Kritchevsky, Stephen B AD - Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands. Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland. Clinical Research Branch, National Institute on Aging, Baltimore, Maryland. Department of Psychiatry/Institute for Research in Extramural Medicine Institute, Vrije University Medical Center, Amsterdam, The Netherlands. Department of Epidemiology, Graduate School of Public Health, and. Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania. Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland. Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina. Department of Preventive Medi Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3122 EP - 3132 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 12 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Alcohol KW - Obesity KW - Eating disorders KW - Men KW - Women KW - Gerontology KW - Stress KW - Walking KW - Health KW - Exercise KW - Adults KW - Movement KW - Lifestyle KW - Evaluation KW - Smoking KW - Climbing KW - Risk factors KW - Diet KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Lifestyle+Factors+and+Incident+Mobility+Limitation+in+Obese+and+Non-obese+Older+Adults&rft.au=Koster%2C+Annemarie%3BPenninx%2C+Brenda+WJH%3BNewman%2C+Anne+B%3BVisser%2C+Marjolein%3Bvan+Gool%2C+Coen+H%3BHarris%2C+Tamara+B%3Bvan+Eijk%2C+Jacques+ThM%3BKempen%2C+Gertrudis+IJM%3BBrach%2C+Jennifer+S%3BSimonsick%2C+Eleanor+M%3BHouston%2C+Denise+K%3BTylavsky%2C+Frances+A%3BRubin%2C+Susan+M%3BKritchevsky%2C+Stephen+B&rft.aulast=Koster&rft.aufirst=Annemarie&rft.date=2007-12-01&rft.volume=15&rft.issue=12&rft.spage=3122&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lifestyle; Movement; Obesity; Gerontology; Adults; Health; Exercise; Diet; Alcohol; Smoking; Walking; Stress; Climbing; Women; Men; Risk factors; Body composition; Eating disorders; Evaluation ER - TY - JOUR T1 - A Phase I Trial of Lenalidomide in Patients with Recurrent Primary Central Nervous System Tumors AN - 20531592; 7933796 AB - PURPOSE: Inhibition of angiogenesis represents a promising new therapeutic strategy for treating primary malignant brain tumors. Lenalidomide, a potent analogue of the antiangiogenic agent thalidomide, has shown significant activity in several hematologic malignancies, and therefore we chose to explore its tolerability and activity in patients with primary central nervous system tumors. Experimental Design: A phase I interpatient dose escalation trial of lenalidomide in patients with recurrent primary central nervous system tumors was conducted. RESULTS: Thirty-six patients were accrued to the study, of which 28 were evaluable for toxicity, the primary end point of the trial. We show that lenalidomide can be given safely up to doses of 20 mg/m super(2), with the only toxicity being a probable increased risk of thromboembolic disease. Pharmacokinetic studies reveal good bioavailability, linear kinetics, and no effects of enzyme-inducing antiepileptic drugs on the metabolism of lenalidomide. No objective radiographic responses were seen in any of the treated patients. In the group of 24 patients with recurrent glioblastoma, the median time to tumor progression was <2 months and only 12.5% of patients were progression-free at 6 months. CONCLUSION: Lenalidomide is well tolerated in patients with recurrent glioma in doses up to 20 mg/m super(2). Treatment may be associated with an increased risk of thromboembolic disease. Preliminary data suggest that single agent activity may be limited in patients with recurrent glioblastoma at the doses evaluated although larger studies will be needed to confirm these observations. JF - Clinical Cancer Research AU - Fine, Howard A AU - Kim, Lyndon AU - Albert, Paul S AU - Duic, JPaul AU - Ma, Hilary AU - Zhang, Wei AU - Tohnya, Tanyifor AU - Figg, William D AU - Royce, Cheryl AD - Authors' Affiliations: Neuro-Oncology Branch and Medical Oncology Branch, National Cancer Institute Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7101 EP - 7106 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 23 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Glioblastoma KW - Central nervous system KW - antiangiogenic agents KW - Data processing KW - Thalidomide KW - Angiogenesis KW - Toxicity KW - Clinical trials KW - Pharmacokinetics KW - Thromboembolism KW - Brain tumors KW - Bioavailability KW - Malignancy KW - Kinetics KW - Glioma KW - Antiepileptic agents KW - Metabolism KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Phase+I+Trial+of+Lenalidomide+in+Patients+with+Recurrent+Primary+Central+Nervous+System+Tumors&rft.au=Fine%2C+Howard+A%3BKim%2C+Lyndon%3BAlbert%2C+Paul+S%3BDuic%2C+JPaul%3BMa%2C+Hilary%3BZhang%2C+Wei%3BTohnya%2C+Tanyifor%3BFigg%2C+William+D%3BRoyce%2C+Cheryl&rft.aulast=Fine&rft.aufirst=Howard&rft.date=2007-12-01&rft.volume=13&rft.issue=23&rft.spage=7101&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Glioblastoma; antiangiogenic agents; Data processing; Thalidomide; Angiogenesis; Toxicity; Clinical trials; Thromboembolism; Pharmacokinetics; Brain tumors; Bioavailability; Malignancy; Kinetics; Glioma; Antiepileptic agents; Metabolism ER - TY - JOUR T1 - Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex AN - 20520298; 8019398 AB - Type II dihydrofolate reductase (DHFR) is a plasmid-encoded enzyme that confers resistance to bacterial DHFR-targeted antifolate drugs. It forms a symmetric homotetramer with a central pore which functions as the active site. Its unusual structure, which results in a promiscuous binding surface that accommodates either the dihydrofolate (DHF) substrate or the NADPH cofactor, has constituted a significant limitation to efforts to understand its substrate specificity and reaction mechanism. We describe here the first structure of a ternary R67 DHFR super(.)DHF super(.)NADP super(+) catalytic complex, resolved to 1.26 Aa. This structure provides the first clear picture of how this enzyme, which lacks the active site carboxyl residue that is ubiquitous in Type I DHFRs, is able to function. In the catalytic complex, the polar backbone atoms of two symmetry-related I68 residues provide recognition motifs that interact with the carboxamide on the nicotinamide ring, and the N3-O4 amide function on the pteridine ring. This set of interactions orients the aromatic rings of substrate and cofactor in a relative endo geometry in which the reactive centers are held in close proximity. Additionally, a central, hydrogen-bonded network consisting of two pairs of Y69-Q67-Q67'-Y69' residues provides an unusually tight interface, which appears to serve as a "molecular clamp" holding the substrates in place in an orientation conducive to hydride transfer. In addition to providing the first clear insight regarding how this extremely unusual enzyme is able to function, the structure of the ternary complex provides general insights into how a mutationally challenged enzyme, i.e., an enzyme whose evolution is restricted to four-residues-at-a-time active site mutations, overcomes this fundamental limitation. JF - Biochemistry (Washington) AU - Krahn, Joseph M AU - Jackson, Michael R AU - DeRose, Eugene F AU - Howell, Elizabeth E AU - London, Robert E AD - Laboratory of Structural Biology, MR-01, National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Research Triangle Park, North Carolina 27709 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 14878 EP - 14888 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 46 IS - 51 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - nicotinamide KW - Substrate specificity KW - Enzymes KW - NADP KW - pteridine KW - Pores KW - Reaction mechanisms KW - Cofactors KW - Dihydrofolate reductase KW - Structure-function relationships KW - Crystal structure KW - amides KW - Mutation KW - Evolution KW - Aromatics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20520298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Crystal+Structure+of+a+Type+II+Dihydrofolate+Reductase+Catalytic+Ternary+Complex&rft.au=Krahn%2C+Joseph+M%3BJackson%2C+Michael+R%3BDeRose%2C+Eugene+F%3BHowell%2C+Elizabeth+E%3BLondon%2C+Robert+E&rft.aulast=Krahn&rft.aufirst=Joseph&rft.date=2007-12-01&rft.volume=46&rft.issue=51&rft.spage=14878&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701532rPII%3AS0006-2960%2870%2901532-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - nicotinamide; Enzymes; Substrate specificity; NADP; pteridine; Reaction mechanisms; Pores; Dihydrofolate reductase; Cofactors; Structure-function relationships; Crystal structure; Mutation; amides; Aromatics; Evolution DO - http://dx.doi.org/10.1021/bi701532rPII:S0006-2960(70)01532-5 ER - TY - JOUR T1 - Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group A Streptococcus AN - 20503057; 7982468 AB - Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS. JF - FEMS Microbiology Letters AU - Hoe, Nancy P AU - Lukomska, Ewa AU - Musser, James M AU - Lukomski, Slawomir AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, slukomski@hsc.wvu.edu Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 142 EP - 149 PB - Elsevier Science, P.O. Box 211 VL - 277 IS - 2 SN - 0378-1097, 0378-1097 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - group A Streptococcus KW - Scl KW - humoral response KW - Streptococcus KW - Serotypes KW - Peptide mapping KW - Antigenicity KW - Complications KW - Lymphocytes B KW - Pediatrics KW - Epitope mapping KW - Infection KW - Collagen KW - Antibodies KW - Immune response KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20503057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Characterization+of+the+immune+response+to+collagen-like+proteins+Scl1+and+Scl2+of+serotype+M1+and+M28+group+A+Streptococcus&rft.au=Hoe%2C+Nancy+P%3BLukomska%2C+Ewa%3BMusser%2C+James+M%3BLukomski%2C+Slawomir&rft.aulast=Hoe&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=277&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1111%2Fj.1574-6968.2007.00955.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Serotypes; Peptide mapping; Pediatrics; Lymphocytes B; Complications; Antigenicity; Epitope mapping; Immune response; Infection; Collagen; Streptococcus DO - http://dx.doi.org/10.1111/j.1574-6968.2007.00955.x ER - TY - JOUR T1 - Advances in fluorescent protein technology AN - 20502248; 7936322 AB - Current fluorescent protein (FP) development strategies are focused on fine-tuning the photophysical properties of blue to yellow variants derived from the Aequorea victoria jellyfish green fluorescent protein (GFP) and on the development of monomeric FPs from other organisms that emit in the yellow-orange to far-red regions of the visible light spectrum. Progress toward these goals has been substantial, and near-infrared emitting FPs may loom over the horizon. The latest efforts in jellyfish variants have resulted in new and improved monomeric BFP, CFP, GFP and YFP variants, and the relentless search for a bright, monomeric and fast-maturing red FP has yielded a host of excellent candidates, although none is yet optimal for all applications. Meanwhile, photoactivatable FPs are emerging as a powerful class of probes for intracellular dynamics and, unexpectedly, as useful tools for the development of superresolution microscopy applications. JF - Journal of Cell Science AU - Shaner, Nathan C AU - Patterson, George H AU - Davidson, Michael W AD - The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA. National High Magnetic Field Laboratory and Department of Biological Science, The Florida State University, Tallahassee, FL 32310, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 4247 EP - 4260 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 120 IS - 24 SN - 0021-9533, 0021-9533 KW - Biotechnology and Bioengineering Abstracts KW - Microscopy KW - Green fluorescent protein KW - Aequorea victoria KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20502248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=Advances+in+fluorescent+protein+technology&rft.au=Shaner%2C+Nathan+C%3BPatterson%2C+George+H%3BDavidson%2C+Michael+W&rft.aulast=Shaner&rft.aufirst=Nathan&rft.date=2007-12-01&rft.volume=120&rft.issue=24&rft.spage=4247&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Microscopy; Green fluorescent protein; Light effects; Aequorea victoria ER - TY - JOUR T1 - Anti-Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts AN - 20498866; 7933805 AB - PURPOSE: To determine the antitumor activity of the anti-mesothelin immunotoxin SS1P in combination with gemcitabine against mesothelin-expressing tumor xenografts. Experimental Design: The in vitro activity of SS1P in combination with gemcitabine against the mesothelin-expressing cell line A431/K5 was evaluated using cytotoxicity and apoptosis assays. The antitumor activity of this combination was evaluated in nude mice bearing A431/K5 tumor xenografts. Tumor-bearing mice were treated with different doses and schedules of gemcitabine alone, SS1P alone (0.2 mg/kg i.v. every other day x three doses), or with both agents together, and tumor volumes were measured over time. RESULTS: In vitro studies failed to show the synergy of SS1P plus gemcitabine against the mesothelin-expressing A431/K5 cells. In contrast, in the in vivo setting, there was a marked synergy when SS1P was combined with gemcitabine for the treatment of mesothelin-expressing tumor xenografts. This synergy was present using different doses and schedules of gemcitabine administration. In mice treated with fractionated doses of gemcitabine in combination with SS1P, complete tumor regression was observed in all mice and was long-lasting in 60% of the animals. Also, this antitumor activity was specific to SS1P because HA22, an immunotoxin targeting CD22 not expressed on A431/K5 cells, did not increase the efficacy of gemcitabine. CONCLUSIONS: SS1P in combination with gemcitabine results in marked antitumor activity against mesothelin-expressing tumors. This combination could be potentially useful for the treatment of human cancers that express mesothelin and are responsive to gemcitabine therapy. JF - Clinical Cancer Research AU - Hassan, Raffit AU - Broaddus, VCourtney AU - Wilson, Shannon AU - Liewehr, David J AU - Zhang, Jingli AD - Authors' Affiliations: Laboratory of Molecular Biology, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, and the Clinical Center, NIH, Bethesda, Maryland, and Lung Biology Center, San Francisco General Hospital, University of California, San Francisco, California Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7166 EP - 7171 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 23 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - CD22 antigen KW - Cytotoxicity KW - Apoptosis KW - gemcitabine KW - Tumors KW - Xenografts KW - Immunotoxins KW - Cancer KW - Antitumor activity KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20498866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Anti-Mesothelin+Immunotoxin+SS1P+in+Combination+with+Gemcitabine+Results+in+Increased+Activity+against+Mesothelin-Expressing+Tumor+Xenografts&rft.au=Hassan%2C+Raffit%3BBroaddus%2C+VCourtney%3BWilson%2C+Shannon%3BLiewehr%2C+David+J%3BZhang%2C+Jingli&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2007-12-01&rft.volume=13&rft.issue=23&rft.spage=7166&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; CD22 antigen; Apoptosis; gemcitabine; Xenografts; Tumors; Cancer; Immunotoxins; Antitumor activity ER - TY - JOUR T1 - Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA AN - 20468565; 7921519 AB - Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or individuals with predisposing risk factors. However, recently there has been an alarming epidemic caused by community-associated (CA)-MRSA strains, which can cause severe infections that can result in necrotizing fasciitis or even death in otherwise healthy adults outside of healthcare settings super(2). In the US, CA-MRSA is now the cause of the majority of infections that result in trips to the emergency room super(3). It is unclear what makes CA-MRSA strains more successful in causing human disease compared with their hospital- associated counterparts. Here we describe a class of secreted staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection. These peptides are produced at high concentrations by standard CA- MRSA strains and contribute significantly to the strains ability to cause disease in animal models of infection. Our study reveals a previously uncharacterized set of S. aureus virulence factors that account at least in part for the enhanced virulence of CA-MRSA. JF - Nature Medicine AU - Wang, Rong AU - Braughton, Kevin R AU - Kretschmer, Dorothee AU - Bach, Thanh-Huy L AU - Queck, Shu Y AU - Li, Min AU - Kennedy, Adam D AU - Dorward, David W AU - Klebanoff, Seymour J AU - Peschel, Andreas AU - DeLeo, Frank R AU - Otto, Michael Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1510 EP - 1514 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 13 IS - 12 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Epidemics KW - virulence factors KW - Drug resistance KW - Animal models KW - Leukocytes (neutrophilic) KW - Pathogens KW - Infection KW - Immunocompromised hosts KW - Necrotizing fasciitis KW - Risk factors KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Identification+of+novel+cytolytic+peptides+as+key+virulence+determinants+for+community-associated+MRSA&rft.au=Wang%2C+Rong%3BBraughton%2C+Kevin+R%3BKretschmer%2C+Dorothee%3BBach%2C+Thanh-Huy+L%3BQueck%2C+Shu+Y%3BLi%2C+Min%3BKennedy%2C+Adam+D%3BDorward%2C+David+W%3BKlebanoff%2C+Seymour+J%3BPeschel%2C+Andreas%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Wang&rft.aufirst=Rong&rft.date=2007-12-01&rft.volume=13&rft.issue=12&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1656 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epidemics; virulence factors; Risk factors; Necrotizing fasciitis; Immunocompromised hosts; Drug resistance; Leukocytes (neutrophilic); Animal models; Pathogens; Infection; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1038/nm1656 ER - TY - JOUR T1 - TAGster: efficient selection of LD tag SNPs in single or multiple populations AN - 20467736; 7929419 AB - SUMMARY: Genetic association studies increasingly rely on the use of linkage disequilibrium (LD) tag SNPs to reduce genotyping costs. We developed a software package TAGster to select, evaluate and visualize LD tag SNPs both for single and multiple populations. We implement several strategies to improve the efficiency of current LD tag SNP selection algorithms: (1) we modify the tag SNP selection procedure of Carlson et al. to improve selection efficiency and further generalize it to multiple populations. (2) We propose a redundant SNP elimination step to speed up the exhaustive tag SNP search algorithm proposed by Qin et al. (3) We present an additional multiple population tag SNP selection algorithm based on the framework of Howie et al., but using our modified exhaustive search procedure. We evaluate these methods using resequenced candidate gene data from the Environmental Genome Project and show improvements in both computational and tagging efficiency. AVAILABILITY: The software Package TAGster is freely available at http://www.niehs.nih.gov/research/resources/software/tagster/. Supplementary information: Additional information, including a tutorial, detailed algorithm and detailed evaluation results, is also available from TAGster web site (see above). JF - Bioinformatics AU - Xu, Zongli AU - Kaplan, Norman L AU - Taylor, Jack A AD - Epidemiology Branch, Biostatistics Branch and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, taylor@niehs.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 3254 EP - 3255 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 23 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Computer programs KW - Linkage disequilibrium KW - software KW - Single-nucleotide polymorphism KW - Genotyping KW - Algorithms KW - Bioinformatics KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20467736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=TAGster%3A+efficient+selection+of+LD+tag+SNPs+in+single+or+multiple+populations&rft.au=Xu%2C+Zongli%3BKaplan%2C+Norman+L%3BTaylor%2C+Jack+A&rft.aulast=Xu&rft.aufirst=Zongli&rft.date=2007-12-01&rft.volume=23&rft.issue=23&rft.spage=3254&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Linkage disequilibrium; Computer programs; software; Single-nucleotide polymorphism; Genotyping; Algorithms; Bioinformatics; Computer applications ER - TY - JOUR T1 - Dynamics of Escherichia coli Chromosome Segregation during Multifork Replication AN - 20467693; 7741951 AB - Slowly growing Escherichia coli cells have a simple cell cycle, with replication and progressive segregation of the chromosome completed before cell division. In rapidly growing cells, initiation of replication occurs before the previous replication rounds are complete. At cell division, the chromosomes contain multiple replication forks and must be segregated while this complex pattern of replication is still ongoing. Here, we show that replication and segregation continue in step, starting at the origin and progressing to the replication terminus. Thus, early-replicated markers on the multiple-branched chromosomes continue to separate soon after replication to form separate protonucleoids, even though they are not segregated into different daughter cells until later generations. The segregation pattern follows the pattern of chromosome replication and does not follow the cell division cycle. No extensive cohesion of sister DNA regions was seen at any growth rate. We conclude that segregation is driven by the progression of the replication forks. JF - Journal of Bacteriology AU - Nielsen, Henrik J AU - Youngren, Brenda AU - Hansen, Flemming G AU - Austin, Stuart AD - Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, CCR, NCI-Frederick, Frederick, Maryland 21702-1201. Microbial Genomics Group, Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8660 EP - 8666 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Growth rate KW - Chromosomes KW - Cell division KW - Replication initiation KW - Replication forks KW - Cell cycle KW - Escherichia coli KW - DNA KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20467693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Dynamics+of+Escherichia+coli+Chromosome+Segregation+during+Multifork+Replication&rft.au=Nielsen%2C+Henrik+J%3BYoungren%2C+Brenda%3BHansen%2C+Flemming+G%3BAustin%2C+Stuart&rft.aulast=Nielsen&rft.aufirst=Henrik&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8660&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Growth rate; Cell division; Chromosomes; Replication initiation; Replication forks; Cell cycle; DNA; Escherichia coli ER - TY - JOUR T1 - Vulnerability of the Orbitofrontal Cortex to Age-Associated Structural and Functional Brain Changes AN - 20464168; 9151047 AB - Abstract:Cross-sectional and longitudinal findings from the Baltimore Longitudinal Study of Aging (BLSA) neuroimaging study indicate that the orbitofrontal cortex (OFC) is among those regions vulnerable to age-associated tissue loss in older adults without dementia. Neuropathologic and recent in vivo amyloid imaging studies indicate that the OFC is also among the earliest neocortical regions to show deposition of amyloid plaques in aging and Alzheimer's disease. We performed behavioral and imaging studies to investigate age effects on specific aspects of OFC function. We compared performance in young (age 20-40) and old (age 60 and older) adults on cognitive tasks selected for differential sensitivity to OFC versus dorsolateral prefrontal cortex (DLPFC). Overall, greater age differences were seen in the OFC tasks compared to DLPFC tasks, with Delayed Match and Non-Match to Sample tasks showing the greatest effect size among OFC tasks and Self-Ordered Pointing Task showing the greatest effect size among DLPFC tasks. A functional magnetic resonance imaging study was conducted in parallel to probe the neural underpinnings of age differences in OFC function using the Delayed Match and Non-Match to Sample paradigm. Young but not old adults showed the expected OFC activation. Older compared with young adults showed greater activation in association with successful performance for several posterior regions, perhaps indicating compensation in the face of OFC deficits. Together, these findings indicate a vulnerability of the OFC to age-related decline in brain structure and function. Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes. JF - Annals of the New York Academy of Sciences AU - Resnick, Susan M AU - Lamar, Melissa AU - Driscoll, Ira AD - aIntramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 562 EP - 575 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1121 IS - 1 SN - 0077-8923, 0077-8923 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - orbitofrontal cortex KW - aging KW - cognition KW - MRI KW - longitudinal studies KW - Brain mapping KW - Neuroimaging KW - Age KW - Functional magnetic resonance imaging KW - Aging KW - Alzheimer's disease KW - Probes KW - USA, Maryland, Baltimore KW - young adults KW - Age differences KW - Cortex KW - Structure-function relationships KW - Dementia disorders KW - Geriatrics KW - Plaques KW - Sensitivity KW - Brain KW - Functional anatomy KW - Neurodegenerative diseases KW - Cognitive ability KW - Computed tomography KW - vulnerability KW - Cortex (prefrontal) KW - Amyloid KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20464168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Vulnerability+of+the+Orbitofrontal+Cortex+to+Age-Associated+Structural+and+Functional+Brain+Changes&rft.au=Resnick%2C+Susan+M%3BLamar%2C+Melissa%3BDriscoll%2C+Ira&rft.aulast=Resnick&rft.aufirst=Susan&rft.date=2007-12-01&rft.volume=1121&rft.issue=1&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1401.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Age; Neuroimaging; Functional magnetic resonance imaging; Alzheimer's disease; Aging; Probes; Functional anatomy; Age differences; Neurodegenerative diseases; Cortex; Structure-function relationships; Cognitive ability; Computed tomography; Dementia disorders; Geriatrics; Plaques; Cortex (prefrontal); Amyloid; Sensitivity; Brain; vulnerability; young adults; longitudinal studies; aging; USA, Maryland, Baltimore DO - http://dx.doi.org/10.1196/annals.1401.027 ER - TY - JOUR T1 - TOM1L1 Is a Lyn Substrate Involved in Fc epsilon RI Signaling in Mast Cells AN - 20455649; 7935177 AB - Protein-tyrosine kinase Lyn and Syk are critical for antigen-receptor-induced signal transduction in mast cells. To identify novel Lyn/Syk substrates, we screened an RBL-2H3 bacterial expression library for proteins that were tyrosine phosphorylated with baculoviral expressed Lyn or Syk. Five clones as potential Lyn substrates and eight clones as Syk substrates were identified including known substrates such as SLP-76, LAT, and alpha -tubulin. A potential substrate of Lyn identified was the molecule TOM1L1, which has several domains thought to be important for membrane trafficking and protein-protein interactions. Because the function of TOM1L1 is unclear, the rat TOM1L1 full-length cDNA was isolated and used to express the protein in COS-1 and RBL-2H3 mast cells. In COS-1 cells, the co-transfection of TOM1L1 and Lyn, but not Syk, resulted in the tyrosine phosphorylation of TOM1L1. In RBL-2H3 mast cells, the overexpressed TOM1L1 was strongly tyrosine phosphorylated in non-stimulated cells, and this phosphorylation was enhanced by Fc epsilon RI aggregation. By subcellular fractionation, wild-type TOM1L1 was mainly in the cytoplasm with a small fraction constitutively associated with the membrane; this association was markedly reduced in deletion mutants lacking several of the protein interaction domains. The overexpression of TOM1L1 enhanced antigen-induced tumor necrosis factor (TNF) alpha generation and release. Both protein interaction domains (VHS and the coiled-coil domains) were required for the increased TNF alpha release, but not the increased TNF alpha generation. These results suggest that TOM1L1 is a novel protein involved in the Fc epsilon RI signal transduction for the generation of cytokines. JF - Journal of Biological Chemistry AU - Zhang, Juan AU - Suzuki, Katsuhiro AU - Hitomi, Tomohiro AU - Siraganian, Reuben P AD - Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37669 EP - 37677 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 52 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Deletion mutant KW - double prime Fc receptors KW - SLP-76 protein KW - Tumor necrosis factor KW - Mast cells KW - Tyrosine KW - Syk protein KW - Phosphorylation KW - Cytoplasm KW - Protein-tyrosine kinase KW - membrane trafficking KW - Cytokines KW - Tumor necrosis factor- alpha KW - Tubulin KW - Protein interaction KW - Lyn protein KW - Signal transduction KW - J 02320:Cell Biology KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=TOM1L1+Is+a+Lyn+Substrate+Involved+in+Fc+epsilon+RI+Signaling+in+Mast+Cells&rft.au=Zhang%2C+Juan%3BSuzuki%2C+Katsuhiro%3BHitomi%2C+Tomohiro%3BSiraganian%2C+Reuben+P&rft.aulast=Zhang&rft.aufirst=Juan&rft.date=2007-12-01&rft.volume=282&rft.issue=52&rft.spage=37669&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Deletion mutant; double prime Fc receptors; Tumor necrosis factor; SLP-76 protein; Tyrosine; Mast cells; Syk protein; Phosphorylation; Cytoplasm; Protein-tyrosine kinase; membrane trafficking; Cytokines; Tumor necrosis factor- alpha; Tubulin; Lyn protein; Protein interaction; Signal transduction ER - TY - JOUR T1 - Human Islet-Derived Precursor Cells Are Mesenchymal Stromal Cells That Differentiate and Mature to Hormone-Expressing Cells In Vivo AN - 20451271; 7938055 AB - Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise for cell therapy because they can expand before differentiation to produce a large supply of functional insulin-producing cells. Previously, we described proliferative populations of human islet-derived precursor cells (hIPCs) from adult islets. To show the differentiation potential of hIPCs, which do not express insulin mRNA after at least 1,000-fold expansion, we generated epithelial cell clusters (ECCs) during 4 days of differentiation in vitro. After transplantation into mice, 22 of 35 ECC preparations differentiated and matured into functional cells that secreted human C-peptide in response to glucose. Transcripts for insulin, glucagon, and somatostatin in recovered ECC grafts increased with time in vivo, reaching levels approximately 1% of those in adult islets. We show that hIPCs are mesenchymal stromal cells (MSCs) that adhere to plastic, express CD73, CD90, and CD105, and can differentiate in vitro into adipocytes, chondrocytes, and osteocytes. Moreover, we find a minor population of CD105 super(+)/CD73 super(+)/CD90 super(+) cells in adult human islets (prior to incubation in vitro) that express insulin mRNA at low levels. We conclude that hIPCs are a specific type of pancreas-derived MSC that are capable of differentiating into hormone-expressing cells. Their ability to mature into functional insulin-secreting cells in vivo identifies them as an important adult precursor or stem cell population that could offer a virtually unlimited supply of human islet-like cells for replacement therapy in type 1 diabetes. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Davani, Behrous AU - Ikonomou, Laertis AU - Raaka, Bruce M AU - Geras-Raaka, Elizabeth AU - Morton, Russell A AU - Marcus-Samuels, Bernice AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3215 EP - 3222 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Donors KW - CD105 antigen KW - stromal cells KW - Pancreas KW - Glucagon KW - Glucose KW - Chondrocytes KW - Islets of Langerhans KW - Homeostasis KW - Osteocytes KW - Insulin KW - Somatostatin KW - Diabetes mellitus KW - Differentiation KW - Stem cells KW - CD90 antigen KW - Adipocytes KW - Allografts KW - CD73 antigen KW - Pancreatic islet transplantation KW - Plastics KW - Mesenchyme KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Human+Islet-Derived+Precursor+Cells+Are+Mesenchymal+Stromal+Cells+That+Differentiate+and+Mature+to+Hormone-Expressing+Cells+In+Vivo&rft.au=Davani%2C+Behrous%3BIkonomou%2C+Laertis%3BRaaka%2C+Bruce+M%3BGeras-Raaka%2C+Elizabeth%3BMorton%2C+Russell+A%3BMarcus-Samuels%2C+Bernice%3BGershengorn%2C+Marvin+C&rft.aulast=Davani&rft.aufirst=Behrous&rft.date=2007-12-01&rft.volume=25&rft.issue=12&rft.spage=3215&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Donors; CD105 antigen; stromal cells; Glucagon; Pancreas; Glucose; Chondrocytes; Islets of Langerhans; Homeostasis; Osteocytes; Somatostatin; Insulin; Diabetes mellitus; Differentiation; Stem cells; Adipocytes; CD90 antigen; Allografts; Plastics; Pancreatic islet transplantation; CD73 antigen; Mesenchyme ER - TY - JOUR T1 - CT Colonography with Computer-aided Detection as a Second Reader: Observer Performance Study AN - 20451132; 7937808 AB - PURPOSE: To evaluate the effect of computer-aided detection (CAD) as second reader on radiologists' diagnostic performance in interpreting computed tomographic (CT) colonographic examinations by using a primary two-dimensional (2D) approach, with segmental, unblinded optical colonoscopy as the reference standard. MATERIALS AND METHODS: This HIPAA-compliant study was IRB-approved with written informed consent. Four board-certified radiologists analyzed 60 CT examinations with a commercially available review system. Two-dimensional transverse views were used for initial polyp detection, while three-dimensional (3D) endoluminal and 2D multiplanar views were available for problem solving. After initial review without CAD, the reader was shown CAD-identified polyp candidates. The readers were then allowed to add to or modify their original diagnoses. Polyp location, CT Colonography Reporting and Data System categorization, and reader confidence as to the likelihood of a candidate being a polyp were recorded before and after CAD reading. The area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, and specificity were estimated for CT examinations with and without CAD readings by using multireader multicase analysis. RESULTS: Use of CAD led to nonsignificant average reader AUC increases of 0.03, 0.03, and 0.04 for patients with adenomatous polyps 6 mm or larger, 6-9 mm, and 10 mm or larger, respectively (P greater than or equal to .25); likewise, CAD increased average reader sensitivity by 0.15, 0.16, and 0.14 for those respective groups, with a corresponding decrease in specificity of 0.14. These changes achieved significance for the 6 mm or larger group (P .16). The average reading time was 5.1 minutes plus or minus 3.4 (standard deviation) without CAD. CAD added an average of 3.1 minutes plus or minus 4.3 (62%) to each reading (supine and prone positions combined); average total reading time, 8.2 minutes plus or minus 5.8. CONCLUSION: Use of CAD led to a significant increase in sensitivity for detecting polyps in the 6 mm or larger and 6-9 mm groups at the expense of a similar significant reduction in specificity. [copy ] RSNA, 2007 JF - Radiology AU - Petrick, Nicholas AU - Haider, Maruf AU - Summers, Ronald M AU - Yeshwant, Srinath C AU - Brown, Linda AU - Iuliano, Edward M AU - Louie, Adeline AU - Choi, JRichard AU - Pickhardt, Perry J AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C351, Bethesda, MD 20892-1182 (M.H., R.M.S., S.C.Y., L.B., A.L.) Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 148 EP - 156 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 246 IS - 1 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Standard deviation KW - Computed tomography KW - Problem solving KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=CT+Colonography+with+Computer-aided+Detection+as+a+Second+Reader%3A+Observer+Performance+Study&rft.au=Petrick%2C+Nicholas%3BHaider%2C+Maruf%3BSummers%2C+Ronald+M%3BYeshwant%2C+Srinath+C%3BBrown%2C+Linda%3BIuliano%2C+Edward+M%3BLouie%2C+Adeline%3BChoi%2C+JRichard%3BPickhardt%2C+Perry+J&rft.aulast=Petrick&rft.aufirst=Nicholas&rft.date=2007-12-01&rft.volume=246&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Standard deviation; Computed tomography; Problem solving; Polyps ER - TY - JOUR T1 - New inhibitors of ABCG2 identified by high-throughput screening AN - 20446894; 7936729 AB - In order to identify novel inhibitors of the ATP-binding cassette transporter, ABCG2, a high-throughput assay measuring the accumulation of the ABCG2 substrate pheophorbide a in ABCG2-overexpressing NCI-H460 MX20 cells was used to screen libraries of compounds. Out of a library of 7,325 natural products and synthetic compounds from the National Cancer Institute/Developmental Therapeutics Program collection, 18 were found to inhibit ABCG2 at 10 mu mol/L. After eliminating flavonoids and compounds of limited availability from the 18 original compounds, 10 of the 11 remaining compounds reversed mitoxantrone resistance in NCI-H460/MX20 cells and prevented ABCG2-mediated BODIPY-prazosin transport in ABCG2-transfected HEK293 cells, confirming an interaction with ABCG2. Based on the activity profiles and the availability of materials, five inhibitors were examined for their ability to compete with [ super(125)I]iodoarylazidoprazosin labeling of ABCG2, increase binding of the anti-ABCG2 antibody 5D3, and prevent P-glycoprotein or multidrug resistance protein 1-mediated transport. At a concentration of 20 mu mol/L, all of the compounds reduced iodoarylazidoprazosin labeling by 50% to 80% compared with controls. All five compounds also increased 5D3 labeling of ABCG2, indicating that these compounds are inhibitors but not substrates of ABCG2. None of the compounds affected P-glycoprotein-mediated rhodamine 123 transport, whereas three affected multidrug resistance protein-1-mediated calcein transport at 25 mu mol/L, suggesting that the compounds are relatively specific for ABCG2. These five novel inhibitors of ABCG2 activity may provide a basis for further investigation of ABCG2 function and its relevance in multidrug resistance. [Mol Cancer Ther 2007; 6(12):3271-8] JF - Molecular Cancer Therapeutics AU - Henrich, Curtis J AU - Robey, Robert W AU - Bokesch, Heidi R AU - Bates, Susan E AU - Shukla, Suneet AU - Ambudkar, Suresh V AU - Dean, Michael AU - McMahon, James B AD - Basic Research Program, SAIC-Frederick, Inc., Molecular Targets Development Program, and Laboratory of Genomic Diversity, NCI Frederick, Frederick, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3271 EP - 3278 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biotechnology Research Abstracts (through 1992) KW - Protein transport KW - Flavonoids KW - Calcein KW - natural products KW - Cancer KW - Antibodies KW - P-Glycoprotein KW - ATP-binding protein KW - high-throughput screening KW - Multidrug resistance KW - rhodamine KW - mitoxantrone KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20446894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=New+inhibitors+of+ABCG2+identified+by+high-throughput+screening&rft.au=Henrich%2C+Curtis+J%3BRobey%2C+Robert+W%3BBokesch%2C+Heidi+R%3BBates%2C+Susan+E%3BShukla%2C+Suneet%3BAmbudkar%2C+Suresh+V%3BDean%2C+Michael%3BMcMahon%2C+James+B&rft.aulast=Henrich&rft.aufirst=Curtis&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3271&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Multidrug resistance; mitoxantrone; natural products; P-Glycoprotein; Antibodies; Flavonoids; Calcein; Cancer; ATP-binding protein; rhodamine; high-throughput screening; Protein transport ER - TY - JOUR T1 - Evaluation of a Novel PCR-Based Assay for Detection and Identification of Chlamydia trachomatis Serovars in Cervical Specimens AN - 20441682; 7935566 AB - The aims of this study were to compare a novel PCR-based Chlamydia trachomatis detection and genotyping (Ct-DT) assay with the FDA-approved, commercially available C. trachomatis detection Hybrid Capture 2 (HC2) assay and to investigate the C. trachomatis serovar distribution among young women in a rural Costa Rican study population. A total of 5,828 sexually active women participating in a community-based trial in Costa Rica were tested for C. trachomatis by HC2. A sample of 1,229 specimens consisting of 100% HC2 C. trachomatis-positive specimens (n = 827) and a random sample of 8% HC2 C. trachomatis-negative specimens (n = 402) were tested with the Ct-DT assay. Agreement between the two assays was determined by the unweighted kappa statistic. Discrepant specimens were tested with a second commercially available test (COBAS TaqMan). The Ct-DT-positive specimens were further analyzed with the Ct-DT genotyping step to investigate the distribution of 14 different C. trachomatis serovars (A, B/Ba, C, D/Da, E, F, G/Ga, H, I/Ia, J, K, L1, L2/L2a, and L3). After accounting for the sampling fraction selected for Ct-DT testing, crude agreement with the HC2 assay was 98% and the kappa was 0.92 (95% confidence interval [CI], 0.89 to 0.97). The 33 discordant samples that were further analyzed with the COBAS TaqMan test showed better agreement with the Ct-DT assay (31/33, P < 0.001). Among the 806 Ct-DT-positive samples, serovar E was the most common serovar (31%), followed by serovars F and D (both 21%) and serovar I (15%). In conclusion, the novel Ct-DT assay permits reliable detection and identification of C. trachomatis serovars. JF - Journal of Clinical Microbiology AU - Quint, Koen AU - Porras, Carolina AU - Safaeian, Mahboobeh AU - Gonzalez, Paula AU - Hildesheim, Allan AU - Quint, Wim AU - van Doorn, Leen-Jan AU - Silva, Sandra AU - Melchers, Willem AU - Schiffman, Mark AU - Rodriguez, Ana Cecilia AU - Wacholder, Sholom AU - Freer, Enrique AU - Cortes, Bernal AU - Herrero, Rolando AD - DDL Diagnostic Laboratory, Voorburg, The Netherlands. Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. Centro de Investigacion Estructuras Microscopicas, Universidad de Costa Rica, San Jose, Costa Rica. Department of Medical Microbiology, Medical Centre, Radboud University Nijmegen, Nijmegen, The Netherlands Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3986 EP - 3991 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genotyping KW - Hybrids KW - Chlamydia trachomatis KW - Population studies KW - Sampling KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20441682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+a+Novel+PCR-Based+Assay+for+Detection+and+Identification+of+Chlamydia+trachomatis+Serovars+in+Cervical+Specimens&rft.au=Quint%2C+Koen%3BPorras%2C+Carolina%3BSafaeian%2C+Mahboobeh%3BGonzalez%2C+Paula%3BHildesheim%2C+Allan%3BQuint%2C+Wim%3Bvan+Doorn%2C+Leen-Jan%3BSilva%2C+Sandra%3BMelchers%2C+Willem%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana+Cecilia%3BWacholder%2C+Sholom%3BFreer%2C+Enrique%3BCortes%2C+Bernal%3BHerrero%2C+Rolando&rft.aulast=Quint&rft.aufirst=Koen&rft.date=2007-12-01&rft.volume=45&rft.issue=12&rft.spage=3986&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hybrids; Genotyping; Population studies; Sampling; Clinical trials; Chlamydia trachomatis ER - TY - JOUR T1 - Variations in Phytoestrogen Content between Different Mill Dates of the Same Diet Produces Significant Differences in the Time of Vaginal Opening in CD-1 Mice and F344 Rats but Not in CD Sprague-Dawley Rats AN - 20418814; 7828246 AB - BACKGROUND: The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical. Objectives: We conducted studies to evaluate rodent species sensitivity and the effects of diets varying in phytoestrogen content on the time of vaginal opening (VO) in CD-1 mice, Fischer 344 (F344) rats, and CD Sprague-Dawley (S-D) rats. METHODS: Mice were weaned on postnatal day (PND) 15 and rats on PND 19 and randomly assigned to control or test diets. Body weights, food consumption, and time of VO were recorded. RESULTS: The time of VO was significantly advanced in F344 rats fed diets containing daidzein and genistein, whereas these same diets did not advance VO in S-D rats. When animals were fed the AIN-76A diet spiked with genistein, time of VO was significantly advanced at all doses in CD-1 mice, at the two highest doses in F344 rats, and at the highest dose in S-D rats. The time of VO in F344 rats was more highly correlated with the phytoestrogen content than with the total metaboliz-able energy (ME) of 12 diets. CONCLUSIONS: The S-D rat is less sensitive to dietary phytoestrogens compared with the F344 rat or the CD-1 mouse, suggesting that the S-D rat is not the ideal model for evaluating estrogenic activity of EDCs. The profound effects of dietary phytoestrogens on the time of VO, an estrogen-sensitive marker, indicate that a standardized open-formula phytoestrogen-free diet containing a low ME level should be used to optimize the sensitivity of estrogenic bioassays. JF - Environmental Health Perspectives AU - Thigpen, JE AU - Setchell, KDR AU - Padilla-Banks, E AU - Haseman, J K AU - Saunders, HE AU - Caviness, G F AU - Kissling, GE AU - Grant, M G AU - Forsythe, D B AD - Quality Assurance Laboratory, Comparative Medicine Branch, National Institute of Environmental Health Sciences, P.O.Box 12233, Mail Drop C1-06, Research Triangle Park, NC 27709 USA, thigpen@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1717 EP - 1726 VL - 115 IS - 12 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Diets KW - Food consumption KW - Nutrient deficiency KW - Body weight KW - Endocrine disruptors KW - Energy KW - Vagina KW - Phytoestrogens KW - estrogenic activity KW - Genistein KW - daidzein KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Variations+in+Phytoestrogen+Content+between+Different+Mill+Dates+of+the+Same+Diet+Produces+Significant+Differences+in+the+Time+of+Vaginal+Opening+in+CD-1+Mice+and+F344+Rats+but+Not+in+CD+Sprague-Dawley+Rats&rft.au=Thigpen%2C+JE%3BSetchell%2C+KDR%3BPadilla-Banks%2C+E%3BHaseman%2C+J+K%3BSaunders%2C+HE%3BCaviness%2C+G+F%3BKissling%2C+GE%3BGrant%2C+M+G%3BForsythe%2C+D+B&rft.aulast=Thigpen&rft.aufirst=JE&rft.date=2007-12-01&rft.volume=115&rft.issue=12&rft.spage=1717&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Food consumption; Nutrient deficiency; Body weight; Energy; Endocrine disruptors; Vagina; Phytoestrogens; estrogenic activity; Genistein; daidzein DO - http://dx.doi.org/10.1289/ehp.10165 ER - TY - JOUR T1 - A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains AN - 20375725; 7744185 AB - A monoclonal Fab (Fab 3674) selected from a human nonimmune phage library by panning against the chimeric construct N sub(CCG)-gp41 (which comprises an exposed coiled-coil trimer of gp41 N helices fused in the helical phase onto the minimal thermostable ectodomain of gp41) is described. Fab 3674 is shown to neutralize diverse laboratory-adapted B strains of human immunodeficiency virus type 1 (HIV-1) and primary isolates of subtypes A, B, and C in an Env-pseudotyped-virus neutralization assay, albeit with reduced potency (approximately 25-fold) compared to that of 2F5 and 4E10. Alanine scanning mutagenesis maps a novel epitope to a shallow groove on the N helices of gp41 that is exposed between two C helices in the fusogenic six-helix bundle conformation of gp41. Bivalent Fab 3674 and the C34 peptide (a potent fusion inhibitor derived from the C helix of gp41) are shown to act at similar stages of the fusion reaction and to neutralize HIV-1 synergistically, providing additional evidence that the epitope of Fab 3674 is new and distinct from the binding site of C34. JF - Journal of Virology AU - Gustchina, Elena AU - Louis, John M AU - Lam, Son N AU - Bewley, Carole A AU - Clore, GMarius AD - Laboratories of Chemical Physics. Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 12946 EP - 12953 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 23 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Phages KW - Human immunodeficiency virus 1 KW - Epitopes KW - glycoprotein gp41 KW - Panning KW - Scanning mutagenesis KW - Fab KW - Conformation KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A+Monoclonal+Fab+Derived+from+a+Human+Nonimmune+Phage+Library+Reveals+a+New+Epitope+on+gp41+and+Neutralizes+Diverse+Human+Immunodeficiency+Virus+Type+1+Strains&rft.au=Gustchina%2C+Elena%3BLouis%2C+John+M%3BLam%2C+Son+N%3BBewley%2C+Carole+A%3BClore%2C+GMarius&rft.aulast=Gustchina&rft.aufirst=Elena&rft.date=2007-12-01&rft.volume=81&rft.issue=23&rft.spage=12946&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; glycoprotein gp41; Fab; Epitopes; Phages; Panning; Conformation; Scanning mutagenesis ER - TY - JOUR T1 - Replicating and non-replicating viral vectors for vaccine development AN - 20264575; 8853250 AB - Viral vectors provide a convenient means to deliver vaccine antigens to select target cells or tissues. A broad spectrum of replicating and non- replicating vectors is available. An appropriate choice for select applications will depend on the biology of the infectious agent targeted, as well as factors such as whether the vaccine is intended to prevent infection or boost immunity in already infected individuals, prior exposure of the target population to the vector, safety, and the number and size of gene inserts needed. Here several viral vectors under development as HIV/AIDS vaccines are reviewed. A vaccine strategy based on initial priming with a replicating vector to enlist the innate immune system, target mucosal inductive sites, and prime both cellular and humoral systemic and mucosal immune responses is proposed. Subsequently, boosting with a replicating or non-replicating vector and/or protein subunits could lead to induction of necessary levels of protective immunity. JF - Current Opinion in Biotechnology AU - Robert-Guroff, Marjorie AD - National Institutes of Health, National Cancer Institute, Vaccine Branch, 41 Medlars Drive, Building 41, Room D804, Bethesda, MD 20892-5065, United States, guroffm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 546 EP - 556 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 6 SN - 0958-1669, 0958-1669 KW - Virology & AIDS Abstracts; Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Mucosal immunity KW - Human immunodeficiency virus KW - Reviews KW - Vaccines KW - Immunity KW - Infection KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20264575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Replicating+and+non-replicating+viral+vectors+for+vaccine+development&rft.au=Robert-Guroff%2C+Marjorie&rft.aulast=Robert-Guroff&rft.aufirst=Marjorie&rft.date=2007-12-01&rft.volume=18&rft.issue=6&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Mucosal immunity; Reviews; Immunity; Vaccines; Infection; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.copbio.2007.10.010 ER - TY - JOUR T1 - Visualization and experimental analysis of blood vessel formation using transgenic zebrafish AN - 20256881; 8891551 AB - The mechanisms of blood vessel formation have become a subject of enormous scientific and clinical interest. However, it is difficult to visualize the developing vasculature in most living animals due to the ubiquitous and deep localization of vessels within other tissues. The establishment of vascular-specific transgenic zebrafish with fluorescently tagged blood vessels has facilitated high-resolution imaging studies of developing blood and lymphatic vessels in vivo. Use of these transgenic lines for genetic and chemical screening, experimental manipulations, and time-lapse imaging has extended our knowledge of how complex networks of vessels assemble in vivo. Birth Defects Research (Part C) 81:286-296, 2007. Published 2008 Wiley-Liss, Inc. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Cha, Young Ryun AU - Weinstein, Brant M AD - Laboratory of Molecular Genetics, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, WeinsteB@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 286 EP - 296 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 81 IS - 4 SN - 1542-975X, 1542-975X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Danio rerio KW - Blood vessels KW - Congenital defects KW - Embryos KW - imaging KW - Lymphatic system KW - W 30910:Imaging KW - G 07840:Fish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20256881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Visualization+and+experimental+analysis+of+blood+vessel+formation+using+transgenic+zebrafish&rft.au=Cha%2C+Young+Ryun%3BWeinstein%2C+Brant+M&rft.aulast=Cha&rft.aufirst=Young&rft.date=2007-12-01&rft.volume=81&rft.issue=4&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood vessels; Congenital defects; Embryos; imaging; Lymphatic system; Danio rerio DO - http://dx.doi.org/10.1002/bdrc.20103 ER - TY - JOUR T1 - Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells AN - 20194848; 7786172 AB - The advent of hybridoma technology has made it possible to study in-depth individual antibody molecules. These studies have revealed a number of surprises that have and are continuing to change our view of the immune system. None of these was more surprising than the demonstration that many antibody molecules are polyreactive - that is they can bind to a variety of different and structurally unrelated self- and non-self-foreign antigens. These findings make it clear that self-reactivity is a common and not necessarily forbidden or pathogenic feature of the immune system and that the well-known broad antibacterial activity of natural antibodies is largely due to polyreactive antibodies. In this brief review we will discuss these insights and their impact on basic and clinical immunology. JF - Journal of Autoimmunity AU - Zhou, Z H AU - Tzioufas, A G AU - Notkins, AL AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 106, 30 Convent Dr., MSC 4322, Bethesda, MD 20892-4322, USA, anotkins@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 219 EP - 228 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 29 IS - 4 SN - 0896-8411, 0896-8411 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Hybridoma KW - Antibodies KW - Antibacterial activity KW - Lymphocytes B KW - Immune system KW - Reviews KW - F 06930:Autoimmunity KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20194848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autoimmunity&rft.atitle=Properties+and+function+of+polyreactive+antibodies+and+polyreactive+antigen-binding+B+cells&rft.au=Zhou%2C+Z+H%3BTzioufas%2C+A+G%3BNotkins%2C+AL&rft.aulast=Zhou&rft.aufirst=Z&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autoimmunity&rft.issn=08968411&rft_id=info:doi/10.1016%2Fj.jaut.2007.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hybridoma; Antibodies; Antibacterial activity; Lymphocytes B; Reviews; Immune system DO - http://dx.doi.org/10.1016/j.jaut.2007.07.015 ER - TY - JOUR T1 - Effect of Sexually Transmitted Disease (STD) Coinfections on Performance of Three Commercially Available Immunosorbent Assays Used for Detection of Herpes Simplex Virus Type 2-Specific Antibody in Men Attending Baltimore, Maryland, STD Clinics AN - 20100447; 7933543 AB - Two hundred seventy-nine serum samples from men attending sexually transmitted disease (STD) clinics in Baltimore, Maryland, were tested for herpes simplex virus type 2 (HSV-2)-specific antibody by three immunosorbent glycoprotein G-2-based assays (the Kalon, Focus, and Biokit assays). The results for all samples with positive results were confirmed by Western blotting (91/279; 32.6% HSV-2 seroprevalence). All patients were also tested for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, human immunodeficiency virus type 1, and hepatitis C virus. The Kalon assay performed very well with samples from this population (90.8% sensitive, 99.4% specific), whereas the Focus assay had a sensitivity (82.6%) much lower than that shown previously. For 19.7% of the samples, the Biokit assay gave an indeterminate result. It was found that the odds of a sample having a Biokit assay indeterminate result compared to that of having a definitive positive or negative results were 3.88 times greater for subjects concurrently infected with N. gonorrhoeae, after the effects of other STDs were controlled for (P = 0.001; 95% confidence interval, 1.78, 8.45). Unfortunately, we were unable to control for HSV-1 infection status in the regression model, which, on the basis of chi super(2) analysis, might also affect the clarity of the Biokit test. The recommended index cutoff value of 1.1 for the Focus and Kalon assays was found to be optimal for this population. JF - Clinical and Vaccine Immunology AU - Summerton, Jean AU - Riedesel, Melissa AU - Laeyendecker, Oliver AU - Gaydos, Charlotte AU - Maldeis, Nancy E AU - Hardick, Andrew AU - Morrow, Rhoda Ashley AU - Quinn, Thomas C AD - The Johns Hopkins University, School of Medicine, Division of Infectious Diseases, Baltimore, Maryland. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Laboratory Medicine, University of Washington, Seattle, Washington Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1545 EP - 1549 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 14 IS - 12 SN - 1556-6811, 1556-6811 KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Western blotting KW - Trichomonas vaginalis KW - Sexually-transmitted diseases KW - Mycoplasma genitalium KW - Herpes simplex virus 1 KW - Chlamydia trachomatis KW - Herpes simplex virus 2 KW - Infection KW - Neisseria gonorrhoeae KW - Immunosorbents KW - Models KW - Antibodies KW - Hepatitis C virus KW - Human immunodeficiency virus 1 KW - Regression analysis KW - Glycoproteins KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20100447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Effect+of+Sexually+Transmitted+Disease+%28STD%29+Coinfections+on+Performance+of+Three+Commercially+Available+Immunosorbent+Assays+Used+for+Detection+of+Herpes+Simplex+Virus+Type+2-Specific+Antibody+in+Men+Attending+Baltimore%2C+Maryland%2C+STD+Clinics&rft.au=Summerton%2C+Jean%3BRiedesel%2C+Melissa%3BLaeyendecker%2C+Oliver%3BGaydos%2C+Charlotte%3BMaldeis%2C+Nancy+E%3BHardick%2C+Andrew%3BMorrow%2C+Rhoda+Ashley%3BQuinn%2C+Thomas+C&rft.aulast=Summerton&rft.aufirst=Jean&rft.date=2007-12-01&rft.volume=14&rft.issue=12&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Antibodies; Sexually-transmitted diseases; Regression analysis; Glycoproteins; Infection; Immunosorbents; Models; Trichomonas vaginalis; Hepatitis C virus; Mycoplasma genitalium; Human immunodeficiency virus 1; Herpes simplex virus 1; Chlamydia trachomatis; Herpes simplex virus 2; Neisseria gonorrhoeae ER - TY - JOUR T1 - Stem cells: Current challenges and future promise AN - 20005183; 7760795 AB - Stem cells have two remarkable properties. They can either renew themselves or they can differentiate into one or more adult cell types. Stem cells derived from a human embryo appear to have an unlimited capacity to self-renew in cell culture, and they are also able to differentiate into hundreds of adult cell types. Human embryonic stem cell lines offer a platform technology that has the potential to elucidate the molecular mechanisms that determine adult cell fate, generate cellular models for discovery of new drugs, and create populations of differentiated cells for novel transplantation therapies. The National Institutes of Health (NIH) has identified some of the rate-limiting steps toward realizing this potential, and has forged funding initiatives to accelerate research progress. Given the remarkable potential, NIH support for research using stem cells is an important priority for the foreseeable future. JF - Developmental Dynamics AU - Battey, James F AD - National Institutes of Health, Bethesda, Maryland, batteyj@nidcd.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3193 EP - 3198 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 236 IS - 12 SN - 1058-8388, 1058-8388 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Drug discovery KW - Stem cells KW - Embryo cells KW - Cell culture KW - Cell fate KW - Immunosuppressive agents KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20005183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Dynamics&rft.atitle=Stem+cells%3A+Current+challenges+and+future+promise&rft.au=Battey%2C+James+F&rft.aulast=Battey&rft.aufirst=James&rft.date=2007-12-01&rft.volume=236&rft.issue=12&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Developmental+Dynamics&rft.issn=10588388&rft_id=info:doi/10.1002%2Fdvdy.21203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug discovery; Molecular modelling; Stem cells; Embryo cells; Cell culture; Cell fate; Immunosuppressive agents DO - http://dx.doi.org/10.1002/dvdy.21203 ER - TY - JOUR T1 - The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression AN - 19993678; 7938056 AB - Human islet-derived precursor cells (hIPCs), mesenchymal cells derived in vitro from adult pancreas, proliferate freely and do not express insulin but can be differentiated to epithelial cells that express insulin. hIPCs have been studied with the goal of obtaining large quantities of insulin-producing cells suitable for transplantation into patients suffering from type 1 diabetes. It appeared that undifferentiated hIPCs are "committed" to a pancreatic endocrine phenotype through multiple cell divisions, suggesting that epigenetic modifications at the insulin locus could be responsible. We determined patterns of histone modifications over the insulin gene in human islets and hIPCs and compared them with HeLa and human bone marrow-derived mesenchymal stem cells (hBM-MSCs), neither of which expresses insulin. The insulin gene in islets displays high levels of histone modifications (H4 hyperacetylation and dimethylation of H3 lysine 4) typical of active genes. These are not present in HeLa and hBM-MSCs, which instead have elevated levels of H3 lysine 9 dimethylation, a mark of inactive genes. hIPCs, in contrast, show significant levels of active chromatin modifications, as much as half those seen in islets, and show no measurable H3 K9 methylation. Cells expanded from a minor population of mesenchymal stromal cells found in islets exhibit the same histone modifications as established hIPCs. We conclude that hIPCs, which do not express the insulin gene, nonetheless uniquely exhibit epigenetic marks that could poise them for activation of insulin expression. This epigenetic signature may be a general mechanism whereby tissue-derived precursor cells are committed to a distinct specification. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Mutskov, Vesco AU - Raaka, Bruce M AU - Felsenfeld, Gary AU - Gershengorn, Marvin C AD - Laboratory of Molecular Biology and Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3223 EP - 3233 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Epithelial cells KW - Histones KW - Chromatin KW - stromal cells KW - Pancreas KW - Bone marrow KW - Lysine KW - Transcription KW - Islets of Langerhans KW - Insulin KW - Pancreas transplantation KW - Diabetes mellitus KW - Cell division KW - Stem cells KW - epigenetics KW - DNA methylation KW - Mesenchyme KW - Methylation KW - W 30920:Tissue Engineering KW - G 07730:Development & Cell Cycle KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Human+Insulin+Gene+Displays+Transcriptionally+Active+Epigenetic+Marks+in+Islet-Derived+Mesenchymal+Precursor+Cells+in+the+Absence+of+Insulin+Expression&rft.au=Mutskov%2C+Vesco%3BRaaka%2C+Bruce+M%3BFelsenfeld%2C+Gary%3BGershengorn%2C+Marvin+C&rft.aulast=Mutskov&rft.aufirst=Vesco&rft.date=2007-12-01&rft.volume=25&rft.issue=12&rft.spage=3223&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Histones; stromal cells; Chromatin; Pancreas; Bone marrow; Transcription; Lysine; Islets of Langerhans; Insulin; Pancreas transplantation; Diabetes mellitus; Stem cells; Cell division; epigenetics; DNA methylation; Mesenchyme; Methylation ER - TY - JOUR T1 - Genome Sequence Analysis of the Emerging Human Pathogenic Acetic Acid Bacterium Granulibacter bethesdensis AN - 19900078; 7741959 AB - Chronic granulomatous disease (CGD) is an inherited immune deficiency characterized by increased susceptibility to infection with Staphylococcus, certain gram-negative bacteria, and fungi. Granulibacter bethesdensis, a newly described genus and species within the family Acetobacteraceae, was recently isolated from four CGD patients residing in geographically distinct locales who presented with fever and lymphadenitis. We sequenced the genome of the reference strain of Granulibacter bethesdensis, which was isolated from lymph nodes of the original patient. The genome contains 2,708,355 base pairs in a single circular chromosome, in which 2,437 putative open reading frames (ORFs) were identified, 1,470 of which share sequence similarity with ORFs in the nonpathogenic but related Gluconobacter oxydans genome. Included in the 967 ORFs that are unique to G. bethesdensis are ORFs potentially important for virulence, adherence, DNA uptake, and methanol utilization. GC% values and best BLAST analysis suggested that some of these unique ORFs were recently acquired. Comparison of G. bethesdensis to other known CGD pathogens demonstrated conservation of some putative virulence factors, suggesting possible common mechanisms involved in pathogenesis in CGD. Genotyping of the four patient isolates by use of a custom microarray demonstrated genome-wide variations in regions encoding DNA uptake systems and transcriptional regulators and in hypothetical ORFs. G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms. JF - Journal of Bacteriology AU - Greenberg, David E AU - Porcella, Stephen F AU - Zelazny, Adrian M AU - Virtaneva, Kimmo AU - Sturdevant, Dan E AU - Kupko, John JIII AU - Barbian, Kent D AU - Babar, Amenah AU - Dorward, David W AU - Holland, Steven M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840. Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8727 EP - 8736 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - virulence factors KW - Genotyping KW - Nucleotide sequence KW - Fungi KW - Staphylococcus KW - Methanol KW - Transcription KW - Gluconobacter oxydans KW - Pathogens KW - DNA microarrays KW - Acetic acid KW - Lymph nodes KW - Fever KW - Guanylate cyclase KW - Lymphadenitis KW - Gram-negative bacteria KW - Chronic infection KW - DNA KW - Conservation KW - Chronic granulomatous disease KW - Open reading frames KW - J 02400:Human Diseases KW - N 14810:Methods KW - G 07770:Bacteria KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genome+Sequence+Analysis+of+the+Emerging+Human+Pathogenic+Acetic+Acid+Bacterium+Granulibacter+bethesdensis&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BZelazny%2C+Adrian+M%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Dan+E%3BKupko%2C+John+JIII%3BBarbian%2C+Kent+D%3BBabar%2C+Amenah%3BDorward%2C+David+W%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; virulence factors; Fungi; Nucleotide sequence; Genotyping; Methanol; Transcription; Pathogens; Acetic acid; DNA microarrays; Lymph nodes; Fever; Guanylate cyclase; Lymphadenitis; Gram-negative bacteria; Chronic infection; DNA; Conservation; Chronic granulomatous disease; Open reading frames; Staphylococcus; Gluconobacter oxydans ER - TY - JOUR T1 - Transgenic Expression of Bcl-x sub(L) or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae AN - 19894073; 7743252 AB - IgG antipolysaccharide (PS) and antiprotein responses to Streptococcus pneumoniae (Pn) are both CD4 super(+) T cell dependent. However, the primary IgG anti-PS response terminates more quickly, uses a shorter period of T cell help, fails to generate memory, and is more dependent on membrane Ig (mIg) signaling. We thus determined whether this limited anti-PS response to Pn reflected a greater propensity of PS-specific B cells to undergo apoptosis. We used mice that constitutively expressed the antiapoptotic protein Bcl-x sub(L) or Bcl-2 as a B cell-specific transgene. Both transgenic (Tg) mice exhibited increased absolute numbers of splenic B-1 and peritoneal B-1b and B-2 cells, subsets implicated in anti-PS responses, but not in marginal zone B (MZB) cells. Both Tg mouse strains elicited, in an apparently Fas-independent manner, a more prolonged and higher peak primary IgM and IgG anti-PS, but not antiprotein, response to Pn, but without PS-specific memory. A similar effect was not observed using purified PS or pneumococcal conjugate vaccine. In vitro, both splenic MZB and follicular Tg B cells synthesized DNA at markedly higher levels than their wild-type counterparts, following mIg cross-linking. This was associated with increased clonal expansion and decreased apoptosis. Using Lsc super(-/-) mice, the Pn-induced IgG response specific for the capsular PS was found to be almost entirely dependent on MZB cells. Collectively, these data suggest that apoptosis may limit mIg-dependent clonal expansion of PS-specific B cells during a primary immune response to an intact bacterium, as well as decrease the pool of PS-responding B cell subsets. JF - Journal of Immunology AU - Chattopadhyay, Gouri AU - Khan, Abdul Q AU - Sen, Goutam AU - Colino, Jesus AU - duBois, Wendy AU - Rubtsov, Anatoly AU - Torres, Raul M AU - Potter, Michael AU - Snapper, Clifford M AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Center for Vaccine Development, University of Maryland, Baltimore, MD 21201. Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892. University of Colorado Health Sciences Center, Denver, CO 80207. Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80207 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7523 EP - 7534 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 11 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Data processing KW - Lymphocytes B KW - Peritoneum KW - Memory cells KW - Spleen KW - Transgenic mice KW - Bcl-x protein KW - Streptococcus pneumoniae KW - CD4 antigen KW - Lymphocytes T KW - Immunoglobulin G KW - DNA KW - Vaccines KW - Bcl-2 protein KW - Immunoglobulin M KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19894073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Transgenic+Expression+of+Bcl-x+sub%28L%29+or+Bcl-2+by+Murine+B+Cells+Enhances+the+In+Vivo+Antipolysaccharide%2C+but+Not+Antiprotein%2C+Response+to+Intact+Streptococcus+pneumoniae&rft.au=Chattopadhyay%2C+Gouri%3BKhan%2C+Abdul+Q%3BSen%2C+Goutam%3BColino%2C+Jesus%3BduBois%2C+Wendy%3BRubtsov%2C+Anatoly%3BTorres%2C+Raul+M%3BPotter%2C+Michael%3BSnapper%2C+Clifford+M&rft.aulast=Chattopadhyay&rft.aufirst=Gouri&rft.date=2007-12-01&rft.volume=179&rft.issue=11&rft.spage=7523&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Lymphocytes B; Peritoneum; Memory cells; Spleen; Transgenic mice; Bcl-x protein; CD4 antigen; DNA; Immunoglobulin G; Lymphocytes T; Bcl-2 protein; Vaccines; Immunoglobulin M; Signal transduction; Streptococcus pneumoniae ER - TY - JOUR T1 - The High-Precision Solution Structure of Yersinia Modulating Protein YmoA Provides Insight into Interaction with H-NS AN - 19891502; 8019312 AB - The high-resolution solution structure of Yersinia modulating protein YmoA is presented. The protein is all helical with the first three of four helices forming the central core. Structures calculated with only NOE and dihedral restraints exhibit a backbone root-mean-square deviation (rmsd) of 0.77 Aa. Upon refinement against H super(alpha)-C super(alpha), H super(N)-N, and C super(alpha)-C' J-modulated residual dipolar couplings, the backbone rmsd improves to 0.22 Aa. YmoA has a high amino acid sequence identity to and a similar overall fold to Escherichia coli hemolysin expression modulating protein Hha; however, structural differences do occur. YmoA is also found to be structurally similar to the histone-like nucleoid structuring protein H- NS, indicating that YmoA may intercalate into higher-order H-NS suprastructuring by substituting for an H-NS dimer. JF - Biochemistry (Washington) AU - McFeeters, Robert L AU - Altieri, Ama S AU - Cherry, Scott AU - Tropea, Joseph E AU - Waugh, David S AU - Byrd, RAndrew AD - Structural Biophysics Laboratory and Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 13975 EP - 13982 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 46 IS - 49 SN - 0006-2960, 0006-2960 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Protein folding KW - Escherichia coli KW - Nucleoids KW - Yersinia KW - Hemolysins KW - Amino acid sequence KW - N 14820:DNA Metabolism & Structure KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=The+High-Precision+Solution+Structure+of+Yersinia+Modulating+Protein+YmoA+Provides+Insight+into+Interaction+with+H-NS&rft.au=McFeeters%2C+Robert+L%3BAltieri%2C+Ama+S%3BCherry%2C+Scott%3BTropea%2C+Joseph+E%3BWaugh%2C+David+S%3BByrd%2C+RAndrew&rft.aulast=McFeeters&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=46&rft.issue=49&rft.spage=13975&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701210jPII%3AS0006-2960%2870%2901210-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Protein folding; Nucleoids; Hemolysins; Amino acid sequence; Escherichia coli; Yersinia DO - http://dx.doi.org/10.1021/bi701210jPII:S0006-2960(70)01210-2 ER - TY - JOUR T1 - Atomic-resolution crystal structure of the antiviral lectin scytovirin AN - 19886321; 7745951 AB - The crystal structures of the natural and recombinant antiviral lectin scytovirin (SVN) were solved by single-wavelength anomalous scattering and refined with data extending to 1.3 Aa and 1.0 Aa resolution, respectively. A molecule of SVN consists of a single chain 95 amino acids long, with an almost perfect sequence repeat that creates two very similar domains (RMS deviation 0.25 Aa for 40 pairs of C alpha atoms). The crystal structure differs significantly from a previously published NMR structure of the same protein, with the RMS deviations calculated separately for the N- and C-terminal domains of 5.3 Aa and 3.7 Aa, respectively, and a very different relationship between the two domains. In addition, the disulfide bonding pattern of the crystal structures differs from that described in the previously published mass spectrometry and NMR studies. JF - Protein Science AU - Moulaei, Tinoush AU - Botos, Istvan AU - Ziolkowska, Natasza E AU - Bokesch, Heidi R AU - Krumpe, Lauren R AU - McKee, Tawnya C AU - O'Keefe, Barry R AU - Dauter, Zbigniew AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. SAIC-Frederick Inc., National Cancer Institute, Frederick, Maryland 21702-1201, USA. Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne National Laboratory, Argonne, Illinois 60439, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2756 EP - 2760 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 12 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Data processing KW - Crystal structure KW - N.M.R. KW - Lectins KW - Mass spectroscopy KW - Amino acid sequence KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19886321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Atomic-resolution+crystal+structure+of+the+antiviral+lectin+scytovirin&rft.au=Moulaei%2C+Tinoush%3BBotos%2C+Istvan%3BZiolkowska%2C+Natasza+E%3BBokesch%2C+Heidi+R%3BKrumpe%2C+Lauren+R%3BMcKee%2C+Tawnya+C%3BO%27Keefe%2C+Barry+R%3BDauter%2C+Zbigniew%3BWlodawer%2C+Alexander&rft.aulast=Moulaei&rft.aufirst=Tinoush&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2756&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Crystal structure; Lectins; N.M.R.; Mass spectroscopy; Amino acid sequence ER - TY - JOUR T1 - Saccharomyces cerevisiae MutL alpha Is a Mismatch Repair Endonuclease AN - 19790160; 7935124 AB - MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutL alpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X) sub(2)E(X) sub(4)E motif (Kadyrov, F. A., Dzantiev, L., Constantin, N., and Modrich, P. (2006) Cell 126, 297-308). This sequence element is conserved in many MutL homologs, including the PMS1 subunit of Saccharomyces cerevisiae MutL alpha , but is absent in MutL proteins from bacteria like Escherichia coli that rely on d(GATC) methylation for strand directionality. We show that yeast MutL alpha is a strand-directed endonuclease that incises DNA in a reaction that depends on a mismatch, yMutS alpha , yRFC, yPCNA, ATP, and a pre-existing strand break, whereas E. coli MutL is not. Amino acid substitution within the PMS1 DQHA(X) sub(2)E(X) sub(4)E motif abolishes yMutL alpha endonuclease activity in vitro and confers strong genetic instability in vivo, but does not affect yMutL alpha ATPase activity or the ability of the protein to support assembly of the yMutL alpha .yMutS alpha .heteroduplex ternary complex. The loaded form of yPCNA may play an important effector role in directing yMutL alpha incision to the discontinuous strand of a nicked heteroduplex. JF - Journal of Biological Chemistry AU - Kadyrov, Farid A AU - Holmes, Shannon F AU - Arana, Mercedes E AU - Lukianova, Olga A AU - O'Donnell, Mike AU - Kunkel, Thomas A AU - Modrich, Paul AD - Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, the Laboratory of Structural Biology and Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, and the Laboratory of DNA Replication and Howard Hughes Medical Institute, Rockefeller University, New York 10021-6399 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37181 EP - 37190 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 51 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - MutL protein KW - mismatch repair KW - Adenosinetriphosphatase KW - Amino acid substitution KW - Escherichia coli KW - DNA KW - Conserved sequence KW - ATP KW - Endonuclease KW - Methylation KW - Saccharomyces cerevisiae KW - J 02410:Animal Diseases KW - K 03330:Biochemistry KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Saccharomyces+cerevisiae+MutL+alpha+Is+a+Mismatch+Repair+Endonuclease&rft.au=Kadyrov%2C+Farid+A%3BHolmes%2C+Shannon+F%3BArana%2C+Mercedes+E%3BLukianova%2C+Olga+A%3BO%27Donnell%2C+Mike%3BKunkel%2C+Thomas+A%3BModrich%2C+Paul&rft.aulast=Kadyrov&rft.aufirst=Farid&rft.date=2007-12-01&rft.volume=282&rft.issue=51&rft.spage=37181&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - MutL protein; Amino acid substitution; Adenosinetriphosphatase; mismatch repair; DNA; ATP; Conserved sequence; Endonuclease; Methylation; Escherichia coli; Saccharomyces cerevisiae ER - TY - JOUR T1 - MyoD Acetylation Influences Temporal Patterns of Skeletal Muscle Gene Expression AN - 19710399; 7935175 AB - MyoD is sufficient to initiate the skeletal muscle gene expression program. Transcription of certain MyoD target genes occurs in the early phases, whereas that of others is induced only at later stages, although MyoD is present throughout the differentiation process. MyoD acetylation regulates transcriptional competency, yet whether this post-translational modification is equally relevant for activation of all the MyoD targets is unknown. Moreover, the molecular mechanisms through which acetylation ensures that MyoD achieves its optimal activity remain unexplored. To address these two outstanding issues, we have coupled genome-wide expression profiling and chromatin immunoprecipitation in a model system in which MyoD or its nonacetylatable version was inducibly activated in mouse embryonic fibroblasts derived from MyoD super(-/-)/Myf5 super(-/-) mice. Our results reveal that MyoD acetylation influences transcription of selected genes expressed at defined stages of the muscle program by regulating chromatin access of MyoD, histone acetylation, and RNA polymerase II recruitment. JF - Journal of Biological Chemistry AU - Di Padova, Monica AU - Caretti, Giuseppina AU - Zhao, Po AU - Hoffman, Eric P AU - Sartorelli, Vittorio AD - Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, National Institutes of Health, Bethesda, Maryland 20829 and the Research Center for Genetic Medicine and Children's National Medical Center, Washington, D. C. 20010 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37650 EP - 37659 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 52 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Molecular modelling KW - Histones KW - Chromatin KW - Recruitment KW - Immunoprecipitation KW - Transcription KW - MyoD protein KW - Gene expression KW - Acetylation KW - Differentiation KW - DNA-directed RNA polymerase KW - Post-translation KW - Embryo fibroblasts KW - Skeletal muscle KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=MyoD+Acetylation+Influences+Temporal+Patterns+of+Skeletal+Muscle+Gene+Expression&rft.au=Di+Padova%2C+Monica%3BCaretti%2C+Giuseppina%3BZhao%2C+Po%3BHoffman%2C+Eric+P%3BSartorelli%2C+Vittorio&rft.aulast=Di+Padova&rft.aufirst=Monica&rft.date=2007-12-01&rft.volume=282&rft.issue=52&rft.spage=37650&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Histones; Chromatin; Recruitment; Immunoprecipitation; Transcription; MyoD protein; Gene expression; Differentiation; Acetylation; DNA-directed RNA polymerase; Post-translation; Embryo fibroblasts; Skeletal muscle ER - TY - JOUR T1 - Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters AN - 19705018; 7936724 AB - Camptothecin (CPT) analogues are powerful anticancer agents but are chemically unstable due to their alpha -hydroxylactone six-membered E-ring structure, which is essential for trapping topoisomerase I (Top1)-DNA cleavage complexes. To stabilize the E-ring, CPT keto analogues with a five-membered E-ring lacking the oxygen of the lactone ring (S38809 and S39625) have been synthesized. S39625 has been selected for advanced preclinical development based on its promising activity in tumor models. Here, we show that both keto analogues are active against purified Top1 and selective against Top1 in yeast and human cancer cells. The keto analogues show improved cytotoxicity toward colon, breast, and prostate cancer cells and leukemia cells compared with CPT. The drug-induced Top1-DNA cleavage complexes induced by the keto analogues show remarkable persistence both with purified Top1 and in cells following 1-h drug treatments. Moreover, we find that S39625 is not a substrate for either the ABCB1 (multidrug resistance-1/P-glycoprotein) or ABCG2 (mitoxantrone resistance/breast cancer resistance protein) drug efflux transporters, which sets S39625 apart from the clinically used CPT analogues topotecan or SN-38 (active metabolite of irinotecan). Finally, we show that nanomolar concentrations of S38809 or S39625 induce intense and persistent histone gamma -H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma -H2AX could be used as a biomarker for the upcoming clinical trials of S39625. [Mol Cancer Ther 2007; 6(12):3229-38] JF - Molecular Cancer Therapeutics AU - Takagi, Kazutaka AU - Dexheimer, Thomas S AU - Redon, Christophe AU - Sordet, Olivier AU - Agama, Keli AU - Lavielle, Gilbert AU - Pierre, Alain AU - Bates, Susan E AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland and Institut de Recherches Servier, Croissy sur Seine, France Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3229 EP - 3238 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Histones KW - Drug resistance KW - Irinotecan KW - Metabolites KW - lactones KW - Clinical trials KW - Leukemia KW - P-Glycoprotein KW - Tumor cell lines KW - Colon KW - Protein transport KW - DNA topoisomerase KW - Drug development KW - Tumors KW - biomarkers KW - Trapping KW - Antitumor agents KW - Camptothecin KW - Oxygen KW - Cytotoxicity KW - Prostate cancer KW - Breast cancer KW - Topotecan KW - mitoxantrone KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19705018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Novel+E-ring+camptothecin+keto+analogues+%28S38809+and+S39625%29+are+stable%2C+potent%2C+and+selective+topoisomerase+I+inhibitors+without+being+substrates+of+drug+efflux+transporters&rft.au=Takagi%2C+Kazutaka%3BDexheimer%2C+Thomas+S%3BRedon%2C+Christophe%3BSordet%2C+Olivier%3BAgama%2C+Keli%3BLavielle%2C+Gilbert%3BPierre%2C+Alain%3BBates%2C+Susan+E%3BPommier%2C+Yves&rft.aulast=Takagi&rft.aufirst=Kazutaka&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3229&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Histones; Drug resistance; Irinotecan; DNA topoisomerase; Drug development; Metabolites; lactones; Tumors; Antitumor agents; Clinical trials; Trapping; biomarkers; Camptothecin; Leukemia; Oxygen; Cytotoxicity; Tumor cell lines; P-Glycoprotein; Prostate cancer; Colon; Breast cancer; Topotecan; mitoxantrone ER - TY - JOUR T1 - Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient? AN - 19683940; 7933822 AB - Since the discovery of conventional chemotherapy and the development of new target-based agents, the importance of cytostasis in anticancer activity has been debated. This review examines the relative importance of both cytostasis and cytotoxicity based on both preclinical data and clinical reports. Several limitations of our basic and clinical methods to evaluate cytostasis and cytotoxicity will be highlighted. Molecular mechanisms of cytostasis will be analyzed, including interference with the cell cycle as well as putative links with necrosis and autophagy. Finally, we will cite evidence that most older and newer compounds are both cytostatic and cytotoxic. The relative role of cytostasis and cytotoxicity on future drug screening and clinical development will be explored. JF - Clinical Cancer Research AU - Rixe, Olivier AU - Fojo, Tito AD - Authors' Affiliations: Medical Oncology Department of the Salpetriere Hospital, Pierre and Marie Curie University, Paris, France and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 7280 EP - 7287 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 24 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Data processing KW - Chemotherapy KW - Cell cycle KW - Cytostasis KW - Drug screening KW - Cytotoxicity KW - Cell death KW - Necrosis KW - Reviews KW - Phagocytosis KW - Antitumor activity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19683940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Is+Cell+Death+a+Critical+End+Point+for+Anticancer+Therapies+or+Is+Cytostasis+Sufficient%3F&rft.au=Rixe%2C+Olivier%3BFojo%2C+Tito&rft.aulast=Rixe&rft.aufirst=Olivier&rft.date=2007-12-01&rft.volume=13&rft.issue=24&rft.spage=7280&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Necrosis; Cell death; Cytotoxicity; Data processing; Chemotherapy; Reviews; Cell cycle; Cytostasis; Drug screening; Phagocytosis; Antitumor activity ER - TY - JOUR T1 - Evidence of a conjugal erythromycin resistance element in the Lyme disease spirochete Borrelia burgdorferi AN - 19611389; 8580794 AB - We report the identification of isolates of Borrelia burgdorferi strain B31 that exhibit an unusual macrolide-lincosamide (ML) or macrolide- lincosamide-streptogramin A (MLS sub(A)) antibiotic resistance pattern. Low- passage isolates were resistant to high levels (>100 mu g/mL) of erythromycin, spiramycin and the lincosamides but were sensitive to dalfopristin, an analogue of streptogramin B. Interestingly, the high-passage erythromycin- resistant strain B31 was resistant to quinupristin, an analogue of streptogramin A (25 mu g/mL). Biochemical analysis revealed that resistance was not due to antibiotic inactivation or energy-dependent efflux but was instead due to modification of ribosomes in these isolates. Interestingly, we were able to demonstrate high-frequency transfer of the resistance phenotype via conjugation from B. burgdorferi to Bacillus subtilis (10 super(-2)- 10 super(-4)) or Enterococcus faecalis (10 super(-5)). An intergeneric conjugal system in B. burgdorferi suggests that horizontal gene transfer may play a role in its evolution and is a potential tool for developing new genetic systems to study the pathogenesis of Lyme disease. JF - International Journal of Antimicrobial Agents AU - Jackson, Charlene R AU - Boylan, Julie A AU - Frye, Jonathan G AU - Gherardini, Frank C AD - Antimicrobial Resistance Research Unit, ARS, SAA, USDA, Russell Research Center, Athens, GA 30602, USA, fgherardini@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 496 EP - 504 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 30 IS - 6 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Borrelia burgdorferi KW - Erythromycin KW - Antimicrobial resistance KW - Conjugation KW - Dalfopristin KW - Bacillus subtilis KW - Streptogramins KW - Enterococcus faecalis KW - Biochemical analysis KW - Ribosomes KW - Antibiotics KW - Spiramycin KW - quinupristin KW - Spirochetes KW - Gene transfer KW - streptogramin B KW - lincosamides KW - Antibiotic resistance KW - Evolution KW - Lyme disease KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Evidence+of+a+conjugal+erythromycin+resistance+element+in+the+Lyme+disease+spirochete+Borrelia+burgdorferi&rft.au=Jackson%2C+Charlene+R%3BBoylan%2C+Julie+A%3BFrye%2C+Jonathan+G%3BGherardini%2C+Frank+C&rft.aulast=Jackson&rft.aufirst=Charlene&rft.date=2007-12-01&rft.volume=30&rft.issue=6&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2007.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dalfopristin; Streptogramins; Biochemical analysis; Spiramycin; Antibiotics; Ribosomes; quinupristin; Erythromycin; Spirochetes; Gene transfer; streptogramin B; Evolution; Antibiotic resistance; lincosamides; Lyme disease; Bacillus subtilis; Borrelia burgdorferi; Enterococcus faecalis DO - http://dx.doi.org/10.1016/j.ijantimicag.2007.07.013 ER - TY - JOUR T1 - The antimicrobial peptide-sensing system aps of Staphylococcus aureus AN - 19527252; 7998761 AB - Staphylococcus aureus is a leading cause of hospital-associated and, more recently, community-associated infections caused by highly virulent methicillin-resistant strains (CA-MRSA). S. aureus survival in the human host is largely defined by the ability to evade attacks by antimicrobial peptides (AMPs) and other mechanisms of innate host defence. Here we show that AMPs induce resistance mechanisms in CA-MRSA via the aps AMP sensor-regulator system, including (i) the d-alanylation of teichoic acids, (ii) the incorporation of lysyl-phosphatidylglycerol in the bacterial membrane and a concomitant increase in lysine biosynthesis, and (iii) putative AMP transport systems such as the vraFG transporter, for which we demonstrate a function in AMP resistance. In contrast to the aps system of S. epidermidis, induction of the aps response in S. aureus was AMP-selective due to structural differences in the AMP binding loop of the ApsS sensor protein. Finally, using a murine infection model, we demonstrate the importance of the aps regulatory system in S. aureus infection. This study shows that while significant interspecies differences exist in the AMP-aps interaction, the AMP sensor system aps is functional and efficient in promoting resistance to a variety of AMPs in a clinically relevant strain of the important human pathogen S. aureus. JF - Molecular Microbiology AU - Li, Min AU - Cha, David J AU - Lai, Yuping AU - Villaruz, Amer E AU - Sturdevant, Daniel E AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis and, motto@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1136 EP - 1147 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 66 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Teichoic acids KW - Animal models KW - Lysine KW - Survival KW - Pathogens KW - Staphylococcus aureus KW - Infection KW - Antimicrobial peptides KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19527252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=The+antimicrobial+peptide-sensing+system+aps+of+Staphylococcus+aureus&rft.au=Li%2C+Min%3BCha%2C+David+J%3BLai%2C+Yuping%3BVillaruz%2C+Amer+E%3BSturdevant%2C+Daniel+E%3BOtto%2C+Michael&rft.aulast=Li&rft.aufirst=Min&rft.date=2007-12-01&rft.volume=66&rft.issue=5&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2007.05986.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Teichoic acids; Drug resistance; Animal models; Survival; Lysine; Pathogens; Infection; Antimicrobial peptides; Staphylococcus aureus DO - http://dx.doi.org/10.1111/j.1365-2958.2007.05986.x ER - TY - JOUR T1 - Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord AN - 19471296; 8235889 AB - During development, the organizer provides instructive signals to surrounding cells as well as contributing cells to axial structures. To dissect organizer function at different developmental stages, conditional approaches such as the Cre/loxP system for conditional mutagenesis are particularly useful. Here we describe two new Cre transgenic mouse lines, Foxa2 NFP-Cre and Nodal PNC-Cre, with activity in two organizer domains, the posterior notochord (PNC) and notochord. These lines were made using defined regulatory elements from the Foxa2 and Nodal genes that direct Cre expression in overlapping domains of the PNC and notochord. Our detailed analysis of the timing and location of Foxa2 NFP-Cre and Nodal PNC-Cre activity indicates that these lines are appropriate for conditional mutagenesis of genes expressed from early somite stages onward. genesis 45:729-736, 2007. Published 2007 Wiley-Liss, Inc. JF - Genesis AU - Kumar, Amit AU - Yamaguchi, Taihei AU - Sharma, Prashant AU - Kuehn, Michael R AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland, mkuehn@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 729 EP - 736 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 45 IS - 12 SN - 1526-954X, 1526-954X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Regulatory sequences KW - somites KW - Cre recombinase KW - Notochord KW - Developmental stages KW - Transgenic mice KW - Mutagenesis KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19471296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genesis&rft.atitle=Transgenic+mouse+lines+expressing+Cre+recombinase+specifically+in+posterior+notochord+and+notochord&rft.au=Kumar%2C+Amit%3BYamaguchi%2C+Taihei%3BSharma%2C+Prashant%3BKuehn%2C+Michael+R&rft.aulast=Kumar&rft.aufirst=Amit&rft.date=2007-12-01&rft.volume=45&rft.issue=12&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Genesis&rft.issn=1526954X&rft_id=info:doi/10.1002%2Fdvg.20346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - somites; Regulatory sequences; Cre recombinase; Developmental stages; Notochord; Transgenic mice; Mutagenesis DO - http://dx.doi.org/10.1002/dvg.20346 ER - TY - JOUR T1 - Some bacteria degrade explosives, others prefer boiling methanol AN - 1753456201; 7981591 JF - Environmental Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2905 EP - 2910 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Boiling KW - Methanol KW - Explosives KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753456201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Some+bacteria+degrade+explosives%2C+others+prefer+boiling+methanol&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2007-12-01&rft.volume=9&rft.issue=12&rft.spage=2905&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2007.01480.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Boiling; Methanol; Explosives; Bacteria DO - http://dx.doi.org/10.1111/j.1462-2920.2007.01480.x ER - TY - JOUR T1 - Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153. AN - 68546656; 17897947 AB - Mouse cytomegalovirus (MCMV), a beta-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted major histocompatibility complex, class I (MHC-I) structure. Functions attributed to some family members include down-regulation of host MHC-I (m152) and NKG2D ligands (m145, m152, and m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical, and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require beta2m or peptide and is expressed at the surface of MCMV-infected cells. Its 2.4-A crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended N terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family. JF - The Journal of biological chemistry AU - Mans, Janet AU - Natarajan, Kannan AU - Balbo, Andrea AU - Schuck, Peter AU - Eikel, Daniel AU - Hess, Sonja AU - Robinson, Howard AU - Simic, Hrvoje AU - Jonjic, Stipan AU - Tiemessen, Caroline T AU - Margulies, David H AD - Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-1892, USA. Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 SP - 35247 EP - 35258 VL - 282 IS - 48 SN - 0021-9258, 0021-9258 KW - Glycoproteins KW - 0 KW - Histocompatibility Antigens Class I KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Green Fluorescent Proteins -- chemistry KW - Models, Molecular KW - Amino Acid Sequence KW - Mice KW - Fibroblasts -- metabolism KW - NIH 3T3 Cells KW - Molecular Sequence Data KW - Molecular Conformation KW - Sequence Homology, Amino Acid KW - Crystallography, X-Ray -- methods KW - Drosophila KW - Protein Conformation KW - Glycoproteins -- chemistry KW - Gene Expression Regulation KW - Histocompatibility Antigens Class I -- chemistry KW - Muromegalovirus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68546656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cellular+expression+and+crystal+structure+of+the+murine+cytomegalovirus+major+histocompatibility+complex+class+I-like+glycoprotein%2C+m153.&rft.au=Mans%2C+Janet%3BNatarajan%2C+Kannan%3BBalbo%2C+Andrea%3BSchuck%2C+Peter%3BEikel%2C+Daniel%3BHess%2C+Sonja%3BRobinson%2C+Howard%3BSimic%2C+Hrvoje%3BJonjic%2C+Stipan%3BTiemessen%2C+Caroline+T%3BMargulies%2C+David+H&rft.aulast=Mans&rft.aufirst=Janet&rft.date=2007-11-30&rft.volume=282&rft.issue=48&rft.spage=35247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-11-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2O5N; PDB N1 - SuppNotes - Cited By: Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:299-308 [2484163] Mol Cell. 2002 Apr;9(4):789-98 [11983170] Science. 1992 Aug 14;257(5072):919-27 [1323877] J Mol Biol. 1993 Jun 20;231(4):1049-67 [8515464] J Mol Biol. 1993 Dec 20;234(4):946-50 [8263940] Nature. 1994 Nov 24;372(6504):336-43 [7969491] Science. 1996 Aug 2;273(5275):595-603 [8662544] J Virol. 1996 Dec;70(12):8833-49 [8971012] Immunity. 1997 Jan;6(1):57-66 [9052837] Nature. 1997 Apr 3;386(6624):510-4 [9087412] Immunity. 1997 Aug;7(2):273-82 [9285411] J Virol. 1998 Jan;72(1):460-6 [9420246] J Mol Evol. 1998 Apr;46(4):389-400 [9541533] Science. 2002 May 17;296(5571):1323-6 [11950999] Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8826-31 [12060703] Rheumatology (Oxford). 2002 Aug;41(8):857-68 [12154202] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] J Infect Dis. 2003 Mar 15;187(6):988-99 [12660946] J Exp Med. 2003 May 19;197(10):1245-53 [12756263] Nucleic Acids Res. 2003 Jul 1;31(13):3497-500 [12824352] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13483-8 [14597723] J Exp Med. 2004 Oct 18;200(8):1075-81 [15477345] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7447-51 [3532114] Nature. 1987 Oct 8-14;329(6139):506-12 [3309677] Nature. 1988 Jan 21;331(6153):269-72 [2827039] J Mol Biol. 2006 Apr 21;358(1):157-71 [16500675] J Biol Chem. 2006 Apr 14;281(15):10439-47 [16455647] Virology. 2006 Sep 1;352(2):450-65 [16781754] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10128-33 [17537914] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Bioinformatics. 1999 Apr;15(4):305-8 [10320398] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Exp Med. 2005 Jan 17;201(2):211-20 [15642742] J Virol. 2005 Mar;79(5):2920-30 [15709011] Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):465-71 [15809496] J Immunol. 2005 Dec 1;175(11):7457-65 [16301653] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] Biophys J. 2000 Mar;78(3):1606-19 [10692345] Annu Rev Immunol. 2000;18:861-926 [10837078] J Virol. 2000 Aug;74(16):7656-65 [10906222] Trends Microbiol. 2000 Sep;8(9):410-8 [10989308] Rev Immunogenet. 1999;1(1):32-46 [11256571] Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1373-82 [11567148] Immunity. 2002 Jan;16(1):77-86 [11825567] Annu Rev Biochem. 1990;59:253-88 [2115762] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rosiglitazone increases small dense low-density lipoprotein concentration and decreases high-density lipoprotein particle size in HIV-infected patients. AN - 68520100; 18025896 AB - After 12 weeks of rosiglitazone treatment, significant increases in total and small dense low-density lipoprotein, and the total: high-density lipoprotein (HDL)-cholesterol ratio were found. The large HDL concentration and HDL particle size decreased significantly with rosiglitazone compared with placebo. These data indicate the production of a more atherogenic lipid profile with rosiglitazone, a consideration when selecting treatment for the growing population of HIV-infected patients with type 2 diabetes and dyslipidemia. JF - AIDS (London, England) AU - Hadigan, Colleen AU - Mazza, Sasha AU - Crum, Dana AU - Grinspoon, Steven AD - National Institute of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA. Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 SP - 2543 EP - 2546 VL - 21 IS - 18 KW - Hypoglycemic Agents KW - 0 KW - Lipoproteins, HDL KW - Lipoproteins, LDL KW - PPAR gamma KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Index Medicus KW - AIDS/HIV KW - Particle Size KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Insulin Resistance KW - Male KW - Female KW - PPAR gamma -- agonists KW - Lipoproteins, LDL -- blood KW - Hypoglycemic Agents -- therapeutic use KW - HIV-Associated Lipodystrophy Syndrome -- drug therapy KW - Lipoproteins, HDL -- blood KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - HIV-Associated Lipodystrophy Syndrome -- blood KW - Thiazolidinediones -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68520100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Rosiglitazone+increases+small+dense+low-density+lipoprotein+concentration+and+decreases+high-density+lipoprotein+particle+size+in+HIV-infected+patients.&rft.au=Hadigan%2C+Colleen%3BMazza%2C+Sasha%3BCrum%2C+Dana%3BGrinspoon%2C+Steven&rft.aulast=Hadigan&rft.aufirst=Colleen&rft.date=2007-11-30&rft.volume=21&rft.issue=18&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Classification Analysis of HIV RNase H Bioassay T2 - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AN - 39658266; 4741168 JF - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AU - Han, Lianyi AU - Wang, Yanli AU - Bryant, Steve Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 KW - Human immunodeficiency virus KW - Bioassays KW - Classification KW - Ribonuclease H KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39658266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.atitle=Classification+Analysis+of+HIV+RNase+H+Bioassay&rft.au=Han%2C+Lianyi%3BWang%2C+Yanli%3BBryant%2C+Steve&rft.aulast=Han&rft.aufirst=Lianyi&rft.date=2007-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/rocky07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Structure-based Sequence Alignment of Automatic Methods T2 - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AN - 39603428; 4741163 JF - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AU - Lee, Byungkook AU - Kim, Changhoon Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 KW - Nucleotide sequence KW - Automation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39603428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.atitle=Accuracy+of+Structure-based+Sequence+Alignment+of+Automatic+Methods&rft.au=Lee%2C+Byungkook%3BKim%2C+Changhoon&rft.aulast=Lee&rft.aufirst=Byungkook&rft.date=2007-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/rocky07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Palmitoylation of POTE family proteins for plasma membrane targeting. AN - 68364152; 17904529 AB - The POTE gene family is composed of 13 paralogs and likely evolved by duplications and remodeling of the human genome. One common property of POTE proteins is their localization on the inner aspect of the plasma membrane. To determine the structural elements required for membrane localization, we expressed mutants of different POTEs in 293T cells as EGFP fusion proteins. We also tested their palmitoylation by a biotin-switch assay. Our data indicate that the membrane localizations of different POTEs are mediated by similar 3-4 short cysteine rich repeats (CRRs) near the amino-terminuses and that palmitoylation on paired cysteine residues in each CRR motif is responsible for the localization. Multiple palmitoylation in the small CRRs can result in the strong association of whole POTEs with plasma membrane. JF - Biochemical and biophysical research communications AU - Das, Sudipto AU - Ise, Tomoko AU - Nagata, Satoshi AU - Maeda, Hiroshi AU - Bera, Tapan K AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4264, USA. Y1 - 2007/11/23/ PY - 2007 DA - 2007 Nov 23 SP - 751 EP - 756 VL - 363 IS - 3 SN - 0006-291X, 0006-291X KW - Membrane Proteins KW - 0 KW - Palmitates KW - Protein Isoforms KW - Recombinant Fusion Proteins KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - 2-bromopalmitate KW - 18263-25-7 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Microscopy, Confocal KW - Immunoblotting KW - Protein Structure, Secondary KW - Cysteine -- metabolism KW - Lipoylation -- drug effects KW - Protein Transport -- drug effects KW - Protein Isoforms -- metabolism KW - Cysteine -- genetics KW - Humans KW - Amino Acid Sequence KW - Palmitates -- pharmacology KW - Mutagenesis KW - Green Fluorescent Proteins -- genetics KW - Cysteine -- chemistry KW - Protein Transport -- genetics KW - Protein Isoforms -- chemistry KW - Amino Acid Motifs KW - Transfection KW - Protein Isoforms -- genetics KW - Mutation KW - Green Fluorescent Proteins -- metabolism KW - Cell Line KW - Recombinant Fusion Proteins -- metabolism KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Membrane Proteins -- genetics KW - Cell Membrane -- metabolism KW - Recombinant Fusion Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Palmitoylation+of+POTE+family+proteins+for+plasma+membrane+targeting.&rft.au=Das%2C+Sudipto%3BIse%2C+Tomoko%3BNagata%2C+Satoshi%3BMaeda%2C+Hiroshi%3BBera%2C+Tapan+K%3BPastan%2C+Ira&rft.aulast=Das&rft.aufirst=Sudipto&rft.date=2007-11-23&rft.volume=363&rft.issue=3&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2002 Feb 20;513(1):119-23 [11911890] J Biol Chem. 2007 Mar 30;282(13):10047-56 [17272284] Trends Cell Biol. 2003 Jan;13(1):32-42 [12480338] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16975-80 [12475935] Biotechniques. 2004 Feb;36(2):276-85 [14989092] Protein Sci. 2004 Jun;13(6):1435-48 [15152081] Annu Rev Biochem. 2004;73:559-87 [15189153] Gene. 2004 Aug 4;337:45-53 [15276201] Cancer Res. 2004 Oct 15;64(20):7455-63 [15492270] J Cell Biol. 1982 Apr;93(1):97-102 [7068762] Cell. 1985 Sep;42(2):497-505 [2992801] Trends Biochem Sci. 1995 May;20(5):181-7 [7610481] Curr Opin Cell Biol. 1997 Apr;9(2):148-54 [9069258] Biochim Biophys Acta. 1999 Aug 12;1451(1):1-16 [10446384] Science. 2005 Mar 18;307(5716):1746-52 [15705808] J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92 [15811950] Curr Opin Neurobiol. 2005 Oct;15(5):527-35 [16125924] Crit Care Med. 2005 Dec;33(12 Suppl):S407-9 [16340406] Cancer Res. 2006 Jan 1;66(1):52-6 [16397215] Gene. 2006 Feb 1;366(2):238-45 [16364570] Bioinformatics. 2006 Apr 1;22(7):894-6 [16434441] Cell. 2006 Jun 2;125(5):1003-13 [16751107] Methods. 2006 Oct;40(2):191-7 [17012032] BMC Bioinformatics. 2006;7:458 [17044919] Sci STKE. 2006 Oct 31;2006(359):re14 [17077383] Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17885-90 [17101985] Biol Res. 2002;35(2):139-50 [12415731] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Poxvirus DNA primase. AN - 68551375; 18000036 AB - Poxviruses are large enveloped viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. At least six virus-encoded proteins are required for synthesis and processing of the double-stranded DNA genome of vaccinia virus, the prototype member of the family. One of these proteins, D5, is an NTPase that contains an N-terminal archaeoeukaryotic primase domain and a C-terminal superfamily III helicase domain. Here we report that individual conserved aspartic acid residues in the predicted primase active site were required for in vivo complementation of infectious virus formation as well as genome and plasmid replication. Furthermore, purified recombinant D5 protein synthesized oligoribonucleotides in vitro. Incorporation of label from [alpha-(32)P]CTP or [alpha-(32)P]UTP into a RNase-sensitive and DNase-resistant product was demonstrated by using single-stranded circular bacteriophage DNA templates and depended on ATP or GTP and a divalent cation. Mutagenesis studies showed that the primase and NTPase activities of the recombinant D5 protein could be independently inactivated. Highly conserved orthologs of D5 are present in all poxviruses that have been sequenced, and more diverged orthologs are found in members of all other families of nucleocytoplasmic large DNA viruses. These viral primases may have roles in initiation of DNA replication or lagging-strand synthesis and represent potential therapeutic targets. JF - Proceedings of the National Academy of Sciences of the United States of America AU - De Silva, Frank S AU - Lewis, Whitney AU - Berglund, Peter AU - Koonin, Eugene V AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3210, USA. Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 18724 EP - 18729 VL - 104 IS - 47 KW - Amino Acids KW - 0 KW - Oligonucleotides KW - DNA Primase KW - EC 2.7.7.- KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - Index Medicus KW - Genome, Viral -- genetics KW - Plasmids -- genetics KW - HeLa Cells KW - Humans KW - Amino Acids -- genetics KW - Mutation -- genetics KW - Amino Acids -- metabolism KW - Acid Anhydride Hydrolases -- metabolism KW - Genetic Vectors -- genetics KW - Oligonucleotides -- metabolism KW - Catalysis KW - Binding Sites KW - DNA Primase -- genetics KW - Poxviridae -- enzymology KW - Poxviridae -- genetics KW - DNA Primase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68551375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Poxvirus+DNA+primase.&rft.au=De+Silva%2C+Frank+S%3BLewis%2C+Whitney%3BBerglund%2C+Peter%3BKoonin%2C+Eugene+V%3BMoss%2C+Bernard&rft.aulast=De+Silva&rft.aufirst=Frank&rft.date=2007-11-20&rft.volume=104&rft.issue=47&rft.spage=18724&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11178-92 [15249657] Virology. 2007 Apr 10;360(2):376-87 [17156813] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4879-84 [10781095] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8926-31 [10890916] Annu Rev Biochem. 2001;70:39-80 [11395402] J Virol. 2003 Jan;77(1):159-66 [12477821] Virology. 2002 Nov 25;303(2):232-9 [12490386] J Struct Biol. 2004 Apr-May;146(1-2):11-31 [15037234] Annu Rev Biochem. 2004;73:589-615 [15189154] J Cell Biol. 1976 Mar;68(3):557-66 [1030704] Virology. 1977 May 1;78(1):57-75 [860412] Virology. 1977 Oct 15;82(2):308-22 [919343] J Biol Chem. 1979 Aug 25;254(16):7812-9 [468791] Virology. 1980 Mar;101(2):520-4 [6244700] Virology. 1981 Jan 15;108(1):241-8 [7269237] Cell. 1981 Dec;27(2 Pt 1):391-401 [6277506] Nucleic Acids Res. 1982 Sep 25;10(18):5673-9 [6292846] Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:723-9 [6574869] Virology. 1984 Jan 30;132(2):436-44 [6322422] Proc Natl Acad Sci U S A. 1986 Feb;83(3):614-8 [3003742] Virology. 1987 Sep;160(1):110-9 [2820124] J Mol Biol. 1988 Feb 5;199(3):399-413 [3351934] FEBS Lett. 1990 Mar 12;262(1):145-8 [2156730] Virology. 1990 Nov;179(1):267-75 [2219723] Virology. 1991 Feb;180(2):625-32 [1989387] EMBO J. 1991 Dec;10(13):4343-50 [1756739] J Virol. 1992 May;66(5):2934-42 [1560532] J Virol. 1992 Aug;66(8):4710-9 [1629951] J Virol. 1992 Aug;66(8):4884-92 [1321275] EMBO J. 1992 Nov;11(11):4111-8 [1327758] Chromosoma. 1992;102(1 Suppl):S72-82 [1291243] Virology. 1994 Feb;198(2):504-13 [8291232] J Biol Chem. 1994 Dec 9;269(49):31190-7 [7983061] Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6773-7 [7624318] J Virol. 1995 Sep;69(9):5353-61 [7636979] EMBO J. 1997 Dec 15;16(24):7468-80 [9405375] J Biol Chem. 2004 Dec 10;279(50):52210-7 [15471883] Nucleic Acids Res. 2005;33(12):3875-96 [16027112] J Virol. 2005 Dec;79(24):15084-90 [16306579] Virol J. 2005;2:23 [15784143] J Biol Chem. 2006 Feb 10;281(6):3439-51 [16326701] Virus Res. 2006 Apr;117(1):156-84 [16494962] Mol Biol Cell. 2006 May;17(5):2451-64 [16495336] Bioinformatics. 2006 Dec 1;22(23):2846-50 [17021162] J Virol. 2007 Jan;81(2):844-59 [17093187] J Virol. 2004 Oct;78(19):10238-48 [15367589] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Depression, Inflammation, and Incident Cardiovascular Disease in Women With Suspected Coronary Ischemia AN - 1506196392; 18021871 AB - Depression, Inflammation, and Incident Cardiovascular Disease in Women With Suspected Coronary Ischemia: The National Heart, Lung, and Blood Institute-Sponsored WISE Study Viola Vaccarino, B. Delia Johnson, David S. Sheps, Steven E. Reis, Sheryl F. Kelsey, Vera Bittner, Thomas Rutledge, Leslee J. Shaw, George Sopko, C. Noel Bairey Merz It is unclear whether inflammation is a mechanism linking depression to cardiovascular disease (CVD). We examined whether the level of 2 inflammatory biomarkers, interleukin-6 and C-reactive protein, explained the relationship between depression and CVD in 559 women referred for coronary angiography for suspected coronary ischemia. Women with depression, defined as having both elevated depressive symptoms and a previous diagnosis of depression, showed robust elevations in inflammatory biomarkers at baseline and were also at higher risk of CVD over the follow-up. However, inflammation explained only a small portion of the association between depression and CVD. JF - Journal of the American College of Cardiology AU - Vaccarino, Viola AU - Johnson, B Delia AU - Sheps, David S AU - Reis, Steven E AU - Kelsey, Sheryl F AU - Bittner, Vera AU - Rutledge, Thomas AU - Shaw, Leslee J AU - Sopko, George AU - Bairey Merz, C Noel Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 2044 EP - 50 CY - New York PB - Elsevier Limited VL - 50 IS - 21 SN - 07351097 KW - Medical Sciences--Cardiovascular Diseases KW - Biological Markers KW - Interleukin-6 KW - C-Reactive Protein KW - Heart attacks KW - Mental depression KW - Womens health KW - Cardiovascular disease KW - Older people KW - Myocardial Ischemia -- blood KW - Cardiovascular Diseases -- blood KW - Humans KW - Coronary Angiography KW - Inflammation -- blood KW - Aged KW - Myocardial Ischemia -- complications KW - C-Reactive Protein -- analysis KW - Depressive Disorder -- blood KW - Interleukin-6 -- blood KW - Biological Markers -- blood KW - Coronary Artery Disease -- blood KW - Coronary Artery Disease -- radiography KW - Risk Factors KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Cardiovascular Diseases -- radiography KW - Female KW - Cardiovascular Diseases -- complications KW - Inflammation -- complications KW - Depressive Disorder -- complications KW - Coronary Artery Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1506196392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Depression%2C+Inflammation%2C+and+Incident+Cardiovascular+Disease+in+Women+With+Suspected+Coronary+Ischemia%3A+The+National+Heart%2C+Lung%2C+and+Blood+Institute-Sponsored+WISE+Study&rft.au=Vaccarino%2C+Viola%3BJohnson%2C+B+Delia%3BSheps%2C+David+S%3BReis%2C+Steven+E%3BKelsey%2C+Sheryl+F%3BBittner%2C+Vera%3BRutledge%2C+Thomas%3BShaw%2C+Leslee+J%3BSopko%2C+George%3BBairey+Merz%2C+C+Noel&rft.aulast=Vaccarino&rft.aufirst=Viola&rft.date=2007-11-20&rft.volume=50&rft.issue=21&rft.spage=2044&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2007.07.069 LA - English DB - ProQuest Central N1 - Copyright - Copyright Elsevier Limited Nov 20, 2007 N1 - Last updated - 2014-03-31 DO - http://dx.doi.org/10.1016/j.jacc.2007.07.069 ER - TY - JOUR T1 - Successful treatment of tremor in Wilson's disease by thalamotomy: A case report. AN - 85412732; pmid-17914724 AB - Little information is available on the surgical treatment of movement disorders in Wilson's disease. We report a successful outcome of left-sided stereotactic thalamotomy in a 30-year-old man with Wilson's disease, who had severe postural-kinetic tremor of both hands. The improvement was bilateral. Our case illustrates that stereotactic thalamotomy may be considered as an option in treating severe tremor in selected patients of Wilson's disease and merit further trials.(c) 2007 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pal, Pramod Kumar AU - Sinha, Sanjib AU - Pillai, Shibu AU - Taly, Arun B AU - Abraham, Rojin G AD - Department of Neurology National Institute of Mental Health and Neurosciences, Bangalore, India. palpramod@hotmail.com Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2287 EP - 2290 VL - 22 IS - 15 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Hepatolenticular Degeneration: complications KW - Hepatolenticular Degeneration: pathology KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - *Neurosurgical Procedures KW - *Thalamus: surgery KW - *Tremor: etiology KW - Tremor: pathology KW - *Tremor: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85412732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Successful+treatment+of+tremor+in+Wilson%27s+disease+by+thalamotomy%3A+A+case+report.&rft.au=Pal%2C+Pramod+Kumar%3BSinha%2C+Sanjib%3BPillai%2C+Shibu%3BTaly%2C+Arun+B%3BAbraham%2C+Rojin+G&rft.aulast=Pal&rft.aufirst=Pramod&rft.date=2007-11-15&rft.volume=22&rft.issue=15&rft.spage=2287&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. AN - 68514356; 17982122 AB - CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade. We have now treated 139 patients in two trials and have sufficient follow-up to examine factors associated with clinical response. A total of 139 patients with metastatic melanoma were treated: 54 patients received ipilimumab in conjunction with peptide vaccinations and 85 patients were treated with intra-patient dose escalation of ipilimumab and randomized to receive peptides in accordance with HLA-A*0201 status. Three patients achieved complete responses (CR; ongoing at 29+, 52+, and 53+ months); an additional 20 patients achieved partial responses (PR) for an overall objective response rate of 17%. The majority of patients (62%, 86 of 139) developed some form of IRAE, which was associated with a greater probability of objective antitumor response (P = 0.0004); all patients with CR had more severe IRAEs. Prior therapy with IFNalpha-2b was a negative prognostic factor, whereas prior high-dose interleukin-2 did not significantly affect the probability of response. There were no significant differences in the rate of clinical response or development of IRAEs between the two trials. The duration of tumor response was not affected by the use of high-dose steroids for abrogation of treatment-related toxicities (P = 0.23). There were no treatment-related deaths. In patients with metastatic melanoma, ipilimumab can induce durable objective clinical responses, which are related to the induction of IRAEs. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Downey, Stephanie G AU - Klapper, Jacob A AU - Smith, Franz O AU - Yang, James C AU - Sherry, Richard M AU - Royal, Richard E AU - Kammula, Udai S AU - Hughes, Marybeth S AU - Allen, Tamika E AU - Levy, Catherine L AU - Yellin, Michael AU - Nichol, Geoffrey AU - White, Donald E AU - Steinberg, Seth M AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 6681 EP - 6688 VL - 13 IS - 22 Pt 1 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Prognosis KW - Aged KW - Middle Aged KW - Male KW - Female KW - Skin Neoplasms -- drug therapy KW - Skin Neoplasms -- immunology KW - Melanoma -- secondary KW - Melanoma -- drug therapy KW - Skin Neoplasms -- pathology KW - Antigens, CD -- drug effects KW - Antibodies, Monoclonal -- pharmacology KW - Melanoma -- immunology KW - Antigens, Differentiation -- drug effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68514356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Prognostic+factors+related+to+clinical+response+in+patients+with+metastatic+melanoma+treated+by+CTL-associated+antigen-4+blockade.&rft.au=Downey%2C+Stephanie+G%3BKlapper%2C+Jacob+A%3BSmith%2C+Franz+O%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BRoyal%2C+Richard+E%3BKammula%2C+Udai+S%3BHughes%2C+Marybeth+S%3BAllen%2C+Tamika+E%3BLevy%2C+Catherine+L%3BYellin%2C+Michael%3BNichol%2C+Geoffrey%3BWhite%2C+Donald+E%3BSteinberg%2C+Seth+M%3BRosenberg%2C+Steven+A&rft.aulast=Downey&rft.aufirst=Stephanie&rft.date=2007-11-15&rft.volume=13&rft.issue=22+Pt+1&rft.spage=6681&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] J Immunother. 2007 Jan;30(1):130 [17198092] Annu Rev Immunol. 2001;19:565-94 [11244047] J Exp Med. 2001 Jun 4;193(11):1311-8 [11390438] Eur J Immunol. 2002 Feb;32(2):366-73 [11807776] Nat Rev Immunol. 2001 Dec;1(3):220-8 [11905831] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] Nat Rev Immunol. 2002 Jun;2(6):389-400 [12093005] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Immunol. 2004 Aug 15;173(4):2866-76 [15295006] J Exp Med. 1991 Mar 1;173(3):721-30 [1847722] J Exp Med. 1991 Mar 1;173(3):759-62 [1847724] J Exp Med. 1991 Sep 1;174(3):561-9 [1714933] J Immunol. 1993 Oct 1;151(7):3489-99 [8397258] Immunity. 1994 Aug;1(5):405-13 [7882171] Science. 1995 Nov 10;270(5238):985-8 [7481803] Science. 1996 Mar 22;271(5256):1734-6 [8596936] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] J Exp Med. 1996 Jun 1;183(6):2541-50 [8676075] Immunity. 1997 Dec;7(6):885-95 [9430233] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10067-71 [9707601] Ann Surg. 1998 Sep;228(3):307-19 [9742914] J Immunol. 1999 May 15;162(10):5813-20 [10229815] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] J Immunother. 2004 Nov-Dec;27(6):478-9 [15534492] J Clin Oncol. 2005 Feb 1;23(4):741-50 [15613700] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Immunother. 2005 Nov-Dec;28(6):593-8 [16224277] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] N Engl J Med. 2006 Feb 16;354(7):709-18 [16481638] J Clin Oncol. 2006 May 20;24(15):2283-9 [16710025] J Immunother. 2006 Jul-Aug;29(4):455-63 [16799341] Blood. 2006 Dec 1;108(12):3818-23 [16882704] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. AN - 68506505; 18006828 AB - The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Using a gene expression profiling approach, we recently identified a novel prognostic HCC subtype that resembles hepatic progenitor cells with the activation of stem cell markers and Wnt-beta-catenin signaling, based on EpCAM (epithelial cell adhesion molecule, a hepatic stem cell marker) expression. In this study, we investigated whether the activation of the Wnt-beta-catenin pathway regulates EpCAM expression. We found that nuclear accumulation of beta-catenin induced, whereas the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation reduced EpCAM gene expression in cultured normal human hepatocytes and HCC cell lines. We identified two Tcf binding elements in the EpCAM promoter that specifically bound to Tcf-4 in an electrophoretic mobility shift assay. EpCAM promoter luciferase activity was down-regulated by the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation. Furthermore, we found that EpCAM-positive HCC is much more sensitive to Tcf/beta-catenin binding inhibitors than EpCAM-negative HCC in vitro. Taken together, our data indicate that EpCAM is a Wnt-beta-catenin signaling target gene and may be used to facilitate HCC prognosis by enabling effective stratification of patients with predicted pharmacologic responses to Wnt-beta-catenin signaling antagonists. JF - Cancer research AU - Yamashita, Taro AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 10831 EP - 10839 VL - 67 IS - 22 KW - Antigens, Neoplasm KW - 0 KW - Cell Adhesion Molecules KW - Epithelial Cell Adhesion Molecule KW - Wnt Proteins KW - beta Catenin KW - Index Medicus KW - Promoter Regions, Genetic KW - Humans KW - Cell Line, Tumor KW - Cell Proliferation KW - Signal Transduction KW - Wnt Proteins -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Liver Neoplasms -- metabolism KW - Liver -- cytology KW - Carcinoma, Hepatocellular -- metabolism KW - Antigens, Neoplasm -- biosynthesis KW - beta Catenin -- metabolism KW - Stem Cells -- metabolism KW - Cell Adhesion Molecules -- physiology KW - Cell Adhesion Molecules -- biosynthesis KW - Hepatocytes -- metabolism KW - Antigens, Neoplasm -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68506505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Activation+of+hepatic+stem+cell+marker+EpCAM+by+Wnt-beta-catenin+signaling+in+hepatocellular+carcinoma.&rft.au=Yamashita%2C+Taro%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BWang%2C+Xin+Wei&rft.aulast=Yamashita&rft.aufirst=Taro&rft.date=2007-11-15&rft.volume=67&rft.issue=22&rft.spage=10831&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502). AN - 68487790; 17939651 AB - Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but caused rapid apoptosis. Unlike the parent compound, 7b is toxic to both p53 positive and negative cancer cells. It has potent in vivo activity against xenografts of human colon and pancreatic tumors in athymic mice. JF - Journal of medicinal chemistry AU - Hariprakasha, Humcha K AU - Kosakowska-Cholody, Teresa AU - Meyer, Colin AU - Cholody, Wieslaw M AU - Stinson, Sherman F AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Molecular Aspects of Drug Design Section, Structural Biophysics Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 5557 EP - 5560 VL - 50 IS - 23 SN - 0022-2623, 0022-2623 KW - Acridones KW - 0 KW - Antineoplastic Agents KW - Naphthalimides KW - RTA 502 KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Apoptosis KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Tissue Distribution KW - Tumor Suppressor Protein p53 -- metabolism KW - Structure-Activity Relationship KW - Neoplasm Transplantation KW - Rats KW - Transplantation, Heterologous KW - Naphthalimides -- chemistry KW - Antineoplastic Agents -- pharmacokinetics KW - Acridones -- chemical synthesis KW - Acridones -- chemistry KW - Antineoplastic Agents -- chemical synthesis KW - Acridones -- pharmacology KW - Acridones -- pharmacokinetics KW - Naphthalimides -- pharmacokinetics KW - Naphthalimides -- chemical synthesis KW - Antineoplastic Agents -- pharmacology KW - Naphthalimides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68487790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Optimization+of+naphthalimide-imidazoacridone+with+potent+antitumor+activity+leading+to+clinical+candidate+%28HKH40A%2C+RTA+502%29.&rft.au=Hariprakasha%2C+Humcha+K%3BKosakowska-Cholody%2C+Teresa%3BMeyer%2C+Colin%3BCholody%2C+Wieslaw+M%3BStinson%2C+Sherman+F%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Hariprakasha&rft.aufirst=Humcha&rft.date=2007-11-15&rft.volume=50&rft.issue=23&rft.spage=5557&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fear-potentiated startle to threat, and prepulse inhibition among young adult nonsmokers, abstinent smokers, and nonabstinent smokers. AN - 68478551; 17543892 AB - Evidence suggests that the transition from experimental to regular smoking is facilitated by the influence of tobacco on affective and attentional mechanisms. The objective of this study was to examine affective and attentional responses in young adult smokers using fear-potentiated startle and prepulse inhibition. Participants were 56 college nonsmokers, nonabstinent smokers, and overnight-abstinent smokers. The fear-potentiated startle test examined phasic responses to imminent threat cues and more sustained responses to unpredictable aversive events. Prepulse inhibition investigated responses to attended and ignored prepulse stimuli. Abstinent and nonabstinent smokers showed increased sustained potentiation of startle to contextual cues, compared to controls. Abstinent smokers showed increased fear-potentiated startle to threat cues, compared to nonsmokers. PPI did not discriminate between abstinent or nonabstinent smokers and controls. These findings suggest that negative affectivity or anxiety is associated with smoking, particularly during short withdrawal. Potentiated startle may provide a valuable tool in understanding the biologic mechanisms underlying nicotine withdrawal and inform cessation and prevention efforts. JF - Biological psychiatry AU - Grillon, Christian AU - Avenevoli, Shelli AU - Daurignac, Elsa AU - Merikangas, Kathleen R AD - Unit of Affective Psychophysiology, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892-2670, USA. christian.grillon@nih.gov Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 1155 EP - 1161 VL - 62 IS - 10 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Emotions -- physiology KW - Humans KW - Smoking Cessation KW - Adult KW - Electromyography KW - Habituation, Psychophysiologic KW - Adolescent KW - Acoustic Stimulation -- methods KW - Time Factors KW - Male KW - Female KW - Anxiety -- etiology KW - Smoking -- physiopathology KW - Tobacco Use Disorder -- physiopathology KW - Fear KW - Reflex, Startle -- physiology KW - Inhibition (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68478551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Fear-potentiated+startle+to+threat%2C+and+prepulse+inhibition+among+young+adult+nonsmokers%2C+abstinent+smokers%2C+and+nonabstinent+smokers.&rft.au=Grillon%2C+Christian%3BAvenevoli%2C+Shelli%3BDaurignac%2C+Elsa%3BMerikangas%2C+Kathleen+R&rft.aulast=Grillon&rft.aufirst=Christian&rft.date=2007-11-15&rft.volume=62&rft.issue=10&rft.spage=1155&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Psychiatry. 1997 Nov;154(11):1589-92 [9356569] J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):925-32 [9204670] Biol Psychiatry. 1998 Nov 15;44(10):990-7 [9821563] Biol Psychiatry. 1998 Dec 15;44(12):1239-47 [9861467] Pharmacol Biochem Behav. 1999 Feb;62(2):273-84 [9972694] Biol Psychiatry. 2005 Jan 1;57(1):56-66 [15607301] Nicotine Tob Res. 2006 Jun;8(3):379-92 [16801296] Psychophysiology. 2006 Jul;43(4):344-56 [16916430] Am Psychol. 1999 Oct;54(10):817-20 [10540594] Psychopharmacology (Berl). 2000 Jun;150(3):244-52 [10923751] Psychopharmacology (Berl). 2000 Jun;150(3):283-91 [10923756] Arch Gen Psychiatry. 2001 Sep;58(9):810-6 [11545662] Psychopharmacology (Berl). 2001 Jul;156(2-3):117-54 [11549216] Psychopharmacology (Berl). 2001 Jul;156(2-3):194-215 [11549223] Psychopharmacology (Berl). 2001 Jul;156(2-3):266-72 [11549228] Am J Psychiatry. 2002 Jul;159(7):1208-13 [12091201] Psychol Bull. 2003 Mar;129(2):270-304 [12696841] Psychopharmacology (Berl). 2003 May;167(3):235-41 [12677352] Clin Neurophysiol. 2003 Sep;114(9):1557-79 [12948786] Addict Behav. 2004 Jul;29(5):911-9 [15219335] Int J Methods Psychiatr Res. 2004;13(2):93-121 [15297906] Behav Neurosci. 2004 Oct;118(5):916-24 [15506874] J Consult Clin Psychol. 1982 Feb;50(1):71-86 [7056922] Behav Neurosci. 1986 Dec;100(6):814-24 [3545257] Psychophysiology. 1987 May;24(3):278-85 [3602283] Addict Behav. 1987;12(2):195-8 [3630806] J Abnorm Psychol. 1988 Aug;97(3):346-53 [3192830] Psychophysiology. 1989 May;26(3):311-20 [2756080] J Behav Med. 1989 Apr;12(2):159-82 [2668531] Psychopharmacology (Berl). 1992;108(4):485-94 [1410164] Biol Psychiatry. 1993 Aug 15;34(4):253-60 [8399822] Biol Psychol. 1993 Jul;35(3):185-200 [8218613] Psychopharmacology (Berl). 1994 Mar;114(2):369-74 [7838931] Addiction. 1994 Nov;89(11):1461-70 [7841857] Behav Genet. 1995 Mar;25(2):133-47 [7733855] Behav Genet. 1995 Mar;25(2):95-101 [7733862] Psychopharmacology (Berl). 1996 Nov;128(1):54-60 [8944406] Nature. 1998 Jun 4;393(6684):467-70 [9624001] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. AN - 68428336; 17725985 AB - Mitochondrial DNA is replicated and repaired by DNA polymerase gamma (pol gamma), encoded by the POLG gene. The Y955C substitution in POLG leads to autosomal dominant progressive external ophthalmoplegia (PEO) with other severe phenotypes. PEO patients with this mutation can further develop parkinsonism or premature ovarian failure. Mouse and yeast models with this mutation show enhanced amounts of oxidative lesions and increased mtDNA damage. In DNA pol gamma, Tyr955 plays a critical role in catalysis and high fidelity DNA synthesis. 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most common oxidative lesions in DNA and can promote transversion mutations. Mitochondria are thought to be a major source of endogenous reactive oxygen species that can react with dG to form 8-oxo-dG as one of the more common products. DNA polymerases can mitigate mutagenesis by 8-oxo-dG through allosteric interactions from amino acid side chains, which limit the anti-conformation of the 8-oxo-dG template base during translesion DNA synthesis. Here, we show that the Y955C pol gamma displays relaxed discrimination when either incorporating 8-oxo-dGTP or translesion synthesis opposite 8-oxo-dG. Molecular modeling and biochemical analysis suggest that this residue, Tyr955, in conjunction with Phe961 helps attenuate the anti-conformation in human pol gamma for error free bypass of 8-oxo-dG and substitution to Cys allows the mutagenic syn conformation. Collectively, these results offer a biochemical link between the observed oxidative stress in model systems and parkinsonism in patients, suggesting that patients harboring the Y955C POLG mutation may undergo enhanced oxidative stress and DNA mutagenesis. JF - Human molecular genetics AU - Graziewicz, Maria A AU - Bienstock, Rachelle J AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2729 EP - 2739 VL - 16 IS - 22 SN - 0964-6906, 0964-6906 KW - 8-oxo-7-hydrodeoxyguanosine KW - 88847-89-6 KW - DNA KW - 9007-49-2 KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Models, Molecular KW - Humans KW - Oxidative Stress KW - Deoxyguanosine -- metabolism KW - DNA Replication -- genetics KW - DNA -- genetics KW - Ophthalmoplegia, Chronic Progressive External -- genetics KW - Ophthalmoplegia, Chronic Progressive External -- enzymology KW - DNA -- chemistry KW - Deoxyguanosine -- genetics KW - Parkinsonian Disorders -- enzymology KW - Mutation KW - Parkinsonian Disorders -- genetics KW - DNA-Directed DNA Polymerase -- genetics KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68428336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=The+DNA+polymerase+gamma+Y955C+disease+variant+associated+with+PEO+and+parkinsonism+mediates+the+incorporation+and+translesion+synthesis+opposite+7%2C8-dihydro-8-oxo-2%27-deoxyguanosine.&rft.au=Graziewicz%2C+Maria+A%3BBienstock%2C+Rachelle+J%3BCopeland%2C+William+C&rft.aulast=Graziewicz&rft.aufirst=Maria&rft.date=2007-11-15&rft.volume=16&rft.issue=22&rft.spage=2729&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 1999 May;154(5):1423-9 [10329595] Mutat Res. 1999 Jul 30;434(3):137-48 [10486588] Arch Neurol. 2004 Nov;61(11):1777-9 [15534189] Neurobiol Dis. 2005 Feb;18(1):19-31 [15649693] Nat Genet. 2006 May;38(5):515-7 [16604074] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R244-52 [16987890] Hum Reprod. 2006 Oct;21(10):2467-73 [16595552] Protein Sci. 2006 Nov;15(11):2507-24 [17075131] Neurology. 2006 Nov 14;67(9):1698-700 [16943369] J Biol Chem. 2006 Nov 24;281(47):36241-8 [17005553] Mitochondrion. 2007 Feb-Apr;7(1-2):58-62 [17300997] Lab Invest. 2007 Apr;87(4):326-35 [17310215] J Neurosci Res. 2007 Apr;85(5):919-34 [17279544] Biophys J. 2007 May 1;92(9):3063-70 [17293403] Brain. 2006 Jul;129(Pt 7):1637-9 [16803839] Ann Neurol. 1999 Dec;46(6):920-4 [10589547] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Mol Biol. 2000 Sep 8;302(1):205-17 [10964570] Free Radic Biol Med. 2000 Aug;29(3-4):357-67 [11035265] J Biol Chem. 2001 Jun 29;276(26):23616-23 [11319228] Nat Genet. 2001 Jul;28(3):211-2 [11431686] Mol Cell Biol. 2005 Jun;25(12):5196-204 [15923634] Gene. 2005 Jul 18;354:125-31 [15913923] Structure. 2005 Nov;13(11):1653-9 [16271888] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] J Biol Chem. 2003 Sep 5;278(36):33701-7 [12819227] Nucleic Acids Res. 2004;32(1):397-405 [14729924] Nucleic Acids Res. 2004;32(10):3053-64 [15181170] Annu Rev Biochem. 2004;73:293-320 [15189144] Nat Struct Mol Biol. 2004 Aug;11(8):770-6 [15258572] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Lancet. 2004 Sep 4-10;364(9437):875-82 [15351195] Nature. 2004 Sep 9;431(7005):217-21 [15322558] J Neurochem. 1986 May;46(5):1501-7 [3485701] J Biol Chem. 1987 Oct 25;262(30):14689-96 [3667598] J Biol Chem. 1990 Nov 25;265(33):20302-7 [1700787] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nature. 1992 Mar 5;356(6364):83-5 [1538787] J Mol Biol. 1993 Sep 5;233(1):123-38 [8377180] Neurology. 1993 Nov;43(11):2170-2 [8232923] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] Biochemistry. 1994 Apr 19;33(15):4695-701 [8161527] J Biol Chem. 1995 Apr 21;270(16):9202-6 [7721837] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Cell Death Differ. 2006 Apr;13(4):551-63 [16273081] Biol Chem. 2006 Apr;387(4):373-9 [16606334] Ann Neurol. 2006 May;59(5):859-62 [16634032] Nat Genet. 2006 May;38(5):518-20 [16604072] Cancer Res. 2001 Jul 15;61(14):5378-81 [11454679] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2001 Nov 2;276(44):40847-57 [11526116] Free Radic Biol Med. 2002 May 1;32(9):804-12 [11978482] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Mol Cell Biol. 2002 Jun;22(12):4086-93 [12024022] Ann Neurol. 2002 Aug;52(2):211-9 [12210792] Arch Neurol. 2002 Oct;59(10):1541-50 [12374491] Structure. 2003 Jan;11(1):121-7 [12517346] J Biol Chem. 1995 Jun 16;270(24):14659-65 [7782328] Nature. 1996 May 23;381(6580):272 [8692262] Biochemistry. 1997 May 27;36(21):6475-87 [9174365] J Neurochem. 1997 Sep;69(3):1196-203 [9282943] Biochemistry. 1998 Mar 10;37(10):3567-74 [9521678] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Bioinformatics. 1998;14(6):523-8 [9694991] Mutat Res. 1999 Mar 8;424(1-2):51-8 [10064849] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways. AN - 68335499; 17657738 AB - Interferon alpha (IFNalpha) induces an EGF-Ras-->Raf-1-->Erk dependent survival pathway counteracting apoptosis induced by the cytokine. In this paper we have evaluated the effects of the combination between farnesyl-transferase inhibitor (FTI) R115777 and IFNalpha on the growth inhibition and apoptosis of cancer cells. Simultaneous exposure to R115777 and IFNalpha produced synergistic both antiproliferative and proapoptotic effects. In these experimental conditions, IFNalpha and R115777 completely antagonized the increased activity of both Ras and Erk-1/2 induced by IFNalpha and strongly reduced Akt activity. Furthermore, treatment with R115777 in combination with IFNalpha regimen induced tumor growth delay on established KB cell xenografts in nude mice, while the single agents were almost inactive. R115777 was again able to antagonize the Ras-dependent survival pathway induced by IFNalpha also in vivo. Raf-1, one of the downstream targets of Ras, has been reported to activate bcl-2 through displacement and/or phosphorylation of Bad. We have found that IFNalpha induced mitochondrial localization of Raf-1 that was antagonized by R115777. Moreover, IFNalpha increased Raf-1/bcl-2 immuno-conjugate formation and intracellular co-localization and enhanced phosphorylation of Bad at Ser 112 and again R115777 counteracted all these effects. Moreover, the use of plasmids encoding for dominant negative or dominant positive Raf-1 antagonized and potentiated, respectively, the co-immunoprecipitation between Raf-1 and bcl-2. In conclusion, FTI R115777 strongly potentiates the antitumor activity of IFNalpha both in vitro and in vivo through the inhibition of different survival pathways that are dependent from isoprenylation of intracellular proteins such as ras. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Caraglia, Michele AU - Marra, Monica AU - Viscomi, Caterina AU - D'Alessandro, Anna Maria AU - Budillon, Alfredo AU - Meo, Giuseppina AU - Arra, Claudio AU - Barbieri, Antonio AU - Rapp, Ulf R AU - Baldi, Alfonso AU - Tassone, Pierfrancesco AU - Venuta, Salvatore AU - Abbruzzese, Alberto AU - Tagliaferri, Pierosandro AD - Experimental Pharmacology Unit, Experimental Oncology Department, National Cancer Institute Fondazione "G. Pascale", Naples, Italy. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2317 EP - 2330 VL - 121 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Interferon-alpha KW - Proto-Oncogene Proteins c-bcl-2 KW - Quinolones KW - Phosphoserine KW - 17885-08-4 KW - Farnesyltranstransferase KW - EC 2.5.1.29 KW - Proto-Oncogene Proteins c-raf KW - EC 2.7.11.1 KW - ras Proteins KW - EC 3.6.5.2 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Animals KW - Humans KW - Proto-Oncogene Proteins c-raf -- metabolism KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Mice, Inbred BALB C KW - Phosphoserine -- metabolism KW - Neoplasms -- pathology KW - Cell Survival -- drug effects KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Mitochondria -- drug effects KW - Antineoplastic Agents -- toxicity KW - Xenograft Model Antitumor Assays KW - Mitochondria -- metabolism KW - ras Proteins -- metabolism KW - Antineoplastic Agents -- therapeutic use KW - Immunohistochemistry KW - Female KW - Protein Transport KW - Neoplasms -- metabolism KW - Quinolones -- toxicity KW - Interferon-alpha -- pharmacology KW - Interferon-alpha -- metabolism KW - Quinolones -- therapeutic use KW - Farnesyltranstransferase -- metabolism KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68335499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=The+farnesyltransferase+inhibitor+R115777+%28ZARNESTRA%29+enhances+the+pro-apoptotic+activity+of+interferon-alpha+through+the+inhibition+of+multiple+survival+pathways.&rft.au=Caraglia%2C+Michele%3BMarra%2C+Monica%3BViscomi%2C+Caterina%3BD%27Alessandro%2C+Anna+Maria%3BBudillon%2C+Alfredo%3BMeo%2C+Giuseppina%3BArra%2C+Claudio%3BBarbieri%2C+Antonio%3BRapp%2C+Ulf+R%3BBaldi%2C+Alfonso%3BTassone%2C+Pierfrancesco%3BVenuta%2C+Salvatore%3BAbbruzzese%2C+Alberto%3BTagliaferri%2C+Pierosandro&rft.aulast=Caraglia&rft.aufirst=Michele&rft.date=2007-11-15&rft.volume=121&rft.issue=10&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Int J Cancer. 2008 Apr 15;122(8):1922 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. AN - 70054262; 18001477 AB - Meta-analyses of N-acetylcysteine (NAC) for preventing contrast-induced nephrotoxicity (CIN) have led to disparate conclusions. Here we examine and attempt to resolve the heterogeneity evident among these trials. Two reviewers independently extracted and graded the data. Limiting studies to randomized, controlled trials with adequate outcome data yielded 22 reports with 2746 patients. Significant heterogeneity was detected among these trials (I2 = 37%; p = 0.04). Meta-regression analysis failed to identify significant sources of heterogeneity. A modified L'Abbé plot that substituted groupwise changes in serum creatinine for nephrotoxicity rates, followed by model-based, unsupervised clustering resolved trials into two distinct, significantly different (p 0.5, for both). Cluster 1 studies (n = 18; 2445 patients) showed no benefit (relative risk (RR) = 0.87; 95% confidence interval (CI) 0.68-1.12, p = 0.28), while cluster 2 studies (n = 4; 301 patients) indicated that NAC was highly beneficial (RR = 0.15; 95% CI 0.07-0.33, p < 0.0001). Benefit in cluster 2 was unexpectedly associated with NAC-induced decreases in creatinine from baseline (p = 0.07). Cluster 2 studies were relatively early, small and of lower quality compared with cluster 1 studies (p = 0.01 for the three factors combined). Dialysis use across all studies (five control, eight treatment; p = 0.42) did not suggest that NAC is beneficial. This meta-analysis does not support the efficacy of NAC to prevent CIN. JF - BMC medicine AU - Gonzales, Denise A AU - Norsworthy, Kelly J AU - Kern, Steven J AU - Banks, Steve AU - Sieving, Pamela C AU - Star, Robert A AU - Natanson, Charles AU - Danner, Robert L AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. dgonzales@cc.nih.gov Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 32 VL - 5 KW - Contrast Media KW - 0 KW - Creatinine KW - AYI8EX34EU KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Sensitivity and Specificity KW - Regression Analysis KW - Randomized Controlled Trials as Topic KW - Humans KW - Aged KW - Renal Dialysis KW - Models, Biological KW - Creatinine -- metabolism KW - Risk Factors KW - Publication Bias KW - Middle Aged KW - Cluster Analysis KW - Female KW - Male KW - Contrast Media -- adverse effects KW - Kidney Diseases -- prevention & control KW - Acetylcysteine -- pharmacology KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70054262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medicine&rft.atitle=A+meta-analysis+of+N-acetylcysteine+in+contrast-induced+nephrotoxicity%3A+unsupervised+clustering+to+resolve+heterogeneity.&rft.au=Gonzales%2C+Denise+A%3BNorsworthy%2C+Kelly+J%3BKern%2C+Steven+J%3BBanks%2C+Steve%3BSieving%2C+Pamela+C%3BStar%2C+Robert+A%3BNatanson%2C+Charles%3BDanner%2C+Robert+L&rft.aulast=Gonzales&rft.aufirst=Denise&rft.date=2007-11-14&rft.volume=5&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=BMC+medicine&rft.issn=1741-7015&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nephrol Dial Transplant. 2006 Jul;21(7):1863-9 [16522657] N Engl J Med. 2006 Jun 29;354(26):2773-82 [16807414] Kardiol Pol. 2006 Jun;64(6):559-64; discussion 565-6 [16810570] Radiology. 2006 Aug;240(2):615; author reply 615 [16864687] Int J Cardiol. 2007 Jan 31;115(1):57-62 [16814414] Am Heart J. 2007 Sep;154(3):539-44 [17719303] J Am Soc Nephrol. 2004 Feb;15(2):251-60 [14747371] J Am Soc Nephrol. 2004 Feb;15(2):407-10 [14747387] Eur Heart J. 2004 Feb;25(3):206-11 [14972420] Eur Heart J. 2004 Feb;25(3):212-8 [14972421] J Am Soc Nephrol. 2004 Mar;15(3):761-9 [14978179] Kidney Int. 2004 Apr;65(4):1366-74 [15086476] WMJ. 2004;103(1):38-41 [15101466] Am J Kidney Dis. 2004 May;43(5):801-8 [15112170] JAMA. 2004 May 19;291(19):2328-34 [15150204] Nephrol Dial Transplant. 2004 Jul;19(7):1803-7 [15128882] J Interv Cardiol. 2004 Jun;17(3):159-65 [15209578] Arch Mal Coeur Vaiss. 2003 Dec;96(12):1157-61 [15248440] Kidney Blood Press Res. 2004;27(3):161-6 [15256811] J Am Coll Cardiol. 2004 Aug 18;44(4):762-5 [15312855] Clin Nephrol. 2004 Aug;62(2):77-83 [15356963] Am Heart J. 2006 Jan;151(1):140-5 [16368307] Am Heart J. 2004 Sep;148(3):422-9 [15389228] Am Heart J. 2004 Oct;148(4):690-5 [15459602] J Am Coll Cardiol. 2004 Oct 6;44(7):1393-9 [15464318] AJR Am J Roentgenol. 1981 May;136(5):859-61 [6784516] Ann Intern Med. 1987 Aug;107(2):224-33 [3300460] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] Biometrics. 1994 Dec;50(4):1088-101 [7786990] BMJ. 1995 Sep 16;311(7007):753-4 [7549720] JAMA. 1996 May 15;275(19):1489-94 [8622223] Control Clin Trials. 1996 Feb;17(1):1-12 [8721797] N Engl J Med. 1997 Aug 21;337(8):536-42 [9262498] BMJ. 1997 Sep 13;315(7109):629-34 [9310563] Am J Med. 1997 Nov;103(5):368-75 [9375704] BMJ. 1998 Jan 17;316(7126):221-5 [9468698] Clin Cardiol. 2004 Nov;27(11):607-10 [15562929] BMC Med. 2004 Oct 22;2:38 [15500690] J Vasc Surg. 2004 Dec;40(6):1136-41 [15622367] Am J Med. 2004 Dec 15;117(12):938-47 [15629733] J Invasive Cardiol. 2005 Feb;17(2):80-4 [15687530] Catheter Cardiovasc Interv. 2005 Apr;64(4):471-9 [15789388] J Gen Intern Med. 2005 Feb;20(2):193-200 [15836554] Lancet. 1999 Nov 27;354(9193):1896-900 [10584742] N Engl J Med. 2000 Jul 20;343(3):180-4 [10900277] Stat Med. 2000 Dec 15;19(23):3251-74 [11113958] Am J Cardiol. 2002 Feb 1;89(3):356-8 [11809444] Arch Intern Med. 2002 Feb 11;162(3):329-36 [11822926] Clin Chem. 2002 May;48(5):699-707 [11978596] J Am Coll Cardiol. 2002 Jul 17;40(2):298-303 [12106935] Stat Med. 2002 Jun 15;21(11):1539-58 [12111919] J Am Coll Cardiol. 2002 Oct 16;40(8):1383-8 [12392825] Am J Respir Crit Care Med. 2002 Nov 1;166(9):1197-205 [12403688] Catheter Cardiovasc Interv. 2002 Nov;57(3):279-83 [12410497] Kidney Int. 2002 Dec;62(6):2202-7 [12427146] G Ital Nefrol. 2002 Sep-Oct;19(5):529-33 [12439841] JAMA. 2003 Feb 5;289(5):553-8 [12578487] Catheter Cardiovasc Interv. 2003 Mar;58(3):336-41 [12594698] J Invasive Cardiol. 2003 Jun;15(6):311-4 [12777667] J Am Coll Cardiol. 2003 Jun 18;41(12):2114-8 [12821233] Lancet. 2003 Aug 23;362(9384):598-603 [12944058] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] Metabolism. 2003 Oct;52(10):1258-64 [14564676] Am J Health Syst Pharm. 2003 Nov 1;60(21):2232-5 [14619114] Catheter Cardiovasc Interv. 2003 Dec;60(4):458-61 [14624421] Kidney Int. 2003 Dec;64(6):2182-7 [14633141] Am Heart J. 2003 Dec;146(6):E23 [14661012] Am J Cardiol. 2003 Dec 15;92(12):1454-8 [14675586] Am J Kidney Dis. 2004 Jan;43(1):1-9 [14712421] Acta Cardiol. 2003 Dec;58(6):555-60 [14713182] Heart. 2005 Jun;91(6):774-8 [15894775] JAMA. 2005 Jul 20;294(3):342-50 [16030279] J Cardiovasc Pharmacol. 2005 Oct;46(4):464-7 [16160598] Rev Fac Cien Med Univ Nac Cordoba. 2004;61(2):13-9 [16211988] Heart Lung Circ. 2005 Dec;14(4):245-51 [16360994] Arch Intern Med. 2006 Jan 23;166(2):161-6 [16432083] BMJ. 2006 Jan 28;332(7535):202-9 [16415336] J Lab Clin Med. 2006 Jan;147(1):7-20 [16443000] Cardiovasc Intervent Radiol. 2006 May-Jun;29(3):344-7 [16502177] Am Heart J. 2006 May;151(5):1032.e9-12 [16644332] Int J Cardiol. 2006 May 24;109(3):322-8 [16039733] Ren Fail. 2006;28(3):265-6 [16703801] Radiology. 2006 Jun;239(3):793-804 [16714461] Anesth Analg. 2006 Jun;102(6):1638-45 [16717300] JAMA. 2006 Jun 21;295(23):2765-79 [16788132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. AN - 68512482; 18003850 AB - The value of rewards (natural rewards and drugs) is associated with dopamine increases in the nucleus accumbens and varies as a function of context. The prefrontal cortex has been implicated in the context dependency of rewards and in the fixated high value that drugs have in addiction, although the mechanisms are not properly understood. Here we test the hypothesis that the prefrontal cortex regulates the value of rewards by modulating dopamine increases in nucleus accumbens and that this regulation is disrupted in addicted subjects. We used positron emission tomography to evaluate the activity of the prefrontal cortex (measuring brain glucose metabolism with [18F]fluorodeoxyglucose) and dopamine increases (measured with [11C]raclopride, a D2/D3 receptor ligand with binding that is sensitive to endogenous dopamine) induced by the stimulant drug methylphenidate in 20 controls and 20 detoxified alcoholics, most of whom smoked. In all subjects, methylphenidate significantly increased dopamine in striatum. In ventral striatum (where the nucleus accumbens is located) and in putamen, dopamine increases were associated with the rewarding effects of methylphenidate (drug liking and high) and were profoundly attenuated in alcoholics (70 and 50% lower than controls, respectively). In controls, but not in alcoholics, metabolism in orbitofrontal cortex (region involved with salience attribution) was negatively associated with methylphenidate-induced dopamine increases in ventral striatum. These results are consistent with the hypothesis that the orbitofrontal cortex modulates the value of rewards by regulating the magnitude of dopamine increases in the ventral striatum and that disruption of this regulation may underlie the decreased sensitivity to rewards in addicted subjects. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Logan, Jean AU - Jayne, Millard AU - Ma, Yeming AU - Pradhan, Kith AU - Wong, Christopher AD - National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. nvolkow@nida.nih.gov Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12700 EP - 12706 VL - 27 IS - 46 KW - Central Nervous System Depressants KW - 0 KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - Methylphenidate KW - 207ZZ9QZ49 KW - Ethanol KW - 3K9958V90M KW - Raclopride KW - 430K3SOZ7G KW - Glucose KW - IY9XDZ35W2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Neural Pathways -- physiopathology KW - Positron-Emission Tomography KW - Alcoholism -- diagnostic imaging KW - Methylphenidate -- pharmacology KW - Neural Pathways -- metabolism KW - Humans KW - Brain Chemistry -- drug effects KW - Glucose -- metabolism KW - Alcoholism -- metabolism KW - Neural Pathways -- drug effects KW - Down-Regulation -- physiology KW - Central Nervous System Depressants -- adverse effects KW - Adult KW - Middle Aged KW - Alcoholism -- physiopathology KW - Down-Regulation -- drug effects KW - Male KW - Brain Chemistry -- physiology KW - Dopamine Uptake Inhibitors -- pharmacology KW - Ethanol -- adverse effects KW - Alcohol-Induced Disorders, Nervous System -- metabolism KW - Corpus Striatum -- physiopathology KW - Reward KW - Prefrontal Cortex -- metabolism KW - Corpus Striatum -- metabolism KW - Prefrontal Cortex -- physiopathology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Prefrontal Cortex -- drug effects KW - Alcohol-Induced Disorders, Nervous System -- physiopathology KW - Alcohol-Induced Disorders, Nervous System -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68512482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Profound+decreases+in+dopamine+release+in+striatum+in+detoxified+alcoholics%3A+possible+orbitofrontal+involvement.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BJayne%2C+Millard%3BMa%2C+Yeming%3BPradhan%2C+Kith%3BWong%2C+Christopher&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12700&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. AN - 68509434; 18003845 AB - In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuated by inhibition of glutamate transmission in the ventral tegmental area and medial accumbens shell, components of the mesolimbic dopamine system. Here, we explored the role of dopamine of the accumbens in context-induced reinstatement by using the D1-family receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride]. Rats were trained to self-administer heroin for 12 d; drug infusions were paired with a discrete tone-light cue. Subsequently, the heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. When tested in the original drug self-administration context, systemic and medial or lateral accumbens shell SCH 23390 injections attenuated context-induced reinstatement of heroin seeking, whereas accumbens core SCH 23390 injections were ineffective. In contrast, core but not lateral or medial shell SCH 23390 injections attenuated discrete-cue-induced reinstatement in a nondrug context after extinction of lever presses without this cue. Results indicate that activation of medial and lateral accumbens shell D1-family dopamine receptors mediate context-induced reinstatement of heroin seeking and provide the first demonstration for a role of lateral shell dopamine in conditioned drug effects. Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bossert, Jennifer M AU - Poles, Gabriela C AU - Wihbey, Kristina A AU - Koya, Eisuke AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12655 EP - 12663 VL - 27 IS - 46 KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine D1 KW - Index Medicus KW - Animals KW - Benzazepines -- pharmacology KW - Rats, Long-Evans KW - Disease Models, Animal KW - Extinction, Psychological -- physiology KW - Conditioning (Psychology) -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Conditioning (Psychology) -- physiology KW - Cues KW - Behavior, Animal -- physiology KW - Benzazepines -- therapeutic use KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Male KW - Reward KW - Heroin Dependence -- metabolism KW - Dopamine Antagonists -- therapeutic use KW - Nucleus Accumbens -- drug effects KW - Receptors, Dopamine D1 -- antagonists & inhibitors KW - Heroin Dependence -- physiopathology KW - Dopamine Antagonists -- pharmacology KW - Heroin Dependence -- prevention & control KW - Nucleus Accumbens -- metabolism KW - Behavior, Addictive -- physiopathology KW - Nucleus Accumbens -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68509434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Differential+effects+of+blockade+of+dopamine+D1-family+receptors+in+nucleus+accumbens+core+or+shell+on+reinstatement+of+heroin+seeking+induced+by+contextual+and+discrete+cues.&rft.au=Bossert%2C+Jennifer+M%3BPoles%2C+Gabriela+C%3BWihbey%2C+Kristina+A%3BKoya%2C+Eisuke%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12655&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Behav Neurosci. 1999 Apr;113(2):324-36 [10357457] Brain Res Rev. 2007 Nov;56(1):27-78 [17574681] Psychopharmacology (Berl). 2004 Nov;176(3-4):459-65 [15138757] J Neurosci. 2004 Nov 24;24(47):10726-30 [15564590] Neuropsychopharmacology. 2005 Feb;30(2):296-309 [15483559] Neuron. 2005 Mar 3;45(5):647-50 [15748840] J Neurosci. 2005 May 18;25(20):5061-5 [15901788] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Feb;31(2):363-74 [15957007] Neuroscience. 2006;139(3):877-87 [16516392] Psychopharmacology (Berl). 2006 Aug;187(2):143-53 [16724186] Neuropsychopharmacology. 2006 Oct;31(10):2197-209 [16341024] Psychopharmacology (Berl). 2006 Nov;189(1):1-16 [17019567] Neuroscience. 2006 Nov 17;143(1):25-38 [16949214] Neuropsychopharmacology. 2008 May;33(6):1402-12 [17653111] Neuropsychopharmacology. 2008 May;33(6):1413-25 [17712353] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4321-6 [10760299] Neuroscience. 2000;99(2):267-77 [10938432] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1976-81 [11172061] Psychopharmacology (Berl). 2001 Jun;156(1):98-107 [11465640] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuropsychopharmacology. 2001 Sep;25(3):361-72 [11522464] J Neurosci. 2001 Dec 1;21(23):9471-7 [11717381] Pharmacol Biochem Behav. 2002 Mar;71(3):517-29 [11830186] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Behav Neurosci. 2002 Feb;116(1):169-73 [11895178] Psychopharmacology (Berl). 2002 Apr;160(4):425-33 [11919670] J Neurosci. 2002 May 1;22(9):3312-20 [11978805] Neurosci Biobehav Rev. 2002 May;26(3):321-52 [12034134] Biol Psychiatry. 2002 Nov 15;52(10):976-86 [12437938] Neuropsychopharmacology. 2002 Dec;27(6):1006-15 [12464457] Neuropsychopharmacology. 2003 Feb;28(2):292-9 [12589382] Psychopharmacology (Berl). 2003 Jul;168(1-2):132-8 [12491029] J Neurosci. 2003 Jul 16;23(15):6295-303 [12867514] J Neurosci. 2003 Aug 13;23(19):7239-45 [12917356] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Neurosci Biobehav Rev. 2004 Jan;27(8):765-76 [15019426] Nat Neurosci. 2004 Apr;7(4):389-97 [15034590] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Trends Neurosci. 2004 Aug;27(8):468-74 [15271494] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Neuropharmacology. 2004;47 Suppl 1:227-41 [15464140] Arch Gen Psychiatry. 1973 May;28(5):611-6 [4700675] Brain Res. 1975 Mar 28;86(3):399-418 [234776] Pharmacol Rev. 1975 Sep;27(3):325-40 [817305] J Comp Neurol. 1978 Aug 1;180(3):545-80 [659674] Eur J Pharmacol. 1986 Oct 7;129(3):367-70 [3536532] Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):252-8 [2725702] J Comp Neurol. 1989 Nov 8;289(2):189-201 [2478598] Br J Pharmacol. 1991 Dec;104(4):1038-44 [1687364] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Neuroscience. 1992 Sep;50(1):149-62 [1383869] Neuroscience. 1992 Oct;50(4):751-67 [1448200] Brain Res. 1995 Sep 18;692(1-2):47-56 [8548319] J Neurosci. 1996 Mar 1;16(5):1957-63 [8774462] Eur J Neurosci. 1997 Dec;9(12):2541-8 [9517459] Neuroscience. 1999 Mar;89(2):473-89 [10077329] Psychopharmacology (Berl). 2007 Apr;191(3):689-703 [17072592] Neuroscience. 2007 May 11;146(2):525-36 [17360123] Ann N Y Acad Sci. 1999 Jun 29;877:140-56 [10415648] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Oxidative Interaction between RNA and Cytochrome C T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40706642; 4755938 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Tanaka, Mikiei AU - Chock, P Boon AU - Stadtman, Earl Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cytochrome c KW - RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Oxidative+Interaction+between+RNA+and+Cytochrome+C&rft.au=Tanaka%2C+Mikiei%3BChock%2C+P+Boon%3BStadtman%2C+Earl&rft.aulast=Tanaka&rft.aufirst=Mikiei&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photo-Induced Reactive Oxygen Species Generation and Cytotoxicity of different Water-Soluble Fullerenes in Human HaCaT Keratinocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40706536; 4755815 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Zhao, Baozhong AU - Bilski, Piotr AU - He, Yu-Ying AU - Feng, Li AU - Chignell, Colin Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Reactive oxygen species KW - Cytotoxicity KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Photo-Induced+Reactive+Oxygen+Species+Generation+and+Cytotoxicity+of+different+Water-Soluble+Fullerenes+in+Human+HaCaT+Keratinocytes&rft.au=Zhao%2C+Baozhong%3BBilski%2C+Piotr%3BHe%2C+Yu-Ying%3BFeng%2C+Li%3BChignell%2C+Colin&rft.aulast=Zhao&rft.aufirst=Baozhong&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Inflammation and Cancer: Influence of Nitric Oxide T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705550; 4755883 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Hussain, S Perwez AU - He, Peijun AU - Subleski, Jeffery AU - Hofseth, Lorne AU - Trivers, Glennwood AU - Mechanic, Leah AU - Bailey, Anne AU - Bernard, Mark AU - Schwank, Jonathan AU - Djurickovic, Draginja AU - Haines, Diana AU - Weiss, Jonathan AU - Laubach, Victor AU - Back, Timothy AU - Wiltrout, Robert AU - Harris, Curtis Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cancer KW - Nitric oxide KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Chronic+Inflammation+and+Cancer%3A+Influence+of+Nitric+Oxide&rft.au=Hussain%2C+S+Perwez%3BHe%2C+Peijun%3BSubleski%2C+Jeffery%3BHofseth%2C+Lorne%3BTrivers%2C+Glennwood%3BMechanic%2C+Leah%3BBailey%2C+Anne%3BBernard%2C+Mark%3BSchwank%2C+Jonathan%3BDjurickovic%2C+Draginja%3BHaines%2C+Diana%3BWeiss%2C+Jonathan%3BLaubach%2C+Victor%3BBack%2C+Timothy%3BWiltrout%2C+Robert%3BHarris%2C+Curtis&rft.aulast=Hussain&rft.aufirst=S&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mitochondrially-Targeted Redox Agent Mitoquinone Enhances Doxorubicin-Induced Toxicity to Breast Cancer Cells While Protecting Cardiac Myocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705413; 4755903 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Rao, V Ashutosh AU - Klein, Sarah AU - Zielonka, Jacek AU - Kalyanaraman, B AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Toxicity KW - Breast cancer KW - Cardiomyocytes KW - Mitochondria KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=The+Mitochondrially-Targeted+Redox+Agent+Mitoquinone+Enhances+Doxorubicin-Induced+Toxicity+to+Breast+Cancer+Cells+While+Protecting+Cardiac+Myocytes&rft.au=Rao%2C+V+Ashutosh%3BKlein%2C+Sarah%3BZielonka%2C+Jacek%3BKalyanaraman%2C+B%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=V&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free Radical Production by Arsenic Trioxide T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705118; 4755919 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Kadiiska, Maria AU - Liu, Jie AU - Waalkes, Mike AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Arsenic trioxide KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Free+Radical+Production+by+Arsenic+Trioxide&rft.au=Kadiiska%2C+Maria%3BLiu%2C+Jie%3BWaalkes%2C+Mike%3BMason%2C+Ronald&rft.aulast=Kadiiska&rft.aufirst=Maria&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascorbic Acid as a Pro-Oxidant Therapeutic Agent in Cancer T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704873; 4755912 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Chen, Qi AU - Sun, Andrew AU - Espey, Michael AU - Levine, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cancer KW - Ascorbic acid KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Ascorbic+Acid+as+a+Pro-Oxidant+Therapeutic+Agent+in+Cancer&rft.au=Chen%2C+Qi%3BSun%2C+Andrew%3BEspey%2C+Michael%3BLevine%2C+Mark&rft.aulast=Chen&rft.aufirst=Qi&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Guanosine Monophosphate, but not Guanosine and its Higher Phosphate Congeners, Mediates Heme-Periphery Electron Transfers in Lactoperoxidase T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704235; 4755470 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bonini, Marcelo AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Phosphate KW - Guanosine KW - Congeners KW - Electron transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Guanosine+Monophosphate%2C+but+not+Guanosine+and+its+Higher+Phosphate+Congeners%2C+Mediates+Heme-Periphery+Electron+Transfers+in+Lactoperoxidase&rft.au=Bonini%2C+Marcelo%3BMason%2C+Ronald&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electron Transfer between a Tyrosyl Radical and a Cysteine Residue in Hemoproteins: Spin Trapping Analysis T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704111; 4755439 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bhattacharjee, Suchandra AU - Deterding, Leesa AU - Jiang, Jinjie AU - Bonini, Marcello AU - Tomer, Kenneth AU - Ramirez, Dario AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Residues KW - Radicals KW - Trapping KW - Cysteine KW - Electron transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Electron+Transfer+between+a+Tyrosyl+Radical+and+a+Cysteine+Residue+in+Hemoproteins%3A+Spin+Trapping+Analysis&rft.au=Bhattacharjee%2C+Suchandra%3BDeterding%2C+Leesa%3BJiang%2C+Jinjie%3BBonini%2C+Marcello%3BTomer%2C+Kenneth%3BRamirez%2C+Dario%3BMason%2C+Ronald&rft.aulast=Bhattacharjee&rft.aufirst=Suchandra&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radical Sites in M. Tuberculosis Katg Identified using Epr Spectroscopy, the 3-D Crystal Structure and Electron-Transfer Couplings T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704094; 4755485 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Ranguelova, Kalina AU - Suarez, Javier AU - Gerfen, Gary AU - Magliozzo, Richard Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Spectroscopy KW - Tuberculosis KW - Radicals KW - Crystal structure KW - Mycobacterium tuberculosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Radical+Sites+in+M.+Tuberculosis+Katg+Identified+using+Epr+Spectroscopy%2C+the+3-D+Crystal+Structure+and+Electron-Transfer+Couplings&rft.au=Ranguelova%2C+Kalina%3BSuarez%2C+Javier%3BGerfen%2C+Gary%3BMagliozzo%2C+Richard&rft.aulast=Ranguelova&rft.aufirst=Kalina&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photocytotoxicity and Photochemistry of the Selective Non-Steroidal Androgen Receptor Modulator Tdpq T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40703473; 4755818 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bilski, Piotr AU - Risek, Boris AU - Chignell, Colin AU - Schrade, William Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Photochemistry KW - Androgen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40703473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Photocytotoxicity+and+Photochemistry+of+the+Selective+Non-Steroidal+Androgen+Receptor+Modulator+Tdpq&rft.au=Bilski%2C+Piotr%3BRisek%2C+Boris%3BChignell%2C+Colin%3BSchrade%2C+William&rft.aulast=Bilski&rft.aufirst=Piotr&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Dependent Nitrite Metabolism and NO Production is Regulated by Oxygen T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40703095; 4755765 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Shiva, Sruti AU - Curtis, Erin AU - Liu, Geng AU - Gladwin, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Nitrite KW - Oxygen KW - Metabolism KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40703095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Tissue+Dependent+Nitrite+Metabolism+and+NO+Production+is+Regulated+by+Oxygen&rft.au=Shiva%2C+Sruti%3BCurtis%2C+Erin%3BLiu%2C+Geng%3BGladwin%2C+Mark&rft.aulast=Shiva&rft.aufirst=Sruti&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis. T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40699004; 4755737 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Siraki, Arno AU - Bonini, Marcelo AU - Jiang, JinJie AU - Ehrenshaft, Marilyn AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Free radicals KW - Neutropenia KW - Peroxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Procainamide%2C+but+not+N-Acetylprocainamide%2C+Induces+Protein+Free+Radical+Formation+on+Myeloperoxidase%3A+A+Potential+Mechanism+of+Agranulocytosis.&rft.au=Siraki%2C+Arno%3BBonini%2C+Marcelo%3BJiang%2C+JinJie%3BEhrenshaft%2C+Marilyn%3BMason%2C+Ronald&rft.aulast=Siraki&rft.aufirst=Arno&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible Nitric Oxide Synthase Overexpression in Diabetic Target Organs Triggers Increased Lipid Peroxidation and Tissue Damage T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698391; 4755662 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Stadler, Krisztian AU - Bonini, Marcelo AU - Dallas, Shannon AU - Radi, Rafael AU - Mason, Ronald AU - Kadiiska, Maria Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Peroxidation KW - Organs KW - Lipid peroxidation KW - Nitric-oxide synthase KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Inducible+Nitric+Oxide+Synthase+Overexpression+in+Diabetic+Target+Organs+Triggers+Increased+Lipid+Peroxidation+and+Tissue+Damage&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo%3BDallas%2C+Shannon%3BRadi%2C+Rafael%3BMason%2C+Ronald%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superoxide Levels and Mitochondrial Function are Regulated by SIRT3 Kristi T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698297; 4755645 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Jacobs, Muldoon AU - Gius, David Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Mitochondria KW - Superoxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Superoxide+Levels+and+Mitochondrial+Function+are+Regulated+by+SIRT3+Kristi&rft.au=Jacobs%2C+Muldoon%3BGius%2C+David&rft.aulast=Jacobs&rft.aufirst=Muldoon&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Key Role of Inducible Nitric Oxide Synthase in Free Radical Production and Protein Oxidation Induced by Ketosis T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698249; 4755661 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Stadler, Krisztian AU - Bonini, Marcelo AU - Mason, Ronald AU - Kadiiska, Maria Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Oxidation KW - Nitric-oxide synthase KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Key+Role+of+Inducible+Nitric+Oxide+Synthase+in+Free+Radical+Production+and+Protein+Oxidation+Induced+by+Ketosis&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo%3BMason%2C+Ronald%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Radical View of Cu, Zn-Superoxide Dismutase-Driven Oxidations: Copper- and Carbonate Radical Anion-Triggered Protein Radical Chemistry T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698156; 4755736 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Ramirez, Dario AU - Gomez-Mejiba, Sandra AU - Corbett, Jean AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Oxidation KW - Radicals KW - Carbonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=A+Radical+View+of+Cu%2C+Zn-Superoxide+Dismutase-Driven+Oxidations%3A+Copper-+and+Carbonate+Radical+Anion-Triggered+Protein+Radical+Chemistry&rft.au=Ramirez%2C+Dario%3BGomez-Mejiba%2C+Sandra%3BCorbett%2C+Jean%3BMason%2C+Ronald&rft.aulast=Ramirez&rft.aufirst=Dario&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Testing the Hypothesis that "Methionine Residues in Proteins are Antioxidants" T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695981; 4755731 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Luo, Shen AU - Levine, Rodney Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Residues KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Testing+the+Hypothesis+that+%22Methionine+Residues+in+Proteins+are+Antioxidants%22&rft.au=Luo%2C+Shen%3BLevine%2C+Rodney&rft.aulast=Luo&rft.aufirst=Shen&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutive Nitric Oxide Synthase Activation is a Significant Route Mediating Nitroglycerin-Induced Vasodilation T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695746; 4755656 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bonini, Marcelo AU - Stadler, Krisztian AU - Silva, Sueli AU - Corbett, Jean AU - Dore, Michael AU - Petranka, John AU - Duma, Danielle AU - Fernandes, Denise AU - Tanaka, Leonardo AU - Laurindo, Francisco AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Nitric-oxide synthase KW - Vasodilation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Constitutive+Nitric+Oxide+Synthase+Activation+is+a+Significant+Route+Mediating+Nitroglycerin-Induced+Vasodilation&rft.au=Bonini%2C+Marcelo%3BStadler%2C+Krisztian%3BSilva%2C+Sueli%3BCorbett%2C+Jean%3BDore%2C+Michael%3BPetranka%2C+John%3BDuma%2C+Danielle%3BFernandes%2C+Denise%3BTanaka%2C+Leonardo%3BLaurindo%2C+Francisco%3BMason%2C+Ronald&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascorbate Transporter SLC23A1 is Essential for Vitamin C Renal Reabsorption and Mediates Tight Control In Vivo T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695458; 4755552 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Tu, Hongbin AU - Corpe, Christopher AU - Wang, Jin AU - Eck, Peter AU - Wang, Yaohui AU - Espey, Michael AU - Faulhaber-Walter, Robert AU - Schnermann, Jurgen AU - Nussbaum, Robert AU - Levine, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Vitamin C KW - Ascorbic acid KW - Reabsorption KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Ascorbate+Transporter+SLC23A1+is+Essential+for+Vitamin+C+Renal+Reabsorption+and+Mediates+Tight+Control+In+Vivo&rft.au=Tu%2C+Hongbin%3BCorpe%2C+Christopher%3BWang%2C+Jin%3BEck%2C+Peter%3BWang%2C+Yaohui%3BEspey%2C+Michael%3BFaulhaber-Walter%2C+Robert%3BSchnermann%2C+Jurgen%3BNussbaum%2C+Robert%3BLevine%2C+Mark&rft.aulast=Tu&rft.aufirst=Hongbin&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of Carbonylated Proteins in E. Coli under Certain Nutrient Conditions: Proteomic Identification T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695142; 4755729 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Noda, Yasuko AU - Berlett, Barbara AU - Stadtman, Earl AU - Aponte, Angel AU - Morgan, Meghan AU - Shen, Rong-Fong Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Carbonyl compounds KW - Nutrients KW - Proteomics KW - Specificity KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Specificity+of+Carbonylated+Proteins+in+E.+Coli+under+Certain+Nutrient+Conditions%3A+Proteomic+Identification&rft.au=Noda%2C+Yasuko%3BBerlett%2C+Barbara%3BStadtman%2C+Earl%3BAponte%2C+Angel%3BMorgan%2C+Meghan%3BShen%2C+Rong-Fong&rft.aulast=Noda&rft.aufirst=Yasuko&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Blood gene expression signatures predict exposure levels. AN - 68504838; 17984051 AB - To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S. We hypothesized that gene expression patterns derived from blood cells would provide useful indicators of acute exposure levels. To test this hypothesis, we used a blood gene expression data set from rats exposed to APAP to train classifiers in two prediction algorithms and to extract patterns for prediction using a profiling algorithm. Prediction accuracy was tested on a blinded, independent rat blood test data set and ranged from 88.9% to 95.8%. Genomic markers outperformed predictions based on traditional clinical parameters. The expression profiles of the predictor genes from the patterns extracted from the blood exhibited remarkable (97% accuracy) transtissue APAP exposure prediction when liver gene expression data were used as a test set. Analysis of human samples revealed separation of APAP-intoxicated patients from control individuals based on blood expression levels of human orthologs of the rat discriminatory genes. The major biological signal in the discriminating genes was activation of an inflammatory response after exposure to toxic doses of APAP. These results support the hypothesis that gene expression data from peripheral blood cells can provide valuable information about exposure levels, well before liver damage is detected by classical parameters. It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Bushel, P R AU - Heinloth, A N AU - Li, J AU - Huang, L AU - Chou, J W AU - Boorman, G A AU - Malarkey, D E AU - Houle, C D AU - Ward, S M AU - Wilson, R E AU - Fannin, R D AU - Russo, M W AU - Watkins, P B AU - Tennant, R W AU - Paules, R S AD - Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, **Cancer Biology Group, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709. Y1 - 2007/11/13/ PY - 2007 DA - 2007 Nov 13 SP - 18211 EP - 18216 VL - 104 IS - 46 KW - Acetaminophen KW - 362O9ITL9D KW - L-Iditol 2-Dehydrogenase KW - EC 1.1.1.14 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Alanine Transaminase -- metabolism KW - Algorithms KW - L-Iditol 2-Dehydrogenase -- metabolism KW - Male KW - Leukocyte Count KW - Blood KW - Gene Expression KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68504838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Blood+gene+expression+signatures+predict+exposure+levels.&rft.au=Bushel%2C+P+R%3BHeinloth%2C+A+N%3BLi%2C+J%3BHuang%2C+L%3BChou%2C+J+W%3BBoorman%2C+G+A%3BMalarkey%2C+D+E%3BHoule%2C+C+D%3BWard%2C+S+M%3BWilson%2C+R+E%3BFannin%2C+R+D%3BRusso%2C+M+W%3BWatkins%2C+P+B%3BTennant%2C+R+W%3BPaules%2C+R+S&rft.aulast=Bushel&rft.aufirst=P&rft.date=2007-11-13&rft.volume=104&rft.issue=46&rft.spage=18211&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE5652; GEO N1 - SuppNotes - Cited By: Cell. 2000 Jul 7;102(1):109-26 [10929718] Toxicol Pathol. 2006;34(7):921-8 [17178692] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] Digestion. 2003;67(3):138-45 [12853725] Rofo. 2003 Aug;175(8):1112-9 [12886481] Exp Mol Pathol. 2003 Dec;75(3):187-93 [14611809] Bioinformatics. 2004 Jul 10;20(10):1535-45 [14962920] Eur J Gastroenterol Hepatol. 2005 Feb;17(2):141-3 [15674089] Bioinformatics. 2005 Mar 1;21(5):631-43 [15374862] Physiol Genomics. 2005 Mar 21;21(1):92-104 [15781589] J Bioinform Comput Biol. 2005 Apr;3(2):225-41 [15852502] Clin Ther. 2005 Mar;27(3):336-41 [15878387] Bioinformatics. 2005 Aug 1;21(15):3301-7 [15905277] Liver Transpl. 2005 Nov;(11 Suppl 2):S30-4 [16237684] Environ Health Perspect. 2006 Apr;114(4):553-9 [16581545] JAMA. 2006 Jul 5;296(1):87-93 [16820551] Toxicol Pathol. 2006;34(6):795-801 [17162537] Toxicol Lett. 2001 Mar 31;120(1-3):317-21 [11323190] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Urban Environment and Human Environmental Health: Public Participation in Environmental Health Research. T2 - 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America AN - 40753386; 4778967 JF - 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America AU - Olden, K Y1 - 2007/11/11/ PY - 2007 DA - 2007 Nov 11 KW - Environmental health KW - Urban areas KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40753386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+North+America&rft.atitle=Urban+Environment+and+Human+Environmental+Health%3A+Public+Participation+in+Environmental+Health+Research.&rft.au=Olden%2C+K&rft.aulast=Olden&rft.aufirst=K&rft.date=2007-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+North+America&rft.issn=&rft_id=info:doi/ L2 - http://milwaukee.setac.org/pdf/2007_Abstract_Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk. AN - 68486505; 17971527 AB - Given the extended survival of patients diagnosed with cervical cancer, the large number of these women treated with radiotherapy, and the presence in this population of established cancer risk factors such as human papillomavirus (HPV) infection and cigarette smoking, it is important to clarify long-term trends in second cancer risk. Using data from 104,760 one-year survivors of cervical cancer reported to 13 population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States, we calculated standardized incidence ratios (SIRs) for second cancers overall and cancers at particular sites among women with cervical cancer, including cervical cancer patients who were treated or not treated with radiation, over more than 40 years of follow-up. Cox regression models were used to assess the time-varying association of radiotherapy with risk of second cancers and to assess the interaction of radiation treatment with age at diagnosis. All statistical tests were two-sided. Among 104,760 one-year survivors of cervical cancer, the risk of all second cancers taken together was increased to a statistically significant extent (n = 12,496; SIR = 1.30; 95% confidence interval [CI] = 1.28 to 1.33). Compared with the general population, in both radiotherapy (N = 52,613) and no-radiotherapy groups (N = 27,382), risks for HPV-related cancers (of the pharynx, genital sites, and rectum/anus) and smoking-related cancers (of the pharynx, trachea/bronchus/lung, pancreas, and urinary bladder) were elevated to a statistically significant extent. Cervical cancer patients treated with radiotherapy, but not those who did not receive radiotherapy, were at increased risk for all second cancers and cancers at heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites) beyond 40 years of follow-up compared with women in the general population. The association of radiotherapy with second cancer risk was modified by age at cervical cancer diagnosis for rectum/anus, genital sites, and urinary bladder, with higher hazard ratios for second cancer at younger ages of cervical cancer. After adjustment for competing mortality, the 40-year cumulative risk of any second cancer was higher among women diagnosed with cervical cancer before age 50 (22.2%; 95% CI = 21.5% to 22.8%) than among women diagnosed after age 50 (16.4%; 95% CI = 16.1% to 16.9%). Cervical cancer patients treated with radiotherapy are at increased risk of second cancers at sites in close proximity to the cervix beyond 40 years of follow-up. JF - Journal of the National Cancer Institute AU - Chaturvedi, Anil K AU - Engels, Eric A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Storm, Hans AU - Lynch, Charles F AU - Hall, Per AU - Langmark, Froydis AU - Pukkala, Eero AU - Kaijser, Magnus AU - Andersson, Michael AU - Fosså, Sophie D AU - Joensuu, Heikki AU - Boice, John D AU - Kleinerman, Ruth A AU - Travis, Lois B AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA. chaturva@mail.nih.gov Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1634 EP - 1643 VL - 99 IS - 21 KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Humans KW - Linear Models KW - SEER Program KW - Tumor Virus Infections -- epidemiology KW - Aged KW - Smoking -- epidemiology KW - Risk Assessment KW - Papillomavirus Infections -- epidemiology KW - Adult KW - Papillomavirus Infections -- complications KW - Smoking -- adverse effects KW - Radiotherapy -- adverse effects KW - Registries KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Middle Aged KW - Follow-Up Studies KW - United States -- epidemiology KW - Finland -- epidemiology KW - Scandinavian and Nordic Countries -- epidemiology KW - Female KW - Proportional Hazards Models KW - Tumor Virus Infections -- complications KW - Survivors -- statistics & numerical data KW - Neoplasms, Second Primary -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Neoplasms, Second Primary -- etiology KW - Uterine Cervical Neoplasms -- radiotherapy KW - Neoplasms, Second Primary -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68486505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+cancers+among+104%2C760+survivors+of+cervical+cancer%3A+evaluation+of+long-term+risk.&rft.au=Chaturvedi%2C+Anil+K%3BEngels%2C+Eric+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BStorm%2C+Hans%3BLynch%2C+Charles+F%3BHall%2C+Per%3BLangmark%2C+Froydis%3BPukkala%2C+Eero%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BFoss%C3%A5%2C+Sophie+D%3BJoensuu%2C+Heikki%3BBoice%2C+John+D%3BKleinerman%2C+Ruth+A%3BTravis%2C+Lois+B&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1634&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 2008 Apr 16;100(8):600; author reply 600-1 [18398096] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Chitosan Solution, a Novel Adjuvant/Depot for Subcutaneous Vaccination, Enhances Both Humoral and Cell-Mediated Immune Responses. T2 - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AN - 40739142; 4770405 JF - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AU - Greiner, John W AU - Rogers, Connie J AU - Hance, Kenneth W AU - Schlom, Jeffrey AU - Zaharoff, David A Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 KW - Vaccination KW - Chitosan KW - Adjuvants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40739142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.atitle=Chitosan+Solution%2C+a+Novel+Adjuvant%2FDepot+for+Subcutaneous+Vaccination%2C+Enhances+Both+Humoral+and+Cell-Mediated+Immune+Responses.&rft.au=Greiner%2C+John+W%3BRogers%2C+Connie+J%3BHance%2C+Kenneth+W%3BSchlom%2C+Jeffrey%3BZaharoff%2C+David+A&rft.aulast=Greiner&rft.aufirst=John&rft.date=2007-11-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/mvaf_2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prospective Study of Serum Vitamin D and Cancer Mortality in the United States AN - 20373976; 7743532 AB - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P sub(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality. JF - Journal of the National Cancer Institute AU - Freedman, DMichal AU - Looker, Anne C AU - Chang, Shih-Chen AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1594 EP - 1602 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - risk reduction KW - USA KW - Age KW - vitamins KW - survival KW - Nutrition KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Prospective+Study+of+Serum+Vitamin+D+and+Cancer+Mortality+in+the+United+States&rft.au=Freedman%2C+DMichal%3BLooker%2C+Anne+C%3BChang%2C+Shih-Chen%3BGraubard%2C+Barry+I&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; vitamins; survival; Nutrition; Ethnic groups; Cancer; USA ER - TY - JOUR T1 - Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity AN - 20371567; 7741610 AB - CONTEXT: The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population. OBJECTIVE: To estimate cause-specific excess deaths associated with underweight (BMI <18.5), overweight (BMI 25-<30), and obesity (BMI greater than or equal to 30). Design, Setting, and Participants Cause-specific relative risks of mortality from the National Health and Nutrition Examination Survey (NHANES) I, 1971-1975; II, 1976-1980; and III, 1988-1994, with mortality follow-up through 2000 (571 042 person-years of follow-up) were combined with data on BMI and other covariates from NHANES 1999-2002 with underlying cause of death information for 2.3 million adults 25 years and older from 2004 vital statistics data for the United States. MAIN OUTCOME MEASURES: Cause-specific excess deaths in 2004 by BMI levels for categories of cardiovascular disease (CVD), cancer, and all other causes (noncancer, non-CVD causes). RESULTS: Based on total follow-up, underweight was associated with significantly increased mortality from noncancer, non-CVD causes (23 455 excess deaths; 95% confidence interval [CI], 11 848 to 35 061) but not associated with cancer or CVD mortality. Overweight was associated with significantly decreased mortality from noncancer, non-CVD causes (-69 299 excess deaths; 95% CI, -100 702 to -37 897) but not associated with cancer or CVD mortality. Obesity was associated with significantly increased CVD mortality (112 159 excess deaths; 95% CI, 87 842 to 136 476) but not associated with cancer mortality or with noncancer, non-CVD mortality. In further analyses, overweight and obesity combined were associated with increased mortality from diabetes and kidney disease (61 248 excess deaths; 95% CI, 49 685 to 72 811) and decreased mortality from other noncancer, non-CVD causes (-105 572 excess deaths; 95% CI, -161 816 to -49 328). Obesity was associated with increased mortality from cancers considered obesity-related (13 839 excess deaths; 95% CI, 1920 to 25 758) but not associated with mortality from other cancers. Comparisons across surveys suggested a decrease in the association of obesity with CVD mortality over time. CONCLUSIONS: The BMI-mortality association varies by cause of death. These results help to clarify the associations of BMI with all-cause mortality. JF - JAMA: Journal of the American Medical Association AU - Flegal, Katherine M AU - Graubard, Barry I AU - Williamson, David F AU - Gail, Mitchell H AD - National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville (Dr Flegal) and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda (Drs Graubard and Gail), Maryland Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 2028 EP - 2037 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 17 SN - 0098-7484, 0098-7484 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Death KW - Statistics KW - Body mass KW - obesity KW - Health KW - Adults KW - Nutrition KW - Evaluation KW - diabetes mellitus KW - body mass KW - Cardiorespiratory KW - Diseases KW - vital statistics KW - Mortality KW - Obesity KW - Gerontology KW - Surveys KW - Kidneys KW - Cancer KW - Diabetes KW - USA KW - Analysis KW - Kidney KW - AMA KW - Cardiovascular diseases KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20371567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Cause-Specific+Excess+Deaths+Associated+With+Underweight%2C+Overweight%2C+and+Obesity&rft.au=Flegal%2C+Katherine+M%3BGraubard%2C+Barry+I%3BWilliamson%2C+David+F%3BGail%2C+Mitchell+H&rft.aulast=Flegal&rft.aufirst=Katherine&rft.date=2007-11-07&rft.volume=298&rft.issue=17&rft.spage=2028&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Death; Statistics; Body mass; Gerontology; Surveys; Health; Adults; Kidneys; Nutrition; Cancer; Diabetes; Evaluation; Analysis; AMA; Cardiorespiratory; Diseases; Mortality; diabetes mellitus; body mass; Kidney; obesity; Cardiovascular diseases; vital statistics; USA ER - TY - JOUR T1 - The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases. AN - 68453112; 17939684 AB - The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the protein phosphatase 2C (PP2C) family and controls cell cycle checkpoints in response to DNA damage. p38 MAPK and ATM were identified as physiological substrates of Wip1, and we previously reported a substrate motif that was defined using variants of the p38(180pT 182pY) diphosphorylated peptide, TDDEMpTGpYVAT. However, the substrate recognition motifs for Wip1 have not been fully defined as the sequences surrounding the targeted residues in ATM and p38 MAPK appear to be unrelated. Using a recombinant human Wip1 catalytic domain (rWip1), in this study we measured the kinetic parameters for variants of the ATM(1981pS) phosphopeptide, AFEEGpSQSTTI. We found that rWip1 dephosphorylates phosphoserine and phosphothreonine in the p(S/T)Q motif, which is an essential requirement for substrate recognition. In addition, acidic, hydrophobic, or aromatic amino acids surrounding the p(S/T)Q sequence have a positive influence, while basic amino acids have a negative influence on substrate dephosphorylation. The kinetic constants allow discrimination between true substrates and nonsubstrates of Wip1, and we identified several new putative substrates that include HDM2, SMC1A, ATR, and Wip1 itself. A three-dimensional molecular model of Wip1 with a bound substrate peptide and site-directed mutagenesis analyses suggested that the important residues for ATM(1981pS) substrate recognition are similar but not identical to those for the p38(180pT 182pY) substrate. Results from this study should be useful for predicting new physiological substrates that may be regulated by Wip1 and for developing selective anticancer drugs. JF - Biochemistry AU - Yamaguchi, Hiroshi AU - Durell, Stewart R AU - Chatterjee, Deb K AU - Anderson, Carl W AU - Appella, Ettore AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 12594 EP - 12603 VL - 46 IS - 44 SN - 0006-2960, 0006-2960 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Peptide Fragments KW - Recombinant Proteins KW - Tumor Suppressor Proteins KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - PPM1A protein, human KW - EC 3.1.3.16 KW - PPM1B protein, human KW - PPM1D protein, human KW - PPM1G protein, human KW - Phosphoprotein Phosphatases KW - Protein Phosphatase 2C KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Peptide Fragments -- chemistry KW - Amino Acid Motifs KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Substrate Specificity KW - Recombinant Proteins -- chemistry KW - Catalytic Domain -- physiology KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- chemistry KW - Phosphoprotein Phosphatases -- physiology KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Phosphoprotein Phosphatases -- chemistry KW - Phosphatidylinositol 3-Kinases -- chemistry KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68453112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+Wip1+phosphatase+PPM1D+dephosphorylates+SQ%2FTQ+motifs+in+checkpoint+substrates+phosphorylated+by+PI3K-like+kinases.&rft.au=Yamaguchi%2C+Hiroshi%3BDurell%2C+Stewart+R%3BChatterjee%2C+Deb+K%3BAnderson%2C+Carl+W%3BAppella%2C+Ettore&rft.aulast=Yamaguchi&rft.aufirst=Hiroshi&rft.date=2007-11-06&rft.volume=46&rft.issue=44&rft.spage=12594&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion AN - 20551814; 7745631 AB - Plasmodium falciparum invasion of human erythrocytes involves several parasite and erythrocyte receptors that enable parasite invasion by multiple redundant pathways. A key challenge to the development of effective vaccines that block parasite infection of erythrocytes is identifying the players in these pathways and determining their function. Invasion by the parasite clone, Dd2, requires sialic acid on the erythrocyte surface; Dd2/NM is a variant selected for its ability to invade neuraminidase-treated erythrocytes that lack sialic acid. The P. falciparum protein, reticulocyte homology 4 (PfRH4), is uniquely up-regulated in Dd2/NM compared with Dd2, suggesting that it may be a parasite receptor involved in invasion. The aim of the present study was to determine the role of PfRH4 in invasion of erythrocytes and to determine whether it is a target of antibody-mediated blockade and thus a vaccine candidate. We show that both native PfRH4 and a recombinant 30-kDa protein to a conserved region of PfRH4 (rRH4 sub(30)) bind strongly to neuraminidase-treated erythrocytes. rRH4 sub(30) blocks both the erythrocyte binding of the native PfRH4 and invasion of neuraminidase-treated erythrocytes by Dd2/NM. Taken together, these results indicate that PfRH4 is a parasite receptor involved in sialic acid-independent invasion of erythrocytes. Although antibodies to rRH4 sub(30) block binding of the native protein to erythrocytes, these antibodies failed to block invasion. These findings suggest that, although PfRH4 is required for invasion of neuraminidase-treated erythrocytes by Dd2/NM, it is inaccessible for antibody-mediated inhibition of the invasion process. JF - Proceedings of the National Academy of Sciences, USA AU - Gaur, Deepak AU - Singh, Sanjay AU - Singh, Subhash AU - Jiang, Lubin AU - Diouf, Ababacar AU - Miller, Louis H AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook III, 12735 Twinbrook Parkway, Bethesda, MD 20892-8132 Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 17789 EP - 17794 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 45 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Erythrocytes KW - Disease control KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Public health KW - Antibodies KW - Homology KW - Vaccines KW - Reticulocytes KW - Sialic acids KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Recombinant+Plasmodium+falciparum+reticulocyte+homology+protein+4+binds+to+erythrocytes+and+blocks+invasion&rft.au=Gaur%2C+Deepak%3BSingh%2C+Sanjay%3BSingh%2C+Subhash%3BJiang%2C+Lubin%3BDiouf%2C+Ababacar%3BMiller%2C+Louis+H&rft.aulast=Gaur&rft.aufirst=Deepak&rft.date=2007-11-06&rft.volume=104&rft.issue=45&rft.spage=17789&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Human diseases; Erythrocytes; Disease control; Malaria; Vaccines; Public health; Homology; Infection; Reticulocytes; Sialic acids; Plasmodium falciparum ER - TY - JOUR T1 - Neural Substrates of Intermanual Transfer of a Newly Acquired Motor Skill AN - 20421354; 7768391 AB - In healthy humans, the two cerebral hemispheres show functional specialization to a degree unmatched in other animals, and such strong hemispheric specialization contributes to unimanual skill acquisition. When most humans learn a new motor skill with one hand, this process results in performance improvements in the opposite hand as well. Despite the obvious adaptive advantage of such intermanual transfer, there is no direct evidence identifying the neural substrates of this form of skill acquisition. Here, we used functional magnetic resonance imaging (fMRI) to study brain regions activated during intermanual transfer of a learned sequence of finger movements. First, we found that the supplementary motor area (SMA) has more activity when a skill has transferred well than when it has transferred poorly. Second, we found that fMRI activity in the ventrolateral posterior thalamic nucleus correlated with successful future intermanual transfer, whereas activity in the ventrolateral anterior thalamic nucleus correlated with past intermanual transfer. Third, we found that repetitive transcranial magnetic stimulation applied over the SMA blocked intermanual transfer without affecting skill acquisition. These findings provide direct evidence for an SMA-based mechanism that supports intermanual transfer of motor-skill learning. JF - Current Biology AU - Perez, MA AU - Tanaka, S AU - Wise, S P AU - Sadato, N AU - Tanabe, H C AU - Willingham, D T AU - Cohen, L G AD - Human Cortical Physiology Section and Stroke, Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1430, USA, cohenl@ninds.nih.gov Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 1896 EP - 1902 VL - 17 IS - 21 SN - 0960-9822, 0960-9822 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Hands KW - Brain mapping KW - Hemispheric laterality KW - supplementary motor area KW - Motor skills KW - Functional magnetic resonance imaging KW - Cerebral hemispheres KW - Brain KW - Hand KW - Specialization KW - Health KW - Thalamus KW - Finger KW - Fingers KW - Transfer learning KW - Transcranial magnetic stimulation KW - Scanning KW - Motor performance KW - Transfer of learning KW - Movement sequence KW - Stimuli KW - Motor skill learning KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 080:Motor Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20421354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Neural+Substrates+of+Intermanual+Transfer+of+a+Newly+Acquired+Motor+Skill&rft.au=Perez%2C+MA%3BTanaka%2C+S%3BWise%2C+S+P%3BSadato%2C+N%3BTanabe%2C+H+C%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Perez&rft.aufirst=MA&rft.date=2007-11-06&rft.volume=17&rft.issue=21&rft.spage=1896&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2007.09.058 LA - English DB - Physical Education Index N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hands; Fingers; Scanning; Motor skills; Motor performance; Movement sequence; Transfer of learning; Brain; Stimuli; Health; Brain mapping; supplementary motor area; Hemispheric laterality; Transcranial magnetic stimulation; Transfer learning; Cerebral hemispheres; Functional magnetic resonance imaging; Specialization; Hand; Motor skill learning; Thalamus; Finger DO - http://dx.doi.org/10.1016/j.cub.2007.09.058 ER - TY - CPAPER T1 - Disruption of a Putative ABC Transporter in Plasmodium falciparum Alters Parasite Growth and Responses to Antimalarial Drugs T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40775387; 4777335 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Raj, Dipak K Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Parasites KW - Drugs KW - ABC transporter KW - Growth KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Disruption+of+a+Putative+ABC+Transporter+in+Plasmodium+falciparum+Alters+Parasite+Growth+and+Responses+to+Antimalarial+Drugs&rft.au=Raj%2C+Dipak+K&rft.aulast=Raj&rft.aufirst=Dipak&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Nitric Oxide Production in Intraerythrocytic Stages of the Malaria Parasite Plasmodium falciparum T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40767814; 4777268 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Ostera, Graciela R AU - Tokumasu, Fuyuki AU - Dvorak, James A Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Parasites KW - Malaria KW - Nitric oxide KW - Public health KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Endogenous+Nitric+Oxide+Production+in+Intraerythrocytic+Stages+of+the+Malaria+Parasite+Plasmodium+falciparum&rft.au=Ostera%2C+Graciela+R%3BTokumasu%2C+Fuyuki%3BDvorak%2C+James+A&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lutzomyia longipalpis Salivary Recombinant Proteins Recognized by Human, Dog and Fox Antibodies T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40766834; 4777177 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gomes, Regis B AU - Collin, Nicolas AU - Teixeira, Clarissa AU - Jochim, Ryan AU - Elnaiem, Dia-eldin AU - Volf, Peter AU - Costa, Carlos AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Antibodies KW - Recombinants KW - Lutzomyia longipalpis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Lutzomyia+longipalpis+Salivary+Recombinant+Proteins+Recognized+by+Human%2C+Dog+and+Fox+Antibodies&rft.au=Gomes%2C+Regis+B%3BCollin%2C+Nicolas%3BTeixeira%2C+Clarissa%3BJochim%2C+Ryan%3BElnaiem%2C+Dia-eldin%3BVolf%2C+Peter%3BCosta%2C+Carlos%3BValenzuela%2C+Jesus+G&rft.aulast=Gomes&rft.aufirst=Regis&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lights, Camera, Action: A Method to Study Male Anopheles gambiae Mating Behavior in the Field T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40766258; 4777360 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Manoukis, Nicholas C AU - Diabate, Abdoulaye AU - Dao, Adama AU - Tokumasu, Fuyuki AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cameras KW - Mating behavior KW - Light effects KW - Aquatic insects KW - Reproductive behavior KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Lights%2C+Camera%2C+Action%3A+A+Method+to+Study+Male+Anopheles+gambiae+Mating+Behavior+in+the+Field&rft.au=Manoukis%2C+Nicholas+C%3BDiabate%2C+Abdoulaye%3BDao%2C+Adama%3BTokumasu%2C+Fuyuki%3BLehmann%2C+Tovi&rft.aulast=Manoukis&rft.aufirst=Nicholas&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Decision Tree Model for Estimating the Cost-Effectiveness of Rectal Artesunate Treatment for Severe Childhood Malaria at the Community Level T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40765371; 4777311 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Tozan, Yesim AU - Breman, Joel G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cost-benefit analysis KW - Children KW - Malaria KW - Artesunate KW - Models KW - Rectum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Decision+Tree+Model+for+Estimating+the+Cost-Effectiveness+of+Rectal+Artesunate+Treatment+for+Severe+Childhood+Malaria+at+the+Community+Level&rft.au=Tozan%2C+Yesim%3BBreman%2C+Joel+G&rft.aulast=Tozan&rft.aufirst=Yesim&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Two-Stage Model of Malaria Transmission and its Impact on the Spread of Resistance T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40765078; 4777310 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Smith, David L AU - Boni, Maciej AU - Klein, Eili AU - Laxminarayan, Ramanan Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Malaria KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Two-Stage+Model+of+Malaria+Transmission+and+its+Impact+on+the+Spread+of+Resistance&rft.au=Smith%2C+David+L%3BBoni%2C+Maciej%3BKlein%2C+Eili%3BLaxminarayan%2C+Ramanan&rft.aulast=Smith&rft.aufirst=David&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abundance of Immunomodulatory Proteins Revealed by Analysis of the Excretory-Secretory (E/S) Proteome of Brugia malayi T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764227; 4777437 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Bennuru, Sasisekhar AU - Semnani, Roshanak AU - Ribeiro, Jose M.C. AU - Meng, Zhaojing AU - Veenstra, Timothy D AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Abundance KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Abundance+of+Immunomodulatory+Proteins+Revealed+by+Analysis+of+the+Excretory-Secretory+%28E%2FS%29+Proteome+of+Brugia+malayi&rft.au=Bennuru%2C+Sasisekhar%3BSemnani%2C+Roshanak%3BRibeiro%2C+Jose+M.C.%3BMeng%2C+Zhaojing%3BVeenstra%2C+Timothy+D%3BNutman%2C+Thomas+B&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of a Highly Sensitive Human Fecal Biomarker (10@@u-10@) IN = 10 ml Contaminated Drinking Water Samples using Immunomagnetic Separation T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764200; 4777515 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Sevilleja, Jesus Emmanuel A AU - Copeland, Curtis C AU - Guerrant, Richard L Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Bioindicators KW - Drinking water KW - Immunomagnetic separation KW - Biomarkers KW - Water pollution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Detection+of+a+Highly+Sensitive+Human+Fecal+Biomarker+%2810%40%40u-10%40%29+IN+%3D+10+ml+Contaminated+Drinking+Water+Samples+using+Immunomagnetic+Separation&rft.au=Sevilleja%2C+Jesus+Emmanuel+A%3BCopeland%2C+Curtis+C%3BGuerrant%2C+Richard+L&rft.aulast=Sevilleja&rft.aufirst=Jesus+Emmanuel&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Platform for Generating Conjugated Malarial Vaccines to Pseudomonas aeruginosa Exoprotein A T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764059; 4777349 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Qian, Feng AU - Reiter, Karine AU - Zhang, Yanling AU - Shimp Jr, Richard L AU - Nguyen, Vu AU - Lebowitz, Jacob AU - Lambert, Lynn AU - Mullen, Gregory E AU - Martin, Laura B AU - Miller, Louis H AU - Narum, David L Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Disease control KW - Pseudomonas aeruginosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Platform+for+Generating+Conjugated+Malarial+Vaccines+to+Pseudomonas+aeruginosa+Exoprotein+A&rft.au=Qian%2C+Feng%3BReiter%2C+Karine%3BZhang%2C+Yanling%3BShimp+Jr%2C+Richard+L%3BNguyen%2C+Vu%3BLebowitz%2C+Jacob%3BLambert%2C+Lynn%3BMullen%2C+Gregory+E%3BMartin%2C+Laura+B%3BMiller%2C+Louis+H%3BNarum%2C+David+L&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of CpG on Stability of BSAM-1/Alhydrogel Formulation T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40763713; 4777346 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Zhu, Daming AU - Gebregeorgis, Elizabeth M AU - McClellan, Holly A AU - Huang, Shuhui AU - Miller, Louis H AU - Martin, Laura B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Effect+of+CpG+on+Stability+of+BSAM-1%2FAlhydrogel+Formulation&rft.au=Zhu%2C+Daming%3BGebregeorgis%2C+Elizabeth+M%3BMcClellan%2C+Holly+A%3BHuang%2C+Shuhui%3BMiller%2C+Louis+H%3BMartin%2C+Laura+B&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coexistent Filarial Infections Downregulate Antigen-Specific Th1 and Th17 Responses in Latent Tuberculosis: Association with Enhanced Expression of CTLA-4 and PD-1 T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40762721; 4777438 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Babu, Subash AU - Jayantasri, V AU - Rukmani, S AU - Kumaran, Paul AU - Gopi, P G AU - Sadacharam, K AU - Kumaraswami, V AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Tuberculosis KW - CTLA-4 protein KW - Lymphocytes T KW - PD-1 protein KW - Helper cells KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Coexistent+Filarial+Infections+Downregulate+Antigen-Specific+Th1+and+Th17+Responses+in+Latent+Tuberculosis%3A+Association+with+Enhanced+Expression+of+CTLA-4+and+PD-1&rft.au=Babu%2C+Subash%3BJayantasri%2C+V%3BRukmani%2C+S%3BKumaran%2C+Paul%3BGopi%2C+P+G%3BSadacharam%2C+K%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brugia malayi Microfilariae Inhibit IFNg and TNF-a in Response to Mycobacterium tuberculosis Infection in a Murine Coinfection Model T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40762618; 4777439 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Talaat, Kawsar R AU - Feng, Carl G AU - Scanga, Charles A AU - Mentink-Kane, Margaret M AU - White, Sandy AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Tuberculosis KW - Animal models KW - Tumor necrosis factor-a KW - Mycobacterium tuberculosis KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Brugia+malayi+Microfilariae+Inhibit+IFNg+and+TNF-a+in+Response+to+Mycobacterium+tuberculosis+Infection+in+a+Murine+Coinfection+Model&rft.au=Talaat%2C+Kawsar+R%3BFeng%2C+Carl+G%3BScanga%2C+Charles+A%3BMentink-Kane%2C+Margaret+M%3BWhite%2C+Sandy%3BNutman%2C+Thomas+B&rft.aulast=Talaat&rft.aufirst=Kawsar&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphism in the Gene Encoding Gambicin and Plasmodium falciparum Infection Susceptibility in Anopheles gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40761412; 4777630 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gonzalez-Cerdas, Rodrigo AU - Riehle, Michelle M AU - Vernick, Kenneth D AU - Hume, Jen AU - Ribeiro, Jose AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Gene polymorphism KW - Parasites KW - Aquatic insects KW - Pest control KW - Plasmodium falciparum KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Polymorphism+in+the+Gene+Encoding+Gambicin+and+Plasmodium+falciparum+Infection+Susceptibility+in+Anopheles+gambiae&rft.au=Gonzalez-Cerdas%2C+Rodrigo%3BRiehle%2C+Michelle+M%3BVernick%2C+Kenneth+D%3BHume%2C+Jen%3BRibeiro%2C+Jose%3BLehmann%2C+Tovi&rft.aulast=Gonzalez-Cerdas&rft.aufirst=Rodrigo&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Plasmodium falciparum Receptor BAEBL for Binding to Erythrocyte Ligand Glycophorin C T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760933; 4777269 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Jiang, Lubin AU - Duriseti, Sai AU - Sun, Peter AU - Miller, Louis H Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Erythrocytes KW - Glycophorin C KW - Parasites KW - Ligands KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Basis+of+Plasmodium+falciparum+Receptor+BAEBL+for+Binding+to+Erythrocyte+Ligand+Glycophorin+C&rft.au=Jiang%2C+Lubin%3BDuriseti%2C+Sai%3BSun%2C+Peter%3BMiller%2C+Louis+H&rft.aulast=Jiang&rft.aufirst=Lubin&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Swarm Segregation is the Main Mechanism that Prevents Mating between Sympatric Molecular Forms of Anopheles gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760821; 4777767 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Diabate, Abdoulaye AU - Dao, Adama AU - Yaro, Alpha S AU - Alpha, Adamou AU - Traore, S Cheick AU - Gonzalez, Rodrigo AU - Gwadz, Bob AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Sympatric populations KW - Mating KW - Swarms KW - Aquatic insects KW - Reproductive behavior KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Swarm+Segregation+is+the+Main+Mechanism+that+Prevents+Mating+between+Sympatric+Molecular+Forms+of+Anopheles+gambiae&rft.au=Diabate%2C+Abdoulaye%3BDao%2C+Adama%3BYaro%2C+Alpha+S%3BAlpha%2C+Adamou%3BTraore%2C+S+Cheick%3BGonzalez%2C+Rodrigo%3BGwadz%2C+Bob%3BLehmann%2C+Tovi&rft.aulast=Diabate&rft.aufirst=Abdoulaye&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Specificity and Cross Reactivity in Delayed-Type-Hypersensitivity Reactions to Bites of Sand Flies and Implication for Protection Against Leishmania Infection T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760391; 4777182 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Elnaiem, Dia-Eldin A AU - Oliveira, Luiz F AU - Gomes, Regis B AU - Toxeira, Clarissa AU - Subrahmanyam, Sreenath AU - Kamhawi, Shaden AU - Lawyer, Phillip G AU - Ward, Jerrold M AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Bites KW - Sand KW - Specificity KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Basis+of+Specificity+and+Cross+Reactivity+in+Delayed-Type-Hypersensitivity+Reactions+to+Bites+of+Sand+Flies+and+Implication+for+Protection+Against+Leishmania+Infection&rft.au=Elnaiem%2C+Dia-Eldin+A%3BOliveira%2C+Luiz+F%3BGomes%2C+Regis+B%3BToxeira%2C+Clarissa%3BSubrahmanyam%2C+Sreenath%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip+G%3BWard%2C+Jerrold+M%3BValenzuela%2C+Jesus+G&rft.aulast=Elnaiem&rft.aufirst=Dia-Eldin&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Eosinophils are not Required for Dec-Mediated Clearance of Microfilaremia T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760346; 4777176 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Klion, Amy D AU - Talaat, Kawsar AU - White, Sandy AU - Rosenberg, Helene AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Leukocytes (eosinophilic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Eosinophils+are+not+Required+for+Dec-Mediated+Clearance+of+Microfilaremia&rft.au=Klion%2C+Amy+D%3BTalaat%2C+Kawsar%3BWhite%2C+Sandy%3BRosenberg%2C+Helene%3BNutman%2C+Thomas+B&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anopheles gambiae Gut Flora Dinamics and Microarray Analysis of Gut Gene Expression in Response to Bacteria T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760125; 4777777 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Molina-Cruz, Alvaro AU - Leszczynski, Sara AU - Gupta, Lalita AU - Kumar, Sanjeev AU - DeJong, Randall AU - Ndikuyeze, Georges AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Flora KW - Digestive tract KW - Gene expression KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Anopheles+gambiae+Gut+Flora+Dinamics+and+Microarray+Analysis+of+Gut+Gene+Expression+in+Response+to+Bacteria&rft.au=Molina-Cruz%2C+Alvaro%3BLeszczynski%2C+Sara%3BGupta%2C+Lalita%3BKumar%2C+Sanjeev%3BDeJong%2C+Randall%3BNdikuyeze%2C+Georges%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mononeme: A New Secretory Organelle in P. falciparum Merozoites Identified by Localization of Rhomboid-1 Protease T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759472; 4777817 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Singh, Subhash AU - Plassmeyer, Matthew AU - Gaur, Deepak AU - Miller, Louis Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Proteinase KW - Organelles KW - Merozoites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Mononeme%3A+A+New+Secretory+Organelle+in+P.+falciparum+Merozoites+Identified+by+Localization+of+Rhomboid-1+Protease&rft.au=Singh%2C+Subhash%3BPlassmeyer%2C+Matthew%3BGaur%2C+Deepak%3BMiller%2C+Louis&rft.aulast=Singh&rft.aufirst=Subhash&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={15F7A93A -D47A-42C5-825A-0520A3323FD2}&AKey={F80697F6-E207-4950-99FC-3AE41F9B 4B10} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunity to Saliva at the Tick-Host Interface: Identification of Ixodes scapularis Salivary Proteins Eliciting a Cellular Immune Response T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759409; 4777800 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Anderson, Jennifer M AU - Miller, Nathan J AU - Mather, Thomas N AU - Ward, Jerrold M AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Immune response KW - Immunity KW - Saliva KW - Defense mechanisms KW - Ixodes scapularis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Immunity+to+Saliva+at+the+Tick-Host+Interface%3A+Identification+of+Ixodes+scapularis+Salivary+Proteins+Eliciting+a+Cellular+Immune+Response&rft.au=Anderson%2C+Jennifer+M%3BMiller%2C+Nathan+J%3BMather%2C+Thomas+N%3BWard%2C+Jerrold+M%3BValenzuela%2C+Jesus+G&rft.aulast=Anderson&rft.aufirst=Jennifer&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Identification of Wolbachia from the Filarial Nematode Mansonella perstans T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759042; 4777825 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Kubofcik, Joseph AU - Keiser, Paul AU - Coulibaly, Yaya AU - Klion, Amy D AU - Traore', Sekou AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Nematodes KW - Wolbachia KW - Nematoda KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Identification+of+Wolbachia+from+the+Filarial+Nematode+Mansonella+perstans&rft.au=Kubofcik%2C+Joseph%3BKeiser%2C+Paul%3BCoulibaly%2C+Yaya%3BKlion%2C+Amy+D%3BTraore%27%2C+Sekou%3BNutman%2C+Thomas+B&rft.aulast=Kubofcik&rft.aufirst=Joseph&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={15F7A93A -D47A-42C5-825A-0520A3323FD2}&AKey={F80697F6-E207-4950-99FC-3AE41F9B 4B10} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microfilaria Positivity Modulates the Expression of FCER1-A on Monocytes in Filaria-Infected Patients T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40757661; 4777699 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Steel, Cathy AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Monocytes KW - Filarioidea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Microfilaria+Positivity+Modulates+the+Expression+of+FCER1-A+on+Monocytes+in+Filaria-Infected+Patients&rft.au=Steel%2C+Cathy%3BNutman%2C+Thomas+B&rft.aulast=Steel&rft.aufirst=Cathy&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Responsive Serine Protease from Anopheles gambiae Promotes Plasmodium falciparum Development T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40757278; 4777639 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Rodrigues, Janneth AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Serine proteinase KW - Parasites KW - Aquatic insects KW - Plasmodium falciparum KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Immune+Responsive+Serine+Protease+from+Anopheles+gambiae+Promotes+Plasmodium+falciparum+Development&rft.au=Rodrigues%2C+Janneth%3BBarillas-Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A DNA Vaccine Encoding a Sand Fly Salivary Yellow Related Protein (LJM11) Confers Protection Against Challenge with L. major in the Presence of L. longipalpis Salivary Gland Homogenate T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40756009; 4777793 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Oliveira, Luiz F AU - Gomes, 5Regis B. AU - Kamhawi, Shaden AU - Teixeira, Clarissa AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Sand KW - DNA vaccines KW - Salivary gland KW - Glands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+DNA+Vaccine+Encoding+a+Sand+Fly+Salivary+Yellow+Related+Protein+%28LJM11%29+Confers+Protection+Against+Challenge+with+L.+major+in+the+Presence+of+L.+longipalpis+Salivary+Gland+Homogenate&rft.au=Oliveira%2C+Luiz+F%3BGomes%2C+5Regis+B.%3BKamhawi%2C+Shaden%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Oliveira&rft.aufirst=Luiz&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Secreted Anopheles Midgut Peroxidase Regulates Plasmodium falciparum Development T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40754796; 4777691 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Kumar, Sanjeev AU - Gupta, Lalita AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Midgut KW - Peroxidase KW - Parasites KW - Aquatic insects KW - Anopheles KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Secreted+Anopheles+Midgut+Peroxidase+Regulates+Plasmodium+falciparum+Development&rft.au=Kumar%2C+Sanjeev%3BGupta%2C+Lalita%3BBarillas-Mury%2C+Carolina&rft.aulast=Kumar&rft.aufirst=Sanjeev&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Animal Immunogenicity Studies of a Blood-Stage Malaria Vaccine Based on a Combination of AMA1 and MSP1@@d42@ T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40753612; 4776852 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Martin, Laura B AU - Long, Carole A AU - Zhou, Hong AU - Medina, Sarimar AU - Newland, Joseph AU - Moretz, Samuel E AU - Lambert, Lynn E AU - Mullen, Gregory E AU - Saul, Allan AU - Miller, Louis H Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Malaria KW - Immunogenicity KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40753612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Animal+Immunogenicity+Studies+of+a+Blood-Stage+Malaria+Vaccine+Based+on+a+Combination+of+AMA1+and+MSP1%40%40d42%40&rft.au=Martin%2C+Laura+B%3BLong%2C+Carole+A%3BZhou%2C+Hong%3BMedina%2C+Sarimar%3BNewland%2C+Joseph%3BMoretz%2C+Samuel+E%3BLambert%2C+Lynn+E%3BMullen%2C+Gregory+E%3BSaul%2C+Allan%3BMiller%2C+Louis+H&rft.aulast=Martin&rft.aufirst=Laura&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Towards a Vaccine Against Canine Visceral Leishmaniasis Based on Vector Salivary Antigens T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40751315; 4777728 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Collin, Nicolas AU - Kamhawi, Shaden AU - Gomes, Regis B AU - Teixeira, Clarissa AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Visceral leishmaniasis KW - Antigens KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40751315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Towards+a+Vaccine+Against+Canine+Visceral+Leishmaniasis+Based+on+Vector+Salivary+Antigens&rft.au=Collin%2C+Nicolas%3BKamhawi%2C+Shaden%3BGomes%2C+Regis+B%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Collin&rft.aufirst=Nicolas&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Rapid and Specific Immunodiagnostic Assay for Strongyloides Infection using a Luciferase Immunoprecipitation System T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40750495; 4776937 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Ramanathan, Roshan AU - Burbelo, Peter B AU - Iadarola, Michael J AU - Neva, Franklin A AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Immunoprecipitation KW - Strongyloides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40750495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Development+of+a+Rapid+and+Specific+Immunodiagnostic+Assay+for+Strongyloides+Infection+using+a+Luciferase+Immunoprecipitation+System&rft.au=Ramanathan%2C+Roshan%3BBurbelo%2C+Peter+B%3BIadarola%2C+Michael+J%3BNeva%2C+Franklin+A%3BNutman%2C+Thomas+B&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stat Pathway Limits Plasmodium Infection in An. gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749346; 4777037 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Barillas-Mury, Carolina AU - Gupta, Lalita AU - Molina-Cruz, Alvaro AU - Kumar, Sanjeev Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=The+Stat+Pathway+Limits+Plasmodium+Infection+in+An.+gambiae&rft.au=Barillas-Mury%2C+Carolina%3BGupta%2C+Lalita%3BMolina-Cruz%2C+Alvaro%3BKumar%2C+Sanjeev&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anopheles Gambiae Stat Pathway Participates in Mosquito Immunity T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749163; 4776846 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gupta, Lalita AU - Kumar, Sanjeev Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Immunity KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Anopheles+Gambiae+Stat+Pathway+Participates+in+Mosquito+Immunity&rft.au=Gupta%2C+Lalita%3BKumar%2C+Sanjeev&rft.aulast=Gupta&rft.aufirst=Lalita&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Early Inflammatory Response Expression in Response to Phlebotomus duboscqi Bites T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749038; 4776874 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Teixeira, Clarissa R AU - Kamhawi, Shaden AU - Gomes, Regis B AU - Oliveira, Luiz F AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Bites KW - Inflammation KW - Phlebotomus duboscqi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Evaluation+of+Early+Inflammatory+Response+Expression+in+Response+to+Phlebotomus+duboscqi+Bites&rft.au=Teixeira%2C+Clarissa+R%3BKamhawi%2C+Shaden%3BGomes%2C+Regis+B%3BOliveira%2C+Luiz+F%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Teixeira&rft.aufirst=Clarissa&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of Bloodstage Malaria Vaccines MSP1@@d42@-C1/Alhydrogel with and without the Addition of CPG 7909 in Us Adults T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748938; 4777007 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Martin, Laura B AU - Shaffer, Donna AU - Ellis, Ruth D AU - Long, Carole A AU - Miura, Kazutoyo AU - Narum, David L AU - Zhu, Daming AU - Mullen, Gregory E AU - Mahanty, Siddhartha AU - Malkin, Elissa AU - Miller, Louis H AU - Saul, Allan AU - Durbin, Anna P Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Malaria KW - Immunogenicity KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+Bloodstage+Malaria+Vaccines+MSP1%40%40d42%40-C1%2FAlhydrogel+with+and+without+the+Addition+of+CPG+7909+in+Us+Adults&rft.au=Martin%2C+Laura+B%3BShaffer%2C+Donna%3BEllis%2C+Ruth+D%3BLong%2C+Carole+A%3BMiura%2C+Kazutoyo%3BNarum%2C+David+L%3BZhu%2C+Daming%3BMullen%2C+Gregory+E%3BMahanty%2C+Siddhartha%3BMalkin%2C+Elissa%3BMiller%2C+Louis+H%3BSaul%2C+Allan%3BDurbin%2C+Anna+P&rft.aulast=Martin&rft.aufirst=Laura&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Antigenic Chimeric St. Louis Encephalitis Virus/Dengue Virus Type 4 Recombinant Viruses in Mice and Monkeys T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748414; 4776926 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Blaney, Joseph AU - Wlazlo, Anthony AU - Speicher, James AU - Sathe, Neeraj AU - Hanson, Christopher AU - Murphy, Brian AU - Whitehead, Stephen AU - Pletnev, Alexander Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Mice KW - Dengue KW - Viruses KW - Encephalitis KW - Recombinants KW - Dengue virus type 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Characterization+of+Antigenic+Chimeric+St.+Louis+Encephalitis+Virus%2FDengue+Virus+Type+4+Recombinant+Viruses+in+Mice+and+Monkeys&rft.au=Blaney%2C+Joseph%3BWlazlo%2C+Anthony%3BSpeicher%2C+James%3BSathe%2C+Neeraj%3BHanson%2C+Christopher%3BMurphy%2C+Brian%3BWhitehead%2C+Stephen%3BPletnev%2C+Alexander&rft.aulast=Blaney&rft.aufirst=Joseph&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Markers of the Pathogenesis of Cerebral Malaria in the Murine Malaria Plasmodium berghei T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748178; 4776774 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Oakley, Miranda AU - Faucette, Laurence AU - Majam, Victoria AU - Zheng, Hong AU - Mahajan, Babita AU - Erexson, Cindy AU - Ward, Jerrold AU - McCutchan, Thomas AU - Kumar, Sanjai Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Malaria KW - Public health KW - Plasmodium berghei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Markers+of+the+Pathogenesis+of+Cerebral+Malaria+in+the+Murine+Malaria+Plasmodium+berghei&rft.au=Oakley%2C+Miranda%3BFaucette%2C+Laurence%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BMahajan%2C+Babita%3BErexson%2C+Cindy%3BWard%2C+Jerrold%3BMcCutchan%2C+Thomas%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purified IgGs from Unvaccinated Malians Interfere with the Biological Activity of Apical Membrane Antigen 1-Specific IgGs as Judged by the in Vitro Growth Inhibition Assay T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40747354; 4776823 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Miura, Kazutoyo AU - Zhou, Hong AU - Mullen, Gregory AU - Moretz, Samuel AU - Diouf, Ababacar AU - Diemert, David AU - Dicko, Alassane AU - Miller, Louis AU - Doumbo, Ogobara AU - Long, Carole Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Membranes KW - Immunoglobulin G KW - Antigens KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40747354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Purified+IgGs+from+Unvaccinated+Malians+Interfere+with+the+Biological+Activity+of+Apical+Membrane+Antigen+1-Specific+IgGs+as+Judged+by+the+in+Vitro+Growth+Inhibition+Assay&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BMullen%2C+Gregory%3BMoretz%2C+Samuel%3BDiouf%2C+Ababacar%3BDiemert%2C+David%3BDicko%2C+Alassane%3BMiller%2C+Louis%3BDoumbo%2C+Ogobara%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dichlorodiphenyltrichloroethane (DDT) for Indoor Residual Spraying in Africa: How can it be Used for Malaria Control? T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40746751; 4777018 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Tozan, Yesim AU - Sadasivaiah, Shobha AU - Breman, Joel G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Africa KW - Malaria KW - Insecticides KW - DDT KW - Spraying KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40746751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Dichlorodiphenyltrichloroethane+%28DDT%29+for+Indoor+Residual+Spraying+in+Africa%3A+How+can+it+be+Used+for+Malaria+Control%3F&rft.au=Tozan%2C+Yesim%3BSadasivaiah%2C+Shobha%3BBreman%2C+Joel+G&rft.aulast=Tozan&rft.aufirst=Yesim&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Plasmodium falciparum in Culex Mosquitoes T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40746089; 4777020 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Hume, Jen AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Aquatic insects KW - Parasites KW - Plasmodium falciparum KW - Culex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40746089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Development+of+Plasmodium+falciparum+in+Culex+Mosquitoes&rft.au=Hume%2C+Jen%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Potential Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells T2 - 9th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT 9) AN - 40733184; 4770728 JF - 9th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT 9) AU - Inkson, Colette A AU - Bi, Yanming AU - Kuznetsov, Sergei A AU - Young, Marian F Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cell proliferation KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40733184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Conference+on+the+Chemistry+and+Biology+of+Mineralized+Tissues+%28ICCBMT+9%29&rft.atitle=The+Potential+Interaction+of+Biglycan+and+WISP-1+in+Controlling+Differentiation+and+Proliferation+of+Osteogenic+Cells&rft.au=Inkson%2C+Colette+A%3BBi%2C+Yanming%3BKuznetsov%2C+Sergei+A%3BYoung%2C+Marian+F&rft.aulast=Inkson&rft.aufirst=Colette&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Conference+on+the+Chemistry+and+Biology+of+Mineralized+Tissues+%28ICCBMT+9%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iccbmt.org/9th%20ICCBMT%20-%20Final%20Program%20for%20websi te.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Personality Disorder Severity and Mental Disability: Results from the National Epidemiologic Survey on Alcohol and Related Conditions T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40781104; 4784076 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pulay, Attila J AU - Dawson, Deborah A AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Disabilities KW - Alcohols KW - Personality KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Personality+Disorder+Severity+and+Mental+Disability%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Supplements Labels Information for Consumers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771653; 4781380 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Goshorn, Jeanne C AU - Chang, H Florence AU - Moore, Dorothy R AU - Sun, Ying AU - Hudson, Vera H AU - Hazard, George F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dietary supplements KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Dietary+Supplements+Labels+Information+for+Consumers&rft.au=Goshorn%2C+Jeanne+C%3BChang%2C+H+Florence%3BMoore%2C+Dorothy+R%3BSun%2C+Ying%3BHudson%2C+Vera+H%3BHazard%2C+George+F&rft.aulast=Goshorn&rft.aufirst=Jeanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Model for Policy Analysis and Science-Guided Advocacy for Community Health Improvement T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40770027; 4780354 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hammond, Camille AU - McLean, Barbara Gill AU - Cornelius, Llewellyn J AU - Baquet, Claudia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Models KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Model+for+Policy+Analysis+and+Science-Guided+Advocacy+for+Community+Health+Improvement&rft.au=Hammond%2C+Camille%3BMcLean%2C+Barbara+Gill%3BCornelius%2C+Llewellyn+J%3BBaquet%2C+Claudia&rft.aulast=Hammond&rft.aufirst=Camille&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Qualitative Evaluation of the Assessment of Cancer Screening and Follow-Up (ACIC-Ca) Tool: Findings from Cancer Collaborative Participants in the Pursuit of Quality Improvement T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769873; 4780308 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ousley, Anita AU - Swarz, Jeff A AU - Bongiovanni, Annette AU - Sheahan, Daniel AU - Taplin, Stephen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Qualitative+Evaluation+of+the+Assessment+of+Cancer+Screening+and+Follow-Up+%28ACIC-Ca%29+Tool%3A+Findings+from+Cancer+Collaborative+Participants+in+the+Pursuit+of+Quality+Improvement&rft.au=Ousley%2C+Anita%3BSwarz%2C+Jeff+A%3BBongiovanni%2C+Annette%3BSheahan%2C+Daniel%3BTaplin%2C+Stephen&rft.aulast=Ousley&rft.aufirst=Anita&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Disaster Information Management Research Center at the National Library of Medicine: Update for Public Health Workers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769851; 4780268 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Phillips, Steven J AU - Love, Cynthia B AU - Arnesen, Stacey J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=New+Disaster+Information+Management+Research+Center+at+the+National+Library+of+Medicine%3A+Update+for+Public+Health+Workers&rft.au=Phillips%2C+Steven+J%3BLove%2C+Cynthia+B%3BArnesen%2C+Stacey+J&rft.aulast=Phillips&rft.aufirst=Steven&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Systematic Approach for Evaluating Health Related Programs: Adaptation for Community-Based Participatory Research and Clinical Application to Reduce Cancer Health Disparities T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768439; 4780259 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Taylor, Emmanuel A AU - Chu, Kenneth C AU - Newes-Adeyi, Gabriella M AU - Young, Paul A AU - Greene, Amanda Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Community involvement KW - Adaptations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Systematic+Approach+for+Evaluating+Health+Related+Programs%3A+Adaptation+for+Community-Based+Participatory+Research+and+Clinical+Application+to+Reduce+Cancer+Health+Disparities&rft.au=Taylor%2C+Emmanuel+A%3BChu%2C+Kenneth+C%3BNewes-Adeyi%2C+Gabriella+M%3BYoung%2C+Paul+A%3BGreene%2C+Amanda&rft.aulast=Taylor&rft.aufirst=Emmanuel&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integration of Criminal Justice and Substance Abuse Agencies: Measurement Concepts T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767975; 4780083 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fletcher, Bennett AU - Lehman, Wayne AU - Taxman, Faye S AU - Young, Douglas AU - Wexler, Harry AU - Melnik, Jerry Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Substance abuse KW - Integration KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Integration+of+Criminal+Justice+and+Substance+Abuse+Agencies%3A+Measurement+Concepts&rft.au=Fletcher%2C+Bennett%3BLehman%2C+Wayne%3BTaxman%2C+Faye+S%3BYoung%2C+Douglas%3BWexler%2C+Harry%3BMelnik%2C+Jerry&rft.aulast=Fletcher&rft.aufirst=Bennett&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Why aren't there More African-American Physicians? A Qualitative Study of African-American High-School Students' Perspectives T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767609; 4783302 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vijaya Rao, Glenn Flores Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Africa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Why+aren%27t+there+More+African-American+Physicians%3F+A+Qualitative+Study+of+African-American+High-School+Students%27+Perspectives&rft.au=Vijaya+Rao%2C+Glenn+Flores&rft.aulast=Vijaya+Rao&rft.aufirst=Glenn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Federal and Community Partnership to Develop a Culturally Competent CVD Prevention Curriculum for Native Hawai'ian Youths T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767436; 4783260 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Woo, Violet Ryo-Hwa AU - Alvarado, Matilde Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Federal+and+Community+Partnership+to+Develop+a+Culturally+Competent+CVD+Prevention+Curriculum+for+Native+Hawai%27ian+Youths&rft.au=Woo%2C+Violet+Ryo-Hwa%3BAlvarado%2C+Matilde&rft.aulast=Woo&rft.aufirst=Violet&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Health Insurance Parity Laws on Healthcare Coverage for Alcohol-Related Hospitalizations in the United States T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767412; 4780189 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Yoon, Young-Hee AU - Hilton, Michael E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Insurance KW - Health care KW - Parity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Effect+of+Health+Insurance+Parity+Laws+on+Healthcare+Coverage+for+Alcohol-Related+Hospitalizations+in+the+United+States&rft.au=Yi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BYoon%2C+Young-Hee%3BHilton%2C+Michael+E&rft.aulast=Yi&rft.aufirst=Hsiao-ye&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resurrection of Extinct Pathogens: A Smart Move? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767214; 4783398 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fee, Elizabeth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pathogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Resurrection+of+Extinct+Pathogens%3A+A+Smart+Move%3F&rft.au=Fee%2C+Elizabeth&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Virtual Reality to Develop and Test Educational Approaches for Abstract Scientific Concepts. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766860; 4781943 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Kaphingst, Kimberly AU - Persky, Susan AU - Lachance, Christina AU - McCall, Cade AU - Driskell, Sara AU - Beall, Andrew AU - Blascovich, James Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Computer applications KW - Education KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+Virtual+Reality+to+Develop+and+Test+Educational+Approaches+for+Abstract+Scientific+Concepts.&rft.au=Kaphingst%2C+Kimberly%3BPersky%2C+Susan%3BLachance%2C+Christina%3BMcCall%2C+Cade%3BDriskell%2C+Sara%3BBeall%2C+Andrew%3BBlascovich%2C+James&rft.aulast=Kaphingst&rft.aufirst=Kimberly&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recruitment of Participants to a Familial Cancer Study: Balancing Privacy Protection and Research Quality T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766846; 4782510 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Slutsman, Julia AU - Wideroff, Louise AU - Willis, Gordon AU - Graubard, Barry AU - Dunn, Marcia AU - McNeel, Tim Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Recruitment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Recruitment+of+Participants+to+a+Familial+Cancer+Study%3A+Balancing+Privacy+Protection+and+Research+Quality&rft.au=Slutsman%2C+Julia%3BWideroff%2C+Louise%3BWillis%2C+Gordon%3BGraubard%2C+Barry%3BDunn%2C+Marcia%3BMcNeel%2C+Tim&rft.aulast=Slutsman&rft.aufirst=Julia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Patient Navigators Assist Minority Patients and Improve Quality of their Care and Health Outcomes T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766692; 4782347 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colas, Maud AU - Freeman, Harold Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=How+Patient+Navigators+Assist+Minority+Patients+and+Improve+Quality+of+their+Care+and+Health+Outcomes&rft.au=Colas%2C+Maud%3BFreeman%2C+Harold&rft.aulast=Colas&rft.aufirst=Maud&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Typology of Violence Against Self and Others and its Associations with Drinking and Other Drug use among High School Students in a U.S. General Population Survey T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766649; 4780077 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Harford, Thomas C AU - Yi, Hsiao-ye AU - Freeman, Robert C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Violence KW - Drug abuse KW - Schools KW - Aggression KW - Typology KW - Drinking KW - Self KW - Population genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Typology+of+Violence+Against+Self+and+Others+and+its+Associations+with+Drinking+and+Other+Drug+use+among+High+School+Students+in+a+U.S.+General+Population+Survey&rft.au=Harford%2C+Thomas+C%3BYi%2C+Hsiao-ye%3BFreeman%2C+Robert+C&rft.aulast=Harford&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCI Smoke-Free Meeting Policy T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766283; 4780154 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - O'Connell, Mary Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=NCI+Smoke-Free+Meeting+Policy&rft.au=O%27Connell%2C+Mary&rft.aulast=O%27Connell&rft.aufirst=Mary&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institute on Alcohol Abuse and Alcoholism's Division of Epidemiology and Prevention Research Strategic Plan T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765656; 4780053 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hingson, Ralph W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Alcohols KW - Drug abuse KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=National+Institute+on+Alcohol+Abuse+and+Alcoholism%27s+Division+of+Epidemiology+and+Prevention+Research+Strategic+Plan&rft.au=Hingson%2C+Ralph+W&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do Americans Age 50 and Older Discuss the use of Complementary and Alternative Medicine (CAM) with their Physicians? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765438; 4782157 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Liu, Irene AU - Cotler, Alyssa AU - Law, Catherine AU - Thomsen, Chris AU - Hotra, Rives AU - Keenan, Teresa A AU - Brown, Helen W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Age KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Do+Americans+Age+50+and+Older+Discuss+the+use+of+Complementary+and+Alternative+Medicine+%28CAM%29+with+their+Physicians%3F&rft.au=Liu%2C+Irene%3BCotler%2C+Alyssa%3BLaw%2C+Catherine%3BThomsen%2C+Chris%3BHotra%2C+Rives%3BKeenan%2C+Teresa+A%3BBrown%2C+Helen+W&rft.aulast=Liu&rft.aufirst=Irene&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Being Proactive: Current Activities of the NIEHS Worker Education and Training Program and its Program Awardees in Preparing First Responders and Disaster Recovery Workers for Avian Influenza. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765433; 4782105 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Weinstock, Deborah L AU - Hughes, Joseph AU - Catlin, Mark D AU - Morawetz, John S AU - James, Xanthia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Training KW - Disasters KW - Education KW - Influenza KW - Fowl plague KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Being+Proactive%3A+Current+Activities+of+the+NIEHS+Worker+Education+and+Training+Program+and+its+Program+Awardees+in+Preparing+First+Responders+and+Disaster+Recovery+Workers+for+Avian+Influenza.&rft.au=Weinstock%2C+Deborah+L%3BHughes%2C+Joseph%3BCatlin%2C+Mark+D%3BMorawetz%2C+John+S%3BJames%2C+Xanthia&rft.aulast=Weinstock&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tailoring Evidence-Based Physical Activity Strategies in Minority Communities: One Size Does Not Fit All T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765347; 4784232 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Van Duyn, Mary Ann S. AU - McCrae, Tarsha AU - Wingrove, Barbara AU - Henderson, Kimberly M AU - Penalosa, Tricia L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Physical activity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Tailoring+Evidence-Based+Physical+Activity+Strategies+in+Minority+Communities%3A+One+Size+Does+Not+Fit+All&rft.au=Van+Duyn%2C+Mary+Ann+S.%3BMcCrae%2C+Tarsha%3BWingrove%2C+Barbara%3BHenderson%2C+Kimberly+M%3BPenalosa%2C+Tricia+L&rft.aulast=Van+Duyn&rft.aufirst=Mary+Ann&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Underage Hazardous Drinking and Failure to Graduate from High School: Results from the National Longitudinal Survey of Adolescent Health (Add Health) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765248; 4780181 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Falk, Daniel E AU - Hingson, Ralph W AU - Shirley, Mariela C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Adolescents KW - Schools KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Underage+Hazardous+Drinking+and+Failure+to+Graduate+from+High+School%3A+Results+from+the+National+Longitudinal+Survey+of+Adolescent+Health+%28Add+Health%29&rft.au=Falk%2C+Daniel+E%3BHingson%2C+Ralph+W%3BShirley%2C+Mariela+C&rft.aulast=Falk&rft.aufirst=Daniel&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clean Air Policies Sweep the Nation Improving Public Health Every Step of the Way T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765111; 4780152 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vollinger, Bob Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Clean+Air+Policies+Sweep+the+Nation+Improving+Public+Health+Every+Step+of+the+Way&rft.au=Vollinger%2C+Bob&rft.aulast=Vollinger&rft.aufirst=Bob&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Capacity in Formative Evaluation: The Role of CHWs T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764646; 4782250 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Wallace, Madeleine F AU - Rangel, Lourdes AU - Alvarado, Matilde AU - Ortiz, Gloria AU - Cate, Gladys Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Building+Capacity+in+Formative+Evaluation%3A+The+Role+of+CHWs&rft.au=Wallace%2C+Madeleine+F%3BRangel%2C+Lourdes%3BAlvarado%2C+Matilde%3BOrtiz%2C+Gloria%3BCate%2C+Gladys&rft.aulast=Wallace&rft.aufirst=Madeleine&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial and Ethnic Differences in Factors Affecting Treatment of Alcohol and Drug use Disorders T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764433; 4780065 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Smith, Sharon M AU - Goldstein, Rise B AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Alcohols KW - Drug abuse KW - U 2000:Bi