TY - JOUR T1 - Co-expression of the toleragenic glycoprotein, CD200, with markers for cancer stem cells AN - 19467639; 7938277 AB - Tumor immunology fundamentals suggest immunological surveillance has the ability to recognize malignant cells and kill them before a tumor develops. However, cancer cells employ evasion mechanisms whereby the immune system may be actively suppressed or even tolerized to the tumor. Recently cancer stem cells were linked to tumor initiation and formation. However, no reports have addressed whether these cells participate in a tumor's ability to evade immune surveillance. Recently the glycoprotein CD200, expressed within the innate immune system and other tissues and cells, was shown to be involved in tolerance. Here we describe CD200 co-expression with stem cell markers found on prostate, breast, brain, and colon cancers. This is the first report describing an immunomodulatory molecule on epithelial cancer stem cells. This important finding suggests a mechanism by which a tumor might evades immune system detection. JF - Biochemical and Biophysical Research Communications AU - Kawasaki, B T AU - Mistree, T AU - Hurt, E M AU - Kalathur, M AU - Farrar, W L AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health Frederick, 1050 Boyles Street, Building 560, Room 21-81, MD 21702, USA, kawasakib@mail.nih.gov Y1 - 2007/12/28/ PY - 2007 DA - 2007 Dec 28 SP - 778 EP - 782 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 4 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - CD200 antigen KW - Immunosurveillance KW - Immune system KW - Brain KW - Tumors KW - Glycoproteins KW - Colon cancer KW - Prostate KW - Immunological tolerance KW - F 06915:Cancer Immunology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Co-expression+of+the+toleragenic+glycoprotein%2C+CD200%2C+with+markers+for+cancer+stem+cells&rft.au=Kawasaki%2C+B+T%3BMistree%2C+T%3BHurt%2C+E+M%3BKalathur%2C+M%3BFarrar%2C+W+L&rft.aulast=Kawasaki&rft.aufirst=B&rft.date=2007-12-28&rft.volume=364&rft.issue=4&rft.spage=778&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Stem cells; CD200 antigen; Immunosurveillance; Immune system; Brain; Colon cancer; Glycoproteins; Tumors; Immunological tolerance; Prostate DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.067 ER - TY - JOUR T1 - Phorbol myristate acetate-induced Egr-1 expression is suppressed by phospholipase D isozymes in human glioma cells. AN - 69065348; 18067864 AB - Early growth response-1 (Egr-1) is involved in the regulation of cell growth. Here, we found that overexpression of phospholipase D (PLD) isozymes decreased tumor promoter phorbol myristate acetate (PMA)-induced Egr-1 expression and transactivation in glioma cells. Suppression of PMA-induced Egr-1 was dependent on the expression level of PLD isozymes. Overexpression of catalytically inactive PLD, treatment with PA, and prevention of PA dephosphorylation by 1-propranolol significantly suppressed PMA-induced Egr-1 expression. PLD-induced suppression of Egr-1 was reversed by inhibition of phosphatidylinositol 3-kinase (PI3K). Taken together, these results suggest that elevated expression and activity of PLD attenuate PMA-induced Egr-1 expression via PI3K pathway. JF - FEBS letters AU - Ahn, Bong-Hyun AU - Park, Mi Hee AU - Lee, Young Han AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute, NIH Bldg 10/CRC 5-3288, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/12/22/ PY - 2007 DA - 2007 Dec 22 SP - 5940 EP - 5944 VL - 581 IS - 30 SN - 0014-5793, 0014-5793 KW - EGR1 protein, human KW - 0 KW - Early Growth Response Protein 1 KW - Isoenzymes KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - Phospholipase D KW - EC 3.1.4.4 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Humans KW - Genes, Reporter KW - Transcriptional Activation -- drug effects KW - Cell Line, Tumor KW - Response Elements KW - Isoenzymes -- metabolism KW - Phospholipase D -- metabolism KW - Glioma -- pathology KW - Early Growth Response Protein 1 -- metabolism KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Early Growth Response Protein 1 -- genetics KW - Glioma -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69065348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Phorbol+myristate+acetate-induced+Egr-1+expression+is+suppressed+by+phospholipase+D+isozymes+in+human+glioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BPark%2C+Mi+Hee%3BLee%2C+Young+Han%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2007-12-22&rft.volume=581&rft.issue=30&rft.spage=5940&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-05 N1 - Date created - 2007-12-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. AN - 69081849; 18154267 AB - Activation of the signal transducer and activator of transcription 3 (STAT3) is frequently detected in many cancer types. Activated STAT3 may participate in oncogenesis by stimulating cell proliferation and resisting apoptosis, as well as promoting tumor angiogenesis, invasion, and migration. Many STAT3-dependent cellular responses are mediated through interactions with other proteins, and the amino-terminal domain (N-domain) of STAT3 was proposed to be responsible for this. Our NMR studies revealed that synthetic analogs of the STAT4 second alpha-helix bind to the N-domain and perturb its structure. Structural data available for the STAT4 N-domain was used for the rational design of STAT3 helix 2 analogs with enhanced biological activity. Cell-permeable derivatives of the STAT3 second helix were found to directly and specifically bind to STAT3 but not STAT1 as determined by FRET analysis in cells expressing GFP-STAT3 and GFP-STAT1. Furthermore, they potently induced apoptotic death in breast cancer cells but not normal breast cells or STAT3-deficient fibroblasts. The inhibitors caused significant changes in the mitochondrial potential of cancer cells, leading to cell death. These compounds not only are promising drug candidates but also offer a convenient tool for studying the mechanisms of action of STAT transcription factors and have facilitated our understanding of the crucial role of the N-domain in STAT3 function. JF - ACS chemical biology AU - Timofeeva, Olga A AU - Gaponenko, Vadim AU - Lockett, Stephen J AU - Tarasov, Sergey G AU - Jiang, Sheng AU - Michejda, Christopher J AU - Perantoni, Alan O AU - Tarasova, Nadya I AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute, NCI-Frederick, Maryland 21702, USA. Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 799 EP - 809 VL - 2 IS - 12 KW - Antineoplastic Agents KW - 0 KW - STAT3 Transcription Factor KW - Index Medicus KW - Cell Survival -- drug effects KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Protein Structure, Tertiary KW - STAT3 Transcription Factor -- antagonists & inhibitors KW - Antineoplastic Agents -- toxicity KW - STAT3 Transcription Factor -- genetics KW - STAT3 Transcription Factor -- metabolism KW - STAT3 Transcription Factor -- chemistry KW - Antineoplastic Agents -- chemistry KW - Drug Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69081849?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+chemical+biology&rft.atitle=Rationally+designed+inhibitors+identify+STAT3+N-domain+as+a+promising+anticancer+drug+target.&rft.au=Timofeeva%2C+Olga+A%3BGaponenko%2C+Vadim%3BLockett%2C+Stephen+J%3BTarasov%2C+Sergey+G%3BJiang%2C+Sheng%3BMichejda%2C+Christopher+J%3BPerantoni%2C+Alan+O%3BTarasova%2C+Nadya+I&rft.aulast=Timofeeva&rft.aufirst=Olga&rft.date=2007-12-21&rft.volume=2&rft.issue=12&rft.spage=799&rft.isbn=&rft.btitle=&rft.title=ACS+chemical+biology&rft.issn=1554-8937&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-12-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fluorinated alcohol mediated displacement of the C10 acetoxy group of benzo[a]pyrene-7,8,9,10-tetrahydrotetraol tetraacetates: a new route to diol epoxide-deoxyguanosine adducts. AN - 69061447; 18047370 AB - We describe a novel trifluoroethanol (TFE) or hexafluoropropan-2-ol (HFP) mediated substitution reaction of the bay-region C10 acetoxy group in four stereoisomeric 7,8,9,10-tetraacetoxy-7,8,9,10-tetrahydrobenzo[a]pyrenes (tetraol tetraacetates, two pairs of cis and trans isomers at the 9,10 positions) by the exocyclic N2-amino group of O6-allyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine (3). The tetraacetates are derived from cis and trans hydrolysis of (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P DE-1) and of (+/-)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P DE-2) at C-10 followed by acetylation. Excellent yields and high regioselectivity were observed. Similar cis/trans product ratios were observed for each set of cis and trans tetraol tetraacetates derived from DE-1 ( approximately 75/25) and from DE-2 (approximately 67/33) in HFP. This strongly suggests that the substitution proceeds via an SN1 mechanism involving a carbocation intermediate that is common to the cis and trans tetraacetates. Since it is likely that the cis and trans products from 3 arise from different conformations of the carbocation, its lifetime must be sufficiently long to permit conformational equilibration before its capture by the purine nucleophile. The corresponding reaction of (+/-)-9alpha-bromo-7beta,8alpha,10beta-triacetoxy-7,8,9,10-tetrahydrobenzo[a]pyrene with 3 in HFP was highly regio- and stereoselective and gave exclusively trans 10beta-adducts. This newly developed substitution reaction provides an attractive alternative synthetic strategy for the preparation of polycyclic hydrocarbon adducted oligonucleotide building blocks. JF - The Journal of organic chemistry AU - Yagi, Haruhiko AU - Jerina, Donald M AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 9983 EP - 9990 VL - 72 IS - 26 SN - 0022-3263, 0022-3263 KW - DNA Adducts KW - 0 KW - O(6)-allyl-3',5'-di-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine KW - Organosilicon Compounds KW - Propanols KW - hexafluoroisopropanol KW - 3D632GYQ50 KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Trifluoroethanol KW - 75-89-8 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Stereoisomerism KW - Molecular Conformation KW - Hydrolysis KW - Trifluoroethanol -- chemistry KW - Organosilicon Compounds -- chemistry KW - DNA Adducts -- chemistry KW - Deoxyguanosine -- chemical synthesis KW - Deoxyguanosine -- chemistry KW - DNA Adducts -- chemical synthesis KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry KW - Propanols -- chemistry KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+organic+chemistry&rft.atitle=Fluorinated+alcohol+mediated+displacement+of+the+C10+acetoxy+group+of+benzo%5Ba%5Dpyrene-7%2C8%2C9%2C10-tetrahydrotetraol+tetraacetates%3A+a+new+route+to+diol+epoxide-deoxyguanosine+adducts.&rft.au=Yagi%2C+Haruhiko%3BJerina%2C+Donald+M&rft.aulast=Yagi&rft.aufirst=Haruhiko&rft.date=2007-12-21&rft.volume=72&rft.issue=26&rft.spage=9983&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+organic+chemistry&rft.issn=00223263&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutations that alter the equilibrium between open and closed conformations of Escherichia coli maltose-binding protein impede its ability to enhance the solubility of passenger proteins AN - 20397146; 7786467 AB - Certain highly soluble proteins, such as Escherichia coli maltose-binding protein (MBP), have the ability to enhance the solubility of their fusion partners, making them attractive vehicles for the production of recombinant proteins, yet the mechanism of solubility enhancement remains poorly understood. Here, we report that the solubility-enhancing properties of MBP are dramatically affected by amino acid substitutions that alter the equilibrium between its ''open'' and ''closed'' conformations. Our findings indicate that the solubility-enhancing activity of MBP is mediated by its open conformation and point to a likely role for the ligand-binding cleft in the mechanism of solubility enhancement. JF - Biochemical and Biophysical Research Communications AU - Nallamsetty, S AU - Waugh, D S AD - Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702-1201, USA, waughd@ncifcrf.gov Y1 - 2007/12/21/ PY - 2007 DA - 2007 Dec 21 SP - 639 EP - 644 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 364 IS - 3 SN - 0006-291X, 0006-291X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Solubility KW - Amino acid substitution KW - Escherichia coli KW - maltose-binding protein KW - Mutation KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Mutations+that+alter+the+equilibrium+between+open+and+closed+conformations+of+Escherichia+coli+maltose-binding+protein+impede+its+ability+to+enhance+the+solubility+of+passenger+proteins&rft.au=Nallamsetty%2C+S%3BWaugh%2C+D+S&rft.aulast=Nallamsetty&rft.aufirst=S&rft.date=2007-12-21&rft.volume=364&rft.issue=3&rft.spage=639&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2007.10.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Solubility; maltose-binding protein; Mutation; Escherichia coli DO - http://dx.doi.org/10.1016/j.bbrc.2007.10.060 ER - TY - JOUR T1 - Chitosan solution enhances the immunoadjuvant properties of GM-CSF. AN - 69048242; 18037196 AB - Sustained, local delivery of immunomodulatory cytokines is under investigation for its ability to enhance vaccine and anti-tumor responses both clinically and preclinically. This study evaluates the ability of chitosan, a biocompatible polysaccharide, to (1) control the dissemination of a cytokine, GM-CSF, and (2) enhance the immunoadjuvant properties of GM-CSF. While cytokines have previously been delivered in lipid-based adjuvants and other vehicles, these do not have the clinical safety profile or unique properties of chitosan. We found that chitosan solution maintained a measurable depot of recombinant GM-CSF (rGM-CSF) at a subcutaneous injection site for up to 9 days. In contrast, when delivered in a saline vehicle, rGM-CSF was undetectable in 12-24h. Furthermore, a single s.c. injection of 20 microg rGM-CSF in chitosan solution (chitosan/rGM-CSF(20 microg)) transiently expanded lymph nodes up to 4.6-fold and increased the number of MHC class II expressing cells and dendritic cells by 7.4-fold and 6.8-fold, respectively. These increases were significantly greater than those measured when rGM-CSF was administered in saline at the standard preclinical dose and schedule, i.e. 4 daily s.c. injections of 20 microg. Furthermore, lymph node cells from mice injected with chitosan/rGM-CSF(20 microg) induced greater allogeneic T cell proliferation, indicating enhanced antigen presenting capability, than lymph node cells from mice injected with rGM-CSF alone. Finally, in vaccination experiments, chitosan/rGM-CSF was superior to either chitosan or rGM-CSF alone in enhancing the induction of antigen-specific CD4(+) proliferation, peptide-specific CD8(+) pentamer staining and cytotoxic T cell lysis. Altogether, chitosan/rGM-CSF outperformed standard rGM-CSF administrations in dendritic cell recruitment, antigen presentation and vaccine enhancement. We conclude that chitosan solution is a promising delivery platform for the sustained, local delivery of rGM-CSF. JF - Vaccine AU - Zaharoff, David A AU - Rogers, Connie J AU - Hance, Kenneth W AU - Schlom, Jeffrey AU - Greiner, John W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, United States. Y1 - 2007/12/17/ PY - 2007 DA - 2007 Dec 17 SP - 8673 EP - 8686 VL - 25 IS - 52 SN - 0264-410X, 0264-410X KW - Adjuvants, Immunologic KW - 0 KW - Delayed-Action Preparations KW - Histocompatibility Antigens Class II KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Chitosan KW - 9012-76-4 KW - Index Medicus KW - Animals KW - Dendritic Cells -- immunology KW - Histocompatibility Antigens Class II -- genetics KW - Gene Expression KW - CD4-Positive T-Lymphocytes -- immunology KW - Delayed-Action Preparations -- administration & dosage KW - T-Lymphocytes, Cytotoxic -- immunology KW - Mice KW - Cell Proliferation KW - Antigen Presentation -- immunology KW - Adjuvants, Immunologic -- administration & dosage KW - CD8-Positive T-Lymphocytes -- immunology KW - Injections, Subcutaneous KW - Lymphocyte Subsets -- immunology KW - Cytotoxicity Tests, Immunologic KW - Female KW - Lymph Nodes -- immunology KW - Granulocyte-Macrophage Colony-Stimulating Factor -- administration & dosage KW - Granulocyte-Macrophage Colony-Stimulating Factor -- immunology KW - Chitosan -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69048242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Chitosan+solution+enhances+the+immunoadjuvant+properties+of+GM-CSF.&rft.au=Zaharoff%2C+David+A%3BRogers%2C+Connie+J%3BHance%2C+Kenneth+W%3BSchlom%2C+Jeffrey%3BGreiner%2C+John+W&rft.aulast=Zaharoff&rft.aufirst=David&rft.date=2007-12-17&rft.volume=25&rft.issue=52&rft.spage=8673&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Trauma. 2006 Mar;60(3):655-8 [16531872] J Pharm Sci. 2004 May;93(5):1100-9 [15067687] Vaccine. 2004 Feb 25;22(8):909-14 [15161067] Cancer Res. 2004 Sep 1;64(17):6337-43 [15342423] Blood. 1980 Dec;56(6):947-58 [7002232] J Immunol. 1987 Aug 15;139(4):1113-9 [3038997] Cancer Res. 1993 Dec 15;53(24):5841-4 [8261390] JAMA. 1994 Mar 23-30;271(12):907-13 [8120958] Cytokine. 1994 Jan;6(1):92-101 [8003640] J Clin Oncol. 1995 Mar;13(3):688-96 [7884429] Int J Cancer. 1996 Jul 3;67(1):54-62 [8690525] Blood. 1996 Jul 1;88(1):202-10 [8704175] Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10972-7 [8855293] J Pharm Sci. 1996 Dec;85(12):1261-70 [8961136] Vaccine. 1996 Sep;14(13):1199-204 [8961505] Blood. 1997 Oct 1;90(7):2541-8 [9326219] Curr Opin Immunol. 2004 Feb;16(1):108-13 [14734118] Ann Surg Oncol. 2004 Feb;11(2):147-56 [14761917] Am J Clin Nutr. 2004 Apr;79(4):529-36 [15051593] Pharm Res. 1997 Oct;14(10):1422-30 [9358556] Clin Cancer Res. 1998 Aug;4(8):1881-6 [9717815] Science. 1998 Aug 21;281(5380):1161-2 [9735031] J Immunother. 1999 Mar;22(2):166-74 [10093041] J Immunol. 1999 May 15;162(10):5728-37 [10229805] J Immunol. 2005 Jan 15;174(2):898-906 [15634912] Obes Rev. 2005 Feb;6(1):35-42 [15655037] Cancer Biother Radiopharm. 2004 Dec;19(6):764-9 [15665625] J Clin Oncol. 2005 Feb 1;23(4):720-31 [15613691] Vaccine. 2005 Apr 22;23(22):2909-21 [15780740] Clin Cancer Res. 2005 May 1;11(9):3353-62 [15867235] Vaccine. 2005 Aug 15;23(35):4367-74 [15916838] J Immunother. 2006 Jan-Feb;29(1):10-20 [16365596] J Interferon Cytokine Res. 2006 Jun;26(6):380-9 [16734558] Drug Dev Ind Pharm. 2006 Jul;32(6):699-707 [16885125] J Surg Oncol. 2006 Oct 1;94(5):403-12 [16967445] Drug Dev Ind Pharm. 2003 Nov;29(10):1149-53 [14677775] J Immunol. 2006 Nov 15;177(10):6962-73 [17082611] Int Rev Immunol. 2006 Sep-Dec;25(5-6):321-52 [17169779] J Immunol. 2007 Feb 15;178(4):2182-91 [17277123] Ann Oncol. 2007 Feb;18(2):226-32 [17116643] Vaccine. 2007 Mar 1;25(11):2085-94 [17258843] J Immunother. 1999 Nov;22(6):525-38 [10570751] Pharm Res. 2000 Jan;17(1):42-8 [10714607] Pharm Res. 2000 Jan;17(1):100-6 [10714616] J Immunother. 2000 Mar-Apr;23(2):190-5 [10746545] Clin Immunol. 2000 Jul;96(1):29-37 [10873425] Cytokine. 2000 Jul;12(7):960-71 [10880241] Pharm Res. 2000 Oct;17(10):1159-67 [11145219] Cancer Res. 2001 Jan 1;61(1):206-14 [11196163] Biochim Biophys Acta. 2001 Mar 30;1531(1-2):99-110 [11278176] Pharm Res. 2001 Jul;18(7):899-906 [11496947] J Pharm Pharmacol. 2001 Aug;53(8):1047-67 [11518015] Crit Rev Ther Drug Carrier Syst. 2001;18(6):551-66 [11789675] J Pharm Sci. 2002 May;91(5):1245-51 [11977100] Infect Immun. 2003 Feb;71(2):726-32 [12540551] Eur J Pharm Sci. 2003 Mar;18(3-4):221-9 [12659933] J Control Release. 2003 Sep 4;91(3):299-313 [12932709] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacokinetic and tumor distribution characteristics of temsirolimus in patients with recurrent malignant glioma. AN - 69081164; 18094423 AB - To characterize the pharmacokinetics of temsirolimus and its major metabolite, sirolimus, in patients receiving enzyme-inducing antiepileptic drugs (EIAED) compared with patients receiving non-EIAEDs. An additional objective was to determine whether concentrations of temsirolimus or sirolimus were achieved in brain tumor tissue. Patients with recurrent malignant gliomas not receiving EIAEDs initially received temsirolimus weekly at a dose of 250 mg i.v. The dose was subsequently reduced to 170 mg due to intolerable side effects. For patients taking EIAEDs, the starting dose of temsirolimus was 250 mg with standard dose escalation until the maximal tolerated dose was established. Ten whole blood samples were obtained over a period of 24 h after administration of temsirolimus for pharmacokinetic assessments. Patients eligible for cytoreductive surgery received temsirolimus before tumor resection. Whole blood and tumor tissue were obtained for analysis. Significant differences in the pharmacokinetic variables for temsirolimus and sirolimus were observed between the two patient groups at a comparable dose level of 250 mg. For patients receiving EIAEDs, the systemic exposure to temsirolimus was lower by 1.5-fold. Likewise, peak concentrations and exposure to sirolimus were lower by 2-fold. Measurable concentrations of temsirolimus and sirolimus were observed in brain tumor specimens. The average tissue to whole blood ratio for temsirolimus was 1.43 and 0.84 for sirolimus. Drugs that induce cytochrome P450 3A4, such as EIAEDs, significantly affect the pharmacokinetics of temsirolimus and its active metabolite, sirolimus. Total exposure to temsirolimus and sirolimus was lower in the EIAED group at the maximum tolerated dose of 250 mg compared with the non-EIAED group at the maximum tolerated dose of 170 mg. However, brain tumor tissue concentrations of temsirolimus and sirolimus were relatively comparable in both groups of patients at their respective dose levels. Correlative analyses of the tissue for the inhibition of the key regulators (p70S6 kinase and 4E-binding protein 1) of mammalian target of rapamycin are necessary to define the therapeutic significance of the altered exposure to temsirolimus. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kuhn, John G AU - Chang, Susan M AU - Wen, Patrick Y AU - Cloughesy, Timothy F AU - Greenberg, Harry AU - Schiff, David AU - Conrad, Charles AU - Fink, Karen L AU - Robins, H Ian AU - Mehta, Minesh AU - DeAngelis, Lisa AU - Raizer, Jeffrey AU - Hess, Kenneth AU - Lamborn, Kathleen R AU - Dancey, Janet AU - Prados, Michael D AU - North American Brain Tumor Consortium and the National Cancer Institute AD - Pharmacotherapy Education and Research Center, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. Kuhn@uthscsa.edu ; North American Brain Tumor Consortium and the National Cancer Institute Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 7401 EP - 7406 VL - 13 IS - 24 SN - 1078-0432, 1078-0432 KW - Anticonvulsants KW - 0 KW - Antineoplastic Agents KW - temsirolimus KW - 624KN6GM2T KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Drug Interactions KW - Neoplasm Recurrence, Local -- drug therapy KW - Area Under Curve KW - Humans KW - Metabolic Clearance Rate KW - Cytochrome P-450 Enzyme System -- metabolism KW - Maximum Tolerated Dose KW - Cytochrome P-450 Enzyme System -- drug effects KW - Glioma -- drug therapy KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- surgery KW - Antineoplastic Agents -- pharmacokinetics KW - Sirolimus -- pharmacokinetics KW - Anticonvulsants -- therapeutic use KW - Glioma -- surgery KW - Sirolimus -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69081164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=An+HIV+RNase+H+Inhibitory+1%2C3%2C4%2C5-Tetragalloylapiitol+from+the+African+Plant+Hylodendron+gabunensis&rft.au=Takada%2C+K%3BBermingham%2C+A%3BO%27Keefe%2C+B+R%3BWamiru%2C+A%3BBeutler%2C+JA%3BLe+Grice%2C+SFJ%3BLloyd%2C+J%3BGustafson%2C+K+R%3BMcMahon%2C+J+B&rft.aulast=Takada&rft.aufirst=K&rft.date=2007-10-01&rft.volume=70&rft.issue=10&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp0702279 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional diversity of human protection of telomeres 1 isoforms in telomere protection and cellular senescence. AN - 69076134; 18089797 AB - Protection of telomeres 1 (POT1) proteins in various organisms bind telomeres and regulate their structure and function. In contrast to mice carrying two distinct POT1 genes encoding two POT1 proteins (POT1a and POT1b), humans have the single POT1 gene. In addition to full-length POT1 protein (variant v1), the human POT1 gene encodes four other variants due to alternative RNA splicing (variants v2, v3, v4, and v5), whose functions are poorly understood. The functional analyses of the NH(2)-terminally and COOH-terminally truncated POT1 variants in this study showed that neither the single-stranded telomere-binding ability of the NH(2)-terminal oligonucleotide-binding (OB) folds nor the telomerase-dependent telomere elongation activity mediated by the COOH-terminal TPP1-interacting domain was telomere protective by itself. Importantly, a COOH-terminally truncated variant (v5), which consists of the NH(2)-terminal OB folds and the central region of unknown function, was found to protect telomeres and prevent cellular senescence as efficiently as v1. Our data revealed mechanistic and functional differences between v1 and v5: (a) v1, but not v5, functions through the maintenance of telomeric 3' overhangs; (b) p53 is indispensable to v5 knockdown-induced senescence; and (c) v5 functions at only a fraction of telomeres to prevent DNA damage signaling. Furthermore, v5 was preferentially expressed in mismatch repair (MMR)-deficient cells and tumor tissues, suggesting its role in chromosome stability associated with MMR deficiency. This study highlights a human-specific complexity in telomere protection and damage signaling conferred by functionally distinct isoforms from the single POT1 gene. JF - Cancer research AU - Yang, Qin AU - Zhang, Ran AU - Horikawa, Izumi AU - Fujita, Kaori AU - Afshar, Yalda AU - Kokko, Antti AU - Laiho, Päivi AU - Aaltonen, Lauri A AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4258, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 11677 EP - 11686 VL - 67 IS - 24 KW - POT1 protein, human KW - 0 KW - RNA, Catalytic KW - Telomere-Binding Proteins KW - hairpin ribozyme KW - Index Medicus KW - RNA, Catalytic -- genetics KW - Alternative Splicing KW - Humans KW - Foreskin -- physiology KW - Telomere-Binding Proteins -- physiology KW - Telomere-Binding Proteins -- genetics KW - Gene Expression Regulation KW - Cell Line, Tumor KW - Foreskin -- cytology KW - Male KW - Cell Line KW - Fibroblasts -- physiology KW - Genetic Variation KW - Telomere -- physiology KW - Cell Aging -- physiology KW - Telomere -- genetics KW - Cell Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Functional+diversity+of+human+protection+of+telomeres+1+isoforms+in+telomere+protection+and+cellular+senescence.&rft.au=Sommer%2C+W+H%3BRimondini%2C+R%3BMarquitz%2C+M%3BLidstr%C3%B6m%2C+J%3BSiems%2C+W-E%3BBader%2C+M%3BHeilig%2C+M&rft.aulast=Sommer&rft.aufirst=W&rft.date=2007-10-01&rft.volume=85&rft.issue=10&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.issn=09462716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase 2 study of pegylated liposomal doxorubicin in combination with interleukin-12 for AIDS-related Kaposi sarcoma. AN - 69027341; 17846226 AB - Thirty-six patients with AIDS-associated Kaposi sarcoma (KS) requiring chemotherapy were treated for six 3-week cycles of pegylated liposomal doxorubicin (20 mg/m(2)) plus interleukin-12 (IL-12; 300 ng/kg subcutaneously twice weekly), followed by 500 ng/kg subcutaneous IL-12 twice weekly for up to 3 years. All received highly active antiretroviral therapy (HAART). Twenty-two had poor-prognosis KS (T(1)S(1)). Thirty patients had a major response, including 9 with complete response, yielding an 83.3% major response rate (95% confidence interval: 67.2%-93.6%). Median time to first response was 2 cycles. Median progression was not reached at median potential follow-up of 46.9 months. Of 27 patients with residual disease when starting maintenance IL-12, 15 had a new major response compared with this new baseline. The regimen was overall well tolerated; principal toxicities were neutropenia, anemia, transaminitis, and neuropsychiatric toxicity. Patients had increases in serum IL-12, interferon gamma, and inducible protein-10 (IP-10), and these remained increased at weeks 18 and 34. The regimen of IL-12 plus liposomal doxorubicin yielded rapid tumor responses and a high response rate in patients with AIDS-KS receiving HAART, and responses were sustained on IL-12 maintenance therapy. A randomized trial of IL-12 in this setting may be warranted. This study is registered at (http://www.clinicaltrials.gov) as no. NCT00020449. JF - Blood AU - Little, Richard F AU - Aleman, Karen AU - Kumar, Pallavi AU - Wyvill, Kathleen M AU - Pluda, James M AU - Read-Connole, Elizabeth AU - Wang, Victoria AU - Pittaluga, Stefania AU - Catanzaro, Andrew T AU - Steinberg, Seth M AU - Yarchoan, Robert AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1868, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 4165 EP - 4171 VL - 110 IS - 13 SN - 0006-4971, 0006-4971 KW - CXCL10 protein, human KW - 0 KW - Chemokine CXCL10 KW - liposomal doxorubicin KW - Interleukin-12 KW - 187348-17-0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Doxorubicin KW - 80168379AG KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - AIDS-Related Opportunistic Infections -- drug therapy KW - Chemokine CXCL10 -- blood KW - Humans KW - Adult KW - Treatment Outcome KW - Antiretroviral Therapy, Highly Active KW - Middle Aged KW - Interferon-gamma -- blood KW - Remission Induction KW - Sarcoma, Kaposi -- drug therapy KW - Acquired Immunodeficiency Syndrome -- complications KW - Doxorubicin -- analogs & derivatives KW - Interleukin-12 -- administration & dosage KW - Polyethylene Glycols -- toxicity KW - Doxorubicin -- toxicity KW - Doxorubicin -- administration & dosage KW - Polyethylene Glycols -- administration & dosage KW - Interleukin-12 -- blood KW - Interleukin-12 -- toxicity KW - Sarcoma, Kaposi -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=Phase+2+study+of+pegylated+liposomal+doxorubicin+in+combination+with+interleukin-12+for+AIDS-related+Kaposi+sarcoma.&rft.au=Little%2C+Richard+F%3BAleman%2C+Karen%3BKumar%2C+Pallavi%3BWyvill%2C+Kathleen+M%3BPluda%2C+James+M%3BRead-Connole%2C+Elizabeth%3BWang%2C+Victoria%3BPittaluga%2C+Stefania%3BCatanzaro%2C+Andrew+T%3BSteinberg%2C+Seth+M%3BYarchoan%2C+Robert&rft.aulast=Little&rft.aufirst=Richard&rft.date=2007-12-15&rft.volume=110&rft.issue=13&rft.spage=4165&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-14 N1 - Genetic sequence - NCT00020449; ClinicalTrials.gov N1 - SuppNotes - Cited By: Clin Exp Immunol. 2000 Jan;119(1):28-37 [10606961] J Exp Med. 1998 Jul 20;188(2):405-8 [9670053] Cancer Res. 2000 Sep 1;60(17):4873-80 [10987301] J Infect Dis. 2001 Apr 1;183(7):1116-20 [11237839] AIDS. 2001 Mar 30;15(5):629-33 [11317001] HIV Clin Trials. 2001 Sep-Oct;2(5):429-37 [11673818] J Invest Dermatol. 2001 Oct;117(4):858-63 [11676823] AIDS. 2002 May 24;16(8):1147-54 [12004273] J Natl Cancer Inst. 2002 Aug 21;94(16):1204-10 [12189223] J Infect Dis. 2003 Jan 1;187(1):149-53 [12508160] Clin Cancer Res. 2003 Jan;9(1):76-83 [12538454] AIDS. 2004 Aug 20;18(12):1737-40 [15280789] Technol Cancer Res Treat. 2004 Oct;3(5):451-7 [15453810] N Engl J Med. 1985 Jul 11;313(2):79-84 [2582258] J Biol Response Mod. 1985 Aug;4(4):358-64 [3928825] Control Clin Trials. 1989 Mar;10(1):1-10 [2702835] J Exp Med. 1989 Sep 1;170(3):827-45 [2504877] J Clin Oncol. 1989 Sep;7(9):1201-7 [2671281] Immunol Today. 1991 Oct;12(10):346-8 [1683536] Am J Epidemiol. 1993 Aug 15;138(4):266-78 [8356967] J Exp Med. 1993 Oct 1;178(4):1223-30 [8104230] Blood. 1993 Nov 1;82(9):2790-6 [8106018] Clin Oncol (R Coll Radiol). 1993;5(6):367-71 [8305357] J Acquir Immune Defic Syndr. 1994 May;7(5):463-8 [8158540] Eur J Cancer. 1998 Dec;34(13):2101-6 [10070318] Clin Cancer Res. 1999 Jul;5(7):1905-17 [10430098] J Clin Oncol. 2005 Feb 10;23(5):990-8 [15598977] J Acquir Immune Defic Syndr. 2005 Jul 1;39(3):293-9 [15980688] Int J Oncol. 2005 Sep;27(3):779-85 [16077928] Nat Clin Pract Oncol. 2005 Aug;2(8):406-15; quiz 423 [16130937] Blood. 2006 Jun 15;107(12):4650-7 [16507779] J Clin Oncol. 2003 Aug 1;21(15):2876-82 [12885804] J Clin Oncol. 2004 Feb 1;22(3):399-402 [14752065] N Engl J Med. 2004 Jun 3;350(23):2335-42 [15175435] Cancer. 2004 Jul 15;101(2):317-24 [15241829] J Immunol. 1994 Aug 15;153(4):1697-706 [7913943] Blood. 1994 Dec 15;84(12):4008-27 [7994020] Science. 1994 Dec 16;266(5192):1865-9 [7997879] Blood. 1996 May 1;87(9):3877-82 [8611715] Cancer Chemother Pharmacol. 1996;38(2):169-77 [8616908] J Leukoc Biol. 1996 May;59(5):623-30 [8656046] J Virol. 1996 Nov;70(11):8218-23 [8892957] Blood. 1997 Apr 15;89(8):2635-43 [9108380] J Immunol. 1997 May 15;158(10):4992-5001 [9144519] J Clin Oncol. 1997 Sep;15(9):3085-92 [9294471] Nature. 1998 Jan 1;391(6662):86-9 [9422510] Cancer Chemother Pharmacol. 1998;41(6):497-504 [9554595] AIDS. 2000 May 26;14(8):987-93 [10853980] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Corpus callosum abnormalities associated with greater externalizing behaviors in subjects at high risk for alcohol dependence. AN - 68545995; 17959361 AB - Subjects at high risk for alcoholism have a greater propensity for externalizing behaviors and brain volume reductions of possible neurodevelopmental origin. Morphometric deficits in the corpus callosum (CC), which might reflect this neurodevelopmental abnormality, have been reported in other externalizing disorders such as attention deficit hyperactivity disorder, but not in subjects at high risk for alcoholism. The objective of the current study was to evaluate the CC morphometry in subjects at high risk for alcoholism. Magnetic resonance images of the CC in high-risk subjects (n=20) were compared with those of low-risk subjects matched to the high-risk subjects for age, sex, and handedness (n=20). Mid-sagittal areas of the CC, genu, body, isthmus and splenium were measured based on Witelson's method with good inter- and intra-rater reliability. Externalizing behaviors were assessed using the Semi-Structured Assessment for Genetics of Alcoholism-II. Total CC, genu and isthmus areas were significantly smaller in high-risk than low-risk subjects after controlling for age and intracranial area. The total externalizing symptoms score had a significant negative correlation with genu and isthmus areas. Smaller CC areas and their negative association with externalizing behaviors may represent yet another marker of susceptibility to alcoholism in high-risk subjects. JF - Psychiatry research AU - Venkatasubramanian, Ganesan AU - Anthony, George AU - Reddy, Umesh Srinivasa AU - Reddy, Varun Venkatesh AU - Jayakumar, Peruvumba N AU - Benegal, Vivek AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, India. gvs@nimhans.kar.nic.in Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 209 EP - 215 VL - 156 IS - 3 SN - 0165-1781, 0165-1781 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Image Interpretation, Computer-Assisted KW - Risk Factors KW - Humans KW - Adult KW - Child of Impaired Parents -- statistics & numerical data KW - Child KW - Adolescent KW - Male KW - Agenesis of Corpus Callosum KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68545995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychiatry+research&rft.atitle=Corpus+callosum+abnormalities+associated+with+greater+externalizing+behaviors+in+subjects+at+high+risk+for+alcohol+dependence.&rft.au=Venkatasubramanian%2C+Ganesan%3BAnthony%2C+George%3BReddy%2C+Umesh+Srinivasa%3BReddy%2C+Varun+Venkatesh%3BJayakumar%2C+Peruvumba+N%3BBenegal%2C+Vivek&rft.aulast=Venkatasubramanian&rft.aufirst=Ganesan&rft.date=2007-12-15&rft.volume=179&rft.issue=7&rft.spage=4367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intracellular localization of human Ins(1,3,4,5,6)P5 2-kinase. AN - 68541740; 17705785 AB - InsP6 is an intracellular signal with several proposed functions that is synthesized by IP5K [Ins(1,3,4,5,6)P5 2-kinase]. In the present study, we overexpressed EGFP (enhanced green fluorescent protein)-IP5K fusion proteins in NRK (normal rat kidney), COS7 and H1299 cells. The results indicate that there is spatial microheterogeneity in the intracellular localization of IP5K that could also be confirmed for the endogenous enzyme. This may facilitate changes in InsP6 levels at its sites of action. For example, overexpressed IP5K showed a structured organization within the nucleus. The kinase was preferentially localized in euchromatin and nucleoli, and co-localized with mRNA. In the cytoplasm, the overexpressed IP5K showed locally high concentrations in discrete foci. The latter were attributed to stress granules by using mRNA, PABP [poly(A)-binding protein] and TIAR (TIA-1-related protein) as markers. The incidence of stress granules, in which IP5K remained highly concentrated, was further increased by puromycin treatment. Using FRAP (fluorescence recovery after photobleaching) we established that IP5K was actively transported into the nucleus. By site-directed mutagenesis we identified a nuclear import signal and a peptide segment mediating the nuclear export of IP5K. JF - The Biochemical journal AU - Brehm, Maria A AU - Schenk, Tobias M H AU - Zhou, Xuefei AU - Fanick, Werner AU - Lin, Hongying AU - Windhorst, Sabine AU - Nalaskowski, Marcus M AU - Kobras, Mario AU - Shears, Stephen B AU - Mayr, Georg W AD - NIEHS/NIH, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/12/15/ PY - 2007 DA - 2007 Dec 15 SP - 335 EP - 345 VL - 408 IS - 3 KW - DNA Primers KW - 0 KW - RNA, Messenger KW - Phosphotransferases (Alcohol Group Acceptor) KW - EC 2.7.1.- KW - inositol 1,3,4,5,6-pentakisphosphate 2-kinase KW - Index Medicus KW - Animals KW - COS Cells KW - Humans KW - In Situ Hybridization, Fluorescence KW - Amino Acid Sequence KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Chromatography, High Pressure Liquid KW - Mutagenesis, Site-Directed KW - Microscopy, Fluorescence KW - Base Sequence KW - Kinetics KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Subcellular Fractions -- enzymology KW - Phosphotransferases (Alcohol Group Acceptor) -- chemistry KW - Phosphotransferases (Alcohol Group Acceptor) -- metabolism KW - Phosphotransferases (Alcohol Group Acceptor) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68541740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Intracellular+localization+of+human+Ins%281%2C3%2C4%2C5%2C6%29P5+2-kinase.&rft.au=Brehm%2C+Maria+A%3BSchenk%2C+Tobias+M+H%3BZhou%2C+Xuefei%3BFanick%2C+Werner%3BLin%2C+Hongying%3BWindhorst%2C+Sabine%3BNalaskowski%2C+Marcus+M%3BKobras%2C+Mario%3BShears%2C+Stephen+B%3BMayr%2C+Georg+W&rft.aulast=Brehm&rft.aufirst=Maria&rft.date=2007-12-15&rft.volume=408&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-09 N1 - Date created - 2007-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1993 Jan 15;268(2):1032-8 [8419311] Science. 1992 Dec 11;258(5089):1812-5 [1465619] J Chromatogr B Biomed Appl. 1995 Oct 20;672(2):189-98 [8581124] Science. 1996 Oct 25;274(5287):546, 563-7 [8849441] Exp Cell Res. 1997 Oct 10;236(1):346-50 [9344616] Biotechniques. 1999 Apr;26(4):680-2 [10343905] Science. 1999 Jul 2;285(5424):96-100 [10390371] J Biol Chem. 2004 Nov 5;279(45):47222-32 [15322119] Mol Biol Cell. 2004 Dec;15(12):5383-98 [15371533] J Biol Chem. 2004 Dec 3;279(49):51022-32 [15459192] Mol Biol Cell. 2005 Jan;16(1):405-20 [15525674] J Biol Chem. 2005 Jan 14;280(2):1156-64 [15528195] J Biol Chem. 2005 Jan 21;280(3):1911-20 [15531582] J Inorg Biochem. 2005 Mar;99(3):828-40 [15708805] Mol Cell Biol. 2005 Mar;25(6):2463-74 [15743838] J Physiol. 2005 Jul 15;566(Pt 2):295-300 [15860522] J Biol Chem. 2005 Aug 12;280(32):29263-8 [15967797] J Virol. 2005 Sep;79(18):11864-72 [16140763] Science. 2005 Sep 2;309(5740):1534-9 [16141067] Biotechniques. 2005 Dec;39(6):814, 816, 818 passim [16382897] J Biol Chem. 2006 Jan 6;281(1):608-16 [16249182] Cell Mol Life Sci. 2006 Mar;63(5):552-64 [16429326] Biol Chem. 2006 May;387(5):583-93 [16740130] Biochim Biophys Acta. 2006 May-Jun;1761(5-6):552-9 [16781889] Annu Rev Cell Dev Biol. 1999;15:607-60 [10611974] Science. 2000 Mar 17;287(5460):2026-9 [10720331] J Biol Chem. 2000 Aug 11;275(32):24686-92 [10827188] J Biol Chem. 2000 Nov 24;275(47):36575-83 [10960485] J Cell Biol. 2000 Dec 11;151(6):1257-68 [11121440] Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2306-11 [11226235] Cell Signal. 2001 Mar;13(3):151-8 [11282453] RNA. 2001 Dec;7(12):1768-80 [11780633] Curr Biol. 2002 Jan 8;12(1):13-25 [11790299] Biochem J. 2002 Sep 1;366(Pt 2):549-56 [12027805] J Biol Chem. 2002 Aug 30;277(35):31857-62 [12084730] Biochem Soc Trans. 2002 Nov;30(Pt 6):963-9 [12440955] Science. 2003 Jan 3;299(5603):114-6 [12434012] Science. 2003 Jan 3;299(5603):112-4 [12434013] Nat Struct Biol. 2003 Feb;10(2):81-3 [12555081] Trends Cell Biol. 2003 Jun;13(6):319-27 [12791298] Biochem J. 2004 Jan 15;377(Pt 2):265-80 [14567754] Curr Mol Med. 2004 May;4(3):277-90 [15101685] Cell Mol Life Sci. 2004 May;61(10):1143-56 [15141300] Biochem Biophys Res Commun. 2004 Jun 11;318(4):1079-84 [15147984] Nucleic Acids Res. 2004;32(9):2776-84 [15150344] Biochem J. 2004 Aug 15;382(Pt 1):353-62 [15130091] J Biol Chem. 2004 Oct 15;279(42):43403-10 [15297462] Leukemia. 2004 Nov;18(11):1839-49 [15457186] Chromosoma. 1976 Nov 29;58(4):307-24 [137107] Biochem J. 1988 Sep 1;254(2):585-91 [3178774] Biochem J. 1991 Apr 15;275 ( Pt 2):485-99 [1850990] J Biol Chem. 1994 Nov 11;269(45):28393-9 [7961779] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evaluation of harmful algal bloom outreach activities. AN - 733698625; 18463727 AB - With an apparent increase of harmful algal blooms (HABs) worldwide, healthcare providers, public health personnel and coastal managers are struggling to provide scientifically-based appropriately-targeted HAB outreach and education. Since 1998, the Florida Poison Information Center-Miami, with its 24 hour/365 day/year free Aquatic Toxins Hotline (1-888-232-8635) available in several languages, has received over 25,000 HAB-related calls. As part of HAB surveillance, all possible cases of HAB-related illness among callers are reported to the Florida Health Department. This pilot study evaluated an automated call processing menu system that allows callers to access bilingual HAB information, and to speak directly with a trained Poison Information Specialist. The majority (68%) of callers reported satisfaction with the information, and many provided specific suggestions for improvement. This pilot study, the first known evaluation of use and satisfaction with HAB educational outreach materials, demonstrated that the automated system provided useful HAB-related information for the majority of callers, and decreased the routine informational call workload for the Poison Information Specialists, allowing them to focus on callers needing immediate assistance and their healthcare providers. These results will lead to improvement of this valuable HAB outreach, education and surveillance tool. Formal evaluation is recommended for future HAB outreach and educational materials. JF - Marine drugs AU - Fleming, Lora E AU - Jerez, Eva AU - Stephan, Wendy Blair AU - Cassedy, Amy AU - Bean, Judy A AU - Reich, Andrew AU - Kirkpatrick, Barbara AU - Backer, Lorraine AU - Nierenberg, Kate AU - Watkins, Sharon AU - Hollenbeck, Julie AU - Weisman, Richard AD - NSF NIEHS Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33136 USA. lfleming@med.miami.edu Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 208 EP - 219 VL - 5 IS - 4 KW - cyanobacteria KW - Poison Information Centers KW - paralytic shellfish poisoning (PSP) KW - neurotoxic shellfish poisoning (NSP) KW - Solutions to Avoid Red Tide (START) KW - Harmful algal bloom (HAB) KW - ciguatera fish poisoning KW - blue green algae KW - ciguatoxins KW - human health effects KW - Karenia brevis KW - Florida red tide KW - brevetoxins KW - outreach and education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733698625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Administration+of+a+CD25-directed+immunotoxin%2C+LMB-2%2C+to+patients+with+metastatic+melanoma+induces+a+selective+partial+reduction+in+regulatory+T+cells+in+vivo.&rft.au=Powell%2C+Daniel+J%3BFelipe-Silva%2C+Aloisio%3BMerino%2C+Maria+J%3BAhmadzadeh%2C+Mojgan%3BAllen%2C+Tamika%3BLevy%2C+Catherine%3BWhite%2C+Donald+E%3BMavroukakis%2C+Sharon%3BKreitman%2C+Robert+J%3BRosenberg%2C+Steven+A%3BPastan%2C+Ira&rft.aulast=Powell&rft.aufirst=Daniel&rft.date=2007-10-01&rft.volume=179&rft.issue=7&rft.spage=4919&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-17 N1 - Date created - 2008-05-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mar Pollut Bull. 2006;53(10-12):545-60 [16996542] Chest. 2007 Jan;131(1):187-94 [17218574] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The crystal structure of D7r4, a salivary biogenic amine-binding protein from the malaria mosquito Anopheles gambiae. AN - 69050588; 17928288 AB - The D7-related (D7r) proteins of the malaria vector Anopheles gambiae have been shown to bind the biogenic amines serotonin, norepinephrine, and histamine with high affinity. One member of the group (D7r1 or hamadarin) has also been shown to have an anticoagulant/antikinin activity. To understand the mechanistic details of its antihemostatic/anti-inflammatory effects, we have determined the crystal structure of one member of this group, D7r4, along with the structures of ligand complexes with serotonin, tryptamine, histamine, and norepinephrine. The D7 fold consists of an arrangement of eight alpha-helices stabilized by three disulfide bonds. The structure is similar to those of the arthropod odorant-binding proteins, a relationship that had been predicted based on sequence comparisons. Although odorant-binding proteins commonly have six alpha-helices, D7r4 has eight, resulting in significantly different positioning and structure of the ligand binding pocket. The pocket itself is lined by hydrophobic side chains along with polar and charged groups oriented to form hydrogen bonds with the aliphatic amino group and with groups on the aromatic portions of the ligands. These structures, along with accompanying mutagenesis studies, have allowed us to identify critical residues for biogenic amine binding and to predict which members of the large D7 protein family found in blood-feeding nematocerous Diptera will function as biogenic amine-binding proteins. JF - The Journal of biological chemistry AU - Mans, Ben J AU - Calvo, Eric AU - Ribeiro, José M C AU - Andersen, John F AD - Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 36626 EP - 36633 VL - 282 IS - 50 SN - 0021-9258, 0021-9258 KW - Biogenic Amines KW - 0 KW - Disulfides KW - Insect Proteins KW - Salivary Proteins and Peptides KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Arthropod Vectors -- metabolism KW - Animals KW - Protein Structure, Secondary KW - Disulfides -- chemistry KW - Malaria -- transmission KW - Arthropod Vectors -- chemistry KW - Crystallography, X-Ray KW - Hydrogen Bonding KW - Disulfides -- metabolism KW - Binding Sites -- physiology KW - Structure-Activity Relationship KW - Salivary Proteins and Peptides -- chemistry KW - Biogenic Amines -- metabolism KW - Biogenic Amines -- chemistry KW - Salivary Proteins and Peptides -- metabolism KW - Insect Proteins -- chemistry KW - Anopheles gambiae -- chemistry KW - Insect Proteins -- metabolism KW - Anopheles gambiae -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69050588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+crystal+structure+of+D7r4%2C+a+salivary+biogenic+amine-binding+protein+from+the+malaria+mosquito+Anopheles+gambiae.&rft.au=Mans%2C+Ben+J%3BCalvo%2C+Eric%3BRibeiro%2C+Jos%C3%A9+M+C%3BAndersen%2C+John+F&rft.aulast=Mans&rft.aufirst=Ben&rft.date=2007-12-14&rft.volume=282&rft.issue=50&rft.spage=36626&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2QEO; PDB; 2QEB; 2QEV; 2QEH; 2PQL N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metal-catalyzed oxidation of the Werner syndrome protein causes loss of catalytic activities and impaired protein-protein interactions. AN - 69047652; 17911100 AB - Metal-catalyzed oxidation reactions target amino acids in the metal binding pocket of proteins. Such oxidation reactions generally result in either preferential degradation of the protein or accumulation of a catalytically inactive pool of protein with age. Consistently, levels of oxidized proteins have been shown to increase with age. The segmental, progeroid disorder Werner syndrome results from loss of the Werner syndrome protein (WRN). WRN is a member of the RecQ family of DNA helicases and possesses exonuclease and ATP-dependent helicase activities. Furthermore, each of the helicase and exonuclease domains of WRN contains a metal binding pocket. In this report we examined for metal-catalyzed oxidation of WRN in the presence of iron or copper. We found that WRN was oxidized in vitro by iron but not by copper. Iron-mediated oxidation resulted in the inhibition of both WRN helicase and exonuclease activities. Oxidation of WRN also inhibited binding to several known protein partners. In addition, we did not observe degradation of oxidized WRN by the 20 S proteasome in vitro. Finally, exposure of cells to hydrogen peroxide resulted in oxidation of WRN in vivo. Therefore, our results demonstrate that WRN undergoes metal-catalyzed oxidation in the presence of iron, and iron-mediated oxidation of WRN likely results in the accumulation of a catalytically inactive form of the protein, which may contribute to age-related phenotypes. JF - The Journal of biological chemistry AU - Harrigan, Jeanine A AU - Piotrowski, Jason AU - Di Noto, Luca AU - Levine, Rodney L AU - Bohr, Vilhelm A AD - Laboratory of Molecular Gerontology, NIA, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/12/14/ PY - 2007 DA - 2007 Dec 14 SP - 36403 EP - 36411 VL - 282 IS - 50 SN - 0021-9258, 0021-9258 KW - Oxidants KW - 0 KW - Recombinant Proteins KW - Copper KW - 789U1901C5 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Iron KW - E1UOL152H7 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Index Medicus KW - Oxidants -- pharmacology KW - Oxidation-Reduction -- drug effects KW - HeLa Cells KW - Humans KW - Copper -- metabolism KW - Hydrogen Peroxide -- pharmacology KW - Binding Sites -- physiology KW - Copper -- chemistry KW - Phenotype KW - Proteasome Endopeptidase Complex -- metabolism KW - Recombinant Proteins -- metabolism KW - Protein Structure, Tertiary -- physiology KW - Recombinant Proteins -- chemistry KW - Catalysis KW - Werner Syndrome -- enzymology KW - RecQ Helicases -- metabolism KW - Iron -- chemistry KW - RecQ Helicases -- chemistry KW - Iron -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Metal-catalyzed+oxidation+of+the+Werner+syndrome+protein+causes+loss+of+catalytic+activities+and+impaired+protein-protein+interactions.&rft.au=Harrigan%2C+Jeanine+A%3BPiotrowski%2C+Jason%3BDi+Noto%2C+Luca%3BLevine%2C+Rodney+L%3BBohr%2C+Vilhelm+A&rft.aulast=Harrigan&rft.aufirst=Jeanine&rft.date=2007-12-14&rft.volume=282&rft.issue=50&rft.spage=36403&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges. AN - 69056043; 18074021 AB - DNA helicases are ubiquitous enzymes that unwind DNA in an ATP-dependent and directionally specific manner. Unwinding of double-stranded DNA is essential for the processes of DNA repair, recombination, transcription, and DNA replication. Five human DNA helicases sharing sequence similarity with the E. coli RecQ helicase have been identified. Three of the human RecQ helicases are implicated in hereditary diseases (Bloom syndrome, Werner syndrome, and Rothmund-Thomson syndrome) which display clinical symptoms of premature aging and cancer. RECQ1 helicase is the most highly expressed of the human RecQ helicases; however, a genetic disease has yet not been linked to mutations in the RECQ1 gene, and the biological functions of human RECQ1 in cellular DNA metabolism are not known. In this study, we report that RECQ1 becomes phosphorylated upon DNA damage and forms irradiation-induced nuclear foci that associate with chromatin in human cells. Depletion of RECQ1 renders human cells sensitive to DNA damage induced by ionizing radiation or the topoisomerase inhibitor camptothecin, and results in spontaneous gamma-H2AX foci and elevated sister chromatid exchanges, indicating aberrant repair of DNA breaks. Consistent with a role in homologous recombinational repair, endogenous RECQ1 is associated with the strand exchange protein Rad51 and the two proteins directly interact with high affinity. Collectively, these results provide the first evidence for a role of human RECQ1 in the response to DNA damage and chromosomal stability maintenance and point to the vital importance of RECQ1 in genome homeostasis. JF - PloS one AU - Sharma, Sudha AU - Brosh, Robert M AD - Laboratory of Molecular Gerontology, Department of Health and Human Services, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America. Y1 - 2007/12/12/ PY - 2007 DA - 2007 Dec 12 SP - 1 VL - 2 IS - 12 KW - Mutagens KW - 0 KW - RNA, Small Interfering KW - RecQ Helicases KW - EC 3.6.4.12 KW - Index Medicus KW - Base Sequence KW - HeLa Cells KW - Humans KW - Sister Chromatid Exchange KW - DNA Damage KW - RecQ Helicases -- metabolism KW - Oxidative Stress KW - RecQ Helicases -- genetics KW - Mutagens -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69056043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Human+RECQ1+is+a+DNA+damage+responsive+protein+required+for+genotoxic+stress+resistance+and+suppression+of+sister+chromatid+exchanges.&rft.au=Sharma%2C+Sudha%3BBrosh%2C+Robert+M&rft.aulast=Sharma&rft.aufirst=Sudha&rft.date=2007-12-12&rft.volume=2&rft.issue=12&rft.spage=e1297&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2000 Aug 4;275(31):23500-8 [10825162] Nucleic Acids Res. 2004;32(7):2158-70 [15096578] Mol Cell Biol. 2001 Jan;21(1):281-8 [11113202] J Cell Biol. 2001 Apr 16;153(2):367-80 [11309417] J Biol Chem. 2001 Jun 1;276(22):19375-81 [11278509] Mutat Res. 2002 Nov 30;509(1-2):49-78 [12427531] Mol Biol Cell. 2002 Nov;13(11):4100-9 [12429849] Oncogene. 2002 Dec 16;21(58):9008-21 [12483516] J Biol Chem. 2003 Jan 17;278(3):1424-32 [12419808] Curr Genet. 2003 Jan;42(4):220-7 [12589473] Science. 1999 Dec 17;286(5448):2342-4 [10600745] Carcinogenesis. 2000 Mar;21(3):485-95 [10688869] Cancer Res. 2000 Mar 1;60(5):1162-7 [10728666] Hum Mol Genet. 2000 Jul 22;9(12):1805-11 [10915769] EMBO J. 2003 Mar 3;22(5):1210-22 [12606585] Nat Rev Cancer. 2003 Mar;3(3):169-78 [12612652] Mol Cell Biol. 2003 May;23(10):3527-35 [12724411] Mol Cell Biol. 2003 May;23(10):3692-705 [12724426] Nature. 2003 May 15;423(6937):305-9 [12748644] Nature. 2003 May 15;423(6937):309-12 [12748645] Genes Dev. 2003 Aug 15;17(16):2021-35 [12893777] Biochem J. 2003 Sep 15;374(Pt 3):577-606 [12803543] Nature. 2003 Dec 18;426(6968):870-4 [14685245] Mol Cell Biol. 2004 Feb;24(3):1279-91 [14729972] Curr Genet. 2004 Feb;45(1):37-44 [14595518] Cancer Res. 2004 Mar 1;64(5):1834-42 [14996747] J Cell Biol. 2004 Sep 13;166(6):801-13 [15364958] Nature. 1974 Sep 13;251(5471):156-8 [4138930] Nucleic Acids Res. 1983 Mar 11;11(5):1475-89 [6828386] Cancer Genet Cytogenet. 1993 Oct 15;70(2):85-93 [8242603] J Biol Chem. 1994 Nov 25;269(47):29838-45 [7961977] Nucleic Acids Res. 1994 Nov 11;22(22):4566-73 [7527136] Genomics. 1995 Apr 10;26(3):595-8 [7607686] Cell. 1997 Feb 7;88(3):323-31 [9039259] Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6887-92 [9618508] Exp Cell Res. 1998 Aug 1;242(2):487-94 [9683536] Nature. 2005 Jan 6;433(7021):77-83 [15635413] Blood. 2005 Feb 1;105(3):1003-9 [15454491] Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55 [15688066] Genetics. 2005 Feb;169(2):563-74 [15489516] Mol Cell Biol. 2005 May;25(9):3431-42 [15831450] EMBO J. 2005 Apr 6;24(7):1465-76 [15775963] Cancer Cell. 2005 Jun;7(6):505-12 [15950900] EMBO J. 2005 Jul 20;24(14):2679-87 [15990871] J Biol Chem. 2005 Jul 29;280(30):28085-94 [15886194] J Biol Chem. 2005 Jul 29;280(30):28072-84 [15899892] J Cell Sci. 2005 Sep 15;118(Pt 18):4261-9 [16141230] Mol Cell Biol. 2005 Oct;25(20):8925-37 [16199871] Nucleic Acids Res. 2005;33(19):6251-7 [16260474] Genetics. 2006 Jan;172(1):113-25 [16219790] Cancer Res. 2006 Mar 15;66(6):3323-30 [16540687] J Clin Oncol. 2006 Apr 10;24(11):1720-8 [16520463] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5875-80 [16595622] Science. 2006 Jul 21;313(5785):363-7 [16778019] Biochem J. 2006 Sep 15;398(3):319-37 [16925525] Nat Rev Cancer. 2006 Oct;6(10):789-802 [16990856] Mol Cell Biol. 2007 Mar;27(5):1784-94 [17158923] PLoS Biol. 2007 Feb;5(2):e20 [17227144] J Cell Sci. 2007 Mar 1;120(Pt 5):713-21 [17314245] Bioessays. 2007 Apr;29(4):382-5 [17373697] Nat Struct Mol Biol. 2007 Jul;14(7):677-9 [17603497] Oncogene. 2000 Sep 28;19(41):4764-72 [11032027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of kappa opioid agonists alone and in combination with cocaine on heart rate and blood pressure in conscious squirrel monkeys. AN - 68423024; 17707792 AB - As kappa agonists have been proposed as treatments for cocaine abuse, the cardiovascular effects of the kappa opioid receptor agonists ethylketocyclazocine (EKC) and enadoline were investigated in conscious squirrel monkeys. Both EKC and enadoline increased heart rate with little effect on blood pressure. This effect appeared to be specific for kappa receptors as the mu opioid agonist morphine did not mimic the effects of the kappa agonists. The opioid antagonist naltrexone, at a dose of 1.0 mg/kg, blocked the effect of EKC. An action at both central and peripheral receptors may be responsible for the heart rate increase following kappa agonist treatment. The ganglionic blocker chlorisondamine partially antagonized the effect of EKC on heart rate, suggesting central involvement, while the peripherally-acting agonist ICI 204,448 ((+/-)-1-[2,3- (Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride) also increased heart rate, supporting a peripheral site of action. When given in combination with cocaine, EKC produced effects that were sub-additive, suggesting that the kappa agonists may be used safely as cocaine abuse treatments. JF - European journal of pharmacology AU - Schindler, Charles W AU - Graczyk, Zofi AU - Gilman, Joanne P AU - Negus, S Stevens AU - Bergman, Jack AU - Mello, Nancy K AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Branch, DHHS/NIH/NIDA Intramural Research Program, Baltimore MD (CWS, ZG, JPG, SRG), United States. cschindl@helix.nih.gov Y1 - 2007/12/08/ PY - 2007 DA - 2007 Dec 08 SP - 107 EP - 113 VL - 576 IS - 1-3 SN - 0014-2999, 0014-2999 KW - Benzofurans KW - 0 KW - Pyrrolidines KW - Receptors, Opioid, kappa KW - Ethylketocyclazocine KW - 58640-84-9 KW - Cocaine KW - I5Y540LHVR KW - enadoline KW - KJL283326C KW - Index Medicus KW - Saimiri KW - Animals KW - Drug Interactions KW - Cocaine-Related Disorders -- drug therapy KW - Cocaine-Related Disorders -- physiopathology KW - Blood Pressure -- drug effects KW - Male KW - Heart Rate -- drug effects KW - Ethylketocyclazocine -- pharmacology KW - Receptors, Opioid, kappa -- agonists KW - Pyrrolidines -- pharmacology KW - Receptors, Opioid, kappa -- physiology KW - Cocaine -- pharmacology KW - Benzofurans -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68423024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+pharmacology&rft.atitle=Effects+of+kappa+opioid+agonists+alone+and+in+combination+with+cocaine+on+heart+rate+and+blood+pressure+in+conscious+squirrel+monkeys.&rft.au=Schindler%2C+Charles+W%3BGraczyk%2C+Zofi%3BGilman%2C+Joanne+P%3BNegus%2C+S+Stevens%3BBergman%2C+Jack%3BMello%2C+Nancy+K%3BGoldberg%2C+Steven+R&rft.aulast=Schindler&rft.aufirst=Charles&rft.date=2007-12-08&rft.volume=576&rft.issue=1-3&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=European+journal+of+pharmacology&rft.issn=00142999&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2007-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res. 1991 Nov 22;565(1):67-77 [1685349] Life Sci. 1993;52(7):599-611 [8381501] Pharmacol Res. 1993 Apr;27(3):233-9 [8100996] Br J Pharmacol. 1994 Mar;111(3):843-51 [8019761] J Pharmacol Exp Ther. 1996 Jul;278(1):232-42 [8764356] Biol Signals. 1995 May-Jun;4(3):174-8 [8750944] Neurochem Res. 1996 Nov;21(11):1369-73 [8947927] Can J Physiol Pharmacol. 1998 Mar;76(3):252-8 [9673788] J Exp Anal Behav. 1963 Apr;6:297-8 [13952017] Neuropsychopharmacology. 2005 Mar;30(3):618-32 [15602503] Neuropeptides. 1983 Jan;3(3):193-212 [16229162] Br J Pharmacol. 2006 Jul;148(6):795-806 [16751796] Ann N Y Acad Sci. 2000;909:104-32 [10911926] J Pharmacol Exp Ther. 2001 Apr;297(1):215-23 [11259547] Mol Pharmacol. 2002 Jan;61(1):73-84 [11752208] Am J Cardiol. 2002 Oct 1;90(7):810-1 [12356410] Neuropsychopharmacology. 2003 Jun;28(6):1125-39 [12637953] Eur J Pharmacol. 2004 Feb 6;485(1-3):119-25 [14757131] Br J Pharmacol. 2004 Apr;141(8):1331-4 [15051626] Am J Physiol. 1969 Jul;217(1):24-9 [4977636] Neuropharmacology. 1982 Sep;21(9):923-8 [6128693] Pharmacol Biochem Behav. 1983 Oct;19(4):711-3 [6359177] Peptides. 1983 Sep-Oct;4(5):621-5 [6318199] Eur J Pharmacol. 1983 Dec 9;96(1-2):165-9 [6319158] Prog Neuropsychopharmacol Biol Psychiatry. 1983;7(4-6):577-84 [6686694] Pharmacol Rev. 1983 Dec;35(4):283-323 [6144112] Naunyn Schmiedebergs Arch Pharmacol. 1984 Nov;328(1):20-3 [6096725] Biochem Biophys Res Commun. 1985 Feb 28;127(1):120-8 [3977917] Eur J Pharmacol. 1985 May 8;111(2):263-6 [2410282] Can J Physiol Pharmacol. 1986 Jun;64(6):729-36 [3756625] J Cardiovasc Pharmacol. 1986 Sep-Oct;8(5):950-6 [2429096] Jpn J Pharmacol. 1987 Sep;45(1):125-8 [2890782] Trends Neurosci. 1988 Jul;11(7):308-14 [2465635] Pharmacol Biochem Behav. 1989 Oct;34(2):405-11 [2695944] Br J Pharmacol. 1990 Sep;101(1):183-9 [2178014] J Mol Cell Cardiol. 1990 Oct;22(10):1167-75 [1965662] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of genetic mutations and chemical exposures on Caenorhabditis elegans feeding: evaluation of a novel, high-throughput screening assay. AN - 69047921; 18060055 AB - Government agencies have defined a need to reduce, refine or replace current mammalian-based bioassays with testing methods that use alternative species. Invertebrate species, such as Caenorhabditis elegans, provide an attractive option because of their short life cycles, inexpensive maintenance, and high degree of evolutionary conservation with higher eukaryotes. The C. elegans pharynx is a favorable model for studying neuromuscular function, and the effects of chemicals on neuromuscular activity, i.e., feeding. Current feeding methodologies, however, are labor intensive and only semi-quantitative. Here a high-throughput assay is described that uses flow cytometry to measure C. elegans feeding by determining the size and intestinal fluorescence of hundreds of nematodes after exposure to fluorescent-labeled microspheres. This assay was validated by quantifying fluorescence in feeding-defective C. elegans (eat mutants), and by exposing wild-type nematodes to the neuroactive compounds, serotonin and arecoline. The eat mutations previously determined to cause slow pumping rates exhibited the lowest feeding levels with our assay. Concentration-dependent increases in feeding levels after serotonin exposures were dependent on food availability, while feeding levels decreased in arecoline-exposed nematodes regardless of the presence of food. The effects of the environmental contaminants, cadmium chloride and chlorpyrifos, on wild-type C. elegans feeding were then used to demonstrate an application of the feeding assay. Cadmium exposures above 200 microM led to a sharp drop in feeding levels. Feeding of chlorpyrifos-exposed nematodes decreased in a concentration-dependent fashion with an EC(50) of 2 microM. The C. elegans fluorescence microsphere feeding assay is a rapid, reliable method for the assessment of neurotoxic effects of pharmaceutical drugs, industrial chemicals or environmental agents. This assay may also be applicable to large scale genetic or RNAi screens used to identify genes that are necessary for the development or function of the pharynx or other neuromuscular systems. JF - PloS one AU - Boyd, Windy A AU - McBride, Sandra J AU - Freedman, Jonathan H AD - Laboratory of Molecular Toxicology, National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 SP - 1 VL - 2 IS - 12 KW - Index Medicus KW - Animals KW - Drug Evaluation, Preclinical KW - Caenorhabditis elegans -- drug effects KW - Caenorhabditis elegans -- physiology KW - Mutation KW - Feeding Behavior -- drug effects KW - Caenorhabditis elegans -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69047921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PloS+one&rft.atitle=Effects+of+genetic+mutations+and+chemical+exposures+on+Caenorhabditis+elegans+feeding%3A+evaluation+of+a+novel%2C+high-throughput+screening+assay.&rft.au=Boyd%2C+Windy+A%3BMcBride%2C+Sandra+J%3BFreedman%2C+Jonathan+H&rft.aulast=Boyd&rft.aufirst=Windy&rft.date=2007-12-05&rft.volume=2&rft.issue=12&rft.spage=e1259&rft.isbn=&rft.btitle=&rft.title=PloS+one&rft.issn=1932-6203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-08 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Biotechnol. 2001 Feb;19(2):153-6 [11175730] J Inorg Biochem. 2000 Apr;79(1-4):241-4 [10830873] Environ Toxicol Chem. 2001 Apr;20(4):833-8 [11345460] Int Rev Cytol. 2001;209:207-39 [11580201] J Exp Biol. 2003 Jan;206(Pt 2):223-31 [12477893] J Exp Biol. 2003 Jul;206(Pt 14):2441-57 [12796460] Free Radic Biol Med. 2003 Sep 15;35(6):558-65 [12957648] Environ Toxicol Chem. 2003 Dec;22(12):3049-55 [14713049] Toxicol Appl Pharmacol. 2004 Feb 1;194(3):248-56 [14761681] Nat Immunol. 2004 May;5(5):488-94 [15048112] Proc Natl Acad Sci U S A. 2004 May 25;101(21):8084-9 [15141086] Environ Toxicol Chem. 2004 May;23(5):1235-40 [15180374] Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11773-8 [15280551] Genetics. 1974 May;77(1):71-94 [4366476] Can J Zool. 1975 Jul;53(7):894-903 [1079747] Toxicol Appl Pharmacol. 1977 Sep;41(3):667-80 [918994] Science. 1982 May 28;216(4549):1012-4 [6805073] Toxicol Appl Pharmacol. 1982 May;63(3):330-7 [7101297] Mech Ageing Dev. 1983 Jul-Aug;22(3-4):279-86 [6632998] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] J Exp Zool. 1990 Mar;253(3):263-70 [2181052] Genetics. 1993 Apr;133(4):897-917 [8462849] Genetics. 1993 Jun;134(2):455-64 [8325482] Neuron. 1994 Mar;12(3):483-95 [8155316] J Neurosci. 1995 Dec;15(12):8408-18 [8613772] Rev Environ Contam Toxicol. 1995;144:1-93 [8599033] Genetics. 1995 Dec;141(4):1365-82 [8601480] Arch Environ Contam Toxicol. 1997 Jan;32(1):110-4 [9002442] J Exp Zool. 1999 Jul 1;284(2):147-57 [10404644] J Biochem Mol Toxicol. 2005;19(2):87-95 [15849720] Nat Genet. 2005 Aug;37(8):894-8 [16041374] Cell Metab. 2006 Apr;3(4):237-45 [16581001] Dev Biol. 2006 Aug 15;296(2):409-20 [16828468] BMC Dev Biol. 2006;6:39 [16884547] Regul Toxicol Pharmacol. 2006 Oct;46(1):18-22 [16876299] Nat Methods. 2006 Sep;3(9):662-3 [16967553] Methods Mol Biol. 2006;351:275-86 [16988441] Anal Biochem. 2006 Dec 1;359(1):1-17 [16942745] Genetics. 2000 Feb;154(2):635-46 [10655217] Hum Mol Genet. 2000 Apr 12;9(6):869-77 [10767309] Genome Biol. 2001;2(2):REVIEWS1005 [11182891] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunocompetent syngeneic cotton rat tumor models for the assessment of replication-competent oncolytic adenovirus. AN - 68485282; 17727912 AB - Oncolytic adenoviruses as a treatment for cancer have demonstrated limited clinical activity. Contributing to this may be the relevance of preclinical animal models used to study these agents. Syngeneic mouse tumor models are generally non-permissive for adenoviral replication, whereas human tumor xenograft models exhibit attenuated immune responses to the vector. The cotton rat (Sigmodon hispidus) is susceptible to human adenovirus infection, permissive for viral replication and exhibits similar inflammatory pathology to humans with adenovirus replicating in the lungs, respiratory passages and cornea. We evaluated three transplantable tumorigenic cotton rat cell lines, CCRT, LCRT and VCRT as models for the study of oncolytic adenoviruses. All three cells lines were readily infected with adenovirus type-5-based vectors and exhibited high levels of transgene expression. The cell lines supported viral replication demonstrated by the induction of cytopathogenic effect (CPE) in tissue culture, increase in virus particle numbers and assembly of virions seen on transmission electron microscopy. In vivo, LCRT and VCRT tumors demonstrated delayed growth after injection with replicating adenovirus. No in vivo antitumor activity was seen in CCRT tumors despite in vitro oncolysis. Adenovirus was also rapidly cleared from the CCRT tumors compared to LCRT and VCRT tumors. The effect observed with the different cotton rat tumor cell lines mimics the variable results of human clinical trials highlighting the potential relevance of this model for assessing the activity and toxicity of oncolytic adenoviruses. JF - Virology AU - Steel, Jason C AU - Morrison, Brian J AU - Mannan, Poonam AU - Abu-Asab, Mones S AU - Wildner, Oliver AU - Miles, Brian K AU - Yim, Kevin C AU - Ramanan, Vijay AU - Prince, Gregory A AU - Morris, John C AD - Cancer Gene Therapy Section, Metabolism Branch, Center for Cancer Research, National Cancer Institute, Mark O. Hatfield Clinical Research Center, Room 4-5330, 10 Center Drive, Bethesda, MD 20892-1457, National Institutes of Health, Maryland, USA. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 SP - 131 EP - 142 VL - 369 IS - 1 SN - 0042-6822, 0042-6822 KW - Index Medicus KW - Rats KW - Virion -- ultrastructure KW - Microscopy, Electron, Transmission KW - Animals KW - Viral Plaque Assay KW - Transplantation, Isogeneic KW - Cytopathogenic Effect, Viral KW - Cell Line, Tumor KW - Sigmodontinae KW - Oncolytic Virotherapy -- methods KW - Neoplasms -- virology KW - Adenoviridae -- growth & development KW - Disease Models, Animal KW - Neoplasms -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68485282?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Immunocompetent+syngeneic+cotton+rat+tumor+models+for+the+assessment+of+replication-competent+oncolytic+adenovirus.&rft.au=Steel%2C+Jason+C%3BMorrison%2C+Brian+J%3BMannan%2C+Poonam%3BAbu-Asab%2C+Mones+S%3BWildner%2C+Oliver%3BMiles%2C+Brian+K%3BYim%2C+Kevin+C%3BRamanan%2C+Vijay%3BPrince%2C+Gregory+A%3BMorris%2C+John+C&rft.aulast=Steel&rft.aufirst=Jason&rft.date=2007-12-05&rft.volume=47&rft.issue=10&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-21 N1 - Date created - 2007-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Hum Gene Ther. 2001 Jan 1;12(1):25-34 [11177539] J Virol. 2006 Apr;80(7):3549-58 [16537623] Mol Ther. 2001 May;3(5 Pt 1):697-707 [11356075] Hum Gene Ther. 2001 Aug 10;12(12):1591-3 [11529247] Cancer Res. 2001 Oct 15;61(20):7464-72 [11606381] Expert Opin Biol Ther. 2001 May;1(3):525-38 [11727523] Hum Gene Ther. 2002 Jan 1;13(1):101-12 [11779414] Cancer Gene Ther. 2002 Mar;9(3):254-9 [11896441] Cancer Res. 2002 Sep 1;62(17):4968-76 [12208748] Lab Anim. 2002 Oct;36(4):357-72 [12396279] Mol Ther. 2003 Sep;8(3):412-24 [12946314] Mol Ther. 2006 Jul;14(1):107-17 [16690359] Mol Ther. 2007 May;15(5):1016-23 [17375076] Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S157-60 [14508094] Hum Gene Ther. 2003 Dec 10;14(18):1715-26 [14670123] J Natl Cancer Inst. 1968 Feb;40(2):389-405 [5638610] J Infect Dis. 1984 Jul;150(1):92-7 [6086773] Clin Exp Metastasis. 1983 Oct-Dec;1(4):373-80 [6546207] Proc Natl Acad Sci U S A. 1990 Aug;87(16):6191-5 [2166948] Arch Ophthalmol. 1992 Aug;110(8):1167-70 [1323254] J Virol. 1993 Jan;67(1):101-11 [8380066] Proc Natl Acad Sci U S A. 1994 May 10;91(10):4407-11 [8183921] Mol Biotechnol. 1995 Jun;3(3):207-20 [7552690] Science. 1996 Oct 18;274(5286):373-6 [8832876] Science. 1997 Feb 28;275(5304):1320-3 [9036860] Gene Ther. 1997 Apr;4(4):275-9 [9176511] Hum Gene Ther. 1998 Feb 10;9(3):367-78 [9508054] Cancer Gene Ther. 1998 Nov-Dec;5(6):365-70 [9917091] J Immunol. 1999 Jul 1;163(1):184-93 [10384115] Proc Soc Exp Biol Med. 1953 Dec;84(3):570-3 [13134217] Cancer Res. 2004 Nov 1;64(21):8022-8 [15520211] Cancer. 1956 Nov-Dec;9(6):1211-8 [13383455] J Lab Clin Med. 1956 Apr;47(4):573-82 [13307092] J Virol. 2005 Jan;79(2):1308-11 [15613357] Hum Gene Ther. 2005 Jan;16(1):139-46 [15703497] Cancer Res. 2006 Feb 1;66(3):1270-6 [16452178] J Clin Oncol. 2001 Jan 15;19(2):289-98 [11208818] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Family History of Lung Cancer and Lung Cancer Risk among Finnish Male Smokers. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40818217; 4802126 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Kosti, O AU - Gaudet, M M AU - Jiyoung, A AU - Graubard, B I AU - Weinstein, S J AU - Ashby, J AU - Virtamo, J AU - Bergen, A W AU - Albanes, D Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Lung cancer KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40818217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Family+History+of+Lung+Cancer+and+Lung+Cancer+Risk+among+Finnish+Male+Smokers.&rft.au=Kosti%2C+O%3BGaudet%2C+M+M%3BJiyoung%2C+A%3BGraubard%2C+B+I%3BWeinstein%2C+S+J%3BAshby%2C+J%3BVirtamo%2C+J%3BBergen%2C+A+W%3BAlbanes%2C+D&rft.aulast=Kosti&rft.aufirst=O&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Physical Activity on Biomarkers for the Prevention of Breast Cancer: A Twelve-Week Intervention. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817804; 4802118 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Micheli, A AU - Korde, L AU - Venzon, D AU - Eng-Wong, J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Bioindicators KW - Physical activity KW - Prevention KW - Intervention KW - Breast cancer KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Effects+of+Physical+Activity+on+Biomarkers+for+the+Prevention+of+Breast+Cancer%3A+A+Twelve-Week+Intervention.&rft.au=Micheli%2C+A%3BKorde%2C+L%3BVenzon%2C+D%3BEng-Wong%2C+J&rft.aulast=Micheli&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictors of Non-Compliance with Baseline Sigmoidoscopy in the PLCO Screening Trial. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817695; 4801955 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Doria-Rose, V P AU - Schoen, R E AU - Weissfeld, J L AU - Pinsky, P F AU - Hayes, R B AU - Riley, T AU - Laiyemo, A AU - Black, A AU - Marcus, P M Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Sigmoidoscopy KW - Phospholipase C KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Predictors+of+Non-Compliance+with+Baseline+Sigmoidoscopy+in+the+PLCO+Screening+Trial.&rft.au=Doria-Rose%2C+V+P%3BSchoen%2C+R+E%3BWeissfeld%2C+J+L%3BPinsky%2C+P+F%3BHayes%2C+R+B%3BRiley%2C+T%3BLaiyemo%2C+A%3BBlack%2C+A%3BMarcus%2C+P+M&rft.aulast=Doria-Rose&rft.aufirst=V&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapamycin Prevents Tobacco-carcinogen Induced Lung Tumorigenesis and Selectively Reduces Lung-associated Foxp3 Positive Cells. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40817672; 4802060 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Granville, C A AU - Mariotti, J AU - Kawabata, S AU - Foley, J AU - Hollander, M Christine AU - Han, W AU - Balogh, A AU - Memmott, R AU - LoPiccolo, J AU - Liewehr, D AU - Steinberg, S AU - Fowler, D H AU - Dennis, P A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Lung KW - Rapamycin KW - Tumorigenesis KW - Foxp3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40817672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Effectiveness+of+methylphenidate+in+the+10-month+continuation+phase+of+the+Preschoolers+with+Attention-Deficit%2FHyperactivity+Disorder+Treatment+Study+%28PATS%29.&rft.au=Vitiello%2C+Benedetto%3BAbikoff%2C+Howard+B%3BChuang%2C+Shirley+Z%3BKollins%2C+Scott+H%3BMcCracken%2C+James+T%3BRiddle%2C+Mark+A%3BSwanson%2C+James+M%3BWigal%2C+Tim%3BMcGough%2C+James+J%3BGhuman%2C+Jaswinder+K%3BWigal%2C+Sharon+B%3BSkrobala%2C+Anne+M%3BDavies%2C+Mark%3BPosner%2C+Kelly%3BCunningham%2C+Charles%3BGreenhill%2C+Laurence+L&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-10-01&rft.volume=17&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Index-based Dietary Patterns and Risk of Colorectal Cancer: The NIH-AARP Diet and Health Study. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40816321; 4802097 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Reedy, J AU - Mitrou, P AU - Krebs-Smith, S M AU - Wirfalt, E AU - Flood, A AU - Kipnis, V AU - Leitzmann, M AU - Mouw, T AU - Hollenbeck, A AU - Schatzkin, A AU - Subar, A F Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Colorectal cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40816321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Index-based+Dietary+Patterns+and+Risk+of+Colorectal+Cancer%3A+The+NIH-AARP+Diet+and+Health+Study.&rft.au=Reedy%2C+J%3BMitrou%2C+P%3BKrebs-Smith%2C+S+M%3BWirfalt%2C+E%3BFlood%2C+A%3BKipnis%2C+V%3BLeitzmann%2C+M%3BMouw%2C+T%3BHollenbeck%2C+A%3BSchatzkin%2C+A%3BSubar%2C+A+F&rft.aulast=Reedy&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Association between Variant Alleles of GSTM1 and GSTT1 and Lung Cancer Risk: A Nested Case-control Study in Washington County, Maryland. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40816201; 4802065 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Lam, T K AU - Ruczinski, I AU - Helzlsouer, K AU - Shugart, Y AU - Li, K E AU - Hoffman, S C AU - Alberg, A J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - USA, Rhode Island, Washington Cty. KW - USA, Maryland KW - Lung cancer KW - GSTM1 protein KW - GSTT1 protein KW - Allelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40816201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=The+Association+between+Variant+Alleles+of+GSTM1+and+GSTT1+and+Lung+Cancer+Risk%3A+A+Nested+Case-control+Study+in+Washington+County%2C+Maryland.&rft.au=Lam%2C+T+K%3BRuczinski%2C+I%3BHelzlsouer%2C+K%3BShugart%2C+Y%3BLi%2C+K+E%3BHoffman%2C+S+C%3BAlberg%2C+A+J&rft.aulast=Lam&rft.aufirst=T&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial Variation in Steroid Hormone and Growth Factor Concentration: US African-American and White Female Newborns. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815836; 4801944 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Agurs-Collins, T D AU - Rohrmann, S AU - Sutcliffe, C G AU - Bienstock, J L AU - Bradwin, G AU - Rifai, N AU - Pollak, M N AU - Platz, E A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Africa KW - Growth factors KW - Steroid hormones KW - Neonates KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Racial+Variation+in+Steroid+Hormone+and+Growth+Factor+Concentration%3A+US+African-American+and+White+Female+Newborns.&rft.au=Agurs-Collins%2C+T+D%3BRohrmann%2C+S%3BSutcliffe%2C+C+G%3BBienstock%2C+J+L%3BBradwin%2C+G%3BRifai%2C+N%3BPollak%2C+M+N%3BPlatz%2C+E+A&rft.aulast=Agurs-Collins&rft.aufirst=T&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preventive Effects of the RXR Agonists Targretin and UAB-30 in Transgenic Mouse Models of Estrogen Receptor (ER) Negative Mammary Cancer. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815329; 4802054 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Lubet, R A AU - Ruppert, J AU - Muccio, D D AU - You, M AU - Brouilette, W J AU - Atigadda, R AU - Steele, V E AU - Juliana, M AU - Grubbs, C J Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Estrogen receptors KW - Animal models KW - Retinoid X receptors KW - Transgenic mice KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Preventive+Effects+of+the+RXR+Agonists+Targretin+and+UAB-30+in+Transgenic+Mouse+Models+of+Estrogen+Receptor+%28ER%29+Negative+Mammary+Cancer.&rft.au=Lubet%2C+R+A%3BRuppert%2C+J%3BMuccio%2C+D+D%3BYou%2C+M%3BBrouilette%2C+W+J%3BAtigadda%2C+R%3BSteele%2C+V+E%3BJuliana%2C+M%3BGrubbs%2C+C+J&rft.aulast=Lubet&rft.aufirst=R&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation-associated Genes as Potential Molecular Targets for Dietary Prevention of Colon Carcinogenesis in an AOMDSS Mouse Model. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815291; 4802037 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Bobe, G AU - Lee, G C AU - Mentor-Marcel, R A AU - Kim, Y S AU - Young, M R AU - Colburn, N H Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Prevention KW - Diets KW - Carcinogenesis KW - Colon KW - Animal models KW - Molecular modelling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Inflammation-associated+Genes+as+Potential+Molecular+Targets+for+Dietary+Prevention+of+Colon+Carcinogenesis+in+an+AOMDSS+Mouse+Model.&rft.au=Bobe%2C+G%3BLee%2C+G+C%3BMentor-Marcel%2C+R+A%3BKim%2C+Y+S%3BYoung%2C+M+R%3BColburn%2C+N+H&rft.aulast=Bobe&rft.aufirst=G&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Selective Small Molecule NF-kB Inhibitor from a Highthroughput Cell Based Assay for "AP-1 Hits". T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815283; 4802036 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Kang, M AU - Henrich, C J AU - Bokesch, H R AU - Gustafson, K R AU - Young, M R AU - Colburn, N H Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - NF-B protein KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=A+Selective+Small+Molecule+NF-kB+Inhibitor+from+a+Highthroughput+Cell+Based+Assay+for+%22AP-1+Hits%22.&rft.au=Kang%2C+M%3BHenrich%2C+C+J%3BBokesch%2C+H+R%3BGustafson%2C+K+R%3BYoung%2C+M+R%3BColburn%2C+N+H&rft.aulast=Kang&rft.aufirst=M&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Translational Targets of Tumor Suppressor PDCD4 through Analysis of Polysomal mRNA Recruitment. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40815255; 4801993 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Santhanam, A N AU - Jansen, A P AU - Colburn, N Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Recruitment KW - Translation KW - MRNA KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40815255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Identification+of+Translational+Targets+of+Tumor+Suppressor+PDCD4+through+Analysis+of+Polysomal+mRNA+Recruitment.&rft.au=Santhanam%2C+A+N%3BJansen%2C+A+P%3BColburn%2C+N&rft.aulast=Santhanam&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Body Mass Index and Mortality in a Lean Chinese Population. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814653; 4802137 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Zhang, Y AU - Dawsey, S M AU - Taylor, P R AU - Qiao, Y AU - Abnet, C C Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Mortality KW - Body mass KW - Body mass index KW - Population structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Body+Mass+Index+and+Mortality+in+a+Lean+Chinese+Population.&rft.au=Zhang%2C+Y%3BDawsey%2C+S+M%3BTaylor%2C+P+R%3BQiao%2C+Y%3BAbnet%2C+C+C&rft.aulast=Zhang&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender-specific Effects of Dietary Carotenoid Intake on Lung Cancer Risk. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814321; 4802111 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Watters, J AU - Mahabir, S AU - Dong, Y AU - Spitz, M AU - Forman, M Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Lung cancer KW - Carotenoids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Gender-specific+Effects+of+Dietary+Carotenoid+Intake+on+Lung+Cancer+Risk.&rft.au=Watters%2C+J%3BMahabir%2C+S%3BDong%2C+Y%3BSpitz%2C+M%3BForman%2C+M&rft.aulast=Watters&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Retail Tobacco Availability: Measurement Considerations and Relation to Smoking Initiation. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40814002; 4801933 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Hunt, Y M AU - Jason, L A AU - Adams, M L AU - Pokorny, S B AU - Schoeny, M E Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Smoking KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40814002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Retail+Tobacco+Availability%3A+Measurement+Considerations+and+Relation+to+Smoking+Initiation.&rft.au=Hunt%2C+Y+M%3BJason%2C+L+A%3BAdams%2C+M+L%3BPokorny%2C+S+B%3BSchoeny%2C+M+E&rft.aulast=Hunt&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Inflammation-associated Serum and Colon Markers as Indicators of Nutritional Attenuation of Colon Carcinogenesis in AOM-induced Ob/Ob Mice Consuming Dietary Navy Beans and their Fractions. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40813783; 4801961 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Mentor-Marcel, R A AU - Bobe, G AU - Barrett, K G AU - Young, M R AU - Colburn, N H AU - Albert, P S AU - Bennink, M R AU - Lanza, E Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Diets KW - Mice KW - Carcinogenesis KW - Colon KW - Animal models KW - Beans KW - Navy KW - Nutrition KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40813783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Identification+of+Inflammation-associated+Serum+and+Colon+Markers+as+Indicators+of+Nutritional+Attenuation+of+Colon+Carcinogenesis+in+AOM-induced+Ob%2FOb+Mice+Consuming+Dietary+Navy+Beans+and+their+Fractions.&rft.au=Mentor-Marcel%2C+R+A%3BBobe%2C+G%3BBarrett%2C+K+G%3BYoung%2C+M+R%3BColburn%2C+N+H%3BAlbert%2C+P+S%3BBennink%2C+M+R%3BLanza%2C+E&rft.aulast=Mentor-Marcel&rft.aufirst=R&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Establishment of a Hereditary Tumor Bank for Molecular Epidemiology Studies. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40813214; 4802129 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Casali-da-Rocha, J AU - Almeida, L AU - Leitao, A AU - Seuanez, H AU - Ferreira, C G Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Tumors KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40813214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Establishment+of+a+Hereditary+Tumor+Bank+for+Molecular+Epidemiology+Studies.&rft.au=Casali-da-Rocha%2C+J%3BAlmeida%2C+L%3BLeitao%2C+A%3BSeuanez%2C+H%3BFerreira%2C+C+G&rft.aulast=Casali-da-Rocha&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Sex Hormones and Risk of Prostate Cancer: A Prospective Study. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40812397; 4801939 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Weiss, J M AU - Huang, W AU - Rinaldi, S AU - Fears, T R AU - Chatterjee, N AU - Hsing, A W AU - Crawford, E David AU - Andriole, G L AU - Kaaks, R AU - Hayes, R B Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Prostate cancer KW - Hormones KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40812397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Endogenous+Sex+Hormones+and+Risk+of+Prostate+Cancer%3A+A+Prospective+Study.&rft.au=Weiss%2C+J+M%3BHuang%2C+W%3BRinaldi%2C+S%3BFears%2C+T+R%3BChatterjee%2C+N%3BHsing%2C+A+W%3BCrawford%2C+E+David%3BAndriole%2C+G+L%3BKaaks%2C+R%3BHayes%2C+R+B&rft.aulast=Weiss&rft.aufirst=J&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insulin-like Growth Factors and Risk of Testicular Germ Cell Tumors. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40811687; 4802147 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Chia, V M AU - Quraishi, S AU - Sakoda, L C AU - Graubard, B I AU - Rubertone, M V AU - Chanock, S J AU - Erickson, R L AU - Stanczyk, F Z AU - McGlynn, K A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Growth factors KW - Tumors KW - Germ cells KW - Insulin-like growth factors KW - Testes KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40811687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Simultaneous+GC-EI-MS+Determination+of+D9-Tetrahydrocannabinol%2C+11-Hydroxy-D9-Tetrahydrocannabinol%2C+and+11-nor-9-Carboxy-D9-Tetrahydrocannabinol+in+Human+Urine+Following+Tandem+Enzyme-Alkaline+Hydrolysis&rft.au=Abraham%2C+T+T%3BLowe%2C+R+H%3BPirnay%2C+SO%3BDarwin%2C+W+D%3BHuestis%2C+MA&rft.aulast=Abraham&rft.aufirst=T&rft.date=2007-10-01&rft.volume=31&rft.issue=8&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serum Levels of Vitamin D Metabolites and Breast Cancer Risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40811329; 4802149 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Freedman, M AU - Chang, S AU - Falk, R T AU - Purdue, M P AU - Huang, W AU - McCarty, C A AU - Hollis, B W AU - Graubard, B I AU - Berg, C D AU - Ziegler, R G Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Breast cancer KW - Ovarian cancer KW - Vitamin D KW - Lung KW - Metabolites KW - Prostate KW - Serum levels KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40811329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Serum+Levels+of+Vitamin+D+Metabolites+and+Breast+Cancer+Risk+in+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+Cancer+Screening+Trial.&rft.au=Freedman%2C+M%3BChang%2C+S%3BFalk%2C+R+T%3BPurdue%2C+M+P%3BHuang%2C+W%3BMcCarty%2C+C+A%3BHollis%2C+B+W%3BGraubard%2C+B+I%3BBerg%2C+C+D%3BZiegler%2C+R+G&rft.aulast=Freedman&rft.aufirst=M&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PAH Exposure and Upper Gastrointestinal Cancers in China. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40810620; 4802169 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Gao, Y AU - Taylor, P Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - China, People's Rep. KW - Cancer KW - Pollution effects KW - Aromatic hydrocarbons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=PAH+Exposure+and+Upper+Gastrointestinal+Cancers+in+China.&rft.au=Gao%2C+Y%3BTaylor%2C+P&rft.aulast=Gao&rft.aufirst=Y&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Multiple Lifestyle Risk Factors for Cancer in Brazil. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40810577; 4802165 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Mendonca, A L AU - Martins, L F AU - Jardim, B C AU - Almeida, L M AU - Figueiredo, V C AU - Lozana, J A Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Brazil KW - Cancer KW - Risk factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40810577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Prevalence+of+Multiple+Lifestyle+Risk+Factors+for+Cancer+in+Brazil.&rft.au=Mendonca%2C+A+L%3BMartins%2C+L+F%3BJardim%2C+B+C%3BAlmeida%2C+L+M%3BFigueiredo%2C+V+C%3BLozana%2C+J+A&rft.aulast=Mendonca&rft.aufirst=A&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-ethyl-N,N-dipropylthiocarbamate (EPTC) Exposure and Cancer Incidence among Male Pesticide Applicators in the Agricultural Health Study, a Prospective Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40809096; 4802173 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Van Bemmel, D M AU - Visvanathan, K AU - Freeman, L. E. Beane AU - Coble, J B AU - Hoppin, J A AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40809096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=S-ethyl-N%2CN-dipropylthiocarbamate+%28EPTC%29+Exposure+and+Cancer+Incidence+among+Male+Pesticide+Applicators+in+the+Agricultural+Health+Study%2C+a+Prospective+Cohort.&rft.au=Van+Bemmel%2C+D+M%3BVisvanathan%2C+K%3BFreeman%2C+L.+E.+Beane%3BCoble%2C+J+B%3BHoppin%2C+J+A%3BAlavanja%2C+M.+C.R.&rft.aulast=Van+Bemmel&rft.aufirst=D&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cancer Incidence among Imazethapyr-exposed Pesticide Applicators in the Agricultural Health Study Cohort. T2 - Sixth Annual Frontiers in Cancer Prevention Research Conference AN - 40807725; 4802160 JF - Sixth Annual Frontiers in Cancer Prevention Research Conference AU - Koutros, S AU - Hoppin, J A AU - Lynch, C F AU - Christensen, C AU - Lee, W AU - Freeman, L Beane AU - Rusiecki, J AU - Hou, L AU - Ma, X. AU - Zheng, T AU - Alavanja, M. C.R. Y1 - 2007/12/05/ PY - 2007 DA - 2007 Dec 05 KW - Cancer KW - Pesticides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40807725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.atitle=Cancer+Incidence+among+Imazethapyr-exposed+Pesticide+Applicators+in+the+Agricultural+Health+Study+Cohort.&rft.au=Koutros%2C+S%3BHoppin%2C+J+A%3BLynch%2C+C+F%3BChristensen%2C+C%3BLee%2C+W%3BFreeman%2C+L+Beane%3BRusiecki%2C+J%3BHou%2C+L%3BMa%2C+X.%3BZheng%2C+T%3BAlavanja%2C+M.+C.R.&rft.aulast=Koutros&rft.aufirst=S&rft.date=2007-12-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Sixth+Annual+Frontiers+in+Cancer+Prevention+Research+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.aacr.org/home/scientists/meetings--workshops/frontiers-in-c ancer-prevention-research/abstracts.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Epstein-Barr virus serology and gastric cancer incidence and survival AN - 759320443; 13760000 AB - Among 185 cases of gastric cancer and 200 controls in Linxian, China, Epstein-Barr virus (EBV) seropositivity was not associated with increased risk of gastric cancer. High EBV nuclear antigen titres were associated with longer survival in cardia cancer cases, possibly due to chance.British Journal of Cancer (2007) 97, 1567-1569; doi:10.1038/sj.bjc.6604063 www.bjcancer.com Published online 6 November 2007 JF - British Journal of Cancer AU - Koshiol, J AU - Qiao, Y-L AU - Mark, S D AU - Dawsey, S M AU - Abnet, C C AU - Kamangar, F AU - Lennette, E T AU - Dong, Z-W AU - Taylor, P R AD - [1] 1 Cancer Prevention Fellowship, Division of Cancer Prevention, National Cancer Institute, 6120 Executive Blvd., MSC 7236, Bethesda, MD, USA [2] 2 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2007/12/03/ PY - 2007 DA - 2007 Dec 03 SP - 1567 EP - 1569 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 97 IS - 11 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Virology & AIDS Abstracts KW - Epstein-Barr virus KW - Survival KW - China, People's Rep. KW - survival KW - Gastric cancer KW - Serology KW - Cancer KW - Internet KW - R2 23060:Medical and environmental health KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/759320443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Altered+chemokine+profile+associated+with+exacerbated+autoimmune+pathology+under+conditions+of+genetic+interferon-gamma+deficiency.&rft.au=Su%2C+Shao+Bo%3BGrajewski%2C+Rafael+S%3BLuger%2C+Dror%3BAgarwal%2C+Rajeev+K%3BSilver%2C+Phyllis+B%3BTang%2C+Jun%3BTuo%2C+Jingsheng%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Su&rft.aufirst=Shao&rft.date=2007-10-01&rft.volume=48&rft.issue=10&rft.spage=4616&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Survival; Gastric cancer; Serology; Internet; survival; Cancer; Epstein-Barr virus; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6604063 ER - TY - JOUR T1 - Gallstones and the risk of biliary tract cancer: a population-based study in China AN - 20516033; 8044893 AB - We conducted a population-based study of 627 patients with biliary tract cancers (368 of gallbladder, 191 bile duct, and 68 ampulla of Vater), 1037 with biliary stones, and 959 healthy controls randomly selected from the Shanghai population, all personally interviewed. Gallstone status was based on information from self-reports, imaging procedures, surgical notes, and medical records. Among controls, a transabdominal ultrasound was performed to detect asymptomatic gallstones. Gallstones removed from cancer cases and gallstone patients were classified by size, weight, colour, pattern, and content of cholesterol, bilirubin, and bile acids. Of the cancer patients, 69% had gallstones compared with 23% of the population controls. Compared with subjects without gallstones, odds ratios associated with gallstones were 23.8 (95% confidence interval (CI), 17.0-33.4), 8.0 (95% CI 5.6-11.4), and 4.2 (95% CI 2.5-7.0) for cancers of the gallbladder, extrahepatic bile ducts, and ampulla of Vater, respectively, persisting when restricted to those with gallstones at least 10 years prior to cancer. Biliary cancer risks were higher among subjects with both gallstones and self-reported cholecystitis, particularly for gallbladder cancer (OR = 34.3, 95% CI 19.9-59.2). Subjects with bile duct cancer were more likely to have pigment stones, and with gallbladder cancer to have cholesterol stones (P < 0.001). Gallstone weight in gallbladder cancer was significantly higher than in gallstone patients (4.9 vs 2.8 grams; P = 0.001). We estimate that in Shanghai 80% (95% CI 75-84%), 59% (56-61%), and 41% (29-59%) of gallbladder, bile duct, and ampulla of Vater cancers, respectively, could be attributed to gallstones. JF - British Journal of Cancer AU - Hsing, A W AU - Gao, Y-T AU - Han, T-Q AU - Rashid, A AU - Sakoda, L C AU - Wang, B-S AU - Shen, M-C AU - Zhang, B-H AU - Niwa, S AU - Chen, J AU - Fraumeni, JF Jr AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, EPS 5024, MSC 7234, 6120 Executive Blvd., Bethesda, MD 20852-7234, USA, hsinga@mail.nih.gov Y1 - 2007/12/03/ PY - 2007 DA - 2007 Dec 03 SP - 1577 EP - 1582 VL - 97 IS - 11 SN - 0007-0920, 0007-0920 KW - gallstones KW - Risk Abstracts KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Population dynamics KW - cholesterol KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20516033?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Gallstones+and+the+risk+of+biliary+tract+cancer%3A+a+population-based+study+in+China&rft.au=Hsing%2C+A+W%3BGao%2C+Y-T%3BHan%2C+T-Q%3BRashid%2C+A%3BSakoda%2C+L+C%3BWang%2C+B-S%3BShen%2C+M-C%3BZhang%2C+B-H%3BNiwa%2C+S%3BChen%2C+J%3BFraumeni%2C+JF+Jr&rft.aulast=Hsing&rft.aufirst=A&rft.date=2007-12-03&rft.volume=97&rft.issue=11&rft.spage=1577&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6604047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - China, People's Rep., Shanghai; China, People's Rep.; Cancer; cholesterol; Population dynamics DO - http://dx.doi.org/10.1038/sj.bjc.6604047 ER - TY - CPAPER T1 - Secondary Prevention Among Adolescents: Current Knowledge and Intervention Studies Within the Adolescent Trials Network T2 - 2007 National HIV Prevention Conference AN - 39675049; 4737252 JF - 2007 National HIV Prevention Conference AU - Allison, S Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Adolescents KW - Prevention KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39675049?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Secondary+Prevention+Among+Adolescents%3A+Current+Knowledge+and+Intervention+Studies+Within+the+Adolescent+Trials+Network&rft.au=Allison%2C+S&rft.aulast=Allison&rft.aufirst=S&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Finding What Works in HIV Risk Reduction Interventions with Alcohol Users: Observations Based on a Systematic Review of the Literature, 1996-2007 T2 - 2007 National HIV Prevention Conference AN - 39674423; 4737169 JF - 2007 National HIV Prevention Conference AU - Freeman, R C Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Reviews KW - Risk reduction KW - Alcohols KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=Finding+What+Works+in+HIV+Risk+Reduction+Interventions+with+Alcohol+Users%3A+Observations+Based+on+a+Systematic+Review+of+the+Literature%2C+1996-2007&rft.au=Freeman%2C+R+C&rft.aulast=Freeman&rft.aufirst=R&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview Of Biomedical Intervention Research and Methods T2 - 2007 National HIV Prevention Conference AN - 39662375; 4737035 JF - 2007 National HIV Prevention Conference AU - Dieffenbach, C W Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Intervention KW - Reviews KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39662375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Some+evidence+of+effects+of+environmental+chemicals+on+the+endocrine+system+in+children.&rft.au=Rogan%2C+Walter+J%3BRagan%2C+N+Beth&rft.aulast=Rogan&rft.aufirst=Walter&rft.date=2007-10-01&rft.volume=210&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=14384639&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Overview of HIV Vaccines and PAVE-100 T2 - 2007 National HIV Prevention Conference AN - 39643045; 4737038 JF - 2007 National HIV Prevention Conference AU - Kripke, K Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Human immunodeficiency virus KW - Vaccines KW - Reviews KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39643045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=An+Overview+of+HIV+Vaccines+and+PAVE-100&rft.au=Kripke%2C+K&rft.aulast=Kripke&rft.aufirst=K&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV and Mental Illness: Intervention and Prevention Priorites T2 - 2007 National HIV Prevention Conference AN - 39593008; 4737290 JF - 2007 National HIV Prevention Conference AU - Grossman, C I Y1 - 2007/12/02/ PY - 2007 DA - 2007 Dec 02 KW - Mental disorders KW - Human immunodeficiency virus KW - Prevention KW - Intervention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+National+HIV+Prevention+Conference&rft.atitle=HIV+and+Mental+Illness%3A+Intervention+and+Prevention+Priorites&rft.au=Grossman%2C+C+I&rft.aulast=Grossman&rft.aufirst=C&rft.date=2007-12-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+National+HIV+Prevention+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.2007nhpc.org/conference_program.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Drug Web Sites AN - 872124484; 13617740 JF - Toxicologic Pathology AU - Ward, J M AD - , NIH and SoBran, Inc., Bethesda, MD, jw116y@nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1044 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 35 IS - 7 SN - 0192-6233, 0192-6233 KW - Toxicology Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/872124484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+Pathology&rft.atitle=Drug+Web+Sites&rft.au=Ward%2C+J+M&rft.aulast=Ward&rft.aufirst=J&rft.date=2007-12-01&rft.volume=35&rft.issue=7&rft.spage=1044&rft.isbn=&rft.btitle=&rft.title=Toxicologic+Pathology&rft.issn=01926233&rft_id=info:doi/10.1080%2F01926230701756407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 DO - http://dx.doi.org/10.1080/01926230701756407 ER - TY - JOUR T1 - A Mycobacterium tuberculosis-Derived Lipid Inhibits Membrane Fusion by Modulating Lipid Membrane Domains AN - 864412733; 14419275 AB - Tuberculosis is an infectious and potentially fatal disease caused by the acid-fast bacillus Mycobacterium tuberculosis (MTB). One hallmark of a tuberculosis infection is the ability of the bacterium to subvert the normal macrophage defense mechanism of the host immune response. Lipoarabinomannan (LAM), an integral component of the MTB cell wall, is released when MTBs are taken into phagosomes and has been reported to be involved in the inhibition of phago-lysosomal (P-L) fusion. However, the physical chemistry of the effects of LAM on lipid membrane structure relative to P-L fusion has not been studied. We produced membranes in vitro composed of dioleoylphosphatidylcholine, sphingomyelin, and cholesterol to simulate phagosomal lipid membranes and quantified the effects of the addition of LAM to these membranes, using fluorescence resonance energy transfer assays and atomic force microscopy. We found that LAM inhibits vesicle fusion and markedly alters lipid membrane domain morphology and sphingomyelin-chollesterol/dioleoylphosphatidylcholine ratios. These data demonstrate that LAM induces a dramatic reorganization of lipid membranes in vitro and clarifies the role of LAM in the inhibition of P-L fusion and the survival of the MTB within the macrophage. JF - Biophysical Journal AU - Hayakawa, Eri AU - Tokumasu, Fuyuki AU - Nardone, Glenn A AU - Jin, Albert J AU - Hackley, Vince A AU - Dvorak, James A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 4018 EP - 4030 PB - Biophysical Society VL - 93 IS - 11 SN - 0006-3495, 0006-3495 KW - Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Macrophages KW - Data processing KW - sphingomyelin KW - Membrane fusion KW - Phagosomes KW - atomic force microscopy KW - fluorescence resonance energy transfer KW - Cholesterol KW - Infection KW - Lipid rafts KW - Lipid membranes KW - Tuberculosis KW - Defense mechanisms KW - Immune response KW - Bacillus KW - Lipoarabinomannans KW - Mycobacterium tuberculosis KW - Vesicle fusion KW - Cell walls KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/864412733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Journal&rft.atitle=A+Mycobacterium+tuberculosis-Derived+Lipid+Inhibits+Membrane+Fusion+by+Modulating+Lipid+Membrane+Domains&rft.au=Hayakawa%2C+Eri%3BTokumasu%2C+Fuyuki%3BNardone%2C+Glenn+A%3BJin%2C+Albert+J%3BHackley%2C+Vince+A%3BDvorak%2C+James+A&rft.aulast=Hayakawa&rft.aufirst=Eri&rft.date=2007-12-01&rft.volume=93&rft.issue=11&rft.spage=4018&rft.isbn=&rft.btitle=&rft.title=Biophysical+Journal&rft.issn=00063495&rft_id=info:doi/10.1529%2Fbiophysj.107.104075 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-11-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Data processing; sphingomyelin; Membrane fusion; Phagosomes; atomic force microscopy; fluorescence resonance energy transfer; Cholesterol; Infection; Lipid rafts; Lipid membranes; Tuberculosis; Immune response; Defense mechanisms; Lipoarabinomannans; Cell walls; Vesicle fusion; Bacillus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1529/biophysj.107.104075 ER - TY - JOUR T1 - Analysis of auditory phenotype and karyotype in 200 females with Turner syndrome. AN - 85408387; pmid-17982369 AB - Turner syndrome is the most common sex chromosome disorder in females, and is caused by a total or partial deletion of one X chromosome. The purpose of this study was to describe the auditory phenotype in a large group of individuals with Turner Syndrome, with analysis focusing on hearing loss and age, as well as the phenotypic relationship to karyotype variation.Our analysis of auditory function was part of a large-scale, natural history study in which clinical and genetic factors related to Turner syndrome were examined. This ascertainment avoids the bias inherent in studies of patients referred to audiology or otolaryngology specialty clinics. Analysis included data from 200 females with Turner syndrome ranging in age from 7 to 61 yr (mean=27.9 yr).We observed hearing loss in approximately one-half of females with Turner syndrome, and report on a common, previously unlabeled audiometric configuration found in 24% of ears tested. Our cross-sectional design revealed an observable deterioration in hearing loss above the averaged rate of age-related hearing loss seen in an otologically screened, standardized population. Karyotype analysis revealed air conduction thresholds that were significantly poorer in the 46, XdelXp and 46, XiXq groups than in the 46, XdelXq group.This natural history study provides a more representative description of the auditory phenotype associated with Turner syndrome than previous studies that may have been biased by the method of ascertainment. Correlative analysis of Turner syndrome-specific hearing loss features with karyotype revealed that air conduction threshold elevations are associated with loss of the p arm of chromosome X. Our cross-sectional data indicate a loss of hearing sensitivity at an accelerated rate beyond a normal age-related decline, which warrants continued audiologic monitoring in all females with Turner syndrome regardless of a history of normal hearing. JF - Ear and hearing AU - King, Kelly A AU - Makishima, Tomoko AU - Zalewski, Christopher K AU - Bakalov, Vladimir K AU - Griffith, Andrew J AU - Bondy, Carolyn A AU - Brewer, Carmen C AD - Otolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 831 EP - 841 VL - 28 IS - 6 SN - 0196-0202, 0196-0202 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Child KW - Chromosome Deletion KW - Chromosomes, Human, X KW - Female KW - Gene Frequency KW - Genetic Predisposition to Disease KW - *Hearing KW - Humans KW - Karyotyping KW - Male KW - Middle Aged KW - Phenotype KW - *Turner Syndrome: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85408387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ear+and+hearing&rft.atitle=Analysis+of+auditory+phenotype+and+karyotype+in+200+females+with+Turner+syndrome.&rft.au=King%2C+Kelly+A%3BMakishima%2C+Tomoko%3BZalewski%2C+Christopher+K%3BBakalov%2C+Vladimir+K%3BGriffith%2C+Andrew+J%3BBondy%2C+Carolyn+A%3BBrewer%2C+Carmen+C&rft.aulast=King&rft.aufirst=Kelly&rft.date=2007-12-01&rft.volume=28&rft.issue=6&rft.spage=831&rft.isbn=&rft.btitle=&rft.title=Ear+and+hearing&rft.issn=01960202&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Normal hearing in alpha-galactosidase A-deficient mice, the mouse model for Fabry disease. AN - 85407587; pmid-17933476 AB - Fabry disease (OMIM 301500) is a rare X-linked recessive disorder caused by mutations in the alpha-galactosidase gene (Gla). Loss of Gla activity leads to the abnormal accumulation of glycosphingolipids in lysosomes of predominantly vascular endothelial cells. Clinically the disorder presents with angiokeratomas, clouding of the cornea, and renal, cardiac, and cerebrovascular complications. In addition, there is an increased incidence of sensorineural hearing loss in Fabry patients. In this study, we investigated the loss of alpha-galactosidase A activity on hearing function in Gla-deficient mice (Gla(tm1Kul)). Gla mRNA was readily detected in the cochlea of 2- and 12-month old C57BL/6J and C3HeB/FeJ mice. The targeted allele was introgressed to the normal hearing C3HeB/FeJ strain to eliminate confounding genetic background effects. Auditory brain stem responses (ABR) to click, 8-, 16-, and 32 kHz stimuli measured at regular intervals from animals at the N4 backcross generation and from N4F1 hybrids demonstrated normal hearing in hemizygous and homozygous mutant mice up to 76 weeks of age. By histological criteria, the cyto-architecture of the mutant cochlea showed a normal appearance. The data demonstrate that in the mouse the loss of alpha-galactosidase A activity is genetically or biochemically buffered and not sufficient per se to cause an appreciable degree of hearing impairment. JF - Hearing research AU - Noben-Trauth, Konrad AU - Neely, Harold AU - Brady, Roscoe O AD - Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20855, USA. nobentk@nidcd.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 10 EP - 14 VL - 234 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation KW - Animals KW - Cochlea: enzymology KW - Cochlea: pathology KW - *Cochlea: physiopathology KW - Disease Models, Animal KW - Evoked Potentials, Auditory, Brain Stem KW - Fabry Disease: complications KW - Fabry Disease: enzymology KW - Fabry Disease: genetics KW - *Fabry Disease: physiopathology KW - Female KW - *Hearing KW - Hearing Loss: enzymology KW - Hearing Loss: etiology KW - Hearing Loss: physiopathology KW - Male KW - Mice KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Mice, Knockout KW - RNA, Messenger: metabolism KW - Time Factors KW - alpha-Galactosidase: genetics KW - *alpha-Galactosidase: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85407587?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Human+Gene+Therapy&rft.atitle=Prolonged+Reduction+of+CCR5+Expression+in+Multiple+Hematopoietic+Cell+Lineages+by+RNA+Interference+Through+CD34%2B+Cell+Transplant+in+Non-Human+Primates&rft.au=Donahue%2C+R%3BAn%2C+D-S%3BKamata%2C+M%3BMattapallil%2C+J%3BPoon%2C+B%3BMetzger%2C+M%3BMao%2C+S-H%3BBonifacino%2C+A%3BKrouse%2C+A%3BDarlix%2C+J-L%3BBaltimore%2C+D%3BQin%2C+FX-F%3BChen%2C+ISY&rft.aulast=Donahue&rft.aufirst=R&rft.date=2007-10-01&rft.volume=18&rft.issue=10&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Perceived ambiguity about cancer prevention recommendations: associations with cancer-related perceptions and behaviours in a US population survey AN - 746156604; 7983280 AB - Background Health information reaching the public today is often characterized by what decision theorists have termed 'ambiguity'- i.e. uncertainty regarding the information's reliability, credibility or adequacy. This is a critical problem, as growing research suggests that ambiguity has important effects-promoting pessimistic judgments about risks and potential outcomes of risk-reducing behaviours, and lowering adoption of these behaviours. However, little is known about the public's perceptions of ambiguity in the health information domain, the effects of these perceptions, and the factors that influence these effects. Objective To examine associations between perceived ambiguity regarding cancer prevention recommendations and prevention-related perceptions and behaviours, and to explore how these associations differ by cancer type. Study design and participants Cross-sectional analysis of data on 4070 adults participating in the 2005 US Health Information National Trends Survey. Main variables and outcome measures We examined associations between perceived ambiguity about colon, skin and lung cancer prevention recommendations and two main outcome variables: (i) risk-related cognitions (perceived cancer risk and preventability, cancer-related worry) and (ii) risk-modifying behaviours (colon cancer screening, sunscreen use and smoking abstinence). Results Perceived ambiguity was inversely associated with perceptions of the preventability of all three cancers, and with cancer-specific risk-modifying behaviours including sigmoidoscopy-colonoscopy testing, sunscreen use and smoking abstinence. Relationships with cancer risk perceptions and worry varied across different cancer types. Conclusions Perceived ambiguity about cancer prevention recommendations has significant and predictable associations with cancer prevention-related cognitions and behaviours, and some associations differ by cancer type. These findings have implications for future research and communication efforts. JF - Health Expectations AU - Han, Paul KJ AU - Moser, Richard P AU - Klein, William MP AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA, hanp@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 321 EP - 336 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 10 IS - 4 SN - 1369-6513, 1369-6513 KW - Risk Abstracts KW - ambiguity KW - cancer prevention KW - health behaviours KW - perceptions KW - recommendations KW - sexual behavior KW - Skin KW - Cancer KW - Public opinion KW - Smoking KW - risk reduction KW - USA KW - cognitive ability KW - Communications KW - Perception KW - prevention KW - Lung cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746156604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Perceived+ambiguity+about+cancer+prevention+recommendations%3A+associations+with+cancer-related+perceptions+and+behaviours+in+a+US+population+survey&rft.au=Han%2C+Paul+KJ%3BMoser%2C+Richard+P%3BKlein%2C+William+MP&rft.aulast=Han&rft.aufirst=Paul&rft.date=2007-12-01&rft.volume=10&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2007.00456.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Public opinion; risk reduction; Smoking; sexual behavior; Skin; Communications; cognitive ability; Perception; prevention; Cancer; Lung cancer; USA DO - http://dx.doi.org/10.1111/j.1369-7625.2007.00456.x ER - TY - JOUR T1 - Tobacco use amongst children in Karnataka AN - 746084987; 13021557 AB - Objective To estimate the prevalence, pattern and correlates of tobacco use amongst the 13-15 year olds in schools of Karnataka Methods A three stage (area, school level and class level) cluster sample design was adopted and 80 schools from 12 districts of the statewere selected. A total of 4,110 students participated in the study with an overall response rate of 87%. Results Point prevalence of tobacco use amongst 13-15 year old was 4.9%. Current tobacco use was predominantly a male feature and use of smokeless variety predominated (transitional Kamataka (8.2%); metropolis (6.8%); rural (3.4%). One third of current tobacco users (30.8%) purchased tobacco product in a store and one-fifth used it at home. Nearly half of the never smokers (43% to 56.7%) were exposed to tobacco smoke outside home and 83% favored a ban on smoking in public places. A male tobacco user was perceived to have more friends and was reported to make them look attractive. Print media was a predominant source of message, more so in the metropolitan region. Only one-third (31.6%) reported that the reasons of tobacco usage amongst youth was discussed in formal school settings. Conclusion GYTS Kamataka has provided reliable estimates and shown the feasibility of implementing a surveillance programme. Specific challenges for Public health that emerge from the study are increasing number of users in transitional areas, continued media exposure, tobacco users being perceived to be popular and attractive, easy and relatively unrestricted access, lack of systematic support within schools and social acceptance of tobacco use at home. The need of the hour is to target and focus interventions through comprehensive programmes aimed at children, school authorities, parents and policy makers. JF - Indian Journal of Pediatrics AU - Gururaj, G AU - Girish, N AD - Department of Epidemiology, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India, guru@nimhans.kar.nic.in Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1095 EP - 1098 VL - 74 IS - 12 SN - 0019-5456, 0019-5456 KW - Health & Safety Science Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746084987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Indian+Journal+of+Pediatrics&rft.atitle=Tobacco+use+amongst+children+in+Karnataka&rft.au=Gururaj%2C+G%3BGirish%2C+N&rft.aulast=Gururaj&rft.aufirst=G&rft.date=2007-12-01&rft.volume=74&rft.issue=12&rft.spage=1095&rft.isbn=&rft.btitle=&rft.title=Indian+Journal+of+Pediatrics&rft.issn=00195456&rft_id=info:doi/10.1007%2FS12098-007-0204-X LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1007/S12098-007-0204-X ER - TY - JOUR T1 - Evaluation of dimethoxydop-NU as a novel anti-tumor agent. AN - 70116562; 18365543 AB - Dimethoxydop-NU, 1-[2-{3-(2-Chloroethyl)-3-nitrosoureido}ethyl]-3,4-dimethoxy-benzene (Compound 1), was synthesized from 3,4-dimethoxy-phenethylamine as a novel anti-tumor agent based on the structures of the clinical drug CCNU and dopamine, an important endogenous biological amine having anti-angiogenesis property. In vitro screening in two human tumor cell lines, namely promyelocytic leukemia HL-60 and histiocytic lymphoma U-937, revealed its cytotoxicity greater than that of hydroxyurea and comparable to BCNU used as standards. Its in vivo anti-tumoral potency was assessed in the murine ascites tumors Sarcoma-180 (S-180) and Ehrlich ascites carcinoma (EAC) by measuring the increase in median survival times of drug treated (T) over untreated control (C) mice. Results revealed significant tumor regression effects in these tumors. The survival time of treated mice was markedly increased by combination of the compound 1 with dopamine hydrochloride. Its toxicity was assessed in vivo in normal and EAC bearing mice by measuring drug-induced changes in hematological parameters, femoral bone marrow and splenic cellularities as well as biochemical parameters sequentially on days 9, 14 and 19 following drug treatment at the optimum dose of 30 mg/kg from day 1 to 7. Results indicated that initial suppression in the femoral bone marrow cellularity seen on day 9 reached normalcy by day 19. Other parameters were within normal limit. Histopathological studies of liver revealed mild hepatotoxicity on day 9 in treated groups that substantially recovered on day 19. Similar studies with heart and kidney revealed no cardio toxicity or nephrotoxicity. Compound 1 comparable to standards inhibited the synthesis of DNA and RNA in S-180 tumor cells. JF - Journal of experimental & clinical cancer research : CR AU - Mukherjee, A AU - Dutta, S AU - Sanyal, U AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata, India. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 489 EP - 497 VL - 26 IS - 4 SN - 0392-9078, 0392-9078 KW - 1-(2-(3-(2-chloroethyl)-3-nitrosoureido)ethyl)-3,4-dimethoxy-benzene KW - 0 KW - Antineoplastic Agents KW - Nitrosourea Compounds KW - Thymidine KW - VC2W18DGKR KW - Uridine KW - WHI7HQ7H85 KW - Index Medicus KW - Thymidine -- metabolism KW - Drug Screening Assays, Antitumor KW - Animals KW - Humans KW - Uridine -- metabolism KW - Mice KW - Cell Line, Tumor KW - Drug Evaluation, Preclinical KW - Nitrosourea Compounds -- pharmacology KW - Nitrosourea Compounds -- chemical synthesis KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70116562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.atitle=Evaluation+of+dimethoxydop-NU+as+a+novel+anti-tumor+agent.&rft.au=Mukherjee%2C+A%3BDutta%2C+S%3BSanyal%2C+U&rft.aulast=Mukherjee&rft.aufirst=A&rft.date=2007-12-01&rft.volume=26&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Journal+of+experimental+%26+clinical+cancer+research+%3A+CR&rft.issn=03929078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-11 N1 - Date created - 2008-03-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An open-label trial of riluzole, a glutamate antagonist, in children with treatment-resistant obsessive-compulsive disorder. AN - 70106862; 18315448 AB - Obsessive-compulsive disorder (OCD) in childhood is often refractory to treatment. Riluzole, a glutamate antagonist, has theoretical support as an alternative pharmacological treatment and has demonstrated possible benefit in some open-label trials in adults with OCD. Six subjects, ages 8-16 years, were enrolled in a 12-week open-label trial of riluzole for OCD symptoms that had resisted prior treatments. OCD symptoms and adverse effects of drug were monitored. Four of 6 subjects had clear benefit, with reduction of more than 46% (39% overall) on Children's Yale-Brown Obsessive-Compulsive Scale, and "Much Improved" or "Very Much Improved" on the Clinical Global Impressions-Improvement scale. Two subjects had no clinically meaningful change in symptom severity by 12 weeks, but 1 subject improved thereafter. There were no adverse effects of drug sufficient to cause discontinuation or reduction of dose. All subjects elected to continue riluzole after the 12-week trial. Riluzole may be beneficial for treatment-resistant OCD in young subjects and seems well tolerated. A placebo-controlled trial of the drug is planned. JF - Journal of child and adolescent psychopharmacology AU - Grant, Paul AU - Lougee, Lorraine AU - Hirschtritt, Matthew AU - Swedo, Susan E AD - Pediatrics and Developmental Neuropsychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. paul.grant@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 761 EP - 767 VL - 17 IS - 6 SN - 1044-5463, 1044-5463 KW - Excitatory Amino Acid Antagonists KW - 0 KW - Riluzole KW - 7LJ087RS6F KW - Index Medicus KW - Severity of Illness Index KW - Psychiatric Status Rating Scales KW - Humans KW - Treatment Outcome KW - Drug Resistance KW - Child KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Riluzole -- adverse effects KW - Excitatory Amino Acid Antagonists -- therapeutic use KW - Obsessive-Compulsive Disorder -- drug therapy KW - Excitatory Amino Acid Antagonists -- adverse effects KW - Riluzole -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70106862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=An+open-label+trial+of+riluzole%2C+a+glutamate+antagonist%2C+in+children+with+treatment-resistant+obsessive-compulsive+disorder.&rft.au=Grant%2C+Paul%3BLougee%2C+Lorraine%3BHirschtritt%2C+Matthew%3BSwedo%2C+Susan+E&rft.aulast=Grant&rft.aufirst=Paul&rft.date=2007-12-01&rft.volume=17&rft.issue=6&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/10.1089%2Fcap.2007.0021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-03-04 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00251303; ClinicalTrials.gov N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1089/cap.2007.0021 ER - TY - JOUR T1 - Buprenorphine and norbuprenorphine in hair of pregnant women and their infants after controlled buprenorphine administration. AN - 70101713; 17921260 AB - Buprenorphine is under investigation as a pharmacotherapeutic agent for treating opioid dependence in pregnant women. We hypothesized that there would be a relationship between the cumulative maternal dose of buprenorphine during pregnancy and the concentration of buprenorphine and norbuprenorphine in maternal and infant hair. This study examined buprenorphine and norbuprenorphine concentrations in hair obtained from 9 buprenorphine-maintained pregnant women and 4 of their infants. Specimens were analyzed by liquid chromatography-tandem mass spectrometry with limits of quantification of 3.0 pg/mg. All maternal hair specimens were washed with methylene chloride before analysis, and when sufficient amounts of maternal hair were available, specimens also were analyzed without washing. Infant hair specimens were not washed. Buprenorphine concentrations were significantly greater in unwashed hair than washed hair (P = 0.031). Norbuprenorphine concentrations were significantly greater than buprenorphine concentrations in both maternal (P = 0.0097) and infant hair (P = 0.0033). There were statistically significant associations between the cumulative maternal dose of buprenorphine administered and the concentrations of buprenorphine (washed, P <0.0001; unwashed, P = 0.0004), norbuprenorphine (washed, P <0.0001; unwashed, P = 0.0005), and buprenorphine plus norbuprenorphine (washed, P <0.0001; unwashed, P = 0.0005) for both washed and unwashed maternal hair specimens. There was a significant positive association between concentrations of buprenorphine and norbuprenorphine in maternal hair (washed, P <0.0001; unwashed, P = 0.0003), a trend for this association in infant hair (P = 0.08), and an association between buprenorphine concentrations in maternal unwashed hair and infant hair (P = 0.0002). The buprenorphine:norbuprenorphine ratio increased in distal segments. Buprenorphine treatment during gestation provides an opportunity for monitoring drug disposition in maternal and fetal tissues under controlled conditions. JF - Clinical chemistry AU - Goodwin, Robert S AU - Wilkins, Diana G AU - Averin, Olga AU - Choo, Robin E AU - Schroeder, Jennifer R AU - Jasinski, Donald R AU - Johnson, Rolley E AU - Jones, Hendrée E AU - Huestis, Marilyn A AD - Chemistry and Drug Metabolism Section, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2136 EP - 2143 VL - 53 IS - 12 SN - 0009-9147, 0009-9147 KW - Receptors, Opioid, kappa KW - 0 KW - Receptors, Opioid, mu KW - Buprenorphine KW - 40D3SCR4GZ KW - norbuprenorphine KW - 7E53B4O073 KW - Index Medicus KW - Infant KW - Receptors, Opioid, mu -- agonists KW - Humans KW - Receptors, Opioid, kappa -- antagonists & inhibitors KW - Adult KW - Infant, Newborn KW - Chromatography, Liquid KW - Tissue Distribution KW - Tandem Mass Spectrometry KW - Female KW - Pregnancy KW - Buprenorphine -- analysis KW - Pregnancy Complications -- metabolism KW - Buprenorphine -- therapeutic use KW - Heroin Dependence -- metabolism KW - Heroin Dependence -- drug therapy KW - Hair -- chemistry KW - Buprenorphine -- pharmacokinetics KW - Pregnancy Complications -- drug therapy KW - Buprenorphine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70101713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+chemistry&rft.atitle=Buprenorphine+and+norbuprenorphine+in+hair+of+pregnant+women+and+their+infants+after+controlled+buprenorphine+administration.&rft.au=Goodwin%2C+Robert+S%3BWilkins%2C+Diana+G%3BAverin%2C+Olga%3BChoo%2C+Robin+E%3BSchroeder%2C+Jennifer+R%3BJasinski%2C+Donald+R%3BJohnson%2C+Rolley+E%3BJones%2C+Hendr%C3%A9e+E%3BHuestis%2C+Marilyn+A&rft.aulast=Goodwin&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=53&rft.issue=12&rft.spage=2136&rft.isbn=&rft.btitle=&rft.title=Clinical+chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-10 N1 - Date created - 2008-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lighting a backfire to quench the blaze: a combined drug approach targeting the vanilloid receptor TRPV1. AN - 70058103; 18199852 AB - Drug interactions and drug specificity are core themes for the pharmacologist. The paper discussed in this Viewpoint exploits the former to attain the latter. How can one improve local anesthetics so that they block pain but permit normal sensation? QX-314 is a charged derivative of lidocaine without anesthetic activity because it cannot diffuse across the cell membrane to access the neuronal voltage-dependent sodium channel. Capsaicin is a selective activator of the TRPV1 channel, the localization of which is restricted to sensory C-fiber neurons involved in nociception. Because the large pore size of the activated TRPV1 allows passage of large cations such as QX-314, combined treatment with capsaicin and QX-314 puts QX-314 uniquely into that subclass of neurons mediating pain, thereby achieving sensational specificity. JF - Molecular interventions AU - Blumberg, Peter M AD - Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. blumberp@dc37a.nci.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 310 EP - 312 VL - 7 IS - 6 SN - 1534-0384, 1534-0384 KW - Sodium Channel Blockers KW - 0 KW - TRPV Cation Channels KW - Capsaicin KW - S07O44R1ZM KW - Index Medicus KW - Animals KW - Drug Interactions KW - Neurons, Afferent -- chemistry KW - Models, Molecular KW - Humans KW - Neurons, Afferent -- drug effects KW - Models, Neurological KW - Capsaicin -- administration & dosage KW - Sodium Channel Blockers -- administration & dosage KW - Neurons, Afferent -- physiology KW - TRPV Cation Channels -- chemistry KW - TRPV Cation Channels -- agonists KW - TRPV Cation Channels -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70058103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=MAC1+mediates+LPS-induced+production+of+superoxide+by+microglia%3A+the+role+of+pattern+recognition+receptors+in+dopaminergic+neurotoxicity.&rft.au=Pei%2C+Zhong%3BPang%2C+Hao%3BQian%2C+Li%3BYang%2C+Sufen%3BWang%2C+Tonggauang%3BZhang%2C+Wei%3BWu%2C+Xeufei%3BDallas%2C+Shannon%3BWilson%2C+Belinda%3BReece%2C+Jeffrey+M%3BMiller%2C+David+S%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Pei&rft.aufirst=Zhong&rft.date=2007-10-01&rft.volume=55&rft.issue=13&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-17 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1124/mi.7.6.5 ER - TY - JOUR T1 - Xerostomia: causes and treatment. AN - 70053453; 18198958 AB - When reduced salivary flow causes perpetual dry and sticky mucosa or sticky, stringy saliva, it becomes xerostomia-not a disease, but a symptom. Up to 30% of various populations self-report dry mouth (xerostomia) or have proven low salivary flow rates. Saliva is necessary for digestion and dental health, and it may have yet-unidentified immunological roles in humans. Xerostomia can lead to digestive problems, weight loss, and accelerated dental decay. Medications-several hundred of them-can cause or exacerbate xerostomia. Cancer, autoimmune diseases, and bone marrow transplants are associated with xerostomia. Including a dentist on the treatment team is essential for residents with dry mouth. As xerostomia progresses, they should shift focus primarily to prevention, maintenance, oral comfort, and emergency treatment. In all stages, they should keep treatment noninvasive if possible. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Wick, Jeanette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 985 EP - 992 VL - 22 IS - 12 SN - 0888-5109, 0888-5109 KW - Quinuclidines KW - 0 KW - Thiophenes KW - Pilocarpine KW - 01MI4Q9DI3 KW - cevimeline KW - K9V0CDQ56E KW - Index Medicus KW - Thiophenes -- therapeutic use KW - Pilocarpine -- therapeutic use KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Bone Marrow Transplantation -- adverse effects KW - Saliva -- secretion KW - Quinuclidines -- therapeutic use KW - Autoimmune Diseases -- complications KW - Xerostomia -- etiology KW - Xerostomia -- metabolism KW - Xerostomia -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70053453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Xerostomia%3A+causes+and+treatment.&rft.au=Wick%2C+Jeanette+Y&rft.aulast=Wick&rft.aufirst=Jeanette&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=985&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2008-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of nanoparticles for therapeutics. AN - 69086343; 18095846 AB - Nanotechnology offers many advantages to traditional drug design, delivery and medical diagnostics; however, nanomedicines present considerable challenges for preclinical development. Nanoparticle constructs intended for medical applications consist of a wide variety of materials, and their small size, unique physicochemical properties and biological activity often require modification of standard characterization techniques. A rational characterization strategy for nanomedicines includes physicochemical characterization, sterility and pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion [ADME]) and toxicity characterization, which includes both in vitro tests and in vivo animal studies. Here, we highlight progress for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy. JF - Nanomedicine (London, England) AU - Hall, Jennifer B AU - Dobrovolskaia, Marina A AU - Patri, Anil K AU - McNeil, Scott E AD - SAIC-Frederick Inc., Nanotechnology Characterization Laboratory, Advanced Technology Program, NCI-Frederick, 1050 Boyles St., Bldg. 469, Frederick, MD 21702, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 789 EP - 803 VL - 2 IS - 6 KW - Drug Carriers KW - 0 KW - Index Medicus KW - Nanomedicine -- trends KW - Chemistry, Pharmaceutical -- trends KW - Nanoparticles -- therapeutic use KW - Nanoparticles -- ultrastructure KW - Drug Carriers -- chemistry KW - Nanoparticles -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+pharmacotherapy&rft.atitle=Clinical+pharmacology+of+antifungal+agents+in+pediatric+patients.&rft.au=Chiou%2C+Christine+C%3BWalsh%2C+Thomas+J%3BGroll%2C+Andreas+H&rft.aulast=Chiou&rft.aufirst=Christine&rft.date=2007-10-01&rft.volume=8&rft.issue=15&rft.spage=2465&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+pharmacotherapy&rft.issn=1744-7666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A prospective study of red and processed meat intake in relation to cancer risk. AN - 69086300; 18076279 AB - Red meat and processed meat have been associated with carcinogenesis at several anatomic sites, but no prospective study has examined meat intake in relation to a range of malignancies. We investigated whether red or processed meat intake increases cancer risk at a variety of sites. The National Institutes of Health (NIH)-AARP (formerly the American Association for Retired Persons) Diet and Health Study is a cohort of approximately 500,000 people aged 50-71 y at baseline (1995-1996). Meat intake was estimated from a food frequency questionnaire administered at baseline. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals within quintiles of red and processed meat intake. During up to 8.2 y of follow-up, 53,396 incident cancers were ascertained. Statistically significant elevated risks (ranging from 20% to 60%) were evident for esophageal, colorectal, liver, and lung cancer, comparing individuals in the highest with those in the lowest quintile of red meat intake. Furthermore, individuals in the highest quintile of processed meat intake had a 20% elevated risk for colorectal and a 16% elevated risk for lung cancer. Both red and processed meat intakes were positively associated with cancers of the colorectum and lung; furthermore, red meat intake was associated with an elevated risk for cancers of the esophagus and liver. JF - PLoS medicine AU - Cross, Amanda J AU - Leitzmann, Michael F AU - Gail, Mitchell H AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, United States of America. crossa@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1 VL - 4 IS - 12 KW - Index Medicus KW - Sex Factors KW - Nutrition Assessment KW - Humans KW - Aged KW - Risk Assessment KW - Lung Neoplasms -- etiology KW - Prospective Studies KW - Risk Factors KW - Surveys and Questionnaires KW - Colorectal Neoplasms -- etiology KW - Incidence KW - Follow-Up Studies KW - Middle Aged KW - Esophageal Neoplasms -- etiology KW - Liver Neoplasms -- etiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Proportional Hazards Models KW - Meat Products -- adverse effects KW - Meat -- adverse effects KW - Neoplasms -- epidemiology KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+medicine&rft.atitle=A+prospective+study+of+red+and+processed+meat+intake+in+relation+to+cancer+risk.&rft.au=Cross%2C+Amanda+J%3BLeitzmann%2C+Michael+F%3BGail%2C+Mitchell+H%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Cross&rft.aufirst=Amanda&rft.date=2007-12-01&rft.volume=4&rft.issue=12&rft.spage=e325&rft.isbn=&rft.btitle=&rft.title=PLoS+medicine&rft.issn=1549-1676&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nutr Cancer. 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Dec;11(10):915-23 [11142526] Cancer Causes Control. 2000 Dec;11(10):965-74 [11142531] Carcinogenesis. 2001 Jan;22(1):199-202 [11159760] Oral Oncol. 2001 Feb;37(2):141-5 [11167140] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):559-62 [11352869] Nutr Rev. 2001 May;59(5):140-8 [11396694] Br J Cancer. 2001 Jul 6;85(1):46-54 [11437401] Cancer Causes Control. 2001 Aug;12(6):557-67 [11519764] Lung Cancer. 2001 Oct;34(1):37-46 [11557111] Am J Epidemiol. 2001 Dec 15;154(12):1089-99 [11744511] Ann Epidemiol. 1993 May;3(3):211-6 [8275191] J Natl Cancer Inst. 1994 Feb 16;86(4):281-6 [8158682] Cancer Causes Control. 1994 Mar;5(2):195-202 [8167267] Am J Public Health. 1994 Jul;84(7):1086-93 [8017530] Epidemiology. 1994 May;5(3):276-82 [8038241] Cancer Causes Control. 1994 Sep;5(5):422-32 [7999964] Cancer Causes Control. 1999 Oct;10(5):355-67 [10530605] Cancer Epidemiol Biomarkers Prev. 2005 Feb;14(2):512-20 [15734980] Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2261-5 [16172241] J Natl Cancer Inst. 2005 Oct 5;97(19):1458-65 [16204695] Cancer Res. 2005 Dec 15;65(24):11779-84 [16357191] J Natl Cancer Inst. 2006 Mar 1;98(5):345-54 [16507831] Am J Epidemiol. 2001 Dec 15;154(12):1119-25 [11744517] Int J Epidemiol. 2002 Feb;31(1):78-85 [11914299] Int J Cancer. 2002 Mar 20;98(3):480-2 [11920604] Am J Epidemiol. 2002 May 1;155(9):783-92 [11978580] Br J Cancer. 2002 Jul 1;87(1):37-42 [12085253] Int J Cancer. 2002 Jul 20;100(3):355-60 [12115553] Mutat Res. 2002 Sep 30;506-507:175-85 [12351157] Int J Cancer. 2002 Nov 20;102(3):207-11 [12397637] J Nutr. 2002 Nov;132(11 Suppl):3526S-3529S [12421882] Br J Cancer. 2002 Nov 18;87(11):1230-3 [12439711] Am J Epidemiol. 2003 Mar 1;157(5):434-45 [12615608] Eur J Cancer Prev. 2003 Apr;12(2):135-43 [12671537] Cancer Res. 2003 May 15;63(10):2358-60 [12750250] Am J Epidemiol. 2003 Jun 15;157(12):1115-25 [12796048] Am J Epidemiol. 2003 Jul 1;158(1):14-21; discussion 22-6 [12835281] Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):513-8 [8268766] J Natl Cancer Inst. 1995 May 3;87(9):652-61 [7752270] Biochem Biophys Res Commun. 1995 May 16;210(2):350-5 [7755610] J Urol. 1996 Mar;155(3):969-74 [8583620] Cancer Epidemiol Biomarkers Prev. 1995 Dec;4(8):895-9 [8634663] JAMA. 1996 May 1;275(17):1315-21 [8614116] Lung Cancer. 1996 Jun;14(2-3):195-205 [8794403] Cancer Epidemiol Biomarkers Prev. 1996 Mar;5(3):161-6 [8833615] Princess Takamatsu Symp. 1995;23:232-9 [8844814] Int J Cancer. 1997 Mar 28;71(1):14-9 [9096659] Nutr Cancer. 1997;27(3):256-60 [9101555] Med Sci Sports Exerc. 1997 Jun;29(6 Suppl):S1-205 [9243481] Cancer Res. 1997 Nov 15;57(22):5077-85 [9371506] Int J Cancer. 1997 Nov 27;73(5):634-8 [9398038] Carcinogenesis. 1998 Jan;19(1):117-24 [9472702] Int J Cancer. 1998 May 29;76(5):659-64 [9610722] Hepatology. 1998 Jun;27(6):1563-6 [9620327] Food Chem Toxicol. 1998 Apr;36(4):279-87 [9651044] Leuk Res. 1998 May;22(5):445-52 [9652731] J Med Microbiol. 1998 May;47(5):407-16 [9879941] Eur J Cancer Prev. 1998 Dec;7(6):455-60 [9926293] Cancer Epidemiol Biomarkers Prev. 1999 Jan;8(1):25-34 [9950236] Toxicol Lett. 1998 Dec 28;102-103:441-6 [10022293] Int J Cancer. 1999 Mar 15;80(6):852-6 [10074917] Cancer Causes Control. 1998 Dec;9(6):621-30 [10189048] Am J Epidemiol. 1999 May 15;149(10):925-32 [10342801] Br J Cancer. 1999 Jun;80(7):1107-13 [10362125] Gut. 1999 Jul;45(1):45-50 [10369703] Br J Cancer. 1999 May;80(3-4):591-7 [10408871] Cancer Lett. 1999 Sep 1;143(2):149-55 [10503895] Cancer Causes Control. 2003 Jun;14(5):427-38 [12946037] Cancer Epidemiol Biomarkers Prev. 2003 Sep;12(9):940-4 [14504209] Neuroepidemiology. 2004 Jan-Apr;23(1-2):78-84 [14739572] Am J Epidemiol. 2004 Mar 1;159(5):454-66 [14977641] Int J Cancer. 2004 Jun 20;110(3):424-8 [15095309] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Comment In: PLoS Med. 2007 Dec;4(12):e345 [18076281] Comment On: PLoS Med. 2007 Dec;4(12):e354 [18076283] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pulmonary lesions in female Harlan Sprague-Dawley rats following two-year oral treatment with dioxin-like compounds. AN - 69079717; 18098034 AB - Dioxin and dioxin-related compounds have been associated with high incidences of pulmonary dysfunctions and/or cancers in humans. To evaluate the relative potencies of effects of these compounds, the National Toxicology Program completed a series of two-year bioassays which were conducted using female Harlan Sprague-Dawley rats. The rats were treated orally for up to 2 years with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 3,3',4,4',5-pentachlorobiphenyl (PCB126), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and a ternary mixture of TCDD, PCB126 and PeCDF. In addition to treatment-related effects reported in other organs, a variety of pulmonary lesions were observed that were related to exposure. Pulmonary CYP1A1-associated 7-ethoxyresorufin-O-deethylase (EROD) activity was increased in all dosed groups. The most common non-neoplastic lesions, which occurred in all studies, were bronchiolar metaplasia and squamous metaplasia of the alveolar epithelium. Cystic keratinizing epithelioma was the most commonly observed neoplasm which occurred in all studies. A low incidence of squamous cell carcinoma was associated only with PCB126 treatment. Potential mechanisms leading to altered differentiation and/or proliferation of bronchiolar and alveolar epithelia may be through CYP1A1 induction or disruption of retinoid metabolism. JF - Toxicologic pathology AU - Walker, Nigel J AU - Yoshizawa, Katsuhiko AU - Miller, Rodney A AU - Brix, Amy E AU - Sells, Donald M AU - Jokinen, Micheal P AU - Wyde, Michael E AU - Easterling, Michael AU - Nyska, Abraham AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. walker3@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 880 EP - 889 VL - 35 IS - 7 SN - 0192-6233, 0192-6233 KW - Benzofurans KW - 0 KW - Polychlorinated Dibenzodioxins KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - 3,4,5,3',4'-pentachlorobiphenyl KW - TSH69IA9XF KW - 2,3,4,7,8-pentachlorodibenzofuran KW - U4C2RV3124 KW - Index Medicus KW - Rats KW - Administration, Oral KW - Animals KW - Rats, Sprague-Dawley KW - Metaplasia KW - Time Factors KW - Female KW - Cytochrome P-450 CYP1A1 -- physiology KW - Polychlorinated Biphenyls -- toxicity KW - Polychlorinated Dibenzodioxins -- toxicity KW - Lung -- drug effects KW - Lung -- pathology KW - Benzofurans -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69079717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Pulmonary+lesions+in+female+Harlan+Sprague-Dawley+rats+following+two-year+oral+treatment+with+dioxin-like+compounds.&rft.au=Walker%2C+Nigel+J%3BYoshizawa%2C+Katsuhiko%3BMiller%2C+Rodney+A%3BBrix%2C+Amy+E%3BSells%2C+Donald+M%3BJokinen%2C+Micheal+P%3BWyde%2C+Michael+E%3BEasterling%2C+Michael%3BNyska%2C+Abraham&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2007-12-01&rft.volume=35&rft.issue=7&rft.spage=880&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-21 N1 - Date created - 2007-12-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Appl Pharmacol. 1996 Sep;140(1):173-9 [8806883] Toxicol Appl Pharmacol. 1995 Oct;134(2):222-8 [7570598] Annu Rev Cell Dev Biol. 1996;12:55-89 [8970722] IARC Monogr Eval Carcinog Risks Hum. 1997;69:1-631 [9379504] Teratog Carcinog Mutagen. 1997-1998;17(4-5):249-56 [9508734] Exp Toxicol Pathol. 1997 Dec;49(6):433-46 [9495643] Toxicol Sci. 1998 Jan;41(1):62-76 [9520342] Toxicol Pathol. 1998 Mar-Apr;26(2):298-300 [9547872] Environ Health Perspect. 1998 Dec;106(12):775-92 [9831538] Drug Metab Dispos. 1998 Dec;26(12):1194-8 [9860927] Fukuoka Igaku Zasshi. 1999 May;90(5):231-7 [10396879] Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2004 Jul;148(1):3-10 [15523539] Toxicol Sci. 2005 Jan;83(1):64-77 [15509667] Environ Health Perspect. 2005 Jan;113(1):43-8 [15626646] Toxicol Pathol. 2005;33(3):371-7 [15805076] Toxicol Sci. 2005 May;85(1):594-606 [15716480] Natl Toxicol Program Tech Rep Ser. 2006 Jan;(520):4-246 [16628245] Mol Nutr Food Res. 2006 Oct;50(10):934-44 [16977594] Natl Toxicol Program Tech Rep Ser. 2006 Sep;(525):1-198 [17160103] Toxicol Pathol. 2007 Jan;35(1):170-7 [17325986] Natl Toxicol Program Tech Rep Ser. 2006 Sep;(526):1-180 [17342195] Toxicol Appl Pharmacol. 2000 Jun 15;165(3):184-94 [10860868] Toxicol Pathol. 2000 Nov-Dec;28(6):761-9 [11127289] Am J Epidemiol. 2001 Jun 1;153(11):1031-44 [11390319] Toxicol Sci. 2001 Jul;62(1):166-75 [11399804] Am J Epidemiol. 2001 Sep 1;154(5):451-8 [11532787] Teratog Carcinog Mutagen. 2001;21(6):395-403 [11746253] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] Toxicol Sci. 2002 Oct;69(2):409-23 [12377990] Annu Rev Pharmacol Toxicol. 2003;43:309-34 [12540743] Arch Toxicol. 2003 Jul;77(7):371-83 [12851740] Ind Health. 2003 Jul;41(3):127-38 [12916742] Chemosphere. 2004 Mar;54(9):1329-36 [14659426] Life Sci. 2004 Jan 9;74(8):1039-49 [14672759] Toxicol Pathol. 2004 Jan-Feb;32(1):41-9 [14713547] Environ Health Perspect. 2004 Jun;112(8):903-9 [15175180] J Biol Chem. 2004 Jun 4;279(23):23847-50 [15028720] Cardiovasc Toxicol. 2003;3(4):299-310 [14734827] Toxicol Pathol. 2004 May-Jun;32(3):333-7 [15204975] Regul Toxicol Pharmacol. 2004 Aug;40(1):28-41 [15265604] Biometrics. 1977 Jun;33(2):386-9 [884197] Toxicol Appl Pharmacol. 1978 Nov;46(2):279-303 [734660] J Toxicol Environ Health. 1980 Jan;6(1):27-43 [7381973] Annu Rev Pharmacol Toxicol. 1982;22:517-54 [6282188] Prog Clin Biol Res. 1984;137:19-30 [6425851] Biometrics. 1986 Mar;42(1):183-6 [3719054] Environ Res. 1986 Oct;41(1):144-67 [3757966] Dev Toxicol Environ Sci. 1986;13:459-70 [2435503] Am J Physiol. 1990 Aug;259(2 Pt 1):L38-46 [2200283] N Engl J Med. 1991 Jan 24;324(4):212-8 [1985242] J Biochem Toxicol. 1990 Winter;5(4):211-9 [2096217] Fukuoka Igaku Zasshi. 1991 May;82(5):251-5 [1916596] J Nutr Sci Vitaminol (Tokyo). 1991 Apr;37(2):117-38 [1919800] Cancer Res. 1992 Nov 15;52(22):6144-52 [1384955] Mol Pharmacol. 1993 Nov;44(5):911-7 [8246913] Cancer Res. 1994 Apr 1;54(7 Suppl):1987s-1990s [8137325] Occup Environ Med. 1994 Jul;51(7):479-86 [8044248] Toxicol Appl Pharmacol. 1994 Aug;127(2):209-21 [8048064] Carcinogenesis. 1994 Oct;15(10):2245-8 [7955061] Chemosphere. 1994 Nov-Dec;29(9-11):2309-13 [7850379] Toxicol Appl Pharmacol. 1995 May;132(1):1-13 [7747272] Carcinogenesis. 1995 Jun;16(6):1345-9 [7788853] Toxicol Pathol. 1996 Sep-Oct;24(5):564-72 [8923677] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The naphthoquinones, vitamin K3 and its structural analogue plumbagin, are substrates of the multidrug resistance linked ATP binding cassette drug transporter ABCG2. AN - 69078521; 18065489 AB - Vitamin K3 (menadione; 2-methyl-1,4-naphthoquinone) is a structural precursor of vitamins K1 and K2, which are essential for blood clotting. The naturally occurring structural analogue of this vitamin, plumbagin (5-hydroxy-menadione), is known to modulate cellular proliferation, apoptosis, carcinogenesis, and radioresistance. We here report that both vitamin K3 and plumbagin are substrates of the multidrug resistance-linked ATP binding cassette drug transporter, ABCG2. Vitamin K3 and plumbagin specifically inhibited the ABCG2-mediated efflux of mitoxantrone but did not have any effect on the ABCB1-mediated efflux of rhodamine 123. This inhibition of ABCG2 function was due to their interaction at the substrate-binding site(s). Vitamin K3 and plumbagin inhibited the binding of [(125)I]iodoarylazidoprazosin, a substrate of ABCG2, to this transporter in a concentration-dependent manner with IC(50) values of 7.3 and 22.6 micromol/L, respectively, but had no effect on the binding of the photoaffinity analogue to ABCB1. Both compounds stimulated ABCG2-mediated ATP hydrolysis and also inhibited the mitoxantrone-stimulated ATPase activity of the ABCG2 transporter, but did not have any significant effect on the ATPase activity of ABCB1. In a cytotoxicity assay, ABCG2-expressing HEK cells were 2.8- and 2.3-fold resistant to plumbagin and vitamin K3, respectively, compared with the control cells, suggesting that they are substrates of this transporter. Collectively, these data show for the first time that vitamin K3 is a substrate of the ABCG2 transporter. Thus, ABCG2 may have a role in the regulation of vitamin K3 levels in the body. In addition, vitamin K3 and its structural derivative, plumbagin, could potentially be used to modulate ABCG2 function. JF - Molecular cancer therapeutics AU - Shukla, Suneet AU - Wu, Chung-Pu AU - Nandigama, Krishnamachary AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, National Cancer Institute, MSC 4254, 37 Convent Drive, Bethesda, MD 20892-4256, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3279 EP - 3286 VL - 6 IS - 12 Pt 1 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Naphthoquinones KW - Neoplasm Proteins KW - Photoaffinity Labels KW - Cholecalciferol KW - 1C6V77QF41 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Mitoxantrone KW - BZ114NVM5P KW - plumbagin KW - YAS4TBQ4OQ KW - Index Medicus KW - Humans KW - Adenosine Triphosphate -- metabolism KW - Mitoxantrone -- pharmacology KW - Hydrolysis KW - Cell Line KW - Drug Resistance, Multiple KW - Cholecalciferol -- pharmacology KW - ATP-Binding Cassette Transporters -- metabolism KW - Naphthoquinones -- pharmacology KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69078521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=The+naphthoquinones%2C+vitamin+K3+and+its+structural+analogue+plumbagin%2C+are+substrates+of+the+multidrug+resistance+linked+ATP+binding+cassette+drug+transporter+ABCG2.&rft.au=Shukla%2C+Suneet%3BWu%2C+Chung-Pu%3BNandigama%2C+Krishnamachary%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2007-12-01&rft.volume=6&rft.issue=12+Pt+1&rft.spage=3279&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-19 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2515-20 [10716986] Mol Cell Biol. 2007 Feb;27(4):1247-53 [17145775] Clin Cancer Res. 2000 Nov;6(11):4186-91 [11106230] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Cancer Res. 2001 Apr 15;61(8):3458-64 [11309308] Biochim Biophys Acta. 2001 Jun 6;1512(2):171-82 [11406094] Clin Cancer Res. 2002 Feb;8(2):582-8 [11839680] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Clin Cancer Res. 2003 Feb;9(2):650-6 [12576431] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Mol Pharmacol. 2004 Mar;65(3):675-84 [14978246] Apoptosis. 2004 Mar;9(2):223-33 [15004519] Biochem Pharmacol. 2004 Nov 15;68(10):2043-52 [15476675] Anal Biochem. 1973 Dec;56(2):502-14 [4128882] Science. 1986 May 2;232(4750):643-5 [3457471] Biochem Pharmacol. 1991 May 1;41(9):1283-92 [2018560] Cancer Lett. 1992 Jan 10;61(2):147-56 [1730138] Cancer Res. 1993 Oct 1;53(19):4595-602 [8402633] Lancet. 1995 Jan 28;345(8944):229-34 [7823718] Cancer Chemother Pharmacol. 1995;36(4):293-8 [7628048] Invest New Drugs. 1995;13(2):157-62 [8617579] Br J Obstet Gynaecol. 1996 Nov;103(11):1078-84 [8916992] J Pharm Pharmacol. 1996 Nov;48(11):1128-32 [8961159] Pediatrics. 1997 Jan;99(1):88-92 [8989344] Anticancer Drugs. 1997 Feb;8(2):125-40 [9073309] Indian J Physiol Pharmacol. 1997 Apr;41(2):171-5 [9142565] Br J Radiol. 1997 Jun;70(834):599-602 [9227253] Anticancer Drugs. 1998 Jun;9(5):437-48 [9660542] Methods Enzymol. 1998;292:504-14 [9711578] Cancer Res. 1998 Dec 1;58(23):5337-9 [9850061] Indian J Exp Biol. 1998 Sep;36(9):891-5 [9854429] Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15665-70 [9861027] J Natl Cancer Inst. 1999 Mar 3;91(5):429-33 [10070941] Nat Med. 2005 Feb;11(2):127-9 [15685169] Int J Oncol. 2005 Mar;26(3):713-20 [15703828] J Biol Chem. 2006 Jun 23;281(25):17023-33 [16624823] J Pharmacol Exp Ther. 2006 Aug;318(2):484-94 [16632641] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Biochem Pharmacol. 2006 Sep 14;72(6):671-80 [16828058] J Urol. 2006 Oct;176(4 Pt 1):1642-7 [16952707] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Mol Cancer Ther. 2006 Dec;5(12):3209-21 [17172425] Int J Oncol. 2000 Aug;17(2):323-8 [10891542] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for dual mode of action of a thiosemicarbazone, NSC73306: a potent substrate of the multidrug resistance linked ABCG2 transporter. AN - 69076736; 18089722 AB - Multidrug resistance due to reduced drug accumulation is a phenomenon predominantly caused by the overexpression of members of the ATP-binding cassette (ABC) transporters, including ABCB1 (P-glycoprotein), ABCG2, and several ABCC family members [multidrug resistance-associated protein (MRP)]. We previously reported that a thiosemicarbazone derivative, NSC73306, is cytotoxic to carcinoma cells that overexpress functional P-glycoprotein, and it resensitizes these cells to chemotherapeutics. In this study, we investigated the effect of NSC73306 on cells overexpressing other ABC drug transporters, including ABCG2, MRP1, MRP4, and MRP5. Our findings showed that NSC73306 is not more toxic to cells that overexpress these transporters compared with their respective parental cells, and these transporters do not confer resistance to NSC73306 either. In spite of this, we observed that NSC73306 is a transport substrate for ABCG2 that can effectively inhibit ABCG2-mediated drug transport and reverse resistance to both mitoxantrone and topotecan in ABCG2-expressing cells. Interactions between NSC73306 and the ABCG2 drug-binding site(s) were confirmed by its stimulatory effect on ATPase activity (140-150 nmol/L concentration required for 50% stimulation) and by inhibition of [(125)I]iodoarylazidoprazosin photolabeling (50% inhibition at 250-400 nmol/L) of the substrate-binding site(s). Overall, NSC73306 seems to be a potent modulator of ABCG2 that does not interact with MRP1, MRP4, or MRP5. Collectively, these data suggest that NSC73306 can potentially be used, due to its dual mode of action, as an effective agent to overcome drug resistance by eliminating P-glycoprotein-overexpressing cells and by acting as a potent modulator that resensitizes ABCG2-expressing cancer cells to chemotherapeutics. JF - Molecular cancer therapeutics AU - Wu, Chung-Pu AU - Shukla, Suneet AU - Calcagno, Anna Maria AU - Hall, Matthew D AU - Gottesman, Michael M AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4256, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3287 EP - 3296 VL - 6 IS - 12 Pt 1 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Indoles KW - NSC73306 KW - Neoplasm Proteins KW - Photoaffinity Labels KW - Mitoxantrone KW - BZ114NVM5P KW - Index Medicus KW - Blotting, Western KW - Humans KW - Mitoxantrone -- pharmacokinetics KW - Cell Line, Tumor KW - ATP-Binding Cassette Transporters -- metabolism KW - Indoles -- metabolism KW - Indoles -- pharmacology KW - Neoplasm Proteins -- metabolism KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Evidence+for+dual+mode+of+action+of+a+thiosemicarbazone%2C+NSC73306%3A+a+potent+substrate+of+the+multidrug+resistance+linked+ABCG2+transporter.&rft.au=Wu%2C+Chung-Pu%3BShukla%2C+Suneet%3BCalcagno%2C+Anna+Maria%3BHall%2C+Matthew+D%3BGottesman%2C+Michael+M%3BAmbudkar%2C+Suresh+V&rft.aulast=Wu&rft.aufirst=Chung-Pu&rft.date=2007-12-01&rft.volume=6&rft.issue=12+Pt+1&rft.spage=3287&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-19 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Pharmacol Sci. 2006 Jan;27(1):10-6 [16337280] FEBS J. 2005 Sep;272(18):4725-40 [16156793] Cancer Res. 2006 May 1;66(9):4808-15 [16651436] Physiol Rev. 2006 Jul;86(3):849-99 [16816140] Biochemistry. 2006 Jul 25;45(29):8940-51 [16846237] Mol Cancer Ther. 2006 Aug;5(8):1995-2006 [16928820] Physiol Rev. 2006 Oct;86(4):1179-236 [17015488] Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14901-6 [17003122] Br J Pharmacol. 2006 Nov;149(5):506-15 [16981002] Cancer Metastasis Rev. 2007 Mar;26(1):39-57 [17323127] Cancer Res. 2007 May 1;67(9):4373-81 [17483351] J Exp Ther Oncol. 2004 Apr;4(1):25-35 [15255290] Cancer Res. 2000 May 15;60(10):2589-93 [10825126] Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7476-81 [10840050] J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6 [11036110] Cancer Res. 2000 Oct 15;60(20):5761-6 [11059771] Clin Cancer Res. 2001 Jan;7(1):145-52 [11205902] Biochim Biophys Acta. 2001 Jun 6;1512(2):171-82 [11406094] Cancer Res. 2001 Sep 15;61(18):6635-9 [11559526] Clin Cancer Res. 2002 Jan;8(1):22-8 [11801536] J Bioenerg Biomembr. 2001 Dec;33(6):453-8 [11804186] Nat Rev Cancer. 2002 Jan;2(1):48-58 [11902585] Annu Rev Biochem. 2002;71:537-92 [12045106] Biochemistry. 2002 Aug 6;41(31):10123-32 [12146977] Mol Pharmacol. 2002 Dec;62(6):1321-31 [12435799] Biochemistry. 2002 Nov 26;41(47):13989-4000 [12437356] Cancer Res. 2003 Jul 15;63(14):4048-54 [12874005] Int J Cancer. 2003 Dec 10;107(5):757-63 [14566825] Br J Cancer. 2003 Nov 17;89(10):1971-8 [14612912] Nat Rev Drug Discov. 2006 Mar;5(3):219-34 [16518375] Cancer Res. 2004 Feb 15;64(4):1242-6 [14973080] Mini Rev Med Chem. 2004 Jan;4(1):31-9 [14754441] J Pharmacol Exp Ther. 2004 Aug;310(2):836-42 [15075385] Cancer Cell. 2004 Aug;6(2):129-37 [15324696] Clin Colorectal Cancer. 2004 Sep;4(3):163-80 [15377400] Cancer Res. 1981 May;41(5):1967-72 [7214365] J Biol Chem. 1990 Jun 15;265(17):10073-80 [1972154] Pharmazie. 1993 Sep;48(9):659-66 [8234398] J Natl Cancer Inst. 1994 Jan 19;86(2):110-7 [7903701] Cancer Res. 1994 Jan 15;54(2):357-61 [8275468] Curr Opin Genet Dev. 1996 Oct;6(5):610-7 [8939727] Biol Pharm Bull. 1996 Nov;19(11):1518-20 [8951178] J Biol Chem. 1997 Aug 22;272(34):21160-6 [9261121] Methods Enzymol. 1998;292:504-14 [9711578] Cancer Res. 1999 Jan 1;59(1):8-13 [9892175] Cancer Res. 1999 Sep 15;59(18):4559-63 [10493507] J Biol Chem. 2004 Nov 19;279(47):48855-64 [15364914] Biochim Biophys Acta. 2005 Feb 1;1668(1):53-63 [15670731] J Cell Sci. 2005 Apr 1;118(Pt 7):1417-26 [15769853] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The relationship of silicone breast implants and cancer at other sites. AN - 69076487; 18090818 AB - Although most attention regarding the effects of silicone breast implants on cancer risk has focused on breast cancer, there have also been concerns regarding effects on other cancers. This includes malignancies that could occur as a result of foreign-body carcinogenesis (sarcomas) or immune alterations (hematopoietic malignancies), or cancers suggested as possibly elevated on the basis of previous epidemiologic studies (cancers of the cervix, vulva, lung, and brain). Searches of the English language literature on the topic of silicone breast implants and cancer risk were conducted and reviewed to determine relationships that might have etiologic relevance. Epidemiologic studies provide no support for an increased risk of either sarcoma or multiple myeloma among breast implant recipients, disputing clinical and laboratory findings suggesting such a link. Although a number of epidemiologic studies have demonstrated elevated risks of cervical, vulvar, and lung cancers among breast implant patients, it is likely that these excesses relate more to lifestyle characteristics (e.g., cigarette smoking, sexual behavior) than to the effects of the implants. Brain cancer excesses, suggested in one study, have not been confirmed in either an update of the mortality experience in this study or on the basis of other investigations. At present, there is no convincing evidence that breast implants alter the risk of nonbreast malignancies. Breast implant patients should continue to be monitored for longer term risks and to assess whether cancer risk is influenced by various patient and implant characteristics. JF - Plastic and reconstructive surgery AU - Brinton, Louise A AD - Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Md. 20852-7234, USA. brinton@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 94S EP - 102S VL - 120 IS - 7 Suppl 1 KW - Silicone Gels KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Female KW - Neoplasms -- epidemiology KW - Breast Implants -- statistics & numerical data KW - Hematologic Neoplasms -- epidemiology KW - Sarcoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69076487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Plastic+and+reconstructive+surgery&rft.atitle=The+relationship+of+silicone+breast+implants+and+cancer+at+other+sites.&rft.au=Brinton%2C+Louise+A&rft.aulast=Brinton&rft.aufirst=Louise&rft.date=2007-12-01&rft.volume=120&rft.issue=7+Suppl+1&rft.spage=94S&rft.isbn=&rft.btitle=&rft.title=Plastic+and+reconstructive+surgery&rft.issn=1529-4242&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-17 N1 - Date created - 2007-12-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bilateral ptosis and supranuclear downgaze paralysis. AN - 69073005; 18094864 AB - The purpose of this article is to highlight an uncommon combination of supranuclear downward gaze paralysis with bilateral eyelid ptosis in a 53-year-old man with a radiation induced midbrain tumor and to discuss the aspects regarding the centers and pathways that mediate supranuclear vertical gaze movements. JF - Arquivos de neuro-psiquiatria AU - Maranhão-Filho, Péricles AU - Campos, João Carlos S AU - Lima, Marco A AD - Department of Neurosurgery, Brazilian National Cancer Institute, Avenida Canal de Marapendi 1680, Rio de Janeiro, RJ, Brazil. pmaranhaofilho@gmail.com Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1007 EP - 1009 VL - 65 IS - 4A SN - 0004-282X, 0004-282X KW - Index Medicus KW - Magnetic Resonance Imaging KW - Fatal Outcome KW - Humans KW - Aged KW - Middle Aged KW - Ophthalmoplegia -- etiology KW - Male KW - Female KW - Neoplasms, Radiation-Induced -- complications KW - Astrocytoma -- complications KW - Brain Neoplasms -- complications KW - Blepharoptosis -- etiology KW - Astrocytoma -- diagnosis KW - Brain Neoplasms -- diagnosis KW - Neoplasms, Radiation-Induced -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69073005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Drug-drug+interactions+affected+by+the+transporter+protein%2C+P-glycoprotein+%28ABCB1%2C+MDR1%29&rft.au=Aszalos%2C+A&rft.aulast=Aszalos&rft.aufirst=A&rft.date=2007-10-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2007.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-02 N1 - Date created - 2007-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Meat and meat-mutagen intake and pancreatic cancer risk in the NIH-AARP cohort. AN - 69070615; 18086772 AB - Meat intake, particularly red meat, has been positively associated with pancreatic cancer in some epidemiologic studies. Detailed meat-cooking methods and related mutagens formed in meat cooked at high temperatures have not been evaluated prospectively as risk factors for this malignancy. We investigated the association between meat, meat-cooking methods, meat-mutagen intake, and exocrine pancreatic cancer in the NIH-American Association of Retired Persons (NIH-AARP) Diet and Health Study cohort of 537,302 individuals, aged 50 to 71 years, with complete baseline dietary data (1995-1996) ascertained from a food frequency questionnaire. A meat-cooking module was completed by 332,913 individuals 6 months after baseline. During 5 years of follow-up, 836 incident pancreatic cancer cases (555 men, 281 women) were identified. Four hundred and fifty-nine cases had complete meat module data. We used Cox proportional hazard models to calculate hazard ratios (HR) and 95% confidence intervals (CI). Total, red, and high-temperature cooked meat intake was positively associated with pancreatic cancer among men (fifth versus first quintile: HR, 1.41, 95% CI, 1.08-1.83, P trend = 0.001; HR, 1.42, 95% CI, 1.05-1.91, P trend = 0.01; and HR, 1.52, 95% CI, 1.12-2.06, P trend = 0.005, respectively), but not women. Men showed significant 50% increased risks for the highest tertile of grilled/barbecued and broiled meat and significant doubling of risk for the highest quintile of overall meat-mutagenic activity (P trends < 0.01). The fifth quintile of the heterocyclic amine, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline intake showed a significant 29% (P trend = 0.006) increased risk in men and women combined. These findings support the hypothesis that meat intake, particularly meat cooked at high temperatures and associated mutagens, may play a role in pancreatic cancer development. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Stolzenberg-Solomon, Rachael Z AU - Cross, Amanda J AU - Silverman, Debra T AU - Schairer, Catherine AU - Thompson, Frances E AU - Kipnis, Victor AU - Subar, Amy F AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Sinha, Rashmi AD - National Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health Human Services, Rockville, MD 20852, USA. rs221z@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2664 EP - 2675 VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Mutagens KW - 0 KW - Index Medicus KW - United States KW - Sex Factors KW - Risk Factors KW - Humans KW - National Institutes of Health (U.S.) KW - Aged KW - Middle Aged KW - Male KW - Female KW - Meat KW - Mutagens -- adverse effects KW - Cooking -- methods KW - Diet KW - Pancreatic Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69070615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Meat+and+meat-mutagen+intake+and+pancreatic+cancer+risk+in+the+NIH-AARP+cohort.&rft.au=Stolzenberg-Solomon%2C+Rachael+Z%3BCross%2C+Amanda+J%3BSilverman%2C+Debra+T%3BSchairer%2C+Catherine%3BThompson%2C+Frances+E%3BKipnis%2C+Victor%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BSinha%2C+Rashmi&rft.aulast=Stolzenberg-Solomon&rft.aufirst=Rachael&rft.date=2007-12-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ovarian cancer and menopausal hormone therapy: more data and new questions. AN - 69069885; 18086754 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Lacey, James V AD - Jr., Division of Cancer Epidemiology and Genetics, National Cancer Institute, MSC 7234, 6120 Executive Boulevard, Rockville, MD 20852-7234. jimlacey@nih.gov. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2524 EP - 2525 VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Time Factors KW - Female KW - Hormone Replacement Therapy -- adverse effects KW - Ovarian Neoplasms -- chemically induced KW - Menopause UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69069885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Ovarian+cancer+and+menopausal+hormone+therapy%3A+more+data+and+new+questions.&rft.au=Lacey%2C+James+V&rft.aulast=Lacey&rft.aufirst=James&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2524&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2548-56 [18086757] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical and enzymatic oxidation of furosemide: formation of pyridinium salts. AN - 69069773; 17914885 AB - Furosemide (Lasix) is frequently used in the treatment of cardiovascular and renal disease. Only one metabolite, furosemide glucuronide, has ever been identified. Oxidation of furosemide by cytochrome P450 has been demonstrated, but the metabolite(s) has never been identified. The oxidation of furosemide by dimethyldioxirane in acetone and by liver microsomal incubations was explored in this study. The first observable product from dimethyldioxirane oxidation was a ring-expanded enone resulting from an intramolecular condensation of the aldehyde group of the enonal, the secondary amine, and the carboxylic acid in a Mannich-like reaction. Keto-enol tautomerization and opening of the lactone gave a stable pyridinium salt. The pyridinium salt was also observed in the microsomal incubations of furosemide. The presence of an internal nucleophile in furosemide may have a significant effect on the toxicology and possibly the pharmacology of this furan. JF - Chemical research in toxicology AU - Chen, Ling-Jen AU - Burka, Leo T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. ljferguson@lrri.org Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1741 EP - 1744 VL - 20 IS - 12 SN - 0893-228X, 0893-228X KW - Diuretics KW - 0 KW - Epoxy Compounds KW - Pyridinium Compounds KW - Salts KW - dimethyldioxirane KW - 74087-85-7 KW - Furosemide KW - 7LXU5N7ZO5 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Molecular Structure KW - Spectrometry, Mass, Electrospray Ionization KW - Animals KW - Rats, Inbred F344 KW - Biotransformation KW - Epoxy Compounds -- chemistry KW - Male KW - Chromatography, High Pressure Liquid KW - Magnetic Resonance Spectroscopy KW - Diuretics -- metabolism KW - Pyridinium Compounds -- chemistry KW - Pyridinium Compounds -- metabolism KW - Diuretics -- chemistry KW - Microsomes, Liver -- enzymology KW - Microsomes, Liver -- drug effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Furosemide -- chemistry KW - Furosemide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69069773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Chemical+and+enzymatic+oxidation+of+furosemide%3A+formation+of+pyridinium+salts.&rft.au=Chen%2C+Ling-Jen%3BBurka%2C+Leo+T&rft.aulast=Chen&rft.aufirst=Ling-Jen&rft.date=2007-12-01&rft.volume=20&rft.issue=12&rft.spage=1741&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe. AN - 69061901; 17947404 AB - Currently, no transposon-based method for the mutagenesis of Schizosaccharomyces pombe exists. We have developed such a system based on the introduction of the hermes transposon from the housefly into S. pombe. This system efficiently disrupts open reading frames and allows the insertion sites to be readily identified. JF - Genetics AU - Evertts, Adam G AU - Plymire, Christopher AU - Craig, Nancy L AU - Levin, Henry L AD - Section of Eukaryotic Transposable Elements, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2519 EP - 2523 VL - 177 IS - 4 SN - 0016-6731, 0016-6731 KW - DNA Transposable Elements KW - 0 KW - Index Medicus KW - Animals KW - Open Reading Frames KW - Binding Sites KW - Schizosaccharomyces -- genetics KW - Houseflies -- genetics KW - Mutagenesis, Insertional -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69061901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=The+hermes+transposon+of+Musca+domestica+is+an+efficient+tool+for+the+mutagenesis+of+Schizosaccharomyces+pombe.&rft.au=Evertts%2C+Adam+G%3BPlymire%2C+Christopher%3BCraig%2C+Nancy+L%3BLevin%2C+Henry+L&rft.aulast=Evertts&rft.aufirst=Adam&rft.date=2007-12-01&rft.volume=177&rft.issue=4&rft.spage=2519&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1995 Jun;15(6):3310-7 [7760826] Gene. 1993 Jan 15;123(1):131-6 [8422997] Yeast. 1998 Jul;14(10):943-51 [9717240] Nature. 2004 Dec 23;432(7020):995-1001 [15616554] Genetics. 2005 Mar;169(3):1779-85 [15654093] Yeast. 2005 May;22(7):583-91 [15942936] Nature. 2005 Jul 14;436(7048):221-6 [16015321] Cytogenet Genome Res. 2005;110(1-4):566-74 [16093710] Cell. 2005 Aug 12;122(3):473-83 [16096065] Nucleic Acids Res. 1993 Jun 25;21(12):2955-6 [8332516] Nature. 1999 Nov 25;402(6760):413-8 [10586881] Nucleic Acids Res. 2000 Dec 1;28(23):4709-16 [11095681] Nature. 2002 Feb 21;415(6874):871-80 [11859360] Eukaryot Cell. 2002 Feb;1(1):44-55 [12455970] Mol Genet Genomics. 2003 Mar;268(6):779-90 [12655404] Genetics. 2004 Jun;167(2):761-81 [15238527] Mol Cell Biol. 1986 Nov;6(11):3643-51 [3540598] Science. 1996 Dec 20;274(5295):2069-74 [8953036] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gynecologic and hormonal effects of raloxifene in premenopausal women. AN - 69058943; 17662283 AB - To assess the effects of raloxifene on the ovaries, uterus, and serum hormone levels in premenopausal women. Prospective study comparing pretreatment findings with findings for those on treatment. Government research hospital. Thirty women 35 to 47 years of age who were at high risk of breast cancer and had regular, ovulatory menstrual cycles. Raloxifene (60 mg) and calcium (1,200 mg) daily for 2 years. Sonographic evidence of ovarian stimulation (>or=2 corpora lutea, or follicular cysts of >2 cm, or single follicular cyst of >3 cm). Changes in endometrial thickness, fibroid size, hormone levels, and menstrual-cycle length. Fifteen subjects developed some cycles with asymptomatic ovarian stimulation, and 9 developed benign endometrial polyps, compared with 2 subjects and 1 subject pretreatment, respectively. Uterine fibroid size was unchanged during raloxifene use in 16 subjects with fibroids. On treatment, E(2) levels increased significantly only during the follicular phase, with peak E(2) levels significantly higher in cycles showing ovarian stimulation compared with those without. Sex hormone-binding globulin increased, but levels of LH, FSH, P, DHEAS, and T did not. Endometrial thickness and cycle length were unchanged. Premenopausal subjects receiving raloxifene showed sonographic and hormonal evidence of ovarian stimulation. Endometrial thickness, cycle length, and fibroid size were unchanged. Benign asymptomatic endometrial polyps developed in some. JF - Fertility and sterility AU - Premkumar, Ahalya AU - Venzon, David J AU - Avila, Nilo AU - Johnson, Diane V AU - Remaley, Alan T AU - Forman, Michele R AU - Eng-Wong, Jennifer AU - Zujewski, JoAnne AU - Stratton, Pamela AD - Department of Diagnostic Radiology, Warren G. Magnuson Clinical Center, Bethesda, Maryland, USA. ps79c@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1637 EP - 1644 VL - 88 IS - 6 KW - Gonadal Steroid Hormones KW - 0 KW - Selective Estrogen Receptor Modulators KW - Raloxifene Hydrochloride KW - 4F86W47BR6 KW - Dehydroepiandrosterone Sulfate KW - 57B09Q7FJR KW - Calcium Carbonate KW - H0G9379FGK KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Menstrual Cycle -- blood KW - Ultrasonography KW - Selective Estrogen Receptor Modulators -- administration & dosage KW - Calcium Carbonate -- administration & dosage KW - Drug Therapy, Combination KW - Polyps -- diagnostic imaging KW - Uterine Diseases -- chemically induced KW - Selective Estrogen Receptor Modulators -- adverse effects KW - Risk Factors KW - Selective Estrogen Receptor Modulators -- therapeutic use KW - Adult KW - Dehydroepiandrosterone Sulfate -- blood KW - Middle Aged KW - Uterine Diseases -- diagnostic imaging KW - Female KW - Polyps -- chemically induced KW - Genitalia, Female -- diagnostic imaging KW - Genitalia, Female -- drug effects KW - Carcinoma -- etiology KW - Raloxifene Hydrochloride -- therapeutic use KW - Carcinoma -- prevention & control KW - Breast Neoplasms -- prevention & control KW - Breast Neoplasms -- etiology KW - Raloxifene Hydrochloride -- administration & dosage KW - Raloxifene Hydrochloride -- adverse effects KW - Premenopause -- drug effects KW - Gonadal Steroid Hormones -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69058943?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Salmonella+enterica+Serovar+Typhi+Ty21a+Expressing+Human+Papillomavirus+Type+16+L1+as+a+Potential+Live+Vaccine+against+Cervical+Cancer+and+Typhoid+Fever&rft.au=Fraillery%2C+Dominique%3BBaud%2C+David%3BPang%2C+Susana+Yuk-Ying%3BSchiller%2C+John%3BBobst%2C+Martine%3BZosso%2C+Nathalie%3BPonci%2C+Francoise%3BNardelli-Haefliger%2C+Denise&rft.aulast=Fraillery&rft.aufirst=Dominique&rft.date=2007-10-01&rft.volume=14&rft.issue=10&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2007-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Up-regulation of cyclooxygenase-2 by cobalt chloride-induced hypoxia is mediated by phospholipase D isozymes in human astroglioma cells. AN - 69050327; 17640750 AB - Cyclooxygenase-2 (COX-2) is an isoform of prostaglandin H synthase induced by hypoxia and has been implicated in the growth and progression of a variety of human cancers. In the present study, we investigated the role of phospholipase D (PLD) isozymes in cobalt chloride (CoCl(2))-induced hypoxia-driven COX-2 expression in U87 MG human astroglioma cells. CoCl(2) stimulated PLD activity and synthesis of COX-2 protein in a dose and time-dependent manner. Moreover, elevated expression of PLD1 and PLD2 increased hypoxia-induced COX-2 expression and prostaglandin E2 (PGE(2)) production. Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed CoCl(2)-induced COX-2 expression and PGE(2) formation. In addition, evidence that PLD activity was involved in the stimulation of COX-2 expression was provided by the observations that overexpression of wild type PLD isozymes, but not catalytically inactive PLD isozymes, stimulated CoCl(2)-induced COX-2 expression and PGE(2) production. PLD1 enhanced COX-2 expression by CoCl(2) via reactive oxygen species (ROS), p38 MAPK kinase, PKC-delta, and PKA, but not ERK, whereas PLD2 enhanced CoCl(2)-induced COX-2 expression via ROS and p38 MAPK, but not ERK, PKC-delta, and PKA. Differential regulation of COX-2 expression mediated through PLD isozymes was comparable with that of CoCl(2)-induced PLD activity in these two PLD isozymes. Taken together, our results demonstrate for the first time that PLD1 and PLD2 isozymes enhance CoCl(2)-induced COX-2 expression through differential signaling pathways in astroglioma cells. JF - Biochimica et biophysica acta AU - Ahn, Bong-Hyun AU - Park, Mi Hee AU - Lee, Young Han AU - Kwon, Taeg Kyu AU - Min, Do Sik AD - Cardiovascular Branch National Heart, Lung and Blood Institute (NHLBI), NIH Bldg 10/CRC 5-3288 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1721 EP - 1731 VL - 1773 IS - 12 SN - 0006-3002, 0006-3002 KW - Isoenzymes KW - 0 KW - Lipopolysaccharides KW - Cobalt KW - 3G0H8C9362 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - PTGS2 protein, human KW - Pertussis Toxin KW - EC 2.4.2.31 KW - Phospholipases A2 KW - EC 3.1.1.4 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Phospholipase D KW - EC 3.1.4.4 KW - cobaltous chloride KW - EVS87XF13W KW - Dinoprostone KW - K7Q1JQR04M KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phospholipases A2 -- metabolism KW - Dinoprostone -- biosynthesis KW - Lipopolysaccharides -- pharmacology KW - Humans KW - Signal Transduction -- drug effects KW - Enzyme Activation -- drug effects KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Pertussis Toxin -- pharmacology KW - Cell Hypoxia -- drug effects KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Isoenzymes -- metabolism KW - Type C Phospholipases -- metabolism KW - Phospholipase D -- metabolism KW - Astrocytoma -- enzymology KW - Astrocytoma -- genetics KW - Cyclooxygenase 2 -- genetics KW - Up-Regulation -- drug effects KW - Cyclooxygenase 2 -- metabolism KW - Cobalt -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69050327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Up-regulation+of+cyclooxygenase-2+by+cobalt+chloride-induced+hypoxia+is+mediated+by+phospholipase+D+isozymes+in+human+astroglioma+cells.&rft.au=Ahn%2C+Bong-Hyun%3BPark%2C+Mi+Hee%3BLee%2C+Young+Han%3BKwon%2C+Taeg+Kyu%3BMin%2C+Do+Sik&rft.aulast=Ahn&rft.aufirst=Bong-Hyun&rft.date=2007-12-01&rft.volume=1773&rft.issue=12&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intraperitoneal chemotherapy: implications beyond ovarian cancer. AN - 69042411; 18063547 AB - The National Cancer Institute (NCI) announced in January 2006 the use of intraperitoneal (IP) combined with IV chemotherapy postoperatively as the preferred treatment method for advanced ovarian cancer. The announcement stimulated the need for oncology nurses to become familiar with IP chemotherapy administration and patient management guidelines. IP administration allows a high concentration of chemotherapy to come into direct contact with tumors and surrounding tissues and organs. IP chemotherapy also is administered in clinical trials and some clinical settings for other histologies, such as low-grade gastrointestinal carcinoma and appendiceal carcinoma, which tend to spread locally before invading the bloodstream. Local-regional chemotherapy potentially is an ideal treatment for local spread of those peritoneal carcinomas. Overall side effects from regional treatment are less severe than with systemic treatment. Oncology nurses can help minimize and alleviate discomfort associated with IP chemotherapy administration. This article focuses on nursing management strategies for patients receiving IP chemotherapy for ovarian cancer and other peritoneal carcinomatosis. JF - Clinical journal of oncology nursing AU - Marin, Keith AU - Oleszewski, Karen AU - Muehlbauer, Paula AD - The National Institutes of Health, Bethesda, MD. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 881 EP - 889 VL - 11 IS - 6 SN - 1092-1095, 1092-1095 KW - Nursing KW - United States KW - Drug Monitoring -- methods KW - Information Services KW - Infusions, Intravenous -- nursing KW - Humans KW - Clinical Trials as Topic KW - Patient Care Planning KW - Catheters, Indwelling KW - Patient Education as Topic KW - National Cancer Institute (U.S.) KW - Drug Monitoring -- nursing KW - Practice Guidelines as Topic KW - Female KW - Internet KW - Peritoneal Dialysis -- instrumentation KW - Infusions, Parenteral -- methods KW - Ovarian Neoplasms -- nursing KW - Oncology Nursing -- organization & administration KW - Nurse's Role KW - Infusions, Parenteral -- nursing KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Infusions, Parenteral -- adverse effects KW - Ovarian Neoplasms -- drug therapy KW - Oncology Nursing -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69042411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+journal+of+oncology+nursing&rft.atitle=Intraperitoneal+chemotherapy%3A+implications+beyond+ovarian+cancer.&rft.au=Marin%2C+Keith%3BOleszewski%2C+Karen%3BMuehlbauer%2C+Paula&rft.aulast=Marin&rft.aufirst=Keith&rft.date=2007-12-01&rft.volume=28&rft.issue=10&rft.spage=2244&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2007-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer. AN - 69036141; 17660507 AB - Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)-AKT/protein kinase B-signaling pathway has been associated with multiple human cancers, including thyroid cancer. Recently, we showed that, similar to human thyroid cancer, the PI3K-AKT pathway is overactivated in both the thyroid and metastatic lesions of a mouse model of follicular thyroid carcinoma (TRbeta(PV/PV) mice). This TRbeta(PV/PV) mouse harbors a knockin mutant thyroid hormone receptor beta gene (TRbetaPV mutant) that spontaneously develops thyroid cancer and distant metastasis similar to human follicular thyroid cancer. That the activation of the PI3K-AKT signaling contributes to thyroid carcinogenesis raised the possibility that this pathway could be a potential therapeutic target in follicular thyroid carcinoma. The present study tested this possibility by treating TRbeta(PV/PV) mice with LY294002 (LY), a potent and specific PI3K inhibitor, and evaluating the effect of LY on the spontaneous development of thyroid cancer. LY treatment inhibited the AKT-mammalian target of rapamycin (mTOR)-p70(S6K) signaling, and it decreased cyclin D1 and increased p27(Kip1) expression to inhibit thyroid tumor growth and reduce tumor cell proliferation. LY treatment increased caspase 3 and decreased phosphorylated-BAD to induce apoptosis. In addition, LY treatment reduced the AKT-matrix metalloproteinase 2 signaling to decrease cell motility to block metastatic spread of thyroid tumors. Thus, these altered signaling pathways converged effectively to prolong survival of TRbeta(PV/PV) mice treated with LY. No significant adverse effects were observed for wild-type mice treated similarly with LY. The present study provides the first preclinical evidence for the in vivo efficacy for LY in the treatment of follicular thyroid cancer. JF - Carcinogenesis AU - Furuya, Fumihiko AU - Lu, Changxue AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2451 EP - 2458 VL - 28 IS - 12 KW - Cdkn1b protein, mouse KW - 0 KW - Chromones KW - Morpholines KW - Thyroid Hormone Receptors beta KW - Cyclin D1 KW - 136601-57-5 KW - Cyclin-Dependent Kinase Inhibitor p27 KW - 147604-94-2 KW - 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one KW - 31M2U1DVID KW - Protein Kinases KW - EC 2.7.- KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - MTOR protein, human KW - EC 2.7.1.1 KW - TOR Serine-Threonine Kinases KW - mTOR protein, mouse KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Neoplasm Invasiveness KW - Animals KW - Apoptosis KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- drug therapy KW - Mice KW - Cyclin-Dependent Kinase Inhibitor p27 -- metabolism KW - Matrix Metalloproteinase 2 -- metabolism KW - Protein Kinases -- metabolism KW - Mice, Mutant Strains KW - Cyclin D1 -- metabolism KW - Tumor Cells, Cultured KW - Cell Movement -- drug effects KW - Signal Transduction KW - Caspase 3 -- metabolism KW - Adenocarcinoma, Follicular -- secondary KW - Thyroid Neoplasms -- metabolism KW - Morpholines -- pharmacology KW - Adenocarcinoma, Follicular -- drug therapy KW - Thyroid Hormone Receptors beta -- metabolism KW - Chromones -- pharmacology KW - Adenocarcinoma, Follicular -- metabolism KW - Morpholines -- therapeutic use KW - Thyroid Neoplasms -- drug therapy KW - Thyroid Neoplasms -- pathology KW - Thyroid Hormone Receptors beta -- genetics KW - Chromones -- therapeutic use KW - Phosphatidylinositol 3-Kinases -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69036141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+phosphatidylinositol+3-kinase+delays+tumor+progression+and+blocks+metastatic+spread+in+a+mouse+model+of+thyroid+cancer.&rft.au=Furuya%2C+Fumihiko%3BLu%2C+Changxue%3BWillingham%2C+Mark+C%3BCheng%2C+Sheue-Yann&rft.aulast=Furuya&rft.aufirst=Fumihiko&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2451&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. AN - 69033512; 17768178 AB - Data from epidemiologic and twin studies suggest an important role of genetic susceptibility in prostate cancer. Variants of the macrophage scavenger receptor 1 (MSR1) gene have been linked to both hereditary and sporadic prostate cancer, although the evidence is inconclusive. Most studies have been conducted on Caucasians. The role of MSR1 in prostate cancer development among Asians, for whom rates of prostate cancer are low but rising rapidly, is unclear. To evaluate further the relationship between MSR1 variants and prostate cancer risk, we sequenced all the 11 MSR1 exons, exon-intron junctions, promoter regions, as well as 5' and 3' untranslated regions (UTRs) in 86 individuals from Shanghai, China. We identified a total of 21 sequence variants, including three novel variants that have not been reported previously. To balance genotyping cost and the capacity to capture sufficient genetic variation, we genotyped four haplotype-tagging variants (P275A, INDEL7, P346P and 3' UTR 70006), which capture 85% of the genetic variation in MSR1 in this population. These four variants, plus two other variants (PRO3 and INDEL1) that have been linked to prostate cancer risk in the previous studies, were typed for all study subjects, which included 130 prostate cancer cases, 130 patients with benign prostatic hyperplasia and 150 controls randomly selected from the population. Three of the six variants were associated with prostate cancer. Men with a P346P (a novel variant) G allele (AG + GG) had a significantly reduced risk of total prostate cancer [odds ratio = 0.47, 95% confidence interval (CI) 0.23-0.96], whereas those with a P275A G allele had a 37% reduced risk of prostate cancer (95% CI 0.39-1.02), with more pronounced reduction in risk seen for localized cancer cases (odds ratio = 0.25, 95% CI 0.12-0.52; P = 0.001). In addition, men with the INDEL7 variant had a 67% reduced risk of localized cancer (95% CI 0.16-0.68). Based on the four tagging variants, we inferred four major haplotypes that accounted for >90% of the haplotype variation in this population. The haplotype frequencies were significantly different between localized prostate cancer cases and controls, with a global P value of 0.004, and the haplotype containing the minor alleles of the P275A and INDEL7 variants was associated with a significantly reduced risk of localized prostate cancer (odds ratio = 0.28, 95% CI 0.13-0.59), relative to the most common haplotype. These results, although modest and confined mainly to localized prostate cancer, suggest that MSR1 polymorphisms may play a role in prostate cancer etiology in Chinese men. The role of MSR1 warrants further investigation in larger studies and other populations. JF - Carcinogenesis AU - Hsing, Ann W AU - Sakoda, Lori C AU - Chen, Jinbo AU - Chokkalingam, Anand P AU - Sesterhenn, Isabel AU - Gao, Yu-Tang AU - Xu, Jianfeng AU - Zheng, S Lilly AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. hsinga@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2530 EP - 2536 VL - 28 IS - 12 KW - 3' Untranslated Regions KW - 0 KW - 5' Untranslated Regions KW - MSR1 protein, human KW - Scavenger Receptors, Class A KW - Index Medicus KW - Promoter Regions, Genetic KW - Exons KW - Humans KW - Introns KW - Case-Control Studies KW - Aged KW - Male KW - China KW - Asian Continental Ancestry Group KW - Scavenger Receptors, Class A -- genetics KW - Scavenger Receptors, Class A -- physiology KW - Polymorphism, Genetic KW - Prostatic Neoplasms -- ethnology KW - Prostatic Neoplasms -- genetics KW - Prostatic Hyperplasia -- genetics KW - Genetic Predisposition to Disease KW - Prostatic Hyperplasia -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=MSR1+variants+and+the+risks+of+prostate+cancer+and+benign+prostatic+hyperplasia%3A+a+population-based+study+in+China.&rft.au=Hsing%2C+Ann+W%3BSakoda%2C+Lori+C%3BChen%2C+Jinbo%3BChokkalingam%2C+Anand+P%3BSesterhenn%2C+Isabel%3BGao%2C+Yu-Tang%3BXu%2C+Jianfeng%3BZheng%2C+S+Lilly&rft.aulast=Hsing&rft.aufirst=Ann&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2530&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ovarian volumes among women with endometrial carcinoma: associations with risk factors and serum hormones. AN - 69033073; 17720234 AB - Data suggest that post-menopausal women with larger ovaries are at increased risk for endometrial carcinoma; however, analyses comparing ovarian volume to serum hormone levels are limited. Accordingly, we assessed ovarian volumes in relation to serum sex hormone levels among post-menopausal women with endometrial carcinoma who participated in a multi-center case-control study. Data for established risk and protective factors for endometrial carcinoma were collected via in-person interviews. Ovarian volumes were estimated from pathology reports. Associations between exposures and age-adjusted ovarian volumes were analyzed for 175 cases with available data. For a subset of 135 cases, we analyzed relationships between ovarian volume, adjusted for age and body mass index (BMI), and serum hormone levels by analysis of variance. Ovarian volume declined progressively from 1.83 cm3 among women ages 55-59 years to 1.23 cm3 among women age 70 years or older (p-trend=0.02). Larger ovarian volume was associated with early menarche (p-trend=0.03), having given birth (p=0.01), and weakly with elevated BMI (p-trend=0.06). After adjustment, increased ovarian volume was associated with higher estradiol (p-trend=0.007); albumin-bound estradiol (p-trend=0.01); and free estradiol (p-trend=0.006) levels; androstenedione, estrone and estrone sulfate showed similar, though non-significant associations. Among women with endometrial carcinoma, larger ovaries were associated with higher serum levels of estrogens. Further studies examining the role of the ovaries in post-menopausal hormonal carcinogenesis are warranted. JF - Gynecologic oncology AU - Sherman, Mark E AU - Madigan, M Patricia AU - Lacey, James V AU - Garcia-Closas, Montserrat AU - Potischman, Nancy AU - Carreon, Joseph D AU - Hartge, Patricia AU - Brinton, Louise A AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Hormonal and Reproductive Epidemiology Branch, 6120 Executive Boulevard, Rockville, MD 20852-7234, USA. shermanm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 431 EP - 435 VL - 107 IS - 3 KW - Gonadal Steroid Hormones KW - 0 KW - Sex Hormone-Binding Globulin KW - Estrone KW - 2DI9HA706A KW - Androstenedione KW - 409J2J96VR KW - Estradiol KW - 4TI98Z838E KW - estrone sulfate KW - QTL48N278K KW - Index Medicus KW - Estradiol -- blood KW - Postmenopause KW - Estrone -- analogs & derivatives KW - Humans KW - Case-Control Studies KW - Sex Hormone-Binding Globulin -- metabolism KW - Aged KW - Middle Aged KW - Estrone -- blood KW - Female KW - Androstenedione -- blood KW - Ovary -- pathology KW - Endometrial Neoplasms -- pathology KW - Endometrial Neoplasms -- blood KW - Gonadal Steroid Hormones -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69033073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gynecologic+oncology&rft.atitle=Ovarian+volumes+among+women+with+endometrial+carcinoma%3A+associations+with+risk+factors+and+serum+hormones.&rft.au=Sherman%2C+Mark+E%3BMadigan%2C+M+Patricia%3BLacey%2C+James+V%3BGarcia-Closas%2C+Montserrat%3BPotischman%2C+Nancy%3BCarreon%2C+Joseph+D%3BHartge%2C+Patricia%3BBrinton%2C+Louise+A&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2007-12-01&rft.volume=107&rft.issue=3&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Gynecologic+oncology&rft.issn=1095-6859&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Clin Endocrinol Metab. 2005 Jul;90(7):3847-53 [15827095] Obstet Gynecol. 2005 Aug;106(2):219-26 [16055568] J Womens Health (Larchmt). 2005 Oct;14(8):704-12 [16232102] Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1550-4 [16896048] Menopause. 2000 Jan-Feb;7(1):53-61 [10646704] J Clin Endocrinol Metab. 2000 Feb;85(2):645-51 [10690870] Gynecol Oncol. 2000 Jun;77(3):410-2 [10831351] Eur J Endocrinol. 2001 Jul;145(1):1-9 [11415846] Obstet Gynecol. 1965 Jun;25:747-64 [14287465] Obstet Gynecol. 1963 Feb;21:175-86 [13932912] Menopause. 1998 Winter;5(4):207-10 [9872485] Maturitas. 2002 Oct 25;43(2):77-85 [12385855] Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43 [12496040] Endocr Rev. 2003 Apr;24(2):152-82 [12700178] Eur J Endocrinol. 2004 Feb;150(2):161-71 [14763914] Oncogene. 2004 Aug 23;23(38):6365-78 [15322511] Endocrinol Metab Clin North Am. 2004 Dec;33(4):661-74 [15501639] Maturitas. 1986 Mar;8(1):57-65 [3702762] Am J Obstet Gynecol. 1992 Nov;167(5):1317-25 [1442985] J Natl Cancer Inst. 1996 Aug 21;88(16):1127-35 [8757192] Ann Intern Med. 1997 Jan 1;126(1):32-5 [8992921] Mod Pathol. 1997 Oct;10(10):963-8 [9346174] Cancer Causes Control. 1998 Mar;9(2):199-207 [9578297] Hum Reprod. 1998 Jun;13(6):1437-41 [9688367] Maturitas. 1998 Jun 17;29(3):239-45 [9699195] J Reprod Med. 1998 Aug;43(8 Suppl):725-33 [9750201] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency. AN - 69030277; 17690114 AB - Oncogenic K-ras is one of the most common genetic alterations in human lung adenocarcinomas. In addition, inactivation of clusters of tumor suppressor genes is required to bring about classical characteristics of cancer including angiogenesis as a prelude to invasion and metastasis. Transforming growth factor-beta (TGF-beta) 1 is a tumor suppressor gene that is implicated in lung cancer progression. Although in vitro studies have shown that TGF-beta1 and Ras pathways cooperate during tumorigenesis, the biology of interaction of TGF-beta1 and Ras has not been studied in in vivo tumorigenesis. We hypothesized that inactivation of TGF-beta1 in addition to oncogeneic activation of K-ras would lead to early initiation and faster progression to lung adenocarcinoma and invasion and metastasis. Heterozygous (HT) TGF-beta1 mice were mated with latent activatable (LA) mutated K-ras mice to generate TGF-beta1(+/+), K-ras LA (wild-type (WT)/LA) and TGF-beta1(+/-), K-ras LA (HT/LA) mice. Both HT/LA and WT/LA mice developed spontaneous lung tumors, but HT/LA mice progressed to adenocarcinomas significantly earlier compared with WT/LA mice. In addition, WT/LA adenocarcinomas had significantly higher angiogenic activity compared with HT/LA adenocarcinomas. Thus, while oncogenic K-ras mutation and insensitivity to the growth regulatory effects of TGF-beta1 is essential for initiation and progression of mouse lung tumors to adenocarcinoma, a full gene dosage of TGF-beta1 is required for tumor-induced angiogenesis and invasive potential. This study identifies a number of genes not previously associated with lung cancer that are involved in tumor induction and progression. In addition, we provide evidence that progression to invasive angiogenic lesions requires TGF-beta1 responsiveness in addition to Ras mutation. JF - Carcinogenesis AU - Pandey, Jyotsna AU - Umphress, Sarah M AU - Kang, Yang AU - Angdisen, Jerry AU - Naumova, Alena AU - Mercer, Kim L AU - Jacks, Tyler AU - Jakowlew, Sonia B AD - Cell and Cancer Biology Branch, National Cancer Institute, 9610 Medical Center Drive, Suite 300, Rockville, MD 20850, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2589 EP - 2596 VL - 28 IS - 12 KW - Transforming Growth Factor beta1 KW - 0 KW - Index Medicus KW - Animals KW - Mice, Mutant Strains KW - Oligonucleotide Array Sequence Analysis KW - Heterozygote KW - Mice, Inbred C57BL KW - Disease Progression KW - Mice KW - Neovascularization, Pathologic KW - Mutation KW - Adenocarcinoma -- metabolism KW - Lung Neoplasms -- blood supply KW - Genes, ras -- physiology KW - Adenocarcinoma -- blood supply KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Transforming Growth Factor beta1 -- physiology KW - Transforming Growth Factor beta1 -- genetics KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69030277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Modulation+of+tumor+induction+and+progression+of+oncogenic+K-ras-positive+tumors+in+the+presence+of+TGF-+b1+haploinsufficiency.&rft.au=Pandey%2C+Jyotsna%3BUmphress%2C+Sarah+M%3BKang%2C+Yang%3BAngdisen%2C+Jerry%3BNaumova%2C+Alena%3BMercer%2C+Kim+L%3BJacks%2C+Tyler%3BJakowlew%2C+Sonia+B&rft.aulast=Pandey&rft.aufirst=Jyotsna&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2589&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-04 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. AN - 69029469; 18006619 AB - (11)C-PBR28 ([methyl-(11)C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine) is a recently developed radioligand to image peripheral benzodiazepine receptors (PBRs) in brain. The aim of this study was to estimate the human radiation doses of (11)C-PBR28 based on biodistribution data in monkeys and humans. In addition, we scanned 1 human subject who fortuitously behaved as if he lacked the PBR binding protein. Whole-body PBR images were acquired after intravenous bolus administration of (11)C-PBR28 in 7 healthy humans (651 +/- 111 MBq) and 2 rhesus monkeys (370 +/- 59.9 MBq). One monkey was scanned after receptor blockade with PK 11195 (10.7 mg/kg intravenously). For typical subjects (subjects 1-6), the 3 organs with highest exposure were those with the high PBR densities (kidneys, spleen, and lungs), and the effective dose was 6.6 microSv/MBq. The unusual subject (subject 7) had 60%-90% less uptake in these 3 organs, resulting in 28% lower effective dose. The activity in the baseline monkey scans was greater than that in humans for organs with high PBR densities. For this reason, the human effective dose was overestimated by 60% with monkey biodistribution data. The monkey with receptor blockade had an overall distribution qualitatively similar to that of the unusual human subject (subject 7), with decreased exposure to lungs, kidney, and spleen. The effective dose of (11)C-PBR28 was modest and was similar to that of several other (11)C-radioligands. Lack of receptor binding in the unusual human subject and in the monkey with receptor blockade decreased exposure to organs with high PBR densities and enhanced uptake in excretory and metabolic pathways. JF - Journal of nuclear medicine : official publication, Society of Nuclear Medicine AU - Brown, Amira K AU - Fujita, Masahiro AU - Fujimura, Yota AU - Liow, Jeih-San AU - Stabin, Michael AU - Ryu, Yong H AU - Imaizumi, Masao AU - Hong, Jinsoo AU - Pike, Victor W AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland 20892-2035, USA. amirabrown@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2072 EP - 2079 VL - 48 IS - 12 SN - 0161-5505, 0161-5505 KW - (methyl-(11)C)N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine KW - 0 KW - Carbon Radioisotopes KW - Isoquinolines KW - Pyrimidines KW - Radiopharmaceuticals KW - Receptors, GABA KW - TSPO protein, human KW - PK 11195 KW - YNF83VN1RL KW - Index Medicus KW - Animals KW - Isoquinolines -- pharmacokinetics KW - Humans KW - Adult KW - Macaca mulatta KW - Tissue Distribution KW - Radioligand Assay KW - Species Specificity KW - Male KW - Female KW - Receptors, GABA -- analysis KW - Radiopharmaceuticals -- pharmacokinetics KW - Radiation Dosage KW - Positron-Emission Tomography -- methods KW - Pyrimidines -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69029469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Prospective+investigation+of+the+cigarette+smoking-head+and+neck+cancer+association+by+sex&rft.au=Freedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BLeitzmann%2C+Michael+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-10-01&rft.volume=110&rft.issue=7&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.22930 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-15 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease. AN - 69028118; 18046720 AB - More than 70% of alcohol is consumed by 10% of the population in the United States. Implicit in this statistic is that tremendous variation in the pattern of drinking (quantity, frequency, and duration) exists among alcohol consumers. Individuals who are binge or chronic drinkers will have different health outcomes than social drinkers. Therefore, knowing the pattern of drinking will shed light on how severely individuals are alcohol-dependent and on the extent of liver damage. Thus, these parameters assume particular relevance for the treatment-providing physician. Genetic factors contribute substantially to differences in alcohol metabolism. Variations in the activities of the alcohol-metabolizing enzymes, cytosolic alcohol dehydrogenase and mitochondrial aldehyde dehydrogenase, in part determine blood alcohol concentration, thereby contributing to the predisposition to becoming alcohol-dependent and to susceptibility to alcohol-induced liver damage. Chronic alcohol consumption induces cytochrome P450 2E1, a microsomal enzyme that metabolizes alcohol at high concentrations and also metabolizes medications such as acetaminophen and protease inhibitors. Alcohol metabolism changes the redox state of the liver, which leads to alterations in hepatic lipid, carbohydrate, protein, lactate, and uric acid metabolism. The quantity and frequency of alcohol consumption severely impact the liver in the presence of comorbid conditions such as infection with hepatitis B or C and/or human immunodeficiency virus, type 2 diabetes, hemochromatosis, or obesity and thus have implications with respect to the extent of injury and response to medications. Knowledge of the relationships between the quantity, frequency, and patterns of drinking and alcoholic liver disease is limited. A better understanding of these relationships will guide hepatologists in managing alcoholic liver disease. JF - Hepatology (Baltimore, Md.) AU - Zakhari, Samir AU - Li, Ting-Kai AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. szakhari@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2032 EP - 2039 VL - 46 IS - 6 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Ethanol -- adverse effects KW - Alcohol Drinking -- adverse effects KW - Alcoholism -- complications KW - Liver Diseases, Alcoholic -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69028118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Determinants+of+alcohol+use+and+abuse%3A+Impact+of+quantity+and+frequency+patterns+on+liver+disease.&rft.au=Zakhari%2C+Samir%3BLi%2C+Ting-Kai&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2007-12-01&rft.volume=46&rft.issue=6&rft.spage=2032&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=1527-3350&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulatory factor X4 variant 3: a transcription factor involved in brain development and disease. AN - 69026224; 17510980 AB - Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas interruption of two alleles (homozygous, -/-) caused fatal failure of dorsal midline brain structure formation. These mutagenesis studies implicated RFX4_v3 in early brain development as well as the genesis of the SCO. Rfx4_v3 deficiency presumably causes abnormalities in brain by altering the expression levels of many genes that are crucial for brain morphogenesis, such as the signaling components in the Wnt, bone morphogenetic protein, and retinoic acid pathways. RFX4_v3 might affect these critical signaling pathways in brain development. Cx3cl1, a chemokine gene highly expressed in brain, was identified as a direct target for RFX4_v3, indicating that RFX4_v3 possesses trans-acting activity to stimulate gene expression. Rfx4_v3 is highly expressed in the suprachiasmatic nucleus and might be involved in regulating the circadian clock. One haplotype in RFX4_v3 gene is linked to a higher risk of bipolar disorder, suggesting that this protein might contribute to the pathogenesis of the disease. This Mini-Review describes our current knowledge about RFX4_v3, an important protein that appears to be involved in many aspects of brain development and disease. (c) 2007 Wiley-Liss, Inc. JF - Journal of neuroscience research AU - Zhang, Donghui AU - Zeldin, Darryl C AU - Blackshear, Perry J AD - Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 3515 EP - 3522 VL - 85 IS - 16 SN - 0360-4012, 0360-4012 KW - DNA-Binding Proteins KW - 0 KW - Regulatory Factor X Transcription Factors KW - Rfx4 protein, mouse KW - Transcription Factors KW - Index Medicus KW - Animals KW - Hydrocephalus -- physiopathology KW - Bipolar Disorder -- physiopathology KW - Humans KW - Hydrocephalus -- metabolism KW - Signal Transduction -- genetics KW - Bipolar Disorder -- genetics KW - Bipolar Disorder -- metabolism KW - Circadian Rhythm -- genetics KW - Hydrocephalus -- genetics KW - Nervous System Malformations -- metabolism KW - Transcription Factors -- metabolism KW - Brain Diseases -- genetics KW - DNA-Binding Proteins -- genetics KW - Brain -- metabolism KW - Brain Diseases -- physiopathology KW - Transcription Factors -- genetics KW - Brain Diseases -- metabolism KW - Gene Expression Regulation, Developmental -- genetics KW - Nervous System Malformations -- genetics KW - Nervous System Malformations -- physiopathology KW - Brain -- embryology KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69026224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroscience+research&rft.atitle=Regulatory+factor+X4+variant+3%3A+a+transcription+factor+involved+in+brain+development+and+disease.&rft.au=Zhang%2C+Donghui%3BZeldin%2C+Darryl+C%3BBlackshear%2C+Perry+J&rft.aulast=Zhang&rft.aufirst=Donghui&rft.date=2007-12-01&rft.volume=85&rft.issue=16&rft.spage=3515&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroscience+research&rft.issn=03604012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-19 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2002 Sep 12;35(6):1029-41 [12354394] Development. 2002 Dec;129(23):5487-98 [12403718] Development. 2003 May;130(10):2039-50 [12668619] Psychiatr Genet. 2003 Jun;13(2):77-84 [12782963] J Neurosci Res. 2003 Jul 1;73(1):81-8 [12815711] Development. 2003 Oct;130(19):4539-52 [12925582] J Biol Chem. 2004 Mar 12;279(11):10237-42 [14701801] Mol Cell Biol. 2004 May;24(10):4417-27 [15121860] PLoS Biol. 2004 Aug;2(8):E219 [15314648] Circ Res. 2004 Sep 3;95(5):506-14 [15256482] J Pathol. 2004 Nov;204(4):470-7 [15495266] Fed Proc. 1983 Aug;42(11):2809-14 [6873309] Mol Endocrinol. 1992 May;6(5):773-85 [1603086] Development. 1997 Jun;124(11):2203-12 [9187146] Mol Cell Biol. 1999 Jun;19(6):3940-50 [10330134] Mol Psychiatry. 2005 Oct;10(10):920-7 [15940297] Cancer Sci. 2005 Nov;96(11):801-9 [16271074] J Clin Invest. 2006 Jul;116(7):1828-32 [16823482] J Neurochem. 2006 Aug;98(3):860-75 [16893423] Eur J Neurosci. 2006 Aug;24(4):1020-30 [16930429] Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R271-7 [16987893] J Mol Biol. 1999 Nov 19;294(1):121-37 [10556033] Development. 2000 Feb;127(3):457-67 [10631167] Nature. 2000 Feb 24;403(6772):916-21 [10706293] Mol Cell. 2000 Mar;5(3):411-21 [10882127] Microsc Res Tech. 2001 Mar 1;52(5):573-90 [11241867] Annu Rev Immunol. 2001;19:331-73 [11244040] Hum Mutat. 2001;18(1):1-12 [11438988] J Biol Chem. 2002 Jan 4;277(1):836-42 [11682486] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Simultaneous determination of salsolinol enantiomers and dopamine in human plasma and cerebrospinal fluid by chemical derivatization coupled to chiral liquid chromatography/electrospray ionization-tandem mass spectrometry. AN - 68562470; 17973500 AB - A sensitive, specific, and robust method to simultaneously determine enantiomeric salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, SAL), a potential biomarker implicated in alcohol-related neurotoxicity in a stereoselective manner, and its precursor dopamine (DA) has been developed using simple chemical derivatization and chiral separation coupled with electrospray ionization-tandem mass spectrometry (ESI-MS/MS). SAL enantiomers and DA were converted to stable pentafluorobenzyl (PFB) derivatives directly from aqueous media. Bulky PFB groups introduced into the SAL structure enabled baseline separation of SAL stereoisomers on a chiral column without cumbersome chiral derivatization to unstable SAL diastereomers. Subsequent analysis by ESI-MS/MS with multiple reaction monitoring (MRM) in the presence of deuterium-labeled internal standards allowed specific detection of both derivatives with a wide dynamic range (SAL, 0.5-5000 pg; DA, 0.02-20 ng). The limit of quantitation assayed in the plasma matrix was below 10 pg for each SAL enantiomer and 100 pg for DA. Both coefficient of variance and error for inter- and intraday measurements in the blank plasma were less than 10% for SAL and DA in the concentration range of 10-4000 pg/mL and 0.1-8 ng/mL, respectively. This strategy enabled routine and specific determination of both SAL enantiomers and DA from 0.5 mL of human plasma and cerebrospinal fluid, which has not been possible using existing methodologies. JF - Analytical chemistry AU - Lee, Jeongrim AU - Huang, Bill X AU - Yuan, Zhixin AU - Kim, Hee-Yong AD - Laboratory of Molecular Signaling, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, Bethesda, Maryland 20892-9410, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 9166 EP - 9173 VL - 79 IS - 23 SN - 0003-2700, 0003-2700 KW - Isoquinolines KW - 0 KW - salsolinol KW - 9ILS801M65 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Sensitivity and Specificity KW - Stereoisomerism KW - Humans KW - Isoquinolines -- blood KW - Isoquinolines -- cerebrospinal fluid KW - Tandem Mass Spectrometry -- methods KW - Dopamine -- analysis KW - Dopamine -- blood KW - Isoquinolines -- analysis KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Dopamine -- cerebrospinal fluid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68562470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Simultaneous+determination+of+salsolinol+enantiomers+and+dopamine+in+human+plasma+and+cerebrospinal+fluid+by+chemical+derivatization+coupled+to+chiral+liquid+chromatography%2Felectrospray+ionization-tandem+mass+spectrometry.&rft.au=Iyer%2C+Lakshminarayan+M%3BAnantharaman%2C+Vivek%3BAravind%2C+L&rft.aulast=Iyer&rft.aufirst=Lakshminarayan&rft.date=2007-10-01&rft.volume=23&rft.issue=20&rft.spage=2660&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-28 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - RNA polymerase is poised for activation across the genome. AN - 68559308; 17994021 AB - Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA polymerase II (Pol II) to a promoter is necessary and sufficient for activation of genes. However, there are a few notable exceptions to this paradigm, including heat shock genes and several proto-oncogenes, whose expression is attenuated by regulated stalling of polymerase elongation within the promoter-proximal region. To determine the importance of polymerase stalling for transcription regulation, we carried out a genome-wide search for Drosophila melanogaster genes with Pol II stalled within the promoter-proximal region. Our data show that stalling is widespread, occurring at hundreds of genes that respond to stimuli and developmental signals. This finding indicates a role for regulation of polymerase elongation in the transcriptional responses to dynamic environmental and developmental cues. JF - Nature genetics AU - Muse, Ginger W AU - Gilchrist, Daniel A AU - Nechaev, Sergei AU - Shah, Ruchir AU - Parker, Joel S AU - Grissom, Sherry F AU - Zeitlinger, Julia AU - Adelman, Karen AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1507 EP - 1511 VL - 39 IS - 12 KW - RNA Polymerase II KW - EC 2.7.7.- KW - Index Medicus KW - Animals KW - Drosophila melanogaster KW - Chromatin Immunoprecipitation KW - Transcriptional Activation KW - RNA Polymerase II -- metabolism KW - Genome, Insect KW - Transcription, Genetic KW - Gene Expression Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68559308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Inhibition+of+lipid+peroxidation+and+enhancement+of+GST+activity+by+cardamom+and+cinnamon+during+chemically+induced+colon+carcinogenesis+in+Swiss+albino+mice.&rft.au=Bhattacharjee%2C+Shamee%3BRana%2C+Tapasi%3BSengupta%2C+Archana&rft.aulast=Bhattacharjee&rft.aufirst=Shamee&rft.date=2007-10-01&rft.volume=8&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-11 N1 - Date created - 2007-11-29 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE6714; GEO N1 - SuppNotes - Cited By: Cell. 1988 Sep 9;54(6):795-804 [3136931] Mol Cell Biol. 1986 Nov;6(11):3984-9 [3099167] Genes Dev. 1992 Nov;6(11):2201-13 [1427080] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7923-7 [8367444] Genes Dev. 1995 Mar 1;9(5):559-72 [7698646] J Mol Biol. 1995 Oct 6;252(5):522-35 [7563071] Nucleic Acids Res. 1998 Feb 15;26(4):919-24 [9461448] J Virol. 1998 Sep;72(9):7154-9 [9696809] Cold Spring Harb Symp Quant Biol. 1998;63:289-300 [10384293] Cold Spring Harb Symp Quant Biol. 1998;63:347-56 [10384299] J Immunol. 1999 Oct 15;163(8):4375-82 [10510378] Mol Cell. 2005 Jan 7;17(1):103-12 [15629721] FEBS Lett. 2005 Feb 7;579(4):909-15 [15680973] Nature. 2005 Aug 11;436(7052):876-80 [15988478] Cell. 2005 Aug 26;122(4):517-27 [16122420] Cell. 2006 Apr 21;125(2):301-13 [16630818] Mol Cell Biol. 2006 Aug;26(16):6094-104 [16880520] Nat Biotechnol. 2006 Aug;24(8):963-70 [16900145] Nat Rev Mol Cell Biol. 2006 Aug;7(8):557-67 [16936696] Genes Dev. 2007 May 1;21(9):1031-6 [17473169] EMBO J. 1992 Sep;11(9):3307-14 [1505520] Mol Cell Biol. 1990 Nov;10(11):6041-5 [2172790] Mol Cell Biol. 2002 May;22(9):2918-27 [11940650] Curr Biol. 2003 Feb 18;13(4):350-7 [12593803] Mol Cell Biol. 2003 Mar;23(6):1863-73 [12612062] Genes Dev. 2003 Jun 1;17(11):1402-14 [12782658] Annu Rev Biochem. 2003;72:693-715 [12676794] Mol Cell Biol. 2003 Nov;23(21):7628-37 [14560008] Genes Dev. 2004 Sep 1;18(17):2134-46 [15342491] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] Comment In: Nat Genet. 2007 Dec;39(12):1421-2 [18046324] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleotide sequence variation within the human tyrosine kinase B neurotrophin receptor gene: association with antisocial alcohol dependence. AN - 68549019; 17200667 AB - To identify sequence variants in genes that may have roles in neuronal responses to alcohol, we resequenced the 5' region of tyrosine kinase B neurotrophin receptor gene (NTRK2) and determined linkage disequilibrium (LD) values, haplotype structure, and performed association analyses using 43 single nucleotide polymorphisms (SNPs) covering the entire NTRK2 region in a Finnish Caucasian sample of 229 alcohol-dependent subjects with antisocial personality disorder (ASPD) and 287 healthy controls. Individually, three SNPs were associated with alcohol dependence and alcohol abuse (AD) (P-value from 0.0019 to 0.0059, significance level was set at P100-fold. Humanized immunoglobulin G (IgG) 5H2, originally produced from an expression vector, has been shown to be a variant containing a nine-amino-acid deletion in the Fc region which completely ablates antibody-dependent enhancement of DENV replication in vitro. The variant MAb, termed IgG 5H2 deltaD, is particularly attractive for exploring its protective capacity in vivo. Passive transfer of IgG 5H2 deltaD at 20 microg/mouse afforded 50% protection of suckling mice against challenge with 25 50% lethal doses of mouse neurovirulent DENV-4 strain H241. Passive transfer of antibody to monkeys was conducted to demonstrate proof of concept for protection against DENV challenge. Monkeys that received 2 mg/kg of body weight of IgG 5H2 deltaD were completely protected against 100 50% monkey infectious doses (MID50) of DENV-4, as indicated by the absence of viremia and seroconversion. A DENV-4 escape mutant that contained a Lys174-Glu substitution identical to that found in vitro was isolated from monkeys challenged with 10(6) MID50 of DENV-4. This substitution was also present in all naturally occurring isolates belonging to DENV-4 genotype III. These studies have important implications for possible antibody-mediated prevention of DENV infection. JF - Journal of virology AU - Lai, Ching-Juh AU - Goncalvez, Ana P AU - Men, Ruhe AU - Wernly, Claire AU - Donau, Olivia AU - Engle, Ronald E AU - Purcell, Robert H AD - Laboratory of Infectious Diseases, National Institutes of Health, 50 South Drive MSC 8005, Bethesda, MD 20892, USA. clai@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 12766 EP - 12774 VL - 81 IS - 23 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Viral KW - Antigens, Viral KW - Epitopes KW - Index Medicus KW - Animals KW - Amino Acid Substitution -- genetics KW - DNA Mutational Analysis KW - Neutralization Tests KW - Lethal Dose 50 KW - Mice KW - Macaca mulatta KW - Mice, Inbred BALB C KW - Immunization, Passive -- methods KW - Epitope Mapping KW - Survival Analysis KW - Antibodies, Viral -- therapeutic use KW - Antibodies, Viral -- genetics KW - Antibodies, Monoclonal -- genetics KW - Antigens, Viral -- immunology KW - Dengue Virus -- immunology KW - Epitopes -- immunology KW - Antibodies, Viral -- immunology KW - Dengue -- prevention & control KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68494649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2007-10-01&rft.volume=197&rft.issue=4&rft.spage=356.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-18 N1 - Date created - 2007-11-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Virol. 1991 Jun;72 ( Pt 6):1323-9 [1710648] Am J Trop Med Hyg. 1990 Aug;43(2):212-8 [1975159] J Virol. 1993 Nov;67(11):6567-75 [8411360] Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2395-400 [8146129] Nature. 1995 May 25;375(6529):291-8 [7753193] J Gen Virol. 1997 Jan;78 ( Pt 1):31-7 [9010282] J Gen Virol. 1997 Sep;78 ( Pt 9):2279-84 [9292015] Electrophoresis. 1997 Dec;18(15):2714-23 [9504803] Virology. 1998 Jul 5;246(2):317-28 [9657950] Am J Trop Med Hyg. 1952 Jan;1(1):30-50 [14903434] Am J Trop Med Hyg. 1952 Jan;1(1):66-77 [14903437] Am J Trop Med Hyg. 1958 Sep;7(5):561-73 [13571577] J Virol. 2004 Dec;78(23):12910-8 [15542643] J Virol. 2004 Dec;78(23):12919-28 [15542644] J Virol. 2005 Jan;79(2):1223-31 [15613349] J Infect Dis. 2005 Mar 1;191(5):710-8 [15688284] Nature. 2005 Sep 29;437(7059):764-9 [16193056] J Virol. 2006 Jul;80(14):6982-92 [16809304] J Virol. 2006 Oct;80(19):9557-68 [16973559] Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7 [17517625] J Virol. 2007 Nov;81(21):11828-39 [17715236] Cell Host Microbe. 2007 Apr 19;1(2):135-45 [18005691] J Virol. 2001 Aug;75(16):7769-73 [11462053] J Clin Microbiol. 2001 Dec;39(12):4506-13 [11724870] Arch Virol. 2001 Dec;146(12):2469-79 [11811694] Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91 [12759475] Mol Biol Evol. 2003 Oct;20(10):1650-8 [12832629] J Virol. 2004 Jan;78(1):378-88 [14671119] Adv Virus Res. 2003;59:315-41 [14696333] Nature. 2004 Jan 22;427(6972):313-9 [14737159] Am J Trop Med Hyg. 2003 Dec;69(6 Suppl):5-11 [14740949] EMBO J. 2004 Feb 25;23(4):728-38 [14963486] J Virol. 2004 May;78(9):4665-74 [15078949] J Comput Chem. 2004 Oct;25(13):1605-12 [15264254] Vaccine. 2004 Sep 9;22(27-28):3722-6 [15315852] Virology. 2004 Nov 10;329(1):168-79 [15476884] Yale J Biol Med. 1970 Apr;42(5):350-62 [5419208] Am J Trop Med Hyg. 1976 Jan;25(1):146-50 [3980] Nature. 1977 Feb 24;265(5596):739-41 [404559] J Infect Dis. 1979 Oct;140(4):527-33 [117061] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Am J Epidemiol. 1984 Nov;120(5):653-69 [6496446] Trans R Soc Trop Med Hyg. 1985;79(2):248-51 [2860743] Arch Virol. 1985;86(1-2):129-35 [4038069] J Gen Virol. 1986 Feb;67 ( Pt 2):229-34 [3944585] Am J Trop Med Hyg. 1986 Mar;35(2):393-400 [3513650] Adv Virus Res. 1986;31:103-68 [2428213] J Virol. 1986 Dec;60(3):1153-5 [3783816] Am J Trop Med Hyg. 1987 Mar;36(2):427-34 [3826503] Bull Pan Am Health Organ. 1987;21(3):270-9 [3442718] J Immunol. 1988 Nov 15;141(10):3606-10 [2460542] J Virol. 1989 Feb;63(2):564-71 [2463377] Virology. 1989 Mar;169(1):90-9 [2466373] J Immunol. 1990 Apr 15;144(8):3183-6 [2139079] Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5139-43 [2052593] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Psychosocial functioning and cocaine use during treatment: strength of relationship depends on type of urine-testing method. AN - 68389080; 17624688 AB - Although improvement in psychosocial functioning is a common goal in substance-abuse treatment, the primary outcome measure in most cocaine trials is urinalysis-verified cocaine use. However, the relationship between cocaine use and psychosocial outcomes is not well documented. To investigate this relationship and identify the optimal urine-screen method, we retrospectively analyzed data from two 25-week randomized controlled trials of abstinence reinforcement (AR) in 368 cocaine/heroin users maintained on methadone. Cocaine use was measured thrice weekly by qualitative urinalysis, benzoylecgonine concentration (BE), and an estimate of New Uses of cocaine by application of an algorithm to BE. Social adjustment (SAS-SR), current diagnosis of cocaine dependence (DSM-IV criteria), and depression symptoms (Beck Depression Inventory) were determined at study exit. Cocaine use was significantly lower in AR groups than in controls. Across groups, in-treatment cocaine use was significantly associated with worse social adjustment, current cocaine dependence, and depression at exit. Significant differences were detected more frequently with New Uses than qualitative urinalysis or BE. Nevertheless, the amount of variance accounted for by the urine screens was typically <15%. Cocaine use during treatment, especially when measured with New Uses criteria, can predict psychosocial functioning, but cannot substitute for direct measures of psychosocial functioning. JF - Drug and alcohol dependence AU - Ghitza, Udi E AU - Epstein, David H AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Treatment Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), NIH/DHHS, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. ghitzau@intra.nida.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 169 EP - 177 VL - 91 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Heroin Dependence -- epidemiology KW - Cocaine -- urine KW - Social Adjustment KW - Humans KW - Patient Dropouts KW - Depression -- epidemiology KW - Adult KW - Reinforcement (Psychology) KW - Cocaine-Related Disorders -- psychology KW - Monitoring, Physiologic -- methods KW - Social Support KW - Cocaine-Related Disorders -- prevention & control KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68389080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Psychosocial+functioning+and+cocaine+use+during+treatment%3A+strength+of+relationship+depends+on+type+of+urine-testing+method.&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-12-01&rft.volume=91&rft.issue=2-3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-01 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Anal Toxicol. 2000 Oct;24(7):467-77 [11043648] Drug Alcohol Depend. 2009 Apr 1;101(1-2):92-100 [19101098] Int J Neurosci. 2001;106(3-4):253-63 [11264924] J Addict Dis. 2002;21(2):17-26 [11916369] J Consult Clin Psychol. 2002 Apr;70(2):398-405 [11952198] Drug Alcohol Depend. 2002 Jul 1;67(2):125-37 [12095662] J Subst Abuse Treat. 2002 Oct;23(3):171-81 [12392803] Exp Clin Psychopharmacol. 2003 Aug;11(3):195-201 [12940498] Am J Addict. 2004 Jan-Feb;13(1):74-82 [14766440] Arch Gen Psychiatry. 1976 Sep;33(9):1111-5 [962494] J Nerv Ment Dis. 1978 May;166(5):317-26 [650195] Arch Gen Psychiatry. 1981 Nov;38(11):1250-8 [7305605] J Nerv Ment Dis. 1983 Feb;171(2):97-104 [6822825] J Nerv Ment Dis. 1985 Jul;173(7):412-23 [4009158] J Neurol Neurosurg Psychiatry. 1985 Sep;48(9):876-81 [4045482] Arch Gen Psychiatry. 1986 Aug;43(8):739-45 [3729668] J Am Acad Child Adolesc Psychiatry. 1988 Jan;27(1):49-54 [3343206] Am J Psychiatry. 1991 Sep;148(9):1218-24 [1883001] J Affect Disord. 1991 Nov;23(3):137-49 [1774429] Am J Psychiatry. 1992 Sep;149(9):1148-56 [1386964] Int Psychogeriatr. 1992 Fall;4(2):177-85 [1477305] Drug Alcohol Depend. 2000 Apr 1;59(1):63-75 [10706976] J Affect Disord. 2000 Jan-Mar;57(1-3):261-5 [10708841] Drug Alcohol Depend. 1996 Jun;41(2):157-65 [8809505] Psychopharmacol Bull. 1995;31(4):671-9 [8851639] J Consult Clin Psychol. 1997 Apr;65(2):252-61 [9086688] Addiction. 1997 Mar;92(3):297-302 [9219391] NIDA Res Monogr. 1997;167:130-45 [9243560] Addiction. 1997 Jun;92(6):717-27 [9246799] NIDA Res Monogr. 1997;175:253-64 [9467803] J Consult Clin Psychol. 1998 Aug;66(4):691-6 [9735588] Am J Psychiatry. 1998 Oct;155(10):1446-8 [9766781] Biol Psychiatry. 2004 Nov 15;56(10):803-9 [15556126] Contemp Clin Trials. 2006 Feb;27(1):1-12 [16236557] J Anal Toxicol. 2006 Sep;30(7):458-62 [16959139] Am J Psychiatry. 2001 Mar;158(3):460-6 [11229989] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intratumoral delivery of vector mediated IL-2 in combination with vaccine results in enhanced T cell avidity and anti-tumor activity. AN - 68338267; 17503041 AB - Systemic IL-2 is currently employed in the therapy of several tumor types, but at the price of often severe toxicities. Local vector mediated delivery of IL-2 at the tumor site may enhance local effector cell activity while reducing toxicity. To examine this, a model using CEA-transgenic mice bearing established CEA expressing tumors was employed. The vaccine regimen was a s.c. prime vaccination with recombinant vaccinia (rV) expressing transgenes for CEA and a triad of costimulatory molecules (TRICOM) followed by i.t. boosting with rF-CEA/TRICOM. The addition of intratumoral (i.t.) delivery of IL-2 via a recombinant fowlpox (rF) IL-2 vector greatly enhanced anti-tumor activity of a recombinant vaccine, resulting in complete tumor regression in 70-80% of mice. The anti-tumor activity was shown to be dependent on CD8(+) cells and NK1.1(+). Cellular immune assays revealed that the addition of rF-IL-2 to the vaccination therapy enhanced CEA-specific tetramer(+) cell numbers, cytokine release and CTL lysis of CEA(+) targets. Moreover, tumor-bearing mice vaccinated with the CEA/TRICOM displayed an antigen cascade, i.e., CD8(+) T cell responses to two other antigens expressed on the tumor and not the vaccine: wild-type p53 and endogenous retroviral antigen gp70. Mice receiving rF-IL-2 during vaccination demonstrated higher avidity CEA-specific, as well as higher avidity gp70-specific, CD8(+) T cells when compared with mice vaccinated without rF-IL-2. These studies demonstrate for the first time that the level and avidity of antigen specific CTL, as well as the therapeutic outcome can be improved with the use of i.t. rF-IL-2 with vaccine regimens. JF - Cancer immunology, immunotherapy : CII AU - Kudo-Saito, Chie AU - Garnett, Charlie T AU - Wansley, Elizabeth K AU - Schlom, Jeffrey AU - Hodge, James W AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1750, USA. Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1897 EP - 1910 VL - 56 IS - 12 SN - 0340-7004, 0340-7004 KW - Cancer Vaccines KW - 0 KW - Interleukin-2 KW - Index Medicus KW - Animals KW - CD4-Positive T-Lymphocytes -- metabolism KW - CD8-Positive T-Lymphocytes -- immunology KW - Genetic Vectors KW - Mice, Inbred C57BL KW - Fowlpox -- microbiology KW - Mice KW - Flow Cytometry KW - Immune System KW - Interleukin-2 -- metabolism KW - Interleukin-2 -- therapeutic use KW - Genetic Therapy -- methods KW - Neoplasms -- therapy KW - T-Lymphocytes -- immunology KW - Neoplasms -- immunology KW - Immunotherapy -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Intratumoral+delivery+of+vector+mediated+IL-2+in+combination+with+vaccine+results+in+enhanced+T+cell+avidity+and+anti-tumor+activity.&rft.au=Kudo-Saito%2C+Chie%3BGarnett%2C+Charlie+T%3BWansley%2C+Elizabeth+K%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Kudo-Saito&rft.aufirst=Chie&rft.date=2007-12-01&rft.volume=56&rft.issue=12&rft.spage=1897&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammation and cancer: an ancient link with novel potentials. AN - 68334055; 17893866 AB - Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of the inflammatory response, e.g., cytokines, free radicals, prostaglandins and growth factors, can induce genetic and epigenetic changes including point mutations in tumor suppressor genes, DNA methylation and post-translational modifications, causing alterations in critical pathways responsible for maintaining the normal cellular homeostasis and leading to the development and progression of cancer. Recent discovery of an interaction between microRNAs and innate immunity during inflammation has further strengthened the association between inflammation and cancer. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Hussain, S Perwez AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD, USA. Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 2373 EP - 2380 VL - 121 IS - 11 KW - Cytokines KW - 0 KW - Free Radicals KW - Inflammation Mediators KW - Intercellular Signaling Peptides and Proteins KW - MicroRNAs KW - NF-kappa B KW - Prostaglandins KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Animals KW - Free Radicals -- adverse effects KW - Humans KW - Disease Progression KW - Cytokines -- metabolism KW - Immunity, Innate KW - Epigenesis, Genetic KW - Risk Assessment KW - DNA Methylation KW - Risk Factors KW - Genes, p53 -- genetics KW - Point Mutation KW - Chronic Disease KW - Cyclooxygenase 2 -- metabolism KW - Nitric Oxide Synthase -- metabolism KW - Signal Transduction KW - Prostaglandins -- metabolism KW - Intercellular Signaling Peptides and Proteins -- metabolism KW - NF-kappa B -- metabolism KW - Inflammation -- parasitology KW - Neoplasms -- virology KW - Inflammation -- virology KW - Inflammation Mediators -- adverse effects KW - Neoplasms -- microbiology KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Inflammation -- complications KW - Neoplasms -- metabolism KW - Neoplasms -- immunology KW - Inflammation Mediators -- metabolism KW - Inflammation -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68334055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Inflammation+and+cancer%3A+an+ancient+link+with+novel+potentials.&rft.au=Hussain%2C+S+Perwez%3BHarris%2C+Curtis+C&rft.aulast=Hussain&rft.aufirst=S&rft.date=2007-12-01&rft.volume=121&rft.issue=11&rft.spage=2373&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nitrate in public water supplies and the risk of renal cell carcinoma. AN - 68332393; 17717631 AB - Drinking water and dietary sources of nitrate and nitrite can react in vivo with amines and amides to form N-nitroso compounds (NOC), potent animal carcinogens. Nitrate is a widespread contaminant of drinking water supplies especially in agricultural areas. We conducted a population-based case-control study of renal cell carcinoma in 1986-1989 in Iowa, a state with elevated levels in many public water supplies. We collected a lifetime water source history, but due to limited monitoring data, most analyses focused on the subpopulation, who used Iowa public supplies with nitrate measurements (actual or imputed data) for > or = 70% of their person-years since 1960 (201 cases, 1,244 controls). We computed the average nitrate level and years using a public supply with nitrate levels >5 and >10 mg/l. Dietary nitrate and nitrite were estimated from a 55-item food frequency questionnaire. There was no association of renal cell carcinoma with the average nitrate level and years using public supplies >5 and >10 mg/l nitrate-nitrogen (10+ years >5 mg/l odds ratio (OR) = 1.03, 95% confidence interval (CI) 0.66, 1.60). However, higher nitrate exposure was associated with an increased risk among subgroups with above the median red meat intake (10+ years >5 mg/l OR = 1.91, 95% CI 1.04-3.51) or below the median vitamin C intake (10+ years >5 mg/l OR = 1.90, 95% CI 1.01, 3.56), dietary factors that increase the endogenous formation of NOC. Exclusion of long-term Des Moines residents, a large proportion of the high exposure categories, attenuated the association. These findings deserve additional study in populations with high water nitrate intake and information on dietary intakes. JF - Cancer causes & control : CCC AU - Ward, Mary H AU - Rusiecki, Jennifer A AU - Lynch, Charles F AU - Cantor, Kenneth P AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. wardm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1141 EP - 1151 VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Amines KW - 0 KW - Nitrates KW - Nitroso Compounds KW - Water Pollutants, Chemical KW - Water KW - 059QF0KO0R KW - Index Medicus KW - Nitroso Compounds -- metabolism KW - Humans KW - Amines -- metabolism KW - Retrospective Studies KW - Aged KW - Iowa KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Food Contamination KW - Middle Aged KW - Female KW - Male KW - Carcinoma, Renal Cell -- chemically induced KW - Kidney Neoplasms -- chemically induced KW - Water Pollutants, Chemical -- adverse effects KW - SEER Program KW - Nitrates -- metabolism KW - Water Supply KW - Kidney Neoplasms -- epidemiology KW - Nitrates -- adverse effects KW - Carcinoma, Renal Cell -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68332393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+causes+%26+control+%3A+CCC&rft.atitle=Nitrate+in+public+water+supplies+and+the+risk+of+renal+cell+carcinoma.&rft.au=Ward%2C+Mary+H%3BRusiecki%2C+Jennifer+A%3BLynch%2C+Charles+F%3BCantor%2C+Kenneth+P&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1141&rft.isbn=&rft.btitle=&rft.title=Cancer+causes+%26+control+%3A+CCC&rft.issn=09575243&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-11 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II clinical trial of ZD1839 (Iressa) in combination with docetaxel as first-line treatment in patients with advanced breast cancer. AN - 68326862; 17563856 AB - This was a phase II multi-institutional trial to determine the efficacy and tolerability of gefitinib (Iressatrade) and docetaxel as first-line treatment in patients with metastatic breast cancer. All patients had histologically confirmed breast cancer with metastatic disease. They were permitted to have received adjuvant chemotherapy, but no prior docetaxel or prior chemotherapy for metastatic disease. Patients received gefitinib 250 mg once daily and docetaxel 75 mg/m(2) every 3 weeks, until tumor progression, toxicity or other reasons for discontinuation. Thirty-three patients were enrolled and received a median of 5 cycles of treatment. The clinical benefit rate was 51.5% (95% CI: 33.5-69.2%). There were 1 confirmed complete response and 12 confirmed partial responses, and the overall objective response rate was 39.4% (95% CI: 22.9-57.9%). Four patients had stable disease for > or =24 weeks. The median duration of clinical benefit was 10.9 months (95% CI: 6.0-17.6 months). The most common reason for study discontinuation was disease progression (16 patients), followed by toxicity (ten patients). Toxicities were mainly attributable to docetaxel, including > or =grade 3 neutropenia in 43% of patients. The combination of gefitinib and docetaxel is an active regimen in patients with previously untreated metastatic breast cancer, with a clinical benefit rate and toxicity profile in the range of that reported for docetaxel alone. JF - Investigational new drugs AU - Dennison, Sheri K AU - Jacobs, Samuel A AU - Wilson, John W AU - Seeger, Janell AU - Cescon, Terrence P AU - Raymond, Jane M AU - Geyer, Charles E AU - Wolmark, Norman AU - Swain, Sandra M AD - Walter Reed Army Medical Center, 6900 Georgia Ave. NW, Washington, DC 20307, USA. dennisonsk@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 545 EP - 551 VL - 25 IS - 6 SN - 0167-6997, 0167-6997 KW - Quinazolines KW - 0 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - gefitinib KW - S65743JHBS KW - Index Medicus KW - Humans KW - Breast Neoplasms, Male -- drug therapy KW - Disease Progression KW - Aged KW - Neutropenia -- chemically induced KW - Taxoids -- administration & dosage KW - Breast Neoplasms, Male -- pathology KW - Quinazolines -- administration & dosage KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Female KW - Male KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68326862?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=A+phase+II+clinical+trial+of+ZD1839+%28Iressa%29+in+combination+with+docetaxel+as+first-line+treatment+in+patients+with+advanced+breast+cancer.&rft.au=Dennison%2C+Sheri+K%3BJacobs%2C+Samuel+A%3BWilson%2C+John+W%3BSeeger%2C+Janell%3BCescon%2C+Terrence+P%3BRaymond%2C+Jane+M%3BGeyer%2C+Charles+E%3BWolmark%2C+Norman%3BSwain%2C+Sandra+M&rft.aulast=Dennison&rft.aufirst=Sheri&rft.date=2007-12-01&rft.volume=25&rft.issue=6&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-25 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00052169; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Spousal concordance for substance use and anxiety disorders. AN - 68182937; 17204289 AB - Assortative mating -- the tendency for mate selection to occur on the basis of similar traits -- plays an essential role in understanding the genetic contribution to psychiatric illness. It also carries significant impact on clinical prognosis and is an important mechanism explaining spousal concordance. This study uses a family study design ascertaining 225 probands with substance abuse/dependence, anxiety disorders, and controls to address: (1) Is there spousal concordance or cross-concordance for substance use and/or anxiety disorders? (2) Is the spousal concordance or cross-concordance associated with worse clinical outcomes? (3) What is the mechanism of the concordance or cross-concordance? Results show a high magnitude of spousal concordance for substance use disorders with a third of the substance probands' spouses also substance dependent. In contrast, there was no spousal concordance for anxiety disorders. Couples were also concordant for having "no disorders." Both substance use and anxiety disorder concordance were associated with poorer global functioning and persistent illness. Assortative mating is a likely mechanism for spousal concordance given the elevated rate of substance use disorders among the relatives of spouses' of substance probands. Implications for family/genetic studies and the transmission of substance use disorders and "no disorders" include: (1) at the individual level, spousal concordance influences probands' course of illness, couples' marital functioning, and offspring's genetic and environmental context; and (2) at the population level, it shifts the general distribution of substance use disorders and "no disorders" by reducing the "average" couple concordance and increasing the number concordant and discordant couples at extremes of the distribution. JF - Journal of psychiatric research AU - Low, Nancy AU - Cui, Lihong AU - Merikangas, Kathleen R AD - Section on Developmental Genetic Epidemiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-3720, USA. Nancy.Low@nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 942 EP - 951 VL - 41 IS - 11 SN - 0022-3956, 0022-3956 KW - Index Medicus KW - Humans KW - Marriage -- statistics & numerical data KW - Comorbidity KW - Mood Disorders -- genetics KW - Phenotype KW - Interview, Psychological KW - Marriage -- psychology KW - Genetic Predisposition to Disease -- genetics KW - Risk Factors KW - Adult KW - Middle Aged KW - Mood Disorders -- epidemiology KW - Mood Disorders -- psychology KW - Female KW - Male KW - Anxiety Disorders -- genetics KW - Alcoholism -- epidemiology KW - Anxiety Disorders -- psychology KW - Spouses -- statistics & numerical data KW - Spouses -- psychology KW - Substance-Related Disorders -- psychology KW - Anxiety Disorders -- epidemiology KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+psychiatric+research&rft.atitle=Spousal+concordance+for+substance+use+and+anxiety+disorders.&rft.au=Low%2C+Nancy%3BCui%2C+Lihong%3BMerikangas%2C+Kathleen+R&rft.aulast=Low&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=41&rft.issue=11&rft.spage=942&rft.isbn=&rft.btitle=&rft.title=Journal+of+psychiatric+research&rft.issn=00223956&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mixed Race: Understanding Difference in the Genome Era AN - 61695244; 200823099 AB - This article presents the findings of a qualitative study of multiracial individuals' understanding of identity, race & human genetic variation. The debate regarding the correlation between race, genetics & disease has expanded, but limited empirical data has been collected regarding the lay public's perspective. Participants in this study explore their identity & its relationships to their health care interactions. Participants also share their views on race-based therapeutics, health disparities & the connections between race, ancestry & genetics. Their voices highlight the limitations of racial categories in describing differences within our increasingly diverse communities. The genomic era will be a pivotal period in challenging current understandings & uses of racial categories in health. Tables, References. Adapted from the source document. JF - Social Forces AU - Phillips, Elizabeth M AU - Odunlami, Adebola O AU - Bonham, Vence L AD - c/o Bonham -- Division Intramural Research, National Humkan Genome Research Instit, NIH, Bethesda, MD Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 795 EP - 820 PB - University of North Carolina Press, Chapel Hill VL - 86 IS - 2 SN - 0037-7732, 0037-7732 KW - Genetics KW - Classification KW - Multiraciality KW - Identity KW - article KW - 0410: group interactions; social group identity & intergroup relations (groups based on race & ethnicity, age, & sexual orientation) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61695244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Forces&rft.atitle=Mixed+Race%3A+Understanding+Difference+in+the+Genome+Era&rft.au=Phillips%2C+Elizabeth+M%3BOdunlami%2C+Adebola+O%3BBonham%2C+Vence+L&rft.aulast=Phillips&rft.aufirst=Elizabeth&rft.date=2007-12-01&rft.volume=86&rft.issue=2&rft.spage=795&rft.isbn=&rft.btitle=&rft.title=Social+Forces&rft.issn=00377732&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2008-09-03 N1 - Number of references - 59 N1 - Last updated - 2016-09-28 N1 - CODEN - SOFOAP N1 - SubjectsTermNotLitGenreText - Multiraciality; Identity; Genetics; Classification ER - TY - JOUR T1 - Kremlin Inc.: Gaming the Energy Landscape TT - Kremlin Inc.: le systeme juridique au service de l'industrie energetique AN - 59785972; 200805361 AB - The "come-back" of Russian power fuels speculation. The Kremlin seems to have a commercial predation policy, dedicated to its internal & foreign policy. A giant holding is emerging, systematically trying to control, upstream & downstream, the greatest part of the energy sector. Helped by numerous juridic advisors, it tries to trap capitalism with its own logic. Adapted from the source document. JF - Politique etrangere AU - Dellecker, Adrian AD - Centre Russie/NEI Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 851 EP - 862 PB - Armand Colin, France IS - 4 SN - 0032-342X, 0032-342X KW - Capitalism KW - Russia KW - Energy Policy KW - article KW - 9003: history and theory; political theories and philosophy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/59785972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awpsa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Politique+etrangere&rft.atitle=Kremlin+Inc.%3A+Gaming+the+Energy+Landscape&rft.au=Dellecker%2C+Adrian&rft.aulast=Dellecker&rft.aufirst=Adrian&rft.date=2007-12-01&rft.volume=&rft.issue=4&rft.spage=851&rft.isbn=&rft.btitle=&rft.title=Politique+etrangere&rft.issn=0032342X&rft_id=info:doi/ LA - French DB - Worldwide Political Science Abstracts N1 - Date revised - 2008-03-05 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Russia; Energy Policy; Capitalism ER - TY - JOUR T1 - Subtypes of alcohol dependence in a nationally representative sample AN - 57243271; 200810524 AB - Objective: The authors sought to empirically derive alcohol dependence (AD) subtypes based on clinical characteristics using data from a nationally representative epidemiological survey. Method A sample of 1484 respondents to the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) with past year AD was subjected to latent class analysis in order to identify homogeneous subtypes. Results The best-fitting model was a five-cluster solution. The largest cluster (Cluster 1: 31%) was comprised of young adults, who rarely sought help for drinking, had moderately high levels of periodic heavy drinking, relatively low rates of comorbidity, and the lowest rate of multigenerational AD (22%). In contrast, Clusters 4 and 5 (21% and 9%, respectively) had substantial rates of multigenerational AD (53% and 77%, respectively), had the most severe AD criteria profile, were associated with both comorbid psychiatric and other drug use disorders, lower levels of psychosocial functioning, and had engaged in significant help-seeking. Clusters 2 and 3 (19% each) had the latest onset, the lowest rates of periodic heavy drinking, medium/low levels of comorbidity, moderate levels of help-seeking, and higher psychosocial functioning. Conclusion Five distinct subtypes of AD were derived, distinguishable on the basis of family history, age of AD onset, endorsement of DSM-IV AUD criteria, and the presence of comorbid psychiatric and substance use disorders. These clinically relevant subtypes, derived from the general population, may enhance our understanding of the etiology, treatment, natural history, and prevention of AD and inform the DSM-V research agenda. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Moss, Howard B AU - Chen, Chiung M AU - Yi, Hsiao-ye AD - National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892, USA mossh@mail.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 149 EP - 158 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 91 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Alcohol dependence KW - Epidemiology KW - Subtypes KW - Survey research KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57243271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Subtypes+of+alcohol+dependence+in+a+nationally+representative+sample&rft.au=Moss%2C+Howard+B%3BChen%2C+Chiung+M%3BYi%2C+Hsiao-ye&rft.aulast=Moss&rft.aufirst=Howard&rft.date=2007-12-01&rft.volume=91&rft.issue=2-3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.05.016 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Subtypes; Alcohol dependence; Epidemiology DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.05.016 ER - TY - JOUR T1 - Research Knowledge Among the Participants in the Treatment for Adolescents With Depression Study (TADS) AN - 57241247; 200812953 AB - Objective: We examined the extent to which parents and adolescents participating in the Treatment for Adolescents With Depression Study (TADS) understood key aspects of the study. Method: TADS was a clinical trial comparing the effectiveness of fluoxetine, cognitive-behavioral therapy (CBT), their combination, and placebo in 439 adolescents (12-17 years old) with major depressive disorder. Six weeks after starting treatment, adolescents and their parents were asked to complete a questionnaire about critical elements of the trial. Results: Completion rate was 67.2% for adolescents -- N = 295) and 73.6% for parents (N = 323). More than 90% of the completers knew of the main purpose of the trial, possible assignment to placebo, and their right to withdraw participation at any time. However, about one third overall (and 49% in the CBT group) described TADS as "education" rather than "research." Of 12 questions, the mean number of correct answers was 10.3 (SD 1.7) among adolescents and 11.2 (SD 1.2) among parents (p < .0001). The most frequently stated reason for TADS participation was the pursuit of high-quality care. Conclusions: Most parents and adolescents were well-informed research participants. Difficulties in appreciating the research nature of the trial, however, emerged, especially among participants assigned to psychotherapy. Parents were overall better informed than adolescents. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AU - Kratochvil, Christopher J AU - Silva, Susan AU - Curry, John AU - Reinecke, Mark AU - Pathak, Sanjeev AU - Waslick, Bruce AU - Hughes, Carroll W AU - Prentice, Ernest D AU - May, Diane E AU - March, John S AD - National Institute of Mental Health, Room 7147, 6001 Executive Blvd., Bethesda, MD 20892-9633 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 1642 EP - 1650 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 46 IS - 12 SN - 0890-8567, 0890-8567 KW - depression, treatment, ethics KW - Fluoxetine KW - Cognitive behaviour therapy KW - Depression KW - Ethics KW - Parents KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57241247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Research+Knowledge+Among+the+Participants+in+the+Treatment+for+Adolescents+With+Depression+Study+%28TADS%29&rft.au=Vitiello%2C+Benedetto%3BKratochvil%2C+Christopher+J%3BSilva%2C+Susan%3BCurry%2C+John%3BReinecke%2C+Mark%3BPathak%2C+Sanjeev%3BWaslick%2C+Bruce%3BHughes%2C+Carroll+W%3BPrentice%2C+Ernest+D%3BMay%2C+Diane+E%3BMarch%2C+John+S&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-12-01&rft.volume=46&rft.issue=12&rft.spage=1642&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2Fchi.0b013e318153f8c7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Adolescents; Parents; Depression; Ethics; Cognitive behaviour therapy; Fluoxetine DO - http://dx.doi.org/10.1097/chi.0b013e318153f8c7 ER - TY - JOUR T1 - Donation Intentions among African American College Students: Decisional Balance and Self-efficacy Measures AN - 57235820; 200811665 AB - Although the need for transplantation among African Americans is high, their donation rates are disproportionately low. This study describes the development and validation of culturally adapted psychosocial measures, including Transtheoretical Model constructs, Stages of Change, Decisional Balance, and Self-efficacy, related to deceased organ and tissue donation for an African American college population. Exploratory and confirmatory analyses for Decisional Balance and Self-efficacy measures demonstrated factor structures similar to previous studies of other behavioral applications, indicated excellent model fit and showed good internal and external validity. This study developed brief measures with good psychometric properties for an emerging behavior change domain in a new population. Adapted from the source document. JF - Journal of Behavioral Medicine AU - Hall, Kara L AU - Robbins, Mark L AU - Paiva, Andrea AU - Knott, J Eugene AU - Harris, Lorna AU - Mattice, Burton AD - University of Rhode Island, Kingston, RI, USA hallka@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 483 EP - 495 PB - Springer Science+Business Media, Inc., Dordrecht, The Netherlands VL - 30 IS - 6 SN - 0160-7715, 0160-7715 KW - Selfefficacy KW - Black American people KW - Donations KW - Transtheoretical model KW - Transplants KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57235820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Behavioral+Medicine&rft.atitle=Donation+Intentions+among+African+American+College+Students%3A+Decisional+Balance+and+Self-efficacy+Measures&rft.au=Hall%2C+Kara+L%3BRobbins%2C+Mark+L%3BPaiva%2C+Andrea%3BKnott%2C+J+Eugene%3BHarris%2C+Lorna%3BMattice%2C+Burton&rft.aulast=Hall&rft.aufirst=Kara&rft.date=2007-12-01&rft.volume=30&rft.issue=6&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Journal+of+Behavioral+Medicine&rft.issn=01607715&rft_id=info:doi/10.1007%2Fs10865-007-9121-8 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JBMEDD N1 - SubjectsTermNotLitGenreText - Undergraduate students; Transplants; Donations; Selfefficacy; Black American people; Transtheoretical model DO - http://dx.doi.org/10.1007/s10865-007-9121-8 ER - TY - CPAPER T1 - Neuromuscular Junction Defects in Emery-Dreyfuss Muscular Dystrophy T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39774072; 4738741 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mejat, A AU - Decostre, V AU - Kesari, A AU - Hoffman, E AU - Bonne, G AU - Stewart, C L AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Muscular dystrophy KW - Neuromuscular junctions KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39774072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Neuromuscular+Junction+Defects+in+Emery-Dreyfuss+Muscular+Dystrophy&rft.au=Mejat%2C+A%3BDecostre%2C+V%3BKesari%2C+A%3BHoffman%2C+E%3BBonne%2C+G%3BStewart%2C+C+L%3BMisteli%2C+T&rft.aulast=Mejat&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dictyostelium Chemotaxis is Regulated and Sensitized by Extracellular Signal Degradation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39773452; 4738596 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Garcia, G L AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chemotaxis KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39773452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dictyostelium+Chemotaxis+is+Regulated+and+Sensitized+by+Extracellular+Signal+Degradation&rft.au=Garcia%2C+G+L%3BParent%2C+C+A&rft.aulast=Garcia&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Mammalian Polo-like Kinase 1 (Plk1) Localization: Self- versus Non-self-Priming T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39772417; 4738829 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Park, J AU - Kang, Y AU - Erikson, R AU - Lee, K S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39772417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mechanisms+of+Mammalian+Polo-like+Kinase+1+%28Plk1%29+Localization%3A+Self-+versus+Non-self-Priming&rft.au=Park%2C+J%3BKang%2C+Y%3BErikson%2C+R%3BLee%2C+K+S&rft.aulast=Park&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Dynamin Family Members Offers Insight into Membrane Fission T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39771280; 4739016 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mears, J A AU - Ray, P AU - Fang, S AU - Hinshaw, J E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structural analysis KW - Membranes KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39771280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Structural+Analysis+of+Dynamin+Family+Members+Offers+Insight+into+Membrane+Fission&rft.au=Mears%2C+J+A%3BRay%2C+P%3BFang%2C+S%3BHinshaw%2C+J+E&rft.aulast=Mears&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAM Proteins Function in ER-to-Golgi Trafficking through Interactions with COPII Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39767272; 4740280 DE: JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rismanchi, N AU - Puertollano, R AU - Blackstone, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=STAM+Proteins+Function+in+ER-to-Golgi+Trafficking+through+Interactions+with+COPII+Complexes&rft.au=Rismanchi%2C+N%3BPuertollano%2C+R%3BBlackstone%2C+C&rft.aulast=Rismanchi&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arf6 and Arf1 Interact with the Plasma Membrane t-SNARE Syntaxin 4 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39767006; 4740256 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Eyster, C A AU - Honda, A AU - Weigert, R AU - Donaldson, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Plasma membranes KW - Syntaxin 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39767006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Arf6+and+Arf1+Interact+with+the+Plasma+Membrane+t-SNARE+Syntaxin+4&rft.au=Eyster%2C+C+A%3BHonda%2C+A%3BWeigert%2C+R%3BDonaldson%2C+J+G&rft.aulast=Eyster&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brucella Intracellular Replication Requires Trafficking through the Late Endocytic/Lysosomal Compartment T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39719323; 4741069 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Starr, T AU - Ng, T W AU - Wehrly, T D AU - Knodler, L A AU - Celli, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Replication KW - Brucella KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39719323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Brucella+Intracellular+Replication+Requires+Trafficking+through+the+Late+Endocytic%2FLysosomal+Compartment&rft.au=Starr%2C+T%3BNg%2C+T+W%3BWehrly%2C+T+D%3BKnodler%2C+L+A%3BCelli%2C+J&rft.aulast=Starr&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Characterization, Expression, and Functional Analyses of LdNucs: A Novel Class-I Secretory Nuclease from the Human Pathogen Leishmania donovani T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39718759; 4740998 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Joshi, M B AU - Owings, J P AU - Dwyer, D M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pathogens KW - Functional analysis KW - Nuclease KW - Leishmania donovani KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39718759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Molecular+Characterization%2C+Expression%2C+and+Functional+Analyses+of+LdNucs%3A+A+Novel+Class-I+Secretory+Nuclease+from+the+Human+Pathogen+Leishmania+donovani&rft.au=Joshi%2C+M+B%3BOwings%2C+J+P%3BDwyer%2C+D+M&rft.aulast=Joshi&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Histone Modifications Surrounding a Suppressor of Hairy Wing Chromatin Insulator T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39695277; 4740862 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Emmett, M J AU - Lei, E P Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Wings KW - Histones KW - Chromatin KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Analysis+of+Histone+Modifications+Surrounding+a+Suppressor+of+Hairy+Wing+Chromatin+Insulator&rft.au=Emmett%2C+M+J%3BLei%2C+E+P&rft.aulast=Emmett&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin-mediated Endocytosis is Required for Sea Urchin Embryo Cytokinesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39695057; 4740835 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Covian-Nares, J F AU - Vogel, S S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Embryos KW - Endocytosis KW - Cytokinesis KW - Marine invertebrates KW - Echinoidea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamin-mediated+Endocytosis+is+Required+for+Sea+Urchin+Embryo+Cytokinesis&rft.au=Covian-Nares%2C+J+F%3BVogel%2C+S+S&rft.aulast=Covian-Nares&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Histone Modifications in Epigenetic Control of Nodal Gene Expression T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39685300; 4739233 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Dahle, O AU - Kuehn, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Histones KW - Nodal gene KW - Epigenetics KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39685300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Role+of+Histone+Modifications+in+Epigenetic+Control+of+Nodal+Gene+Expression&rft.au=Dahle%2C+O%3BKuehn%2C+M&rft.aulast=Dahle&rft.aufirst=O&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Caspase-dependent Cleavage Disrupts the ERK Scaffolding Function of KSR1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39681949; 4741001 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McKay, M AU - Morrison, D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Extracellular signal-regulated kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39681949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Caspase-dependent+Cleavage+Disrupts+the+ERK+Scaffolding+Function+of+KSR1&rft.au=McKay%2C+M%3BMorrison%2C+D&rft.aulast=McKay&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simulated Diffusion of CaMKII in Dendritic Spines T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39677750; 4741097 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yixiao, Z AU - Reese, T AU - Khan, S M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Diffusion KW - Dendritic spines KW - Ca super(2+)/calmodulin-dependent protein kinase II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39677750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Simulated+Diffusion+of+CaMKII+in+Dendritic+Spines&rft.au=Yixiao%2C+Z%3BReese%2C+T%3BKhan%2C+S+M&rft.aulast=Yixiao&rft.aufirst=Z&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Smad3 by GSK3-mediated Phosphorylation at its Linker Region T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39674582; 4739733 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Millet, C A AU - Yamashita, M AU - Yu, L. AU - Veenstra, T AU - Heller, M AU - Zhang, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Phosphorylation KW - Smad3 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39674582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Regulation+of+Smad3+by+GSK3-mediated+Phosphorylation+at+its+Linker+Region&rft.au=Millet%2C+C+A%3BYamashita%2C+M%3BYu%2C+L.%3BVeenstra%2C+T%3BHeller%2C+M%3BZhang%2C+Y&rft.aulast=Millet&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantification of Nonmuscle Myosin II Heavy Chain Isoforms Using Mass Spectroscopy T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39656879; 4740474 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Conti, M AU - Zhang, Y AU - Wang, G AU - Shen, R AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mass spectroscopy KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39656879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Quantification+of+Nonmuscle+Myosin+II+Heavy+Chain+Isoforms+Using+Mass+Spectroscopy&rft.au=Conti%2C+M%3BZhang%2C+Y%3BWang%2C+G%3BShen%2C+R%3BAdelstein%2C+R+S&rft.aulast=Conti&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Palmitoylation is Required for the Retrograde Transport of the Lysosomal Sorting Receptors T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39641468; 4740981 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McCormick, P J AU - Dumaresq-Doiron, K AU - Pluviose, A AU - Lefrancois, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Palmitoylation KW - Retrograde transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39641468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft.genre=dissertations+%26+theses&rft.jtitle=&rft.atitle=&rft.au=Xu%2C+Long&rft.aulast=Xu&rft.aufirst=Long&rft.date=1987-01-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Su+Shi%3A+Major+Creative+and+Critical+Insights+and+Theories&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Insulin and CL316243 (b3-Receptor Agonist) on Activation of Adipocyte PDE3B Associated with Caveolae and Internal Membranes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39637516; 4740855 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Khan, F A AU - Lindh, R AU - Degerman, E AU - Tang, Y AU - Manganiello, V Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Insulin KW - Caveolae KW - Adipocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+Insulin+and+CL316243+%28b3-Receptor+Agonist%29+on+Activation+of+Adipocyte+PDE3B+Associated+with+Caveolae+and+Internal+Membranes&rft.au=Khan%2C+F+A%3BLindh%2C+R%3BDegerman%2C+E%3BTang%2C+Y%3BManganiello%2C+V&rft.aulast=Khan&rft.aufirst=F&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oxysterol Binding Protein Homologs Localize to Organellar Junctions and Mediate Contacts with Lipid Droplets T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39637478; 4740829 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Schulz, T A AU - Prinz, W A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lipids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39637478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=A+role+for+conditioned+ventral+tegmental+glutamate+release+in+cocaine+seeking.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BAzari%2C+Soraya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2007-09-26&rft.volume=27&rft.issue=39&rft.spage=10546&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Homologous Recombination to Replace Nonmuscle Myosin II-A with Human GFP-Myosin II-B in Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636905; 4740472 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wang, A AU - Ma, X. AU - Liu, C AU - Pinto, Y AU - Adelstein, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - Myosin KW - Homologous recombination KW - Recombination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Pater%27s+Critical+Foresight%3A+Style%2C+Insight+and+Complexity&rft.au=De+Scarpis%2C+Valerio&rft.aulast=De+Scarpis&rft.aufirst=Valerio&rft.date=1996-01-01&rft.volume=&rft.issue=&rft.spage=215&rft.isbn=9788820507831&rft.btitle=Walter+Pater+%281839-1894%29%3A+Le+forme+della+modernit%C3%A0%2FThe+Forms+of+Modernity&rft.title=Walter+Pater+%281839-1894%29%3A+Le+forme+della+modernit%C3%A0%2FThe+Forms+of+Modernity&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Vertebrate Nup93 Nuclear Pore Sub-complex T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636890; 4740894 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yoon, H AU - Quimby, B AU - Arnaoutov, A AU - Dasso, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclear pores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+the+Vertebrate+Nup93+Nuclear+Pore+Sub-complex&rft.au=Yoon%2C+H%3BQuimby%2C+B%3BArnaoutov%2C+A%3BDasso%2C+M&rft.aulast=Yoon&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Imaging of Receptor-G Protein Interactions: Single-Molecule Microscopy Reveals Dynamic Interactions between Chemoattractant GPCR and Heterotrimeric G-proteins in Membrane of Living Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636664; 4740811 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Xu, X. AU - Brzostowski, J A AU - Meckel, T AU - Tolar, P AU - Yan, J AU - Jin, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Microscopy KW - Chemotactic factors KW - Protein interaction KW - Imaging techniques KW - G protein-coupled receptors KW - Guanine nucleotide-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Imaging+of+Receptor-G+Protein+Interactions%3A+Single-Molecule+Microscopy+Reveals+Dynamic+Interactions+between+Chemoattractant+GPCR+and+Heterotrimeric+G-proteins+in+Membrane+of+Living+Cells&rft.au=Xu%2C+X.%3BBrzostowski%2C+J+A%3BMeckel%2C+T%3BTolar%2C+P%3BYan%2C+J%3BJin%2C+T&rft.aulast=Xu&rft.aufirst=X.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pin1 Dependent Prolyl Isomerization Modulates the Stress Induced Phosphorylation of NF-H: A Role in Neurodegenerative Disorders T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39636086; 4740515 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rudrabhatla, P AU - Zheng, Y AU - Amin, N AU - Grant, P AU - Albers, W AU - Kesavapany, S AU - Pant, H C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stress KW - Neurodegenerative diseases KW - Isomerization KW - Pin1 protein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39636086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Pin1+Dependent+Prolyl+Isomerization+Modulates+the+Stress+Induced+Phosphorylation+of+NF-H%3A+A+Role+in+Neurodegenerative+Disorders&rft.au=Rudrabhatla%2C+P%3BZheng%2C+Y%3BAmin%2C+N%3BGrant%2C+P%3BAlbers%2C+W%3BKesavapany%2C+S%3BPant%2C+H+C&rft.aulast=Rudrabhatla&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imbalanced Expression and Mis-localization of Histone H3 and its Variant Cse4p Lead to Defects in Chromosome Transmission Fidelity T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39635818; 4739668 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Au, W. AU - DeLuca, S AU - Crisp, M AU - Rando, O AU - Basrai, M A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lead KW - Chromosomes KW - Fidelity KW - Histone H3 KW - Defects KW - Histones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39635818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Imbalanced+Expression+and+Mis-localization+of+Histone+H3+and+its+Variant+Cse4p+Lead+to+Defects+in+Chromosome+Transmission+Fidelity&rft.au=Au%2C+W.%3BDeLuca%2C+S%3BCrisp%2C+M%3BRando%2C+O%3BBasrai%2C+M+A&rft.aulast=Au&rft.aufirst=W.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coupling of Inositol Pyrophosphates Signal and High Energy Balance is Independent of AMP-activated Protein Kinase T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634411; 4739722 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mollapour, E AU - Choi, K AU - Shears, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pyrophosphates KW - Inositol KW - Energy balance KW - AMP-activated protein kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Coupling+of+Inositol+Pyrophosphates+Signal+and+High+Energy+Balance+is+Independent+of+AMP-activated+Protein+Kinase&rft.au=Mollapour%2C+E%3BChoi%2C+K%3BShears%2C+S&rft.aulast=Mollapour&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Studies of Movement of DNA Sites in Yeast Nuclei T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634409; 4740120 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Campbell, J L AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Studies+of+Movement+of+DNA+Sites+in+Yeast+Nuclei&rft.au=Campbell%2C+J+L%3BCohen-Fix%2C+O&rft.aulast=Campbell&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Nesprin-1 Isoforms Localize to the Nucleolus and Disrupt the Formation of Cytoplasmic Processing Bodies T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39634225; 4740118 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mellad, J A AU - Boem, M AU - Shanahan, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nucleoli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39634225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Novel+Nesprin-1+Isoforms+Localize+to+the+Nucleolus+and+Disrupt+the+Formation+of+Cytoplasmic+Processing+Bodies&rft.au=Mellad%2C+J+A%3BBoem%2C+M%3BShanahan%2C+C&rft.aulast=Mellad&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cells Increase the Number and Adhesiveness of Their "Sticky Fingers" as They Turn Toward Permissive Substrates T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633841; 4739592 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Galbraith, J AU - Galbraith, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cells+Increase+the+Number+and+Adhesiveness+of+Their+%22Sticky+Fingers%22+as+They+Turn+Toward+Permissive+Substrates&rft.au=Galbraith%2C+J%3BGalbraith%2C+C&rft.aulast=Galbraith&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Direct Observation of the Uncapping of Capped Actin Filaments by CARMIL T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633507; 4740686 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fujiwara, I AU - Remmert, K AU - Hammer, J A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Actin KW - Filaments KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Direct+Observation+of+the+Uncapping+of+Capped+Actin+Filaments+by+CARMIL&rft.au=Fujiwara%2C+I%3BRemmert%2C+K%3BHammer%2C+J+A&rft.aulast=Fujiwara&rft.aufirst=I&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intercellular Transfer as a Mechanism of Cell Communication within the Hematopoietic Progenitor Niche T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39633401; 4740610 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gillette, J M AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Niches KW - Communication KW - Hemopoiesis KW - Cell interactions KW - Intercellular signalling KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39633401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Intercellular+Transfer+as+a+Mechanism+of+Cell+Communication+within+the+Hematopoietic+Progenitor+Niche&rft.au=Gillette%2C+J+M%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2007-12-01&rft.volume=4&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Pedagogy%3A+Critical+Approaches+to+Teaching+Literature%2C+Language%2C+Composition%2C+and+Culture&rft.issn=15314200&rft_id=info:doi/10.1215%2F15314200-4-2-215 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Formation of Artificial Bone Scaffolds with Surface-modified Hydroxyapatite Crystals and Polyamine Organic Polymer for Bone Regeneration T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631845; 4741113 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lee, E AU - Sworder, B AU - Leet, A AU - Jeon, E AU - Son, Y AU - Yoon, K AU - Robey, P G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Bone growth KW - Regeneration KW - Polymers KW - Scaffolds KW - Crystals KW - Hydroxyapatite KW - Polyamines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Formation+of+Artificial+Bone+Scaffolds+with+Surface-modified+Hydroxyapatite+Crystals+and+Polyamine+Organic+Polymer+for+Bone+Regeneration&rft.au=Lee%2C+E%3BSworder%2C+B%3BLeet%2C+A%3BJeon%2C+E%3BSon%2C+Y%3BYoon%2C+K%3BRobey%2C+P+G&rft.aulast=Lee&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Arylcarbonlyindoles: Antimitotic Agents and Potent Inhibitors of Tubulin Polymerization T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631356; 4740711 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sarkar, T AU - Regina, G La AU - Silvestri, R AU - Hamel, E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Antimitotic agents KW - Tubulin KW - Polymerization KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Modulating+protein+alignment+in+a+liquid-crystalline+medium+through+conservative+mutagenesis.&rft.au=Davis%2C+Lennard+J&rft.aulast=Davis&rft.aufirst=Lennard&rft.date=1995-12-01&rft.volume=57&rft.issue=8&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=College+English&rft.issn=00100994&rft_id=info:doi/10.2307%2F378619 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Zinc Regulation of the Candida albicans Developmental Regulator HBR1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631275; 4738710 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pendrak, M L AU - Roberts, D D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Zinc KW - Candida albicans KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Zinc+Regulation+of+the+Candida+albicans+Developmental+Regulator+HBR1&rft.au=Pendrak%2C+M+L%3BRoberts%2C+D+D&rft.aulast=Pendrak&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Serpinin, a Novel Chromogranin A (CgA)-derived Peptide Induces Granule Biogenesis in Endocrine Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39631042; 4738948 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Koshimizu, H AU - Kim, T AU - Loh, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chromogranins KW - Granules KW - Biogenesis KW - Endocrinology KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Serpinin%2C+a+Novel+Chromogranin+A+%28CgA%29-derived+Peptide+Induces+Granule+Biogenesis+in+Endocrine+Cells&rft.au=Koshimizu%2C+H%3BKim%2C+T%3BLoh%2C+Y&rft.aulast=Koshimizu&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamin's Role in Apical Constriction T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39629327; 4740480 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chua, J AU - Rikhy, R AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39629327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamin%27s+Role+in+Apical+Constriction&rft.au=Chua%2C+J%3BRikhy%2C+R%3BLippincott-Schwartz%2C+J&rft.aulast=Chua&rft.aufirst=J&rft.date=2007-12-01&rft.volume=4&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of an Alternatively Spliced Isoform of Nonmuscle Myosin II-C, NMHC II-C2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39629297; 4740469 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Jana, S S AU - Kim, K AU - Kawamoto, S AU - Sellers, J R AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Alternative splicing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39629297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+an+Alternatively+Spliced+Isoform+of+Nonmuscle+Myosin+II-C%2C+NMHC+II-C2&rft.au=Jana%2C+S+S%3BKim%2C+K%3BKawamoto%2C+S%3BSellers%2C+J+R%3BAdelstein%2C+R+S&rft.aulast=Jana&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - cAMP Dynamics in Chemotactic Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628924; 4738597 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bagorda, A AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cyclic AMP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=bookitem&rft.jtitle=&rft.atitle=Manuel+Manrique+de+Lara+and+the+Tunes+of+the+Moroccan+Sephardic+Ballad+Tradition%3A+Some+Insights+into+a+Much-Needed+Critical+Edition&rft.au=Katz%2C+Israel+J&rft.aulast=Katz&rft.aufirst=Israel&rft.date=1979-01-01&rft.volume=&rft.issue=&rft.spage=75&rft.isbn=&rft.btitle=El+romancero+hoy%3A+Nuevas+fronteras%2FThe+Hispanic+Ballad+Today%3A+New+Frontiers&rft.title=El+romancero+hoy%3A+Nuevas+fronteras%2FThe+Hispanic+Ballad+Today%3A+New+Frontiers&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA Receptors Interact with Flotillin-1, a Lipid Raft-associated Protein T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628844; 4738951 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Swanwick, C AU - Shapiro, M E AU - Yi, Z. AU - Chang, K AU - Wenthold, R J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Lipids KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=NMDA+Receptors+Interact+with+Flotillin-1%2C+a+Lipid+Raft-associated+Protein&rft.au=Swanwick%2C+C%3BShapiro%2C+M+E%3BYi%2C+Z.%3BChang%2C+K%3BWenthold%2C+R+J&rft.aulast=Swanwick&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carbon Monoxide Repression of Interleukin-1beta Transcription in THP-1 Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628722; 4740013 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chhikara, M AU - Wang, S AU - Danner, R L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Carbon monoxide KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Carbon+Monoxide+Repression+of+Interleukin-1beta+Transcription+in+THP-1+Cells&rft.au=Chhikara%2C+M%3BWang%2C+S%3BDanner%2C+R+L&rft.aulast=Chhikara&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Regulated Secretion in Three-Dimensionally Grown Human Submandibular Gland Cell (HSG) T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628367; 4739297 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Aye, M AU - Weigert, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Secretion KW - Submandibular gland KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+Regulated+Secretion+in+Three-Dimensionally+Grown+Human+Submandibular+Gland+Cell+%28HSG%29&rft.au=Aye%2C+M%3BWeigert%2C+R&rft.aulast=Aye&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Architecture of the Retromer Cargo-Recognition Complex T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628310; 4739286 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hierro, A AU - Rojas, A L AU - Rojas, R AU - Murthy, M AU - Effantin, G AU - Kajava, A V AU - Steven, A C AU - Bonifacino, J S AU - Hurley, J H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structure-function relationships KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Functional+Architecture+of+the+Retromer+Cargo-Recognition+Complex&rft.au=Hierro%2C+A%3BRojas%2C+A+L%3BRojas%2C+R%3BMurthy%2C+M%3BEffantin%2C+G%3BKajava%2C+A+V%3BSteven%2C+A+C%3BBonifacino%2C+J+S%3BHurley%2C+J+H&rft.aulast=Hierro&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Role of Protein Arginine Methytransferase 1 in the Transcriptional Regulation by Thyroid Hormone Receptor during Xenopus metamorphosis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628309; 4739234 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Matsuda, H AU - Paul, B AU - Choi, C AU - Shi, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Metamorphosis KW - Hormones KW - Thyroid hormone receptors KW - Transcription KW - Gene regulation KW - Arginine KW - Life cycle KW - Amphibiotic species KW - Xenopus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Role+of+Protein+Arginine+Methytransferase+1+in+the+Transcriptional+Regulation+by+Thyroid+Hormone+Receptor+during+Xenopus+metamorphosis&rft.au=Matsuda%2C+H%3BPaul%2C+B%3BChoi%2C+C%3BShi%2C+Y&rft.aulast=Matsuda&rft.aufirst=H&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of RNAi Screens in the Study of Cancer-associated Processes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39628090; 4740603 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Martin, S E AU - Jones, T L AU - Lorenzi, P AU - Lader, E AU - Weinstein, J AU - Pommier, Y AU - Huppi, K AU - Caplen, N J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Literary+Semantics&rft.atitle=Exploring+Image+Schemas+as+a+Critical+Concept%3A+Toward+a+Critical-Cognitive+Linguistic+Account+of+Image-Schematic+Interactions&rft.au=Tseng%2C+Ming-Yu&rft.aulast=Tseng&rft.aufirst=Ming-Yu&rft.date=2007-10-01&rft.volume=36&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Journal+of+Literary+Semantics&rft.issn=03417638&rft_id=info:doi/10.1515%2FJLS.2007.008 L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Complexity of Phosphorylated H2AX Foci and DNA Repair Protein Assembly at DNA Double-stranded Breaks T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39627455; 4738999 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bonner, W AU - Nakamura, A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Double-strand break repair KW - DNA damage KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39627455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Complexity+of+Phosphorylated+H2AX+Foci+and+DNA+Repair+Protein+Assembly+at+DNA+Double-stranded+Breaks&rft.au=Bonner%2C+W%3BNakamura%2C+A&rft.aulast=Bonner&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vesicular Trafficking and Protein Synthesis are Required for Streaming during Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39627373; 4738989 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kriebel, P W AU - Barr, V A AU - Zhang, G AU - Parent, C A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Protein synthesis KW - Protein biosynthesis KW - Protein transport KW - Streaming KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39627373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Vesicular+Trafficking+and+Protein+Synthesis+are+Required+for+Streaming+during+Chemotaxis&rft.au=Kriebel%2C+P+W%3BBarr%2C+V+A%3BZhang%2C+G%3BParent%2C+C+A&rft.aulast=Kriebel&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of Dynamin Domains T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39626316; 4739271 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ray, P AU - Fang, S AU - Mears, J A AU - Hinshaw, J E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Structural analysis KW - Dynamin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39626316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Structural+Analysis+of+Dynamin+Domains&rft.au=Ray%2C+P%3BFang%2C+S%3BMears%2C+J+A%3BHinshaw%2C+J+E&rft.aulast=Ray&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photoactivatible Thresholding: Seeing More by Seeing Less T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623904; 4739585 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Galbraith, C AU - Galbraith, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Photoactivatible+Thresholding%3A+Seeing+More+by+Seeing+Less&rft.au=Galbraith%2C+C%3BGalbraith%2C+J&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Activity Regulates Myosin Phosphorylation and Cell Migration in Lens Epithelial Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623770; 4740478 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Tripathi, B K AU - Zelenka, P S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - Cell migration KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cdk5+Activity+Regulates+Myosin+Phosphorylation+and+Cell+Migration+in+Lens+Epithelial+Cells&rft.au=Tripathi%2C+B+K%3BZelenka%2C+P+S&rft.aulast=Tripathi&rft.aufirst=B&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The AP4 Complex Mediates Sorting of the Amyloid Precursor Protein at the trans-Golgi Network T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623286; 4739005 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Burgos, P V AU - Mardones, G A AU - daSilva, L L AU - Smith, W J AU - Prabhu, Y AU - Bonifacino, J S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Alzheimer's disease KW - Amyloid precursor protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+AP4+Complex+Mediates+Sorting+of+the+Amyloid+Precursor+Protein+at+the+trans-Golgi+Network&rft.au=Burgos%2C+P+V%3BMardones%2C+G+A%3BdaSilva%2C+L+L%3BSmith%2C+W+J%3BPrabhu%2C+Y%3BBonifacino%2C+J+S&rft.aulast=Burgos&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - G1 to S Phase Cell Cycle Progression Requires a Single Electrically-coupled Mitochondrial Network with a Continuous Lumen T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39623164; 4738982 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Mitra, K AU - Roysam, B AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mitochondria KW - Cell cycle KW - S phase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39623164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=G1+to+S+Phase+Cell+Cycle+Progression+Requires+a+Single+Electrically-coupled+Mitochondrial+Network+with+a+Continuous+Lumen&rft.au=Mitra%2C+K%3BRoysam%2C+B%3BLippincott-Schwartz%2C+J&rft.aulast=Mitra&rft.aufirst=K&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GLA Gene Silencing and Fabry Disease T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622840; 4738700 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kim, M J AU - Luu, N AU - Kaneski, C R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Gene silencing KW - Fabry's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=GLA+Gene+Silencing+and+Fabry+Disease&rft.au=Kim%2C+M+J%3BLuu%2C+N%3BKaneski%2C+C+R&rft.aulast=Kim&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Remodeling of Primary Cilia Membranes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622620; 4738643 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ott, C M AU - Lippincott-Schwartz, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Membranes KW - Cilia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Remodeling+of+Primary+Cilia+Membranes&rft.au=Ott%2C+C+M%3BLippincott-Schwartz%2C+J&rft.aulast=Ott&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Topologic Structure of Transmembrane Channel-like Gene 1 Protein TMC1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39622097; 4739312 DE: JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Labay, V AU - Weichert, R M AU - Makishima, T AU - Griffith, A J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Topologic+Structure+of+Transmembrane+Channel-like+Gene+1+Protein+TMC1&rft.au=Labay%2C+V%3BWeichert%2C+R+M%3BMakishima%2C+T%3BGriffith%2C+A+J&rft.aulast=Labay&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of CDKN1A Expression in Keratinocytes by Distal-less 3 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621967; 4740645 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pietroni, V AU - Radoja, N AU - Rivera, Y AU - Stimpson, S J AU - Anderson, E D AU - Blumenberg, M AU - Morasso, M I Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Regulation+of+CDKN1A+Expression+in+Keratinocytes+by+Distal-less+3&rft.au=Pietroni%2C+V%3BRadoja%2C+N%3BRivera%2C+Y%3BStimpson%2C+S+J%3BAnderson%2C+E+D%3BBlumenberg%2C+M%3BMorasso%2C+M+I&rft.aulast=Pietroni&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Clathrin-Independent Endocytic Pathway as a Novel Platform for H-Ras Trafficking and Signaling T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621820; 4738489 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Porat-Shliom, N AU - Kloog, Y AU - Donaldson, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - H-Ras protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Clathrin-Independent+Endocytic+Pathway+as+a+Novel+Platform+for+H-Ras+Trafficking+and+Signaling&rft.au=Porat-Shliom%2C+N%3BKloog%2C+Y%3BDonaldson%2C+J&rft.aulast=Porat-Shliom&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drosophila Myosin V T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621688; 4739147 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hong, A AU - Toth, J AU - Sellers, J R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Drosophila+Myosin+V&rft.au=Hong%2C+A%3BToth%2C+J%3BSellers%2C+J+R&rft.aulast=Hong&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Understanding the Biological Significance of Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Internalization and Nuclear Translocation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621524; 4739063 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sivendran, R AU - Xiao, Z AU - Veenstra, T D AU - Stetler-Stevenson, W G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Translocation KW - Tissue inhibitor of metalloproteinase 2 KW - Nuclear transport KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Understanding+the+Biological+Significance+of+Tissue+Inhibitor+of+Metalloproteinase-2+%28TIMP-2%29+Internalization+and+Nuclear+Translocation&rft.au=Sivendran%2C+R%3BXiao%2C+Z%3BVeenstra%2C+T+D%3BStetler-Stevenson%2C+W+G&rft.aulast=Sivendran&rft.aufirst=R&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Myosin II-induced Maturation of Focal Adhesions T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39621263; 4738993 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pasapera-Limon, A AU - Schneider, I AU - Waterman, C M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Adhesion KW - Myosin KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Analysis+of+Myosin+II-induced+Maturation+of+Focal+Adhesions&rft.au=Pasapera-Limon%2C+A%3BSchneider%2C+I%3BWaterman%2C+C+M&rft.aulast=Pasapera-Limon&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Different Erythopoietic and Immune Responses on the Outcome of Human Malaria: Insight from Numerical Studies T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620671; 4739488 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McQueen, P G AU - McKenzie, F E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Malaria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+Different+Erythopoietic+and+Immune+Responses+on+the+Outcome+of+Human+Malaria%3A+Insight+from+Numerical+Studies&rft.au=McQueen%2C+P+G%3BMcKenzie%2C+F+E&rft.aulast=McQueen&rft.aufirst=P&rft.date=2007-12-01&rft.volume=62&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SENP3 and SENP5 SUMO Proteases Regulate Ribosome Biogenesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620581; 4740888 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yun, C AU - Wang, Y AU - Mukhopadhyay, D AU - Dasso, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Ribosomes KW - Proteinase KW - Biogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620581?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=SENP3+and+SENP5+SUMO+Proteases+Regulate+Ribosome+Biogenesis&rft.au=Yun%2C+C%3BWang%2C+Y%3BMukhopadhyay%2C+D%3BDasso%2C+M&rft.aulast=Yun&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Microtubules are Required for Apical Membrane Recycling in Polarized WIF-B9 Cells and Provide the "Missing Link" to the Canalcular Actin Network T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620506; 4740859 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wakabayashi, Y AU - Bourguet-Kondracki, M AU - Lippincott-Schwartz, J AU - Arias, I M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recycling KW - Waste management KW - Membranes KW - Actin KW - Microtubules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Dynamic+Microtubules+are+Required+for+Apical+Membrane+Recycling+in+Polarized+WIF-B9+Cells+and+Provide+the+%22Missing+Link%22+to+the+Canalcular+Actin+Network&rft.au=Wakabayashi%2C+Y%3BBourguet-Kondracki%2C+M%3BLippincott-Schwartz%2C+J%3BArias%2C+I+M&rft.aulast=Wakabayashi&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Cerebellar Stellate and Basket Cells in GAD65-eGFP Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39620389; 4739434 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Davis, M I AU - Hassoun, A T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39620389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Development+of+Cerebellar+Stellate+and+Basket+Cells+in+GAD65-eGFP+Mice&rft.au=Davis%2C+M+I%3BHassoun%2C+A+T&rft.aulast=Davis&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Store-operated TRPC7 Channels Function Independently of Stim1 and Orai1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619944; 4739310 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - DeHaven, W I AU - Bird, G S AU - Putney, J W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium channels KW - Orai1 protein KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Store-operated+TRPC7+Channels+Function+Independently+of+Stim1+and+Orai1&rft.au=DeHaven%2C+W+I%3BBird%2C+G+S%3BPutney%2C+J+W&rft.aulast=DeHaven&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between the Calcium Sensor Stim1 and the Ca Channel Orai1 in Activated Jurkat T Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619869; 4738734 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Barr, V A AU - Bernot, K M AU - Balagopalan, L AU - Srikanth, S AU - Gwack, Y AU - Helman, D J AU - Rao, A AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium channels KW - Sensors KW - Lymphocytes T KW - Orai1 protein KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619869?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Interactions+between+the+Calcium+Sensor+Stim1+and+the+Ca+Channel+Orai1+in+Activated+Jurkat+T+Cells&rft.au=Barr%2C+V+A%3BBernot%2C+K+M%3BBalagopalan%2C+L%3BSrikanth%2C+S%3BGwack%2C+Y%3BHelman%2C+D+J%3BRao%2C+A%3BSamelson%2C+L+E&rft.aulast=Barr&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Maternal Complex Essential for Progression Beyond the Early Cleavage Stage of Mouse Embryogenesis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39619385; 4740188 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Li, L. AU - Baibakokv, B AU - Dean, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Embryogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39619385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Maternal+Complex+Essential+for+Progression+Beyond+the+Early+Cleavage+Stage+of+Mouse+Embryogenesis&rft.au=Li%2C+L.%3BBaibakokv%2C+B%3BDean%2C+J&rft.aulast=Li&rft.aufirst=L.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Inhibitory Peptide (CIP) Specifically Inhibits Cdk5/p25 Activity and Regulates Insulin Secretion in Pancreatic Beta Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39618027; 4738780 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Zheng, Y AU - Hu, Y. AU - Zhang, A AU - Grant, P AU - Notkins, A AU - Pant, H C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Insulin KW - Cyclin-dependent kinase 5 KW - Secretion KW - Pancreas KW - Beta cells KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39618027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cdk5+Inhibitory+Peptide+%28CIP%29+Specifically+Inhibits+Cdk5%2Fp25+Activity+and+Regulates+Insulin+Secretion+in+Pancreatic+Beta+Cells&rft.au=Zheng%2C+Y%3BHu%2C+Y.%3BZhang%2C+A%3BGrant%2C+P%3BNotkins%2C+A%3BPant%2C+H+C&rft.aulast=Zheng&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of the Mechanism of Ash1 mRNA Transport by Myo4p T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39617777; 4739146 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Bond, L M AU - Sellers, J R AU - Bloom, K AU - Sakamoto, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - MRNA KW - RNA transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39617777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Characterization+of+the+Mechanism+of+Ash1+mRNA+Transport+by+Myo4p&rft.au=Bond%2C+L+M%3BSellers%2C+J+R%3BBloom%2C+K%3BSakamoto%2C+T&rft.aulast=Bond&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Small Angle Neutron Scattering (SANS) Studies of Clathrin Triskelia in Solution T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39615866; 4739267 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ferguson, M L AU - Prasad, K AU - Boukari, H AU - Sackett, D L AU - Krueger, S AU - Lafer, E M AU - Nossal, R J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Clathrin KW - Neutron scattering KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Small+Angle+Neutron+Scattering+%28SANS%29+Studies+of+Clathrin+Triskelia+in+Solution&rft.au=Ferguson%2C+M+L%3BPrasad%2C+K%3BBoukari%2C+H%3BSackett%2C+D+L%3BKrueger%2C+S%3BLafer%2C+E+M%3BNossal%2C+R+J&rft.aulast=Ferguson&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lamin A-dependent Misregulation of Adult Stem Cells Associated with Accelerated Aging T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39615601; 4738223 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Scaffidi, P AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Aging KW - Stem cells KW - Lamins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Lamin+A-dependent+Misregulation+of+Adult+Stem+Cells+Associated+with+Accelerated+Aging&rft.au=Scaffidi%2C+P%3BMisteli%2C+T&rft.aulast=Scaffidi&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mucolipin-1 Channel Activity is Regulated by Protein Kinase a Mediated Phosphorylation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612940; 4740142 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Vergarajauregui, S AU - Oberdick, R AU - Kiselyov, K AU - Puertollano, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Channels KW - Protein kinase A KW - Channel gating KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mucolipin-1+Channel+Activity+is+Regulated+by+Protein+Kinase+a+Mediated+Phosphorylation&rft.au=Vergarajauregui%2C+S%3BOberdick%2C+R%3BKiselyov%2C+K%3BPuertollano%2C+R&rft.aulast=Vergarajauregui&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mouse Mammary Microenvironment Redirects Spermatogenic, Neural, and Marrow Cells to a Mammary Epithelial Progenitor Cell Fate T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612777; 4738422 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Boulanger, C A AU - Booth, B W AU - Mack, D L AU - Androutsellis-Theotokis, A AU - Rosu-Myles, M AU - Wolff, L AU - McKay, R AU - Smith, G H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Microenvironments KW - Neural stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Mouse+Mammary+Microenvironment+Redirects+Spermatogenic%2C+Neural%2C+and+Marrow+Cells+to+a+Mammary+Epithelial+Progenitor+Cell+Fate&rft.au=Boulanger%2C+C+A%3BBooth%2C+B+W%3BMack%2C+D+L%3BAndroutsellis-Theotokis%2C+A%3BRosu-Myles%2C+M%3BWolff%2C+L%3BMcKay%2C+R%3BSmith%2C+G+H&rft.aulast=Boulanger&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VEGF Induces Autotaxin Expression in Ovarian Cancer and Endothelial Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612559; 4740023 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ptaszynska, M M AU - Pendrak, M L AU - Roberts, D D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Ovarian cancer KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=VEGF+Induces+Autotaxin+Expression+in+Ovarian+Cancer+and+Endothelial+Cells&rft.au=Ptaszynska%2C+M+M%3BPendrak%2C+M+L%3BRoberts%2C+D+D&rft.aulast=Ptaszynska&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Concurrent Fast and Slow Cycling of a Transcriptional Activator at an Endogenous Promoter T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39612011; 4738338 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Karpova, T S AU - Kim, M J AU - Spriet, C AU - Nalley, K AU - Stasevich, T AU - Kherrouche, Z AU - Heliot, L AU - McNally, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Promoters KW - Transcription KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612011?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Concurrent+Fast+and+Slow+Cycling+of+a+Transcriptional+Activator+at+an+Endogenous+Promoter&rft.au=Karpova%2C+T+S%3BKim%2C+M+J%3BSpriet%2C+C%3BNalley%2C+K%3BStasevich%2C+T%3BKherrouche%2C+Z%3BHeliot%2C+L%3BMcNally%2C+J+G&rft.aulast=Karpova&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - VEGF Controls Endothelial Cell Permeability by the Endocytosis of VE-cadherin T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611411; 4738249 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gavard, J AU - Gutkind, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Permeability KW - Endocytosis KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=VEGF+Controls+Endothelial+Cell+Permeability+by+the+Endocytosis+of+VE-cadherin&rft.au=Gavard%2C+J%3BGutkind%2C+J&rft.aulast=Gavard&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MT2-MMP Regulates Epithelial Morphogenesis and Collagen-IV Expression during Mouse Submandibular Gland Development T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611367; 4738562 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rebustini, I T AU - Myers, C AU - Surmak, A AU - Szabova, L AU - Lassiter, K AU - Holmbeck, K AU - Hoffman, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Collagen KW - Submandibular gland KW - Morphogenesis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=MT2-MMP+Regulates+Epithelial+Morphogenesis+and+Collagen-IV+Expression+during+Mouse+Submandibular+Gland+Development&rft.au=Rebustini%2C+I+T%3BMyers%2C+C%3BSurmak%2C+A%3BSzabova%2C+L%3BLassiter%2C+K%3BHolmbeck%2C+K%3BHoffman%2C+M&rft.aulast=Rebustini&rft.aufirst=I&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endocytosis of Fluorescent Probes in the Submandibular Salivary Glands of Living Rodents: An Intra-vital Two-Photon Microscopy Study T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39611072; 4738479 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Masedunskas, A AU - Weigert, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Microscopy KW - Rodents KW - Fluorescent indicators KW - Salivary gland KW - Endocytosis KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39611072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Endocytosis+of+Fluorescent+Probes+in+the+Submandibular+Salivary+Glands+of+Living+Rodents%3A+An+Intra-vital+Two-Photon+Microscopy+Study&rft.au=Masedunskas%2C+A%3BWeigert%2C+R&rft.aulast=Masedunskas&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Quantitative Scheme to Estimate Proliferation, Differentiation, and Dedifferentiation for Embryonic Stem Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39610744; 4738403 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Huang, W AU - Raaka, B M AU - Chow, C C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Cell proliferation KW - Differentiation KW - Embryo cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39610744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Quantitative+Scheme+to+Estimate+Proliferation%2C+Differentiation%2C+and+Dedifferentiation+for+Embryonic+Stem+Cells&rft.au=Huang%2C+W%3BRaaka%2C+B+M%3BChow%2C+C+C&rft.aulast=Huang&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR2 Stimulation Enhances Activation of NADPH Oxidase p47 super(phox-/-)-deficient CD8 T Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39609817; 4738736 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wanga, J A AU - Donaldson, M AU - Wood, A AU - Jackson, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - NAD(P)H oxidase KW - TLR2 protein KW - CD8 antigen KW - Lymphocytes T KW - Cell activation KW - Toll-like receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=TLR2+Stimulation+Enhances+Activation+of+NADPH+Oxidase+p47+super%28phox-%2F-%29-deficient+CD8+T+Cells&rft.au=Wanga%2C+J+A%3BDonaldson%2C+M%3BWood%2C+A%3BJackson%2C+S&rft.aulast=Wanga&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Analyses of Stream Formation during Dictyostelium Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39609166; 4738595 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - McCann, C P AU - Kriebel, P W AU - Rericha, E C AU - Parent, C A AU - Losert, W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Streams KW - Chemotaxis KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Quantitative+Analyses+of+Stream+Formation+during+Dictyostelium+Chemotaxis&rft.au=McCann%2C+C+P%3BKriebel%2C+P+W%3BRericha%2C+E+C%3BParent%2C+C+A%3BLosert%2C+W&rft.aulast=McCann&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Kelch-related Protein Krp1 is Required for Mature Myofibril Accumulation in Cultured Mouse Cardiomyocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39608826; 4738913 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Greenberg, C C AU - Connelly, P S AU - Daniels, M P AU - Horowits, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cardiomyocytes KW - Kelch-related protein KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39608826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Kelch-related+Protein+Krp1+is+Required+for+Mature+Myofibril+Accumulation+in+Cultured+Mouse+Cardiomyocytes&rft.au=Greenberg%2C+C+C%3BConnelly%2C+P+S%3BDaniels%2C+M+P%3BHorowits%2C+R&rft.aulast=Greenberg&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syntabulin-KIF5B-mediated Axonal Transport Contributes to Activity-dependent Presynaptic Assembly T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39605350; 4739449 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Cai, Q AU - Pan, P AU - Sheng, Z Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Axonal transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Syntabulin-KIF5B-mediated+Axonal+Transport+Contributes+to+Activity-dependent+Presynaptic+Assembly&rft.au=Cai%2C+Q%3BPan%2C+P%3BSheng%2C+Z&rft.aulast=Cai&rft.aufirst=Q&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maturation and Targeting of Extracellular Hydrogen Peroxide Generators, Duox1 and Duox2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39604603; 4740312 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Morand, S C AU - Leto, T L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Hydrogen peroxide KW - Sexual maturity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Maturation+and+Targeting+of+Extracellular+Hydrogen+Peroxide+Generators%2C+Duox1+and+Duox2&rft.au=Morand%2C+S+C%3BLeto%2C+T+L&rft.aulast=Morand&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acanthamoeba Myosin IC and PIP2 Colocalize In Vivo T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39602647; 4739860 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Brzeska, H AU - Korn, E D Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Phosphatidylinositol 4,5-diphosphate KW - Acanthamoeba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Use+of+mental+health+services+for+anxiety%2C+mood%2C+and+substance+disorders+in+17+countries+in+the+WHO+world+mental+health+surveys.&rft.au=Wang%2C+Philip+S%3BAguilar-Gaxiola%2C+Sergio%3BAlonso%2C+Jordi%3BAngermeyer%2C+Matthias+C%3BBorges%2C+Guilherme%3BBromet%2C+Evelyn+J%3BBruffaerts%2C+Ronny%3Bde+Girolamo%2C+Giovanni%3Bde+Graaf%2C+Ron%3BGureje%2C+Oye%3BHaro%2C+Josep+Maria%3BKaram%2C+Elie+G%3BKessler%2C+Ronald+C%3BKovess%2C+Viviane%3BLane%2C+Michael+C%3BLee%2C+Sing%3BLevinson%2C+Daphna%3BOno%2C+Yutaka%3BPetukhova%2C+Maria%3BPosada-Villa%2C+Jos%C3%A9%3BSeedat%2C+Soraya%3BWells%2C+J+Elisabeth&rft.aulast=Wang&rft.aufirst=Philip&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Damage is not Required for the Action of DNA Damage Response Pathways T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39602575; 4739825 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Soutoglou, E AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=DNA+Damage+is+not+Required+for+the+Action+of+DNA+Damage+Response+Pathways&rft.au=Soutoglou%2C+E%3BMisteli%2C+T&rft.aulast=Soutoglou&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutive Trafficking of G-Protein Coupled Receptors T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39597078; 4738469 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Scarselli, M AU - Donaldson, J G Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - G protein-coupled receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39597078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Constitutive+Trafficking+of+G-Protein+Coupled+Receptors&rft.au=Scarselli%2C+M%3BDonaldson%2C+J+G&rft.aulast=Scarselli&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p47phox-deficient Dendritic Cells Enhance Antigen-specific T Cell Proliferation and IFN-g Secretion T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39593236; 4740007 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Jendrysik, M A AU - Zhu, N AU - Wood, A AU - Changpriroa, C AU - Jackson, S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell proliferation KW - G-Interferon KW - Dendritic cells KW - Lymphocytes T KW - Secretion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=p47phox-deficient+Dendritic+Cells+Enhance+Antigen-specific+T+Cell+Proliferation+and+IFN-g+Secretion&rft.au=Jendrysik%2C+M+A%3BZhu%2C+N%3BWood%2C+A%3BChangpriroa%2C+C%3BJackson%2C+S&rft.aulast=Jendrysik&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Molecular Mechanism for Aging-related Loss of Heterochromatin and DNA Damage T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39592393; 4740568 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Pegoraro, G AU - Misteli, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Heterochromatin KW - Molecular modelling KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39592393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Molecular+Mechanism+for+Aging-related+Loss+of+Heterochromatin+and+DNA+Damage&rft.au=Pegoraro%2C+G%3BMisteli%2C+T&rft.aulast=Pegoraro&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Search of ECM: Live-Cell Imaging of Micro-patterned Substrata T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39590744; 4739580 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Doyle, A D AU - Wang, F W AU - Yamada, K M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Imaging techniques KW - Extracellular matrix KW - Substrata KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39590744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=In+Search+of+ECM%3A+Live-Cell+Imaging+of+Micro-patterned+Substrata&rft.au=Doyle%2C+A+D%3BWang%2C+F+W%3BYamada%2C+K+M&rft.aulast=Doyle&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Protein+Discovery+and+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Extensibility of Coiled-Coil Regions of Processive and Nonprocessive Myosin V Molecules T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39589394; 4739144 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Nagy, A AU - Sellers, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39589394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Extensibility+of+Coiled-Coil+Regions+of+Processive+and+Nonprocessive+Myosin+V+Molecules&rft.au=Nagy%2C+A%3BSellers%2C+J&rft.aulast=Nagy&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of O-GlcNAcase on Insulin Signaling in Adipocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39588727; 4739038 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Keembiyehetty, C N AU - Kim, E J AU - Love, D C AU - Hanover, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Insulin KW - Signal transduction KW - Adipocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39588727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Effects+of+O-GlcNAcase+on+Insulin+Signaling+in+Adipocytes&rft.au=Keembiyehetty%2C+C+N%3BKim%2C+E+J%3BLove%2C+D+C%3BHanover%2C+J&rft.aulast=Keembiyehetty&rft.aufirst=C&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nuclear Envelope Assembly by Fusion between Nuclear Membrane Vesicles and Protein-free Liposomes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39587626; 4740895 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rafikova, E AU - Ramos, C AU - Melikov, K AU - Dye, L AU - Chernomordik, L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39587626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Nuclear+Envelope+Assembly+by+Fusion+between+Nuclear+Membrane+Vesicles+and+Protein-free+Liposomes&rft.au=Rafikova%2C+E%3BRamos%2C+C%3BMelikov%2C+K%3BDye%2C+L%3BChernomordik%2C+L&rft.aulast=Rafikova&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Pseudomonas aeruginosa Pigment Pyocyanin Inhibits the Dual Oxidase-mediated Antimicrobial Defense System in Human Airways T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39586422; 4739503 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rada, B AU - Lekstrom, K AU - Leto, T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Pigments KW - Antimicrobial agents KW - Pyocyanin KW - Respiratory tract KW - Pseudomonas aeruginosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39586422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Pseudomonas+aeruginosa+Pigment+Pyocyanin+Inhibits+the+Dual+Oxidase-mediated+Antimicrobial+Defense+System+in+Human+Airways&rft.au=Rada%2C+B%3BLekstrom%2C+K%3BLeto%2C+T&rft.aulast=Rada&rft.aufirst=B&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PGC1a Induces Chromatin Structure Changes at the MHRE Region of the ERRa Gene T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39585444; 4739413 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Wang, L AU - Hu, P. AU - Teng, C T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39585444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=PGC1a+Induces+Chromatin+Structure+Changes+at+the+MHRE+Region+of+the+ERRa+Gene&rft.au=Wang%2C+L%3BHu%2C+P.%3BTeng%2C+C+T&rft.aulast=Wang&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The High Mobility Group Box Transcription Factor Nhp6Ap Enters the Nucleus by a Calmodulin-dependent, Ran-independent Pathway T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39585304; 4740137 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Hanover, J AU - O'Kane, M AU - Love, D AU - Yen, Y AU - Johnson, R AU - Prinz, W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mobility KW - Nuclei KW - High mobility group proteins KW - Transcription factors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39585304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+High+Mobility+Group+Box+Transcription+Factor+Nhp6Ap+Enters+the+Nucleus+by+a+Calmodulin-dependent%2C+Ran-independent+Pathway&rft.au=Hanover%2C+J%3BO%27Kane%2C+M%3BLove%2C+D%3BYen%2C+Y%3BJohnson%2C+R%3BPrinz%2C+W&rft.aulast=Hanover&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Point Mutation in Nonmuscle Myosin II-C is Associated with a Novel Lymphoproliferative Disease T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39584178; 4740470 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kim, K Y AU - Shin, D AU - Morse, H C AU - Snow, A AU - Lenardo, M J AU - Hwang, I Y AU - Park, C AU - Kehrl, J H AU - Brinster, L R AU - Zerfas, P AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Point mutation KW - Immunoproliferative diseases KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Point+Mutation+in+Nonmuscle+Myosin+II-C+is+Associated+with+a+Novel+Lymphoproliferative+Disease&rft.au=Kim%2C+K+Y%3BShin%2C+D%3BMorse%2C+H+C%3BSnow%2C+A%3BLenardo%2C+M+J%3BHwang%2C+I+Y%3BPark%2C+C%3BKehrl%2C+J+H%3BBrinster%2C+L+R%3BZerfas%2C+P%3BAdelstein%2C+R+S&rft.aulast=Kim&rft.aufirst=K&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carboxypeptidase E Recruits Microtubule Motors to Peptidergic Vesicles for Post-Golgi Trafficking to the Release Site T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583912; 4740244 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Park, J J AU - Loh, Y Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recruitment KW - Microtubules KW - Vesicles KW - Carboxypeptidase E KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Carboxypeptidase+E+Recruits+Microtubule+Motors+to+Peptidergic+Vesicles+for+Post-Golgi+Trafficking+to+the+Release+Site&rft.au=Park%2C+J+J%3BLoh%2C+Y&rft.aulast=Park&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chromatin Reorganization in Response to Migration Cues T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583758; 4740430 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gerlitz, G AU - Livnat, I AU - Ziv, C AU - Yarden, O AU - Reiner, O AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Migration KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Chromatin+Reorganization+in+Response+to+Migration+Cues&rft.au=Gerlitz%2C+G%3BLivnat%2C+I%3BZiv%2C+C%3BYarden%2C+O%3BReiner%2C+O%3BBustin%2C+M&rft.aulast=Gerlitz&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mast Cells Possess Distinct Secretory Granule Subsets Whose Exocytosis is Regulated by Different SNARE Isoforms T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583591; 4740831 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Puri, N AU - Roche, P A Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mast cells KW - SNAP receptors KW - Exocytosis KW - Secretory vesicles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Mast+Cells+Possess+Distinct+Secretory+Granule+Subsets+Whose+Exocytosis+is+Regulated+by+Different+SNARE+Isoforms&rft.au=Puri%2C+N%3BRoche%2C+P+A&rft.aulast=Puri&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Nonmuscle Myosin II in Mouse Heart Development T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39583392; 4740475 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Ma, X. AU - Adelstein, R S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Role+of+Nonmuscle+Myosin+II+in+Mouse+Heart+Development&rft.au=Ma%2C+X.%3BAdelstein%2C+R+S&rft.aulast=Ma&rft.aufirst=X.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cbl-dependent Regulation of LAT-nucleated Signaling Complexes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582675; 4738737 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Balagopalan, L AU - Barr, V A AU - Sommers, C L AU - Barda-Saad, M AU - Goyal, A AU - Isakowitz, M E AU - Samelson, L E Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cbl-dependent+Regulation+of+LAT-nucleated+Signaling+Complexes&rft.au=Balagopalan%2C+L%3BBarr%2C+V+A%3BSommers%2C+C+L%3BBarda-Saad%2C+M%3BGoyal%2C+A%3BIsakowitz%2C+M+E%3BSamelson%2C+L+E&rft.aulast=Balagopalan&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiogenesis Inhibition by Semaphorin 3E T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39582404; 4740070 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Sakurai, A AU - Gavard, J AU - Basile, J R AU - Annas-Linhares, Y AU - Gutkind, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Semaphorins KW - Angiogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Angiogenesis+Inhibition+by+Semaphorin+3E&rft.au=Sakurai%2C+A%3BGavard%2C+J%3BBasile%2C+J+R%3BAnnas-Linhares%2C+Y%3BGutkind%2C+J&rft.aulast=Sakurai&rft.aufirst=A&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SZY-20, a Novel RNA-Binding Protein, Limits Centrosome Size T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39581400; 4738800 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Song, M AU - Iyer, A AU - O'Connell, K F Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - RNA-binding protein KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=SZY-20%2C+a+Novel+RNA-Binding+Protein%2C+Limits+Centrosome+Size&rft.au=Song%2C+M%3BIyer%2C+A%3BO%27Connell%2C+K+F&rft.aulast=Song&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of RNA Polymerase I Transcription in Response to DNA Breaks is ATM-dependent T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39580737; 4738302 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Kruhlak, M AU - Crouch, E AU - Orlov, M AU - Montano, C AU - Gorski, S AU - Nussenzweig, A AU - Misteli, T AU - Robert, P AU - Casellas, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Transcription KW - DNA-directed RNA polymerase KW - DNA damage KW - Nucleic acids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Inhibition+of+RNA+Polymerase+I+Transcription+in+Response+to+DNA+Breaks+is+ATM-dependent&rft.au=Kruhlak%2C+M%3BCrouch%2C+E%3BOrlov%2C+M%3BMontano%2C+C%3BGorski%2C+S%3BNussenzweig%2C+A%3BMisteli%2C+T%3BRobert%2C+P%3BCasellas%2C+R&rft.aulast=Kruhlak&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proper Expression of Epidermal Stratification Markers Requires Down-regulation of High Mobility Group Nucleosome (HMGN) Proteins Expression T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39580525; 4738256 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Furusawa, T AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stratification KW - Mobility KW - Nucleosomes KW - High mobility group proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Proper+Expression+of+Epidermal+Stratification+Markers+Requires+Down-regulation+of+High+Mobility+Group+Nucleosome+%28HMGN%29+Proteins+Expression&rft.au=Furusawa%2C+T%3BBustin%2C+M&rft.aulast=Furusawa&rft.aufirst=T&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Connexin43 Modulates Polarized Cell Morphology and Directional Cell Migration through Tubulin Interaction and the Assembly of Stabilized Microtubules T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39579788; 4739302 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Francis, R J B AU - Xu, X. AU - Park, K AU - Wei, C AU - Chang, S AU - Alaei, S AU - Charterjee, B AU - Bulinsky, C AU - Lo, C W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell morphology KW - Tubulin KW - Connexin 43 KW - Microtubules KW - Cell migration KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Connexin43+Modulates+Polarized+Cell+Morphology+and+Directional+Cell+Migration+through+Tubulin+Interaction+and+the+Assembly+of+Stabilized+Microtubules&rft.au=Francis%2C+R+J+B%3BXu%2C+X.%3BPark%2C+K%3BWei%2C+C%3BChang%2C+S%3BAlaei%2C+S%3BCharterjee%2C+B%3BBulinsky%2C+C%3BLo%2C+C+W&rft.aulast=Francis&rft.aufirst=R+J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Diaspartate Motif is Required for Direct Binding of HIV Nef to the Clathrin Adaptor Complex AP2 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39579573; 4739269 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lindwasser, W AU - Smith, W J AU - Chaudhuri, R AU - Yang, P AU - Hurley, J H AU - Bonifacino, J S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Human immunodeficiency virus KW - Clathrin KW - Nef protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=A+Diaspartate+Motif+is+Required+for+Direct+Binding+of+HIV+Nef+to+the+Clathrin+Adaptor+Complex+AP2&rft.au=Lindwasser%2C+W%3BSmith%2C+W+J%3BChaudhuri%2C+R%3BYang%2C+P%3BHurley%2C+J+H%3BBonifacino%2C+J+S&rft.aulast=Lindwasser&rft.aufirst=W&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apq12p: A Novel Cell Cycle Regulator in Saccharomyces cerevisiae T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39578262; 4738804 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fearon, P AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cell cycle KW - Saccharomyces cerevisiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Apq12p%3A+A+Novel+Cell+Cycle+Regulator+in+Saccharomyces+cerevisiae&rft.au=Fearon%2C+P%3BCohen-Fix%2C+O&rft.aulast=Fearon&rft.aufirst=P&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Identification of Esp1p Regulators Using a Suppressor Screen T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39578226; 4738798 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Barbour, L AU - Cohen-Fix, O Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39578226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+Identification+of+Esp1p+Regulators+Using+a+Suppressor+Screen&rft.au=Barbour%2C+L%3BCohen-Fix%2C+O&rft.aulast=Barbour&rft.aufirst=L&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Branching Morphogenesis of Endothelial Cells is Regulated by Myosin Contractility T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39577693; 4738556 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Fischer, R S AU - Gardel, M AU - Waterman, C Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Myosin KW - Endothelial cells KW - Contractility KW - Morphogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Branching+Morphogenesis+of+Endothelial+Cells+is+Regulated+by+Myosin+Contractility&rft.au=Fischer%2C+R+S%3BGardel%2C+M%3BWaterman%2C+C&rft.aulast=Fischer&rft.aufirst=R&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multiple b1 Integrin Cytoplasmic Domain Single Site Mutations Modulate Fibronectin Fibrillogenesis and Integrin Function T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39574434; 4739962 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Green, J A AU - Berrier, A AU - Pankov, R AU - Yamada, K M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mutation KW - Integrins KW - Fibrillogenesis KW - Fibronectin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39574434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Multiple+b1+Integrin+Cytoplasmic+Domain+Single+Site+Mutations+Modulate+Fibronectin+Fibrillogenesis+and+Integrin+Function&rft.au=Green%2C+J+A%3BBerrier%2C+A%3BPankov%2C+R%3BYamada%2C+K+M&rft.aulast=Green&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired Embryonic Stem Cell Differentiation by Aberrant Expression of the Nucleosome Binding Protein HMGN1 T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39569131; 4738412 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Cherukuri, S AU - Rand, E AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Nucleosomes KW - Differentiation KW - Embryo cells KW - Cell differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39569131?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Impaired+Embryonic+Stem+Cell+Differentiation+by+Aberrant+Expression+of+the+Nucleosome+Binding+Protein+HMGN1&rft.au=Cherukuri%2C+S%3BRand%2C+E%3BBustin%2C+M&rft.aulast=Cherukuri&rft.aufirst=S&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Regulation of Centriole Replication in C. elegans T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39538182; 4740749 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Peters, N Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Replication KW - Centrioles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39538182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Developmental+Regulation+of+Centriole+Replication+in+C.+elegans&rft.au=Peters%2C+N&rft.aulast=Peters&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Opposing Roles for Gab2 and Gab3 in M-CSF-mediated Chemotaxis T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39537595; 4740615 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Vedham, V AU - Hall, A B AU - Brugge, J S AU - Coggeshall, K Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Opposing+Roles+for+Gab2+and+Gab3+in+M-CSF-mediated+Chemotaxis&rft.au=Vedham%2C+V%3BHall%2C+A+B%3BBrugge%2C+J+S%3BCoggeshall%2C+K&rft.aulast=Vedham&rft.aufirst=V&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NSBP1: A Novel Protein Which Binds Specifically to Nucleosome in Euchromatin and Affects Cellular Differentiation T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39537477; 4740571 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rochman, M AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Euchromatin KW - Nucleosomes KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=NSBP1%3A+A+Novel+Protein+Which+Binds+Specifically+to+Nucleosome+in+Euchromatin+and+Affects+Cellular+Differentiation&rft.au=Rochman%2C+M%3BBustin%2C+M&rft.aulast=Rochman&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Nonmuscle Myosin IIB and N-RAP in Regulation of Cell Spreading and Myofibril Assembly in Primary Mouse Cardiomyocytes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39535739; 4738912 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Lu, S. AU - Horowits, R Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cardiomyocytes KW - Myosin KW - Myofibrils KW - Cell spreading KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39535739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Role+of+Nonmuscle+Myosin+IIB+and+N-RAP+in+Regulation+of+Cell+Spreading+and+Myofibril+Assembly+in+Primary+Mouse+Cardiomyocytes&rft.au=Lu%2C+S.%3BHorowits%2C+R&rft.aulast=Lu&rft.aufirst=S.&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cleavage Status of ZP2 Determines Initial Sperm-Egg Recognition in Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39534632; 4740898 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Gahlay, G K AU - Dean, J Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Cleavage+Status+of+ZP2+Determines+Initial+Sperm-Egg+Recognition+in+Mice&rft.au=Gahlay%2C+G+K%3BDean%2C+J&rft.aulast=Gahlay&rft.aufirst=G&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of Intracellular Phosphatidylserine in Living Cells T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39534552; 4740830 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Calderon, F AU - Kim, H Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Phosphatidylserine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39534552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Detection+of+Intracellular+Phosphatidylserine+in+Living+Cells&rft.au=Calderon%2C+F%3BKim%2C+H&rft.aulast=Calderon&rft.aufirst=F&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ML-9 Inhibits Store-operated Calcium Entry by Reversing Store Depletion-induced Stim1 Rearrangement T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39533952; 4739309 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Smyth, J T AU - DeHaven, W I AU - Bird, G S AU - Putney, J W Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Calcium KW - STIM1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=ML-9+Inhibits+Store-operated+Calcium+Entry+by+Reversing+Store+Depletion-induced+Stim1+Rearrangement&rft.au=Smyth%2C+J+T%3BDeHaven%2C+W+I%3BBird%2C+G+S%3BPutney%2C+J+W&rft.aulast=Smyth&rft.aufirst=J&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of GAK (auxilin-2) in Developing and Mature Mice T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39533848; 4739279 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Yim, Y AU - Lee, D AU - Eisenberg, E AU - Greene, L Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Essential+Role+of+GAK+%28auxilin-2%29+in+Developing+and+Mature+Mice&rft.au=Yim%2C+Y%3BLee%2C+D%3BEisenberg%2C+E%3BGreene%2C+L&rft.aulast=Yim&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Keeps the Yeast Nucleus Hanging Round?: Methods to Identify Genes that Maintain Nuclear Structure in S. cerevisiae T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39532668; 4739420 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Webster, M T Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39532668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=What+Keeps+the+Yeast+Nucleus+Hanging+Round%3F%3A+Methods+to+Identify+Genes+that+Maintain+Nuclear+Structure+in+S.+cerevisiae&rft.au=Webster%2C+M+T&rft.aulast=Webster&rft.aufirst=M&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Embryonic Stem Cell DNA Methylation Modulates the Interaction of Nucleosome-binding Proteins with Chromatin T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39532555; 4739407 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Rand, E AU - Meshorer, E AU - Bustin, M Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Stem cells KW - Chromatin KW - DNA methylation KW - Embryo cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39532555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Embryonic+Stem+Cell+DNA+Methylation+Modulates+the+Interaction+of+Nucleosome-binding+Proteins+with+Chromatin&rft.au=Rand%2C+E%3BMeshorer%2C+E%3BBustin%2C+M&rft.aulast=Rand&rft.aufirst=E&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Transmembrane Protein, CBP, Responsible for Transiently Anchoring Small Clusters of Thy-1, a GPI-anchored Protein, to the Cytoskeleton T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39531707; 4740238 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Chen, Y AU - Benistant, C AU - Jacobsona, K Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Cytoskeleton KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=Identification+of+a+Transmembrane+Protein%2C+CBP%2C+Responsible+for+Transiently+Anchoring+Small+Clusters+of+Thy-1%2C+a+GPI-anchored+Protein%2C+to+the+Cytoskeleton&rft.au=Chen%2C+Y%3BBenistant%2C+C%3BJacobsona%2C+K&rft.aulast=Chen&rft.aufirst=Y&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The C-terminal Extension of hCenexin1 Is Critical for Proper Recruitment and Mitotic Functions of Mammalian Polo-like Kinase 1 (Plk1) at the Centrosomes T2 - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AN - 39528343; 4738201 JF - 47th Annual Meeting of the American Society for Cell Biology (ASCB 2007) AU - Soung, N AU - Yu, L. AU - Veenstra, T AU - Lee, K S Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 KW - Recruitment KW - Polo-like kinase 1 KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39528343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.atitle=The+C-terminal+Extension+of+hCenexin1+Is+Critical+for+Proper+Recruitment+and+Mitotic+Functions+of+Mammalian+Polo-like+Kinase+1+%28Plk1%29+at+the+Centrosomes&rft.au=Soung%2C+N%3BYu%2C+L.%3BVeenstra%2C+T%3BLee%2C+K+S&rft.aulast=Soung&rft.aufirst=N&rft.date=2007-12-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Meeting+of+the+American+Society+for+Cell+Biology+%28ASCB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/index.cfm?ID=103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Empirical likelihood-based inference for genetic mixture models AN - 36978225; 3774857 JF - Canadian journal of statistics AU - Huang, Chiung-Yu AU - Qin, Jing AU - Zou, Fei AD - US National Institutes of Health, Bethesda ; University of North Carolina Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 563 EP - 574 VL - 35 IS - 4 SN - 0319-5724, 0319-5724 KW - Economics KW - Statistical models KW - Significance tests KW - Estimation KW - Statistical methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36978225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Canadian+journal+of+statistics&rft.atitle=Empirical+likelihood-based+inference+for+genetic+mixture+models&rft.au=Huang%2C+Chiung-Yu%3BQin%2C+Jing%3BZou%2C+Fei&rft.aulast=Huang&rft.aufirst=Chiung-Yu&rft.date=2007-12-01&rft.volume=35&rft.issue=4&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Canadian+journal+of+statistics&rft.issn=03195724&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 4403 7854; 11658 12224 971 ER - TY - JOUR T1 - Physicians' access to ethics support services in four European countries AN - 36923805; 3565291 AB - Clinical ethics support services are developing in Europe. They will be most useful if they are designed to match the ethical concern of clinicians. We conducted a cross-sectional mailed survey on random samples of general physicians in Norway, Switzerland, Italy, and the UK, to assess their access to different types of ethics support services, and to describe what makes them more likely to have used available ethics support. Respondents reported access to formal ethics support services such as clinical ethics committees (23%), consultation in individual cases (17.6%), and individual ethicists (8.8%), but also to other kinds of less formal ethics support (23.6%). Access to formal ethics support services was associated with work in urban hospitals. Informal ethics resources were more evenly distributed. Although most respondents (81%) reported that they would find help useful in Reprinted by permission of Springer JF - Health care analysis AU - Hurst, Samia A AU - Reiter-Theil, Stella AU - Perrier, Arnaud AU - Forde, Reidun AU - Slowther, Anne-Marie AU - Pegoraro, Renzo AU - Danis, Marion AD - Université de Genève ; Universität Basel ; Hôpitaux Universitaires de Genève ; Norwegian Medical Association ; University of Oxford ; Fondazione Lanza, Padova ; National Institutes of Health, Bethesda Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 321 EP - 335 VL - 15 IS - 4 SN - 1065-3058, 1065-3058 KW - Political Science KW - Sociology KW - Access to services KW - Comparative analysis KW - Social support KW - Doctors KW - Survey data KW - Medical ethics KW - Hospital services KW - Norway KW - Italy KW - Switzerland KW - United Kingdom KW - Cross-national analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36923805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+care+analysis&rft.atitle=Physicians%27+access+to+ethics+support+services+in+four+European+countries&rft.au=Hurst%2C+Samia+A%3BReiter-Theil%2C+Stella%3BPerrier%2C+Arnaud%3BForde%2C+Reidun%3BSlowther%2C+Anne-Marie%3BPegoraro%2C+Renzo%3BDanis%2C+Marion&rft.aulast=Hurst&rft.aufirst=Samia&rft.date=2007-12-01&rft.volume=15&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Health+care+analysis&rft.issn=10653058&rft_id=info:doi/10.1007%2Fs10728-007-0072-6 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3675 10299 13682 7883 8864; 7879 4408 8282 8281 6085; 3060 971; 11938 11949 13521; 12427 12429; 6008 5792 10484; 2630 971; 438 462 129 302; 306 302 129 370; 408 462 129; 188 396 129 DO - http://dx.doi.org/10.1007/s10728-007-0072-6 ER - TY - JOUR T1 - Self-administration of drugs in animals and humans as a model and an investigative tool AN - 36826737; 3516019 AB - Aims To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self-administration in animals and humans. Background The use of drug self-administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self-administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre-clinical research that also involves screening with a variety of simpler behavioral techniques, drug self-administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self-administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self-administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Panlilio, Leigh V AU - Goldberg, Steven R AD - US National Institute on Drug Abuse Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1863 EP - 1870 VL - 102 IS - 12 SN - 0965-2140, 0965-2140 KW - Sociology KW - Medical research KW - Drug abuse KW - Self-management UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36826737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Self-administration+of+drugs+in+animals+and+humans+as+a+model+and+an+investigative+tool&rft.au=Panlilio%2C+Leigh+V%3BGoldberg%2C+Steven+R&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-12-01&rft.volume=102&rft.issue=12&rft.spage=1863&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02011.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7886 10902; 3742 1121 11776 3753 3755; 11480 7625 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02011.x ER - TY - JOUR T1 - Incorporating historical control data when comparing tumor incidence rates AN - 36819949; 3510623 JF - Journal of the American Statistical Association AU - Peddada, Shyamal D AU - Dinse, Gregg E AU - Kissling, Grace E AD - National Institute of Environmental Health Sciences Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1212 EP - 1220 VL - 102 IS - 480 SN - 0162-1459, 0162-1459 KW - Anthropology KW - Medical care KW - Statistical analysis KW - Survival KW - Toxicity KW - Statistical methods KW - Cancer KW - Bayesian method KW - Methodology KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36819949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Incorporating+historical+control+data+when+comparing+tumor+incidence+rates&rft.au=Peddada%2C+Shyamal+D%3BDinse%2C+Gregg+E%3BKissling%2C+Grace+E&rft.aulast=Peddada&rft.aufirst=Shyamal&rft.date=2007-12-01&rft.volume=102&rft.issue=480&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214506000001356 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 1939 3617 6220; 7875 5775 13521; 10449 5772; 12430; 7994; 12807 9818; 1512 3865 4025 DO - http://dx.doi.org/10.1198/016214506000001356 ER - TY - JOUR T1 - New directions in race research AN - 36816697; 3510923 JF - Social forces AU - Lee, Jennifer AU - Bean, Frank D AU - Hitlin, Steven AU - Brown, J Scott AU - Elder Jr, Glen H AU - Croll, Paul R AU - Hochschild, Jennifer L AU - Weaver, Vesla AU - Bond, Carolyn AU - Williams, Richard AU - Krysan, Maria AU - Bader, Michael AU - Marsh, Kris AU - Darity, Jr., William A. AU - Cohen, Philip N AU - Casper, Lynne M AU - Salters, Danielle AU - Sarkisian, Natalia AU - Phillips, Elizabeth M AU - Odunlami, Adebola O AU - Bonham, Vence L AU - Bratter, Jenifer AD - University of California, Irvine ; University of Iowa ; Miami University ; University of North Carolina, Chapel Hill ; University of Minnesota ; Harvard University ; University of Virginia ; West Chester University ; University of Notre Dame ; University of Illinois, Chicago ; University of Michigan ; Duke University ; University of Southern California ; Boston College ; National Human Genome Research Institute ; Rice University Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 553 EP - 850 VL - 86 IS - 2 SN - 0037-7732, 0037-7732 KW - Sociology KW - Detroit KW - Masculinity KW - Multiculturalism KW - Socioeconomic status KW - Blacks KW - Parent-child relations KW - Urban sociology KW - Social change KW - Self KW - Property KW - Social norms KW - Race relations KW - Genetics KW - Cities KW - Colour KW - Classification KW - Diseases KW - Community KW - Social psychology KW - Immigration KW - Identity politics KW - Ethnicity KW - Social systems KW - Organization theory KW - Discrimination KW - Marriage KW - U.S.A. KW - Children KW - Professionalization KW - Social inequality KW - Identity KW - Social values KW - African-Americans UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+forces&rft.atitle=New+directions+in+race+research&rft.au=Lee%2C+Jennifer%3BBean%2C+Frank+D%3BHitlin%2C+Steven%3BBrown%2C+J+Scott%3BElder+Jr%2C+Glen+H%3BCroll%2C+Paul+R%3BHochschild%2C+Jennifer+L%3BWeaver%2C+Vesla%3BBond%2C+Carolyn%3BWilliams%2C+Richard%3BKrysan%2C+Maria%3BBader%2C+Michael%3BMarsh%2C+Kris%3BDarity%2C+Jr.%2C+William+A.%3BCohen%2C+Philip+N%3BCasper%2C+Lynne+M%3BSalters%2C+Danielle%3BSarkisian%2C+Natalia%3BPhillips%2C+Elizabeth+M%3BOdunlami%2C+Adebola+O%3BBonham%2C+Vence+L%3BBratter%2C+Jenifer&rft.aulast=Lee&rft.aufirst=Jennifer&rft.date=2007-12-01&rft.volume=86&rft.issue=2&rft.spage=553&rft.isbn=&rft.btitle=&rft.title=Social+forces&rft.issn=00377732&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 10 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10558 6093; 4435; 11442 6191; 6191; 6233 8040; 11783; 2360 2688 2449 10404; 6197 9809; 11901 10404; 11942; 11875 11979; 11948 13245 8281 6085; 2509 13338 3198; 3612 3549 2688 2449 10404; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 10339; 11853 6489; 13194 12008; 2603; 635 1656 10555 6091 961 636 4424; 2274 13161 1247; 1656 10555 6091; 7748 6823; 10301; 7782 5421 6091; 9012; 3617 6220; 5460 1615 8573 11325; 2212; 8346 3127 3121 3198 3549 2688 2449 10404; 9178 4777 6093 6823; 433 293 14 ER - TY - JOUR T1 - Bayesian multivariate isotonic regression splines: applications to carcinogenicity studies AN - 36816256; 3510619 JF - Journal of the American Statistical Association AU - Cai, Bo AU - Dunson, David B AD - University of South Carolina ; National Institute of Environmental Health Sciences Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1158 EP - 1171 VL - 102 IS - 480 SN - 0162-1459, 0162-1459 KW - Anthropology KW - Model testing KW - Multivariate analysis KW - Medical research KW - Regression analysis KW - Statistical analysis KW - Data analysis KW - Statistical methods KW - Cancer KW - Bayesian method UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36816256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Statistical+Association&rft.atitle=Bayesian+multivariate+isotonic+regression+splines%3A+applications+to+carcinogenicity+studies&rft.au=Cai%2C+Bo%3BDunson%2C+David+B&rft.aulast=Cai&rft.aufirst=Bo&rft.date=2007-12-01&rft.volume=102&rft.issue=480&rft.spage=1158&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Statistical+Association&rft.issn=01621459&rft_id=info:doi/10.1198%2F016214506000000942 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12224 971; 1512 3865 4025; 8379 12224 971; 10739 12228 10919; 1939 3617 6220; 8160 8163; 3279 971 3286; 7886 10902 DO - http://dx.doi.org/10.1198/016214506000000942 ER - TY - JOUR T1 - Monitoring rare serious adverse events from a new treatment and testing for a difference from historical controls AN - 21331622; 10898611 AB - Background We detail the design of a study to monitor the safety of including albendazole to an existing treatment regimen to eliminate lymphatic filariasis. We wish to show that this new regimen does not increase the rate of a rare serious adverse event (SAE) compared to the old regimen. Controlled but small clinical trials have not detected any increase in the SAE using albendazole, and it is known to have added benefits; therefore, it is unethical to randomize patients to the old regimen.Purpose A sample size for the new regimen is needed to test that the new rate of SAE is noninferior to the historic rate. If the new regimen does have an inferior rate of SAE then we wish to stop the study early. This setup is different from traditional early stopping for efficacy and futility. In that traditional case, the two stopping decisions are relative to the same null hypothesis of equality, while in our setup, we have two different null hypotheses: the noninferiority null and the equality null. When testing the former, we need not stop early if the new regimen appears better because no subjects are receiving the old regimen anymore anyway. When testing the equality of SAE rates, however, we want to stop early if the new regimen has a significantly higher rate of SAE.Methods We create a design that uses an exact difference in proportions test for testing noninferiority, but calculates maximal sample size based on conditional power which treats the historical rates as true rates. The design allows for early stopping if the new treatment appears inferior with respect to SAE rate but makes no corrections for multiple testing. We explore the properties of this naive design without assuming the historical rates are known.Results For our example, we show that our naive design strategy bounds the type I error of the noninferiority hypothesis in all cases and bounds it for the equality hypothesis at 0.05, as long as the true SAE rate is <0.00015. The same design has unconditional power for the noninferiority hypothesis greater than the nominal 80% as long as the true SAE rate for both regimens are <0.00025.Limitations The type I and power results above hold only for our historical sample size of 17 877. We expect similar type I and power properties to hold with studies with SAE rates similar or less (i.e., < 0.00015) and historical sample sizes similar or smaller.Conclusions Our design for comparing very rare historical SAE rates to SAE rates of a new treatment has large power to conclude noninferiority of the new treatment SAE rate when both rates are equal, but allows early stopping if the new SAE rates are worse. Clinical Trials 2007; 4: 598-610. http://ctj.sagepub.com JF - Clinical Trials AU - Fay, Michael P AU - Huang, Chiung-Yu AU - Twum-Danso, Nana AY AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892-7609, USA, mfay@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 598 EP - 610 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU VL - 4 IS - 6 SN - 1740-7745, 1740-7745 KW - Health & Safety Science Abstracts KW - Historical account KW - safety engineering KW - Medical treatment KW - clinical trials KW - Side effects KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21331622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Monitoring+rare+serious+adverse+events+from+a+new+treatment+and+testing+for+a+difference+from+historical+controls&rft.au=Fay%2C+Michael+P%3BHuang%2C+Chiung-Yu%3BTwum-Danso%2C+Nana+AY&rft.aulast=Fay&rft.aufirst=Michael&rft.date=2007-12-01&rft.volume=4&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774507084978 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Medical treatment; Historical account; clinical trials; Side effects; safety engineering DO - http://dx.doi.org/10.1177/1740774507084978 ER - TY - JOUR T1 - Cholesterol Ester Storage Disease With Unusual Neurological Manifestations in Two Siblings: A Report From South India AN - 21206144; 11650183 AB - Cholesterol ester storage disease is a rare autosomal recessive storage disorder resulting from lysosomal acid lipase deficiency. Two siblings manifested with hepatosplenomegaly, ptosis, and bilateral external ophthalmoplegia. Evaluation revealed hyperlipidemia and bilateral adrenal calcifications. Leukocyte acid lipase levels were significantly low in both the patients, compared with controls, suggesting a diagnosis of cholesterol ester storage disease. Ptosis and external ophthalmoplegia have hitherto not been reported in cholesterol ester storage disease. JF - Journal of Child Neurology AU - Bindu, P S AU - Taly, AB AU - Christopher, R AU - BharatKumar, P V AU - Panda, S AU - Netravathi, M AU - Ravishankar, S AU - Mahadevan, A AU - Yasha, T C AU - Gayathri, N AD - Department of Neuropathology National Institute of Mental Health & Neurosciences, Bangalore, India Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1401 EP - 1404 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 22 IS - 12 SN - 0883-0738, 0883-0738 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - acid lipase KW - cholesterol ester storage disease KW - ophthalmoplegia KW - ptosis KW - Wolman disease KW - Triacylglycerol lipase KW - storage diseases KW - Calcification KW - Hereditary diseases KW - Hyperlipidemia KW - Leukocytes KW - Siblings KW - Cholesterol KW - Esters KW - Ophthalmoplegia KW - A 01490:Miscellaneous KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21206144?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Child+Neurology&rft.atitle=Cholesterol+Ester+Storage+Disease+With+Unusual+Neurological+Manifestations+in+Two+Siblings%3A+A+Report+From+South+India&rft.au=Bindu%2C+P+S%3BTaly%2C+AB%3BChristopher%2C+R%3BBharatKumar%2C+P+V%3BPanda%2C+S%3BNetravathi%2C+M%3BRavishankar%2C+S%3BMahadevan%2C+A%3BYasha%2C+T+C%3BGayathri%2C+N&rft.aulast=Bindu&rft.aufirst=P&rft.date=2007-12-01&rft.volume=22&rft.issue=12&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Journal+of+Child+Neurology&rft.issn=08830738&rft_id=info:doi/10.1177%2F0883073807307104 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Triacylglycerol lipase; storage diseases; Hereditary diseases; Calcification; Leukocytes; Hyperlipidemia; Siblings; Cholesterol; Ophthalmoplegia; Esters DO - http://dx.doi.org/10.1177/0883073807307104 ER - TY - JOUR T1 - Sensitivity of the erythrocyte micronucleus assay: Dependence on number of cells scored and inter-animal variability AN - 21055976; 7786314 AB - Until recently, the in vivo erythrocyte micronucleus assay has been scored using microscopy. Because the frequency of micronucleated cells is typically low, cell counts are subject to substantial binomial counting error. Counting error, along with inter-animal variability, limit the sensitivity of this assay. Recently, flow cytometric methods have been developed for scoring micronucleated erythrocytes and these methods enable many more cells to be evaluated than is possible with microscopic scoring. Using typical spontaneous micronucleus frequencies reported in mice, rats, and dogs we calculate the counting error associated with the frequency of micronucleated reticulocytes as a function of the number of reticulocytes scored. We compare this counting error with the inter-animal variability determined by flow cytometric scoring of sufficient numbers of cells to assure that the counting error is less than the inter-animal variability, and calculate the minimum increases in micronucleus frequency that can be detected as a function of the number of cells scored. The data show that current regulatory guidelines allow low power of the test when spontaneous frequencies are low (e.g., approximately equal to 0.1%). Tables and formulas are presented that provide the necessary numbers of cells that must be scored to meet the recommendation of the International Working Group on Genotoxicity Testing that sufficient cells be scored to reduce counting error to less than the inter-animal variability, thereby maintaining a more uniform power of detection of increased micronucleus frequencies across laboratories and species. JF - Mutation Research-Genetic Toxicology and Environmental Mutagenesis AU - Kissling, GE AU - Dertinger, S D AU - Hayashi, M AU - MacGregor, J T AD - Research Triangle Park, NC 27709, United States, kissling@niehs.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 235 EP - 240 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 634 IS - 1-2 SN - 1383-5718, 1383-5718 KW - Toxicology Abstracts KW - Flow cytometry KW - Data processing KW - Erythrocytes KW - Microscopy KW - Genotoxicity testing KW - Enumeration KW - Reticulocytes KW - Mutagenesis KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21055976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.atitle=Sensitivity+of+the+erythrocyte+micronucleus+assay%3A+Dependence+on+number+of+cells+scored+and+inter-animal+variability&rft.au=Kissling%2C+GE%3BDertinger%2C+S+D%3BHayashi%2C+M%3BMacGregor%2C+J+T&rft.aulast=Kissling&rft.aufirst=GE&rft.date=2007-12-01&rft.volume=634&rft.issue=1-2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Genetic+Toxicology+and+Environmental+Mutagenesis&rft.issn=13835718&rft_id=info:doi/10.1016%2Fj.mrgentox.2007.07.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Data processing; Microscopy; Erythrocytes; Genotoxicity testing; Enumeration; Reticulocytes; Mutagenesis DO - http://dx.doi.org/10.1016/j.mrgentox.2007.07.010 ER - TY - JOUR T1 - Chlamydia trachomatis Species-Specific Induction of Ezrin Tyrosine Phosphorylation Functions in Pathogen Entry AN - 21004659; 7932007 AB - Chlamydia trachomatis is an obligate intracellular pathogen of humans that exhibits species-specific biological characteristics in its early interactions with host cells that are likely important to pathogenesis. One such characteristic is the tyrosine phosphorylation (Tyr-P) of an similar to 70-kDa polypeptide that occurs only after infection of mammalian cells by human strains. We sought to identify this protein because of its potential significance to the pathogenesis of human chlamydial infections. Using an immunoproteomic approach we identified the host protein ezrin, a member of the ezrin-radixin-moesin (ERM) protein family that serves as a physical link between host cell receptors and the actin cytoskeleton. Confocal microscopy studies showed colocalization of ezrin and actin at the tips and crypts of microvilli, the site of chlamydial attachment and entry, respectively. To demonstrate a functional role for ezrin we infected cells with a dominant-negative (DN) ezrin phenotype or treated cells with ezrin-specific small interfering RNA (siRNA). We found that both DN and siRNA-treated cells were significantly less susceptible to infection by human chlamydial strains. Moreover, we demonstrated that inhibition of infection in ezrin DN cells occurred at the stage of chlamydial entry. We hypothesize that the C. trachomatis-specific Tyr-P of ezrin might relate to an undefined species-specific mechanism of pathogen entry that involves chlamydial specific ligand(s) and host cell coreceptor usage. JF - Infection and Immunity AU - Swanson, Kena A AU - Crane, Deborah D AU - Caldwell, Harlan D AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 58940 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 5669 EP - 5677 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - ezrin KW - Chlamydia trachomatis KW - Tyrosine KW - Pathogens KW - Infection KW - Cytoskeleton KW - ERM protein KW - Phosphorylation KW - siRNA KW - Mammalian cells KW - Confocal microscopy KW - Actin KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21004659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Chlamydia+trachomatis+Species-Specific+Induction+of+Ezrin+Tyrosine+Phosphorylation+Functions+in+Pathogen+Entry&rft.au=Swanson%2C+Kena+A%3BCrane%2C+Deborah+D%3BCaldwell%2C+Harlan+D&rft.aulast=Swanson&rft.aufirst=Kena&rft.date=2007-12-01&rft.volume=75&rft.issue=12&rft.spage=5669&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; ERM protein; ezrin; Mammalian cells; siRNA; Phosphorylation; Confocal microscopy; Tyrosine; Actin; Pathogens; Infection; Chlamydia trachomatis ER - TY - JOUR T1 - Genomics and the mechanism of P-glycoprotein (ABCB1) AN - 20987903; 8151181 AB - The development of effective clinical interventions against multidrug resistance (MDR) in cancer remains a significant challenge. Single nucleotide polymorphisms (SNPs) contribute to wide variations in how individuals respond to medications and there are several SNPs in human P-glycoprotein (P-gp) that may influence the interactions of drug-substrates with the transporter. Interestingly, even some of the synonymous SNPs have functional consequences for P-gp. It is also becoming increasingly evident that an understanding of the transport pathway of P-gp may be necessary to design effective modulators. In this review we discuss: (1) The potential importance of SNPs (both synonymous and non-synonymous) in MDR and (2) How new concepts that have emerged from structural studies with isolated nucleotide binding domains of bacterial ABC transporters have prompted biochemical studies on P-gp, leading to a better understanding of the mechanism of P-gp mediated transport. Our results suggest that the power-stroke is provided only after formation of the pre-hydrolysis transition-like (E.S) state during ATP hydrolysis. JF - Journal of Bioenergetics and Biomembranes AU - Sauna, Zuben E AU - Kim, In-Wha AU - Ambudkar, Suresh V AD - National Institutes of Health, DHHS, Building 37, Room 2120, 37 Convent Drive, Bethesda, MD, 20892-4256, USA, ambudkar@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 481 EP - 487 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 39 IS - 5-6 SN - 0145-479X, 0145-479X KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - P-Glycoprotein KW - Single-nucleotide polymorphism KW - ABC transporter KW - Reviews KW - ATP KW - Multidrug resistance KW - genomics KW - Hydrolysis KW - Cancer KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bioenergetics+and+Biomembranes&rft.atitle=Genomics+and+the+mechanism+of+P-glycoprotein+%28ABCB1%29&rft.au=Sauna%2C+Zuben+E%3BKim%2C+In-Wha%3BAmbudkar%2C+Suresh+V&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2007-12-01&rft.volume=39&rft.issue=5-6&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bioenergetics+and+Biomembranes&rft.issn=0145479X&rft_id=info:doi/10.1007%2Fs10863-007-9115-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - P-Glycoprotein; ABC transporter; Single-nucleotide polymorphism; Reviews; ATP; Multidrug resistance; genomics; Hydrolysis; Cancer DO - http://dx.doi.org/10.1007/s10863-007-9115-9 ER - TY - JOUR T1 - Robust Strategies for Automated AFM Force Curve Analysis-II: Adhesion-Influenced Indentation of Soft, Elastic Materials AN - 20823279; 8364259 AB - In the first of this two-part discourse on the extraction of elastic properties from atomic force microscopy (AFM) data, a scheme for automating the analysis of force-distance curves was introduced and experimentally validated for the Hertzian (i.e., linearly elastic and noninteractive probe-sample pairs) indentation of soft, inhomogeneous materials. In the presence of probe-sample adhesive interactions, which are common especially during retraction of the rigid tip from soft materials, the Hertzian models are no longer adequate. A number of theories (e.g., Johnson-Kendall-Roberts and Derjaguin-Muller-Toporov), covering the full range of sample compliance relative to adhesive force and tip radius, are available for analysis of such data. We incorporated Pietrement and Troyon's approximation (2000, 'General Equations Describing Elastic Indentation Depth and Normal Contact Stiffness Versus Load,' J. Colloid Interface Sci., 226(1), pp. 166-171) of the Maugis-Dugdale model into the automated procedure. The scheme developed for the processing of Hertzian data was extended to allow for adhesive contact by applying the Pietrement-Troyon equation. Retraction force-displacement data from the indentation of polyvinyl alcohol gels were processed using the customized software. Many of the retraction curves exhibited strong adhesive interactions that were absent in extension. We compared the values of Young's modulus extracted from the retraction data to the values obtained from the extension data and from macroscopic uniaxial compression tests. Application of adhesive contact models and the automated scheme to the retraction curves yielded average values of Young's modulus close to those obtained with Hertzian models for the extension curves. The Pietrement-Troyon equation provided a good fit to the data as indicated by small values of the mean-square error. The Maugis-Dugdale theory is capable of accurately modeling adhesive contact between a rigid spherical indenter and a soft, elastic sample. Pietrement and Troyon's empirical equation greatly simplifies the theory and renders it compatible with the general automation strategies that we developed for Hertzian analysis. Our comprehensive algorithm for automated extraction of Young's moduli from AFM indentation data has been expanded to recognize the presence of either adhesive or Hertzian behavior and apply the appropriate contact model. JF - Journal of Biomechanical Engineering, Transactions of the ASME AU - Lin, David C AU - Dimitriadis, Emilios K AU - Horkay, Ferenc AD - Laboratory of Integrative and Medical Biophysics, National Institutes of Health, 9 Memorial Drive, Building 9, Room 1E118, Bethesda, MD 20892 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 904 EP - 912 PB - American Society of Mechanical Engineers, United Engineering Center, 345 E. 47th St. New York NY 10017 USA, [URL:http://www.asme.org] VL - 129 IS - 6 SN - 0148-0731, 0148-0731 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Data processing KW - Colloids KW - Algorithms KW - atomic force microscopy KW - Automation KW - Compression KW - Gels KW - Polyvinyl alcohol KW - Computer programs KW - software KW - Adhesives KW - Mechanical properties KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20823279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.atitle=Robust+Strategies+for+Automated+AFM+Force+Curve+Analysis-II%3A+Adhesion-Influenced+Indentation+of+Soft%2C+Elastic+Materials&rft.au=Lin%2C+David+C%3BDimitriadis%2C+Emilios+K%3BHorkay%2C+Ferenc&rft.aulast=Lin&rft.aufirst=David&rft.date=2007-12-01&rft.volume=129&rft.issue=6&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanical+Engineering%2C+Transactions+of+the+ASME&rft.issn=01480731&rft_id=info:doi/10.1115%2F1.2800826 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Adhesives; Mathematical models; atomic force microscopy; Mechanical properties; Computer programs; Compression; Algorithms; software; Polyvinyl alcohol; Gels; Colloids; Automation DO - http://dx.doi.org/10.1115/1.2800826 ER - TY - JOUR T1 - Hock immunization: A humane alternative to mouse footpad injections AN - 20773171; 8243139 AB - Footpad injection is a commonly used immunization method in mice. Being relatively easy to do with well-characterized lymphatic drainage, it has become a very useful immunization protocol to study local immune responses in draining lymph nodes. However, its disadvantages include use of only hind feet as a routine site of immunization since mice use their fore feet for food handling, and exacerbation of inflammation and swelling at the injection site leading to unrelieved pain and distress since feet are weight-bearing structures. With increasingly stringent Institutional guidelines for animal manipulations, there is increasing need for more humane protocols. A novel immunization protocol involving injection into the hock, the lateral tarsal region just above the ankle, a non-weight bearing structure draining to the same lymph node as the footpad, retains the advantages of footpad immunization without its drawbacks. This study, comparing immune responses between footpad and hock immunization in six different inbred mouse strains to two different protein antigens and a heat-killed bacterium, shows that hock immunization is a better alternative to footpad immunization, inducing comparable immune responses and being considerably more humane. JF - Journal of Immunological Methods AU - Kamala, T AD - Room 111, LCMI, NIAID, NIH, 9000 Rockville Pike, Bethesda, MD 20892, United States, tkamala@niaid.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 204 EP - 214 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 328 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Food KW - Drainage KW - Ankle KW - Pain KW - Immunization KW - Lymph nodes KW - Inflammation KW - F 06900:Methods KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20773171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Hock+immunization%3A+A+humane+alternative+to+mouse+footpad+injections&rft.au=Kamala%2C+T&rft.aulast=Kamala&rft.aufirst=T&rft.date=2007-12-01&rft.volume=328&rft.issue=1-2&rft.spage=204&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2007.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drainage; Food; Pain; Ankle; Lymph nodes; Immunization; Inflammation DO - http://dx.doi.org/10.1016/j.jim.2007.08.004 ER - TY - JOUR T1 - Diet and risk of multiple myeloma in Connecticut women AN - 20736987; 7970544 AB - Multiple myeloma accounts for an estimated 19,900 incident cancer cases per year in the United States. A population-based case-control study, consisting of 179 incident cases and 691 controls, was conducted to examine the impact of diet on multiple myeloma risk. Diet was assessed using a food frequency questionnaire and odds ratios, 95% confidence intervals, and P-trends were calculated across quartiles of consumption. After controlling for potential confounders, we observed inverse associations for cooked tomatoes (P-trend = 0.002), cruciferous vegetables (P-trend = 0.01), fresh fish (P-trend < 0.001), alcohol (P-trend < 0.001), and vitamin A (P-trend < 0.001) with multiple myeloma risk. In contrast, consumption of cream soups (P-trend = 0.01), jello (P-trend = 0.01), ice cream (P-trend = 0.01), and pudding (P-trend < 0.001) were positively associated with multiple myeloma. Furthermore, there was a suggestion that carbohydrate intake may be positively associated, whereas vitamin D and calcium intake may be inversely associated, with multiple myeloma risk. Despite very limited data on dietary factors in relation to multiple myeloma, the findings from this study concur with previously published studies, suggesting an inverse association for consumption of fish, cruciferous vegetables and green vegetables, and a positive association for some dairy products. JF - Cancer Causes & Control AU - Hosgood, HDean AU - Baris, Dalsu AU - Zahm, Shelia Hoar AU - Zheng, Tongzhang AU - Cross, Amanda J AD - National Institutes of Health, 6120 Executive Blvd., EPS 8118, MCS 7240, Bethesda, MD, 20892-7240, USA, hosgoodd@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1065 EP - 1076 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 10 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Immunology Abstracts KW - Vegetables KW - Calcium KW - USA, Connecticut KW - Food KW - Dairy products KW - Lycopersicon esculentum KW - vitamins KW - Multiple myeloma KW - Soups KW - alcohols KW - Cream KW - Carbohydrates KW - Diets KW - Alcohol KW - Inventories KW - multiple myeloma KW - Cancer KW - Vitamin D KW - Ice cream KW - Vitamin A KW - Fish KW - Females KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20736987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Diet+and+risk+of+multiple+myeloma+in+Connecticut+women&rft.au=Hosgood%2C+HDean%3BBaris%2C+Dalsu%3BZahm%2C+Shelia+Hoar%3BZheng%2C+Tongzhang%3BCross%2C+Amanda+J&rft.aulast=Hosgood&rft.aufirst=HDean&rft.date=2007-12-01&rft.volume=18&rft.issue=10&rft.spage=1065&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9047-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Inventories; Vegetables; Calcium; Food; Dairy products; Cancer; Vitamin D; Multiple myeloma; Ice cream; Soups; Vitamin A; Cream; alcohols; Carbohydrates; Alcohol; vitamins; multiple myeloma; Fish; Females; Lycopersicon esculentum; USA, Connecticut DO - http://dx.doi.org/10.1007/s10552-007-9047-z ER - TY - JOUR T1 - Dairy Products, Calcium Intake, and Risk of Prostate Cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial AN - 20726371; 7933576 AB - Higher intakes of calcium and dairy products, a major source of dietary calcium, are reported to increase the risk of prostate cancer, potentially due to reductions in circulating vitamin D with increasing calcium intake. We prospectively examined the association of dairy product and calcium intake with prostate cancer risk in 29,509 men, including 1,910 cases, in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. We also evaluated the relation of calcium intake with serum 25-hydroxy-vitamin D [25(OH)D] and 1,25-dihydroxy-vitamin D [1,25(OH) sub(2)D], in a Prostate, Lung, Colorectal, and Ovarian Trial substudy (n = 275). Dietary intake was assessed using a food frequency questionnaire. Baseline serum 1,25(OH) sub(2)D was determined by RIA. Greater intake of dairy products, particularly low-fat dairy products, was weakly associated with increased risk of prostate cancer [relative risk (RR), 1.12; 95% confidence intervals (CI), 0.97-1.30; P trend = 0.06 for >2.75 versus less than or equal to 0.98 servings of total dairy/day; 1.23 (1.07-1.41) for low-fat dairy]. Greater dietary calcium intake was associated with increased risk of prostate cancer (RR, 1.34; 95% CI, 0.93-1.94; P trend = 0.02 for >2,000 versus <1,000 mg/day), but greater supplementary calcium intake was not associated with the risk. Associations of dairy product and dietary calcium intake were evident for nonaggressive disease (RR, 1.20; 95% CI, 0.99-1.46; P trend = 0.01 for dairy products; 1.64, 1.04-2.57; P trend = 0.002 for dietary calcium), but not aggressive disease (RR, 1.02; 95% CI, 0.81-1.28 for dairy products; 0.94, 0.49-1.80 for dietary calcium). Calcium intake was not associated with serum 25-hydroxy-vitamin D and 1,25(OH) sub(2)D concentration. In this large prospective study in a prostate cancer screening trial, greater dietary intake of calcium and dairy products, particularly low-fat types, may be modestly associated with increased risks for nonaggressive prostate cancer, but was unrelated to aggressive disease. Furthermore, we found no relationship between calcium intake and circulating vitamin D. (Cancer Epidemiol Biomarkers Prev 2007; 16(12):2623-30) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Ahn, Jiyoung AU - Albanes, Demetrius AU - Peters, Ulrike AU - Schatzkin, Arthur AU - Lim, Unhee AU - Freedman, Michal AU - Chatterjee, Nilanjan AU - Andriole, Gerald L AU - Leitzmann, Michael F AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2623 EP - 2630 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 12 SN - 1055-9965, 1055-9965 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Bioindicators KW - Risk assessment KW - Ovarian cancer KW - Inventories KW - Calcium KW - ovarian carcinoma KW - Food KW - Dairy products KW - Ingestion KW - Dietary intake KW - biomarkers KW - Cancer KW - Dairies KW - vitamins KW - Prostate cancer KW - Calcium (dietary) KW - Vitamin D KW - Lung KW - prevention KW - prostate cancer KW - R2 23110:Psychological aspects KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Dairy+Products%2C+Calcium+Intake%2C+and+Risk+of+Prostate+Cancer+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial&rft.au=Ahn%2C+Jiyoung%3BAlbanes%2C+Demetrius%3BPeters%2C+Ulrike%3BSchatzkin%2C+Arthur%3BLim%2C+Unhee%3BFreedman%2C+Michal%3BChatterjee%2C+Nilanjan%3BAndriole%2C+Gerald+L%3BLeitzmann%2C+Michael+F%3BHayes%2C+Richard+B&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2623&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inventories; Ovarian cancer; Vitamin D; Calcium (dietary); Prostate cancer; Lung; Food; Dairy products; biomarkers; Dietary intake; Bioindicators; Diets; Dairies; vitamins; Calcium; ovarian carcinoma; prevention; Ingestion; prostate cancer; Cancer ER - TY - JOUR T1 - Single-nucleotide polymorphisms in selected cytokine genes and risk of adult glioma AN - 20724372; 7933525 AB - A role of immunological factors in glioma etiology is suggested by reports of an inverse relationship with history of allergy or autoimmune disease. To test whether single-nucleotide polymorphisms (SNPs) in cytokine genes were related to risk of adult glioma, we genotyped 11 SNPs in seven cytokine genes within a hospital-based study conducted by the National Cancer Institute and an independent, population-based study by the National Institute for Occupational Safety and Health (overall 756 cases and 1190 controls with blood samples). The IL4 (rs2243248, -1098T>G) and IL6 (rs1800795, -174G>C) polymorphisms were significantly associated with risk of glioma in the pooled analysis (P trend = 0.006 and 0.04, respectively), although these became attenuated after controlling for the false discovery rate (P trend = 0.07 and 0.22, respectively). Our results underscore the importance of pooled analyses in genetic association studies and suggest that SNPs in cytokine genes may influence susceptibility to glioma. JF - Carcinogenesis AU - Brenner, A V AU - Butler, MA AU - Wang, S S AU - Ruder, A M AU - Rothman, N AU - Schulte, P A AU - Chanock, S J AU - Fine, HA AU - Linet AU - Inskip, P D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7238, USA. Division of Applied Research and Technology, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Education and Information Division, National Institute for Occupational Safety and Health, CDC, DHHS, Cincinnati, OH, 45226, USA. Core Genotyping Facility, Advanced Technology Corporation, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, 20892-4605, USA. Neurooncology Branch, Center for Cancer Research, National Cancer Institute, NIH, DHHS, Bethesda, MD, 20892-8200, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2543 EP - 2547 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 12 SN - 0143-3334, 0143-3334 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; CSA Neurosciences Abstracts; Immunology Abstracts KW - Interleukin 6 KW - Historical account KW - Interleukin 4 KW - Etiology KW - Occupational safety KW - Autoimmune diseases KW - autoimmune diseases KW - Population studies KW - Allergies KW - Cancer KW - Brain tumors KW - glioma KW - Hypersensitivity KW - Single-nucleotide polymorphism KW - Carcinogenesis KW - Cytokines KW - Glioma KW - G 07720:Immunogenetics KW - F 06925:Hypersensitivity KW - H 1000:Occupational Safety and Health KW - N 14845:Miscellaneous KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Single-nucleotide+polymorphisms+in+selected+cytokine+genes+and+risk+of+adult+glioma&rft.au=Brenner%2C+A+V%3BButler%2C+MA%3BWang%2C+S+S%3BRuder%2C+A+M%3BRothman%2C+N%3BSchulte%2C+P+A%3BChanock%2C+S+J%3BFine%2C+HA%3BLinet%3BInskip%2C+P+D&rft.aulast=Brenner&rft.aufirst=A&rft.date=2007-12-01&rft.volume=28&rft.issue=12&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Brain tumors; Etiology; Hypersensitivity; Interleukin 4; Single-nucleotide polymorphism; Autoimmune diseases; Carcinogenesis; Population studies; Cytokines; Glioma; Historical account; glioma; Occupational safety; autoimmune diseases; Allergies; Cancer ER - TY - JOUR T1 - Calcium, Dairy Foods, and Risk of Incident and Fatal Prostate Cancer: The NIH-AARP Diet and Health Study AN - 20723956; 7928759 AB - Calcium and dairy foods in relation to prostate cancer were examined in the National Institutes of Health (NIH)-AARP (formerly known as the American Association of Retired Persons) Diet and Health Study (1995/1996-2001). Diet was assessed with a food frequency questionnaire at baseline. Multivariate relative risks and 95% confidence intervals were estimated by Cox regression. During up to 6 years of follow-up (n = 293,888), the authors identified 10,180 total prostate cancer cases (8,754 nonadvanced, 1,426 advanced, and 178 fatal cases). Total and supplemental calcium were unrelated to total and nonadvanced prostate cancer. However, a statistically nonsignificant positive association with total calcium was observed for advanced ( greater than or equal to 2,000 vs. 500-<750 mg/day: relative risk (RR) = 1.25, 95% confidence interval (CI): 0.91, 1.71; p sub(trend) = 0.06) and fatal ( greater than or equal to 1,000 vs. 500-<750 mg/day: RR = 1.39, 95% CI: 0.92, 2.09; p sub(trend) = 0.10) prostate cancer. Skim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer ( greater than or equal to 2 vs. zero servings/day: RR = 1.23, 95% CI: 0.99, 1.54; p sub(trend) = 0.01). In contrast, calcium from nondairy foods was associated with lower risk of nonadvanced prostate cancer ( greater than or equal to 600 vs. <250 mg/day: RR = 0.82, 95% CI: 0.68, 0.99; p sub(trend) = 0.04). Although the authors cannot definitively rule out a weak association for aggressive prostate cancer, their findings do not provide strong support for the hypothesis that calcium and dairy foods increase prostate cancer risk. JF - American Journal of Epidemiology AU - Park, Yikyung AU - Mitrou, Panagiota N AU - Kipnis, Victor AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Leitzmann, Michael F AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 1270 EP - 1279 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 11 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Calcium & Calcified Tissue Abstracts KW - Diets KW - Risk assessment KW - Inventories KW - Milk KW - Calcium KW - Food KW - Dairy products KW - Skim milk KW - Dairies KW - Prostate cancer KW - Risk factors KW - prostate cancer KW - R2 23110:Psychological aspects KW - T 2020:Nutrition and Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Calcium%2C+Dairy+Foods%2C+and+Risk+of+Incident+and+Fatal+Prostate+Cancer%3A+The+NIH-AARP+Diet+and+Health+Study&rft.au=Park%2C+Yikyung%3BMitrou%2C+Panagiota+N%3BKipnis%2C+Victor%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BLeitzmann%2C+Michael+F&rft.aulast=Park&rft.aufirst=Yikyung&rft.date=2007-12-01&rft.volume=166&rft.issue=11&rft.spage=1270&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Risk assessment; Diets; Inventories; Dairies; Calcium; Prostate cancer; Risk factors; Food; Dairy products; Skim milk; Milk; prostate cancer ER - TY - JOUR T1 - Toxicity of Panax Genseng - An Herbal Medicine and Dietary Supplement AN - 20683945; 8111330 AB - Ginseng is one of the most popular herbal dietary supplements in the U.S. market, with five to six million persons using it even before the recent boom in the herbal supplement industry. Ginsana (G115 ginseng), a standardized extract of Panax ginseng (Asian ginseng, also called Chinese or Korean ginseng) controls half of this market. Numerous reports of adverse effects from products containing ginseng have been filed with the U.S. Food and Drug Administration (FDA). The literature also documents "ginseng abuse syndrome" among regular users. The chronic effects of ginseng are not well characterized. Because of its significant human exposure and little information on toxicity is available, Panax ginseng has been nominated by the U.S. National Institutes of Health (NIH) to the U.S. National Toxicology Program (NTP) for assessing its carcinogenic potential. In this review, we discuss the environmental occurrence, purported therapeutic effects, biological effects, and toxicity of ginseng, with focus on Panax ginseng. To demonstrate how NTP chronic tumorigenicity bioassays are conducted, the tumorigenicity bioassay of Panax ginseng is detailed described. JF - Journal of Food and Drug Analysis AU - Chan, P-C AU - Fu, P P AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, chanp@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 416 EP - 427 VL - 15 IS - 4 SN - 1021-9498, 1021-9498 KW - Toxicology Abstracts; Health & Safety Science Abstracts KW - Panax ginseng KW - dietary supplements KW - herbal medicines KW - biological effects KW - Tumorigenicity KW - Panax KW - Ginseng KW - Toxicity KW - Abuse KW - USA KW - Bioassays KW - Carcinogenicity KW - Reviews KW - Dietary supplements KW - Chronic effects KW - FDA KW - Herbal medicines KW - Drugs KW - Toxicology KW - Side effects KW - H 14000:Toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20683945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Food+and+Drug+Analysis&rft.atitle=Toxicity+of+Panax+Genseng+-+An+Herbal+Medicine+and+Dietary+Supplement&rft.au=Chan%2C+P-C%3BFu%2C+P+P&rft.aulast=Chan&rft.aufirst=P-C&rft.date=2007-12-01&rft.volume=15&rft.issue=4&rft.spage=416&rft.isbn=&rft.btitle=&rft.title=Journal+of+Food+and+Drug+Analysis&rft.issn=10219498&rft_id=info:doi/ LA - Chinese DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Chronic effects; Dietary supplements; Herbal medicines; Tumorigenicity; Ginseng; Toxicity; Abuse; Side effects; Bioassays; herbal medicines; dietary supplements; biological effects; Carcinogenicity; Reviews; FDA; Drugs; Toxicology; Panax ginseng; Panax; USA ER - TY - JOUR T1 - Advocacy for Malaria Prevention, Control, and Research in the Twenty-First Century AN - 20676236; 8015395 AB - Until recent years, public interest and political investment in malaria prevention, control, and research have been stagnant. The global malaria agenda is now experiencing an unprecedented time of public and political will and momentum. At the heart of this favorable period lies a nascent, but increasingly sophisticated, global advocacy effort that has contributed to new and expanded malaria funding, programs, and technology. This paper reviews the elements of malaria's rise to political and public prominence, tracks the increase in funding and policy commitments to malaria over the past decade, and comments on an evolving policymaking progress, increasing transparency and accountability in program governance, and the impact of philanthropic investments in malaria advocacy. In addition, the principles of sound advocacy are described along with the mechanisms that will underlie sustained pro-political momentum for malaria research, resources, and results. "Today, we have begun to write the final chapter in the history of malaria. We have raised hopes and expectations of our people--we must not let them down. We cannot afford to let them down." --His Excellency Olusegan Obasanjo, President of Nigeria, Abuja Summit 2000. JF - American Journal of Tropical Medicine and Hygiene AU - Bates, N AU - Herrington, J AD - Fogarty International Center, Bldg. 31, Rm. B2C11, National Institutes of Health, Bethesda, MD 20892-2220, USA, herringtonj@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 314 EP - 320 VL - 77 SN - 0002-9637, 0002-9637 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Nigeria KW - Human diseases KW - Policies KW - Sociological aspects KW - Financing KW - Sound KW - Disease control KW - Malaria KW - Public health KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20676236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Advocacy+for+Malaria+Prevention%2C+Control%2C+and+Research+in+the+Twenty-First+Century&rft.au=Bates%2C+N%3BHerrington%2C+J&rft.aulast=Bates&rft.aufirst=N&rft.date=2007-12-01&rft.volume=77&rft.issue=&rft.spage=314&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - SuppNotes - Special Issue: Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives. N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Policies; Human diseases; Sociological aspects; Financing; Disease control; Malaria; Public health; Sound; Nigeria ER - TY - JOUR T1 - Genetic and functional analysis of CHEK2 (CHK2) variants in multiethnic cohorts AN - 20651489; 8079799 AB - The CHEK2-1100delC mutation is recurrent in the population and is a moderate risk factor for breast cancer. To identify additional CHEK2 mutations potentially contributing to breast cancer susceptibility, we sequenced 248 cases with early-onset disease; functionally characterized new variants and conducted a population-based case-control analysis to evaluate their contribution to breast cancer risk. We identified 1 additional null mutation and 5 missense variants in the germline of cancer patients. In vitro, the CHEK2-H143Y variant resulted in gross protein destabilization, while others had variable suppression of in vitro kinase activity using BRCA1 as a substrate. The germline CHEK2-1100delC mutation was present among 8/1,646 (0.5%) sporadic, 2/400 (0.5%) early-onset and 3/302 (1%) familial breast cancer cases, but undetectable amongst 2,105 multiethnic controls, including 633 from the US. CHEK2-positive breast cancer families also carried a deleterious BRCA1 mutation. 1100delC appears to be the only recurrent CHEK2 mutation associated with a potentially significant contribution to breast cancer risk in the general population. Another recurrent mutation with attenuated in vitro function, CHEK2-P85L, is not associated with increased breast cancer susceptibility, but exhibits a striking difference in frequency across populations with different ancestral histories. These observations illustrate the importance of genotyping ethnically diverse groups when assessing the impact of low-penetrance susceptibility alleles on population risk. Our findings highlight the notion that clinical testing for rare missense mutations within CHEK2 may have limited value in predicting breast cancer risk, but that testing for the 1100delC variant may be valuable in phenotypically- and geographically-selected populations. JF - International Journal of Cancer AU - Bell, Daphne W AU - Kim, Sang H AU - Godwin, Andrew K AU - Schiripo, Taryn A AU - Harris, Patricia L AU - Haserlat, Sara M AU - Wahrer, Doke C R AU - Haiman, Christopher A AU - Daly, Mary B AU - Niendorf, Kristin B AU - Smith, Matthew R AU - Sgroi, Dennis C AU - Garber, Judy E AU - Olopade, Olufunmilayo I AU - Le Marchand, Loic AU - Henderson, Brian E AU - Altshuler, David AU - Haber, Daniel A AU - Freedman, Matthew L AD - Massachusetts General Hospital Cancer Center, Charlestown, MA, belldaph@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2661 EP - 2667 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 12 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts KW - Historical account KW - Age KW - Missense mutation KW - Genotyping KW - functional analysis KW - Population genetics KW - Risk factors KW - Proteins KW - Breast cancer KW - BRCA1 protein KW - Mutation KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20651489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Genetic+and+functional+analysis+of+CHEK2+%28CHK2%29+variants+in+multiethnic+cohorts&rft.au=Bell%2C+Daphne+W%3BKim%2C+Sang+H%3BGodwin%2C+Andrew+K%3BSchiripo%2C+Taryn+A%3BHarris%2C+Patricia+L%3BHaserlat%2C+Sara+M%3BWahrer%2C+Doke+C+R%3BHaiman%2C+Christopher+A%3BDaly%2C+Mary+B%3BNiendorf%2C+Kristin+B%3BSmith%2C+Matthew+R%3BSgroi%2C+Dennis+C%3BGarber%2C+Judy+E%3BOlopade%2C+Olufunmilayo+I%3BLe+Marchand%2C+Loic%3BHenderson%2C+Brian+E%3BAltshuler%2C+David%3BHaber%2C+Daniel+A%3BFreedman%2C+Matthew+L&rft.aulast=Bell&rft.aufirst=Daphne&rft.date=2007-12-01&rft.volume=121&rft.issue=12&rft.spage=2661&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.23026 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Population genetics; Missense mutation; Age; Risk factors; Genotyping; BRCA1 protein; Breast cancer; Historical account; Proteins; functional analysis; Mutation DO - http://dx.doi.org/10.1002/ijc.23026 ER - TY - JOUR T1 - Common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, and susceptibility to breast cancer AN - 20650287; 8079780 AB - Germline mutations in the tumor suppressor gene TP53 are associated with high incidence of early-onset malignancies, and somatic mutations occur in 20-40% of all breast cancer cases. We investigated the association of common genetic variation in TP53 and its flanking genes, WDR79 and ATP1B2, with risk for breast cancer. Single nucleotide polymorphisms (SNPs) identified in a re-sequence analysis were genotyped in 2 large case-control studies including 731 cases and 1,124 controls from Norway, and 1,995 cases and 2,296 controls from Poland. Analyses of the pooled data showed no SNPs in TP53 to be significantly associated with risk for breast cancer. However, we found a significant and consistent association with risk for a SNP in exon 1 (R68G) of the 5 neighboring gene WDR79 (rs2287499, OR (95% CI) = 1.08 (0.95-1.23) for CG vs. CC and 1.60 (1.04-2.47) for GG vs. CC, p-trend = 0.01). Stratification by ER and PR status, showed these increases in risk to be limited to ER negative tumors (OR (95% CI) per variant allele: 1.42 (1.18-1.71) p-trend = 0.00009). In addition, 2 TP53 SNPs (rs17887200 3of STP and rs12951053 in intron 7) showing weak and non-significant overall increases in risk, were also associated with ER negative tumors (1.48 (1.11-1.93) p-trend = 0.01 and 1.29 (1.06-1.58) p-trend = 0.009, respectively). In conclusion, this comprehensive evaluation of common genetic variation in TP53 and its flanking genes found no significant overall associations between SNPs in TP53 and breast cancer risk. However, data suggested that common variation in TP53 or WDR79 could be associated with ER negative breast cancers. JF - International Journal of Cancer AU - Garcia-Closas, Montserrat AU - Kristensen, Vessela AU - Langerod, Anita AU - Qi, Ying AU - Yeager, Meredith AU - Burdett, Laurie AU - Welch, Robert AU - Lissowska, Jolanta AU - Peplonska, Beata AU - Brinton, Louise AU - Gerhard, Daniela S AU - Gram, Inger Torhild AU - Perou, Charles M AU - Borresen-Dale, Anne-Lise AU - Chanock, Stephen AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, garciacm@exchange.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2532 EP - 2538 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 11 SN - 0020-7136, 0020-7136 KW - Genetics Abstracts; Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Age KW - Exons KW - Genetic diversity KW - genetic diversity KW - Stratification KW - Tumors KW - p53 protein KW - Malignancy KW - introns KW - Single-nucleotide polymorphism KW - Poland KW - Introns KW - Breast cancer KW - Norway KW - Mutation KW - G 07880:Human Genetics KW - B 26670:Tumor Suppressors KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20650287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Common+genetic+variation+in+TP53+and+its+flanking+genes%2C+WDR79+and+ATP1B2%2C+and+susceptibility+to+breast+cancer&rft.au=Garcia-Closas%2C+Montserrat%3BKristensen%2C+Vessela%3BLangerod%2C+Anita%3BQi%2C+Ying%3BYeager%2C+Meredith%3BBurdett%2C+Laurie%3BWelch%2C+Robert%3BLissowska%2C+Jolanta%3BPeplonska%2C+Beata%3BBrinton%2C+Louise%3BGerhard%2C+Daniela+S%3BGram%2C+Inger+Torhild%3BPerou%2C+Charles+M%3BBorresen-Dale%2C+Anne-Lise%3BChanock%2C+Stephen&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2007-12-01&rft.volume=121&rft.issue=11&rft.spage=2532&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22985 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Age; Malignancy; Exons; Single-nucleotide polymorphism; Introns; Genetic diversity; Breast cancer; Tumors; Mutation; p53 protein; introns; genetic diversity; Stratification; Poland; Norway DO - http://dx.doi.org/10.1002/ijc.22985 ER - TY - JOUR T1 - Fruit and vegetable intake and esophageal cancer in a large prospective cohort study AN - 20624182; 8079813 AB - Changing patterns of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) incidence worldwide suggest distinct etiologies. Although associations between fruit and vegetable intake and both ESCC and EAC have been found in multiple ecological and case-control studies, few prospective studies have investigated these associations. We prospectively examined these associations in 490,802 participants of the National Institutes of Health (NIH)-AARP Diet and Health Study using Cox models adjusted for age, alcohol intake, body mass index, cigarette smoking, education, physical activity and total energy intake. We present hazard ratios and 95% confidence intervals per serving per 1,000 calories. During 2,193,751 person years of follow-up, 103 participants were diagnosed with ESCC and 213 participants with EAC. We found a significant inverse association between total fruit and vegetable intake and ESCC risk (HR: 0.78, 95% CI: 0.67-0.91), but not EAC risk (0.9,0.90-1.08). In models mutually adjusted for fruit and vegetable intake, the protective association with ESCC was stronger for fruits (0.7,0.57-0.93) than for vegetables (0.8,0.66-1.07). When we examined botanical subgroups, we observed significant protective associations for ESCC and intake of Rosacea (apples, peaches, nectarines, plums, pears and strawberries) and Rutaceae (citrus fruits). A significant inverse association between EAC and Chenopodiaceae (spinach) intake was observed. Results from our study suggest that the relation of fruit and vegetable intake and esophageal cancer risk may vary by histologic type. JF - International Journal of Cancer AU - Freedman, Neal D AU - Park, Yikyung AU - Subar, Amy F AU - Hollenbeck, Albert R AU - Leitzmann, Michael F AU - Schatzkin, Arthur AU - Abnet, Christian C AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD, freedmanne@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2753 EP - 2760 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 12 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Rutaceae KW - Citrus KW - Age KW - Fragaria KW - Prunus KW - Rosacea KW - Chenopodiaceae KW - body mass KW - Cigarette smoking KW - Spinacia oleracea KW - physical activity KW - Diets KW - Alcohol KW - Etiology KW - fruits KW - Cancer KW - Education KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20624182?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Fruit+and+vegetable+intake+and+esophageal+cancer+in+a+large+prospective+cohort+study&rft.au=Freedman%2C+Neal+D%3BPark%2C+Yikyung%3BSubar%2C+Amy+F%3BHollenbeck%2C+Albert+R%3BLeitzmann%2C+Michael+F%3BSchatzkin%2C+Arthur%3BAbnet%2C+Christian+C&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-12-01&rft.volume=121&rft.issue=12&rft.spage=2753&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22993 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Citrus; Prunus; Chenopodiaceae; Spinacia oleracea; Rutaceae; Fragaria; Rosacea; fruits; Cancer; Alcohol; Diets; Education; Cigarette smoking; body mass; physical activity; Age; Etiology DO - http://dx.doi.org/10.1002/ijc.22993 ER - TY - JOUR T1 - A semiparametric pseudo-score method for analysis of two-phase studies with continuous phase-I covariates AN - 20596664; 8148224 AB - Two-phase study designs can reduce cost and other practical burdens associated with large scale epidemiologic studies by limiting ascertainment of expensive covariates to a smaller but informative sub-sample (phase-II) of the main study (phase-I). During the analysis of such studies, however, subjects who are selected at phase-I but not at phase-II, remain informative as they may have partial covariate information. A variety of semi-parametric methods now exist for incorporating such data from phase-I subjects when the covariate information can be summarized into a finite number of strata. In this article, we consider extending the pseudo-score approach proposed by Chatterjee et al. (J Am Stat Assoc 98:158-168, 2003) using a kernel smoothing approach to incorporate information on continuous phase-I covariates. Practical issues and algorithms for implementing the methods using existing software are discussed. A sandwich-type variance estimator based on the influence function representation of the pseudo-score function is proposed. Finite sample performance of the methods are studies using simulated data. Advantage of the proposed smoothing approach over alternative methods that use discretized phase-I covariate information is illustrated using two-phase data simulated within the National Wilms Tumor Study (NWTS). JF - Lifetime Data Analysis AU - Chatterjee, Nilanjan AU - Chen, Yi-Hau AD - National Cancer Institute, NIH, DHHS, Rockville, MD, 20852, USA, chattern@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 607 EP - 622 PB - Kluwer Academic Publishers, [mailto:sales@wkap.nl], [URL:http://www.kluweronline.com/] VL - 13 IS - 4 SN - 1380-7870, 1380-7870 KW - Microbiology Abstracts B: Bacteriology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20596664?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lifetime+Data+Analysis&rft.atitle=A+semiparametric+pseudo-score+method+for+analysis+of+two-phase+studies+with+continuous+phase-I+covariates&rft.au=Chatterjee%2C+Nilanjan%3BChen%2C+Yi-Hau&rft.aulast=Chatterjee&rft.aufirst=Nilanjan&rft.date=2007-12-01&rft.volume=13&rft.issue=4&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Lifetime+Data+Analysis&rft.issn=13807870&rft_id=info:doi/10.1007%2Fs10985-007-9066-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1007/s10985-007-9066-9 ER - TY - JOUR T1 - Overview of monoclonal B-cell lymphocytosis AN - 20588748; 7978368 AB - Monoclonal B-cell lymphocytosis (MBL) has been the subject of more intensive investigation for the last 10 years. The increased presence of MBL in unaffected, first-degree relatives with familial chronic lymphocytic leukaemia (CLL) suggest that it is surrogate marker for early disease. In normal population studies, MBL is found to be increased in ageing subjects. Consensus criteria for the diagnosis of MBL have been proposed. The differential diagnosis has been further clarified and the prevalence of MBL is most prominent in the elderly. The aetiology of MBL is unknown but probably involves immune mechanism of senescence or altered response. Environmental health studies suggest that exposure to certain toxins may lead to MBL but further work is needed. MBL is a precursor to CLL but may also regress, remain stable or progress to clinical CLL. JF - British Journal of Haematology AU - Marti, Gerald AU - Abbasi, Fatima AU - Raveche, Elizabeth AU - Rawstron, Andy C AU - Ghia, Paolo AU - Aurran, Therese AU - Caporaso, Neil AU - Shim, Youn K AU - Vogt, Robert F AD - Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration (FDA), NIH, Bethesda, MD, gemarti@helix.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 701 EP - 708 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 139 IS - 5 SN - 0007-1048, 0007-1048 KW - Health & Safety Science Abstracts; Immunology Abstracts KW - chronic lymphocytic leukaemia KW - monoclonal B-cell lymphocytosis KW - Lymphocytes B KW - Aging KW - Environmental health KW - Population studies KW - Toxins KW - population studies KW - Leukemia KW - Lymphocytosis KW - Differential diagnosis KW - Reviews KW - senescence KW - Geriatrics KW - Senescence KW - elderly KW - Chronic lymphatic leukemia KW - F 06915:Cancer Immunology KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=Overview+of+monoclonal+B-cell+lymphocytosis&rft.au=Marti%2C+Gerald%3BAbbasi%2C+Fatima%3BRaveche%2C+Elizabeth%3BRawstron%2C+Andy+C%3BGhia%2C+Paolo%3BAurran%2C+Therese%3BCaporaso%2C+Neil%3BShim%2C+Youn+K%3BVogt%2C+Robert+F&rft.aulast=Marti&rft.aufirst=Gerald&rft.date=2007-12-01&rft.volume=139&rft.issue=5&rft.spage=701&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2007.06865.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Differential diagnosis; Lymphocytosis; Lymphocytes B; Reviews; Aging; Geriatrics; Population studies; Senescence; Chronic lymphatic leukemia; Toxins; population studies; Leukemia; senescence; Environmental health; elderly DO - http://dx.doi.org/10.1111/j.1365-2141.2007.06865.x ER - TY - JOUR T1 - Efficient Systemic Expression of Bioactive 1L-15 in Mice upon Delivery of Optimized DNA Expression Plasmids AN - 20588687; 7965529 AB - Efficient expression vectors for interleukin 15 (IL-15) were developed combining RNA/codon optimization and modification of the IL-15 native long signal peptide. These changes resulted in elevated cytoplasmic levels of the optimized mRNA and more than 100-fold improved production of secreted human IL-15 protein. Similar modifications have also led to greatly increased rhesus macaque and murine IL-15 production. Comparison of different heterologous secretory signals showed that the tissue plasminogen activator signal is most efficient for the production of extracellular IL-15. Upon intramuscular injection of the fully optimized expression vectors in mice, IL-15 was readily detected in the serum. Serum levels represented <1% of intramuscular IL-15 and were sufficient in causing some systemic effects, such as increasing the frequency of natural killer (NK) cells in the liver. Upon hydrodynamic DNA delivery in mice, very high levels of IL-15 were produced, which increased the frequency of NK cells in liver as well as in spleen and lung. These optimized expression vectors have potential applications in vaccine and immunotherapy approaches against AIDS and cancer. JF - DNA and Cell Biology AU - Jalah, R AU - Rosati, M AU - Kulkami, V AU - Patel, V AU - Bergamaschi, C AU - Valentin, A AU - Zhang, G-M AU - Sidhu, M K AU - Eldridge, J H AU - Weiner, D B AU - Pavlakis, G N AU - Felber, B K AD - Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, 1050 Boyles St., Building 535, Room 209, Frederick, MD 21702-1201, USA, felber@ncifcrf.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 827 EP - 840 VL - 26 IS - 12 SN - 1044-5498, 1044-5498 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Hydrodynamics KW - Hepatocytes KW - Immunotherapy KW - Signal peptides KW - Natural killer cells KW - Spleen KW - Plasmids KW - t-Plasminogen activator KW - Cancer KW - mRNA KW - Expression vectors KW - Serum levels KW - Interleukin 15 KW - Lung KW - Codons KW - DNA KW - Macaca mulatta KW - Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20588687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+and+Cell+Biology&rft.atitle=Efficient+Systemic+Expression+of+Bioactive+1L-15+in+Mice+upon+Delivery+of+Optimized+DNA+Expression+Plasmids&rft.au=Jalah%2C+R%3BRosati%2C+M%3BKulkami%2C+V%3BPatel%2C+V%3BBergamaschi%2C+C%3BValentin%2C+A%3BZhang%2C+G-M%3BSidhu%2C+M+K%3BEldridge%2C+J+H%3BWeiner%2C+D+B%3BPavlakis%2C+G+N%3BFelber%2C+B+K&rft.aulast=Jalah&rft.aufirst=R&rft.date=2007-12-01&rft.volume=26&rft.issue=12&rft.spage=827&rft.isbn=&rft.btitle=&rft.title=DNA+and+Cell+Biology&rft.issn=10445498&rft_id=info:doi/10.1089%2Fdna.2007.0645 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Hydrodynamics; Hepatocytes; Immunotherapy; Signal peptides; Natural killer cells; Spleen; Plasmids; t-Plasminogen activator; Cancer; mRNA; Serum levels; Expression vectors; Interleukin 15; Lung; DNA; Codons; Vaccines; Macaca mulatta DO - http://dx.doi.org/10.1089/dna.2007.0645 ER - TY - JOUR T1 - Optimization of multiphoton excitation microscopy by total emission detection using a parabolic light reflector AN - 20565526; 8056756 AB - We have constructed a device that maximizes the probability of collecting all of the scattered and ballistic light isotropically generated at the focal spot of multiphoton excited emissions (MPE) to optimize the signal-to-noise ratio (SNR) for micro-imaging. This was accomplished by optically coupling a parabolic reflector (that surrounds the sample and top of the objective) to a pair of collimating lenses (above the sample) that redirects emitted light to a separate detector. These additional optics, combined with the objective, allow the total emission detection (TED) condition to be approached. Numerical simulations suggest an approximately 10-fold improvement in SNR with TED. Comparisons between the objective detection and TED reveal an enhancement of 8.9 in SNR (77% of predicted) for GFP-labelled brain slices and similar results for fluorescent beads. This increase in SNR can be used to improve time resolution, reduce laser power requirements-photodynamic damage, and, in certain cases, detection depth, for MPE imaging techniques. JF - Journal of Microscopy (Oxford) AU - Combs, Christian A AU - Smirnov, Aleksandr V AU - Riley, Jason D AU - Gandjbakhche, Amir H AU - Knutson, Jay R AU - Balaban, Robert S AD - NHLBI Light Microscopy Facility, combsc@nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 330 EP - 337 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 228 IS - 3 SN - 0022-2720, 0022-2720 KW - Biotechnology and Bioengineering Abstracts KW - Brain KW - GFP KW - light collection KW - trans-fluorescence KW - two-photon microscopy KW - Neuroimaging KW - Microscopy KW - Lasers KW - Brain slice preparation KW - Light effects KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20565526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Microscopy+%28Oxford%29&rft.atitle=Optimization+of+multiphoton+excitation+microscopy+by+total+emission+detection+using+a+parabolic+light+reflector&rft.au=Combs%2C+Christian+A%3BSmirnov%2C+Aleksandr+V%3BRiley%2C+Jason+D%3BGandjbakhche%2C+Amir+H%3BKnutson%2C+Jay+R%3BBalaban%2C+Robert+S&rft.aulast=Combs&rft.aufirst=Christian&rft.date=2007-12-01&rft.volume=228&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+Microscopy+%28Oxford%29&rft.issn=00222720&rft_id=info:doi/10.1111%2Fj.1365-2818.2007.01851.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Microscopy; Lasers; Brain slice preparation; Light effects DO - http://dx.doi.org/10.1111/j.1365-2818.2007.01851.x ER - TY - JOUR T1 - Malaria Surveillance Counts AN - 20556949; 8015360 AB - Clinical and epidemiologic surveillance of malaria cases and deaths is required to follow the progress of the reinvigorated malaria control programs nationally and internationally. Current recording, transmittal, analysis, feedback, and use of malaria surveillance information is delayed and imprecise: substantially < 10% of the malaria cases and deaths are being reported. Improvements are occurring, but more emphasis should be placed on prompt, accurate diagnosis, patient management, and recording of clinical manifestations at hospitals. Neurologic signs, severe anemia, metabolic changes, hyperparasitemia, and concurrent sepsis are medical emergencies and require proper clinical and laboratory detection; equipment, reagents, supervision, and certification of laboratorians and clinicians are necessary. Birth weight should also be a major measure of progress in malarial control and overall prenatal care. Although malaria is the most frequent diagnosis at outpatient clinics and hospitals in Africa, co-existing conditions also mandate improved diagnosis, treatment, and registration. Monthly transmittal of information from health units and collation, analysis and feedback through electronic reporting systems using modern information technologies are necessary for resource planning and staff motivation. Denominators to compute rates of illness and death require accurate censuses of communities from which patients come to health units: specialized disease and demographic household surveys designed and performed by nationals are needed to complement hospital-based numerator data. Plasmodium falciparum and P. vivax should be distinguished in the laboratory; the former causes the greatest mortality but the latter is increasingly recognized as a major peril. Because vector control is now a major component of all malaria control programs, there is an urgent need to monitor anopheline sensitivity to insecticides and entomologic inoculation rates. Where interrupting transmission is a goal, parasite rates in groups at greatest risk should be performed. Continual monitoring of plasmodial sensitivity to drugs is necessary using WHO protocols. Human, entomological, and parasitological surveillance must be performed at the same time in the same places and the information shared widely and used for improving control strategies and tactics. These surveillance priorities require training, provision of equipment, supervision, and commitment to sustainability by national authorities and international collaborators and donors. JF - American Journal of Tropical Medicine and Hygiene AU - Breman, J G AU - Holloway, C N AD - Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 36 EP - 47 VL - 77 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Birth weight KW - Parasites KW - Symptoms KW - Human diseases KW - Disease control KW - Malaria KW - Public health KW - Disease transmission KW - Demography KW - Insecticides KW - Feedback KW - Drugs KW - Mortality KW - Data processing KW - Motivation KW - Control programs KW - Anemia KW - Vectors KW - Plasmodium falciparum KW - Sepsis KW - Inoculation KW - Africa KW - National planning KW - Information systems KW - Hospitals KW - K 03400:Human Diseases KW - Q1 08484:Species interactions: parasites and diseases KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Malaria+Surveillance+Counts&rft.au=Breman%2C+J+G%3BHolloway%2C+C+N&rft.aulast=Breman&rft.aufirst=J&rft.date=2007-12-01&rft.volume=77&rft.issue=&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - SuppNotes - Special Issue: Defining and Defeating the Intolerable Burden of Malaria III: Progress and Perspectives. N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Symptoms; Parasites; Human diseases; Disease control; Malaria; Drugs; National planning; Disease transmission; Public health; Birth weight; Mortality; Data processing; Motivation; Control programs; Anemia; Vectors; Demography; Sepsis; Insecticides; Inoculation; Feedback; Hospitals; Information systems; Plasmodium falciparum; Africa ER - TY - JOUR T1 - Mononeme: A new secretory organelle in Plasmodium falciparum merozoites identified by localization of rhomboid-1 protease AN - 20553260; 7937540 AB - Compartmentalization of proteins into subcellular organelles in eukaryotic cells is a fundamental mechanism of regulating complex cellular functions. Many proteins of Plasmodium falciparum merozoites involved in invasion are compartmentalized into apical organelles. We have identified a new merozoite organelle that contains P. falciparum rhomboid-1 (PfROM1), a protease that cleaves the transmembrane regions of proteins involved in invasion. By immunoconfocal microscopy, PfROM1 was localized to a single, thread-like structure on one side of the merozoites that appears to be in close proximity to the subpellicular microtubules. PfROM1 was not found associated with micronemes, rhoptries, or dense granules, the three identified secretory organelles of invasion. Release of merozoites from schizonts resulted in the movement of PfROM1 from the lateral asymmetric localization to the merozoite apical pole and the posterior pole. We have named this single thread-like organelle in merozoites, the mononeme. JF - Proceedings of the National Academy of Sciences, USA AU - Singh, Subhash AU - Plassmeyer, Matthew AU - Gaur, Deepak AU - Miller, Louis H AD - Malaria Cell Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, MD 20852 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 20043 EP - 20048 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 50 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Granules KW - Parasites KW - Microtubules KW - Human diseases KW - Schizonts KW - Malaria KW - Plasmodium falciparum KW - Public health KW - Micronemes KW - Microscopy KW - Merozoites KW - Proteinase KW - Organelles KW - K 03330:Biochemistry KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20553260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Mononeme%3A+A+new+secretory+organelle+in+Plasmodium+falciparum+merozoites+identified+by+localization+of+rhomboid-1+protease&rft.au=Singh%2C+Subhash%3BPlassmeyer%2C+Matthew%3BGaur%2C+Deepak%3BMiller%2C+Louis+H&rft.aulast=Singh&rft.aufirst=Subhash&rft.date=2007-12-01&rft.volume=104&rft.issue=50&rft.spage=20043&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Human diseases; Malaria; Public health; Granules; Microtubules; Micronemes; Microscopy; Schizonts; Proteinase; Merozoites; Organelles; Plasmodium falciparum ER - TY - JOUR T1 - Lifestyle Factors and Incident Mobility Limitation in Obese and Non-obese Older Adults AN - 20536252; 8041718 AB - OBJECTIVE: This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults. RESEARCH METHODS AND PROCEDURES: Data were from men and women, 70 to 79 years of age from Pittsburgh, PA and Memphis, TN, participating in the Health, Aging and Body Composition (Health ABC) study. In addition to individual lifestyle practices, a high-risk lifestyle score (0 to 4) was calculated indicating the total number of unhealthy lifestyle practices per person. Mobility limitation was defined as reported difficulty walking 1/4 mile or climbing 10 steps during two consecutive semiannual assessments over 6.5 years. RESULTS: In non-obese older persons, significant risk factors for incident mobility limitation after adjustment for socio-demographics and health-related variables were current and former smoking [hazard ratio (HR) = 1.51; 95% confidence interval (CI), 1.20 to 1.89; HR = 1.40; 95% CI, 1.12 to 1.74), former alcohol intake (HR = 1.30; 95% CI, 1.05 to 1.60), low and medium physical activity (HR = 1.78; 95% CI, 1.45 to 2.18; HR = 1.29, 95% CI, 1.07 to 1.54), and eating an unhealthy diet (HR = 1.57; 95% CI, 1.17 to 2.10). In the obese, only low physical activity was associated with a significantly increased risk of mobility limitation (HR = 1.44; 95% CI, 1.08 to 1.92). Having two or more unhealthy lifestyle factors was a strong predictor of mobility limitation in the non-obese only (HR = 1.98; 95% CI, 1.61 to 2.43). Overall, obese persons had a significantly higher risk of mobility limitation compared with non-obese persons, independent of lifestyle factors (HR = 1.73; 95% CI, 1.52 to 1.96). CONCLUSIONS: These results underscore the importance of a healthy lifestyle for maintaining function among non-obese older adults. However, a healthy lifestyle cannot overcome the effect of obesity in obese older adults; this stresses the importance of preventing obesity to protect against mobility loss in older persons. JF - Obesity Research AU - Koster, Annemarie AU - Penninx, Brenda WJH AU - Newman, Anne B AU - Visser, Marjolein AU - van Gool, Coen H AU - Harris, Tamara B AU - van Eijk, Jacques ThM AU - Kempen, Gertrudis IJM AU - Brach, Jennifer S AU - Simonsick, Eleanor M AU - Houston, Denise K AU - Tylavsky, Frances A AU - Rubin, Susan M AU - Kritchevsky, Stephen B AD - Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands. Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, Maryland. Clinical Research Branch, National Institute on Aging, Baltimore, Maryland. Department of Psychiatry/Institute for Research in Extramural Medicine Institute, Vrije University Medical Center, Amsterdam, The Netherlands. Department of Epidemiology, Graduate School of Public Health, and. Department of Physical Therapy, University of Pittsburgh, Pittsburgh, Pennsylvania. Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland. Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina. Department of Preventive Medi Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3122 EP - 3132 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 12 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Alcohol KW - Obesity KW - Eating disorders KW - Men KW - Women KW - Gerontology KW - Stress KW - Walking KW - Health KW - Exercise KW - Adults KW - Movement KW - Lifestyle KW - Evaluation KW - Smoking KW - Climbing KW - Risk factors KW - Diet KW - Body composition KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20536252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Lifestyle+Factors+and+Incident+Mobility+Limitation+in+Obese+and+Non-obese+Older+Adults&rft.au=Koster%2C+Annemarie%3BPenninx%2C+Brenda+WJH%3BNewman%2C+Anne+B%3BVisser%2C+Marjolein%3Bvan+Gool%2C+Coen+H%3BHarris%2C+Tamara+B%3Bvan+Eijk%2C+Jacques+ThM%3BKempen%2C+Gertrudis+IJM%3BBrach%2C+Jennifer+S%3BSimonsick%2C+Eleanor+M%3BHouston%2C+Denise+K%3BTylavsky%2C+Frances+A%3BRubin%2C+Susan+M%3BKritchevsky%2C+Stephen+B&rft.aulast=Koster&rft.aufirst=Annemarie&rft.date=2007-12-01&rft.volume=15&rft.issue=12&rft.spage=3122&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-03-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lifestyle; Movement; Obesity; Gerontology; Adults; Health; Exercise; Diet; Alcohol; Smoking; Walking; Stress; Climbing; Women; Men; Risk factors; Body composition; Eating disorders; Evaluation ER - TY - JOUR T1 - A Phase I Trial of Lenalidomide in Patients with Recurrent Primary Central Nervous System Tumors AN - 20531592; 7933796 AB - PURPOSE: Inhibition of angiogenesis represents a promising new therapeutic strategy for treating primary malignant brain tumors. Lenalidomide, a potent analogue of the antiangiogenic agent thalidomide, has shown significant activity in several hematologic malignancies, and therefore we chose to explore its tolerability and activity in patients with primary central nervous system tumors. Experimental Design: A phase I interpatient dose escalation trial of lenalidomide in patients with recurrent primary central nervous system tumors was conducted. RESULTS: Thirty-six patients were accrued to the study, of which 28 were evaluable for toxicity, the primary end point of the trial. We show that lenalidomide can be given safely up to doses of 20 mg/m super(2), with the only toxicity being a probable increased risk of thromboembolic disease. Pharmacokinetic studies reveal good bioavailability, linear kinetics, and no effects of enzyme-inducing antiepileptic drugs on the metabolism of lenalidomide. No objective radiographic responses were seen in any of the treated patients. In the group of 24 patients with recurrent glioblastoma, the median time to tumor progression was <2 months and only 12.5% of patients were progression-free at 6 months. CONCLUSION: Lenalidomide is well tolerated in patients with recurrent glioma in doses up to 20 mg/m super(2). Treatment may be associated with an increased risk of thromboembolic disease. Preliminary data suggest that single agent activity may be limited in patients with recurrent glioblastoma at the doses evaluated although larger studies will be needed to confirm these observations. JF - Clinical Cancer Research AU - Fine, Howard A AU - Kim, Lyndon AU - Albert, Paul S AU - Duic, JPaul AU - Ma, Hilary AU - Zhang, Wei AU - Tohnya, Tanyifor AU - Figg, William D AU - Royce, Cheryl AD - Authors' Affiliations: Neuro-Oncology Branch and Medical Oncology Branch, National Cancer Institute Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7101 EP - 7106 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 23 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Glioblastoma KW - Central nervous system KW - antiangiogenic agents KW - Data processing KW - Thalidomide KW - Angiogenesis KW - Toxicity KW - Clinical trials KW - Pharmacokinetics KW - Thromboembolism KW - Brain tumors KW - Bioavailability KW - Malignancy KW - Kinetics KW - Glioma KW - Antiepileptic agents KW - Metabolism KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20531592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Phase+I+Trial+of+Lenalidomide+in+Patients+with+Recurrent+Primary+Central+Nervous+System+Tumors&rft.au=Fine%2C+Howard+A%3BKim%2C+Lyndon%3BAlbert%2C+Paul+S%3BDuic%2C+JPaul%3BMa%2C+Hilary%3BZhang%2C+Wei%3BTohnya%2C+Tanyifor%3BFigg%2C+William+D%3BRoyce%2C+Cheryl&rft.aulast=Fine&rft.aufirst=Howard&rft.date=2007-12-01&rft.volume=13&rft.issue=23&rft.spage=7101&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Glioblastoma; antiangiogenic agents; Data processing; Thalidomide; Angiogenesis; Toxicity; Clinical trials; Thromboembolism; Pharmacokinetics; Brain tumors; Bioavailability; Malignancy; Kinetics; Glioma; Antiepileptic agents; Metabolism ER - TY - JOUR T1 - Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex AN - 20520298; 8019398 AB - Type II dihydrofolate reductase (DHFR) is a plasmid-encoded enzyme that confers resistance to bacterial DHFR-targeted antifolate drugs. It forms a symmetric homotetramer with a central pore which functions as the active site. Its unusual structure, which results in a promiscuous binding surface that accommodates either the dihydrofolate (DHF) substrate or the NADPH cofactor, has constituted a significant limitation to efforts to understand its substrate specificity and reaction mechanism. We describe here the first structure of a ternary R67 DHFR super(.)DHF super(.)NADP super(+) catalytic complex, resolved to 1.26 Aa. This structure provides the first clear picture of how this enzyme, which lacks the active site carboxyl residue that is ubiquitous in Type I DHFRs, is able to function. In the catalytic complex, the polar backbone atoms of two symmetry-related I68 residues provide recognition motifs that interact with the carboxamide on the nicotinamide ring, and the N3-O4 amide function on the pteridine ring. This set of interactions orients the aromatic rings of substrate and cofactor in a relative endo geometry in which the reactive centers are held in close proximity. Additionally, a central, hydrogen-bonded network consisting of two pairs of Y69-Q67-Q67'-Y69' residues provides an unusually tight interface, which appears to serve as a "molecular clamp" holding the substrates in place in an orientation conducive to hydride transfer. In addition to providing the first clear insight regarding how this extremely unusual enzyme is able to function, the structure of the ternary complex provides general insights into how a mutationally challenged enzyme, i.e., an enzyme whose evolution is restricted to four-residues-at-a-time active site mutations, overcomes this fundamental limitation. JF - Biochemistry (Washington) AU - Krahn, Joseph M AU - Jackson, Michael R AU - DeRose, Eugene F AU - Howell, Elizabeth E AU - London, Robert E AD - Laboratory of Structural Biology, MR-01, National Institute of Environmental Health Sciences, National Institutes of Health, Box 12233, Research Triangle Park, North Carolina 27709 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 14878 EP - 14888 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 46 IS - 51 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology KW - nicotinamide KW - Substrate specificity KW - Enzymes KW - NADP KW - pteridine KW - Pores KW - Reaction mechanisms KW - Cofactors KW - Dihydrofolate reductase KW - Structure-function relationships KW - Crystal structure KW - amides KW - Mutation KW - Evolution KW - Aromatics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20520298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Crystal+Structure+of+a+Type+II+Dihydrofolate+Reductase+Catalytic+Ternary+Complex&rft.au=Krahn%2C+Joseph+M%3BJackson%2C+Michael+R%3BDeRose%2C+Eugene+F%3BHowell%2C+Elizabeth+E%3BLondon%2C+Robert+E&rft.aulast=Krahn&rft.aufirst=Joseph&rft.date=2007-12-01&rft.volume=46&rft.issue=51&rft.spage=14878&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701532rPII%3AS0006-2960%2870%2901532-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - nicotinamide; Enzymes; Substrate specificity; NADP; pteridine; Reaction mechanisms; Pores; Dihydrofolate reductase; Cofactors; Structure-function relationships; Crystal structure; Mutation; amides; Aromatics; Evolution DO - http://dx.doi.org/10.1021/bi701532rPII:S0006-2960(70)01532-5 ER - TY - JOUR T1 - Characterization of the immune response to collagen-like proteins Scl1 and Scl2 of serotype M1 and M28 group A Streptococcus AN - 20503057; 7982468 AB - Group A Streptococcus (GAS) infections may trigger autoimmune sequelae thought to involve streptococcal antibodies cross-reactive to human antigens. Here, the antigenicity of the streptococcal collagen-like (CL) proteins, Scl1 and Scl2, that exhibit structural similarity to human collagen, was analyzed. Antibodies to Scl1.1 protein were detected in human sera from healthy individuals previously infected with M1 GAS and from patients with various GAS infections, as well as in sera from mice infected with M1 GAS. Linear B-cell epitope mapping identified immunoreactive peptides corresponding to the CL region of Scl1.1. Humoral responses to Scl1.28 and Scl2.28 were also detected in pediatric patients and mice infected with M28 GAS. JF - FEMS Microbiology Letters AU - Hoe, Nancy P AU - Lukomska, Ewa AU - Musser, James M AU - Lukomski, Slawomir AD - Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, slukomski@hsc.wvu.edu Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 142 EP - 149 PB - Elsevier Science, P.O. Box 211 VL - 277 IS - 2 SN - 0378-1097, 0378-1097 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - group A Streptococcus KW - Scl KW - humoral response KW - Streptococcus KW - Serotypes KW - Peptide mapping KW - Antigenicity KW - Complications KW - Lymphocytes B KW - Pediatrics KW - Epitope mapping KW - Infection KW - Collagen KW - Antibodies KW - Immune response KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20503057?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEMS+Microbiology+Letters&rft.atitle=Characterization+of+the+immune+response+to+collagen-like+proteins+Scl1+and+Scl2+of+serotype+M1+and+M28+group+A+Streptococcus&rft.au=Hoe%2C+Nancy+P%3BLukomska%2C+Ewa%3BMusser%2C+James+M%3BLukomski%2C+Slawomir&rft.aulast=Hoe&rft.aufirst=Nancy&rft.date=2007-12-01&rft.volume=277&rft.issue=2&rft.spage=142&rft.isbn=&rft.btitle=&rft.title=FEMS+Microbiology+Letters&rft.issn=03781097&rft_id=info:doi/10.1111%2Fj.1574-6968.2007.00955.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Antibodies; Serotypes; Peptide mapping; Pediatrics; Lymphocytes B; Complications; Antigenicity; Epitope mapping; Immune response; Infection; Collagen; Streptococcus DO - http://dx.doi.org/10.1111/j.1574-6968.2007.00955.x ER - TY - JOUR T1 - Advances in fluorescent protein technology AN - 20502248; 7936322 AB - Current fluorescent protein (FP) development strategies are focused on fine-tuning the photophysical properties of blue to yellow variants derived from the Aequorea victoria jellyfish green fluorescent protein (GFP) and on the development of monomeric FPs from other organisms that emit in the yellow-orange to far-red regions of the visible light spectrum. Progress toward these goals has been substantial, and near-infrared emitting FPs may loom over the horizon. The latest efforts in jellyfish variants have resulted in new and improved monomeric BFP, CFP, GFP and YFP variants, and the relentless search for a bright, monomeric and fast-maturing red FP has yielded a host of excellent candidates, although none is yet optimal for all applications. Meanwhile, photoactivatable FPs are emerging as a powerful class of probes for intracellular dynamics and, unexpectedly, as useful tools for the development of superresolution microscopy applications. JF - Journal of Cell Science AU - Shaner, Nathan C AU - Patterson, George H AU - Davidson, Michael W AD - The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development (NICHD), Bethesda, MD 20892, USA. National High Magnetic Field Laboratory and Department of Biological Science, The Florida State University, Tallahassee, FL 32310, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 4247 EP - 4260 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK, [URL:http://www.biologists.com/web/index.html] VL - 120 IS - 24 SN - 0021-9533, 0021-9533 KW - Biotechnology and Bioengineering Abstracts KW - Microscopy KW - Green fluorescent protein KW - Aequorea victoria KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20502248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=Advances+in+fluorescent+protein+technology&rft.au=Shaner%2C+Nathan+C%3BPatterson%2C+George+H%3BDavidson%2C+Michael+W&rft.aulast=Shaner&rft.aufirst=Nathan&rft.date=2007-12-01&rft.volume=120&rft.issue=24&rft.spage=4247&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Microscopy; Green fluorescent protein; Light effects; Aequorea victoria ER - TY - JOUR T1 - Anti-Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts AN - 20498866; 7933805 AB - PURPOSE: To determine the antitumor activity of the anti-mesothelin immunotoxin SS1P in combination with gemcitabine against mesothelin-expressing tumor xenografts. Experimental Design: The in vitro activity of SS1P in combination with gemcitabine against the mesothelin-expressing cell line A431/K5 was evaluated using cytotoxicity and apoptosis assays. The antitumor activity of this combination was evaluated in nude mice bearing A431/K5 tumor xenografts. Tumor-bearing mice were treated with different doses and schedules of gemcitabine alone, SS1P alone (0.2 mg/kg i.v. every other day x three doses), or with both agents together, and tumor volumes were measured over time. RESULTS: In vitro studies failed to show the synergy of SS1P plus gemcitabine against the mesothelin-expressing A431/K5 cells. In contrast, in the in vivo setting, there was a marked synergy when SS1P was combined with gemcitabine for the treatment of mesothelin-expressing tumor xenografts. This synergy was present using different doses and schedules of gemcitabine administration. In mice treated with fractionated doses of gemcitabine in combination with SS1P, complete tumor regression was observed in all mice and was long-lasting in 60% of the animals. Also, this antitumor activity was specific to SS1P because HA22, an immunotoxin targeting CD22 not expressed on A431/K5 cells, did not increase the efficacy of gemcitabine. CONCLUSIONS: SS1P in combination with gemcitabine results in marked antitumor activity against mesothelin-expressing tumors. This combination could be potentially useful for the treatment of human cancers that express mesothelin and are responsive to gemcitabine therapy. JF - Clinical Cancer Research AU - Hassan, Raffit AU - Broaddus, VCourtney AU - Wilson, Shannon AU - Liewehr, David J AU - Zhang, Jingli AD - Authors' Affiliations: Laboratory of Molecular Biology, and Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, and the Clinical Center, NIH, Bethesda, Maryland, and Lung Biology Center, San Francisco General Hospital, University of California, San Francisco, California Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7166 EP - 7171 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 23 SN - 1078-0432, 1078-0432 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - CD22 antigen KW - Cytotoxicity KW - Apoptosis KW - gemcitabine KW - Tumors KW - Xenografts KW - Immunotoxins KW - Cancer KW - Antitumor activity KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20498866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Anti-Mesothelin+Immunotoxin+SS1P+in+Combination+with+Gemcitabine+Results+in+Increased+Activity+against+Mesothelin-Expressing+Tumor+Xenografts&rft.au=Hassan%2C+Raffit%3BBroaddus%2C+VCourtney%3BWilson%2C+Shannon%3BLiewehr%2C+David+J%3BZhang%2C+Jingli&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2007-12-01&rft.volume=13&rft.issue=23&rft.spage=7166&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; CD22 antigen; Apoptosis; gemcitabine; Xenografts; Tumors; Cancer; Immunotoxins; Antitumor activity ER - TY - JOUR T1 - Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA AN - 20468565; 7921519 AB - Methicillin-resistant Staphylococcus aureus (MRSA) remains a major human pathogen. Traditionally, MRSA infections occurred exclusively in hospitals and were limited to immunocompromised patients or individuals with predisposing risk factors. However, recently there has been an alarming epidemic caused by community-associated (CA)-MRSA strains, which can cause severe infections that can result in necrotizing fasciitis or even death in otherwise healthy adults outside of healthcare settings super(2). In the US, CA-MRSA is now the cause of the majority of infections that result in trips to the emergency room super(3). It is unclear what makes CA-MRSA strains more successful in causing human disease compared with their hospital- associated counterparts. Here we describe a class of secreted staphylococcal peptides that have a remarkable ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection. These peptides are produced at high concentrations by standard CA- MRSA strains and contribute significantly to the strains ability to cause disease in animal models of infection. Our study reveals a previously uncharacterized set of S. aureus virulence factors that account at least in part for the enhanced virulence of CA-MRSA. JF - Nature Medicine AU - Wang, Rong AU - Braughton, Kevin R AU - Kretschmer, Dorothee AU - Bach, Thanh-Huy L AU - Queck, Shu Y AU - Li, Min AU - Kennedy, Adam D AU - Dorward, David W AU - Klebanoff, Seymour J AU - Peschel, Andreas AU - DeLeo, Frank R AU - Otto, Michael Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1510 EP - 1514 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 13 IS - 12 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Epidemics KW - virulence factors KW - Drug resistance KW - Animal models KW - Leukocytes (neutrophilic) KW - Pathogens KW - Infection KW - Immunocompromised hosts KW - Necrotizing fasciitis KW - Risk factors KW - Staphylococcus aureus KW - Hospitals KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20468565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Identification+of+novel+cytolytic+peptides+as+key+virulence+determinants+for+community-associated+MRSA&rft.au=Wang%2C+Rong%3BBraughton%2C+Kevin+R%3BKretschmer%2C+Dorothee%3BBach%2C+Thanh-Huy+L%3BQueck%2C+Shu+Y%3BLi%2C+Min%3BKennedy%2C+Adam+D%3BDorward%2C+David+W%3BKlebanoff%2C+Seymour+J%3BPeschel%2C+Andreas%3BDeLeo%2C+Frank+R%3BOtto%2C+Michael&rft.aulast=Wang&rft.aufirst=Rong&rft.date=2007-12-01&rft.volume=13&rft.issue=12&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1656 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epidemics; virulence factors; Risk factors; Necrotizing fasciitis; Immunocompromised hosts; Drug resistance; Leukocytes (neutrophilic); Animal models; Pathogens; Infection; Hospitals; Staphylococcus aureus DO - http://dx.doi.org/10.1038/nm1656 ER - TY - JOUR T1 - TAGster: efficient selection of LD tag SNPs in single or multiple populations AN - 20467736; 7929419 AB - SUMMARY: Genetic association studies increasingly rely on the use of linkage disequilibrium (LD) tag SNPs to reduce genotyping costs. We developed a software package TAGster to select, evaluate and visualize LD tag SNPs both for single and multiple populations. We implement several strategies to improve the efficiency of current LD tag SNP selection algorithms: (1) we modify the tag SNP selection procedure of Carlson et al. to improve selection efficiency and further generalize it to multiple populations. (2) We propose a redundant SNP elimination step to speed up the exhaustive tag SNP search algorithm proposed by Qin et al. (3) We present an additional multiple population tag SNP selection algorithm based on the framework of Howie et al., but using our modified exhaustive search procedure. We evaluate these methods using resequenced candidate gene data from the Environmental Genome Project and show improvements in both computational and tagging efficiency. AVAILABILITY: The software Package TAGster is freely available at http://www.niehs.nih.gov/research/resources/software/tagster/. Supplementary information: Additional information, including a tutorial, detailed algorithm and detailed evaluation results, is also available from TAGster web site (see above). JF - Bioinformatics AU - Xu, Zongli AU - Kaplan, Norman L AU - Taylor, Jack A AD - Epidemiology Branch, Biostatistics Branch and Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA, taylor@niehs.nih.gov Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 3254 EP - 3255 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 23 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Computer programs KW - Linkage disequilibrium KW - software KW - Single-nucleotide polymorphism KW - Genotyping KW - Algorithms KW - Bioinformatics KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20467736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=TAGster%3A+efficient+selection+of+LD+tag+SNPs+in+single+or+multiple+populations&rft.au=Xu%2C+Zongli%3BKaplan%2C+Norman+L%3BTaylor%2C+Jack+A&rft.aulast=Xu&rft.aufirst=Zongli&rft.date=2007-12-01&rft.volume=23&rft.issue=23&rft.spage=3254&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Linkage disequilibrium; Computer programs; software; Single-nucleotide polymorphism; Genotyping; Algorithms; Bioinformatics; Computer applications ER - TY - JOUR T1 - Dynamics of Escherichia coli Chromosome Segregation during Multifork Replication AN - 20467693; 7741951 AB - Slowly growing Escherichia coli cells have a simple cell cycle, with replication and progressive segregation of the chromosome completed before cell division. In rapidly growing cells, initiation of replication occurs before the previous replication rounds are complete. At cell division, the chromosomes contain multiple replication forks and must be segregated while this complex pattern of replication is still ongoing. Here, we show that replication and segregation continue in step, starting at the origin and progressing to the replication terminus. Thus, early-replicated markers on the multiple-branched chromosomes continue to separate soon after replication to form separate protonucleoids, even though they are not segregated into different daughter cells until later generations. The segregation pattern follows the pattern of chromosome replication and does not follow the cell division cycle. No extensive cohesion of sister DNA regions was seen at any growth rate. We conclude that segregation is driven by the progression of the replication forks. JF - Journal of Bacteriology AU - Nielsen, Henrik J AU - Youngren, Brenda AU - Hansen, Flemming G AU - Austin, Stuart AD - Gene Regulation and Chromosome Biology Laboratory, National Cancer Institute, CCR, NCI-Frederick, Frederick, Maryland 21702-1201. Microbial Genomics Group, Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8660 EP - 8666 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Growth rate KW - Chromosomes KW - Cell division KW - Replication initiation KW - Replication forks KW - Cell cycle KW - Escherichia coli KW - DNA KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20467693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Dynamics+of+Escherichia+coli+Chromosome+Segregation+during+Multifork+Replication&rft.au=Nielsen%2C+Henrik+J%3BYoungren%2C+Brenda%3BHansen%2C+Flemming+G%3BAustin%2C+Stuart&rft.aulast=Nielsen&rft.aufirst=Henrik&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8660&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Growth rate; Cell division; Chromosomes; Replication initiation; Replication forks; Cell cycle; DNA; Escherichia coli ER - TY - JOUR T1 - Vulnerability of the Orbitofrontal Cortex to Age-Associated Structural and Functional Brain Changes AN - 20464168; 9151047 AB - Abstract:Cross-sectional and longitudinal findings from the Baltimore Longitudinal Study of Aging (BLSA) neuroimaging study indicate that the orbitofrontal cortex (OFC) is among those regions vulnerable to age-associated tissue loss in older adults without dementia. Neuropathologic and recent in vivo amyloid imaging studies indicate that the OFC is also among the earliest neocortical regions to show deposition of amyloid plaques in aging and Alzheimer's disease. We performed behavioral and imaging studies to investigate age effects on specific aspects of OFC function. We compared performance in young (age 20-40) and old (age 60 and older) adults on cognitive tasks selected for differential sensitivity to OFC versus dorsolateral prefrontal cortex (DLPFC). Overall, greater age differences were seen in the OFC tasks compared to DLPFC tasks, with Delayed Match and Non-Match to Sample tasks showing the greatest effect size among OFC tasks and Self-Ordered Pointing Task showing the greatest effect size among DLPFC tasks. A functional magnetic resonance imaging study was conducted in parallel to probe the neural underpinnings of age differences in OFC function using the Delayed Match and Non-Match to Sample paradigm. Young but not old adults showed the expected OFC activation. Older compared with young adults showed greater activation in association with successful performance for several posterior regions, perhaps indicating compensation in the face of OFC deficits. Together, these findings indicate a vulnerability of the OFC to age-related decline in brain structure and function. Future studies using new in vivo imaging probes will help determine whether neuropathologic changes underlie the structural and functional changes. JF - Annals of the New York Academy of Sciences AU - Resnick, Susan M AU - Lamar, Melissa AU - Driscoll, Ira AD - aIntramural Research Program, National Institute on Aging, Gerontology Research Center, Baltimore, Maryland 21224, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 562 EP - 575 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 1121 IS - 1 SN - 0077-8923, 0077-8923 KW - CSA Neurosciences Abstracts; Risk Abstracts KW - orbitofrontal cortex KW - aging KW - cognition KW - MRI KW - longitudinal studies KW - Brain mapping KW - Neuroimaging KW - Age KW - Functional magnetic resonance imaging KW - Aging KW - Alzheimer's disease KW - Probes KW - USA, Maryland, Baltimore KW - young adults KW - Age differences KW - Cortex KW - Structure-function relationships KW - Dementia disorders KW - Geriatrics KW - Plaques KW - Sensitivity KW - Brain KW - Functional anatomy KW - Neurodegenerative diseases KW - Cognitive ability KW - Computed tomography KW - vulnerability KW - Cortex (prefrontal) KW - Amyloid KW - N3 11001:Behavioral and Cognitive Neuroscience KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20464168?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Vulnerability+of+the+Orbitofrontal+Cortex+to+Age-Associated+Structural+and+Functional+Brain+Changes&rft.au=Resnick%2C+Susan+M%3BLamar%2C+Melissa%3BDriscoll%2C+Ira&rft.aulast=Resnick&rft.aufirst=Susan&rft.date=2007-12-01&rft.volume=1121&rft.issue=1&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1401.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Brain mapping; Age; Neuroimaging; Functional magnetic resonance imaging; Alzheimer's disease; Aging; Probes; Functional anatomy; Age differences; Neurodegenerative diseases; Cortex; Structure-function relationships; Cognitive ability; Computed tomography; Dementia disorders; Geriatrics; Plaques; Cortex (prefrontal); Amyloid; Sensitivity; Brain; vulnerability; young adults; longitudinal studies; aging; USA, Maryland, Baltimore DO - http://dx.doi.org/10.1196/annals.1401.027 ER - TY - JOUR T1 - TOM1L1 Is a Lyn Substrate Involved in Fc epsilon RI Signaling in Mast Cells AN - 20455649; 7935177 AB - Protein-tyrosine kinase Lyn and Syk are critical for antigen-receptor-induced signal transduction in mast cells. To identify novel Lyn/Syk substrates, we screened an RBL-2H3 bacterial expression library for proteins that were tyrosine phosphorylated with baculoviral expressed Lyn or Syk. Five clones as potential Lyn substrates and eight clones as Syk substrates were identified including known substrates such as SLP-76, LAT, and alpha -tubulin. A potential substrate of Lyn identified was the molecule TOM1L1, which has several domains thought to be important for membrane trafficking and protein-protein interactions. Because the function of TOM1L1 is unclear, the rat TOM1L1 full-length cDNA was isolated and used to express the protein in COS-1 and RBL-2H3 mast cells. In COS-1 cells, the co-transfection of TOM1L1 and Lyn, but not Syk, resulted in the tyrosine phosphorylation of TOM1L1. In RBL-2H3 mast cells, the overexpressed TOM1L1 was strongly tyrosine phosphorylated in non-stimulated cells, and this phosphorylation was enhanced by Fc epsilon RI aggregation. By subcellular fractionation, wild-type TOM1L1 was mainly in the cytoplasm with a small fraction constitutively associated with the membrane; this association was markedly reduced in deletion mutants lacking several of the protein interaction domains. The overexpression of TOM1L1 enhanced antigen-induced tumor necrosis factor (TNF) alpha generation and release. Both protein interaction domains (VHS and the coiled-coil domains) were required for the increased TNF alpha release, but not the increased TNF alpha generation. These results suggest that TOM1L1 is a novel protein involved in the Fc epsilon RI signal transduction for the generation of cytokines. JF - Journal of Biological Chemistry AU - Zhang, Juan AU - Suzuki, Katsuhiro AU - Hitomi, Tomohiro AU - Siraganian, Reuben P AD - Receptors and Signal Transduction Section, Oral Infection and Immunity Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37669 EP - 37677 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 52 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Deletion mutant KW - double prime Fc receptors KW - SLP-76 protein KW - Tumor necrosis factor KW - Mast cells KW - Tyrosine KW - Syk protein KW - Phosphorylation KW - Cytoplasm KW - Protein-tyrosine kinase KW - membrane trafficking KW - Cytokines KW - Tumor necrosis factor- alpha KW - Tubulin KW - Protein interaction KW - Lyn protein KW - Signal transduction KW - J 02320:Cell Biology KW - F 06960:Molecular Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=TOM1L1+Is+a+Lyn+Substrate+Involved+in+Fc+epsilon+RI+Signaling+in+Mast+Cells&rft.au=Zhang%2C+Juan%3BSuzuki%2C+Katsuhiro%3BHitomi%2C+Tomohiro%3BSiraganian%2C+Reuben+P&rft.aulast=Zhang&rft.aufirst=Juan&rft.date=2007-12-01&rft.volume=282&rft.issue=52&rft.spage=37669&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Deletion mutant; double prime Fc receptors; Tumor necrosis factor; SLP-76 protein; Tyrosine; Mast cells; Syk protein; Phosphorylation; Cytoplasm; Protein-tyrosine kinase; membrane trafficking; Cytokines; Tumor necrosis factor- alpha; Tubulin; Lyn protein; Protein interaction; Signal transduction ER - TY - JOUR T1 - Human Islet-Derived Precursor Cells Are Mesenchymal Stromal Cells That Differentiate and Mature to Hormone-Expressing Cells In Vivo AN - 20451271; 7938055 AB - Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise for cell therapy because they can expand before differentiation to produce a large supply of functional insulin-producing cells. Previously, we described proliferative populations of human islet-derived precursor cells (hIPCs) from adult islets. To show the differentiation potential of hIPCs, which do not express insulin mRNA after at least 1,000-fold expansion, we generated epithelial cell clusters (ECCs) during 4 days of differentiation in vitro. After transplantation into mice, 22 of 35 ECC preparations differentiated and matured into functional cells that secreted human C-peptide in response to glucose. Transcripts for insulin, glucagon, and somatostatin in recovered ECC grafts increased with time in vivo, reaching levels approximately 1% of those in adult islets. We show that hIPCs are mesenchymal stromal cells (MSCs) that adhere to plastic, express CD73, CD90, and CD105, and can differentiate in vitro into adipocytes, chondrocytes, and osteocytes. Moreover, we find a minor population of CD105 super(+)/CD73 super(+)/CD90 super(+) cells in adult human islets (prior to incubation in vitro) that express insulin mRNA at low levels. We conclude that hIPCs are a specific type of pancreas-derived MSC that are capable of differentiating into hormone-expressing cells. Their ability to mature into functional insulin-secreting cells in vivo identifies them as an important adult precursor or stem cell population that could offer a virtually unlimited supply of human islet-like cells for replacement therapy in type 1 diabetes. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Davani, Behrous AU - Ikonomou, Laertis AU - Raaka, Bruce M AU - Geras-Raaka, Elizabeth AU - Morton, Russell A AU - Marcus-Samuels, Bernice AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3215 EP - 3222 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Donors KW - CD105 antigen KW - stromal cells KW - Pancreas KW - Glucagon KW - Glucose KW - Chondrocytes KW - Islets of Langerhans KW - Homeostasis KW - Osteocytes KW - Insulin KW - Somatostatin KW - Diabetes mellitus KW - Differentiation KW - Stem cells KW - CD90 antigen KW - Adipocytes KW - Allografts KW - CD73 antigen KW - Pancreatic islet transplantation KW - Plastics KW - Mesenchyme KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Human+Islet-Derived+Precursor+Cells+Are+Mesenchymal+Stromal+Cells+That+Differentiate+and+Mature+to+Hormone-Expressing+Cells+In+Vivo&rft.au=Davani%2C+Behrous%3BIkonomou%2C+Laertis%3BRaaka%2C+Bruce+M%3BGeras-Raaka%2C+Elizabeth%3BMorton%2C+Russell+A%3BMarcus-Samuels%2C+Bernice%3BGershengorn%2C+Marvin+C&rft.aulast=Davani&rft.aufirst=Behrous&rft.date=2007-12-01&rft.volume=25&rft.issue=12&rft.spage=3215&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Donors; CD105 antigen; stromal cells; Glucagon; Pancreas; Glucose; Chondrocytes; Islets of Langerhans; Homeostasis; Osteocytes; Somatostatin; Insulin; Diabetes mellitus; Differentiation; Stem cells; Adipocytes; CD90 antigen; Allografts; Plastics; Pancreatic islet transplantation; CD73 antigen; Mesenchyme ER - TY - JOUR T1 - CT Colonography with Computer-aided Detection as a Second Reader: Observer Performance Study AN - 20451132; 7937808 AB - PURPOSE: To evaluate the effect of computer-aided detection (CAD) as second reader on radiologists' diagnostic performance in interpreting computed tomographic (CT) colonographic examinations by using a primary two-dimensional (2D) approach, with segmental, unblinded optical colonoscopy as the reference standard. MATERIALS AND METHODS: This HIPAA-compliant study was IRB-approved with written informed consent. Four board-certified radiologists analyzed 60 CT examinations with a commercially available review system. Two-dimensional transverse views were used for initial polyp detection, while three-dimensional (3D) endoluminal and 2D multiplanar views were available for problem solving. After initial review without CAD, the reader was shown CAD-identified polyp candidates. The readers were then allowed to add to or modify their original diagnoses. Polyp location, CT Colonography Reporting and Data System categorization, and reader confidence as to the likelihood of a candidate being a polyp were recorded before and after CAD reading. The area under the receiver operating characteristic (ROC) curve (AUC), sensitivity, and specificity were estimated for CT examinations with and without CAD readings by using multireader multicase analysis. RESULTS: Use of CAD led to nonsignificant average reader AUC increases of 0.03, 0.03, and 0.04 for patients with adenomatous polyps 6 mm or larger, 6-9 mm, and 10 mm or larger, respectively (P greater than or equal to .25); likewise, CAD increased average reader sensitivity by 0.15, 0.16, and 0.14 for those respective groups, with a corresponding decrease in specificity of 0.14. These changes achieved significance for the 6 mm or larger group (P .16). The average reading time was 5.1 minutes plus or minus 3.4 (standard deviation) without CAD. CAD added an average of 3.1 minutes plus or minus 4.3 (62%) to each reading (supine and prone positions combined); average total reading time, 8.2 minutes plus or minus 5.8. CONCLUSION: Use of CAD led to a significant increase in sensitivity for detecting polyps in the 6 mm or larger and 6-9 mm groups at the expense of a similar significant reduction in specificity. [copy ] RSNA, 2007 JF - Radiology AU - Petrick, Nicholas AU - Haider, Maruf AU - Summers, Ronald M AU - Yeshwant, Srinath C AU - Brown, Linda AU - Iuliano, Edward M AU - Louie, Adeline AU - Choi, JRichard AU - Pickhardt, Perry J AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C351, Bethesda, MD 20892-1182 (M.H., R.M.S., S.C.Y., L.B., A.L.) Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 148 EP - 156 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 246 IS - 1 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Standard deviation KW - Computed tomography KW - Problem solving KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=CT+Colonography+with+Computer-aided+Detection+as+a+Second+Reader%3A+Observer+Performance+Study&rft.au=Petrick%2C+Nicholas%3BHaider%2C+Maruf%3BSummers%2C+Ronald+M%3BYeshwant%2C+Srinath+C%3BBrown%2C+Linda%3BIuliano%2C+Edward+M%3BLouie%2C+Adeline%3BChoi%2C+JRichard%3BPickhardt%2C+Perry+J&rft.aulast=Petrick&rft.aufirst=Nicholas&rft.date=2007-12-01&rft.volume=246&rft.issue=1&rft.spage=148&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Standard deviation; Computed tomography; Problem solving; Polyps ER - TY - JOUR T1 - New inhibitors of ABCG2 identified by high-throughput screening AN - 20446894; 7936729 AB - In order to identify novel inhibitors of the ATP-binding cassette transporter, ABCG2, a high-throughput assay measuring the accumulation of the ABCG2 substrate pheophorbide a in ABCG2-overexpressing NCI-H460 MX20 cells was used to screen libraries of compounds. Out of a library of 7,325 natural products and synthetic compounds from the National Cancer Institute/Developmental Therapeutics Program collection, 18 were found to inhibit ABCG2 at 10 mu mol/L. After eliminating flavonoids and compounds of limited availability from the 18 original compounds, 10 of the 11 remaining compounds reversed mitoxantrone resistance in NCI-H460/MX20 cells and prevented ABCG2-mediated BODIPY-prazosin transport in ABCG2-transfected HEK293 cells, confirming an interaction with ABCG2. Based on the activity profiles and the availability of materials, five inhibitors were examined for their ability to compete with [ super(125)I]iodoarylazidoprazosin labeling of ABCG2, increase binding of the anti-ABCG2 antibody 5D3, and prevent P-glycoprotein or multidrug resistance protein 1-mediated transport. At a concentration of 20 mu mol/L, all of the compounds reduced iodoarylazidoprazosin labeling by 50% to 80% compared with controls. All five compounds also increased 5D3 labeling of ABCG2, indicating that these compounds are inhibitors but not substrates of ABCG2. None of the compounds affected P-glycoprotein-mediated rhodamine 123 transport, whereas three affected multidrug resistance protein-1-mediated calcein transport at 25 mu mol/L, suggesting that the compounds are relatively specific for ABCG2. These five novel inhibitors of ABCG2 activity may provide a basis for further investigation of ABCG2 function and its relevance in multidrug resistance. [Mol Cancer Ther 2007; 6(12):3271-8] JF - Molecular Cancer Therapeutics AU - Henrich, Curtis J AU - Robey, Robert W AU - Bokesch, Heidi R AU - Bates, Susan E AU - Shukla, Suneet AU - Ambudkar, Suresh V AU - Dean, Michael AU - McMahon, James B AD - Basic Research Program, SAIC-Frederick, Inc., Molecular Targets Development Program, and Laboratory of Genomic Diversity, NCI Frederick, Frederick, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3271 EP - 3278 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biotechnology Research Abstracts (through 1992) KW - Protein transport KW - Flavonoids KW - Calcein KW - natural products KW - Cancer KW - Antibodies KW - P-Glycoprotein KW - ATP-binding protein KW - high-throughput screening KW - Multidrug resistance KW - rhodamine KW - mitoxantrone KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20446894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=New+inhibitors+of+ABCG2+identified+by+high-throughput+screening&rft.au=Henrich%2C+Curtis+J%3BRobey%2C+Robert+W%3BBokesch%2C+Heidi+R%3BBates%2C+Susan+E%3BShukla%2C+Suneet%3BAmbudkar%2C+Suresh+V%3BDean%2C+Michael%3BMcMahon%2C+James+B&rft.aulast=Henrich&rft.aufirst=Curtis&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3271&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Multidrug resistance; mitoxantrone; natural products; P-Glycoprotein; Antibodies; Flavonoids; Calcein; Cancer; ATP-binding protein; rhodamine; high-throughput screening; Protein transport ER - TY - JOUR T1 - Evaluation of a Novel PCR-Based Assay for Detection and Identification of Chlamydia trachomatis Serovars in Cervical Specimens AN - 20441682; 7935566 AB - The aims of this study were to compare a novel PCR-based Chlamydia trachomatis detection and genotyping (Ct-DT) assay with the FDA-approved, commercially available C. trachomatis detection Hybrid Capture 2 (HC2) assay and to investigate the C. trachomatis serovar distribution among young women in a rural Costa Rican study population. A total of 5,828 sexually active women participating in a community-based trial in Costa Rica were tested for C. trachomatis by HC2. A sample of 1,229 specimens consisting of 100% HC2 C. trachomatis-positive specimens (n = 827) and a random sample of 8% HC2 C. trachomatis-negative specimens (n = 402) were tested with the Ct-DT assay. Agreement between the two assays was determined by the unweighted kappa statistic. Discrepant specimens were tested with a second commercially available test (COBAS TaqMan). The Ct-DT-positive specimens were further analyzed with the Ct-DT genotyping step to investigate the distribution of 14 different C. trachomatis serovars (A, B/Ba, C, D/Da, E, F, G/Ga, H, I/Ia, J, K, L1, L2/L2a, and L3). After accounting for the sampling fraction selected for Ct-DT testing, crude agreement with the HC2 assay was 98% and the kappa was 0.92 (95% confidence interval [CI], 0.89 to 0.97). The 33 discordant samples that were further analyzed with the COBAS TaqMan test showed better agreement with the Ct-DT assay (31/33, P < 0.001). Among the 806 Ct-DT-positive samples, serovar E was the most common serovar (31%), followed by serovars F and D (both 21%) and serovar I (15%). In conclusion, the novel Ct-DT assay permits reliable detection and identification of C. trachomatis serovars. JF - Journal of Clinical Microbiology AU - Quint, Koen AU - Porras, Carolina AU - Safaeian, Mahboobeh AU - Gonzalez, Paula AU - Hildesheim, Allan AU - Quint, Wim AU - van Doorn, Leen-Jan AU - Silva, Sandra AU - Melchers, Willem AU - Schiffman, Mark AU - Rodriguez, Ana Cecilia AU - Wacholder, Sholom AU - Freer, Enrique AU - Cortes, Bernal AU - Herrero, Rolando AD - DDL Diagnostic Laboratory, Voorburg, The Netherlands. Proyecto Epidemiologico Guanacaste, Fundacion INCIENSA, San Jose, Costa Rica. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland. Centro de Investigacion Estructuras Microscopicas, Universidad de Costa Rica, San Jose, Costa Rica. Department of Medical Microbiology, Medical Centre, Radboud University Nijmegen, Nijmegen, The Netherlands Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3986 EP - 3991 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 45 IS - 12 SN - 0095-1137, 0095-1137 KW - Microbiology Abstracts B: Bacteriology KW - Genotyping KW - Hybrids KW - Chlamydia trachomatis KW - Population studies KW - Sampling KW - Clinical trials KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20441682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Evaluation+of+a+Novel+PCR-Based+Assay+for+Detection+and+Identification+of+Chlamydia+trachomatis+Serovars+in+Cervical+Specimens&rft.au=Quint%2C+Koen%3BPorras%2C+Carolina%3BSafaeian%2C+Mahboobeh%3BGonzalez%2C+Paula%3BHildesheim%2C+Allan%3BQuint%2C+Wim%3Bvan+Doorn%2C+Leen-Jan%3BSilva%2C+Sandra%3BMelchers%2C+Willem%3BSchiffman%2C+Mark%3BRodriguez%2C+Ana+Cecilia%3BWacholder%2C+Sholom%3BFreer%2C+Enrique%3BCortes%2C+Bernal%3BHerrero%2C+Rolando&rft.aulast=Quint&rft.aufirst=Koen&rft.date=2007-12-01&rft.volume=45&rft.issue=12&rft.spage=3986&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Hybrids; Genotyping; Population studies; Sampling; Clinical trials; Chlamydia trachomatis ER - TY - JOUR T1 - Variations in Phytoestrogen Content between Different Mill Dates of the Same Diet Produces Significant Differences in the Time of Vaginal Opening in CD-1 Mice and F344 Rats but Not in CD Sprague-Dawley Rats AN - 20418814; 7828246 AB - BACKGROUND: The optimum test diet and rodent species/strain for evaluating endocrine-disrupting compounds (EDCs) are critical. Objectives: We conducted studies to evaluate rodent species sensitivity and the effects of diets varying in phytoestrogen content on the time of vaginal opening (VO) in CD-1 mice, Fischer 344 (F344) rats, and CD Sprague-Dawley (S-D) rats. METHODS: Mice were weaned on postnatal day (PND) 15 and rats on PND 19 and randomly assigned to control or test diets. Body weights, food consumption, and time of VO were recorded. RESULTS: The time of VO was significantly advanced in F344 rats fed diets containing daidzein and genistein, whereas these same diets did not advance VO in S-D rats. When animals were fed the AIN-76A diet spiked with genistein, time of VO was significantly advanced at all doses in CD-1 mice, at the two highest doses in F344 rats, and at the highest dose in S-D rats. The time of VO in F344 rats was more highly correlated with the phytoestrogen content than with the total metaboliz-able energy (ME) of 12 diets. CONCLUSIONS: The S-D rat is less sensitive to dietary phytoestrogens compared with the F344 rat or the CD-1 mouse, suggesting that the S-D rat is not the ideal model for evaluating estrogenic activity of EDCs. The profound effects of dietary phytoestrogens on the time of VO, an estrogen-sensitive marker, indicate that a standardized open-formula phytoestrogen-free diet containing a low ME level should be used to optimize the sensitivity of estrogenic bioassays. JF - Environmental Health Perspectives AU - Thigpen, JE AU - Setchell, KDR AU - Padilla-Banks, E AU - Haseman, J K AU - Saunders, HE AU - Caviness, G F AU - Kissling, GE AU - Grant, M G AU - Forsythe, D B AD - Quality Assurance Laboratory, Comparative Medicine Branch, National Institute of Environmental Health Sciences, P.O.Box 12233, Mail Drop C1-06, Research Triangle Park, NC 27709 USA, thigpen@niehs.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1717 EP - 1726 VL - 115 IS - 12 SN - 0091-6765, 0091-6765 KW - Toxicology Abstracts KW - Diets KW - Food consumption KW - Nutrient deficiency KW - Body weight KW - Endocrine disruptors KW - Energy KW - Vagina KW - Phytoestrogens KW - estrogenic activity KW - Genistein KW - daidzein KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20418814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Variations+in+Phytoestrogen+Content+between+Different+Mill+Dates+of+the+Same+Diet+Produces+Significant+Differences+in+the+Time+of+Vaginal+Opening+in+CD-1+Mice+and+F344+Rats+but+Not+in+CD+Sprague-Dawley+Rats&rft.au=Thigpen%2C+JE%3BSetchell%2C+KDR%3BPadilla-Banks%2C+E%3BHaseman%2C+J+K%3BSaunders%2C+HE%3BCaviness%2C+G+F%3BKissling%2C+GE%3BGrant%2C+M+G%3BForsythe%2C+D+B&rft.aulast=Thigpen&rft.aufirst=JE&rft.date=2007-12-01&rft.volume=115&rft.issue=12&rft.spage=1717&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.10165 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diets; Food consumption; Nutrient deficiency; Body weight; Energy; Endocrine disruptors; Vagina; Phytoestrogens; estrogenic activity; Genistein; daidzein DO - http://dx.doi.org/10.1289/ehp.10165 ER - TY - JOUR T1 - A Monoclonal Fab Derived from a Human Nonimmune Phage Library Reveals a New Epitope on gp41 and Neutralizes Diverse Human Immunodeficiency Virus Type 1 Strains AN - 20375725; 7744185 AB - A monoclonal Fab (Fab 3674) selected from a human nonimmune phage library by panning against the chimeric construct N sub(CCG)-gp41 (which comprises an exposed coiled-coil trimer of gp41 N helices fused in the helical phase onto the minimal thermostable ectodomain of gp41) is described. Fab 3674 is shown to neutralize diverse laboratory-adapted B strains of human immunodeficiency virus type 1 (HIV-1) and primary isolates of subtypes A, B, and C in an Env-pseudotyped-virus neutralization assay, albeit with reduced potency (approximately 25-fold) compared to that of 2F5 and 4E10. Alanine scanning mutagenesis maps a novel epitope to a shallow groove on the N helices of gp41 that is exposed between two C helices in the fusogenic six-helix bundle conformation of gp41. Bivalent Fab 3674 and the C34 peptide (a potent fusion inhibitor derived from the C helix of gp41) are shown to act at similar stages of the fusion reaction and to neutralize HIV-1 synergistically, providing additional evidence that the epitope of Fab 3674 is new and distinct from the binding site of C34. JF - Journal of Virology AU - Gustchina, Elena AU - Louis, John M AU - Lam, Son N AU - Bewley, Carole A AU - Clore, GMarius AD - Laboratories of Chemical Physics. Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 12946 EP - 12953 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 23 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Phages KW - Human immunodeficiency virus 1 KW - Epitopes KW - glycoprotein gp41 KW - Panning KW - Scanning mutagenesis KW - Fab KW - Conformation KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20375725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=A+Monoclonal+Fab+Derived+from+a+Human+Nonimmune+Phage+Library+Reveals+a+New+Epitope+on+gp41+and+Neutralizes+Diverse+Human+Immunodeficiency+Virus+Type+1+Strains&rft.au=Gustchina%2C+Elena%3BLouis%2C+John+M%3BLam%2C+Son+N%3BBewley%2C+Carole+A%3BClore%2C+GMarius&rft.aulast=Gustchina&rft.aufirst=Elena&rft.date=2007-12-01&rft.volume=81&rft.issue=23&rft.spage=12946&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; glycoprotein gp41; Fab; Epitopes; Phages; Panning; Conformation; Scanning mutagenesis ER - TY - JOUR T1 - Replicating and non-replicating viral vectors for vaccine development AN - 20264575; 8853250 AB - Viral vectors provide a convenient means to deliver vaccine antigens to select target cells or tissues. A broad spectrum of replicating and non- replicating vectors is available. An appropriate choice for select applications will depend on the biology of the infectious agent targeted, as well as factors such as whether the vaccine is intended to prevent infection or boost immunity in already infected individuals, prior exposure of the target population to the vector, safety, and the number and size of gene inserts needed. Here several viral vectors under development as HIV/AIDS vaccines are reviewed. A vaccine strategy based on initial priming with a replicating vector to enlist the innate immune system, target mucosal inductive sites, and prime both cellular and humoral systemic and mucosal immune responses is proposed. Subsequently, boosting with a replicating or non-replicating vector and/or protein subunits could lead to induction of necessary levels of protective immunity. JF - Current Opinion in Biotechnology AU - Robert-Guroff, Marjorie AD - National Institutes of Health, National Cancer Institute, Vaccine Branch, 41 Medlars Drive, Building 41, Room D804, Bethesda, MD 20892-5065, United States, guroffm@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 546 EP - 556 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 18 IS - 6 SN - 0958-1669, 0958-1669 KW - Virology & AIDS Abstracts; Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Acquired immune deficiency syndrome KW - Mucosal immunity KW - Human immunodeficiency virus KW - Reviews KW - Vaccines KW - Immunity KW - Infection KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20264575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Replicating+and+non-replicating+viral+vectors+for+vaccine+development&rft.au=Robert-Guroff%2C+Marjorie&rft.aulast=Robert-Guroff&rft.aufirst=Marjorie&rft.date=2007-12-01&rft.volume=18&rft.issue=6&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2007.10.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Acquired immune deficiency syndrome; Mucosal immunity; Reviews; Immunity; Vaccines; Infection; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.copbio.2007.10.010 ER - TY - JOUR T1 - Visualization and experimental analysis of blood vessel formation using transgenic zebrafish AN - 20256881; 8891551 AB - The mechanisms of blood vessel formation have become a subject of enormous scientific and clinical interest. However, it is difficult to visualize the developing vasculature in most living animals due to the ubiquitous and deep localization of vessels within other tissues. The establishment of vascular-specific transgenic zebrafish with fluorescently tagged blood vessels has facilitated high-resolution imaging studies of developing blood and lymphatic vessels in vivo. Use of these transgenic lines for genetic and chemical screening, experimental manipulations, and time-lapse imaging has extended our knowledge of how complex networks of vessels assemble in vivo. Birth Defects Research (Part C) 81:286-296, 2007. Published 2008 Wiley-Liss, Inc. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Cha, Young Ryun AU - Weinstein, Brant M AD - Laboratory of Molecular Genetics, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, WeinsteB@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 286 EP - 296 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 81 IS - 4 SN - 1542-975X, 1542-975X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Danio rerio KW - Blood vessels KW - Congenital defects KW - Embryos KW - imaging KW - Lymphatic system KW - W 30910:Imaging KW - G 07840:Fish UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20256881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Visualization+and+experimental+analysis+of+blood+vessel+formation+using+transgenic+zebrafish&rft.au=Cha%2C+Young+Ryun%3BWeinstein%2C+Brant+M&rft.aulast=Cha&rft.aufirst=Young&rft.date=2007-12-01&rft.volume=81&rft.issue=4&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20103 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-02-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Blood vessels; Congenital defects; Embryos; imaging; Lymphatic system; Danio rerio DO - http://dx.doi.org/10.1002/bdrc.20103 ER - TY - JOUR T1 - Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells AN - 20194848; 7786172 AB - The advent of hybridoma technology has made it possible to study in-depth individual antibody molecules. These studies have revealed a number of surprises that have and are continuing to change our view of the immune system. None of these was more surprising than the demonstration that many antibody molecules are polyreactive - that is they can bind to a variety of different and structurally unrelated self- and non-self-foreign antigens. These findings make it clear that self-reactivity is a common and not necessarily forbidden or pathogenic feature of the immune system and that the well-known broad antibacterial activity of natural antibodies is largely due to polyreactive antibodies. In this brief review we will discuss these insights and their impact on basic and clinical immunology. JF - Journal of Autoimmunity AU - Zhou, Z H AU - Tzioufas, A G AU - Notkins, AL AD - Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 106, 30 Convent Dr., MSC 4322, Bethesda, MD 20892-4322, USA, anotkins@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 219 EP - 228 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 29 IS - 4 SN - 0896-8411, 0896-8411 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Hybridoma KW - Antibodies KW - Antibacterial activity KW - Lymphocytes B KW - Immune system KW - Reviews KW - F 06930:Autoimmunity KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20194848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autoimmunity&rft.atitle=Properties+and+function+of+polyreactive+antibodies+and+polyreactive+antigen-binding+B+cells&rft.au=Zhou%2C+Z+H%3BTzioufas%2C+A+G%3BNotkins%2C+AL&rft.aulast=Zhou&rft.aufirst=Z&rft.date=2007-12-01&rft.volume=29&rft.issue=4&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autoimmunity&rft.issn=08968411&rft_id=info:doi/10.1016%2Fj.jaut.2007.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hybridoma; Antibodies; Antibacterial activity; Lymphocytes B; Reviews; Immune system DO - http://dx.doi.org/10.1016/j.jaut.2007.07.015 ER - TY - JOUR T1 - Effect of Sexually Transmitted Disease (STD) Coinfections on Performance of Three Commercially Available Immunosorbent Assays Used for Detection of Herpes Simplex Virus Type 2-Specific Antibody in Men Attending Baltimore, Maryland, STD Clinics AN - 20100447; 7933543 AB - Two hundred seventy-nine serum samples from men attending sexually transmitted disease (STD) clinics in Baltimore, Maryland, were tested for herpes simplex virus type 2 (HSV-2)-specific antibody by three immunosorbent glycoprotein G-2-based assays (the Kalon, Focus, and Biokit assays). The results for all samples with positive results were confirmed by Western blotting (91/279; 32.6% HSV-2 seroprevalence). All patients were also tested for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma genitalium, human immunodeficiency virus type 1, and hepatitis C virus. The Kalon assay performed very well with samples from this population (90.8% sensitive, 99.4% specific), whereas the Focus assay had a sensitivity (82.6%) much lower than that shown previously. For 19.7% of the samples, the Biokit assay gave an indeterminate result. It was found that the odds of a sample having a Biokit assay indeterminate result compared to that of having a definitive positive or negative results were 3.88 times greater for subjects concurrently infected with N. gonorrhoeae, after the effects of other STDs were controlled for (P = 0.001; 95% confidence interval, 1.78, 8.45). Unfortunately, we were unable to control for HSV-1 infection status in the regression model, which, on the basis of chi super(2) analysis, might also affect the clarity of the Biokit test. The recommended index cutoff value of 1.1 for the Focus and Kalon assays was found to be optimal for this population. JF - Clinical and Vaccine Immunology AU - Summerton, Jean AU - Riedesel, Melissa AU - Laeyendecker, Oliver AU - Gaydos, Charlotte AU - Maldeis, Nancy E AU - Hardick, Andrew AU - Morrow, Rhoda Ashley AU - Quinn, Thomas C AD - The Johns Hopkins University, School of Medicine, Division of Infectious Diseases, Baltimore, Maryland. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, Maryland. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Department of Laboratory Medicine, University of Washington, Seattle, Washington Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1545 EP - 1549 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 14 IS - 12 SN - 1556-6811, 1556-6811 KW - HIV-1 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Western blotting KW - Trichomonas vaginalis KW - Sexually-transmitted diseases KW - Mycoplasma genitalium KW - Herpes simplex virus 1 KW - Chlamydia trachomatis KW - Herpes simplex virus 2 KW - Infection KW - Neisseria gonorrhoeae KW - Immunosorbents KW - Models KW - Antibodies KW - Hepatitis C virus KW - Human immunodeficiency virus 1 KW - Regression analysis KW - Glycoproteins KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20100447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Effect+of+Sexually+Transmitted+Disease+%28STD%29+Coinfections+on+Performance+of+Three+Commercially+Available+Immunosorbent+Assays+Used+for+Detection+of+Herpes+Simplex+Virus+Type+2-Specific+Antibody+in+Men+Attending+Baltimore%2C+Maryland%2C+STD+Clinics&rft.au=Summerton%2C+Jean%3BRiedesel%2C+Melissa%3BLaeyendecker%2C+Oliver%3BGaydos%2C+Charlotte%3BMaldeis%2C+Nancy+E%3BHardick%2C+Andrew%3BMorrow%2C+Rhoda+Ashley%3BQuinn%2C+Thomas+C&rft.aulast=Summerton&rft.aufirst=Jean&rft.date=2007-12-01&rft.volume=14&rft.issue=12&rft.spage=1545&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Western blotting; Antibodies; Sexually-transmitted diseases; Regression analysis; Glycoproteins; Infection; Immunosorbents; Models; Trichomonas vaginalis; Hepatitis C virus; Mycoplasma genitalium; Human immunodeficiency virus 1; Herpes simplex virus 1; Chlamydia trachomatis; Herpes simplex virus 2; Neisseria gonorrhoeae ER - TY - JOUR T1 - Stem cells: Current challenges and future promise AN - 20005183; 7760795 AB - Stem cells have two remarkable properties. They can either renew themselves or they can differentiate into one or more adult cell types. Stem cells derived from a human embryo appear to have an unlimited capacity to self-renew in cell culture, and they are also able to differentiate into hundreds of adult cell types. Human embryonic stem cell lines offer a platform technology that has the potential to elucidate the molecular mechanisms that determine adult cell fate, generate cellular models for discovery of new drugs, and create populations of differentiated cells for novel transplantation therapies. The National Institutes of Health (NIH) has identified some of the rate-limiting steps toward realizing this potential, and has forged funding initiatives to accelerate research progress. Given the remarkable potential, NIH support for research using stem cells is an important priority for the foreseeable future. JF - Developmental Dynamics AU - Battey, James F AD - National Institutes of Health, Bethesda, Maryland, batteyj@nidcd.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3193 EP - 3198 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 236 IS - 12 SN - 1058-8388, 1058-8388 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Drug discovery KW - Stem cells KW - Embryo cells KW - Cell culture KW - Cell fate KW - Immunosuppressive agents KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20005183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Developmental+Dynamics&rft.atitle=Stem+cells%3A+Current+challenges+and+future+promise&rft.au=Battey%2C+James+F&rft.aulast=Battey&rft.aufirst=James&rft.date=2007-12-01&rft.volume=236&rft.issue=12&rft.spage=3193&rft.isbn=&rft.btitle=&rft.title=Developmental+Dynamics&rft.issn=10588388&rft_id=info:doi/10.1002%2Fdvdy.21203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Drug discovery; Molecular modelling; Stem cells; Embryo cells; Cell culture; Cell fate; Immunosuppressive agents DO - http://dx.doi.org/10.1002/dvdy.21203 ER - TY - JOUR T1 - The Human Insulin Gene Displays Transcriptionally Active Epigenetic Marks in Islet-Derived Mesenchymal Precursor Cells in the Absence of Insulin Expression AN - 19993678; 7938056 AB - Human islet-derived precursor cells (hIPCs), mesenchymal cells derived in vitro from adult pancreas, proliferate freely and do not express insulin but can be differentiated to epithelial cells that express insulin. hIPCs have been studied with the goal of obtaining large quantities of insulin-producing cells suitable for transplantation into patients suffering from type 1 diabetes. It appeared that undifferentiated hIPCs are "committed" to a pancreatic endocrine phenotype through multiple cell divisions, suggesting that epigenetic modifications at the insulin locus could be responsible. We determined patterns of histone modifications over the insulin gene in human islets and hIPCs and compared them with HeLa and human bone marrow-derived mesenchymal stem cells (hBM-MSCs), neither of which expresses insulin. The insulin gene in islets displays high levels of histone modifications (H4 hyperacetylation and dimethylation of H3 lysine 4) typical of active genes. These are not present in HeLa and hBM-MSCs, which instead have elevated levels of H3 lysine 9 dimethylation, a mark of inactive genes. hIPCs, in contrast, show significant levels of active chromatin modifications, as much as half those seen in islets, and show no measurable H3 K9 methylation. Cells expanded from a minor population of mesenchymal stromal cells found in islets exhibit the same histone modifications as established hIPCs. We conclude that hIPCs, which do not express the insulin gene, nonetheless uniquely exhibit epigenetic marks that could poise them for activation of insulin expression. This epigenetic signature may be a general mechanism whereby tissue-derived precursor cells are committed to a distinct specification. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Mutskov, Vesco AU - Raaka, Bruce M AU - Felsenfeld, Gary AU - Gershengorn, Marvin C AD - Laboratory of Molecular Biology and Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3223 EP - 3233 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Epithelial cells KW - Histones KW - Chromatin KW - stromal cells KW - Pancreas KW - Bone marrow KW - Lysine KW - Transcription KW - Islets of Langerhans KW - Insulin KW - Pancreas transplantation KW - Diabetes mellitus KW - Cell division KW - Stem cells KW - epigenetics KW - DNA methylation KW - Mesenchyme KW - Methylation KW - W 30920:Tissue Engineering KW - G 07730:Development & Cell Cycle KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Human+Insulin+Gene+Displays+Transcriptionally+Active+Epigenetic+Marks+in+Islet-Derived+Mesenchymal+Precursor+Cells+in+the+Absence+of+Insulin+Expression&rft.au=Mutskov%2C+Vesco%3BRaaka%2C+Bruce+M%3BFelsenfeld%2C+Gary%3BGershengorn%2C+Marvin+C&rft.aulast=Mutskov&rft.aufirst=Vesco&rft.date=2007-12-01&rft.volume=25&rft.issue=12&rft.spage=3223&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Histones; stromal cells; Chromatin; Pancreas; Bone marrow; Transcription; Lysine; Islets of Langerhans; Insulin; Pancreas transplantation; Diabetes mellitus; Stem cells; Cell division; epigenetics; DNA methylation; Mesenchyme; Methylation ER - TY - JOUR T1 - Genome Sequence Analysis of the Emerging Human Pathogenic Acetic Acid Bacterium Granulibacter bethesdensis AN - 19900078; 7741959 AB - Chronic granulomatous disease (CGD) is an inherited immune deficiency characterized by increased susceptibility to infection with Staphylococcus, certain gram-negative bacteria, and fungi. Granulibacter bethesdensis, a newly described genus and species within the family Acetobacteraceae, was recently isolated from four CGD patients residing in geographically distinct locales who presented with fever and lymphadenitis. We sequenced the genome of the reference strain of Granulibacter bethesdensis, which was isolated from lymph nodes of the original patient. The genome contains 2,708,355 base pairs in a single circular chromosome, in which 2,437 putative open reading frames (ORFs) were identified, 1,470 of which share sequence similarity with ORFs in the nonpathogenic but related Gluconobacter oxydans genome. Included in the 967 ORFs that are unique to G. bethesdensis are ORFs potentially important for virulence, adherence, DNA uptake, and methanol utilization. GC% values and best BLAST analysis suggested that some of these unique ORFs were recently acquired. Comparison of G. bethesdensis to other known CGD pathogens demonstrated conservation of some putative virulence factors, suggesting possible common mechanisms involved in pathogenesis in CGD. Genotyping of the four patient isolates by use of a custom microarray demonstrated genome-wide variations in regions encoding DNA uptake systems and transcriptional regulators and in hypothetical ORFs. G. bethesdensis is a genetically diverse emerging human pathogen that may have recently acquired virulence factors new to this family of organisms. JF - Journal of Bacteriology AU - Greenberg, David E AU - Porcella, Stephen F AU - Zelazny, Adrian M AU - Virtaneva, Kimmo AU - Sturdevant, Dan E AU - Kupko, John JIII AU - Barbian, Kent D AU - Babar, Amenah AU - Dorward, David W AU - Holland, Steven M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland 20892. Research Technologies Section, Genomics Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840. Research Technologies Section, Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Hamilton, Montana 59840 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 8727 EP - 8736 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - virulence factors KW - Genotyping KW - Nucleotide sequence KW - Fungi KW - Staphylococcus KW - Methanol KW - Transcription KW - Gluconobacter oxydans KW - Pathogens KW - DNA microarrays KW - Acetic acid KW - Lymph nodes KW - Fever KW - Guanylate cyclase KW - Lymphadenitis KW - Gram-negative bacteria KW - Chronic infection KW - DNA KW - Conservation KW - Chronic granulomatous disease KW - Open reading frames KW - J 02400:Human Diseases KW - N 14810:Methods KW - G 07770:Bacteria KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19900078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Genome+Sequence+Analysis+of+the+Emerging+Human+Pathogenic+Acetic+Acid+Bacterium+Granulibacter+bethesdensis&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BZelazny%2C+Adrian+M%3BVirtaneva%2C+Kimmo%3BSturdevant%2C+Dan+E%3BKupko%2C+John+JIII%3BBarbian%2C+Kent+D%3BBabar%2C+Amenah%3BDorward%2C+David+W%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2007-12-01&rft.volume=189&rft.issue=23&rft.spage=8727&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; virulence factors; Fungi; Nucleotide sequence; Genotyping; Methanol; Transcription; Pathogens; Acetic acid; DNA microarrays; Lymph nodes; Fever; Guanylate cyclase; Lymphadenitis; Gram-negative bacteria; Chronic infection; DNA; Conservation; Chronic granulomatous disease; Open reading frames; Staphylococcus; Gluconobacter oxydans ER - TY - JOUR T1 - Transgenic Expression of Bcl-x sub(L) or Bcl-2 by Murine B Cells Enhances the In Vivo Antipolysaccharide, but Not Antiprotein, Response to Intact Streptococcus pneumoniae AN - 19894073; 7743252 AB - IgG antipolysaccharide (PS) and antiprotein responses to Streptococcus pneumoniae (Pn) are both CD4 super(+) T cell dependent. However, the primary IgG anti-PS response terminates more quickly, uses a shorter period of T cell help, fails to generate memory, and is more dependent on membrane Ig (mIg) signaling. We thus determined whether this limited anti-PS response to Pn reflected a greater propensity of PS-specific B cells to undergo apoptosis. We used mice that constitutively expressed the antiapoptotic protein Bcl-x sub(L) or Bcl-2 as a B cell-specific transgene. Both transgenic (Tg) mice exhibited increased absolute numbers of splenic B-1 and peritoneal B-1b and B-2 cells, subsets implicated in anti-PS responses, but not in marginal zone B (MZB) cells. Both Tg mouse strains elicited, in an apparently Fas-independent manner, a more prolonged and higher peak primary IgM and IgG anti-PS, but not antiprotein, response to Pn, but without PS-specific memory. A similar effect was not observed using purified PS or pneumococcal conjugate vaccine. In vitro, both splenic MZB and follicular Tg B cells synthesized DNA at markedly higher levels than their wild-type counterparts, following mIg cross-linking. This was associated with increased clonal expansion and decreased apoptosis. Using Lsc super(-/-) mice, the Pn-induced IgG response specific for the capsular PS was found to be almost entirely dependent on MZB cells. Collectively, these data suggest that apoptosis may limit mIg-dependent clonal expansion of PS-specific B cells during a primary immune response to an intact bacterium, as well as decrease the pool of PS-responding B cell subsets. JF - Journal of Immunology AU - Chattopadhyay, Gouri AU - Khan, Abdul Q AU - Sen, Goutam AU - Colino, Jesus AU - duBois, Wendy AU - Rubtsov, Anatoly AU - Torres, Raul M AU - Potter, Michael AU - Snapper, Clifford M AD - Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814. Center for Vaccine Development, University of Maryland, Baltimore, MD 21201. Laboratory of Genetics, National Cancer Institute, Bethesda, MD 20892. University of Colorado Health Sciences Center, Denver, CO 80207. Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80207 Y1 - 2007/12/01/ PY - 2007 DA - 2007 Dec 01 SP - 7523 EP - 7534 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 11 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Apoptosis KW - Data processing KW - Lymphocytes B KW - Peritoneum KW - Memory cells KW - Spleen KW - Transgenic mice KW - Bcl-x protein KW - Streptococcus pneumoniae KW - CD4 antigen KW - Lymphocytes T KW - Immunoglobulin G KW - DNA KW - Vaccines KW - Bcl-2 protein KW - Immunoglobulin M KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19894073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Transgenic+Expression+of+Bcl-x+sub%28L%29+or+Bcl-2+by+Murine+B+Cells+Enhances+the+In+Vivo+Antipolysaccharide%2C+but+Not+Antiprotein%2C+Response+to+Intact+Streptococcus+pneumoniae&rft.au=Chattopadhyay%2C+Gouri%3BKhan%2C+Abdul+Q%3BSen%2C+Goutam%3BColino%2C+Jesus%3BduBois%2C+Wendy%3BRubtsov%2C+Anatoly%3BTorres%2C+Raul+M%3BPotter%2C+Michael%3BSnapper%2C+Clifford+M&rft.aulast=Chattopadhyay&rft.aufirst=Gouri&rft.date=2007-12-01&rft.volume=179&rft.issue=11&rft.spage=7523&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; Lymphocytes B; Peritoneum; Memory cells; Spleen; Transgenic mice; Bcl-x protein; CD4 antigen; DNA; Immunoglobulin G; Lymphocytes T; Bcl-2 protein; Vaccines; Immunoglobulin M; Signal transduction; Streptococcus pneumoniae ER - TY - JOUR T1 - The High-Precision Solution Structure of Yersinia Modulating Protein YmoA Provides Insight into Interaction with H-NS AN - 19891502; 8019312 AB - The high-resolution solution structure of Yersinia modulating protein YmoA is presented. The protein is all helical with the first three of four helices forming the central core. Structures calculated with only NOE and dihedral restraints exhibit a backbone root-mean-square deviation (rmsd) of 0.77 Aa. Upon refinement against H super(alpha)-C super(alpha), H super(N)-N, and C super(alpha)-C' J-modulated residual dipolar couplings, the backbone rmsd improves to 0.22 Aa. YmoA has a high amino acid sequence identity to and a similar overall fold to Escherichia coli hemolysin expression modulating protein Hha; however, structural differences do occur. YmoA is also found to be structurally similar to the histone-like nucleoid structuring protein H- NS, indicating that YmoA may intercalate into higher-order H-NS suprastructuring by substituting for an H-NS dimer. JF - Biochemistry (Washington) AU - McFeeters, Robert L AU - Altieri, Ama S AU - Cherry, Scott AU - Tropea, Joseph E AU - Waugh, David S AU - Byrd, RAndrew AD - Structural Biophysics Laboratory and Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201 Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 13975 EP - 13982 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 46 IS - 49 SN - 0006-2960, 0006-2960 KW - Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Protein folding KW - Escherichia coli KW - Nucleoids KW - Yersinia KW - Hemolysins KW - Amino acid sequence KW - N 14820:DNA Metabolism & Structure KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19891502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=The+High-Precision+Solution+Structure+of+Yersinia+Modulating+Protein+YmoA+Provides+Insight+into+Interaction+with+H-NS&rft.au=McFeeters%2C+Robert+L%3BAltieri%2C+Ama+S%3BCherry%2C+Scott%3BTropea%2C+Joseph+E%3BWaugh%2C+David+S%3BByrd%2C+RAndrew&rft.aulast=McFeeters&rft.aufirst=Robert&rft.date=2007-12-01&rft.volume=46&rft.issue=49&rft.spage=13975&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi701210jPII%3AS0006-2960%2870%2901210-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Protein folding; Nucleoids; Hemolysins; Amino acid sequence; Escherichia coli; Yersinia DO - http://dx.doi.org/10.1021/bi701210jPII:S0006-2960(70)01210-2 ER - TY - JOUR T1 - Atomic-resolution crystal structure of the antiviral lectin scytovirin AN - 19886321; 7745951 AB - The crystal structures of the natural and recombinant antiviral lectin scytovirin (SVN) were solved by single-wavelength anomalous scattering and refined with data extending to 1.3 Aa and 1.0 Aa resolution, respectively. A molecule of SVN consists of a single chain 95 amino acids long, with an almost perfect sequence repeat that creates two very similar domains (RMS deviation 0.25 Aa for 40 pairs of C alpha atoms). The crystal structure differs significantly from a previously published NMR structure of the same protein, with the RMS deviations calculated separately for the N- and C-terminal domains of 5.3 Aa and 3.7 Aa, respectively, and a very different relationship between the two domains. In addition, the disulfide bonding pattern of the crystal structures differs from that described in the previously published mass spectrometry and NMR studies. JF - Protein Science AU - Moulaei, Tinoush AU - Botos, Istvan AU - Ziolkowska, Natasza E AU - Bokesch, Heidi R AU - Krumpe, Lauren R AU - McKee, Tawnya C AU - O'Keefe, Barry R AU - Dauter, Zbigniew AU - Wlodawer, Alexander AD - Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA. SAIC-Frederick Inc., National Cancer Institute, Frederick, Maryland 21702-1201, USA. Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Argonne National Laboratory, Argonne, Illinois 60439, USA Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 2756 EP - 2760 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 12 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Data processing KW - Crystal structure KW - N.M.R. KW - Lectins KW - Mass spectroscopy KW - Amino acid sequence KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19886321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Atomic-resolution+crystal+structure+of+the+antiviral+lectin+scytovirin&rft.au=Moulaei%2C+Tinoush%3BBotos%2C+Istvan%3BZiolkowska%2C+Natasza+E%3BBokesch%2C+Heidi+R%3BKrumpe%2C+Lauren+R%3BMcKee%2C+Tawnya+C%3BO%27Keefe%2C+Barry+R%3BDauter%2C+Zbigniew%3BWlodawer%2C+Alexander&rft.aulast=Moulaei&rft.aufirst=Tinoush&rft.date=2007-12-01&rft.volume=16&rft.issue=12&rft.spage=2756&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Crystal structure; Lectins; N.M.R.; Mass spectroscopy; Amino acid sequence ER - TY - JOUR T1 - Saccharomyces cerevisiae MutL alpha Is a Mismatch Repair Endonuclease AN - 19790160; 7935124 AB - MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutL alpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X) sub(2)E(X) sub(4)E motif (Kadyrov, F. A., Dzantiev, L., Constantin, N., and Modrich, P. (2006) Cell 126, 297-308). This sequence element is conserved in many MutL homologs, including the PMS1 subunit of Saccharomyces cerevisiae MutL alpha , but is absent in MutL proteins from bacteria like Escherichia coli that rely on d(GATC) methylation for strand directionality. We show that yeast MutL alpha is a strand-directed endonuclease that incises DNA in a reaction that depends on a mismatch, yMutS alpha , yRFC, yPCNA, ATP, and a pre-existing strand break, whereas E. coli MutL is not. Amino acid substitution within the PMS1 DQHA(X) sub(2)E(X) sub(4)E motif abolishes yMutL alpha endonuclease activity in vitro and confers strong genetic instability in vivo, but does not affect yMutL alpha ATPase activity or the ability of the protein to support assembly of the yMutL alpha .yMutS alpha .heteroduplex ternary complex. The loaded form of yPCNA may play an important effector role in directing yMutL alpha incision to the discontinuous strand of a nicked heteroduplex. JF - Journal of Biological Chemistry AU - Kadyrov, Farid A AU - Holmes, Shannon F AU - Arana, Mercedes E AU - Lukianova, Olga A AU - O'Donnell, Mike AU - Kunkel, Thomas A AU - Modrich, Paul AD - Department of Biochemistry and Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina 27710, the Laboratory of Structural Biology and Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, and the Laboratory of DNA Replication and Howard Hughes Medical Institute, Rockefeller University, New York 10021-6399 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37181 EP - 37190 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 51 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - MutL protein KW - mismatch repair KW - Adenosinetriphosphatase KW - Amino acid substitution KW - Escherichia coli KW - DNA KW - Conserved sequence KW - ATP KW - Endonuclease KW - Methylation KW - Saccharomyces cerevisiae KW - J 02410:Animal Diseases KW - K 03330:Biochemistry KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790160?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Saccharomyces+cerevisiae+MutL+alpha+Is+a+Mismatch+Repair+Endonuclease&rft.au=Kadyrov%2C+Farid+A%3BHolmes%2C+Shannon+F%3BArana%2C+Mercedes+E%3BLukianova%2C+Olga+A%3BO%27Donnell%2C+Mike%3BKunkel%2C+Thomas+A%3BModrich%2C+Paul&rft.aulast=Kadyrov&rft.aufirst=Farid&rft.date=2007-12-01&rft.volume=282&rft.issue=51&rft.spage=37181&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - MutL protein; Amino acid substitution; Adenosinetriphosphatase; mismatch repair; DNA; ATP; Conserved sequence; Endonuclease; Methylation; Escherichia coli; Saccharomyces cerevisiae ER - TY - JOUR T1 - MyoD Acetylation Influences Temporal Patterns of Skeletal Muscle Gene Expression AN - 19710399; 7935175 AB - MyoD is sufficient to initiate the skeletal muscle gene expression program. Transcription of certain MyoD target genes occurs in the early phases, whereas that of others is induced only at later stages, although MyoD is present throughout the differentiation process. MyoD acetylation regulates transcriptional competency, yet whether this post-translational modification is equally relevant for activation of all the MyoD targets is unknown. Moreover, the molecular mechanisms through which acetylation ensures that MyoD achieves its optimal activity remain unexplored. To address these two outstanding issues, we have coupled genome-wide expression profiling and chromatin immunoprecipitation in a model system in which MyoD or its nonacetylatable version was inducibly activated in mouse embryonic fibroblasts derived from MyoD super(-/-)/Myf5 super(-/-) mice. Our results reveal that MyoD acetylation influences transcription of selected genes expressed at defined stages of the muscle program by regulating chromatin access of MyoD, histone acetylation, and RNA polymerase II recruitment. JF - Journal of Biological Chemistry AU - Di Padova, Monica AU - Caretti, Giuseppina AU - Zhao, Po AU - Hoffman, Eric P AU - Sartorelli, Vittorio AD - Laboratory of Muscle Stem Cells and Gene Regulation, NIAMS, National Institutes of Health, Bethesda, Maryland 20829 and the Research Center for Genetic Medicine and Children's National Medical Center, Washington, D. C. 20010 Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 37650 EP - 37659 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 52 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Molecular modelling KW - Histones KW - Chromatin KW - Recruitment KW - Immunoprecipitation KW - Transcription KW - MyoD protein KW - Gene expression KW - Acetylation KW - Differentiation KW - DNA-directed RNA polymerase KW - Post-translation KW - Embryo fibroblasts KW - Skeletal muscle KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19710399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=MyoD+Acetylation+Influences+Temporal+Patterns+of+Skeletal+Muscle+Gene+Expression&rft.au=Di+Padova%2C+Monica%3BCaretti%2C+Giuseppina%3BZhao%2C+Po%3BHoffman%2C+Eric+P%3BSartorelli%2C+Vittorio&rft.aulast=Di+Padova&rft.aufirst=Monica&rft.date=2007-12-01&rft.volume=282&rft.issue=52&rft.spage=37650&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Histones; Chromatin; Recruitment; Immunoprecipitation; Transcription; MyoD protein; Gene expression; Differentiation; Acetylation; DNA-directed RNA polymerase; Post-translation; Embryo fibroblasts; Skeletal muscle ER - TY - JOUR T1 - Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters AN - 19705018; 7936724 AB - Camptothecin (CPT) analogues are powerful anticancer agents but are chemically unstable due to their alpha -hydroxylactone six-membered E-ring structure, which is essential for trapping topoisomerase I (Top1)-DNA cleavage complexes. To stabilize the E-ring, CPT keto analogues with a five-membered E-ring lacking the oxygen of the lactone ring (S38809 and S39625) have been synthesized. S39625 has been selected for advanced preclinical development based on its promising activity in tumor models. Here, we show that both keto analogues are active against purified Top1 and selective against Top1 in yeast and human cancer cells. The keto analogues show improved cytotoxicity toward colon, breast, and prostate cancer cells and leukemia cells compared with CPT. The drug-induced Top1-DNA cleavage complexes induced by the keto analogues show remarkable persistence both with purified Top1 and in cells following 1-h drug treatments. Moreover, we find that S39625 is not a substrate for either the ABCB1 (multidrug resistance-1/P-glycoprotein) or ABCG2 (mitoxantrone resistance/breast cancer resistance protein) drug efflux transporters, which sets S39625 apart from the clinically used CPT analogues topotecan or SN-38 (active metabolite of irinotecan). Finally, we show that nanomolar concentrations of S38809 or S39625 induce intense and persistent histone gamma -H2AX. The chemical stability of the keto analogues and the ability of S39625 to produce high levels of persistent Top1-DNA cleavage complex and its potent antiproliferative activity against human cancer cell lines make S39625 a promising new anticancer drug candidate. Histone gamma -H2AX could be used as a biomarker for the upcoming clinical trials of S39625. [Mol Cancer Ther 2007; 6(12):3229-38] JF - Molecular Cancer Therapeutics AU - Takagi, Kazutaka AU - Dexheimer, Thomas S AU - Redon, Christophe AU - Sordet, Olivier AU - Agama, Keli AU - Lavielle, Gilbert AU - Pierre, Alain AU - Bates, Susan E AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland and Institut de Recherches Servier, Croissy sur Seine, France Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 3229 EP - 3238 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 12 SN - 1535-7163, 1535-7163 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Histones KW - Drug resistance KW - Irinotecan KW - Metabolites KW - lactones KW - Clinical trials KW - Leukemia KW - P-Glycoprotein KW - Tumor cell lines KW - Colon KW - Protein transport KW - DNA topoisomerase KW - Drug development KW - Tumors KW - biomarkers KW - Trapping KW - Antitumor agents KW - Camptothecin KW - Oxygen KW - Cytotoxicity KW - Prostate cancer KW - Breast cancer KW - Topotecan KW - mitoxantrone KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19705018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Novel+E-ring+camptothecin+keto+analogues+%28S38809+and+S39625%29+are+stable%2C+potent%2C+and+selective+topoisomerase+I+inhibitors+without+being+substrates+of+drug+efflux+transporters&rft.au=Takagi%2C+Kazutaka%3BDexheimer%2C+Thomas+S%3BRedon%2C+Christophe%3BSordet%2C+Olivier%3BAgama%2C+Keli%3BLavielle%2C+Gilbert%3BPierre%2C+Alain%3BBates%2C+Susan+E%3BPommier%2C+Yves&rft.aulast=Takagi&rft.aufirst=Kazutaka&rft.date=2007-12-01&rft.volume=6&rft.issue=12&rft.spage=3229&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; Histones; Drug resistance; Irinotecan; DNA topoisomerase; Drug development; Metabolites; lactones; Tumors; Antitumor agents; Clinical trials; Trapping; biomarkers; Camptothecin; Leukemia; Oxygen; Cytotoxicity; Tumor cell lines; P-Glycoprotein; Prostate cancer; Colon; Breast cancer; Topotecan; mitoxantrone ER - TY - JOUR T1 - Is Cell Death a Critical End Point for Anticancer Therapies or Is Cytostasis Sufficient? AN - 19683940; 7933822 AB - Since the discovery of conventional chemotherapy and the development of new target-based agents, the importance of cytostasis in anticancer activity has been debated. This review examines the relative importance of both cytostasis and cytotoxicity based on both preclinical data and clinical reports. Several limitations of our basic and clinical methods to evaluate cytostasis and cytotoxicity will be highlighted. Molecular mechanisms of cytostasis will be analyzed, including interference with the cell cycle as well as putative links with necrosis and autophagy. Finally, we will cite evidence that most older and newer compounds are both cytostatic and cytotoxic. The relative role of cytostasis and cytotoxicity on future drug screening and clinical development will be explored. JF - Clinical Cancer Research AU - Rixe, Olivier AU - Fojo, Tito AD - Authors' Affiliations: Medical Oncology Department of the Salpetriere Hospital, Pierre and Marie Curie University, Paris, France and Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 7280 EP - 7287 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 24 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Data processing KW - Chemotherapy KW - Cell cycle KW - Cytostasis KW - Drug screening KW - Cytotoxicity KW - Cell death KW - Necrosis KW - Reviews KW - Phagocytosis KW - Antitumor activity KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19683940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Is+Cell+Death+a+Critical+End+Point+for+Anticancer+Therapies+or+Is+Cytostasis+Sufficient%3F&rft.au=Rixe%2C+Olivier%3BFojo%2C+Tito&rft.aulast=Rixe&rft.aufirst=Olivier&rft.date=2007-12-01&rft.volume=13&rft.issue=24&rft.spage=7280&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Necrosis; Cell death; Cytotoxicity; Data processing; Chemotherapy; Reviews; Cell cycle; Cytostasis; Drug screening; Phagocytosis; Antitumor activity ER - TY - JOUR T1 - Evidence of a conjugal erythromycin resistance element in the Lyme disease spirochete Borrelia burgdorferi AN - 19611389; 8580794 AB - We report the identification of isolates of Borrelia burgdorferi strain B31 that exhibit an unusual macrolide-lincosamide (ML) or macrolide- lincosamide-streptogramin A (MLS sub(A)) antibiotic resistance pattern. Low- passage isolates were resistant to high levels (>100 mu g/mL) of erythromycin, spiramycin and the lincosamides but were sensitive to dalfopristin, an analogue of streptogramin B. Interestingly, the high-passage erythromycin- resistant strain B31 was resistant to quinupristin, an analogue of streptogramin A (25 mu g/mL). Biochemical analysis revealed that resistance was not due to antibiotic inactivation or energy-dependent efflux but was instead due to modification of ribosomes in these isolates. Interestingly, we were able to demonstrate high-frequency transfer of the resistance phenotype via conjugation from B. burgdorferi to Bacillus subtilis (10 super(-2)- 10 super(-4)) or Enterococcus faecalis (10 super(-5)). An intergeneric conjugal system in B. burgdorferi suggests that horizontal gene transfer may play a role in its evolution and is a potential tool for developing new genetic systems to study the pathogenesis of Lyme disease. JF - International Journal of Antimicrobial Agents AU - Jackson, Charlene R AU - Boylan, Julie A AU - Frye, Jonathan G AU - Gherardini, Frank C AD - Antimicrobial Resistance Research Unit, ARS, SAA, USDA, Russell Research Center, Athens, GA 30602, USA, fgherardini@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 496 EP - 504 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 30 IS - 6 SN - 0924-8579, 0924-8579 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Borrelia burgdorferi KW - Erythromycin KW - Antimicrobial resistance KW - Conjugation KW - Dalfopristin KW - Bacillus subtilis KW - Streptogramins KW - Enterococcus faecalis KW - Biochemical analysis KW - Ribosomes KW - Antibiotics KW - Spiramycin KW - quinupristin KW - Spirochetes KW - Gene transfer KW - streptogramin B KW - lincosamides KW - Antibiotic resistance KW - Evolution KW - Lyme disease KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Evidence+of+a+conjugal+erythromycin+resistance+element+in+the+Lyme+disease+spirochete+Borrelia+burgdorferi&rft.au=Jackson%2C+Charlene+R%3BBoylan%2C+Julie+A%3BFrye%2C+Jonathan+G%3BGherardini%2C+Frank+C&rft.aulast=Jackson&rft.aufirst=Charlene&rft.date=2007-12-01&rft.volume=30&rft.issue=6&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2007.07.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Dalfopristin; Streptogramins; Biochemical analysis; Spiramycin; Antibiotics; Ribosomes; quinupristin; Erythromycin; Spirochetes; Gene transfer; streptogramin B; Evolution; Antibiotic resistance; lincosamides; Lyme disease; Bacillus subtilis; Borrelia burgdorferi; Enterococcus faecalis DO - http://dx.doi.org/10.1016/j.ijantimicag.2007.07.013 ER - TY - JOUR T1 - The antimicrobial peptide-sensing system aps of Staphylococcus aureus AN - 19527252; 7998761 AB - Staphylococcus aureus is a leading cause of hospital-associated and, more recently, community-associated infections caused by highly virulent methicillin-resistant strains (CA-MRSA). S. aureus survival in the human host is largely defined by the ability to evade attacks by antimicrobial peptides (AMPs) and other mechanisms of innate host defence. Here we show that AMPs induce resistance mechanisms in CA-MRSA via the aps AMP sensor-regulator system, including (i) the d-alanylation of teichoic acids, (ii) the incorporation of lysyl-phosphatidylglycerol in the bacterial membrane and a concomitant increase in lysine biosynthesis, and (iii) putative AMP transport systems such as the vraFG transporter, for which we demonstrate a function in AMP resistance. In contrast to the aps system of S. epidermidis, induction of the aps response in S. aureus was AMP-selective due to structural differences in the AMP binding loop of the ApsS sensor protein. Finally, using a murine infection model, we demonstrate the importance of the aps regulatory system in S. aureus infection. This study shows that while significant interspecies differences exist in the AMP-aps interaction, the AMP sensor system aps is functional and efficient in promoting resistance to a variety of AMPs in a clinically relevant strain of the important human pathogen S. aureus. JF - Molecular Microbiology AU - Li, Min AU - Cha, David J AU - Lai, Yuping AU - Villaruz, Amer E AU - Sturdevant, Daniel E AU - Otto, Michael AD - Laboratory of Human Bacterial Pathogenesis and, motto@niaid.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 1136 EP - 1147 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 66 IS - 5 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Drug resistance KW - Teichoic acids KW - Animal models KW - Lysine KW - Survival KW - Pathogens KW - Staphylococcus aureus KW - Infection KW - Antimicrobial peptides KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19527252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=The+antimicrobial+peptide-sensing+system+aps+of+Staphylococcus+aureus&rft.au=Li%2C+Min%3BCha%2C+David+J%3BLai%2C+Yuping%3BVillaruz%2C+Amer+E%3BSturdevant%2C+Daniel+E%3BOtto%2C+Michael&rft.aulast=Li&rft.aufirst=Min&rft.date=2007-12-01&rft.volume=66&rft.issue=5&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2007.05986.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Teichoic acids; Drug resistance; Animal models; Survival; Lysine; Pathogens; Infection; Antimicrobial peptides; Staphylococcus aureus DO - http://dx.doi.org/10.1111/j.1365-2958.2007.05986.x ER - TY - JOUR T1 - Transgenic mouse lines expressing Cre recombinase specifically in posterior notochord and notochord AN - 19471296; 8235889 AB - During development, the organizer provides instructive signals to surrounding cells as well as contributing cells to axial structures. To dissect organizer function at different developmental stages, conditional approaches such as the Cre/loxP system for conditional mutagenesis are particularly useful. Here we describe two new Cre transgenic mouse lines, Foxa2 NFP-Cre and Nodal PNC-Cre, with activity in two organizer domains, the posterior notochord (PNC) and notochord. These lines were made using defined regulatory elements from the Foxa2 and Nodal genes that direct Cre expression in overlapping domains of the PNC and notochord. Our detailed analysis of the timing and location of Foxa2 NFP-Cre and Nodal PNC-Cre activity indicates that these lines are appropriate for conditional mutagenesis of genes expressed from early somite stages onward. genesis 45:729-736, 2007. Published 2007 Wiley-Liss, Inc. JF - Genesis AU - Kumar, Amit AU - Yamaguchi, Taihei AU - Sharma, Prashant AU - Kuehn, Michael R AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute, NCI-Frederick, National Institutes of Health, Frederick, Maryland, mkuehn@mail.nih.gov Y1 - 2007/12// PY - 2007 DA - Dec 2007 SP - 729 EP - 736 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 45 IS - 12 SN - 1526-954X, 1526-954X KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Regulatory sequences KW - somites KW - Cre recombinase KW - Notochord KW - Developmental stages KW - Transgenic mice KW - Mutagenesis KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19471296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genesis&rft.atitle=Transgenic+mouse+lines+expressing+Cre+recombinase+specifically+in+posterior+notochord+and+notochord&rft.au=Kumar%2C+Amit%3BYamaguchi%2C+Taihei%3BSharma%2C+Prashant%3BKuehn%2C+Michael+R&rft.aulast=Kumar&rft.aufirst=Amit&rft.date=2007-12-01&rft.volume=45&rft.issue=12&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Genesis&rft.issn=1526954X&rft_id=info:doi/10.1002%2Fdvg.20346 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - somites; Regulatory sequences; Cre recombinase; Developmental stages; Notochord; Transgenic mice; Mutagenesis DO - http://dx.doi.org/10.1002/dvg.20346 ER - TY - JOUR T1 - Some bacteria degrade explosives, others prefer boiling methanol AN - 1753456201; 7981591 JF - Environmental Microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2007/12// PY - 2007 DA - December 2007 SP - 2905 EP - 2910 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 12 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Boiling KW - Methanol KW - Explosives KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1753456201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Some+bacteria+degrade+explosives%2C+others+prefer+boiling+methanol&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2007-12-01&rft.volume=9&rft.issue=12&rft.spage=2905&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2007.01480.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2016-01-01 N1 - Last updated - 2016-02-04 N1 - SubjectsTermNotLitGenreText - Boiling; Methanol; Explosives; Bacteria DO - http://dx.doi.org/10.1111/j.1462-2920.2007.01480.x ER - TY - JOUR T1 - Cellular expression and crystal structure of the murine cytomegalovirus major histocompatibility complex class I-like glycoprotein, m153. AN - 68546656; 17897947 AB - Mouse cytomegalovirus (MCMV), a beta-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted major histocompatibility complex, class I (MHC-I) structure. Functions attributed to some family members include down-regulation of host MHC-I (m152) and NKG2D ligands (m145, m152, and m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical, and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require beta2m or peptide and is expressed at the surface of MCMV-infected cells. Its 2.4-A crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended N terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family. JF - The Journal of biological chemistry AU - Mans, Janet AU - Natarajan, Kannan AU - Balbo, Andrea AU - Schuck, Peter AU - Eikel, Daniel AU - Hess, Sonja AU - Robinson, Howard AU - Simic, Hrvoje AU - Jonjic, Stipan AU - Tiemessen, Caroline T AU - Margulies, David H AD - Molecular Biology Section, Laboratory of Immunology, NIAID, National Institutes of Health, Bethesda, Maryland 20892-1892, USA. Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 SP - 35247 EP - 35258 VL - 282 IS - 48 SN - 0021-9258, 0021-9258 KW - Glycoproteins KW - 0 KW - Histocompatibility Antigens Class I KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Index Medicus KW - Animals KW - Green Fluorescent Proteins -- chemistry KW - Models, Molecular KW - Amino Acid Sequence KW - Mice KW - Fibroblasts -- metabolism KW - NIH 3T3 Cells KW - Molecular Sequence Data KW - Molecular Conformation KW - Sequence Homology, Amino Acid KW - Crystallography, X-Ray -- methods KW - Drosophila KW - Protein Conformation KW - Glycoproteins -- chemistry KW - Gene Expression Regulation KW - Histocompatibility Antigens Class I -- chemistry KW - Muromegalovirus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68546656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Cellular+expression+and+crystal+structure+of+the+murine+cytomegalovirus+major+histocompatibility+complex+class+I-like+glycoprotein%2C+m153.&rft.au=Mans%2C+Janet%3BNatarajan%2C+Kannan%3BBalbo%2C+Andrea%3BSchuck%2C+Peter%3BEikel%2C+Daniel%3BHess%2C+Sonja%3BRobinson%2C+Howard%3BSimic%2C+Hrvoje%3BJonjic%2C+Stipan%3BTiemessen%2C+Caroline+T%3BMargulies%2C+David+H&rft.aulast=Mans&rft.aufirst=Janet&rft.date=2007-11-30&rft.volume=282&rft.issue=48&rft.spage=35247&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-04 N1 - Date created - 2007-11-26 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2O5N; PDB N1 - SuppNotes - Cited By: Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:299-308 [2484163] Mol Cell. 2002 Apr;9(4):789-98 [11983170] Science. 1992 Aug 14;257(5072):919-27 [1323877] J Mol Biol. 1993 Jun 20;231(4):1049-67 [8515464] J Mol Biol. 1993 Dec 20;234(4):946-50 [8263940] Nature. 1994 Nov 24;372(6504):336-43 [7969491] Science. 1996 Aug 2;273(5275):595-603 [8662544] J Virol. 1996 Dec;70(12):8833-49 [8971012] Immunity. 1997 Jan;6(1):57-66 [9052837] Nature. 1997 Apr 3;386(6624):510-4 [9087412] Immunity. 1997 Aug;7(2):273-82 [9285411] J Virol. 1998 Jan;72(1):460-6 [9420246] J Mol Evol. 1998 Apr;46(4):389-400 [9541533] Science. 2002 May 17;296(5571):1323-6 [11950999] Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8826-31 [12060703] Rheumatology (Oxford). 2002 Aug;41(8):857-68 [12154202] Acta Crystallogr D Biol Crystallogr. 2002 Nov;58(Pt 11):1948-54 [12393927] J Infect Dis. 2003 Mar 15;187(6):988-99 [12660946] J Exp Med. 2003 May 19;197(10):1245-53 [12756263] Nucleic Acids Res. 2003 Jul 1;31(13):3497-500 [12824352] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13483-8 [14597723] J Exp Med. 2004 Oct 18;200(8):1075-81 [15477345] Proc Natl Acad Sci U S A. 1986 Oct;83(19):7447-51 [3532114] Nature. 1987 Oct 8-14;329(6139):506-12 [3309677] Nature. 1988 Jan 21;331(6153):269-72 [2827039] J Mol Biol. 2006 Apr 21;358(1):157-71 [16500675] J Biol Chem. 2006 Apr 14;281(15):10439-47 [16455647] Virology. 2006 Sep 1;352(2):450-65 [16781754] Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10128-33 [17537914] Acta Crystallogr D Biol Crystallogr. 1998 Sep 1;54(Pt 5):905-21 [9757107] Bioinformatics. 1999 Apr;15(4):305-8 [10320398] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Exp Med. 2005 Jan 17;201(2):211-20 [15642742] J Virol. 2005 Mar;79(5):2920-30 [15709011] Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):465-71 [15809496] J Immunol. 2005 Dec 1;175(11):7457-65 [16301653] Nucleic Acids Res. 2000 Jan 1;28(1):235-42 [10592235] Biophys J. 2000 Mar;78(3):1606-19 [10692345] Annu Rev Immunol. 2000;18:861-926 [10837078] J Virol. 2000 Aug;74(16):7656-65 [10906222] Trends Microbiol. 2000 Sep;8(9):410-8 [10989308] Rev Immunogenet. 1999;1(1):32-46 [11256571] Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1373-82 [11567148] Immunity. 2002 Jan;16(1):77-86 [11825567] Annu Rev Biochem. 1990;59:253-88 [2115762] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rosiglitazone increases small dense low-density lipoprotein concentration and decreases high-density lipoprotein particle size in HIV-infected patients. AN - 68520100; 18025896 AB - After 12 weeks of rosiglitazone treatment, significant increases in total and small dense low-density lipoprotein, and the total: high-density lipoprotein (HDL)-cholesterol ratio were found. The large HDL concentration and HDL particle size decreased significantly with rosiglitazone compared with placebo. These data indicate the production of a more atherogenic lipid profile with rosiglitazone, a consideration when selecting treatment for the growing population of HIV-infected patients with type 2 diabetes and dyslipidemia. JF - AIDS (London, England) AU - Hadigan, Colleen AU - Mazza, Sasha AU - Crum, Dana AU - Grinspoon, Steven AD - National Institute of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Immunoregulation, Bethesda, Maryland, USA. Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 SP - 2543 EP - 2546 VL - 21 IS - 18 KW - Hypoglycemic Agents KW - 0 KW - Lipoproteins, HDL KW - Lipoproteins, LDL KW - PPAR gamma KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Index Medicus KW - AIDS/HIV KW - Particle Size KW - Humans KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Insulin Resistance KW - Male KW - Female KW - PPAR gamma -- agonists KW - Lipoproteins, LDL -- blood KW - Hypoglycemic Agents -- therapeutic use KW - HIV-Associated Lipodystrophy Syndrome -- drug therapy KW - Lipoproteins, HDL -- blood KW - Thiazolidinediones -- adverse effects KW - Hypoglycemic Agents -- adverse effects KW - HIV-Associated Lipodystrophy Syndrome -- blood KW - Thiazolidinediones -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68520100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Rosiglitazone+increases+small+dense+low-density+lipoprotein+concentration+and+decreases+high-density+lipoprotein+particle+size+in+HIV-infected+patients.&rft.au=Hadigan%2C+Colleen%3BMazza%2C+Sasha%3BCrum%2C+Dana%3BGrinspoon%2C+Steven&rft.aulast=Hadigan&rft.aufirst=Colleen&rft.date=2007-11-30&rft.volume=21&rft.issue=18&rft.spage=2543&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=1473-5571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-16 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Classification Analysis of HIV RNase H Bioassay T2 - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AN - 39658266; 4741168 JF - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AU - Han, Lianyi AU - Wang, Yanli AU - Bryant, Steve Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 KW - Human immunodeficiency virus KW - Bioassays KW - Classification KW - Ribonuclease H KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39658266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.atitle=Classification+Analysis+of+HIV+RNase+H+Bioassay&rft.au=Han%2C+Lianyi%3BWang%2C+Yanli%3BBryant%2C+Steve&rft.aulast=Han&rft.aufirst=Lianyi&rft.date=2007-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/rocky07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Accuracy of Structure-based Sequence Alignment of Automatic Methods T2 - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AN - 39603428; 4741163 JF - 5th Annual Rocky Mountain Bioinformatics Conference (Rocky 07) AU - Lee, Byungkook AU - Kim, Changhoon Y1 - 2007/11/30/ PY - 2007 DA - 2007 Nov 30 KW - Nucleotide sequence KW - Automation KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39603428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.atitle=Accuracy+of+Structure-based+Sequence+Alignment+of+Automatic+Methods&rft.au=Lee%2C+Byungkook%3BKim%2C+Changhoon&rft.aulast=Lee&rft.aufirst=Byungkook&rft.date=2007-11-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Rocky+Mountain+Bioinformatics+Conference+%28Rocky+07%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iscb.org/rocky07 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Palmitoylation of POTE family proteins for plasma membrane targeting. AN - 68364152; 17904529 AB - The POTE gene family is composed of 13 paralogs and likely evolved by duplications and remodeling of the human genome. One common property of POTE proteins is their localization on the inner aspect of the plasma membrane. To determine the structural elements required for membrane localization, we expressed mutants of different POTEs in 293T cells as EGFP fusion proteins. We also tested their palmitoylation by a biotin-switch assay. Our data indicate that the membrane localizations of different POTEs are mediated by similar 3-4 short cysteine rich repeats (CRRs) near the amino-terminuses and that palmitoylation on paired cysteine residues in each CRR motif is responsible for the localization. Multiple palmitoylation in the small CRRs can result in the strong association of whole POTEs with plasma membrane. JF - Biochemical and biophysical research communications AU - Das, Sudipto AU - Ise, Tomoko AU - Nagata, Satoshi AU - Maeda, Hiroshi AU - Bera, Tapan K AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4264, USA. Y1 - 2007/11/23/ PY - 2007 DA - 2007 Nov 23 SP - 751 EP - 756 VL - 363 IS - 3 SN - 0006-291X, 0006-291X KW - Membrane Proteins KW - 0 KW - Palmitates KW - Protein Isoforms KW - Recombinant Fusion Proteins KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - 2-bromopalmitate KW - 18263-25-7 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Microscopy, Confocal KW - Immunoblotting KW - Protein Structure, Secondary KW - Cysteine -- metabolism KW - Lipoylation -- drug effects KW - Protein Transport -- drug effects KW - Protein Isoforms -- metabolism KW - Cysteine -- genetics KW - Humans KW - Amino Acid Sequence KW - Palmitates -- pharmacology KW - Mutagenesis KW - Green Fluorescent Proteins -- genetics KW - Cysteine -- chemistry KW - Protein Transport -- genetics KW - Protein Isoforms -- chemistry KW - Amino Acid Motifs KW - Transfection KW - Protein Isoforms -- genetics KW - Mutation KW - Green Fluorescent Proteins -- metabolism KW - Cell Line KW - Recombinant Fusion Proteins -- metabolism KW - Membrane Proteins -- chemistry KW - Membrane Proteins -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Membrane Proteins -- genetics KW - Cell Membrane -- metabolism KW - Recombinant Fusion Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Palmitoylation+of+POTE+family+proteins+for+plasma+membrane+targeting.&rft.au=Das%2C+Sudipto%3BIse%2C+Tomoko%3BNagata%2C+Satoshi%3BMaeda%2C+Hiroshi%3BBera%2C+Tapan+K%3BPastan%2C+Ira&rft.aulast=Das&rft.aufirst=Sudipto&rft.date=2007-11-23&rft.volume=363&rft.issue=3&rft.spage=751&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FEBS Lett. 2002 Feb 20;513(1):119-23 [11911890] J Biol Chem. 2007 Mar 30;282(13):10047-56 [17272284] Trends Cell Biol. 2003 Jan;13(1):32-42 [12480338] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16975-80 [12475935] Biotechniques. 2004 Feb;36(2):276-85 [14989092] Protein Sci. 2004 Jun;13(6):1435-48 [15152081] Annu Rev Biochem. 2004;73:559-87 [15189153] Gene. 2004 Aug 4;337:45-53 [15276201] Cancer Res. 2004 Oct 15;64(20):7455-63 [15492270] J Cell Biol. 1982 Apr;93(1):97-102 [7068762] Cell. 1985 Sep;42(2):497-505 [2992801] Trends Biochem Sci. 1995 May;20(5):181-7 [7610481] Curr Opin Cell Biol. 1997 Apr;9(2):148-54 [9069258] Biochim Biophys Acta. 1999 Aug 12;1451(1):1-16 [10446384] Science. 2005 Mar 18;307(5716):1746-52 [15705808] J Cell Sci. 2005 Apr 15;118(Pt 8):1687-92 [15811950] Curr Opin Neurobiol. 2005 Oct;15(5):527-35 [16125924] Crit Care Med. 2005 Dec;33(12 Suppl):S407-9 [16340406] Cancer Res. 2006 Jan 1;66(1):52-6 [16397215] Gene. 2006 Feb 1;366(2):238-45 [16364570] Bioinformatics. 2006 Apr 1;22(7):894-6 [16434441] Cell. 2006 Jun 2;125(5):1003-13 [16751107] Methods. 2006 Oct;40(2):191-7 [17012032] BMC Bioinformatics. 2006;7:458 [17044919] Sci STKE. 2006 Oct 31;2006(359):re14 [17077383] Proc Natl Acad Sci U S A. 2006 Nov 21;103(47):17885-90 [17101985] Biol Res. 2002;35(2):139-50 [12415731] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Poxvirus DNA primase. AN - 68551375; 18000036 AB - Poxviruses are large enveloped viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. At least six virus-encoded proteins are required for synthesis and processing of the double-stranded DNA genome of vaccinia virus, the prototype member of the family. One of these proteins, D5, is an NTPase that contains an N-terminal archaeoeukaryotic primase domain and a C-terminal superfamily III helicase domain. Here we report that individual conserved aspartic acid residues in the predicted primase active site were required for in vivo complementation of infectious virus formation as well as genome and plasmid replication. Furthermore, purified recombinant D5 protein synthesized oligoribonucleotides in vitro. Incorporation of label from [alpha-(32)P]CTP or [alpha-(32)P]UTP into a RNase-sensitive and DNase-resistant product was demonstrated by using single-stranded circular bacteriophage DNA templates and depended on ATP or GTP and a divalent cation. Mutagenesis studies showed that the primase and NTPase activities of the recombinant D5 protein could be independently inactivated. Highly conserved orthologs of D5 are present in all poxviruses that have been sequenced, and more diverged orthologs are found in members of all other families of nucleocytoplasmic large DNA viruses. These viral primases may have roles in initiation of DNA replication or lagging-strand synthesis and represent potential therapeutic targets. JF - Proceedings of the National Academy of Sciences of the United States of America AU - De Silva, Frank S AU - Lewis, Whitney AU - Berglund, Peter AU - Koonin, Eugene V AU - Moss, Bernard AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3210, USA. Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 18724 EP - 18729 VL - 104 IS - 47 KW - Amino Acids KW - 0 KW - Oligonucleotides KW - DNA Primase KW - EC 2.7.7.- KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - Index Medicus KW - Genome, Viral -- genetics KW - Plasmids -- genetics KW - HeLa Cells KW - Humans KW - Amino Acids -- genetics KW - Mutation -- genetics KW - Amino Acids -- metabolism KW - Acid Anhydride Hydrolases -- metabolism KW - Genetic Vectors -- genetics KW - Oligonucleotides -- metabolism KW - Catalysis KW - Binding Sites KW - DNA Primase -- genetics KW - Poxviridae -- enzymology KW - Poxviridae -- genetics KW - DNA Primase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68551375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Poxvirus+DNA+primase.&rft.au=De+Silva%2C+Frank+S%3BLewis%2C+Whitney%3BBerglund%2C+Peter%3BKoonin%2C+Eugene+V%3BMoss%2C+Bernard&rft.aulast=De+Silva&rft.aufirst=Frank&rft.date=2007-11-20&rft.volume=104&rft.issue=47&rft.spage=18724&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-11-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11178-92 [15249657] Virology. 2007 Apr 10;360(2):376-87 [17156813] Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4879-84 [10781095] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8926-31 [10890916] Annu Rev Biochem. 2001;70:39-80 [11395402] J Virol. 2003 Jan;77(1):159-66 [12477821] Virology. 2002 Nov 25;303(2):232-9 [12490386] J Struct Biol. 2004 Apr-May;146(1-2):11-31 [15037234] Annu Rev Biochem. 2004;73:589-615 [15189154] J Cell Biol. 1976 Mar;68(3):557-66 [1030704] Virology. 1977 May 1;78(1):57-75 [860412] Virology. 1977 Oct 15;82(2):308-22 [919343] J Biol Chem. 1979 Aug 25;254(16):7812-9 [468791] Virology. 1980 Mar;101(2):520-4 [6244700] Virology. 1981 Jan 15;108(1):241-8 [7269237] Cell. 1981 Dec;27(2 Pt 1):391-401 [6277506] Nucleic Acids Res. 1982 Sep 25;10(18):5673-9 [6292846] Cold Spring Harb Symp Quant Biol. 1983;47 Pt 2:723-9 [6574869] Virology. 1984 Jan 30;132(2):436-44 [6322422] Proc Natl Acad Sci U S A. 1986 Feb;83(3):614-8 [3003742] Virology. 1987 Sep;160(1):110-9 [2820124] J Mol Biol. 1988 Feb 5;199(3):399-413 [3351934] FEBS Lett. 1990 Mar 12;262(1):145-8 [2156730] Virology. 1990 Nov;179(1):267-75 [2219723] Virology. 1991 Feb;180(2):625-32 [1989387] EMBO J. 1991 Dec;10(13):4343-50 [1756739] J Virol. 1992 May;66(5):2934-42 [1560532] J Virol. 1992 Aug;66(8):4710-9 [1629951] J Virol. 1992 Aug;66(8):4884-92 [1321275] EMBO J. 1992 Nov;11(11):4111-8 [1327758] Chromosoma. 1992;102(1 Suppl):S72-82 [1291243] Virology. 1994 Feb;198(2):504-13 [8291232] J Biol Chem. 1994 Dec 9;269(49):31190-7 [7983061] Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):6773-7 [7624318] J Virol. 1995 Sep;69(9):5353-61 [7636979] EMBO J. 1997 Dec 15;16(24):7468-80 [9405375] J Biol Chem. 2004 Dec 10;279(50):52210-7 [15471883] Nucleic Acids Res. 2005;33(12):3875-96 [16027112] J Virol. 2005 Dec;79(24):15084-90 [16306579] Virol J. 2005;2:23 [15784143] J Biol Chem. 2006 Feb 10;281(6):3439-51 [16326701] Virus Res. 2006 Apr;117(1):156-84 [16494962] Mol Biol Cell. 2006 May;17(5):2451-64 [16495336] Bioinformatics. 2006 Dec 1;22(23):2846-50 [17021162] J Virol. 2007 Jan;81(2):844-59 [17093187] J Virol. 2004 Oct;78(19):10238-48 [15367589] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Depression, Inflammation, and Incident Cardiovascular Disease in Women With Suspected Coronary Ischemia AN - 1506196392; 18021871 AB - Depression, Inflammation, and Incident Cardiovascular Disease in Women With Suspected Coronary Ischemia: The National Heart, Lung, and Blood Institute-Sponsored WISE Study Viola Vaccarino, B. Delia Johnson, David S. Sheps, Steven E. Reis, Sheryl F. Kelsey, Vera Bittner, Thomas Rutledge, Leslee J. Shaw, George Sopko, C. Noel Bairey Merz It is unclear whether inflammation is a mechanism linking depression to cardiovascular disease (CVD). We examined whether the level of 2 inflammatory biomarkers, interleukin-6 and C-reactive protein, explained the relationship between depression and CVD in 559 women referred for coronary angiography for suspected coronary ischemia. Women with depression, defined as having both elevated depressive symptoms and a previous diagnosis of depression, showed robust elevations in inflammatory biomarkers at baseline and were also at higher risk of CVD over the follow-up. However, inflammation explained only a small portion of the association between depression and CVD. JF - Journal of the American College of Cardiology AU - Vaccarino, Viola AU - Johnson, B Delia AU - Sheps, David S AU - Reis, Steven E AU - Kelsey, Sheryl F AU - Bittner, Vera AU - Rutledge, Thomas AU - Shaw, Leslee J AU - Sopko, George AU - Bairey Merz, C Noel Y1 - 2007/11/20/ PY - 2007 DA - 2007 Nov 20 SP - 2044 EP - 50 CY - New York PB - Elsevier Limited VL - 50 IS - 21 SN - 07351097 KW - Medical Sciences--Cardiovascular Diseases KW - Biological Markers KW - Interleukin-6 KW - C-Reactive Protein KW - Heart attacks KW - Mental depression KW - Womens health KW - Cardiovascular disease KW - Older people KW - Myocardial Ischemia -- blood KW - Cardiovascular Diseases -- blood KW - Humans KW - Coronary Angiography KW - Inflammation -- blood KW - Aged KW - Myocardial Ischemia -- complications KW - C-Reactive Protein -- analysis KW - Depressive Disorder -- blood KW - Interleukin-6 -- blood KW - Biological Markers -- blood KW - Coronary Artery Disease -- blood KW - Coronary Artery Disease -- radiography KW - Risk Factors KW - Adult KW - Middle Aged KW - Follow-Up Studies KW - Cardiovascular Diseases -- radiography KW - Female KW - Cardiovascular Diseases -- complications KW - Inflammation -- complications KW - Depressive Disorder -- complications KW - Coronary Artery Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1506196392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+College+of+Cardiology&rft.atitle=Depression%2C+Inflammation%2C+and+Incident+Cardiovascular+Disease+in+Women+With+Suspected+Coronary+Ischemia%3A+The+National+Heart%2C+Lung%2C+and+Blood+Institute-Sponsored+WISE+Study&rft.au=Vaccarino%2C+Viola%3BJohnson%2C+B+Delia%3BSheps%2C+David+S%3BReis%2C+Steven+E%3BKelsey%2C+Sheryl+F%3BBittner%2C+Vera%3BRutledge%2C+Thomas%3BShaw%2C+Leslee+J%3BSopko%2C+George%3BBairey+Merz%2C+C+Noel&rft.aulast=Vaccarino&rft.aufirst=Viola&rft.date=2007-11-20&rft.volume=50&rft.issue=21&rft.spage=2044&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+College+of+Cardiology&rft.issn=07351097&rft_id=info:doi/10.1016%2Fj.jacc.2007.07.069 LA - English DB - ProQuest Central N1 - Copyright - Copyright Elsevier Limited Nov 20, 2007 N1 - Last updated - 2014-03-31 DO - http://dx.doi.org/10.1016/j.jacc.2007.07.069 ER - TY - JOUR T1 - Successful treatment of tremor in Wilson's disease by thalamotomy: A case report. AN - 85412732; pmid-17914724 AB - Little information is available on the surgical treatment of movement disorders in Wilson's disease. We report a successful outcome of left-sided stereotactic thalamotomy in a 30-year-old man with Wilson's disease, who had severe postural-kinetic tremor of both hands. The improvement was bilateral. Our case illustrates that stereotactic thalamotomy may be considered as an option in treating severe tremor in selected patients of Wilson's disease and merit further trials.(c) 2007 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pal, Pramod Kumar AU - Sinha, Sanjib AU - Pillai, Shibu AU - Taly, Arun B AU - Abraham, Rojin G AD - Department of Neurology National Institute of Mental Health and Neurosciences, Bangalore, India. palpramod@hotmail.com Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2287 EP - 2290 VL - 22 IS - 15 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Hepatolenticular Degeneration: complications KW - Hepatolenticular Degeneration: pathology KW - Humans KW - Magnetic Resonance Imaging KW - Male KW - *Neurosurgical Procedures KW - *Thalamus: surgery KW - *Tremor: etiology KW - Tremor: pathology KW - *Tremor: surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85412732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Successful+treatment+of+tremor+in+Wilson%27s+disease+by+thalamotomy%3A+A+case+report.&rft.au=Pal%2C+Pramod+Kumar%3BSinha%2C+Sanjib%3BPillai%2C+Shibu%3BTaly%2C+Arun+B%3BAbraham%2C+Rojin+G&rft.aulast=Pal&rft.aufirst=Pramod&rft.date=2007-11-15&rft.volume=22&rft.issue=15&rft.spage=2287&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. AN - 68514356; 17982122 AB - CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. Previously, we showed immune-related adverse events (IRAE) and objective, durable clinical responses in patients with metastatic melanoma treated with CTLA-4 blockade. We have now treated 139 patients in two trials and have sufficient follow-up to examine factors associated with clinical response. A total of 139 patients with metastatic melanoma were treated: 54 patients received ipilimumab in conjunction with peptide vaccinations and 85 patients were treated with intra-patient dose escalation of ipilimumab and randomized to receive peptides in accordance with HLA-A*0201 status. Three patients achieved complete responses (CR; ongoing at 29+, 52+, and 53+ months); an additional 20 patients achieved partial responses (PR) for an overall objective response rate of 17%. The majority of patients (62%, 86 of 139) developed some form of IRAE, which was associated with a greater probability of objective antitumor response (P = 0.0004); all patients with CR had more severe IRAEs. Prior therapy with IFNalpha-2b was a negative prognostic factor, whereas prior high-dose interleukin-2 did not significantly affect the probability of response. There were no significant differences in the rate of clinical response or development of IRAEs between the two trials. The duration of tumor response was not affected by the use of high-dose steroids for abrogation of treatment-related toxicities (P = 0.23). There were no treatment-related deaths. In patients with metastatic melanoma, ipilimumab can induce durable objective clinical responses, which are related to the induction of IRAEs. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Downey, Stephanie G AU - Klapper, Jacob A AU - Smith, Franz O AU - Yang, James C AU - Sherry, Richard M AU - Royal, Richard E AU - Kammula, Udai S AU - Hughes, Marybeth S AU - Allen, Tamika E AU - Levy, Catherine L AU - Yellin, Michael AU - Nichol, Geoffrey AU - White, Donald E AU - Steinberg, Seth M AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 6681 EP - 6688 VL - 13 IS - 22 Pt 1 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - Antigens, CD KW - Antigens, Differentiation KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Humans KW - Treatment Outcome KW - Prognosis KW - Aged KW - Middle Aged KW - Male KW - Female KW - Skin Neoplasms -- drug therapy KW - Skin Neoplasms -- immunology KW - Melanoma -- secondary KW - Melanoma -- drug therapy KW - Skin Neoplasms -- pathology KW - Antigens, CD -- drug effects KW - Antibodies, Monoclonal -- pharmacology KW - Melanoma -- immunology KW - Antigens, Differentiation -- drug effects KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68514356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Prognostic+factors+related+to+clinical+response+in+patients+with+metastatic+melanoma+treated+by+CTL-associated+antigen-4+blockade.&rft.au=Downey%2C+Stephanie+G%3BKlapper%2C+Jacob+A%3BSmith%2C+Franz+O%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BRoyal%2C+Richard+E%3BKammula%2C+Udai+S%3BHughes%2C+Marybeth+S%3BAllen%2C+Tamika+E%3BLevy%2C+Catherine+L%3BYellin%2C+Michael%3BNichol%2C+Geoffrey%3BWhite%2C+Donald+E%3BSteinberg%2C+Seth+M%3BRosenberg%2C+Steven+A&rft.aulast=Downey&rft.aufirst=Stephanie&rft.date=2007-11-15&rft.volume=13&rft.issue=22+Pt+1&rft.spage=6681&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] J Immunother. 2007 Jan;30(1):130 [17198092] Annu Rev Immunol. 2001;19:565-94 [11244047] J Exp Med. 2001 Jun 4;193(11):1311-8 [11390438] Eur J Immunol. 2002 Feb;32(2):366-73 [11807776] Nat Rev Immunol. 2001 Dec;1(3):220-8 [11905831] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] Nat Rev Immunol. 2002 Jun;2(6):389-400 [12093005] Science. 2003 Feb 14;299(5609):1057-61 [12522256] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Immunol. 2004 Aug 15;173(4):2866-76 [15295006] J Exp Med. 1991 Mar 1;173(3):721-30 [1847722] J Exp Med. 1991 Mar 1;173(3):759-62 [1847724] J Exp Med. 1991 Sep 1;174(3):561-9 [1714933] J Immunol. 1993 Oct 1;151(7):3489-99 [8397258] Immunity. 1994 Aug;1(5):405-13 [7882171] Science. 1995 Nov 10;270(5238):985-8 [7481803] Science. 1996 Mar 22;271(5256):1734-6 [8596936] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] J Exp Med. 1996 Jun 1;183(6):2541-50 [8676075] Immunity. 1997 Dec;7(6):885-95 [9430233] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10067-71 [9707601] Ann Surg. 1998 Sep;228(3):307-19 [9742914] J Immunol. 1999 May 15;162(10):5813-20 [10229815] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] J Immunother. 2004 Nov-Dec;27(6):478-9 [15534492] J Clin Oncol. 2005 Feb 1;23(4):741-50 [15613700] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Immunother. 2005 Nov-Dec;28(6):593-8 [16224277] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] N Engl J Med. 2006 Feb 16;354(7):709-18 [16481638] J Clin Oncol. 2006 May 20;24(15):2283-9 [16710025] J Immunother. 2006 Jul-Aug;29(4):455-63 [16799341] Blood. 2006 Dec 1;108(12):3818-23 [16882704] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. AN - 68506505; 18006828 AB - The heterogeneous nature of hepatocellular carcinoma (HCC) and the lack of appropriate biomarkers have hampered patient prognosis and treatment stratification. Using a gene expression profiling approach, we recently identified a novel prognostic HCC subtype that resembles hepatic progenitor cells with the activation of stem cell markers and Wnt-beta-catenin signaling, based on EpCAM (epithelial cell adhesion molecule, a hepatic stem cell marker) expression. In this study, we investigated whether the activation of the Wnt-beta-catenin pathway regulates EpCAM expression. We found that nuclear accumulation of beta-catenin induced, whereas the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation reduced EpCAM gene expression in cultured normal human hepatocytes and HCC cell lines. We identified two Tcf binding elements in the EpCAM promoter that specifically bound to Tcf-4 in an electrophoretic mobility shift assay. EpCAM promoter luciferase activity was down-regulated by the degradation of beta-catenin or inhibition of Tcf/beta-catenin complex formation. Furthermore, we found that EpCAM-positive HCC is much more sensitive to Tcf/beta-catenin binding inhibitors than EpCAM-negative HCC in vitro. Taken together, our data indicate that EpCAM is a Wnt-beta-catenin signaling target gene and may be used to facilitate HCC prognosis by enabling effective stratification of patients with predicted pharmacologic responses to Wnt-beta-catenin signaling antagonists. JF - Cancer research AU - Yamashita, Taro AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 10831 EP - 10839 VL - 67 IS - 22 KW - Antigens, Neoplasm KW - 0 KW - Cell Adhesion Molecules KW - Epithelial Cell Adhesion Molecule KW - Wnt Proteins KW - beta Catenin KW - Index Medicus KW - Promoter Regions, Genetic KW - Humans KW - Cell Line, Tumor KW - Cell Proliferation KW - Signal Transduction KW - Wnt Proteins -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Gene Expression Profiling KW - Liver Neoplasms -- metabolism KW - Liver -- cytology KW - Carcinoma, Hepatocellular -- metabolism KW - Antigens, Neoplasm -- biosynthesis KW - beta Catenin -- metabolism KW - Stem Cells -- metabolism KW - Cell Adhesion Molecules -- physiology KW - Cell Adhesion Molecules -- biosynthesis KW - Hepatocytes -- metabolism KW - Antigens, Neoplasm -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68506505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Activation+of+hepatic+stem+cell+marker+EpCAM+by+Wnt-beta-catenin+signaling+in+hepatocellular+carcinoma.&rft.au=Yamashita%2C+Taro%3BBudhu%2C+Anuradha%3BForgues%2C+Marshonna%3BWang%2C+Xin+Wei&rft.aulast=Yamashita&rft.aufirst=Taro&rft.date=2007-11-15&rft.volume=67&rft.issue=22&rft.spage=10831&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Optimization of naphthalimide-imidazoacridone with potent antitumor activity leading to clinical candidate (HKH40A, RTA 502). AN - 68487790; 17939651 AB - Unsymmetrical bifunctional antitumor agent WMC79 was further optimized to generate compound 7b that not only inhibited the growth of many tumor cell lines, but caused rapid apoptosis. Unlike the parent compound, 7b is toxic to both p53 positive and negative cancer cells. It has potent in vivo activity against xenografts of human colon and pancreatic tumors in athymic mice. JF - Journal of medicinal chemistry AU - Hariprakasha, Humcha K AU - Kosakowska-Cholody, Teresa AU - Meyer, Colin AU - Cholody, Wieslaw M AU - Stinson, Sherman F AU - Tarasova, Nadya I AU - Michejda, Christopher J AD - Molecular Aspects of Drug Design Section, Structural Biophysics Laboratory, Center for Cancer Research, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 5557 EP - 5560 VL - 50 IS - 23 SN - 0022-2623, 0022-2623 KW - Acridones KW - 0 KW - Antineoplastic Agents KW - Naphthalimides KW - RTA 502 KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Apoptosis KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Tissue Distribution KW - Tumor Suppressor Protein p53 -- metabolism KW - Structure-Activity Relationship KW - Neoplasm Transplantation KW - Rats KW - Transplantation, Heterologous KW - Naphthalimides -- chemistry KW - Antineoplastic Agents -- pharmacokinetics KW - Acridones -- chemical synthesis KW - Acridones -- chemistry KW - Antineoplastic Agents -- chemical synthesis KW - Acridones -- pharmacology KW - Acridones -- pharmacokinetics KW - Naphthalimides -- pharmacokinetics KW - Naphthalimides -- chemical synthesis KW - Antineoplastic Agents -- pharmacology KW - Naphthalimides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68487790?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Optimization+of+naphthalimide-imidazoacridone+with+potent+antitumor+activity+leading+to+clinical+candidate+%28HKH40A%2C+RTA+502%29.&rft.au=Hariprakasha%2C+Humcha+K%3BKosakowska-Cholody%2C+Teresa%3BMeyer%2C+Colin%3BCholody%2C+Wieslaw+M%3BStinson%2C+Sherman+F%3BTarasova%2C+Nadya+I%3BMichejda%2C+Christopher+J&rft.aulast=Hariprakasha&rft.aufirst=Humcha&rft.date=2007-11-15&rft.volume=50&rft.issue=23&rft.spage=5557&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fear-potentiated startle to threat, and prepulse inhibition among young adult nonsmokers, abstinent smokers, and nonabstinent smokers. AN - 68478551; 17543892 AB - Evidence suggests that the transition from experimental to regular smoking is facilitated by the influence of tobacco on affective and attentional mechanisms. The objective of this study was to examine affective and attentional responses in young adult smokers using fear-potentiated startle and prepulse inhibition. Participants were 56 college nonsmokers, nonabstinent smokers, and overnight-abstinent smokers. The fear-potentiated startle test examined phasic responses to imminent threat cues and more sustained responses to unpredictable aversive events. Prepulse inhibition investigated responses to attended and ignored prepulse stimuli. Abstinent and nonabstinent smokers showed increased sustained potentiation of startle to contextual cues, compared to controls. Abstinent smokers showed increased fear-potentiated startle to threat cues, compared to nonsmokers. PPI did not discriminate between abstinent or nonabstinent smokers and controls. These findings suggest that negative affectivity or anxiety is associated with smoking, particularly during short withdrawal. Potentiated startle may provide a valuable tool in understanding the biologic mechanisms underlying nicotine withdrawal and inform cessation and prevention efforts. JF - Biological psychiatry AU - Grillon, Christian AU - Avenevoli, Shelli AU - Daurignac, Elsa AU - Merikangas, Kathleen R AD - Unit of Affective Psychophysiology, Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland 20892-2670, USA. christian.grillon@nih.gov Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 1155 EP - 1161 VL - 62 IS - 10 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Emotions -- physiology KW - Humans KW - Smoking Cessation KW - Adult KW - Electromyography KW - Habituation, Psychophysiologic KW - Adolescent KW - Acoustic Stimulation -- methods KW - Time Factors KW - Male KW - Female KW - Anxiety -- etiology KW - Smoking -- physiopathology KW - Tobacco Use Disorder -- physiopathology KW - Fear KW - Reflex, Startle -- physiology KW - Inhibition (Psychology) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68478551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Fear-potentiated+startle+to+threat%2C+and+prepulse+inhibition+among+young+adult+nonsmokers%2C+abstinent+smokers%2C+and+nonabstinent+smokers.&rft.au=Grillon%2C+Christian%3BAvenevoli%2C+Shelli%3BDaurignac%2C+Elsa%3BMerikangas%2C+Kathleen+R&rft.aulast=Grillon&rft.aufirst=Christian&rft.date=2007-11-15&rft.volume=62&rft.issue=10&rft.spage=1155&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-01 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Psychiatry. 1997 Nov;154(11):1589-92 [9356569] J Am Acad Child Adolesc Psychiatry. 1997 Jul;36(7):925-32 [9204670] Biol Psychiatry. 1998 Nov 15;44(10):990-7 [9821563] Biol Psychiatry. 1998 Dec 15;44(12):1239-47 [9861467] Pharmacol Biochem Behav. 1999 Feb;62(2):273-84 [9972694] Biol Psychiatry. 2005 Jan 1;57(1):56-66 [15607301] Nicotine Tob Res. 2006 Jun;8(3):379-92 [16801296] Psychophysiology. 2006 Jul;43(4):344-56 [16916430] Am Psychol. 1999 Oct;54(10):817-20 [10540594] Psychopharmacology (Berl). 2000 Jun;150(3):244-52 [10923751] Psychopharmacology (Berl). 2000 Jun;150(3):283-91 [10923756] Arch Gen Psychiatry. 2001 Sep;58(9):810-6 [11545662] Psychopharmacology (Berl). 2001 Jul;156(2-3):117-54 [11549216] Psychopharmacology (Berl). 2001 Jul;156(2-3):194-215 [11549223] Psychopharmacology (Berl). 2001 Jul;156(2-3):266-72 [11549228] Am J Psychiatry. 2002 Jul;159(7):1208-13 [12091201] Psychol Bull. 2003 Mar;129(2):270-304 [12696841] Psychopharmacology (Berl). 2003 May;167(3):235-41 [12677352] Clin Neurophysiol. 2003 Sep;114(9):1557-79 [12948786] Addict Behav. 2004 Jul;29(5):911-9 [15219335] Int J Methods Psychiatr Res. 2004;13(2):93-121 [15297906] Behav Neurosci. 2004 Oct;118(5):916-24 [15506874] J Consult Clin Psychol. 1982 Feb;50(1):71-86 [7056922] Behav Neurosci. 1986 Dec;100(6):814-24 [3545257] Psychophysiology. 1987 May;24(3):278-85 [3602283] Addict Behav. 1987;12(2):195-8 [3630806] J Abnorm Psychol. 1988 Aug;97(3):346-53 [3192830] Psychophysiology. 1989 May;26(3):311-20 [2756080] J Behav Med. 1989 Apr;12(2):159-82 [2668531] Psychopharmacology (Berl). 1992;108(4):485-94 [1410164] Biol Psychiatry. 1993 Aug 15;34(4):253-60 [8399822] Biol Psychol. 1993 Jul;35(3):185-200 [8218613] Psychopharmacology (Berl). 1994 Mar;114(2):369-74 [7838931] Addiction. 1994 Nov;89(11):1461-70 [7841857] Behav Genet. 1995 Mar;25(2):133-47 [7733855] Behav Genet. 1995 Mar;25(2):95-101 [7733862] Psychopharmacology (Berl). 1996 Nov;128(1):54-60 [8944406] Nature. 1998 Jun 4;393(6684):467-70 [9624001] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The DNA polymerase gamma Y955C disease variant associated with PEO and parkinsonism mediates the incorporation and translesion synthesis opposite 7,8-dihydro-8-oxo-2'-deoxyguanosine. AN - 68428336; 17725985 AB - Mitochondrial DNA is replicated and repaired by DNA polymerase gamma (pol gamma), encoded by the POLG gene. The Y955C substitution in POLG leads to autosomal dominant progressive external ophthalmoplegia (PEO) with other severe phenotypes. PEO patients with this mutation can further develop parkinsonism or premature ovarian failure. Mouse and yeast models with this mutation show enhanced amounts of oxidative lesions and increased mtDNA damage. In DNA pol gamma, Tyr955 plays a critical role in catalysis and high fidelity DNA synthesis. 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxo-dG) is one of the most common oxidative lesions in DNA and can promote transversion mutations. Mitochondria are thought to be a major source of endogenous reactive oxygen species that can react with dG to form 8-oxo-dG as one of the more common products. DNA polymerases can mitigate mutagenesis by 8-oxo-dG through allosteric interactions from amino acid side chains, which limit the anti-conformation of the 8-oxo-dG template base during translesion DNA synthesis. Here, we show that the Y955C pol gamma displays relaxed discrimination when either incorporating 8-oxo-dGTP or translesion synthesis opposite 8-oxo-dG. Molecular modeling and biochemical analysis suggest that this residue, Tyr955, in conjunction with Phe961 helps attenuate the anti-conformation in human pol gamma for error free bypass of 8-oxo-dG and substitution to Cys allows the mutagenic syn conformation. Collectively, these results offer a biochemical link between the observed oxidative stress in model systems and parkinsonism in patients, suggesting that patients harboring the Y955C POLG mutation may undergo enhanced oxidative stress and DNA mutagenesis. JF - Human molecular genetics AU - Graziewicz, Maria A AU - Bienstock, Rachelle J AU - Copeland, William C AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2729 EP - 2739 VL - 16 IS - 22 SN - 0964-6906, 0964-6906 KW - 8-oxo-7-hydrodeoxyguanosine KW - 88847-89-6 KW - DNA KW - 9007-49-2 KW - DNA polymerase gamma KW - EC 2.7.7.- KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Models, Molecular KW - Humans KW - Oxidative Stress KW - Deoxyguanosine -- metabolism KW - DNA Replication -- genetics KW - DNA -- genetics KW - Ophthalmoplegia, Chronic Progressive External -- genetics KW - Ophthalmoplegia, Chronic Progressive External -- enzymology KW - DNA -- chemistry KW - Deoxyguanosine -- genetics KW - Parkinsonian Disorders -- enzymology KW - Mutation KW - Parkinsonian Disorders -- genetics KW - DNA-Directed DNA Polymerase -- genetics KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68428336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+molecular+genetics&rft.atitle=The+DNA+polymerase+gamma+Y955C+disease+variant+associated+with+PEO+and+parkinsonism+mediates+the+incorporation+and+translesion+synthesis+opposite+7%2C8-dihydro-8-oxo-2%27-deoxyguanosine.&rft.au=Graziewicz%2C+Maria+A%3BBienstock%2C+Rachelle+J%3BCopeland%2C+William+C&rft.aulast=Graziewicz&rft.aufirst=Maria&rft.date=2007-11-15&rft.volume=16&rft.issue=22&rft.spage=2729&rft.isbn=&rft.btitle=&rft.title=Human+molecular+genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 1999 May;154(5):1423-9 [10329595] Mutat Res. 1999 Jul 30;434(3):137-48 [10486588] Arch Neurol. 2004 Nov;61(11):1777-9 [15534189] Neurobiol Dis. 2005 Feb;18(1):19-31 [15649693] Nat Genet. 2006 May;38(5):515-7 [16604074] Mutat Res. 2006 Jul 25;599(1-2):11-20 [16490220] Hum Mol Genet. 2006 Oct 1;15(19):2846-55 [16940310] Hum Mol Genet. 2006 Oct 15;15 Spec No 2:R244-52 [16987890] Hum Reprod. 2006 Oct;21(10):2467-73 [16595552] Protein Sci. 2006 Nov;15(11):2507-24 [17075131] Neurology. 2006 Nov 14;67(9):1698-700 [16943369] J Biol Chem. 2006 Nov 24;281(47):36241-8 [17005553] Mitochondrion. 2007 Feb-Apr;7(1-2):58-62 [17300997] Lab Invest. 2007 Apr;87(4):326-35 [17310215] J Neurosci Res. 2007 Apr;85(5):919-34 [17279544] Biophys J. 2007 May 1;92(9):3063-70 [17293403] Brain. 2006 Jul;129(Pt 7):1637-9 [16803839] Ann Neurol. 1999 Dec;46(6):920-4 [10589547] J Biol Chem. 1999 Dec 31;274(53):38197-203 [10608893] J Mol Biol. 2000 Sep 8;302(1):205-17 [10964570] Free Radic Biol Med. 2000 Aug;29(3-4):357-67 [11035265] J Biol Chem. 2001 Jun 29;276(26):23616-23 [11319228] Nat Genet. 2001 Jul;28(3):211-2 [11431686] Mol Cell Biol. 2005 Jun;25(12):5196-204 [15923634] Gene. 2005 Jul 18;354:125-31 [15913923] Structure. 2005 Nov;13(11):1653-9 [16271888] Hum Mol Genet. 2006 Jan 15;15(2):363-74 [16368709] J Mol Biol. 2003 May 23;329(1):45-57 [12742017] J Biol Chem. 2003 Sep 5;278(36):33701-7 [12819227] Nucleic Acids Res. 2004;32(1):397-405 [14729924] Nucleic Acids Res. 2004;32(10):3053-64 [15181170] Annu Rev Biochem. 2004;73:293-320 [15189144] Nat Struct Mol Biol. 2004 Aug;11(8):770-6 [15258572] EMBO J. 2004 Sep 1;23(17):3452-61 [15297882] Lancet. 2004 Sep 4-10;364(9437):875-82 [15351195] Nature. 2004 Sep 9;431(7005):217-21 [15322558] J Neurochem. 1986 May;46(5):1501-7 [3485701] J Biol Chem. 1987 Oct 25;262(30):14689-96 [3667598] J Biol Chem. 1990 Nov 25;265(33):20302-7 [1700787] Nature. 1991 Jan 31;349(6308):431-4 [1992344] Nature. 1992 Mar 5;356(6364):83-5 [1538787] J Mol Biol. 1993 Sep 5;233(1):123-38 [8377180] Neurology. 1993 Nov;43(11):2170-2 [8232923] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] Biochemistry. 1994 Apr 19;33(15):4695-701 [8161527] J Biol Chem. 1995 Apr 21;270(16):9202-6 [7721837] Chem Rev. 2006 Feb;106(2):383-405 [16464011] Cell Death Differ. 2006 Apr;13(4):551-63 [16273081] Biol Chem. 2006 Apr;387(4):373-9 [16606334] Ann Neurol. 2006 May;59(5):859-62 [16634032] Nat Genet. 2006 May;38(5):518-20 [16604072] Cancer Res. 2001 Jul 15;61(14):5378-81 [11454679] J Biol Chem. 2001 Oct 19;276(42):38555-62 [11504725] J Biol Chem. 2001 Nov 2;276(44):40847-57 [11526116] Free Radic Biol Med. 2002 May 1;32(9):804-12 [11978482] J Biol Chem. 2002 May 3;277(18):15225-8 [11897778] Mol Cell Biol. 2002 Jun;22(12):4086-93 [12024022] Ann Neurol. 2002 Aug;52(2):211-9 [12210792] Arch Neurol. 2002 Oct;59(10):1541-50 [12374491] Structure. 2003 Jan;11(1):121-7 [12517346] J Biol Chem. 1995 Jun 16;270(24):14659-65 [7782328] Nature. 1996 May 23;381(6580):272 [8692262] Biochemistry. 1997 May 27;36(21):6475-87 [9174365] J Neurochem. 1997 Sep;69(3):1196-203 [9282943] Biochemistry. 1998 Mar 10;37(10):3567-74 [9521678] Biochemistry. 1998 Jul 21;37(29):10529-39 [9671525] Bioinformatics. 1998;14(6):523-8 [9694991] Mutat Res. 1999 Mar 8;424(1-2):51-8 [10064849] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The farnesyltransferase inhibitor R115777 (ZARNESTRA) enhances the pro-apoptotic activity of interferon-alpha through the inhibition of multiple survival pathways. AN - 68335499; 17657738 AB - Interferon alpha (IFNalpha) induces an EGF-Ras-->Raf-1-->Erk dependent survival pathway counteracting apoptosis induced by the cytokine. In this paper we have evaluated the effects of the combination between farnesyl-transferase inhibitor (FTI) R115777 and IFNalpha on the growth inhibition and apoptosis of cancer cells. Simultaneous exposure to R115777 and IFNalpha produced synergistic both antiproliferative and proapoptotic effects. In these experimental conditions, IFNalpha and R115777 completely antagonized the increased activity of both Ras and Erk-1/2 induced by IFNalpha and strongly reduced Akt activity. Furthermore, treatment with R115777 in combination with IFNalpha regimen induced tumor growth delay on established KB cell xenografts in nude mice, while the single agents were almost inactive. R115777 was again able to antagonize the Ras-dependent survival pathway induced by IFNalpha also in vivo. Raf-1, one of the downstream targets of Ras, has been reported to activate bcl-2 through displacement and/or phosphorylation of Bad. We have found that IFNalpha induced mitochondrial localization of Raf-1 that was antagonized by R115777. Moreover, IFNalpha increased Raf-1/bcl-2 immuno-conjugate formation and intracellular co-localization and enhanced phosphorylation of Bad at Ser 112 and again R115777 counteracted all these effects. Moreover, the use of plasmids encoding for dominant negative or dominant positive Raf-1 antagonized and potentiated, respectively, the co-immunoprecipitation between Raf-1 and bcl-2. In conclusion, FTI R115777 strongly potentiates the antitumor activity of IFNalpha both in vitro and in vivo through the inhibition of different survival pathways that are dependent from isoprenylation of intracellular proteins such as ras. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Caraglia, Michele AU - Marra, Monica AU - Viscomi, Caterina AU - D'Alessandro, Anna Maria AU - Budillon, Alfredo AU - Meo, Giuseppina AU - Arra, Claudio AU - Barbieri, Antonio AU - Rapp, Ulf R AU - Baldi, Alfonso AU - Tassone, Pierfrancesco AU - Venuta, Salvatore AU - Abbruzzese, Alberto AU - Tagliaferri, Pierosandro AD - Experimental Pharmacology Unit, Experimental Oncology Department, National Cancer Institute Fondazione "G. Pascale", Naples, Italy. Y1 - 2007/11/15/ PY - 2007 DA - 2007 Nov 15 SP - 2317 EP - 2330 VL - 121 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Interferon-alpha KW - Proto-Oncogene Proteins c-bcl-2 KW - Quinolones KW - Phosphoserine KW - 17885-08-4 KW - Farnesyltranstransferase KW - EC 2.5.1.29 KW - Proto-Oncogene Proteins c-raf KW - EC 2.7.11.1 KW - ras Proteins KW - EC 3.6.5.2 KW - tipifarnib KW - MAT637500A KW - Index Medicus KW - Animals KW - Humans KW - Proto-Oncogene Proteins c-raf -- metabolism KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Mice, Inbred BALB C KW - Phosphoserine -- metabolism KW - Neoplasms -- pathology KW - Cell Survival -- drug effects KW - Signal Transduction -- drug effects KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Mitochondria -- drug effects KW - Antineoplastic Agents -- toxicity KW - Xenograft Model Antitumor Assays KW - Mitochondria -- metabolism KW - ras Proteins -- metabolism KW - Antineoplastic Agents -- therapeutic use KW - Immunohistochemistry KW - Female KW - Protein Transport KW - Neoplasms -- metabolism KW - Quinolones -- toxicity KW - Interferon-alpha -- pharmacology KW - Interferon-alpha -- metabolism KW - Quinolones -- therapeutic use KW - Farnesyltranstransferase -- metabolism KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68335499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=The+farnesyltransferase+inhibitor+R115777+%28ZARNESTRA%29+enhances+the+pro-apoptotic+activity+of+interferon-alpha+through+the+inhibition+of+multiple+survival+pathways.&rft.au=Caraglia%2C+Michele%3BMarra%2C+Monica%3BViscomi%2C+Caterina%3BD%27Alessandro%2C+Anna+Maria%3BBudillon%2C+Alfredo%3BMeo%2C+Giuseppina%3BArra%2C+Claudio%3BBarbieri%2C+Antonio%3BRapp%2C+Ulf+R%3BBaldi%2C+Alfonso%3BTassone%2C+Pierfrancesco%3BVenuta%2C+Salvatore%3BAbbruzzese%2C+Alberto%3BTagliaferri%2C+Pierosandro&rft.aulast=Caraglia&rft.aufirst=Michele&rft.date=2007-11-15&rft.volume=121&rft.issue=10&rft.spage=2317&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=1097-0215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Int J Cancer. 2008 Apr 15;122(8):1922 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A meta-analysis of N-acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. AN - 70054262; 18001477 AB - Meta-analyses of N-acetylcysteine (NAC) for preventing contrast-induced nephrotoxicity (CIN) have led to disparate conclusions. Here we examine and attempt to resolve the heterogeneity evident among these trials. Two reviewers independently extracted and graded the data. Limiting studies to randomized, controlled trials with adequate outcome data yielded 22 reports with 2746 patients. Significant heterogeneity was detected among these trials (I2 = 37%; p = 0.04). Meta-regression analysis failed to identify significant sources of heterogeneity. A modified L'Abbé plot that substituted groupwise changes in serum creatinine for nephrotoxicity rates, followed by model-based, unsupervised clustering resolved trials into two distinct, significantly different (p 0.5, for both). Cluster 1 studies (n = 18; 2445 patients) showed no benefit (relative risk (RR) = 0.87; 95% confidence interval (CI) 0.68-1.12, p = 0.28), while cluster 2 studies (n = 4; 301 patients) indicated that NAC was highly beneficial (RR = 0.15; 95% CI 0.07-0.33, p < 0.0001). Benefit in cluster 2 was unexpectedly associated with NAC-induced decreases in creatinine from baseline (p = 0.07). Cluster 2 studies were relatively early, small and of lower quality compared with cluster 1 studies (p = 0.01 for the three factors combined). Dialysis use across all studies (five control, eight treatment; p = 0.42) did not suggest that NAC is beneficial. This meta-analysis does not support the efficacy of NAC to prevent CIN. JF - BMC medicine AU - Gonzales, Denise A AU - Norsworthy, Kelly J AU - Kern, Steven J AU - Banks, Steve AU - Sieving, Pamela C AU - Star, Robert A AU - Natanson, Charles AU - Danner, Robert L AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA. dgonzales@cc.nih.gov Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 32 VL - 5 KW - Contrast Media KW - 0 KW - Creatinine KW - AYI8EX34EU KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Sensitivity and Specificity KW - Regression Analysis KW - Randomized Controlled Trials as Topic KW - Humans KW - Aged KW - Renal Dialysis KW - Models, Biological KW - Creatinine -- metabolism KW - Risk Factors KW - Publication Bias KW - Middle Aged KW - Cluster Analysis KW - Female KW - Male KW - Contrast Media -- adverse effects KW - Kidney Diseases -- prevention & control KW - Acetylcysteine -- pharmacology KW - Kidney Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70054262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+medicine&rft.atitle=A+meta-analysis+of+N-acetylcysteine+in+contrast-induced+nephrotoxicity%3A+unsupervised+clustering+to+resolve+heterogeneity.&rft.au=Gonzales%2C+Denise+A%3BNorsworthy%2C+Kelly+J%3BKern%2C+Steven+J%3BBanks%2C+Steve%3BSieving%2C+Pamela+C%3BStar%2C+Robert+A%3BNatanson%2C+Charles%3BDanner%2C+Robert+L&rft.aulast=Gonzales&rft.aufirst=Denise&rft.date=2007-11-14&rft.volume=5&rft.issue=&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=BMC+medicine&rft.issn=1741-7015&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-03 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nephrol Dial Transplant. 2006 Jul;21(7):1863-9 [16522657] N Engl J Med. 2006 Jun 29;354(26):2773-82 [16807414] Kardiol Pol. 2006 Jun;64(6):559-64; discussion 565-6 [16810570] Radiology. 2006 Aug;240(2):615; author reply 615 [16864687] Int J Cardiol. 2007 Jan 31;115(1):57-62 [16814414] Am Heart J. 2007 Sep;154(3):539-44 [17719303] J Am Soc Nephrol. 2004 Feb;15(2):251-60 [14747371] J Am Soc Nephrol. 2004 Feb;15(2):407-10 [14747387] Eur Heart J. 2004 Feb;25(3):206-11 [14972420] Eur Heart J. 2004 Feb;25(3):212-8 [14972421] J Am Soc Nephrol. 2004 Mar;15(3):761-9 [14978179] Kidney Int. 2004 Apr;65(4):1366-74 [15086476] WMJ. 2004;103(1):38-41 [15101466] Am J Kidney Dis. 2004 May;43(5):801-8 [15112170] JAMA. 2004 May 19;291(19):2328-34 [15150204] Nephrol Dial Transplant. 2004 Jul;19(7):1803-7 [15128882] J Interv Cardiol. 2004 Jun;17(3):159-65 [15209578] Arch Mal Coeur Vaiss. 2003 Dec;96(12):1157-61 [15248440] Kidney Blood Press Res. 2004;27(3):161-6 [15256811] J Am Coll Cardiol. 2004 Aug 18;44(4):762-5 [15312855] Clin Nephrol. 2004 Aug;62(2):77-83 [15356963] Am Heart J. 2006 Jan;151(1):140-5 [16368307] Am Heart J. 2004 Sep;148(3):422-9 [15389228] Am Heart J. 2004 Oct;148(4):690-5 [15459602] J Am Coll Cardiol. 2004 Oct 6;44(7):1393-9 [15464318] AJR Am J Roentgenol. 1981 May;136(5):859-61 [6784516] Ann Intern Med. 1987 Aug;107(2):224-33 [3300460] Lancet. 1991 Apr 13;337(8746):867-72 [1672966] Biometrics. 1994 Dec;50(4):1088-101 [7786990] BMJ. 1995 Sep 16;311(7007):753-4 [7549720] JAMA. 1996 May 15;275(19):1489-94 [8622223] Control Clin Trials. 1996 Feb;17(1):1-12 [8721797] N Engl J Med. 1997 Aug 21;337(8):536-42 [9262498] BMJ. 1997 Sep 13;315(7109):629-34 [9310563] Am J Med. 1997 Nov;103(5):368-75 [9375704] BMJ. 1998 Jan 17;316(7126):221-5 [9468698] Clin Cardiol. 2004 Nov;27(11):607-10 [15562929] BMC Med. 2004 Oct 22;2:38 [15500690] J Vasc Surg. 2004 Dec;40(6):1136-41 [15622367] Am J Med. 2004 Dec 15;117(12):938-47 [15629733] J Invasive Cardiol. 2005 Feb;17(2):80-4 [15687530] Catheter Cardiovasc Interv. 2005 Apr;64(4):471-9 [15789388] J Gen Intern Med. 2005 Feb;20(2):193-200 [15836554] Lancet. 1999 Nov 27;354(9193):1896-900 [10584742] N Engl J Med. 2000 Jul 20;343(3):180-4 [10900277] Stat Med. 2000 Dec 15;19(23):3251-74 [11113958] Am J Cardiol. 2002 Feb 1;89(3):356-8 [11809444] Arch Intern Med. 2002 Feb 11;162(3):329-36 [11822926] Clin Chem. 2002 May;48(5):699-707 [11978596] J Am Coll Cardiol. 2002 Jul 17;40(2):298-303 [12106935] Stat Med. 2002 Jun 15;21(11):1539-58 [12111919] J Am Coll Cardiol. 2002 Oct 16;40(8):1383-8 [12392825] Am J Respir Crit Care Med. 2002 Nov 1;166(9):1197-205 [12403688] Catheter Cardiovasc Interv. 2002 Nov;57(3):279-83 [12410497] Kidney Int. 2002 Dec;62(6):2202-7 [12427146] G Ital Nefrol. 2002 Sep-Oct;19(5):529-33 [12439841] JAMA. 2003 Feb 5;289(5):553-8 [12578487] Catheter Cardiovasc Interv. 2003 Mar;58(3):336-41 [12594698] J Invasive Cardiol. 2003 Jun;15(6):311-4 [12777667] J Am Coll Cardiol. 2003 Jun 18;41(12):2114-8 [12821233] Lancet. 2003 Aug 23;362(9384):598-603 [12944058] BMJ. 2003 Sep 6;327(7414):557-60 [12958120] Metabolism. 2003 Oct;52(10):1258-64 [14564676] Am J Health Syst Pharm. 2003 Nov 1;60(21):2232-5 [14619114] Catheter Cardiovasc Interv. 2003 Dec;60(4):458-61 [14624421] Kidney Int. 2003 Dec;64(6):2182-7 [14633141] Am Heart J. 2003 Dec;146(6):E23 [14661012] Am J Cardiol. 2003 Dec 15;92(12):1454-8 [14675586] Am J Kidney Dis. 2004 Jan;43(1):1-9 [14712421] Acta Cardiol. 2003 Dec;58(6):555-60 [14713182] Heart. 2005 Jun;91(6):774-8 [15894775] JAMA. 2005 Jul 20;294(3):342-50 [16030279] J Cardiovasc Pharmacol. 2005 Oct;46(4):464-7 [16160598] Rev Fac Cien Med Univ Nac Cordoba. 2004;61(2):13-9 [16211988] Heart Lung Circ. 2005 Dec;14(4):245-51 [16360994] Arch Intern Med. 2006 Jan 23;166(2):161-6 [16432083] BMJ. 2006 Jan 28;332(7535):202-9 [16415336] J Lab Clin Med. 2006 Jan;147(1):7-20 [16443000] Cardiovasc Intervent Radiol. 2006 May-Jun;29(3):344-7 [16502177] Am Heart J. 2006 May;151(5):1032.e9-12 [16644332] Int J Cardiol. 2006 May 24;109(3):322-8 [16039733] Ren Fail. 2006;28(3):265-6 [16703801] Radiology. 2006 Jun;239(3):793-804 [16714461] Anesth Analg. 2006 Jun;102(6):1638-45 [16717300] JAMA. 2006 Jun 21;295(23):2765-79 [16788132] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Profound decreases in dopamine release in striatum in detoxified alcoholics: possible orbitofrontal involvement. AN - 68512482; 18003850 AB - The value of rewards (natural rewards and drugs) is associated with dopamine increases in the nucleus accumbens and varies as a function of context. The prefrontal cortex has been implicated in the context dependency of rewards and in the fixated high value that drugs have in addiction, although the mechanisms are not properly understood. Here we test the hypothesis that the prefrontal cortex regulates the value of rewards by modulating dopamine increases in nucleus accumbens and that this regulation is disrupted in addicted subjects. We used positron emission tomography to evaluate the activity of the prefrontal cortex (measuring brain glucose metabolism with [18F]fluorodeoxyglucose) and dopamine increases (measured with [11C]raclopride, a D2/D3 receptor ligand with binding that is sensitive to endogenous dopamine) induced by the stimulant drug methylphenidate in 20 controls and 20 detoxified alcoholics, most of whom smoked. In all subjects, methylphenidate significantly increased dopamine in striatum. In ventral striatum (where the nucleus accumbens is located) and in putamen, dopamine increases were associated with the rewarding effects of methylphenidate (drug liking and high) and were profoundly attenuated in alcoholics (70 and 50% lower than controls, respectively). In controls, but not in alcoholics, metabolism in orbitofrontal cortex (region involved with salience attribution) was negatively associated with methylphenidate-induced dopamine increases in ventral striatum. These results are consistent with the hypothesis that the orbitofrontal cortex modulates the value of rewards by regulating the magnitude of dopamine increases in the ventral striatum and that disruption of this regulation may underlie the decreased sensitivity to rewards in addicted subjects. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Telang, Frank AU - Fowler, Joanna S AU - Logan, Jean AU - Jayne, Millard AU - Ma, Yeming AU - Pradhan, Kith AU - Wong, Christopher AD - National Institute on Drug Abuse, Bethesda, Maryland 20892, USA. nvolkow@nida.nih.gov Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12700 EP - 12706 VL - 27 IS - 46 KW - Central Nervous System Depressants KW - 0 KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - Methylphenidate KW - 207ZZ9QZ49 KW - Ethanol KW - 3K9958V90M KW - Raclopride KW - 430K3SOZ7G KW - Glucose KW - IY9XDZ35W2 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Neural Pathways -- physiopathology KW - Positron-Emission Tomography KW - Alcoholism -- diagnostic imaging KW - Methylphenidate -- pharmacology KW - Neural Pathways -- metabolism KW - Humans KW - Brain Chemistry -- drug effects KW - Glucose -- metabolism KW - Alcoholism -- metabolism KW - Neural Pathways -- drug effects KW - Down-Regulation -- physiology KW - Central Nervous System Depressants -- adverse effects KW - Adult KW - Middle Aged KW - Alcoholism -- physiopathology KW - Down-Regulation -- drug effects KW - Male KW - Brain Chemistry -- physiology KW - Dopamine Uptake Inhibitors -- pharmacology KW - Ethanol -- adverse effects KW - Alcohol-Induced Disorders, Nervous System -- metabolism KW - Corpus Striatum -- physiopathology KW - Reward KW - Prefrontal Cortex -- metabolism KW - Corpus Striatum -- metabolism KW - Prefrontal Cortex -- physiopathology KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Prefrontal Cortex -- drug effects KW - Alcohol-Induced Disorders, Nervous System -- physiopathology KW - Alcohol-Induced Disorders, Nervous System -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68512482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Profound+decreases+in+dopamine+release+in+striatum+in+detoxified+alcoholics%3A+possible+orbitofrontal+involvement.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BTelang%2C+Frank%3BFowler%2C+Joanna+S%3BLogan%2C+Jean%3BJayne%2C+Millard%3BMa%2C+Yeming%3BPradhan%2C+Kith%3BWong%2C+Christopher&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12700&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects of blockade of dopamine D1-family receptors in nucleus accumbens core or shell on reinstatement of heroin seeking induced by contextual and discrete cues. AN - 68509434; 18003845 AB - In humans, exposure to environmental contexts previously associated with heroin intake can provoke drug relapse, but the neuronal mechanisms mediating this relapse are unknown. Using a drug relapse model, we found previously that reexposing rats to heroin-associated contexts, after extinction of drug-reinforced responding in different contexts, reinstates heroin seeking. This effect is attenuated by inhibition of glutamate transmission in the ventral tegmental area and medial accumbens shell, components of the mesolimbic dopamine system. Here, we explored the role of dopamine of the accumbens in context-induced reinstatement by using the D1-family receptor antagonist SCH 23390 [R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride]. Rats were trained to self-administer heroin for 12 d; drug infusions were paired with a discrete tone-light cue. Subsequently, the heroin-reinforced lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. When tested in the original drug self-administration context, systemic and medial or lateral accumbens shell SCH 23390 injections attenuated context-induced reinstatement of heroin seeking, whereas accumbens core SCH 23390 injections were ineffective. In contrast, core but not lateral or medial shell SCH 23390 injections attenuated discrete-cue-induced reinstatement in a nondrug context after extinction of lever presses without this cue. Results indicate that activation of medial and lateral accumbens shell D1-family dopamine receptors mediate context-induced reinstatement of heroin seeking and provide the first demonstration for a role of lateral shell dopamine in conditioned drug effects. Results also demonstrate novel dissociable roles of accumbens core and shell in context- versus discrete-cue-induced reinstatement of heroin seeking. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Bossert, Jennifer M AU - Poles, Gabriela C AU - Wihbey, Kristina A AU - Koya, Eisuke AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health/Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 SP - 12655 EP - 12663 VL - 27 IS - 46 KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine D1 KW - Index Medicus KW - Animals KW - Benzazepines -- pharmacology KW - Rats, Long-Evans KW - Disease Models, Animal KW - Extinction, Psychological -- physiology KW - Conditioning (Psychology) -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Conditioning (Psychology) -- physiology KW - Cues KW - Behavior, Animal -- physiology KW - Benzazepines -- therapeutic use KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Male KW - Reward KW - Heroin Dependence -- metabolism KW - Dopamine Antagonists -- therapeutic use KW - Nucleus Accumbens -- drug effects KW - Receptors, Dopamine D1 -- antagonists & inhibitors KW - Heroin Dependence -- physiopathology KW - Dopamine Antagonists -- pharmacology KW - Heroin Dependence -- prevention & control KW - Nucleus Accumbens -- metabolism KW - Behavior, Addictive -- physiopathology KW - Nucleus Accumbens -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68509434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Differential+effects+of+blockade+of+dopamine+D1-family+receptors+in+nucleus+accumbens+core+or+shell+on+reinstatement+of+heroin+seeking+induced+by+contextual+and+discrete+cues.&rft.au=Bossert%2C+Jennifer+M%3BPoles%2C+Gabriela+C%3BWihbey%2C+Kristina+A%3BKoya%2C+Eisuke%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2007-11-14&rft.volume=27&rft.issue=46&rft.spage=12655&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Behav Neurosci. 1999 Apr;113(2):324-36 [10357457] Brain Res Rev. 2007 Nov;56(1):27-78 [17574681] Psychopharmacology (Berl). 2004 Nov;176(3-4):459-65 [15138757] J Neurosci. 2004 Nov 24;24(47):10726-30 [15564590] Neuropsychopharmacology. 2005 Feb;30(2):296-309 [15483559] Neuron. 2005 Mar 3;45(5):647-50 [15748840] J Neurosci. 2005 May 18;25(20):5061-5 [15901788] Neuroreport. 2005 Jun 21;16(9):1013-6 [15931079] Nat Neurosci. 2005 Nov;8(11):1481-9 [16251991] Eur J Pharmacol. 2005 Dec 5;526(1-3):36-50 [16289451] Neuropsychopharmacology. 2006 Feb;31(2):363-74 [15957007] Neuroscience. 2006;139(3):877-87 [16516392] Psychopharmacology (Berl). 2006 Aug;187(2):143-53 [16724186] Neuropsychopharmacology. 2006 Oct;31(10):2197-209 [16341024] Psychopharmacology (Berl). 2006 Nov;189(1):1-16 [17019567] Neuroscience. 2006 Nov 17;143(1):25-38 [16949214] Neuropsychopharmacology. 2008 May;33(6):1402-12 [17653111] Neuropsychopharmacology. 2008 May;33(6):1413-25 [17712353] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4321-6 [10760299] Neuroscience. 2000;99(2):267-77 [10938432] Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1976-81 [11172061] Psychopharmacology (Berl). 2001 Jun;156(1):98-107 [11465640] J Neurosci. 2001 Aug 1;21(15):5841-6 [11466456] Neuropsychopharmacology. 2001 Sep;25(3):361-72 [11522464] J Neurosci. 2001 Dec 1;21(23):9471-7 [11717381] Pharmacol Biochem Behav. 2002 Mar;71(3):517-29 [11830186] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Behav Neurosci. 2002 Feb;116(1):169-73 [11895178] Psychopharmacology (Berl). 2002 Apr;160(4):425-33 [11919670] J Neurosci. 2002 May 1;22(9):3312-20 [11978805] Neurosci Biobehav Rev. 2002 May;26(3):321-52 [12034134] Biol Psychiatry. 2002 Nov 15;52(10):976-86 [12437938] Neuropsychopharmacology. 2002 Dec;27(6):1006-15 [12464457] Neuropsychopharmacology. 2003 Feb;28(2):292-9 [12589382] Psychopharmacology (Berl). 2003 Jul;168(1-2):132-8 [12491029] J Neurosci. 2003 Jul 16;23(15):6295-303 [12867514] J Neurosci. 2003 Aug 13;23(19):7239-45 [12917356] J Neurosci. 2003 Oct 15;23(28):9305-11 [14561857] Neurosci Biobehav Rev. 2004 Jan;27(8):765-76 [15019426] Nat Neurosci. 2004 Apr;7(4):389-97 [15034590] Nat Rev Neurosci. 2004 Jun;5(6):483-94 [15152198] Trends Neurosci. 2004 Aug;27(8):468-74 [15271494] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Neuropharmacology. 2004;47 Suppl 1:227-41 [15464140] Arch Gen Psychiatry. 1973 May;28(5):611-6 [4700675] Brain Res. 1975 Mar 28;86(3):399-418 [234776] Pharmacol Rev. 1975 Sep;27(3):325-40 [817305] J Comp Neurol. 1978 Aug 1;180(3):545-80 [659674] Eur J Pharmacol. 1986 Oct 7;129(3):367-70 [3536532] Naunyn Schmiedebergs Arch Pharmacol. 1989 Mar;339(3):252-8 [2725702] J Comp Neurol. 1989 Nov 8;289(2):189-201 [2478598] Br J Pharmacol. 1991 Dec;104(4):1038-44 [1687364] Ann N Y Acad Sci. 1992 Jun 28;654:400-15 [1632593] Neuroscience. 1992 Sep;50(1):149-62 [1383869] Neuroscience. 1992 Oct;50(4):751-67 [1448200] Brain Res. 1995 Sep 18;692(1-2):47-56 [8548319] J Neurosci. 1996 Mar 1;16(5):1957-63 [8774462] Eur J Neurosci. 1997 Dec;9(12):2541-8 [9517459] Neuroscience. 1999 Mar;89(2):473-89 [10077329] Psychopharmacology (Berl). 2007 Apr;191(3):689-703 [17072592] Neuroscience. 2007 May 11;146(2):525-36 [17360123] Ann N Y Acad Sci. 1999 Jun 29;877:140-56 [10415648] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Oxidative Interaction between RNA and Cytochrome C T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40706642; 4755938 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Tanaka, Mikiei AU - Chock, P Boon AU - Stadtman, Earl Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cytochrome c KW - RNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Oxidative+Interaction+between+RNA+and+Cytochrome+C&rft.au=Tanaka%2C+Mikiei%3BChock%2C+P+Boon%3BStadtman%2C+Earl&rft.aulast=Tanaka&rft.aufirst=Mikiei&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photo-Induced Reactive Oxygen Species Generation and Cytotoxicity of different Water-Soluble Fullerenes in Human HaCaT Keratinocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40706536; 4755815 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Zhao, Baozhong AU - Bilski, Piotr AU - He, Yu-Ying AU - Feng, Li AU - Chignell, Colin Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Reactive oxygen species KW - Cytotoxicity KW - Keratinocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Photo-Induced+Reactive+Oxygen+Species+Generation+and+Cytotoxicity+of+different+Water-Soluble+Fullerenes+in+Human+HaCaT+Keratinocytes&rft.au=Zhao%2C+Baozhong%3BBilski%2C+Piotr%3BHe%2C+Yu-Ying%3BFeng%2C+Li%3BChignell%2C+Colin&rft.aulast=Zhao&rft.aufirst=Baozhong&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Inflammation and Cancer: Influence of Nitric Oxide T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705550; 4755883 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Hussain, S Perwez AU - He, Peijun AU - Subleski, Jeffery AU - Hofseth, Lorne AU - Trivers, Glennwood AU - Mechanic, Leah AU - Bailey, Anne AU - Bernard, Mark AU - Schwank, Jonathan AU - Djurickovic, Draginja AU - Haines, Diana AU - Weiss, Jonathan AU - Laubach, Victor AU - Back, Timothy AU - Wiltrout, Robert AU - Harris, Curtis Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cancer KW - Nitric oxide KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705550?accountid=14244 L2 - 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ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mitochondrially-Targeted Redox Agent Mitoquinone Enhances Doxorubicin-Induced Toxicity to Breast Cancer Cells While Protecting Cardiac Myocytes T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705413; 4755903 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Rao, V Ashutosh AU - Klein, Sarah AU - Zielonka, Jacek AU - Kalyanaraman, B AU - Shacter, Emily Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Toxicity KW - Breast cancer KW - Cardiomyocytes KW - Mitochondria KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705413?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=The+Mitochondrially-Targeted+Redox+Agent+Mitoquinone+Enhances+Doxorubicin-Induced+Toxicity+to+Breast+Cancer+Cells+While+Protecting+Cardiac+Myocytes&rft.au=Rao%2C+V+Ashutosh%3BKlein%2C+Sarah%3BZielonka%2C+Jacek%3BKalyanaraman%2C+B%3BShacter%2C+Emily&rft.aulast=Rao&rft.aufirst=V&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free Radical Production by Arsenic Trioxide T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40705118; 4755919 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Kadiiska, Maria AU - Liu, Jie AU - Waalkes, Mike AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Arsenic trioxide KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Free+Radical+Production+by+Arsenic+Trioxide&rft.au=Kadiiska%2C+Maria%3BLiu%2C+Jie%3BWaalkes%2C+Mike%3BMason%2C+Ronald&rft.aulast=Kadiiska&rft.aufirst=Maria&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascorbic Acid as a Pro-Oxidant Therapeutic Agent in Cancer T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704873; 4755912 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Chen, Qi AU - Sun, Andrew AU - Espey, Michael AU - Levine, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Cancer KW - Ascorbic acid KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Ascorbic+Acid+as+a+Pro-Oxidant+Therapeutic+Agent+in+Cancer&rft.au=Chen%2C+Qi%3BSun%2C+Andrew%3BEspey%2C+Michael%3BLevine%2C+Mark&rft.aulast=Chen&rft.aufirst=Qi&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Guanosine Monophosphate, but not Guanosine and its Higher Phosphate Congeners, Mediates Heme-Periphery Electron Transfers in Lactoperoxidase T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704235; 4755470 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bonini, Marcelo AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Phosphate KW - Guanosine KW - Congeners KW - Electron transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Guanosine+Monophosphate%2C+but+not+Guanosine+and+its+Higher+Phosphate+Congeners%2C+Mediates+Heme-Periphery+Electron+Transfers+in+Lactoperoxidase&rft.au=Bonini%2C+Marcelo%3BMason%2C+Ronald&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electron Transfer between a Tyrosyl Radical and a Cysteine Residue in Hemoproteins: Spin Trapping Analysis T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704111; 4755439 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bhattacharjee, Suchandra AU - Deterding, Leesa AU - Jiang, Jinjie AU - Bonini, Marcello AU - Tomer, Kenneth AU - Ramirez, Dario AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Residues KW - Radicals KW - Trapping KW - Cysteine KW - Electron transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Electron+Transfer+between+a+Tyrosyl+Radical+and+a+Cysteine+Residue+in+Hemoproteins%3A+Spin+Trapping+Analysis&rft.au=Bhattacharjee%2C+Suchandra%3BDeterding%2C+Leesa%3BJiang%2C+Jinjie%3BBonini%2C+Marcello%3BTomer%2C+Kenneth%3BRamirez%2C+Dario%3BMason%2C+Ronald&rft.aulast=Bhattacharjee&rft.aufirst=Suchandra&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Radical Sites in M. Tuberculosis Katg Identified using Epr Spectroscopy, the 3-D Crystal Structure and Electron-Transfer Couplings T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40704094; 4755485 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Ranguelova, Kalina AU - Suarez, Javier AU - Gerfen, Gary AU - Magliozzo, Richard Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Spectroscopy KW - Tuberculosis KW - Radicals KW - Crystal structure KW - Mycobacterium tuberculosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Radical+Sites+in+M.+Tuberculosis+Katg+Identified+using+Epr+Spectroscopy%2C+the+3-D+Crystal+Structure+and+Electron-Transfer+Couplings&rft.au=Ranguelova%2C+Kalina%3BSuarez%2C+Javier%3BGerfen%2C+Gary%3BMagliozzo%2C+Richard&rft.aulast=Ranguelova&rft.aufirst=Kalina&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Photocytotoxicity and Photochemistry of the Selective Non-Steroidal Androgen Receptor Modulator Tdpq T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40703473; 4755818 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bilski, Piotr AU - Risek, Boris AU - Chignell, Colin AU - Schrade, William Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Photochemistry KW - Androgen receptors KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40703473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Photocytotoxicity+and+Photochemistry+of+the+Selective+Non-Steroidal+Androgen+Receptor+Modulator+Tdpq&rft.au=Bilski%2C+Piotr%3BRisek%2C+Boris%3BChignell%2C+Colin%3BSchrade%2C+William&rft.aulast=Bilski&rft.aufirst=Piotr&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Dependent Nitrite Metabolism and NO Production is Regulated by Oxygen T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40703095; 4755765 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Shiva, Sruti AU - Curtis, Erin AU - Liu, Geng AU - Gladwin, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Nitrite KW - Oxygen KW - Metabolism KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40703095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Tissue+Dependent+Nitrite+Metabolism+and+NO+Production+is+Regulated+by+Oxygen&rft.au=Shiva%2C+Sruti%3BCurtis%2C+Erin%3BLiu%2C+Geng%3BGladwin%2C+Mark&rft.aulast=Shiva&rft.aufirst=Sruti&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Procainamide, but not N-Acetylprocainamide, Induces Protein Free Radical Formation on Myeloperoxidase: A Potential Mechanism of Agranulocytosis. T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40699004; 4755737 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Siraki, Arno AU - Bonini, Marcelo AU - Jiang, JinJie AU - Ehrenshaft, Marilyn AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Free radicals KW - Neutropenia KW - Peroxidase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Procainamide%2C+but+not+N-Acetylprocainamide%2C+Induces+Protein+Free+Radical+Formation+on+Myeloperoxidase%3A+A+Potential+Mechanism+of+Agranulocytosis.&rft.au=Siraki%2C+Arno%3BBonini%2C+Marcelo%3BJiang%2C+JinJie%3BEhrenshaft%2C+Marilyn%3BMason%2C+Ronald&rft.aulast=Siraki&rft.aufirst=Arno&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inducible Nitric Oxide Synthase Overexpression in Diabetic Target Organs Triggers Increased Lipid Peroxidation and Tissue Damage T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698391; 4755662 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Stadler, Krisztian AU - Bonini, Marcelo AU - Dallas, Shannon AU - Radi, Rafael AU - Mason, Ronald AU - Kadiiska, Maria Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Peroxidation KW - Organs KW - Lipid peroxidation KW - Nitric-oxide synthase KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Inducible+Nitric+Oxide+Synthase+Overexpression+in+Diabetic+Target+Organs+Triggers+Increased+Lipid+Peroxidation+and+Tissue+Damage&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo%3BDallas%2C+Shannon%3BRadi%2C+Rafael%3BMason%2C+Ronald%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superoxide Levels and Mitochondrial Function are Regulated by SIRT3 Kristi T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698297; 4755645 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Jacobs, Muldoon AU - Gius, David Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Mitochondria KW - Superoxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Superoxide+Levels+and+Mitochondrial+Function+are+Regulated+by+SIRT3+Kristi&rft.au=Jacobs%2C+Muldoon%3BGius%2C+David&rft.aulast=Jacobs&rft.aufirst=Muldoon&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Key Role of Inducible Nitric Oxide Synthase in Free Radical Production and Protein Oxidation Induced by Ketosis T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698249; 4755661 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Stadler, Krisztian AU - Bonini, Marcelo AU - Mason, Ronald AU - Kadiiska, Maria Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Oxidation KW - Nitric-oxide synthase KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Key+Role+of+Inducible+Nitric+Oxide+Synthase+in+Free+Radical+Production+and+Protein+Oxidation+Induced+by+Ketosis&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo%3BMason%2C+Ronald%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Radical View of Cu, Zn-Superoxide Dismutase-Driven Oxidations: Copper- and Carbonate Radical Anion-Triggered Protein Radical Chemistry T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40698156; 4755736 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Ramirez, Dario AU - Gomez-Mejiba, Sandra AU - Corbett, Jean AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Oxidation KW - Radicals KW - Carbonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=A+Radical+View+of+Cu%2C+Zn-Superoxide+Dismutase-Driven+Oxidations%3A+Copper-+and+Carbonate+Radical+Anion-Triggered+Protein+Radical+Chemistry&rft.au=Ramirez%2C+Dario%3BGomez-Mejiba%2C+Sandra%3BCorbett%2C+Jean%3BMason%2C+Ronald&rft.aulast=Ramirez&rft.aufirst=Dario&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Testing the Hypothesis that "Methionine Residues in Proteins are Antioxidants" T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695981; 4755731 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Luo, Shen AU - Levine, Rodney Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Residues KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Testing+the+Hypothesis+that+%22Methionine+Residues+in+Proteins+are+Antioxidants%22&rft.au=Luo%2C+Shen%3BLevine%2C+Rodney&rft.aulast=Luo&rft.aufirst=Shen&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutive Nitric Oxide Synthase Activation is a Significant Route Mediating Nitroglycerin-Induced Vasodilation T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695746; 4755656 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Bonini, Marcelo AU - Stadler, Krisztian AU - Silva, Sueli AU - Corbett, Jean AU - Dore, Michael AU - Petranka, John AU - Duma, Danielle AU - Fernandes, Denise AU - Tanaka, Leonardo AU - Laurindo, Francisco AU - Mason, Ronald Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Nitric-oxide synthase KW - Vasodilation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Constitutive+Nitric+Oxide+Synthase+Activation+is+a+Significant+Route+Mediating+Nitroglycerin-Induced+Vasodilation&rft.au=Bonini%2C+Marcelo%3BStadler%2C+Krisztian%3BSilva%2C+Sueli%3BCorbett%2C+Jean%3BDore%2C+Michael%3BPetranka%2C+John%3BDuma%2C+Danielle%3BFernandes%2C+Denise%3BTanaka%2C+Leonardo%3BLaurindo%2C+Francisco%3BMason%2C+Ronald&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascorbate Transporter SLC23A1 is Essential for Vitamin C Renal Reabsorption and Mediates Tight Control In Vivo T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695458; 4755552 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Tu, Hongbin AU - Corpe, Christopher AU - Wang, Jin AU - Eck, Peter AU - Wang, Yaohui AU - Espey, Michael AU - Faulhaber-Walter, Robert AU - Schnermann, Jurgen AU - Nussbaum, Robert AU - Levine, Mark Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Vitamin C KW - Ascorbic acid KW - Reabsorption KW - Kidneys KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Ascorbate+Transporter+SLC23A1+is+Essential+for+Vitamin+C+Renal+Reabsorption+and+Mediates+Tight+Control+In+Vivo&rft.au=Tu%2C+Hongbin%3BCorpe%2C+Christopher%3BWang%2C+Jin%3BEck%2C+Peter%3BWang%2C+Yaohui%3BEspey%2C+Michael%3BFaulhaber-Walter%2C+Robert%3BSchnermann%2C+Jurgen%3BNussbaum%2C+Robert%3BLevine%2C+Mark&rft.aulast=Tu&rft.aufirst=Hongbin&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specificity of Carbonylated Proteins in E. Coli under Certain Nutrient Conditions: Proteomic Identification T2 - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AN - 40695142; 4755729 JF - 14th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2007) AU - Noda, Yasuko AU - Berlett, Barbara AU - Stadtman, Earl AU - Aponte, Angel AU - Morgan, Meghan AU - Shen, Rong-Fong Y1 - 2007/11/14/ PY - 2007 DA - 2007 Nov 14 KW - Carbonyl compounds KW - Nutrients KW - Proteomics KW - Specificity KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.atitle=Specificity+of+Carbonylated+Proteins+in+E.+Coli+under+Certain+Nutrient+Conditions%3A+Proteomic+Identification&rft.au=Noda%2C+Yasuko%3BBerlett%2C+Barbara%3BStadtman%2C+Earl%3BAponte%2C+Angel%3BMorgan%2C+Meghan%3BShen%2C+Rong-Fong&rft.aulast=Noda&rft.aufirst=Yasuko&rft.date=2007-11-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2007/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Blood gene expression signatures predict exposure levels. AN - 68504838; 17984051 AB - To respond to potential adverse exposures properly, health care providers need accurate indicators of exposure levels. The indicators are particularly important in the case of acetaminophen (APAP) intoxication, the leading cause of liver failure in the U.S. We hypothesized that gene expression patterns derived from blood cells would provide useful indicators of acute exposure levels. To test this hypothesis, we used a blood gene expression data set from rats exposed to APAP to train classifiers in two prediction algorithms and to extract patterns for prediction using a profiling algorithm. Prediction accuracy was tested on a blinded, independent rat blood test data set and ranged from 88.9% to 95.8%. Genomic markers outperformed predictions based on traditional clinical parameters. The expression profiles of the predictor genes from the patterns extracted from the blood exhibited remarkable (97% accuracy) transtissue APAP exposure prediction when liver gene expression data were used as a test set. Analysis of human samples revealed separation of APAP-intoxicated patients from control individuals based on blood expression levels of human orthologs of the rat discriminatory genes. The major biological signal in the discriminating genes was activation of an inflammatory response after exposure to toxic doses of APAP. These results support the hypothesis that gene expression data from peripheral blood cells can provide valuable information about exposure levels, well before liver damage is detected by classical parameters. It also supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Bushel, P R AU - Heinloth, A N AU - Li, J AU - Huang, L AU - Chou, J W AU - Boorman, G A AU - Malarkey, D E AU - Houle, C D AU - Ward, S M AU - Wilson, R E AU - Fannin, R D AU - Russo, M W AU - Watkins, P B AU - Tennant, R W AU - Paules, R S AD - Biostatistics Branch, Environmental Stress and Cancer Group, Environmental Toxicology Program, Microarray Group, **Cancer Biology Group, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709. Y1 - 2007/11/13/ PY - 2007 DA - 2007 Nov 13 SP - 18211 EP - 18216 VL - 104 IS - 46 KW - Acetaminophen KW - 362O9ITL9D KW - L-Iditol 2-Dehydrogenase KW - EC 1.1.1.14 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Alanine Transaminase -- metabolism KW - Algorithms KW - L-Iditol 2-Dehydrogenase -- metabolism KW - Male KW - Leukocyte Count KW - Blood KW - Gene Expression KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68504838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Blood+gene+expression+signatures+predict+exposure+levels.&rft.au=Bushel%2C+P+R%3BHeinloth%2C+A+N%3BLi%2C+J%3BHuang%2C+L%3BChou%2C+J+W%3BBoorman%2C+G+A%3BMalarkey%2C+D+E%3BHoule%2C+C+D%3BWard%2C+S+M%3BWilson%2C+R+E%3BFannin%2C+R+D%3BRusso%2C+M+W%3BWatkins%2C+P+B%3BTennant%2C+R+W%3BPaules%2C+R+S&rft.aulast=Bushel&rft.aufirst=P&rft.date=2007-11-13&rft.volume=104&rft.issue=46&rft.spage=18211&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=1091-6490&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE5652; GEO N1 - SuppNotes - Cited By: Cell. 2000 Jul 7;102(1):109-26 [10929718] Toxicol Pathol. 2006;34(7):921-8 [17178692] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] Digestion. 2003;67(3):138-45 [12853725] Rofo. 2003 Aug;175(8):1112-9 [12886481] Exp Mol Pathol. 2003 Dec;75(3):187-93 [14611809] Bioinformatics. 2004 Jul 10;20(10):1535-45 [14962920] Eur J Gastroenterol Hepatol. 2005 Feb;17(2):141-3 [15674089] Bioinformatics. 2005 Mar 1;21(5):631-43 [15374862] Physiol Genomics. 2005 Mar 21;21(1):92-104 [15781589] J Bioinform Comput Biol. 2005 Apr;3(2):225-41 [15852502] Clin Ther. 2005 Mar;27(3):336-41 [15878387] Bioinformatics. 2005 Aug 1;21(15):3301-7 [15905277] Liver Transpl. 2005 Nov;(11 Suppl 2):S30-4 [16237684] Environ Health Perspect. 2006 Apr;114(4):553-9 [16581545] JAMA. 2006 Jul 5;296(1):87-93 [16820551] Toxicol Pathol. 2006;34(6):795-801 [17162537] Toxicol Lett. 2001 Mar 31;120(1-3):317-21 [11323190] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Urban Environment and Human Environmental Health: Public Participation in Environmental Health Research. T2 - 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America AN - 40753386; 4778967 JF - 28th Annual Meeting of the Society of Environmental Toxicology and Chemistry North America AU - Olden, K Y1 - 2007/11/11/ PY - 2007 DA - 2007 Nov 11 KW - Environmental health KW - Urban areas KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40753386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+North+America&rft.atitle=Urban+Environment+and+Human+Environmental+Health%3A+Public+Participation+in+Environmental+Health+Research.&rft.au=Olden%2C+K&rft.aulast=Olden&rft.aufirst=K&rft.date=2007-11-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+Meeting+of+the+Society+of+Environmental+Toxicology+and+Chemistry+North+America&rft.issn=&rft_id=info:doi/ L2 - http://milwaukee.setac.org/pdf/2007_Abstract_Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second cancers among 104,760 survivors of cervical cancer: evaluation of long-term risk. AN - 68486505; 17971527 AB - Given the extended survival of patients diagnosed with cervical cancer, the large number of these women treated with radiotherapy, and the presence in this population of established cancer risk factors such as human papillomavirus (HPV) infection and cigarette smoking, it is important to clarify long-term trends in second cancer risk. Using data from 104,760 one-year survivors of cervical cancer reported to 13 population-based cancer registries in Denmark, Finland, Norway, Sweden, and the United States, we calculated standardized incidence ratios (SIRs) for second cancers overall and cancers at particular sites among women with cervical cancer, including cervical cancer patients who were treated or not treated with radiation, over more than 40 years of follow-up. Cox regression models were used to assess the time-varying association of radiotherapy with risk of second cancers and to assess the interaction of radiation treatment with age at diagnosis. All statistical tests were two-sided. Among 104,760 one-year survivors of cervical cancer, the risk of all second cancers taken together was increased to a statistically significant extent (n = 12,496; SIR = 1.30; 95% confidence interval [CI] = 1.28 to 1.33). Compared with the general population, in both radiotherapy (N = 52,613) and no-radiotherapy groups (N = 27,382), risks for HPV-related cancers (of the pharynx, genital sites, and rectum/anus) and smoking-related cancers (of the pharynx, trachea/bronchus/lung, pancreas, and urinary bladder) were elevated to a statistically significant extent. Cervical cancer patients treated with radiotherapy, but not those who did not receive radiotherapy, were at increased risk for all second cancers and cancers at heavily irradiated sites (colon, rectum/anus, urinary bladder, ovary, and genital sites) beyond 40 years of follow-up compared with women in the general population. The association of radiotherapy with second cancer risk was modified by age at cervical cancer diagnosis for rectum/anus, genital sites, and urinary bladder, with higher hazard ratios for second cancer at younger ages of cervical cancer. After adjustment for competing mortality, the 40-year cumulative risk of any second cancer was higher among women diagnosed with cervical cancer before age 50 (22.2%; 95% CI = 21.5% to 22.8%) than among women diagnosed after age 50 (16.4%; 95% CI = 16.1% to 16.9%). Cervical cancer patients treated with radiotherapy are at increased risk of second cancers at sites in close proximity to the cervix beyond 40 years of follow-up. JF - Journal of the National Cancer Institute AU - Chaturvedi, Anil K AU - Engels, Eric A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Storm, Hans AU - Lynch, Charles F AU - Hall, Per AU - Langmark, Froydis AU - Pukkala, Eero AU - Kaijser, Magnus AU - Andersson, Michael AU - Fosså, Sophie D AU - Joensuu, Heikki AU - Boice, John D AU - Kleinerman, Ruth A AU - Travis, Lois B AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA. chaturva@mail.nih.gov Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1634 EP - 1643 VL - 99 IS - 21 KW - Index Medicus KW - Odds Ratio KW - Age Factors KW - Humans KW - Linear Models KW - SEER Program KW - Tumor Virus Infections -- epidemiology KW - Aged KW - Smoking -- epidemiology KW - Risk Assessment KW - Papillomavirus Infections -- epidemiology KW - Adult KW - Papillomavirus Infections -- complications KW - Smoking -- adverse effects KW - Radiotherapy -- adverse effects KW - Registries KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Middle Aged KW - Follow-Up Studies KW - United States -- epidemiology KW - Finland -- epidemiology KW - Scandinavian and Nordic Countries -- epidemiology KW - Female KW - Proportional Hazards Models KW - Tumor Virus Infections -- complications KW - Survivors -- statistics & numerical data KW - Neoplasms, Second Primary -- epidemiology KW - Uterine Cervical Neoplasms -- epidemiology KW - Neoplasms, Second Primary -- etiology KW - Uterine Cervical Neoplasms -- radiotherapy KW - Neoplasms, Second Primary -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68486505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+cancers+among+104%2C760+survivors+of+cervical+cancer%3A+evaluation+of+long-term+risk.&rft.au=Chaturvedi%2C+Anil+K%3BEngels%2C+Eric+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BStorm%2C+Hans%3BLynch%2C+Charles+F%3BHall%2C+Per%3BLangmark%2C+Froydis%3BPukkala%2C+Eero%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BFoss%C3%A5%2C+Sophie+D%3BJoensuu%2C+Heikki%3BBoice%2C+John+D%3BKleinerman%2C+Ruth+A%3BTravis%2C+Lois+B&rft.aulast=Chaturvedi&rft.aufirst=Anil&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1634&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Natl Cancer Inst. 2008 Apr 16;100(8):600; author reply 600-1 [18398096] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Chitosan Solution, a Novel Adjuvant/Depot for Subcutaneous Vaccination, Enhances Both Humoral and Cell-Mediated Immune Responses. T2 - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AN - 40739142; 4770405 JF - Second International Conference on Modern Vaccine / Adjuvant Formulation (MVAF 2007) AU - Greiner, John W AU - Rogers, Connie J AU - Hance, Kenneth W AU - Schlom, Jeffrey AU - Zaharoff, David A Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 KW - Vaccination KW - Chitosan KW - Adjuvants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40739142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.atitle=Chitosan+Solution%2C+a+Novel+Adjuvant%2FDepot+for+Subcutaneous+Vaccination%2C+Enhances+Both+Humoral+and+Cell-Mediated+Immune+Responses.&rft.au=Greiner%2C+John+W%3BRogers%2C+Connie+J%3BHance%2C+Kenneth+W%3BSchlom%2C+Jeffrey%3BZaharoff%2C+David+A&rft.aulast=Greiner&rft.aufirst=John&rft.date=2007-11-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Second+International+Conference+on+Modern+Vaccine+%2F+Adjuvant+Formulation+%28MVAF+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.meetingsmanagement.com/mvaf_2007/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prospective Study of Serum Vitamin D and Cancer Mortality in the United States AN - 20373976; 7743532 AB - BACKGROUND: Vitamin D has been hypothesized to reduce cancer mortality through its effects on incidence and/or survival. Epidemiologic studies of the association of 25-hydroxyvitamin D [25(OH)D] and the risk of cancer, however, have been largely limited to incident cancers at a few sites. METHODS: A total of 16818 participants in the Third National Health and Nutrition Examination Survey who were 17 years or older at enrollment were followed from 1988-1994 through 2000. Levels of serum 25(OH)D were measured at baseline by radioimmunoassay. Cox proportional hazards regression models were used to examine the relationship between serum 25(OH)D levels and total cancer mortality (in the entire population or according to race/ethnicity, sex, age, and retinol status) and mortality from specific cancers. Because serum was collected in the south in cooler months and the north in warmer months, we examined associations by collection season. All statistical tests were two-sided. RESULTS: We identified 536 cancer deaths in 146578 person-years. Total cancer mortality was unrelated to baseline vitamin D status in the entire population, men, women, non-Hispanic whites, non-Hispanic blacks, Mexican Americans, and in persons younger than 70 or 70 years or older. We found no interaction between vitamin D and season or vitamin D and serum retinol. Colorectal cancer mortality was inversely related to serum 25(OH)D level, with levels 80 nmol/L or higher associated with a 72% risk reduction (95% confidence interval = 32% to 89%) compared with lower than 50 nmol/L, P sub(trend) = .02. CONCLUSIONS: Our results do not support an association between 25(OH)D and total cancer mortality, although there was an inverse relationship between 25(OH)D levels and colorectal cancer mortality. JF - Journal of the National Cancer Institute AU - Freedman, DMichal AU - Looker, Anne C AU - Chang, Shih-Chen AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (DMF, SCC, BIG) Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 1594 EP - 1602 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 21 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - risk reduction KW - USA KW - Age KW - vitamins KW - survival KW - Nutrition KW - Cancer KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Prospective+Study+of+Serum+Vitamin+D+and+Cancer+Mortality+in+the+United+States&rft.au=Freedman%2C+DMichal%3BLooker%2C+Anne+C%3BChang%2C+Shih-Chen%3BGraubard%2C+Barry+I&rft.aulast=Freedman&rft.aufirst=DMichal&rft.date=2007-11-07&rft.volume=99&rft.issue=21&rft.spage=1594&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - risk reduction; Mortality; Age; vitamins; survival; Nutrition; Ethnic groups; Cancer; USA ER - TY - JOUR T1 - Cause-Specific Excess Deaths Associated With Underweight, Overweight, and Obesity AN - 20371567; 7741610 AB - CONTEXT: The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population. OBJECTIVE: To estimate cause-specific excess deaths associated with underweight (BMI <18.5), overweight (BMI 25-<30), and obesity (BMI greater than or equal to 30). Design, Setting, and Participants Cause-specific relative risks of mortality from the National Health and Nutrition Examination Survey (NHANES) I, 1971-1975; II, 1976-1980; and III, 1988-1994, with mortality follow-up through 2000 (571 042 person-years of follow-up) were combined with data on BMI and other covariates from NHANES 1999-2002 with underlying cause of death information for 2.3 million adults 25 years and older from 2004 vital statistics data for the United States. MAIN OUTCOME MEASURES: Cause-specific excess deaths in 2004 by BMI levels for categories of cardiovascular disease (CVD), cancer, and all other causes (noncancer, non-CVD causes). RESULTS: Based on total follow-up, underweight was associated with significantly increased mortality from noncancer, non-CVD causes (23 455 excess deaths; 95% confidence interval [CI], 11 848 to 35 061) but not associated with cancer or CVD mortality. Overweight was associated with significantly decreased mortality from noncancer, non-CVD causes (-69 299 excess deaths; 95% CI, -100 702 to -37 897) but not associated with cancer or CVD mortality. Obesity was associated with significantly increased CVD mortality (112 159 excess deaths; 95% CI, 87 842 to 136 476) but not associated with cancer mortality or with noncancer, non-CVD mortality. In further analyses, overweight and obesity combined were associated with increased mortality from diabetes and kidney disease (61 248 excess deaths; 95% CI, 49 685 to 72 811) and decreased mortality from other noncancer, non-CVD causes (-105 572 excess deaths; 95% CI, -161 816 to -49 328). Obesity was associated with increased mortality from cancers considered obesity-related (13 839 excess deaths; 95% CI, 1920 to 25 758) but not associated with mortality from other cancers. Comparisons across surveys suggested a decrease in the association of obesity with CVD mortality over time. CONCLUSIONS: The BMI-mortality association varies by cause of death. These results help to clarify the associations of BMI with all-cause mortality. JF - JAMA: Journal of the American Medical Association AU - Flegal, Katherine M AU - Graubard, Barry I AU - Williamson, David F AU - Gail, Mitchell H AD - National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville (Dr Flegal) and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda (Drs Graubard and Gail), Maryland Y1 - 2007/11/07/ PY - 2007 DA - 2007 Nov 07 SP - 2028 EP - 2037 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 298 IS - 17 SN - 0098-7484, 0098-7484 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Death KW - Statistics KW - Body mass KW - obesity KW - Health KW - Adults KW - Nutrition KW - Evaluation KW - diabetes mellitus KW - body mass KW - Cardiorespiratory KW - Diseases KW - vital statistics KW - Mortality KW - Obesity KW - Gerontology KW - Surveys KW - Kidneys KW - Cancer KW - Diabetes KW - USA KW - Analysis KW - Kidney KW - AMA KW - Cardiovascular diseases KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20371567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Cause-Specific+Excess+Deaths+Associated+With+Underweight%2C+Overweight%2C+and+Obesity&rft.au=Flegal%2C+Katherine+M%3BGraubard%2C+Barry+I%3BWilliamson%2C+David+F%3BGail%2C+Mitchell+H&rft.aulast=Flegal&rft.aufirst=Katherine&rft.date=2007-11-07&rft.volume=298&rft.issue=17&rft.spage=2028&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Death; Statistics; Body mass; Gerontology; Surveys; Health; Adults; Kidneys; Nutrition; Cancer; Diabetes; Evaluation; Analysis; AMA; Cardiorespiratory; Diseases; Mortality; diabetes mellitus; body mass; Kidney; obesity; Cardiovascular diseases; vital statistics; USA ER - TY - JOUR T1 - The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases. AN - 68453112; 17939684 AB - The wild-type p53-induced phosphatase Wip1 (PP2Cdelta or PPM1D) is a member of the protein phosphatase 2C (PP2C) family and controls cell cycle checkpoints in response to DNA damage. p38 MAPK and ATM were identified as physiological substrates of Wip1, and we previously reported a substrate motif that was defined using variants of the p38(180pT 182pY) diphosphorylated peptide, TDDEMpTGpYVAT. However, the substrate recognition motifs for Wip1 have not been fully defined as the sequences surrounding the targeted residues in ATM and p38 MAPK appear to be unrelated. Using a recombinant human Wip1 catalytic domain (rWip1), in this study we measured the kinetic parameters for variants of the ATM(1981pS) phosphopeptide, AFEEGpSQSTTI. We found that rWip1 dephosphorylates phosphoserine and phosphothreonine in the p(S/T)Q motif, which is an essential requirement for substrate recognition. In addition, acidic, hydrophobic, or aromatic amino acids surrounding the p(S/T)Q sequence have a positive influence, while basic amino acids have a negative influence on substrate dephosphorylation. The kinetic constants allow discrimination between true substrates and nonsubstrates of Wip1, and we identified several new putative substrates that include HDM2, SMC1A, ATR, and Wip1 itself. A three-dimensional molecular model of Wip1 with a bound substrate peptide and site-directed mutagenesis analyses suggested that the important residues for ATM(1981pS) substrate recognition are similar but not identical to those for the p38(180pT 182pY) substrate. Results from this study should be useful for predicting new physiological substrates that may be regulated by Wip1 and for developing selective anticancer drugs. JF - Biochemistry AU - Yamaguchi, Hiroshi AU - Durell, Stewart R AU - Chatterjee, Deb K AU - Anderson, Carl W AU - Appella, Ettore AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 12594 EP - 12603 VL - 46 IS - 44 SN - 0006-2960, 0006-2960 KW - Cell Cycle Proteins KW - 0 KW - DNA-Binding Proteins KW - Peptide Fragments KW - Recombinant Proteins KW - Tumor Suppressor Proteins KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - ATM protein, human KW - EC 2.7.11.1 KW - Ataxia Telangiectasia Mutated Proteins KW - Protein-Serine-Threonine Kinases KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - PPM1A protein, human KW - EC 3.1.3.16 KW - PPM1B protein, human KW - PPM1D protein, human KW - PPM1G protein, human KW - Phosphoprotein Phosphatases KW - Protein Phosphatase 2C KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Protein-Serine-Threonine Kinases -- metabolism KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Peptide Fragments -- chemistry KW - Amino Acid Motifs KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Tumor Suppressor Proteins -- metabolism KW - Substrate Specificity KW - Recombinant Proteins -- chemistry KW - Catalytic Domain -- physiology KW - DNA-Binding Proteins -- metabolism KW - Cell Cycle Proteins -- chemistry KW - Phosphoprotein Phosphatases -- physiology KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Phosphoprotein Phosphatases -- chemistry KW - Phosphatidylinositol 3-Kinases -- chemistry KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68453112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+Wip1+phosphatase+PPM1D+dephosphorylates+SQ%2FTQ+motifs+in+checkpoint+substrates+phosphorylated+by+PI3K-like+kinases.&rft.au=Yamaguchi%2C+Hiroshi%3BDurell%2C+Stewart+R%3BChatterjee%2C+Deb+K%3BAnderson%2C+Carl+W%3BAppella%2C+Ettore&rft.aulast=Yamaguchi&rft.aufirst=Hiroshi&rft.date=2007-11-06&rft.volume=46&rft.issue=44&rft.spage=12594&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-11 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasion AN - 20551814; 7745631 AB - Plasmodium falciparum invasion of human erythrocytes involves several parasite and erythrocyte receptors that enable parasite invasion by multiple redundant pathways. A key challenge to the development of effective vaccines that block parasite infection of erythrocytes is identifying the players in these pathways and determining their function. Invasion by the parasite clone, Dd2, requires sialic acid on the erythrocyte surface; Dd2/NM is a variant selected for its ability to invade neuraminidase-treated erythrocytes that lack sialic acid. The P. falciparum protein, reticulocyte homology 4 (PfRH4), is uniquely up-regulated in Dd2/NM compared with Dd2, suggesting that it may be a parasite receptor involved in invasion. The aim of the present study was to determine the role of PfRH4 in invasion of erythrocytes and to determine whether it is a target of antibody-mediated blockade and thus a vaccine candidate. We show that both native PfRH4 and a recombinant 30-kDa protein to a conserved region of PfRH4 (rRH4 sub(30)) bind strongly to neuraminidase-treated erythrocytes. rRH4 sub(30) blocks both the erythrocyte binding of the native PfRH4 and invasion of neuraminidase-treated erythrocytes by Dd2/NM. Taken together, these results indicate that PfRH4 is a parasite receptor involved in sialic acid-independent invasion of erythrocytes. Although antibodies to rRH4 sub(30) block binding of the native protein to erythrocytes, these antibodies failed to block invasion. These findings suggest that, although PfRH4 is required for invasion of neuraminidase-treated erythrocytes by Dd2/NM, it is inaccessible for antibody-mediated inhibition of the invasion process. JF - Proceedings of the National Academy of Sciences, USA AU - Gaur, Deepak AU - Singh, Sanjay AU - Singh, Subhash AU - Jiang, Lubin AU - Diouf, Ababacar AU - Miller, Louis H AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Twinbrook III, 12735 Twinbrook Parkway, Bethesda, MD 20892-8132 Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 17789 EP - 17794 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 45 SN - 0027-8424, 0027-8424 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Human diseases KW - Erythrocytes KW - Disease control KW - Malaria KW - Plasmodium falciparum KW - Infection KW - Public health KW - Antibodies KW - Homology KW - Vaccines KW - Reticulocytes KW - Sialic acids KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Recombinant+Plasmodium+falciparum+reticulocyte+homology+protein+4+binds+to+erythrocytes+and+blocks+invasion&rft.au=Gaur%2C+Deepak%3BSingh%2C+Sanjay%3BSingh%2C+Subhash%3BJiang%2C+Lubin%3BDiouf%2C+Ababacar%3BMiller%2C+Louis+H&rft.aulast=Gaur&rft.aufirst=Deepak&rft.date=2007-11-06&rft.volume=104&rft.issue=45&rft.spage=17789&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Antibodies; Human diseases; Erythrocytes; Disease control; Malaria; Vaccines; Public health; Homology; Infection; Reticulocytes; Sialic acids; Plasmodium falciparum ER - TY - JOUR T1 - Neural Substrates of Intermanual Transfer of a Newly Acquired Motor Skill AN - 20421354; 7768391 AB - In healthy humans, the two cerebral hemispheres show functional specialization to a degree unmatched in other animals, and such strong hemispheric specialization contributes to unimanual skill acquisition. When most humans learn a new motor skill with one hand, this process results in performance improvements in the opposite hand as well. Despite the obvious adaptive advantage of such intermanual transfer, there is no direct evidence identifying the neural substrates of this form of skill acquisition. Here, we used functional magnetic resonance imaging (fMRI) to study brain regions activated during intermanual transfer of a learned sequence of finger movements. First, we found that the supplementary motor area (SMA) has more activity when a skill has transferred well than when it has transferred poorly. Second, we found that fMRI activity in the ventrolateral posterior thalamic nucleus correlated with successful future intermanual transfer, whereas activity in the ventrolateral anterior thalamic nucleus correlated with past intermanual transfer. Third, we found that repetitive transcranial magnetic stimulation applied over the SMA blocked intermanual transfer without affecting skill acquisition. These findings provide direct evidence for an SMA-based mechanism that supports intermanual transfer of motor-skill learning. JF - Current Biology AU - Perez, MA AU - Tanaka, S AU - Wise, S P AU - Sadato, N AU - Tanabe, H C AU - Willingham, D T AU - Cohen, L G AD - Human Cortical Physiology Section and Stroke, Neurorehabilitation Clinic, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892-1430, USA, cohenl@ninds.nih.gov Y1 - 2007/11/06/ PY - 2007 DA - 2007 Nov 06 SP - 1896 EP - 1902 VL - 17 IS - 21 SN - 0960-9822, 0960-9822 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Hands KW - Brain mapping KW - Hemispheric laterality KW - supplementary motor area KW - Motor skills KW - Functional magnetic resonance imaging KW - Cerebral hemispheres KW - Brain KW - Hand KW - Specialization KW - Health KW - Thalamus KW - Finger KW - Fingers KW - Transfer learning KW - Transcranial magnetic stimulation KW - Scanning KW - Motor performance KW - Transfer of learning KW - Movement sequence KW - Stimuli KW - Motor skill learning KW - N3 11001:Behavioral and Cognitive Neuroscience KW - PE 080:Motor Learning UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20421354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Biology&rft.atitle=Neural+Substrates+of+Intermanual+Transfer+of+a+Newly+Acquired+Motor+Skill&rft.au=Perez%2C+MA%3BTanaka%2C+S%3BWise%2C+S+P%3BSadato%2C+N%3BTanabe%2C+H+C%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Perez&rft.aufirst=MA&rft.date=2007-11-06&rft.volume=17&rft.issue=21&rft.spage=1896&rft.isbn=&rft.btitle=&rft.title=Current+Biology&rft.issn=09609822&rft_id=info:doi/10.1016%2Fj.cub.2007.09.058 LA - English DB - Physical Education Index N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hands; Fingers; Scanning; Motor skills; Motor performance; Movement sequence; Transfer of learning; Brain; Stimuli; Health; Brain mapping; supplementary motor area; Hemispheric laterality; Transcranial magnetic stimulation; Transfer learning; Cerebral hemispheres; Functional magnetic resonance imaging; Specialization; Hand; Motor skill learning; Thalamus; Finger DO - http://dx.doi.org/10.1016/j.cub.2007.09.058 ER - TY - CPAPER T1 - Disruption of a Putative ABC Transporter in Plasmodium falciparum Alters Parasite Growth and Responses to Antimalarial Drugs T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40775387; 4777335 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Raj, Dipak K Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Parasites KW - Drugs KW - ABC transporter KW - Growth KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40775387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Disruption+of+a+Putative+ABC+Transporter+in+Plasmodium+falciparum+Alters+Parasite+Growth+and+Responses+to+Antimalarial+Drugs&rft.au=Raj%2C+Dipak+K&rft.aulast=Raj&rft.aufirst=Dipak&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endogenous Nitric Oxide Production in Intraerythrocytic Stages of the Malaria Parasite Plasmodium falciparum T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40767814; 4777268 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Ostera, Graciela R AU - Tokumasu, Fuyuki AU - Dvorak, James A Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Parasites KW - Malaria KW - Nitric oxide KW - Public health KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Endogenous+Nitric+Oxide+Production+in+Intraerythrocytic+Stages+of+the+Malaria+Parasite+Plasmodium+falciparum&rft.au=Ostera%2C+Graciela+R%3BTokumasu%2C+Fuyuki%3BDvorak%2C+James+A&rft.aulast=Ostera&rft.aufirst=Graciela&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lutzomyia longipalpis Salivary Recombinant Proteins Recognized by Human, Dog and Fox Antibodies T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40766834; 4777177 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gomes, Regis B AU - Collin, Nicolas AU - Teixeira, Clarissa AU - Jochim, Ryan AU - Elnaiem, Dia-eldin AU - Volf, Peter AU - Costa, Carlos AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Antibodies KW - Recombinants KW - Lutzomyia longipalpis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Lutzomyia+longipalpis+Salivary+Recombinant+Proteins+Recognized+by+Human%2C+Dog+and+Fox+Antibodies&rft.au=Gomes%2C+Regis+B%3BCollin%2C+Nicolas%3BTeixeira%2C+Clarissa%3BJochim%2C+Ryan%3BElnaiem%2C+Dia-eldin%3BVolf%2C+Peter%3BCosta%2C+Carlos%3BValenzuela%2C+Jesus+G&rft.aulast=Gomes&rft.aufirst=Regis&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lights, Camera, Action: A Method to Study Male Anopheles gambiae Mating Behavior in the Field T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40766258; 4777360 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Manoukis, Nicholas C AU - Diabate, Abdoulaye AU - Dao, Adama AU - Tokumasu, Fuyuki AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cameras KW - Mating behavior KW - Light effects KW - Aquatic insects KW - Reproductive behavior KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Lights%2C+Camera%2C+Action%3A+A+Method+to+Study+Male+Anopheles+gambiae+Mating+Behavior+in+the+Field&rft.au=Manoukis%2C+Nicholas+C%3BDiabate%2C+Abdoulaye%3BDao%2C+Adama%3BTokumasu%2C+Fuyuki%3BLehmann%2C+Tovi&rft.aulast=Manoukis&rft.aufirst=Nicholas&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Decision Tree Model for Estimating the Cost-Effectiveness of Rectal Artesunate Treatment for Severe Childhood Malaria at the Community Level T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40765371; 4777311 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Tozan, Yesim AU - Breman, Joel G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cost-benefit analysis KW - Children KW - Malaria KW - Artesunate KW - Models KW - Rectum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Decision+Tree+Model+for+Estimating+the+Cost-Effectiveness+of+Rectal+Artesunate+Treatment+for+Severe+Childhood+Malaria+at+the+Community+Level&rft.au=Tozan%2C+Yesim%3BBreman%2C+Joel+G&rft.aulast=Tozan&rft.aufirst=Yesim&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Two-Stage Model of Malaria Transmission and its Impact on the Spread of Resistance T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40765078; 4777310 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Smith, David L AU - Boni, Maciej AU - Klein, Eili AU - Laxminarayan, Ramanan Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Malaria KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Two-Stage+Model+of+Malaria+Transmission+and+its+Impact+on+the+Spread+of+Resistance&rft.au=Smith%2C+David+L%3BBoni%2C+Maciej%3BKlein%2C+Eili%3BLaxminarayan%2C+Ramanan&rft.aulast=Smith&rft.aufirst=David&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abundance of Immunomodulatory Proteins Revealed by Analysis of the Excretory-Secretory (E/S) Proteome of Brugia malayi T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764227; 4777437 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Bennuru, Sasisekhar AU - Semnani, Roshanak AU - Ribeiro, Jose M.C. AU - Meng, Zhaojing AU - Veenstra, Timothy D AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Abundance KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Abundance+of+Immunomodulatory+Proteins+Revealed+by+Analysis+of+the+Excretory-Secretory+%28E%2FS%29+Proteome+of+Brugia+malayi&rft.au=Bennuru%2C+Sasisekhar%3BSemnani%2C+Roshanak%3BRibeiro%2C+Jose+M.C.%3BMeng%2C+Zhaojing%3BVeenstra%2C+Timothy+D%3BNutman%2C+Thomas+B&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection of a Highly Sensitive Human Fecal Biomarker (10@@u-10@) IN = 10 ml Contaminated Drinking Water Samples using Immunomagnetic Separation T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764200; 4777515 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Sevilleja, Jesus Emmanuel A AU - Copeland, Curtis C AU - Guerrant, Richard L Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Bioindicators KW - Drinking water KW - Immunomagnetic separation KW - Biomarkers KW - Water pollution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Detection+of+a+Highly+Sensitive+Human+Fecal+Biomarker+%2810%40%40u-10%40%29+IN+%3D+10+ml+Contaminated+Drinking+Water+Samples+using+Immunomagnetic+Separation&rft.au=Sevilleja%2C+Jesus+Emmanuel+A%3BCopeland%2C+Curtis+C%3BGuerrant%2C+Richard+L&rft.aulast=Sevilleja&rft.aufirst=Jesus+Emmanuel&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Platform for Generating Conjugated Malarial Vaccines to Pseudomonas aeruginosa Exoprotein A T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40764059; 4777349 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Qian, Feng AU - Reiter, Karine AU - Zhang, Yanling AU - Shimp Jr, Richard L AU - Nguyen, Vu AU - Lebowitz, Jacob AU - Lambert, Lynn AU - Mullen, Gregory E AU - Martin, Laura B AU - Miller, Louis H AU - Narum, David L Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Disease control KW - Pseudomonas aeruginosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Platform+for+Generating+Conjugated+Malarial+Vaccines+to+Pseudomonas+aeruginosa+Exoprotein+A&rft.au=Qian%2C+Feng%3BReiter%2C+Karine%3BZhang%2C+Yanling%3BShimp+Jr%2C+Richard+L%3BNguyen%2C+Vu%3BLebowitz%2C+Jacob%3BLambert%2C+Lynn%3BMullen%2C+Gregory+E%3BMartin%2C+Laura+B%3BMiller%2C+Louis+H%3BNarum%2C+David+L&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of CpG on Stability of BSAM-1/Alhydrogel Formulation T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40763713; 4777346 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Zhu, Daming AU - Gebregeorgis, Elizabeth M AU - McClellan, Holly A AU - Huang, Shuhui AU - Miller, Louis H AU - Martin, Laura B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Effect+of+CpG+on+Stability+of+BSAM-1%2FAlhydrogel+Formulation&rft.au=Zhu%2C+Daming%3BGebregeorgis%2C+Elizabeth+M%3BMcClellan%2C+Holly+A%3BHuang%2C+Shuhui%3BMiller%2C+Louis+H%3BMartin%2C+Laura+B&rft.aulast=Zhu&rft.aufirst=Daming&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coexistent Filarial Infections Downregulate Antigen-Specific Th1 and Th17 Responses in Latent Tuberculosis: Association with Enhanced Expression of CTLA-4 and PD-1 T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40762721; 4777438 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Babu, Subash AU - Jayantasri, V AU - Rukmani, S AU - Kumaran, Paul AU - Gopi, P G AU - Sadacharam, K AU - Kumaraswami, V AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Tuberculosis KW - CTLA-4 protein KW - Lymphocytes T KW - PD-1 protein KW - Helper cells KW - Mycobacterium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Coexistent+Filarial+Infections+Downregulate+Antigen-Specific+Th1+and+Th17+Responses+in+Latent+Tuberculosis%3A+Association+with+Enhanced+Expression+of+CTLA-4+and+PD-1&rft.au=Babu%2C+Subash%3BJayantasri%2C+V%3BRukmani%2C+S%3BKumaran%2C+Paul%3BGopi%2C+P+G%3BSadacharam%2C+K%3BKumaraswami%2C+V%3BNutman%2C+Thomas+B&rft.aulast=Babu&rft.aufirst=Subash&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brugia malayi Microfilariae Inhibit IFNg and TNF-a in Response to Mycobacterium tuberculosis Infection in a Murine Coinfection Model T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40762618; 4777439 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Talaat, Kawsar R AU - Feng, Carl G AU - Scanga, Charles A AU - Mentink-Kane, Margaret M AU - White, Sandy AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Tuberculosis KW - Animal models KW - Tumor necrosis factor-a KW - Mycobacterium tuberculosis KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Brugia+malayi+Microfilariae+Inhibit+IFNg+and+TNF-a+in+Response+to+Mycobacterium+tuberculosis+Infection+in+a+Murine+Coinfection+Model&rft.au=Talaat%2C+Kawsar+R%3BFeng%2C+Carl+G%3BScanga%2C+Charles+A%3BMentink-Kane%2C+Margaret+M%3BWhite%2C+Sandy%3BNutman%2C+Thomas+B&rft.aulast=Talaat&rft.aufirst=Kawsar&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphism in the Gene Encoding Gambicin and Plasmodium falciparum Infection Susceptibility in Anopheles gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40761412; 4777630 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gonzalez-Cerdas, Rodrigo AU - Riehle, Michelle M AU - Vernick, Kenneth D AU - Hume, Jen AU - Ribeiro, Jose AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Gene polymorphism KW - Parasites KW - Aquatic insects KW - Pest control KW - Plasmodium falciparum KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Polymorphism+in+the+Gene+Encoding+Gambicin+and+Plasmodium+falciparum+Infection+Susceptibility+in+Anopheles+gambiae&rft.au=Gonzalez-Cerdas%2C+Rodrigo%3BRiehle%2C+Michelle+M%3BVernick%2C+Kenneth+D%3BHume%2C+Jen%3BRibeiro%2C+Jose%3BLehmann%2C+Tovi&rft.aulast=Gonzalez-Cerdas&rft.aufirst=Rodrigo&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Plasmodium falciparum Receptor BAEBL for Binding to Erythrocyte Ligand Glycophorin C T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760933; 4777269 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Jiang, Lubin AU - Duriseti, Sai AU - Sun, Peter AU - Miller, Louis H Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Erythrocytes KW - Glycophorin C KW - Parasites KW - Ligands KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760933?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Basis+of+Plasmodium+falciparum+Receptor+BAEBL+for+Binding+to+Erythrocyte+Ligand+Glycophorin+C&rft.au=Jiang%2C+Lubin%3BDuriseti%2C+Sai%3BSun%2C+Peter%3BMiller%2C+Louis+H&rft.aulast=Jiang&rft.aufirst=Lubin&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Swarm Segregation is the Main Mechanism that Prevents Mating between Sympatric Molecular Forms of Anopheles gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760821; 4777767 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Diabate, Abdoulaye AU - Dao, Adama AU - Yaro, Alpha S AU - Alpha, Adamou AU - Traore, S Cheick AU - Gonzalez, Rodrigo AU - Gwadz, Bob AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Sympatric populations KW - Mating KW - Swarms KW - Aquatic insects KW - Reproductive behavior KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Swarm+Segregation+is+the+Main+Mechanism+that+Prevents+Mating+between+Sympatric+Molecular+Forms+of+Anopheles+gambiae&rft.au=Diabate%2C+Abdoulaye%3BDao%2C+Adama%3BYaro%2C+Alpha+S%3BAlpha%2C+Adamou%3BTraore%2C+S+Cheick%3BGonzalez%2C+Rodrigo%3BGwadz%2C+Bob%3BLehmann%2C+Tovi&rft.aulast=Diabate&rft.aufirst=Abdoulaye&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Basis of Specificity and Cross Reactivity in Delayed-Type-Hypersensitivity Reactions to Bites of Sand Flies and Implication for Protection Against Leishmania Infection T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760391; 4777182 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Elnaiem, Dia-Eldin A AU - Oliveira, Luiz F AU - Gomes, Regis B AU - Toxeira, Clarissa AU - Subrahmanyam, Sreenath AU - Kamhawi, Shaden AU - Lawyer, Phillip G AU - Ward, Jerrold M AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Bites KW - Sand KW - Specificity KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760391?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Basis+of+Specificity+and+Cross+Reactivity+in+Delayed-Type-Hypersensitivity+Reactions+to+Bites+of+Sand+Flies+and+Implication+for+Protection+Against+Leishmania+Infection&rft.au=Elnaiem%2C+Dia-Eldin+A%3BOliveira%2C+Luiz+F%3BGomes%2C+Regis+B%3BToxeira%2C+Clarissa%3BSubrahmanyam%2C+Sreenath%3BKamhawi%2C+Shaden%3BLawyer%2C+Phillip+G%3BWard%2C+Jerrold+M%3BValenzuela%2C+Jesus+G&rft.aulast=Elnaiem&rft.aufirst=Dia-Eldin&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Eosinophils are not Required for Dec-Mediated Clearance of Microfilaremia T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760346; 4777176 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Klion, Amy D AU - Talaat, Kawsar AU - White, Sandy AU - Rosenberg, Helene AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Leukocytes (eosinophilic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Eosinophils+are+not+Required+for+Dec-Mediated+Clearance+of+Microfilaremia&rft.au=Klion%2C+Amy+D%3BTalaat%2C+Kawsar%3BWhite%2C+Sandy%3BRosenberg%2C+Helene%3BNutman%2C+Thomas+B&rft.aulast=Klion&rft.aufirst=Amy&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anopheles gambiae Gut Flora Dinamics and Microarray Analysis of Gut Gene Expression in Response to Bacteria T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40760125; 4777777 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Molina-Cruz, Alvaro AU - Leszczynski, Sara AU - Gupta, Lalita AU - Kumar, Sanjeev AU - DeJong, Randall AU - Ndikuyeze, Georges AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Flora KW - Digestive tract KW - Gene expression KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Anopheles+gambiae+Gut+Flora+Dinamics+and+Microarray+Analysis+of+Gut+Gene+Expression+in+Response+to+Bacteria&rft.au=Molina-Cruz%2C+Alvaro%3BLeszczynski%2C+Sara%3BGupta%2C+Lalita%3BKumar%2C+Sanjeev%3BDeJong%2C+Randall%3BNdikuyeze%2C+Georges%3BBarillas-Mury%2C+Carolina&rft.aulast=Molina-Cruz&rft.aufirst=Alvaro&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mononeme: A New Secretory Organelle in P. falciparum Merozoites Identified by Localization of Rhomboid-1 Protease T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759472; 4777817 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Singh, Subhash AU - Plassmeyer, Matthew AU - Gaur, Deepak AU - Miller, Louis Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Proteinase KW - Organelles KW - Merozoites KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Mononeme%3A+A+New+Secretory+Organelle+in+P.+falciparum+Merozoites+Identified+by+Localization+of+Rhomboid-1+Protease&rft.au=Singh%2C+Subhash%3BPlassmeyer%2C+Matthew%3BGaur%2C+Deepak%3BMiller%2C+Louis&rft.aulast=Singh&rft.aufirst=Subhash&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={15F7A93A -D47A-42C5-825A-0520A3323FD2}&AKey={F80697F6-E207-4950-99FC-3AE41F9B 4B10} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunity to Saliva at the Tick-Host Interface: Identification of Ixodes scapularis Salivary Proteins Eliciting a Cellular Immune Response T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759409; 4777800 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Anderson, Jennifer M AU - Miller, Nathan J AU - Mather, Thomas N AU - Ward, Jerrold M AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Immune response KW - Immunity KW - Saliva KW - Defense mechanisms KW - Ixodes scapularis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Immunity+to+Saliva+at+the+Tick-Host+Interface%3A+Identification+of+Ixodes+scapularis+Salivary+Proteins+Eliciting+a+Cellular+Immune+Response&rft.au=Anderson%2C+Jennifer+M%3BMiller%2C+Nathan+J%3BMather%2C+Thomas+N%3BWard%2C+Jerrold+M%3BValenzuela%2C+Jesus+G&rft.aulast=Anderson&rft.aufirst=Jennifer&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Identification of Wolbachia from the Filarial Nematode Mansonella perstans T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40759042; 4777825 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Kubofcik, Joseph AU - Keiser, Paul AU - Coulibaly, Yaya AU - Klion, Amy D AU - Traore', Sekou AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Nematodes KW - Wolbachia KW - Nematoda KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40759042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Identification+of+Wolbachia+from+the+Filarial+Nematode+Mansonella+perstans&rft.au=Kubofcik%2C+Joseph%3BKeiser%2C+Paul%3BCoulibaly%2C+Yaya%3BKlion%2C+Amy+D%3BTraore%27%2C+Sekou%3BNutman%2C+Thomas+B&rft.aulast=Kubofcik&rft.aufirst=Joseph&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={15F7A93A -D47A-42C5-825A-0520A3323FD2}&AKey={F80697F6-E207-4950-99FC-3AE41F9B 4B10} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microfilaria Positivity Modulates the Expression of FCER1-A on Monocytes in Filaria-Infected Patients T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40757661; 4777699 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Steel, Cathy AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Monocytes KW - Filarioidea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Microfilaria+Positivity+Modulates+the+Expression+of+FCER1-A+on+Monocytes+in+Filaria-Infected+Patients&rft.au=Steel%2C+Cathy%3BNutman%2C+Thomas+B&rft.aulast=Steel&rft.aufirst=Cathy&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immune Responsive Serine Protease from Anopheles gambiae Promotes Plasmodium falciparum Development T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40757278; 4777639 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Rodrigues, Janneth AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Serine proteinase KW - Parasites KW - Aquatic insects KW - Plasmodium falciparum KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40757278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Immune+Responsive+Serine+Protease+from+Anopheles+gambiae+Promotes+Plasmodium+falciparum+Development&rft.au=Rodrigues%2C+Janneth%3BBarillas-Mury%2C+Carolina&rft.aulast=Rodrigues&rft.aufirst=Janneth&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A DNA Vaccine Encoding a Sand Fly Salivary Yellow Related Protein (LJM11) Confers Protection Against Challenge with L. major in the Presence of L. longipalpis Salivary Gland Homogenate T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40756009; 4777793 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Oliveira, Luiz F AU - Gomes, 5Regis B. AU - Kamhawi, Shaden AU - Teixeira, Clarissa AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Sand KW - DNA vaccines KW - Salivary gland KW - Glands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+DNA+Vaccine+Encoding+a+Sand+Fly+Salivary+Yellow+Related+Protein+%28LJM11%29+Confers+Protection+Against+Challenge+with+L.+major+in+the+Presence+of+L.+longipalpis+Salivary+Gland+Homogenate&rft.au=Oliveira%2C+Luiz+F%3BGomes%2C+5Regis+B.%3BKamhawi%2C+Shaden%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Oliveira&rft.aufirst=Luiz&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Secreted Anopheles Midgut Peroxidase Regulates Plasmodium falciparum Development T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40754796; 4777691 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Kumar, Sanjeev AU - Gupta, Lalita AU - Barillas-Mury, Carolina Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Midgut KW - Peroxidase KW - Parasites KW - Aquatic insects KW - Anopheles KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=A+Secreted+Anopheles+Midgut+Peroxidase+Regulates+Plasmodium+falciparum+Development&rft.au=Kumar%2C+Sanjeev%3BGupta%2C+Lalita%3BBarillas-Mury%2C+Carolina&rft.aulast=Kumar&rft.aufirst=Sanjeev&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Animal Immunogenicity Studies of a Blood-Stage Malaria Vaccine Based on a Combination of AMA1 and MSP1@@d42@ T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40753612; 4776852 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Martin, Laura B AU - Long, Carole A AU - Zhou, Hong AU - Medina, Sarimar AU - Newland, Joseph AU - Moretz, Samuel E AU - Lambert, Lynn E AU - Mullen, Gregory E AU - Saul, Allan AU - Miller, Louis H Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Malaria KW - Immunogenicity KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40753612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Animal+Immunogenicity+Studies+of+a+Blood-Stage+Malaria+Vaccine+Based+on+a+Combination+of+AMA1+and+MSP1%40%40d42%40&rft.au=Martin%2C+Laura+B%3BLong%2C+Carole+A%3BZhou%2C+Hong%3BMedina%2C+Sarimar%3BNewland%2C+Joseph%3BMoretz%2C+Samuel+E%3BLambert%2C+Lynn+E%3BMullen%2C+Gregory+E%3BSaul%2C+Allan%3BMiller%2C+Louis+H&rft.aulast=Martin&rft.aufirst=Laura&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Towards a Vaccine Against Canine Visceral Leishmaniasis Based on Vector Salivary Antigens T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40751315; 4777728 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Collin, Nicolas AU - Kamhawi, Shaden AU - Gomes, Regis B AU - Teixeira, Clarissa AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Visceral leishmaniasis KW - Antigens KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40751315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Towards+a+Vaccine+Against+Canine+Visceral+Leishmaniasis+Based+on+Vector+Salivary+Antigens&rft.au=Collin%2C+Nicolas%3BKamhawi%2C+Shaden%3BGomes%2C+Regis+B%3BTeixeira%2C+Clarissa%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Collin&rft.aufirst=Nicolas&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Rapid and Specific Immunodiagnostic Assay for Strongyloides Infection using a Luciferase Immunoprecipitation System T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40750495; 4776937 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Ramanathan, Roshan AU - Burbelo, Peter B AU - Iadarola, Michael J AU - Neva, Franklin A AU - Nutman, Thomas B Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Immunoprecipitation KW - Strongyloides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40750495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Development+of+a+Rapid+and+Specific+Immunodiagnostic+Assay+for+Strongyloides+Infection+using+a+Luciferase+Immunoprecipitation+System&rft.au=Ramanathan%2C+Roshan%3BBurbelo%2C+Peter+B%3BIadarola%2C+Michael+J%3BNeva%2C+Franklin+A%3BNutman%2C+Thomas+B&rft.aulast=Ramanathan&rft.aufirst=Roshan&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Stat Pathway Limits Plasmodium Infection in An. gambiae T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749346; 4777037 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Barillas-Mury, Carolina AU - Gupta, Lalita AU - Molina-Cruz, Alvaro AU - Kumar, Sanjeev Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Infection KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=The+Stat+Pathway+Limits+Plasmodium+Infection+in+An.+gambiae&rft.au=Barillas-Mury%2C+Carolina%3BGupta%2C+Lalita%3BMolina-Cruz%2C+Alvaro%3BKumar%2C+Sanjeev&rft.aulast=Barillas-Mury&rft.aufirst=Carolina&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anopheles Gambiae Stat Pathway Participates in Mosquito Immunity T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749163; 4776846 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Gupta, Lalita AU - Kumar, Sanjeev Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Immunity KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Anopheles+Gambiae+Stat+Pathway+Participates+in+Mosquito+Immunity&rft.au=Gupta%2C+Lalita%3BKumar%2C+Sanjeev&rft.aulast=Gupta&rft.aufirst=Lalita&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Early Inflammatory Response Expression in Response to Phlebotomus duboscqi Bites T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40749038; 4776874 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Teixeira, Clarissa R AU - Kamhawi, Shaden AU - Gomes, Regis B AU - Oliveira, Luiz F AU - Elnaiem, Dia-eldin AU - Valenzuela, Jesus G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Bites KW - Inflammation KW - Phlebotomus duboscqi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40749038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Evaluation+of+Early+Inflammatory+Response+Expression+in+Response+to+Phlebotomus+duboscqi+Bites&rft.au=Teixeira%2C+Clarissa+R%3BKamhawi%2C+Shaden%3BGomes%2C+Regis+B%3BOliveira%2C+Luiz+F%3BElnaiem%2C+Dia-eldin%3BValenzuela%2C+Jesus+G&rft.aulast=Teixeira&rft.aufirst=Clarissa&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of Bloodstage Malaria Vaccines MSP1@@d42@-C1/Alhydrogel with and without the Addition of CPG 7909 in Us Adults T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748938; 4777007 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Martin, Laura B AU - Shaffer, Donna AU - Ellis, Ruth D AU - Long, Carole A AU - Miura, Kazutoyo AU - Narum, David L AU - Zhu, Daming AU - Mullen, Gregory E AU - Mahanty, Siddhartha AU - Malkin, Elissa AU - Miller, Louis H AU - Saul, Allan AU - Durbin, Anna P Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Vaccines KW - Malaria KW - Immunogenicity KW - CpG islands KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+Bloodstage+Malaria+Vaccines+MSP1%40%40d42%40-C1%2FAlhydrogel+with+and+without+the+Addition+of+CPG+7909+in+Us+Adults&rft.au=Martin%2C+Laura+B%3BShaffer%2C+Donna%3BEllis%2C+Ruth+D%3BLong%2C+Carole+A%3BMiura%2C+Kazutoyo%3BNarum%2C+David+L%3BZhu%2C+Daming%3BMullen%2C+Gregory+E%3BMahanty%2C+Siddhartha%3BMalkin%2C+Elissa%3BMiller%2C+Louis+H%3BSaul%2C+Allan%3BDurbin%2C+Anna+P&rft.aulast=Martin&rft.aufirst=Laura&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Antigenic Chimeric St. Louis Encephalitis Virus/Dengue Virus Type 4 Recombinant Viruses in Mice and Monkeys T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748414; 4776926 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Blaney, Joseph AU - Wlazlo, Anthony AU - Speicher, James AU - Sathe, Neeraj AU - Hanson, Christopher AU - Murphy, Brian AU - Whitehead, Stephen AU - Pletnev, Alexander Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Mice KW - Dengue KW - Viruses KW - Encephalitis KW - Recombinants KW - Dengue virus type 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Characterization+of+Antigenic+Chimeric+St.+Louis+Encephalitis+Virus%2FDengue+Virus+Type+4+Recombinant+Viruses+in+Mice+and+Monkeys&rft.au=Blaney%2C+Joseph%3BWlazlo%2C+Anthony%3BSpeicher%2C+James%3BSathe%2C+Neeraj%3BHanson%2C+Christopher%3BMurphy%2C+Brian%3BWhitehead%2C+Stephen%3BPletnev%2C+Alexander&rft.aulast=Blaney&rft.aufirst=Joseph&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Markers of the Pathogenesis of Cerebral Malaria in the Murine Malaria Plasmodium berghei T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40748178; 4776774 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Oakley, Miranda AU - Faucette, Laurence AU - Majam, Victoria AU - Zheng, Hong AU - Mahajan, Babita AU - Erexson, Cindy AU - Ward, Jerrold AU - McCutchan, Thomas AU - Kumar, Sanjai Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Malaria KW - Public health KW - Plasmodium berghei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40748178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Molecular+Markers+of+the+Pathogenesis+of+Cerebral+Malaria+in+the+Murine+Malaria+Plasmodium+berghei&rft.au=Oakley%2C+Miranda%3BFaucette%2C+Laurence%3BMajam%2C+Victoria%3BZheng%2C+Hong%3BMahajan%2C+Babita%3BErexson%2C+Cindy%3BWard%2C+Jerrold%3BMcCutchan%2C+Thomas%3BKumar%2C+Sanjai&rft.aulast=Oakley&rft.aufirst=Miranda&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Purified IgGs from Unvaccinated Malians Interfere with the Biological Activity of Apical Membrane Antigen 1-Specific IgGs as Judged by the in Vitro Growth Inhibition Assay T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40747354; 4776823 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Miura, Kazutoyo AU - Zhou, Hong AU - Mullen, Gregory AU - Moretz, Samuel AU - Diouf, Ababacar AU - Diemert, David AU - Dicko, Alassane AU - Miller, Louis AU - Doumbo, Ogobara AU - Long, Carole Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Membranes KW - Immunoglobulin G KW - Antigens KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40747354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Purified+IgGs+from+Unvaccinated+Malians+Interfere+with+the+Biological+Activity+of+Apical+Membrane+Antigen+1-Specific+IgGs+as+Judged+by+the+in+Vitro+Growth+Inhibition+Assay&rft.au=Miura%2C+Kazutoyo%3BZhou%2C+Hong%3BMullen%2C+Gregory%3BMoretz%2C+Samuel%3BDiouf%2C+Ababacar%3BDiemert%2C+David%3BDicko%2C+Alassane%3BMiller%2C+Louis%3BDoumbo%2C+Ogobara%3BLong%2C+Carole&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dichlorodiphenyltrichloroethane (DDT) for Indoor Residual Spraying in Africa: How can it be Used for Malaria Control? T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40746751; 4777018 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Tozan, Yesim AU - Sadasivaiah, Shobha AU - Breman, Joel G Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Africa KW - Malaria KW - Insecticides KW - DDT KW - Spraying KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40746751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Dichlorodiphenyltrichloroethane+%28DDT%29+for+Indoor+Residual+Spraying+in+Africa%3A+How+can+it+be+Used+for+Malaria+Control%3F&rft.au=Tozan%2C+Yesim%3BSadasivaiah%2C+Shobha%3BBreman%2C+Joel+G&rft.aulast=Tozan&rft.aufirst=Yesim&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Plasmodium falciparum in Culex Mosquitoes T2 - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AN - 40746089; 4777020 JF - 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene (ASTMH 2007) AU - Hume, Jen AU - Lehmann, Tovi Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Aquatic insects KW - Parasites KW - Plasmodium falciparum KW - Culex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40746089?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.atitle=Development+of+Plasmodium+falciparum+in+Culex+Mosquitoes&rft.au=Hume%2C+Jen%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=56th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene+%28ASTMH+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.astmh.org/meetings/07abstract/Final_program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Potential Interaction of Biglycan and WISP-1 in Controlling Differentiation and Proliferation of Osteogenic Cells T2 - 9th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT 9) AN - 40733184; 4770728 JF - 9th International Conference on the Chemistry and Biology of Mineralized Tissues (ICCBMT 9) AU - Inkson, Colette A AU - Bi, Yanming AU - Kuznetsov, Sergei A AU - Young, Marian F Y1 - 2007/11/04/ PY - 2007 DA - 2007 Nov 04 KW - Cell proliferation KW - Differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40733184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=9th+International+Conference+on+the+Chemistry+and+Biology+of+Mineralized+Tissues+%28ICCBMT+9%29&rft.atitle=The+Potential+Interaction+of+Biglycan+and+WISP-1+in+Controlling+Differentiation+and+Proliferation+of+Osteogenic+Cells&rft.au=Inkson%2C+Colette+A%3BBi%2C+Yanming%3BKuznetsov%2C+Sergei+A%3BYoung%2C+Marian+F&rft.aulast=Inkson&rft.aufirst=Colette&rft.date=2007-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=9th+International+Conference+on+the+Chemistry+and+Biology+of+Mineralized+Tissues+%28ICCBMT+9%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iccbmt.org/9th%20ICCBMT%20-%20Final%20Program%20for%20websi te.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Personality Disorder Severity and Mental Disability: Results from the National Epidemiologic Survey on Alcohol and Related Conditions T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40781104; 4784076 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Pulay, Attila J AU - Dawson, Deborah A AU - Ruan, W June AU - Pickering, Roger P AU - Huang, Boji AU - Chou, S Patricia AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Disabilities KW - Alcohols KW - Personality KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40781104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Personality+Disorder+Severity+and+Mental+Disability%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Pulay%2C+Attila+J%3BDawson%2C+Deborah+A%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BHuang%2C+Boji%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Pulay&rft.aufirst=Attila&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Supplements Labels Information for Consumers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40771653; 4781380 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Goshorn, Jeanne C AU - Chang, H Florence AU - Moore, Dorothy R AU - Sun, Ying AU - Hudson, Vera H AU - Hazard, George F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dietary supplements KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40771653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Dietary+Supplements+Labels+Information+for+Consumers&rft.au=Goshorn%2C+Jeanne+C%3BChang%2C+H+Florence%3BMoore%2C+Dorothy+R%3BSun%2C+Ying%3BHudson%2C+Vera+H%3BHazard%2C+George+F&rft.aulast=Goshorn&rft.aufirst=Jeanne&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Model for Policy Analysis and Science-Guided Advocacy for Community Health Improvement T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40770027; 4780354 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hammond, Camille AU - McLean, Barbara Gill AU - Cornelius, Llewellyn J AU - Baquet, Claudia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Models KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40770027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Model+for+Policy+Analysis+and+Science-Guided+Advocacy+for+Community+Health+Improvement&rft.au=Hammond%2C+Camille%3BMcLean%2C+Barbara+Gill%3BCornelius%2C+Llewellyn+J%3BBaquet%2C+Claudia&rft.aulast=Hammond&rft.aufirst=Camille&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Qualitative Evaluation of the Assessment of Cancer Screening and Follow-Up (ACIC-Ca) Tool: Findings from Cancer Collaborative Participants in the Pursuit of Quality Improvement T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769873; 4780308 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Ousley, Anita AU - Swarz, Jeff A AU - Bongiovanni, Annette AU - Sheahan, Daniel AU - Taplin, Stephen Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Qualitative+Evaluation+of+the+Assessment+of+Cancer+Screening+and+Follow-Up+%28ACIC-Ca%29+Tool%3A+Findings+from+Cancer+Collaborative+Participants+in+the+Pursuit+of+Quality+Improvement&rft.au=Ousley%2C+Anita%3BSwarz%2C+Jeff+A%3BBongiovanni%2C+Annette%3BSheahan%2C+Daniel%3BTaplin%2C+Stephen&rft.aulast=Ousley&rft.aufirst=Anita&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - New Disaster Information Management Research Center at the National Library of Medicine: Update for Public Health Workers T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40769851; 4780268 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Phillips, Steven J AU - Love, Cynthia B AU - Arnesen, Stacey J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40769851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=New+Disaster+Information+Management+Research+Center+at+the+National+Library+of+Medicine%3A+Update+for+Public+Health+Workers&rft.au=Phillips%2C+Steven+J%3BLove%2C+Cynthia+B%3BArnesen%2C+Stacey+J&rft.aulast=Phillips&rft.aufirst=Steven&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Systematic Approach for Evaluating Health Related Programs: Adaptation for Community-Based Participatory Research and Clinical Application to Reduce Cancer Health Disparities T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40768439; 4780259 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Taylor, Emmanuel A AU - Chu, Kenneth C AU - Newes-Adeyi, Gabriella M AU - Young, Paul A AU - Greene, Amanda Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Community involvement KW - Adaptations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40768439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Systematic+Approach+for+Evaluating+Health+Related+Programs%3A+Adaptation+for+Community-Based+Participatory+Research+and+Clinical+Application+to+Reduce+Cancer+Health+Disparities&rft.au=Taylor%2C+Emmanuel+A%3BChu%2C+Kenneth+C%3BNewes-Adeyi%2C+Gabriella+M%3BYoung%2C+Paul+A%3BGreene%2C+Amanda&rft.aulast=Taylor&rft.aufirst=Emmanuel&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integration of Criminal Justice and Substance Abuse Agencies: Measurement Concepts T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767975; 4780083 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fletcher, Bennett AU - Lehman, Wayne AU - Taxman, Faye S AU - Young, Douglas AU - Wexler, Harry AU - Melnik, Jerry Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Substance abuse KW - Integration KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Integration+of+Criminal+Justice+and+Substance+Abuse+Agencies%3A+Measurement+Concepts&rft.au=Fletcher%2C+Bennett%3BLehman%2C+Wayne%3BTaxman%2C+Faye+S%3BYoung%2C+Douglas%3BWexler%2C+Harry%3BMelnik%2C+Jerry&rft.aulast=Fletcher&rft.aufirst=Bennett&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Why aren't there More African-American Physicians? A Qualitative Study of African-American High-School Students' Perspectives T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767609; 4783302 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vijaya Rao, Glenn Flores Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Africa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Why+aren%27t+there+More+African-American+Physicians%3F+A+Qualitative+Study+of+African-American+High-School+Students%27+Perspectives&rft.au=Vijaya+Rao%2C+Glenn+Flores&rft.aulast=Vijaya+Rao&rft.aufirst=Glenn&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Federal and Community Partnership to Develop a Culturally Competent CVD Prevention Curriculum for Native Hawai'ian Youths T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767436; 4783260 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Woo, Violet Ryo-Hwa AU - Alvarado, Matilde Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Federal+and+Community+Partnership+to+Develop+a+Culturally+Competent+CVD+Prevention+Curriculum+for+Native+Hawai%27ian+Youths&rft.au=Woo%2C+Violet+Ryo-Hwa%3BAlvarado%2C+Matilde&rft.aulast=Woo&rft.aufirst=Violet&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Health Insurance Parity Laws on Healthcare Coverage for Alcohol-Related Hospitalizations in the United States T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767412; 4780189 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Yi, Hsiao-ye AU - Chen, Chiung M AU - Yoon, Young-Hee AU - Hilton, Michael E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Insurance KW - Health care KW - Parity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Effect+of+Health+Insurance+Parity+Laws+on+Healthcare+Coverage+for+Alcohol-Related+Hospitalizations+in+the+United+States&rft.au=Yi%2C+Hsiao-ye%3BChen%2C+Chiung+M%3BYoon%2C+Young-Hee%3BHilton%2C+Michael+E&rft.aulast=Yi&rft.aufirst=Hsiao-ye&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Resurrection of Extinct Pathogens: A Smart Move? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40767214; 4783398 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Fee, Elizabeth Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pathogens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40767214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Resurrection+of+Extinct+Pathogens%3A+A+Smart+Move%3F&rft.au=Fee%2C+Elizabeth&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Virtual Reality to Develop and Test Educational Approaches for Abstract Scientific Concepts. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766860; 4781943 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Kaphingst, Kimberly AU - Persky, Susan AU - Lachance, Christina AU - McCall, Cade AU - Driskell, Sara AU - Beall, Andrew AU - Blascovich, James Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Computer applications KW - Education KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Using+Virtual+Reality+to+Develop+and+Test+Educational+Approaches+for+Abstract+Scientific+Concepts.&rft.au=Kaphingst%2C+Kimberly%3BPersky%2C+Susan%3BLachance%2C+Christina%3BMcCall%2C+Cade%3BDriskell%2C+Sara%3BBeall%2C+Andrew%3BBlascovich%2C+James&rft.aulast=Kaphingst&rft.aufirst=Kimberly&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recruitment of Participants to a Familial Cancer Study: Balancing Privacy Protection and Research Quality T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766846; 4782510 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Slutsman, Julia AU - Wideroff, Louise AU - Willis, Gordon AU - Graubard, Barry AU - Dunn, Marcia AU - McNeel, Tim Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Recruitment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Recruitment+of+Participants+to+a+Familial+Cancer+Study%3A+Balancing+Privacy+Protection+and+Research+Quality&rft.au=Slutsman%2C+Julia%3BWideroff%2C+Louise%3BWillis%2C+Gordon%3BGraubard%2C+Barry%3BDunn%2C+Marcia%3BMcNeel%2C+Tim&rft.aulast=Slutsman&rft.aufirst=Julia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Patient Navigators Assist Minority Patients and Improve Quality of their Care and Health Outcomes T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766692; 4782347 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Colas, Maud AU - Freeman, Harold Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=How+Patient+Navigators+Assist+Minority+Patients+and+Improve+Quality+of+their+Care+and+Health+Outcomes&rft.au=Colas%2C+Maud%3BFreeman%2C+Harold&rft.aulast=Colas&rft.aufirst=Maud&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Typology of Violence Against Self and Others and its Associations with Drinking and Other Drug use among High School Students in a U.S. General Population Survey T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766649; 4780077 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Harford, Thomas C AU - Yi, Hsiao-ye AU - Freeman, Robert C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Violence KW - Drug abuse KW - Schools KW - Aggression KW - Typology KW - Drinking KW - Self KW - Population genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=A+Typology+of+Violence+Against+Self+and+Others+and+its+Associations+with+Drinking+and+Other+Drug+use+among+High+School+Students+in+a+U.S.+General+Population+Survey&rft.au=Harford%2C+Thomas+C%3BYi%2C+Hsiao-ye%3BFreeman%2C+Robert+C&rft.aulast=Harford&rft.aufirst=Thomas&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NCI Smoke-Free Meeting Policy T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40766283; 4780154 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - O'Connell, Mary Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Policies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40766283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=NCI+Smoke-Free+Meeting+Policy&rft.au=O%27Connell%2C+Mary&rft.aulast=O%27Connell&rft.aufirst=Mary&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institute on Alcohol Abuse and Alcoholism's Division of Epidemiology and Prevention Research Strategic Plan T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765656; 4780053 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hingson, Ralph W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Prevention KW - Alcohols KW - Drug abuse KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=National+Institute+on+Alcohol+Abuse+and+Alcoholism%27s+Division+of+Epidemiology+and+Prevention+Research+Strategic+Plan&rft.au=Hingson%2C+Ralph+W&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do Americans Age 50 and Older Discuss the use of Complementary and Alternative Medicine (CAM) with their Physicians? T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765438; 4782157 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Liu, Irene AU - Cotler, Alyssa AU - Law, Catherine AU - Thomsen, Chris AU - Hotra, Rives AU - Keenan, Teresa A AU - Brown, Helen W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Age KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Do+Americans+Age+50+and+Older+Discuss+the+use+of+Complementary+and+Alternative+Medicine+%28CAM%29+with+their+Physicians%3F&rft.au=Liu%2C+Irene%3BCotler%2C+Alyssa%3BLaw%2C+Catherine%3BThomsen%2C+Chris%3BHotra%2C+Rives%3BKeenan%2C+Teresa+A%3BBrown%2C+Helen+W&rft.aulast=Liu&rft.aufirst=Irene&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Being Proactive: Current Activities of the NIEHS Worker Education and Training Program and its Program Awardees in Preparing First Responders and Disaster Recovery Workers for Avian Influenza. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765433; 4782105 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Weinstock, Deborah L AU - Hughes, Joseph AU - Catlin, Mark D AU - Morawetz, John S AU - James, Xanthia Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Training KW - Disasters KW - Education KW - Influenza KW - Fowl plague KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Being+Proactive%3A+Current+Activities+of+the+NIEHS+Worker+Education+and+Training+Program+and+its+Program+Awardees+in+Preparing+First+Responders+and+Disaster+Recovery+Workers+for+Avian+Influenza.&rft.au=Weinstock%2C+Deborah+L%3BHughes%2C+Joseph%3BCatlin%2C+Mark+D%3BMorawetz%2C+John+S%3BJames%2C+Xanthia&rft.aulast=Weinstock&rft.aufirst=Deborah&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tailoring Evidence-Based Physical Activity Strategies in Minority Communities: One Size Does Not Fit All T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765347; 4784232 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Van Duyn, Mary Ann S. AU - McCrae, Tarsha AU - Wingrove, Barbara AU - Henderson, Kimberly M AU - Penalosa, Tricia L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Physical activity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Tailoring+Evidence-Based+Physical+Activity+Strategies+in+Minority+Communities%3A+One+Size+Does+Not+Fit+All&rft.au=Van+Duyn%2C+Mary+Ann+S.%3BMcCrae%2C+Tarsha%3BWingrove%2C+Barbara%3BHenderson%2C+Kimberly+M%3BPenalosa%2C+Tricia+L&rft.aulast=Van+Duyn&rft.aufirst=Mary+Ann&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Underage Hazardous Drinking and Failure to Graduate from High School: Results from the National Longitudinal Survey of Adolescent Health (Add Health) T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765248; 4780181 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Falk, Daniel E AU - Hingson, Ralph W AU - Shirley, Mariela C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Adolescents KW - Schools KW - Drinking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Underage+Hazardous+Drinking+and+Failure+to+Graduate+from+High+School%3A+Results+from+the+National+Longitudinal+Survey+of+Adolescent+Health+%28Add+Health%29&rft.au=Falk%2C+Daniel+E%3BHingson%2C+Ralph+W%3BShirley%2C+Mariela+C&rft.aulast=Falk&rft.aufirst=Daniel&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clean Air Policies Sweep the Nation Improving Public Health Every Step of the Way T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40765111; 4780152 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Vollinger, Bob Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40765111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Clean+Air+Policies+Sweep+the+Nation+Improving+Public+Health+Every+Step+of+the+Way&rft.au=Vollinger%2C+Bob&rft.aulast=Vollinger&rft.aufirst=Bob&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building Capacity in Formative Evaluation: The Role of CHWs T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764646; 4782250 DE: JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Wallace, Madeleine F AU - Rangel, Lourdes AU - Alvarado, Matilde AU - Ortiz, Gloria AU - Cate, Gladys Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Building+Capacity+in+Formative+Evaluation%3A+The+Role+of+CHWs&rft.au=Wallace%2C+Madeleine+F%3BRangel%2C+Lourdes%3BAlvarado%2C+Matilde%3BOrtiz%2C+Gloria%3BCate%2C+Gladys&rft.aulast=Wallace&rft.aufirst=Madeleine&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial and Ethnic Differences in Factors Affecting Treatment of Alcohol and Drug use Disorders T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764433; 4780065 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Smith, Sharon M AU - Goldstein, Rise B AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Alcohols KW - Drug abuse KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Racial+and+Ethnic+Differences+in+Factors+Affecting+Treatment+of+Alcohol+and+Drug+use+Disorders&rft.au=Smith%2C+Sharon+M%3BGoldstein%2C+Rise+B%3BGrant%2C+Bridget+F&rft.aulast=Smith&rft.aufirst=Sharon&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Importance of a Sound Evidence Base to Inform Food and Drug Administration Regulation of Tobacco Products: Input from the NIH T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40764410; 4779922 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Croyle, Robert T Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Tobacco KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40764410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Importance+of+a+Sound+Evidence+Base+to+Inform+Food+and+Drug+Administration+Regulation+of+Tobacco+Products%3A+Input+from+the+NIH&rft.au=Croyle%2C+Robert+T&rft.aulast=Croyle&rft.aufirst=Robert&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactive Effect between Paternal Smoking and CYP1A1 Haplotype on Childhood Leukemia Risk T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40763559; 4781134 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Lee, Kyoung-Mu AU - Ward, Mary H AU - Ahn, Hyo-Seop AU - Choi, Hyung-Soo AU - Shin, Hee-Young AU - Koo, Hong-Hoe AU - Seo, Jong-Jin AU - Choi, Ji-Eun AU - Han, Sohee AU - Ahn, Yoon-Ok AU - Kang, Daehee Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Haplotypes KW - Smoking KW - Leukemia KW - Children KW - Cytochrome P450 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40763559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Interactive+Effect+between+Paternal+Smoking+and+CYP1A1+Haplotype+on+Childhood+Leukemia+Risk&rft.au=Lee%2C+Kyoung-Mu%3BWard%2C+Mary+H%3BAhn%2C+Hyo-Seop%3BChoi%2C+Hyung-Soo%3BShin%2C+Hee-Young%3BKoo%2C+Hong-Hoe%3BSeo%2C+Jong-Jin%3BChoi%2C+Ji-Eun%3BHan%2C+Sohee%3BAhn%2C+Yoon-Ok%3BKang%2C+Daehee&rft.aulast=Lee&rft.aufirst=Kyoung-Mu&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Formative Research Findings from the National Cancer Institute on How to Design Web Sites to Meet the Cancer Information Needs of Latino Audiences T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762595; 4782569 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Salazar, Silvia Inez AU - Massett, Holly A AU - Manrow, Richard E AU - Killam, H William AU - Feldman, Sue K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cancer KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Formative+Research+Findings+from+the+National+Cancer+Institute+on+How+to+Design+Web+Sites+to+Meet+the+Cancer+Information+Needs+of+Latino+Audiences&rft.au=Salazar%2C+Silvia+Inez%3BMassett%2C+Holly+A%3BManrow%2C+Richard+E%3BKillam%2C+H+William%3BFeldman%2C+Sue+K&rft.aulast=Salazar&rft.aufirst=Silvia&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Racial/Ethnic Differences in Alcohol-Involvement among Drivers Fatally Injured in Traffic Crashes: United States, 2003-2004 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762535; 4779794 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Yi, Hsiao-Ye AU - Hingson, Ralph W AU - Arroyo, Judith A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Traffic safety KW - Accidents KW - Traffic KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Racial%2FEthnic+Differences+in+Alcohol-Involvement+among+Drivers+Fatally+Injured+in+Traffic+Crashes%3A+United+States%2C+2003-2004&rft.au=Yi%2C+Hsiao-Ye%3BHingson%2C+Ralph+W%3BArroyo%2C+Judith+A&rft.aulast=Yi&rft.aufirst=Hsiao-Ye&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State-Level Tobacco Policies and Youth Smoking Status T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40762105; 4784180 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Botello-Harbaum, Maria T AU - Murray, Kantahyanee AU - Haynie, Denise AU - Iannotti, Ronald AU - Gase, Lauren AU - Simons-Morton, Bruce G Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Smoking KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40762105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=State-Level+Tobacco+Policies+and+Youth+Smoking+Status&rft.au=Botello-Harbaum%2C+Maria+T%3BMurray%2C+Kantahyanee%3BHaynie%2C+Denise%3BIannotti%2C+Ronald%3BGase%2C+Lauren%3BSimons-Morton%2C+Bruce+G&rft.aulast=Botello-Harbaum&rft.aufirst=Maria&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ecological and Interventional Relationships between Polyunsaturated Fats, Major Depression and Aggression T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40761570; 4780633 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hibbeln, Joseph Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Aggressive behavior KW - Depression KW - Aggressive behaviour KW - Fats KW - Interspecific relationships KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40761570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Ecological+and+Interventional+Relationships+between+Polyunsaturated+Fats%2C+Major+Depression+and+Aggression&rft.au=Hibbeln%2C+Joseph&rft.aulast=Hibbeln&rft.aufirst=Joseph&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age Trends in Drinking Behaviors among Adolescents and Young Adults by Gender and Race/Ethnicity: National Survey on Drug use and Health (NSDUH), 1999-2005 T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760841; 4779875 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Williams, Gerald D AU - Chen, Chiung M AU - Yi, Hsiao-ye AU - Hilton, Michael E AU - Shirley, Mariela C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Adolescents KW - Ethnic groups KW - Drug abuse KW - Young adults KW - Age KW - Races KW - Drinking behavior KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Age+Trends+in+Drinking+Behaviors+among+Adolescents+and+Young+Adults+by+Gender+and+Race%2FEthnicity%3A+National+Survey+on+Drug+use+and+Health+%28NSDUH%29%2C+1999-2005&rft.au=Williams%2C+Gerald+D%3BChen%2C+Chiung+M%3BYi%2C+Hsiao-ye%3BHilton%2C+Michael+E%3BShirley%2C+Mariela+C&rft.aulast=Williams&rft.aufirst=Gerald&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - We Can! Helps Families and Communities Prevent Childhood Obesity. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760732; 4781856 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Donato, Karen AU - Miller, Marianne Glass Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Obesity KW - Children KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=We+Can%21+Helps+Families+and+Communities+Prevent+Childhood+Obesity.&rft.au=Donato%2C+Karen%3BMiller%2C+Marianne+Glass&rft.aulast=Donato&rft.aufirst=Karen&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender and Race-Ethnic Differentials in the Criterion Structure of Alcohol use Disorders T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760418; 4779795 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Saha, Tulshi D AU - Smith, Sharon AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sex KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Gender+and+Race-Ethnic+Differentials+in+the+Criterion+Structure+of+Alcohol+use+Disorders&rft.au=Saha%2C+Tulshi+D%3BSmith%2C+Sharon%3BGrant%2C+Bridget+F&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Alcohol use on School Performance of Us High School Students T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40760113; 4779894 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hingson, Ralph W AU - Zha, Wenxing Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Schools KW - Alcohols KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40760113?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Impact+of+Alcohol+use+on+School+Performance+of+Us+High+School+Students&rft.au=Hingson%2C+Ralph+W%3BZha%2C+Wenxing&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consulting with Television Writers to Encourage Cancer and Disparities Topics in Television Programs. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40758628; 4781870 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Miller, Michael AU - Berkowitz, Amanda AU - Beck, Vicki Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Television KW - Cancer KW - Television systems KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40758628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Consulting+with+Television+Writers+to+Encourage+Cancer+and+Disparities+Topics+in+Television+Programs.&rft.au=Miller%2C+Michael%3BBerkowitz%2C+Amanda%3BBeck%2C+Vicki&rft.aulast=Miller&rft.aufirst=Michael&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Safe Techniques Advance Research Science: An Innovative Method of Delivering Laboratory Safety Instruction to Students. T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40758444; 4781575 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Scanlon, Kelly A AU - Traum, Kerstin E AU - Krall, Suzanne E AU - Wilson, Deborah AU - Johnstone, Karyn Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Education KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40758444?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Safe+Techniques+Advance+Research+Science%3A+An+Innovative+Method+of+Delivering+Laboratory+Safety+Instruction+to+Students.&rft.au=Scanlon%2C+Kelly+A%3BTraum%2C+Kerstin+E%3BKrall%2C+Suzanne+E%3BWilson%2C+Deborah%3BJohnstone%2C+Karyn&rft.aulast=Scanlon&rft.aufirst=Kelly&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Contextual Factors Influence Disparities in Colorectal Cancer Screening T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40756596; 4781171 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Shariff-Marco, Salma N AU - Breen, Nancy AU - Klabunde, Carrie AU - Stinchcomb, David Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Colorectal cancer KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=How+Contextual+Factors+Influence+Disparities+in+Colorectal+Cancer+Screening&rft.au=Shariff-Marco%2C+Salma+N%3BBreen%2C+Nancy%3BKlabunde%2C+Carrie%3BStinchcomb%2C+David&rft.aulast=Shariff-Marco&rft.aufirst=Salma&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Chronic Dizziness or Imbalance on Falling and Performance on a Romberg Test of Standing Balance in U.S. Adults T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40756098; 4781298 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Hoffman, Howard J AU - Sklare, Daniel A AU - Chiu, May S AU - Losonczy, Katalin Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Disabilities KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40756098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Impact+of+Chronic+Dizziness+or+Imbalance+on+Falling+and+Performance+on+a+Romberg+Test+of+Standing+Balance+in+U.S.+Adults&rft.au=Hoffman%2C+Howard+J%3BSklare%2C+Daniel+A%3BChiu%2C+May+S%3BLosonczy%2C+Katalin&rft.aulast=Hoffman&rft.aufirst=Howard&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-Year Trajectory of Adult Antisocial Behavioral Syndromes in the General U.S. Population: Results from the National Epidemiologic Survey on Alcohol and Related Conditions T2 - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AN - 40754773; 4781186 JF - 135th Annual Meeting and Exposition of the American Public Health Association (APHA 2007) AU - Goldstein, Rise B AU - Grant, Bridget F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - USA KW - Alcohols KW - Social behavior KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40754773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.atitle=Three-Year+Trajectory+of+Adult+Antisocial+Behavioral+Syndromes+in+the+General+U.S.+Population%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Goldstein%2C+Rise+B%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=135th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association+%28APHA+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/135am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examining the Task-Specificity of Temporal Lobe Category Organization T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39715408; 4719010 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Simmons, W K AU - Matlis, S AU - Bellgowan, P S F AU - Bodurka, J AU - Barsalou, L W AU - Martin, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Temporal lobe KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39715408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Examining+the+Task-Specificity+of+Temporal+Lobe+Category+Organization&rft.au=Simmons%2C+W+K%3BMatlis%2C+S%3BBellgowan%2C+P+S+F%3BBodurka%2C+J%3BBarsalou%2C+L+W%3BMartin%2C+A&rft.aulast=Simmons&rft.aufirst=W&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Startle Reactivity in Children at Risk for Developing Migraine T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39714981; 4719540 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Duncko, R AU - Cui, L AU - Grillon, C AU - Merikangas, K R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Children KW - Risk assessment KW - Migraine KW - Headache KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39714981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Startle+Reactivity+in+Children+at+Risk+for+Developing+Migraine&rft.au=Duncko%2C+R%3BCui%2C+L%3BGrillon%2C+C%3BMerikangas%2C+K+R&rft.aulast=Duncko&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI Study of Response to Monetary Reward in Major Depressive Disorder T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39712359; 4717949 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Szczepanik, J E AU - Martin-Solech, C AU - Wang, H AU - Infante, A AU - Drevets, W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Economics KW - Reinforcement KW - Functional magnetic resonance imaging KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39712359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=fMRI+Study+of+Response+to+Monetary+Reward+in+Major+Depressive+Disorder&rft.au=Szczepanik%2C+J+E%3BMartin-Solech%2C+C%3BWang%2C+H%3BInfante%2C+A%3BDrevets%2C+W&rft.aulast=Szczepanik&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unraveling the Dopamine Receptor Signalplex: Reciprocal Modulation of Function between the D sub(1) and D sub(2) Dopamine Receptors and the Na super(+)/K super(+)-ATPase T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39698513; 4710956 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Hazelwood, L A AU - Free, R B AU - Cabrera, D M AU - Skinbjerg, M AU - Sibley, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39698513?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Unraveling+the+Dopamine+Receptor+Signalplex%3A+Reciprocal+Modulation+of+Function+between+the+D+sub%281%29+and+D+sub%282%29+Dopamine+Receptors+and+the+Na+super%28%2B%29%2FK+super%28%2B%29-ATPase&rft.au=Hazelwood%2C+L+A%3BFree%2C+R+B%3BCabrera%2C+D+M%3BSkinbjerg%2C+M%3BSibley%2C+D+R&rft.aulast=Hazelwood&rft.aufirst=L&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicity of the Expanded Polyglutamine Androgen Receptor is Reduced by AKT Phosphorylation at Serine 215 and 792 T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39697757; 4711638 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Pennuto, M AU - Palazzolo, I AU - Burnett, B AU - Howell, B AU - Fischbeck, K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Toxicity KW - Androgen receptors KW - Serine KW - Polyglutamine KW - AKT protein KW - Phosphorylation KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39697757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Toxicity+of+the+Expanded+Polyglutamine+Androgen+Receptor+is+Reduced+by+AKT+Phosphorylation+at+Serine+215+and+792&rft.au=Pennuto%2C+M%3BPalazzolo%2C+I%3BBurnett%2C+B%3BHowell%2C+B%3BFischbeck%2C+K&rft.aulast=Pennuto&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Muscarinic Cholinergic Receptors Modulate Attention and Emotional Stimulus Processing in Affective Disorders T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39695082; 4714142 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Furey, M L AU - Drevets, W C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Emotions KW - Affective disorders KW - Cholinergic receptors KW - Information processing KW - Acetylcholine receptors (muscarinic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39695082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Muscarinic+Cholinergic+Receptors+Modulate+Attention+and+Emotional+Stimulus+Processing+in+Affective+Disorders&rft.au=Furey%2C+M+L%3BDrevets%2C+W+C&rft.aulast=Furey&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Abnormal Hierarchical Topology of Structural Brain Networks as an Intermediate Phenotype for Schizophrenia T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39693358; 4708223 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bassett, D S AU - Bullmore, E AU - Verchinski, B AU - Duke, T AU - Mattay, V AU - Weinberger, D AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Schizophrenia KW - Mental disorders KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39693358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Abnormal+Hierarchical+Topology+of+Structural+Brain+Networks+as+an+Intermediate+Phenotype+for+Schizophrenia&rft.au=Bassett%2C+D+S%3BBullmore%2C+E%3BVerchinski%2C+B%3BDuke%2C+T%3BMattay%2C+V%3BWeinberger%2C+D%3BMeyer-Lindenberg%2C+A&rft.aulast=Bassett&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Reversible Inactivation of Pulvinar on Neural and BOLD Responses in Visual Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39689731; 4707055 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Wilke, M AU - Turchi, J AU - Zhu, C AU - Mueller, K M AU - Ye, F. AU - Leopold, D A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Inactivation KW - Pulvinar KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39689731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Reversible+Inactivation+of+Pulvinar+on+Neural+and+BOLD+Responses+in+Visual+Cortex&rft.au=Wilke%2C+M%3BTurchi%2C+J%3BZhu%2C+C%3BMueller%2C+K+M%3BYe%2C+F.%3BLeopold%2C+D+A&rft.aulast=Wilke&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mac-1 Mediates mpp super(+)-induced Reactive Microgliosis: Role in Neurodegeneration T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39656526; 4716952 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Hu, X. AU - Pang, H AU - Zhang, D AU - Liu, Y AU - Yang, S AU - Block, M AU - Wilson, B AU - Hong, J.-S. Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mac1 protein KW - Neurodegeneration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39656526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mac-1+Mediates+mpp+super%28%2B%29-induced+Reactive+Microgliosis%3A+Role+in+Neurodegeneration&rft.au=Hu%2C+X.%3BPang%2C+H%3BZhang%2C+D%3BLiu%2C+Y%3BYang%2C+S%3BBlock%2C+M%3BWilson%2C+B%3BHong%2C+J.-S.&rft.aulast=Hu&rft.aufirst=X.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Human Auditory Cortex Induced by Performing a Short-Term Memory (STM) Task: A Magnetoencephalographic (MEG) Study T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39651199; 4714419 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rong, F AU - Holroyd, T AU - Husain, F AU - Contreras-Vidal, J L AU - Horwtiz, B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Short term memory KW - Magnetoencephalography KW - Cortex (auditory) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39651199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+Human+Auditory+Cortex+Induced+by+Performing+a+Short-Term+Memory+%28STM%29+Task%3A+A+Magnetoencephalographic+%28MEG%29+Study&rft.au=Rong%2C+F%3BHolroyd%2C+T%3BHusain%2C+F%3BContreras-Vidal%2C+J+L%3BHorwtiz%2C+B&rft.aulast=Rong&rft.aufirst=F&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral Characterization of Dentate Mossy Cell-restricted NMDA Receptor Knockout Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39632067; 4716542 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Jinde, S AU - Cravens, C J AU - Nakazawa, K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39632067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+Characterization+of+Dentate+Mossy+Cell-restricted+NMDA+Receptor+Knockout+Mice&rft.au=Jinde%2C+S%3BCravens%2C+C+J%3BNakazawa%2C+K&rft.aulast=Jinde&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity-dependent Transcription of BDNF through Promoter 3 Contributes to Function in Prefrontal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39631732; 4716510 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Sakata, K AU - Lu, B. Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Promoters KW - Transcription KW - Brain-derived neurotrophic factor KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39631732?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity-dependent+Transcription+of+BDNF+through+Promoter+3+Contributes+to+Function+in+Prefrontal+Cortex&rft.au=Sakata%2C+K%3BLu%2C+B.&rft.aulast=Sakata&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PAS-Induced Changes in Spinal Excitability T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39629136; 4710404 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Lamy, J.-C. D. AU - Russmann, H AU - Meunier, S O AU - Hallett, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Excitability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39629136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PAS-Induced+Changes+in+Spinal+Excitability&rft.au=Lamy%2C+J.-C.+D.%3BRussmann%2C+H%3BMeunier%2C+S+O%3BHallett%2C+M&rft.aulast=Lamy&rft.aufirst=J.-C.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sub-Anesthetic Doses of Propofol Induce Neuroapoptosis in the Infant Mouse Brain T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39628471; 4713777 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Cattano, D AU - Young, C AU - Olney, J W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Infants KW - Propofol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39628471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sub-Anesthetic+Doses+of+Propofol+Induce+Neuroapoptosis+in+the+Infant+Mouse+Brain&rft.au=Cattano%2C+D%3BYoung%2C+C%3BOlney%2C+J+W&rft.aulast=Cattano&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intersubject Variability in Expectation Modulation of Fearful Face Discrimination T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39627936; 4708682 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Doty, T J AU - Ingvar, M AU - Ungerleider, L G Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39627936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Intersubject+Variability+in+Expectation+Modulation+of+Fearful+Face+Discrimination&rft.au=Doty%2C+T+J%3BIngvar%2C+M%3BUngerleider%2C+L+G&rft.aulast=Doty&rft.aufirst=T&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Anxiety by Tuberoinfundibular Peptide of 39 Residues T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39625384; 4712911 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Weiss, J R AU - Fegley, D B AU - Holmes, A AU - Riordan, T AU - Faber, C A AU - Ma, S. AU - Sleeman, M AU - Usdin, T B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Residues KW - Anxiety KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39625384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+Anxiety+by+Tuberoinfundibular+Peptide+of+39+Residues&rft.au=Weiss%2C+J+R%3BFegley%2C+D+B%3BHolmes%2C+A%3BRiordan%2C+T%3BFaber%2C+C+A%3BMa%2C+S.%3BSleeman%2C+M%3BUsdin%2C+T+B&rft.aulast=Weiss&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Dopamine Receptor Antagonists on Laryngeal Sensorimotor Reflex in Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39622106; 4713150 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Feng, X AU - Henriquez, V M AU - Walters, J R AU - Ludlow, C L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Dopamine receptors KW - Sensorimotor system KW - Reflexes KW - Antagonists KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39622106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Dopamine+Receptor+Antagonists+on+Laryngeal+Sensorimotor+Reflex+in+Rats&rft.au=Feng%2C+X%3BHenriquez%2C+V+M%3BWalters%2C+J+R%3BLudlow%2C+C+L&rft.aulast=Feng&rft.aufirst=X&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Phosphorylation in D sub(2) Dopamine Receptor Regulation T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39621315; 4710959 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Namkung, Y AU - Sibley, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Phosphorylation KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39621315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Role+of+Phosphorylation+in+D+sub%282%29+Dopamine+Receptor+Regulation&rft.au=Namkung%2C+Y%3BSibley%2C+D+R&rft.aulast=Namkung&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sound Level Dependent Activation in the Macaque Auditory Cortex - An fMRI Study T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39616853; 4716012 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tanji, K AU - Leopold, D AU - Ye, F. AU - Zhu, C AU - Malloy, M AU - Saunders, R AU - Mishkin, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Functional magnetic resonance imaging KW - Cortex (auditory) KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39616853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sound+Level+Dependent+Activation+in+the+Macaque+Auditory+Cortex+-+An+fMRI+Study&rft.au=Tanji%2C+K%3BLeopold%2C+D%3BYe%2C+F.%3BZhu%2C+C%3BMalloy%2C+M%3BSaunders%2C+R%3BMishkin%2C+M&rft.aulast=Tanji&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Positive Shift in the Reversal Potential for GABA Underlies Compensatory Synaptic Changes in GABAergic mPSCs Amplitude Following Reduced Activity in the Chick Embryo T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39616401; 4718689 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Chub, N AU - Gonzalez-Islas, C AU - Wenner, P Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Embryos KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39616401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Positive+Shift+in+the+Reversal+Potential+for+GABA+Underlies+Compensatory+Synaptic+Changes+in+GABAergic+mPSCs+Amplitude+Following+Reduced+Activity+in+the+Chick+Embryo&rft.au=Chub%2C+N%3BGonzalez-Islas%2C+C%3BWenner%2C+P&rft.aulast=Chub&rft.aufirst=N&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Architecture of the Postsynaptic Density in Cultured Hippocampal Neurons T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39615903; 4718571 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Chen, X AU - Winters, C AU - Azzam, R AU - Li, X. AU - Galbraith, J AU - Leapman, R D AU - Reese, T S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hippocampus KW - Postsynaptic density KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Architecture+of+the+Postsynaptic+Density+in+Cultured+Hippocampal+Neurons&rft.au=Chen%2C+X%3BWinters%2C+C%3BAzzam%2C+R%3BLi%2C+X.%3BGalbraith%2C+J%3BLeapman%2C+R+D%3BReese%2C+T+S&rft.aulast=Chen&rft.aufirst=X&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotrophins Co-Operate with Integrin b1 and L-Type Calcium Channels to Promote Survival of Hippocampal Neurons during Developmental Cell Death T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39615346; 4717330 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Murase, S AU - Owens, D AU - Poser, S W AU - Mckay, R D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Channels KW - Mortality KW - Survival KW - Calcium channels (L-type) KW - Cell survival KW - Cell death KW - Hippocampus KW - Integrins KW - Neurotrophins KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39615346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurotrophins+Co-Operate+with+Integrin+b1+and+L-Type+Calcium+Channels+to+Promote+Survival+of+Hippocampal+Neurons+during+Developmental+Cell+Death&rft.au=Murase%2C+S%3BOwens%2C+D%3BPoser%2C+S+W%3BMckay%2C+R+D&rft.aulast=Murase&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered RNA Editing of the Serotonin 2C Receptor (Htr2c) Receptor in the Amygdala of Mice with Targeted Deletion of the Serotonin Transporter T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39612665; 4706255 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Moya, P R AU - Jensen, C AU - Wendland, J R AU - Fox, M A AU - Murphy, D L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Serotonin transporter KW - Gene deletion KW - Amygdala KW - RNA editing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+RNA+Editing+of+the+Serotonin+2C+Receptor+%28Htr2c%29+Receptor+in+the+Amygdala+of+Mice+with+Targeted+Deletion+of+the+Serotonin+Transporter&rft.au=Moya%2C+P+R%3BJensen%2C+C%3BWendland%2C+J+R%3BFox%2C+M+A%3BMurphy%2C+D+L&rft.aulast=Moya&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of AMPA Receptor Subunit GluR1 in the Affective-like Behavior and the Behavioral Effects of Mood Stabilizers and Antidepressants T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39612347; 4706200 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Malkesman, O AU - Gould, T D AU - Creson, T AU - Du, J. AU - Chen, G AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Antidepressants KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Mood KW - Glutamic acid receptors (ionotropic) KW - Stabilizers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39612347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Role+of+AMPA+Receptor+Subunit+GluR1+in+the+Affective-like+Behavior+and+the+Behavioral+Effects+of+Mood+Stabilizers+and+Antidepressants&rft.au=Malkesman%2C+O%3BGould%2C+T+D%3BCreson%2C+T%3BDu%2C+J.%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Malkesman&rft.aufirst=O&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptic Adhesion-Like Molecules (SALMs) Promote Neurite Outgrowth T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39609219; 4709552 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Wang, P Y AU - Seabold, G K AU - Wang, Y.-X. AU - Chang, K AU - Wenthold, R J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Axonogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39609219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synaptic+Adhesion-Like+Molecules+%28SALMs%29+Promote+Neurite+Outgrowth&rft.au=Wang%2C+P+Y%3BSeabold%2C+G+K%3BWang%2C+Y.-X.%3BChang%2C+K%3BWenthold%2C+R+J&rft.aulast=Wang&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 10 Things I Hate About You: The Neural Response to Self-referential Statements in Generalized Social Phobia (GSP) T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39608209; 4720357 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Peschardt, K AU - Geraci, M AU - Devido, J AU - Mccaffrey, D AU - Blair, J AU - Pine, D S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Anxiety KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39608209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=10+Things+I+Hate+About+You%3A+The+Neural+Response+to+Self-referential+Statements+in+Generalized+Social+Phobia+%28GSP%29&rft.au=Peschardt%2C+K%3BGeraci%2C+M%3BDevido%2C+J%3BMccaffrey%2C+D%3BBlair%2C+J%3BPine%2C+D+S&rft.aulast=Peschardt&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Acute Alcohol Administration on Processing of Emotionally Affective Stimuli in Social Drinkers T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39608173; 4720356 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gilman, J M AU - Ramchandani, V A AU - Davis, M B AU - Hommer, D W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Alcohols KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39608173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Acute+Alcohol+Administration+on+Processing+of+Emotionally+Affective+Stimuli+in+Social+Drinkers&rft.au=Gilman%2C+J+M%3BRamchandani%2C+V+A%3BDavis%2C+M+B%3BHommer%2C+D+W&rft.aulast=Gilman&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Supercritical Working Brain T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39608056; 4716498 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Petermann, T AU - Priesemann, V AU - Munk, M H J AU - Plenz, D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39608056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Supercritical+Working+Brain&rft.au=Petermann%2C+T%3BPriesemann%2C+V%3BMunk%2C+M+H+J%3BPlenz%2C+D&rft.aulast=Petermann&rft.aufirst=T&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allelic Variation in NOS1AP (CAPON) is Associated with Altered Prefrontal Cortex Function T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39605047; 4713779 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Callicott, J H AU - Nicodemus, K K AU - Higier, R G AU - Tan, H Y AU - Buckholtz, J W AU - Kolachana, B AU - Straub, R E AU - Weinberger, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39605047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Allelic+Variation+in+NOS1AP+%28CAPON%29+is+Associated+with+Altered+Prefrontal+Cortex+Function&rft.au=Callicott%2C+J+H%3BNicodemus%2C+K+K%3BHigier%2C+R+G%3BTan%2C+H+Y%3BBuckholtz%2C+J+W%3BKolachana%2C+B%3BStraub%2C+R+E%3BWeinberger%2C+D+R&rft.aulast=Callicott&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Examining Dopaminergic Axon Growth, Guidance and Synaptogenesis in Development and Regeneration T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39604901; 4715527 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Mendes, S W AU - Lin, L AU - Isacson, O Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Regeneration KW - Axon guidance KW - Axonogenesis KW - Synaptogenesis KW - Dopamine KW - Growth KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39604901?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Examining+Dopaminergic+Axon+Growth%2C+Guidance+and+Synaptogenesis+in+Development+and+Regeneration&rft.au=Mendes%2C+S+W%3BLin%2C+L%3BIsacson%2C+O&rft.aulast=Mendes&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a PKA Phosphorylation Site on the Kainate Receptor GluR6 that Regulates Receptor Surface Expression T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39602982; 4707733 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Nishimura, Y AU - Kelver, D AU - Isaac, J T R AU - Roche, K W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Protein kinase A KW - Glutamic acid receptors KW - Kainic acid receptors KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39602982?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+PKA+Phosphorylation+Site+on+the+Kainate+Receptor+GluR6+that+Regulates+Receptor+Surface+Expression&rft.au=Nishimura%2C+Y%3BKelver%2C+D%3BIsaac%2C+J+T+R%3BRoche%2C+K+W&rft.aulast=Nishimura&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Intrinsic Excitability and Synaptic Strength in Striatal Subregions Accompanying Fast and Slow Skill Learning T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39601466; 4720130 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Yin, H H AU - Prasad-Mulcare, S AU - Clouse, E AU - Lovinger, D M AU - Costa, R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - Synaptic strength KW - Neostriatum KW - Excitability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Changes+in+Intrinsic+Excitability+and+Synaptic+Strength+in+Striatal+Subregions+Accompanying+Fast+and+Slow+Skill+Learning&rft.au=Yin%2C+H+H%3BPrasad-Mulcare%2C+S%3BClouse%2C+E%3BLovinger%2C+D+M%3BCosta%2C+R&rft.aulast=Yin&rft.aufirst=H&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Matching Categorical Object Representations in Inferotemporal Cortex of Man and Monkey T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39601276; 4714374 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Kriegeskorte, N AU - Mur, M AU - Ruff, D AU - Kiani, R AU - Bodurka, J AU - Bandettini, P Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (inferotemporal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39601276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Matching+Categorical+Object+Representations+in+Inferotemporal+Cortex+of+Man+and+Monkey&rft.au=Kriegeskorte%2C+N%3BMur%2C+M%3BRuff%2C+D%3BKiani%2C+R%3BBodurka%2C+J%3BBandettini%2C+P&rft.aulast=Kriegeskorte&rft.aufirst=N&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Detection of Changes in Gene Expression in the Brain of Awake Behaving Mice using Fiber Optics T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39600405; 4711312 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Cui, G AU - Pham, M D AU - Thaler, C AU - Vogel, S S AU - Costa, R M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Fibers KW - Brain KW - Optics KW - Gene expression KW - Fiber optics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39600405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Vivo+Detection+of+Changes+in+Gene+Expression+in+the+Brain+of+Awake+Behaving+Mice+using+Fiber+Optics&rft.au=Cui%2C+G%3BPham%2C+M+D%3BThaler%2C+C%3BVogel%2C+S+S%3BCosta%2C+R+M&rft.aulast=Cui&rft.aufirst=G&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Left Anterior Temporal Lobectomy Eliminates Repetition Priming and Repetition Suppression in Posterior Occipitotemporal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39600206; 4718295 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ritzl, E AU - Bellgowan, P S F AU - Dolan, L A AU - Theodore, W H AU - Martin, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Repetition KW - Cortex (temporal) KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39600206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Left+Anterior+Temporal+Lobectomy+Eliminates+Repetition+Priming+and+Repetition+Suppression+in+Posterior+Occipitotemporal+Cortex&rft.au=Ritzl%2C+E%3BBellgowan%2C+P+S+F%3BDolan%2C+L+A%3BTheodore%2C+W+H%3BMartin%2C+A&rft.aulast=Ritzl&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lesions of Orbitofrontal Cortex in Rhesus Monkeys Disrupt Assessments of Outcome Value as a Function of Cost T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39598497; 4717944 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Simmons, J M AU - Minamimoto, T AU - Murray, E A AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Lesions KW - Cortex KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lesions+of+Orbitofrontal+Cortex+in+Rhesus+Monkeys+Disrupt+Assessments+of+Outcome+Value+as+a+Function+of+Cost&rft.au=Simmons%2C+J+M%3BMinamimoto%2C+T%3BMurray%2C+E+A%3BRichmond%2C+B+J&rft.aulast=Simmons&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Locus Coeruleus Activity: Relation to Instinctive and Operant Behavior T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39598450; 4717943 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bouret, S AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Locus coeruleus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Locus+Coeruleus+Activity%3A+Relation+to+Instinctive+and+Operant+Behavior&rft.au=Bouret%2C+S%3BRichmond%2C+B+J&rft.aulast=Bouret&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Neuroplasticity in the Basolateral Nucleus of the Amygdala of Kindled Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39598133; 4718316 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Fritsch, B AU - Stott, J J AU - Reis, J AU - Braga, M F Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Plasticity KW - Amygdala KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39598133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+Neuroplasticity+in+the+Basolateral+Nucleus+of+the+Amygdala+of+Kindled+Rats&rft.au=Fritsch%2C+B%3BStott%2C+J+J%3BReis%2C+J%3BBraga%2C+M+F&rft.aulast=Fritsch&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Redefining Neural Stem Cells: Reaching for a Consensus T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39597937; 4717213 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y H AU - Barker, J L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Stem cells KW - Neural stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39597937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Redefining+Neural+Stem+Cells%3A+Reaching+for+a+Consensus&rft.au=Maric%2C+D%3BChang%2C+Y+H%3BBarker%2C+J+L&rft.aulast=Maric&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Many Faces of NF-kB1 (p50): Modulation of Brain Pro-Inflammatory Cytokine Response and Spatial Learning through Chromatin Remodeling T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39597812; 4716602 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Lehmann, M L AU - Herkenham, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Chromatin remodeling KW - Spatial memory KW - Cytokines KW - NF-B protein KW - Spatial discrimination learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39597812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Many+Faces+of+NF-kB1+%28p50%29%3A+Modulation+of+Brain+Pro-Inflammatory+Cytokine+Response+and+Spatial+Learning+through+Chromatin+Remodeling&rft.au=Lehmann%2C+M+L%3BHerkenham%2C+M&rft.aulast=Lehmann&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of the Cannabinoid Receptor CNR1 in Schizophrenia and Across Life Span in Postmortem Human Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39594350; 4709818 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Kleinman, J E AU - Joseph, A AU - Joseph, L AU - Hyde, T M AU - Mitkus, S AU - Ye, T. AU - Herman, M M AU - Kolachana, B AU - Lipska, B K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Life span KW - Schizophrenia KW - Mental disorders KW - Cortex KW - Cannabinoid receptors KW - Longevity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39594350?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+of+the+Cannabinoid+Receptor+CNR1+in+Schizophrenia+and+Across+Life+Span+in+Postmortem+Human+Cortex&rft.au=Kleinman%2C+J+E%3BJoseph%2C+A%3BJoseph%2C+L%3BHyde%2C+T+M%3BMitkus%2C+S%3BYe%2C+T.%3BHerman%2C+M+M%3BKolachana%2C+B%3BLipska%2C+B+K&rft.aulast=Kleinman&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostaglandin E sub(2)-mediated Microglia/Astrocyte Interaction and Enhances Astrogliosis T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39593884; 4716954 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zhang, D AU - Wang, T AU - Pei, Z AU - Zhang, W AU - Liu, B AU - Wilson, B AU - Miller, D S AU - Hong, J.-S. Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Microglia KW - Gliosis KW - Astrocytes KW - Prostaglandins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Prostaglandin+E+sub%282%29-mediated+Microglia%2FAstrocyte+Interaction+and+Enhances+Astrogliosis&rft.au=Zhang%2C+D%3BWang%2C+T%3BPei%2C+Z%3BZhang%2C+W%3BLiu%2C+B%3BWilson%2C+B%3BMiller%2C+D+S%3BHong%2C+J.-S.&rft.aulast=Zhang&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differences in Late Developmental Changes between Thalamic and Cortical Inputs to Lateral Amygdala T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39593194; 4712179 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Pan, B AU - Ito, W AU - Morozov, A Y Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Amygdala KW - Cortex KW - Developmental stages KW - Thalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39593194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differences+in+Late+Developmental+Changes+between+Thalamic+and+Cortical+Inputs+to+Lateral+Amygdala&rft.au=Pan%2C+B%3BIto%2C+W%3BMorozov%2C+A+Y&rft.aulast=Pan&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Recent and Remote Contextual Fear Memory using fMRI T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39589247; 4715067 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Alvarez, R P AU - Biggs, A AU - Grillon, C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Fear KW - Functional magnetic resonance imaging KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39589247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Comparison+of+Recent+and+Remote+Contextual+Fear+Memory+using+fMRI&rft.au=Alvarez%2C+R+P%3BBiggs%2C+A%3BGrillon%2C+C&rft.aulast=Alvarez&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The A-Type K+ Channel Subunit Kv4.2 Regulates Synaptic NMDAR Subunit Composition through an Active CaMKII-Dependent Mechanism T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39587914; 4718095 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Jung, S AU - Kim, J AU - Hoffman, D A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Potassium channels KW - Glutamic acid receptors KW - Subunit structure KW - Potassium channels (voltage-gated) KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39587914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+A-Type+K%2B+Channel+Subunit+Kv4.2+Regulates+Synaptic+NMDAR+Subunit+Composition+through+an+Active+CaMKII-Dependent+Mechanism&rft.au=Jung%2C+S%3BKim%2C+J%3BHoffman%2C+D+A&rft.aulast=Jung&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Early Life Stress on 5-HT sub(1A) Receptor Availability in Two Years Old Rhesus Monkeys Measured by [ super(18)F]-FPWAY and PET T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39586648; 4718467 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Spinelli, S AU - Carson, R E AU - Barr, C S AU - Heilig, M AU - Suomi, S AU - Higley, J D AU - Lang, L AU - Stein, E AU - Chefer, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Stress KW - Serotonin S1 receptors KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39586648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Early+Life+Stress+on+5-HT+sub%281A%29+Receptor+Availability+in+Two+Years+Old+Rhesus+Monkeys+Measured+by+%5B+super%2818%29F%5D-FPWAY+and+PET&rft.au=Spinelli%2C+S%3BCarson%2C+R+E%3BBarr%2C+C+S%3BHeilig%2C+M%3BSuomi%2C+S%3BHigley%2C+J+D%3BLang%2C+L%3BStein%2C+E%3BChefer%2C+S&rft.aulast=Spinelli&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Segmenting Thalamic Nuclei using Probabilistic Diffusion Tensor Imaging and Functional Connectivity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39586365; 4714223 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Stein, J L AU - Savostyanova, A A AU - Goldman, A L AU - Reed, J D AU - Zink, C F AU - Weinberger, D R AU - Mattay, V S AU - Marenco, S AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Diffusion KW - Magnetic resonance imaging KW - Thalamic nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39586365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Segmenting+Thalamic+Nuclei+using+Probabilistic+Diffusion+Tensor+Imaging+and+Functional+Connectivity&rft.au=Stein%2C+J+L%3BSavostyanova%2C+A+A%3BGoldman%2C+A+L%3BReed%2C+J+D%3BZink%2C+C+F%3BWeinberger%2C+D+R%3BMattay%2C+V+S%3BMarenco%2C+S%3BMeyer-Lindenberg%2C+A&rft.aulast=Stein&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI Investigation of the Impact of Genetic Variance in Pten on the Neural Correlates of Face Emotion Processing T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39584758; 4719053 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Hakimi, S AU - Kempf, L P AU - Kolachana, B AU - Verchinski, B A AU - Tong, Y AU - Mattay, V S AU - Weinberger, D R AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Genetic variance KW - Pattern recognition KW - Face KW - PTEN protein KW - Emotions KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=fMRI+Investigation+of+the+Impact+of+Genetic+Variance+in+Pten+on+the+Neural+Correlates+of+Face+Emotion+Processing&rft.au=Hakimi%2C+S%3BKempf%2C+L+P%3BKolachana%2C+B%3BVerchinski%2C+B+A%3BTong%2C+Y%3BMattay%2C+V+S%3BWeinberger%2C+D+R%3BMeyer-Lindenberg%2C+A&rft.aulast=Hakimi&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carboxypeptidase E is Required for Hippocampal Formation, Memory and Learning T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39584133; 4720067 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Woronowicz, A AU - Chang, S.-Y. AU - Cawley, N X AU - Hill, J M AU - Rodriguiz, R M AU - Abebe, D AU - Dorfman, C AU - Zhou, A AU - Xiong, Z.-G. AU - Wetsel, W C AU - Loh, Y Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - Carboxypeptidase E KW - Hippocampus KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Carboxypeptidase+E+is+Required+for+Hippocampal+Formation%2C+Memory+and+Learning&rft.au=Woronowicz%2C+A%3BChang%2C+S.-Y.%3BCawley%2C+N+X%3BHill%2C+J+M%3BRodriguiz%2C+R+M%3BAbebe%2C+D%3BDorfman%2C+C%3BZhou%2C+A%3BXiong%2C+Z.-G.%3BWetsel%2C+W+C%3BLoh%2C+Y&rft.aulast=Woronowicz&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinguishing Intention and Attention Signals in Primate Frontal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39584020; 4720045 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Messinger, A C AU - Wise, S P Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Primates KW - Cortex (frontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39584020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Distinguishing+Intention+and+Attention+Signals+in+Primate+Frontal+Cortex&rft.au=Messinger%2C+A+C%3BWise%2C+S+P&rft.aulast=Messinger&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Activity in the Primate Lateral Habenula during Appetitive and Aversive Classical Conditioning T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39583156; 4719264 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Matsumoto, M AU - Hikosaka, O Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Primates KW - Classical conditioning KW - Habenula KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39583156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Activity+in+the+Primate+Lateral+Habenula+during+Appetitive+and+Aversive+Classical+Conditioning&rft.au=Matsumoto%2C+M%3BHikosaka%2C+O&rft.aulast=Matsumoto&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Alcohol Alters BKca Potassium Channel Activity through Protein Phosphatase 1 T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39582940; 4713458 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ma, L. AU - Zhang, X AU - Scappini, E AU - Wu, S. AU - Erxleben, C AU - Armstrong, D L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Potassium channels KW - Alcohols KW - Phosphoprotein phosphatase KW - Phosphatase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Alcohol+Alters+BKca+Potassium+Channel+Activity+through+Protein+Phosphatase+1&rft.au=Ma%2C+L.%3BZhang%2C+X%3BScappini%2C+E%3BWu%2C+S.%3BErxleben%2C+C%3BArmstrong%2C+D+L&rft.aulast=Ma&rft.aufirst=L.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Learning from Mistakes: Separating Cue and Reinforcement-based Responding in a Reversal Learning Task T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39582848; 4711369 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ng, P. AU - Peschardt, K AU - Crowe, S AU - Marsh, A AU - Finger, E AU - Blair, R J R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - Reversal learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39582848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Learning+from+Mistakes%3A+Separating+Cue+and+Reinforcement-based+Responding+in+a+Reversal+Learning+Task&rft.au=Ng%2C+P.%3BPeschardt%2C+K%3BCrowe%2C+S%3BMarsh%2C+A%3BFinger%2C+E%3BBlair%2C+R+J+R&rft.aulast=Ng&rft.aufirst=P.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Encoding of Temporal Discounting of Predicted Reward in the Primate Caudate Nucleus T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39581560; 4717941 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Minamimoto, T AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Primates KW - Reinforcement KW - Caudate nucleus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Encoding+of+Temporal+Discounting+of+Predicted+Reward+in+the+Primate+Caudate+Nucleus&rft.au=Minamimoto%2C+T%3BRichmond%2C+B+J&rft.aulast=Minamimoto&rft.aufirst=T&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Changes in Histone Methylation of BDNF Gene Promoters Following NMDA Receptor Activation in Hippocampal Neurons T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39581507; 4712043 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tian, F AU - Hu, X. AU - Lipsky, R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - Histones KW - Hippocampus KW - Promoters KW - Neurons KW - Methylation KW - Receptor mechanisms KW - Brain-derived neurotrophic factor KW - DNA methylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Changes+in+Histone+Methylation+of+BDNF+Gene+Promoters+Following+NMDA+Receptor+Activation+in+Hippocampal+Neurons&rft.au=Tian%2C+F%3BHu%2C+X.%3BLipsky%2C+R&rft.aulast=Tian&rft.aufirst=F&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Fear by Tuberoinfundibular Peptide of 39 Residues T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39581389; 4712907 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Fegley, D B AU - Holmes, A AU - Riordan, T AU - Faber, C AU - Weiss, J R AU - Ma, S. AU - Sleeman, M AU - Usdin, T B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Residues KW - Fear KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+Fear+by+Tuberoinfundibular+Peptide+of+39+Residues&rft.au=Fegley%2C+D+B%3BHolmes%2C+A%3BRiordan%2C+T%3BFaber%2C+C%3BWeiss%2C+J+R%3BMa%2C+S.%3BSleeman%2C+M%3BUsdin%2C+T+B&rft.aulast=Fegley&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential Failure due to an Activity-Dependent Change in the Depolarization Required to Reach Threshold T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39581154; 4718692 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Paradiso, K G AU - Wu, L.-G. Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Action potential KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39581154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Action+Potential+Failure+due+to+an+Activity-Dependent+Change+in+the+Depolarization+Required+to+Reach+Threshold&rft.au=Paradiso%2C+K+G%3BWu%2C+L.-G.&rft.aulast=Paradiso&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Depolarization and NMDA Induce Spinule Formation at Hippocampal CA1 Synapses T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39580657; 4712201 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tao-Cheng, J.-H. AU - Dosemeci, A AU - Gallant, P E AU - Brightman, M W AU - Winters, C A AU - Reese, T S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Spinules KW - N-Methyl-D-aspartic acid KW - Synapses KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Depolarization+and+NMDA+Induce+Spinule+Formation+at+Hippocampal+CA1+Synapses&rft.au=Tao-Cheng%2C+J.-H.%3BDosemeci%2C+A%3BGallant%2C+P+E%3BBrightman%2C+M+W%3BWinters%2C+C+A%3BReese%2C+T+S&rft.aulast=Tao-Cheng&rft.aufirst=J.-H.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reduced Gray Matter Volume and Frontal Lobe Asymmetry in High Functioning Autism Spectrum Disorders T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39580653; 4711898 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Wallace, G L AU - Silvers, J A AU - Martin, A AU - Giedd, J N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Autism KW - Frontal lobe KW - Substantia grisea KW - Asymmetry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Reduced+Gray+Matter+Volume+and+Frontal+Lobe+Asymmetry+in+High+Functioning+Autism+Spectrum+Disorders&rft.au=Wallace%2C+G+L%3BSilvers%2C+J+A%3BMartin%2C+A%3BGiedd%2C+J+N&rft.aulast=Wallace&rft.aufirst=G&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Definition Autoantibody Profiling for Diagnosis of Stiff Person Syndrome and Other Neurological Diseases T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39580596; 4708613 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Burbelo, P D AU - Groot, S AU - Yang, H.-Y. T. AU - Dalakas, M AU - Iadarola, M J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurological diseases KW - Autoantibodies KW - Profiling KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580596?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=High+Definition+Autoantibody+Profiling+for+Diagnosis+of+Stiff+Person+Syndrome+and+Other+Neurological+Diseases&rft.au=Burbelo%2C+P+D%3BGroot%2C+S%3BYang%2C+H.-Y.+T.%3BDalakas%2C+M%3BIadarola%2C+M+J&rft.aulast=Burbelo&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Domain-Specific Memory Impairment in Autism T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39580482; 4711911 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Snow, J AU - Dolan, L A AU - Wallace, G L AU - Levy, I F AU - Ingeholm, J E AU - Martin, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Autism KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Domain-Specific+Memory+Impairment+in+Autism&rft.au=Snow%2C+J%3BDolan%2C+L+A%3BWallace%2C+G+L%3BLevy%2C+I+F%3BIngeholm%2C+J+E%3BMartin%2C+A&rft.aulast=Snow&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intra-Dimensional/Extra-Dimensional Set-Shifting Ability in Healthy Siblings of Schizophrenic Patients T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39580480; 4717718 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ceaser, A AU - Goldberg, T AU - Egan, M AU - Weinberger, D AU - Gold, J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Siblings KW - Schizophrenia KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39580480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Intra-Dimensional%2FExtra-Dimensional+Set-Shifting+Ability+in+Healthy+Siblings+of+Schizophrenic+Patients&rft.au=Ceaser%2C+A%3BGoldberg%2C+T%3BEgan%2C+M%3BWeinberger%2C+D%3BGold%2C+J&rft.aulast=Ceaser&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cannabinoid Receptors Modulate GABAergic Feedback Inhibition in Rat Retina T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39579721; 4711109 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Chavez, A E AU - Munoz, A Palacios AU - Diamond, J S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Retina KW - Feedback inhibition KW - Cannabinoid receptors KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cannabinoid+Receptors+Modulate+GABAergic+Feedback+Inhibition+in+Rat+Retina&rft.au=Chavez%2C+A+E%3BMunoz%2C+A+Palacios%3BDiamond%2C+J+S&rft.aulast=Chavez&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Schaffer Collateral Synaptic Transmission by High Concentration Choline Involves Muscarinic Receptor Activation T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39579642; 4712131 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tu, B. AU - Yakel, J L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Receptor mechanisms KW - Choline KW - Synaptic transmission KW - Acetylcholine receptors (muscarinic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39579642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+Schaffer+Collateral+Synaptic+Transmission+by+High+Concentration+Choline+Involves+Muscarinic+Receptor+Activation&rft.au=Tu%2C+B.%3BYakel%2C+J+L&rft.aulast=Tu&rft.aufirst=B.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of EtOH-dependent PKCU Interacting Proteins and their Potential Role in Modulating PKCU Activity T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39577685; 4710957 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rex, E B AU - Rankin, M L AU - Ariano, M A AU - Sibley, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Protein kinase C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577685?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+EtOH-dependent+PKCU+Interacting+Proteins+and+their+Potential+Role+in+Modulating+PKCU+Activity&rft.au=Rex%2C+E+B%3BRankin%2C+M+L%3BAriano%2C+M+A%3BSibley%2C+D+R&rft.aulast=Rex&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of NMDA Receptor Endocytosis by Differential Combinations of NR2 Subunits T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39577457; 4710910 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tang, T T AU - Roche, K W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Endocytosis KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39577457?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+NMDA+Receptor+Endocytosis+by+Differential+Combinations+of+NR2+Subunits&rft.au=Tang%2C+T+T%3BRoche%2C+K+W&rft.aulast=Tang&rft.aufirst=T&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal NF-kappaB Activity: Regulation of Constitutive p65 Phosphorylation in Primary Neurons by Glutamate, Calcium Flux, and the Kinase Inhibitor H89 T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39576425; 4712230 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rathore, P AU - Listwak, S J AU - Herkenham, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Calcium KW - Glutamic acid KW - NF-B protein KW - Phosphorylation KW - Neurons KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576425?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+NF-kappaB+Activity%3A+Regulation+of+Constitutive+p65+Phosphorylation+in+Primary+Neurons+by+Glutamate%2C+Calcium+Flux%2C+and+the+Kinase+Inhibitor+H89&rft.au=Rathore%2C+P%3BListwak%2C+S+J%3BHerkenham%2C+M&rft.aulast=Rathore&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Dendritic Excitability by Activity-Dependent Trafficking of the A-Type K+ Channel Subunit Kv4.2 in Hippocampal Neurons T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39576307; 4718094 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Kim, J AU - Jung, S.-C. AU - Clemens, A M AU - Petralia, R S AU - Hoffman, D A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Potassium channels KW - Potassium channels (voltage-gated) KW - Hippocampus KW - Excitability KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+Dendritic+Excitability+by+Activity-Dependent+Trafficking+of+the+A-Type+K%2B+Channel+Subunit+Kv4.2+in+Hippocampal+Neurons&rft.au=Kim%2C+J%3BJung%2C+S.-C.%3BClemens%2C+A+M%3BPetralia%2C+R+S%3BHoffman%2C+D+A&rft.aulast=Kim&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Context-Sensitive Learning of Motivational Values Gives Rise to Framing in Monkeys T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39576139; 4720115 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Camera, G La AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39576139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Context-Sensitive+Learning+of+Motivational+Values+Gives+Rise+to+Framing+in+Monkeys&rft.au=Camera%2C+G+La%3BRichmond%2C+B+J&rft.aulast=Camera&rft.aufirst=G&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Postsynaptic Endocannabinoid Release during Retrograde Synaptic Depression in Striatum T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39575191; 4704940 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Adermark, L AU - Lovinger, D M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Depression KW - Cannabinoids KW - Neostriatum KW - Synaptic depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39575191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mechanisms+of+Postsynaptic+Endocannabinoid+Release+during+Retrograde+Synaptic+Depression+in+Striatum&rft.au=Adermark%2C+L%3BLovinger%2C+D+M&rft.aulast=Adermark&rft.aufirst=L&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adult Neurogenesis in Heterozygous bcl-2 KO Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39573608; 4706193 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Schloesser, R J AU - Lednak, J B AU - Chen, G AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Bcl-2 protein KW - Neurogenesis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39573608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Adult+Neurogenesis+in+Heterozygous+bcl-2+KO+Mice&rft.au=Schloesser%2C+R+J%3BLednak%2C+J+B%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Schloesser&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does the SMA Contribute to Encode a Sequence of Movements during Intermanual Transfer of Sequence Knowledge? T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39572742; 4705608 DE: JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tanaka, S AU - Perez, M A AU - Wise, S P AU - Willingham, D T AU - Cohen, L G Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39572742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Does+the+SMA+Contribute+to+Encode+a+Sequence+of+Movements+during+Intermanual+Transfer+of+Sequence+Knowledge%3F&rft.au=Tanaka%2C+S%3BPerez%2C+M+A%3BWise%2C+S+P%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Tanaka&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Color Coding in the Light Responses of Zebrafish Retinal Horizontal Cells T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39572072; 4707028 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Nelson, R F AU - Connaughton, V P Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Horizontal cells KW - Color vision KW - Light effects KW - Freshwater fish KW - Retina KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39572072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Color+Coding+in+the+Light+Responses+of+Zebrafish+Retinal+Horizontal+Cells&rft.au=Nelson%2C+R+F%3BConnaughton%2C+V+P&rft.aulast=Nelson&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bcl-2 Mediated Enhancement of Mitochondrial Function by Lithium and Valproate T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39571273; 4706196 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Wang, Y AU - Bachmann, R F AU - Yuan, P AU - Zhou, R AU - Li, X. AU - Chen, G AU - Du, J. AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Lithium KW - Bcl-2 protein KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39571273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Bcl-2+Mediated+Enhancement+of+Mitochondrial+Function+by+Lithium+and+Valproate&rft.au=Wang%2C+Y%3BBachmann%2C+R+F%3BYuan%2C+P%3BZhou%2C+R%3BLi%2C+X.%3BChen%2C+G%3BDu%2C+J.%3BManji%2C+H+K&rft.aulast=Wang&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mood Stabilizer-induced Changes in the Postsynaptic Density Proteome T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39571233; 4706192 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Catapano, L A AU - Nanavati, D AU - Chen, G AU - Markey, S P AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mood KW - Postsynaptic density KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39571233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Mood+Stabilizer-induced+Changes+in+the+Postsynaptic+Density+Proteome&rft.au=Catapano%2C+L+A%3BNanavati%2C+D%3BChen%2C+G%3BMarkey%2C+S+P%3BManji%2C+H+K&rft.aulast=Catapano&rft.aufirst=L&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Determinants of the Purinergic P2X sub(7) Ion Pore Dilation T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39570796; 4708911 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Yan, Z AU - Li, S. AU - Liang, Z AU - Stojilkovic, S S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Pores KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39570796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Structural+Determinants+of+the+Purinergic+P2X+sub%287%29+Ion+Pore+Dilation&rft.au=Yan%2C+Z%3BLi%2C+S.%3BLiang%2C+Z%3BStojilkovic%2C+S+S&rft.aulast=Yan&rft.aufirst=Z&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Learning Multiple Spatial Environments Enhances the Activation of Young Neurons in the Adult Brain T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39570488; 4708791 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Snyder, J S AU - Cameron, H A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Spatial memory KW - Spatial discrimination learning KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39570488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Learning+Multiple+Spatial+Environments+Enhances+the+Activation+of+Young+Neurons+in+the+Adult+Brain&rft.au=Snyder%2C+J+S%3BCameron%2C+H+A&rft.aulast=Snyder&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rule-based Categorization and Extra-dimensional Set Shifting without Lateral Prefrontal Cortex in Monkeys T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39570021; 4716514 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Lerchner, A AU - Minamimoto, T AU - Soucy, D P AU - Saunders, R AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39570021?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rule-based+Categorization+and+Extra-dimensional+Set+Shifting+without+Lateral+Prefrontal+Cortex+in+Monkeys&rft.au=Lerchner%2C+A%3BMinamimoto%2C+T%3BSoucy%2C+D+P%3BSaunders%2C+R%3BRichmond%2C+B+J&rft.aulast=Lerchner&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of COMT Genotype on MEG Activation during a Working Memory Task T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39569815; 4716450 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Coppola, R AU - Carver, F W AU - Kirchberg, B K AU - Mitchell-Francis, J AU - Holroyd, T O AU - Kolachana, B AU - Weinberger, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Genotypes KW - Short term memory KW - Magnetoencephalography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39569815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+COMT+Genotype+on+MEG+Activation+during+a+Working+Memory+Task&rft.au=Coppola%2C+R%3BCarver%2C+F+W%3BKirchberg%2C+B+K%3BMitchell-Francis%2C+J%3BHolroyd%2C+T+O%3BKolachana%2C+B%3BWeinberger%2C+D+R&rft.aulast=Coppola&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Plasma Catecholamine Precursor Depletion on Incentive-elicited Brain Activation: An fMRI Study T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568604; 4711378 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Smith, A R AU - Bjork, J M AU - Hommer, D W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain mapping KW - Catecholamines KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Plasma+Catecholamine+Precursor+Depletion+on+Incentive-elicited+Brain+Activation%3A+An+fMRI+Study&rft.au=Smith%2C+A+R%3BBjork%2C+J+M%3BHommer%2C+D+W&rft.aulast=Smith&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cingulate Cortex Ablation does not Impair Reward Evaluation in Monkey T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568417; 4717942 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ravel, S P AU - Minamimoto, T AU - Camera, G La AU - Saunders, R C AU - Richmond, B J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Reinforcement KW - Cortex (cingulate) KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cingulate+Cortex+Ablation+does+not+Impair+Reward+Evaluation+in+Monkey&rft.au=Ravel%2C+S+P%3BMinamimoto%2C+T%3BCamera%2C+G+La%3BSaunders%2C+R+C%3BRichmond%2C+B+J&rft.aulast=Ravel&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bcl-2 Polymorphisms Associated with Bipolar Disorder Regulate bcl-2 mRNA/Protein Expression and Cellular Resilience T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568407; 4706194 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Yuan, P AU - Baum, A E AU - Zhou, R AU - Wang, Y AU - Maric, D AU - Mcmahon, F J AU - Chen, G AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Bcl-2 protein KW - Gene expression KW - Bipolar disorder KW - Gene polymorphism KW - MRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Bcl-2+Polymorphisms+Associated+with+Bipolar+Disorder+Regulate+bcl-2+mRNA%2FProtein+Expression+and+Cellular+Resilience&rft.au=Yuan%2C+P%3BBaum%2C+A+E%3BZhou%2C+R%3BWang%2C+Y%3BMaric%2C+D%3BMcmahon%2C+F+J%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Yuan&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of the Neural Representation of Social and Non-social Hierarchies in Humans T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568308; 4708146 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zink, C F AU - Tong, Y AU - Chen, Q AU - Hakimi, S AU - Rainey, C AU - Stein, J AU - Laumann, T AU - Kempf, L AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Social hierarchy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Comparison+of+the+Neural+Representation+of+Social+and+Non-social+Hierarchies+in+Humans&rft.au=Zink%2C+C+F%3BTong%2C+Y%3BChen%2C+Q%3BHakimi%2C+S%3BRainey%2C+C%3BStein%2C+J%3BLaumann%2C+T%3BKempf%2C+L%3BMeyer-Lindenberg%2C+A&rft.aulast=Zink&rft.aufirst=C&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Region Epigenetic Assessment in Rats Treated Chronically with Methamphetamine T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568087; 4712701 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Dunn, J J AU - Volkow, N D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Rats KW - Epigenetics KW - Methamphetamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brain+Region+Epigenetic+Assessment+in+Rats+Treated+Chronically+with+Methamphetamine&rft.au=Thanos%2C+P+K%3BDunn%2C+J+J%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NRG1 and ErbB4: The PI3K Pathway as an Integrator of Altered Inputs Related to Genetic Risk for Schizophrenia T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39568075; 4708094 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Law, A J AU - Wang, Y AU - Sei, Y AU - Harrison, P J AU - Kleinman, J E AU - Hyde, T M AU - Weinberger, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Schizophrenia KW - 1-Phosphatidylinositol 3-kinase KW - ErbB-2 protein KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39568075?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NRG1+and+ErbB4%3A+The+PI3K+Pathway+as+an+Integrator+of+Altered+Inputs+Related+to+Genetic+Risk+for+Schizophrenia&rft.au=Law%2C+A+J%3BWang%2C+Y%3BSei%2C+Y%3BHarrison%2C+P+J%3BKleinman%2C+J+E%3BHyde%2C+T+M%3BWeinberger%2C+D+R&rft.aulast=Law&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Working Memory Inefficiency in Depression as Revealed by fMRI T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39567853; 4717719 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Higier, R G AU - Brooke, J K AU - Buckholtz, J W AU - Tan, H Y AU - Mattay, V S AU - Weinberger, D R AU - Callicott, J H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Depression KW - Functional magnetic resonance imaging KW - Short term memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39567853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Working+Memory+Inefficiency+in+Depression+as+Revealed+by+fMRI&rft.au=Higier%2C+R+G%3BBrooke%2C+J+K%3BBuckholtz%2C+J+W%3BTan%2C+H+Y%3BMattay%2C+V+S%3BWeinberger%2C+D+R%3BCallicott%2C+J+H&rft.aulast=Higier&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adaptive Dynamics on different Time Scales Throughout a Sensory Pathway Enhances Efficient Coding of Salient Features T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39566531; 4709146 DE: JF - 2007 Annual Meeting of the Society for Neuroscience AU - Joseph, J AU - Daffron, S B AU - Stopfer, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39566531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Adaptive+Dynamics+on+different+Time+Scales+Throughout+a+Sensory+Pathway+Enhances+Efficient+Coding+of+Salient+Features&rft.au=Joseph%2C+J%3BDaffron%2C+S+B%3BStopfer%2C+M&rft.aulast=Joseph&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Native and Recombinant Nicotinic Acetylcholine Receptors by MARCKS Peptides T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39565428; 4709630 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gay, E A AU - Klein, R C AU - Blackshear, P J AU - Yakel, J L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Acetylcholine receptors (nicotinic) KW - MARCKS protein KW - Neurotransmitters KW - Peptides KW - Recombinants KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39565428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inhibition+of+Native+and+Recombinant+Nicotinic+Acetylcholine+Receptors+by+MARCKS+Peptides&rft.au=Gay%2C+E+A%3BKlein%2C+R+C%3BBlackshear%2C+P+J%3BYakel%2C+J+L&rft.aulast=Gay&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional a7 Nicotinic Acetylcholine Receptors Localize to Soma and Proximal Dendrites in the Rat Substantia Nigra Pars Reticulata T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39565342; 4709603 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Poisik, O V AU - Yakel, J L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Dendrites KW - Acetylcholine receptors (nicotinic) KW - Substantia nigra pars reticulata KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39565342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+a7+Nicotinic+Acetylcholine+Receptors+Localize+to+Soma+and+Proximal+Dendrites+in+the+Rat+Substantia+Nigra+Pars+Reticulata&rft.au=Poisik%2C+O+V%3BYakel%2C+J+L&rft.aulast=Poisik&rft.aufirst=O&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lack of Neuronal M3 Muscarinic Acetylcholine Receptors Results in Dwarfism in Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39565230; 4707747 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gautam, D AU - Jeon, J AU - Starost, M F AU - Han, S.-J. AU - Hamdan, F AU - Gavrilova, O AU - Parlow, A F AU - Cui, Y AU - Wess, J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Acetylcholine receptors (muscarinic) KW - Dwarfism KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39565230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lack+of+Neuronal+M3+Muscarinic+Acetylcholine+Receptors+Results+in+Dwarfism+in+Mice&rft.au=Gautam%2C+D%3BJeon%2C+J%3BStarost%2C+M+F%3BHan%2C+S.-J.%3BHamdan%2C+F%3BGavrilova%2C+O%3BParlow%2C+A+F%3BCui%2C+Y%3BWess%2C+J&rft.aulast=Gautam&rft.aufirst=D&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetically-engineered Inducible Cell Ablation Mice Selective for Forebrain GABAergic Cells T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39565145; 4711400 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Belforte, J E AU - Kunos, G AU - Nakazawa, K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Forebrain KW - G-Aminobutyric acid KW - Ablation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39565145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetically-engineered+Inducible+Cell+Ablation+Mice+Selective+for+Forebrain+GABAergic+Cells&rft.au=Belforte%2C+J+E%3BKunos%2C+G%3BNakazawa%2C+K&rft.aulast=Belforte&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Cloning of a Brain-Specific, Developmentally Regulated NRG1 Isoform (Type IV) and Identification of a Functional Promoter Variant Associated with Schizophrenia T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39564721; 4709823 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Wang, Y AU - Tan, W AU - Gold, B AU - Chen, J AU - Dean, M AU - Harrison, P J AU - Weinberger, D R AU - Law, A J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Schizophrenia KW - Promoters KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39564721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Cloning+of+a+Brain-Specific%2C+Developmentally+Regulated+NRG1+Isoform+%28Type+IV%29+and+Identification+of+a+Functional+Promoter+Variant+Associated+with+Schizophrenia&rft.au=Wang%2C+Y%3BTan%2C+W%3BGold%2C+B%3BChen%2C+J%3BDean%2C+M%3BHarrison%2C+P+J%3BWeinberger%2C+D+R%3BLaw%2C+A+J&rft.aulast=Wang&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variation in CAMK2A Affects Brain Structure and Function in Normal Controls T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39562952; 4712626 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rasetti, R AU - Malone, C AU - Mattay, V S AU - Rivero, O AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Straub, R E AU - Weinberger, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Genetic diversity KW - Structure-function relationships KW - Functional anatomy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39562952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+Variation+in+CAMK2A+Affects+Brain+Structure+and+Function+in+Normal+Controls&rft.au=Rasetti%2C+R%3BMalone%2C+C%3BMattay%2C+V+S%3BRivero%2C+O%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BStraub%2C+R+E%3BWeinberger%2C+D+R&rft.aulast=Rasetti&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NKCC1 and KCC2 Cation-Chloride Co-Transporter Expression in Human Brain: Transitional Changes during Fetal Development T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39562847; 4712603 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Metitiri, O E AU - Hyde, T M AU - Lipska, B K AU - Mitkus, S N AU - Mathew, S V AU - Herman, M M AU - Kleinman, J E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - Potassium-chloride cotransporter KW - Fetuses KW - Chloride transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39562847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NKCC1+and+KCC2+Cation-Chloride+Co-Transporter+Expression+in+Human+Brain%3A+Transitional+Changes+during+Fetal+Development&rft.au=Metitiri%2C+O+E%3BHyde%2C+T+M%3BLipska%2C+B+K%3BMitkus%2C+S+N%3BMathew%2C+S+V%3BHerman%2C+M+M%3BKleinman%2C+J+E&rft.aulast=Metitiri&rft.aufirst=O&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA di-heteromeric Receptor Populations and Associated Proteins in Rat Hippocampus T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39562119; 4710909 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Al-Hallaq, R A AU - Conrads, T P AU - Veenstra, T D AU - Wenthold, R J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - N-Methyl-D-aspartic acid receptors KW - Hippocampus KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39562119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NMDA+di-heteromeric+Receptor+Populations+and+Associated+Proteins+in+Rat+Hippocampus&rft.au=Al-Hallaq%2C+R+A%3BConrads%2C+T+P%3BVeenstra%2C+T+D%3BWenthold%2C+R+J&rft.aulast=Al-Hallaq&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Circular Inference in Neuroscience: the Dangers of Double Dipping T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39560618; 4707917 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Baker, C I AU - Simmons, W K AU - Bellgowan, P S AU - Kriegeskorte, N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hazards KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39560618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Circular+Inference+in+Neuroscience%3A+the+Dangers+of+Double+Dipping&rft.au=Baker%2C+C+I%3BSimmons%2C+W+K%3BBellgowan%2C+P+S%3BKriegeskorte%2C+N&rft.aulast=Baker&rft.aufirst=C&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation and Initial Phenotypic Analysis of Mutant Mice Lacking M4 Muscarinic Acetylcholine Receptors in D1 Dopamine-Receptor Expressing Cells T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39559876; 4707748 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Jeon, J AU - Woertwein, G AU - Fink-Jensen, A AU - Woldbye, D P D AU - Schulein, C AU - Schuetz, G AU - Davis, A A AU - Rees, H D AU - Levey, A I AU - Li, C. AU - Deng, C AU - Cui, Y AU - Wess, J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Mutants KW - Acetylcholine receptors (muscarinic) KW - Neurotransmitters KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39559876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Generation+and+Initial+Phenotypic+Analysis+of+Mutant+Mice+Lacking+M4+Muscarinic+Acetylcholine+Receptors+in+D1+Dopamine-Receptor+Expressing+Cells&rft.au=Jeon%2C+J%3BWoertwein%2C+G%3BFink-Jensen%2C+A%3BWoldbye%2C+D+P+D%3BSchulein%2C+C%3BSchuetz%2C+G%3BDavis%2C+A+A%3BRees%2C+H+D%3BLevey%2C+A+I%3BLi%2C+C.%3BDeng%2C+C%3BCui%2C+Y%3BWess%2C+J&rft.aulast=Jeon&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Nontraditional Opioid Analgesics Tramadol and Meperidine, but not Morphine, Induce an Exaggerated Serotonin Syndrome in Serotonin Transporter (SERT)-Deficient Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39559274; 4709873 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Fox, M A AU - Jensen, C L AU - Murphy, D L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Serotonin transporter KW - Analgesics KW - Tramadol KW - Serotonin KW - Opioids KW - Morphine KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39559274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Nontraditional+Opioid+Analgesics+Tramadol+and+Meperidine%2C+but+not+Morphine%2C+Induce+an+Exaggerated+Serotonin+Syndrome+in+Serotonin+Transporter+%28SERT%29-Deficient+Mice&rft.au=Fox%2C+M+A%3BJensen%2C+C+L%3BMurphy%2C+D+L&rft.aulast=Fox&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Involvement of the Supplementary Motor Area and Thalamus in Transfer of Motor Learning in Healthy Subjects T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39558411; 4705609 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Perez, M A AU - Tanaka, S AU - Wise, S P AU - Sadato, N AU - Tanabe, H AU - Willingham, D T AU - Cohen, L G Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Supplementary motor area KW - Motor skill learning KW - Thalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Involvement+of+the+Supplementary+Motor+Area+and+Thalamus+in+Transfer+of+Motor+Learning+in+Healthy+Subjects&rft.au=Perez%2C+M+A%3BTanaka%2C+S%3BWise%2C+S+P%3BSadato%2C+N%3BTanabe%2C+H%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Perez&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selectivity and Temporal Resolution of Neural Coding in Rostral Auditory Cortex of Macaques during a Working Memory Task T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39558190; 4705656 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Scott, B H AU - Kloth, A D AU - Yin, P AU - Mishkin, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (temporal) KW - Short term memory KW - Coding KW - Cortex (auditory) KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39558190?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selectivity+and+Temporal+Resolution+of+Neural+Coding+in+Rostral+Auditory+Cortex+of+Macaques+during+a+Working+Memory+Task&rft.au=Scott%2C+B+H%3BKloth%2C+A+D%3BYin%2C+P%3BMishkin%2C+M&rft.aulast=Scott&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuromodulation of Cognitive Memory vs. Habit Formation T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39557775; 4716518 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Turchi, J N AU - Reoli, R AU - Saunders, R C AU - Mishkin, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neuromodulation KW - Cognitive ability KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39557775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuromodulation+of+Cognitive+Memory+vs.+Habit+Formation&rft.au=Turchi%2C+J+N%3BReoli%2C+R%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Turchi&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Heterogeneity in CA2: Plasticity, Dendritic Structure, and Gene Expression T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39557290; 4704914 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zhao, M AU - Saha, R N AU - Dudek, S M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Gene expression KW - Plasticity (dendritic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39557290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Heterogeneity+in+CA2%3A+Plasticity%2C+Dendritic+Structure%2C+and+Gene+Expression&rft.au=Zhao%2C+M%3BSaha%2C+R+N%3BDudek%2C+S+M&rft.aulast=Zhao&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GSK-3b Modulates AMPA Receptor Internalization and Synaptic Plasticity: Relevance for Mood Disorders T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39556985; 4706189 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Du, J. AU - Wei, Y AU - Wang, Y AU - Malkesman, O AU - Chen, G AU - Manji, H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Mood KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39556985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GSK-3b+Modulates+AMPA+Receptor+Internalization+and+Synaptic+Plasticity%3A+Relevance+for+Mood+Disorders&rft.au=Du%2C+J.%3BWei%2C+Y%3BWang%2C+Y%3BMalkesman%2C+O%3BChen%2C+G%3BManji%2C+H&rft.aulast=Du&rft.aufirst=J.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auditory Response Properties in the Rostral and Caudal Stations of the Auditory Stimulus Processing Stream of the Macaque Superior Temporal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39556118; 4706447 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Kikuchi, Y AU - Horwitz, B AU - Mishkin, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (temporal) KW - Cortex (auditory) KW - Information processing KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39556118?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Auditory+Response+Properties+in+the+Rostral+and+Caudal+Stations+of+the+Auditory+Stimulus+Processing+Stream+of+the+Macaque+Superior+Temporal+Cortex&rft.au=Kikuchi%2C+Y%3BHorwitz%2C+B%3BMishkin%2C+M&rft.aulast=Kikuchi&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Multi Adaptor Protein Fe65 Modulates GnRH-1 Neuorendocrine Cell Fate Specification T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39555381; 4708767 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Forni, P E AU - Fornaro, M AU - Wray, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cell fate KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39555381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Multi+Adaptor+Protein+Fe65+Modulates+GnRH-1+Neuorendocrine+Cell+Fate+Specification&rft.au=Forni%2C+P+E%3BFornaro%2C+M%3BWray%2C+S&rft.aulast=Forni&rft.aufirst=P&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Mood Stabilizers Lithium and Valproic Acid on Adult Neurogenesis in Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39553887; 4706201 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Lednak, J B AU - Schloesser, R J AU - Khairova, R AU - Creson, T K AU - Chen, G AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Lithium KW - Mice KW - Valproic acid KW - Neurogenesis KW - Mood KW - Stabilizers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39553887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Mood+Stabilizers+Lithium+and+Valproic+Acid+on+Adult+Neurogenesis+in+Mice&rft.au=Lednak%2C+J+B%3BSchloesser%2C+R+J%3BKhairova%2C+R%3BCreson%2C+T+K%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Lednak&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamics of Mitochondrial Function Regulated by High and Low Doses of Corticosterone: Impact on Animal Models of Chronic Stress T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39553821; 4706198 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Machado-Vieira, R AU - Du, J. AU - Wang, Y AU - Wei, Y AU - Falke, C AU - Chen, J AU - Blumenthal, R AU - Zhou, R AU - Yuan, P AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Animal models KW - Stress KW - Mitochondria KW - Corticosterone KW - Ecosystem disturbance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39553821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamics+of+Mitochondrial+Function+Regulated+by+High+and+Low+Doses+of+Corticosterone%3A+Impact+on+Animal+Models+of+Chronic+Stress&rft.au=Machado-Vieira%2C+R%3BDu%2C+J.%3BWang%2C+Y%3BWei%2C+Y%3BFalke%2C+C%3BChen%2C+J%3BBlumenthal%2C+R%3BZhou%2C+R%3BYuan%2C+P%3BManji%2C+H+K&rft.aulast=Machado-Vieira&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Disparity Vergence Eye Movements Using Oblique Gratings T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39552064; 4709239 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rambold, H AU - Miles, F A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Eye KW - Vergence eye movements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39552064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Human+Disparity+Vergence+Eye+Movements+Using+Oblique+Gratings&rft.au=Rambold%2C+H%3BMiles%2C+F+A&rft.aulast=Rambold&rft.aufirst=H&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Activation of A-delta and C-fiber Primary Afferents Discloses a TRPV1-sensitive Population of A-delta Fibers T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39551062; 4709345 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Iadarola, M J AU - Keller, J M AU - Mitchell, K AU - Yaskovich, R AU - Nemenov, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Fibers KW - Sensory neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39551062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+Activation+of+A-delta+and+C-fiber+Primary+Afferents+Discloses+a+TRPV1-sensitive+Population+of+A-delta+Fibers&rft.au=Iadarola%2C+M+J%3BKeller%2C+J+M%3BMitchell%2C+K%3BYaskovich%2C+R%3BNemenov%2C+M&rft.aulast=Iadarola&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Oligodendrocyte-Related Genes CNP and OLIG2 is Associated with Schizophrenia Risk Polymorphisms T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39550356; 4712612 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Mitkus, S N AU - Hyde, T M AU - Caruso, M AU - Vakkalanka, R AU - Kolachana, B AU - Weinberger, D R AU - Kleinman, J E AU - Lipska, B K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Schizophrenia KW - Mental disorders KW - Gene polymorphism KW - Olig2 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39550356?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+of+Oligodendrocyte-Related+Genes+CNP+and+OLIG2+is+Associated+with+Schizophrenia+Risk+Polymorphisms&rft.au=Mitkus%2C+S+N%3BHyde%2C+T+M%3BCaruso%2C+M%3BVakkalanka%2C+R%3BKolachana%2C+B%3BWeinberger%2C+D+R%3BKleinman%2C+J+E%3BLipska%2C+B+K&rft.aulast=Mitkus&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Novel DISC1 Transcripts in Human Brain T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39547791; 4709832 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Nakata, K AU - Lipska, B K AU - Hyde, T M AU - Weinberger, D R AU - Kleinman, J E Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain KW - DISC1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39547791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+of+Novel+DISC1+Transcripts+in+Human+Brain&rft.au=Nakata%2C+K%3BLipska%2C+B+K%3BHyde%2C+T+M%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Nakata&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Neuroimaging of Overt Verbal Fluency in Adolescents with Autism Spectrum Disorders T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39545642; 4705219 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Birn, R M AU - Kenworthy, L AU - Case, L K AU - Jones, T B AU - Milleville, S C AU - Martin, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Adolescents KW - Autism KW - Neuroimaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39545642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Functional+Neuroimaging+of+Overt+Verbal+Fluency+in+Adolescents+with+Autism+Spectrum+Disorders&rft.au=Birn%2C+R+M%3BKenworthy%2C+L%3BCase%2C+L+K%3BJones%2C+T+B%3BMilleville%2C+S+C%3BMartin%2C+A&rft.aulast=Birn&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spike-field Coherence Across Areas V2 and V4 during Selective Visual Attention T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39544830; 4705715 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Landman, R AU - Desimone, R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Attention KW - Visual perception KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39544830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Spike-field+Coherence+Across+Areas+V2+and+V4+during+Selective+Visual+Attention&rft.au=Landman%2C+R%3BDesimone%2C+R&rft.aulast=Landman&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Auditory Feedback of Vocalization in Children with Autistic Disorders T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39544548; 4705647 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gunji, A AU - Koyama, S AU - Houde, J F AU - Toyomura, A AU - Ogawa, A AU - Senju, A AU - Tojo, Y Yoshikuni AU - Kaga, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Volatile organic compounds KW - Children KW - Autism KW - Auditory stimuli KW - Feedback KW - Vocalization behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39544548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Auditory+Feedback+of+Vocalization+in+Children+with+Autistic+Disorders&rft.au=Gunji%2C+A%3BKoyama%2C+S%3BHoude%2C+J+F%3BToyomura%2C+A%3BOgawa%2C+A%3BSenju%2C+A%3BTojo%2C+Y+Yoshikuni%3BKaga%2C+M&rft.aulast=Gunji&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social Deficits in the BTBR Mouse Model of Autism are Unaffected by Cross-fostering with a different Maternal Strain T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39544486; 4705244 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Yang, M AU - Zhodzishsky, V AU - Crawley, J N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Autism KW - Animal models KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39544486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Social+Deficits+in+the+BTBR+Mouse+Model+of+Autism+are+Unaffected+by+Cross-fostering+with+a+different+Maternal+Strain&rft.au=Yang%2C+M%3BZhodzishsky%2C+V%3BCrawley%2C+J+N&rft.aulast=Yang&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Behavioral Phenotyping of Neuroligin 3 Mutant Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39544434; 4705242 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Chadman, K K AU - Gong, S AU - Kus, L AU - James, J AU - Heintz, N AU - Crawley, J N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Mutants KW - Phenotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39544434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Comprehensive+Behavioral+Phenotyping+of+Neuroligin+3+Mutant+Mice&rft.au=Chadman%2C+K+K%3BGong%2C+S%3BKus%2C+L%3BJames%2C+J%3BHeintz%2C+N%3BCrawley%2C+J+N&rft.aulast=Chadman&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Anandamide Inhibition of 5-HT sub(3A) Receptors is Dependent on Receptor Density T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39544400; 4708920 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Xiong, W AU - Hosoi, M AU - Koo, B.-N. AU - Sun, H AU - Zhang, L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Anandamide KW - Receptor density KW - Serotonin S3 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39544400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Anandamide+Inhibition+of+5-HT+sub%283A%29+Receptors+is+Dependent+on+Receptor+Density&rft.au=Xiong%2C+W%3BHosoi%2C+M%3BKoo%2C+B.-N.%3BSun%2C+H%3BZhang%2C+L&rft.aulast=Xiong&rft.aufirst=W&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Syntabulin-KIF5B-Mediated Axonal Transport Contributes to Activity-Dependent Presynaptic Assembly T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39543814; 4707641 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Cai, Q AU - Pan, P.-Y. AU - Sheng, Z.-H. Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Axonal transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Syntabulin-KIF5B-Mediated+Axonal+Transport+Contributes+to+Activity-Dependent+Presynaptic+Assembly&rft.au=Cai%2C+Q%3BPan%2C+P.-Y.%3BSheng%2C+Z.-H.&rft.aulast=Cai&rft.aufirst=Q&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ranking 96 Object Images by their Activation of FFA T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39543707; 4707140 DE: JF - 2007 Annual Meeting of the Society for Neuroscience AU - Mur, M C AU - Ruff, D AU - Bodurka, J AU - Bandettini, P AU - Kriegeskorte, N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39543707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ranking+96+Object+Images+by+their+Activation+of+FFA&rft.au=Mur%2C+M+C%3BRuff%2C+D%3BBodurka%2C+J%3BBandettini%2C+P%3BKriegeskorte%2C+N&rft.aulast=Mur&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Avalanches during Cortical Development T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39542574; 4709069 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gireesh, E Dharmaraj AU - Plenz, D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Avalanches KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39542574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Avalanches+during+Cortical+Development&rft.au=Gireesh%2C+E+Dharmaraj%3BPlenz%2C+D&rft.aulast=Gireesh&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II AT1 Receptor Blockade Reduces the Innate Inflammatory Response to Lipopolysaccharide in Human Monocytes T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39542087; 4706161 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Larrayoz, I M AU - Benicky, J AU - Zhou, J AU - Sanchez-Lemus, E AU - Murakami, Y AU - Pavel, J AU - De Nicola, A F AU - Saavedra, J M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Monocytes KW - Lipopolysaccharides KW - Inflammation KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39542087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+AT1+Receptor+Blockade+Reduces+the+Innate+Inflammatory+Response+to+Lipopolysaccharide+in+Human+Monocytes&rft.au=Larrayoz%2C+I+M%3BBenicky%2C+J%3BZhou%2C+J%3BSanchez-Lemus%2C+E%3BMurakami%2C+Y%3BPavel%2C+J%3BDe+Nicola%2C+A+F%3BSaavedra%2C+J+M&rft.aulast=Larrayoz&rft.aufirst=I&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activity in Primary Motor Cortices during Force Generation II. Interhemispheric Inhibition T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39539797; 4706721 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Sehm, B S AU - Perez, M A AU - Cohen, L G Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cerebral hemispheres KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39539797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Activity+in+Primary+Motor+Cortices+during+Force+Generation+II.+Interhemispheric+Inhibition&rft.au=Sehm%2C+B+S%3BPerez%2C+M+A%3BCohen%2C+L+G&rft.aulast=Sehm&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Motor Sequence Learning: An fMRI Study using a Novel Graphomotor Paradigm T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39538296; 4714397 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Swett, B A AU - Contreras-Vidal, J L AU - Birn, R AU - Braun, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Motor skill learning KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39538296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Correlates+of+Motor+Sequence+Learning%3A+An+fMRI+Study+using+a+Novel+Graphomotor+Paradigm&rft.au=Swett%2C+B+A%3BContreras-Vidal%2C+J+L%3BBirn%2C+R%3BBraun%2C+A&rft.aulast=Swett&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subregion Specific Striatal Changes during Skill Learning T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39537770; 4716585 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Prasad-Mulcare, S AU - Yin, H H AU - Clouse, E AU - Lovinger, D M AU - Adermark, L AU - Costa, R M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Learning KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Subregion+Specific+Striatal+Changes+during+Skill+Learning&rft.au=Prasad-Mulcare%2C+S%3BYin%2C+H+H%3BClouse%2C+E%3BLovinger%2C+D+M%3BAdermark%2C+L%3BCosta%2C+R+M&rft.aulast=Prasad-Mulcare&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An fMRI Study of Trial by Trial Interaction Effects in Fusiform Gyrus and Amygdala T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39537516; 4714230 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Jansma, J M AU - Hakimi, S AU - Fukunaga, M AU - Duyn, J H AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Amygdala KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39537516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=An+fMRI+Study+of+Trial+by+Trial+Interaction+Effects+in+Fusiform+Gyrus+and+Amygdala&rft.au=Jansma%2C+J+M%3BHakimi%2C+S%3BFukunaga%2C+M%3BDuyn%2C+J+H%3BMeyer-Lindenberg%2C+A&rft.aulast=Jansma&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transcriptional Regulation of Cyclin-dependent Kinase 5 Activator, p35, by Tumor Necrosis Factor-a T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39535870; 4705865 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Utreras, E AU - Pareek, T K AU - Kulkarni, A B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Transcription KW - Tumor necrosis factor-a KW - Cyclin-dependent kinase 5 KW - Gene regulation KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39535870?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Transcriptional+Regulation+of+Cyclin-dependent+Kinase+5+Activator%2C+p35%2C+by+Tumor+Necrosis+Factor-a&rft.au=Utreras%2C+E%3BPareek%2C+T+K%3BKulkarni%2C+A+B&rft.aulast=Utreras&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Dynamics of Glutamate Uptake and NMDA Receptor Activation in Mouse Neonatal Hippocampal Slices T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39535077; 4716890 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Thomas, C G AU - Diamond, J S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Glutamic acid KW - Receptor mechanisms KW - N-Methyl-D-aspartic acid receptors KW - Neonates KW - Brain slice preparation KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39535077?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Dynamics+of+Glutamate+Uptake+and+NMDA+Receptor+Activation+in+Mouse+Neonatal+Hippocampal+Slices&rft.au=Thomas%2C+C+G%3BDiamond%2C+J+S&rft.aulast=Thomas&rft.aufirst=C&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering a Role for Mitochondrial Motility in Axonal Outgrowth during Neuronal Development T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39533968; 4709486 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zyskind, J AU - Kang, J.-S. AU - Sheng, Z Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Motility KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Deciphering+a+Role+for+Mitochondrial+Motility+in+Axonal+Outgrowth+during+Neuronal+Development&rft.au=Zyskind%2C+J%3BKang%2C+J.-S.%3BSheng%2C+Z&rft.aulast=Zyskind&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hyperactivity of GnRH-1 Neurons in Nasal Explants from Mice Lacking Estrogen Receptor Beta T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39533866; 4709456 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Caligioni, C S AU - Wray, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Estrogen receptors KW - Mice KW - Hyperactivity KW - Explants KW - Neurons KW - Sex hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533866?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Hyperactivity+of+GnRH-1+Neurons+in+Nasal+Explants+from+Mice+Lacking+Estrogen+Receptor+Beta&rft.au=Caligioni%2C+C+S%3BWray%2C+S&rft.aulast=Caligioni&rft.aufirst=C&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Involvement of Zebrafish Olfactomedin1 in Eye Development T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39533666; 4707573 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Nakaya, N AU - Takada, Y AU - Tomarev, S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Eye KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Involvement+of+Zebrafish+Olfactomedin1+in+Eye+Development&rft.au=Nakaya%2C+N%3BTakada%2C+Y%3BTomarev%2C+S&rft.aulast=Nakaya&rft.aufirst=N&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI BOLD Responses to Median Nerve Stimulation in Awake Marmosets T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39533172; 4716150 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Stefanovic, B AU - Nascimento, G AU - Silva, A C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Functional magnetic resonance imaging KW - Median nerve KW - Nerves KW - Callithrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39533172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=fMRI+BOLD+Responses+to+Median+Nerve+Stimulation+in+Awake+Marmosets&rft.au=Stefanovic%2C+B%3BNascimento%2C+G%3BSilva%2C+A+C&rft.aulast=Stefanovic&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Mechanism Regulating BDNF Levels in the Brain: BHLHB2 Controls Promoter 4 Activity and Neuronal Excitability T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39531696; 4706041 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Lipsky, R H AU - Jiang, X AU - Tian, F AU - Du, Y. AU - Egan, S AU - Kenney, H AU - Marini, A M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Brain-derived neurotrophic factor KW - Promoters KW - Excitability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+Novel+Mechanism+Regulating+BDNF+Levels+in+the+Brain%3A+BHLHB2+Controls+Promoter+4+Activity+and+Neuronal+Excitability&rft.au=Lipsky%2C+R+H%3BJiang%2C+X%3BTian%2C+F%3BDu%2C+Y.%3BEgan%2C+S%3BKenney%2C+H%3BMarini%2C+A+M&rft.aulast=Lipsky&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social Aggression Following Deletion of BDNF Gene from Hippocampal Area CA3 T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39531569; 4715196 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Morozov, A AU - Chehab, M AU - Ito, W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Aggressive behavior KW - Gene deletion KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Aggressive behaviour KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Social+Aggression+Following+Deletion+of+BDNF+Gene+from+Hippocampal+Area+CA3&rft.au=Morozov%2C+A%3BChehab%2C+M%3BIto%2C+W&rft.aulast=Morozov&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lateral Habenula Neurons Respond to the Negative Value of Rewards and the Positive Value of Elapsed Time T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39531393; 4715174 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bromberg-Martin, E S AU - Matsumoto, M AU - Hikosaka, O Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Reinforcement KW - Neurons KW - Habenula KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531393?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Lateral+Habenula+Neurons+Respond+to+the+Negative+Value+of+Rewards+and+the+Positive+Value+of+Elapsed+Time&rft.au=Bromberg-Martin%2C+E+S%3BMatsumoto%2C+M%3BHikosaka%2C+O&rft.aulast=Bromberg-Martin&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cortical Manganese Uptake in a Non-human Primate Revealed with Magnetic Resonance Imaging T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39531058; 4715285 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bock, N A AU - Silva, A C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Manganese KW - Primates KW - Magnetic resonance imaging KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39531058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cortical+Manganese+Uptake+in+a+Non-human+Primate+Revealed+with+Magnetic+Resonance+Imaging&rft.au=Bock%2C+N+A%3BSilva%2C+A+C&rft.aulast=Bock&rft.aufirst=N&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NeuroMabs: High-quality, Validated Monoclonal Antibodies for Neuroscience Research T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39530978; 4715255 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Gong, B AU - Bradt, B M AU - Kralovich, K R AU - Martin, A D AU - Zhi, M X AU - Cantu, A M AU - Trimmer, J S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Monoclonal antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39530978?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NeuroMabs%3A+High-quality%2C+Validated+Monoclonal+Antibodies+for+Neuroscience+Research&rft.au=Gong%2C+B%3BBradt%2C+B+M%3BKralovich%2C+K+R%3BMartin%2C+A+D%3BZhi%2C+M+X%3BCantu%2C+A+M%3BTrimmer%2C+J+S&rft.aulast=Gong&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive and Emotional Processing of Affective Stimuli in Alcohol-dependent Patients and Healthy Controls T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39529333; 4708699 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Davis, M B AU - Gilman, J M AU - Hommer, D W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Emotions KW - Cognitive ability KW - Information processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39529333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cognitive+and+Emotional+Processing+of+Affective+Stimuli+in+Alcohol-dependent+Patients+and+Healthy+Controls&rft.au=Davis%2C+M+B%3BGilman%2C+J+M%3BHommer%2C+D+W&rft.aulast=Davis&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SALM Family of Adhesion-Like Molecules Forms Heteromeric and Homomeric Complexes T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39528165; 4709553 DE: JF - 2007 Annual Meeting of the Society for Neuroscience AU - Seabold, G K AU - Wang, P Y AU - Chang, K AU - Wang, C.-Y. AU - Wang, Y.-X. AU - Petralia, R S AU - Wenthold, R J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39528165?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+SALM+Family+of+Adhesion-Like+Molecules+Forms+Heteromeric+and+Homomeric+Complexes&rft.au=Seabold%2C+G+K%3BWang%2C+P+Y%3BChang%2C+K%3BWang%2C+C.-Y.%3BWang%2C+Y.-X.%3BPetralia%2C+R+S%3BWenthold%2C+R+J&rft.aulast=Seabold&rft.aufirst=G&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - COXIV mRNA Trafficking in the Axons of Sympathetic Neurons T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39527973; 4709495 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Aschrafi, A AU - Schwechter, A D AU - Gioio, A AU - Kaplan, B B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Sympathetic nerves KW - MRNA KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39527973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=COXIV+mRNA+Trafficking+in+the+Axons+of+Sympathetic+Neurons&rft.au=Aschrafi%2C+A%3BSchwechter%2C+A+D%3BGioio%2C+A%3BKaplan%2C+B+B&rft.aulast=Aschrafi&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Temporal Relationship between Neuronal Activity in the Pedunculopontine Nucleus and the Motor Cortex is Altered in a Rodent Model of Parkinsons Disease T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39524680; 4710125 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Aravamuthan, B R AU - Parr-Brownlie, L C AU - Taylor, J J AU - Bergstrom, D A AU - Walters, J R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rodents KW - Cortex (temporal) KW - Movement disorders KW - Neurodegenerative diseases KW - Animal models KW - Parkinson's disease KW - Pedunculopontine tegmental nucleus KW - Cortex (motor) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39524680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Temporal+Relationship+between+Neuronal+Activity+in+the+Pedunculopontine+Nucleus+and+the+Motor+Cortex+is+Altered+in+a+Rodent+Model+of+Parkinsons+Disease&rft.au=Aravamuthan%2C+B+R%3BParr-Brownlie%2C+L+C%3BTaylor%2C+J+J%3BBergstrom%2C+D+A%3BWalters%2C+J+R&rft.aulast=Aravamuthan&rft.aufirst=B&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bilateral Excitotoxic Lesions of the Amygdala in Rhesus Monkeys Disrupt Emotional Responses to Both Social and Nonsocial Stimuli T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39524169; 4715199 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Murray, E A AU - Gorrin, D P AU - Chudasama, Y Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Lesions KW - Excitotoxicity KW - Amygdala KW - Emotions KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39524169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Bilateral+Excitotoxic+Lesions+of+the+Amygdala+in+Rhesus+Monkeys+Disrupt+Emotional+Responses+to+Both+Social+and+Nonsocial+Stimuli&rft.au=Murray%2C+E+A%3BGorrin%2C+D+P%3BChudasama%2C+Y&rft.aulast=Murray&rft.aufirst=E&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin-25 is a Novel Member of the D sub(1) and D sub(2) Dopamine Receptor Signalplex that Influences Intracellular Receptor Trafficking and Expression T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39523753; 4710958 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Free, R B AU - Hazelwood, L A AU - Cabrera, D M AU - Spalding, H N AU - Sibley, D R Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Protein transport KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39523753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sorting+Nexin-25+is+a+Novel+Member+of+the+D+sub%281%29+and+D+sub%282%29+Dopamine+Receptor+Signalplex+that+Influences+Intracellular+Receptor+Trafficking+and+Expression&rft.au=Free%2C+R+B%3BHazelwood%2C+L+A%3BCabrera%2C+D+M%3BSpalding%2C+H+N%3BSibley%2C+D+R&rft.aulast=Free&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Organization of Synaptic and Extrasynaptic NMDA Receptors T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39523469; 4710911 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Petralia, R S AU - Yi, Z. AU - Wang, Y.-X. AU - Wenthold, R J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - N-Methyl-D-aspartic acid receptors KW - Glutamic acid receptors (ionotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39523469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Organization+of+Synaptic+and+Extrasynaptic+NMDA+Receptors&rft.au=Petralia%2C+R+S%3BYi%2C+Z.%3BWang%2C+Y.-X.%3BWenthold%2C+R+J&rft.aulast=Petralia&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptic Plasticity Changes and Decreases in Slow Wave Activity: Relationship to Preclinical Findings and Clinical Antidepressant Effects of Glutamatergic Modulators T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522907; 4706227 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zarate, C AU - Duncan, W AU - Salvadore, G AU - Tononi, G AU - Manji, H K Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Antidepressants KW - Plasticity (synaptic) KW - Glutamatergic transmission KW - Waves KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synaptic+Plasticity+Changes+and+Decreases+in+Slow+Wave+Activity%3A+Relationship+to+Preclinical+Findings+and+Clinical+Antidepressant+Effects+of+Glutamatergic+Modulators&rft.au=Zarate%2C+C%3BDuncan%2C+W%3BSalvadore%2C+G%3BTononi%2C+G%3BManji%2C+H+K&rft.aulast=Zarate&rft.aufirst=C&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MicroRNA Array Profiling Shows that Members of the let-7 microRNA Family are Robustly Downregulated by the Structurally Distinct Mood Stabilizers Lithium and Valproate T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522766; 4706190 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Zhou, R AU - Yuan, P AU - Wang, Y AU - Elkahloun, A AU - Damschroder-Williams, P AU - Chen, G AU - Manji, H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Lithium KW - MiRNA KW - Mood KW - Stabilizers KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MicroRNA+Array+Profiling+Shows+that+Members+of+the+let-7+microRNA+Family+are+Robustly+Downregulated+by+the+Structurally+Distinct+Mood+Stabilizers+Lithium+and+Valproate&rft.au=Zhou%2C+R%3BYuan%2C+P%3BWang%2C+Y%3BElkahloun%2C+A%3BDamschroder-Williams%2C+P%3BChen%2C+G%3BManji%2C+H&rft.aulast=Zhou&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of NRG1 Type IV mRNAs T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522678; 4712601 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Shamir, A AU - Buonanno, A L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - MRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+and+Characterization+of+NRG1+Type+IV+mRNAs&rft.au=Shamir%2C+A%3BBuonanno%2C+A+L&rft.aulast=Shamir&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Interactions Underlying Goal Selection and Maintenance in Prefrontal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522652; 4720052 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Tsujimoto, S AU - Genovesio, A AU - Wise, S P Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Interactions+Underlying+Goal+Selection+and+Maintenance+in+Prefrontal+Cortex&rft.au=Tsujimoto%2C+S%3BGenovesio%2C+A%3BWise%2C+S+P&rft.aulast=Tsujimoto&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Working Memory Capacity and Individual Response Differences to Increasing Cognitive Load T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522133; 4717716 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Prust, M J AU - Tan, H AU - Mattay, V S AU - Gold, J M AU - Weinberger, D R AU - Callicott III, J H Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Short term memory KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Working+Memory+Capacity+and+Individual+Response+Differences+to+Increasing+Cognitive+Load&rft.au=Prust%2C+M+J%3BTan%2C+H%3BMattay%2C+V+S%3BGold%2C+J+M%3BWeinberger%2C+D+R%3BCallicott+III%2C+J+H&rft.aulast=Prust&rft.aufirst=M&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II AT1 Receptors are Expressed in Isolated Microglia from Normotensive and Spontaneously Hypertensive Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39522090; 4713350 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Murakami, Y AU - Nishioku, T AU - Benicky, J AU - Pavel, J AU - Larrayoz-Roldan, I M AU - Saavedra, J M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Rats KW - Microglia KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39522090?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+AT1+Receptors+are+Expressed+in+Isolated+Microglia+from+Normotensive+and+Spontaneously+Hypertensive+Rats&rft.au=Murakami%2C+Y%3BNishioku%2C+T%3BBenicky%2C+J%3BPavel%2C+J%3BLarrayoz-Roldan%2C+I+M%3BSaavedra%2C+J+M&rft.aulast=Murakami&rft.aufirst=Y&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Shape Selectivity of Field Potentials and Neurons in Macaque Area V4 T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39521477; 4707126 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Mueller, K.-M. AU - Wilke, M AU - Leopold, D A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Neurons KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39521477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Shape+Selectivity+of+Field+Potentials+and+Neurons+in+Macaque+Area+V4&rft.au=Mueller%2C+K.-M.%3BWilke%2C+M%3BLeopold%2C+D+A&rft.aulast=Mueller&rft.aufirst=K.-M.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Determinants of D super(9)-tetrahydrocannabinol-induced Potentiation of Glycine a1 Receptors T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39519286; 4708305 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Koo, B.-N. AU - Xiong, W AU - Zhang, L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Glycine KW - Potentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39519286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Determinants+of+D+super%289%29-tetrahydrocannabinol-induced+Potentiation+of+Glycine+a1+Receptors&rft.au=Koo%2C+B.-N.%3BXiong%2C+W%3BZhang%2C+L&rft.aulast=Koo&rft.aufirst=B.-N.&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Response of a Drosophila Neural Cell Line to the Ecdysone Analogue Muristerone A T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39518955; 4715405 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Rovescalli, A C AU - Billings, E AU - Nirenberg, M W Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Ecdysone KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39518955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cellular+Response+of+a+Drosophila+Neural+Cell+Line+to+the+Ecdysone+Analogue+Muristerone+A&rft.au=Rovescalli%2C+A+C%3BBillings%2C+E%3BNirenberg%2C+M+W&rft.aulast=Rovescalli&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Newly Generated GABAergic Cells in the Adult Primate Prefrontal Cortex T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39516851; 4708795 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Ashrafi, S AU - Runyan, C A AU - Weickert, C Shannon AU - Saunders, R C Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Primates KW - G-Aminobutyric acid KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39516851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Newly+Generated+GABAergic+Cells+in+the+Adult+Primate+Prefrontal+Cortex&rft.au=Ashrafi%2C+S%3BRunyan%2C+C+A%3BWeickert%2C+C+Shannon%3BSaunders%2C+R+C&rft.aulast=Ashrafi&rft.aufirst=S&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PKA Mediates the Activity-Dependent Internalization of Kv4.2 Channels T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39511289; 4707818 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Hammond, R S AU - Hoffman, D A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Channels KW - Protein kinase A KW - Potassium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39511289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PKA+Mediates+the+Activity-Dependent+Internalization+of+Kv4.2+Channels&rft.au=Hammond%2C+R+S%3BHoffman%2C+D+A&rft.aulast=Hammond&rft.aufirst=R&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Evidence of Improved Morris Water Maze Performance in Galanin Receptor Subtype 1 and 2 (GalR1/GalR2) Double Knockout Mice T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39509410; 4707379 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Bailey, K R AU - Freeman, A K AU - Pavlova, M N AU - Rohde, A D AU - Crawley, J N Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Galanin receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39509410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Preliminary+Evidence+of+Improved+Morris+Water+Maze+Performance+in+Galanin+Receptor+Subtype+1+and+2+%28GalR1%2FGalR2%29+Double+Knockout+Mice&rft.au=Bailey%2C+K+R%3BFreeman%2C+A+K%3BPavlova%2C+M+N%3BRohde%2C+A+D%3BCrawley%2C+J+N&rft.aulast=Bailey&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physiological Noise Sources and their Contribution to Bold Signal Fluctuations in the Resting State T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39509047; 4707923 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Laumann, T O AU - Stein, J L AU - Bodurka, J AU - Tong, Y AU - Zink, C AU - Kempf, L AU - Rainey, C AU - Meyer-Lindenberg, A Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39509047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Physiological+Noise+Sources+and+their+Contribution+to+Bold+Signal+Fluctuations+in+the+Resting+State&rft.au=Laumann%2C+T+O%3BStein%2C+J+L%3BBodurka%2C+J%3BTong%2C+Y%3BZink%2C+C%3BKempf%2C+L%3BRainey%2C+C%3BMeyer-Lindenberg%2C+A&rft.aulast=Laumann&rft.aufirst=T&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Systematic Identification of 3UTR Regulatory Elements Involved in Activity-Dependent mRNA Stability and Axonal Transport in Neurons T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39508063; 4707672 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Cohen, J E AU - Lee, P R AU - Fields, R D Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Regulatory sequences KW - MRNA stability KW - Neurons KW - Axonal transport KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39508063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Systematic+Identification+of+3UTR+Regulatory+Elements+Involved+in+Activity-Dependent+mRNA+Stability+and+Axonal+Transport+in+Neurons&rft.au=Cohen%2C+J+E%3BLee%2C+P+R%3BFields%2C+R+D&rft.aulast=Cohen&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Does Dark Phase Testing Offer Advantages in Studying Social Behaviors in Inbred Strains and Knockout Mice? T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39507357; 4705243 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Crawley, J N AU - Zhodzishsky, V AU - Yang, M Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Social behavior KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39507357?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Does+Dark+Phase+Testing+Offer+Advantages+in+Studying+Social+Behaviors+in+Inbred+Strains+and+Knockout+Mice%3F&rft.au=Crawley%2C+J+N%3BZhodzishsky%2C+V%3BYang%2C+M&rft.aulast=Crawley&rft.aufirst=J&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Auditory Processing in Persons with Hearing Loss and Tinnitus: An fMRI Study T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39499995; 4705669 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Husain, F T AU - Pajor, N M AU - Smith, J F AU - Zalewski, C K AU - Rudy, S F AU - Braun, A R AU - Kim, H N AU - Brewer, C C AU - Horwitz, B Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Hearing loss KW - Tinnitus KW - Functional magnetic resonance imaging KW - Information processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39499995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Auditory+Processing+in+Persons+with+Hearing+Loss+and+Tinnitus%3A+An+fMRI+Study&rft.au=Husain%2C+F+T%3BPajor%2C+N+M%3BSmith%2C+J+F%3BZalewski%2C+C+K%3BRudy%2C+S+F%3BBraun%2C+A+R%3BKim%2C+H+N%3BBrewer%2C+C+C%3BHorwitz%2C+B&rft.aulast=Husain&rft.aufirst=F&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Glutamate Transporters Regulate the Dynamics of Glutamatergic Signaling and the Cooperativity between Hippocampal Synapses T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39498911; 4704882 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Scimemi, A AU - Diamond, J S Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Signal transduction KW - Synapses KW - Hippocampus KW - Cooperativity KW - Glutamic acid transporter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39498911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Glutamate+Transporters+Regulate+the+Dynamics+of+Glutamatergic+Signaling+and+the+Cooperativity+between+Hippocampal+Synapses&rft.au=Scimemi%2C+A%3BDiamond%2C+J+S&rft.aulast=Scimemi&rft.aufirst=A&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Manipulation of Catechol-O-Methytransferase (COMT) in Mice Affects Specific Cognitive Processes T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39485422; 4719093 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Papaleo, F AU - Crawley, J N AU - Weinberger, D R AU - Chen, J Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Mice KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39485422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genetic+Manipulation+of+Catechol-O-Methytransferase+%28COMT%29+in+Mice+Affects+Specific+Cognitive+Processes&rft.au=Papaleo%2C+F%3BCrawley%2C+J+N%3BWeinberger%2C+D+R%3BChen%2C+J&rft.aulast=Papaleo&rft.aufirst=F&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Apigenin Induces Apoptotic Death of Proliferating Cells in Human Embryonic Stem Cell Cultures of the Dopaminergic Neuron Differentiation Stage T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39479198; 4710827 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Alavian, K N AU - Pruszak, J AU - Isacson, O Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Stem cells KW - Mortality KW - Apoptosis KW - Cell culture KW - Differentiation KW - Embryo cells KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39479198?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Apigenin+Induces+Apoptotic+Death+of+Proliferating+Cells+in+Human+Embryonic+Stem+Cell+Cultures+of+the+Dopaminergic+Neuron+Differentiation+Stage&rft.au=Alavian%2C+K+N%3BPruszak%2C+J%3BIsacson%2C+O&rft.aulast=Alavian&rft.aufirst=K&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Chronic Changes in Laryngeal Adductor Response Conditioning Three Days after Vocal Fold Inflammation in Rats T2 - 2007 Annual Meeting of the Society for Neuroscience AN - 39461989; 4705962 JF - 2007 Annual Meeting of the Society for Neuroscience AU - Henriquez, V M AU - Feng, X AU - Ludlow, C L Y1 - 2007/11/03/ PY - 2007 DA - 2007 Nov 03 KW - Volatile organic compounds KW - Rats KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39461989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Chronic+Changes+in+Laryngeal+Adductor+Response+Conditioning+Three+Days+after+Vocal+Fold+Inflammation+in+Rats&rft.au=Henriquez%2C+V+M%3BFeng%2C+X%3BLudlow%2C+C+L&rft.aulast=Henriquez&rft.aufirst=V&rft.date=2007-11-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFF8B70E5%2DB7F9%2D4D07% 2DA58A%2DC1068FDE9D25%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Deconstruction of vulnerability to complex diseases: enhanced effect sizes and power of intermediate phenotypes. AN - 68472206; 17982585 AB - The deconstruction of vulnerability to complex disease with the help of intermediate phenotypes, including the heritable and disease-associated endophenotypes, is a legacy of Henri Begleiter. Systematic searches for genes influencing complex disorders, including bipolar disorder, have recently been completed using whole genome association (WGA), identifying a series of validated loci. Using this information, it is possible to compare effect sizes of disease loci discovered in very large samples to the effect sizes of replicated functional loci determining intermediate phenotypes that are of essential interest in psychiatric disorders. It is shown that the genes influencing intermediate phenotypes tend to have a larger effect size. Furthermore, the WGA results reveal that the number of loci of large effect size for complex diseases is limited, and yet multiple functional loci have already been identified for intermediate phenotypes relevant to psychiatric diseases, and without the benefit of WGA. JF - TheScientificWorldJournal AU - Goldman, David AU - Ducci, Francesca AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. dgneuro@mail.nih.gov Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 SP - 124 EP - 130 VL - 7 KW - Receptors, Serotonin KW - 0 KW - Index Medicus KW - Phenotype KW - Polymorphism, Genetic KW - Alcoholism -- diagnosis KW - Humans KW - Receptors, Serotonin -- metabolism KW - Receptors, Serotonin -- genetics KW - Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68472206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=TheScientificWorldJournal&rft.atitle=Deconstruction+of+vulnerability+to+complex+diseases%3A+enhanced+effect+sizes+and+power+of+intermediate+phenotypes.&rft.au=Goldman%2C+David%3BDucci%2C+Francesca&rft.aulast=Goldman&rft.aufirst=David&rft.date=2007-11-02&rft.volume=7&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=TheScientificWorldJournal&rft.issn=1537-744X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. AN - 68463129; 17981125 AB - Communication between the endoplasmic reticulum (ER) and mitochondrion is important for bioenergetics and cellular survival. The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM). We found here that the ER protein sigma-1 receptor (Sig-1R), which is implicated in neuroprotection, carcinogenesis, and neuroplasticity, is a Ca(2+)-sensitive and ligand-operated receptor chaperone at MAM. Normally, Sig-1Rs form a complex at MAM with another chaperone, BiP. Upon ER Ca(2+) depletion or via ligand stimulation, Sig-1Rs dissociate from BiP, leading to a prolonged Ca(2+) signaling into mitochondria via IP3Rs. Sig-1Rs can translocate under chronic ER stress. Increasing Sig-1Rs in cells counteracts ER stress response, whereas decreasing them enhances apoptosis. These results reveal that the orchestrated ER chaperone machinery at MAM, by sensing ER Ca(2+) concentrations, regulates ER-mitochondrial interorganellar Ca(2+) signaling and cell survival. JF - Cell AU - Hayashi, Teruo AU - Su, Tsung-Ping AD - Cellular Pathobiology Unit, Plasticity and Development Section, Cellular Neurobiology Research Branch, Intramural Research Program, NIDA, NIH, DHHS, Baltimore, MD 21224, USA. thayashi@intra.nida.nih.gov Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 SP - 596 EP - 610 VL - 131 IS - 3 SN - 0092-8674, 0092-8674 KW - Heat-Shock Proteins KW - 0 KW - Inositol 1,4,5-Trisphosphate Receptors KW - Ligands KW - Molecular Chaperones KW - RNA, Small Interfering KW - Receptors, sigma KW - molecular chaperone GRP78 KW - sigma-1 receptor KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Heat-Shock Proteins -- metabolism KW - Protein Processing, Post-Translational -- drug effects KW - Animals KW - Thermodynamics KW - Cricetulus KW - Cytosol -- drug effects KW - Protein Transport -- drug effects KW - Up-Regulation -- genetics KW - Mice KW - RNA, Small Interfering -- metabolism KW - Inositol 1,4,5-Trisphosphate Receptors -- metabolism KW - Cell Survival -- drug effects KW - Protein Binding -- drug effects KW - CHO Cells KW - Adenosine Triphosphate -- pharmacology KW - Cricetinae KW - Endoplasmic Reticulum -- metabolism KW - Calcium Signaling -- drug effects KW - Molecular Chaperones -- metabolism KW - Receptors, sigma -- genetics KW - Receptors, sigma -- metabolism KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Intracellular Membranes -- metabolism KW - Endoplasmic Reticulum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68463129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Sigma-1+receptor+chaperones+at+the+ER-mitochondrion+interface+regulate+Ca%282%2B%29+signaling+and+cell+survival.&rft.au=Hayashi%2C+Teruo%3BSu%2C+Tsung-Ping&rft.aulast=Hayashi&rft.aufirst=Teruo&rft.date=2007-11-02&rft.volume=131&rft.issue=3&rft.spage=596&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A covalent inhibitor targeting an intermediate conformation of the fusogenic subunit of the HIV-1 envelope complex. AN - 68442493; 17726011 AB - Peptide inhibitors corresponding to sequences in the six helix bundle structure of the fusogenic portion (gp41) of the HIV envelope glycoprotein have been successfully implemented in preventing HIV entry. These peptides bind to regions in HIV gp41 transiently exposed during the fusion reaction. In an effort to improve upon these entry inhibitors, we have successfully designed and tested peptide analogs composed of chemical spacers and reactive moieties positioned strategically to facilitate covalent attachment. Using a temperature-arrested state prime wash in vitro assay we show evidence for the trapping of a pre-six helix bundle fusion intermediate by a covalent reaction with the specific anti-HIV-1 peptide. This is the first demonstration of the trapping of an intermediate conformation of a viral envelope glycoprotein during the fusion process that occurs in live cells. The permanent specific attachment of the covalent inhibitor is projected to improve the pharmacokinetics of administration in vivo and thereby improve the long-term sustainability of peptide entry inhibitor therapy and help to expand its applicability beyond salvage therapy. JF - The Journal of biological chemistry AU - Jacobs, Amy AU - Quraishi, Omar AU - Huang, Xicai AU - Bousquet-Gagnon, Nathalie AU - Nault, Geneviève AU - Francella, Nicholas AU - Alvord, W Gregory AU - Pham, Nga AU - Soucy, Chantal AU - Robitaille, Martin AU - Bridon, Dominique AU - Blumenthal, Robert AD - Center for Cancer Research Nanobiology Program, NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 SP - 32406 EP - 32413 VL - 282 IS - 44 SN - 0021-9258, 0021-9258 KW - Anti-HIV Agents KW - 0 KW - HIV Envelope Protein gp41 KW - Peptides KW - Index Medicus KW - Protein Folding KW - Inhibitory Concentration 50 KW - Models, Biological KW - Chromatography, High Pressure Liquid KW - Virus Internalization -- drug effects KW - Protein Conformation KW - HIV-1 -- metabolism KW - HIV-1 -- chemistry KW - Anti-HIV Agents -- metabolism KW - Anti-HIV Agents -- pharmacology KW - HIV Envelope Protein gp41 -- metabolism KW - Peptides -- metabolism KW - Peptides -- pharmacology KW - HIV-1 -- drug effects KW - HIV Envelope Protein gp41 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68442493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=A+covalent+inhibitor+targeting+an+intermediate+conformation+of+the+fusogenic+subunit+of+the+HIV-1+envelope+complex.&rft.au=Jacobs%2C+Amy%3BQuraishi%2C+Omar%3BHuang%2C+Xicai%3BBousquet-Gagnon%2C+Nathalie%3BNault%2C+Genevi%C3%A8ve%3BFrancella%2C+Nicholas%3BAlvord%2C+W+Gregory%3BPham%2C+Nga%3BSoucy%2C+Chantal%3BRobitaille%2C+Martin%3BBridon%2C+Dominique%3BBlumenthal%2C+Robert&rft.aulast=Jacobs&rft.aufirst=Amy&rft.date=2007-11-02&rft.volume=282&rft.issue=44&rft.spage=32406&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Implementing the Essential Nursing Competencies and Curricula Guidelines for Genetics and Genomics T2 - 39th Biennial Convention of the Honor Society of Nursing AN - 40745266; 4773560 JF - 39th Biennial Convention of the Honor Society of Nursing AU - Calzone, Kathleen A AU - Jenkins, Jean AU - Badzek, Laurie AU - Debisette, Annette AU - Feetham, Suzanne L AU - Hagan, Pamela AU - Hickey, Joanne AU - Kenner, Carole AU - Krugman, Mary AU - Lea, Dale AU - Lewis, Judith AU - Loud, Jennifer AU - Mayor, Rosario-May AU - McCloskey, Donna Jo AU - McGuinn, Kathleen AU - Messmer, Patricia R AU - Prows, Cynthia AU - Thomson, Elizabeth AU - Turner, Martha AU - Weaver, Michael AU - Williams, Janet K Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 KW - Genetics KW - Guidelines KW - Genomics KW - Nursing KW - Curricula KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40745266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.atitle=Implementing+the+Essential+Nursing+Competencies+and+Curricula+Guidelines+for+Genetics+and+Genomics&rft.au=Calzone%2C+Kathleen+A%3BJenkins%2C+Jean%3BBadzek%2C+Laurie%3BDebisette%2C+Annette%3BFeetham%2C+Suzanne+L%3BHagan%2C+Pamela%3BHickey%2C+Joanne%3BKenner%2C+Carole%3BKrugman%2C+Mary%3BLea%2C+Dale%3BLewis%2C+Judith%3BLoud%2C+Jennifer%3BMayor%2C+Rosario-May%3BMcCloskey%2C+Donna+Jo%3BMcGuinn%2C+Kathleen%3BMessmer%2C+Patricia+R%3BProws%2C+Cynthia%3BThomson%2C+Elizabeth%3BTurner%2C+Martha%3BWeaver%2C+Michael%3BWilliams%2C+Janet+K&rft.aulast=Calzone&rft.aufirst=Kathleen&rft.date=2007-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.issn=&rft_id=info:doi/ L2 - http://stti.confex.com/stti/bc39/techprogram/meeting_bc39.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Symptom Experience and Health-Related Quality of Life of Adult Survivors of Hematopoietic Stem Cell Transplantation (HSCT) with Chronic Graft-Versus-Host-Disease (cGVHD) T2 - 39th Biennial Convention of the Honor Society of Nursing AN - 40743678; 4773659 JF - 39th Biennial Convention of the Honor Society of Nursing AU - Fall-Dickson, Jane AU - Mitchell, Sandra AU - Marden, Susan AU - Ramsay, Edward AU - Imanguli, Matin AU - Guadagnini, Jean-Pierre AU - Odom, Jeanne AU - Atlam, Niveen AU - Pavletic, Steven Y1 - 2007/11/02/ PY - 2007 DA - 2007 Nov 02 KW - Quality of life KW - Stem cells KW - Stem cell transplantation KW - Transplantation KW - Symptoms KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40743678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.atitle=Oral+Symptom+Experience+and+Health-Related+Quality+of+Life+of+Adult+Survivors+of+Hematopoietic+Stem+Cell+Transplantation+%28HSCT%29+with+Chronic+Graft-Versus-Host-Disease+%28cGVHD%29&rft.au=Fall-Dickson%2C+Jane%3BMitchell%2C+Sandra%3BMarden%2C+Susan%3BRamsay%2C+Edward%3BImanguli%2C+Matin%3BGuadagnini%2C+Jean-Pierre%3BOdom%2C+Jeanne%3BAtlam%2C+Niveen%3BPavletic%2C+Steven&rft.aulast=Fall-Dickson&rft.aufirst=Jane&rft.date=2007-11-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Biennial+Convention+of+the+Honor+Society+of+Nursing&rft.issn=&rft_id=info:doi/ L2 - http://stti.confex.com/stti/bc39/techprogram/meeting_bc39.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Stochastic cooperativity in non-linear dynamics of genetic regulatory networks AN - 883027427; 15326486 AB - Two major approaches are known in the field of stochastic dynamics of genetic regulatory networks (GRN). The first one, referred here to as the Markov Process Paradigm (MPP), places the focus of attention on the fact that many biochemical constituents vitally important for the network functionality are present only in small quantities within the cell, and therefore the regulatory process is essentially discrete and prone to relatively big fluctuations. The Master Equation of Markov Processes is an appropriate tool for the description of this kind of stochasticity. The second approach, the Non-linear Dynamics Paradigm (NDP), treats the regulatory process as essentially continuous. A natural tool for the description of such processes are deterministic differential equations. According to NDP, stochasticity in such systems occurs due to possible bistability and oscillatory motion within the limit cycles. The goal of this paper is to outline a third scenario of stochasticity in the regulatory process. This scenario is only conceivable in high-dimensional, highly non-linear systems, and thus represents an adequate framework for conceptually modeling the GRN. We refer to this framework as the Stochastic Cooperativity Paradigm (SCP). In this approach, the focus of attention is placed on the fact that in systems with the size and link density of GRN ([not, vert, similar]25 000 and [not, vert, similar]100, respectively), the confluence of all the factors which are necessary for gene expression is a comparatively rare event, and only massive redundancy makes such events sufficiently frequent. An immediate consequence of this rareness is 'burstiness' in mRNA and protein concentrations, a well known effect in intracellular dynamics. We demonstrate that a high-dimensional non-linear system, despite the absence of explicit mechanisms for suppressing inherent instability, may nevertheless reside in a state of stationary pseudo-random fluctuations which for all practical purposes may be regarded as a stochastic process. This type of stochastic behavior is an inherent property of such systems and requires neither an external random force as in the Langevin approach, nor the discreteness of the process as in MPP, nor highly specialized conditions of bistability as in NDP, nor bifurcations with transition to chaos as in low-dimensional chaotic maps. JF - Mathematical Biosciences AU - Rosenfeld, Simon Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 121 EP - 142 PB - Elsevier B.V., Box 882 New York NY 10159 United States VL - 210 IS - 1 SN - 0025-5564, 0025-5564 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cooperativity KW - Stochasticity KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/883027427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mathematical+Biosciences&rft.atitle=Stochastic+cooperativity+in+non-linear+dynamics+of+genetic+regulatory+networks&rft.au=Rosenfeld%2C+Simon&rft.aulast=Rosenfeld&rft.aufirst=Simon&rft.date=2007-11-01&rft.volume=210&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Mathematical+Biosciences&rft.issn=00255564&rft_id=info:doi/10.1016%2Fj.mbs.2007.05.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2011-08-01 N1 - Last updated - 2014-03-24 N1 - SubjectsTermNotLitGenreText - Stochasticity DO - http://dx.doi.org/10.1016/j.mbs.2007.05.006 ER - TY - JOUR T1 - "[H]E is no more a person now but a whole climate of opinion" (Auden, 1940). AN - 85411820; pmid-18044672 JF - Cortex; a journal devoted to the study of the nervous system and behavior AU - Huey, Edward D AU - Zahn, Roland AU - Grafman, Jordan AD - Cognitive Neuroscience Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1440, USA. Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1097 EP - 8; discussion 1116-21 VL - 43 IS - 8 SN - 0010-9452, 0010-9452 KW - Index Medicus KW - National Library of Medicine KW - *Emotions: physiology KW - *Freudian Theory KW - Humans KW - Memory Disorders: psychology KW - Mental Processes: physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85411820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.atitle=%22%5BH%5DE+is+no+more+a+person+now+but+a+whole+climate+of+opinion%22+%28Auden%2C+1940%29.&rft.au=Huey%2C+Edward+D%3BZahn%2C+Roland%3BGrafman%2C+Jordan&rft.aulast=Huey&rft.aufirst=Edward&rft.date=2007-11-01&rft.volume=43&rft.issue=8&rft.spage=1097&rft.isbn=&rft.btitle=&rft.title=Cortex%3B+a+journal+devoted+to+the+study+of+the+nervous+system+and+behavior&rft.issn=00109452&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment On: Cortex. 2007 Nov;43(8):1083-90[18044668] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Regulation of the CLDN3 gene in ovarian cancer cells. AN - 70129911; 17986852 AB - The claudin (CLDN) genes encode a family of proteins involved in the formation and function of tight junctions. CLDN gene expression is frequently altered in several human cancers, and in particular, CLDN3 and CLDN4 are commonly overexpressed in ovarian cancer. However, the mechanisms leading to the deregulation of these genes in cancer remain unclear. In the present study, we have examined the CLDN3 promoter and have identified a minimal region containing an Sp1 site crucial for its activity. In addition, we find that the CLDN3 promoter is regulated through epigenetic processes. Cells that express high levels of CLDN3 exhibit low DNA methylation and high histone H3 acetylation of the critical CLDN3 promoter region, and the reverse is observed in cells that do not express this gene. CLDN3-negative cells can be induced to express CLDN3 through treatment with DNA methyltransferase or histone deacetylase inhibitors. Interestingly, in vitro binding experiments, as well as chip assays show that Sp1 binds the unmethylated promoter much more efficiently, providing a mechanism for CLDN3 silencing in non-expressing cells. Finally, siRNA-mediated knockdown of Sp1 led to a significant decrease of CLDN3 expression at both the mRNA and protein levels, demonstrating a crucial role for this transcription factor in the regulation of CLDN3. Our data provide a basis for CLDN3 expression in ovarian cancer cells, as well as a mechanism for the silencing of this promoter in tumors lacking expression of claudin-3. JF - Cancer biology & therapy AU - Honda, Hiroshi AU - Pazin, Michael J AU - D'Souza, Theresa AU - Ji, Hongxiu AU - Morin, Patrice J AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, Maryland, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1733 EP - 1742 VL - 6 IS - 11 KW - CLDN3 protein, human KW - 0 KW - CLDN4 protein, human KW - Claudin-3 KW - Claudin-4 KW - Hydroxamic Acids KW - Membrane Proteins KW - RNA, Messenger KW - SP3 protein, human KW - Sp1 Transcription Factor KW - Sp3 Transcription Factor KW - 148710-94-5 KW - trichostatin A KW - 3X2S926L3Z KW - decitabine KW - 776B62CQ27 KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Humans KW - RNA, Messenger -- analysis KW - Sp3 Transcription Factor -- metabolism KW - Cell Line, Tumor KW - Binding Sites KW - Mutagenesis, Site-Directed KW - Promoter Regions, Genetic KW - DNA Methylation KW - CpG Islands KW - Sp1 Transcription Factor -- metabolism KW - Hydroxamic Acids -- pharmacology KW - Female KW - Ovarian Neoplasms -- genetics KW - Ovarian Neoplasms -- pathology KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70129911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Regulation+of+the+CLDN3+gene+in+ovarian+cancer+cells.&rft.au=Honda%2C+Hiroshi%3BPazin%2C+Michael+J%3BD%27Souza%2C+Theresa%3BJi%2C+Hongxiu%3BMorin%2C+Patrice+J&rft.aulast=Honda&rft.aufirst=Hiroshi&rft.date=2007-11-01&rft.volume=6&rft.issue=11&rft.spage=1733&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=1555-8576&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-27 N1 - Date created - 2008-04-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - IL-6 enhances the nuclear translocation of DNA cytosine-5-methyltransferase 1 (DNMT1) via phosphorylation of the nuclear localization sequence by the AKT kinase. AN - 70057346; 18204201 AB - The epigenetic programming of genomic DNA is accomplished, in part, by several DNA cytosine-5-methyltransferases that act by covalently modifying cytosines with the addition of a methyl group. This covalent modification is maintained by the DNA cytosine-5-methyltransferase-1 enzyme (DNMT1), which is capable of acting in concert with other similar enzymes to silence important tumor suppressor genes. IL-6 is a multifunctional mediator of inflammation, acting through several major signaling cascades, including the phosphatidylinositol-3-kinase pathway (PI-3-K), which activates protein kinase B (AKT/PKB) downstream. Here, we show that the subcellular localization of DNMT1 can be altered by the addition of IL-6, increasing the rate of nuclear translocation of the enzyme from the cytosolic compartment. The mechanism of nuclear translocation of DNMT1 is greatly enhanced by phosphorylation of the DNMT1 nuclear localization signal (NLS) by PKB/AKT kinase. Mutagenic alteration of the two AKT target amino acids within the NLS results in a major loss of DNMT1 nuclear translocation, while the creation of a "phospho-mimic" amino acid (mutation to acidic residues) restores this compartmentation ability. These observations suggest an interesting hypothesis regarding how mediators of chronic inflammation may disturb the delicate balance of cellular compartmentalization of important proteins, and reveals a potential mechanism for the induction or enhancement of tumor growth via alteration of the components involved in the epigenetic programming of a cell. JF - Cancer genomics & proteomics AU - Hodge, David R AU - Cho, Edward AU - Copeland, Terry D AU - Guszczynski, Tad AU - Yang, Eric AU - Seth, Arun K AU - Farrar, William L AD - Laboratory of Cancer Prevention, Cancer Stem Cell Section, Center for Cancer Research, The National Cancer Institute at Frederick, Frederick, MD 21702, USA PY - 2007 SP - 387 EP - 398 VL - 4 IS - 6 SN - 1109-6535, 1109-6535 KW - Interleukin-6 KW - 0 KW - Karyopherins KW - Mutant Proteins KW - Nuclear Localization Signals KW - Phosphorus Radioisotopes KW - Recombinant Fusion Proteins KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Karyopherins -- metabolism KW - Protein Transport -- drug effects KW - Humans KW - Mutant Proteins -- metabolism KW - Amino Acid Sequence KW - Isotope Labeling KW - Phosphorylation -- drug effects KW - Sequence Analysis, Protein KW - Recombinant Fusion Proteins -- metabolism KW - Protein Binding -- drug effects KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Green Fluorescent Proteins -- metabolism KW - Cell Line KW - DNA (Cytosine-5-)-Methyltransferase -- chemistry KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Cell Nucleus -- enzymology KW - Interleukin-6 -- pharmacology KW - Cell Nucleus -- drug effects KW - Nuclear Localization Signals -- metabolism KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70057346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+genomics+%26+proteomics&rft.atitle=IL-6+enhances+the+nuclear+translocation+of+DNA+cytosine-5-methyltransferase+1+%28DNMT1%29+via+phosphorylation+of+the+nuclear+localization+sequence+by+the+AKT+kinase.&rft.au=Hodge%2C+David+R%3BCho%2C+Edward%3BCopeland%2C+Terry+D%3BGuszczynski%2C+Tad%3BYang%2C+Eric%3BSeth%2C+Arun+K%3BFarrar%2C+William+L&rft.aulast=Hodge&rft.aufirst=David&rft.date=2007-11-01&rft.volume=4&rft.issue=6&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Cancer+genomics+%26+proteomics&rft.issn=11096535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-06-27 N1 - Date created - 2008-01-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Telephone enhancement of long-term engagement (TELE) in continuing care for substance abuse treatment: a NIDA clinical trials network (CTN) study. AN - 69016420; 18058417 AB - The TELE study examined the feasibility and potential efficacy of phone calls to patients after discharge from short- term inpatient and residential substance abuse treatment programs to encourage compliance with continuing care plans. After review of their continuing care plans, 339 patients from four programs were randomized either to receive calls or to have no planned contact. Ninety-two percent of patients randomized to receive calls received at least one call. No difference was found between groups in self-reported attendance at one or more outpatient counseling sessions after discharge (p = .89). When program records of all participants were examined, those receiving calls had a greater likelihood of documented attendance (48%) than those not called (37%). Results were not statistically significant (p < .003) because of the Hochberg correction for multiple tests. While the phone calls were feasible, the lack of clear evidence of efficacy of the calls suggests the need for further investigation of the role of telephone intervention to encourage compliance and improve outcomes. JF - The American journal on addictions AU - Hubbard, Robert L AU - Leimberger, Jeffrey D AU - Haynes, Louise AU - Patkar, Ashwin A AU - Holter, John AU - Liepman, Michael R AU - Lucas, Kathi AU - Tyson, Breque AU - Day, Tammy AU - Thorpe, Elizabeth A AU - Faulkner, Briar AU - Hasson, Albert AU - National Institute on Drug Abuse AD - Duke University Medical Center, Durham, North Carolina, USA. Hubbard@ndri-nc.org ; National Institute on Drug Abuse PY - 2007 SP - 495 EP - 502 VL - 16 IS - 6 SN - 1055-0496, 1055-0496 KW - Index Medicus KW - Long-Term Care -- methods KW - Documentation KW - Humans KW - Counseling KW - Research Design KW - Aftercare KW - Ambulatory Care KW - Feasibility Studies KW - Patient Compliance KW - Length of Stay KW - Adult KW - Treatment Outcome KW - Follow-Up Studies KW - Hospitalization -- statistics & numerical data KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Continuity of Patient Care -- organization & administration KW - Telephone KW - Remote Consultation -- methods KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69016420?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Telephone+enhancement+of+long-term+engagement+%28TELE%29+in+continuing+care+for+substance+abuse+treatment%3A+a+NIDA+clinical+trials+network+%28CTN%29+study.&rft.au=Hubbard%2C+Robert+L%3BLeimberger%2C+Jeffrey+D%3BHaynes%2C+Louise%3BPatkar%2C+Ashwin+A%3BHolter%2C+John%3BLiepman%2C+Michael+R%3BLucas%2C+Kathi%3BTyson%2C+Breque%3BDay%2C+Tammy%3BThorpe%2C+Elizabeth+A%3BFaulkner%2C+Briar%3BHasson%2C+Albert%3BNational+Institute+on+Drug+Abuse&rft.aulast=Hubbard&rft.aufirst=Robert&rft.date=2007-11-01&rft.volume=16&rft.issue=6&rft.spage=495&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-31 N1 - Date created - 2007-12-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comparison of cervical and vaginal human papillomavirus. AN - 69009502; 17621246 AB - We wanted to compare detection of a broad spectrum of human papillomavirus (HPV) types detected in cellular specimens from the vagina and cervix, which could provide information about the potential of each anatomical site for harboring infection. Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells. We conducted follow-up study of 353 women who had participated in study of HPV and cervical neoplasia in Costa Rica. We collected paired cervical and vaginal specimens; vaginal specimens were collected from the fornix to minimize cervical contamination. Specimens were tested in a masked fashion for >40 HPV types using a MY09/MY11 PCR method and type-specific dot blot hybridization. The prevalence for any carcinogenic HPV type in vaginal and cervical specimens was similar (P = 0.3). However, the prevalence for any HPV type in vaginal specimens was greater than in cervical specimens (P = 0.0002), primarily due to a twofold increased vaginal prevalence of HPV types of the alpha3/alpha15 phylogenetic species (e.g., HPV61) (P <0.00005). Carcinogenic HPV types appeared to have a similar affinity for vaginal and cervical epithelium, but noncarcinogenic HPV types of the alpha3/alpha15 phylogenetic species may have a tropism for vaginal epithelium. JF - Sexually transmitted diseases AU - Castle, Philip E AU - Rodriguez, Ana C AU - Porras, Carolina AU - Herrero, Rolando AU - Schiffman, Mark AU - Gonzalez, Paula AU - Hildesheim, Allan AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 849 EP - 855 VL - 34 IS - 11 SN - 0148-5717, 0148-5717 KW - DNA, Viral KW - 0 KW - Index Medicus KW - Phylogeny KW - Humans KW - Aged KW - Polymerase Chain Reaction KW - Aged, 80 and over KW - DNA, Viral -- analysis KW - Adult KW - Cohort Studies KW - Vagina -- virology KW - Vaginal Smears KW - Cervix Uteri -- virology KW - Middle Aged KW - Costa Rica -- epidemiology KW - Female KW - Prevalence KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Uterine Cervical Neoplasms -- epidemiology KW - Papillomaviridae -- isolation & purification KW - Papillomavirus Infections -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Papillomaviridae -- genetics KW - Uterine Cervical Neoplasms -- virology KW - Cervical Intraepithelial Neoplasia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69009502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Sexually+transmitted+diseases&rft.atitle=A+comparison+of+cervical+and+vaginal+human+papillomavirus.&rft.au=Castle%2C+Philip+E%3BRodriguez%2C+Ana+C%3BPorras%2C+Carolina%3BHerrero%2C+Rolando%3BSchiffman%2C+Mark%3BGonzalez%2C+Paula%3BHildesheim%2C+Allan%3BBurk%2C+Robert+D&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2007-11-01&rft.volume=34&rft.issue=11&rft.spage=849&rft.isbn=&rft.btitle=&rft.title=Sexually+transmitted+diseases&rft.issn=01485717&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Infect Dis. 2005 Jun 1;191(11):1796-807 [15871111] Virology. 2005 Jun 20;337(1):76-84 [15914222] Cancer Res. 2006 Jan 15;66(2):1218-24 [16424061] J Natl Cancer Inst. 2006 Mar 1;98(5):303-15 [16507827] Vaccine. 2006 Aug 31;24 Suppl 3:S3/11-25 [16949997] Cancer Res. 2006 Oct 15;66(20):10112-9 [17047075] J Infect Dis. 2006 Dec 15;194(12):1702-5 [17109342] Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1):11-6 [17220326] J Clin Microbiol. 2007 Jun;45(6):1679-83 [17409209] Cancer Epidemiol Biomarkers Prev. 2001 Feb;10(2):95-100 [11219778] J Med Virol. 2002 Nov;68(3):417-23 [12226831] Am J Epidemiol. 2003 Feb 1;157(3):218-26 [12543621] Rev Panam Salud Publica. 2004 Feb;15(2):75-89 [15030652] Virology. 2004 Jun 20;324(1):17-27 [15183049] J Infect Dis. 2004 Aug 1;190(3):458-67 [15243917] Stat Med. 1989 May;8(5):551-61 [2657958] Lancet Oncol. 2005 Apr;6(4):204 [15830458] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis. AN - 69005417; 18049334 AB - The inhibitory receptor CTLA4 has a key role in peripheral tolerance of T cells for both normal and tumor-associated antigens. Murine experiments suggested that blockade of CTLA4 might have antitumor activity and a clinical experience with the blocking antibody ipilimumab in patients with metastatic melanoma did show durable tumor regressions in some patients. Therefore, a phase II study of ipilimumab was conducted in patients with metastatic renal cell cancer with a primary end point of response by Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Two sequential cohorts received either 3 mg/kg followed by 1 mg/kg or all doses at 3 mg/kg every 3 weeks (with no intention of comparing cohort response rates). Major toxicities were enteritis and endocrine deficiencies of presumed autoimmune origin. One of 21 patients receiving the lower dose had a partial response. Five of 40 patients at the higher dose had partial responses (95% confidence interval for cohort response rate 4% to 27%) and responses were seen in patients who had previously not responded to IL-2. Thirty-three percent of patients experienced a grade III or IV immune-mediated toxicity. There was a highly significant association between autoimmune events (AEs) and tumor regression (response rate=30% with AE, 0% without AE). CTLA4 blockade with ipilimumab induces cancer regression in some patients with metastatic clear cell renal cancer, even if they have not responded to other immunotherapies. These regressions are highly associated with other immune-mediated events of presumed autoimmune origin by mechanisms as yet undefined. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Yang, James C AU - Hughes, Marybeth AU - Kammula, Udai AU - Royal, Richard AU - Sherry, Richard M AU - Topalian, Suzanne L AU - Suri, Kimberly B AU - Levy, Catherine AU - Allen, Tamika AU - Mavroukakis, Sharon AU - Lowy, Israel AU - White, Donald E AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA. JamesYang@mail.nih.gov PY - 2007 SP - 825 EP - 830 VL - 30 IS - 8 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Antineoplastic Agents KW - ipilimumab KW - 6T8C155666 KW - Index Medicus KW - Bone Neoplasms -- immunology KW - Antineoplastic Agents -- administration & dosage KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- immunology KW - Humans KW - Lung Neoplasms -- drug therapy KW - Aged KW - Liver Neoplasms -- secondary KW - Adrenal Insufficiency -- chemically induced KW - Hypopituitarism -- chemically induced KW - Antineoplastic Agents -- adverse effects KW - Meningitis, Aseptic -- chemically induced KW - Liver Neoplasms -- drug therapy KW - Adult KW - Bone Neoplasms -- drug therapy KW - Treatment Outcome KW - Duodenitis -- chemically induced KW - Middle Aged KW - Colitis -- chemically induced KW - Antineoplastic Agents -- therapeutic use KW - Male KW - Bone Neoplasms -- secondary KW - Female KW - Liver Neoplasms -- immunology KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Kidney Neoplasms -- drug therapy KW - Enteritis -- chemically induced KW - Pituitary Diseases -- chemically induced KW - Carcinoma, Renal Cell -- drug therapy KW - Antibodies, Monoclonal -- adverse effects KW - Carcinoma, Renal Cell -- immunology KW - Antibodies, Monoclonal -- administration & dosage KW - Kidney Neoplasms -- immunology KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69005417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Ipilimumab+%28anti-CTLA4+antibody%29+causes+regression+of+metastatic+renal+cell+cancer+associated+with+enteritis+and+hypophysitis.&rft.au=Yang%2C+James+C%3BHughes%2C+Marybeth%3BKammula%2C+Udai%3BRoyal%2C+Richard%3BSherry%2C+Richard+M%3BTopalian%2C+Suzanne+L%3BSuri%2C+Kimberly+B%3BLevy%2C+Catherine%3BAllen%2C+Tamika%3BMavroukakis%2C+Sharon%3BLowy%2C+Israel%3BWhite%2C+Donald+E%3BRosenberg%2C+Steven+A&rft.aulast=Yang&rft.aufirst=James&rft.date=2007-11-01&rft.volume=30&rft.issue=8&rft.spage=825&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2000 Sep 14;343(11):750-8 [10984562] Science. 1996 Mar 22;271(5256):1734-6 [8596936] Annu Rev Immunol. 2001;19:565-94 [11244047] Nature. 2001 May 17;411(6835):380-4 [11357146] J Clin Oncol. 2001 Aug 1;19(15):3477-82 [11481353] Curr Opin Immunol. 2002 Dec;14(6):779-82 [12413529] Immunol Rev. 2003 Apr;192:143-60 [12670402] J Immunother Emphasis Tumor Immunol. 1996 Jan;19(1):81-4 [8859727] Ann Surg. 1998 Sep;228(3):307-19 [9742914] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] Annu Rev Immunol. 2005;23:515-48 [15771580] BJU Int. 2005 Aug;96(3):286-90 [16042715] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Immunother. 2005 Nov-Dec;28(6):593-8 [16224277] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] J Clin Oncol. 2005 Dec 10;23(35):8968-77 [16204013] J Clin Oncol. 2006 May 20;24(15):2283-9 [16710025] JAMA. 2006 Jun 7;295(21):2516-24 [16757724] Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4712-7 [12682289] Nature. 2003 May 29;423(6939):506-11 [12724780] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] Cell. 1992 Dec 24;71(7):1065-8 [1335362] Immunity. 1995 Nov;3(5):541-7 [7584144] Annu Rev Immunol. 2001;19:225-52 [11244036] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thyroid cancer incidence among people living in areas contaminated by radiation from the Chernobyl accident. AN - 68562541; 18049226 AB - As a result of the Chernobyl nuclear power plant accident, massive amounts of radioactive materials were released into the environment and large numbers of individuals living in Belarus, Russia, and Ukraine were exposed to radioactive iodines, primarily 131I. Iodine-131 concentrated in the thyroid gland of residents of the contaminated areas, with children and adolescents being particularly affected. In the decade after the accident, a substantial increase in thyroid cancer incidence was observed among exposed children in the three affected countries, and compelling evidence of an association between pediatric thyroid cancer incidence and radiation exposure to the thyroid gland accumulated. The data currently available suggest that both the magnitude and patterns of thyroid cancer risk are generally consistent with those reported following external exposure. Based on data from case-control studies, iodine deficiency appeared to enhance the risk of developing thyroid cancer following exposure from Chernobyl. Results from a recent large cohort study, however, did not support these findings. Data on adult exposure are limited and not entirely consistent. Similarly, information on thyroid cancer risks associated with in utero exposure is insufficient to draw conclusions. The lack of information on these two population groups indicates an important gap that needs to be filled. Twenty years after the accident, excess thyroid cancers are still occurring among persons exposed as children or adolescents, and, if external radiation can be used as a guide, we can expect an excess of radiation-associated thyroid cancers for several more decades. Since considerable uncertainties about the long-term health effects from Chernobyl remain, continued follow-up of the exposed populations should provide valuable information. JF - Health physics AU - Ron, Elaine AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA. eron@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 502 EP - 511 VL - 93 IS - 5 SN - 0017-9078, 0017-9078 KW - Iodine KW - 9679TC07X4 KW - Index Medicus KW - Ecology KW - Fetus -- radiation effects KW - Iodine -- deficiency KW - Sex Characteristics KW - Humans KW - Cohort Studies KW - Case-Control Studies KW - Incidence KW - Male KW - Female KW - Thyroid Neoplasms -- epidemiology KW - Chernobyl Nuclear Accident KW - Thyroid Neoplasms -- genetics KW - Neoplasms, Radiation-Induced -- etiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Thyroid Neoplasms -- etiology KW - Neoplasms, Radiation-Induced -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68562541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+physics&rft.atitle=Thyroid+cancer+incidence+among+people+living+in+areas+contaminated+by+radiation+from+the+Chernobyl+accident.&rft.au=Ron%2C+Elaine&rft.aulast=Ron&rft.aufirst=Elaine&rft.date=2007-11-01&rft.volume=93&rft.issue=5&rft.spage=502&rft.isbn=&rft.btitle=&rft.title=Health+physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-11-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Health Phys. 2009 Feb;96(2):186; author reply 186-7 [19131741] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complement deposits on ocular tissues adjacent to sites of inflammation. AN - 68522358; 18027167 AB - The complement system plays important roles in a variety of chronic ocular diseases such as age-related macular degeneration. Here we examined the deposition of complement components in mouse eyes damaged by various mechanisms. Mouse eyes were damaged by light or by three models of inflammation, i.e., local transgenic expression of cytokines, interleukin-1 or -7, or by induction of experimental autoimmune uveitis. Eye tissues obtained from each model were immunostained with antibodies against complement components C1q, C3, and C4. No complement deposition was seen in light damaged eyes, while in inflamed eyes we found complement deposition at sites of tissue damage and cellular infiltration. In addition to affected tissues, intense immunoreactivity against complement was unexpectedly observed in corneal tissues and lens capsule, despite lack of inflammation in these tissues. Our observations suggest that ocular tissues adjacent to inflammatory sites undergo changes that facilitate complement deposition. JF - Current eye research AU - Montalvo, Vanessa AU - Campos, Maria M AU - Chan, Chi-Chao AU - Wawrousek, Eric F AU - Bush, Ronald A AU - Lambris, John D AU - Gery, Igal AD - Laboratory of Immunology, National Eye Institute, NIH, Bethesda, Maryland 20892-1857, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 917 EP - 922 VL - 32 IS - 11 SN - 0271-3683, 0271-3683 KW - Complement C3 KW - 0 KW - Complement C4 KW - Eye Proteins KW - Interleukin-1 KW - Interleukin-7 KW - Retinol-Binding Proteins KW - interstitial retinol-binding protein KW - Complement C1q KW - 80295-33-6 KW - Index Medicus KW - Animals KW - Eye Proteins -- toxicity KW - Retinol-Binding Proteins -- toxicity KW - Radiation Injuries, Experimental -- metabolism KW - Interleukin-7 -- genetics KW - Cornea -- metabolism KW - Mice KW - Photoreceptor Cells, Vertebrate -- radiation effects KW - Mice, Inbred BALB C KW - Mice, Transgenic KW - Microscopy, Fluorescence KW - Retinal Diseases -- metabolism KW - Lens Capsule, Crystalline -- metabolism KW - Interleukin-1 -- genetics KW - Gene Expression -- physiology KW - Female KW - Male KW - Complement C4 -- metabolism KW - Autoimmune Diseases -- metabolism KW - Autoimmune Diseases -- chemically induced KW - Uveitis -- metabolism KW - Inflammation -- metabolism KW - Complement C1q -- metabolism KW - Complement C3 -- metabolism KW - Uveitis -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68522358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+eye+research&rft.atitle=Complement+deposits+on+ocular+tissues+adjacent+to+sites+of+inflammation.&rft.au=Montalvo%2C+Vanessa%3BCampos%2C+Maria+M%3BChan%2C+Chi-Chao%3BWawrousek%2C+Eric+F%3BBush%2C+Ronald+A%3BLambris%2C+John+D%3BGery%2C+Igal&rft.aulast=Montalvo&rft.aufirst=Vanessa&rft.date=2007-11-01&rft.volume=32&rft.issue=11&rft.spage=917&rft.isbn=&rft.btitle=&rft.title=Current+eye+research&rft.issn=02713683&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Curr Eye Res. 2008 Jan;33(1):109 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. AN - 68511298; 18006915 AB - GATA-binding protein 3 (GATA3) is a transcription factor and a putative tumor suppressor that is highly expressed in normal breast luminal epithelium and estrogen receptor alpha (ER)-positive breast tumors. We hypothesized that common genetic variation in GATA3 could influence breast carcinogenesis. Four tag single-nucleotide polymorphisms (SNP) in GATA3 and its 3' flanking gene FLJ4598 were genotyped in two case control studies in Norway and Poland (2,726 cases and 3,420 controls). Analyses of pooled data suggested a reduced risk of breast cancer associated with two intronic variants in GATA3 in linkage disequilibrium (rs3802604 in intron 3 and rs570613 in intron 4). Odds ratio (95% confidence interval) for rs570613 heterozygous and rare homozygous versus common homozygous were 0.85 (0.75-1.95) and 0.82 (0.62-0.96), respectively (P(trend)=0.004). Stronger associations were observed for subjects with ER-negative, than ER-positive, tumors (P(heterogeneity)=0.01 for rs3802604; P(heterogeneity)=0.09 for rs570613). Although no individual SNPs were associated with ER-positive tumors, two haplotypes (GGTC in 2% of controls and AATT in 7% of controls) showed significant and consistent associations with increased risk for these tumors when compared with the common haplotype (GATT in 46% of controls): 1.71 (1.27-2.32) and 1.26 (1.03-1.54), respectively. In summary, data from two independent study populations showed two intronic variants in GATA3 associated with overall decreases in breast cancer risk and suggested heterogeneity of these associations by ER status. These differential associations are consistent with markedly different levels of GATA3 protein by ER status. Additional epidemiologic studies are needed to clarify these intriguing relationships. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Garcia-Closas, Montserrat AU - Troester, Melissa A AU - Qi, Ying AU - Langerød, Anita AU - Yeager, Meredith AU - Lissowska, Jolanta AU - Brinton, Louise AU - Welch, Robert AU - Peplonska, Beata AU - Gerhard, Daniela S AU - Gram, Inger Torhild AU - Kristensen, Vessela AU - Børresen-Dale, Anne-Lise AU - Chanock, Stephen AU - Perou, Charles M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Room 7076, MSC 7234, Rockville, MD 20852-7234, USA. montse@nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 2269 EP - 2275 VL - 16 IS - 11 SN - 1055-9965, 1055-9965 KW - Estrogen Receptor alpha KW - 0 KW - GATA3 Transcription Factor KW - GATA3 protein, human KW - Receptors, Progesterone KW - Index Medicus KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Age Factors KW - Humans KW - Aged KW - Linkage Disequilibrium KW - Receptors, Progesterone -- genetics KW - Genotype KW - Haplotypes KW - Aged, 80 and over KW - Adult KW - Case-Control Studies KW - Middle Aged KW - Genetic Predisposition to Disease KW - Menopause KW - Female KW - Breast Neoplasms -- genetics KW - Estrogen Receptor alpha -- genetics KW - GATA3 Transcription Factor -- genetics KW - Breast Neoplasms -- metabolism KW - Estrogen Receptor alpha -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68511298?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Common+genetic+variation+in+GATA-binding+protein+3+and+differential+susceptibility+to+breast+cancer+by+estrogen+receptor+alpha+tumor+status.&rft.au=Garcia-Closas%2C+Montserrat%3BTroester%2C+Melissa+A%3BQi%2C+Ying%3BLanger%C3%B8d%2C+Anita%3BYeager%2C+Meredith%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise%3BWelch%2C+Robert%3BPeplonska%2C+Beata%3BGerhard%2C+Daniela+S%3BGram%2C+Inger+Torhild%3BKristensen%2C+Vessela%3BB%C3%B8rresen-Dale%2C+Anne-Lise%3BChanock%2C+Stephen%3BPerou%2C+Charles+M&rft.aulast=Garcia-Closas&rft.aufirst=Montserrat&rft.date=2007-11-01&rft.volume=16&rft.issue=11&rft.spage=2269&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-16 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lifestyle and reproductive factors associated with follicular phase length. AN - 68506273; 18001191 AB - Variability in menstrual cycle length, largely determined by variation in follicular phase length, is related to several health outcomes, yet the causes of this variability are incompletely understood. We sought to identify characteristics associated with follicular phase length. We used the North Carolina Early Pregnancy Study to describe factors correlated with timing of ovulation (follicular phase length). Women collected daily urine specimens and recorded vaginal bleeding. Specimens were assayed for estrone 3-glucuronide and pregnanediol 3-glucuronide, which in turn were used to estimate the day of ovulation. All other variables were assessed through interview. Associations with follicular phase length were evaluated using a multiple regression model. We determined follicular phase length for the first cycles of 201 women. Women with a history of miscarriage tended to have shorter follicular phases (2.2 days). Longer duration of oral contraceptive (OC) use and recent OC use (in the last 90 days) were both correlated with longer follicular phase. Occasional marijuana users (up to three times in the last 3 months) had a longer follicular phase than nonusers (3.5 days); the follicular phase in frequent users (more than three times) was almost 2 days longer than that of nonusers. The association between marijuana use and longer follicular phase is consistent with prior rhesus monkey research that shows ovulatory delay or inhibition. JF - Journal of women's health (2002) AU - Jukic, Anne Marie Zaura AU - Weinberg, Clarice R AU - Baird, Donna D AU - Wilcox, Allen J AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. jukica@niehs.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1340 EP - 1347 VL - 16 IS - 9 SN - 1540-9996, 1540-9996 KW - Biomarkers KW - 0 KW - pregnanediol-3 alpha-glucuronide KW - 1852-49-9 KW - Estrone KW - 2DI9HA706A KW - Pregnanediol KW - JR3JD1Y22C KW - Index Medicus KW - Luteal Phase -- urine KW - Women's Health KW - Humans KW - Adult KW - Surveys and Questionnaires KW - Menstrual Cycle -- urine KW - Estrone -- urine KW - Biomarkers -- urine KW - Pregnanediol -- analogs & derivatives KW - Female KW - Pregnanediol -- urine KW - Ovulation -- drug effects KW - Life Style KW - Marijuana Abuse -- urine KW - Menstruation Disturbances -- urine KW - Menstruation Disturbances -- etiology KW - Follicular Phase -- drug effects KW - Ovulation -- urine KW - Follicular Phase -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68506273?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+women%27s+health+%282002%29&rft.atitle=Lifestyle+and+reproductive+factors+associated+with+follicular+phase+length.&rft.au=Jukic%2C+Anne+Marie+Zaura%3BWeinberg%2C+Clarice+R%3BBaird%2C+Donna+D%3BWilcox%2C+Allen+J&rft.aulast=Jukic&rft.aufirst=Anne+Marie&rft.date=2007-11-01&rft.volume=16&rft.issue=9&rft.spage=1340&rft.isbn=&rft.btitle=&rft.title=Journal+of+women%27s+health+%282002%29&rft.issn=15409996&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-12 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Fertil Steril. 2006 Jun;85(6):1812-9 [16759929] Hum Reprod. 2006 May;21(5):1279-84 [16410331] J Clin Endocrinol Metab. 2006 May;91(5):1789-95 [16492698] J Obstet Gynecol Neonatal Nurs. 2006 May-Jun;35(3):376-84 [16700687] Contraception. 2006 Mar;73(3):235-43 [16472562] Hum Reprod. 2001 Dec;16(12):2501-7 [11726566] Gynecol Endocrinol. 2002 Aug;16(4):307-17 [12396560] Epidemiology. 2002 Nov;13(6):668-74 [12410008] Hum Reprod. 2003 Mar;18(3):495-501 [12615813] Hum Reprod. 2004 Feb;19(2):344-51 [14747178] J Clin Endocrinol Metab. 2004 Jun;89(6):2622-31 [15181033] Am J Epidemiol. 2004 Jul 15;160(2):131-40 [15234934] Int J Fertil. 1967 Jan-Mar;12(1 Pt 2):77-126 [5419031] J Clin Invest. 1975 Apr;55(4):699-706 [1120778] Am J Obstet Gynecol. 1976 Jan 1;124(1):88-91 [1244751] Int J Gynaecol Obstet. 1977;15(1):55-9 [923895] Br Med J. 1978 Feb 4;1(6108):265-7 [620301] Endoscopy. 1979 May;11(2):114-5 [446422] J Clin Endocrinol Metab. 1981 Jan;52(1):50-5 [6256405] Fertil Steril. 1981 May;35(5):532-4 [7227568] Science. 1983 Mar 25;219(4591):1453-5 [6298938] Fertil Steril. 1983 Dec;40(6):773-8 [6360719] Psychoneuroendocrinology. 1984;9(1):21-8 [6739662] Br J Obstet Gynaecol. 1984 Jul;91(7):681-4 [6743609] Psychopharmacology (Berl). 1984;84(2):178-87 [6438677] NIDA Res Monogr. 1984;55:24-31 [6443386] J Pharmacol Exp Ther. 1986 Jun;237(3):862-6 [3012072] Hum Reprod. 2000 Apr;15(4):752-5 [10739814] Eur J Epidemiol. 1999 Oct;15(9):809-14 [10608360] Acta Univ Palacki Olomuc Fac Med. 1981;101:95-101 [6242699] Eur J Obstet Gynecol Reprod Biol. 2007 Sep;134(1):67-72 [17303313] N Engl J Med. 1988 Jul 28;319(4):189-94 [3393170] Fertil Steril. 1990 Jan;53(1):21-7 [2295345] Epidemiology. 1990 Sep;1(5):382-5 [2078614] Stat Med. 1991 Feb;10(2):255-66 [2052803] Drug Alcohol Depend. 1991 Aug;28(2):121-8 [1935564] Br J Obstet Gynaecol. 1992 May;99(5):422-9 [1622917] J Clin Endocrinol Metab. 1994 Oct;79(4):1105-9 [7962282] Am J Epidemiol. 1994 Dec 15;140(12):1081-90 [7998590] Fertil Steril. 1995 Oct;64(4):689-92 [7672135] Epidemiology. 1995 Sep;6(5):547-50 [8562634] J Clin Endocrinol Metab. 1996 Mar;81(3):1038-45 [8772573] Am J Epidemiol. 1997 May 1;145(9):804-9 [9143210] Epidemiology. 1998 Mar;9(2):193-8 [9504290] Am J Epidemiol. 1998 Jun 1;147(11):1071-80 [9620051] Obstet Gynecol. 1999 Jan;93(1):59-65 [9916957] Am J Epidemiol. 1999 Mar 15;149(6):550-7 [10084244] Gynecol Endocrinol. 2005 Feb;20(2):74-9 [15823825] Epidemiology. 2006 Jan;17(1):52-60 [16357595] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. AN - 68501362; 17998440 AB - Imaging studies have provided new insights on the role of dopamine (DA) in drug abuse and addiction in the human brain. These studies have shown that the reinforcing effects of drugs of abuse in human beings are contingent not just on DA increases per se in the striatum (including the nucleus accumbens) but on the rate of DA increases. The faster the increases, the more intense the reinforcing effects. They have also shown that elevated levels of DA in the dorsal striatum are involved in the motivation to procure the drug when the addicted subject is exposed to stimuli associated with the drug (conditioned stimuli). In contrast, long-term drug use seems to be associated with decreased DA function, as evidenced by reductions in D2 DA receptors and DA release in the striatum in addicted subjects. Moreover, the reductions in D2 DA receptors in the striatum are associated with reduced activity of the orbitofrontal cortex (region involved with salience attribution and motivation and with compulsive behaviors) and of the cingulate gyrus (region involved with inhibitory control and impulsivity), which implicates deregulation of frontal regions by DA in the loss of control and compulsive drug intake that characterizes addiction. Because DA cells fire in response to salient stimuli and facilitate conditioned learning, their activation by drugs will be experienced as highly salient, driving the motivation to take the drug and further strengthening conditioned learning and producing automatic behaviors (compulsions and habits). JF - Archives of neurology AU - Volkow, Nora D AU - Fowler, Joanna S AU - Wang, Gene-Jack AU - Swanson, James M AU - Telang, Frank AD - National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274-MSC 9581, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1575 EP - 1579 VL - 64 IS - 11 SN - 0003-9942, 0003-9942 KW - Receptors, Dopamine D2 KW - 0 KW - Dopamine KW - VTD58H1Z2X KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Receptors, Dopamine D2 -- physiology KW - Receptors, Dopamine D2 -- metabolism KW - Diagnostic Imaging -- methods KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- pathology KW - Dopamine -- metabolism KW - Brain -- metabolism KW - Substance-Related Disorders -- metabolism KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68501362?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+neurology&rft.atitle=Dopamine+in+drug+abuse+and+addiction%3A+results+of+imaging+studies+and+treatment+implications.&rft.au=Volkow%2C+Nora+D%3BFowler%2C+Joanna+S%3BWang%2C+Gene-Jack%3BSwanson%2C+James+M%3BTelang%2C+Frank&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2007-11-01&rft.volume=64&rft.issue=11&rft.spage=1575&rft.isbn=&rft.btitle=&rft.title=Archives+of+neurology&rft.issn=00039942&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-24 N1 - Date created - 2007-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the endocannabinoid system: therapeutic potential against cocaine dependence. AN - 68479251; 17945506 AB - Dependence on cocaine is still a main unresolved medical and social concern, and in spite of research efforts, no pharmacological therapy against cocaine dependence is yet available. Recent studies have shown that the endocannabinoid system participates in specific stages and aspects of drug dependence in general, and some of this evidence suggests an involvement of the cannabinoid system in cocaine effects. For example, cocaine administration has been shown to alter brain endocannabinoid levels, and the endocannabinoid system has been involved in long-term modifications of brain processes that might play a role in neuro/behavioral effects of psychostimulant drugs like cocaine. Human studies show that marijuana dependence is frequently associated with cocaine dependence, and that the cannabinoid receptor CNR1 gene polymorphism might be related to cocaine addiction. This article will review the main papers in the field showing how a modulation of different components of the cannabinoid system might interact with some of the neurobiological/behavioral effects of cocaine related to its reinforcing effects, evaluated in preclinical models or in clinical settings. The goal of this review will be to provide insights into the complex picture of cocaine abuse and addiction, and to extrapolate from such endocannabinoid-cocaine interactions useful information to test the therapeutic potential of cannabinoid ligands and endocannabinoid-level enhancers against cocaine dependence for future preclinical/clinical trials. JF - Pharmacological research AU - Tanda, Gianluigi AD - Psychobiology Section, Medications Discovery Research Branch, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. gtanda@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 406 EP - 417 VL - 56 IS - 5 SN - 1043-6618, 1043-6618 KW - Cannabinoid Receptor Modulators KW - 0 KW - Central Nervous System Agents KW - Endocannabinoids KW - Index Medicus KW - Animals KW - Humans KW - Cannabinoid Receptor Modulators -- metabolism KW - Cocaine-Related Disorders -- drug therapy KW - Central Nervous System Agents -- therapeutic use KW - Cocaine-Related Disorders -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68479251?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacological+research&rft.atitle=Modulation+of+the+endocannabinoid+system%3A+therapeutic+potential+against+cocaine+dependence.&rft.au=Tanda%2C+Gianluigi&rft.aulast=Tanda&rft.aufirst=Gianluigi&rft.date=2007-11-01&rft.volume=56&rft.issue=5&rft.spage=406&rft.isbn=&rft.btitle=&rft.title=Pharmacological+research&rft.issn=10436618&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neurosci Biobehav Rev. 2004 Jan;27(8):813-20 [15019430] Mol Psychiatry. 2004 Oct;9(10):916-31 [15289816] Int J Addict. 1972;7(1):27-55 [5043838] J Pharmacol Exp Ther. 1975 Jul;194(1):74-81 [168349] Mol Pharmacol. 1976 May;12(3):345-52 [934055] Eur J Pharmacol. 1976 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AN - 68476793; 17915219 AB - Mutations in the CARD15 gene encoding NOD2 are susceptibility factors in Crohn's disease. We explored the mechanism of this susceptibility using mice that over express NOD2. Cellular and molecular responses of mice bearing an NOD2 transgene or administered plasmids that express wild-type and mutated NOD2 constructs were examined. In initial studies, we showed that splenocytes from NOD2 transgenic mice as compared with littermate controls exhibit decreased interleukin (IL)-12p70 responses to peptidoglycan (PGN), a TLR2 ligand that contains muramyl dipeptide, but not other TLR ligands; in contrast, IL-12 responses to PAM(3)CSK(4), a TLR2 ligand that does not contain muramyl dipeptide, were normal. Similarly, transgenic mice as compared with controls exhibited greatly decreased IL-12p40 responses to intraperitoneal administration of PGN but not to lipopolysaccharide. In further studies, we showed using electrophoretic mobility shift assay that PGN-stimulated cells from transgenic mice exhibited decreased activation of nuclear factor kappaB. Finally, in a series of studies on the effect of the NOD2 on susceptibility to induced colitis, we found that (1) transgenic mice were highly resistant to induction of PGN colitis and partially resistant to induction of trinitrobenzene sulfonic acid (TNBS) colitis and (2) mice administered a plasmid expressing a wild-type NOD2 gene were completely resistant to TNBS colitis whereas mice administered a plasmid expressing an NOD2 gene with the Crohn's disease frameshift mutation were only slightly resistant to TNBS colitis. These data offer new evidence that NOD2 mutations contribute to inflammatory bowel disease by causing excessive TLR2 cytokine responses. JF - Gastroenterology AU - Yang, Zhiqiong AU - Fuss, Ivan J AU - Watanabe, Tomohiro AU - Asano, Naoki AU - Davey, Michael P AU - Rosenbaum, James T AU - Strober, Warren AU - Kitani, Atsushi AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1510 EP - 1521 VL - 133 IS - 5 KW - Adjuvants, Immunologic KW - 0 KW - Card15 protein, mouse KW - NF-kappa B KW - Nod2 Signaling Adaptor Protein KW - Peptidoglycan KW - Tlr2 protein, mouse KW - Toll-Like Receptor 2 KW - Interleukin-12 KW - 187348-17-0 KW - Acetylmuramyl-Alanyl-Isoglutamine KW - 53678-77-6 KW - Trinitrobenzenesulfonic Acid KW - 8T3HQG2ZC4 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Immunity, Innate -- drug effects KW - Spleen -- metabolism KW - Spleen -- cytology KW - Plasmids -- genetics KW - Mice KW - Mice, Transgenic KW - Frameshift Mutation -- genetics KW - Interleukin-12 -- metabolism KW - Cells, Cultured KW - Monocytes -- cytology KW - Monocytes -- metabolism KW - Mice, Inbred C57BL KW - NF-kappa B -- metabolism KW - Colitis -- immunology KW - Acetylmuramyl-Alanyl-Isoglutamine -- pharmacology KW - Toll-Like Receptor 2 -- metabolism KW - Toll-Like Receptor 2 -- genetics KW - Colitis -- chemically induced KW - Adjuvants, Immunologic -- pharmacology KW - Nod2 Signaling Adaptor Protein -- genetics KW - Down-Regulation -- drug effects KW - Colitis -- genetics KW - Nod2 Signaling Adaptor Protein -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68476793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gastroenterology&rft.atitle=NOD2+transgenic+mice+exhibit+enhanced+MDP-mediated+down-regulation+of+TLR2+responses+and+resistance+to+colitis+induction.&rft.au=Yang%2C+Zhiqiong%3BFuss%2C+Ivan+J%3BWatanabe%2C+Tomohiro%3BAsano%2C+Naoki%3BDavey%2C+Michael+P%3BRosenbaum%2C+James+T%3BStrober%2C+Warren%3BKitani%2C+Atsushi&rft.aulast=Yang&rft.aufirst=Zhiqiong&rft.date=2007-11-01&rft.volume=133&rft.issue=5&rft.spage=1510&rft.isbn=&rft.btitle=&rft.title=Gastroenterology&rft.issn=1528-0012&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-19 N1 - Date created - 2007-11-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18129-34 [16330776] Gastroenterology. 1993 Mar;104(3):759-71 [7680014] Immunity. 2006 Sep;25(3):473-85 [16949315] J Clin Invest. 2005 Nov;115(11):3057-71 [16239967] Gut. 2005 Nov;54(11):1515-8 [16227353] Lancet. 2005 May 21-27;365(9473):1794-6 [15910952] J Immunol. 2005 May 15;174(10):6518-23 [15879155] Cell Microbiol. 2005 Jan;7(1):53-61 [15617523] Curr Biol. 2004 Dec 29;14(24):2217-27 [15620648] Science. 2005 Feb 4;307(5710):731-4 [15692051] J Immunol Methods. 1993 Dec 3;166(2):287-91 [7507147] Nat Rev Immunol. 2006 Jan;6(1):9-20 [16493424] J Biol Chem. 2001 Feb 16;276(7):4812-8 [11087742] Nature. 2001 May 31;411(6837):599-603 [11385576] Nature. 2001 May 31;411(6837):603-6 [11385577] Annu Rev Immunol. 2002;20:495-549 [11861611] J Clin Invest. 2002 Sep;110(6):843-50 [12235116] J Biol Chem. 2003 Feb 21;278(8):5509-12 [12514169] Nat Rev Immunol. 2003 May;3(5):371-82 [12766759] Inflamm Res. 2003 Jun;52(6):272-6 [12835899] Nat Rev Immunol. 2003 Jul;3(7):521-33 [12876555] J Biol Chem. 2003 Oct 24;278(43):41702-8 [12871942] Gut. 2003 Nov;52(11):1591-7 [14570728] Nat Immunol. 2004 Aug;5(8):800-8 [15220916] Infect Immun. 1988 Aug;56(8):2101-8 [3397186] Comment In: Gastroenterology. 2007 Nov;133(5):1721-3 [17983814] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Myrrh: medical marvel or myth of the Magi? AN - 68464546; 17978635 AB - Since antiquity, the genus Commiphora is composed of more than 200 species, and has been exploited as a natural drug to treat pain, skin infections, inflammatory conditions, diarrhea, and periodontal diseases. In more recent history, products derived from Commiphora myrrha and various other species of Commiphora are becoming recognized to possess significant antiseptic, anesthetic, and antitumor properties. Traditional practice and evidence-based research have supported that these properties are directly attributable to terpenoids (especially furanosesquiterpenes), the active compounds present in myrrh essential oil. More recently, current studies have focused on applying clinical trial methodologies to validate its use as an antineoplastic, an antiparasitic agent, and as an adjunct in healing wounds. JF - Holistic nursing practice AU - Nomicos, Effie Y H AD - National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland, USA. enomicos@niaid.nih.gov PY - 2007 SP - 308 EP - 323 VL - 21 IS - 6 SN - 0887-9311, 0887-9311 KW - Anesthetics KW - 0 KW - Anti-Infective Agents, Local KW - Antineoplastic Agents KW - Oils, Volatile KW - Plant Oils KW - Resins, Plant KW - Sesquiterpenes KW - Terpenes KW - myrrh oil KW - H74221J5J4 KW - Nursing KW - Anti-Infective Agents, Local -- therapeutic use KW - Resins, Plant -- therapeutic use KW - Evidence-Based Medicine KW - Drug Interactions KW - Anesthetics -- therapeutic use KW - Humans KW - Resins, Plant -- pharmacology KW - Sesquiterpenes -- therapeutic use KW - Marketing of Health Services KW - Resins, Plant -- chemistry KW - Antineoplastic Agents -- therapeutic use KW - Phytotherapy -- methods KW - Plant Oils -- therapeutic use KW - Oils, Volatile -- pharmacology KW - Terpenes -- chemistry KW - Plant Oils -- pharmacology KW - Plant Oils -- chemistry KW - Oils, Volatile -- chemistry KW - Terpenes -- pharmacology KW - Phytotherapy -- trends KW - Oils, Volatile -- therapeutic use KW - Commiphora -- chemistry KW - Terpenes -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68464546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Holistic+nursing+practice&rft.atitle=Myrrh%3A+medical+marvel+or+myth+of+the+Magi%3F&rft.au=Nomicos%2C+Effie+Y+H&rft.aulast=Nomicos&rft.aufirst=Effie+Y&rft.date=2007-11-01&rft.volume=21&rft.issue=6&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Holistic+nursing+practice&rft.issn=08879311&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-18 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Affect regulation, stimulant use, and viral load among HIV-positive persons on anti-retroviral therapy. AN - 68454675; 17942835 AB - A substantial minority of HIV-positive individuals have comorbid affective or substance use disorders, which can interfere with effective medical management. The present study examined the associations among affect regulation, substance use, non-adherence to anti-retroviral therapy (ART), and immune status in a diverse sample of HIV-positive persons. A total of 858 HIV-positive participants self-reporting risk of transmitting HIV were enrolled in a randomized behavioral prevention trial and provided baseline blood samples to measure T-helper (CD4+) counts and HIV viral load. Among individuals on ART, regular stimulant users had a five-fold (0.70 log10) higher HIV viral load than those who denied regular stimulant use. The association between regular stimulant use and elevated HIV viral load remained after accounting for demographics, differences in CD4+ counts, and polysubstance use. In the final model, 1 unit increase in affect regulation (decreased severity of depressive symptoms as well as enhanced positive states of mind) was associated with a 23% decrease in the likelihood of reporting regular stimulant use and 15% decrease in the likelihood of being classified as nonadherent to ART. Regular stimulant users, in turn, were more than twice as likely to be nonadherent to ART. Even after accounting for the effects of nonadherence and CD4+ counts, regular stimulant use was independently associated with 50% higher HIV viral load. Increased mental health treatment as well as more intensive referrals to substance abuse treatment or 12-step self-help groups may be crucial to assist stimulant users with more effectively managing treatment for HIV/AIDS. JF - Psychosomatic medicine AU - Carrico, Adam W AU - Johnson, Mallory O AU - Moskowitz, Judith T AU - Neilands, Torsten B AU - Morin, Stephen F AU - Charlebois, Edwin D AU - Steward, Wayne T AU - Remien, Robert H AU - Wong, F Lennie AU - Rotheram-Borus, Mary Jane AU - Lightfoot, Marguerita A AU - Chesney, Margaret A AU - NIMH Healthy Living Project Team AD - Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143-0848, USA. adam.carrico@ucsf.edu ; NIMH Healthy Living Project Team Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 785 EP - 792 VL - 69 IS - 8 KW - Anti-Retroviral Agents KW - 0 KW - Central Nervous System Stimulants KW - Index Medicus KW - Viral Load KW - Patient Compliance KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Central Nervous System Stimulants -- administration & dosage KW - CD4 Lymphocyte Count KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - HIV Infections -- virology KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Affect KW - HIV Infections -- psychology KW - Anti-Retroviral Agents -- therapeutic use KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68454675?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychosomatic+medicine&rft.atitle=Affect+regulation%2C+stimulant+use%2C+and+viral+load+among+HIV-positive+persons+on+anti-retroviral+therapy.&rft.au=Carrico%2C+Adam+W%3BJohnson%2C+Mallory+O%3BMoskowitz%2C+Judith+T%3BNeilands%2C+Torsten+B%3BMorin%2C+Stephen+F%3BCharlebois%2C+Edwin+D%3BSteward%2C+Wayne+T%3BRemien%2C+Robert+H%3BWong%2C+F+Lennie%3BRotheram-Borus%2C+Mary+Jane%3BLightfoot%2C+Marguerita+A%3BChesney%2C+Margaret+A%3BNIMH+Healthy+Living+Project+Team&rft.aulast=Carrico&rft.aufirst=Adam&rft.date=2007-11-01&rft.volume=69&rft.issue=8&rft.spage=785&rft.isbn=&rft.btitle=&rft.title=Psychosomatic+medicine&rft.issn=1534-7796&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-10 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Randomized clinical trial design for assessing noninferiority when superiority is expected. AN - 68453754; 17971602 AB - The randomized clinical trial (RCT) is the gold standard for definitive evaluation of new therapies. RCTs designed to show that the therapeutic efficacy of a new therapy is not unacceptably inferior to that of standard therapy are called noninferiority trials. Traditionally, noninferiority trials have required very large sample sizes. Sometimes, a new treatment regimen with a favorable toxicity and/or tolerability profile is also expected to have some modest improvement in efficacy. In such specialized settings we describe a hybrid trial-design approach that requires a dramatically smaller sample size than that of a standard noninferiority design. This hybrid design can naturally incorporate a formal test of superiority as well as noninferiority. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Freidlin, Boris AU - Korn, Edward L AU - George, Stephen L AU - Gray, Robert AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD 20892, USA. freidlinb@ctep.nci.nih.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 5019 EP - 5023 VL - 25 IS - 31 KW - Index Medicus KW - Humans KW - Sample Size KW - Proportional Hazards Models KW - Randomized Controlled Trials as Topic KW - Research Design UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68453754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Randomized+clinical+trial+design+for+assessing+noninferiority+when+superiority+is+expected.&rft.au=Freidlin%2C+Boris%3BKorn%2C+Edward+L%3BGeorge%2C+Stephen+L%3BGray%2C+Robert&rft.aulast=Freidlin&rft.aufirst=Boris&rft.date=2007-11-01&rft.volume=25&rft.issue=31&rft.spage=5019&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-26 N1 - Date created - 2007-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Protective effect of diphenylmethyl selenocyanate against CCl4-induced hepatic injury. AN - 68450579; 17351915 AB - Organoselenocyanates represent an important class of chemopreventive agent, which possess antioxidative, antimutagenic as well as cancer chemopreventive properties. The present study is an attempt to evaluate the protective effect of diphenylmethyl selenocyanate -- a synthetic organoselenocyanate against carbon tetrachloride (CCl(4))-induced hepatic damage in Swiss albino mice in vivo. Mice were pretreated with the Se-compound orally in a duration dependent manner (7 and 15 days) to observe its protective action against an acute toxic dose (24 h) of CCl(4) (single injection at a dose of 20 microl and 50 microl kg(-1) b.w.) that induced hepatic necrosis and caused DNA damage (strand breaks) in the hepatocytes. This study revealed that pretreatment with the Se-compound reduced the extent of massive hepatic necrosis in a duration dependent manner, but it had no modulatory effect on hepatocellular apoptosis caused by acute toxic doses of CCl(4). It was also found that the Se-compound could significantly (P < 0.01) prevent the CCl(4)-induced elevation of DNA damage in hepatocytes measured by comet assay in a duration dependent manner. So these findings will further strengthen the view that organoselenocyanate is an effective chemopreventive agent against acute hepatic damage, caused by halogenated alkanes such as CCl(4). JF - Journal of applied toxicology : JAT AU - Das, Rajat Kumar AU - Hossain, Sk Ugir AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India. PY - 2007 SP - 527 EP - 537 VL - 27 IS - 6 SN - 0260-437X, 0260-437X KW - Antioxidants KW - 0 KW - Organoselenium Compounds KW - diphenylmethyl selenocyanate KW - Carbon Tetrachloride KW - CL2T97X0V0 KW - Index Medicus KW - Administration, Oral KW - Comet Assay KW - Animals KW - Apoptosis -- drug effects KW - Oxidative Stress -- drug effects KW - Disease Models, Animal KW - Mice KW - Time Factors KW - Female KW - Organoselenium Compounds -- administration & dosage KW - Organoselenium Compounds -- pharmacology KW - Liver -- pathology KW - Organoselenium Compounds -- therapeutic use KW - Massive Hepatic Necrosis -- metabolism KW - Antioxidants -- pharmacology KW - Liver -- drug effects KW - Antioxidants -- therapeutic use KW - Massive Hepatic Necrosis -- chemically induced KW - Massive Hepatic Necrosis -- prevention & control KW - Liver -- metabolism KW - Massive Hepatic Necrosis -- pathology KW - DNA Damage -- drug effects KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68450579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+applied+toxicology+%3A+JAT&rft.atitle=Protective+effect+of+diphenylmethyl+selenocyanate+against+CCl4-induced+hepatic+injury.&rft.au=Das%2C+Rajat+Kumar%3BHossain%2C+Sk+Ugir%3BBhattacharya%2C+Sudin&rft.aulast=Das&rft.aufirst=Rajat&rft.date=2007-11-01&rft.volume=27&rft.issue=6&rft.spage=527&rft.isbn=&rft.btitle=&rft.title=Journal+of+applied+toxicology+%3A+JAT&rft.issn=0260437X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tarantula toxins interact with voltage sensors within lipid membranes. AN - 68445189; 17938232 AB - Voltage-activated ion channels are essential for electrical signaling, yet the mechanism of voltage sensing remains under intense investigation. The voltage-sensor paddle is a crucial structural motif in voltage-activated potassium (K(v)) channels that has been proposed to move at the protein-lipid interface in response to changes in membrane voltage. Here we explore whether tarantula toxins like hanatoxin and SGTx1 inhibit K(v) channels by interacting with paddle motifs within the membrane. We find that these toxins can partition into membranes under physiologically relevant conditions, but that the toxin-membrane interaction is not sufficient to inhibit K(v) channels. From mutagenesis studies we identify regions of the toxin involved in binding to the paddle motif, and those important for interacting with membranes. Modification of membranes with sphingomyelinase D dramatically alters the stability of the toxin-channel complex, suggesting that tarantula toxins interact with paddle motifs within the membrane and that they are sensitive detectors of lipid-channel interactions. JF - The Journal of general physiology AU - Milescu, Mirela AU - Vobecky, Jan AU - Roh, Soung H AU - Kim, Sung H AU - Jung, Hoi J AU - Kim, Jae Il AU - Swartz, Kenton J AD - Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. milescum@ninds.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 497 EP - 511 VL - 130 IS - 5 SN - 0022-1295, 0022-1295 KW - Lipid Bilayers KW - 0 KW - Lipids KW - Potassium Channels KW - Proteins KW - Spider Venoms KW - Phosphoric Diester Hydrolases KW - EC 3.1.4.- KW - sphingomyelin phosphodiesterase D KW - EC 3.1.4.41 KW - Index Medicus KW - Animals KW - Xenopus laevis -- metabolism KW - Models, Molecular KW - Phosphoric Diester Hydrolases -- chemistry KW - Magnetic Resonance Spectroscopy KW - Potassium Channels -- chemistry KW - Proteins -- chemistry KW - Spectrometry, Fluorescence -- methods KW - Amino Acid Motifs KW - Oocytes -- metabolism KW - Electrophysiology -- methods KW - Lipids -- chemistry KW - Spiders KW - Cell Membrane -- metabolism KW - Molecular Conformation KW - Lipid Bilayers -- metabolism KW - Spider Venoms -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68445189?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+general+physiology&rft.atitle=Tarantula+toxins+interact+with+voltage+sensors+within+lipid+membranes.&rft.au=Milescu%2C+Mirela%3BVobecky%2C+Jan%3BRoh%2C+Soung+H%3BKim%2C+Sung+H%3BJung%2C+Hoi+J%3BKim%2C+Jae+Il%3BSwartz%2C+Kenton+J&rft.aulast=Milescu&rft.aufirst=Mirela&rft.date=2007-11-01&rft.volume=130&rft.issue=5&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+general+physiology&rft.issn=00221295&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-25 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8585-9 [9671721] Biophys J. 2007 Aug 15;93(4):L20-2 [17573432] Methods Enzymol. 1999;294:208-24 [9916229] J Mol Biol. 2000 Mar 31;297(3):771-80 [10731427] J Gen Physiol. 2000 Jun;115(6):673-84 [10828242] J Lipid Res. 2000 Sep;41(9):1448-54 [10974052] Anal Biochem. 2000 Oct 15;285(2):235-45 [11017708] J Gen Physiol. 2000 Nov;116(5):637-44 [11055992] Biochim Biophys Acta. 2000 Nov 10;1469(3):159-95 [11063882] J Gen Physiol. 2001 Mar;117(3):205-18 [11222625] Biophys J. 2001 Sep;81(3):1699-709 [11509382] Biophys J. 2001 Sep;81(3):1710-34 [11509383] Nature. 2001 Oct 25;413(6858):809-13 [11677598] Nature. 2003 Mar 13;422(6928):180-5 [12629550] Nature. 2003 May 1;423(6935):33-41 [12721618] Nature. 2003 May 1;423(6935):42-8 [12721619] Neuron. 2003 Oct 30;40(3):527-36 [14642277] Biochemistry. 2004 Feb 3;43(4):890-7 [14744131] Cell Calcium. 2004 May;35(5):427-31 [15003852] J Gen Physiol. 2004 Apr;123(4):455-67 [15051809] Trends Neurosci. 2004 Jun;27(6):303-7 [15165733] Nature. 2004 Jul 8;430(6996):232-5 [15241419] Nature. 2004 Jul 8;430(6996):235-40 [15241420] Science. 2004 Oct 15;306(5695):491-5 [15486302] Biochemistry. 1988 Aug 23;27(17):6197-202 [3064805] Anal Biochem. 1989 Nov 1;182(2):319-26 [2610349] Biochemistry. 1990 Jan 9;29(1):52-8 [2322549] Nature. 1993 Mar 11;362(6416):127-33 [7680768] Biochemistry. 1994 Jun 7;33(22):6834-9 [8204618] J Gen Physiol. 1994 Oct;104(4):645-73 [7530766] Neuron. 1995 Jul;15(1):5-10 [7542463] Neuron. 1995 Oct;15(4):941-9 [7576642] J Biol Chem. 1996 Jul 5;271(27):15950-62 [8663157] Neuron. 1997 Apr;18(4):665-73 [9136774] Neuron. 1997 Apr;18(4):675-82 [9136775] J Neurosci Res. 1997 Aug 1;49(3):372-80 [9260748] Biochim Biophys Acta. 1998 Jan 19;1368(2):343-54 [9459611] Science. 1998 Apr 3;280(5360):69-77 [9525859] J Biol Chem. 2005 Mar 25;280(12):11127-33 [15632158] Biochemistry. 2005 Apr 26;44(16):6015-23 [15835890] Am J Physiol Renal Physiol. 2005 Jul;289(1):F217-24 [15741609] Science. 2005 Aug 5;309(5736):897-903 [16002581] Nature. 2005 Aug 11;436(7052):857-60 [16094370] Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15441-6 [16223877] Cell. 2005 Nov 4;123(3):463-75 [16269337] Neuron. 2005 Dec 8;48(5):719-25 [16337910] J Biol Chem. 2006 Jul 28;281(30):21332-44 [16679310] J Biol Chem. 2006 Jul 28;281(30):20673-9 [16720570] Nature. 2006 Aug 10;442(7103):696-9 [16799569] Biochemistry. 2006 Oct 3;45(39):11844-55 [17002285] Nature. 2006 Dec 7;444(7120):775-9 [17136096] Biophys J. 2007 Jan 1;92(1):L07-9 [17071657] Toxicon. 2007 Feb;49(2):213-30 [17097703] Anal Biochem. 2007 Mar 15;362(2):290-2 [17184723] Neuron. 1998 Oct;21(4):919-31 [9808476] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761. AN - 68435586; 17962472 AB - To evaluate the angiogenic inhibitory effects of an alpha(v)beta(3)/alpha(v)beta(5) integrin antagonist, EMD478761, released from a polymeric implant in a chick chorioallantoic membrane (CAM) assay and laser-induced experimental choroidal neovascularization (CNV) in rats. Polyvinyl alcohol-based reservoir implants releasing EMD478761 were designed for placement onto a CAM or intravitreally in rats. In vitro release rates of the implants were measured using HPLC. Angiogenesis was induced on 10-day-old chick embryos by basic fibroblast growth factor (bFGF), and areas of neovascularization were measured. Experimental CNV was induced in the Brown-Norway rat with a diode laser. EMD478761 or sham microimplants were placed within the vitreous chamber of Brown-Norway rats. Two weeks later, areas of CNV were determined by FITC-dextran staining of choroidal flatmounts. Sustained delivery of EMD478761 significantly inhibited bFGF-induced angiogenesis in CAM, as determined by a reduction in angiogenesis areas, without drug toxicity to the normal CAM vasculature. In an experimental rat model, intravitreal EMD478761 implants significantly suppressed laser-induced CNV compared with intravitreal sham implants, with the mean area reduced by 63% (P < 0.05). Sustained delivery of EMD478761demonstrates potent antiangiogenic properties in vivo. These results suggest that an EMD478761 implant may be beneficial in the treatment of neovascular ocular diseases. JF - Investigative ophthalmology & visual science AU - Fu, Yingli AU - Ponce, M Lourdes AU - Thill, Michelle AU - Yuan, Peng AU - Wang, Nam Sun AU - Csaky, Karl G AD - National Eye Institute, NIH, Bethesda, MD, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 5184 EP - 5190 VL - 48 IS - 11 SN - 0146-0404, 0146-0404 KW - Angiogenesis Inhibitors KW - 0 KW - Benzoxazines KW - Drug Implants KW - EMD478761 KW - Integrin alphaVbeta3 KW - Integrins KW - Receptors, Vitronectin KW - integrin alphaVbeta5 KW - Fibroblast Growth Factor 2 KW - 103107-01-3 KW - Index Medicus KW - Animals KW - Drug Delivery Systems KW - Chick Embryo KW - Disease Models, Animal KW - Laser Therapy KW - Rats, Inbred BN KW - Chromatography, High Pressure Liquid KW - Rats KW - Vitreous Body -- drug effects KW - Fibroblast Growth Factor 2 -- toxicity KW - Injections KW - Male KW - Neovascularization, Pathologic -- drug therapy KW - Receptors, Vitronectin -- antagonists & inhibitors KW - Integrin alphaVbeta3 -- antagonists & inhibitors KW - Neovascularization, Pathologic -- chemically induced KW - Integrins -- antagonists & inhibitors KW - Choroidal Neovascularization -- prevention & control KW - Choroidal Neovascularization -- pathology KW - Chorioallantoic Membrane -- blood supply KW - Benzoxazines -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68435586?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Angiogenesis+inhibition+and+choroidal+neovascularization+suppression+by+sustained+delivery+of+an+integrin+antagonist%2C+EMD478761.&rft.au=Fu%2C+Yingli%3BPonce%2C+M+Lourdes%3BThill%2C+Michelle%3BYuan%2C+Peng%3BWang%2C+Nam+Sun%3BCsaky%2C+Karl+G&rft.aulast=Fu&rft.aufirst=Yingli&rft.date=2007-11-01&rft.volume=48&rft.issue=11&rft.spage=5184&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pasteurella multocida bacteremia in asymptomatic plateletpheresis donors: a tale of two cats. AN - 68432107; 17958526 AB - Bacterial contamination of platelet (PLT) concentrates occurs in 1 in 1000 to 1 in 3000 components and has been a leading cause of transfusion-associated morbidity and mortality. Two cases of Pasteurella multocida bacteremia in asymptomatic plateletpheresis donors are reported. Clinical outcomes were profoundly different, emphasizing the importance of robust methods to detect bacterial contamination. The first case occurred before the implementation of bacterial testing of PLTs. A plateletpheresis component was collected from a 70-year-old man and transfused to an 88-year-old man, who developed rigors, tachycardia, and hypotension within 15 minutes of the start of the transfusion. Cardiopulmonary arrest ensued and he expired 6 hours after transfusion. Blood cultures collected after transfusion and cultures of the PLT component were positive for the presence of P. multocida. Investigation revealed that a feral cat had bitten the donor 100 minutes before his donation. He had not reported the event to the donor room staff. The second case involved a 74-year-old woman who developed a flulike syndrome 2 days after plateletpheresis donation. P. multocida was isolated in routine bacterial culture of her PLT component. The donor had several feral cats, and although there was no history of bite or scratch, one cat liked to lick her hands, which were chapped from gardening. Occult bacteremia with P. multocida transmitted by feral cats was the source of PLT contamination in two cases over 3 years. Bacterial testing of PLTs is critical in the prevention of transfusion-acquired sepsis and allows the identification and treatment of asymptomatic bacteremic donors. JF - Transfusion AU - Bryant, Barbara J AU - Conry-Cantilena, Cathy AU - Ahlgren, Alice AU - Felice, Anthony AU - Stroncek, David F AU - Gibble, Joan AU - Leitman, Susan F AD - Department of Transfusion Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1184, USA. bryantb2@cc.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1984 EP - 1989 VL - 47 IS - 11 SN - 0041-1132, 0041-1132 KW - Index Medicus KW - Fatal Outcome KW - Animals KW - Sepsis -- transmission KW - Aged, 80 and over KW - Humans KW - Cats KW - Aged KW - Sepsis -- microbiology KW - Male KW - Female KW - Pasteurella Infections -- transmission KW - Bacteremia -- transmission KW - Bacteremia -- microbiology KW - Pasteurella multocida KW - Blood Donors KW - Bites and Stings -- microbiology KW - Plateletpheresis -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68432107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Pasteurella+multocida+bacteremia+in+asymptomatic+plateletpheresis+donors%3A+a+tale+of+two+cats.&rft.au=Bryant%2C+Barbara+J%3BConry-Cantilena%2C+Cathy%3BAhlgren%2C+Alice%3BFelice%2C+Anthony%3BStroncek%2C+David+F%3BGibble%2C+Joan%3BLeitman%2C+Susan+F&rft.aulast=Bryant&rft.aufirst=Barbara&rft.date=2007-11-01&rft.volume=47&rft.issue=11&rft.spage=1984&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prolonged attenuation of amygdala-kindled seizure measures in rats by convection-enhanced delivery of the N-type calcium channel antagonists omega-conotoxin GVIA and omega-conotoxin MVIIA. AN - 68426997; 17717191 AB - Convection-enhanced delivery (CED) permits the homogeneous distribution of therapeutic agents throughout localized regions of the brain parenchyma without causing tissue damage as occurs with bolus injection. Here, we examined whether CED infusion of the N-type calcium channel antagonists omega-conotoxin GVIA (omega-CTX-G) and omega-conotoxin MVIIA (omega-CTX-M) can attenuate kindling measures in fully amygdala-kindled rats. Rats were implanted with a combination infusion cannula-stimulating electrode assembly into the right basolateral amygdala. Fully kindled animals received infusions of vehicle, omega-CTX-G (0.005, 0.05, and 0.5 nmol), omega-CTX-M (0.05, 0.15, and 0.5 nmol), proteolytically inactivated omega-CTX-M (0.5 nmol), or carbamazepine (500 nmol) into the stimulation site. CED of omega-CTX-G and omega-CTX-M over a 20-min period resulted in a dose-dependent increase in the afterdischarge threshold and a decrease in the afterdischarge duration and behavioral seizure score and duration during a period of 20 min to 1 week after the infusion, indicating an inhibitory effect on the triggering and expression of kindled seizures. The protective effects of omega-conotoxins reached a maximum at 48 h postinfusion, and then they gradually resolved over the next 5 days. In contrast, carbamazepine was active at 20 min but not at 24 h after the infusion, whereas CED of vehicle or inactivated omega-CTX-M had no effect. Except for transient tremor in some rats receiving the highest toxin doses, no adverse effects were observed. These results indicate that local CED of high-molecular-weight presynaptic N-type calcium channel blockers can produce long-lasting inhibition of brain excitability and that they may provide prolonged seizure protection in focal seizure disorders. JF - The Journal of pharmacology and experimental therapeutics AU - Gasior, Maciej AU - White, Natalie A AU - Rogawski, Michael A AD - Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 458 EP - 468 VL - 323 IS - 2 SN - 0022-3565, 0022-3565 KW - Calcium Channel Blockers KW - 0 KW - omega-Conotoxins KW - Carbamazepine KW - 33CM23913M KW - ziconotide KW - 7I64C51O16 KW - omega-Conotoxin GVIA KW - 92078-76-7 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Dose-Response Relationship, Drug KW - Carbamazepine -- pharmacology KW - Motor Activity -- drug effects KW - Time Factors KW - Male KW - Injections, Intraventricular KW - omega-Conotoxins -- metabolism KW - Kindling, Neurologic -- drug effects KW - omega-Conotoxin GVIA -- metabolism KW - omega-Conotoxin GVIA -- administration & dosage KW - omega-Conotoxins -- administration & dosage KW - Calcium Channel Blockers -- administration & dosage KW - Amygdala -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Prolonged+attenuation+of+amygdala-kindled+seizure+measures+in+rats+by+convection-enhanced+delivery+of+the+N-type+calcium+channel+antagonists+omega-conotoxin+GVIA+and+omega-conotoxin+MVIIA.&rft.au=Gasior%2C+Maciej%3BWhite%2C+Natalie+A%3BRogawski%2C+Michael+A&rft.aulast=Gasior&rft.aufirst=Maciej&rft.date=2007-11-01&rft.volume=323&rft.issue=2&rft.spage=458&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Pharmacol. 1991 Jul;103(3):1733-9 [1657265] Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):5058-62 [1317580] Eur J Pharmacol. 1989 Dec 19;174(2-3):261-6 [2560980] Neurosci Lett. 1988 Aug 15;91(1):84-8 [2845309] Biochemistry. 1987 Apr 21;26(8):2086-90 [2441741] J Biol Chem. 1986 May 15;261(14):6230-3 [2939072] Science. 1985 Dec 20;230(4732):1338-43 [4071055] Neuropharmacology. 1984 Oct;23(10):1117-23 [6521848] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Brain Res Bull. 1981 Dec;7(6):629-33 [7326579] Epilepsia. 1976 Jun;17(2):197-206 [947748] Eur J Pharmacol. 1993 Jul 20;238(2-3):383-6 [8104812] Neuron. 1993 Nov;11(5):895-902 [7902110] Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2076-80 [8134351] Neuropharmacology. 1994 Feb;33(2):255-8 [8035912] J Neurosci. 1994 Sep;14(9):5613-22 [8083757] Pain. 1995 Jan;60(1):83-90 [7715945] J Neurosurg. 1995 Jun;82(6):1021-9 [7539062] Biochemistry. 1995 Jun 27;34(25):8076-81 [7794920] Annu Rev Pharmacol Toxicol. 1995;35:707-34 [7598513] Pflugers Arch. 1995 Apr;429(6):873-5 [7603842] Int J Pept Protein Res. 1995 Sep-Oct;46(3-4):320-5 [8537186] Psychopharmacology (Berl). 1996 Jul;126(1):85-90 [8853221] Trends Neurosci. 1997 May;20(5):204-12 [9141196] J Neurosurg. 1999 Feb;90(2):315-20 [9950503] J Neurosurg. 1999 Feb;90(2):321-31 [9950504] Epilepsy Res. 1999 Feb;33(2-3):159-67 [10094427] Neurology. 2005 Jun 28;64(12 Suppl 3):S2-11 [15994220] J Mol Recognit. 2000 Mar-Apr;13(2):55-70 [10822250] Peptides. 2000 Apr;21(4):491-501 [10822104] Curr Opin Oncol. 2000 May;12(3):187-93 [10841189] J Neurosurg. 2002 Oct;97(4):905-13 [12405380] Neurosurgery. 2003 Feb;52(2):388-93; discussion 393-4 [12535369] J Biol Chem. 2003 May 30;278(22):20171-8 [12654924] Epilepsia. 2003 Nov;44(11):1425-33 [14636351] Brain Res Brain Res Rev. 2004 Mar;44(2-3):141-53 [15003390] Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):269-79 [4110396] Electroencephalogr Clin Neurophysiol. 1972 Mar;32(3):281-94 [4110397] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. AN - 68422899; 17616639 AB - CD4+CD25+Foxp3+ regulatory T (Treg) cells have been implicated in the lack of effective antitumor immunity. Denileukin diftitox (DAB(389)IL-2), a fusion protein of interleukin 2 (IL-2) and diphtheria toxin, provides a means of targeting Treg cells. In this study, we examined (1) the effect of denileukin diftitox on the deletion of Treg cells in various lymphoid compartments and (2) the dose scheduling of denileukin diftitox in combination with a recombinant poxviral vaccine to enhance antigen-specific immune responses. Treg cells in spleen, peripheral blood, and bone marrow of normal C57BL/6 mice were variously reduced after a single intraperitoneal injection of denileukin diftitox; the reduction was evident within 24 hours and lasted approximately 10 days. Injection of denileukin diftitox 1 day before vaccination enhanced antigen-specific T-cell responses above levels induced by vaccination alone. These studies show for the first time in a murine model (1) the differential effects of denileukin diftitox on Treg cells in different cellular compartments, (2) the advantage of combining denileukin diftitox with a vaccine to enhance antigen-specific T-cell immune responses, (3) the lack of inhibition by denileukin diftitox of host immune responses directed against a live viral vector, and (4) the importance of dose scheduling of denileukin diftitox when used in combination with a vaccine. JF - Blood AU - Litzinger, Mary T AU - Fernando, Romaine AU - Curiel, Tyler J AU - Grosenbach, Douglas W AU - Schlom, Jeffrey AU - Palena, Claudia AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 3192 EP - 3201 VL - 110 IS - 9 SN - 0006-4971, 0006-4971 KW - Diphtheria Toxin KW - 0 KW - Immunotoxins KW - Interleukin-2 KW - Recombinant Fusion Proteins KW - Viral Vaccines KW - denileukin diftitox KW - 25E79B5CTM KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Drug Administration Schedule KW - Combined Modality Therapy KW - Mice KW - Mice, Inbred BALB C KW - Mice, Transgenic KW - Recombinant Fusion Proteins -- administration & dosage KW - Lymphocyte Count KW - Cells, Cultured KW - Mice, Inbred C57BL KW - Recombinant Fusion Proteins -- pharmacology KW - Influenza A virus -- immunology KW - Immunotoxins -- pharmacology KW - Poxviridae -- immunology KW - Female KW - Interleukin-2 -- pharmacology KW - Interleukin-2 -- administration & dosage KW - T-Lymphocytes, Regulatory -- drug effects KW - Diphtheria Toxin -- administration & dosage KW - T-Lymphocytes, Regulatory -- cytology KW - Immunity, Cellular -- drug effects KW - Diphtheria Toxin -- pharmacology KW - Viral Vaccines -- immunology KW - Viral Vaccines -- therapeutic use KW - T-Lymphocytes, Regulatory -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68422899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Blood&rft.atitle=IL-2+immunotoxin+denileukin+diftitox+reduces+regulatory+T+cells+and+enhances+vaccine-mediated+T-cell+immunity.&rft.au=Litzinger%2C+Mary+T%3BFernando%2C+Romaine%3BCuriel%2C+Tyler+J%3BGrosenbach%2C+Douglas+W%3BSchlom%2C+Jeffrey%3BPalena%2C+Claudia&rft.aulast=Litzinger&rft.aufirst=Mary&rft.date=2007-11-01&rft.volume=110&rft.issue=9&rft.spage=3192&rft.isbn=&rft.btitle=&rft.title=Blood&rft.issn=00064971&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2003 Oct 1;9(12):4404-8 [14555512] Cancer. 2003 Sep 1;98(5):1089-99 [12942579] J Immunol. 2003 Dec 1;171(11):5931-9 [14634104] Trends Mol Med. 2003 Dec;9(12):526-34 [14659467] J Immunol. 2004 May 15;172(10):6265-71 [15128815] Clin Cancer Res. 2004 May 15;10(10):3572-5 [15161717] Nat Med. 2004 Sep;10(9):942-9 [15322536] J Natl Cancer Inst. 1992 Jul 15;84(14):1084-91 [1619682] J Virol. 1996 Jan;70(1):165-71 [8523521] Cancer Res. 1996 Jun 1;56(11):2590-5 [8653702] Blood. 1998 Jan 15;91(2):399-405 [9427692] Cancer Res. 1998 Apr 1;58(7):1469-77 [9537250] Cancer Res. 1999 Jul 1;59(13):3128-33 [10397255] Cancer Res. 2004 Nov 15;64(22):8451-5 [15548717] Hum Immunol. 2005 Jan;66(1):13-20 [15620457] Expert Rev Anticancer Ther. 2005 Feb;5(1):33-8 [15757436] Blood. 2005 Apr 1;105(7):2862-8 [15591121] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] Clin Cancer Res. 2005 Jun 15;11(12):4533-44 [15958639] Trends Immunol. 2005 Jul;26(7):360-6 [15978522] J Immunother. 2005 Nov-Dec;28(6):582-92 [16224276] Am J Reprod Immunol. 2005 Dec;54(6):369-77 [16305662] J Clin Invest. 2005 Dec;115(12):3623-33 [16308572] J Invest Dermatol. 2006 Mar;126(3):575-83 [16410787] J Immunol. 2006 Mar 1;176(5):2722-9 [16493027] J Immunol. 2006 Jul 1;177(1):84-91 [16785502] Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4294-305 [16857805] Eur J Immunol. 2007 Jan;37(1):129-38 [17154262] Br J Haematol. 2007 Feb;136(3):439-47 [17233846] Int J Cancer. 2007 Jun 15;120(12):2723-33 [17315189] J Immunol. 1999 Nov 15;163(10):5211-8 [10553041] Cancer Res. 1999 Nov 15;59(22):5800-7 [10582702] Cancer Res. 2001 Jan 1;61(1):206-14 [11196163] Cancer Res. 2001 Jun 1;61(11):4497-505 [11389081] Cancer Res. 2001 Jun 15;61(12):4766-72 [11406550] J Immunol. 2001 Aug 1;167(3):1245-53 [11466340] J Immunol. 2002 Sep 1;169(5):2756-61 [12193750] Cancer Res. 2002 Oct 15;62(20):5770-7 [12384537] Cancer Res. 2002 Dec 1;62(23):6944-51 [12460911] Clin Cancer Res. 2003 Feb;9(2):606-12 [12576425] Immunology. 2003 Jul;109(3):319-25 [12807474] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9458-63 [12869693] Curr Opin Immunol. 2003 Dec;15(6):690-6 [14630204] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic microglial activation and progressive dopaminergic neurotoxicity. AN - 68422814; 17956294 AB - PD (Parkinson's disease) is characterized by the selective and progressive loss of DA neurons (dopaminergic neurons) in the substantia nigra. Inflammation and activation of microglia, the resident innate immune cell in the brain, have been strongly linked to neurodegenerative diseases, such as PD. Microglia can respond to immunological stimuli and neuronal death to produce a host of toxic factors, including cytokines and ROS (reactive oxygen species). Microglia can also become persistently activated after a single stimulus and maintain the elevated production of both cytokines and ROS, long after the instigating stimulus is gone. Current reports suggest that this chronic microglial activation may be fuelled by either dying/damaged neurons or autocrine and paracrine signals from local glial cells, such as cytokines. Here, we review proposed mechanisms responsible for chronic neuroinflammation and explain the interconnected relationship between deleterious microglial activation, DA neuron damage and neurodegenerative disease. JF - Biochemical Society transactions AU - Block, M L AU - Hong, J-S AD - Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, U.S.A. mblock@vcu.edu Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1127 EP - 1132 VL - 35 SN - 0300-5127, 0300-5127 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Humans KW - Oxidative Stress KW - Neurons -- drug effects KW - Microglia -- metabolism KW - Dopamine -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68422814?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Society+transactions&rft.atitle=Chronic+microglial+activation+and+progressive+dopaminergic+neurotoxicity.&rft.au=Block%2C+M+L%3BHong%2C+J-S&rft.aulast=Block&rft.aufirst=M&rft.date=2007-11-01&rft.volume=35&rft.issue=&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Biochemical+Society+transactions&rft.issn=03005127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-05 N1 - Date created - 2007-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anthrax protective antigen cleavage and clearance from the blood of mice and rats. AN - 68405768; 17724066 AB - Bacillus anthracis protective antigen (PA) is an 83-kDa (PA83) protein that is cleaved to the 63-kDa protein (PA63) as an essential step in binding and internalizing lethal factor (LF). To assess in vivo receptor saturating PA concentrations, we injected mice with PA variants and measured the PA remaining in the blood at various times using PA83- and PA63-specific enzyme-linked immunosorbent assays. We found that both wild-type PA (WT-PA) and a receptor-binding-defective mutant (Ub-PA) were cleaved to PA63 independent of their ability to bind cells. This suggested a PA-acting protease activity in the blood. The protease cleaved PA at the furin cleavage sequence because furin site-modified PA mutants were not cleaved. Cleavage measured in vitro was leupeptin sensitive and dependent on calcium. Cell surface cleavage was important for toxin clearance, however, as Ub-PA and uncleavable PA mutants were cleared at slower rates than WT-PA. The cell binding-independent cleavage of PA was also verified by using Ub-PA (which is still cleaved) to rescue mice from toxin challenge by competitively binding circulating LF. This mutant was able to rescue mice even when given 12 h before toxin challenge. Its therapeutic ability was comparable to that of dominant-negative PA, which binds cells but does not allow LF translocation, and to the protection afforded through receptor clearance by WT-PA and uncleavable receptor binding-competent mutants. The PA cleavage and clearance observed in mice did not appear to have a role in the differential mouse susceptibility as it occurred similarly in lethal toxin (LT)-resistant DBA/2J and LT-sensitive BALB/cJ mice. Interestingly, PA63 was not found in LT-resistant or -sensitive rats and PA83 clearance was slower in rats than in mice. Finally, to determine the minimum amount of PA required in circulation for LT toxicity in mice, we administered time-separated injections of PA and LF and showed that lethality of LF for mice after PA was no longer measurable in circulation, suggesting active PA sequestration at tissue surfaces. JF - Infection and immunity AU - Moayeri, Mahtab AU - Wiggins, Jason F AU - Leppla, Stephen H AD - Laboratory of Bacterial Diseases, Building 33, Room 1W20, NIAID, NIH, Bethesda, MD 20892-3202, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 5175 EP - 5184 VL - 75 IS - 11 SN - 0019-9567, 0019-9567 KW - Antidotes KW - 0 KW - Antigens, Bacterial KW - Bacterial Toxins KW - Coenzymes KW - Cysteine Proteinase Inhibitors KW - Leupeptins KW - anthrax toxin KW - Peptide Hydrolases KW - EC 3.4.- KW - leupeptin KW - J97339NR3V KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Metabolic Clearance Rate KW - Calcium -- pharmacology KW - Mice KW - Anthrax -- prevention & control KW - Coenzymes -- pharmacology KW - Mice, Inbred BALB C KW - Mice, Inbred DBA KW - Rats KW - Cysteine Proteinase Inhibitors -- pharmacology KW - Leupeptins -- pharmacology KW - Rats, Inbred F344 KW - Peptide Hydrolases -- metabolism KW - Enzyme-Linked Immunosorbent Assay KW - Protein Binding -- genetics KW - Antidotes -- pharmacology KW - Mutation KW - Survival Analysis KW - Antigens, Bacterial -- toxicity KW - Bacterial Toxins -- antagonists & inhibitors KW - Bacterial Toxins -- metabolism KW - Antigens, Bacterial -- metabolism KW - Bacterial Toxins -- pharmacokinetics KW - Blood -- metabolism KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68405768?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=Anthrax+protective+antigen+cleavage+and+clearance+from+the+blood+of+mice+and+rats.&rft.au=Moayeri%2C+Mahtab%3BWiggins%2C+Jason+F%3BLeppla%2C+Stephen+H&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2007-11-01&rft.volume=75&rft.issue=11&rft.spage=5175&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-29 N1 - Date created - 2007-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Nov 1;60(21):6061-7 [11085528] Protein Expr Purif. 2000 Apr;18(3):293-302 [10733882] Science. 2001 Apr 27;292(5517):695-7 [11326092] J Biol Chem. 2001 May 25;276(21):17976-84 [11278833] Nature. 2001 Nov 8;414(6860):225-9 [11700562] Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):657-62 [12525700] J Cell Biol. 2003 Feb 3;160(3):321-8 [12551953] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4 [12700348] J Biol Chem. 2003 Aug 15;278(33):30936-44 [12771151] J Clin Invest. 2003 Sep;112(5):670-82 [12952916] Infect Immun. 1988 Jul;56(7):1807-13 [3384478] J Gen Microbiol. 1992 Mar;138(3):543-9 [1593265] J Biol Chem. 1992 Aug 15;267(23):16396-402 [1644824] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10277-81 [1438214] Infect Immun. 1995 Jan;63(1):82-7 [7806387] Microbiology. 1996 Mar;142 ( Pt 3):707-15 [8868446] Mol Med. 1998 Feb;4(2):87-95 [9508786] Arch Biochem Biophys. 2006 Feb 1;446(1):52-9 [16384550] Clin Vaccine Immunol. 2006 Jun;13(6):671-7 [16760326] Infect Immun. 2006 Oct;74(10):5871-6 [16988266] Science. 1998 May 1;280(5364):734-7 [9563949] Biochem Biophys Res Commun. 1998 Jul 30;248(3):706-11 [9703991] Proc Soc Exp Biol Med. 1963 Nov;114:294-7 [14101169] J Biol Chem. 2005 Mar 18;280(11):10834-9 [15644338] J Biol Chem. 2005 Oct 7;280(40):34056-62 [16087661] Int J Med Microbiol. 2000 Oct;290(4-5):421-7 [11111921] N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Inclusion of biomarkers for detecting perturbations in the heart and lung and lipid/carbohydrate metabolism in National Toxicology Program studies. AN - 68391314; 17490986 AB - Environmental factors and exposures may contribute to many serious diseases afflicting humans. Biomarkers are useful to understand disease processes and identify early events leading to disease. The National Toxicology Program (NTP) convened a workshop in September 2006 to help identify biomarkers that could be used in toxicology studies with rodents to predict disease outcome and detect early events in disease processes. Expert scientists reviewed biomarkers for disease/injury related to the heart, lung, and/or changes in lipid/carbohydrate metabolism and made recommendations for those that could be incorporated into NTP studies on a routine or selective basis. Although numerous biomarkers were discussed, only a few were considered amenable for routine use. This article summarizes recommendations for the most promising biomarkers and presents the NTP perspective on those that will be included in the bioassay program on a routine or special study basis. Breakout group reports and additional information on the workshop, including participants, presentations, and background materials, are posted on the NTP Web site http://ntp.niehs.nih.gov/go/20940. JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Dunnick, June K AU - Thayer, Kristina A AU - Travlos, Gregory S Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 29 EP - 35 VL - 100 IS - 1 KW - Biomarkers KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Humans KW - Lung Injury KW - Program Development KW - Biological Assay -- standards KW - Guidelines as Topic KW - Heart Injuries -- chemically induced KW - Heart Injuries -- metabolism KW - Risk Assessment KW - Toxicology -- standards KW - Lipid Metabolism -- drug effects KW - Carbohydrate Metabolism -- drug effects KW - Lung -- drug effects KW - Heart -- drug effects KW - Lung -- metabolism KW - Biomarkers -- blood KW - Myocardium -- metabolism KW - Toxicity Tests -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68391314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Inclusion+of+biomarkers+for+detecting+perturbations+in+the+heart+and+lung+and+lipid%2Fcarbohydrate+metabolism+in+National+Toxicology+Program+studies.&rft.au=Dunnick%2C+June+K%3BThayer%2C+Kristina+A%3BTravlos%2C+Gregory+S&rft.aulast=Dunnick&rft.aufirst=June&rft.date=2007-11-01&rft.volume=100&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Am Coll Cardiol. 2006 Jul 4;48(1):1-11 [16814641] Toxicol Sci. 2006 Jul;92(1):286-94 [16624848] N Engl J Med. 2006 Jul 20;355(3):241-50 [16855264] Pharmacogenomics. 2006 Jul;7(5):773-82 [16886901] Biochem J. 2006 Oct 15;399(2):e11-3 [16987105] COPD. 2005 Sep;2(3):289-302 [17146994] JAMA. 2000 Apr 5;283(13):1695-702 [10755495] Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:155-9 [16092723] Control Clin Trials. 2001 Oct;22(5):485-502 [11578783] Circulation. 2002 Feb 5;105(5):595-601 [11827925] Physiol Genomics. 2003 Oct 17;15(2):105-14 [12865503] Toxicol Pathol. 2004 Jan-Feb;32(1):106-21 [14713555] Histopathology. 2004 Jan;44(1):47-53 [14717669] N Engl J Med. 2004 Jun 3;350(23):2362-74 [15175438] Toxicol Sci. 2004 Sep;81(1):243-52 [15201436] Hum Mol Genet. 2004 Oct 1;13 Spec No 2:R217-24 [15358728] Toxicol Sci. 2004 Oct;81(2):512-7 [15229369] Comp Biochem Physiol B. 1985;81(4):819-22 [4042626] Toxicology. 1989 Aug;57(3):255-66 [2756527] Eur J Clin Chem Clin Biochem. 1993 Oct;31(10):633-7 [8292663] Med Phys. 2004 Dec;31(12):3324-9 [15651615] Prog Cardiovasc Dis. 2004 Nov-Dec;47(3):207-16 [15736586] Clin Chem. 2005 Mar;51(3):486-93 [15738513] Lancet. 2005 Apr 16-22;365(9468):1415-28 [15836891] Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2219-24 [15653753] Mol Imaging. 2005 Apr-Jun;4(2):110-6 [16105509] Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11478-81 [11027348] Inhal Toxicol. 2005 Nov;17(12):657-70 [16087572] Clin Chem. 2005 May;51(5):810-24 [15774573] Am J Respir Crit Care Med. 2005 Dec 1;172(11):1399-411 [16100012] Invest Radiol. 2005 Dec;40(12):777-83 [16304481] N Engl J Med. 2006 Feb 9;354(6):610-21 [16467548] Toxicol Pathol. 2006;34(1):111-7 [16507552] Toxicol Pathol. 2006;34(2):152-63 [16537294] JAMA. 2006 Apr 12;295(14):1688-97 [16609091] Annu Rev Biochem. 2006;75:367-401 [16756496] Toxicol Sci. 2006 Aug;92(2):545-59 [16699168] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats. AN - 68389239; 17888459 AB - It was recently reported that levo-tetrahydropalmatine (l-THP), a dopamine (DA) D1 and D2 receptor antagonist purified from the Chinese herb Stephanie, appears to be effective in attenuating cocaine self-administration, cocaine-triggered reinstatement and cocaine-induced conditioned place preference in preclinical animal models. The present study was designed to contrast l-THP's effects on cocaine self-administration under fixed-ratio (FR) and progressive-ratio (PR) reinforcement, and to study l-THP's effects on cocaine-enhanced brain stimulation reward (BSR). Systemic administration of l-THP produced dose-dependent, biphasic effects, i.e., low-to-moderate doses (1, 3, 10 mg/kg) increased, while a high dose (20 mg/kg) inhibited cocaine self-administration behavior under FR2 reinforcement. The increased cocaine self-administration is likely a compensatory response to a reduction in cocaine's rewarding effects, because the same low doses of l-THP dose-dependently attenuated cocaine self-administration under PR reinforcement and also attenuated cocaine-enhanced BSR. These attenuations of PR cocaine self-administration and cocaine-enhanced BSR are unlikely due to l-THP-induced sedation or locomotor inhibition, because only 10 mg/kg, but not 1-3 mg/kg, of l-THP inhibited locomotion, sucrose self-administration and asymptotic operant performance in the BSR paradigm. In vivo microdialysis demonstrated that l-THP slightly elevates extracellular nucleus accumbens DA by itself, but dose-dependently potentiates cocaine-augmented DA, suggesting that a postsynaptic, rather than presynaptic, DA receptor antagonism underlies l-THP's actions on cocaine reward. Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction. JF - Neuropharmacology AU - Xi, Zheng-Xiong AU - Yang, Zheng AU - Li, Shi-Jiang AU - Li, Xia AU - Dillon, Christopher AU - Peng, Xiao-Qing AU - Spiller, Krista AU - Gardner, Eliot L AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. zxi@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 771 EP - 782 VL - 53 IS - 6 SN - 0028-3908, 0028-3908 KW - Antipsychotic Agents KW - 0 KW - Berberine Alkaloids KW - tetrahydropalmatine KW - 3X69CO5I79 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Stereoisomerism KW - Reinforcement Schedule KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Nucleus Accumbens -- drug effects KW - Antipsychotic Agents -- therapeutic use KW - Disease Models, Animal KW - Dopamine -- metabolism KW - Rats KW - Microdialysis KW - Behavior, Animal -- drug effects KW - Self Administration KW - Nucleus Accumbens -- metabolism KW - Drug Antagonism KW - Male KW - Reward KW - Brain -- drug effects KW - Cocaine-Related Disorders -- drug therapy KW - Cocaine -- pharmacology KW - Berberine Alkaloids -- therapeutic use KW - Cocaine -- administration & dosage KW - Cocaine -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68389239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Levo-tetrahydropalmatine+inhibits+cocaine%27s+rewarding+effects%3A+experiments+with+self-administration+and+brain-stimulation+reward+in+rats.&rft.au=Xi%2C+Zheng-Xiong%3BYang%2C+Zheng%3BLi%2C+Shi-Jiang%3BLi%2C+Xia%3BDillon%2C+Christopher%3BPeng%2C+Xiao-Qing%3BSpiller%2C+Krista%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2007-11-01&rft.volume=53&rft.issue=6&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-21 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Alcohol Depend. 1987 Jan;19(1):17-27 [3816536] Psychopharmacology (Berl). 1986;89(1):89-93 [3090599] Psychiatry Res. 1989 Feb;27(2):117-25 [2652168] Pharmacol Biochem Behav. 1989 Mar;32(3):691-7 [2662223] Zhongguo Yao Li Xue Bao. 1989 Mar;10(2):104-10 [2530755] Brain Res. 1994 Jul 18;651(1-2):283-92 [7922577] Psychopharmacology (Berl). 1995 May;119(2):127-32 [7659759] Mol Neurobiol. 1995 Aug-Dec;11(1-3):1-19 [8561954] Trends Pharmacol Sci. 1996 Jul;17(7):260-4 [8756185] Annu Rev Neurosci. 1996;19:319-40 [8833446] Pharmacol Biochem Behav. 1997 Jul;57(3):441-7 [9218268] J Neurosci. 1997 Nov 1;17(21):8580-7 [9334429] J Pharmacol Exp Ther. 1997 Dec;283(3):1160-7 [9399989] Zhongguo Yao Li Xue Bao. 1997 May;18(3):225-30 [10072938] Eur Neuropsychopharmacol. 1999 Jan;9(1-2):1-7 [10082221] Acta Pharmacol Sin. 2005 May;26(5):533-8 [15842769] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] J Comp Neurol. 2005 Dec 5;493(1):115-21 [16254990] CNS Neurol Disord Drug Targets. 2006 Feb;5(1):25-43 [16613552] J Neurosci. 2006 Aug 16;26(33):8531-6 [16914679] Acta Pharmacol Sin. 2006 Sep;27(9):1111-8 [16923330] Psychopharmacology (Berl). 2007 Jul;192(4):581-91 [17361394] CNS Drug Rev. 2007 Summer;13(2):240-59 [17627675] J Pharmacol Exp Ther. 1994 Jul;270(1):209-18 [8035317] Ann Neurol. 2000 Apr;47(4 Suppl 1):S53-9 [10762132] Eur Neuropsychopharmacol. 2000 Sep;10(5):325-32 [10974602] J Pharmacol Exp Ther. 2000 Dec;295(3):1232-40 [11082460] Am J Addict. 2000 Fall;9(4):285-313 [11155784] Psychiatry Res. 2001 Jul 24;102(3):227-33 [11440773] Psychopharmacology (Berl). 2001 Jun;155(4):330-7 [11441422] Psychopharmacology (Berl). 2001 Jun;155(4):338-47 [11441423] Trends Pharmacol Sci. 2002 Jan;23(1):4-7 [11804640] J Neurosci. 2002 Apr 15;22(8):3293-301 [11943831] Alcohol Alcohol. 2002 Sep-Oct;37(5):485-94 [12217944] Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82 [12373428] Drugs. 2004;64(14):1547-73 [15233592] Behav Neurosci. 1987 Apr;101(2):209-14 [3580122] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imagen: implications for addiction science and science policy. AN - 68383265; 17935578 JF - Addiction (Abingdon, England) AU - Heilig, Markus AD - NIAAA, 10 Center Drive, 10/1-5334, Bethesda, MD 20892-1108, USA. mheilig@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 1699 EP - 1700 VL - 102 IS - 11 SN - 0965-2140, 0965-2140 KW - Index Medicus KW - Humans KW - Predictive Value of Tests KW - Behavioral Research -- standards KW - Male KW - Female KW - Policy Making KW - Behavior, Addictive -- etiology KW - Substance-Related Disorders -- etiology KW - Science KW - Behavior, Addictive -- genetics KW - Substance-Related Disorders -- genetics KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68383265?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+%28Abingdon%2C+England%29&rft.atitle=Imagen%3A+implications+for+addiction+science+and+science+policy.&rft.au=Heilig%2C+Markus&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2007-11-01&rft.volume=102&rft.issue=11&rft.spage=1699&rft.isbn=&rft.btitle=&rft.title=Addiction+%28Abingdon%2C+England%29&rft.issn=09652140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-07 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Addiction. 2007 Nov;102(11):1689-95 [17935575] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dynorphin and the pathophysiology of drug addiction. AN - 68334302; 17868902 AB - Drug addiction is a chronic relapsing disease in which drug administration becomes the primary stimulus that drives behavior regardless of the adverse consequence that may ensue. As drug use becomes more compulsive, motivation for natural rewards that normally drive behavior decreases. The discontinuation of drug use is associated with somatic signs of withdrawal, dysphoria, anxiety, and anhedonia. These consequences of drug use are thought to contribute to the maintenance of drug use and to the reinstatement of compulsive drug use that occurs during the early phase of abstinence. Even, however, after prolonged periods of abstinence, 80-90% of human addicts relapse to addiction, suggesting that repeated drug use produces enduring changes in brain circuits that subserve incentive motivation and stimulus-response (habit) learning. A major goal of addiction research is the identification of the neural mechanisms by which drugs of abuse produce these effects. This article will review data showing that the dynorphin/kappa-opioid receptor (KOPr) system serves an essential function in opposing alterations in behavior and brain neurochemistry that occur as a consequence of repeated drug use and that aberrant activity of this system may not only contribute to the dysregulation of behavior that characterizes addiction but to individual differences in vulnerability to the pharmacological actions of cocaine and alcohol. We will provide evidence that the repeated administration of cocaine and alcohol up-regulates the dynorphin/KOPr system and that pharmacological treatments that target this system may prove effective in the treatment of drug addiction. JF - Pharmacology & therapeutics AU - Shippenberg, T S AU - Zapata, A AU - Chefer, V I AD - Integrative Neuroscience Section, NIH/NIDA Intramural Research Program, 333 Cassell Drive, Baltimore, MD 21224, USA. tshippen@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 306 EP - 321 VL - 116 IS - 2 SN - 0163-7258, 0163-7258 KW - Receptors, Opioid, kappa KW - 0 KW - Ethanol KW - 3K9958V90M KW - Dynorphins KW - 74913-18-1 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Animals KW - Ethanol -- pharmacology KW - Humans KW - Cocaine-Related Disorders -- physiopathology KW - Ethanol -- toxicity KW - Cocaine -- toxicity KW - Brain -- metabolism KW - Up-Regulation KW - Behavior, Addictive -- physiopathology KW - Alcoholism -- physiopathology KW - Cocaine -- pharmacology KW - Substance-Related Disorders -- physiopathology KW - Receptors, Opioid, kappa -- metabolism KW - Dynorphins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68334302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Dynorphin+and+the+pathophysiology+of+drug+addiction.&rft.au=Shippenberg%2C+T+S%3BZapata%2C+A%3BChefer%2C+V+I&rft.aulast=Shippenberg&rft.aufirst=T&rft.date=2007-11-01&rft.volume=116&rft.issue=2&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-10 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2003 Feb;17(3):590-6 [12581176] J Pharmacol Exp Ther. 2003 Apr;305(1):323-30 [12649385] Eur J Neurosci. 2003 Mar;17(5):1053-66 [12653981] J Neurosci. 2003 Apr 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Nov 1;218(2):79-82 [8945732] Prog Neurobiol. 1996 Dec;50(5-6):557-83 [9015827] J Pharmacol Exp Ther. 2006 Jan;316(1):440-7 [16223871] Neurosci Biobehav Rev. 2006;30(2):126-47 [16183121] Neuroscience. 2006;137(1):187-96 [16289352] Neuropsychopharmacology. 2006 Feb;31(2):396-405 [16034441] Brain. 2006 Mar;129(Pt 3):642-54 [16399805] Br J Pharmacol. 2006 Feb;147(4):360-70 [16402046] Neuropsychopharmacology. 2006 Apr;31(4):787-94 [16123754] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Individualized pharmacotherapy with paclitaxel. AN - 68334076; 17906456 AB - More than two decades of clinical experience with paclitaxel as an anticancer drug have contributed significantly to the optimization of today's application schemes and patients' safety. Recent knowledge about interindividual pharmacokinetic variability and population modeling provides a novel scientific basis for an improved and individualized therapeutic approach. Age, gender and bilirubin levels were shown to be associated with an altered pharmacokinetic profile. Prolonged exposure to paclitaxel concentrations exceeding the thresholds of 0.05 or 0.1 micromol/l were predictive for neutropenia, peripheral neuropathy and survival. Due to substantial interindividual diversity observed in paclitaxel pharmacokinetics actual research focuses on common single nucleotide polymorphisms in genes encoding metabolizing enzymes and drug transporters such as CYP450, P-glycoprotein and the organic anion transporting polypeptide OATP1B3. Polymorphisms of ABCB1 encoding P-glycoprotein were found to be associated with neutropenia and neurotoxicity. A haplotype of CYP3A4 was associated with paclitaxel pharmacokinetics. Several demographic, pharmacokinetic and genetic covariables that have been identified to influence toxicity and tumor responses following chemotherapy with paclitaxel are discussed with regard to their transferability into a bedside approach. JF - Current opinion in oncology AU - Mielke, Stephan AD - Department of Hematology and Oncology, University Medical Center, Freiburg, Germany. mielkes@nhlbi.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 586 EP - 589 VL - 19 IS - 6 SN - 1040-8746, 1040-8746 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Organic Anion Transporters KW - P-Glycoprotein KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A4 protein, human KW - EC 1.14.13.67 KW - Cytochrome P-450 CYP3A KW - EC 1.14.14.1 KW - Paclitaxel KW - P88XT4IS4D KW - Bilirubin KW - RFM9X3LJ49 KW - Index Medicus KW - Age Factors KW - P-Glycoprotein -- metabolism KW - Dose-Response Relationship, Drug KW - Bilirubin -- metabolism KW - Humans KW - Cytochrome P-450 Enzyme System -- metabolism KW - Organic Anion Transporters -- metabolism KW - Pharmacokinetics KW - Male KW - Female KW - Paclitaxel -- administration & dosage KW - Polymorphism, Single Nucleotide KW - Drug Administration Schedule KW - Paclitaxel -- therapeutic use KW - Pharmacogenetics -- methods KW - Antineoplastic Agents, Phytogenic -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68334076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+oncology&rft.atitle=Individualized+pharmacotherapy+with+paclitaxel.&rft.au=Mielke%2C+Stephan&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2007-11-01&rft.volume=19&rft.issue=6&rft.spage=586&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+oncology&rft.issn=10408746&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Design and synthesis of paclitaxel conjugated with an ErbB2-recognizing peptide, EC-1. AN - 68333167; 17879382 AB - The selective delivery of therapeutic agents to receptors overexpressed in cancer cells without harming the rest of the body is a major challenge in clinical oncology today. In this study, we report the design and synthesis of paclitaxel (PTX) conjugated with an erbB2-recognizing peptide (EC-1). The cyclic peptide EC-1 specifically binds to the extracellular domain of ErbB2 and selectively inhibits proliferation of breast cancer cells overexpressing ErbB2. PTX is a potent antitumor agent commonly used in the treatment of advanced metastatic breast cancer, yet patients have to suffer some side effects caused by its systemic toxicity. The aim of our conjugate is to specifically deliver antitumor agent PTX to breast cancer cells that overexpress oncogenic ErbB2 with the purpose to reduce toxicity and enhance selective killing of cancer cells. In this study, a concise and efficient synthetic route for the preparation of the PTX-EC-1 conjugate has been developed in 6% overall yield. This synthetic approach provides a general method for conjugating a highly functionalized and disulfide-bridge containing cyclopeptide to Taxol or other antitumor agents. JF - Biopolymers AU - Li, Peng AU - Jiang, Sheng AU - Pero, Stephanie C AU - Oligino, Lyn AU - Krag, David N AU - Michejda, Christopher J AU - Roller, Peter P AD - Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Frederick, MD 21702, USA. Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 225 EP - 230 VL - 87 IS - 4 SN - 0006-3525, 0006-3525 KW - Peptides, Cyclic KW - 0 KW - paclitaxel-EC-1 conjugate KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Humans KW - Female KW - Breast Neoplasms -- drug therapy KW - Drug Delivery Systems KW - Receptor, ErbB-2 -- metabolism KW - Peptides, Cyclic -- metabolism KW - Breast Neoplasms -- metabolism KW - Paclitaxel -- therapeutic use KW - Drug Design KW - Paclitaxel -- metabolism KW - Peptides, Cyclic -- therapeutic use KW - Paclitaxel -- chemical synthesis KW - Paclitaxel -- analogs & derivatives KW - Peptides, Cyclic -- chemical synthesis KW - Peptides, Cyclic -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68333167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biopolymers&rft.atitle=Design+and+synthesis+of+paclitaxel+conjugated+with+an+ErbB2-recognizing+peptide%2C+EC-1.&rft.au=Li%2C+Peng%3BJiang%2C+Sheng%3BPero%2C+Stephanie+C%3BOligino%2C+Lyn%3BKrag%2C+David+N%3BMichejda%2C+Christopher+J%3BRoller%2C+Peter+P&rft.aulast=Li&rft.aufirst=Peng&rft.date=2007-11-01&rft.volume=87&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Biopolymers&rft.issn=00063525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leukemia following breast cancer: an international population-based study of 376,825 women. AN - 68328672; 17221155 AB - To quantify long-term temporal trends in the excess absolute risk (EAR) of secondary leukemia among breast cancer (BC) survivors, using multivariate analyses to evaluate the effects of subtype, age at BC diagnosis, attained age, and calendar year. We identified 376,825 1-year survivors of BC within 4 nationwide, population-based cancer registries in Sweden, Denmark, Finland, and Norway (1943-2001). Estimates of EAR (per 100,000 person-years) were modeled using Poisson regression methods and cumulative risks calculated using a competing risk model. A total of 687 non-chronic lymphocytic leukemias (EAR = 9.05; 95% confidence interval (CI) = 7.5-10.7) was reported. Significantly elevated risks were observed for the first time for chronic myeloid leukemia (CML) (EAR = 2.06; 95% CI = 1.3-2.9) and acute lymphoblastic leukemia (ALL) (EAR = 0.62; 95% CI = 0.2-1.1), in addition to acute myeloid leukemia (AML) (EAR = 5.00; 95% CI = 3.9-6.2). Excesses of CML, ALL, AML and all leukemias combined persisted over 25 years after BC diagnosis. For all leukemias, EAR decreased with increasing calendar year (P = 0.04) of BC diagnosis. Risk for all leukemia and AML by calendar year of BC diagnosis depended on age at diagnosis. For women diagnosed with BC after 1985, the 10-year cumulative risk of leukemia for those diagnosed before and after age 50 was small, 0.10% and 0.14%, respectively. Although secondary leukemia is a rare event, BC survivors experience statistically significant excesses for at least 25 years after diagnosis, including CML and ALL. Decreasing leukemia risks in recent calendar years likely reflect changes in treatment. JF - Breast cancer research and treatment AU - Howard, Regan A AU - Gilbert, Ethel S AU - Chen, Bingshu E AU - Hall, Per AU - Storm, Hans AU - Pukkala, Eero AU - Langmark, Froydis AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossa, Sophie D AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Executive Plaza South, Suite 7091, Bethesda, MD 20892, USA. reganho@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 359 EP - 368 VL - 105 IS - 3 SN - 0167-6806, 0167-6806 KW - Index Medicus KW - Leukemia, Radiation-Induced -- epidemiology KW - Aged, 80 and over KW - Risk Factors KW - Leukemia, Radiation-Induced -- complications KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Leukemia, Radiation-Induced -- diagnosis KW - Female KW - Neoplasms, Second Primary -- complications KW - Leukemia -- diagnosis KW - Neoplasms, Second Primary -- epidemiology KW - Breast Neoplasms -- diagnosis KW - Leukemia -- epidemiology KW - Neoplasms, Second Primary -- diagnosis KW - Leukemia -- complications KW - Breast Neoplasms -- epidemiology KW - Breast Neoplasms -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68328672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+and+treatment&rft.atitle=Leukemia+following+breast+cancer%3A+an+international+population-based+study+of+376%2C825+women.&rft.au=Howard%2C+Regan+A%3BGilbert%2C+Ethel+S%3BChen%2C+Bingshu+E%3BHall%2C+Per%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BLangmark%2C+Froydis%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossa%2C+Sophie+D%3BTravis%2C+Lois+B&rft.aulast=Howard&rft.aufirst=Regan&rft.date=2007-11-01&rft.volume=105&rft.issue=3&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+and+treatment&rft.issn=01676806&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-09 N1 - Date created - 2007-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users. AN - 68317120; 17619859 AB - A single 90-mg dose of the cannabinoid CB1 receptor antagonist rimonabant attenuates effects of smoked cannabis in humans. The objective of this study is to evaluate whether repeated daily 40-mg doses of rimonabant can attenuate effects of smoked cannabis to the same extent as a single higher (90 mg) dose. Forty-two male volunteers received one of three oral drug regimens in a randomized, double blind, parallel group design: (1) 40 mg rimonabant daily for 15 days, (2) placebo for 14 days, then 90 mg rimonabant on day 15, or (3) placebo for 15 days. All participants smoked an active or placebo cannabis cigarette 2 h after medication on days 8 and 15. Subjective effects were measured with visual analog scales and the marijuana-scale of the Addiction Research Center Inventory. Cannabis-induced tachycardia was significantly lower for the 40-mg group on day 8 and for the 40 and 90 mg rimonabant groups on day 15 as compared to placebo. The 40-mg dose significantly decreased peak subjective effects on day 8. Neither the 90-mg nor 40-mg doses significantly decreased peak subjective effects on day 15. Rimonabant treatment did not significantly affect Delta(9)-tetrahydrocannabinnol pharmacokinetics. Repeated lower daily rimonabant doses (40 mg) attenuated the acute physiological effects of smoked cannabis to a similar degree as a single 90-mg dose; repeated 40-mg doses attenuated subjective effects after 8 but not 15 days. JF - Psychopharmacology AU - Huestis, Marilyn A AU - Boyd, Susan J AU - Heishman, Stephen J AU - Preston, Kenzie L AU - Bonnet, Denis AU - Le Fur, Gerard AU - Gorelick, David A AD - Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA. mhuestis@intra.nida.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 505 EP - 515 VL - 194 IS - 4 SN - 0033-3158, 0033-3158 KW - Piperidines KW - 0 KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - Dronabinol KW - 7J8897W37S KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Tachycardia -- prevention & control KW - Administration, Oral KW - Drug Administration Schedule KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Sex Factors KW - Area Under Curve KW - Double-Blind Method KW - Dose-Response Relationship, Drug KW - Humans KW - Tachycardia -- physiopathology KW - Dronabinol -- blood KW - Heart Rate -- drug effects KW - Electrocardiography KW - Adult KW - Time Factors KW - Male KW - Pyrazoles -- administration & dosage KW - Piperidines -- therapeutic use KW - Marijuana Smoking -- psychology KW - Piperidines -- pharmacokinetics KW - Pyrazoles -- therapeutic use KW - Piperidines -- administration & dosage KW - Marijuana Abuse -- psychology KW - Marijuana Smoking -- physiopathology KW - Pyrazoles -- pharmacokinetics KW - Marijuana Smoking -- prevention & control KW - Marijuana Abuse -- physiopathology KW - Marijuana Abuse -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68317120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Single+and+multiple+doses+of+rimonabant+antagonize+acute+effects+of+smoked+cannabis+in+male+cannabis+users.&rft.au=Huestis%2C+Marilyn+A%3BBoyd%2C+Susan+J%3BHeishman%2C+Stephen+J%3BPreston%2C+Kenzie+L%3BBonnet%2C+Denis%3BLe+Fur%2C+Gerard%3BGorelick%2C+David+A&rft.aulast=Huestis&rft.aufirst=Marilyn&rft.date=2007-11-01&rft.volume=194&rft.issue=4&rft.spage=505&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-17 N1 - Date created - 2007-09-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Pharmacol. 2004 Oct 6;501(1-3):235-7 [15464083] Neuropsychopharmacology. 2004 Aug;29(8):1470-8 [15085091] Psychol Med. 1973 Nov;3(4):479-86 [4762224] NIDA Res Monogr. 1981 Feb;34:250-6 [6261133] Biomed Mass Spectrom. 1982 Jan;9(1):6-10 [6277407] Drug Alcohol Depend. 1985 Jun;15(3):229-38 [2992898] Nature. 1990 Aug 9;346(6284):561-4 [2165569] Clin Pharmacol Ther. 1992 Jul;52(1):31-41 [1320536] J Anal Toxicol. 1992 Sep-Oct;16(5):276-82 [1338215] FEBS Lett. 1994 Aug 22;350(2-3):240-4 [8070571] Neuroscience. 1994 Dec;63(3):637-52 [7898667] Annu Rev Pharmacol Toxicol. 1995;35:607-34 [7598509] FEBS Lett. 1995 Aug 7;369(2-3):177-82 [7544292] Eur J Biochem. 1995 Aug 15;232(1):54-61 [7556170] J Pharmacol Exp Ther. 1996 May;277(2):586-94 [8627535] Psychopharmacology (Berl). 1997 Jul;132(1):104-6 [9272766] Behav Pharmacol. 1998 Mar;9(2):179-81 [10065938] Psychopharmacology (Berl). 1999 Apr;143(3):315-7 [10353436] J Am Chem Soc. 1965 Jul 20;87:3273-5 [14324315] Alcohol Alcohol. 2005 Jan-Feb;40(1):2-14 [15550444] J Pharmacol Exp Ther. 2005 Mar;312(3):875-83 [15525797] Lancet. 2005 Apr 16-22;365(9468):1389-97 [15836887] Eur J Neurosci. 2005 Apr;21(8):2243-51 [15869521] N Engl J Med. 2005 Nov 17;353(20):2121-34 [16291982] JAMA. 2006 Feb 15;295(7):761-75 [16478899] Psychopharmacology (Berl). 2006 Apr;185(2):248-54 [16491428] Psychopharmacology (Berl). 2006 Oct;188(3):306-14 [16953389] Crit Rev Neurobiol. 1999;13(3):243-81 [10803637] Arch Gen Psychiatry. 2001 Apr;58(4):322-8 [11296091] Nature. 2001 Apr 12;410(6830):822-5 [11298451] Eur J Pharmacol. 2001 May 11;419(2-3):207-14 [11426843] Nat Med. 2001 Oct;7(10):1151-4 [11590440] J Anal Toxicol. 2001 Oct;25(7):531-7 [11599596] Br J Pharmacol. 2001 Nov;134(6):1151-4 [11704633] J Neurosci Res. 2002 May 15;68(4):449-53 [11992471] Pharmacol Ther. 2002 Aug;95(2):127-35 [12182960] Behav Pharmacol. 2002 Sep;13(5-6):451-63 [12394421] J Neurosci. 2002 Nov 1;22(21):9612-7 [12417686] Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R345-53 [12399252] Am J Physiol Regul Integr Comp Physiol. 2003 Feb;284(2):R343-4 [12529283] Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1393-8 [12538878] Mol Pharmacol. 2003 Apr;63(4):908-14 [12644592] J Biol Chem. 2003 Jun 27;278(26):23731-7 [12690115] Psychopharmacology (Berl). 2004 Feb;172(1):25-30 [14991224] Int J Obes Relat Metab Disord. 2004 Apr;28(4):640-8 [14770190] J Leukoc Biol. 2004 May;75(5):884-92 [14966196] Neuro Endocrinol Lett. 2004 Feb-Apr;25(1-2):14-23 [15159677] Eur J Heart Fail. 2004 Jun;6(4):501-8 [15182777] Eur J Pharmacol. 2004 Jun 28;494(2-3):221-4 [15212978] Neuroreport. 2004 Sep 15;15(13):2139-43 [15486497] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Social Influences on Adolescent Substance Use AN - 57251295; 200810656 AB - Objectives: To assess the overtime relationships between adolescent and peer substance use and parenting practices. Methods: Five times from sixth to ninth grade, students (n=2453) in 7 middle schools reported smoking, drinking, and marijuana use; the number of substance-using friends; and parent practices. Relationships were assessed using latent growth curve modeling. Results: Adolescent substance use predicted the growth in substance-using friends, and substance-using friends predicted adolescent use, except for smoking. The negative over-time relationship between parenting practices and adolescent substance use was mediated by the growth in the number of substance-using friends. Conclusions: The results are consistent with both selection and socialization effects and provide evidence of the protective effects of positive parenting practices. Adapted from the source document. JF - American Journal of Health Behavior AU - Simons-Morton, Bruce AD - Prevention Research Branch, Division of Statistics, Epidemiology, and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd 7B13M. Bethesda, MD 20892-7510 mortonb@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 672 EP - 684 PB - PNG Publications, Star City WV VL - 31 IS - 6 SN - 1087-3244, 1087-3244 KW - latent growth curve modeling, mediation, peer influence, parenting, selection, socialization KW - Smoking KW - Parenting KW - Social influence KW - Adolescents KW - Substance abuse KW - Middle schools KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57251295?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=Social+Influences+on+Adolescent+Substance+Use&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2007-11-01&rft.volume=31&rft.issue=6&rft.spage=672&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Social influence; Substance abuse; Parenting; Smoking; Adolescents; Middle schools ER - TY - JOUR T1 - Questionnaire Design from a Cross-Cultural Perspective: An Empirical Investigation of Koreans and Non-Koreans AN - 57240531; 200813042 AB - A persistent challenge to self-report data across racial, ethnic, or cultural groups is the inherent difficulty of attaining cross-cultural comparability of key measures. The current research study investigated the cross-cultural functioning of health-survey questions presented to four groups: (1) Koreans who were monolingual in Korean; (2) non-Korean native speakers of English; (3) bilingual Koreans interviewed in English, and (4) bilingual Koreans interviewed in Korean. This design allowed us to include those likely to be medically underserved, and to assess both linguistic and cultural barriers to collecting health survey data. A total of 36 cognitive interviews were conducted to identify (a) translation problems; (b) problems of cultural adaptation that impede cross-cultural comparability; and (c) generic problems of questionnaire design that affect all groups. An important category of problems was identified that appeared to result from the interaction of respondent and question characteristics. Such problems can best be assessed through explicit consideration of the socio-cultural backgrounds of survey respondents, as opposed to the more usual focus on details of item translation and wording. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Willis, Gordon AU - Zahnd, Elaine AD - National Cancer Institute, Applied Research Program, 6130 Executive Blvd., MSC 7344, EPN 4005, Bethesda, MD 20892-7344 Tel: (301) 594-6652 willisg@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 197 EP - 217 PB - John Hopkins University Press, Baltimore MD VL - 18 IS - 4 supplement SN - 1049-2089, 1049-2089 KW - Race/ethnicity, Korean, cross-cultural comparability, cognitive interviews, language, linguistic barriers, cultural adaptation KW - Selfreport measures KW - Korean language KW - Crosscultural aspects KW - Crosscultural research KW - Health information KW - Ethnic groups KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57240531?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Questionnaire+Design+from+a+Cross-Cultural+Perspective%3A+An+Empirical+Investigation+of+Koreans+and+Non-Koreans&rft.au=Willis%2C+Gordon%3BZahnd%2C+Elaine&rft.aulast=Willis&rft.aufirst=Gordon&rft.date=2007-11-01&rft.volume=18&rft.issue=4+supplement&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Crosscultural research; Ethnic groups; Selfreport measures; Crosscultural aspects; Korean language; Health information ER - TY - JOUR T1 - Employment Characteristics and Socioeconomic Factors Associated with Disparities in Smoking Abstinence and Former Smoking Among U.S. Workers AN - 57236935; 200811459 AB - Purpose. This study examines the associations among employment and socioeconomic factors and the outcomes, current smoking, cigarette abstinence and former smoking among adult U.S. workers ages 18-64 (n=288, 813). Methods. Multivariate logistic regression was used to examine the associations among the variables using cross-sectional data from the 1998-1999 and 2001-2002 Tobacco Use Supplements to the Current Population Survey. Results. Lower odds of current smoking was observed among part-time workers compared to those working variable hours and multiple job holders compared to persons holding one job. The self-employed, part-time workers and multiple job holders had higher odds of former smoking than comparison groups. Employment factors were not associated with short-term abstinence or 12-month abstinence from smoking, but income, education, marital status, and duration of smoking were associated with 12-month abstinence. Conclusions. These data suggest that while employment factors are associated with current and former smoking, socioeconomic factors are associated with long-term quitting. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Fagan, Pebbles AU - Shavers, Vickie L AU - Lawrence, Deirdre AU - Gibson, James Todd AU - O'Connell, Mary E AD - Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4042, 6130 Executive Blvd., MSC 7337, Bethesda, MD 20892-7337 Tel: (301) 496-8584 faganp@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 52 EP - 72 PB - John Hopkins University Press, Baltimore MD VL - 18 IS - 4 supplement SN - 1049-2089, 1049-2089 KW - socioeconomic, self-employment, part-time work, multiple job holders, smoking, quitting KW - Abstinence KW - Working hours KW - Smoking KW - Socioeconomic factors KW - Ex-smokers KW - Employment status KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57236935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=Employment+Characteristics+and+Socioeconomic+Factors+Associated+with+Disparities+in+Smoking+Abstinence+and+Former+Smoking+Among+U.S.+Workers&rft.au=Fagan%2C+Pebbles%3BShavers%2C+Vickie+L%3BLawrence%2C+Deirdre%3BGibson%2C+James+Todd%3BO%27Connell%2C+Mary+E&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-11-01&rft.volume=18&rft.issue=4+supplement&rft.spage=52&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Ex-smokers; Smoking; Socioeconomic factors; Employment status; Abstinence; Working hours ER - TY - JOUR T1 - Translating research into action: a case study on trans fatty acid research and nutrition policy in Costa Rica AN - 57234307; 200811266 AB - Mounting epidemiologic evidence worldwide has fostered policy regulation of industrially made trans fatty acids (TFA) in several developed countries. Despite country-specific evidence about the effects of the on cardiovascular disease in Costa Rica, policy regulation has yet to occur. This qualitative study uses a conceptual framework to identify factors that may impede or promote the process of translation of scientific evidence about TFA into policy in the specific context of Costa Rica. We used single case-study methodology to integrate two sources of data: review of relevant internal documents and in-depth, semi-structured interviews with 21 respondents purposively sampled from three sectors: the cooking oil and food industries, research and academia, and government entities. Content analysis, guided by a conceptual framework of research utilization, revealed 68 emergent themes divided across four categories of analysis. In brief, study participants perceived the political context suitable for discussing policies related to healthy fats. Nevertheless, TFA regulation was not part of the Costa Rican political agenda. Barriers perceived by respondents that impede knowledge translation included: (1) lack of awareness of in-country scientific studies on health effects of TFA; (2) lack of consensus or information about policy options (nutrition labelling, dietary guidelines, legislative mandates); (3) perceived distrust and disparate attitudes between sectors, believed by study participants to result in (4) limited collaboration across sectors. Commissioned task forces and other mechanisms to foster research engagement and facilitate sustained interaction and systematic collaboration among government, food industry and researcher sectors appear crucial in the consideration and adoption of nutrition policy in Costa Rica and other emerging economies. Adapted from the source document. JF - Health Policy and Planning AU - Colon-Ramos, Uriyoan AU - Lindsay, Ana C AU - Monge-Rojas, Rafael AU - Greaney, Mary L AU - Campos, Hannia AU - Peterson, Karen E AD - Health Promotion Research Branch, Behavioral Research Program, National Cancer Institute, 6130 Executive Blvd MSC 7335, Bethesda, MD 20892-7335, USA Tel: +1 301 657 2101, Fax: +1 301 480 2087 Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 363 EP - 374 PB - Oxford University Press, Oxford UK VL - 22 IS - 6 SN - 0268-1080, 0268-1080 KW - Health policy, nutrition, Costa Rica, developing countries, trans fatty acids KW - Costa Rica KW - Fatty acids KW - Health policy KW - Cardiovascular diseases KW - Nutrition KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57234307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Policy+and+Planning&rft.atitle=Translating+research+into+action%3A+a+case+study+on+trans+fatty+acid+research+and+nutrition+policy+in+Costa+Rica&rft.au=Colon-Ramos%2C+Uriyoan%3BLindsay%2C+Ana+C%3BMonge-Rojas%2C+Rafael%3BGreaney%2C+Mary+L%3BCampos%2C+Hannia%3BPeterson%2C+Karen+E&rft.aulast=Colon-Ramos&rft.aufirst=Uriyoan&rft.date=2007-11-01&rft.volume=22&rft.issue=6&rft.spage=363&rft.isbn=&rft.btitle=&rft.title=Health+Policy+and+Planning&rft.issn=02681080&rft_id=info:doi/10.1093%2Fheapol%2Fczm030 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-06-11 N1 - Last updated - 2016-09-27 N1 - CODEN - HPOPEV N1 - SubjectsTermNotLitGenreText - Cardiovascular diseases; Costa Rica; Health policy; Nutrition; Fatty acids DO - http://dx.doi.org/10.1093/heapol/czm030 ER - TY - JOUR T1 - Perceptions of Americans and the Iraq Invasion: Implications for Understanding National Character Stereotypes AN - 57231745; 200809432 AB - This study examines perceptions of the 'typical American' from 49 cultures around the world. Contrary to the ethnocentric bias hypothesis, a strong agreement was found between in-group and out-group ratings on the American profile (assertive, open-minded, but antagonistic). In fact, Americans had a somewhat less desirable view of Americans than did others. Within cultures, in-group ratings were not systematically more favorable than out-group ratings. The Iraq invasion had a slight negative effect on perceptions of the typical American, but people around the world seem to draw a clear distinction between U.S. foreign policy and the character of the American people. National character stereotypes appear to have a variety of sources and to be perpetuated by both cognitive mechanisms and sociocultural forces. [Reprinted by permission of Sage Publications Inc., copyright 2007.] JF - Journal of Cross-Cultural Psychology AU - Terracciano, Antonio AU - McCrae, Robert R AD - National Institute on Aging, National Institutes of Health, Department of Health and Human Services terraccianoa@grc.nia.nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 695 EP - 710 PB - Sage Publications, Thousand Oaks VL - 38 IS - 6 SN - 0022-0221, 0022-0221 KW - Foreign policy KW - American people KW - Perceptions KW - Wars KW - National identity KW - Stereotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57231745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cross-Cultural+Psychology&rft.atitle=Perceptions+of+Americans+and+the+Iraq+Invasion%3A+Implications+for+Understanding+National+Character+Stereotypes&rft.au=Terracciano%2C+Antonio%3BMcCrae%2C+Robert+R&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2007-11-01&rft.volume=38&rft.issue=6&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cross-Cultural+Psychology&rft.issn=00220221&rft_id=info:doi/10.1177%2F0022022107308586 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JCPGB5 N1 - SubjectsTermNotLitGenreText - National identity; Wars; Perceptions; American people; Stereotypes; Foreign policy DO - http://dx.doi.org/10.1177/0022022107308586 ER - TY - JOUR T1 - An Examination of Community Members', Researchers' and Health Professionals' Perceptions of Barriers to Minority Participation in Medical Research: An Application of Concept Mapping AN - 57225385; 200808065 AB - Objective. Some of the most promising medical treatments are currently being developed and used in clinical trials. In the US, rates of chronic disease among racial/ethnic minorities are disproportionately high. Unfortunately, the rates of minority participation in medical research are low, and the reasons are unclear. This study seeks to contribute to the body of knowledge that is currently available relating to the specific barriers to racial/ethnic minority participation in medical research through the conceptualization and measurement of these barriers. Design. Study participants included a convenience sample obtained from the National Cancer Institute's Special Populations Networks, and consisted of practitioners, researchers and community members who specialize in research related to the treatment and prevention of cancer. A structured form of concept mapping (Trochim 1989) was the methodology used in this study. The concept mapping process has three specific phases: (1) project planning - development of project focus statements and sample selection (2) idea generation and structuring and (3) analysis and interpretation. This method is analogous to a more formalized and structured focus group approach, and involved the gathering of 149 ideas and the sorting of 70 statements. Comparisons across participant demographics were conducted and are presented in the form of pattern matches. Results. The findings of this study suggest that there are two specific areas where barriers to minority participation may be addressed. The first area is the research system, specifically, the manner in which research studies are designed and implemented, including referral, recruitment and retention of racial/ethnic minorities. The data suggest that recruitment and retention will be aided by addressing patient concerns regarding the research process, and assuaging fears about clinical trials. The second area pertains to minority perceptions of the research process based on history and personal experiences. Conclusion. There appears to be a difference in the barriers to participation as defined by community members themselves, and health professionals' perceptions of these barriers. Increased inclusion of minorities in the design, management, and implementation of medical research studies would help mitigate negative perceptions of the research process, and serve to increase participation among racial/ethnic minorities. Adapted from the source document. JF - Ethnicity & Health AU - Robinson, Jamuir M AU - Trochim, William M K AD - Division of Cancer Prevention and Office of Education and Special Initiatives, National Cancer Institute, National Institutes of Health Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 521 EP - 539 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 5 SN - 1355-7858, 1355-7858 KW - Medical research KW - Research design KW - Minority groups KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57225385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Health&rft.atitle=An+Examination+of+Community+Members%27%2C+Researchers%27+and+Health+Professionals%27+Perceptions+of+Barriers+to+Minority+Participation+in+Medical+Research%3A+An+Application+of+Concept+Mapping&rft.au=Robinson%2C+Jamuir+M%3BTrochim%2C+William+M+K&rft.aulast=Robinson&rft.aufirst=Jamuir&rft.date=2007-11-01&rft.volume=12&rft.issue=5&rft.spage=521&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557850701616987 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ETHEFR N1 - SubjectsTermNotLitGenreText - Medical research; Minority groups; Research design DO - http://dx.doi.org/10.1080/13557850701616987 ER - TY - JOUR T1 - Fetal heart rate and variability: stability and prediction to developmental outcomes in early childhood AN - 36785879; 3481404 AB - Stability in cardiac indicators before birth and their utility in predicting variation in postnatal development were examined. Fetal heart rate and variability were measured longitudinally from 20 through 38 weeks gestation (n = 137) and again at age 2 (n = 79). Significant within-individual stability during the prenatal period and into childhood was demonstrated. Fetal heart rate variability at or after 28 weeks gestation and steeper developmental trajectories were significantly associated with mental and psychomotor development at 2 years (n = 82) and language ability at 2.5 years (n = 61). These data suggest that the foundations of individual differences in autonomic control originate during gestation and the developmental momentum of the fetal period continues after birth. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - DiPietro, Janet A AU - Bornstein, Marc H AU - Hahn, Chun-Shin AU - Costigan, Kathleen AU - Achy-Brou, Aristide AD - Johns Hopkins University ; National Institutes of Health ; Johns Hopkins Medical Institutions Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1788 EP - 1798 VL - 78 IS - 6 SN - 0009-3920, 0009-3920 KW - Anthropology KW - Birth KW - Human development KW - Childhood KW - Foetus KW - Well-being KW - Reproductive health KW - Reproductive technology KW - Developmental psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36785879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Fetal+heart+rate+and+variability%3A+stability+and+prediction+to+developmental+outcomes+in+early+childhood&rft.au=DiPietro%2C+Janet+A%3BBornstein%2C+Marc+H%3BHahn%2C+Chun-Shin%3BCostigan%2C+Kathleen%3BAchy-Brou%2C+Aristide&rft.aulast=DiPietro&rft.aufirst=Janet&rft.date=2007-11-01&rft.volume=78&rft.issue=6&rft.spage=1788&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 3518 10404; 2211 652 5676 646 6091 2212; 10895 11574; 10893 5772; 5080 11574; 13530 13521; 1635 11574; 6075 3483 ER - TY - JOUR T1 - Measurement of cerebral perfusion territories using arterial spin labelling AN - 21066658; 8632255 AB - The ability to assess the perfusion territories of major cerebral arteries can be a valuable asset to the diagnosis of a number of cerebrovascular diseases. Recently, several arterial spin labeling (ASL) techniques have been proposed for determining the cerebral perfusion territories of individual arteries by three different approaches: (1) using a dedicated labeling radio frequency (RF) coil; (2) applying selective inversion of spatially confined areas; (3) employing multidimensional RF pulses. Methods that use a separate labeling RF coil have high signal-to-noise ratio (SNR), low RF power deposition, and unrestricted three-dimensional coverage, but are mostly limited to separation of the left and right circulation, and do require extra hardware, which may limit their implementation in clinical systems. Alternatively, methods that utilize selective inversion have higher flexibility of implementation and higher arterial selectivity, but suffer from imaging artifacts resulting from interference between the labeling slab and the volume of interest. The goal of this review is to provide the reader with a critical survey of the different ASL approaches proposed to date for determining cerebral perfusion territories, by discussing the relative advantages and disadvantages of each technique, so as to serve as a guide for future refinement of this promising methodology. JF - NMR in Biomedicine AU - Paiva, Fernando F AU - Tannus, Alberto AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1065, USA, SilvaA@ninds.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 633 EP - 642 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 20 IS - 7 SN - 0952-3480, 0952-3480 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Perfusion KW - Cerebrovascular diseases KW - Arteries KW - Territory KW - imaging KW - Spin labelling KW - Inversion KW - Reviews KW - N.M.R. KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21066658?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+Biomedicine&rft.atitle=Measurement+of+cerebral+perfusion+territories+using+arterial+spin+labelling&rft.au=Paiva%2C+Fernando+F%3BTannus%2C+Alberto%3BSilva%2C+Afonso+C&rft.aulast=Paiva&rft.aufirst=Fernando&rft.date=2007-11-01&rft.volume=20&rft.issue=7&rft.spage=633&rft.isbn=&rft.btitle=&rft.title=NMR+in+Biomedicine&rft.issn=09523480&rft_id=info:doi/10.1002%2Fnbm.1177 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Territory; Perfusion; Inversion; Arteries; imaging; N.M.R.; Reviews; Cerebrovascular diseases; Spin labelling DO - http://dx.doi.org/10.1002/nbm.1177 ER - TY - JOUR T1 - Minimizing RF heating of conducting wires in MRI AN - 20854719; 8368624 AB - Performing interventions using long conducting wires in MRI introduces the risk of focal RF heating at the wire tip. Comprehensive EM simulations are combined with carefully measured experimental data to show that method-of-moments EM field modeling coupled with heat transfer modeling can adequately predict RF heating with wires partially inserted into the patient-mimicking phantom. The effects of total wire length, inserted length, wire position in the phantom, phantom position in the scanner, and phantom size are examined. Increasing phantom size can shift a wire's length of maximum tip heating from about a half wave toward a quarter wave. In any event, with wires parallel to the scanner bore, wire tip heating is minimized by keeping the patient and wires as close as possible to the central axis of the scanner bore. At 1.5T, heating is minimized if bare wires are shorter than 0.6 m or between 2.4 m and 3.0 m. Heating is further minimized if wire insertion into phantoms equivalent to most aqueous soft tissues is less than 13 cm or greater than 40 cm (longer for fatty tissues, bone, and lung). The methods demonstrated can be used to estimate the absolute amount of heating in order to set RF power safety thresholds. Magn Reson Med 58:1028-1034, 2007. JF - Magnetic Resonance in Medicine AU - Yeung, Christopher J AU - Karmarkar, Parag AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, National Heart, Lung & Blood Institute, Division of Intramural Research, National Institutes of Health, Bethesda, Maryland, mcveighe@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1028 EP - 1034 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 58 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Lung KW - Magnetic resonance imaging KW - N.M.R. KW - Waves KW - Soft tissues KW - Heat transfer KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20854719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Minimizing+RF+heating+of+conducting+wires+in+MRI&rft.au=Yeung%2C+Christopher+J%3BKarmarkar%2C+Parag%3BMcVeigh%2C+Elliot+R&rft.aulast=Yeung&rft.aufirst=Christopher&rft.date=2007-11-01&rft.volume=58&rft.issue=5&rft.spage=1028&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21410 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Waves; Soft tissues; Heat transfer; N.M.R.; Data processing; Lung DO - http://dx.doi.org/10.1002/mrm.21410 ER - TY - JOUR T1 - Molecular Pathways and Related Target Therapies in Liver Carcinoma AN - 20843248; 7655065 AB - Hepatocellular carcinoma (HCC) is a frequent neoplasia which still misses a therapeutical gold standard. Recently, new acquisitions in cancerogenesis process evidenced the genetic and epigenetic alterations of genes involved in the different metabolic pathways of liver cancer suggesting that antibodies, small molecules, demethylating agents, etc. specifically acting against molecular target can be utilized alone or in combination in clinical practice. The main altered targets are: cell membrane receptors, in particular tyrosine kinase receptors, factors involved in cell signalling, specifically Wnt/ beta -catenin, Ras/Raf/MEK/ERK and PI3K/Akt/mTOR pathways, proteins linked to cell cycle regulation pathway (i.e. p53, p16/INK4, cyclin/cdk complex) or in invasiveness (EMT, TGFbeta) and proteins involved in DNA metabolism. Genetic or epigenetic changes in these molecules have been used in preclinical settings and, some of them also in clinical trials of phas IIE an IIID. This scenario opens new avenues for the prevention and the treatment of HCC. In the present review the main metabolic pathways and molecular alterations have been described together with recent advances in molecular and gene therapy. JF - Current Pharmaceutical Design AU - Tommasi, S AU - Pinto, R AU - Pilato, B AU - Paradiso, A AD - Clinical Experimental Oncology Laboratory, National Cancer Institute 'Giovanni Paolo II', v. Hahneman 10, 70126 Bari, Italy. Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 3279 EP - 3287 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 13 IS - 32 SN - 1381-6128, 1381-6128 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Hepatocarcinoma KW - target therapies KW - molecular alterations KW - cellular pathways KW - Invasiveness KW - Wnt protein KW - Liver cancer KW - Cell cycle KW - Clinical trials KW - Neoplasia KW - Extracellular signal-regulated kinase KW - 1-Phosphatidylinositol 3-kinase KW - Cell membranes KW - Cyclin-dependent kinase KW - epigenetics KW - Metabolic pathways KW - AKT protein KW - Cyclins KW - Hepatocellular carcinoma KW - INK4 protein KW - Ras protein KW - cyclin-dependent kinase inhibitors KW - Protein-tyrosine kinase receptors KW - Carcinoma KW - p53 protein KW - Antibodies KW - Raf protein KW - catenin KW - Reviews KW - DNA KW - Signal transduction KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20843248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Pharmaceutical+Design&rft.atitle=Molecular+Pathways+and+Related+Target+Therapies+in+Liver+Carcinoma&rft.au=Tommasi%2C+S%3BPinto%2C+R%3BPilato%2C+B%3BParadiso%2C+A&rft.aulast=Tommasi&rft.aufirst=S&rft.date=2007-11-01&rft.volume=13&rft.issue=32&rft.spage=3279&rft.isbn=&rft.btitle=&rft.title=Current+Pharmaceutical+Design&rft.issn=13816128&rft_id=info:doi/10.2174%2F138161207782360663 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Invasiveness; Wnt protein; Liver cancer; Cell cycle; Clinical trials; Neoplasia; Extracellular signal-regulated kinase; 1-Phosphatidylinositol 3-kinase; Cell membranes; Cyclin-dependent kinase; epigenetics; AKT protein; Metabolic pathways; INK4 protein; Hepatocellular carcinoma; Cyclins; Ras protein; cyclin-dependent kinase inhibitors; Protein-tyrosine kinase receptors; p53 protein; Carcinoma; Raf protein; Antibodies; catenin; Reviews; DNA; Signal transduction DO - http://dx.doi.org/10.2174/138161207782360663 ER - TY - JOUR T1 - Uncertainties in individual doses in a case-control study of thyroid cancer after the Chernobyl accident AN - 20782441; 8304881 AB - Individual radiation doses to the thyroid were reconstructed for 2239 subjects of a case-control study of thyroid cancer among young people that was carried out in regions of Belarus and Russia contaminated by radioactive fallout from the Chernobyl accident. Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7. JF - Radiation Protection Dosimetry AU - Drozdovitch, V AU - Maceika, E AU - Khrouch, V AU - Zvonova, I AU - Vlasov, O AU - Bouville, A AU - Cardis, E AD - International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. Institute of Physics, Vilnius, Lithuania. State Research Centre-Institute of Biophysics, Moscow, Russia. Institute of Radiation Hygiene, St Petersburg, Russia. Medical Radiological Research Center, Obninsk, Russia. DHHS, NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics, EPS 7094, Bethesda, MD 20892, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 540 EP - 543 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 127 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Pollution Abstracts; Health & Safety Science Abstracts KW - Belarus KW - Monte Carlo simulation KW - Nuclear power plants KW - Ukraine, Chernobyl KW - Radioactive fallout KW - Thyroid KW - Russia KW - Cancer KW - H 8000:Radiation Safety/Electrical Safety KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20782441?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Uncertainties+in+individual+doses+in+a+case-control+study+of+thyroid+cancer+after+the+Chernobyl+accident&rft.au=Drozdovitch%2C+V%3BMaceika%2C+E%3BKhrouch%2C+V%3BZvonova%2C+I%3BVlasov%2C+O%3BBouville%2C+A%3BCardis%2C+E&rft.aulast=Drozdovitch&rft.aufirst=V&rft.date=2007-11-01&rft.volume=127&rft.issue=1-4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Monte Carlo simulation; Nuclear power plants; Radioactive fallout; Thyroid; Cancer; Belarus; Ukraine, Chernobyl; Russia ER - TY - JOUR T1 - Sun exposure, vitamin D receptor gene polymorphisms and risk of non-Hodgkin lymphoma AN - 20726195; 7617853 AB - Objective: Recent findings suggest that ultraviolet (UV) radiation exposure may reduce risk of developing non-Hodgkin lymphoma (NHL), but the biologic basis for this relationship remains unclear. We analyzed data from our US population-based case-control study of NHL to investigate whether our previously reported inverse association with sun exposure was dependent upon variants in the vitamin D receptor gene (IVS10 + 283G > A (BsmI), Ex11 + 32T > C (TaqI)), and genes linked to UV-induced immune modulation (IL4, IL10, IL12A, IL12B, TNF). Methods: UV exposure data was collected from an in-person interview with 551 cases and 462 controls. We calculated odds ratios (OR) and 95% confidence intervals (CI) for sun exposure measures for joint variant-exposure effects. Results: The association with NHL risk for time in the midday sun within the last decade was dependent upon Ex11 + 32 T > C genotype. Compared to TT carriers who reported A is correlated with Ex11 + 32T > C in our population (r super(2) = 0.95), results were equivalent for those with the IVS10 + 283 AA genotype. No evidence of interaction with cytokine gene variants was observed. Conclusions: Our results suggest that the inverse association between UV exposure and NHL risk may be mediated by the vitamin D pathway. Further investigation of this finding in other studies is warranted. JF - Cancer Causes & Control AU - Purdue, Mark P AU - Hartge, Patricia AU - Davis, Scott AU - Cerhan, James R AU - Colt, Joanne S AU - Cozen, Wendy AU - Severson, Richard K AU - Li, Yan AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Wang, Sophia S AD - National Cancer Institute, 6120 Executive Blvd, EPS 8009, Rockville, MD, 20892, USA, purduem@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 989 EP - 999 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 18 IS - 9 SN - 0957-5243, 0957-5243 KW - Genetics Abstracts; Risk Abstracts; Immunology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Interleukin 4 KW - Gene polymorphism KW - Tumor necrosis factor KW - Interleukin 1 KW - Genotypes KW - Immunomodulation KW - sun KW - Interleukin 10 KW - risk reduction KW - vitamins KW - U.V. radiation KW - Risk factors KW - Ultraviolet radiation KW - Sun KW - Cytokines KW - Lymphoma KW - Data processing KW - Cancer KW - Joints KW - Vitamin D receptors KW - lymphoma KW - G 07720:Immunogenetics KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Sun+exposure%2C+vitamin+D+receptor+gene+polymorphisms+and+risk+of+non-Hodgkin+lymphoma&rft.au=Purdue%2C+Mark+P%3BHartge%2C+Patricia%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BColt%2C+Joanne+S%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K%3BLi%2C+Yan%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-11-01&rft.volume=18&rft.issue=9&rft.spage=989&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-007-9039-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Interleukin 4; Data processing; Tumor necrosis factor; Gene polymorphism; Interleukin 1; Genotypes; Immunomodulation; Interleukin 10; Joints; U.V. radiation; Risk factors; Sun; Vitamin D receptors; Cytokines; Lymphoma; non-Hodgkin's lymphoma; risk reduction; vitamins; Ultraviolet radiation; lymphoma; Cancer; sun DO - http://dx.doi.org/10.1007/s10552-007-9039-z ER - TY - JOUR T1 - Contribution of internal exposures to the radiological consequences of the Chernobyl accident AN - 20725262; 8304870 AB - The main pathways leading to exposure of members of the general public due to the Chernobyl accident were external exposure from radionuclides deposited on the ground and ingestion of contaminated terrestrial food products. The collective dose to the thyroid was nearly 1.5 million man Gy in Belarus, Russia and Ukraine with nearly half received by children and adolescents. The collective effective dose received in 1986-2005 by similar to five million residents living in the affected areas of the three countries was similar to 50 000 man Sv with similar to 40% from ingestion. That contribution might have been larger if countermeasures had not been applied. The main radionuclide contributing to both external and internal effective dose is super(137)Cs with smaller contributions of super(134)Cs and super(90)Sr and negligible contribution of transuranic elements. The major demonstrated radiation-caused health effect of the Chernobyl accident has been an elevated incidence of thyroid cancer in children. JF - Radiation Protection Dosimetry AU - Balonov, MI AU - Anspaugh, L R AU - Bouville, A AU - Likhtarev, IA AD - International Atomic Energy Agency, Wagramer Strasse, 5, PO Box 100, Vienna, A-1400, Austria. University of Utah, PO Box 777777, Henderson, NV 89077, USA. National Cancer Institute, Bethesda, MD 20892, USA. Ukrainian Centre for Radiation Medicine, Melnikova Street, 53, 04050 Kyiv, Ukraine Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 491 EP - 496 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 127 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Pollution Abstracts KW - Belarus KW - Ukraine, Chernobyl KW - Ukraine KW - Thyroid KW - Ingestion KW - Children KW - Transuranics KW - Cancer KW - Nuclear power plants KW - Radioactive fallout KW - Radioisotopes KW - Strontium KW - Russia KW - Adolescents KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725262?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Protection+Dosimetry&rft.atitle=Contribution+of+internal+exposures+to+the+radiological+consequences+of+the+Chernobyl+accident&rft.au=Balonov%2C+MI%3BAnspaugh%2C+L+R%3BBouville%2C+A%3BLikhtarev%2C+IA&rft.aulast=Balonov&rft.aufirst=MI&rft.date=2007-11-01&rft.volume=127&rft.issue=1-4&rft.spage=491&rft.isbn=&rft.btitle=&rft.title=Radiation+Protection+Dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Nuclear power plants; Radioactive fallout; Thyroid; Radioisotopes; Strontium; Transuranics; Children; Ingestion; Adolescents; Cancer; Belarus; Ukraine, Chernobyl; Ukraine; Russia ER - TY - JOUR T1 - Acute oral toxicity of Yersinia pseudotuberculosis to fleas: implications for the evolution of vector-borne transmission of plague AN - 20677394; 7979827 AB - Yersinia pestis diverged from Yersinia pseudotuberculosis less than or equal to 20 000 years ago, during which time it evolved to be transmitted by fleas. In comparing the ability of these closely related species to infect the rat flea Xenopsylla cheopis, we found that Y. pseudotuberculosis, unlike Y. pestis, is orally toxic to fleas. Fleas showed signs of acute toxicity, including diarrhoea, immediately after feeding on blood containing Y. pseudotuberculosis in response to protein toxin(s) produced by the bacteria. Adherence of Y. pseudotuberculosis to the midgut and large intracellular vacuoles in midgut epithelial cells were detected during the first 24 h after infection. The insect pathogen Photorhabdus luminescens and its TcdA1 and TcdB1-TccC1 insecticidal toxin complexes were similarly toxic to fleas, implicating the toxin complex (tc) genes also present in Yersinia species. However, the Y. pestis and Y. pseudotuberculosis TcaAB and TcaC-TccC proteins were non-toxic to fleas, and Y. pseudotuberculosis mutants deleted of tc genes retained acute toxicity. Our results indicate that loss of one or more insect gut toxins was a critical step in the recent evolution of flea-borne transmission in the genus Yersinia. Changes in the tc insecticidal genes do not appear to have been responsible, but may have had other effects on Yersinia-flea interactions. JF - Cellular Microbiology AU - Erickson, David L AU - Waterfield, Nicholas R AU - Vadyvaloo, Viveka AU - Long, Daniel AU - Fischer, Elizabeth R AU - ffrench-Constant, Richard AU - Hinnebusch, BJoseph AD - Laboratory of Zoonotic Pathogens,, jhinnebusch@niaid.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2658 EP - 2666 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 9 IS - 11 SN - 1462-5814, 1462-5814 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology KW - Feeding KW - Epithelial cells KW - Diarrhea KW - Yersinia pestis KW - Yersinia pseudotuberculosis KW - Pathogens KW - Acute toxicity KW - Infection KW - Toxins KW - Disease transmission KW - Xenopsylla cheopis KW - Blood KW - Digestive tract KW - Photorhabdus luminescens KW - Vacuoles KW - Plague KW - Midgut KW - Pseudotuberculosis KW - Evolution KW - J 02400:Human Diseases KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20677394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+Microbiology&rft.atitle=Acute+oral+toxicity+of+Yersinia+pseudotuberculosis+to+fleas%3A+implications+for+the+evolution+of+vector-borne+transmission+of+plague&rft.au=Erickson%2C+David+L%3BWaterfield%2C+Nicholas+R%3BVadyvaloo%2C+Viveka%3BLong%2C+Daniel%3BFischer%2C+Elizabeth+R%3Bffrench-Constant%2C+Richard%3BHinnebusch%2C+BJoseph&rft.aulast=Erickson&rft.aufirst=David&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=2658&rft.isbn=&rft.btitle=&rft.title=Cellular+Microbiology&rft.issn=14625814&rft_id=info:doi/10.1111%2Fj.1462-5822.2007.00986.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Feeding; Diarrhea; Acute toxicity; Pathogens; Infection; Toxins; Disease transmission; Blood; Digestive tract; Vacuoles; Midgut; Plague; Pseudotuberculosis; Evolution; Xenopsylla cheopis; Photorhabdus luminescens; Yersinia pseudotuberculosis; Yersinia pestis DO - http://dx.doi.org/10.1111/j.1462-5822.2007.00986.x ER - TY - JOUR T1 - IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial AN - 20649495; 8079747 AB - IGF-1 and IGFBP-3 may influence risk of prostate cancer through their roles in cellular growth, metabolism and apoptosis, however, epidemiologic results have been inconsistent. The role of obesity in prostate cancer risk is not clearly understood, but hyperinsulinemia-related increases in bioactive IGF-1 levels, associated with obesity, could be a component of the relationship between the IGF-axis and prostate cancer. We conducted a nested case-control study in the prospective Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial to examine associations between IGF-1 and IGFBP-3 and risk of prostate cancer. A total of 727 incident prostate cancer cases and 887 matched controls were selected for this analysis. There was no clear overall association between IGF-1, IGFBP-3 and IGF-1:IGFBP-3 molar ratio (IGFmr) and prostate cancer risk, however, IGFmr was associated with risk in obese men (BMI > 30, p-trend = 0.04), with a greater than 2-fold increased risk in the highest IGFmr quartile (OR 2.34, 95% CI 1.10-5.01). Risk was specifically increased for aggressive disease in obese men (OR 2.80, 95% CI 1.11-7.08). In summary, our large prospective study showed no overall association between the insulin-like growth factor axis and prostate cancer risk, however, IGFmr was related to risk for aggressive prostate cancer in obese men. JF - International Journal of Cancer AU - Weiss, Jocelyn M AU - Huang, Wen-Yi AU - Rinaldi, Sabina AU - Fears, Thomas R AU - Chatterjee, Nilanjan AU - Chia, David AU - Crawford, E David AU - Kaaks, Rudolf AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, NCI/NIH, Bethesda, MD, weissjoc@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2267 EP - 2273 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Oncogenes & Growth Factors Abstracts KW - Obesity KW - Insulin-like growth factor I KW - Ovarian cancer KW - Apoptosis KW - obesity KW - males KW - Prostate cancer KW - Lung KW - Risk factors KW - Insulin-like growth factors KW - prostate cancer KW - growth factors KW - Insulin-like growth factor-binding protein 3 KW - Metabolism KW - B 26600:Tyrosine Kinase Activity KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20649495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=IGF-1+and+IGFBP-3%3A+Risk+of+prostate+cancer+among+men+in+the+Prostate%2C+Lung%2C+Colorectal+and+Ovarian+Cancer+Screening+Trial&rft.au=Weiss%2C+Jocelyn+M%3BHuang%2C+Wen-Yi%3BRinaldi%2C+Sabina%3BFears%2C+Thomas+R%3BChatterjee%2C+Nilanjan%3BChia%2C+David%3BCrawford%2C+E+David%3BKaaks%2C+Rudolf%3BHayes%2C+Richard+B&rft.aulast=Weiss&rft.aufirst=Jocelyn&rft.date=2007-11-01&rft.volume=121&rft.issue=10&rft.spage=2267&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22921 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Insulin-like growth factor I; Obesity; Apoptosis; Prostate cancer; Risk factors; Insulin-like growth factors; Insulin-like growth factor-binding protein 3; Metabolism; Lung; obesity; males; prostate cancer; growth factors DO - http://dx.doi.org/10.1002/ijc.22921 ER - TY - JOUR T1 - Selective chromosome amplification in Vibrio cholerae AN - 20622333; 7998753 AB - Most bacteria have one chromosome but some have more than one, as is common in eukaryotes. How multiple chromosomes are maintained in bacteria remains largely obscure. Here we have examined the behaviour of the two Vibrio cholerae chromosomes as a function of growth rate. At slow growth rates, both chromosomes were maintained at copy numbers of one to two per cell. Increasing the growth rate by nutritional shift-up amplified the origin-proximal DNA of the larger chromosome (chrI) to four copies per cell, but not that of the smaller chrII. The latter was amplified when its specific initiator was supplied in excess or a specific negative regulator was deleted. The growth rate-insensitive behaviour of chrII, whose origin is similar to origins of members of a major class of plasmids, was shared by some but not all of several representative plasmids tested in V. cholerae. Also, unlike plasmid replication, chrII replication is known to be initiated at a specific stage of the cell cycle. Raising chrII copy number decreased growth rate, suggesting that this chromosome might serve as a repository for necessary but potentially deleterious genes. JF - Molecular Microbiology AU - Srivastava, Preeti AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, NCI, NIH, Bethesda, MD 20892-4260, USA., chattoraj@nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1016 EP - 1028 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 66 IS - 4 SN - 0950-382X, 0950-382X KW - ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Growth rate KW - Replication KW - Cell cycle KW - Plasmids KW - Nutrition KW - copy number KW - Vibrio cholerae KW - Chromosomes KW - Genes KW - Microorganisms KW - DNA KW - Q1 08205:Genetics and evolution KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20622333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Selective+chromosome+amplification+in+Vibrio+cholerae&rft.au=Srivastava%2C+Preeti%3BChattoraj%2C+Dhruba+K&rft.aulast=Srivastava&rft.aufirst=Preeti&rft.date=2007-11-01&rft.volume=66&rft.issue=4&rft.spage=1016&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2007.05973.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Growth rate; Chromosomes; Genes; DNA; Microorganisms; Plasmids; Nutrition; Replication; Cell cycle; copy number; Vibrio cholerae DO - http://dx.doi.org/10.1111/j.1365-2958.2007.05973.x ER - TY - JOUR T1 - Early hospital discharge versus continued hospitalization in febrile pediatric cancer patients with prolonged neutropenia: A randomized, prospective study AN - 20619979; 9331019 AB - Background Hospitalization with single or multi-agent antibiotic therapy has been the standard of care for treatment of febrile neutropenia in cancer patients. We hypothesized that an empiric antibiotic regimen that is effective and that can be administered once-daily will allow for improved hospital utilization by early transition to outpatient care. Procedure Febrile pediatric cancer patients with anticipated prolonged neutropenia were randomized between a regimen of once-daily ceftriaxone plus amikacin (C + A) and imipenem monotherapy (control). Afebrile patients on C + A satisfying Early Discharge Criteria at 72 hr continued treatment as outpatients. We compared the outcome, adverse events, duration of hospitalization, and cost between both groups. Results A prospective randomized controlled clinical trial was conducted on 129 febrile episodes in pediatric cancer patients with prolonged neutropenia. No adverse events were seen in 32 children (84% of study arm) treated on an outpatient basis. We found a statistically significant difference between the duration of hospitalization of the C + A group [median 5 days] and control [median 9 days](P < 0.001), per episode antibiotic cost (P < 0.001) and total episode cost (P < 0.001). There was no statistically significant difference in the response to treatment at 72 hr or after necessary antimicrobial modifications. Conclusions We conclude that pediatric febrile cancer patients initially considered at risk for sepsis due to prolonged neutropenia can be re-evaluated at 72 hr for outpatient therapy. The convenience, low incidence of adverse effects, and cost benefit of the once-daily regimen of C + A may be particularly useful to reduce the overall treatment costs and duration of hospitalization. Pediatr Blood Cancer 2007; 49:786-792. JF - Pediatric Blood & Cancer AU - Ahmed, Nabil AU - El-Mahallawy, Hadir A AU - Ahmed, Ibrahim A AU - Nassif, Shimaa AU - El-Beshlawy, Aamal AU - El-Haddad, Alaa AD - Pediatric Branch, National Cancer Institute, Cairo University, Cairo, Egypt, hadir38@hotmail.com Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 786 EP - 792 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 49 IS - 6 SN - 1545-5009, 1545-5009 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Amikacin KW - Pediatrics KW - Statistical analysis KW - Antibiotics KW - Ceftriaxone KW - Children KW - Clinical trials KW - Cancer KW - Antimicrobial agents KW - Imipenem KW - Blood KW - Neutropenia KW - Sepsis KW - Side effects KW - Hospitals KW - F 06915:Cancer Immunology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20619979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Blood+%26+Cancer&rft.atitle=Early+hospital+discharge+versus+continued+hospitalization+in+febrile+pediatric+cancer+patients+with+prolonged+neutropenia%3A+A+randomized%2C+prospective+study&rft.au=Ahmed%2C+Nabil%3BEl-Mahallawy%2C+Hadir+A%3BAhmed%2C+Ibrahim+A%3BNassif%2C+Shimaa%3BEl-Beshlawy%2C+Aamal%3BEl-Haddad%2C+Alaa&rft.aulast=Ahmed&rft.aufirst=Nabil&rft.date=2007-11-01&rft.volume=49&rft.issue=6&rft.spage=786&rft.isbn=&rft.btitle=&rft.title=Pediatric+Blood+%26+Cancer&rft.issn=15455009&rft_id=info:doi/10.1002%2Fpbc.21179 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Amikacin; Pediatrics; Statistical analysis; Antibiotics; Ceftriaxone; Children; Clinical trials; Cancer; Imipenem; Antimicrobial agents; Neutropenia; Blood; Sepsis; Side effects; Hospitals DO - http://dx.doi.org/10.1002/pbc.21179 ER - TY - JOUR T1 - New malignancies following childhood cancer in the United States, 1973-2002 AN - 20618478; 8079742 AB - The objectives of our study were to quantify risks for developing new malignancies among childhood cancer survivors, identify links between particular types of first and subsequent cancer, and evaluate the possible role of treatment. A cohort of 25,965 2-month survivors of childhood cancer diagnosed in the U.S. during 1973-2002 was identified and followed through SEER cancer registries. Observed-to-expected ratios (O/E) were calculated, and Poisson regression was used to compare risks among treatment groups. Childhood cancer survivors were at nearly 6-fold risk of developing a new cancer relative to the general population (O/E = 5.9, 95% CI: 5.4-6.5). Most common were subsequent primary cancers of the female breast, central nervous system, bone, thyroid gland and soft tissue, as well as cutaneous melanoma and acute non-lymphocytic leukemia (ANLL). The greatest risks of subsequent cancers occurred among patients diagnosed previously with Hodgkin lymphoma (HL), Ewing sarcoma, primitive neuroectodermal tumor, or retinoblastoma. Risk of subsequent solid cancers was higher among persons whose initial treatment for childhood cancer included radiotherapy, whereas the excess of subsequent ANLL was strongly related to chemotherapy. The O/E for subsequent ANLL increased with increasing calendar year of initial cancer diagnosis among survivors of cancers other than HL, most likely due to increasing use of leukemogenic drugs for solid cancers and non-Hodgkin lymphoma. Childhood cancer survivors are at markedly increased risk of developing a variety of new cancers relative to the general population, but the magnitude of excess risk and specific types of second cancer vary widely by type of first cancer. JF - International Journal of Cancer AU - Inskip, Peter D AU - Curtis, Rochelle E AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, MD, inskippe@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2233 EP - 2240 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 121 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - Central nervous system KW - Thyroid KW - melanoma KW - Children KW - radiotherapy KW - Cancer KW - chemotherapy KW - Bone KW - Leukemia KW - USA KW - lymphoma KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20618478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=New+malignancies+following+childhood+cancer+in+the+United+States%2C+1973-2002&rft.au=Inskip%2C+Peter+D%3BCurtis%2C+Rochelle+E&rft.aulast=Inskip&rft.aufirst=Peter&rft.date=2007-11-01&rft.volume=121&rft.issue=10&rft.spage=2233&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22827 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Bone; Leukemia; Central nervous system; Thyroid; melanoma; Children; Drugs; radiotherapy; lymphoma; chemotherapy; Cancer; USA DO - http://dx.doi.org/10.1002/ijc.22827 ER - TY - JOUR T1 - Discovery of Fur binding site clusters in Escherichia coli by information theory models AN - 20616884; 7744779 AB - Fur is a DNA binding protein that represses bacterial iron uptake systems. Eleven footprinted Escherichia coli Fur binding sites were used to create an initial information theory model of Fur binding, which was then refined by adding 13 experimentally confirmed sites. When the refined model was scanned across all available footprinted sequences, sequence walkers, which are visual depictions of predicted binding sites, frequently appeared in clusters that fit the footprints ( similar to 83% coverage). This indicated that the model can accurately predict Fur binding. Within the clusters, individual walkers were separated from their neighbors by exactly 3 or 6 bases, consistent with models in which Fur dimers bind on different faces of the DNA helix. When the E. coli genome was scanned, we found 363 unique clusters, which includes all known Fur-repressed genes that are involved in iron metabolism. In contrast, only a few of the known Fur-activated genes have predicted Fur binding sites at their promoters. These observations suggest that Fur is either a direct repressor or an indirect activator. The Pseudomonas aeruginosa and Bacillus subtilis Fur models are highly similar to the E. coli Fur model, suggesting that the Fur-DNA recognition mechanism may be conserved for even distantly related bacteria. JF - Nucleic Acids Research AU - Chen, Zehua AU - Lewis, Karen A AU - Shultzaberger, Ryan K AU - Lyakhov, Ilya G AU - Zheng, Ming AU - Doan, Bernard AU - Storz, Gisela AU - Schneider, Thomas D AD - National Cancer Institute at Frederick, Center for Cancer Research Nanobiology Program, Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201, National Institute of Child Health and Human Development, Cell Biology and Metabolism Branch and Division of Extramural Activities, Referral and Program Analysis Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 6762 EP - 6777 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 20 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Promoters KW - Bacillus subtilis KW - DNA-binding protein KW - Escherichia coli KW - Pseudomonas aeruginosa KW - Iron KW - Repressors KW - Information theory KW - Metabolism KW - Models KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20616884?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Discovery+of+Fur+binding+site+clusters+in+Escherichia+coli+by+information+theory+models&rft.au=Chen%2C+Zehua%3BLewis%2C+Karen+A%3BShultzaberger%2C+Ryan+K%3BLyakhov%2C+Ilya+G%3BZheng%2C+Ming%3BDoan%2C+Bernard%3BStorz%2C+Gisela%3BSchneider%2C+Thomas+D&rft.aulast=Chen&rft.aufirst=Zehua&rft.date=2007-11-01&rft.volume=35&rft.issue=20&rft.spage=6762&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Promoters; DNA-binding protein; Repressors; Iron; Metabolism; Information theory; Models; Bacillus subtilis; Escherichia coli; Pseudomonas aeruginosa ER - TY - JOUR T1 - Genetic basis for retention of a critical virulence plasmid of Borrelia burgdorferi AN - 20591837; 7998750 AB - The genome of Borrelia burgdorferi is composed of one linear chromosome and approximately 20 linear and circular plasmids. Although some plasmids are required by B. burgdorferi in vivo, most plasmids are dispensable for growth in vitro. However, circular plasmid (cp) 26 is present in all natural isolates and has never been lost during in vitro growth. This plasmid carries ospC, which is critical for mammalian infection. We previously showed that cp26 encodes essential functions, including the telomere resolvase, ResT, and hence cannot be displaced. Here we identify two additional essential genes on cp26, bbb26 and bbb27, through a systematic attempt to inactivate each open reading frame (ORF). Furthermore, an incompatible plasmid carrying resT, bbb26 and bbb27 could displace cp26. Computational and experimental analyses suggested that both BBB26 and BBB27 are membrane-associated, periplasmic proteins. These data indicate that bbb26 and bbb27 encode essential but possibly redundant functions and that one or the other of these cp26 genes, in addition to resT, is required for bacterial viability. We conclude that the genetic linkage of critical physiological and virulence functions on cp26 is pertinent to its stable maintenance throughout the evolution of B. burgdorferi. JF - Molecular Microbiology AU - Jewett, Mollie W AU - Byram, Rebecca AU - Bestor, Aaron AU - Tilly, Kit AU - Lawrence, Kevin AU - Burtnick, Mary N AU - Gherardini, Frank AU - Rosa, Patricia A AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA., prosa@nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 975 EP - 990 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 66 IS - 4 SN - 0950-382X, 0950-382X KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Genomes KW - Telomeres KW - Borrelia burgdorferi KW - Plasmids KW - Infection KW - Computer applications KW - Open reading frames KW - Evolution KW - Resolvase KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20591837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Genetic+basis+for+retention+of+a+critical+virulence+plasmid+of+Borrelia+burgdorferi&rft.au=Jewett%2C+Mollie+W%3BByram%2C+Rebecca%3BBestor%2C+Aaron%3BTilly%2C+Kit%3BLawrence%2C+Kevin%3BBurtnick%2C+Mary+N%3BGherardini%2C+Frank%3BRosa%2C+Patricia+A&rft.aulast=Jewett&rft.aufirst=Mollie&rft.date=2007-11-01&rft.volume=66&rft.issue=4&rft.spage=975&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2007.05969.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genomes; Virulence; Telomeres; Computer applications; Infection; Plasmids; Evolution; Open reading frames; Resolvase; Borrelia burgdorferi DO - http://dx.doi.org/10.1111/j.1365-2958.2007.05969.x ER - TY - JOUR T1 - Identification of enzymes and regulatory proteins in Escherichia coli that are oxidized under nitrogen, carbon, or phosphate starvation AN - 20551983; 7745751 AB - Using proteomic technologies, we identified 62 proteins that are oxidized to carbonyl derivatives during growth of Escherichia coli under nitrogen starvation (NS), carbon starvation (CS), and phosphate starvation (PS) conditions. The carbonylated proteins were converted to 2,4-dinitrophenylhydrazone derivatives and these were identified using Western blotting and mass spectrometry by searching E. coli proteins in the Swiss-Prot and/or NCBI databases. Fourteen of the oxidized proteins were formed under both NS and CS conditions, and only three proteins were specifically oxidized under PS conditions. Interestingly, the carbonyl content of proteins in crude extracts of cells harvested after 48 h of stationary growth under NS and CS was significantly lower than that observed at mid-log and end-log phases of growth. In contrast, the carbonyl content of proteins in extracts of cells grown under PS conditions was fairly constant during comparable periods of growth. JF - Proceedings of the National Academy of Sciences, USA AU - Noda, Yasuko AU - Berlett, Barbara S AU - Stadtman, Earl R AU - Aponte, Angel AU - Morgan, Meghan AU - Shen, Rong-Fong AD - Laboratory of Biochemistry, Biochemistry and Biophysics Center, and Proteomics Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-8012 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 18456 EP - 18460 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 47 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Starvation KW - Western blotting KW - Enzymes KW - Mass spectroscopy KW - Computer programs KW - Databases KW - Carbon KW - Phosphate KW - regulatory proteins KW - Escherichia coli KW - proteomics KW - carbonyls KW - Nitrogen KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20551983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Identification+of+enzymes+and+regulatory+proteins+in+Escherichia+coli+that+are+oxidized+under+nitrogen%2C+carbon%2C+or+phosphate+starvation&rft.au=Noda%2C+Yasuko%3BBerlett%2C+Barbara+S%3BStadtman%2C+Earl+R%3BAponte%2C+Angel%3BMorgan%2C+Meghan%3BShen%2C+Rong-Fong&rft.aulast=Noda&rft.aufirst=Yasuko&rft.date=2007-11-01&rft.volume=104&rft.issue=47&rft.spage=18456&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Starvation; Western blotting; Databases; Computer programs; Carbon; regulatory proteins; Phosphate; Enzymes; proteomics; carbonyls; Mass spectroscopy; Nitrogen; Escherichia coli ER - TY - JOUR T1 - Comparative Genomic Analyses of Seventeen Streptococcus pneumoniae Strains: Insights into the Pneumococcal Supragenome AN - 20548743; 7741895 AB - The distributed-genome hypothesis (DGH) states that pathogenic bacteria possess a supragenome that is much larger than the genome of any single bacterium and that these pathogens utilize genetic recombination and a large, noncore set of genes as a means of diversity generation. We sequenced the genomes of eight nasopharyngeal strains of Streptococcus pneumoniae isolated from pediatric patients with upper respiratory symptoms and performed quantitative genomic analyses among these and nine publicly available pneumococcal strains. Coding sequences from all strains were grouped into 3,170 orthologous gene clusters, of which 1,454 (46%) were conserved among all 17 strains. The majority of the gene clusters, 1,716 (54%), were not found in all strains. Genic differences per strain pair ranged from 35 to 629 orthologous clusters, with each strain's genome containing between 21 and 32% noncore genes. The distribution of the orthologous clusters per genome for the 17 strains was entered into the finite-supragenome model, which predicted that (i) the S. pneumoniae supragenome contains more than 5,000 orthologous clusters and (ii) 99% of the orthologous clusters ( similar to 3,000) that are represented in the S. pneumoniae population at frequencies of greater than or equal to 0.1 can be identified if 33 representative genomes are sequenced. These extensive genic diversity data support the DGH and provide a basis for understanding the great differences in clinical phenotype associated with various pneumococcal strains. When these findings are taken together with previous studies that demonstrated the presence of a supragenome for Streptococcus agalactiae and Haemophilus influenzae, it appears that the possession of a distributed genome is a common host interaction strategy. JF - Journal of Bacteriology AU - Hiller, NLuisa AU - Janto, Benjamin AU - Hogg, Justin S AU - Boissy, Robert AU - Yu, Susan AU - Powell, Evan AU - Keefe, Randy AU - Ehrlich, Nathan E AU - Shen, Kai AU - Hayes, Jay AU - Barbadora, Karen AU - Klimke, William AU - Dernovoy, Dmitry AU - Tatusova, Tatiana AU - Parkhill, Julian AU - Bentley, Stephen D AU - Post, JChristopher AU - Ehrlich, Garth D AU - Hu, Fen Z AD - Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences. Department of Microbiology and Immunology, Drexel University College of Medicine, Allegheny Campus, Pittsburgh, Pennsylvania 15212. Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, 15213. National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894. The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, United Kingdom Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 8186 EP - 8195 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 22 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Recombination KW - Streptococcus pneumoniae KW - Haemophilus influenzae KW - Pediatrics KW - Streptococcus agalactiae KW - Genomic analysis KW - Pathogens KW - Models KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20548743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Comparative+Genomic+Analyses+of+Seventeen+Streptococcus+pneumoniae+Strains%3A+Insights+into+the+Pneumococcal+Supragenome&rft.au=Hiller%2C+NLuisa%3BJanto%2C+Benjamin%3BHogg%2C+Justin+S%3BBoissy%2C+Robert%3BYu%2C+Susan%3BPowell%2C+Evan%3BKeefe%2C+Randy%3BEhrlich%2C+Nathan+E%3BShen%2C+Kai%3BHayes%2C+Jay%3BBarbadora%2C+Karen%3BKlimke%2C+William%3BDernovoy%2C+Dmitry%3BTatusova%2C+Tatiana%3BParkhill%2C+Julian%3BBentley%2C+Stephen+D%3BPost%2C+JChristopher%3BEhrlich%2C+Garth+D%3BHu%2C+Fen+Z&rft.aulast=Hiller&rft.aufirst=NLuisa&rft.date=2007-11-01&rft.volume=189&rft.issue=22&rft.spage=8186&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Recombination; Pediatrics; Genomic analysis; Pathogens; Models; Streptococcus pneumoniae; Haemophilus influenzae; Streptococcus agalactiae ER - TY - JOUR T1 - Multiple Introductions of the Old World Begomovirus Tomato yellow leaf curl virus into the New World AN - 20508630; 7928190 AB - A phylogenetic analysis of three genomic regions revealed that Tomato yellow leaf curl virus (TYLCV) from western North America is distinct from TYLCV isolated in eastern North America and the Caribbean. This analysis supports a second introduction of this Old World begomovirus into the New World, most likely from Asia. JF - Applied and Environmental Microbiology AU - Duffy, Siobain AU - Holmes, Edward C AD - Center for Infectious Disease Dynamics, Department of Biology, Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802. Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 7114 EP - 7117 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 21 SN - 0099-2240, 0099-2240 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Begomovirus KW - Phylogeny KW - yellow leaf KW - Tomato yellow leaf curl virus KW - genomics KW - A 01360:Plant Diseases KW - V 22420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20508630?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Multiple+Introductions+of+the+Old+World+Begomovirus+Tomato+yellow+leaf+curl+virus+into+the+New+World&rft.au=Duffy%2C+Siobain%3BHolmes%2C+Edward+C&rft.aulast=Duffy&rft.aufirst=Siobain&rft.date=2007-11-01&rft.volume=73&rft.issue=21&rft.spage=7114&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phylogeny; yellow leaf; genomics; Begomovirus; Tomato yellow leaf curl virus ER - TY - JOUR T1 - Improved BLAST searches using longer words for protein seeding AN - 20498081; 7929366 AB - MOTIVATION: The blastp and tblastn modules of BLAST are widely used methods for searching protein queries against protein and nucleotide databases, respectively. One heuristic used in BLAST is to consider only database sequences that contain a high-scoring match of length at most 5 to the query. We implemented the capability to use words of length 6 or 7. We demonstrate an improved trade-off between running time and retrieval accuracy, controlled by the score threshold used for short word matches. For example, the running time can be reduced by 20-30% while achieving ROC (receiver operator characteristic) scores similar to those obtained with current default parameters. AVAILABILITY: The option to use long words is in the NCBI C and C++ toolkit code for BLAST, starting with version 2.2.16 of blastall. A Linux executable used to produce the results herein is available at: ftp://ftp.ncbi.nlm.nih.gov/pub/agarwala/protein_longwords. JF - Bioinformatics AU - Shiryev, Sergey A AU - Papadopoulos, Jason S AU - Schaeffer, Alejandro A AU - Agarwala, Richa AD - Department of Health and Human Services, National Center for Biotechnology Information, National Institutes of Health, richa@helix.nih.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 2949 EP - 2951 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples[at]oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 21 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Seeding KW - Problem solving KW - Bioinformatics KW - Nucleotides KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20498081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Improved+BLAST+searches+using+longer+words+for+protein+seeding&rft.au=Shiryev%2C+Sergey+A%3BPapadopoulos%2C+Jason+S%3BSchaeffer%2C+Alejandro+A%3BAgarwala%2C+Richa&rft.aulast=Shiryev&rft.aufirst=Sergey&rft.date=2007-11-01&rft.volume=23&rft.issue=21&rft.spage=2949&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Databases; Problem solving; Seeding; Bioinformatics; Nucleotides ER - TY - JOUR T1 - In vivo Diagnosis of Epidermal Growth Factor Receptor Expression using Molecular Imaging with a Cocktail of Optically Labeled Monoclonal Antibodies AN - 20460289; 7930774 AB - PURPOSE: Epidermal growth factor receptors (EGFR) play an important role in tumorigenesis and, therefore, have become targets for new molecular therapies. Here, we use a "cocktail" of optically labeled monoclonal antibodies directed against EGFR-1 (HER1) and EGFR-2 (HER2) to distinguish tumors by their cell surface expression profiles. Experimental Design: In vivo imaging experiments were done in tumor-bearing mice following s.c. injection of A431 (overexpressing HER1), NIH3T3/HER2+ (overexpressing HER2), and Balb3T3/DsRed (non-expression control) cell lines. After tumor establishment, a cocktail of optically labeled antibodies: Cy5.5-labeled cetuximab (anti-HER1) and Cy7-labeled trastuzumab (anti-HER2) was i.v. injected. In vivo and ex vivo fluorescence imaging was done. For comparison with radionuclide imaging, experiments were undertaken using super(111)Indium-labeled antibodies. Additionally, a "blinded" diagnostic study was done for mice bearing one tumor type. RESULTS: In vivo spectral fluorescent molecular imaging of 14 mice with three tumor types clearly differentiated tumors using the cocktail of optically labeled antibodies both in vivo and ex vivo. Twenty-four hours after injection, A431 and NIH3T3/HER2+ tumors were detected distinctly by their peak on Cy5.5 and Cy7 spectral images, respectively; radionuclide imaging was unable to clearly distinguish tumors at this time point. In blinded single tumor experiments, investigators were able to correctly diagnose a total of 40 tumors. CONCLUSION: An in vivo imaging technique using an antibody cocktail simultaneously differentiated two tumors expressing distinct EGFRs and enabled an accurate characterization of each subtype. JF - Clinical Cancer Research AU - Barrett, Tristan AU - Koyama, Yoshinori AU - Hama, Yukihiro AU - Ravizzini, Gregory AU - Shin, In Soo AU - Jang, Beom-Su AU - Paik, Chang H AU - Urano, Yasuteru AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Authors' Affiliations: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, and Nuclear Medicine Department, Warren Magnuson Clinical Center, NIH, Bethesda, Maryland Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 6639 EP - 6648 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 22 SN - 1078-0432, 1078-0432 KW - Oncogenes & Growth Factors Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - ErbB-2 protein KW - Fluorescence KW - Monoclonal antibodies KW - Tumorigenesis KW - Radioisotopes KW - Epidermal growth factor receptors KW - trastuzumab KW - imaging KW - W 30910:Imaging KW - B 26600:Tyrosine Kinase Activity KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20460289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=In+vivo+Diagnosis+of+Epidermal+Growth+Factor+Receptor+Expression+using+Molecular+Imaging+with+a+Cocktail+of+Optically+Labeled+Monoclonal+Antibodies&rft.au=Barrett%2C+Tristan%3BKoyama%2C+Yoshinori%3BHama%2C+Yukihiro%3BRavizzini%2C+Gregory%3BShin%2C+In+Soo%3BJang%2C+Beom-Su%3BPaik%2C+Chang+H%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Barrett&rft.aufirst=Tristan&rft.date=2007-11-01&rft.volume=13&rft.issue=22&rft.spage=6639&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell surface; Fluorescence; ErbB-2 protein; Monoclonal antibodies; Tumorigenesis; Radioisotopes; Epidermal growth factor receptors; trastuzumab; imaging ER - TY - JOUR T1 - Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance AN - 20455959; 7930272 AB - Camptothecin (CPT) derivatives are effective anticancer drugs, especially against solid tumors. As CPTs are chemically unstable and have clinical limitations, we have synthesized indenoisoquinolines as novel topoisomerase I (Top1) inhibitors. We presently report two indenoisoquinoline derivatives, NSC 725776 and NSC 724998, which have been selected for therapeutic development. Both are potent Top1 inhibitors and induce Top1 cleavage at unique genomic positions compared with CPT. Consistent with Top1 poisoning, protein-linked DNA breaks were detected in cells treated with NSC 725776 and NSC 724998 at nanomolar concentrations. Those drug-induced protein-linked DNA breaks persisted longer after drug removal than those produced by CPT. Studies in human cells in culture show that NSC 725776 and NSC 724998 exert antiproliferative activity at submicromolar concentrations. Furthermore, NSC 725776 and NSC 724998 show cross-resistance in cells deficient or silenced for Top1, which is consistent with their selective Top1 targeting. Similar to other known Top1 inhibitors, NSC 725776-treated and NSC 724998-treated cells show an arrest of cell cycle progression in both S and G sub(2)-M and a dependence on functional p53 for their cytotoxicity. Dose-dependent gamma -H2AX foci formation was readily observed in cells treated with NSC 725776 and NSC 724998. These gamma -H2AX foci were detectable at pharmacologically relevant doses for up to 24 h and thus could be used as biomarkers for clinical trials (phase 0). [Cancer Res 2007; 67(21):10397-405] JF - Cancer Research AU - Antony, Smitha AU - Agama, Keli K AU - Miao, Ze-Hong AU - Takagi, Kazutaka AU - Wright, Mollie H AU - Robles, Ana I AU - Varticovski, Lyuba AU - Nagarajan, Muthukaman AU - Morrell, Andrew AU - Cushman, Mark AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology and Laboratory of Human Carcinogenesis, National Cancer Institute, NIH, Bethesda, Maryland and Department of Medicinal Chemistry and Molecular Pharmacology, and the Purdue Cancer Center, Purdue University, West Lafayette, Indiana Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 10397 EP - 10405 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 21 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Solid tumors KW - Cell cycle KW - Poisoning KW - DNA topoisomerase KW - Cell culture KW - Clinical trials KW - biomarkers KW - Cancer KW - Camptothecin KW - p53 protein KW - DNA damage KW - Cytotoxicity KW - Multidrug resistance KW - genomics KW - Cross-resistance KW - Drugs KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20455959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Novel+Indenoisoquinolines+NSC+725776+and+NSC+724998+Produce+Persistent+Topoisomerase+I+Cleavage+Complexes+and+Overcome+Multidrug+Resistance&rft.au=Antony%2C+Smitha%3BAgama%2C+Keli+K%3BMiao%2C+Ze-Hong%3BTakagi%2C+Kazutaka%3BWright%2C+Mollie+H%3BRobles%2C+Ana+I%3BVarticovski%2C+Lyuba%3BNagarajan%2C+Muthukaman%3BMorrell%2C+Andrew%3BCushman%2C+Mark%3BPommier%2C+Yves&rft.aulast=Antony&rft.aufirst=Smitha&rft.date=2007-11-01&rft.volume=67&rft.issue=21&rft.spage=10397&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Solid tumors; Cell cycle; DNA topoisomerase; Poisoning; Cell culture; biomarkers; Clinical trials; Camptothecin; Cancer; p53 protein; DNA damage; Cytotoxicity; Multidrug resistance; genomics; Drugs; Cross-resistance ER - TY - JOUR T1 - A Self-Quenched Galactosamine-Serum Albumin-RhodamineX Conjugate: A "Smart" Fluorescent Molecular Imaging Probe Synthesized with Clinically Applicable Material for Detecting Peritoneal Ovarian Cancer Metastases AN - 20452813; 7930734 AB - PURPOSE: Fluorophore activation after cellular internalization of a targeted fluorescently labeled conjugate is an effective molecular imaging strategy to increase target-to-background ratios. The D-galactose receptor on ovarian cancer cells has been used to target self-quenched avidin-rhodamineX conjugates in which the avidin component binds to D-galactose receptor and the rhodamines are optically activated by dequenching only after cellular internalization. As a nonimmunogenic alternative of avidin, galactosamine-conjugated serum albumin (GmSA) targets the D-galactose receptor with higher binding affinity and has more conjugation sites available for rhodamineX than avidin. Experimental Design: GmSA was conjugated with 20 rhodamineX molecules (GmSA-20ROX) to create a self-quenching complex, which was compared with a conjugate consisting of GmSA and a single rhodamineX (GmSA-1ROX) in ex vivo chemical activation characteristics, intracellular activation, and in vivo molecular imaging for detecting peritoneal micrometastases of SHIN3 ovarian cancer. RESULTS: GmSA-20ROX was five times brighter than GmSA-1ROX when incubated with SHIN3 ovarian cancer cells for 3 h. Submillimeter SHIN3 ovarian cancer implants in the peritoneal cavity were clearly visualized in vivo with spectral fluorescence imaging due to the high tumor-to-background ratio. The sensitivity and specificity of GmSA-20ROX for implant detection were determined by colocalization of the rhodamineX emission with red fluorescent protein expressed constitutively in the SHIN3 tumor implants. Among 336 lesions, sensitivity and specificity were 99%/99%, respectively, for GmSA-20ROX, whereas the results for GmSA-1ROX were only 24%/100% (n = 388), respectively, for lesions similar to 0.8 mm or greater in diameter. CONCLUSION: Self-quenched GmSA-20ROX is more efficient than previous D-galactose-targeted fluorescent conjugates. JF - Clinical Cancer Research AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Gunn, Andrew J AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Authors' Affiliations: Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 6335 EP - 6343 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 21 SN - 1078-0432, 1078-0432 KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Fluorescence KW - Peritoneum KW - D-Galactose KW - fluorophores KW - Tumors KW - imaging KW - Metastases KW - Avidin KW - red fluorescent protein KW - Albumin KW - Fluorescent indicators KW - rhodamine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20452813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Self-Quenched+Galactosamine-Serum+Albumin-RhodamineX+Conjugate%3A+A+%22Smart%22+Fluorescent+Molecular+Imaging+Probe+Synthesized+with+Clinically+Applicable+Material+for+Detecting+Peritoneal+Ovarian+Cancer+Metastases&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BGunn%2C+Andrew+J%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-11-01&rft.volume=13&rft.issue=21&rft.spage=6335&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Fluorescence; Peritoneum; D-Galactose; Tumors; fluorophores; imaging; Metastases; Avidin; red fluorescent protein; Albumin; Fluorescent indicators; rhodamine ER - TY - JOUR T1 - Quality Control of Serum Albumin Depletion for Proteomic Analysis AN - 20451167; 7930819 AB - BACKGROUND: Prefractionation techniques such as serum albumin depletion are useful precursors to proteomic analysis, but they may introduce preanalytical bias if the depletion is not reproducible. We examined the reproducibility of albumin immunodepletion and describe a method of QC for this process. METHODS: Depletion of albumin from pooled serum, performed using IgY immunoaffinity spin columns, was assessed for 21 runs on each of 4 columns. We measured albumin concentrations, after albumin depletion, by use of an immunoturbidimetric assay on the Beckman LX 20 analyzer and assessed mass spectra of albumin-depleted samples by use of SELDI-TOF mass spectrometry. RESULTS: There was substantial run-to-run variation in efficiency of albumin depletion, with systematic decline in efficiency after multiple uses of the columns. Mean depletion efficiency was >95% for 15 of the 1st 17 runs and <90% for runs 18 to 21. We evaluated the 10 highest-intensity peaks present in all spectra from runs 1, 8, 17, and 21 and assessed the effect of albumin depletion on SELDI-TOF mass spectrometry reproducibility. Comparing the %CV of relative intensities for low and high m/z measurements revealed a significant difference of run 21 compared with runs 1, 8, and 17 (P <0.0001). Six-fold more peaks were found in albumin-depleted than unfractionated serum at both high and low m/z. CONCLUSIONS: Sporadic and systematic variation in efficiency of albumin depletion by spin columns may contribute significant preanalytical bias to proteomic approaches of biomarker discovery. This variation requires ongoing QC of the albumin depletion process by quantification of albumin concentration to assess depletion efficiency. JF - Clinical Chemistry AU - Seam, Nitin AU - Gonzales, Denise A AU - Kern, Steven J AU - Hortin, Glen L AU - Hoehn, Gerard T AU - Suffredini, Anthony F AD - Critical Care Medicine Department and Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1915 EP - 1920 PB - American Association for Clinical Chemistry, Inc. VL - 53 IS - 11 SN - 0009-9147, 0009-9147 KW - Biotechnology and Bioengineering Abstracts KW - Quality control KW - Albumin KW - proteomics KW - biomarkers KW - Mass spectroscopy KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20451167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Chemistry&rft.atitle=Quality+Control+of+Serum+Albumin+Depletion+for+Proteomic+Analysis&rft.au=Seam%2C+Nitin%3BGonzales%2C+Denise+A%3BKern%2C+Steven+J%3BHortin%2C+Glen+L%3BHoehn%2C+Gerard+T%3BSuffredini%2C+Anthony+F&rft.aulast=Seam&rft.aufirst=Nitin&rft.date=2007-11-01&rft.volume=53&rft.issue=11&rft.spage=1915&rft.isbn=&rft.btitle=&rft.title=Clinical+Chemistry&rft.issn=00099147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Quality control; Albumin; proteomics; biomarkers; Mass spectroscopy ER - TY - JOUR T1 - Designer Schools: The Role of School Space and Architecture in Obesity Prevention AN - 20446899; 7936882 AB - Spatial features of obesogenic environments studied on a broad community level have been associated with childhood overweight and obesity, but little research has focused on the effects of the design of micro spaces, such as schools, on individual health behaviors. This article aims to generate thinking and research on the link between school space and architecture and obesity prevention by reviewing and synthesizing available literature in architecture, environmental psychology, and obesity research, in an effort to propose promising ideas for school space design and redesign. The school environment is defined through 5 dimensions: physical, legal, policy, social, and cultural domains. Theories underlying environmental interventions and documented associations between the environment and health behaviors and outcomes are reviewed to illustrate how existing environmental research could translate to obesity prevention. Design strategies aimed at promoting physical activity and healthful eating are proposed, with particular emphasis on the design of cafeterias, activity spaces, connectivity with the larger community, and student health centers. JF - Obesity Research AU - Gorman, Nicholas AU - Lackney, Jeffery A AU - Rollings, Kimberly AU - Huang, Terry T-K AD - Institute of Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California. Department of Engineering Professional Development, College of Engineering, and Department of Interior Design, School of Human Ecology, University of Wisconsin, Madison, Wisconsin. School of Architecture and Urban Planning, University of Wisconsin, Milwaukee, Wisconsin. Endocrinology, Nutrition, and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2521 EP - 2530 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 15 IS - 11 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Research (statistical design) KW - Eating disorders KW - Preventive health KW - Psychology KW - Strategy KW - Environmental health KW - Health (behavior) KW - Exercise KW - Students KW - Schools KW - Objectives KW - Community health KW - Policy KW - School health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20446899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Designer+Schools%3A+The+Role+of+School+Space+and+Architecture+in+Obesity+Prevention&rft.au=Gorman%2C+Nicholas%3BLackney%2C+Jeffery+A%3BRollings%2C+Kimberly%3BHuang%2C+Terry+T-K&rft.aulast=Gorman&rft.aufirst=Nicholas&rft.date=2007-11-01&rft.volume=15&rft.issue=11&rft.spage=2521&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Obesity; Research (statistical design); Psychology; Preventive health; Eating disorders; Strategy; Health (behavior); Environmental health; Exercise; Students; Schools; Policy; Community health; Objectives; School health ER - TY - JOUR T1 - Radiation dosimetry for highly contaminated belarusian, Russian and Ukrainian populations, and for less contaminated populations in Europe AN - 20433117; 7662143 AB - The explosions at the Chernobyl Nuclear Power Plant (CNPP) in Ukraine early in the morning of 26 April 1986 led to a considerable release of radioactive materials during 10 d. The cloud from the reactor spread many different radionuclides, particularly those of iodine ( super(131)I) and cesium ( super(134)Cs and super(137)Cs), over the majority of European countries, but the greatest contamination occurred over vast areas of Belarus, the Russian Federation and Ukraine. As the major health effect of Chernobyl is an elevated thyroid cancer incidence in children and adolescents, much attention has been paid to the thyroid doses resulting from intakes of super(131)I, which were delivered within 2 mo following the accident. The thyroid doses received by the inhabitants of the contaminated areas of Belarus, Russia, and Ukraine varied in a wide range, mainly according to age, level of ground contamination, milk consumption rate, and origin of the milk that was consumed. Reported individual thyroid doses varied up to similar to 40,000 mGy, with average doses of a few to 1,000 mGy, depending on the area where people were exposed. In addition, the presence in the environment of long-lived super(134)Cs and super(137)Cs has led to a relatively homogeneous exposure of all organs and tissues of the body via external and internal irradiation, albeit at low rates. Excluding the thyroid doses, the whole-body (or effective) dose estimates for the general population accumulated during 20 y after the accident (1986-2005) range from a few millisieverts (mSv) to some hundred mSv with an average dose of similar to 10 mSv in the contaminated areas of Belarus, Russia, and Ukraine. In other European countries, both the thyroid and the effective doses are, on average, much smaller. JF - Health Physics AU - Bouville, A AU - Likhtarev, IA AU - Kovgan, L N AU - Minenko, V F AU - Shinkarev, S M AU - Drozdovitch, V V AD - NCI, 6120 Executive Boulevard, EPS-7094, Bethesda, MD 20892, USA, bouvilla@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 487 EP - 501 VL - 93 IS - 5 SN - 0017-9078, 0017-9078 KW - Pollution Abstracts KW - Belarus KW - Ukraine, Chernobyl KW - Age KW - Ukraine KW - Thyroid KW - Europe KW - Radiation dosimetry KW - Children KW - Organs KW - Explosions KW - Cancer KW - Clouds KW - Nuclear power plants KW - Accidents KW - Nuclear reactors KW - Radioactive materials KW - Iodine KW - Russia KW - Adolescents KW - P 8000:RADIATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20433117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Physics&rft.atitle=Radiation+dosimetry+for+highly+contaminated+belarusian%2C+Russian+and+Ukrainian+populations%2C+and+for+less+contaminated+populations+in+Europe&rft.au=Bouville%2C+A%3BLikhtarev%2C+IA%3BKovgan%2C+L+N%3BMinenko%2C+V+F%3BShinkarev%2C+S+M%3BDrozdovitch%2C+V+V&rft.aulast=Bouville&rft.aufirst=A&rft.date=2007-11-01&rft.volume=93&rft.issue=5&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Health+Physics&rft.issn=00179078&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Thyroid; Radiation dosimetry; Children; Organs; Cancer; Explosions; Clouds; Nuclear power plants; Accidents; Nuclear reactors; Radioactive materials; Iodine; Adolescents; Belarus; Ukraine, Chernobyl; Ukraine; Europe; Russia ER - TY - JOUR T1 - Gender Differences in Serotype 2 Adeno-Associated Virus Biodistribution After Administration to Rodent Salivary Glands AN - 20415604; 7768214 AB - Salivary glands (SGs) have proven useful targets for clinical applications of gene therapeutics. In this toxicology and biodistribution study, which conforms to U.S. Food and Drug Administration Good Laboratory Practice regulations, four doses (10 super(7)-10 super(10) particles) of a serotype 2 adeno-associated viral (AAV2) vector encoding human erythropoietin were directly administered to the right submandibular gland of male and female BALB/c mice (n = 21 per gender dose group). Control-treated (saline administered; n = 66) and vector-treated (n = 168) animals did not differ in clinical appearance, morbidity and mortality rates, food and water consumption, weight gain ratios, and final weight. Clinical hematology values also were unaffected by AAV2 administration except for parameters influenced by the expression of the recombinant protein (e.g., hematocrit). Mice were killed on days 3, 30, 55, and 92. No major vector-related toxicity was uncovered after complete pathology and histopathology review. However, a significant gender-related difference in vector biodistribution was revealed by quantitative polymerase chain reaction. In male mice vector (group receiving 10 super(10) particles/animal) effectively transduced, and was primarily confined within, the SGs (i.e., similar to 800 times more copies in SGs than in liver; day 3) and long lived. In contrast, in female mice, SG transduction was less efficient (260-fold less than in males; day 3) and short lived, and vector was disseminated widely via both the bloodstream (SG:liver copy ratio, similar to 1) and saliva (30-fold greater than in males). The observed vector biodistribution is likely due to differences in AAV2 receptor targets and structural differences affecting SG integrity. Sexual dimorphism is a factor of major significance that could potentially affect gene therapy clinical applications in SGs. JF - Human Gene Therapy AU - Voutetakis, A AU - Zheng, C AU - Wang, J AU - Goldsmith, C M AU - Afione, S AU - Chiorini, JA AU - Wenk, M L AU - Vallant, M AU - Irwin, R D AU - Baum, B J AD - Building 10, Room 1N113, Bethesda, MD 20892-1190, USA, bbaum@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1109 EP - 1118 VL - 18 IS - 11 SN - 1043-0342, 1043-0342 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Mortality KW - Sexual dimorphism KW - Serotypes KW - Gene therapy KW - Toxicity KW - Salivary gland KW - Sex differences KW - Adeno-associated virus KW - Morbidity KW - Food consumption KW - Erythropoietin KW - Reviews KW - Liver KW - Hematocrit KW - Polymerase chain reaction KW - Submandibular gland KW - Saliva KW - Body weight gain KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20415604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Gene+Therapy&rft.atitle=Gender+Differences+in+Serotype+2+Adeno-Associated+Virus+Biodistribution+After+Administration+to+Rodent+Salivary+Glands&rft.au=Voutetakis%2C+A%3BZheng%2C+C%3BWang%2C+J%3BGoldsmith%2C+C+M%3BAfione%2C+S%3BChiorini%2C+JA%3BWenk%2C+M+L%3BVallant%2C+M%3BIrwin%2C+R+D%3BBaum%2C+B+J&rft.aulast=Voutetakis&rft.aufirst=A&rft.date=2007-11-01&rft.volume=18&rft.issue=11&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/10.1089%2Fhum.2007.072 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sexual dimorphism; Mortality; Serotypes; Gene therapy; Toxicity; Sex differences; Salivary gland; Morbidity; Food consumption; Erythropoietin; Reviews; Liver; Polymerase chain reaction; Hematocrit; Submandibular gland; Saliva; Body weight gain; Adeno-associated virus DO - http://dx.doi.org/10.1089/hum.2007.072 ER - TY - JOUR T1 - Spatial and temporal patterns of alkaloid variation in the poison frog Oophaga pumilio in Costa Rica and Panama over 30 years AN - 20410406; 7637489 AB - A total of 232 alkaloids, representing 21 structural classes were detected in skin extracts from the dendrobatid poison frog Oophaga pumilio, collected from 53 different populations from over 30 years of research. The highly toxic pumiliotoxins and allopumiliotoxins, along with 5,8-disubstitiuted and 5,6,8-trisubstituted indolizidines, all of which are proposed to be of dietary mite origin, were common constituents in most extracts. One decahydroquinoline (DHQ), previously shown be of ant origin, occurred in many extracts often as a major alkaloid, while other DHQs occurred rather infrequently. Histrionicotoxins, thought to be of ant origin, did not appear to possess a specific pattern of occurrence among the populations, but when present, were usually found as major components. Certain 3,5-disubstituted pyrrolizidines and indolizidines, known to be of ant origin, did occur in extracts, but infrequently. Alkaloid composition differed with regard to geographic location of frog populations, and for populations that were sampled two or more times during the 30-year period significant changes in alkaloid profiles sometimes occurred. The results of this study indicate that chemical defense in a dendrobatid poison frog is dependent on geographic location and habitat type, which presumably controls the abundance and nature of alkaloid-containing arthropods. JF - Toxicon AU - Saporito, R A AU - Donnelly, MA AU - Jain, P AU - Martin Garraffo, H AU - Spande, T F AU - Daly, J W AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA, jdaly@nih.gov Y1 - 2007/11// PY - 2007 DA - November 2007 SP - 757 EP - 778 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl] VL - 50 IS - 6 SN - 0041-0101, 0041-0101 KW - Ants KW - ASFA 1: Biological Sciences & Living Resources; Toxicology Abstracts KW - Panama KW - Geographical distribution KW - Skin KW - Amphibiotic species KW - Biochemistry KW - Biological poisons KW - Costa Rica KW - Abundance KW - Anura KW - Formicidae KW - Animal physiology KW - Freshwater KW - Habitat KW - Alkaloids KW - Arthropoda KW - Oophaga pumilio KW - X 24370:Natural Toxins KW - Q1 08326:Physiology, biochemistry, biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20410406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Spatial+and+temporal+patterns+of+alkaloid+variation+in+the+poison+frog+Oophaga+pumilio+in+Costa+Rica+and+Panama+over+30+years&rft.au=Saporito%2C+R+A%3BDonnelly%2C+MA%3BJain%2C+P%3BMartin+Garraffo%2C+H%3BSpande%2C+T+F%3BDaly%2C+J+W&rft.aulast=Saporito&rft.aufirst=R&rft.date=2007-11-01&rft.volume=50&rft.issue=6&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2007.06.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Geographical distribution; Alkaloids; Biochemistry; Amphibiotic species; Biological poisons; Animal physiology; Skin; Abundance; Habitat; Arthropoda; Oophaga pumilio; Formicidae; Anura; Panama; Costa Rica; Freshwater DO - http://dx.doi.org/10.1016/j.toxicon.2007.06.022 ER - TY - JOUR T1 - Polycyclic aromatic hydrocarbon-DNA adducts in cervix of women infected with carcinogenic human papillomavirus types: An immunohistochemistry study AN - 20395501; 7785981 AB - Among women infected with carcinogenic human papillomavirus (HPV), there is a two- to five-fold increased risk of cervical precancer and cancer in women who smoke compared to those who do not smoke. Because tobacco smoke contains carcinogenic polycyclic aromatic hydrocarbons (PAHs), it was of interest to examine human cervical tissue for PAH-DNA adduct formation. Here, we measured PAH-DNA adduct formation in cervical biopsies collected in follow-up among women who tested positive for carcinogenic HPV at baseline. A semi-quantitative immunohistochemistry (IHC) method using antiserum elicited against DNA modified with r7,t8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) was used to measure nuclear PAH-DNA adduct formation. Cultured human cervical keratinocytes exposed to 0, 0.153, or 0.331 mu M BPDE showed dose-dependent increases in r7,t8,t9-trihydroxy-c-10-(N super(2)deoxyguanosyl)-7,8,9,10-tetrahydro-be nzo[a]pyrene (BPdG) adducts. For BPdG adduct analysis, paraffin-embedded keratinocytes were stained by IHC with analysis of nuclear color intensity by Automated Cellular Imaging System (ACIS) and, in parallel cultures, extracted DNA was assayed by quantitative BPDE-DNA chemiluminescence immunoassay (CIA). For paraffin-embedded samples from carcinogenic HPV-infected women, normal-appearing cervical squamous epithelium suitable for scoring was found in samples from 75 of the 114 individuals, including 29 cases of cervical precancer or cancer and 46 controls. With a lower limit of detection of 20 adducts/10 super(8) nucleotides, detectable PAH-DNA adduct values ranged from 25 to 191/10 super(8) nucleotides, with a median of 75/10 super(8) nucleotides. PAH-DNA adduct values above 150 /10 super(8) nucleotides were found in eight samples, and in three samples adducts were non-detectable. There was no correlation between PAH-DNA adduct formation and either smoking or case status. Therefore, PAH-DNA adduct formation as measured by this methodology did not appear related to the increased risk of cervical precancer and cancer among carcinogenic HPV-infected smokers. r7,t8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene (CAS No. 58917-67-2) r7,t8,t9-trihydroxy-c-10-(N super(2)deoxyguanosyl)-7,8,9,10-tetrahydro-be nzo[a]pyrene grouped together and included as the ''cases'' in this study epithelium were grouped together and included as ''controls'' in this study JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Pratt, M M AU - Sirajuddin, P AU - Poirier, M C AU - Schiffman, M AU - Glass, A G AU - Scott AU - Rush, B B AU - Olivero, O A AU - Castle, P E AD - LCBG, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA, prattm@mail.nih.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 114 EP - 123 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 624 IS - 1-2 SN - 1386-1964, 1386-1964 KW - Virology & AIDS Abstracts; Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Polycyclic aromatic hydrocarbons KW - Adducts KW - Biopsy KW - Cell culture KW - imaging KW - Cancer KW - Nucleotides KW - Mutagenesis KW - Color KW - Smoke KW - Smoking KW - DNA KW - Tobacco KW - Epithelium KW - Keratinocytes KW - Cervix KW - Chemiluminescence KW - Immunoassays KW - Immunohistochemistry KW - Aromatics KW - Benzo(a)pyrene-diol-epoxide KW - Human papillomavirus KW - X 24350:Industrial Chemicals KW - N 14810:Methods KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20395501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=Polycyclic+aromatic+hydrocarbon-DNA+adducts+in+cervix+of+women+infected+with+carcinogenic+human+papillomavirus+types%3A+An+immunohistochemistry+study&rft.au=Pratt%2C+M+M%3BSirajuddin%2C+P%3BPoirier%2C+M+C%3BSchiffman%2C+M%3BGlass%2C+A+G%3BScott%3BRush%2C+B+B%3BOlivero%2C+O+A%3BCastle%2C+P+E&rft.aulast=Pratt&rft.aufirst=M&rft.date=2007-11-01&rft.volume=624&rft.issue=1-2&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=13861964&rft_id=info:doi/10.1016%2Fj.mrfmmm.2007.04.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Polycyclic aromatic hydrocarbons; Adducts; Cell culture; Biopsy; imaging; Nucleotides; Cancer; Color; Mutagenesis; Smoke; Smoking; Tobacco; DNA; Epithelium; Keratinocytes; Chemiluminescence; Cervix; Immunohistochemistry; Immunoassays; Benzo(a)pyrene-diol-epoxide; Aromatics; Human papillomavirus DO - http://dx.doi.org/10.1016/j.mrfmmm.2007.04.008 ER - TY - JOUR T1 - Dietary Modulation of Colon Cancer Risk AN - 20376421; 7744985 AB - Colon cancer remains a significant global health concern. The impact of specific dietary components on colon tissue likely depends on a host of genomic processes that influence the growth, development, and differentiation of the epithelial cells at the colon crypt surface, where the balance between proliferation and differentiation is maintained possibly through the Wnt ({szligbeta}-catenin/T-cell factor) signaling pathway. A loss of balance caused by either genetic mutations or environmental factors such as dietary habits can modulate the risk for the formation of aberrant crypt foci and ultimately the development of colon cancer. Evidence exists that butyrate reduces the number and the size of aberrant crypt foci in the colon. Butyrate is a natural histone deacetylase inhibitor as well as a molecule involved with enhanced TGF-{szligbeta}-induced SMAD3 phosphorylation, increased IFN- gamma -mediated apoptosis, and altered expression of the intestinal muc2 gene that is responsible for mucin synthesis. Other dietary components, such as vitamin D and (n-3) fatty acids, may regulate proliferative properties of colon progenitor cells as well as the differentiation of subcellular lineages. Although these findings are intriguing, there are uncertainties that remain to be resolved including the optimal exposure needed to bring about an effect, the appropriate timing of administration, and if nutrient-nutrient and nutrient-gene interactions determine the overall response. The expanded use of high-throughput technologies, knowledge about the expression of genes and protein fingerprints, and metabolomic profiling will assist in addressing these issues and ultimately in determining the physiological significance of bioactive food components as cancer protectants. JF - Journal of Nutrition AU - Kim, Young S AU - Milner, John A AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2576S EP - 2579S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 137 IS - 11 SN - 0022-3166, 0022-3166 KW - Risk Abstracts KW - Diets KW - environmental factors KW - vitamins KW - mucins KW - Physiology KW - Fatty acids KW - Proteins KW - Mutation KW - Cancer KW - Technology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20376421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Dietary+Modulation+of+Colon+Cancer+Risk&rft.au=Kim%2C+Young+S%3BMilner%2C+John+A&rft.aulast=Kim&rft.aufirst=Young&rft.date=2007-11-01&rft.volume=137&rft.issue=11&rft.spage=2576S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; environmental factors; vitamins; mucins; Physiology; Fatty acids; Proteins; Mutation; Cancer; Technology ER - TY - JOUR T1 - New protein fold revealed by a 1.65 Aa resolution crystal structure of Francisella tularensis pathogenicity island protein IglC AN - 20374980; 7745927 AB - Francisella tularensis is a highly infectious Gram-negative intracellular pathogen that causes the fulminating disease tularemia and is considered to be a potential bioweapon. F. tularensis pathogenicity island proteins play a key role in modulating phagosome biogenesis and subsequent bacterial escape into the cytoplasm of macrophages. The 23 kDa pathogenicity island protein IglC is essential for the survival and proliferation of F. tularensis in macrophages. Seeking to gain some insight into its function, we determined the crystal structure of IglC at 1.65 Aa resolution. IglC adopts a beta -sandwich conformation that exhibits no similarity with any known protein structure. JF - Protein Science AU - Sun, Ping AU - Austin, Brian P AU - Schubot, Florian D AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702-1201, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2560 EP - 2563 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 11 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - pathogenicity islands KW - Macrophages KW - Cell survival KW - Protein structure KW - Tularemia KW - Protein folding KW - Cytoplasm KW - Phagosomes KW - Crystal structure KW - Francisella tularensis KW - Pathogens KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20374980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=New+protein+fold+revealed+by+a+1.65+Aa+resolution+crystal+structure+of+Francisella+tularensis+pathogenicity+island+protein+IglC&rft.au=Sun%2C+Ping%3BAustin%2C+Brian+P%3BSchubot%2C+Florian+D%3BWaugh%2C+David+S&rft.aulast=Sun&rft.aufirst=Ping&rft.date=2007-11-01&rft.volume=16&rft.issue=11&rft.spage=2560&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; Cell survival; Macrophages; pathogenicity islands; Tularemia; Protein folding; Cytoplasm; Phagosomes; Crystal structure; Pathogens; Francisella tularensis ER - TY - JOUR T1 - Ethnicity Is an Independent Correlate of Biomarkers of Micronutrient Intake and Status in American Adults AN - 20373169; 7744962 AB - Diet may be among the factors that mediate the acknowledged ethnicity and socioeconomic differentials in health. Biomarkers of nutritional exposure avoid reliance on biased self-reports of diet and allow an objective assessment of dietary differentials associated with ethnicity and socioeconomic position. We used data from the NHANES III (n = 13113) and NHANES 1999-2002 (n = 7246) to examine ethnic, education, and income differentials in serum concentrations of nutrients of putative public health importance (vitamins C, D, and E, folate, carotenoids, selenium, and ferritin) in U.S. adults. Multiple regression methods were used to adjust for covariates and complex survey design to examine these associations. The serum {szligbeta}-cryptoxanthin and lutein + zeaxanthin concentrations, adjusted for education and income, were higher in nonwhites (P < 0.0001) relative to non-Hispanic whites. Non-Hispanic blacks had lower serum vitamins C and D, folate, and selenium concentrations relative to non-Hispanic-whites. The biomarker profile (except vitamin D, and folate and ferritin in women) of Mexican-Americans was comparable or better relative to non-Hispanic-whites. Ethnicity associations with mean biomarker concentrations generally paralleled these associations with the proportion of the population at risk of marginal concentrations. Education was an independent positive predictor of serum concentrations of several carotenoids and vitamin C (P less than or equal to 0.01). Both education and income were independent inverse predictors of risk of marginal vitamin C concentration in men (P less than or equal to 0.003). Relative to income, ethnicity and education were stronger independent predictors of several outcomes. Ethnic differences in status of several micronutrients persisted after adjustment for education and income, suggesting the importance of ethnicity-specific nutrition interventions. JF - Journal of Nutrition AU - Kant, Ashima K AU - Graubard, Barry I AD - Department of Family, Nutrition, and Exercise Sciences, Queens College of the City University of New York, Flushing, NY 11367 and Division of Cancer Epidemiology and Genetics, Biostatistics Branch, National Cancer Institute, NIH, Bethesda, MD 20892 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2456 EP - 2463 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 137 IS - 11 SN - 0022-3166, 0022-3166 KW - Risk Abstracts KW - Bioindicators KW - Diets KW - micronutrients KW - Socioeconomics KW - Public health KW - nutrients KW - Selenium KW - USA KW - Education KW - vitamins KW - income KW - Ethnic groups KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20373169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Ethnicity+Is+an+Independent+Correlate+of+Biomarkers+of+Micronutrient+Intake+and+Status+in+American+Adults&rft.au=Kant%2C+Ashima+K%3BGraubard%2C+Barry+I&rft.aulast=Kant&rft.aufirst=Ashima&rft.date=2007-11-01&rft.volume=137&rft.issue=11&rft.spage=2456&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - nutrients; Diets; Bioindicators; Selenium; Education; vitamins; income; micronutrients; Socioeconomics; Ethnic groups; Public health; USA ER - TY - JOUR T1 - High-Affinity TCRs Generated by Phage Display Provide CD4 super(+) T Cells with the Ability to Recognize and Kill Tumor Cell Lines AN - 20331112; 7743330 AB - We examined the activity of human T cells engineered to express variants of a single TCR (1G4) specific for the cancer/testis Ag NY-ESO-1, generated by bacteriophage display with a wide range of affinities (from 4 mu M to 26 pM). CD8 super(+) T cells expressing intermediate- and high-affinity 1G4 TCR variants bound NY-ESO-1/HLA-A2 tetramers with high avidity and Ag specificity, but increased affinity was associated with a loss of target cell specificity of the TCR gene-modified cells. T cells expressing the highest affinity TCR (K sub(D) value of 26 pM) completely lost Ag specificity. The TCRs with affinities in the midrange, K sub(D) 5 and 85 nM, showed specificity only when CD8 was absent or blocked, while the variant TCRs with affinities in the intermediate range-with K sub(D) values of 450 nM and 4 mu M-demonstrated Ag-specific recognition. Although the biological activity of these two relatively low-affinity TCRs was comparable to wild-type reactivity in CD8 super(+) T cells, introduction of these TCR dramatically increased the reactivity of CD4 super(+) T cells to tumor cell lines. JF - Journal of Immunology AU - Zhao, Yangbing AU - Bennett, Alan D AU - Zheng, Zhili AU - Wang, Qiong J AU - Robbins, Paul F AU - Yu, Lawrence YL AU - Li, Yi AU - Molloy, Peter E AU - Dunn, Steven M AU - Jakobsen, Bent K AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Avidex Ltd., Abingdon, Oxon, United Kingdom Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 5845 EP - 5854 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 9 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Testes KW - Phages KW - Histocompatibility antigen HLA KW - double prime T-cell receptor KW - Phage display KW - CD8 antigen KW - Cancer KW - Tumor cell lines KW - CD4 antigen KW - NY-ESO-1 protein KW - Avidity KW - Lymphocytes T KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20331112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=High-Affinity+TCRs+Generated+by+Phage+Display+Provide+CD4+super%28%2B%29+T+Cells+with+the+Ability+to+Recognize+and+Kill+Tumor+Cell+Lines&rft.au=Zhao%2C+Yangbing%3BBennett%2C+Alan+D%3BZheng%2C+Zhili%3BWang%2C+Qiong+J%3BRobbins%2C+Paul+F%3BYu%2C+Lawrence+YL%3BLi%2C+Yi%3BMolloy%2C+Peter+E%3BDunn%2C+Steven+M%3BJakobsen%2C+Bent+K%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Zhao&rft.aufirst=Yangbing&rft.date=2007-11-01&rft.volume=179&rft.issue=9&rft.spage=5845&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Phages; Testes; CD4 antigen; Tumor cell lines; Avidity; NY-ESO-1 protein; double prime T-cell receptor; Phage display; Lymphocytes T; CD8 antigen; Cancer ER - TY - JOUR T1 - Immunization of Primates with a Newcastle Disease Virus-Vectored Vaccine via the Respiratory Tract Induces a High Titer of Serum Neutralizing Antibodies against Highly Pathogenic Avian Influenza Virus AN - 20330924; 7615849 AB - The ongoing outbreak of highly pathogenic avian influenza virus (HPAIV) in birds, the incidence of transmission to humans with a resulting high mortality rate, and the possibility of a human pandemic warrant the development of effective human vaccines against HPAIV. We developed an experimental live-attenuated vaccine for direct inoculation of the respiratory tract based on recombinant avian Newcastle disease virus (NDV) expressing the hemagglutinin (HA) glycoprotein of H5N1 HPAIV (NDV-HA). Expression of the HPAIV HA gene slightly reduced NDV virulence, as evidenced by the increased mean embryo death time and reduced replication in chickens. NDV-HA was administered to African green monkeys in two doses of 2 x 10 super(7) infectious units each with a 28-day interval to evaluate the systemic and local antibody responses specific to H5N1 HPAIV. The virus was shed only at low titers from the monkeys, indicative of safety. Two doses of NDV-HA induced a high titer of H5N1 HPAIV-neutralizing serum antibodies in all of the immunized monkeys. Moreover, a substantial mucosal immunoglobulin A response was induced in the respiratory tract after one and two doses. The titers of neutralizing antibodies achieved in this study suggest that the vaccine would be likely to prevent mortality and reduce morbidity caused by the H5N1 HPAIV. In addition, induction of a local immune response in the respiratory tract is an important advantage that is likely to reduce or prevent transmission of the virus during an outbreak or a pandemic. This vaccine is a candidate for clinical evaluation in humans. JF - Journal of Virology AU - DiNapoli, Joshua M AU - Yang, Lijuan AU - Suguitan, Amorsolo Jr AU - Elankumaran, Subbiah AU - Dorward, David W AU - Murphy, Brian R AU - Samal, Siba K AU - Collins, Peter L AU - Bukreyev, Alexander AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland 20742. Rocky Mountain Labs Research Technologies Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 11560 EP - 11568 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 21 SN - 0022-538X, 0022-538X KW - Primates KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Virology & AIDS Abstracts KW - Newcastle disease KW - Virulence KW - pandemics KW - Newcastle disease virus KW - Embryos KW - Glycoproteins KW - Respiratory tract KW - Replication KW - Immunization KW - Immunoglobulin A KW - Inoculation KW - Immune response KW - Vaccines KW - Avian influenza virus KW - Hemagglutinins KW - Mucosa KW - Morbidity KW - Disease transmission KW - Mortality KW - Fowl plague KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20330924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Immunization+of+Primates+with+a+Newcastle+Disease+Virus-Vectored+Vaccine+via+the+Respiratory+Tract+Induces+a+High+Titer+of+Serum+Neutralizing+Antibodies+against+Highly+Pathogenic+Avian+Influenza+Virus&rft.au=DiNapoli%2C+Joshua+M%3BYang%2C+Lijuan%3BSuguitan%2C+Amorsolo+Jr%3BElankumaran%2C+Subbiah%3BDorward%2C+David+W%3BMurphy%2C+Brian+R%3BSamal%2C+Siba+K%3BCollins%2C+Peter+L%3BBukreyev%2C+Alexander&rft.aulast=DiNapoli&rft.aufirst=Joshua&rft.date=2007-11-01&rft.volume=81&rft.issue=21&rft.spage=11560&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Avian influenza virus; Newcastle disease virus; Primates; Vaccines; Respiratory tract; Newcastle disease; Fowl plague; Mortality; Disease transmission; pandemics; Inoculation; Glycoproteins; Hemagglutinins; Embryos; Immune response; Virulence; Replication; Mucosa; Morbidity; Immunization; Immunoglobulin A ER - TY - JOUR T1 - Using Wireless Handheld Computers to Seek Information at the Point of Care: An Evaluation by Clinicians AN - 20324099; 7741757 AB - OBJECTIVE: To evaluate: (1) the effectiveness of wireless handheld computers for online information retrieval in clinical settings; (2) the role of MEDLINE registered in answering clinical questions raised at the point of care. DESIGN: A prospective single-cohort study: accompanying medical teams on teaching rounds, five internal medicine residents used and evaluated MD on Tap, an application for handheld computers, to seek answers in real time to clinical questions arising at the point of care. MEASUREMENTS: All transactions were stored by an intermediate server. Evaluators recorded clinical scenarios and questions, identified MEDLINE citations that answered the questions, and submitted daily and summative reports of their experience. A senior medical librarian corroborated the relevance of the selected citation to each scenario and question. RESULTS: Evaluators answered 68% of 363 background and foreground clinical questions during rounding sessions using a variety of MD on Tap features in an average session length of less than four minutes. The evaluator, the number and quality of query terms, the total number of citations found for a query, and the use of auto-spellcheck significantly contributed to the probability of query success. CONCLUSION: Handheld computers with Internet access are useful tools for healthcare providers to access MEDLINE in real time. MEDLINE citations can answer specific clinical questions when several medical terms are used to form a query. The MD on Tap application is an effective interface to MEDLINE in clinical settings, allowing clinicians to quickly find relevant citations. JF - Journal of the American Medical Informatics Association AU - Hauser, Susan E AU - Demner-Fushman, Dina AU - Jacobs, Joshua L AU - Humphrey, Susanne M AU - Ford, Glenn AU - Thoma, George R AD - Lister Hill National Center for Biomedical Communications, National Library of Medicine, National Institutes of Health, DHHS, Bethesda, MD. John A. Burns School of Medicine, University of Hawaii, Honolulu, HI Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 807 EP - 815 PB - American Medical Informatics Association, 4915 St. Elmo Ave. Suite 401 Bethesda MD 20814 USA, [mailto:mail@mail.amia.org], [URL:http://www.amia.org] VL - 14 IS - 6 SN - 1067-5027, 1067-5027 KW - Biotechnology and Bioengineering Abstracts KW - Information processing KW - Computers KW - Medical personnel KW - Internet KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20324099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Medical+Informatics+Association&rft.atitle=Using+Wireless+Handheld+Computers+to+Seek+Information+at+the+Point+of+Care%3A+An+Evaluation+by+Clinicians&rft.au=Hauser%2C+Susan+E%3BDemner-Fushman%2C+Dina%3BJacobs%2C+Joshua+L%3BHumphrey%2C+Susanne+M%3BFord%2C+Glenn%3BThoma%2C+George+R&rft.aulast=Hauser&rft.aufirst=Susan&rft.date=2007-11-01&rft.volume=14&rft.issue=6&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Medical+Informatics+Association&rft.issn=10675027&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Computers; Internet; Medical personnel; Information processing ER - TY - JOUR T1 - CD45-Positive Blood Cells Give Rise to Uterine Epithelial Cells in Mice AN - 20031474; 7746438 AB - The uterine endometrium is composed of epithelial and stromal cells, which undergo extensive degeneration and regeneration in every estrous cycle, and dramatic changes occur during pregnancy. The high turnover of cells requires a correspondingly high level of cell division by progenitor cells in the uterus, but the character and source of these cells remain obscure. In the present study, using a novel transgenic mouse, we showed that CD45-positive hematopoietic progenitor cells colonize the uterine epithelium and that in pregnancy more than 80% of the epithelium can derive from these cells. Since we also found green fluorescent protein (GFP)-positive uterine endothelial cells in long-term GFP bone marrow-transplanted mice, we conclude that circulating CD45+ cells play an important role in regenerating the uterine epithelium. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Bratincsak, Andras AU - Brownstein, Michael J AU - Cassiani-Ingoni, Riccardo AU - Pastorino, Sandra AU - Szalayova, Ildiko AU - Toth, Zsuzsanna E AU - Key, Sharon AU - Nemeth, Krisztian AU - Pickel, James AU - Mezey, Eva AD - National Institute of Mental Health, Bethesda, Maryland, USA. The J. Craig Venter Institute, Gaithersburg, Maryland, USA. National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA. National Cancer Institute, Bethesda, Maryland, USA. National Institute of Dental and Craniofacial Research, Bethesda, Maryland, USA. Department of Dermato-Venereology and Oncology, Semmelweis University, Budapest, Hungary Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2820 EP - 2826 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Epithelial cells KW - Endometrium KW - Uterus KW - stromal cells KW - Green fluorescent protein KW - Transgenic mice KW - Pregnancy KW - Endothelial cells KW - Cell division KW - Stem cells KW - Regeneration KW - Hemopoiesis KW - Degeneration KW - Epithelium KW - Blood cells KW - Estrus cycle KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20031474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=CD45-Positive+Blood+Cells+Give+Rise+to+Uterine+Epithelial+Cells+in+Mice&rft.au=Bratincsak%2C+Andras%3BBrownstein%2C+Michael+J%3BCassiani-Ingoni%2C+Riccardo%3BPastorino%2C+Sandra%3BSzalayova%2C+Ildiko%3BToth%2C+Zsuzsanna+E%3BKey%2C+Sharon%3BNemeth%2C+Krisztian%3BPickel%2C+James%3BMezey%2C+Eva&rft.aulast=Bratincsak&rft.aufirst=Andras&rft.date=2007-11-01&rft.volume=25&rft.issue=11&rft.spage=2820&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Uterus; Endometrium; stromal cells; Green fluorescent protein; Transgenic mice; Pregnancy; Endothelial cells; Stem cells; Cell division; Regeneration; Hemopoiesis; Epithelium; Degeneration; Blood cells; Estrus cycle ER - TY - JOUR T1 - Donor-Derived Human Bone Marrow Cells Contribute to Solid Organ Cancers Developing After Bone Marrow Transplantation AN - 20001318; 7746447 AB - Bone marrow-derived stem cells have been shown to participate in solid organ repair after tissue injury. Animal models suggest that epithelial malignancies may arise as aberrant stem cell differentiation during tissue repair. We hypothesized that if bone marrow stem cells participate in human neoplasia, then solid organ cancers developing after allogeneic bone marrow transplantation (ABMT) might include malignant cells of donor origin. We identified four male patients who developed solid organ cancers (lung adenocarcinoma, laryngeal squamous cell carcinoma, glioblastoma, and Kaposi sarcoma) after myeloablation, total body irradiation, and ABMT from female donors. Donor-derived malignant cells comprised 2.5%-6% of the tumor cellularity The presence of donor-derived malignant cells in solid organ cancers suggests that human bone marrow-derived stem cells have a role in solid organ cancer's carcinogenesis. However, the nature of this role is yet to be defined. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Avital, Itzhak AU - Moreira, Andre L AU - Klimstra, David S AU - Leversha, Margaret AU - Papadopoulos, Esperanza B AU - Brennan, Murray AU - Downey, Robert J AD - Surgery Branch, National Cancer Institute, Bethesda, Maryland, USA. Department of Pathology, Molecular Cytogenetics Core Facility, Department of Medicine, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2903 EP - 2909 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Glioblastoma KW - Bone cancer KW - Donors KW - Laryngeal cancer KW - Injuries KW - Bone marrow KW - Animal models KW - squamous cell carcinoma KW - Tumors KW - Neoplasia KW - Differentiation KW - Stem cells KW - Malignancy KW - Radiation KW - Carcinogenesis KW - Allografts KW - Sarcoma KW - Adenocarcinoma KW - Bone marrow transplantation KW - Lung cancer KW - W 30920:Tissue Engineering KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Donor-Derived+Human+Bone+Marrow+Cells+Contribute+to+Solid+Organ+Cancers+Developing+After+Bone+Marrow+Transplantation&rft.au=Avital%2C+Itzhak%3BMoreira%2C+Andre+L%3BKlimstra%2C+David+S%3BLeversha%2C+Margaret%3BPapadopoulos%2C+Esperanza+B%3BBrennan%2C+Murray%3BDowney%2C+Robert+J&rft.aulast=Avital&rft.aufirst=Itzhak&rft.date=2007-11-01&rft.volume=25&rft.issue=11&rft.spage=2903&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bone cancer; Glioblastoma; Laryngeal cancer; Donors; Injuries; Animal models; Bone marrow; squamous cell carcinoma; Tumors; Neoplasia; Differentiation; Malignancy; Stem cells; Radiation; Allografts; Carcinogenesis; Sarcoma; Adenocarcinoma; Bone marrow transplantation; Lung cancer ER - TY - JOUR T1 - Cyclic Tetrapyrrole Sulfonation, Metals, and Oligomerization in Antiprion Activity AN - 19998181; 7928029 AB - Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resistant prion protein were compared in several types of TSE-infected cell cultures. In addition, prophylactic antiscrapie activities were determined in scrapie-infected mice. The activity of phthalocyanine was relatively insensitive to the number of peripheral sulfonate groups but varied with the type of metal bound at the center of the molecule. The tendency of the various phthalocyanine sulfonates to oligomerize (i.e., stack) correlated with anti-TSE activity. Notably, aluminum(III) phthalocyanine tetrasulfonate was both the poorest anti-TSE compound and the least prone to oligomerization in aqueous media. Similar comparisons of iron- and manganese-bound porphyrin sulfonates confirmed that stacking ability correlates with anti-TSE activity among cyclic tetrapyrroles. JF - Antimicrobial Agents & Chemotherapy AU - Caughey, Winslow S AU - Priola, Suzette A AU - Kocisko, David A AU - Raymond, Lynne D AU - Ward, Anne AU - Caughey, Byron AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana 59840 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 3887 EP - 3894 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts KW - Transmissible spongiform encephalopathy KW - Metals KW - Porphyrins KW - Media (differential) KW - Stacking KW - Sulfonation KW - Oligomerization KW - Prion protein KW - tetrapyrroles KW - Cell culture KW - A 01340:Antibiotics & Antimicrobials KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19998181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Cyclic+Tetrapyrrole+Sulfonation%2C+Metals%2C+and+Oligomerization+in+Antiprion+Activity&rft.au=Caughey%2C+Winslow+S%3BPriola%2C+Suzette+A%3BKocisko%2C+David+A%3BRaymond%2C+Lynne+D%3BWard%2C+Anne%3BCaughey%2C+Byron&rft.aulast=Caughey&rft.aufirst=Winslow&rft.date=2007-11-01&rft.volume=51&rft.issue=11&rft.spage=3887&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Porphyrins; Metals; Media (differential); Stacking; Oligomerization; Sulfonation; Prion protein; tetrapyrroles; Cell culture ER - TY - JOUR T1 - Three-dimensional microenvironments modulate fibroblast signaling responses AN - 19913250; 8768016 AB - Modes of signaling in fibroblasts can differ substantially depending on whether these cells are in their natural three-dimensional environment compared to artificial two-dimensional culture conditions. Although studying cell behavior in two-dimensional environments has been valuable for understanding biological processes, questions can be raised about their in vivo physiological relevance. This review focuses on some of our research involving fibroblast behavior in cell-derived three-dimensional matrices. Specifically, we examine how these matrices affect cell morphology, adhesion, proliferation, and signaling compared to two-dimensional substrates. We stress the importance of controls for three-dimensional matrix studies and discuss cancer as an example in which altered three-dimensional matrices can influence fibroblast signaling. Studying cells in three-dimensional microenvironments can lead to the design of more physiologically relevant conditions for assaying drug responses and deciphering biological mechanisms. JF - Advanced Drug Delivery Reviews AU - Green, JAngelo AU - Yamada, Kenneth M AD - Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, MSC 4370, Bethesda, MD 20892, USA, kenneth.yamada@nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1293 EP - 1298 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 59 IS - 13 SN - 0169-409X, 0169-409X KW - Biotechnology and Bioengineering Abstracts KW - Drug delivery KW - Cytology KW - Microenvironments KW - Cell culture KW - Drug development KW - Cancer KW - Fibroblasts KW - Signal transduction KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19913250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advanced+Drug+Delivery+Reviews&rft.atitle=Three-dimensional+microenvironments+modulate+fibroblast+signaling+responses&rft.au=Green%2C+JAngelo%3BYamada%2C+Kenneth+M&rft.aulast=Green&rft.aufirst=JAngelo&rft.date=2007-11-01&rft.volume=59&rft.issue=13&rft.spage=1293&rft.isbn=&rft.btitle=&rft.title=Advanced+Drug+Delivery+Reviews&rft.issn=0169409X&rft_id=info:doi/10.1016%2Fj.addr.2007.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Signal transduction; Fibroblasts; Drug development; Microenvironments; Cell culture; Drug delivery; Cancer; Cytology DO - http://dx.doi.org/10.1016/j.addr.2007.08.005 ER - TY - JOUR T1 - AID-deficient Bcl-xL transgenic mice develop delayed atypical plasma cell tumors with unusual Ig/Myc chromosomal rearrangements AN - 19896570; 7742961 AB - Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) class switch recombination and somatic hypermutation, and has also been implicated in translocations between Ig switch regions and c-Myc in plasma cell tumors in mice. We asked if AID is required for accelerated tumor development in pristane-treated Bcl-xL transgenic BALB/c mice deficient in AID (pBxAicda-/-). pBxAicda super(-/-) mice developed tumors with a lower frequency (24 vs. 62%) and a longer mean latency (108 vs. 36 d) than AID-sufficient mice. The tumors appeared in oil granuloma tissue and did not form ascites. By interphase fluorescence in situ hybridization, six out of nine pBxAicda super(-/-) primary tumors had T(12; 15) and one had T(6; 15) chromosomal translocations. Two tumors were transplantable and established as stable cell lines. Molecular and cytogenetic analyses showed that one had an unusual unbalanced T(12; 15) translocation, with IgH C mu and Pvt-1 oriented head to tail at the breakpoint, resulting in an elevated expression of c-Myc. In contrast, the second was T(12; 15) negative, but had an elevated N-Myc expression caused by a paracentric inversion of chromosome 12. Thus, novel mechanisms juxtapose Ig and Myc-family genes in AID-deficient plasma cell tumors. JF - Journal of Experimental Medicine AU - Kovalchuk, Alexander L AU - duBois, Wendy AU - Mushinski, Elizabeth AU - McNeil, Nicole E AU - Hirt, Carsten AU - Qi, Chen-Feng AU - Li, Zhaoyang AU - Janz, Siegfried AU - Honjo, Tasuku AU - Muramatsu, Masamichi AU - Ried, Thomas AU - Behrens, Timothy AU - Potter, Michael AD - Laboratory of Cancer Biology and Genetics, Genetics Branch, Cancer Genomics Section, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892. Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852. Department of Pathology, University of Iowa, Carver Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242. Department of Immunology and Genomic Medicine, Kyoto University, Graduate School of Medicine, Kyoto 606-8501, Japan. Department of Molecular Genetics, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan. Genentech, Inc., South San Francisco, CA 94080 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2989 EP - 3001 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 12 SN - 0022-1007, 0022-1007 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Class switching KW - Activation-induced cytidine deaminase KW - Chromosome 12 KW - Oil KW - Myc protein KW - Recombination KW - Bcl-x protein KW - Breakpoints KW - Chromosome rearrangements KW - c-Myc protein KW - Immunoglobulins KW - Fluorescence in situ hybridization KW - Head KW - Tails KW - Interphase KW - Tumors KW - Granuloma KW - Transgenic mice KW - Chromosome translocations KW - Ascites KW - Inversion KW - somatic hypermutation KW - Plasma cells KW - Heavy chains KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle KW - W 30945:Fermentation & Cell Culture UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19896570?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=AID-deficient+Bcl-xL+transgenic+mice+develop+delayed+atypical+plasma+cell+tumors+with+unusual+Ig%2FMyc+chromosomal+rearrangements&rft.au=Kovalchuk%2C+Alexander+L%3BduBois%2C+Wendy%3BMushinski%2C+Elizabeth%3BMcNeil%2C+Nicole+E%3BHirt%2C+Carsten%3BQi%2C+Chen-Feng%3BLi%2C+Zhaoyang%3BJanz%2C+Siegfried%3BHonjo%2C+Tasuku%3BMuramatsu%2C+Masamichi%3BRied%2C+Thomas%3BBehrens%2C+Timothy%3BPotter%2C+Michael&rft.aulast=Kovalchuk&rft.aufirst=Alexander&rft.date=2007-11-01&rft.volume=204&rft.issue=12&rft.spage=2989&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Head; Tails; Class switching; Interphase; Activation-induced cytidine deaminase; Tumors; Transgenic mice; Granuloma; Chromosome 12; Myc protein; Oil; Breakpoints; Bcl-x protein; Recombination; Chromosome translocations; Inversion; Ascites; Chromosome rearrangements; somatic hypermutation; Heavy chains; Plasma cells; c-Myc protein; Fluorescence in situ hybridization; Immunoglobulins ER - TY - JOUR T1 - Improving health profile of blood donors as a consequence of transfusion safety efforts AN - 19797653; 8008476 AB - BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had an overall mortality 30 percent lower (99% confidence interval [lsqb]CI[rsqb] 29%-31%) and cancer incidence 4 percent lower (99% CI 2%-5%) than the background population. Mortality rates and cancer incidence were lowest for outcomes that are recognized as being related to lifestyle factors such as smoking or to the selection criteria for blood donation. Blood donors recruited in more recent years exhibited a lower relative mortality than those who started earlier. CONCLUSION: Blood donors enjoy better than average health. Explicit and informal requirements for blood donation in Scandinavia, although mostly of a simple nature, have successfully refined the selection of a particularly healthy subpopulation. JF - Transfusion AU - Edgren, Gustaf AU - Tran, Trung Nam AU - Hjalgrim, Henrik AU - Rostgaard, Klaus AU - Shanwell, Agneta AU - Titlestad, Kjell AU - Wikman, Agneta AU - Norda, Rut AU - Jersild, Casper AU - Wideroff, Louise AU - Gridley, Gloria AU - Adami, Johanna AU - Melbye, Mads AU - Nyren, Olof AU - Reilly, Marie AD - From the Department of Medical Epidemiology and Biostatistics and the Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden; the Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark; the Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden; the Department of Clinical Immunology, Odense University Hospital, Odense, Denmark; the Department of Immunology and Transfusion Medicine, Akademiska University Hospital, Uppsala, Sweden; the Department of Clinical Immunology, Arhus University Hospital, Arhus, Denmark; and Division of Cancer Control and Population Sciences and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland., olof.nyren@ki.se Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 2017 EP - 2024 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 47 IS - 11 SN - 0041-1132, 0041-1132 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Mortality KW - Blood donors KW - Smoking KW - Scandinavia KW - Blood transfusion KW - safety engineering KW - Denmark KW - emigration KW - Cancer KW - Sweden KW - H 13000:Medical Safety KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19797653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Improving+health+profile+of+blood+donors+as+a+consequence+of+transfusion+safety+efforts&rft.au=Edgren%2C+Gustaf%3BTran%2C+Trung+Nam%3BHjalgrim%2C+Henrik%3BRostgaard%2C+Klaus%3BShanwell%2C+Agneta%3BTitlestad%2C+Kjell%3BWikman%2C+Agneta%3BNorda%2C+Rut%3BJersild%2C+Casper%3BWideroff%2C+Louise%3BGridley%2C+Gloria%3BAdami%2C+Johanna%3BMelbye%2C+Mads%3BNyren%2C+Olof%3BReilly%2C+Marie&rft.aulast=Edgren&rft.aufirst=Gustaf&rft.date=2007-11-01&rft.volume=47&rft.issue=11&rft.spage=2017&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2007.01425.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smoking; Blood donors; Mortality; safety engineering; Blood transfusion; emigration; Cancer; Scandinavia; Denmark; Sweden DO - http://dx.doi.org/10.1111/j.1537-2995.2007.01425.x ER - TY - JOUR T1 - Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study AN - 19787129; 7608806 AB - Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance. JF - American Journal of Epidemiology AU - Bonner, Matthew R AU - Coble, Joseph AU - Blair, Aaron AU - Beane Freeman, Laura E AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael CR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1023 EP - 1034 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 166 IS - 9 SN - 0002-9262, 0002-9262 KW - Risk Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts KW - Inventories KW - Organophosphates KW - melanoma KW - organophosphates KW - Agrochemicals KW - Malathion KW - Cancer KW - Melanoma KW - Non-Hodgkin's lymphoma KW - USA KW - Insecticides KW - Carcinogenicity KW - Pesticides KW - lymphoma KW - rodents KW - H 5000:Pesticides KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Malathion+Exposure+and+the+Incidence+of+Cancer+in+the+Agricultural+Health+Study&rft.au=Bonner%2C+Matthew+R%3BCoble%2C+Joseph%3BBlair%2C+Aaron%3BBeane+Freeman%2C+Laura+E%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+CR&rft.aulast=Bonner&rft.aufirst=Matthew&rft.date=2007-11-01&rft.volume=166&rft.issue=9&rft.spage=1023&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inventories; Non-Hodgkin's lymphoma; Insecticides; Carcinogenicity; Pesticides; organophosphates; Cancer; Malathion; Melanoma; Organophosphates; melanoma; Agrochemicals; lymphoma; rodents; USA ER - TY - JOUR T1 - The bacteriophage P1 hot gene, encoding a homolog of the E. coli DNA polymerase III psi subunit, is expressed during both lysogenic and lytic growth stages AN - 19738429; 7785979 AB - The bacteriophage P1 hot gene product is a homolog of the psi subunit of E. coli DNA polymerase III. Previous studies with hot cloned on a plasmid have shown that Hot protein can substitute for psi , as evidenced by its stabilizing effect on certain dnaQ mutator mutants carrying an unstable pol III proofreading subunit ( approximately equal to subunit). These results are consistent with Hot, like psi , being a replication protein involved in stabilizing the intrinsically unstable approximately equal to proofreading function. However, the function of hot for the viral life cycle is less clear. In the present study, we show that the hot gene is not essential. Based on its promoter structure, hot has been previously classified as a ''late'' phage gene, a property that is not easily reconciled with a presumed replication function. Here, we clarify this issue by demonstrating that P1 hot is actively expressed both during the lysogenic state and in the early stages of a lytic induction, in addition to its expression in the late stage of phage development. The results indicate that P1 hot has a complex expression pattern, compatible with a model in which Hot may affect the host replication machinery to benefit overall phage replication. JF - Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis AU - Chikova, A K AU - Schaaper, R M AD - National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA, schaaper@niehs.nih.gov Y1 - 2007/11/01/ PY - 2007 DA - 2007 Nov 01 SP - 1 EP - 8 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 624 IS - 1-2 SN - 1386-1964, 1386-1964 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Genetics Abstracts KW - Phages KW - Molecular modelling KW - Replication KW - Life cycle KW - Developmental stages KW - Growth stage KW - Plasmids KW - Proofreading KW - Models KW - Mutagenesis KW - Promoters KW - DNA-directed DNA polymerase KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association KW - V 22310:Genetics, Taxonomy & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19738429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.atitle=The+bacteriophage+P1+hot+gene%2C+encoding+a+homolog+of+the+E.+coli+DNA+polymerase+III+psi+subunit%2C+is+expressed+during+both+lysogenic+and+lytic+growth+stages&rft.au=Chikova%2C+A+K%3BSchaaper%2C+R+M&rft.aulast=Chikova&rft.aufirst=A&rft.date=2007-11-01&rft.volume=624&rft.issue=1-2&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Fundamental+and+Molecular+Mechanisms+of+Mutagenesis&rft.issn=13861964&rft_id=info:doi/10.1016%2Fj.mrfmmm.2007.01.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Molecular modelling; Promoters; Replication; DNA-directed DNA polymerase; Developmental stages; Life cycle; Growth stage; Plasmids; Mutagenesis; Models; Proofreading; Escherichia coli DO - http://dx.doi.org/10.1016/j.mrfmmm.2007.01.014 ER - TY - JOUR T1 - Structure and activity of Yersinia pestis 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase as a novel target for the development of antiplague therapeutics AN - 19680225; 8055664 AB - 6-Hydroxymethyl-7,8-dihydropterin pyrophosphokinase (HPPK) is a key enzyme in the folate-biosynthetic pathway and is essential for microorganisms but absent from mammals. HPPK catalyzes Mg super(2+)-dependent pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). Previously, three-dimensional structures of Escherichia coli HPPK (EcHPPK) have been determined at almost every stage of its catalytic cycle and the reaction mechanism has been established. Here, the crystal structure of Yersinia pestis HPPK (YpHPPK) in complex with HP and an ATP analog is presented together with thermodynamic and kinetic characterizations. The two HPPK molecules differ significantly in a helix-loop area ( alpha 2-Lp3). YpHPPK has lower affinities than EcHPPK for both nucleotides and HP, but its rate constants for the mechanistic steps of both chemical transformation and product release are comparable with those of EcHPPK. Y. pestis, which causes plague, is a category A select agent according to the Centers for Disease Control and Prevention (CDC). Therefore, these structural and biochemical data are valuable for the design of novel medical countermeasures against plague. JF - Acta Crystallographica Section D AU - Blaszczyk, Jaroslaw AU - Li, Yue AU - Cherry, Scott AU - Alexandratos, Jerry AU - Wu, Yan AU - Shaw, Gary AU - Tropea, Joseph E AU - Waugh, David S AU - Yan, Honggao AU - Ji, Xinhua AD - Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA, yanh@msu.edu Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1169 EP - 1177 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 63 IS - 11 SN - 0907-4449, 0907-4449 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase KW - HPPK KW - Yersinia pestis KW - antiplague targets. KW - Transformation KW - Data processing KW - Thermodynamics KW - Disease control KW - Enzymes KW - ATP KW - Drug development KW - Nucleotides KW - Reaction mechanisms KW - Kinetics KW - Escherichia coli KW - Microorganisms KW - Crystal structure KW - Plague KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - J 02310:Genetics & Taxonomy KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19680225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Crystallographica+Section+D&rft.atitle=Structure+and+activity+of+Yersinia+pestis+6-hydroxymethyl-7%2C8-dihydropterin+pyrophosphokinase+as+a+novel+target+for+the+development+of+antiplague+therapeutics&rft.au=Blaszczyk%2C+Jaroslaw%3BLi%2C+Yue%3BCherry%2C+Scott%3BAlexandratos%2C+Jerry%3BWu%2C+Yan%3BShaw%2C+Gary%3BTropea%2C+Joseph+E%3BWaugh%2C+David+S%3BYan%2C+Honggao%3BJi%2C+Xinhua&rft.aulast=Blaszczyk&rft.aufirst=Jaroslaw&rft.date=2007-11-01&rft.volume=63&rft.issue=11&rft.spage=1169&rft.isbn=&rft.btitle=&rft.title=Acta+Crystallographica+Section+D&rft.issn=09074449&rft_id=info:doi/10.1107%2FS0907444907047452 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Transformation; Data processing; Thermodynamics; Disease control; ATP; Enzymes; Drug development; Nucleotides; Reaction mechanisms; Kinetics; Crystal structure; Microorganisms; Plague; Escherichia coli; Yersinia pestis DO - http://dx.doi.org/10.1107/S0907444907047452 ER - TY - JOUR T1 - GST genotypes and lung cancer susceptibility in Asian populations with indoor air pollution exposures: A meta-analysis AN - 19648333; 7939066 AB - About half of the world's population is exposed to smoke from heating or cooking with coal, wood, or biomass. These exposures, and fumes from cooking oil use, have been associated with increased lung cancer risk. Glutathione S-transferases play an important role in the detoxification of a wide range of human carcinogens in these exposures. Functional polymorphisms have been identified in the GSTM1, GSTT1, and GSTP1 genes, which may alter the risk of lung cancer among individuals exposed to coal, wood, and biomass smoke, and cooking oil fumes. We performed a meta-analysis of 6 published studies (912 cases; 1063 controls) from regions in Asia where indoor air pollution makes a substantial contribution to lung cancer risk, and evaluated the association between the GSTM1 null, GSTT1 null, and GSTP1 105Val polymorphisms and lung cancer risk. Using a random effects model, we found that carriers of the GSTM1 null genotype had a borderline significant increased lung cancer risk (odds ratio (OR), 1.31; 95% confidence interval (CI), 0.95-1.79; p=0.10), which was particularly evident in the summary risk estimate for the four studies carried out in regions of Asia that use coal for heating and cooking (OR, 1.64; 95% CI, 1.25-2.14; p=0.0003). The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95% CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele. Previous meta- and pooled-analyses suggest at most a small association between the GSTM1 null genotype and lung cancer risk in populations where the vast majority of lung cancer is attributed to tobacco, and where indoor air pollution from domestic heating and cooking is much less than in developing Asian countries. Our results suggest that the GSTM1 null genotype may be associated with a more substantial risk of lung cancer in populations with coal exposure. JF - Mutation Research-Reviews in Mutation Research AU - Hosgood, H D AU - Berndt, SI AU - Lan, Q AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, 6120 Executive Blvd., EPS 8118, MCS 7240, Bethesda, MD 20892-7240, United States, hosgoodd@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 134 EP - 143 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 636 IS - 1-3 SN - 1383-5742, 1383-5742 KW - Pollution Abstracts; Genetics Abstracts; Toxicology Abstracts KW - Detoxification KW - GSTT1 protein KW - Indoor air pollution KW - Gene polymorphism KW - Genotypes KW - Coal KW - Carcinogens KW - Glutathione transferase KW - Models KW - Oil KW - world population KW - GSTM1 protein KW - Cooking KW - Tobacco KW - cooking KW - Asia KW - Lung cancer KW - Fumes KW - Wood KW - Biomass KW - Cancer KW - Smoke KW - Air pollution KW - Reviews KW - Mutation KW - P 0000:AIR POLLUTION KW - G 07710:Chemical Mutagenesis & Radiation KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19648333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+Research-Reviews+in+Mutation+Research&rft.atitle=GST+genotypes+and+lung+cancer+susceptibility+in+Asian+populations+with+indoor+air+pollution+exposures%3A+A+meta-analysis&rft.au=Hosgood%2C+H+D%3BBerndt%2C+SI%3BLan%2C+Q&rft.aulast=Hosgood&rft.aufirst=H&rft.date=2007-11-01&rft.volume=636&rft.issue=1-3&rft.spage=134&rft.isbn=&rft.btitle=&rft.title=Mutation+Research-Reviews+in+Mutation+Research&rft.issn=13835742&rft_id=info:doi/10.1016%2Fj.mrrev.2007.02.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Detoxification; GSTT1 protein; Fumes; Gene polymorphism; Carcinogens; Coal; Glutathione transferase; Biomass; Models; Air pollution; Smoke; Oil; GSTM1 protein; Reviews; Cooking; Tobacco; Lung cancer; Indoor air pollution; Wood; Genotypes; Cancer; world population; cooking; Mutation; Asia DO - http://dx.doi.org/10.1016/j.mrrev.2007.02.002 ER - TY - JOUR T1 - Targeting to the endoplasmic reticulum improves the folding of recombinant human telomerase reverse transcriptase AN - 19606064; 8601690 AB - Telomerase is a specialized reverse transcriptase that catalyzes the addition of telomeric repeats, TTAGGG in all vertebrates, to the ends of chromosomes. The lack of recombinant purified human telomerase reverse transcriptase (hTERT) has hampered biochemical and structural studies. The primary problem in generating active recombinant hTERT appears to be protein folding, which may be due to the fact that telomerase is a multi-component ribonucleoprotein complex. When expressed in most heterologous systems, recombinant hTERT is largely insoluble. Here we describe a protein expression system using a baculovirus vector that can be used to prepare properly folded, enzymatically active, hTERT. In this system, the recombinant hTERT is directed to the endoplasmic reticulum (ER), which is rich in chaperones. This increases the expression of soluble recombinant hTERT, promoting proper folding using intrinsic ER chaperone proteins. JF - Protein Expression and Purification AU - Wu, Chia-Kuei AU - Gousset, Karine AU - Hughes, Stephen H AD - HIV Drug Resistance Program, National Cancer Institute at Frederick, P.O. Box B, Building 539, Room 130A, Frederick, MD 21702-1201, USA, hughes@ncifcrf.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 8 EP - 19 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 56 IS - 1 SN - 1046-5928, 1046-5928 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Human telomerase reverse transcriptase KW - Protein folding KW - Chaperone KW - Endoplasmic reticulum KW - Co-translational KW - Expression vectors KW - Chromosomes KW - Ribonucleoproteins KW - RNA-directed DNA polymerase KW - Chaperones KW - telomerase reverse transcriptase KW - protein purification KW - Baculovirus KW - W 30905:Medical Applications KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19606064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Targeting+to+the+endoplasmic+reticulum+improves+the+folding+of+recombinant+human+telomerase+reverse+transcriptase&rft.au=Wu%2C+Chia-Kuei%3BGousset%2C+Karine%3BHughes%2C+Stephen+H&rft.aulast=Wu&rft.aufirst=Chia-Kuei&rft.date=2007-11-01&rft.volume=56&rft.issue=1&rft.spage=8&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2007.05.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Endoplasmic reticulum; Chromosomes; Protein folding; Ribonucleoproteins; RNA-directed DNA polymerase; Chaperones; protein purification; telomerase reverse transcriptase; Baculovirus DO - http://dx.doi.org/10.1016/j.pep.2007.05.016 ER - TY - JOUR T1 - Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system AN - 19527172; 8029097 AB - Background The versatility of recombinant adeno-associated vector (rAAV) as a gene delivery system is due to the vector's ability to transduce different cell types as well as dividing and non-dividing cells. Large-scale production of rAAV remains one of the major challenges for continued development of pre-clinical and clinical studies, and for its potential commercialization. The baculovirus expression vectors (BEVS) and insect cells represent a potential method to produce rAAV economically at large scale. This technology uses three different BEVs (Bac-Rep, Bac-GFP, and Bac-VP) each at a multiplicity of infection (MOI) of 3. We reported previously the production of rAAV at 40 L scale using a stirred-tank bioreactor (STB). However, production in larger volumes is limited by the stability of the BEVs and amount of BEVs needed to achieve the target MOI of 3 per BEV. Here, the production parameters were optimized and the baculovirus stability was determined. Methods The stability of the three types of baculovirus used to produce rAAV was determined for six expansion passages by protein expression analysis. To economize baculovirus, MOI and cell density at time of infection (TOI) were evaluated initially at small scale and then applied to the 10 L scale. Results An MOI = 0.03 and TOI cell density of 1 X 106 cells/mL produced high titer rAAV without comprising yield. To confirm the scalability of the process, rAAV was produced in a 10 L STB using the optimized parameters obtaining a 10X increase in yield (1 X 1014 rAAV DNAse-resistant particles per liter). Conclusion These findings contribute to the process development for large-scale production of rAAV for gene therapy applications and its commercialization. JF - Journal of Gene Medicine AU - Negrete, Alejandro AU - Yang, Linda C AU - Mendez, Andres F AU - Levy, Justin R AU - Kotin, Robert M AD - Laboratory of Biochemical Genetics, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD 20892, USA, kotinr@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 938 EP - 948 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 9 IS - 11 SN - 1099-498X, 1099-498X KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Expression vectors KW - Gene therapy KW - Bioreactors KW - Insect cells KW - Cell density KW - Baculovirus KW - Multiplicity of infection KW - W 30905:Medical Applications KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19527172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Gene+Medicine&rft.atitle=Economized+large-scale+production+of+high+yield+of+rAAV+for+gene+therapy+applications+exploiting+baculovirus+expression+system&rft.au=Negrete%2C+Alejandro%3BYang%2C+Linda+C%3BMendez%2C+Andres+F%3BLevy%2C+Justin+R%3BKotin%2C+Robert+M&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2007-11-01&rft.volume=9&rft.issue=11&rft.spage=938&rft.isbn=&rft.btitle=&rft.title=Journal+of+Gene+Medicine&rft.issn=1099498X&rft_id=info:doi/10.1002%2Fjgm.1092 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Gene therapy; Insect cells; Bioreactors; Cell density; Multiplicity of infection; Baculovirus DO - http://dx.doi.org/10.1002/jgm.1092 ER - TY - JOUR T1 - Production of recombinant adeno-associated vectors using two bioreactor configurations at different scales AN - 19471483; 8242351 AB - The conventional methods for producing recombinant adeno-associated virus (rAAV) rely on transient transfection of adherent mammalian cells. To gain acceptance and achieve current good manufacturing process (cGMP) compliance, clinical grade rAAV production process should have the following qualities: simplicity, consistency, cost effectiveness, and scalability. Currently, the only viable method for producing rAAV in large-scale, e.g. >=10 super(1) super(6) particles per production run, utilizes baculovirus expression vectors (BEVs) and insect cells suspension cultures. The previously described rAAV production in 40L culture using a stirred tank bioreactor requires special conditions for implementation and operation not available in all laboratories. Alternatives to producing rAAV in stirred tank bioreactors are single-use, disposable bioreactors, e.g. Wave(TM). The disposable bags are purchased pre-sterilized thereby eliminating the need for end-user sterilization and also avoiding cleaning steps between production runs thus facilitating the production process. In this study, rAAV production in stirred tank and Wave(TM) bioreactors was compared. The working volumes were 10L and 40L for the stirred tank bioreactors and 5L and 20L for the Wave(TM) bioreactors. Comparable yields of rAAV, arrow up E+13 particles per liter of cell culture were obtained in all volumes and configurations. These results demonstrate that producing rAAV in large scale using BEVs is reproducible, scalable, and independent of the bioreactor configuration. JF - Journal of Virological Methods AU - Negrete, A AU - Kotin, R M AD - National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, MD 20892, USA, kotinr@mail.nih.gov Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 155 EP - 161 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 145 IS - 2 SN - 0166-0934, 0166-0934 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Cyclic GMP KW - Expression vectors KW - Mammalian cells KW - Transfection KW - Bioreactors KW - Insect cells KW - Cell culture KW - Suspension culture KW - Baculovirus KW - Adeno-associated virus KW - Sterilization KW - V 22300:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19471483?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virological+Methods&rft.atitle=Production+of+recombinant+adeno-associated+vectors+using+two+bioreactor+configurations+at+different+scales&rft.au=Negrete%2C+A%3BKotin%2C+R+M&rft.aulast=Negrete&rft.aufirst=A&rft.date=2007-11-01&rft.volume=145&rft.issue=2&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virological+Methods&rft.issn=01660934&rft_id=info:doi/10.1016%2Fj.jviromet.2007.05.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Cyclic GMP; Mammalian cells; Transfection; Insect cells; Bioreactors; Suspension culture; Cell culture; Sterilization; Baculovirus; Adeno-associated virus DO - http://dx.doi.org/10.1016/j.jviromet.2007.05.020 ER - TY - JOUR T1 - Mirabamides A--D, Depsipeptides from the Sponge Siliquariaspongia mirabilis That Inhibit HIV-1 Fusion AN - 19308573; 8429861 AB - Four new cyclic depsipeptides termed mirabamides A--D (1--4) have been isolated from the marine sponge Siliquariaspongia mirabilis and shown to potently inhibit HIV-1 fusion. Their structures were elucidated by NMR and ESIMS, and absolute stereochemistry of the amino acids was determined using advanced Marfey's methods and NMR. Mirabamides contain two new entities, including 4-chlorohomoproline in 1--3 and an unusual glycosylated amino acid, b-methoxytyrosine 4'-O-a-L-rhamnopyranoside (in 1,2, and 4), along with a rare N-terminal aliphatic hydroxy acid. These elements proved to be useful for anti-HIV structure-activity relationship studies. Mirabamide A inhibited HIV-1 in neutralization and fusion assays with IC sub(50) values between 40 and 140 nM, as did mirabamides C and D (IC sub(50) values between 140 nM and 1.3 kM for 3 and 190 nM and 3.9 kM for 4), indicating that these peptides can act at the early stages of HIV-1 entry. The potent activity of depsipeptides containing the glycosylated b-OMe Tyr unit demonstrates that b-OMe Tyr itself is not critical for activity. Mirabamides A--C inhibited the growth of B. subtilis and C. albicans at 1--5 kg/disk in disk diffusion assays. JF - Journal of Natural Products AU - Plaza, A AU - Gustchina, E AU - Baker, H L AU - Kelly, M AU - Bewley, CA AD - Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0820 Y1 - 2007/11// PY - 2007 DA - Nov 2007 SP - 1753 EP - 1760 VL - 70 IS - 11 SN - 0163-3864, 0163-3864 KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; ASFA Marine Biotechnology Abstracts; ASFA 1: Biological Sciences & Living Resources KW - Molecular structure KW - Amino acids KW - Marine invertebrates KW - Pharmacology KW - Siliquariaspongia mirabilis KW - natural products KW - Metabolites KW - Stereochemistry KW - Human immunodeficiency virus KW - Aquatic drugs KW - Human immunodeficiency virus 1 KW - N.M.R. KW - Diffusion KW - Peptides KW - Structure-activity relationships KW - A 01340:Antibiotics & Antimicrobials KW - Q4 27740:Products KW - Q1 08625:Non-edible products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19308573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=Mirabamides+A--D%2C+Depsipeptides+from+the+Sponge+Siliquariaspongia+mirabilis+That+Inhibit+HIV-1+Fusion&rft.au=Plaza%2C+A%3BGustchina%2C+E%3BBaker%2C+H+L%3BKelly%2C+M%3BBewley%2C+CA&rft.aulast=Plaza&rft.aufirst=A&rft.date=2007-11-01&rft.volume=70&rft.issue=11&rft.spage=1753&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp070306k LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Molecular structure; Marine invertebrates; Pharmacology; Aquatic drugs; Metabolites; Peptides; Amino acids; Diffusion; natural products; N.M.R.; Structure-activity relationships; Stereochemistry; Human immunodeficiency virus; Human immunodeficiency virus 1; Siliquariaspongia mirabilis DO - http://dx.doi.org/10.1021/np070306k ER - TY - JOUR T1 - Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. AN - 68472250; 17978044 AB - The hippocampus is critical for some forms of memory and spatial navigation, but previous research has mostly neglected the CA2, a unique region situated between CA3 and CA1. Here, we show that CA2 pyramidal neurons have distinctive physiological characteristics that include an unprecedented synaptic stability. Although basal synaptic currents in CA1 and CA2 are quite similar, synaptic plasticity including long-term potentiation and long-term depression is absent or less likely to be induced with conventional methods of stimulation in CA2. We also find that CA2 neurons have larger leak currents and more negative resting membrane potentials than CA1 neurons, and consequently, more current is required for action potential generation in CA2 neurons. These data suggest that the molecular "conspiracy against plasticity" in CA2 makes it functionally distinct from the other hippocampal CA regions. This work provides critical insight into hippocampal function and may lead to an understanding of the resistance of CA2 to damage from disease, trauma, and hypoxia. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Zhao, Meilan AU - Choi, Yun-Sik AU - Obrietan, Karl AU - Dudek, Serena M AD - National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/10/31/ PY - 2007 DA - 2007 Oct 31 SP - 12025 EP - 12032 VL - 27 IS - 44 KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Animals KW - Long-Term Potentiation -- radiation effects KW - Electric Stimulation -- methods KW - Status Epilepticus -- physiopathology KW - Disease Models, Animal KW - Mice KW - Dose-Response Relationship, Radiation KW - Rats KW - Animals, Newborn KW - Status Epilepticus -- chemically induced KW - Rats, Sprague-Dawley KW - Excitatory Postsynaptic Potentials -- drug effects KW - Long-Term Potentiation -- physiology KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Mice, Inbred C57BL KW - Excitatory Postsynaptic Potentials -- physiology KW - Male KW - Neuronal Plasticity -- radiation effects KW - Synaptic Transmission -- radiation effects KW - Synaptic Transmission -- drug effects KW - Hippocampus -- cytology KW - Neurons -- physiology KW - Neuronal Plasticity -- physiology KW - Synaptic Transmission -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68472250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Synaptic+plasticity+%28and+the+lack+thereof%29+in+hippocampal+CA2+neurons.&rft.au=Zhao%2C+Meilan%3BChoi%2C+Yun-Sik%3BObrietan%2C+Karl%3BDudek%2C+Serena+M&rft.aulast=Zhao&rft.aufirst=Meilan&rft.date=2007-10-31&rft.volume=27&rft.issue=44&rft.spage=12025&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [Drug dependence syndrome as a side effect of medical drug use]. AN - 69055079; 18074563 JF - Nihon rinsho. Japanese journal of clinical medicine AU - Ozaki, Shigeru AD - Department of Drug Dependence Research, National Institute of Mental Health, National Center of Neurology and Psychiatry. Y1 - 2007/10/28/ PY - 2007 DA - 2007 Oct 28 SP - 357 EP - 361 VL - 65 Suppl 8 SN - 0047-1852, 0047-1852 KW - Central Nervous System Agents KW - 0 KW - Naloxone KW - 36B82AMQ7N KW - Flumazenil KW - 40P7XK9392 KW - Clonidine KW - MN3L5RMN02 KW - Index Medicus KW - Psychotherapy, Group KW - Substance Withdrawal Syndrome -- etiology KW - Humans KW - Flumazenil -- therapeutic use KW - Naloxone -- therapeutic use KW - Clonidine -- therapeutic use KW - Substance Withdrawal Syndrome -- therapy KW - Time Factors KW - Self-Help Groups KW - Substance-Related Disorders -- therapy KW - Substance-Related Disorders -- diagnosis KW - Central Nervous System Agents -- adverse effects KW - Substance-Related Disorders -- etiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69055079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nihon+rinsho.+Japanese+journal+of+clinical+medicine&rft.atitle=%5BDrug+dependence+syndrome+as+a+side+effect+of+medical+drug+use%5D.&rft.au=Ozaki%2C+Shigeru&rft.aulast=Ozaki&rft.aufirst=Shigeru&rft.date=2007-10-28&rft.volume=65+Suppl+8&rft.issue=&rft.spage=357&rft.isbn=&rft.btitle=&rft.title=Nihon+rinsho.+Japanese+journal+of+clinical+medicine&rft.issn=00471852&rft_id=info:doi/ LA - Japanese DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-27 N1 - Date created - 2007-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The nitric oxide prodrug, V-PYRRO/NO, mitigates arsenic-induced liver cell toxicity and apoptosis. AN - 68308028; 17658681 AB - Arsenite is an important cancer chemotherapeutic. The liver is a major target tissue of arsenic toxicity and hepatotoxicity may limit its chemotherapeutic efficacy. O(2)-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) is a liver-selective nitric oxide (NO)-producing prodrug metabolized by hepatic P450 enzymes to release NO locally. V-PYRRO/NO protects against various organic or inorganic hepatotoxicants but any role in arsenic hepatotoxicity is undefined. Thus, we studied the effects of V-PYRRO/NO (0-1000muM) pretreatment on inorganic arsenic-induced toxicity in cultured rat liver (TRL 1215) cells. These cells metabolized the prodrug to release NO, producing extracellular nitrite levels to 41.7-fold above control levels (7.50+/-0.38 microM) after 24h V-PYRRO/NO (1000 microM) exposure. The effect of pretreatment with V-PYRRO/NO (24h) on the cytolethality of arsenic (as NaAsO(2)) exposure (24h) was assessed. Arsenic was markedly less toxic in V-PYRRO/NO pretreated cells (LC(50)=30.3 microM) compared to control (LC(50)=20.1 microM) and the increases in LC(50) showed a direct relationship to the level of NO produced (measured as nitrite). Consistent with the cytolethality data, V-PYRRO/NO pretreatment markedly reduced arsenic-induced apoptosis as assessed by DNA fragmentation. Activation of the c-Jun N-terminal kinase (JNK) pathway can be critical to apoptosis and pretreatment with V-PYRRO/NO suppressed arsenic-induced JNK activation. V-PYRRO/NO pretreatment modestly increased metallothionein (MT), a metal-binding protein, but greatly enhanced arsenic induction of MT. Thus, V-PYRRO/NO pretreatment directly mitigates arsenic toxicity in cultured liver cells, reducing cytolethality, apoptosis and related JNK pathway activation, apparently through generation of NO. The role of NO in reducing the hepatotoxicity of arsenical chemotherapeutics in vivo deserves additional study. JF - Cancer letters AU - Qu, Wei AU - Liu, Jie AU - Fuquay, Richard AU - Saavedra, Joseph E AU - Keefer, Larry K AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/10/28/ PY - 2007 DA - 2007 Oct 28 SP - 238 EP - 245 VL - 256 IS - 2 SN - 0304-3835, 0304-3835 KW - Antineoplastic Agents KW - 0 KW - Arsenites KW - Nitric Oxide Donors KW - Nitrites KW - O(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate KW - Protective Agents KW - Pyrrolidines KW - Sodium Compounds KW - Nitric Oxide KW - 31C4KY9ESH KW - sodium arsenite KW - 48OVY2OC72 KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Metallothionein KW - 9038-94-2 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Metallothionein -- biosynthesis KW - Nitrites -- metabolism KW - Dose-Response Relationship, Drug KW - Cytoprotection KW - Cytochrome P-450 Enzyme System -- metabolism KW - Rats KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- drug effects KW - Phosphorylation KW - Cell Survival -- drug effects KW - Epithelial Cells -- pathology KW - Up-Regulation KW - Inhibitory Concentration 50 KW - Cell Line KW - JNK Mitogen-Activated Protein Kinases -- metabolism KW - Liver -- enzymology KW - Liver -- pathology KW - Arsenites -- toxicity KW - Liver -- metabolism KW - Nitric Oxide -- metabolism KW - Protective Agents -- pharmacology KW - Pyrrolidines -- metabolism KW - Nitric Oxide Donors -- metabolism KW - Nitric Oxide Donors -- pharmacology KW - Liver -- drug effects KW - Apoptosis -- drug effects KW - Sodium Compounds -- toxicity KW - Antineoplastic Agents -- toxicity KW - Pyrrolidines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68308028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=The+nitric+oxide+prodrug%2C+V-PYRRO%2FNO%2C+mitigates+arsenic-induced+liver+cell+toxicity+and+apoptosis.&rft.au=Qu%2C+Wei%3BLiu%2C+Jie%3BFuquay%2C+Richard%3BSaavedra%2C+Joseph+E%3BKeefer%2C+Larry+K%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2007-10-28&rft.volume=256&rft.issue=2&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-20 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1998 Sep;275(3 Pt 1):L551-8 [9728050] J Med Chem. 1997 Jun 20;40(13):1947-54 [9207935] J Biol Chem. 1998 Dec 4;273(49):33027-34 [9830056] J Immunol. 1999 Mar 15;162(6):3395-401 [10092794] Annu Rev Pharmacol Toxicol. 1999;39:267-94 [10331085] Cancer Res. 1999 Jul 1;59(13):3053-8 [10397243] Toxicology. 2005 Mar 15;208(2):289-97 [15691592] Nitric Oxide. 2005 Mar;12(2):114-20 [15740985] J Clin Oncol. 2005 Apr 1;23(10):2396-410 [15800332] Leukemia. 2006 May;20(5):881-3 [16525498] J Am Chem Soc. 2006 Sep 27;128(38):12473-83 [16984198] Environ Health Perspect. 2007 Jul;115(7):1101-6 [17637929] Toxicol Sci. 2000 Jun;55(2):460-7 [10828279] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14382-7 [11121042] Transplantation. 2001 Jan 27;71(2):193-8 [11213058] Biol Trace Elem Res. 2000 Winter;78(1-3):241-54 [11314982] Toxicol Lett. 2001 Feb 28;119(2):103-8 [11311571] J Pharmacol Exp Ther. 2002 Jan;300(1):18-25 [11752092] Carcinogenesis. 2002 Jan;23(1):151-9 [11756236] Am J Physiol Lung Cell Mol Physiol. 2002 Feb;282(2):L185-92 [11792622] Annu Rev Pharmacol Toxicol. 2003;43:585-607 [12415121] Hepatology. 2003 Feb;37(2):324-33 [12540782] Chem Res Toxicol. 2003 Jul;16(7):873-80 [12870890] J Pharmacol Exp Ther. 2004 Jul;310(1):18-24 [15010501] J Hepatol. 2004 Jul;41(1):55-9 [15246208] Toxicol Appl Pharmacol. 1982 Oct;66(1):134-42 [7157381] Fundam Appl Toxicol. 1993 Feb;20(2):184-9 [8449390] Science. 1995 Nov 24;270(5240):1326-31 [7481820] J Biol Chem. 1996 Jun 28;271(26):15703-7 [8663189] Blood. 1996 Aug 1;88(3):1052-61 [8704214] J Biol Chem. 1996 Aug 16;271(33):19705-9 [8702674] Blood. 1997 May 1;89(9):3354-60 [9129042] Biochem Mol Biol Int. 1998 Sep;45(6):1121-7 [9762410] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. AN - 68412206; 17720976 AB - Cripto-1 (CR-1) is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that has been shown to play an important role in embryogenesis and cellular transformation. CR-1 is reported to function as a membrane-bound co-receptor and as a soluble ligand. Although a number of studies implicate the role of CR-1 as a soluble ligand in tumor progression, it is unclear how transition from the membrane-bound to the soluble form is physiologically regulated and whether differences in biological activity exist between these forms. Here, we demonstrate that CR-1 protein is secreted from tumor cells into the conditioned medium after treatment with serum, epidermal growth factor, or lysophosphatidic acid, and this soluble form of CR-1 exhibits the ability to promote endothelial cell migration as a paracrine chemoattractant. On the other hand, membrane-bound CR-1 can stimulate endothelial cell sprouting through direct cell-cell interaction. Shedding of CR-1 occurs at the GPI-anchorage site by the activity of GPI-phospholipase D (GPI-PLD), because CR-1 shedding was suppressed by siRNA knockdown of GPI-PLD and enhanced by overexpression of GPI-PLD. These findings describe a novel molecular mechanism of CR-1 shedding, which may contribute to endothelial cell migration and possibly tumor angiogenesis. JF - The Journal of biological chemistry AU - Watanabe, Kazuhide AU - Bianco, Caterina AU - Strizzi, Luigi AU - Hamada, Shin AU - Mancino, Mario AU - Bailly, Veronique AU - Mo, Wenjun AU - Wen, Dingyi AU - Miatkowski, Konrad AU - Gonzales, Monica AU - Sanicola, Michele AU - Seno, Masaharu AU - Salomon, David S AD - Tumor Growth Factor Section, Mammary Biology & Tumorigenesis Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 SP - 31643 EP - 31655 VL - 282 IS - 43 SN - 0021-9258, 0021-9258 KW - Fluorescent Dyes KW - 0 KW - GPI-Linked Proteins KW - Glycosylphosphatidylinositols KW - Growth Substances KW - Indoles KW - Intercellular Signaling Peptides and Proteins KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - RNA, Small Interfering KW - Rhodamines KW - TDGF1 protein, human KW - Phalloidine KW - 17466-45-4 KW - DAPI KW - 47165-04-8 KW - Epidermal Growth Factor KW - 62229-50-9 KW - Phospholipase D KW - EC 3.1.4.4 KW - Index Medicus KW - Cell Movement KW - Mass Spectrometry KW - Animals KW - Coculture Techniques KW - COS Cells KW - Endothelium, Vascular -- cytology KW - Humans KW - Umbilical Veins -- cytology KW - Cell Line, Tumor KW - RNA, Small Interfering -- metabolism KW - Adenocarcinoma -- pathology KW - Cercopithecus aethiops KW - Kidney -- cytology KW - Dogs KW - Colonic Neoplasms -- pathology KW - Cell Line KW - Phospholipase D -- metabolism KW - Phospholipase D -- genetics KW - Endothelial Cells -- physiology KW - Glycosylphosphatidylinositols -- genetics KW - Glycosylphosphatidylinositols -- metabolism KW - Neoplasm Proteins -- metabolism KW - Growth Substances -- physiology KW - Epidermal Growth Factor -- metabolism KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68412206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Growth+factor+induction+of+Cripto-1+shedding+by+glycosylphosphatidylinositol-phospholipase+D+and+enhancement+of+endothelial+cell+migration.&rft.au=Watanabe%2C+Kazuhide%3BBianco%2C+Caterina%3BStrizzi%2C+Luigi%3BHamada%2C+Shin%3BMancino%2C+Mario%3BBailly%2C+Veronique%3BMo%2C+Wenjun%3BWen%2C+Dingyi%3BMiatkowski%2C+Konrad%3BGonzales%2C+Monica%3BSanicola%2C+Michele%3BSeno%2C+Masaharu%3BSalomon%2C+David+S&rft.aulast=Watanabe&rft.aufirst=Kazuhide&rft.date=2007-10-26&rft.volume=282&rft.issue=43&rft.spage=31643&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suppression of gross chromosomal rearrangements by a new alternative replication factor C complex. AN - 68258567; 17689491 AB - Defects in DNA replication fidelity lead to genomic instability. Gross chromosomal rearrangement (GCR), a type of genomic instability, is highly enhanced by various initial mutations affecting DNA replication. Frequent observations of GCRs in many cancers strongly argue the importance of maintaining high fidelity of DNA replication to suppress carcinogenesis. Recent genome wide screens in Saccharomyces cerevisiae identified a new GCR suppressor gene, ELG1, enhanced level of genome instability gene 1. Its physical interaction with proliferating cell nuclear antigen (PCNA) and complex formation with Rfc2-5p proteins suggest that Elg1 functions to load/unload PCNA onto DNA during a certain DNA metabolism. High level of DNA damage accumulation and enhanced phenotypes with mutations in genes involved in cell cycle checkpoints, homologous recombination (HR), or chromatin assembly in the elg1 strain suggest that Elg1p-Rfc2-5p functions in a fundamental DNA metabolism to suppress genomic instability. JF - Biochemical and biophysical research communications AU - Banerjee, Soma AU - Sikdar, Nilabja AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Room 4A22, Bethesda, MD 20892, USA. Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 SP - 546 EP - 549 VL - 362 IS - 3 SN - 0006-291X, 0006-291X KW - Carrier Proteins KW - 0 KW - Elg1 protein, S cerevisiae KW - Proliferating Cell Nuclear Antigen KW - Replication Protein C KW - Saccharomyces cerevisiae Proteins KW - Index Medicus KW - Animals KW - Carrier Proteins -- chemistry KW - Humans KW - Mice KW - Rats KW - Saccharomyces cerevisiae -- genetics KW - Saccharomyces cerevisiae -- metabolism KW - Fishes KW - Models, Genetic KW - Proliferating Cell Nuclear Antigen -- chemistry KW - Recombination, Genetic KW - Chromosomes -- ultrastructure KW - DNA Replication KW - Replication Protein C -- chemistry KW - Replication Protein C -- metabolism KW - Chromosome Aberrations UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68258567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Suppression+of+gross+chromosomal+rearrangements+by+a+new+alternative+replication+factor+C+complex.&rft.au=Banerjee%2C+Soma%3BSikdar%2C+Nilabja%3BMyung%2C+Kyungjae&rft.aulast=Banerjee&rft.aufirst=Soma&rft.date=2007-10-26&rft.volume=362&rft.issue=3&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):776-81 [12552134] Science. 2002 Jul 26;297(5581):552-7 [12142524] Genes Chromosomes Cancer. 2003 Jun;37(2):111-20 [12696059] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6640-5 [12750463] EMBO J. 2003 Aug 15;22(16):4304-13 [12912927] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9906-11 [12909721] Curr Biol. 2003 Sep 16;13(18):1583-95 [13678589] Mutat Res. 2003 Nov 27;532(1-2):117-35 [14643433] Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9039-44 [15184655] Bioessays. 1994 Apr;16(4):253-8 [8031302] Curr Opin Genet Dev. 1994 Apr;4(2):229-35 [8032200] Genes Dev. 1996 Jun 15;10(12):1433-42 [8666228] Annu Rev Biochem. 1998;67:721-51 [9759502] Eukaryot Cell. 2004 Dec;3(6):1557-66 [15590829] DNA Repair (Amst). 2005 Apr 4;4(4):409-17 [15725622] Mol Cell Biol. 2005 Jul;25(13):5445-55 [15964801] Methods Enzymol. 2006;409:1-11 [16793392] Methods. 2007 Feb;41(2):168-76 [17189859] Nucleic Acids Res. 2007;35(2):353-62 [17170004] Cell. 2007 May 18;129(4):665-79 [17512402] Nat Genet. 2001 Mar;27(3):247-54 [11242102] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11236-41 [11572977] Mol Cell Biol. 2002 Jan;22(2):614-25 [11756556] Mol Cell. 2003 Feb;11(2):341-51 [12620223] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Multiple Signaling Pathways are Involved in IL-21-Mediated Proliferation. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40717774; 4756273 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Zeng, Rong AU - Spolski, Rosanne AU - Casas, Esther AU - Zhu, Wei AU - Levy, David E AU - Leonard, Warren J Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40717774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Multiple+Signaling+Pathways+are+Involved+in+IL-21-Mediated+Proliferation.&rft.au=Zeng%2C+Rong%3BSpolski%2C+Rosanne%3BCasas%2C+Esther%3BZhu%2C+Wei%3BLevy%2C+David+E%3BLeonard%2C+Warren+J&rft.aulast=Zeng&rft.aufirst=Rong&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of MPAK and NF-kB Signaling to TLR Mediated MCP-1 Secretion. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40716558; 4756261 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Vivekanandhan, Aravindhan AU - Klinman, Dennis M Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Secretion KW - Signal transduction KW - Monocyte chemoattractant protein 1 KW - NF-B protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Contribution+of+MPAK+and+NF-kB+Signaling+to+TLR+Mediated+MCP-1+Secretion.&rft.au=Vivekanandhan%2C+Aravindhan%3BKlinman%2C+Dennis+M&rft.aulast=Vivekanandhan&rft.aufirst=Aravindhan&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparatively Diminished Cytokine and Superoxide Induction by the Emerging Pathogen Granulibacter Bethesdensis: Implications for Pathogenesis. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40716167; 4756271 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Zarember, Kol A AU - DeLeo, Frank R AU - Whitney, Addie R AU - Shoffner, Adam R AU - Dorward, David W AU - Gallin, John I AU - Holland, Steven M AU - Greenberg, David E Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Pathogens KW - Cytokines KW - Superoxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Comparatively+Diminished+Cytokine+and+Superoxide+Induction+by+the+Emerging+Pathogen+Granulibacter+Bethesdensis%3A+Implications+for+Pathogenesis.&rft.au=Zarember%2C+Kol+A%3BDeLeo%2C+Frank+R%3BWhitney%2C+Addie+R%3BShoffner%2C+Adam+R%3BDorward%2C+David+W%3BGallin%2C+John+I%3BHolland%2C+Steven+M%3BGreenberg%2C+David+E&rft.aulast=Zarember&rft.aufirst=Kol&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of IRF-9 is Important in the Antiproliferative Response to IFN-a in Jak-STAT Signaling Pathway of OVCAR3 Cells. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40716084; 4756254 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Tsuno, Takaya AU - Mejido, Josef AU - Schmeisser, Hana AU - Fey, Samuel AU - Morrow, Angel AU - Nie, Huiqin AU - Zhao, Tongmao AU - Bekisz, Joseph AU - Goldman, Neil AU - Zoon, Kathryn Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Signal transduction KW - A-Interferon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Synthesis+of+IRF-9+is+Important+in+the+Antiproliferative+Response+to+IFN-a+in+Jak-STAT+Signaling+Pathway+of+OVCAR3+Cells.&rft.au=Tsuno%2C+Takaya%3BMejido%2C+Josef%3BSchmeisser%2C+Hana%3BFey%2C+Samuel%3BMorrow%2C+Angel%3BNie%2C+Huiqin%3BZhao%2C+Tongmao%3BBekisz%2C+Joseph%3BGoldman%2C+Neil%3BZoon%2C+Kathryn&rft.aulast=Tsuno&rft.aufirst=Takaya&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prostaglandin E@@d2@ is a Major Inhibitor of Dendritic Cell Maturation and Function in Ixodes scapularis Saliva. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40716064; 4756232 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Sa-Nunes, Anderson AU - Bafica, Andre AU - Lucas, David A AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Andersen, John F AU - Mather, Thomas N AU - Ribeiro, Jose M.C. AU - Francischetti, Ivo M.B. Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Dendritic cells KW - Saliva KW - Prostaglandin E2 KW - Sexual maturity KW - Inhibitors KW - Ixodes scapularis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40716064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Prostaglandin+E%40%40d2%40+is+a+Major+Inhibitor+of+Dendritic+Cell+Maturation+and+Function+in+Ixodes+scapularis+Saliva.&rft.au=Sa-Nunes%2C+Anderson%3BBafica%2C+Andre%3BLucas%2C+David+A%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BAndersen%2C+John+F%3BMather%2C+Thomas+N%3BRibeiro%2C+Jose+M.C.%3BFrancischetti%2C+Ivo+M.B.&rft.aulast=Sa-Nunes&rft.aufirst=Anderson&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Activation of Gene Transcription Following TLR3 and TLR9 Stimulation. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715788; 4756344 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Petrenko, Lev AU - Klaschik, Sven AU - Sato, Takashi AU - Shirota, Hidekazu AU - Klinman, Dennis M Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Toll-like receptors KW - TLR3 protein KW - Transcription activation KW - Transcription KW - TLR9 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Synergistic+Activation+of+Gene+Transcription+Following+TLR3+and+TLR9+Stimulation.&rft.au=Petrenko%2C+Lev%3BKlaschik%2C+Sven%3BSato%2C+Takashi%3BShirota%2C+Hidekazu%3BKlinman%2C+Dennis+M&rft.aulast=Petrenko&rft.aufirst=Lev&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CREB/ATF-Dependent T-Cell Receptor-Induced FoxP3 Gene Expression: A Role for DNA Methylation. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715598; 4756172 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Kim, Hyoung-Pyo AU - Leonard, Warren J Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Cyclic AMP response element-binding protein KW - Lymphocytes T KW - DNA methylation KW - Foxp3 protein KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=CREB%2FATF-Dependent+T-Cell+Receptor-Induced+FoxP3+Gene+Expression%3A+A+Role+for+DNA+Methylation.&rft.au=Kim%2C+Hyoung-Pyo%3BLeonard%2C+Warren+J&rft.aulast=Kim&rft.aufirst=Hyoung-Pyo&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Il-7 Receptor and the Role of STAT5. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715568; 4756281 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Cavinato, Tiziana AU - Jiang, Qiong AU - Li, Wenqing Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Stat5 protein KW - Interleukin 7 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Il-7+Receptor+and+the+Role+of+STAT5.&rft.au=Cavinato%2C+Tiziana%3BJiang%2C+Qiong%3BLi%2C+Wenqing&rft.aulast=Cavinato&rft.aufirst=Tiziana&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Challening Evolution: Eliminating the IFN-gamma 3 are Effects T Cell Homeostasis. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715545; 4756153 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Hodge, Deborah L AU - Berthet, Cyril AU - Subleski, Jeff AU - Pascal, Veronique AU - Bere, William AU - Chen, Xin AU - Buschman, Matthew AU - Wolfe, Thomas AU - Young, Howard A Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - G-Interferon KW - Lymphocytes T KW - Homeostasis KW - Evolution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Challening+Evolution%3A+Eliminating+the+IFN-gamma+3+are+Effects+T+Cell+Homeostasis.&rft.au=Hodge%2C+Deborah+L%3BBerthet%2C+Cyril%3BSubleski%2C+Jeff%3BPascal%2C+Veronique%3BBere%2C+William%3BChen%2C+Xin%3BBuschman%2C+Matthew%3BWolfe%2C+Thomas%3BYoung%2C+Howard+A&rft.aulast=Hodge&rft.aufirst=Deborah&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Drug CP690550 Inhibits the JAK3/STAT5 Pathway In Vitro and In Vivo. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715314; 4756166 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Ju, Wei AU - Zhang, Meili AU - Chen, Jing AU - Thomas, Craig J AU - Waldmann, Thomas A Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Drugs KW - Jak3 kinase KW - Stat5 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=The+Drug+CP690550+Inhibits+the+JAK3%2FSTAT5+Pathway+In+Vitro+and+In+Vivo.&rft.au=Ju%2C+Wei%3BZhang%2C+Meili%3BChen%2C+Jing%3BThomas%2C+Craig+J%3BWaldmann%2C+Thomas+A&rft.aulast=Ju&rft.aufirst=Wei&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NKT Cells Constitutively Express IL-23 Receptor and can Rapidly Produce IL-17 Independently of IL-6 Following IL-23 or T Cell Receptor Ligation. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40715238; 4756148 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Hansen, Anna M AU - Rachitskya, Aleksandra AU - Horai, Raiko AU - Caspi, Rachel R Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Interleukin 23 KW - T-cell receptor KW - Interleukin 17 KW - Lymphocytes T KW - Interleukin 6 KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40715238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=NKT+Cells+Constitutively+Express+IL-23+Receptor+and+can+Rapidly+Produce+IL-17+Independently+of+IL-6+Following+IL-23+or+T+Cell+Receptor+Ligation.&rft.au=Hansen%2C+Anna+M%3BRachitskya%2C+Aleksandra%3BHorai%2C+Raiko%3BCaspi%2C+Rachel+R&rft.aulast=Hansen&rft.aufirst=Anna&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rewriting the Paradigm for IL4/STAT6 and Th2 Differentiation. New Rules for In Vivo Commitment. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40714218; 4756258 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - van Panhuys, Nicholas AU - Scarlet, Debbie AU - Camberis, Mali AU - Roberts, Joanna AU - Prout, Melanie AU - Tang, Schiau-Choot AU - Li, Jane Hu AU - Min, Booki AU - Paul, William AU - Le Gros, Graham Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Differentiation KW - Lymphocytes T KW - Stat6 protein KW - Helper cells KW - Interleukin 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Rewriting+the+Paradigm+for+IL4%2FSTAT6+and+Th2+Differentiation.+New+Rules+for+In+Vivo+Commitment.&rft.au=van+Panhuys%2C+Nicholas%3BScarlet%2C+Debbie%3BCamberis%2C+Mali%3BRoberts%2C+Joanna%3BProut%2C+Melanie%3BTang%2C+Schiau-Choot%3BLi%2C+Jane+Hu%3BMin%2C+Booki%3BPaul%2C+William%3BLe+Gros%2C+Graham&rft.aulast=van+Panhuys&rft.aufirst=Nicholas&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coreceptor Tuning: IL-7 Signals Transcriptionally Tailor CD8 Coreceptor Expression in CD8 T Cells to the Self-Specificity of their TCR. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40714105; 4756217 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Park, Jung-Hyun AU - Adoro, Stanley AU - Lucas, Philip J AU - Sarafova, Sophia D AU - Alag, Amala AU - Doan, Loretta L AU - Erman, Batu AU - Liu, Xiaolong AU - Ellmeier, Wilfried AU - Bosselut, Remy AU - Feigenbaum, Lionel AU - Singer, Alfred Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - CD8 antigen KW - T-cell receptor KW - Transcription KW - Lymphocytes T KW - Interleukin 7 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40714105?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Coreceptor+Tuning%3A+IL-7+Signals+Transcriptionally+Tailor+CD8+Coreceptor+Expression+in+CD8+T+Cells+to+the+Self-Specificity+of+their+TCR.&rft.au=Park%2C+Jung-Hyun%3BAdoro%2C+Stanley%3BLucas%2C+Philip+J%3BSarafova%2C+Sophia+D%3BAlag%2C+Amala%3BDoan%2C+Loretta+L%3BErman%2C+Batu%3BLiu%2C+Xiaolong%3BEllmeier%2C+Wilfried%3BBosselut%2C+Remy%3BFeigenbaum%2C+Lionel%3BSinger%2C+Alfred&rft.aulast=Park&rft.aufirst=Jung-Hyun&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role for IL-23 but Not for the TH17 Effector Response in Pathogenesis of Experimental Ocular Autoimmunity. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40713625; 4756192 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Luger, Dror AU - Silver, Phyllis B AU - Tang, Jun AU - Cua, Daniel AU - Chen, Zoe AU - Iwakura, Yoichiro AU - Bowman, Edward P AU - Sgambellone, Nicole AU - Chan, Chi-Chao AU - Caspi, Rachel R Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Autoimmunity KW - Interleukin 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40713625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Essential+Role+for+IL-23+but+Not+for+the+TH17+Effector+Response+in+Pathogenesis+of+Experimental+Ocular+Autoimmunity.&rft.au=Luger%2C+Dror%3BSilver%2C+Phyllis+B%3BTang%2C+Jun%3BCua%2C+Daniel%3BChen%2C+Zoe%3BIwakura%2C+Yoichiro%3BBowman%2C+Edward+P%3BSgambellone%2C+Nicole%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Luger&rft.aufirst=Dror&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biological Regulators of CD4+CD25+FoxP3+Regulatory T-Cells. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40712489; 4756155 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Howard, O. M. Zack AU - Oppenheim, Joost J AU - Chen, Xin Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40712489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Biological+Regulators+of+CD4%2BCD25%2BFoxP3%2BRegulatory+T-Cells.&rft.au=Howard%2C+O.+M.+Zack%3BOppenheim%2C+Joost+J%3BChen%2C+Xin&rft.aulast=Howard&rft.aufirst=O.+M.&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IFN-g Message is Maintained Long Term in Influenza-Specific CD8+ T Cells and Upregulated after Secondary Challenge in an Antigen-Dependent Manner. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40711199; 4756342 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Mayer, Katrin D AU - Woodland, David L AU - Mohrs, Markus Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - G-Interferon KW - CD8 antigen KW - Lymphocytes T KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40711199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=IFN-g+Message+is+Maintained+Long+Term+in+Influenza-Specific+CD8%2B+T+Cells+and+Upregulated+after+Secondary+Challenge+in+an+Antigen-Dependent+Manner.&rft.au=Mayer%2C+Katrin+D%3BWoodland%2C+David+L%3BMohrs%2C+Markus&rft.aulast=Mayer&rft.aufirst=Katrin&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of Skin Wound Healing by Chemokine Receptor CX3CR1 in Mice. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40710242; 4756160 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Ishida, Yuko AU - Gao, Ji-Liang AU - Murphy, Philip M Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Skin KW - Mice KW - CX3CR1 protein KW - Chemokine receptors KW - Wound healing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40710242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Regulation+of+Skin+Wound+Healing+by+Chemokine+Receptor+CX3CR1+in+Mice.&rft.au=Ishida%2C+Yuko%3BGao%2C+Ji-Liang%3BMurphy%2C+Philip+M&rft.aulast=Ishida&rft.aufirst=Yuko&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of the IL-9 Gene by HTLV-I Tax Stimulates the Spontaneous Proliferation of Primary ATL Cells by a Paracrine Mechanism. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40699867; 4756117 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Chen, Jing AU - Petrus, Mike AU - Bryant, Bonita AU - Nguyen, Vinh Phuc AU - Stamer, Mindy AU - Goldman, Carolyn AU - Bamford, Richard AU - Morris, John C AU - Janik, John E AU - Waldmann, Thomas A Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Taxation KW - Cell proliferation KW - Paracrine signalling KW - Interleukin 9 KW - Human T-lymphotropic virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Induction+of+the+IL-9+Gene+by+HTLV-I+Tax+Stimulates+the+Spontaneous+Proliferation+of+Primary+ATL+Cells+by+a+Paracrine+Mechanism.&rft.au=Chen%2C+Jing%3BPetrus%2C+Mike%3BBryant%2C+Bonita%3BNguyen%2C+Vinh+Phuc%3BStamer%2C+Mindy%3BGoldman%2C+Carolyn%3BBamford%2C+Richard%3BMorris%2C+John+C%3BJanik%2C+John+E%3BWaldmann%2C+Thomas+A&rft.aulast=Chen&rft.aufirst=Jing&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualization and Identification of IL-7 Producing Cells. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40699711; 4756132 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Durum, Scott K AU - Warming, Soren AU - Lawrence, Scott M AU - Ishii, Masaru AU - Abshari, Mehrnoosh AU - Feigenbaum, Lionel AU - Washington, A Valance AU - Warner, Andrew C AU - Sims, David J AU - Li, Wen Qing AU - Hixon, Julie A AU - Gray, Daniel H.D. AU - Rich, Benjamin E AU - Morrow, Matthew AU - Anver, Miriam R AU - Cherry, James AU - Naf, Dieter AU - Sternberg, Lawrence R AU - McVicar, Daniel W AU - Farr, Andrew G AU - Germain, Ronald N AU - Rogers, Keith AU - Copeland, Neal G AU - Mazzucchelli, Renata Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Interleukin 7 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=Visualization+and+Identification+of+IL-7+Producing+Cells.&rft.au=Durum%2C+Scott+K%3BWarming%2C+Soren%3BLawrence%2C+Scott+M%3BIshii%2C+Masaru%3BAbshari%2C+Mehrnoosh%3BFeigenbaum%2C+Lionel%3BWashington%2C+A+Valance%3BWarner%2C+Andrew+C%3BSims%2C+David+J%3BLi%2C+Wen+Qing%3BHixon%2C+Julie+A%3BGray%2C+Daniel+H.D.%3BRich%2C+Benjamin+E%3BMorrow%2C+Matthew%3BAnver%2C+Miriam+R%3BCherry%2C+James%3BNaf%2C+Dieter%3BSternberg%2C+Lawrence+R%3BMcVicar%2C+Daniel+W%3BFarr%2C+Andrew+G%3BGermain%2C+Ronald+N%3BRogers%2C+Keith%3BCopeland%2C+Neal+G%3BMazzucchelli%2C+Renata&rft.aulast=Durum&rft.aufirst=Scott&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - HIV Infection Leads to Increased Immune Activation by 2 Distinct Pathways that Differentially Affect CD4 and CD8 T Cells. T2 - Fifteenth Annual Meeting of the International Cytokine Society AN - 40697725; 4756115 JF - Fifteenth Annual Meeting of the International Cytokine Society AU - Catalfamo, Marta AU - Di Mascio, Michele AU - Tagaya, Yutaka AU - Sriniasula, Sharat AU - V, Thaker AU - Adelsberger, Joseph AU - Rupert, Adam AU - Baseler, Michael AU - Roby, Gregg AU - Rehm, Catherine AU - Lane, Clifford Y1 - 2007/10/26/ PY - 2007 DA - 2007 Oct 26 KW - Human immunodeficiency virus KW - Infection KW - CD8 antigen KW - Lymphocytes T KW - CD4 antigen KW - Cell activation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40697725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.atitle=HIV+Infection+Leads+to+Increased+Immune+Activation+by+2+Distinct+Pathways+that+Differentially+Affect+CD4+and+CD8+T+Cells.&rft.au=Catalfamo%2C+Marta%3BDi+Mascio%2C+Michele%3BTagaya%2C+Yutaka%3BSriniasula%2C+Sharat%3BV%2C+Thaker%3BAdelsberger%2C+Joseph%3BRupert%2C+Adam%3BBaseler%2C+Michael%3BRoby%2C+Gregg%3BRehm%2C+Catherine%3BLane%2C+Clifford&rft.aulast=Catalfamo&rft.aufirst=Marta&rft.date=2007-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifteenth+Annual+Meeting+of+the+International+Cytokine+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.cytokines2007.org/abstracts2.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines. AN - 68411007; 17918856 AB - Nitric oxide prodrugs derived from hindered secondary amines were prepared. The decomposition patterns of these prodrugs indicate that alpha-methyl groups around the nitrogen bearing the diazeniumdiolate group prolong their half-life in aqueous buffer. JF - Organic letters AU - Chakrapani, Harinath AU - Showalter, Brett M AU - Citro, Michael L AU - Keefer, Larry K AU - Saavedra, Joseph E AD - Chemistry Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Y1 - 2007/10/25/ PY - 2007 DA - 2007 Oct 25 SP - 4551 EP - 4554 VL - 9 IS - 22 SN - 1523-7060, 1523-7060 KW - Amines KW - 0 KW - Azo Compounds KW - Prodrugs KW - diazeniumdiolate KW - Nitric Oxide KW - 31C4KY9ESH KW - Index Medicus KW - Molecular Structure KW - Prodrugs -- chemistry KW - Azo Compounds -- chemistry KW - Amines -- chemistry KW - Nitric Oxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68411007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Organic+letters&rft.atitle=Nitric+oxide+prodrugs%3A+diazeniumdiolate+anions+of+hindered+secondary+amines.&rft.au=Chakrapani%2C+Harinath%3BShowalter%2C+Brett+M%3BCitro%2C+Michael+L%3BKeefer%2C+Larry+K%3BSaavedra%2C+Joseph+E&rft.aulast=Chakrapani&rft.aufirst=Harinath&rft.date=2007-10-25&rft.volume=9&rft.issue=22&rft.spage=4551&rft.isbn=&rft.btitle=&rft.title=Organic+letters&rft.issn=15237060&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-07 N1 - Date created - 2007-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors. AN - 68431860; 17940013 AB - Recombinant immunotoxins are chimeric proteins composed of the Fv portion of a tumor-specific antibody fused to a toxin. SS1P (CAT-5001) is an immunotoxin composed of an antimesothelin Fv fused to a 38-kDa portion of Pseudomonas exotoxin A. Immunotoxins have been shown to be active in lymphomas and leukemias, but are much less active against solid tumors. We recently reported that Taxol and other chemotherapeutic agents show striking synergistic antitumor activity in mice when immunotoxin SS1P, which targets the mesothelin antigen on solid tumors, is given with Taxol. Using a pair of Taxol-sensitive and Taxol-resistant KB tumors equally sensitive to immunotoxin SS1P, we examined the mechanism of synergy. We show that synergy is only observed with Taxol-sensitive tumors, ruling out an effect of Taxol on endothelial cells. We also show that the KB tumors have high levels of shed mesothelin in their extracellular space; these levels increase with tumor size and, after Taxol treatment, dramatically fall in the drug-sensitive but not the drug-resistant tumors. Because the mesothelin levels in the tumor exceed the levels of SS1P in the tumor, and because shed mesothelin is being continuously released into the circulation at a high rate, we propose that synergy is due to the Taxol-induced fall in shed antigen levels. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Zhang, Yujian AU - Xiang, Laiman AU - Hassan, Raffit AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 SP - 17099 EP - 17104 VL - 104 IS - 43 SN - 0027-8424, 0027-8424 KW - GPI-Linked Proteins KW - 0 KW - Immunotoxins KW - Membrane Glycoproteins KW - Receptors, Transferrin KW - mesothelin KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Animals KW - Humans KW - Xenograft Model Antitumor Assays KW - Mice, Nude KW - Mice KW - Cell Line, Tumor KW - Drug Synergism KW - Receptors, Transferrin -- metabolism KW - Neoplasms -- pathology KW - Membrane Glycoproteins -- blood KW - Extracellular Space -- metabolism KW - Paclitaxel -- pharmacology KW - Immunotoxins -- pharmacology KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68431860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Immunotoxin+and+Taxol+synergy+results+from+a+decrease+in+shed+mesothelin+levels+in+the+extracellular+space+of+tumors.&rft.au=Zhang%2C+Yujian%3BXiang%2C+Laiman%3BHassan%2C+Raffit%3BPastan%2C+Ira&rft.aulast=Zhang&rft.aufirst=Yujian&rft.date=2007-10-23&rft.volume=104&rft.issue=43&rft.spage=17099&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Somat Cell Mol Genet. 1985 Mar;11(2):117-26 [3856953] Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3731-41 [14506165] Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8999-9003 [7568060] Nat Med. 1996 Mar;2(3):350-3 [8612238] Cancer Res. 1999 Aug 1;59(15):3776-82 [10446995] Mol Pharmacol. 2004 Dec;66(6):1397-405 [15342794] Clin Cancer Res. 2005 Aug 15;11(16):5840-6 [16115924] J Physiol. 2005 Sep 1;567(Pt 2):557-67 [15994186] J Clin Oncol. 2005 Sep 20;23(27):6719-29 [16061911] Clin Cancer Res. 2006 Jan 15;12(2):447-53 [16428485] Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5929-34 [16585525] Nat Rev Cancer. 2006 Jul;6(7):559-65 [16794638] Clin Cancer Res. 2006 Aug 1;12(15):4695-701 [16899620] Gynecol Oncol. 2006 Sep;102(3):462-7 [16434088] Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1751 [16985043] Best Pract Res Clin Haematol. 2006;19(4):685-99 [16997177] Eur J Haematol. 2006 Nov;77(5):387-94 [16879607] Anticancer Res. 2006 Nov-Dec;26(6C):4721-8 [17214332] Clin Cancer Res. 2007 Mar 1;13(5):1571-5 [17332303] Expert Rev Mol Diagn. 2007 May;7(3):309-19 [17489737] Curr Opin Pulm Med. 2007 Jul;13(4):339-443 [17534183] Clin Cancer Res. 2007 Sep 1;13(17):5144-9 [17785569] Cancer Res. 2000 May 1;60(9):2497-503 [10811131] Cancer Treat Rev. 2000 Aug;26(4):269-86 [10913382] Clin Cancer Res. 2000 Sep;6(9):3621-8 [10999754] Int J Oncol. 2000 Oct;17(4):643-51 [10995873] J Clin Oncol. 2001 Jan 15;19(2):376-88 [11208829] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Annu Rev Biomed Eng. 1999;1:241-63 [11701489] Biol Chem. 2002 Jan;383(1):69-83 [11928824] Pharm Res. 2003 Sep;20(9):1337-50 [14567626] Front Biosci. 2004 Sep 1;9:3085-90 [15353339] Tumour Biol. 2002 May-Jun;23(3):146-53 [12218295] Mol Cancer Ther. 2001 Dec;1(2):79-84 [12467225] Am J Physiol Heart Circ Physiol. 2003 Jan;284(1):H416-24 [12388326] Annu Rev Med. 2003;54:343-69 [12525678] Cancer Res. 2003 Aug 1;63(15):4490-6 [12907622] Blood. 2003 Oct 1;102(7):2351-7 [12750161] Cancer Res. 1992 Oct 1;52(19):5144-53 [1327501] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Folate Metabolism Genes and their Associations with Oral Facial Clefts. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40707846; 4752218 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Boyles, A L AU - Wilcox, A J AU - Taylor, J A AU - Shi, M AU - Weinberg, C R AU - Meyer, K AU - Fredriksen, A AU - Ueland, P M AU - Drevon, C A AU - Solvoll, K AU - Murray, J C AU - Jugessur, A AU - Lie, R T Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Metabolism KW - Folic acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Folate+Metabolism+Genes+and+their+Associations+with+Oral+Facial+Clefts.&rft.au=Boyles%2C+A+L%3BWilcox%2C+A+J%3BTaylor%2C+J+A%3BShi%2C+M%3BWeinberg%2C+C+R%3BMeyer%2C+K%3BFredriksen%2C+A%3BUeland%2C+P+M%3BDrevon%2C+C+A%3BSolvoll%2C+K%3BMurray%2C+J+C%3BJugessur%2C+A%3BLie%2C+R+T&rft.aulast=Boyles&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Genotyping Using Next Generation Sequencing Technology. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40707112; 4752276 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Xiao, N AU - Desany, B AU - Bouffard, P AU - Burdett, L A AU - Welch, R AU - Yeager, M AU - Jarvie, T P AU - Harkins, T T AU - Qi, L. AU - Lu, J. AU - Chanock, S J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Technology KW - Genotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40707112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Human+Genotyping+Using+Next+Generation+Sequencing+Technology.&rft.au=Xiao%2C+N%3BDesany%2C+B%3BBouffard%2C+P%3BBurdett%2C+L+A%3BWelch%2C+R%3BYeager%2C+M%3BJarvie%2C+T+P%3BHarkins%2C+T+T%3BQi%2C+L.%3BLu%2C+J.%3BChanock%2C+S+J&rft.aulast=Xiao&rft.aufirst=N&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Common Variation at 8q24 and Prostate Cancer Risk. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40706416; 4752302 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Yeager-Jeffery, M AU - Welch, R AU - Hayes, R B AU - Bouffard, P AU - Xiao, N AU - Burdett, L AU - Orr, N AU - Crenshaw, A AU - Markovic, Z AU - Jacobs, K B AU - Jarvie, T P AU - Hunter, D AU - Hoover, R AU - Thomas, G AU - Harkins, T T AU - Chanock, S J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Prostate cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40706416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Common+Variation+at+8q24+and+Prostate+Cancer+Risk.&rft.au=Yeager-Jeffery%2C+M%3BWelch%2C+R%3BHayes%2C+R+B%3BBouffard%2C+P%3BXiao%2C+N%3BBurdett%2C+L%3BOrr%2C+N%3BCrenshaw%2C+A%3BMarkovic%2C+Z%3BJacobs%2C+K+B%3BJarvie%2C+T+P%3BHunter%2C+D%3BHoover%2C+R%3BThomas%2C+G%3BHarkins%2C+T+T%3BChanock%2C+S+J&rft.aulast=Yeager-Jeffery&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin Converting Enzyme Gene Polymorphism and Diabetic Nephropathy in Filipino Type 2 Diabetes Mellitus Patients. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40705399; 4751985 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Cutiongco, E.M.C. AU - Paz-Pacheco, E AU - Jasul, G V AU - Cruz, M.C.A. Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Enzymes KW - Diabetes mellitus KW - Nephropathy KW - Gene polymorphism KW - Peptidyl-dipeptidase A KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Angiotensin+Converting+Enzyme+Gene+Polymorphism+and+Diabetic+Nephropathy+in+Filipino+Type+2+Diabetes+Mellitus+Patients.&rft.au=Cutiongco%2C+E.M.C.%3BPaz-Pacheco%2C+E%3BJasul%2C+G+V%3BCruz%2C+M.C.A.&rft.aulast=Cutiongco&rft.aufirst=E.M.C.&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Studies of Familial Autoimmune Myasthenia Gravis. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40705321; 4751968 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Landoure, G AU - Knight, M AU - Stanescu, H AU - Taye, A AU - Kleta, R AU - Fischbeck, K H Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Myasthenia gravis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40705321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genetic+Studies+of+Familial+Autoimmune+Myasthenia+Gravis.&rft.au=Landoure%2C+G%3BKnight%2C+M%3BStanescu%2C+H%3BTaye%2C+A%3BKleta%2C+R%3BFischbeck%2C+K+H&rft.aulast=Landoure&rft.aufirst=G&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The GLUT9 Gene is Associated with Serum Uric Acid Levels in Sardinia and Chianti Cohorts. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40704760; 4752279 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Li, S. AU - Sanna, S AU - Dei, M AU - Lai, S AU - Usala, G AU - Maschio, A AU - Busonero, F AU - Mulas, A AU - Orru, M AU - Albai, G AU - Bandinelli, S AU - Schlessinger, D AU - Scuteri, A AU - Najjar, S AU - Cao, A AU - Abecasis, G AU - Ferrucci, L AU - Uda, M AU - Chen, W M AU - Nagaraja, R Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Italy, Sardegna KW - Uric acid KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=The+GLUT9+Gene+is+Associated+with+Serum+Uric+Acid+Levels+in+Sardinia+and+Chianti+Cohorts.&rft.au=Li%2C+S.%3BSanna%2C+S%3BDei%2C+M%3BLai%2C+S%3BUsala%2C+G%3BMaschio%2C+A%3BBusonero%2C+F%3BMulas%2C+A%3BOrru%2C+M%3BAlbai%2C+G%3BBandinelli%2C+S%3BSchlessinger%2C+D%3BScuteri%2C+A%3BNajjar%2C+S%3BCao%2C+A%3BAbecasis%2C+G%3BFerrucci%2C+L%3BUda%2C+M%3BChen%2C+W+M%3BNagaraja%2C+R&rft.aulast=Li&rft.aufirst=S.&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Haplotype Analysis of Prostate Cancer Susceptibility Loci at 8q24. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40704696; 4752103 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Orr, N AU - Yeager, M AU - Jacobs, K AU - Hayes, R AU - Kraft, P AU - Wacholder, S AU - Welch, R AU - Feigelson, H Spencer AU - Albanes, D AU - Gerhard, D AU - Hoover, R AU - Hunter, D AU - Thomas, G AU - Chanock, S Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Haplotypes KW - Prostate cancer KW - Chromosome 8 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Haplotype+Analysis+of+Prostate+Cancer+Susceptibility+Loci+at+8q24.&rft.au=Orr%2C+N%3BYeager%2C+M%3BJacobs%2C+K%3BHayes%2C+R%3BKraft%2C+P%3BWacholder%2C+S%3BWelch%2C+R%3BFeigelson%2C+H+Spencer%3BAlbanes%2C+D%3BGerhard%2C+D%3BHoover%2C+R%3BHunter%2C+D%3BThomas%2C+G%3BChanock%2C+S&rft.aulast=Orr&rft.aufirst=N&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variants in the FANCF Gene are Associated with Type 2 Diabetes in Pima Indians. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40704333; 4752172 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Bian, L AU - Muller, Y L AU - Hanson, R L AU - Kobes, S AU - Bogardus, C AU - Baier, L J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Diabetes mellitus KW - FANCF gene KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704333?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Variants+in+the+FANCF+Gene+are+Associated+with+Type+2+Diabetes+in+Pima+Indians.&rft.au=Bian%2C+L%3BMuller%2C+Y+L%3BHanson%2C+R+L%3BKobes%2C+S%3BBogardus%2C+C%3BBaier%2C+L+J&rft.aulast=Bian&rft.aufirst=L&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence Variants of Insulin-Secreting Pathway Genes Contributing to Type 2 Diabetes Risk in the Yakut Population of Eastern Siberia. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40704151; 4751989 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Odgerel, Z AU - Lee, H S AU - Platonov, F A AU - Sambuughin, N AU - Ignatiev, P M AU - Alekseeva, L L AU - Osakovskiy, V L AU - Sivtseva, T M AU - Krivoshapkin, V G AU - Goldfarb, L G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Russia, Siberia KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40704151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Sequence+Variants+of+Insulin-Secreting+Pathway+Genes+Contributing+to+Type+2+Diabetes+Risk+in+the+Yakut+Population+of+Eastern+Siberia.&rft.au=Odgerel%2C+Z%3BLee%2C+H+S%3BPlatonov%2C+F+A%3BSambuughin%2C+N%3BIgnatiev%2C+P+M%3BAlekseeva%2C+L+L%3BOsakovskiy%2C+V+L%3BSivtseva%2C+T+M%3BKrivoshapkin%2C+V+G%3BGoldfarb%2C+L+G&rft.aulast=Odgerel&rft.aufirst=Z&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Dysmorphologic Features of a Newborn Following an Abdominal Pregnancy. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40703710; 4752031 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Abarquez, C G AU - Alcausin, M L AU - Padilla, C D AU - E.M.C. Cutiongco-De La Paz Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Pregnancy KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40703710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=The+Dysmorphologic+Features+of+a+Newborn+Following+an+Abdominal+Pregnancy.&rft.au=Abarquez%2C+C+G%3BAlcausin%2C+M+L%3BPadilla%2C+C+D%3BE.M.C.+Cutiongco-De+La+Paz&rft.aulast=Abarquez&rft.aufirst=C&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - How Good is Whole-genome Amplified DNA for Genome-wide Association Studies? T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40702758; 4752376 DE: JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Akula, N AU - Cichon, S AU - Noethen, M AU - McMahon, F Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40702758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=How+Good+is+Whole-genome+Amplified+DNA+for+Genome-wide+Association+Studies%3F&rft.au=Akula%2C+N%3BCichon%2C+S%3BNoethen%2C+M%3BMcMahon%2C+F&rft.aulast=Akula&rft.aufirst=N&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Two Genome-Wide Association Studies Suggest DFNB31 as a Risk Locus for Bipolar Disorder. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40702619; 4751538 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Baum, A E AU - Cabanero, M AU - Akula, N AU - McMahon, F J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Bipolar disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40702619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Two+Genome-Wide+Association+Studies+Suggest+DFNB31+as+a+Risk+Locus+for+Bipolar+Disorder.&rft.au=Baum%2C+A+E%3BCabanero%2C+M%3BAkula%2C+N%3BMcMahon%2C+F+J&rft.aulast=Baum&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Locus Associated with White Blood Cell Count in the Health, Aging, and Body Composition Study. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40699464; 4750854 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Nalls, M A AU - Wilson, J G AU - Patterson, N J AU - Tandon, A AU - Zmuda, J AU - Huntsman, S AU - Hu, D. AU - Beamer, B AU - Patel, K AU - Files, J AU - Akylbekova, M AU - Hardy, C AU - Taylor, H AU - Reich, D AU - Harris, T B AU - Ziv, E Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Aging KW - Leukocytes KW - Body composition KW - Blood cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genetic+Locus+Associated+with+White+Blood+Cell+Count+in+the+Health%2C+Aging%2C+and+Body+Composition+Study.&rft.au=Nalls%2C+M+A%3BWilson%2C+J+G%3BPatterson%2C+N+J%3BTandon%2C+A%3BZmuda%2C+J%3BHuntsman%2C+S%3BHu%2C+D.%3BBeamer%2C+B%3BPatel%2C+K%3BFiles%2C+J%3BAkylbekova%2C+M%3BHardy%2C+C%3BTaylor%2C+H%3BReich%2C+D%3BHarris%2C+T+B%3BZiv%2C+E&rft.aulast=Nalls&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype-Phenotype Relationships in Desminopathy. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40699275; 4751440 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Lee, H AU - Shatunov, A AU - Olive, M AU - Vicart, P AU - Kaminska, A AU - Bushby, K AU - Muntoni, F AU - Dalakas, M AU - Goebel, H AU - Goldfarb, L Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Genetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699275?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genotype-Phenotype+Relationships+in+Desminopathy.&rft.au=Lee%2C+H%3BShatunov%2C+A%3BOlive%2C+M%3BVicart%2C+P%3BKaminska%2C+A%3BBushby%2C+K%3BMuntoni%2C+F%3BDalakas%2C+M%3BGoebel%2C+H%3BGoldfarb%2C+L&rft.aulast=Lee&rft.aufirst=H&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Investigating Linkage to Chromosome 10 in Familial Interstitial Pneumonia (FIP). T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40699052; 4750801 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Wise, A L AU - Speer, M C AU - Steele, M P AU - Burch, L H AU - Herron, A AU - Loyd, J E AU - Brown, K K AU - Phillips III, J.A. AU - Slifer, S H AU - Schwarz, M I AU - Schwartz, D A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Chromosomes KW - Chromosome 10 KW - Pneumonia KW - Interstitial environment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Investigating+Linkage+to+Chromosome+10+in+Familial+Interstitial+Pneumonia+%28FIP%29.&rft.au=Wise%2C+A+L%3BSpeer%2C+M+C%3BSteele%2C+M+P%3BBurch%2C+L+H%3BHerron%2C+A%3BLoyd%2C+J+E%3BBrown%2C+K+K%3BPhillips+III%2C+J.A.%3BSlifer%2C+S+H%3BSchwarz%2C+M+I%3BSchwartz%2C+D+A&rft.aulast=Wise&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conditional Linkage with the UGT1A1 Gene and Whole-Genome Association Studies of Serum Bilirubin. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40699034; 4751346 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Lin, J-P AU - Schwaiger, J P AU - Cupples, L A AU - ODonnell, C J AU - Zheng, G AU - Schoenborn, V AU - Hunt, S C AU - Kronenberg, F Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Bilirubin KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Conditional+Linkage+with+the+UGT1A1+Gene+and+Whole-Genome+Association+Studies+of+Serum+Bilirubin.&rft.au=Lin%2C+J-P%3BSchwaiger%2C+J+P%3BCupples%2C+L+A%3BODonnell%2C+C+J%3BZheng%2C+G%3BSchoenborn%2C+V%3BHunt%2C+S+C%3BKronenberg%2C+F&rft.aulast=Lin&rft.aufirst=J-P&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A High-Density SNP Genome-Wide Linkage Search of 206 Families Identifies Susceptibility Loci for Chronic Lymphocytic Leukemia. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40698371; 4750818 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Goldin, L R AU - Sellick, G S AU - Wild, R W AU - Slager, S L AU - Catovsky, D AU - Caporaso, N AU - Houlston, R S Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Chronic lymphatic leukemia KW - Single-nucleotide polymorphism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=A+High-Density+SNP+Genome-Wide+Linkage+Search+of+206+Families+Identifies+Susceptibility+Loci+for+Chronic+Lymphocytic+Leukemia.&rft.au=Goldin%2C+L+R%3BSellick%2C+G+S%3BWild%2C+R+W%3BSlager%2C+S+L%3BCatovsky%2C+D%3BCaporaso%2C+N%3BHoulston%2C+R+S&rft.aulast=Goldin&rft.aufirst=L&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Whole Genome Scan Revealed Responsible Loci for Responses to Short Term Analgesics in Humans. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40698209; 4750693 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Kim, H AU - Ramsay, E AU - Wahl, S AU - Dionne, R A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Genomes KW - Analgesics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Whole+Genome+Scan+Revealed+Responsible+Loci+for+Responses+to+Short+Term+Analgesics+in+Humans.&rft.au=Kim%2C+H%3BRamsay%2C+E%3BWahl%2C+S%3BDionne%2C+R+A&rft.aulast=Kim&rft.aufirst=H&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maple Syrup Urine Disease: Mutation analysis in Filipino Patients using the COPPER Plate System. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40696903; 4751182 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Silao, C.L.T AU - Samejima, H AU - Torii, C AU - Padilla, C AU - Kosaki, K AU - Matsuo, M Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Copper KW - Mutation KW - Urine KW - Maple syrup urine disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40696903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Maple+Syrup+Urine+Disease%3A+Mutation+analysis+in+Filipino+Patients+using+the+COPPER+Plate+System.&rft.au=Silao%2C+C.L.T%3BSamejima%2C+H%3BTorii%2C+C%3BPadilla%2C+C%3BKosaki%2C+K%3BMatsuo%2C+M&rft.aulast=Silao&rft.aufirst=C.L.T&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transgenic Mice for 4 BP Deletion Mutation in DLX3 Gene Cause Severe Taurodontism in Tooth Development. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40696592; 4750640 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Hart, T C AU - Lee, S K AU - Feng, J Q AU - Choi, S J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Mutation KW - Mice KW - Teeth KW - Gene deletion KW - Dlx3 gene KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40696592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Transgenic+Mice+for+4+BP+Deletion+Mutation+in+DLX3+Gene+Cause+Severe+Taurodontism+in+Tooth+Development.&rft.au=Hart%2C+T+C%3BLee%2C+S+K%3BFeng%2C+J+Q%3BChoi%2C+S+J&rft.aulast=Hart&rft.aufirst=T&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Newly Recognized Overgrowth Syndrome Distinct from Proteus Syndrome. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40695896; 4750256 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Sapp, J C AU - Clark, R D AU - Turner, J T AU - van de Kamp, J AU - van Dijk, F AU - Lowry, R B AU - Biesecker, L G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=A+Newly+Recognized+Overgrowth+Syndrome+Distinct+from+Proteus+Syndrome.&rft.au=Sapp%2C+J+C%3BClark%2C+R+D%3BTurner%2C+J+T%3Bvan+de+Kamp%2C+J%3Bvan+Dijk%2C+F%3BLowry%2C+R+B%3BBiesecker%2C+L+G&rft.aulast=Sapp&rft.aufirst=J&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Form of Cerebellar Ataxia with Increased Free Sialic Acid in Cerebrospinal Fluid. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40695410; 4749684 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Mochel, F AU - Sedel, F AU - Engelke, U.F.H. AU - Barritault, J AU - Morava, E AU - Timmons, M AU - Seguin, F AU - Brice, A AU - Schiffmann, R AU - Durr, A AU - Wevers, R A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Cerebrospinal fluid KW - Sialic acids KW - Cerebellar ataxia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40695410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=A+Novel+Form+of+Cerebellar+Ataxia+with+Increased+Free+Sialic+Acid+in+Cerebrospinal+Fluid.&rft.au=Mochel%2C+F%3BSedel%2C+F%3BEngelke%2C+U.F.H.%3BBarritault%2C+J%3BMorava%2C+E%3BTimmons%2C+M%3BSeguin%2C+F%3BBrice%2C+A%3BSchiffmann%2C+R%3BDurr%2C+A%3BWevers%2C+R+A&rft.aulast=Mochel&rft.aufirst=F&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - ARG Analysis in the Genome Wide Association Scans of the Cancer Genetic Marker of Susceptibility Initiative. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694955; 4751069 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Wang, Z AU - Yeager, M AU - Jacobs, K B AU - Minichiello, M AU - Orr, N AU - Hoover, R AU - Hunter, D J AU - Chanock, S J AU - Thomas, G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Cancer KW - Genetic markers KW - Genomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=ARG+Analysis+in+the+Genome+Wide+Association+Scans+of+the+Cancer+Genetic+Marker+of+Susceptibility+Initiative.&rft.au=Wang%2C+Z%3BYeager%2C+M%3BJacobs%2C+K+B%3BMinichiello%2C+M%3BOrr%2C+N%3BHoover%2C+R%3BHunter%2C+D+J%3BChanock%2C+S+J%3BThomas%2C+G&rft.aulast=Wang&rft.aufirst=Z&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Outcomes in Menkes Disease Patients with a Potentially Treatment-Responsive ATP7A Mutation, G727R. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694419; 4751123 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Tang, J R AU - Donsante, A AU - Kaler, S G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Mutation KW - Menkes disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Clinical+Outcomes+in+Menkes+Disease+Patients+with+a+Potentially+Treatment-Responsive+ATP7A+Mutation%2C+G727R.&rft.au=Tang%2C+J+R%3BDonsante%2C+A%3BKaler%2C+S+G&rft.aulast=Tang&rft.aufirst=J&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New Paradigm for the Inheritance of Familial Mediterranean Fever (FMF). T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694396; 4750738 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Aksentijevich, I AU - Booty, M G AU - Remmers, E F AU - Kastner, D L Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - MED KW - Familial Mediterranean fever KW - Heredity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=A+New+Paradigm+for+the+Inheritance+of+Familial+Mediterranean+Fever+%28FMF%29.&rft.au=Aksentijevich%2C+I%3BBooty%2C+M+G%3BRemmers%2C+E+F%3BKastner%2C+D+L&rft.aulast=Aksentijevich&rft.aufirst=I&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Evaluation of Three Novel Small Molecule Classes Identified through Quantitative High-Throughput Screening (qHTS) as Potential Chaperones for Gaucher Disease. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694351; 4751894 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Urban, D J AU - Zheng, W AU - Goker-Alpan, O AU - Goldin, E AU - Inglese, J AU - Austin, C AU - Sidransky, E Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Chaperones KW - Gaucher's disease KW - High-throughput screening KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=The+Evaluation+of+Three+Novel+Small+Molecule+Classes+Identified+through+Quantitative+High-Throughput+Screening+%28qHTS%29+as+Potential+Chaperones+for+Gaucher+Disease.&rft.au=Urban%2C+D+J%3BZheng%2C+W%3BGoker-Alpan%2C+O%3BGoldin%2C+E%3BInglese%2C+J%3BAustin%2C+C%3BSidransky%2C+E&rft.aulast=Urban&rft.aufirst=D&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Correlation between Dried Blood Spot Thin Layer Chromatography and Plasma High Performance Liquid Chromatography of Leucine/Isoleucine Levelsamong Filipino Patients with Maple Syrup Urine Disease. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694224; 4751099 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Padilla, C D AU - Lee, J Y AU - Demata, M A AU - Cruz, K.T. Dela AU - Chiong, M D AU - Cavan, C C Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Liquid chromatography KW - Chromatography KW - Urine KW - Blood KW - Isoleucine KW - High-performance liquid chromatography KW - Maple syrup urine disease KW - Leucine KW - Serological studies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Correlation+between+Dried+Blood+Spot+Thin+Layer+Chromatography+and+Plasma+High+Performance+Liquid+Chromatography+of+Leucine%2FIsoleucine+Levelsamong+Filipino+Patients+with+Maple+Syrup+Urine+Disease.&rft.au=Padilla%2C+C+D%3BLee%2C+J+Y%3BDemata%2C+M+A%3BCruz%2C+K.T.+Dela%3BChiong%2C+M+D%3BCavan%2C+C+C&rft.aulast=Padilla&rft.aufirst=C&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fine-Mapping of Chromosome 19 for Total Cholesterol Levels in Pima Indians. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40694195; 4751067 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Malhotra, A AU - LeClair, C N AU - Looker, H C AU - Yeatts, K A AU - Knowler, W C AU - Hanson, R L AU - Wolford, J K Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Chromosomes KW - Chromosome 19 KW - Cholesterol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40694195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Fine-Mapping+of+Chromosome+19+for+Total+Cholesterol+Levels+in+Pima+Indians.&rft.au=Malhotra%2C+A%3BLeClair%2C+C+N%3BLooker%2C+H+C%3BYeatts%2C+K+A%3BKnowler%2C+W+C%3BHanson%2C+R+L%3BWolford%2C+J+K&rft.aulast=Malhotra&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting Deletions in Candidate Genes for Cleft Lip and Palate. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40693717; 4751068 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Shi, M AU - Jugessur, A AU - Gjessing, H AU - Wilcox, A J AU - Lie, R T AU - Weinberg, C R AU - Trung, T N AU - Christensen, K AU - Murray, J C Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Cleft lip/palate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40693717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Detecting+Deletions+in+Candidate+Genes+for+Cleft+Lip+and+Palate.&rft.au=Shi%2C+M%3BJugessur%2C+A%3BGjessing%2C+H%3BWilcox%2C+A+J%3BLie%2C+R+T%3BWeinberg%2C+C+R%3BTrung%2C+T+N%3BChristensen%2C+K%3BMurray%2C+J+C&rft.aulast=Shi&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Methods of Educating the Next Generation in Genetics and Genomics Science. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40693668; 4750463 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Harding, S E AU - Bonham, V L AU - Easter, C L AU - Lea, D H AU - Witherly, J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Genetics KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40693668?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Methods+of+Educating+the+Next+Generation+in+Genetics+and+Genomics+Science.&rft.au=Harding%2C+S+E%3BBonham%2C+V+L%3BEaster%2C+C+L%3BLea%2C+D+H%3BWitherly%2C+J&rft.aulast=Harding&rft.aufirst=S&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Natural History and Molecular Genetics of Pediatric Bilateral Testicular Tumors. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40693157; 4750269 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Collins, M T AU - Nandagopal, R AU - Merke, D P AU - Leschek, E W AU - Shawker, T AU - Libutti, S K AU - Carney, J A AU - Stratakis, C A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Genetics KW - Historical account KW - Pediatrics KW - Tumors KW - Testes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40693157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Natural+History+and+Molecular+Genetics+of+Pediatric+Bilateral+Testicular+Tumors.&rft.au=Collins%2C+M+T%3BNandagopal%2C+R%3BMerke%2C+D+P%3BLeschek%2C+E+W%3BShawker%2C+T%3BLibutti%2C+S+K%3BCarney%2C+J+A%3BStratakis%2C+C+A&rft.aulast=Collins&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Analysis of Alterations in Histone Methylation and Gene Expression in Hutchinson-Gilford Progeria Syndrome. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40693061; 4750348 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Cao, K AU - Faddah, D AU - Erdos, M R AU - Capell, B C AU - Collins, F S Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Progeria KW - Gene expression KW - Histones KW - DNA methylation KW - Methylation KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40693061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genome-Wide+Analysis+of+Alterations+in+Histone+Methylation+and+Gene+Expression+in+Hutchinson-Gilford+Progeria+Syndrome.&rft.au=Cao%2C+K%3BFaddah%2C+D%3BErdos%2C+M+R%3BCapell%2C+B+C%3BCollins%2C+F+S&rft.aulast=Cao&rft.aufirst=K&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Duplication at Chromosome 11q12.2 is Associated with Spinocerebellar Ataxia Type 20 (SCA20). T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40692529; 4750491 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Knight, M A AU - Hernandez, D AU - Rafferty, I AU - Forrest, S M AU - Gardner, R.J.M. AU - Storey, E AU - Dutra, A AU - Pak, E AU - Fischbeck, K H AU - Singleton, A B Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Chromosomes KW - Chromosome 11 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40692529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=A+Duplication+at+Chromosome+11q12.2+is+Associated+with+Spinocerebellar+Ataxia+Type+20+%28SCA20%29.&rft.au=Knight%2C+M+A%3BHernandez%2C+D%3BRafferty%2C+I%3BForrest%2C+S+M%3BGardner%2C+R.J.M.%3BStorey%2C+E%3BDutra%2C+A%3BPak%2C+E%3BFischbeck%2C+K+H%3BSingleton%2C+A+B&rft.aulast=Knight&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Association Scan for Height in 6,671 Individuals from Finland and Sardinia. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40692302; 4751800 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Sanna, S AU - Jackson, A U AU - Usala, G AU - Willer, C J AU - Dei, M AU - Bonnycastle, L L AU - Lai, S AU - Li, Y. AU - Uda, M AU - Erdos, M R AU - Shen, H AU - Shuldiner, A AU - Cao, A AU - Bergam, R M AU - Schlessinger, D AU - Collins, F S AU - Boehnke, M AU - Abecasis, G R AU - Nagaraja, R AU - Mohlke, K L Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Italy, Sardegna KW - Finland KW - Statistical genetics KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40692302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genome-Wide+Association+Scan+for+Height+in+6%2C671+Individuals+from+Finland+and+Sardinia.&rft.au=Sanna%2C+S%3BJackson%2C+A+U%3BUsala%2C+G%3BWiller%2C+C+J%3BDei%2C+M%3BBonnycastle%2C+L+L%3BLai%2C+S%3BLi%2C+Y.%3BUda%2C+M%3BErdos%2C+M+R%3BShen%2C+H%3BShuldiner%2C+A%3BCao%2C+A%3BBergam%2C+R+M%3BSchlessinger%2C+D%3BCollins%2C+F+S%3BBoehnke%2C+M%3BAbecasis%2C+G+R%3BNagaraja%2C+R%3BMohlke%2C+K+L&rft.aulast=Sanna&rft.aufirst=S&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutation Detection Rate and Genotype-Phenotype Correlations in Patients with Mutations in Ush2A, the Gene Encoding for Usherin. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40691582; 4750306 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Tsilou, E AU - Schultz, J AU - Meltzer, M R AU - Caruso, R AU - Griffith, A AU - Madeo, A AU - Brewer, C AU - Zalewski, C AU - Friedman, T Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Mutation KW - USH2A protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40691582?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Mutation+Detection+Rate+and+Genotype-Phenotype+Correlations+in+Patients+with+Mutations+in+Ush2A%2C+the+Gene+Encoding+for+Usherin.&rft.au=Tsilou%2C+E%3BSchultz%2C+J%3BMeltzer%2C+M+R%3BCaruso%2C+R%3BGriffith%2C+A%3BMadeo%2C+A%3BBrewer%2C+C%3BZalewski%2C+C%3BFriedman%2C+T&rft.aulast=Tsilou&rft.aufirst=E&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adenoviral Mediated Gene Delivery Rescues a Neonatal Lethal Murine Model of Mut0 Methylmalonic Acidemiamut0. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40691062; 4751925 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Chandler, R J AU - Venditti, C P Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Gene transfer KW - Animal models KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40691062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Adenoviral+Mediated+Gene+Delivery+Rescues+a+Neonatal+Lethal+Murine+Model+of+Mut0+Methylmalonic+Acidemiamut0.&rft.au=Chandler%2C+R+J%3BVenditti%2C+C+P&rft.aulast=Chandler&rft.aufirst=R&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Association Study of Treatment Emergent Suicidal Ideation in the STAR*D Sample. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690986; 4750696 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Laje, G AU - Akula, N AU - Allen, A S AU - Paddock, S AU - Manji, H K AU - Rush, A J AU - Charney, D AU - McMahon, F J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Suicide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Genome-Wide+Association+Study+of+Treatment+Emergent+Suicidal+Ideation+in+the+STAR*D+Sample.&rft.au=Laje%2C+G%3BAkula%2C+N%3BAllen%2C+A+S%3BPaddock%2C+S%3BManji%2C+H+K%3BRush%2C+A+J%3BCharney%2C+D%3BMcMahon%2C+F+J&rft.aulast=Laje&rft.aufirst=G&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Genomic Locus Associated with Early Onset Familial Essential Tremor. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690954; 4751063 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Shatunov, A AU - Mari, Z AU - Peckham, E AU - Elble, R AU - Clarimon, J AU - Sambuughin, N AU - Lee, H S AU - Singleton, A B AU - Vojcic, D AU - Hallett, M AU - Goldfarb, L G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Tremor KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690954?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Identification+of+a+Genomic+Locus+Associated+with+Early+Onset+Familial+Essential+Tremor.&rft.au=Shatunov%2C+A%3BMari%2C+Z%3BPeckham%2C+E%3BElble%2C+R%3BClarimon%2C+J%3BSambuughin%2C+N%3BLee%2C+H+S%3BSingleton%2C+A+B%3BVojcic%2C+D%3BHallett%2C+M%3BGoldfarb%2C+L+G&rft.aulast=Shatunov&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population Structure in European American Populations - Impact on the Design and Analysis of Genome-Wide Association Studies (GWAS). T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690501; 4749743 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Yu, K. AU - Wang, Z M AU - Li, Q Z AU - Wacholder, S AU - Hoover, R AU - Hunter, D AU - Chanock, S AU - Thomas, G Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Population structure KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Population+Structure+in+European+American+Populations+-+Impact+on+the+Design+and+Analysis+of+Genome-Wide+Association+Studies+%28GWAS%29.&rft.au=Yu%2C+K.%3BWang%2C+Z+M%3BLi%2C+Q+Z%3BWacholder%2C+S%3BHoover%2C+R%3BHunter%2C+D%3BChanock%2C+S%3BThomas%2C+G&rft.aulast=Yu&rft.aufirst=K.&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrated Genetic and Epigenetic Studies of Breast Cancer Progression and Metastasis Using Affymetrix SNP Chips. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690439; 4750111 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Lee, M AU - Diaz-Meyer, N AU - Kadota, M AU - Yang, H AU - Lin, W Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Breast cancer KW - Single-nucleotide polymorphism KW - Epigenetics KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Integrated+Genetic+and+Epigenetic+Studies+of+Breast+Cancer+Progression+and+Metastasis+Using+Affymetrix+SNP+Chips.&rft.au=Lee%2C+M%3BDiaz-Meyer%2C+N%3BKadota%2C+M%3BYang%2C+H%3BLin%2C+W&rft.aulast=Lee&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The National Ophthalmic Disease Genotyping Network: eyeGENE@@uTM@. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690028; 4750439 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Tumminia, S J AU - Nezhuvingal, A AU - Scheim, D AU - Smaoui, N AU - Blain, D AU - Chin, H AU - Brooks, B P Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Genotyping KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=The+National+Ophthalmic+Disease+Genotyping+Network%3A+eyeGENE%40%40uTM%40.&rft.au=Tumminia%2C+S+J%3BNezhuvingal%2C+A%3BScheim%2C+D%3BSmaoui%2C+N%3BBlain%2C+D%3BChin%2C+H%3BBrooks%2C+B+P&rft.aulast=Tumminia&rft.aufirst=S&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Machine Learning Methods for Detection of Epistasis under Low Penetrance. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40690014; 4751813 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Nicodemus, K K AU - Shugart, Y Y Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Epistasis KW - Learning algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40690014?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Machine+Learning+Methods+for+Detection+of+Epistasis+under+Low+Penetrance.&rft.au=Nicodemus%2C+K+K%3BShugart%2C+Y+Y&rft.aulast=Nicodemus&rft.aufirst=K&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Miglustat Improves Function and Enhances b-Galactosidase Activity in a Patient with Juvenile GM1 Gangliosidosis: A Pharmacologic Chaperone Effect? T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40689989; 4751885 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Morgan, C P AU - Adams, D R AU - Tifft, C J Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - B-Galactosidase KW - Gangliosidosis KW - Chaperones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Miglustat+Improves+Function+and+Enhances+b-Galactosidase+Activity+in+a+Patient+with+Juvenile+GM1+Gangliosidosis%3A+A+Pharmacologic+Chaperone+Effect%3F&rft.au=Morgan%2C+C+P%3BAdams%2C+D+R%3BTifft%2C+C+J&rft.aulast=Morgan&rft.aufirst=C&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detecting Associations under Models of Complex Traits Prone to an Effect Reversal. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40689717; 4751695 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Zaykin, D V AU - Shibata, K AU - Diatchenko, L Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Detecting+Associations+under+Models+of+Complex+Traits+Prone+to+an+Effect+Reversal.&rft.au=Zaykin%2C+D+V%3BShibata%2C+K%3BDiatchenko%2C+L&rft.aulast=Zaykin&rft.aufirst=D&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Introduction of Prkar1A -/- Mouse Embryonic Fibroblasts in Nude Mice Leads to Tumor Formation: Expression Profiling Reveals Consistent Alterations in Cell Cycle Regulation Genes. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40689246; 4750105 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Boikos, S A AU - Giatzakis, C AU - Robinson-White, A AU - Tsang, K AU - Hsiao, H P AU - Wen, F AU - Patronas, Y AU - Nesterova, M AU - Stratakis, C Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Mice KW - Cell cycle KW - Embryo fibroblasts KW - Transcription KW - Tumors KW - Gene regulation KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Introduction+of+Prkar1A+-%2F-+Mouse+Embryonic+Fibroblasts+in+Nude+Mice+Leads+to+Tumor+Formation%3A+Expression+Profiling+Reveals+Consistent+Alterations+in+Cell+Cycle+Regulation+Genes.&rft.au=Boikos%2C+S+A%3BGiatzakis%2C+C%3BRobinson-White%2C+A%3BTsang%2C+K%3BHsiao%2C+H+P%3BWen%2C+F%3BPatronas%2C+Y%3BNesterova%2C+M%3BStratakis%2C+C&rft.aulast=Boikos&rft.aufirst=S&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Replication of a Genome-Wide Mapping Case-Control Study in Esophageal Cancer. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40689022; 4750062 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Ng, D. AU - Hu, N. AU - Hu, Y. AU - Giffen, C AU - Tang, Z Z AU - Han, X Y AU - Yang, H H AU - Lee, M P AU - Goldstein, A M AU - Taylor, P R Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Cancer KW - Gene mapping KW - Replication KW - Esophagus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Replication+of+a+Genome-Wide+Mapping+Case-Control+Study+in+Esophageal+Cancer.&rft.au=Ng%2C+D.%3BHu%2C+N.%3BHu%2C+Y.%3BGiffen%2C+C%3BTang%2C+Z+Z%3BHan%2C+X+Y%3BYang%2C+H+H%3BLee%2C+M+P%3BGoldstein%2C+A+M%3BTaylor%2C+P+R&rft.aulast=Ng&rft.aufirst=D.&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of BDNF Haploin Sufficiency with Childhood Overweight in WAGR Syndrome. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40688736; 4750239 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Han, J C AU - Menzie, C M AU - Sanford, E L AU - Adler-Wailes, D C AU - Raygada, M J AU - Jones, M AU - Lacbawan, F L AU - Rennert, O M AU - Yanovski, J A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Children KW - Brain-derived neurotrophic factor KW - Body weight KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40688736?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Association+of+BDNF+Haploin+Sufficiency+with+Childhood+Overweight+in+WAGR+Syndrome.&rft.au=Han%2C+J+C%3BMenzie%2C+C+M%3BSanford%2C+E+L%3BAdler-Wailes%2C+D+C%3BRaygada%2C+M+J%3BJones%2C+M%3BLacbawan%2C+F+L%3BRennert%2C+O+M%3BYanovski%2C+J+A&rft.aulast=Han&rft.aufirst=J&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Early Interstitial Lung Disease in Familial Pulmonary Fibrosis. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40688703; 4750284 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Gochuico, B R AU - Ren, P AU - Avila, N A AU - Chow, C K AU - Franks, T J AU - Travis, W D AU - McCoy Jr., J.P. AU - May, R M AU - Wu, H P AU - Nguyen, D M AU - Arcos-Burgos, M AU - MacDonald, S D AU - Rosas, I O Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Lung diseases KW - Fibrosis KW - Interstitial environment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40688703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Early+Interstitial+Lung+Disease+in+Familial+Pulmonary+Fibrosis.&rft.au=Gochuico%2C+B+R%3BRen%2C+P%3BAvila%2C+N+A%3BChow%2C+C+K%3BFranks%2C+T+J%3BTravis%2C+W+D%3BMcCoy+Jr.%2C+J.P.%3BMay%2C+R+M%3BWu%2C+H+P%3BNguyen%2C+D+M%3BArcos-Burgos%2C+M%3BMacDonald%2C+S+D%3BRosas%2C+I+O&rft.aulast=Gochuico&rft.aufirst=B&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Social Support, Communal Coping and Psychological Status in Sisters in Hereditary Breast and Ovarian Cancer (HBOC) Families. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40688170; 4749765 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Peters, J A AU - Koehly, L AU - Hoskins, L AU - Kuhn, N AU - Letocha, A AU - Kenen, R AU - Loud, J AU - Greene, M H Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Ovarian cancer KW - Psychology KW - Social interactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40688170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Social+Support%2C+Communal+Coping+and+Psychological+Status+in+Sisters+in+Hereditary+Breast+and+Ovarian+Cancer+%28HBOC%29+Families.&rft.au=Peters%2C+J+A%3BKoehly%2C+L%3BHoskins%2C+L%3BKuhn%2C+N%3BLetocha%2C+A%3BKenen%2C+R%3BLoud%2C+J%3BGreene%2C+M+H&rft.aulast=Peters&rft.aufirst=J&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitisinone (OrfadinR) Reduces the Massive Fractional Excretion of Homogentisic Acid in Alkaptonuria Patients. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40687892; 4751928 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Kayser, M AU - Introne, W AU - OBrien, K AU - Bernardini, I AU - Kleta, R AU - Gahl, W Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Excretion KW - Alkaptonuria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40687892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Nitisinone+%28OrfadinR%29+Reduces+the+Massive+Fractional+Excretion+of+Homogentisic+Acid+in+Alkaptonuria+Patients.&rft.au=Kayser%2C+M%3BIntrone%2C+W%3BOBrien%2C+K%3BBernardini%2C+I%3BKleta%2C+R%3BGahl%2C+W&rft.aulast=Kayser&rft.aufirst=M&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissociation between Gonadarche and Adrenarche in Patients with Glycogen Storage Disease Type 1a. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40686215; 4750128 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Stratakis, C A AU - Boikos, S A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Storage KW - Glycogenosis KW - Glycogen KW - Dissociation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40686215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Dissociation+between+Gonadarche+and+Adrenarche+in+Patients+with+Glycogen+Storage+Disease+Type+1a.&rft.au=Stratakis%2C+C+A%3BBoikos%2C+S+A&rft.aulast=Stratakis&rft.aufirst=C&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Constitutional Cytogenetic Analysis in Men with Familial Testicular Germ Cell Tumor. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40685518; 4749972 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Mueller, C M AU - Korde, L AU - Peters, J AU - Greene, M H Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Tumors KW - Germ cells KW - Testes KW - Cytogenetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40685518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Constitutional+Cytogenetic+Analysis+in+Men+with+Familial+Testicular+Germ+Cell+Tumor.&rft.au=Mueller%2C+C+M%3BKorde%2C+L%3BPeters%2C+J%3BGreene%2C+M+H&rft.aulast=Mueller&rft.aufirst=C&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Carrier Frequency of Recurring Mutation Causing Severe/Lethal Recessive Type VIII Osteogenesis Imperfecta in African-Americans. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40685435; 4749881 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Cabral, W A AU - Barnes, A M AU - Porter, F D AU - Marini, J C Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Africa KW - Mutation KW - Osteogenesis imperfecta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40685435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=Carrier+Frequency+of+Recurring+Mutation+Causing+Severe%2FLethal+Recessive+Type+VIII+Osteogenesis+Imperfecta+in+African-Americans.&rft.au=Cabral%2C+W+A%3BBarnes%2C+A+M%3BPorter%2C+F+D%3BMarini%2C+J+C&rft.aulast=Cabral&rft.aufirst=W&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PDE8B, Encoding a High Affinity cAMP Phosphodiesterase, is Mutant in Micronodular Adrenocortical Hyperplasia. T2 - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AN - 40684450; 4749921 JF - 2007 International Conference of the American Society of Human Genetics (ASHG 2007) AU - Horvath, A AU - Giatzakis, C AU - Levine, E AU - Osorio, P AU - Robinson-White, A AU - Tzang, K AU - Boikos, S AU - Nesterova, M AU - Stratakis, C A Y1 - 2007/10/23/ PY - 2007 DA - 2007 Oct 23 KW - Mutants KW - Affinity KW - Phosphodiesterase KW - Hyperplasia KW - Cyclic AMP KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40684450?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.atitle=PDE8B%2C+Encoding+a+High+Affinity+cAMP+Phosphodiesterase%2C+is+Mutant+in+Micronodular+Adrenocortical+Hyperplasia.&rft.au=Horvath%2C+A%3BGiatzakis%2C+C%3BLevine%2C+E%3BOsorio%2C+P%3BRobinson-White%2C+A%3BTzang%2C+K%3BBoikos%2C+S%3BNesterova%2C+M%3BStratakis%2C+C+A&rft.aulast=Horvath&rft.aufirst=A&rft.date=2007-10-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Conference+of+the+American+Society+of+Human+Genetics+%28ASHG+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ashg.org/genetics/ashg/annmeet/2007/call/call-00.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Heat map visualization of high-density clinical chemistry data. AN - 68425593; 17652165 AB - Clinical chemistry data are routinely generated as part of preclinical animal toxicity studies and human clinical studies. With large-scale studies involving hundreds or even thousands of samples in multiple treatment groups, it is currently difficult to interpret the resulting complex, high-density clinical chemistry data. Accordingly, we conducted this study to investigate methods for easy visualization of complex, high-density data. Clinical chemistry data were obtained from male rats each treated with one of eight different acute hepatotoxicants from a large-scale toxicogenomics study. The raw data underwent a Z-score transformation comparing each individual animal's clinical chemistry values to that of reference controls from all eight studies and then were visualized in a single graphic using a heat map. The utility of using a heat map to visualize high-density clinical chemistry data was explored by clustering changes in clinical chemistry values for >400 animals. A clear distinction was observed in animals displaying hepatotoxicity from those that did not. Additionally, while animals experiencing hepatotoxicity showed many similarities in the observed clinical chemistry alterations, distinct differences were noted in the heat map profile for the different compounds. Using a heat map to visualize complex, high-density clinical chemistry data in a single graphic facilitates the identification of previously unrecognized trends. This method is simple to implement and maintains the biological integrity of the data. The value of this clinical chemistry data transformation and visualization will manifest itself through integration with other high-density data, such as genomics data, to study physiology at the systems level. JF - Physiological genomics AU - Auman, J Todd AU - Boorman, Gary A AU - Wilson, Ralph E AU - Travlos, Gregory S AU - Paules, Richard S AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Y1 - 2007/10/22/ PY - 2007 DA - 2007 Oct 22 SP - 352 EP - 356 VL - 31 IS - 2 KW - Index Medicus KW - Rats KW - Chemical and Drug Induced Liver Injury -- blood KW - Animals KW - Rats, Inbred F344 KW - Liver Function Tests KW - Cluster Analysis KW - Male KW - Color KW - Computer Graphics KW - Clinical Chemistry Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68425593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physiological+genomics&rft.atitle=Heat+map+visualization+of+high-density+clinical+chemistry+data.&rft.au=Auman%2C+J+Todd%3BBoorman%2C+Gary+A%3BWilson%2C+Ralph+E%3BTravlos%2C+Gregory+S%3BPaules%2C+Richard+S&rft.aulast=Auman&rft.aufirst=J&rft.date=2007-10-22&rft.volume=31&rft.issue=2&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Physiological+genomics&rft.issn=1531-2267&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2002 Jan;110(1):A8-10 [11781174] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] Environ Health Perspect. 2003 May;111(6):A338-9 [12760838] Clin Chem. 1975 Dec;21(13):1873-7 [1192578] Toxicol Pathol. 2006;34(7):921-8 [17178692] J Nutr. 1997 May;127(5 Suppl):842S-846S [9164250] Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14863-8 [9843981] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] Toxicol Appl Pharmacol. 1991 Jul;109(3):472-81 [1853346] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2. AN - 68338529; 17850816 AB - O-Glycan biosynthesis is initiated by the transfer of N-acetylgalactosamine (GalNAc) from a nucleotide sugar donor (UDP-GalNAc) to Ser/Thr residues of an acceptor substrate. The detailed transfer mechanism, catalyzed by the UDP-GalNAc polypeptide:N-acetyl-alpha-galactosaminyltransferases (ppGalNAcTs), remains unclear despite structural information available for several isoforms in complex with substrates at various stages along the catalytic pathway. We used all-atom molecular dynamics simulations with explicit solvent and counterions to study the conformational dynamics of ppGalNAcT-2 in several enzymatic states along the catalytic pathway. ppGalNAcT-2 is simulated both in the presence and in the absence of substrates and reaction products to examine the role of conformational changes in ligand binding. In multiple 40-ns-long simulations of more than 600 ns total run time, we studied systems ranging from 45,000 to 95,000 atoms. Our simulations accurately identified dynamically active regions of the protein, as previously revealed by the X-ray structures, and permitted a detailed, atomistic description of the conformational changes of loops near the active site and the characterization of the ensemble of structures adopted by the transferase complex on the transition pathway between the ligand-bound and ligand-free states. In particular, the conformational transition of a functional loop adjacent to the active site from closed (active) to open (inactive) is correlated with the rotameric state of the conserved residue W331. Analysis of water dynamics in the active site revealed that internal water molecules have an important role in enhancing the enzyme flexibility. We also found evidence that charged side chains in the active site rearrange during site opening to facilitate ligand binding. Our results are consistent with the single-displacement transfer mechanism previously proposed for ppGalNAcTs based on X-ray structures and mutagenesis data and provide new evidence for possible functional roles of certain amino acids conserved across several isoforms. JF - Journal of molecular biology AU - Milac, A L AU - Buchete, N V AU - Fritz, T A AU - Hummer, G AU - Tabak, L A AD - Section on Biological Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/10/19/ PY - 2007 DA - 2007 Oct 19 SP - 439 EP - 451 VL - 373 IS - 2 SN - 0022-2836, 0022-2836 KW - Ligands KW - 0 KW - Water KW - 059QF0KO0R KW - Manganese KW - 42Z2K6ZL8P KW - Uridine Diphosphate N-Acetylgalactosamine KW - 7277-98-7 KW - N-Acetylgalactosaminyltransferases KW - EC 2.4.1.- KW - Index Medicus KW - Water -- metabolism KW - Manganese -- metabolism KW - Models, Molecular KW - Kinetics KW - Water -- chemistry KW - Manganese -- chemistry KW - Crystallography, X-Ray KW - Structure-Activity Relationship KW - Protein Conformation KW - Binding Sites KW - N-Acetylgalactosaminyltransferases -- metabolism KW - Uridine Diphosphate N-Acetylgalactosamine -- chemistry KW - N-Acetylgalactosaminyltransferases -- chemistry KW - Uridine Diphosphate N-Acetylgalactosamine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Substrate-induced+conformational+changes+and+dynamics+of+UDP-N-acetylgalactosamine%3Apolypeptide+N-acetylgalactosaminyltransferase-2.&rft.au=Milac%2C+A+L%3BBuchete%2C+N+V%3BFritz%2C+T+A%3BHummer%2C+G%3BTabak%2C+L+A&rft.aulast=Milac&rft.aufirst=A&rft.date=2007-10-19&rft.volume=373&rft.issue=2&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Annu Rev Biophys Biomol Struct. 2000;29:291-325 [10940251] Biochemistry. 2000 Oct 3;39(39):12076-82 [11009623] EMBO J. 2001 Feb 15;20(4):638-49 [11179209] Nat Struct Biol. 2001 Feb;8(2):166-75 [11175908] J Mol Biol. 2001 Jun 29;310(1):205-18 [11419947] Eur J Biochem. 2001 Oct;268(20):5365-74 [11606199] J Biol Chem. 2001 Dec 21;276(51):48608-14 [11592969] J Mol Biol. 2001 Oct 19;313(2):317-42 [11800560] J Biol Chem. 2002 Aug 2;277(31):28310-8 [12011052] Nat Struct Biol. 2002 Sep;9(9):685-90 [12198488] Chem Biol. 2002 Dec;9(12):1337-46 [12498887] Glycobiology. 2003 Jan;13(1):1R-16R [12634319] Biochemistry. 2003 Apr 8;42(13):3674-87 [12667057] J Biol Chem. 2003 Apr 18;278(16):14420-8 [12562774] J Mol Biol. 2003 Aug 29;331(5):1065-76 [12927542] J Mol Biol. 2003 Sep 5;332(1):143-59 [12946353] Biochemistry. 2003 Nov 25;42(46):13512-21 [14621997] J Biol Chem. 2003 Dec 5;278(49):49191-5 [12972418] Carbohydr Res. 2004 Apr 2;339(5):995-1006 [15010307] J Am Chem Soc. 2004 Jun 30;126(25):7991-8000 [15212549] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W327-31 [15215404] J Biol Chem. 2004 Jul 2;279(27):28339-44 [15075344] Curr Opin Struct Biol. 2004 Oct;14(5):593-600 [15465321] Chem Commun (Camb). 2004 Oct 21;(20):2243-8 [15489968] Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15307-12 [15486088] Proc Natl Acad Sci U S A. 1989 Sep;86(17):6562-6 [2671995] J Mol Biol. 1993 Dec 5;234(3):779-815 [8254673] J Mol Graph. 1996 Feb;14(1):33-8, 27-8 [8744570] Biochemistry. 1998 Sep 15;37(37):12811-7 [9737858] EMBO J. 1999 Jul 1;18(13):3546-57 [10393171] EMBO J. 1999 Sep 1;18(17):4619-32 [10469642] Glycobiology. 2005 Feb;15(2):153-64 [15385431] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] J Mol Biol. 2005 Nov 4;353(4):804-21 [16213524] Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17612-7 [16301518] Glycobiology. 2006 Feb;16(2):29R-37R [16037492] J Mol Biol. 2006 Mar 31;357(3):917-27 [16473368] J Biol Chem. 2006 Mar 31;281(13):8613-9 [16434399] J Mol Biol. 2006 Jun 9;359(3):708-27 [16650853] Biochem J. 2006 Aug 1;397(3):491-500 [16640506] J Am Chem Soc. 2006 Dec 20;128(50):16030-1 [17165744] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMR analysis of [methyl-13C]methionine UvrB from Bacillus caldotenax reveals UvrB-domain 4 heterodimer formation in solution. AN - 68338309; 17822711 AB - UvrB is a central DNA damage recognition protein involved in bacterial nucleotide excision repair. Structural information has been limited by the apparent disorder of the C-terminal domain 4 in crystal structures of intact UvrB; in solution, the isolated domain 4 is found to form a helix-loop-helix dimer. In order to gain insight into the behavior of UvrB in solution, we have performed NMR studies on [methyl-13C]methionine-labeled UvrB from Bacillus caldotenax (molecular mass=75 kDa). The 13 methyl resonances were assigned on the basis of site-directed mutagenesis and domain deletion. Solvent accessibility was assessed based on the relaxation and chemical shift responses of the probe methyl resonances to the stable nitroxide, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPOL). M632, located at the potential dimer interface of domain 4, provides an ideal probe for UvrB dimerization behavior. The M632 resonance of UvrB is very broad, consistent with some degree of monomer-dimer exchange and/or conformational instability of the exposed dimer interface. Upon addition of unlabeled domain 4 peptide, the M632 resonance of UvrB sharpens and shifts to a position consistent with a UvrB-domain 4 heterodimer. A dissociation constant (KD) value of 3.3 microM for the binding constant of UvrB with the domain 4 peptide was derived from surface plasmon resonance studies. Due to the flexibility of the domain 3-4 linker, inferred from limited proteolysis data and from the relaxation behavior of linker residue M607, the position of domain 4 is constrained not by the stiffness of the linking segment but by direct interactions with domains 1-3 in UvrB. In summary, UvrB homodimerization is disfavored, while domain 4 homodimerization and UvrB-domain 4 heterodimerization are allowed. JF - Journal of molecular biology AU - DellaVecchia, Matthew J AU - Merritt, W Keither AU - Peng, Ye AU - Kirby, Thomas W AU - DeRose, Eugene F AU - Mueller, Geoffrey A AU - Van Houten, Bennett AU - London, Robert E AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. Y1 - 2007/10/19/ PY - 2007 DA - 2007 Oct 19 SP - 282 EP - 295 VL - 373 IS - 2 SN - 0022-2836, 0022-2836 KW - Bacterial Proteins KW - 0 KW - Carbon Isotopes KW - Solutions KW - Methionine KW - AE28F7PNPL KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Dimerization KW - Surface Plasmon Resonance KW - Methionine -- metabolism KW - Protein Structure, Tertiary KW - Models, Biological KW - Methionine -- chemistry KW - Binding Sites KW - DNA Repair Enzymes -- metabolism KW - Bacillus -- enzymology KW - Bacterial Proteins -- chemistry KW - Bacterial Proteins -- metabolism KW - DNA Repair Enzymes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=NMR+analysis+of+%5Bmethyl-13C%5Dmethionine+UvrB+from+Bacillus+caldotenax+reveals+UvrB-domain+4+heterodimer+formation+in+solution.&rft.au=DellaVecchia%2C+Matthew+J%3BMerritt%2C+W+Keither%3BPeng%2C+Ye%3BKirby%2C+Thomas+W%3BDeRose%2C+Eugene+F%3BMueller%2C+Geoffrey+A%3BVan+Houten%2C+Bennett%3BLondon%2C+Robert+E&rft.aulast=DellaVecchia&rft.aufirst=Matthew&rft.date=2007-10-19&rft.volume=373&rft.issue=2&rft.spage=282&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 1999 Dec 10;294(4):967-79 [10588900] J Biol Chem. 2006 Jun 2;281(22):15227-37 [16595666] FEBS Lett. 2000 Jan 14;465(2-3):161-4 [10631326] Mutat Res. 2000 Aug 30;460(3-4):277-300 [10946234] Res Microbiol. 2001 Apr-May;152(3-4):401-9 [11421287] J Biomol Struct Dyn. 2001 Oct;19(2):219-36 [11697728] J Biol Chem. 2002 Jan 11;277(2):1553-9 [11687584] J Am Chem Soc. 2002 Jan 23;124(3):372-3 [11792196] Science. 2002 Mar 15;295(5562):2103-5 [11896282] EMBO J. 2002 Aug 1;21(15):4196-205 [12145219] Biochemistry. 2003 Jan 21;42(2):562-70 [12525185] J Biomol NMR. 2004 Jul;29(3):363-8 [15213434] EMBO J. 2004 Jul 7;23(13):2498-509 [15192705] Biochemistry. 2004 Jul 20;43(28):8911-22 [15248749] J Am Chem Soc. 2003 Jul 30;125(30):9004-5 [15369343] J Biol Chem. 2004 Oct 22;279(43):45245-56 [15308661] Nucleic Acids Res. 1988 Nov 25;16(22):10891-902 [2974538] Methods Enzymol. 1989;177:44-73 [2691846] Microbiol Rev. 1990 Mar;54(1):18-51 [2181258] Biochemistry. 1990 Oct 30;29(43):10041-8 [2176860] J Mol Biol. 1992 Apr 5;224(3):659-70 [1314901] Eur J Biochem. 1995 Jan 15;227(1-2):78-86 [7851445] J Biomol NMR. 1995 Nov;6(3):277-93 [8520220] J Biol Chem. 1995 Dec 22;270(51):30508-15 [8530482] Biophys J. 1997 Jul;73(1):382-96 [9199802] J Biol Chem. 1997 Sep 5;272(36):22703-13 [9278428] Mutat Res. 1997 Dec;385(3):195-203 [9506888] J Biol Chem. 1999 Mar 26;274(13):8411-20 [10085072] FEBS Lett. 1999 May 21;451(2):181-5 [10371161] Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11717-22 [10518516] Nat Rev Cancer. 2005 Jul;5(7):564-73 [16069818] Mutat Res. 2005 Sep 4;577(1-2):92-117 [15927210] Chem Rev. 2006 Feb;106(2):233-52 [16464004] J Mol Biol. 2006 Mar 17;357(1):62-72 [16426634] Nat Struct Mol Biol. 2006 Apr;13(4):360-4 [16532007] EMBO J. 1999 Dec 15;18(24):6899-907 [10601012] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Episomally Driven Antisense mRNA Abrogates the Hyperinducible Expression and Function of a Unique Cell Surface Class I Nuclease in the Primitive Trypanosomatid Parasite, Crithidia luciliae AN - 19708065; 8242739 AB - Here, we show that Crithidia luciliae, a primitive trypanosomatid, purine auxotroph, up-expressed its unique, bi-functional, surface membrane 3'-nucleotidase/nuclease (Cl 3'NT/NU) activity by ~1000-fold in response to purine starvation. A second surface membrane phospho-monoesterase, i.e. a tartrate-resistant acid phosphatase (Cl MAcP) was also found to be up-expressed in such purine-starved cells. Here, we used homologous episomal-expression of an antisense construct of the Cl3'NT/NU to dissect the functional expression of these two surface membrane enzymes. In antisense transfected cells, a large excess of the antisense transcript was produced and no trace of any endogenous Cl3'NT/NU sense message was detected. Further, the purine-starvation hyper-induced levels of 3'NT/NU enzyme activity were completely abrogated in these transfected cells versus controls. Moreover, such antisense transcription completely abolished the ability of these transfectants to grow in poly(A)-containing medium demonstrating the essential nature of the 3'NT/NU for the growth /survival of this parasite. In contrast, antisense transcription had no apparent deleterious effects on either endogenous or purine-starvation-induced levels of MAcP enzyme activity, its steady-state mRNA levels, or the constitutive expression of house-keeping genes (e.g. Cl alpha -tubulin) in these transfectants. Cumulatively, results of our antisense experiments demonstrated that the functional nuclease activity of the surface membrane Cl 3'NT/NU was, in fact, critical/essential for the growth and development of these primitive parasites. JF - Journal of Molecular Biology AU - Yamage, M AU - Joshi, M B AU - Dwyer, D M AD - Laboratory of Parasitic Diseases, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA, DDwyer@niaid.nih.gov Y1 - 2007/10/19/ PY - 2007 DA - 2007 Oct 19 SP - 296 EP - 307 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 373 IS - 2 SN - 0022-2836, 0022-2836 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - Starvation KW - Cell surface KW - Parasites KW - Auxotrophs KW - Antisense RNA KW - 3'-Nucleotidase KW - Poly(A)-containing KW - Nuclease KW - Enzymes KW - Transcription KW - purines KW - Antisense KW - Acid phosphatase (tartrate-resistant) KW - Tubulin KW - Crithidia KW - W 30905:Medical Applications KW - N 14830:RNA KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19708065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Episomally+Driven+Antisense+mRNA+Abrogates+the+Hyperinducible+Expression+and+Function+of+a+Unique+Cell+Surface+Class+I+Nuclease+in+the+Primitive+Trypanosomatid+Parasite%2C+Crithidia+luciliae&rft.au=Yamage%2C+M%3BJoshi%2C+M+B%3BDwyer%2C+D+M&rft.aulast=Yamage&rft.aufirst=M&rft.date=2007-10-19&rft.volume=373&rft.issue=2&rft.spage=296&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.08.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Starvation; Parasites; Cell surface; Auxotrophs; Antisense RNA; 3'-Nucleotidase; Transcription; Enzymes; Nuclease; Poly(A)-containing; purines; Antisense; Acid phosphatase (tartrate-resistant); Tubulin; Crithidia DO - http://dx.doi.org/10.1016/j.jmb.2007.08.014 ER - TY - JOUR T1 - Inactivation of O(6)-alkylguanine-DNA alkyltransferase by folate esters of O(6)-benzyl-2'-deoxyguanosine and of O(6)-[4-(hydroxymethyl)benzyl]guanine. AN - 68375551; 17880193 AB - O6-Alkylguanine-DNA alkyltransferase (alkyltransferase) provides an important source of resistance to some cancer chemotherapeutic alkylating agents. Folate ester derivatives of O6-benzyl-2'-deoxyguanosine and of O6-[4-(hydroxymethyl)benzyl]guanine were synthesized and tested for their ability to inactivate human alkyltransferase. Inactivation of alkyltransferase by the gamma-folate ester of O6-[4-(hydroxymethyl)benzyl]guanine was similar to that of the parent base. The gamma-folate esters of O6-benzyl-2'-deoxyguanosine were more potent alkyltransferase inactivators than the parent nucleoside. The 3'-ester was considerably more potent than the 5'-ester and was more than an order of magnitude more active than O6-benzylguanine, which is currently in clinical trials to enhance therapy with alkylating agents. They were also able to sensitize human tumor cells to killing by 1,3-bis(2-chloroethyl)-1-nitrosourea, with O6-benzyl-3'-O-(gamma-folyl)-2'-deoxyguanosine being most active. These compounds provide a new class of highly water-soluble alkyltransferase inactivators and form the basis to construct more tumor-specific and potent compounds targeting this DNA repair protein. JF - Journal of medicinal chemistry AU - Javanmard, Sahar AU - Loktionova, Natalia A AU - Fang, Qingming AU - Pauly, Gary T AU - Pegg, Anthony E AU - Moschel, Robert C AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Post Office Box B, Building 538, Frederick, Maryland 21702, USA. Y1 - 2007/10/18/ PY - 2007 DA - 2007 Oct 18 SP - 5193 EP - 5201 VL - 50 IS - 21 SN - 0022-2623, 0022-2623 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Carrier Proteins KW - Esters KW - Folate Receptors, GPI-Anchored KW - O(6)-(4-hydroxymethylbenzyl)guanine KW - Receptors, Cell Surface KW - O(6)-benzyl-2'-deoxyguanosine KW - 129732-90-7 KW - Guanine KW - 5Z93L87A1R KW - Folic Acid KW - 935E97BOY8 KW - O(6)-Methylguanine-DNA Methyltransferase KW - EC 2.1.1.63 KW - Deoxyguanosine KW - G9481N71RO KW - Carmustine KW - U68WG3173Y KW - Index Medicus KW - Receptors, Cell Surface -- metabolism KW - Solubility KW - Carrier Proteins -- metabolism KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Humans KW - Drug Resistance, Neoplasm KW - Cell Line, Tumor KW - Carmustine -- pharmacology KW - Hydrolysis KW - Structure-Activity Relationship KW - Folic Acid -- chemical synthesis KW - O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors KW - O(6)-Methylguanine-DNA Methyltransferase -- chemistry KW - Folic Acid -- analogs & derivatives KW - Folic Acid -- pharmacology KW - Guanine -- chemical synthesis KW - Guanine -- analogs & derivatives KW - Deoxyguanosine -- pharmacology KW - Deoxyguanosine -- chemical synthesis KW - Guanine -- pharmacology KW - Deoxyguanosine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68375551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medicinal+chemistry&rft.atitle=Inactivation+of+O%286%29-alkylguanine-DNA+alkyltransferase+by+folate+esters+of+O%286%29-benzyl-2%27-deoxyguanosine+and+of+O%286%29-%5B4-%28hydroxymethyl%29benzyl%5Dguanine.&rft.au=Javanmard%2C+Sahar%3BLoktionova%2C+Natalia+A%3BFang%2C+Qingming%3BPauly%2C+Gary+T%3BPegg%2C+Anthony+E%3BMoschel%2C+Robert+C&rft.aulast=Javanmard&rft.aufirst=Sahar&rft.date=2007-10-18&rft.volume=50&rft.issue=21&rft.spage=5193&rft.isbn=&rft.btitle=&rft.title=Journal+of+medicinal+chemistry&rft.issn=00222623&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nucleic Acids Res. 2000 Jan 15;28(2):393-401 [10606635] Clin Cancer Res. 2006 Mar 1;12(5):1577-84 [16533784] Mutat Res. 2000 Apr;462(2-3):83-100 [10767620] J Org Chem. 2000 Aug 11;65(16):5016-21 [10956487] Biochemistry. 2002 Jul 9;41(27):8689-97 [12093287] Nat Biotechnol. 2003 Jan;21(1):86-9 [12469133] Lancet Oncol. 2003 Jan;4(1):37-44 [12517538] Carcinogenesis. 2003 Apr;24(4):625-35 [12727789] Nat Rev Cancer. 2004 Apr;4(4):296-307 [15057289] J Med Chem. 2004 Jul 15;47(15):3887-91 [15239666] Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):9955-9 [15226507] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5368-72 [2164681] J Med Chem. 1992 Nov 13;35(23):4486-91 [1447749] Biochemistry. 1993 Nov 16;32(45):11998-2006 [8218276] J Med Chem. 1994 Feb 4;37(3):342-7 [8308861] Cancer Res. 1995 Sep 15;55(18):4085-91 [7664284] Biochem Pharmacol. 1995 Oct 12;50(8):1141-8 [7488227] Biochem Pharmacol. 1997 May 15;53(10):1559-64 [9260884] Cancer Res. 1998 May 1;58(9):1936-45 [9581836] Biochem Pharmacol. 1999 Jul 15;58(2):237-44 [10423163] J Med Chem. 2005 Jan 13;48(1):256-61 [15634019] J Clin Oncol. 2005 Oct 1;23(28):7178-87 [16192602] J Clin Oncol. 2005 Oct 20;23(30):7646-53 [16234526] EMBO J. 2000 Apr 3;19(7):1719-30 [10747039] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elemental mercury poisoning probably causes cortical myoclonus. AN - 85400078; pmid-17708573 AB - Mercury toxicity causes postural tremors, commonly referred to as "mercurial tremors," and cerebellar dysfunction. A 23-year woman, 2 years after injecting herself with elemental mercury developed disabling generalized myoclonus and ataxia. Electrophysiological studies confirmed the myoclonus was probably of cortical origin. Her deficits progressed over 2 years and improved after subcutaneous mercury deposits at the injection site were surgically cleared. Myoclonus of cortical origin has never been described in mercury poisoning. It is important to ask patients presenting with jerks about exposure to elemental mercury even if they have a progressive illness, as it is a potentially reversible condition as in our patient.2007 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Ragothaman, Mona AU - Kulkarni, Girish AU - Ashraf, Valappil V AU - Pal, Pramod K AU - Chickabasavaiah, Yasha AU - Shankar, Susarla K AU - Govindappa, Srikanth S AU - Satishchandra, Parthasarthy AU - Muthane, Uday B AD - Department of Neurology, National Institute of Mental Health & Neurosciences, Bangalore, India. Y1 - 2007/10/15/ PY - 2007 DA - 2007 Oct 15 SP - 1964 EP - 1968 VL - 22 IS - 13 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Cerebellar Ataxia: chemically induced KW - Cerebellar Ataxia: diagnosis KW - *Cerebral Cortex: drug effects KW - Disease Progression KW - Dysarthria: chemically induced KW - Dysarthria: diagnosis KW - Electromyography: drug effects KW - Epilepsy, Tonic-Clonic: chemically induced KW - Epilepsy, Tonic-Clonic: diagnosis KW - Evoked Potentials, Somatosensory: drug effects KW - Female KW - Foreign Bodies: pathology KW - Giant Cells, Foreign-Body: pathology KW - Humans KW - Injections, Intravenous KW - Mercury: administration & dosage KW - *Mercury Poisoning: diagnosis KW - Mercury Poisoning: pathology KW - *Myoclonus: chemically induced KW - Myoclonus: diagnosis KW - Psychomotor Disorders: chemically induced KW - Psychomotor Disorders: diagnosis KW - Skin: drug effects KW - Skin: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Elemental+mercury+poisoning+probably+causes+cortical+myoclonus.&rft.au=Ragothaman%2C+Mona%3BKulkarni%2C+Girish%3BAshraf%2C+Valappil+V%3BPal%2C+Pramod+K%3BChickabasavaiah%2C+Yasha%3BShankar%2C+Susarla+K%3BGovindappa%2C+Srikanth+S%3BSatishchandra%2C+Parthasarthy%3BMuthane%2C+Uday+B&rft.aulast=Ragothaman&rft.aufirst=Mona&rft.date=2007-10-15&rft.volume=22&rft.issue=13&rft.spage=1964&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Loss of hepatocyte growth factor/c-Met signaling pathway accelerates early stages of N-nitrosodiethylamine induced hepatocarcinogenesis. AN - 68403920; 17942915 AB - Hepatocyte growth factor (HGF) has been reported to have both positive and negative effects on carcinogenesis. Here, we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treated with N-nitrosodiethylamine developed significantly more and bigger tumors and with a shorter latency compared with control (w/w, AlbCre+/-; Cre-Ctrl) mice. Accelerated tumor development was associated with increased rate of cell proliferation and prolonged activation of epidermal growth factor receptor (EGFR) signaling. MetLivKO livers treated with N-nitrosodiethylamine also displayed elevated lipid peroxidation, decreased ratio of reduced glutathione to oxidized glutathione, and up-regulation of superoxide dismutase 1 and heat shock protein 70, all consistent with increased oxidative stress. Likewise, gene expression profiling done at 3 and 5 months after N-nitrosodiethylamine treatment revealed up-regulation of genes associated with cell proliferation and stress responses in c-Met mutant livers. The negative effects of c-Met deficiency were reversed by chronic p.o. administration of antioxidant N-acetyl-L-cysteine. N-acetyl-L-cysteine blocked the EGFR activation and reduced the N-nitrosodiethylamine-initiated hepatocarcinogenesis to the levels of Cre-Ctrl mice. These results argue that intact HGF/c-Met signaling is essential for maintaining normal redox homeostasis in the liver and has tumor suppressor effect(s) during the early stages of N-nitrosodiethylamine-induced hepatocarcinogenesis. JF - Cancer research AU - Takami, Taro AU - Kaposi-Novak, Pal AU - Uchida, Koichi AU - Gomez-Quiroz, Luis E AU - Conner, Elizabeth A AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4262, USA. Y1 - 2007/10/15/ PY - 2007 DA - 2007 Oct 15 SP - 9844 EP - 9851 VL - 67 IS - 20 SN - 0008-5472, 0008-5472 KW - Antioxidants KW - 0 KW - Diethylnitrosamine KW - 3IQ78TTX1A KW - Hepatocyte Growth Factor KW - 67256-21-7 KW - Proto-Oncogene Proteins c-met KW - EC 2.7.10.1 KW - Acetylcysteine KW - WYQ7N0BPYC KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Cocarcinogenesis KW - Antioxidants -- pharmacology KW - Liver -- drug effects KW - Oxidative Stress KW - Liver -- metabolism KW - Mice KW - Acetylcysteine -- pharmacology KW - Signal Transduction KW - Mice, Knockout KW - Proto-Oncogene Proteins c-met -- deficiency KW - Liver Neoplasms, Experimental -- genetics KW - Hepatocyte Growth Factor -- deficiency KW - Liver Neoplasms, Experimental -- pathology KW - Liver Neoplasms, Experimental -- metabolism KW - Proto-Oncogene Proteins c-met -- metabolism KW - Hepatocyte Growth Factor -- metabolism KW - Liver Neoplasms, Experimental -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68403920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Loss+of+hepatocyte+growth+factor%2Fc-Met+signaling+pathway+accelerates+early+stages+of+N-nitrosodiethylamine+induced+hepatocarcinogenesis.&rft.au=Takami%2C+Taro%3BKaposi-Novak%2C+Pal%3BUchida%2C+Koichi%3BGomez-Quiroz%2C+Luis+E%3BConner%2C+Elizabeth+A%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Takami&rft.aufirst=Taro&rft.date=2007-10-15&rft.volume=67&rft.issue=20&rft.spage=9844&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative measurement of endogenous estrogens and estrogen metabolites in human serum by liquid chromatography-tandem mass spectrometry. AN - 68368385; 17848096 AB - Endogenous estrogen plays a key role in the development of human breast cancer, yet the contribution of specific estrogen metabolites and patterns of estrogen metabolism remains unclear. To determine their individual and joint roles in breast carcinogenesis, it is necessary to be able to measure quantitatively each estrogen metabolite in epidemiologic and clinical biospecimens. In this report, we detail a sensitive, specific, accurate, and precise high-performance liquid chromatography-tandem mass spectrometry method utilizing selected reaction monitoring for measuring the absolute quantities of free (unconjugated) and total (conjugated + unconjugated) endogenous estrogens and estrogen metabolites in human serum from premenopausal and postmenopausal women. The method requires a simple sample preparation and only 0.5 mL of serum, yet is capable of quantifying simultaneously 15 estrogens and estrogen metabolites (EM): estrone and its 2-, 4-, and 16alpha-hydroxy and 2- and 4-methoxy derivatives; 2-hydroxyestrone-3-methyl ether; 17beta-estradiol and its 2-hydroxy and 2- and 4-methoxy derivatives; and estriol, 17-epiestriol, 16-ketoestradiol, and 16-epiestriol. The lower limit of quantitation for each EM was 0.4 pg on-column, equivalent to 8 pg/mL (26.5-29.6 fmol/mL) in the original serum sample. Calibration curves were linear over a 10(3)-fold concentration range. For a stripped serum sample containing 8 pg/mL of each EM, accuracy (percent recovery of a known added amount) ranged from 91 to 113%. Intrabatch precision (including hydrolysis, extraction, and derivatization steps) ranged from 7 to 30% relative standard deviation (RSD), and interbatch precision ranged from 8 to 29% RSD. Since distinct roles have been proposed for many of these estrogen metabolites, an accurate, precise, sensitive, and specific method for measuring their levels in circulation should suggest new approaches to breast cancer prevention, screening, and treatment. JF - Analytical chemistry AU - Xu, Xia AU - Roman, John M AU - Issaq, Haleem J AU - Keefer, Larry K AU - Veenstra, Timothy D AU - Ziegler, Regina G AD - Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. Y1 - 2007/10/15/ PY - 2007 DA - 2007 Oct 15 SP - 7813 EP - 7821 VL - 79 IS - 20 SN - 0003-2700, 0003-2700 KW - Estrogens KW - 0 KW - Ions KW - Index Medicus KW - Ions -- chemistry KW - Humans KW - Hydrolysis KW - Estrogens -- metabolism KW - Tandem Mass Spectrometry -- methods KW - Chromatography, High Pressure Liquid -- methods KW - Spectrometry, Mass, Electrospray Ionization -- methods KW - Estrogens -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+chemistry&rft.atitle=Quantitative+measurement+of+endogenous+estrogens+and+estrogen+metabolites+in+human+serum+by+liquid+chromatography-tandem+mass+spectrometry.&rft.au=Xu%2C+Xia%3BRoman%2C+John+M%3BIssaq%2C+Haleem+J%3BKeefer%2C+Larry+K%3BVeenstra%2C+Timothy+D%3BZiegler%2C+Regina+G&rft.aulast=Xu&rft.aufirst=Xia&rft.date=2007-10-15&rft.volume=79&rft.issue=20&rft.spage=7813&rft.isbn=&rft.btitle=&rft.title=Analytical+chemistry&rft.issn=00032700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DNA damage, superoxide, and mutant K-ras in human lung adenocarcinoma cells. AN - 68273477; 17854710 AB - DNA single-strand breaks (quantitative comet assay) were assessed to indicate ongoing genetic instability in a panel of human lung adenocarcinoma cell lines. Of these, 19/20 showed more DNA damage than a nontransformed cell line from human peripheral lung epithelium, HPL1D. DNA damage was significantly greater in those derived from pleural effusates vs those from lymph node metastases. DNA strand breaks correlated positively with superoxide (nitroblue tetrazolium reduction assay), and negatively with amount of OGG1, a repair enzyme for oxidative DNA damage. Levels of CuZn superoxide dismutase varied moderately among the lines and did not correlate with other parameters. A role for mutant K-ras through generation of reactive oxygen species was examined. Cells with mutant K-ras had significantly lower amounts of manganese superoxide dismutase (MnSOD) vs those with wild-type K-ras, but MnSOD protein correlated positively with superoxide levels. In a subset of cell lines with similar levels of MnSOD, comparable to those in HPL1D cells, K-ras activity correlated positively with levels of both superoxide and DNA strand breaks. These results suggest that persistent DNA damage in some lung adenocarcinoma cells may be caused by superoxide resulting from mutant K-ras activity, and that OGG1 is important for prevention of this damage. JF - Free radical biology & medicine AU - Romanowska, Malgorzata AU - Maciag, Anna AU - Smith, Andrew L AU - Fields, Janet R AU - Fornwald, Laura W AU - Kikawa, Keith D AU - Kasprzak, Kazimierz S AU - Anderson, Lucy M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538/206, Fort Detrick, Frederick, MD 21702, USA. Y1 - 2007/10/15/ PY - 2007 DA - 2007 Oct 15 SP - 1145 EP - 1155 VL - 43 IS - 8 SN - 0891-5849, 0891-5849 KW - Superoxides KW - 11062-77-4 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - DNA Glycosylases KW - EC 3.2.2.- KW - oxoguanine glycosylase 1, human KW - 8-oxodGTPase KW - EC 3.6.1.55 KW - ras Proteins KW - EC 3.6.5.2 KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - DNA Repair Enzymes -- metabolism KW - Humans KW - DNA Glycosylases -- metabolism KW - Superoxide Dismutase -- metabolism KW - Cell Line, Tumor KW - ras Proteins -- metabolism KW - Neoplasm Invasiveness -- genetics KW - Phosphoric Monoester Hydrolases -- metabolism KW - Adenocarcinoma -- physiopathology KW - Superoxides -- metabolism KW - Genes, ras -- genetics KW - DNA Damage KW - Lung Neoplasms -- genetics KW - Adenocarcinoma -- genetics KW - Lung Neoplasms -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68273477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=DNA+damage%2C+superoxide%2C+and+mutant+K-ras+in+human+lung+adenocarcinoma+cells.&rft.au=Romanowska%2C+Malgorzata%3BMaciag%2C+Anna%3BSmith%2C+Andrew+L%3BFields%2C+Janet+R%3BFornwald%2C+Laura+W%3BKikawa%2C+Keith+D%3BKasprzak%2C+Kazimierz+S%3BAnderson%2C+Lucy+M&rft.aulast=Romanowska&rft.aufirst=Malgorzata&rft.date=2007-10-15&rft.volume=43&rft.issue=8&rft.spage=1145&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carbaryl exposure and incident cancer in the Agricultural Health Study. AN - 68202203; 17534892 AB - Carbaryl is a carbamate insecticide with a broad spectrum of uses in agricultural, commercial and household settings. It has previously been linked with non-Hodgkin lymphoma (NHL) but studies of cancer risk in humans are limited. We examined occupational carbaryl use and risk of all cancers in the Agricultural Health Study, a prospective study of a cohort of pesticide applicators in North Carolina and Iowa. This analysis included 21,416 subjects (1,291 cases) enrolled from 1993-1997 and followed for cancer incidence through 2003. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Carbaryl was not associated with cancer risk overall. Relative to subjects who never used carbaryl, melanoma risk was elevated with >175 lifetime exposure-days (RR = 4.11; 95%CI, 1.33-12.75; p-trend = 0.07), >10 years of use (RR = 3.19; 95%CI, 1.28-7.92; p-trend = 0.04), or >or=10 days of use per year (RR = 5.50; 95%CI, 2.19-13.84; p-trend < 0.001). Risk remained after adjusting for sunlight exposure. Although not significant, there appeared to be a trend of decreasing prostate cancer risk with increasing level of exposure. A small increase in NHL risk was observed using some, but not all, exposure measures. No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution. (c) 2007 Wiley-Liss, Inc. JF - International journal of cancer AU - Mahajan, Rajeev AU - Blair, Aaron AU - Coble, Joseph AU - Lynch, Charles F AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USA. Y1 - 2007/10/15/ PY - 2007 DA - 2007 Oct 15 SP - 1799 EP - 1805 VL - 121 IS - 8 SN - 0020-7136, 0020-7136 KW - Insecticides KW - 0 KW - Carbaryl KW - R890C8J3N1 KW - Index Medicus KW - Odds Ratio KW - Prostatic Neoplasms -- epidemiology KW - Humans KW - Aged KW - Poisson Distribution KW - North Carolina -- epidemiology KW - Melanoma -- epidemiology KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Prospective Studies KW - Adult KW - Confounding Factors (Epidemiology) KW - Skin Neoplasms -- epidemiology KW - Incidence KW - Middle Aged KW - Female KW - Iowa -- epidemiology KW - Male KW - Insecticides -- toxicity KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Carbaryl -- toxicity KW - Occupational Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68202203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Carbaryl+exposure+and+incident+cancer+in+the+Agricultural+Health+Study.&rft.au=Mahajan%2C+Rajeev%3BBlair%2C+Aaron%3BCoble%2C+Joseph%3BLynch%2C+Charles+F%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Mahajan&rft.aufirst=Rajeev&rft.date=2007-10-15&rft.volume=121&rft.issue=8&rft.spage=1799&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Genomic Decoding of Human Liver Cancer. T2 - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AN - 40672710; 4748182 JF - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AU - Thorgeirsson, Snorri S Y1 - 2007/10/14/ PY - 2007 DA - 2007 Oct 14 KW - Liver cancer KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.atitle=Genomic+Decoding+of+Human+Liver+Cancer.&rft.au=Thorgeirsson%2C+Snorri+S&rft.aulast=Thorgeirsson&rft.aufirst=Snorri&rft.date=2007-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - https://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=8 73&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diagnostic and Prognostic Signatures of Liver Cancer. T2 - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AN - 40672095; 4748177 JF - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AU - Wang, Xin Wei Y1 - 2007/10/14/ PY - 2007 DA - 2007 Oct 14 KW - Liver cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40672095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.atitle=Diagnostic+and+Prognostic+Signatures+of+Liver+Cancer.&rft.au=Wang%2C+Xin+Wei&rft.aulast=Wang&rft.aufirst=Xin&rft.date=2007-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - https://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=8 73&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Causes and Consequences of Chromosomal Aneuploidy in Colon Cancer. T2 - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AN - 40671969; 4748173 JF - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AU - Ried, Thomas Y1 - 2007/10/14/ PY - 2007 DA - 2007 Oct 14 KW - Colon cancer KW - Aneuploidy KW - Chromosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.atitle=Causes+and+Consequences+of+Chromosomal+Aneuploidy+in+Colon+Cancer.&rft.au=Ried%2C+Thomas&rft.aulast=Ried&rft.aufirst=Thomas&rft.date=2007-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - https://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=8 73&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammation and Cancer: Interactions of the MicroRNA, p53 and Cytokine Pathways. T2 - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AN - 40671875; 4748153 JF - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AU - Harris, Curtis C Y1 - 2007/10/14/ PY - 2007 DA - 2007 Oct 14 KW - Cancer KW - Cytokines KW - MiRNA KW - P53 protein KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40671875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.atitle=Inflammation+and+Cancer%3A+Interactions+of+the+MicroRNA%2C+p53+and+Cytokine+Pathways.&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2007-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - https://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=8 73&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Unique Inflammatory Gene Signature Associated with Reduced Survival in Esophageal Cancer. T2 - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AN - 40670947; 4748161 JF - 2007 Conference on Frontiers in Gastrointestinal Cancer: Molecular Genetics, Inflammation, Early Detection and Therapy (T2) AU - Nguyen, Giang Huong Y1 - 2007/10/14/ PY - 2007 DA - 2007 Oct 14 KW - Cancer KW - Survival KW - Inflammation KW - Esophagus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40670947?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.atitle=A+Unique+Inflammatory+Gene+Signature+Associated+with+Reduced+Survival+in+Esophageal+Cancer.&rft.au=Nguyen%2C+Giang+Huong&rft.aulast=Nguyen&rft.aufirst=Giang&rft.date=2007-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Frontiers+in+Gastrointestinal+Cancer%3A+Molecular+Genetics%2C+Inflammation%2C+Early+Detection+and+Therapy+%28T2%29&rft.issn=&rft_id=info:doi/ L2 - https://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=8 73&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - 18F-Choline PET/CT in Early Re-Staging of Prostate Cancer Patients at High-Risk for Recurrence T2 - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AN - 40701980; 4753908 JF - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AU - Cimitan, M AU - Canzonieri, V AU - Bortolus, R AU - Morassut, S AU - Baresic, T AU - Bagatin, E AU - Borsatti, E AU - Garbeglio, A Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 KW - Prostate cancer KW - Risk groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40701980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.atitle=18F-Choline+PET%2FCT+in+Early+Re-Staging+of+Prostate+Cancer+Patients+at+High-Risk+for+Recurrence&rft.au=Cimitan%2C+M%3BCanzonieri%2C+V%3BBortolus%2C+R%3BMorassut%2C+S%3BBaresic%2C+T%3BBagatin%2C+E%3BBorsatti%2C+E%3BGarbeglio%2C+A&rft.aulast=Cimitan&rft.aufirst=M&rft.date=2007-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm07.eanm.org/abstracts/abstract_search.php?navId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Possible use of FDG PET/CT as a Tool to Study Patients with Human Immunodeficiency Virus Infection and Related Tumors T2 - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AN - 40699939; 4753745 JF - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AU - Cimitan, M AU - Martellotta, F AU - Borsatti, E AU - Spina, M AU - Baresic, T AU - Decuzzi, M AU - Ruffo, R AU - Tirelli, U Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 KW - Infection KW - Tumors KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.atitle=The+Possible+use+of+FDG+PET%2FCT+as+a+Tool+to+Study+Patients+with+Human+Immunodeficiency+Virus+Infection+and+Related+Tumors&rft.au=Cimitan%2C+M%3BMartellotta%2C+F%3BBorsatti%2C+E%3BSpina%2C+M%3BBaresic%2C+T%3BDecuzzi%2C+M%3BRuffo%2C+R%3BTirelli%2C+U&rft.aulast=Cimitan&rft.aufirst=M&rft.date=2007-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm07.eanm.org/abstracts/abstract_search.php?navId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Y-90 Zevalin (anti-CD20) Radioimmunotherapy for Adults with Relapsed/Refractory Hodgkin's Disease T2 - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AN - 40699343; 4753537 JF - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AU - Lastoria, S AU - Aloj, L AU - Caraco, C AU - Tommaselli, A AU - Frigeri, F AU - Pinto, A AU - De Martinis, F AU - Casale, M Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 KW - Radioisotopes KW - Dosimetry KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.atitle=Y-90+Zevalin+%28anti-CD20%29+Radioimmunotherapy+for+Adults+with+Relapsed%2FRefractory+Hodgkin%27s+Disease&rft.au=Lastoria%2C+S%3BAloj%2C+L%3BCaraco%2C+C%3BTommaselli%2C+A%3BFrigeri%2C+F%3BPinto%2C+A%3BDe+Martinis%2C+F%3BCasale%2C+M&rft.aulast=Lastoria&rft.aufirst=S&rft.date=2007-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm07.eanm.org/abstracts/abstract_search.php?navId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Significance of Simultaneous Coregestration of Bone and I-131 Scanning in Evaluation of Metastatic Differentiated Thyroid Carcinoma Patients T2 - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AN - 40698900; 4753452 JF - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AU - Kotb, M H AU - Omar, W AU - Elbedwihy, M AU - El-Haj, S AU - Mustafa, H Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 KW - Bone KW - Thyroid KW - Scanning KW - Thyroid carcinoma KW - Metastases KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.atitle=Clinical+Significance+of+Simultaneous+Coregestration+of+Bone+and+I-131+Scanning+in+Evaluation+of+Metastatic+Differentiated+Thyroid+Carcinoma+Patients&rft.au=Kotb%2C+M+H%3BOmar%2C+W%3BElbedwihy%2C+M%3BEl-Haj%2C+S%3BMustafa%2C+H&rft.aulast=Kotb&rft.aufirst=M&rft.date=2007-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm07.eanm.org/abstracts/abstract_search.php?navId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of 18F-Fluoroethyl-L-Tyrosine PET/CT in the Surveillance of Patients with Previously Treated Gliomas T2 - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AN - 40697672; 4753838 JF - 20th Annual Congress of the European Association of Nuclear Medicine (EANM 2007) AU - Cimitan, M AU - Zanotti, B AU - Tuniz, F AU - Bagatin, E AU - Baresic, T AU - Borsatti, E AU - Gobitti, C AU - Trovo, M G AU - Skrap, M Y1 - 2007/10/13/ PY - 2007 DA - 2007 Oct 13 KW - Glioma KW - Brain tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40697672?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.atitle=Contribution+of+18F-Fluoroethyl-L-Tyrosine+PET%2FCT+in+the+Surveillance+of+Patients+with+Previously+Treated+Gliomas&rft.au=Cimitan%2C+M%3BZanotti%2C+B%3BTuniz%2C+F%3BBagatin%2C+E%3BBaresic%2C+T%3BBorsatti%2C+E%3BGobitti%2C+C%3BTrovo%2C+M+G%3BSkrap%2C+M&rft.aulast=Cimitan&rft.aufirst=M&rft.date=2007-10-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm07.eanm.org/abstracts/abstract_search.php?navId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. AN - 68353724; 17850978 AB - Valproic acid (VPA), a widely prescribed drug for seizures and bipolar disorder, has been shown to be an inhibitor of histone deacetylase (HDAC). Our previous study has demonstrated that VPA pretreatment reduces lipopolysaccharide (LPS)-induced dopaminergic (DA) neurotoxicity through the inhibition of microglia over-activation. The aim of this study was to determine the mechanism underlying VPA-induced attenuation of microglia over-activation using rodent primary neuron/glia or enriched glia cultures. Other histone deacetylase inhibitors (HDACIs) were compared with VPA for their effects on microglial activity. We found that VPA induced apoptosis of microglia cells in a time- and concentration-dependent manner. VPA-treated microglial cells showed typical apoptotic hallmarks including phosphatidylserine externalization, chromatin condensation and DNA fragmentation. Further studies revealed that trichostatin A (TSA) and sodium butyrate (SB), two structurally dissimilar HDACIs, also induced microglial apoptosis. The apoptosis of microglia was accompanied by the disruption of mitochondrial membrane potential and the enhancement of acetylation levels of the histone H3 protein. Moreover, pretreatment with SB or TSA caused a robust decrease in LPS-induced pro-inflammatory responses and protected DA neurons from damage in mesencephalic neuron-glia cultures. Taken together, our results shed light on a novel mechanism whereby HDACIs induce neuroprotection and underscore the potential utility of HDACIs in preventing inflammation-related neurodegenerative disorders such as Parkinson's disease. JF - Neuroscience AU - Chen, P S AU - Wang, C-C AU - Bortner, C D AU - Peng, G-S AU - Wu, X AU - Pang, H AU - Lu, R-B AU - Gean, P-W AU - Chuang, D-M AU - Hong, J-S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2007/10/12/ PY - 2007 DA - 2007 Oct 12 SP - 203 EP - 212 VL - 149 IS - 1 SN - 0306-4522, 0306-4522 KW - Enzyme Inhibitors KW - 0 KW - Lipopolysaccharides KW - Nitrites KW - Tumor Necrosis Factor-alpha KW - Valproic Acid KW - 614OI1Z5WI KW - Histone Acetyltransferases KW - EC 2.3.1.48 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Brain -- cytology KW - Dose-Response Relationship, Drug KW - Nitrites -- metabolism KW - Pregnancy KW - In Situ Nick-End Labeling -- methods KW - Rats KW - Animals, Newborn KW - Rats, Inbred F344 KW - Membrane Potential, Mitochondrial -- drug effects KW - Cells, Cultured KW - Histone Acetyltransferases -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Histone Acetyltransferases -- antagonists & inhibitors KW - Cell Cycle -- drug effects KW - Female KW - Valproic Acid -- pharmacology KW - Neurons -- drug effects KW - Apoptosis -- drug effects KW - Lipopolysaccharides -- toxicity KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Neuroglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68353724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Valproic+acid+and+other+histone+deacetylase+inhibitors+induce+microglial+apoptosis+and+attenuate+lipopolysaccharide-induced+dopaminergic+neurotoxicity.&rft.au=Chen%2C+P+S%3BWang%2C+C-C%3BBortner%2C+C+D%3BPeng%2C+G-S%3BWu%2C+X%3BPang%2C+H%3BLu%2C+R-B%3BGean%2C+P-W%3BChuang%2C+D-M%3BHong%2C+J-S&rft.aulast=Chen&rft.aufirst=P&rft.date=2007-10-12&rft.volume=149&rft.issue=1&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2007-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurochem. 2003 Oct;87(2):407-16 [14511118] J Neurosci. 2003 Oct 8;23(27):9162-70 [14534250] J Neurosci. 2003 Oct 15;23(28):9418-27 [14561870] J Neurosci. 2006 Jul 12;26(28):7502-12 [16837598] Nat Rev Drug Discov. 2006 Sep;5(9):769-84 [16955068] Nat Med. 2006 Sep;12(9):1056-64 [16951685] Mol Psychiatry. 2006 Dec;11(12):1116-25 [16969367] Nat Rev Neurosci. 2007 Jan;8(1):57-69 [17180163] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Glia. 2001 Jan;33(1):87-95 [11169794] J Immunol. 2001 Jun 15;166(12):7290-9 [11390479] Clin Biochem. 2001 May;34(3):211-8 [11408019] J Biol Chem. 2001 Sep 28;276(39):36734-41 [11473107] J Immunol. 2001 Nov 1;167(9):5004-10 [11673508] J Immunol. 2002 Jul 15;169(2):702-13 [12097372] Brain Res Dev Brain Res. 2002 Dec 15;139(2):337-42 [12480151] FEBS Lett. 2003 May 8;542(1-3):74-8 [12729901] Glia. 2003 Sep;43(3):231-42 [12898702] Br J Pharmacol. 2004 Mar;141(5):874-80 [14744800] BMC Cancer. 2003 Nov 9;3:30 [14606959] Hum Mol Genet. 2004 Jun 1;13(11):1183-92 [15102712] J Neuroimmunol. 2004 Jun;151(1-2):85-93 [15145607] J Neurochem. 2004 Jun;89(6):1358-67 [15189338] Pharmacogenomics J. 2004;4(5):336-44 [15289798] J Biol Chem. 2005 Jan 7;280(1):556-63 [15494404] Neuromolecular Med. 2004;5(3):235-41 [15626823] Nat Immunol. 2005 Feb;6(2):211-8 [15640802] Psychiatry Res. 2004 Dec 30;129(3):267-72 [15661320] Neurosci Lett. 2005 Feb 28;375(2):91-6 [15670648] Drug Discov Today. 2005 Feb 1;10(3):197-204 [15708534] Brain Res Mol Brain Res. 2005 Mar 24;134(1):162-9 [15790540] Science. 2005 May 27;308(5726):1314-8 [15831717] Cytometry A. 2005 Jul;66(1):52-61 [15915507] J Neuroimmunol. 2005 Jul;164(1-2):10-21 [15885809] J Neuroimmunol. 2005 Nov;168(1-2):56-64 [16091294] Am J Psychiatry. 2006 Feb;163(2):272-5 [16449481] Neurobiol Dis. 2006 Apr;22(1):40-9 [16289867] J Pharmacol Exp Ther. 2006 May;317(2):546-52 [16497787] Neurology. 2006 Jun 13;66(11):1638-43 [16769933] Neuroscience. 2006 Jul 21;140(4):1149-56 [16600518] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structure-function analysis of the WIP role in T cell receptor-stimulated NFAT activation: evidence that WIP-WASP dissociation is not required and that the WIP NH2 terminus is inhibitory. AN - 68353629; 17711847 AB - WASP and its binding partner WIP play important roles in T cells both in actin polymerization and in interleukin-2 transcription. Aberrations thereof contribute to the pathology of Wiskott-Aldrich syndrome (WAS). To directly evaluate the cooperativity of WIP and WASP in interleukin-2 transcription, we investigated how the WIP-WASP complex regulates NF-AT-mediated gene transcription. We developed an improved model system for analysis, using WIP and WASP cotransfection into Jurkat cells, in which strong induction of NFAT reporter activation is observed with anti-T cell receptor (TCR) antibody without the phorbol 12-myristate 13-acetate usually used previously. Using this system, our findings contradict a prevailing conceptual model of TCR-induced WIP-WASP dissociation by showing in three ways that the WIP-WASP complex mediates TCR-induced NFAT activation without dissociation. First, phosphorylation of WIP Ser(488) does not cause dissociation of the WIP-WASP complex. Second, WIP-WASP complexes do not dissociate demonstrably after TCR stimulation. Third, a fusion protein of WIP to WASP efficiently mediates NFAT activation. Next, our studies clarify that WIP stabilization of WASP explains otherwise unexpected results in TCR-induced NFAT activation. Finally, we find that the NH(2) terminus of WIP is a highly inhibitory region for TCR-mediated transcriptional activation in which at least two elements contribute: the NH(2)-terminal polyproline and the NH(2)-terminal actin-binding WH2 domain. This suggests that WIP, like WASP, is subject to autoinhibition. Our data indicate that the WIP-WASP complex plays an important role in WASP stabilization and NFAT activation. JF - The Journal of biological chemistry AU - Dong, Xiaoyun AU - Patino-Lopez, Genaro AU - Candotti, Fabio AU - Shaw, Stephen AD - Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892-1360, USA. Y1 - 2007/10/12/ PY - 2007 DA - 2007 Oct 12 SP - 30303 EP - 30310 VL - 282 IS - 41 SN - 0021-9258, 0021-9258 KW - Actins KW - 0 KW - Antigens, CD3 KW - Cytoskeletal Proteins KW - Interleukin-2 KW - Intracellular Signaling Peptides and Proteins KW - NFATC Transcription Factors KW - Receptors, Antigen, T-Cell KW - WAS protein, human KW - WIPF1 protein, human KW - Wiskott-Aldrich Syndrome Protein KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Interleukin-2 -- metabolism KW - Antigens, CD3 -- biosynthesis KW - Tetradecanoylphorbol Acetate -- chemistry KW - Kinetics KW - Humans KW - Receptors, Antigen, T-Cell -- metabolism KW - Jurkat Cells KW - Wiskott-Aldrich Syndrome -- metabolism KW - Protein Structure, Tertiary KW - Models, Biological KW - Actins -- chemistry KW - Structure-Activity Relationship KW - NFATC Transcription Factors -- chemistry KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Transcription, Genetic KW - Wiskott-Aldrich Syndrome Protein -- metabolism KW - Cytoskeletal Proteins -- metabolism KW - NFATC Transcription Factors -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68353629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Structure-function+analysis+of+the+WIP+role+in+T+cell+receptor-stimulated+NFAT+activation%3A+evidence+that+WIP-WASP+dissociation+is+not+required+and+that+the+WIP+NH2+terminus+is+inhibitory.&rft.au=Dong%2C+Xiaoyun%3BPatino-Lopez%2C+Genaro%3BCandotti%2C+Fabio%3BShaw%2C+Stephen&rft.aulast=Dong&rft.aufirst=Xiaoyun&rft.date=2007-10-12&rft.volume=282&rft.issue=41&rft.spage=30303&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2001 Jun 15;276(24):21450-7 [11283014] Nat Cell Biol. 2000 Jul;2(7):441-8 [10878810] Eur J Immunol. 2000 Dec;30(12):3645-54 [11169407] J Immunol. 2001 Oct 15;167(8):4701-9 [11591801] Hum Gene Ther. 2002 Jun 10;13(9):1039-46 [12067437] Cell. 2002 Nov 15;111(4):565-76 [12437929] Mol Cell. 2002 Dec;10(6):1269-81 [12504004] Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):427-36 [14612666] J Exp Med. 2004 Feb 2;199(3):357-68 [14757742] J Immunol. 2004 Aug 1;173(3):1658-62 [15265894] Cell. 1994 Aug 26;78(4):635-44 [8069912] Nat Genet. 1995 Apr;9(4):414-7 [7795648] Protein Sci. 1995 Dec;4(12):2455-68 [8580836] Cell. 1996 Mar 8;84(5):723-34 [8625410] J Clin Invest. 1996 Jun 1;97(11):2627-34 [8647957] Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14671-6 [9405671] Cell Mol Life Sci. 1998 Oct;54(10):1145-53 [9817992] J Immunol. 1999 Apr 15;162(8):5019-24 [10202051] J Immunol. 2005 Mar 1;174(5):2602-11 [15728466] FEBS J. 2005 Dec;272(23):6131-44 [16302976] J Allergy Clin Immunol. 2005 Dec;116(6):1364-71 [16337472] Biochem Biophys Res Commun. 2006 Feb 10;340(2):709-17 [16378591] Biochem Biophys Res Commun. 2006 Apr 7;342(2):529-36 [16488394] J Biol Chem. 2006 Apr 14;281(15):10589-97 [16403731] J Immunol. 2006 Nov 15;177(10):7451-61 [17082665] Curr Biol. 2006 Dec 5;16(23):2337-44 [17141616] Biochem Biophys Res Commun. 2007 Feb 23;353(4):875-81 [17207458] Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):926-31 [17213309] Int Immunol. 2007 Feb;19(2):185-92 [17205972] J Immunol. 2007 Mar 1;178(5):2987-95 [17312144] Biochem Biophys Res Commun. 2007 May 25;357(1):289-94 [17418095] J Immunol. 2000 Mar 15;164(6):2866-70 [10706671] Nature. 2000 Mar 9;404(6774):151-8 [10724160] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - SLPI Disrupts Plasminogen- Dependent Proteolysis in Inflammation and Tumor Progression. T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40699404; 4756032 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - Greenwell-Wild, T AU - Wen, J AU - Nikitakis, N AU - Moutsopoulos, N AU - Jin, W AU - Ma, G. AU - Warburton, G AU - Chaisuparat, R AU - Wahl, S M Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Tumors KW - Proteolysis KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40699404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=SLPI+Disrupts+Plasminogen-+Dependent+Proteolysis+in+Inflammation+and+Tumor+Progression.&rft.au=Greenwell-Wild%2C+T%3BWen%2C+J%3BNikitakis%2C+N%3BMoutsopoulos%2C+N%3BJin%2C+W%3BMa%2C+G.%3BWarburton%2C+G%3BChaisuparat%2C+R%3BWahl%2C+S+M&rft.aulast=Greenwell-Wild&rft.aufirst=T&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Increased TGF-b in HIV-Infected Lymphoid Tissues May Influence Treg Accumulation to Blunt Immune Surveillance. T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40698990; 4756034 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - Moutsopoulos, N M AU - Wen, J AU - Orenstein, J AU - Wahl, S M Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Lymphoid tissue KW - Lymphocytes T KW - Transforming growth factor-b KW - Immunosurveillance KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=Increased+TGF-b+in+HIV-Infected+Lymphoid+Tissues+May+Influence+Treg+Accumulation+to+Blunt+Immune+Surveillance.&rft.au=Moutsopoulos%2C+N+M%3BWen%2C+J%3BOrenstein%2C+J%3BWahl%2C+S+M&rft.aulast=Moutsopoulos&rft.aufirst=N&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysregulated Expression of IL-17 Family Members Linked to Autoimmune-Like Inflammatory Lesions in the Absence of TGF-b1. T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40698929; 4756023 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - McCartney-Francis, N AU - Rekka, S AU - Jin, W AU - Wahl, S M Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Lesions KW - Interleukin 17 KW - Inflammation KW - Transforming growth factor-b1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40698929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=Dysregulated+Expression+of+IL-17+Family+Members+Linked+to+Autoimmune-Like+Inflammatory+Lesions+in+the+Absence+of+TGF-b1.&rft.au=McCartney-Francis%2C+N%3BRekka%2C+S%3BJin%2C+W%3BWahl%2C+S+M&rft.aulast=McCartney-Francis&rft.aufirst=N&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - M. avium Manipulation of Host Factors Supports their Persistence in Macrophages. T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40697661; 4756095 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - Vazquez, N AU - Wild, T AU - Rekka, S AU - Orenstein, J AU - Wahl, S M Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Macrophages KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40697661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=M.+avium+Manipulation+of+Host+Factors+Supports+their+Persistence+in+Macrophages.&rft.au=Vazquez%2C+N%3BWild%2C+T%3BRekka%2C+S%3BOrenstein%2C+J%3BWahl%2C+S+M&rft.aulast=Vazquez&rft.aufirst=N&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lactoferrin: A New Alarmin? T2 - 40th Annual Meeting of the Society for Leukocyte Biology AN - 40697286; 4755967 JF - 40th Annual Meeting of the Society for Leukocyte Biology AU - de la Rosa, G AU - Yang, D AU - Oppenheim, J J Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Lactoferrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40697286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.atitle=Lactoferrin%3A+A+New+Alarmin%3F&rft.au=de+la+Rosa%2C+G%3BYang%2C+D%3BOppenheim%2C+J+J&rft.aulast=de+la+Rosa&rft.aufirst=G&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=40th+Annual+Meeting+of+the+Society+for+Leukocyte+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.leukocytebiology.org/2007meeting/pdf/FINAL_Official%202007% 20SLB%20Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prevalence of Post-Traumatic Stress Disorder Five Years after Giant Fire of "Mesa Redonda", Lima, Peru. T2 - 6th World Congress on Stress AN - 39476400; 4674991 JF - 6th World Congress on Stress AU - Vasquez, Freddy AU - Vite, Vilma Y1 - 2007/10/11/ PY - 2007 DA - 2007 Oct 11 KW - Argentina, Buenos Aire, Lima KW - Peru KW - Stress KW - Fires KW - Post-traumatic stress disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39476400?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=6th+World+Congress+on+Stress&rft.atitle=Prevalence+of+Post-Traumatic+Stress+Disorder+Five+Years+after+Giant+Fire+of+%22Mesa+Redonda%22%2C+Lima%2C+Peru.&rft.au=Vasquez%2C+Freddy%3BVite%2C+Vilma&rft.aulast=Vasquez&rft.aufirst=Freddy&rft.date=2007-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=6th+World+Congress+on+Stress&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/stress2007/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cryo-electron microscopy and three-dimensional reconstructions of hepatitis C virus particles AN - 20347101; 7630768 AB - The structural details of hepatitis C virus (HCV) have been elusive because of the lack of a robust tissue culture system for producing an adequate amount of virions from infectious sources for in-depth three-dimensional (3D) structural analysis. Using both negative-stain and cryo-electron microscopy (cryoEM), we show that HCV virions isolated from cell culture have a rather uniform size of 500 A in diameter and that recombinantly expressed HCV-like particles (HCV-LPs) have similar morphologic, biophysical and antigenic features in spite of the varying sizes of the particles. 3D reconstructions were obtained from HCV-LPs with the same size as the HCV virions in the presence and absence of monoclonal antibodies bound to the E1 glycoprotein. The 3D reconstruction of HCV-LP reveals a multilayered architecture, with smooth outer-layer densities arranged in a 'fishbone' configuration. Reconstruction of the particles in complex with anti-E1 antibodies shows that sites of the E1 epitope are exposed and surround the 5-, 3- and 2-fold axes. The binding pattern of the anti-E1 antibody and the fitting of the structure of the dengue virus E glycoprotein into our 3D reconstructions further suggest that the HCV-LP E1 and E2 proteins form a tetramer (or dimer of heterodimers) that corresponds morphologically and functionally to the flavivirus E homodimer. This first 3D structural analysis of HCV particles offers important insights into the elusive mechanisms of HCV assembly and maturation. JF - Virology AU - Yu, X AU - Qiao, M AU - Atanasov, I AU - Hu, Z AU - Kato, T AU - Liang, T J AU - Zhou, Z H AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, jliang@nih.gov Y1 - 2007/10/10/ PY - 2007 DA - 2007 Oct 10 SP - 126 EP - 134 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 367 IS - 1 SN - 0042-6822, 0042-6822 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Virions KW - Dengue virus KW - Monoclonal antibodies KW - E2 protein KW - Cell culture KW - ^AE2 protein KW - Tissue culture KW - Flavivirus KW - Hepatitis C virus KW - Glycoproteins KW - Epitopes KW - W 30960:Bioinformatics & Computer Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20347101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Cryo-electron+microscopy+and+three-dimensional+reconstructions+of+hepatitis+C+virus+particles&rft.au=Yu%2C+X%3BQiao%2C+M%3BAtanasov%2C+I%3BHu%2C+Z%3BKato%2C+T%3BLiang%2C+T+J%3BZhou%2C+Z+H&rft.aulast=Yu&rft.aufirst=X&rft.date=2007-10-10&rft.volume=367&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/10.1016%2Fj.virol.2007.05.038 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hepatitis C virus; Flavivirus; Dengue virus; Virions; Glycoproteins; Monoclonal antibodies; Tissue culture; Epitopes; Cell culture; E2 protein; ^AE2 protein DO - http://dx.doi.org/10.1016/j.virol.2007.05.038 ER - TY - JOUR T1 - Dysadherin: a new player in cancer progression. AN - 68199797; 17442482 AB - Dysadherin is a cancer-associated cell membrane glycoprotein that promotes experimental cancer metastasis. Here we review recent work that has provided insights into possible mechanisms of action of this newly recognized player in the cancer progression process. Dysadherin modulates cell phenotype in a number of ways, including down-regulation of E-cadherin-mediated cell adhesion, and up-regulation of chemokine production. In this way, expression of dysadherin in a tumor can influence both the tumor cell itself and the stromal compartment, so as to create conditions that are more permissive for metastatic spread. Dysadherin expression is also an independent prognostic indicator of metastasis and survival for many different types of human cancer. Thus, dysadherin may represent a new molecular target for the visualization, prevention or treatment of advanced cancer. JF - Cancer letters AU - Nam, Jeong-Seok AU - Hirohashi, Setsuo AU - Wakefield, Lalage M AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. namje@mail.nih.gov Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 SP - 161 EP - 169 VL - 255 IS - 2 SN - 0304-3835, 0304-3835 KW - FXYD5 protein, human KW - 0 KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - Index Medicus KW - Humans KW - Prognosis KW - Molecular Sequence Data KW - Disease Progression KW - Amino Acid Sequence KW - Neoplasm Proteins -- drug effects KW - Membrane Glycoproteins -- drug effects KW - Neoplasms -- pathology KW - Membrane Glycoproteins -- analysis KW - Neoplasm Proteins -- analysis KW - Neoplasm Proteins -- metabolism KW - Neoplasms -- metabolism KW - Membrane Glycoproteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68199797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Dysadherin%3A+a+new+player+in+cancer+progression.&rft.au=Nam%2C+Jeong-Seok%3BHirohashi%2C+Setsuo%3BWakefield%2C+Lalage+M&rft.aulast=Nam&rft.aufirst=Jeong-Seok&rft.date=2007-10-08&rft.volume=255&rft.issue=2&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pathol Oncol Res. 2004;10(4):212-8 [15619642] Appl Immunohistochem Mol Morphol. 2004 Dec;12(4):323-8 [15536331] Cancer. 2005 Apr 15;103(8):1693-700 [15751018] J Thorac Cardiovasc Surg. 2005 Sep;130(3):740-5 [16153922] J Biol Chem. 2005 Nov 11;280(45):37717-24 [16148001] Br J Cancer. 2005 Dec 12;93(12):1382-7 [16333245] Am J Physiol Renal Physiol. 2006 Feb;290(2):F241-50 [16403837] Nature. 2006 Jan 19;439(7074):353-7 [16273092] Am J Surg Pathol. 2006 Feb;30(2):185-93 [16434892] Cancer Cell. 2006 Apr;9(4):287-300 [16616334] Genome Biol. 2006;7(3):R19 [16542501] Virchows Arch. 2006 Jun;448(6):763-7 [16570180] Cancer Res. 2006 Jul 15;66(14):7176-84 [16849564] J Natl Cancer Inst. 2006 Sep 6;98(17):1193-203 [16954472] Cancer Res. 2006 Dec 1;66(23):11089-93 [17145848] Blood. 2000 Jul 1;96(1):34-40 [10891427] Clin Cancer Res. 2000 Aug;6(8):3282-9 [10955814] Cancer. 2001 Sep 1;92(5):1085-91 [11571719] J Biol Chem. 2001 Nov 9;276(45):42050-6 [11562372] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):365-70 [11756660] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Sci STKE. 2003 Jan 21;2003(166):RE1 [12538882] J Clin Oncol. 2003 Feb 15;21(4):659-67 [12586803] Int J Oncol. 2003 Apr;22(4):773-8 [12632067] Glycobiology. 2003 Jul;13(7):521-7 [12672699] Cancer Sci. 2003 Jul;94(7):575-81 [12841864] J Clin Endocrinol Metab. 2003 Sep;88(9):4407-12 [12970317] Cancer Biol Ther. 2003 Jul-Aug;2(4):406-15 [14508115] Clin Cancer Res. 2004 Apr 15;10(8):2818-23 [15102690] Cancer Sci. 2004 Jul;95(7):575-82 [15245593] Semin Cancer Biol. 2004 Jun;14(3):149-54 [15246049] Cancer Res. 2004 Sep 15;64(18):6503-10 [15374961] Oncology. 2004;67(1):73-80 [15459499] Cancer Res. 2004 Oct 1;64(19):6989-95 [15466191] Mol Cell Biol. 1997 Mar;17(3):1503-12 [9032278] Int J Cancer. 1997 Apr 10;71(2):257-66 [9139852] J Biol Chem. 1998 Jun 12;273(24):15249-56 [9614140] Am J Pathol. 1998 Aug;153(2):333-9 [9708792] Lancet. 2005 Feb 19-25;365(9460):671-9 [15721472] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial behavioral syndromes and DSM-IV drug use disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions AN - 57234062; 200804150 AB - Background Antisocial behavioral syndromes, including antisocial personality disorder (ASPD), syndromal adult antisocial behavior (AABS) without conduct disorder (CD) before age 15, and CD without progression to ASPD ('CD only') are highly comorbid with drug use disorders (DUDs). Among patients in DUD treatment, antisocial syndromes are associated with greater severity and poorer outcomes. Comparative data concerning associations of antisocial syndromes with clinical characteristics of DUDs among general population adults have not previously been available. This study describes associations of antisocial syndromes with clinical characteristics of lifetime Diagnostic and Statistical Manual-Version IV DUDs in the general U.S. adult population. Methods This report is based on the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (n=43,093, response rate=81%). Respondents (n=4068) with lifetime DUDs were classified according to whether they met criteria for ASPD, AABS, 'CD only,' or no antisocial syndrome. Associations of antisocial syndromes with clinical characteristics of DUDs were examined using logistic regression. Results Antisocial syndromes were significantly associated with the phenomenology of DUDs, particularly ASPD with the most severe clinical presentations. Associations with AABS were similar to those with ASPD; those with 'CD only' were weak, inconsistent, and not statistically significant. Patterns of associations differed little between men and women. Conclusions Both ASPD and AABS, but not 'CD only,' appear to identify greater clinical severity of DUDs among adults in the general U.S. population. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Goldstein, Rise B AU - Compton, Wilson M AU - Pulay, Attila J AU - Ruan, W June AU - Pickering, Roger P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 SP - 145 EP - 158 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 90 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Antisocial personality disorder KW - Conduct disorder KW - Drug use disorders KW - Conduct disorders KW - Antisocial behaviour KW - Drug abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57234062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Antisocial+behavioral+syndromes+and+DSM-IV+drug+use+disorders+in+the+United+States%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions&rft.au=Goldstein%2C+Rise+B%3BCompton%2C+Wilson+M%3BPulay%2C+Attila+J%3BRuan%2C+W+June%3BPickering%2C+Roger+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Goldstein&rft.aufirst=Rise&rft.date=2007-10-08&rft.volume=90&rft.issue=2-3&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.02.023 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Antisocial behaviour; Conduct disorders; Drug abuse DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.02.023 ER - TY - JOUR T1 - Changes in the prevalence of non-medical prescription drug use and drug use disorders in the United States: 1991-1992 and 2001-2002 AN - 57216110; 200803656 AB - Objective To examine changes in the prevalence of non-medical prescription drug use and DSM-IV non-medical prescription abuse and dependence in the United States between 1991-1992 and 2001-2002. Method Comparison of the prevalence of past-year non-medical prescription drug use and drug use disorders in the total sample and among lifetime non-medical users in two large national surveys conducted 10 years apart. Results From 1991-1992 to 2001-2002, the prevalence of DSM-IV non-medical prescription drug use increased by 53%, from 1.5% to 2.3% (p<0.001), and the prevalence of drug use disorders increased by 67% from 0.3% to 0.5% (p<0.001). The conditional prevalence of a disorder among users increased numerically from 19.9% to 23.6%, but this increase was not statistically significant (p=0.15). Conclusions There have been substantial increases in the prevalence of prescription drug non-medical use and prescription drug use disorders in the United States. Given the clinical utility of prescription drugs, urgent action is needed to find approaches that balance the need for access to these medications among those who need them, against their potential for abuse and dependence in subgroups of vulnerable individuals. [Copyright 2007 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Blanco, Carlos AU - Alderson, Donald AU - Ogburn, Elizabeth AU - Grant, Bridget F AU - Nunes, Edward V AU - Hatzenbuehler, Mark L AU - Hasin, Deborah S AD - Departments of Epidemiology and Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, United States Y1 - 2007/10/08/ PY - 2007 DA - 2007 Oct 08 SP - 252 EP - 260 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 90 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Prescription drug abuse KW - Epidemiology KW - Prevalence trends KW - NESARC KW - Prescriptions KW - Drug abuse KW - Prevalence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57216110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Changes+in+the+prevalence+of+non-medical+prescription+drug+use+and+drug+use+disorders+in+the+United+States%3A+1991-1992+and+2001-2002&rft.au=Blanco%2C+Carlos%3BAlderson%2C+Donald%3BOgburn%2C+Elizabeth%3BGrant%2C+Bridget+F%3BNunes%2C+Edward+V%3BHatzenbuehler%2C+Mark+L%3BHasin%2C+Deborah+S&rft.aulast=Blanco&rft.aufirst=Carlos&rft.date=2007-10-08&rft.volume=90&rft.issue=2-3&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2007.04.005 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-03-04 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Prescriptions; Drug abuse; Epidemiology; Prevalence DO - http://dx.doi.org/10.1016/j.drugalcdep.2007.04.005 ER - TY - CPAPER T1 - Preclinical Toxicology and Development of SR13668, a Novel New Candidate Cancer Chemopreventive Agent T2 - 44th Congress of the European Societies of Toxicology AN - 40689922; 4749156 JF - 44th Congress of the European Societies of Toxicology AU - Kapetanovic, Izet M AU - Jong, Ling AU - Green, Carol E AU - Shankar, Gita AU - Swezey, Robert AU - Bakke, James AU - Crowell, James A Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Cancer KW - Toxicology KW - Chemopreventive agents KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Congress+of+the+European+Societies+of+Toxicology&rft.atitle=Preclinical+Toxicology+and+Development+of+SR13668%2C+a+Novel+New+Candidate+Cancer+Chemopreventive+Agent&rft.au=Kapetanovic%2C+Izet+M%3BJong%2C+Ling%3BGreen%2C+Carol+E%3BShankar%2C+Gita%3BSwezey%2C+Robert%3BBakke%2C+James%3BCrowell%2C+James+A&rft.aulast=Kapetanovic&rft.aufirst=Izet&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Congress+of+the+European+Societies+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurotox2007.org/downloads/list-of-presentations.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Toxicokinetics of Resveratrol in Dogs T2 - 44th Congress of the European Societies of Toxicology AN - 40689853; 4749151 JF - 44th Congress of the European Societies of Toxicology AU - Crowell, James AU - McCormick, David AU - Cwik, Michael AU - Kapetanovic, Izet Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Resveratrol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40689853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Congress+of+the+European+Societies+of+Toxicology&rft.atitle=Toxicokinetics+of+Resveratrol+in+Dogs&rft.au=Crowell%2C+James%3BMcCormick%2C+David%3BCwik%2C+Michael%3BKapetanovic%2C+Izet&rft.aulast=Crowell&rft.aufirst=James&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Congress+of+the+European+Societies+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurotox2007.org/downloads/list-of-presentations.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics of Resveratrol in Monkeys T2 - 44th Congress of the European Societies of Toxicology AN - 40688098; 4749150 JF - 44th Congress of the European Societies of Toxicology AU - Crowell, James AU - McCormick, David AU - Cwik, Michael AU - Kapetanovic, Izet Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Pharmacokinetics KW - Resveratrol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40688098?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Congress+of+the+European+Societies+of+Toxicology&rft.atitle=Pharmacokinetics+of+Resveratrol+in+Monkeys&rft.au=Crowell%2C+James%3BMcCormick%2C+David%3BCwik%2C+Michael%3BKapetanovic%2C+Izet&rft.aulast=Crowell&rft.aufirst=James&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Congress+of+the+European+Societies+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.eurotox2007.org/downloads/list-of-presentations.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Macrophage Foam Cell Formation Mediated by Receptor-Independent Macropinocytosis of LDL T2 - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AN - 39721083; 4720552 JF - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AU - Kruth, H S AU - Buono, C AU - Waldo, S W AU - Li, Y. Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Macrophages KW - Lipoproteins (low density) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39721083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.atitle=Macrophage+Foam+Cell+Formation+Mediated+by+Receptor-Independent+Macropinocytosis+of+LDL&rft.au=Kruth%2C+H+S%3BBuono%2C+C%3BWaldo%2C+S+W%3BLi%2C+Y.&rft.aulast=Kruth&rft.aufirst=H&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/cad/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blieberry-Enriched Diet Protects Hearts from Ischemic Damage T2 - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AN - 39653026; 4720526 JF - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AU - Ismayil, A AU - Spangler, E AU - Shukitt-Hale, B AU - Joseph, J A AU - Ingram, D K AU - Talan, M I Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Diets KW - Ischemia KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39653026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.atitle=Blieberry-Enriched+Diet+Protects+Hearts+from+Ischemic+Damage&rft.au=Ismayil%2C+A%3BSpangler%2C+E%3BShukitt-Hale%2C+B%3BJoseph%2C+J+A%3BIngram%2C+D+K%3BTalan%2C+M+I&rft.aulast=Ismayil&rft.aufirst=A&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/cad/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synergistic Effect of Stem Cell Injection and Transmyocardial Laser Revascularization T2 - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AN - 39525216; 4720580 JF - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AU - Zhou, Y AU - Yu, Z. AU - Zhang, Z AU - Sidenko, S AU - Sachdev, V AU - Horvath, K A Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Lasers KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39525216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.atitle=Synergistic+Effect+of+Stem+Cell+Injection+and+Transmyocardial+Laser+Revascularization&rft.au=Zhou%2C+Y%3BYu%2C+Z.%3BZhang%2C+Z%3BSidenko%2C+S%3BSachdev%2C+V%3BHorvath%2C+K+A&rft.aulast=Zhou&rft.aufirst=Y&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/cad/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NHLBI Cardiovascular Cell Therapy Research Network T2 - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AN - 39525069; 4720565 JF - 7th International Congress on Coronary Artery Disease - from Prevention to intervention (ICCAD 2007) AU - Skarlatos, S I Y1 - 2007/10/07/ PY - 2007 DA - 2007 Oct 07 KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39525069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.atitle=NHLBI+Cardiovascular+Cell+Therapy+Research+Network&rft.au=Skarlatos%2C+S+I&rft.aulast=Skarlatos&rft.aufirst=S&rft.date=2007-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Congress+on+Coronary+Artery+Disease+-+from+Prevention+to+intervention+%28ICCAD+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/cad/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library. AN - 69086147; 17919322 AB - Amino acid sequence diversity is introduced into a phage-displayed peptide library by randomizing library oligonucleotide DNA. We recently evaluated the diversity of peptide libraries displayed on T7 lytic phage and M13 filamentous phage and showed that T7 phage can display a more diverse amino acid sequence repertoire due to differing processes of viral morphogenesis. In this study, we evaluated and compared the diversity of a 12-mer T7 phage-displayed peptide library randomized using codon-corrected trinucleotide cassettes with a T7 and an M13 12-mer phage-displayed peptide library constructed using the degenerate codon randomization method. We herein demonstrate that the combination of trinucleotide cassette amino acid codon randomization and T7 phage display construction methods resulted in a significant enhancement to the functional diversity of a 12-mer peptide library. This novel library exhibited superior amino acid uniformity and order-of-magnitude increases in amino acid sequence diversity as compared to degenerate codon randomized peptide libraries. Comparative analyses of the biophysical characteristics of the 12-mer peptide libraries revealed the trinucleotide cassette-randomized library to be a unique resource. The combination of T7 phage display and trinucleotide cassette randomization resulted in a novel resource for the potential isolation of binding peptides for new and previously studied molecular targets. JF - BMC biotechnology AU - Krumpe, Lauren R H AU - Schumacher, Kathryn M AU - McMahon, James B AU - Makowski, Lee AU - Mori, Toshiyuki AD - Molecular Targets Development Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland 21702, USA. lhaugh@ncifcrf.gov Y1 - 2007/10/05/ PY - 2007 DA - 2007 Oct 05 SP - 65 VL - 7 KW - Peptide Library KW - 0 KW - Peptides KW - Streptavidin KW - 9013-20-1 KW - Index Medicus KW - Molecular Sequence Data KW - Bacteriophage M13 KW - Peptides -- chemistry KW - Streptavidin -- metabolism KW - Amino Acid Sequence KW - Peptides -- isolation & purification KW - Genetic Variation KW - Trinucleotide Repeats -- genetics KW - Bacteriophage T7 -- genetics KW - Mutagenesis, Insertional -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69086147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+biotechnology&rft.atitle=Trinucleotide+cassettes+increase+diversity+of+T7+phage-displayed+peptide+library.&rft.au=Krumpe%2C+Lauren+R+H%3BSchumacher%2C+Kathryn+M%3BMcMahon%2C+James+B%3BMakowski%2C+Lee%3BMori%2C+Toshiyuki&rft.aulast=Krumpe&rft.aufirst=Lauren+R&rft.date=2007-10-05&rft.volume=7&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=BMC+biotechnology&rft.issn=1472-6750&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-30 N1 - Date created - 2008-01-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Mol Biol. 2002 Oct 4;322(5):1039-52 [12367527] Bioinformatics. 2003 Mar 1;19(4):483-9 [12611803] J Recept Signal Transduct Res. 2003;23(4):307-49 [14753295] Drug Discov Today. 2004 Jun 15;9(12):525-9 [15183160] Proteomics. 2004 May;4(5):1439-60 [15188413] Curr Pharm Des. 2004;10(19):2335-43 [15279612] Proteomics. 2006 Aug;6(15):4210-22 [16819727] J Mol Biol. 1982 May 5;157(1):105-32 [7108955] Nucleic Acids Res. 1994 Dec 25;22(25):5600-7 [7838712] Nucleic Acids Res. 1996 Oct 1;24(19):3748-55 [8871554] Curr Opin Biotechnol. 1999 Feb;10(1):87-93 [10047512] Bioinformatics. 2004 Dec 12;20(18):3481-9 [15284106] J Biol Chem. 2006 Aug 25;281(34):24472-8 [16787913] Adv Enzymol Relat Areas Mol Biol. 1978;47:45-148 [364941] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of residues important for agonist recognition and activation in GPR40. AN - 68342626; 17699519 AB - GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor, now named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. Guided by molecular modeling, we investigated the molecular determinants contributing to binding of linoleic acid, a C18 polyunsaturated FFA, and GW9508, a synthetic small molecule agonist. Twelve residues within the putative GPR40-binding pocket including hydrophilic/positively charged, aromatic, and hydrophobic residues were identified and were subjected to site-directed mutagenesis. Our results suggest that linoleic acid and GW9508 are anchored on their carboxylate groups by Arg(183), Asn(244), and Arg(258). Moreover, His(86), Tyr(91), and His(137) may contribute to aromatic and/or hydrophobic interactions with GW9508 that are not present, or relatively weak, with linoleic acid. The anchor residues, as well as the residues Tyr(12), Tyr(91), His(137), and Leu(186), appear to be important for receptor activation also. Interestingly, His(137) and particularly His(86) may interact with GW9508 in a manner dependent on its protonation status. The greater number of putative interactions between GPR40 and GW9508 compared with linoleic acid may explain the higher potency of GW9508. JF - The Journal of biological chemistry AU - Sum, Chi Shing AU - Tikhonova, Irina G AU - Neumann, Susanne AU - Engel, Stanislav AU - Raaka, Bruce M AU - Costanzi, Stefano AU - Gershengorn, Marvin C AD - Clinical Endocrinology Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/10/05/ PY - 2007 DA - 2007 Oct 05 SP - 29248 EP - 29255 VL - 282 IS - 40 SN - 0021-9258, 0021-9258 KW - FFAR1 protein, human KW - 0 KW - Fatty Acids, Nonesterified KW - GW9508 KW - Methylamines KW - Propionates KW - Receptors, G-Protein-Coupled KW - Linoleic Acid KW - 9KJL21T0QJ KW - Index Medicus KW - Dose-Response Relationship, Drug KW - Humans KW - Propionates -- pharmacology KW - Amino Acid Sequence KW - Propionates -- chemistry KW - Protein Binding KW - Mutagenesis, Site-Directed KW - Methylamines -- chemistry KW - Molecular Sequence Data KW - Models, Chemical KW - Cell Membrane -- metabolism KW - Molecular Conformation KW - Protein Structure, Tertiary KW - Cell Line KW - Methylamines -- pharmacology KW - Fatty Acids, Nonesterified -- chemistry KW - Receptors, G-Protein-Coupled -- chemistry KW - Linoleic Acid -- chemistry KW - Receptors, G-Protein-Coupled -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68342626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Identification+of+residues+important+for+agonist+recognition+and+activation+in+GPR40.&rft.au=Sum%2C+Chi+Shing%3BTikhonova%2C+Irina+G%3BNeumann%2C+Susanne%3BEngel%2C+Stanislav%3BRaaka%2C+Bruce+M%3BCostanzi%2C+Stefano%3BGershengorn%2C+Marvin+C&rft.aulast=Sum&rft.aufirst=Chi&rft.date=2007-10-05&rft.volume=282&rft.issue=40&rft.spage=29248&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selective Cysteine Protease Inhibition Contributes to Blood-feeding Success of the Tick Ixodes scapularis AN - 20315214; 7614127 AB - Ixodes scapularis is the main vector of Lyme disease in the eastern and central United States. Tick salivary secretion has been shown as important for both blood-meal completion and pathogen transmission. Here we report a duplication event of cystatin genes in its genome that results in a transcription-regulated boost of saliva inhibitory activity against a conserved and relatively limited number of vertebrate papain-like cysteine proteases during blood feeding. We further show that the polypeptide products of the two genes differ in their binding affinity for some enzyme targets, and they display different antigenicity. Moreover, our reverse genetic approach employing RNA interference uncovered a crucial mediation in tick-feeding success. Given the role of the targeted enzymes in vertebrate immunity, we also show that host immunomodulation is implicated in the deleterious phenotype of silenced ticks making I. scapularis cystatins attractive targets for development of antitick vaccines. JF - Journal of Biological Chemistry AU - Kotsyfakis, Michalis AU - Karim, Shahid AU - Andersen, John F AU - Mather, Thomas N AU - Ribeiro, Jose MC AD - Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852 and the Center for Vector-Borne Disease, University of Rhode Island, Kingston, Rhode Island 02881 Y1 - 2007/10/05/ PY - 2007 DA - 2007 Oct 05 SP - 29256 EP - 29263 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 40 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Immunology Abstracts KW - Genomes KW - Feeding KW - Antigenicity KW - Ixodidae KW - Transcription KW - Vectors KW - Enzymes KW - Ixodes scapularis KW - Blood meals KW - Pathogens KW - Immunity KW - Immunomodulation KW - Disease transmission KW - Cystatin KW - Blood KW - Borrelia KW - RNA-mediated interference KW - Saliva KW - Vaccines KW - Lyme disease KW - Cysteine proteinase KW - F 06905:Vaccines KW - Z 05350:Medical, Veterinary, and Agricultural Entomology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20315214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Selective+Cysteine+Protease+Inhibition+Contributes+to+Blood-feeding+Success+of+the+Tick+Ixodes+scapularis&rft.au=Kotsyfakis%2C+Michalis%3BKarim%2C+Shahid%3BAndersen%2C+John+F%3BMather%2C+Thomas+N%3BRibeiro%2C+Jose+MC&rft.aulast=Kotsyfakis&rft.aufirst=Michalis&rft.date=2007-10-05&rft.volume=282&rft.issue=40&rft.spage=29256&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Feeding; Antigenicity; Enzymes; Vectors; Transcription; Immunity; Pathogens; Blood meals; Immunomodulation; Disease transmission; Blood; Cystatin; RNA-mediated interference; Vaccines; Saliva; Cysteine proteinase; Lyme disease; Ixodidae; Borrelia; Ixodes scapularis ER - TY - JOUR T1 - What a difference a decade makes: insights into translesion DNA synthesis. AN - 68338060; 17898175 AB - Living organisms are continually under attack from a vast array of DNA-damaging agents that imperils their genomic integrity. As a consequence, cells possess an army of enzymes to repair their damaged chromosomes. However, DNA lesions often persist and pose a considerable threat to survival, because they can block the cell's replicase and its ability to complete genome duplication. It has been clear for many years that cells must possess a mechanism whereby the DNA lesion could be tolerated and physically bypassed. Yet it was only within the past decade that specialized DNA polymerases for "translesion DNA synthesis" or "TLS" were identified and characterized. Many of the TLS enzymes belong to the recently described "Y-family" of DNA polymerases. By possessing a spacious preformed active site, these enzymes can physically accommodate a variety of DNA lesions and facilitate their bypass. Flexible DNA-binding domains and a variable binding pocket for the replicating base pair further allow these TLS polymerases to select specific lesions to bypass and favor distinct non-Watson-Crick base pairs. Consequently, TLS polymerases tend to exhibit much lower fidelity than the cell's replicase when copying normal DNA, which results in a dramatic increase in mutagenesis. Occasionally this can be beneficial, but it often speeds the onset of cancer in humans. Cells use both transcriptional and posttranslational regulation to keep these low-fidelity polymerases under strict control and limit their access to a replication fork. Our perspective focuses on the mechanistic insights into TLS by the Y-family polymerases, how they are regulated, and their effects on genomic (in)stability that have been described in the past decade. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Yang, Wei AU - Woodgate, Roger AD - National Institute of Diabetes and Digestive and Kidney Diseases and Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. wei.yang@nih.gov Y1 - 2007/10/02/ PY - 2007 DA - 2007 Oct 02 SP - 15591 EP - 15598 VL - 104 IS - 40 SN - 0027-8424, 0027-8424 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Base Pairing KW - DNA -- chemistry KW - Nucleic Acid Conformation KW - DNA Damage KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338060?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=What+a+difference+a+decade+makes%3A+insights+into+translesion+DNA+synthesis.&rft.au=Yang%2C+Wei%3BWoodgate%2C+Roger&rft.aulast=Yang&rft.aufirst=Wei&rft.date=2007-10-02&rft.volume=104&rft.issue=40&rft.spage=15591&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2006 Feb 20;203(2):319-23 [16476771] Biochemistry. 2006 Mar 7;45(9):2772-8 [16503632] Mol Immunol. 2006 Apr;43(10):1587-94 [16263170] PLoS Biol. 2006 Jan;4(1):e11 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[16929290] J Biol Chem. 1999 Nov 5;274(45):31763-6 [10542196] Front Biosci. 1999 Dec 1;4:D849-58 [10577396] Genes Cells. 1999 Nov;4(11):607-18 [10620008] J Biol Chem. 2000 Mar 17;275(11):7447-50 [10713043] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3838-43 [10760255] Biochemistry. 2000 Apr 25;39(16):4575-80 [10769112] EMBO J. 2000 Jun 15;19(12):3100-9 [10856253] Genes Dev. 2000 Jul 1;14(13):1589-94 [10887153] Genes Dev. 2000 Jul 1;14(13):1642-50 [10887158] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors of Language Acquisition in Preschool Children with Autism Spectrum Disorders AN - 85686237; 200808791 AB - In 118 children followed from age 2 to 5 (59 with autism, 24 with PDD-NOS and 35 with non-spectrum developmental disabilities), age 2 and age 3 scores of non-verbal ability, receptive communication, expressive communication and socialization were compared as predictors of receptive and expressive language at age 5. Non-verbal cognitive ability at age 2 was generally the strongest predictor of age 5 language, while at age 3 communication scores were a stronger predictor of age 5 language for children with autism. Early joint attention as well as vocal and motor imitation skills were more impaired in children who did not develop language by age 5 (but had relatively strong non-verbal cognitive skills) than in children who did develop language by 5. Adapted from the source document JF - Journal of Autism and Developmental Disorders AU - Thurm, Audrey AU - Lord, Catherine AU - Lee, Li-Ching AU - Newschaffer, Craig AD - Pediatric and Developmental Neuropsychiatry Branch, National Institute of Mental Health, 10 Center Drive MSC 1255, Building 10, 4N208, Bethesda, MD 20892-1255, USA athurm@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1721 EP - 1734 VL - 37 IS - 9 SN - 0162-3257, 0162-3257 KW - Autism (06800) KW - Imitation (34600) KW - Developmental Disabilities (18450) KW - Psychometric Analysis (69210) KW - Preschool Children (67350) KW - Language Acquisition (41600) KW - Socialization (80000) KW - Joint Attention (39760) KW - Communicative Competence (13650) KW - article KW - 6610: mental retardation; mental retardation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85686237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Autism+and+Developmental+Disorders&rft.atitle=Predictors+of+Language+Acquisition+in+Preschool+Children+with+Autism+Spectrum+Disorders&rft.au=Thurm%2C+Audrey%3BLord%2C+Catherine%3BLee%2C+Li-Ching%3BNewschaffer%2C+Craig&rft.aulast=Thurm&rft.aufirst=Audrey&rft.date=2007-10-01&rft.volume=37&rft.issue=9&rft.spage=1721&rft.isbn=&rft.btitle=&rft.title=Journal+of+Autism+and+Developmental+Disorders&rft.issn=01623257&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JADDDQ N1 - SubjectsTermNotLitGenreText - Autism (06800); Developmental Disabilities (18450); Psychometric Analysis (69210); Communicative Competence (13650); Socialization (80000); Joint Attention (39760); Imitation (34600); Language Acquisition (41600); Preschool Children (67350) ER - TY - JOUR T1 - Cochlear implantation for hearing loss associated with bilateral endolymphatic sac tumors in von Hippel-Lindau disease. AN - 85404451; pmid-17468670 AB - Bilateral endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and often underlie significant audiovestibular morbidity, including hearing loss.This 44-year-old female von Hippel-Lindau disease patient presented with tinnitus, vertigo, and binaural hearing loss. Magnetic resonance and computed tomography imaging demonstrated bilateral ELSTs, and audiometry confirmed bilateral hearing loss.The patient underwent staged resection of the ELSTs (left then right). After resection of the left ELST and during the same operation, a cochlear implant was placed.Clinical, audiometric, and imaging data.Postoperatively, the patient had resolution of tinnitus and vertigo with a significant implant-aided improvement in hearing.Because of their unique anatomic and biologic features, resection of bilateral tumors and cochlear implantation in deaf ELST patients is a potential option to improve hearing and quality of life. JF - Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology AU - Jagannathan, Jay AU - Lonser, Russell R AU - Stanger, Richard A AU - Butman, John A AU - Vortmeyer, Alexander O AU - Zalewski, Christopher K AU - Brewer, Carmen AU - Surowicz, Christal AU - Kim, H Jeffrey AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 927 EP - 930 VL - 28 IS - 7 SN - 1531-7129, 1531-7129 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Audiometry KW - *Cochlear Implantation KW - *Ear Neoplasms: complications KW - *Ear Neoplasms: pathology KW - Ear Neoplasms: surgery KW - *Endolymphatic Sac: pathology KW - Endolymphatic Sac: surgery KW - Female KW - *Hearing Loss: etiology KW - *Hearing Loss: surgery KW - Humans KW - Magnetic Resonance Imaging KW - Otologic Surgical Procedures KW - Tinnitus: complications KW - Tomography, X-Ray Computed KW - Vertigo: complications KW - *von Hippel-Lindau Disease: complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85404451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.atitle=Cochlear+implantation+for+hearing+loss+associated+with+bilateral+endolymphatic+sac+tumors+in+von+Hippel-Lindau+disease.&rft.au=Jagannathan%2C+Jay%3BLonser%2C+Russell+R%3BStanger%2C+Richard+A%3BButman%2C+John+A%3BVortmeyer%2C+Alexander+O%3BZalewski%2C+Christopher+K%3BBrewer%2C+Carmen%3BSurowicz%2C+Christal%3BKim%2C+H+Jeffrey&rft.aulast=Jagannathan&rft.aufirst=Jay&rft.date=2007-10-01&rft.volume=28&rft.issue=7&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=Otology+%26+neurotology+%3A+official+publication+of+the+American+Otological+Society%2C+American+Neurotology+Society+%5Band%5D+European+Academy+of+Otology+and+Neurotology&rft.issn=15317129&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Otol Neurotol. 2007 Dec;28(8):1159; author reply 1161[17728688] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. AN - 70736433; 17471493 AB - Prostasin (CAP1/PRSS8) is a glycosylphosphatidylinositol-anchored membrane serine protease believed to be critical for the regulation of epithelial sodium channel (ENaC) activity. Prostasin is synthesized as an inactive zymogen that requires a site-specific endoproteolytic cleavage to be converted to an active protease. We have recently reported that the tumor-associated type II transmembrane serine protease, matriptase is necessary and sufficient for prostasin activation in the epidermis. In this study, the interrelationship between the two membrane serine proteases was investigated further by using enzymatic gene trapping combined with immunohistochemistry to delineate the spatial expression of matriptase and prostasin in mouse tissues. We utilized a knock-in mouse with a promoterless beta-galactosidase marker gene inserted into the matriptase locus, as a unique tool for precise assessment of endogenous matriptase expression. The spatial expression of matriptase and prostasin in mouse tissues was delineated by combining in situ beta-galactosidase matriptase staining with immunohistochemical detection of prostasin. We report that prostasin displays a near-ubiquitous co-localization with its candidate activator matriptase in a variety of normal epithelial tissues. These include simple, stratified, and pseudo-stratified epithelium of the integumentary system, digestive tract, respiratory tract, and urogenital tract. However, matriptase and prostasin expression segregates during epithelial multi-stage carcinogenesis to eventually become localized in separate compartments of the tumor. These data suggest that a matriptase-prostasin zymogen activation cascade may be functionally operative in multiple epithelial tissues, but matriptase promotes epithelial carcinogenesis independent of prostasin. (c) 2007 Wiley-Liss, Inc. JF - Journal of cellular physiology AU - List, Karin AU - Hobson, John P AU - Molinolo, Alfredo AU - Bugge, Thomas H AD - Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 237 EP - 245 VL - 213 IS - 1 SN - 0021-9541, 0021-9541 KW - Epithelial Sodium Channels KW - 0 KW - Serine Endopeptidases KW - EC 3.4.21.- KW - matriptase KW - prostasin KW - Index Medicus KW - Epithelial Sodium Channels -- metabolism KW - Animals KW - Neoplasms, Glandular and Epithelial -- genetics KW - Neoplasms, Glandular and Epithelial -- metabolism KW - Neoplasms, Glandular and Epithelial -- etiology KW - Mice KW - Epithelium -- metabolism KW - Tissue Distribution KW - Mice, Transgenic KW - Male KW - Female KW - Serine Endopeptidases -- metabolism KW - Serine Endopeptidases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70736433?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+cellular+physiology&rft.atitle=Co-localization+of+the+channel+activating+protease+prostasin%2F%28CAP1%2FPRSS8%29+with+its+candidate+activator%2C+matriptase.&rft.au=List%2C+Karin%3BHobson%2C+John+P%3BMolinolo%2C+Alfredo%3BBugge%2C+Thomas+H&rft.aulast=List&rft.aufirst=Karin&rft.date=2007-10-01&rft.volume=213&rft.issue=1&rft.spage=237&rft.isbn=&rft.btitle=&rft.title=Journal+of+cellular+physiology&rft.issn=00219541&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-26 N1 - Date created - 2007-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of lipid peroxidation and enhancement of GST activity by cardamom and cinnamon during chemically induced colon carcinogenesis in Swiss albino mice. AN - 70090694; 18260732 AB - Globally, colorectal cancer is the third commonest cancer in men since 1975.The present study focuses on the preventive strategies aimed at reducing the incidences and mortality of large bowel cancer. Chemoprevention of colon cancer appears to be a very realistic possibility because various intermediate stages have been identified preceding the development of malignant colonic tumors. Several studies have demonstrated that generous consumption of vegetables reduces the risk of colon cancer. This idea has prompted the present investigation to search for some novel plant products, which may have possible anticarcinogenic activity. It has already been proved from various experiments that chemopreventive agents, by virtue of their anti-oxidant, anti-inflammatory, anti-proliferative, apoptosis-inducing activity, act at various levels including molecular, cellular, tissue and organ levels to interfere with carcinogens. Previous studies from our laboratory have already reported the inhibitory effect of cinnamon and cardamom on azoxymethane induced colon carcinogenesis by virtue of their anti-inflammatory, anti-proliferative and pro-apoptotic activity. This particular experiment was carried out to assess the anti-oxidative potential of these spices. Aqueous suspensions of cinnamon and cardamom have been shown to enhance the level of detoxifying enzyme (GST activity) with simultaneous decrease in lipid peroxidation levels in the treatment groups when compared to that of the carcinogen control group. JF - Asian Pacific journal of cancer prevention : APJCP AU - Bhattacharjee, Shamee AU - Rana, Tapasi AU - Sengupta, Archana AD - Dept of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India. PY - 2007 SP - 578 EP - 582 VL - 8 IS - 4 SN - 1513-7368, 1513-7368 KW - Carcinogens KW - 0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Azoxymethane KW - MO0N1J0SEN KW - Index Medicus KW - Animals KW - Liver -- enzymology KW - Azoxymethane -- toxicity KW - Colon -- enzymology KW - Carcinogens -- toxicity KW - Mice KW - Phytotherapy KW - Precancerous Conditions -- chemically induced KW - Elettaria KW - Precancerous Conditions -- prevention & control KW - Glutathione Transferase -- metabolism KW - Lipid Peroxidation -- drug effects KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced KW - Cinnamomum zeylanicum KW - Precancerous Conditions -- enzymology KW - Colonic Neoplasms -- enzymology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70090694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Inhibition+of+lipid+peroxidation+and+enhancement+of+GST+activity+by+cardamom+and+cinnamon+during+chemically+induced+colon+carcinogenesis+in+Swiss+albino+mice.&rft.au=Bhattacharjee%2C+Shamee%3BRana%2C+Tapasi%3BSengupta%2C+Archana&rft.aulast=Bhattacharjee&rft.aufirst=Shamee&rft.date=2007-10-01&rft.volume=8&rft.issue=4&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-01-15 N1 - Date created - 2008-02-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - ABC drug transporters as molecular targets for the prevention of multidrug resistance and drug-drug interactions. AN - 68468526; 17979652 AB - ABC transporters play an important role in mediating the cytoplasmic concentration of endogenous and xenobiotic substances. They therefore influence the pharmacokinetic profile of a variety of drugs. By virtue of their localization to plasma membranes in the intestine, liver, blood-brain and other vital biological barriers, a majority of ABC drug transporters cause drug-drug interactions, decreased drug efficacy and multidrug resistance for chemotherapeutic agents. Thus, elucidating which drug entities are substrates for ABC drug transporters is a crucial step in the drug development and treatment process. Here, we review the current status of methodology used to categorize drug compounds as substrates or modulators for the major ABC drug transporters including ABCB1, ABCC1 and ABCG2. JF - Current drug delivery AU - Calcagno, Anna Maria AU - Kim, In-Wha AU - Wu, Chung-Pu AU - Shukla, Suneet AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH/DHHS, Bethesda, MD 20892, USA. calcagnoa@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 324 EP - 333 VL - 4 IS - 4 SN - 1567-2018, 1567-2018 KW - Index Medicus KW - Animals KW - Humans KW - Biological Transport KW - Drug Design KW - Pharmacokinetics KW - Drug Delivery Systems KW - ATP-Binding Cassette Transporters -- drug effects KW - Drug Interactions KW - ATP-Binding Cassette Transporters -- metabolism KW - Drug Resistance, Multiple UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68468526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+delivery&rft.atitle=ABC+drug+transporters+as+molecular+targets+for+the+prevention+of+multidrug+resistance+and+drug-drug+interactions.&rft.au=Calcagno%2C+Anna+Maria%3BKim%2C+In-Wha%3BWu%2C+Chung-Pu%3BShukla%2C+Suneet%3BAmbudkar%2C+Suresh+V&rft.aulast=Calcagno&rft.aufirst=Anna&rft.date=2007-10-01&rft.volume=4&rft.issue=4&rft.spage=324&rft.isbn=&rft.btitle=&rft.title=Current+drug+delivery&rft.issn=15672018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-29 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Investigation of xenobiotics metabolism, genotoxicity, and carcinogenicity using Cyp2e1(-/-) mice. AN - 68468311; 17979661 AB - Cytochromes P450 (CYPs) comprise a number of enzyme subfamilies responsible for the oxidative metabolism of a wide range of therapeutic agents, environmental toxicants, mutagens, and carcinogens. In particular, cytochrome P450 2E1 (CYP2E1) is implicated in the oxidative bioactivation of a variety of small hydrophobic chemicals including a number of epoxide-forming drugs and environmentally important toxicants including urethane, acrylamide, acrylonitrile, benzene, vinyl chloride, styrene, 1-bromopropane, trichloroethylene, dichloroethylene, acetaminophen, and butadiene. Until recently, chemical modulators (inducers and inhibitors) were used in order to characterize the enzymatic basis of xenobiotic metabolism and the relationships between CYP-mediated bioactivation and chemical-induced toxicity/carcinogenicity. With the advent of genetically engineered knockout mice, the ability to evaluate the roles of specific CYPs in the metabolism of xenobiotics has become more attainable. The main focus of the current review is to present studies that characterized the enzymatic, metabolic, and molecular mechanisms of toxicity, genotoxicity, and carcinogenicity of various xenobiotics using Cyp2e1-/- mice. Data presented in this review demonstrated that the most comprehensive studies using Cyp2e1-/- mice, encompassing the entire paradigm of metabolism to toxicity, genotoxicity, and carcinogenicity were possible when a substrate was primarily metabolized via CYP2E1 (e.g. urethane and acrylamide). In contrast, when multiple CYP enzymes were prevalent in the oxidation of a particular substrate (e.g.: trichloroethylene, methacrylonitrile, crotononitrile), investigating the relationships between oxidative metabolism and biological activity became more complicated and required the use of chemical modulators. In conclusion, the current review showed that Cyp2e1-/- mice are a valuable animal model for the investigation of the metabolic and molecular basis of toxicity, genotoxicity, and carcinogenicity of xenobiotics. JF - Current drug metabolism AU - Ghanayem, Burhan I AU - Hoffler, Undi AD - Metabolism and Exposure Markers Section, Laboratory of Pharmacology and Chemistry, National Toxicology Program, NIEHS, NIH, RTP, NC 27709, USA. Ghanayem@niehs.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 728 EP - 749 VL - 8 IS - 7 SN - 1389-2002, 1389-2002 KW - Carcinogens KW - 0 KW - Mutagens KW - Xenobiotics KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Mutagenicity Tests -- methods KW - Biotransformation KW - Carcinogens -- toxicity KW - Carcinogenicity Tests -- methods KW - Mutagens -- toxicity KW - Mice KW - Mice, Knockout KW - Models, Animal KW - Xenobiotics -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Xenobiotics -- toxicity KW - Cytochrome P-450 CYP2E1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68468311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+metabolism&rft.atitle=Investigation+of+xenobiotics+metabolism%2C+genotoxicity%2C+and+carcinogenicity+using+Cyp2e1%28-%2F-%29+mice.&rft.au=Ghanayem%2C+Burhan+I%3BHoffler%2C+Undi&rft.aulast=Ghanayem&rft.aufirst=Burhan&rft.date=2007-10-01&rft.volume=8&rft.issue=7&rft.spage=728&rft.isbn=&rft.btitle=&rft.title=Current+drug+metabolism&rft.issn=13892002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS). AN - 68467584; 17979580 AB - The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS). One hundred and forty preschoolers with ADHD, who had improved with acute immediate-release methylphenidate (IR-MPH) treatment, entered a 10-month, open-label medication maintenance at six sites. Assessments included the Clinical Global Impression-Severity (CGI-S), CGI-Improvement (CGI-I), Children's Global Assessment Scale (C-GAS), Swanson, Nolan, and Pelham Questionnaire (SNAP), Scale Strengths and Weaknesses of ADHD-Symptoms and Normal Behaviors (SWAN), Social Competence Scale, Social Skills Rating System (SSRS), and Parenting Stress Index-Short Form (PSI-SF). For the 95 children who completed the 10-month treatment, improvement occurred on the CGI-S (p = 0.02), CGI-I (p < 0.01), C-GAS (p = 0.001), and SSRS (p = 0.01). SNAP and SWAN scores remained stable. Forty five children discontinued: 7 for adverse effects, 7 for behavior worsening, 7 for switching to long-acting stimulants, 3 for inadequate benefit, and 21 for other reasons. The mean MPH dose increased from 14.04 mg/day +/- SD 7.57 (0.71 +/- 0.38 mg/kg per day) at month 1 to 19.98 mg/day +/- 9.56 (0.92 +/- 0.40 mg/kg per day) at month 10. With careful monitoring and gradual medication dose increase, most preschoolers with ADHD maintained improvement during long-term IR-MPH treatment. There was substantial variability in effective and tolerated dosing. JF - Journal of child and adolescent psychopharmacology AU - Vitiello, Benedetto AU - Abikoff, Howard B AU - Chuang, Shirley Z AU - Kollins, Scott H AU - McCracken, James T AU - Riddle, Mark A AU - Swanson, James M AU - Wigal, Tim AU - McGough, James J AU - Ghuman, Jaswinder K AU - Wigal, Sharon B AU - Skrobala, Anne M AU - Davies, Mark AU - Posner, Kelly AU - Cunningham, Charles AU - Greenhill, Laurence L AD - Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA. bvitiell@nail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 593 EP - 604 VL - 17 IS - 5 SN - 1044-5463, 1044-5463 KW - Central Nervous System Stimulants KW - 0 KW - Methylphenidate KW - 207ZZ9QZ49 KW - Index Medicus KW - Socioeconomic Factors KW - Psychiatric Status Rating Scales KW - Dose-Response Relationship, Drug KW - Humans KW - Patient Dropouts KW - Neuropsychological Tests KW - Male KW - Female KW - Stress, Psychological -- psychology KW - Parents -- psychology KW - Child, Preschool KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Attention Deficit Disorder with Hyperactivity -- diagnosis KW - Methylphenidate -- adverse effects KW - Methylphenidate -- therapeutic use KW - Central Nervous System Stimulants -- therapeutic use KW - Central Nervous System Stimulants -- adverse effects KW - Attention Deficit Disorder with Hyperactivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68467584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+child+and+adolescent+psychopharmacology&rft.atitle=Effectiveness+of+methylphenidate+in+the+10-month+continuation+phase+of+the+Preschoolers+with+Attention-Deficit%2FHyperactivity+Disorder+Treatment+Study+%28PATS%29.&rft.au=Vitiello%2C+Benedetto%3BAbikoff%2C+Howard+B%3BChuang%2C+Shirley+Z%3BKollins%2C+Scott+H%3BMcCracken%2C+James+T%3BRiddle%2C+Mark+A%3BSwanson%2C+James+M%3BWigal%2C+Tim%3BMcGough%2C+James+J%3BGhuman%2C+Jaswinder+K%3BWigal%2C+Sharon+B%3BSkrobala%2C+Anne+M%3BDavies%2C+Mark%3BPosner%2C+Kelly%3BCunningham%2C+Charles%3BGreenhill%2C+Laurence+L&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2007-10-01&rft.volume=17&rft.issue=5&rft.spage=593&rft.isbn=&rft.btitle=&rft.title=Journal+of+child+and+adolescent+psychopharmacology&rft.issn=10445463&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2007-11-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interactions of HIV and methamphetamine: cellular and molecular mechanisms of toxicity potentiation. AN - 68454649; 17967742 AB - Methamphetamine (METH) is a highly addictive psychostimulant drug, whose abuse has reached epidemic proportions worldwide. METH use is disproportionally represented among populations at high risks for developing HIV infection or who are already infected with the virus. Psychostimulant abuse has been reported to exacerbate the cognitive deficits and neurodegenerative abnormalities observed in HIV-positive patients. Thus, the purpose of the present paper is to review the clinical and basic observations that METH potentiates the adverse effects of HIV infection. An additional purpose is to provide a synthesis of the cellular and molecular mechanisms that might be responsible for the increased toxicity observed in co-morbid patients. The reviewed data indicate that METH and HIV proteins, including gp120, gp41, Tat, Vpr and Nef, converge on various caspase-dependent death pathways to cause neuronal apoptosis. The role of reactive microgliosis in METH- and in HIV-induced toxicity is also discussed. JF - Neurotoxicity research AU - Cadet, J L AU - Krasnova, I N AD - Molecular Neuropsychiatry Branch, NIH/NIDA Intramural Research Program, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 181 EP - 204 VL - 12 IS - 3 SN - 1029-8428, 1029-8428 KW - Central Nervous System Stimulants KW - 0 KW - Human Immunodeficiency Virus Proteins KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Animals KW - Gene Expression Regulation, Viral -- physiology KW - Humans KW - Apoptosis -- physiology KW - Neurotoxicity Syndromes -- etiology KW - Human Immunodeficiency Virus Proteins -- metabolism KW - Apoptosis -- drug effects KW - Gene Expression Regulation, Viral -- drug effects KW - Amphetamine-Related Disorders -- epidemiology KW - Amphetamine-Related Disorders -- metabolism KW - Amphetamine-Related Disorders -- complications KW - HIV Infections -- complications KW - Methamphetamine -- adverse effects KW - HIV Infections -- metabolism KW - Central Nervous System Stimulants -- adverse effects KW - HIV Infections -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68454649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+research&rft.atitle=Interactions+of+HIV+and+methamphetamine%3A+cellular+and+molecular+mechanisms+of+toxicity+potentiation.&rft.au=Cadet%2C+J+L%3BKrasnova%2C+I+N&rft.aulast=Cadet&rft.aufirst=J&rft.date=2007-10-01&rft.volume=12&rft.issue=3&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+research&rft.issn=10298428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-29 N1 - Date created - 2007-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Poly(ADP-ribose) polymerase-1 and its clinical applications in brain injury. AN - 68439460; 17966294 AB - Traumatic brain injury (TBI) is a devastating occurrence that may result in short- and long-term complications. Oxidative stress (an imbalance between oxidants and antioxidants) plays a critical role in the development of secondary injuries following TBI and, consequently, in patient outcomes. Secondary injuries resulting from oxidative stress produce DNA strand breaks that activate poly(adenosine diphosphate [ADP]-ribose) polymerase-1 (PARP-1) and produce another level of injury. PARP-1 functions as a DNA-damage sensor and signaling molecule. In response to the severe DNA damage after brain injury, PARP-1 becomes overactivated and depletes the cells' energy sources, which leads to cellular and neuronal death. Recently, PARP-1 inhibition has been studied in various animal models of brain injury with promising results. TBI treatments based on PARP-1 inhibition in humans are far from the clinical arena, although descriptive studies of PARP-1 activation in humans are beginning to emerge. Nurses should become involved in this area of collaborative research in human response to brain injury by helping design and implement safe and meaningful clinical trials. JF - The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses AU - Barr, Taura L AU - Conley, Yvette P AD - National Institute of Nursing Research, Bethesda, MD, USA. barrt@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 278 EP - 284 VL - 39 IS - 5 SN - 0888-0395, 0888-0395 KW - Free Radicals KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Poly(ADP-ribose) Polymerase Inhibitors KW - PARP1 protein, human KW - EC 2.4.2.30 KW - Poly (ADP-Ribose) Polymerase-1 KW - Poly(ADP-ribose) Polymerases KW - Index Medicus KW - Nursing KW - Health Services Needs and Demand KW - Free Radicals -- adverse effects KW - Apoptosis KW - Nursing Assessment KW - Humans KW - Practice Guidelines as Topic KW - Clinical Trials as Topic KW - Nurse's Role KW - Critical Care -- methods KW - Intracellular Signaling Peptides and Proteins -- physiology KW - Brain Injuries -- therapy KW - Oxidative Stress -- physiology KW - DNA Damage -- physiology KW - Oxidative Stress -- drug effects KW - Brain Injuries -- immunology KW - Brain Injuries -- enzymology KW - Poly(ADP-ribose) Polymerases -- physiology KW - Brain Injuries -- complications KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68439460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.atitle=Poly%28ADP-ribose%29+polymerase-1+and+its+clinical+applications+in+brain+injury.&rft.au=Barr%2C+Taura+L%3BConley%2C+Yvette+P&rft.aulast=Barr&rft.aufirst=Taura&rft.date=2007-10-01&rft.volume=39&rft.issue=5&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+nursing+%3A+journal+of+the+American+Association+of+Neuroscience+Nurses&rft.issn=08880395&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A corkscrew model for dynamin constriction. AN - 68403924; 17937909 AB - Numerous vesiculation processes throughout the eukaryotic cell are dependent on the protein dynamin, a large GTPase that constricts lipid bilayers. We have combined X-ray crystallography and cryo-electron microscopy (cryo-EM) data to generate a coherent model of dynamin-mediated membrane constriction. GTPase and pleckstrin homology domains of dynamin were fit to cryo-EM structures of human dynamin helices bound to lipid in nonconstricted and constricted states. Proteolysis and immunogold labeling experiments confirm the topology of dynamin domains predicted from the helical arrays. Based on the fitting, an observed twisting motion of the GTPase, middle, and GTPase effector domains coincides with conformational changes determined by cryo-EM. We propose a corkscrew model for dynamin constriction based on these motions and predict regions of sequence important for dynamin function as potential targets for future mutagenic and structural studies. JF - Structure (London, England : 1993) AU - Mears, Jason A AU - Ray, Pampa AU - Hinshaw, Jenny E AD - Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 8 Center Drive, MSC 0851, Bethesda, MD 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1190 EP - 1202 VL - 15 IS - 10 SN - 0969-2126, 0969-2126 KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Dynamins KW - EC 3.6.5.5 KW - Index Medicus KW - GTP Phosphohydrolases -- chemistry KW - GTP Phosphohydrolases -- metabolism KW - Molecular Sequence Data KW - Crystallography, X-Ray KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Immunohistochemistry KW - Protein Conformation KW - Dynamins -- chemistry KW - Dynamins -- metabolism KW - Models, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68403924?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure+%28London%2C+England+%3A+1993%29&rft.atitle=A+corkscrew+model+for+dynamin+constriction.&rft.au=Mears%2C+Jason+A%3BRay%2C+Pampa%3BHinshaw%2C+Jenny+E&rft.aulast=Mears&rft.aufirst=Jason&rft.date=2007-10-01&rft.volume=15&rft.issue=10&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=Structure+%28London%2C+England+%3A+1993%29&rft.issn=09692126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-13 N1 - Date created - 2007-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2004 Sep 24;279(39):40431-6 [15262989] J Struct Biol. 2004 Sep;147(3):259-67 [15450295] J Neurosci. 1989 Nov;9(11):3844-60 [2573698] Acta Crystallogr A. 1991 Mar 1;47 ( Pt 2):110-9 [2025413] Curr Opin Cell Biol. 1998 Aug;10(4):504-12 [9719872] J Biol Chem. 1998 Oct 16;273(42):27725-33 [9765310] Curr Biol. 1999 Mar 11;9(5):257-60 [10074456] Curr Biol. 1999 Mar 11;9(5):261-4 [10074457] J Biol Chem. 1999 May 21;274(21):14942-7 [10329695] J Protein Chem. 1999 Apr;18(3):277-90 [10395446] Nat Genet. 2005 Mar;37(3):289-94 [15731758] J Cell Biol. 2005 Apr 11;169(1):117-26 [15824135] Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13093-8 [16141317] Nature. 1991 May 30;351(6325):411-4 [1674590] Nature. 1991 Jun 13;351(6327):583-6 [1828536] J Cell Biol. 1993 Aug;122(3):553-63 [8101525] J Cell Biol. 1993 Aug;122(3):565-78 [8335685] J Biol Chem. 1993 Aug 15;268(23):17240-6 [8349610] Cell. 1994 Oct 21;79(2):199-209 [7954789] Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):816-20 [7846058] Nature. 1995 Mar 9;374(6518):186-90 [7877693] Nature. 1995 Mar 9;374(6518):190-2 [7877694] Nat Struct Biol. 1994 Nov;1(11):782-8 [7634088] J Cell Biol. 1995 Oct;131(1):69-80 [7559787] J Mol Biol. 1996 Jan 12;255(1):14-21 [8568861] EMBO J. 1996 Nov 15;15(22):6241-50 [8947047] Science. 1997 Apr 11;276(5310):259-63 [9092476] J Biol Chem. 1997 May 16;272(20):13419-25 [9148966] J Biol Chem. 1997 Oct 31;272(44):28030-5 [9346955] EMBO J. 1997 Nov 17;16(22):6676-83 [9362482] J Cell Biol. 1998 Apr 6;141(1):85-99 [9531550] Cell. 1998 Jun 12;93(6):1021-9 [9635431] Nat Cell Biol. 1999 May;1(1):33-9 [10559861] Neuron. 1999 Sep;24(1):143-54 [10677033] J Cell Biol. 2000 Sep 4;150(5):1137-48 [10974001] Neuron. 2000 Aug;27(2):301-12 [10985350] Biochemistry. 2000 Oct 10;39(40):12485-93 [11015230] Annu Rev Cell Dev Biol. 2000;16:483-519 [11031245] Ultramicroscopy. 2000 Dec;85(4):225-34 [11125866] Nature. 2001 Mar 8;410(6825):231-5 [11242086] Mol Biol Cell. 2001 Sep;12(9):2578-89 [11553700] Nat Cell Biol. 2001 Oct;3(10):922-6 [11584275] EMBO J. 2001 Nov 1;20(21):5813-21 [11689422] Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5175-80 [12682302] J Neurosci Methods. 2004 May 30;135(1-2):169-74 [15020101] Nat Rev Mol Cell Biol. 2004 Feb;5(2):133-47 [15040446] Mol Biol Cell. 2004 May;15(5):2243-52 [15004222] Nat Struct Mol Biol. 2004 Jun;11(6):574-5 [15133500] J Cell Biol. 2005 Sep 26;170(7):1021-7 [16186251] Nat Genet. 2005 Nov;37(11):1207-9 [16227997] Nat Cell Biol. 2006 May;8(5):477-84 [16622417] Nature. 2006 May 25;441(7092):528-31 [16648839] J Neurosci. 2007 Jan 10;27(2):379-90 [17215399] EMBO J. 2007 Jan 24;26(2):559-66 [17170701] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. AN - 68396079; 17938735 AB - Aberrant DNA methylation is common in carcinogenesis. The typical pattern appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1, inducing genomic hypomethylation, whereas increased expression of de novo DNMT3a or 3b causes gene-specific hypermethylation. During cadmium-induced malignant transformation, an unusual pattern of genomic hypermethylation occurred that we studied to provide insight into the roles of specific DNMTs in oncogenesis. Gene expression and DNA methylation were assessed in control and chronic cadmium-transformed prostate epithelial cells (CTPE) using reverse transcription-polymerase chain reaction (RT-PCR), Western blot analysis, methylation-specific PCR, and methyl acceptance assay. During the 10-weeks of cadmium exposure that induced malignant transformation, progressive increases in generalized DNMT enzymatic activity occurred that were associated with over-expression of DNMT3b without changes in DNMT1 expression. Increased DNMT3b expression preceded increased DNMT enzymatic activity. Procainamide, a specific DNMT1 inhibitor, reversed cadmium-induced genomic DNA hypermethylation. Reduced expression of the tumor suppressor genes, RASSF1A and p16, began about the time DNMT3b overexpression first occurred and progressively decreased thereafter. RASSF1A and p16 promoter regions were heavily methylated in CTPE cells, indicating silencing by hypermethylation, while the DNA demethylating agent, 5-aza-2'-deoxycytidine, reversed this silencing. DNMT1 inhibition only modestly increased RASSF1A and p16 expression in CTPE cells and did not completely reverse silencing. These data indicate that DNMT3b overexpression can result in generalized DNA hypermethylation and gene silencing but that DNMT1 is required to maintain these effects. The pattern of genomic DNA hypermethylation together with up-regulation of DNMT3b may provide a unique set of biomarkers to specifically identify cadmium-induced human prostate cancers. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Waterland, Robert A AU - Dill, Anna L AU - Webber, Mukta M AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1454 EP - 1459 VL - 115 IS - 10 SN - 0091-6765, 0091-6765 KW - Carcinogens, Environmental KW - 0 KW - Cadmium KW - 00BH33GNGH KW - DNA (Cytosine-5-)-Methyltransferase KW - EC 2.1.1.37 KW - DNA (cytosine-5-)-methyltransferase 1 KW - DNA methyltransferase 3B KW - Index Medicus KW - prostate KW - p16 KW - carcinogenesis KW - DNMT3b KW - cadmium KW - DNA methylation KW - RASSF1A KW - Gene Expression Profiling KW - Epithelial Cells -- drug effects KW - Genes, Tumor Suppressor -- drug effects KW - DNA (Cytosine-5-)-Methyltransferase -- drug effects KW - Cells, Cultured KW - Humans KW - Case-Control Studies KW - Up-Regulation KW - DNA (Cytosine-5-)-Methyltransferase -- metabolism KW - Male KW - Prostate -- drug effects KW - DNA Methylation -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Cadmium -- toxicity KW - Gene Expression Regulation -- drug effects KW - Carcinogens, Environmental -- toxicity KW - Prostate -- cytology KW - Cell Transformation, Neoplastic -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68396079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Tumor+suppressor+gene+inactivation+during+cadmium-induced+malignant+transformation+of+human+prostate+cells+correlates+with+overexpression+of+de+novo+DNA+methyltransferase.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BWaterland%2C+Robert+A%3BDill%2C+Anna+L%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2007-10-01&rft.volume=115&rft.issue=10&rft.spage=1454&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-26 N1 - Date created - 2007-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 2004 Sep 20;1704(2):87-102 [15363862] Clin Cancer Res. 2003 Oct 1;9(12):4415-22 [14555514] Biochem Biophys Res Commun. 1993 Jun 30;193(3):1184-90 [8323540] Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9821-6 [8790415] Adv Cancer Res. 1998;72:141-96 [9338076] Nat Genet. 1998 Jul;19(3):219-20 [9662389] Nucleic Acids Res. 1999 Jun 1;27(11):2291-8 [10325416] J Clin Oncol. 2004 Nov 15;22(22):4632-42 [15542813] Int J Cancer. 2005 Jan 20;113(3):440-5 [15455389] Clin Cancer Res. 2004 Dec 15;10(24):8472-8 [15623627] J Natl Cancer Inst. 2005 Jan 19;97(2):103-15 [15657340] Gynecol Oncol. 2005 Feb;96(2):531-8 [15661247] Int J Cancer. 2005 Apr 10;114(3):346-55 [15551354] Cancer Lett. 2005 Aug 8;226(1):77-84 [16004934] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Oral Oncol. 2006 Jan;42(1):5-13 [15978859] Cancer Res. 2006 Jan 15;66(2):729-35 [16424002] Endocr Relat Cancer. 2006 Jun;13(2):357-77 [16728568] Prostate. 2007 Feb 1;67(2):135-45 [17075824] Cell. 1999 Oct 29;99(3):247-57 [10555141] Cytogenet Cell Genet. 1999;86(3-4):333-4 [10575238] Nature. 2000 Apr 27;404(6781):1003-7 [10801130] J Environ Pathol Toxicol Oncol. 2000;19(3):307-18 [10983897] Cancer Res. 2001 Jan 15;61(2):455-8 [11212230] Nature. 2002 Apr 4;416(6880):552-6 [11932749] Mutat Res. 2003 Dec 10;533(1-2):107-20 [14643415] Cancer Res. 2002 Jun 15;62(12):3498-502 [12067994] Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10060-5 [12110732] J Biol Chem. 2002 Aug 2;277(31):28176-81 [12015329] Exp Cell Res. 2003 Jun 10;286(2):355-65 [12749863] Mol Cell Biol. 2003 Aug;23(16):5594-605 [12897133] Cancer Cells. 1991 Oct;3(10):383-90 [1777359] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) II. Clinical aspects. AN - 68392873; 17933685 AB - The simultaneous use of several drugs (polypharmacy) for the treatment of cancer, HIV, and other diseases and for multiple ailments of the elderly is a common practice in modern medicine. Co-administration of drugs may result in unwanted side effects. One reason for these side effects can be the altered function of transport proteins, especially of P-glycoprotein (Pgp), due to its simultaneous interaction with several drugs. We describe here some of the observed, unexpected side effects of polypharmacy in the clinic. We also describe intentional modulation of the function of Pgp that is introduced when facilitation of absorption of a drug through the intestines is needed and in cancer chemotherapy. In addition, we mention some methods of testing and ways by which doctors and patients can be alerted to potential side effects. JF - Drug discovery today AU - Aszalos, Adorjan AD - Laboratory of Cell Biology, 37 Convent Drive, Room 2108, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. aszalosa@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 838 EP - 843 VL - 12 IS - 19-20 SN - 1359-6446, 1359-6446 KW - ABCB1 protein, human KW - 0 KW - Antineoplastic Agents KW - P-Glycoprotein KW - P-Glycoproteins KW - Index Medicus KW - Animals KW - Humans KW - Antineoplastic Agents -- therapeutic use KW - P-Glycoprotein -- physiology KW - Drug Interactions KW - P-Glycoprotein -- genetics KW - Polypharmacy KW - Pharmacokinetics KW - P-Glycoprotein -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68392873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+discovery+today&rft.atitle=Drug-drug+interactions+affected+by+the+transporter+protein%2C+P-glycoprotein+%28ABCB1%2C+MDR1%29+II.+Clinical+aspects.&rft.au=Aszalos%2C+Adorjan&rft.aulast=Aszalos&rft.aufirst=Adorjan&rft.date=2007-10-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+discovery+today&rft.issn=13596446&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-17 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Some evidence of effects of environmental chemicals on the endocrine system in children. AN - 68379822; 17870664 AB - Pollutant chemicals that are widespread in the environment can affect endocrine function in laboratory experiments and in wildlife. Although human beings are commonly exposed to such pollutant chemicals, the exposures are generally low and clear effects on endocrine function from such exposures have been difficult to demonstrate. Human data including both exposure to the chemical agent and the endocrine outcome are reviewed here, including age at weaning, age at puberty, anogenital distance, and sex ratio at birth, and the strength of the evidence are discussed. Although endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real. JF - International journal of hygiene and environmental health AU - Rogan, Walter J AU - Ragan, N Beth AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. rogan@niehs.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 659 EP - 667 VL - 210 IS - 5 SN - 1438-4639, 1438-4639 KW - Endocrine Disruptors KW - 0 KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Breast Feeding KW - Puberty -- drug effects KW - Genitalia -- growth & development KW - Humans KW - Polychlorinated Biphenyls -- toxicity KW - Weaning KW - Child KW - Sex Ratio KW - Sexual Maturation -- drug effects KW - Genitalia -- drug effects KW - Lactation -- drug effects KW - Thyroid Gland -- drug effects KW - Muscle Hypotonia -- chemically induced KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Growth -- drug effects KW - Endocrine Disruptors -- toxicity KW - Endocrine System -- drug effects KW - Environmental Pollution -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68379822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+hygiene+and+environmental+health&rft.atitle=Some+evidence+of+effects+of+environmental+chemicals+on+the+endocrine+system+in+children.&rft.au=Rogan%2C+Walter+J%3BRagan%2C+N+Beth&rft.aulast=Rogan&rft.aufirst=Walter&rft.date=2007-10-01&rft.volume=210&rft.issue=5&rft.spage=659&rft.isbn=&rft.btitle=&rft.title=International+journal+of+hygiene+and+environmental+health&rft.issn=14384639&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-15 N1 - Date created - 2007-10-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Epidemiol. 2002 Feb 15;155(4):313-22 [11836195] Environ Health Perspect. 2001 Nov;109(11):1133-7 [11712998] Environ Health Perspect. 2002 Aug;110(8):771-6 [12153757] Environ Health Perspect. 2002 Sep;110(9):A503-4; author reply A504 [12269289] N Engl J Med. 2003 Apr 17;348(16):1527-36 [12700372] Environ Health Perspect. 2003 May;111(5):737-41 [12727603] Thyroid. 2003 Nov;13(11):1021-8 [14651786] Hum Reprod. 2004 Jul;19(7):1506-12 [15131079] Environ Health Perspect. 2004 Jul;112(10):A541-3 [15238295] N Engl J Med. 1978 Feb 2;298(5):243-8 [74014] Am J Pathol. 1980 Apr;99(1):125-42 [6767410] J Pediatr. 1981 Jan;98(1):47-51 [6256513] Pediatrics. 1980 Dec;66(6):918-20 [7454482] Arch Environ Health. 1984 Mar-Apr;39(2):85-9 [6721590] Eur J Pediatr. 1984 Sep;142(4):238-44 [6436027] J Pediatr. 1986 Aug;109(2):335-41 [3090217] Child Dev. 1987 Jun;58(3):829-41 [3608653] Am J Public Health. 1987 Oct;77(10):1294-7 [3115123] Int J Gynaecol Obstet. 1987;25 Suppl:47-55 [2892720] Am J Epidemiol. 1989 Jun;129(6):1187-200 [2729256] J Toxicol Environ Health. 1990 Oct;31(2):93-115 [2213927] Pediatr Res. 1994 Oct;36(4):468-73 [7816522] Am J Public Health. 1995 Apr;85(4):504-8 [7702113] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Lancet. 1996 Aug 10;348(9024):409 [8709758] Pediatrics. 1997 Apr;99(4):505-12 [9093289] Lancet. 1999 Jan 16;353(9148):206-7 [9923880] Sci Total Environ. 1999 Jan 12;225(1-2):81-90 [10028705] Environ Health Perspect. 1999 Oct;107(10):843-9 [10504153] Environ Health Perspect. 2004 Dec;112(17):1761-7 [15579424] Am J Epidemiol. 2005 Feb 1;161(3):289-96 [15671261] Pediatrics. 2005 Feb;115(2):e127-34 [15653789] Environ Health. 2004;3(1):8 [15363098] Environ Health Perspect. 2005 Aug;113(8):1039-45 [16079076] Environ Health Perspect. 2005 Aug;113(8):1056-61 [16079079] Paediatr Perinat Epidemiol. 2005 Sep;19(5):388-98 [16115291] Environ Health Perspect. 2005 Nov;113(11):1645-50 [16263525] Occup Environ Med. 2005 Dec;62(12):878-84 [16299097] Zhonghua Yu Fang Yi Xue Za Zhi. 2006 Mar;40(2):88-92 [16640903] Semin Reprod Med. 2006 Jul;24(3):156-67 [16804814] Environ Health Perspect. 2006 Aug;114(8):1276-82 [16882539] Am J Epidemiol. 2007 May 1;165(9):1015-22 [17272288] Epidemiology. 2000 May;11(3):249-54 [10784239] J Pediatr. 2000 May;136(5):599-605 [10802490] Lancet. 2000 May 27;355(9218):1858-63 [10866441] Environ Health Perspect. 2000 Sep;108(9):895-900 [11017896] Epidemiology. 2000 Nov;11(6):641-7 [11055623] Hum Reprod. 2001 May;16(5):1020-6 [11331654] J Natl Cancer Inst. 2001 May 16;93(10):768-76 [11353787] Lancet. 2002 Jul 13;360(9327):143-4 [12126828] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in apoptosis- and proliferation-related genes, ionizing radiation exposure, and risk of breast cancer among U.S. Radiologic Technologists. AN - 68374908; 17932347 AB - Although genes involved in apoptosis pathways and DNA repair pathways are both essential for maintaining genomic integrity, genetic variants in DNA repair have been thought to increase susceptibility to radiation carcinogenesis, but similar hypotheses have not generally been raised about apoptosis genes. For this reason, potential modification of the relationship between ionizing radiation exposure and breast cancer risk by polymorphic apoptosis gene variants have not been investigated among radiation-exposed women. In a case-control study of 859 cases and 1,083 controls within the U.S. Radiologic Technologists cohort, we assessed breast cancer risk with respect to 16 candidate variants in eight genes involved in apoptosis, inflammation, and proliferation. Using carefully reconstructed cumulative breast dose estimates from occupational and personal diagnostic ionizing radiation, we also investigated the joint effects of these polymorphisms on the risk of breast cancer. In multivariate analyses, we observed a significantly decreased risk of breast cancer associated with the homozygous minor allele of CASP8 D302H [rs1045485, odds ratio (OR), 0.3; 95% confidence interval (95% CI), 0.1-0.8]. We found a significantly increased breast cancer risk with increasing minor alleles for IL1A A114S (rs17561); heterozygote OR 1.2 (95% CI, 1.0-1.4) and homozygote OR 1.5 (95% CI, 1.1-2.0), P(trend) = 0.008. Assuming a dominant genetic model, IL1A A114S significantly modified the dose-response relationship between cumulative personal diagnostic radiation and breast cancer risk, adjusted for occupational dose (P(interaction) = 0.004). The U.S. Radiologic Technologists breast cancer study provided a unique opportunity to examine the joint effects of common genetic variation and ionizing radiation exposure to the breast using detailed occupational and personal diagnostic dose data. We found evidence of effect modification of the radiation and breast cancer dose-response relationship that should be confirmed in studies with more cases and controls and quantified radiation breast doses in the low-to-moderate range. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Sigurdson, Alice J AU - Bhatti, Parveen AU - Doody, Michele M AU - Hauptmann, Michael AU - Bowen, Laura AU - Simon, Steven L AU - Weinstock, Robert M AU - Linet, Martha S AU - Rosenstein, Marvin AU - Stovall, Marilyn AU - Alexander, Bruce H AU - Preston, Dale L AU - Struewing, Jeffrey P AU - Rajaraman, Preetha AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7092, MSC 7238, Bethesda, MD 20892-7238, USA. sigurdsa@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2000 EP - 2007 VL - 16 IS - 10 SN - 1055-9965, 1055-9965 KW - CASP8 and FADD-Like Apoptosis Regulating Protein KW - 0 KW - CFLAR protein, human KW - IL1A protein, human KW - Interleukin-1alpha KW - Index Medicus KW - Animals KW - Odds Ratio KW - Homozygote KW - Humans KW - Dose-Response Relationship, Radiation KW - Risk Assessment KW - Alleles KW - CASP8 and FADD-Like Apoptosis Regulating Protein -- genetics KW - Aged, 80 and over KW - Heterozygote KW - Cohort Studies KW - Case-Control Studies KW - Middle Aged KW - Polymorphism, Single Nucleotide -- genetics KW - Female KW - Gene Expression -- radiation effects KW - Interleukin-1alpha -- genetics KW - Breast Neoplasms -- genetics KW - Apoptosis -- genetics KW - Neoplasms, Radiation-Induced -- pathology KW - Apoptosis -- radiation effects KW - Neoplasms, Radiation-Induced -- genetics KW - Technology, Radiologic KW - Cell Division -- genetics KW - Cell Division -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68374908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Polymorphisms+in+apoptosis-+and+proliferation-related+genes%2C+ionizing+radiation+exposure%2C+and+risk+of+breast+cancer+among+U.S.+Radiologic+Technologists.&rft.au=Sigurdson%2C+Alice+J%3BBhatti%2C+Parveen%3BDoody%2C+Michele+M%3BHauptmann%2C+Michael%3BBowen%2C+Laura%3BSimon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BLinet%2C+Martha+S%3BRosenstein%2C+Marvin%3BStovall%2C+Marilyn%3BAlexander%2C+Bruce+H%3BPreston%2C+Dale+L%3BStruewing%2C+Jeffrey+P%3BRajaraman%2C+Preetha&rft.aulast=Sigurdson&rft.aufirst=Alice&rft.date=2007-10-01&rft.volume=16&rft.issue=10&rft.spage=2000&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-25 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical pharmacology of antifungal agents in pediatric patients. AN - 68371159; 17931084 AB - Invasive fungal infections have emerged as important causes of morbidity and mortality in profoundly immunocompromised children including cancer, transplant and intensive care unit patients. Present treatment strategies for these infections are limited by toxicity, drug interactions and expense. In order to overcome these limitations, new antifungal compounds are being developed, which may improve the therapeutic armamentarium for prevention and treatment of invasive mycoses in high-risk children. This article summarizes the clinical pharmacology of established and newly developed antifungal agents, including new triazoles and echinocandins in pediatric age groups. JF - Expert opinion on pharmacotherapy AU - Chiou, Christine C AU - Walsh, Thomas J AU - Groll, Andreas H AD - National Cancer Institute, Immunocompromised Host Section, Pediatric Oncology Branch, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2465 EP - 2489 VL - 8 IS - 15 KW - Antifungal Agents KW - 0 KW - Index Medicus KW - Age Factors KW - Chemistry, Pharmaceutical KW - Mycoses -- metabolism KW - Humans KW - Mycoses -- drug therapy KW - Child KW - Pharmacology, Clinical -- trends KW - Antifungal Agents -- pharmacokinetics KW - Pharmacology, Clinical -- methods KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68371159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Expert+opinion+on+pharmacotherapy&rft.atitle=Clinical+pharmacology+of+antifungal+agents+in+pediatric+patients.&rft.au=Chiou%2C+Christine+C%3BWalsh%2C+Thomas+J%3BGroll%2C+Andreas+H&rft.aulast=Chiou&rft.aufirst=Christine&rft.date=2007-10-01&rft.volume=8&rft.issue=15&rft.spage=2465&rft.isbn=&rft.btitle=&rft.title=Expert+opinion+on+pharmacotherapy&rft.issn=1744-7666&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-06 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sex-gender differences in drug abuse: a shift in the burden of proof? AN - 68362898; 17924775 AB - In the early years of NIDA-supported drug abuse research, much of the research on women was treatment related and conducted out of concern for their pregnancy status. Since then, drug abuse research on women has expanded to include females of all ages, including infants, children, and adolescents, both human and animal. This expansion has also extended to the study of male-female differences. In the early years of the expansion, National Institutes of Health study sections demanded a heavy burden of proof from drug abuse researchers who proposed to study male-female differences. The need for such research appeared not to have face validity. The tide has now changed with the growing body of literature attesting to its scientific and clinical validity. This change is often reflected in concerns expressed in study sections reviewing drug abuse grant applications that an applicant does not propose to analyze the data for sex-gender differences when in fact the literature suggests that such differences would be observed. Although the change has been slow, it suggests that the burden of proof is shifting from having to defend why sex-gender differences should be studied to having to defend why they should not. (c) 2007 APA JF - Experimental and clinical psychopharmacology AU - Wetherington, Cora Lee AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9555, USA. wetherington@nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 411 EP - 417 VL - 15 IS - 5 SN - 1064-1297, 1064-1297 KW - Gonadal Steroid Hormones KW - 0 KW - Index Medicus KW - United States KW - Animals KW - Sex Factors KW - Sex Characteristics KW - Humans KW - National Institute on Drug Abuse (U.S.) KW - Menstrual Cycle -- metabolism KW - Research Subjects KW - Gonadal Steroid Hormones -- physiology KW - Male KW - Female KW - Substance-Related Disorders -- physiopathology KW - Substance-Related Disorders -- therapy KW - Biomedical Research -- methods KW - Gender Identity KW - Patient Selection KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68362898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+clinical+psychopharmacology&rft.atitle=Sex-gender+differences+in+drug+abuse%3A+a+shift+in+the+burden+of+proof%3F&rft.au=Wetherington%2C+Cora+Lee&rft.aulast=Wetherington&rft.aufirst=Cora&rft.date=2007-10-01&rft.volume=15&rft.issue=5&rft.spage=411&rft.isbn=&rft.btitle=&rft.title=Experimental+and+clinical+psychopharmacology&rft.issn=10641297&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. AN - 68360569; 17765930 AB - Administration of serotonin-enhancing drugs induces a distinctive behavioral syndrome in rodents. We previously reported that mice with a targeted disruption of the serotonin transporter (SERT) display some of these behaviors spontaneously, in the absence of drug. In the current studies, we assessed the drug-induced serotonin syndrome in SERT wildtype (+/+), heterozygous (+/-) and knockout (-/-) mice. In SERT -/- mice, the monoamine oxidase inhibitor (MAOI) tranylcypromine (1mg/kg) or the serotonin precursor 5-hydroxy-L-tryptophan (5-HTP; 80 mg/kg) led to markedly exaggerated serotonin syndrome behaviors relative to SERT +/+ mice, with an intermediate phenotype in SERT +/- mice. SERT +/+ mice developed significant serotonin syndrome behaviors only with the combination of the MAO-A/B inhibitor tranylcypromine (0.5 or 1 mg/kg) or the MAO-A-selective inhibitor clorgyline (1.2 mg/kg) plus 5-HTP. In evaluations of underlying mechanisms, pretreatment with the Htr1a receptor antagonist WAY 100635 (1 mg/kg), but not the Htr7 antagonist SB 269970 (3 mg/kg) or the Htr2a antagonist MDL 11,939 (5 mg/kg), markedly decreased the exaggerated 5-HTP-induced behaviors in SERT -/- mice. Subsequent experiments showed that the Htr1a agonist 8-OH-DPAT (1 or 2 mg/kg) elicited serotonin syndrome behaviors in a dose-dependent manner, blocked by WAY 100635 (1 mg/kg), in mice of all three genotypes, confirming the role of Htr1a receptors. The current data document markedly enhanced behavioral sensitivity to serotonin-enhancing drugs in SERT-deficient mice. These studies also show that the exaggerated behavioral responses observed in SERT +/- and -/- mice are mediated by postsynaptic Htr1a receptors, and suggest intact postsynaptic Htr1a function in SERT -/- mice. JF - Neuropharmacology AU - Fox, Meredith A AU - Jensen, Catherine L AU - Gallagher, Pamela S AU - Murphy, Dennis L AD - Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. mfox@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 643 EP - 656 VL - 53 IS - 5 SN - 0028-3908, 0028-3908 KW - Monoamine Oxidase Inhibitors KW - 0 KW - Piperazines KW - Piperidines KW - Pyridines KW - Receptors, Serotonin KW - Serotonin Antagonists KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin Receptor Agonists KW - alpha-phenyl-1-(2-phenylethyl)-4-piperidinemethanol KW - 107703-78-6 KW - Tranylcypromine KW - 3E3V44J4Z9 KW - N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide KW - 71IH826FEG KW - 8-Hydroxy-2-(di-n-propylamino)tetralin KW - 78950-78-4 KW - 5-Hydroxytryptophan KW - C1LJO185Q9 KW - Index Medicus KW - Animals KW - Serotonin Antagonists -- pharmacology KW - Dose-Response Relationship, Drug KW - Polymorphism, Genetic -- genetics KW - Mice KW - Piperazines -- pharmacology KW - Monoamine Oxidase Inhibitors -- pharmacology KW - Mice, Knockout KW - Serotonin Syndrome -- psychology KW - Piperidines -- pharmacology KW - Behavior, Animal -- drug effects KW - Tranylcypromine -- pharmacology KW - 8-Hydroxy-2-(di-n-propylamino)tetralin -- pharmacology KW - 5-Hydroxytryptophan -- pharmacology KW - Mice, Inbred C57BL KW - Pyridines -- pharmacology KW - Female KW - Serotonin Receptor Agonists -- pharmacology KW - Receptors, Serotonin -- drug effects KW - Serotonin Plasma Membrane Transport Proteins -- deficiency KW - Serotonin Plasma Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68360569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Receptor+mediation+of+exaggerated+responses+to+serotonin-enhancing+drugs+in+serotonin+transporter+%28SERT%29-deficient+mice.&rft.au=Fox%2C+Meredith+A%3BJensen%2C+Catherine+L%3BGallagher%2C+Pamela+S%3BMurphy%2C+Dennis+L&rft.aulast=Fox&rft.aufirst=Meredith&rft.date=2007-10-01&rft.volume=53&rft.issue=5&rft.spage=643&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-14 N1 - Date created - 2007-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histological and proteomic analysis of reversible H-RasV12G expression in transgenic mouse skin. AN - 68350744; 17551062 AB - We have used a two-transgene tetracycline system to reversibly express oncogenic H-Ras(V12G) in mouse skin and primary keratinocytes culture using the bovine keratin 5 promoter. Induction of H-Ras(V12G) expression in skin at 30 days after birth causes epidermal basal cell hyperplasia, an eruption of keratinous cysts and loss of hair follicles by 3 weeks. Subsequent H-Ras(V12G) de-induction for 3 days results in massive apoptosis in the non-H-Ras(V12G)-expressing stroma as well as in the suprabasal cells of the epidermis. Several procaspases such as CASP3, 1alpha, 5 and 12 disappeared, whereas the pro-apoptotic proteins AIF, Bax and Fas ligand were induced in H-Ras(V12G) de-induction skin. This process is followed by a wave of cell division at 14 days as hair follicles regrew, returning to near normal histology and skin appearance by 30 days. Using Kinetworkstrade mark multi-immunoblotting screens, the phosphorylation status of 37 proteins and expression levels of 75 protein kinases in the skin were determined in three samples: (i) wild-type skin, (ii) hyperplastic H-Ras(V12G)-expressing skin and (iii) skin where H-Ras(V12G) expression was suppressed for 7 days. Following H-Ras(V12G) induction, 16 kinases were increased over 2-fold, and 2 kinases were reduced over 50%. This included increased phosphorylation of both known downstream H-Ras(V12G) targets and unknown H-Ras(V12G) targets. After H-Ras(V12G) suppression, many but not all protein changes were reversed. These results from skin and primary keratinocytes are organized to reflect the molecular events that cause the histological changes observed. These proteomic changes identify markers that may mediate the oncogenic addiction paradigm. JF - Carcinogenesis AU - Oh, Won-Jun AU - Rishi, Vikas AU - Pelech, Steven AU - Vinson, Charles AD - Laboratory of Metabolism, National Cancer Institute, Centre for Cancer Research, National Institutes of Health, Building 37, Room 3128, Bethesda, MD 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2244 EP - 2252 VL - 28 IS - 10 KW - DNA Primers KW - 0 KW - Phosphoproteins KW - Proteome KW - Protein Kinases KW - EC 2.7.- KW - Index Medicus KW - Protein Kinases -- metabolism KW - Polymerase Chain Reaction KW - Animals KW - Apoptosis KW - Mice KW - Mice, Transgenic KW - Phosphoproteins -- metabolism KW - Cell Division KW - Genes, ras KW - Skin Physiological Phenomena KW - Skin -- pathology KW - Skin -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68350744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Histological+and+proteomic+analysis+of+reversible+H-RasV12G+expression+in+transgenic+mouse+skin.&rft.au=Oh%2C+Won-Jun%3BRishi%2C+Vikas%3BPelech%2C+Steven%3BVinson%2C+Charles&rft.aulast=Oh&rft.aufirst=Won-Jun&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=2244&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=1460-2180&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-10-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane. AN - 68341987; 17892485 AB - Lipooligosaccharide (LOS), a major component of the outer membrane of Moraxella catarrhalis, consists of two major moieties: a lipid A and a core oligosaccharide (OS). The core OS can be dissected into a linker and three OS chains. To gain an insight into the biological activities of the LOS molecules of M. catarrhalis, we used a random transposon mutagenesis approach with an LOS specific monoclonal antibody to construct a serotype A O35Elgt3 LOS mutant. MALDI-TOF-MS of de-O-acylated LOS from the mutant and glycosyl composition, linkage, and NMR analysis of its OS indicated that the LOS contained a truncated core OS and consisted of a Glc-Kdo(2) (linker)-lipid A structure. Phenotypic analysis revealed that the mutant was similar to the wild-type strain in its growth rate, toxicity and susceptibility to hydrophobic reagents. However, the mutant was sensitive to bactericidal activity of normal human serum and had a reduced adherence to human epithelial cells. These data, combined with our previous data obtained from mutants which contained only lipid A or lacked LOS, suggest that the complete OS chain moiety of the LOS is important for serum resistance and adherence to epithelial cells, whereas the linker moiety is critical for maintenance of the outer membrane integrity and stability to preserve normal cell growth. Both the lipid A and linker moieties contribute to the LOS toxicity. JF - The FEBS journal AU - Peng, Daxin AU - Hu, Wei-Gang AU - Choudhury, Biswa P AU - Muszyński, Artur AU - Carlson, Russell W AU - Gu, Xin-Xing AD - Vaccine Research Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 5350 EP - 5359 VL - 274 IS - 20 SN - 1742-464X, 1742-464X KW - Antibodies, Bacterial KW - 0 KW - Antibodies, Monoclonal KW - Antigens, Bacterial KW - Lipid A KW - Lipopolysaccharides KW - lipid-linked oligosaccharides KW - Index Medicus KW - Animals KW - HeLa Cells KW - Humans KW - Cell Membrane Structures -- metabolism KW - Antibodies, Bacterial -- immunology KW - Mice KW - Antigens, Bacterial -- immunology KW - Antigens, Bacterial -- pharmacology KW - Antibodies, Monoclonal -- pharmacology KW - Mice, Inbred BALB C KW - Antigens, Bacterial -- blood KW - Bacterial Adhesion -- immunology KW - Mutagenesis KW - Antibodies, Monoclonal -- immunology KW - Antibodies, Bacterial -- pharmacology KW - Adult KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Molecular Sequence Data KW - Nasal Lavage Fluid -- microbiology KW - Female KW - Cell Adhesion -- physiology KW - Lipopolysaccharides -- metabolism KW - Nasopharynx -- microbiology KW - Lipid A -- chemistry KW - Moraxellaceae Infections -- metabolism KW - Lipopolysaccharides -- chemistry KW - Lipid A -- immunology KW - Moraxella (Branhamella) catarrhalis -- pathogenicity KW - Moraxellaceae Infections -- immunology KW - Lipopolysaccharides -- immunology KW - Lipid A -- metabolism KW - Moraxellaceae Infections -- pathology KW - Moraxella (Branhamella) catarrhalis -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68341987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+FEBS+journal&rft.atitle=Role+of+different+moieties+from+the+lipooligosaccharide+molecule+in+biological+activities+of+the+Moraxella+catarrhalis+outer+membrane.&rft.au=Peng%2C+Daxin%3BHu%2C+Wei-Gang%3BChoudhury%2C+Biswa+P%3BMuszy%C5%84ski%2C+Artur%3BCarlson%2C+Russell+W%3BGu%2C+Xin-Xing&rft.aulast=Peng&rft.aufirst=Daxin&rft.date=2007-10-01&rft.volume=274&rft.issue=20&rft.spage=5350&rft.isbn=&rft.btitle=&rft.title=The+FEBS+journal&rft.issn=1742464X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-10-03 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - DQ208195; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Follow-up of children exposed in utero to 17 alpha-hydroxyprogesterone caproate compared with placebo. AN - 68339865; 17906021 AB - To assess whether there are evident adverse effects of 17 alpha-hydroxyprogesterone caproate after in utero exposure. This study evaluated surviving children of mothers who participated in a multicenter placebo-controlled trial of weekly intramuscular 17 alpha-hydroxyprogesterone caproate, with a 2:1 allocation to 17 alpha-hydroxyprogesterone caproate and placebo, respectively. The guardian was interviewed about the child's general health. Children underwent a physical examination and developmental screen with the Ages and Stages Questionnaire. Gender-specific roles were assessed with the Preschool Activities Inventory. Of 348 eligible surviving children, 278 (80%) were available for evaluation (194 in the 17 alpha-hydroxyprogesterone caproate group and 84 in the placebo group). The mean age at follow-up was 48 months. No significant differences were seen in health status or physical examination, including genital anomalies, between 17 alpha-hydroxyprogesterone caproate and placebo children. Scores for gender-specific roles (Preschool Activities Inventory) were within the normal range and similar between 17 alpha-hydroxyprogesterone caproate and placebo groups. 17 alpha-hydroxyprogesterone caproate seems to be safe for the fetus when administered in the second and third trimesters. JF - Obstetrics and gynecology AU - Northen, Allison T AU - Norman, Gwendolyn S AU - Anderson, Kristine AU - Moseley, Lisa AU - Divito, Michelle AU - Cotroneo, Margaret AU - Swain, Melissa AU - Bousleiman, Sabine AU - Johnson, Francee AU - Dorman, Karen AU - Milluzzi, Cynthia AU - Tillinghast, Jo-Ann AU - Kerr, Marcia AU - Mallett, Gail AU - Thom, Elizabeth AU - Pagliaro, Susan AU - Anderson, Garland D AU - National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network AD - Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, Alabama 35294-0024, USA. anorthen@uab.edu ; National Institute of Child Health and Human Development (NICHD) Maternal-Fetal Medicine Units (MFMU) Network Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 865 EP - 872 VL - 110 IS - 4 SN - 0029-7844, 0029-7844 KW - Hydroxyprogesterones KW - 0 KW - Progestins KW - 17-alpha-hydroxy-progesterone caproate KW - 276F2O42F5 KW - Abridged Index Medicus KW - Index Medicus KW - Pregnancy Trimester, Second KW - Pregnancy Trimester, Third KW - Humans KW - Infant, Newborn KW - Follow-Up Studies KW - Female KW - Pregnancy KW - Child, Preschool KW - Progestins -- adverse effects KW - Hydroxyprogesterones -- adverse effects KW - Child Development -- drug effects KW - Nervous System -- growth & development KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68339865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obstetrics+and+gynecology&rft.atitle=Follow-up+of+children+exposed+in+utero+to+17+alpha-hydroxyprogesterone+caproate+compared+with+placebo.&rft.au=Northen%2C+Allison+T%3BNorman%2C+Gwendolyn+S%3BAnderson%2C+Kristine%3BMoseley%2C+Lisa%3BDivito%2C+Michelle%3BCotroneo%2C+Margaret%3BSwain%2C+Melissa%3BBousleiman%2C+Sabine%3BJohnson%2C+Francee%3BDorman%2C+Karen%3BMilluzzi%2C+Cynthia%3BTillinghast%2C+Jo-Ann%3BKerr%2C+Marcia%3BMallett%2C+Gail%3BThom%2C+Elizabeth%3BPagliaro%2C+Susan%3BAnderson%2C+Garland+D%3BNational+Institute+of+Child+Health+and+Human+Development+%28NICHD%29+Maternal-Fetal+Medicine+Units+%28MFMU%29+Network&rft.aulast=Northen&rft.aufirst=Allison&rft.date=2007-10-01&rft.volume=110&rft.issue=4&rft.spage=865&rft.isbn=&rft.btitle=&rft.title=Obstetrics+and+gynecology&rft.issn=00297844&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-20 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Traffic exposure and lung function in adults: the Atherosclerosis Risk in Communities study. AN - 68338624; 17442705 AB - Traffic exposure is a major contributor to ambient air pollution for people living close to busy roads. The relationship between traffic exposure and lung function remains inconclusive in adults. A cross-sectional study was conducted to investigate the association between traffic exposure and lung function in the Atherosclerosis Risk in Communities (ARIC) study, a community based cohort of 15 792 middle aged men and women. Traffic density and distance to major roads were used as measures of traffic exposure. After controlling for potential confounders including demographic factors, personal and neighbourhood level socioeconomic characteristics, cigarette smoking and background air pollution, higher traffic density was significantly associated with lower forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) in women. Relative to the lowest quartile of traffic density, the adjusted differences across increasing quartiles were 5.1, -15.4 and -21.5 ml for FEV1 (p value of linear trend across the quartiles = 0.041) and 1.2, -23.4 and -34.8 ml for FVC (p trend = 0.010). Using distance from major roads as a simpler index of traffic related air pollution exposure, the FEV1 was -15.7 ml (95% CI -34.4 to 2.9) lower and the FVC was -24.2 ml (95% CI -46.2 to -2.3) lower for women living within 150 m compared with subjects living further away. There was no significant effect of traffic density or distance to major roads on lung function in men. The FEV1/FVC ratio was not significantly associated with traffic exposure in either men or women. This is the largest published study of traffic exposure and pulmonary function in adults to date. These results add to growing evidence that chronic exposure to traffic related air pollution may adversely affect respiratory health. JF - Thorax AU - Kan, Haidong AU - Heiss, Gerardo AU - Rose, Kathryn M AU - Whitsel, Eric AU - Lurmann, Fred AU - London, Stephanie J AD - National Institute of Environmental Health Sciences, P O Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 873 EP - 879 VL - 62 IS - 10 SN - 0040-6376, 0040-6376 KW - Air Pollutants KW - 0 KW - Vehicle Emissions KW - Index Medicus KW - Cross-Sectional Studies KW - Risk Factors KW - Humans KW - Cohort Studies KW - Vital Capacity -- physiology KW - Middle Aged KW - Forced Expiratory Volume -- physiology KW - Male KW - Female KW - Lung Diseases -- etiology KW - Vehicle Emissions -- toxicity KW - Lung Diseases -- physiopathology KW - Air Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68338624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thorax&rft.atitle=Traffic+exposure+and+lung+function+in+adults%3A+the+Atherosclerosis+Risk+in+Communities+study.&rft.au=Kan%2C+Haidong%3BHeiss%2C+Gerardo%3BRose%2C+Kathryn+M%3BWhitsel%2C+Eric%3BLurmann%2C+Fred%3BLondon%2C+Stephanie+J&rft.aulast=Kan&rft.aufirst=Haidong&rft.date=2007-10-01&rft.volume=62&rft.issue=10&rft.spage=873&rft.isbn=&rft.btitle=&rft.title=Thorax&rft.issn=00406376&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-07 N1 - Date created - 2007-10-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 1997 Jan;155(1):122-9 [9001300] Eur Heart J. 2006 Nov;27(22):2696-702 [17003049] Environ Res. 1997;74(2):122-32 [9339225] Am J Respir Crit Care Med. 1998 Jul;158(1):289-98 [9655742] Am J Epidemiol. 1998 Sep 1;148(5):475-86 [9737560] Arch Environ Health. 1999 Jan-Feb;54(1):26-33 [10025413] Environ Health Perspect. 1998 Feb;106(2):93-9 [9435151] Sci Total Environ. 2005 Feb 15;338(3):243-51 [15713332] Int Arch Occup Environ Health. 2005 Mar;78(2):164-9 [15726395] Environ Res. 2005 Jun;98(2):240-9 [15820731] Thorax. 1999 Dec;54(12):1070-4 [10567625] Chest. 2000 Mar;117(3):764-72 [10713004] Am J Respir Crit Care Med. 2001 Feb;163(2):356-61 [11179106] Int J Hyg Environ Health. 2001 Mar;203(3):235-44 [11279820] N Engl J Med. 2001 Jul 12;345(2):134-6 [11450663] Eur Respir J. 2001 May;17(5):1024-33 [11488305] Am J Respir Crit Care Med. 2001 Dec 15;164(12):2177-80 [11751183] Arch Environ Health. 2001 Sep-Oct;56(5):467-70 [11777030] J Expo Anal Environ Epidemiol. 2001 Nov-Dec;11(6):459-69 [11791163] Eur Respir J. 2002 Apr;19(4):690-8 [11998999] Environ Health Perspect. 2002 Aug;110(8):765-70 [12153756] Ann Epidemiol. 2002 Oct;12(7):482-7 [12377426] Lancet. 2002 Oct 19;360(9341):1203-9 [12401246] Environ Health Perspect. 2003 Feb;111(2):207-16 [12573907] Epidemiology. 2003 Mar;14(2):228-39 [12606891] Eur Respir J. 2003 Jun;21(6):1017-23 [12797498] Pediatr Pulmonol. 2003 Aug;36(2):148-61 [12833495] Epidemiology. 2003 Nov;14(6):728-36 [14569190] Occup Environ Med. 2004 Apr;61(4):350-7 [15031394] Chest. 2004 Apr;125(4):1394-9 [15078751] Arch Environ Health. 1983 Nov-Dec;38(6):334-40 [6198975] Am J Ind Med. 1988;14(1):25-36 [2457311] Am J Epidemiol. 1989 Apr;129(4):687-702 [2646917] Environ Res. 1989 Dec;50(2):309-21 [2583077] Arch Environ Health. 1991 May-Jun;46(3):135-44 [2039267] Am Rev Respir Dis. 1992 Oct;146(4):888-94 [1416415] Eur Respir J. 1994 Mar;7(3):477-83 [8013605] Arch Environ Health. 1995 May-Jun;50(3):207-13 [7542442] Environ Health Perspect. 1996 May;104(5):506-14 [8743438] Int J Epidemiol. 1995 Dec;24(6):1147-53 [8824856] Occup Environ Med. 2005 Jun;62(6):376-80 [15901884] Thorax. 2005 Jun;60(6):467-73 [15923246] Respir Res. 2005;6:45 [15918902] J Allergy Clin Immunol. 2005 Aug;116(2):279-84 [16083780] Epidemiology. 2005 Nov;16(6):737-43 [16222162] Lancet. 2007 Feb 17;369(9561):571-7 [17307103] Epidemiology. 1997 May;8(3):298-303 [9115026] Respir Res. 2005;6:152 [16372913] Environ Health Perspect. 2006 May;114(5):766-72 [16675435] Comment In: Thorax. 2007 Oct;62(10):837-8 [17909186] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk assessment to guide the prevention of cervical cancer. AN - 68337330; 17904958 AB - Advances in screening and diagnosis make it increasingly possible to prevent cervical cancer. However, if misused or poorly understood, these new tools will only increase costs and potentially harm patients without benefit. As a framework for standardized care that maximizes patient safety and well-being, we propose that a risk model be adopted to guide clinical management now and in the future. The model would use thresholds of increasing risk for cervical precancer and treatable cancer to guide clinical decision making for screening intensity, diagnostic evaluation, or treatment. Experts would decide on these risk thresholds and stratum based on the patient risk to benefit, independent of current (eg, cytology, carcinogenic HPV testing, and colposcopy) and future methods of measuring risk. A risk management model for cervical cancer prevention, based on appropriate clinical actions that correspond to risk stratum, can result in better allocation of resources to and increased safety for women at the greatest risk and increased well-being for women at the lowest risk. JF - American journal of obstetrics and gynecology AU - Castle, Philip E AU - Sideri, Mario AU - Jeronimo, Jose AU - Solomon, Diane AU - Schiffman, Mark AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 356.e1 EP - 6 VL - 197 IS - 4 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Risk Management KW - Models, Statistical KW - Female KW - Risk Assessment KW - Papillomaviridae -- growth & development KW - Papillomavirus Infections -- pathology KW - Uterine Cervical Neoplasms -- prevention & control KW - Cervical Intraepithelial Neoplasia -- pathology KW - Cervical Intraepithelial Neoplasia -- prevention & control KW - Precancerous Conditions -- prevention & control KW - Papillomavirus Infections -- virology KW - Cervical Intraepithelial Neoplasia -- virology KW - Uterine Cervical Neoplasms -- pathology KW - Precancerous Conditions -- virology KW - Precancerous Conditions -- pathology KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68337330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Risk+assessment+to+guide+the+prevention+of+cervical+cancer.&rft.au=Castle%2C+Philip+E%3BSideri%2C+Mario%3BJeronimo%2C+Jose%3BSolomon%2C+Diane%3BSchiffman%2C+Mark&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2007-10-01&rft.volume=197&rft.issue=4&rft.spage=356.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-09 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Low intensity permanent magnets in the treatment of chronic lumbar radicular pain. AN - 68330203; 17618081 AB - We assessed the pain-relieving efficacy of static magnetic fields produced by 200 Gauss (G) magnets compared with 50G magnets in a double-blind, randomized, two-phase crossover study in patients with chronic lumbar radicular pain. The surface field strengths of the magnets were 200 and 50G. Phase I included four random periods of two-week duration: two periods with 200G, one period with 50G, and one period of "no treatment." The magnets were positioned either vertically or horizontally in standard lumbosacral elastic corsets. Phase II consisted of two five-week periods with the most effective magnet from Phase I and its corresponding 50 or 200G device. The primary outcome was average daily leg pain score (0-10 scale) in each period of Phase II. Thirty-eight of 40 randomized patients completed Phase I, and 28 of 31 Phase II participants completed the study. In Phase I, pain scores did not differ significantly between 200 and 50G magnets. Phase II average leg pain scores tended to be lower with 200 vs. 50G magnets (3.2+/-2.1 for 200G vs. 3.9+/-2.2 for 50G magnets [P=0.08]) after excluding one unblinded patient. The relative treatment effect of the 200G magnets appeared to increase throughout the five-week period. Although these data cannot rule out a chance effect, the positive trends suggest that larger, longer-duration, sham-controlled trials with 200G magnets be considered in patients with chronic lumbar radicular pain. JF - Journal of pain and symptom management AU - Khoromi, Suzan AU - Blackman, Marc R AU - Kingman, Albert AU - Patsalides, Athos AU - Matheny, Leigh Ann AU - Adams, Sandra AU - Pilla, Arthur A AU - Max, Mitchell B AD - National Center for Complementary and Alternative Medicine, National Institute of Mental Health, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20814, USA. khoromisu@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 434 EP - 445 VL - 34 IS - 4 SN - 0885-3924, 0885-3924 KW - Index Medicus KW - Radiation Dosage KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Chronic Disease KW - Adolescent KW - Male KW - Female KW - Lumbar Vertebrae KW - Radiculopathy -- diagnosis KW - Sciatica -- diagnosis KW - Radiculopathy -- therapy KW - Low Back Pain -- prevention & control KW - Sciatica -- prevention & control KW - Magnetics -- therapeutic use KW - Low Back Pain -- diagnosis KW - Pain Measurement -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68330203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pain+and+symptom+management&rft.atitle=Low+intensity+permanent+magnets+in+the+treatment+of+chronic+lumbar+radicular+pain.&rft.au=Khoromi%2C+Suzan%3BBlackman%2C+Marc+R%3BKingman%2C+Albert%3BPatsalides%2C+Athos%3BMatheny%2C+Leigh+Ann%3BAdams%2C+Sandra%3BPilla%2C+Arthur+A%3BMax%2C+Mitchell+B&rft.aulast=Khoromi&rft.aufirst=Suzan&rft.date=2007-10-01&rft.volume=34&rft.issue=4&rft.spage=434&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+and+symptom+management&rft.issn=08853924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-26 N1 - Date created - 2007-10-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine lesion-induced changes in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats. AN - 68320551; 17897398 AB - Dysfunctional activity in the subthalamic nucleus (STN) is thought to underlie movement deficits of patients with Parkinson's disease. Alterations in STN firing patterns are also evident in the anesthetized rat model of Parkinson's disease, where studies show that loss of striatal dopamine and concomitant changes in the indirect pathway are associated with bursty and oscillatory firing patterns in STN output. However, the extent to which alterations in cortical activity contribute to changes in STN activity is unclear. As pyramidal neurons in the cingulate cortex project directly to the STN, cingulate output was assessed after dopamine lesion by simultaneously recording single-unit and local field potential (LFP) activities in STN and anterior cingulate cortex in control, dopamine-lesioned and non-lesioned hemispheres of urethane-anesthetized rats. Correlated oscillations were observed in cross-correlograms of spike trains from STN and cingulate layer V neurons with broad waveforms indicative of pyramidal neurons. One-2 weeks after dopamine cell lesion, firing rate, incidence of bursty and 0.3-2.5 Hz oscillatory activity of neurons and LFP power in the STN all increased significantly. In contrast, firing rate, incidence of bursty and 0.3-2.5 Hz oscillatory activity of cingulate layer V putative pyramidal neurons and power in cingulate LFPs did not differ significantly between dopamine-lesioned, non-lesioned or control hemispheres, despite significant loss of dopamine in the lesioned cingulate cortex. Data show that alterations in STN activity in the dopamine-lesioned hemisphere are not associated with alterations in neuronal activity in layer V of the anterior cingulate cortex in anesthetized rats. JF - The European journal of neuroscience AU - Parr-Brownlie, Louise C AU - Poloskey, Stacey L AU - Flanagan, Kalynda K AU - Eisenhofer, Graeme AU - Bergstrom, Debra A AU - Walters, Judith R AD - Neurophysiological Pharmacology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 35 Convent Drive, Building 35 Room 1C 905, Bethesda, MD 20892-3702, USA. parrbl@ninds.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1925 EP - 1939 VL - 26 IS - 7 SN - 0953-816X, 0953-816X KW - Sympatholytics KW - 0 KW - Oxidopamine KW - 8HW4YBZ748 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Sympatholytics -- toxicity KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Anesthesia KW - Oxidopamine -- toxicity KW - Medial Forebrain Bundle -- physiology KW - Medial Forebrain Bundle -- injuries KW - Evoked Potentials -- physiology KW - Fourier Analysis KW - Male KW - Functional Laterality KW - Subthalamic Nucleus -- drug effects KW - Pyramidal Cells -- drug effects KW - Action Potentials -- physiology KW - Pyramidal Cells -- physiology KW - Subthalamic Nucleus -- injuries KW - Gyrus Cinguli -- cytology KW - Dopamine -- metabolism KW - Action Potentials -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68320551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Dopamine+lesion-induced+changes+in+subthalamic+nucleus+activity+are+not+associated+with+alterations+in+firing+rate+or+pattern+in+layer+V+neurons+of+the+anterior+cingulate+cortex+in+anesthetized+rats.&rft.au=Parr-Brownlie%2C+Louise+C%3BPoloskey%2C+Stacey+L%3BFlanagan%2C+Kalynda+K%3BEisenhofer%2C+Graeme%3BBergstrom%2C+Debra+A%3BWalters%2C+Judith+R&rft.aulast=Parr-Brownlie&rft.aufirst=Louise&rft.date=2007-10-01&rft.volume=26&rft.issue=7&rft.spage=1925&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. AN - 68318553; 17898344 AB - Suicidal ideation is an uncommon symptom than can emerge during antidepressant treatment. The biological basis of treatment-emergent suicidal ideation is unknown. Genetic markers may shed light on the causes of treatment-emergent suicidal ideation and help identify individuals at high risk who may benefit from closer monitoring, alternative treatments, or specialty care. A clinically representative cohort of outpatients with major depressive disorder who enrolled in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial were treated with citalopram under a standard protocol for up to 14 weeks. DNA samples from 1,915 participants were genotyped for 768 single-nucleotide polymorphisms in 68 candidate genes. Allele and genotype frequencies were compared between the 120 participants who developed treatment-emergent suicidal ideation and those who did not. Two markers were significantly associated with treatment-emergent suicidal ideation in this sample (marker rs4825476, p=0.0000784, odds ratio=1.94; permutation p=0.01; marker rs2518224, p=0.0000243, odds ratio=8.23; permutation p=0.003). These markers reside within the genes GRIA3 and GRIK2, respectively, both of which encode ionotropic glutamate receptors. Markers within GRIK2 and GRIA3 were associated with treatment-emergent suicidal ideation during citalopram therapy. If replicated, these findings may shed light on the biological basis of this potentially dangerous adverse event and help identify patients at increased risk. JF - The American journal of psychiatry AU - Laje, Gonzalo AU - Paddock, Silvia AU - Manji, Husseini AU - Rush, A John AU - Wilson, Alexander F AU - Charney, Dennis AU - McMahon, Francis J AD - Genetic Basis of Mood and Anxiety Disorders, NIMH, 35 Convent Dr., Rm. 1A207, Bethesda, MD 20892-3719, USA. gonzalo.laje@nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1530 EP - 1538 VL - 164 IS - 10 SN - 0002-953X, 0002-953X KW - Genetic Markers KW - 0 KW - Receptors, Glutamate KW - Serotonin Uptake Inhibitors KW - Citalopram KW - 0DHU5B8D6V KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Polymorphism, Single Nucleotide KW - Gene Frequency KW - Humans KW - Pharmacogenetics KW - Ambulatory Care KW - Genotype KW - Receptors, Glutamate -- genetics KW - Prospective Studies KW - Adult KW - Cohort Studies KW - Treatment Outcome KW - Female KW - Male KW - Citalopram -- therapeutic use KW - Depressive Disorder, Major -- drug therapy KW - Serotonin Uptake Inhibitors -- therapeutic use KW - Depressive Disorder, Major -- psychology KW - Depressive Disorder, Major -- genetics KW - Suicide -- psychology KW - Serotonin Uptake Inhibitors -- adverse effects KW - Citalopram -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68318553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Genetic+markers+of+suicidal+ideation+emerging+during+citalopram+treatment+of+major+depression.&rft.au=Laje%2C+Gonzalo%3BPaddock%2C+Silvia%3BManji%2C+Husseini%3BRush%2C+A+John%3BWilson%2C+Alexander+F%3BCharney%2C+Dennis%3BMcMahon%2C+Francis+J&rft.aulast=Laje&rft.aufirst=Gonzalo&rft.date=2007-10-01&rft.volume=164&rft.issue=10&rft.spage=1530&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Psychiatry. 2008 Mar;165(3):395; author reply 395-6 [18316433] Am J Psychiatry. 2007 Oct;164(10):1460-1 [17898330] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. AN - 68318417; 17898285 AB - A prior study showed that mice deficient in IFN-gamma (GKO) are more susceptible to experimental autoimmune uveitis (EAU) than are wild-type (WT) mice. Histopathology of uveitic eyes revealed that the ocular infiltrate in GKO mice was dominated by neutrophils and eosinophils rather than by mononuclear cells, as in WT mice. The present study was conducted to explore the differential expression of chemokine(s) likely to account for the distinct inflammatory cell composition in uveitic eyes of WT and GKO mice. Mice were immunized to induce EAU. Lymph nodes draining the site of the immunization and the eyes were collected at different time points for chemokine analysis. Microarray, real-time PCR and protein analyses were performed to examine the expression of chemokines in WT and GKO mice. Many chemokines were differentially upregulated in GKO versus WT mice. Expression of the Th1-associated chemokines CXCL10, CXCL9, CCL5, and CXCL11 was elevated in WT mice, whereas the Th2-associated chemokines CCL11, CCL17, and CCL1 and the Th17-associated chemokines CCL22 and CXCL2 were elevated in the GKO mice. Depletion of granulocytes abrogated EAU in both WT and GKO mice. These results suggest that Th1-associated chemokines play a critical role in the attraction of mononuclear cells to the eyes in the presence of IFN-gamma, while in the absence of this cytokine, Th2- and Th17-related chemokines may be the key elements for influx of granulocytes. JF - Investigative ophthalmology & visual science AU - Su, Shao Bo AU - Grajewski, Rafael S AU - Luger, Dror AU - Agarwal, Rajeev K AU - Silver, Phyllis B AU - Tang, Jun AU - Tuo, Jingsheng AU - Chan, Chi-Chao AU - Caspi, Rachel R AD - Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 4616 EP - 4625 VL - 48 IS - 10 SN - 0146-0404, 0146-0404 KW - Chemokines KW - 0 KW - Eye Proteins KW - Retinol-Binding Proteins KW - interstitial retinol-binding protein KW - RNA KW - 63231-63-0 KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Th1 Cells -- immunology KW - Animals KW - Lymph Nodes -- metabolism KW - Eosinophils -- physiology KW - Oligonucleotide Array Sequence Analysis KW - Granulocytes -- physiology KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Lymph Nodes -- cytology KW - Mice, Knockout KW - Leukocytes, Mononuclear -- physiology KW - Mice, Inbred C57BL KW - RNA -- isolation & purification KW - Th2 Cells -- immunology KW - Uveitis -- pathology KW - Interferon-gamma -- genetics KW - Gene Silencing -- physiology KW - Chemokines -- genetics KW - Uveitis -- immunology KW - Autoimmune Diseases -- genetics KW - Chemokines -- metabolism KW - Gene Expression Regulation -- physiology KW - Uveitis -- genetics KW - Autoimmune Diseases -- pathology KW - Autoimmune Diseases -- chemically induced KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68318417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Altered+chemokine+profile+associated+with+exacerbated+autoimmune+pathology+under+conditions+of+genetic+interferon-gamma+deficiency.&rft.au=Su%2C+Shao+Bo%3BGrajewski%2C+Rafael+S%3BLuger%2C+Dror%3BAgarwal%2C+Rajeev+K%3BSilver%2C+Phyllis+B%3BTang%2C+Jun%3BTuo%2C+Jingsheng%3BChan%2C+Chi-Chao%3BCaspi%2C+Rachel+R&rft.aulast=Su&rft.aufirst=Shao&rft.date=2007-10-01&rft.volume=48&rft.issue=10&rft.spage=4616&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1996 Jan 1;156(1):5-7 [8598493] Eur J Immunol. 1996 Jul;26(7):1641-6 [8766573] J Immunol. 1997 Jun 1;158(11):5501-6 [9164973] J Immunol. 1997 Jun 1;158(11):5507-13 [9164974] J Immunol. 1997 Jun 15;158(12):5997-6005 [9190954] Immunity. 1998 Mar;8(3):275-83 [9529145] J Immunol. 1998 May 15;160(10):5105-12 [9590262] J Immunol. 1998 Dec 1;161(11):6421-6 [9834134] J Exp Med. 1999 Jan 18;189(2):219-30 [9892605] J Neurovirol. 1999 Feb;5(1):95-101 [10190695] J Immunol. 2004 Dec 1;173(11):6993-7002 [15557196] J Dermatol Sci. 2004 Jun;35(1):43-51 [15194146] Prog Retin Eye Res. 2004 Jul;23(4):435-48 [15219876] J Immunol. 2004 Oct 1;173(7):4692-8 [15383605] Lab Invest. 2004 Nov;84(11):1418-29 [15322564] J Immunol. 1977 Dec;119(6):1949-58 [334977] Curr Top Eye Res. 1980;2:215-302 [7344837] J Immunol. 1986 Apr 1;136(7):2348-57 [2419430] J Immunol. 1988 Mar 1;140(5):1490-5 [3346541] Annu Rev Immunol. 1989;7:145-73 [2523712] J Autoimmun. 1990 Jun;3(3):247-55 [2397018] Photochem Photobiol. 1991 Dec;54(6):1057-60 [1775528] J Immunol. 1994 Jan 15;152(2):890-9 [8283058] Annu Rev Immunol. 1994;12:227-57 [8011282] J Immunol. 2005 Apr 15;174(8):5082-91 [15814739] J Immunol. 2005 May 1;174(9):5324-31 [15843529] Immunology. 2005 Sep;116(1):1-12 [16108812] J Rheumatol. 2005 Sep;32(9):1666-72 [16142858] Nat Immunol. 2005 Nov;6(11):1133-41 [16200068] Nat Immunol. 2005 Nov;6(11):1123-32 [16200070] Nat Immunol. 2005 Nov;6(11):1069-70 [16239919] Immunol Res. 2006;34(3):229-42 [16891673] Curr Opin Immunol. 2006 Dec;18(6):670-5 [17010592] J Immunol. 2007 May 1;178(9):5578-87 [17442940] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Nov;28(7):1129-34 [15610925] J Immunol. 2000 Mar 1;164(5):2759-68 [10679118] Curr Opin Immunol. 2000 Jun;12(3):336-41 [10781407] Exp Eye Res. 2000 Aug;71(2):111-8 [10930316] Invest Ophthalmol Vis Sci. 2001 Jun;42(7):1547-52 [11381059] J Immunol. 2001 Jun 15;166(12):7617-24 [11390519] J Immunol. 2001 Jul 1;167(1):250-6 [11418656] Biotechniques. 2001 Jul;31(1):186-90, 192-4 [11464511] Eur J Dermatol. 2002 Jan-Feb;12(1):27-31 [11809592] Methods. 2001 Dec;25(4):402-8 [11846609] J Immunol. 2002 Mar 1;168(5):2483-92 [11859142] Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5 [12605265] Scand J Immunol. 2003 Jul;58(1):81-8 [12828562] J Rheumatol. 2003 Nov;30(11):2369-73 [14677179] J Immunol. 2004 Jan 1;172(1):550-9 [14688366] Am J Reprod Immunol. 2004 Jan;51(1):32-9 [14725564] J Dermatol Sci. 2004 May;34(3):201-8 [15113590] Am J Respir Crit Care Med. 2004 May 15;169(10):1118-24 [15001464] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Plasticity and impact of the central renin-angiotensin system during development of ethanol dependence. AN - 68310127; 17823780 AB - Pharmacological and genetic interference with the renin-angiotensin system (RAS) seems to alter voluntary ethanol consumption. However, understanding the influence of the RAS on ethanol dependence and its treatment requires modeling the neuroadaptations that occur with prolonged exposure to ethanol. Increased ethanol consumption was induced in rats through repeated cycles of intoxication and withdrawal. Expression of angiotensinogen, angiotensin-converting enzyme, and the angiotensin II receptor, AT1a, was examined by quantitative reverse transcription polymerase chain reaction. Increased ethanol consumption after a history of dependence was associated with increased angiotensinogen expression in medial prefrontal cortex but not in nucleus accumbens or amygdala. Increased angiotensinogen expression also demonstrates that the astroglia is an integral part of the plasticity underlying the development of dependence. The effects of low central RAS activity on increased ethanol consumption were investigated using either spirapril, a blood-brain barrier-penetrating inhibitor of angiotensin-converting enzyme, or transgenic rats (TGR(ASrAOGEN)680) with reduced central angiotensinogen expression. Spirapril reduced ethanol intake in dependent rats compared to controls. After induction of dependence, TGR(ASrAOGEN)680 rats had increased ethanol consumption but to a lesser degree than Wistar rats with the same history of dependence. These data suggest that the central RAS is sensitized in its modulatory control of ethanol consumption in the dependent state, but pharmacological or genetic blockade of the system appears to be insufficient to halt the progression of dependence. JF - Journal of molecular medicine (Berlin, Germany) AU - Sommer, W H AU - Rimondini, R AU - Marquitz, M AU - Lidström, J AU - Siems, W-E AU - Bader, M AU - Heilig, M AD - Laboratory of Clinical and Translational Studies, NIAAA, NIH, Bldg 10, CRC, Bethesda, MD, 20892-1108, USA. wolfgang.sommer@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1089 EP - 1097 VL - 85 IS - 10 SN - 0946-2716, 0946-2716 KW - Angiotensin II Type 1 Receptor Blockers KW - 0 KW - Angiotensin-Converting Enzyme Inhibitors KW - RNA, Antisense KW - Receptors, Angiotensin KW - Angiotensinogen KW - 11002-13-4 KW - Angiotensin II KW - 11128-99-7 KW - Ethanol KW - 3K9958V90M KW - Enalapril KW - 69PN84IO1A KW - spirapril KW - 96U2K78I3V KW - Index Medicus KW - Angiotensinogen -- genetics KW - Animals KW - Angiotensinogen -- biosynthesis KW - Ethanol -- pharmacology KW - Humans KW - Disease Models, Animal KW - RNA, Antisense -- genetics KW - Animals, Genetically Modified KW - Angiotensin II Type 1 Receptor Blockers -- pharmacology KW - Angiotensin-Converting Enzyme Inhibitors -- pharmacology KW - Receptors, Angiotensin -- drug effects KW - Rats KW - Receptors, Angiotensin -- physiology KW - Rats, Wistar KW - Adaptation, Physiological KW - Enalapril -- analogs & derivatives KW - Enalapril -- pharmacology KW - RNA, Antisense -- biosynthesis KW - Central Nervous System -- metabolism KW - Angiotensin II -- drug effects KW - Angiotensin II -- physiology KW - Central Nervous System -- drug effects KW - Renin-Angiotensin System -- physiology KW - Neuronal Plasticity -- physiology KW - Neuronal Plasticity -- drug effects KW - Alcoholism -- metabolism KW - Renin-Angiotensin System -- drug effects KW - Alcoholism -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68310127?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.atitle=Plasticity+and+impact+of+the+central+renin-angiotensin+system+during+development+of+ethanol+dependence.&rft.au=Sommer%2C+W+H%3BRimondini%2C+R%3BMarquitz%2C+M%3BLidstr%C3%B6m%2C+J%3BSiems%2C+W-E%3BBader%2C+M%3BHeilig%2C+M&rft.aulast=Sommer&rft.aufirst=W&rft.date=2007-10-01&rft.volume=85&rft.issue=10&rft.spage=1089&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+medicine+%28Berlin%2C+Germany%29&rft.issn=09462716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-11 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contribution of nonesterified fatty acids to insulin resistance in the elderly with normal fasting but diabetic 2-hour postchallenge plasma glucose levels: the Baltimore Longitudinal Study of Aging. AN - 68308913; 17884459 AB - Isolated postchallenge hyperglycemia (IPH) with normal fasting plasma glucose or=200 mg/dL after an oral glucose tolerance test (OGTT) is a common occurrence in the elderly. We sought to understand what unique characteristics this population might have that puts it at risk for this particular metabolic finding. We therefore conducted a longitudinal study of volunteers in the Baltimore Longitudinal Study of Aging (BLSA). All volunteers had an OGTT performed (75 g) on 2 or more occasions. We measured plasma levels of glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), ghrelin, leptin, adiponectin, resistin, C-reactive protein, cytokines, and their soluble receptors, as well as nonesterified free fatty acids (NEFAs). We determined that 22 subjects in BLSA had IPH, accounting for 2.1% of the BLSA population. All 22 were older than 65 years. They were then matched by age, sex, and body mass index to 12 subjects who had isolated impaired glucose tolerance (IGT) and 15 subjects with normal glucose tolerance (NGT). All subjects had normal fasting glucose levels <100 mg/dL in accordance with the American Diabetes Association Expert Committee on the Classification and Diagnosis of Diabetes Mellitus criteria (2003). We found that subjects with IPH had similar plasma insulin levels to the other 2 groups, except at the 2-hour time when their insulin levels were higher than NGT (P < .05). Although there was a clear trend for differences in the insulinogenic index, the areas under the curves for insulin, systolic blood pressure, adiponectin, and C-reactive protein across the glucose tolerance categories revealed no statistical significance. Cytokines and their soluble receptors, gut hormones, and adipokines were similar in all 3 groups. The NEFA levels were significantly elevated in the fasting state (P < .05) in the IPH compared with NGT, with IGT intermediate between the other 2 groups. The rate of clearance of NEFAs after the OGTT decreased progressively from the NGT to the IPH group (in micromoles per liter per minute: NGT, 11.9 vs IGT, 7.6 vs IPH, 3.0). We conclude that the rate of suppression of lipolysis in the elderly determines the sensitivity of glucose uptake to insulin after OGTT. JF - Metabolism: clinical and experimental AU - Carlson, Olga D AU - David, Jehan D AU - Schrieder, Jessica M AU - Muller, Dennis C AU - Jang, Hyeung-Jin AU - Kim, Byung-Joon AU - Egan, Josephine M AD - National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1444 EP - 1451 VL - 56 IS - 10 SN - 0026-0495, 0026-0495 KW - Biomarkers KW - 0 KW - Blood Glucose KW - Cytokines KW - Fatty Acids, Nonesterified KW - Hemoglobin A, Glycosylated KW - Hormones KW - Insulin KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Cytokines -- blood KW - Glucose Tolerance Test KW - Fasting -- physiology KW - Insulin -- blood KW - Humans KW - Hormones -- blood KW - Aged KW - Longitudinal Studies KW - Aging -- physiology KW - Baltimore KW - Aged, 80 and over KW - Hemoglobin A, Glycosylated -- metabolism KW - Maryland KW - Biomarkers -- blood KW - Male KW - Female KW - Fatty Acids, Nonesterified -- physiology KW - Diabetes Mellitus -- metabolism KW - Blood Glucose -- metabolism KW - Hyperglycemia -- chemically induced KW - Insulin Resistance -- physiology KW - Hyperglycemia -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68308913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Metabolism%3A+clinical+and+experimental&rft.atitle=Contribution+of+nonesterified+fatty+acids+to+insulin+resistance+in+the+elderly+with+normal+fasting+but+diabetic+2-hour+postchallenge+plasma+glucose+levels%3A+the+Baltimore+Longitudinal+Study+of+Aging.&rft.au=Carlson%2C+Olga+D%3BDavid%2C+Jehan+D%3BSchrieder%2C+Jessica+M%3BMuller%2C+Dennis+C%3BJang%2C+Hyeung-Jin%3BKim%2C+Byung-Joon%3BEgan%2C+Josephine+M&rft.aulast=Carlson&rft.aufirst=Olga&rft.date=2007-10-01&rft.volume=56&rft.issue=10&rft.spage=1444&rft.isbn=&rft.btitle=&rft.title=Metabolism%3A+clinical+and+experimental&rft.issn=00260495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-29 N1 - Date created - 2007-09-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Metabolism. 2000 Oct;49(10):1318-25 [11079822] Nature. 2001 Jan 18;409(6818):307-12 [11201732] Diabetes Care. 2001 Apr;24(4):796-7 [11315860] Diabetes Care. 2001 May;24(5):933-41 [11347757] Diabetes Care. 2001 Aug;24(8):1397-402 [11473076] Diabetes Care. 2001 Oct;24(10):1734-8 [11574434] N Engl J Med. 2001 Dec 13;345(24):1772-4 [11742055] Am J Physiol Endocrinol Metab. 2002 Feb;282(2):E419-27 [11788375] J Clin Invest. 2002 May;109(10):1345-50 [12021250] J Clin Endocrinol Metab. 2002 Oct;87(10):4652-6 [12364452] Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E281-90 [12531742] Diabetes. 2003 Feb;52(2):260-7 [12540595] J Clin Endocrinol Metab. 2003 Jul;88(7):3444-6 [12843200] Diabetes Care. 2003 Nov;26(11):3160-7 [14578255] Metabolism. 2003 Nov;52(11):1523-4; discussion 1524-5 [14635635] Diabet Med. 2004 May;21(5):497-9 [15089799] J Clin Endocrinol Metab. 2004 Jun;89(6):2548-56 [15181022] Diabetes Care. 2004 Jul;27(7):1692-8 [15220248] Diabetes. 2004 Aug;53(8):2095-100 [15277391] Diabetologia. 1985 Jul;28(7):412-9 [3899825] Diabetologia. 1986 Jan;29(1):46-52 [3514343] Diabetes. 1988 Jun;37(6):736-44 [3289994] J Gerontol. 1989 Mar;44(2):M66-73 [2921472] Mol Cell Biol. 1990 Apr;10(4):1498-506 [2181276] Science. 1993 Jan 1;259(5091):87-91 [7678183] J Gerontol. 1994 Jul;49(4):B135-9 [8014384] Diabetologia. 1995 Mar;38(3):326-36 [7758880] Diabetes Care. 1998 Aug;21(8):1236-9 [9702426] J Clin Invest. 1999 Jan;103(2):253-9 [9916137] Exp Clin Endocrinol Diabetes. 1999;107(2):107-10 [10320049] Cytokine. 1999 May;11(5):334-46 [10328873] Diabetologia. 1999 Sep;42(9):1050-4 [10447514] Diabetes. 1999 Sep;48(9):1836-41 [10480616] Diabetes Care. 1999 Oct;22(10):1667-71 [10526732] Diabetes Metab. 2004 Sep;30(4):294-309 [15525872] Horm Metab Res. 2004 Nov-Dec;36(11-12):742-6 [15655702] Clin Sci (Lond). 2005 Sep;109(3):243-56 [16104844] J Clin Endocrinol Metab. 2005 Dec;90(12):6665-71 [16174724] Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E550-9 [16219666] Diabetologia. 2006 Apr;49(4):744-7 [16496121] Diabet Med. 2006 Sep;23(9):982-9 [16922704] J Clin Endocrinol Metab. 2004 Apr;89(4):1844-8 [15070954] Diabetes Care. 2000 Mar;23(3):295-301 [10868854] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurological effects of high-dose idebenone in patients with Friedreich's ataxia: a randomised, placebo-controlled trial. AN - 68308156; 17826341 AB - Friedreich's ataxia (FA) is a progressive, multisystem, degenerative disorder caused by a reduction in frataxin. Loss of frataxin results in mitochondrial dysfunction and oxidative damage in patients and model systems. Previous studies have indicated that the antioxidant idebenone (5 mg/kg daily) reduces cardiac hypertrophy, but definite improvement in neurological function has not been shown. 48 genetically confirmed FA patients, aged 9-17 years, were enrolled in a 6-month, randomised, double-blind, placebo-controlled study. The patients received placebo or one of three doses of idebenone (approximately 5 mg/kg, 15 mg/kg, and 45 mg/kg), stratified by body weight. The primary endpoint was change from baseline in urinary 8-hydroxy-2'-deoxyguanosine (8OH2'dG), a marker of oxidative DNA damage. Secondary endpoints included changes in the international cooperative ataxia rating scale (ICARS), the FA rating scale (FARS), and a survey of activities of daily living (ADL). This study is registered with ClinicalTrials.gov, number NCT00229632. Idebenone was generally well tolerated with similar numbers of adverse events in each group. One child receiving high-dose idebenone developed neutropenia after 6 months, which resolved after discontinuation of treatment. 8OH2'dG concentrations were not increased, and did not significantly change with idebenone treatment. Whereas an overall analysis did not show a significant difference in ICARS, FARS, or ADL total scores, there were indications of a dose-dependent response in the ICARS score. A second, pre-specified analysis, excluding patients who required wheelchair assistance, showed a significant improvement in ICARS (Bonferroni p=0.03) and suggested a dose-related response in ICARS, FARS, and ADL scores. Treatment with higher doses of idebenone was generally well tolerated and associated with improvement in neurological function and ADL in patients with FA. The degree of improvement correlated with the dose of idebenone, suggesting that higher doses may be necessary to have a beneficial effect on neurological function. JF - The Lancet. Neurology AU - Di Prospero, Nicholas A AU - Baker, Angela AU - Jeffries, Neal AU - Fischbeck, Kenneth H AD - Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-3705, USA. diprospern@ninds.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 878 EP - 886 VL - 6 IS - 10 SN - 1474-4422, 1474-4422 KW - Antioxidants KW - 0 KW - Benzoquinones KW - Ubiquinone KW - 1339-63-5 KW - 8-oxo-7-hydrodeoxyguanosine KW - 88847-89-6 KW - Deoxyguanosine KW - G9481N71RO KW - idebenone KW - HB6PN45W4J KW - Index Medicus KW - Severity of Illness Index KW - DNA Damage KW - Dose-Response Relationship, Drug KW - Humans KW - Activities of Daily Living KW - Neutropenia -- chemically induced KW - Child KW - Ubiquinone -- analogs & derivatives KW - Deoxyguanosine -- urine KW - Adolescent KW - Female KW - Male KW - Deoxyguanosine -- analogs & derivatives KW - Benzoquinones -- therapeutic use KW - Antioxidants -- adverse effects KW - Friedreich Ataxia -- physiopathology KW - Friedreich Ataxia -- drug therapy KW - Benzoquinones -- adverse effects KW - Nervous System -- drug effects KW - Antioxidants -- therapeutic use KW - Nervous System -- physiopathology KW - Friedreich Ataxia -- urine KW - Friedreich Ataxia -- genetics KW - Benzoquinones -- administration & dosage KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68308156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Lancet.+Neurology&rft.atitle=Neurological+effects+of+high-dose+idebenone+in+patients+with+Friedreich%27s+ataxia%3A+a+randomised%2C+placebo-controlled+trial.&rft.au=Di+Prospero%2C+Nicholas+A%3BBaker%2C+Angela%3BJeffries%2C+Neal%3BFischbeck%2C+Kenneth+H&rft.aulast=Di+Prospero&rft.aufirst=Nicholas&rft.date=2007-10-01&rft.volume=6&rft.issue=10&rft.spage=878&rft.isbn=&rft.btitle=&rft.title=The+Lancet.+Neurology&rft.issn=14744422&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-02 N1 - Date created - 2007-09-21 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00229632; ClinicalTrials.gov N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality among shipyard Coast Guard workers: a retrospective cohort study. AN - 68302992; 17881470 AB - The mortality experience of 4702 (4413 men and 289 women) civilian workers in a US Coast Guard shipyard was evaluated. All workers employed at the shipyard between 1 January 1950 and 31 December 1964 were included in the study and were followed through 31 December 2001 for vital status. Detailed shipyard and lifetime work histories found in the shipyard personnel records and job descriptions were evaluated. Workers were classified as likely exposed to any potential hazardous substances. In addition, 20 job groups were created on likely similar exposures. Standardised mortality ratios (SMRs) were calculated based on the general population of the state and adjusted for age, calendar period, sex and race. The follow-up was successful for 93.3% of the workers. Among all men employed in the shipyard, there was an excess of mortality from all causes of death (SMR 1.08; 95% CI 1.04 to 1.12), respiratory cancers (SMR 1.29; 95% CI 1.15 to 1.43), lung cancer (SMR 1.26; 95% CI 1.12 to 1.41), mesothelioma (SMR 5.07; 95% CI 1.85 to 11.03) and emphysema (SMR 1.44; 95% CI 1.01 to 1.99) and a decrease for cardiovascular diseases (OR 0.95; 95% CI 0.90 to 1.00), vascular lesions of the central nervous system (SMR 0.80; 95% CI 0.67 to 0.96), cirrhosis of the liver (SMR 0.38; 95% CI 0.25 to 0.57) and external causes of death (SMR 0.55; 95% CI 0.44 to 0.68). A similar pattern was observed for the men classified as exposed. No increasing trend of mortality was found with duration of employment in the shipyard, with the exception of mesothelioma (SMRs of 4.23 and 6.27 for or =10 years, respectively). In occupations with at least three cases and with an SMR of > or =1.3, the authors observed a significantly elevated mortality for lung cancer among machinists (SMR 1.60; 95% CI 1.08 to 2.29) and shipfitters, welders and cutters (SMR 1.34; 95% CI 1.07 to 1.65) and for oral and nasopharyngeal cancers among wood workers (SMR 6.20; 95% CI 2.27 to 13.50). Employment in this Coast Guard shipyard revealed a small but significant excess mortality from all causes, lung cancer and mesothelioma, most of which is probably related to asbestos exposure. JF - Occupational and environmental medicine AU - Krstev, S AU - Stewart, P AU - Rusiecki, J AU - Blair, A AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 651 EP - 658 VL - 64 IS - 10 KW - Index Medicus KW - Causality KW - Occupational Exposure -- statistics & numerical data KW - Neoplasms -- mortality KW - Humans KW - Retrospective Studies KW - Aged KW - Baltimore -- epidemiology KW - Employment -- statistics & numerical data KW - Cardiovascular Diseases -- mortality KW - Continental Population Groups -- statistics & numerical data KW - Adult KW - Cohort Studies KW - Middle Aged KW - Respiratory Tract Diseases -- mortality KW - Sex Distribution KW - Female KW - Male KW - Ships KW - Military Personnel -- statistics & numerical data KW - Occupational Diseases -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302992?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+environmental+medicine&rft.atitle=Mortality+among+shipyard+Coast+Guard+workers%3A+a+retrospective+cohort+study.&rft.au=Krstev%2C+S%3BStewart%2C+P%3BRusiecki%2C+J%3BBlair%2C+A&rft.aulast=Krstev&rft.aufirst=S&rft.date=2007-10-01&rft.volume=64&rft.issue=10&rft.spage=651&rft.isbn=&rft.btitle=&rft.title=Occupational+and+environmental+medicine&rft.issn=1470-7926&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-18 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Ind Med. 2003 Apr;43(4):350-60 [12645092] Ind Health. 2003 Apr;41(2):94-100 [12725469] Cancer Causes Control. 2003 Apr;14(3):203-12 [12814199] Semin Nephrol. 2003 Sep;23(5):500-8 [13680539] Respir Care. 2003 Dec;48(12):1185-91; discussion 1191-3 [14651759] Cancer Causes Control. 2004 Apr;15(3):285-94 [15090723] Am J Ind Med. 2004 Jun;45(6):483-90 [15164392] J Occup Health. 2004 Jul;46(4):266-71 [15308825] Br J Ind Med. 1972 Apr;29(2):142-5 [5021994] Environ Res. 1976 Apr;11(2):271-9 [939218] Br J Prev Soc Med. 1976 Dec;30(4):225-30 [1009272] N Engl J Med. 1978 Sep 21;299(12):620-4 [683235] Ann N Y Acad Sci. 1979;330:295-311 [294180] J Natl Cancer Inst. 1980 Sep;65(3):571-5 [6931936] Int Arch Occup Environ Health. 1985;55(4):277-83 [4008052] Cancer Res. 1985 Aug;45(8):3924-8 [4016758] Int Arch Occup Environ Health. 1987;59(5):455-62 [3653990] Am J Ind Med. 1988;13(1):105-18 [3344750] Am J Ind Med. 1988;13(1):59-69 [3344756] Am Ind Hyg Assoc J. 1988 Mar;49(3):121-7 [3376873] Br J Ind Med. 1988 Apr;45(4):209-18 [3377996] Arch Environ Health. 1989 May-Jun;44(3):150-6 [2751350] Cancer. 1989 Dec 15;64(12):2609-13 [2819671] Br J Ind Med. 1991 Mar;48(3):145-54 [2015204] Eur Respir J. 1992 Mar;5(3):281-5 [1572439] Occup Med (Lond). 1992 Nov;42(4):203-12 [1295495] Cancer Epidemiol Biomarkers Prev. 1992 Jul-Aug;1(5):345-8 [1305465] Int Arch Occup Environ Health. 1993;65(1):35-41 [8354573] Am Ind Hyg Assoc J. 1993 Jul;54(7):392-6 [8362760] Br J Ind Med. 1993 Dec;50(12):1097-103 [8280640] Ann Occup Hyg. 1995 Jun;39(3):363-74 [7793754] Chest. 1995 Sep;108(3):647-55 [7656611] J Occup Environ Med. 2000 Jan;42(1):101-9 [10652696] Am J Ind Med. 2000 May;37(5):512-21 [10723045] Occup Environ Med. 2000 Jun;57(6):376-84 [10810126] Cancer Causes Control. 2001 May;12(4):365-74 [11456233] Am J Ind Med. 2001 Oct;40(4):363-70 [11598985] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1145-53 [11700262] Am J Ind Med. 2002 Jul;42(1):11-22 [12111686] Scand J Work Environ Health. 2002 Aug;28(4):278-84 [12199430] Semin Cancer Biol. 2002 Dec;12(6):421-9 [12450728] Med Lav. 1997 Jul-Aug;88(4):316-20 [9396217] Cancer Causes Control. 1997 May;8(3):491-503 [9498906] Scand J Work Environ Health. 1998;24 Suppl 2:25-41 [9714511] Ind Health. 1999 Jan;37(1):9-17 [10052294] Environ Health Perspect. 1999 May;107 Suppl 2:289-98 [10350513] Environ Health Perspect. 2004 Nov;112(15):1539-43 [15531439] Occup Med (Lond). 2005 Mar;55(2):79-87 [15757980] Occup Environ Med. 2005 May;62(5):318-24 [15837853] J Occup Environ Med. 2006 Jan;48(1):1-12 [16404204] Comment In: Occup Environ Med. 2007 Oct;64(10):639-41 [17881468] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Population pharmacokinetics of micafungin in pediatric patients and implications for antifungal dosing. AN - 68302922; 17638696 AB - The echinocandins potentially have an important role in treatment of infections caused by Candida spp. and Aspergillus spp. in immunocompromised children. However, there are no population pharmacokinetic models of the echinocandins for pediatric patients. The safety and descriptive pharmacokinetics of micafungin in children were recently reported. However, a population pharmacokinetic model in children is needed in order to accurately determine the dosage of micafungin that produces an equivalent magnitude of drug exposure to that observed in adults. In order to explore the effect of weight on micafungin pharmacokinetics, a standard two-compartment pharmacokinetic model, a linear model, and an allometric power model were developed. For all three models, the fit to the data was excellent, with comparable measures of precision and bias. However, the superior log-likelihood value of the allometric power model suggested that it best reflected the data and was therefore chosen for a more detailed analysis of the magnitude and pattern of drug exposure which develop following the administration of micafungin. The allometric power model suggested that clearance in smaller children is higher than that predicted on the basis of weight alone. Consequently, a degree of dosage increase is required in smaller children to ensure comparable levels of drug exposure to those observed in larger children and adults. The allometric power model developed in this study enables identification of pediatric dosage regimens of micafungin which, based upon Monte Carlo simulations, result in equivalent drug exposures to those observed in adults, for which antifungal efficacy has been established. JF - Antimicrobial agents and chemotherapy AU - Hope, William W AU - Seibel, Nita L AU - Schwartz, Cindy L AU - Arrieta, Antonio AU - Flynn, Patricia AU - Shad, Aziza AU - Albano, Edythe AU - Keirns, James J AU - Buell, Donald N AU - Gumbo, Tawanda AU - Drusano, George L AU - Walsh, Thomas J AD - Pediatric Oncology Branch, NCI/NIH, CRC Room 1-5750, Bethesda, MD 20892-1100, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 3714 EP - 3719 VL - 51 IS - 10 SN - 0066-4804, 0066-4804 KW - Antifungal Agents KW - 0 KW - Echinocandins KW - Lipopeptides KW - Lipoproteins KW - micafungin KW - R10H71BSWG KW - Index Medicus KW - Area Under Curve KW - Humans KW - Linear Models KW - Algorithms KW - Bayes Theorem KW - Models, Statistical KW - Child KW - Monte Carlo Method KW - Child, Preschool KW - Population KW - Forecasting KW - Adolescent KW - Female KW - Male KW - Lipoproteins -- pharmacokinetics KW - Lipoproteins -- administration & dosage KW - Antifungal Agents -- pharmacokinetics KW - Antifungal Agents -- adverse effects KW - Echinocandins -- administration & dosage KW - Lipoproteins -- adverse effects KW - Echinocandins -- pharmacokinetics KW - Antifungal Agents -- administration & dosage KW - Echinocandins -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+agents+and+chemotherapy&rft.atitle=Population+pharmacokinetics+of+micafungin+in+pediatric+patients+and+implications+for+antifungal+dosing.&rft.au=Hope%2C+William+W%3BSeibel%2C+Nita+L%3BSchwartz%2C+Cindy+L%3BArrieta%2C+Antonio%3BFlynn%2C+Patricia%3BShad%2C+Aziza%3BAlbano%2C+Edythe%3BKeirns%2C+James+J%3BBuell%2C+Donald+N%3BGumbo%2C+Tawanda%3BDrusano%2C+George+L%3BWalsh%2C+Thomas+J&rft.aulast=Hope&rft.aufirst=William&rft.date=2007-10-01&rft.volume=51&rft.issue=10&rft.spage=3714&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+agents+and+chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-28 N1 - Date created - 2007-09-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacokinet. 1996 May;30(5):329-32 [8743333] Pediatr Infect Dis J. 2006 Dec;25(12):1110-5 [17133155] Lancet. 2003 Oct 4;362(9390):1142-51 [14550704] Br J Anaesth. 2004 Feb;92(2):208-17 [14722170] Nat Rev Microbiol. 2004 Apr;2(4):289-300 [15031728] Clin Pharmacokinet. 1997 Nov;33(5):313-27 [9391745] Antimicrob Agents Chemother. 2005 Aug;49(8):3317-24 [16048942] Pediatr Infect Dis J. 2005 Aug;24(8):736-9 [16094234] Med Mycol. 2005 May;43 Suppl 1:S247-59 [16110817] Bone Marrow Transplant. 2005 Oct;36(7):621-9 [16044133] Antimicrob Agents Chemother. 2005 Nov;49(11):4536-45 [16251293] Antimicrob Agents Chemother. 2005 Dec;49(12):5092-8 [16304177] Br J Clin Pharmacol. 2006 Jan;61(1):39-48 [16390350] Antimicrob Agents Chemother. 2006 Feb;50(2):632-8 [16436720] Pediatr Infect Dis J. 2006 Jul;25(7):634-9 [16804435] Pediatrics. 2003 Sep;112(3 Pt 1):634-40 [12949295] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clozapine treatment of childhood-onset schizophrenia: evaluation of effectiveness, adverse effects, and long-term outcome. AN - 68301043; 17885577 AB - Clozapine is a unique atypical antipsychotic with superior efficacy in treatment-resistant schizophrenia. Plasma concentration of clozapine and its major metabolite N-desmethylclozapine (NDMC) as well as the ratio of NDMC to clozapine have been reported to be predictors of clozapine response. Here we evaluate these as well as other measures in an effort to find predictors of response to clozapine in our early-onset treatment-refractory population. Fifty-four children and adolescents participated in double-blind (n = 22) or open-label (n = 32) clozapine trials. Clinical evaluations took place at baseline, week 6 on clozapine, and at 2- to 6-year follow-up. The data were analyzed in relation to demographics, age at onset, IQ, clozapine dose, and plasma concentrations of prolactin, clozapine, NDMC, and NDMC/clozapine ratio. Stepwise regression and correlation analyses were performed to find predictors of treatment response. Clinical improvement after 6 weeks of clozapine treatment, as measured by the percentage of improvement on the Brief Psychiatric Rating Scale and the Scale for the Assessment of Positive Symptoms, was strongly associated with the NDMC/clozapine ratio at the 6-week time point (Pearson correlation coefficient: r = 0.41; p < .01 for Brief Psychiatric Rating Scale and r = 0.43; p < .01 for Scale for the Assessment of Positive Symptoms). Although the rate of side effects was higher than that typically found in the adult population, it did not appear to be related to clozapine dose, clozapine or NDMC plasma concentrations, or NDMC/clozapine ratio. Outcome at long-term follow-up, as measured by Children's Global Assessment Scale, was associated with lesser illness severity at baseline and with greater improvement during the initial 6 weeks of clozapine treatment. The NDMC/clozapine ratio may be a valuable predictor of response to clozapine and may suggest new approaches to clozapine treatment. JF - Journal of the American Academy of Child and Adolescent Psychiatry AU - Sporn, Alexandra L AU - Vermani, Anoop AU - Greenstein, Deanna K AU - Bobb, Aaron J AU - Spencer, Edgar P AU - Clasen, Liv S AU - Tossell, Julia W AU - Stayer, Catherine C AU - Gochman, Peter A AU - Lenane, Marge C AU - Rapoport, Judith L AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH, Bethesda, MD, USA. als2168@columbia.edu Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1349 EP - 1356 VL - 46 IS - 10 SN - 0890-8567, 0890-8567 KW - Antipsychotic Agents KW - 0 KW - Clozapine KW - J60AR2IKIC KW - Index Medicus KW - Double-Blind Method KW - Age of Onset KW - Humans KW - Treatment Outcome KW - Child KW - Brief Psychiatric Rating Scale KW - Adolescent KW - Time Factors KW - Male KW - Female KW - Schizophrenia, Childhood -- diagnosis KW - Clozapine -- therapeutic use KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia, Childhood -- drug therapy KW - Clozapine -- adverse effects KW - Antipsychotic Agents -- adverse effects KW - Schizophrenia, Childhood -- epidemiology KW - Drug Therapy -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68301043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.atitle=Clozapine+treatment+of+childhood-onset+schizophrenia%3A+evaluation+of+effectiveness%2C+adverse+effects%2C+and+long-term+outcome.&rft.au=Sporn%2C+Alexandra+L%3BVermani%2C+Anoop%3BGreenstein%2C+Deanna+K%3BBobb%2C+Aaron+J%3BSpencer%2C+Edgar+P%3BClasen%2C+Liv+S%3BTossell%2C+Julia+W%3BStayer%2C+Catherine+C%3BGochman%2C+Peter+A%3BLenane%2C+Marge+C%3BRapoport%2C+Judith+L%3BGogtay%2C+Nitin&rft.aulast=Sporn&rft.aufirst=Alexandra&rft.date=2007-10-01&rft.volume=46&rft.issue=10&rft.spage=1349&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+and+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-08 N1 - Date created - 2007-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A broader view of change in drinking behavior. AN - 68293515; 17880354 AB - Most research concerning change in drinking behavior has taken place within the context of specialized treatment for a help-seeking population. However, treatment approaches with different purported mechanisms of action yield very similar results, suggesting that common elements, rather than specific mechanisms, may be responsible for the bulk of the individual change process. Mechanisms of change have not been explicitly examined. Other factors such as social pressure may be more important mediators of change, which may occur prior to treatment entry. Also, most change occurs outside the context of specific treatment. A broader perspective focusing on mechanisms of change will need to account for change occurring both with and without professional treatment. Future research must be interdisciplinary in nature, seeking to relate social, behavioral, and neurophysiologic correlates of behavior change. JF - Alcoholism, clinical and experimental research AU - Willenbring, Mark L AD - National Institute on Alcohol Abuse and Alcoholism, 5635 Fishers Lane, Bethesda, MD 20892, USA. mlw@niaaa.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 84s EP - 86s VL - 31 IS - 10 Suppl SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Sociology KW - Behavior Therapy KW - Humans KW - Alcoholism -- therapy KW - Alcohol Drinking KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68293515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=A+broader+view+of+change+in+drinking+behavior.&rft.au=Willenbring%2C+Mark+L&rft.aulast=Willenbring&rft.aufirst=Mark&rft.date=2007-10-01&rft.volume=31&rft.issue=10+Suppl&rft.spage=84s&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The search for mechanisms of behavior change in evidence-based behavioral treatments for alcohol use disorders: overview. AN - 68292272; 17880340 AB - Over the past three decades, the main question of interest to alcohol treatment researchers has concerned the main effects of a particular behavioral intervention or what works. Increasingly, alcohol treatment researchers are turning their attention to the underlying psychological, social, and even neurophysiologic processes or "active ingredients" that are driving therapeutic change. The articles contained in this supplement to Alcoholism: Clinical and Experimental Research grew out of invited presentations given at a one-day satellite session immediately preceding the 28th Annual Meeting of the Research Society on Alcoholism (RSA). The conference was a collaborative effort of the Center on Alcoholism, Substance Abuse, and Addiction at the University of New Mexico, the Center on Addiction and Substance Abuse at Columbia University, Brown University, and the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health. The conference featured a mix of full-length presentations on conceptual and methodological issues, reports of original research findings, and lively discussion among speakers and conference participants. Understanding mechanisms of behavior change will benefit the field by identifying the key aspects of therapy that must be present for maximum effect, irrespective of the specific technique being applied; provide a new way to approach patient-treatment interactions; and lay the groundwork for understanding how change is affected by social and other extratreatment factors. Although not a new topic to the field, understanding mechanisms of behavior change has begun to capture the interest of an increasing number of alcohol treatment researchers. Understanding behavior change is an exceedingly complex enterprise and innovative thinking and creative research designs will be required to advance the field. JF - Alcoholism, clinical and experimental research AU - Huebner, Robert B AU - Tonigan, Jeffery Scott AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane, Bethesda, MD 20892, USA. bhuebner@niaaa.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1s EP - 3s VL - 31 IS - 10 Suppl SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Evidence-Based Medicine KW - Humans KW - Treatment Outcome KW - Behavior Therapy KW - Alcoholism -- therapy KW - Alcohol Drinking KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68292272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=The+search+for+mechanisms+of+behavior+change+in+evidence-based+behavioral+treatments+for+alcohol+use+disorders%3A+overview.&rft.au=Huebner%2C+Robert+B%3BTonigan%2C+Jeffery+Scott&rft.aulast=Huebner&rft.aufirst=Robert&rft.date=2007-10-01&rft.volume=31&rft.issue=10+Suppl&rft.spage=1s&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-08 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - [N-allyl-Dmt1]-endomorphins are micro-opioid receptor antagonists lacking inverse agonist properties. AN - 68291914; 17626793 AB - [N-allyl-Dmt1]-endomorphin-1 and -2 ([N-allyl-Dmt1]-EM-1 and -2) are new selective micro-opioid receptor antagonists obtained by N-alkylation with an allyl group on the amino terminus of 2',6'-dimethyl-L-tyrosine (Dmt) derivatives. To further characterize properties of these compounds, their intrinsic activities were assessed by functional guanosine 5'-O-(3-[35S]thiotriphosphate) binding assays and forskolin-stimulated cyclic AMP accumulation in cell membranes obtained from vehicle, morphine, and ethanol-treated SK-N-SH cells and brain membranes isolated from naive and morphine-dependent mice; their mode of action was compared with naloxone or naltrexone, which both are standard nonspecific opioid-receptor antagonists. [N-allyl-Dmt1]-EM-1 and -2 were neutral antagonists under all of the experimental conditions examined, in contrast to naloxone and naltrexone, which behave as neutral antagonists only in membranes from vehicle-treated cells and mice but act as inverse agonists in membranes from morphine- and ethanol-treated cells as well as morphine-treated mice. Both endomorphin analogs inhibited the naloxone- and naltrexone-elicited withdrawal syndromes from acute morphine dependence in mice. This suggests their potential therapeutic application in the treatment of drug addiction and alcohol abuse without the adverse effects observed with inverse agonist alkaloid-derived compounds that produce severe withdrawal symptoms. JF - The Journal of pharmacology and experimental therapeutics AU - Marczak, Ewa D AU - Jinsmaa, Yunden AU - Li, Tingyou AU - Bryant, Sharon D AU - Tsuda, Yuko AU - Okada, Yoshio AU - Lazarus, Lawrence H AD - Medicinal Chemistry Group, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, P.O. Box 12233, MD C304, Research Triangle Park, NC 27709, USA. marczake@niehs.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 374 EP - 380 VL - 323 IS - 1 SN - 0022-3565, 0022-3565 KW - Analgesics, Opioid KW - 0 KW - Oligopeptides KW - Receptors, Opioid, mu KW - endomorphin 1 KW - 2',6'-dimethyltyrosine KW - 123715-02-6 KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - endomorphin 2 KW - 3PH5M0466G KW - Tyrosine KW - 42HK56048U KW - Cyclic AMP KW - E0399OZS9N KW - Index Medicus KW - Animals KW - Substance Withdrawal Syndrome -- etiology KW - Cyclic AMP -- metabolism KW - Guanosine 5'-O-(3-Thiotriphosphate) -- metabolism KW - Mice KW - Radioligand Assay KW - Protein Binding KW - Male KW - Cell Line KW - Brain -- cytology KW - Cell Membrane -- drug effects KW - Brain -- drug effects KW - Oligopeptides -- chemistry KW - Brain -- metabolism KW - Tyrosine -- chemistry KW - Analgesics, Opioid -- chemistry KW - Analgesics, Opioid -- pharmacology KW - Receptors, Opioid, mu -- agonists KW - Receptors, Opioid, mu -- antagonists & inhibitors KW - Oligopeptides -- pharmacology KW - Tyrosine -- analogs & derivatives KW - Analgesics, Opioid -- adverse effects KW - Cell Membrane -- metabolism KW - Oligopeptides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68291914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=%5BN-allyl-Dmt1%5D-endomorphins+are+micro-opioid+receptor+antagonists+lacking+inverse+agonist+properties.&rft.au=Marczak%2C+Ewa+D%3BJinsmaa%2C+Yunden%3BLi%2C+Tingyou%3BBryant%2C+Sharon+D%3BTsuda%2C+Yuko%3BOkada%2C+Yoshio%3BLazarus%2C+Lawrence+H&rft.aulast=Marczak&rft.aufirst=Ewa&rft.date=2007-10-01&rft.volume=323&rft.issue=1&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural determinates for apolipoprotein E-derived peptide interaction with the alpha7 nicotinic acetylcholine receptor. AN - 68286937; 17609418 AB - Neuronal nicotinic acetylcholine receptor (nAChR) signaling has been implicated in a variety of normal central nervous system (CNS) functions as well as an array of neuropathologies. Previous studies have demonstrated both neurotoxic and neuroprotective actions of peptides derived from apolipoprotein E (apoE). It has been discovered that apoE-derived peptides inhibit native and recombinant alpha7-containing nAChRs, indicating a direct interaction between apoE peptides and nAChRs. To probe the structure/function interaction between alpha7 nAChRs and the apoE peptide apoE(141-148), experiments were conducted in Xenopus laevis oocytes expressing wild-type and mutated nAChRs. Mutation of Trp55 to alanine blocks apoE peptide-induced inhibition of acetylcholine (ACh)-mediated alpha7 nAChR responses. Additional mutations at Trp55 suggest that hydrophobic interactions between the receptor and apoE(141-148) are essential for inhibition of alpha7 nAChR function. A mutated apoE peptide also demonstrated decreased inhibition at alpha7-W55A nAChRs as well as activity-dependent inhibition of both wild-type alpha7 nAChRs and alpha7-W55A receptors. Finally, a three-dimensional model of the alpha7 nAChR was developed based on the recently refined Torpedo marmorata nACh receptor. A structural model is proposed for the binding of apoE(141-148) to the alpha7 nAChR where the peptide binds at the interface between two subunits, near the ACh binding site. Similar to the functional data, the computational docking suggests the importance of hydrophobic interactions between the alpha7 nAChR and the apoE peptide for inhibition of receptor function. The current data suggest a mode for apoE peptide binding that directly blocks alpha7 nAChR activity and consequently may disrupt nAChR signaling. JF - Molecular pharmacology AU - Gay, Elaine A AU - Bienstock, Rachelle J AU - Lamb, Patricia W AU - Yakel, Jerrel L AD - NIEHS, F2-08, P.O. Box 12233, 111 T. W. Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 838 EP - 849 VL - 72 IS - 4 SN - 0026-895X, 0026-895X KW - Apolipoproteins E KW - 0 KW - Peptide Fragments KW - Receptors, Nicotinic KW - alpha7 Nicotinic Acetylcholine Receptor KW - Index Medicus KW - Xenopus laevis KW - Animals KW - Torpedo KW - Protein Binding KW - Mutation KW - Signal Transduction KW - Protein Conformation KW - Peptide Fragments -- metabolism KW - Apolipoproteins E -- metabolism KW - Receptors, Nicotinic -- metabolism KW - Receptors, Nicotinic -- genetics KW - Apolipoproteins E -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68286937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Structural+determinates+for+apolipoprotein+E-derived+peptide+interaction+with+the+alpha7+nicotinic+acetylcholine+receptor.&rft.au=Gay%2C+Elaine+A%3BBienstock%2C+Rachelle+J%3BLamb%2C+Patricia+W%3BYakel%2C+Jerrel+L&rft.aulast=Gay&rft.aufirst=Elaine&rft.date=2007-10-01&rft.volume=72&rft.issue=4&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Neurobiol. 2002 Dec;53(4):431-46 [12436411] Mol Pharmacol. 2007 Feb;71(2):389-97 [17065235] J Neurobiol. 2002 Dec;53(4):580-9 [12436422] J Neurobiol. 2002 Dec;53(4):633-40 [12436426] J Neurobiol. 2002 Dec;53(4):641-55 [12436427] J Biol Chem. 2003 Jan 10;278(2):757-64 [12384509] Proteins. 2003 Jul 1;52(1):80-7 [12784371] Proteins. 2003 Nov 15;53(3):693-707 [14579360] Neuron. 2004 Mar 25;41(6):907-14 [15046723] Neuroscience. 2004;127(3):563-7 [15283956] J Biol Chem. 1971 Apr 10;246(7):2211-7 [5555568] Prog Biophys Mol Biol. 1972;24:107-23 [4566650] Proteins. 1992 Apr;12(4):345-64 [1579569] J Biol Chem. 1995 May 19;270(20):11749-52 [7744821] Biochemistry. 1995 Sep 5;34(35):11142-51 [7669772] Trends Biochem Sci. 1995 Nov;20(11):478-80 [8578593] Neuroreport. 1996 Nov 4;7(15-17):2529-32 [8981417] J Neurosci. 1997 Aug 1;17(15):5678-86 [9221767] Br J Pharmacol. 1998 Nov;125(5):924-47 [9846630] Exp Neurol. 2005 Mar;192(1):109-16 [15698624] J Mol Biol. 2005 Mar 4;346(4):967-89 [15701510] Neurosci Lett. 2005 Jun 24;381(3):305-8 [15896489] Proteins. 2005 Aug 1;60(2):207-13 [15981263] Nat Struct Mol Biol. 2005 Jul;12(7):582-8 [15951818] J Biol Chem. 2005 Jul 15;280(28):26457-66 [15899893] EMBO J. 2005 Oct 19;24(20):3635-46 [16193063] J Pharmacol Exp Ther. 2006 Feb;316(2):835-42 [16249370] Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3615-20 [16505382] J Mol Biol. 2007 Jun 15;369(4):895-901 [17481657] Trends Neurosci. 1999 Dec;22(12):555-61 [10542436] J Biol Chem. 2000 Feb 25;275(8):5620-5 [10681544] Annu Rev Pharmacol Toxicol. 2000;40:431-58 [10836143] Protein Sci. 2000 May;9(5):886-97 [10850798] Bioinformatics. 2000 Jun;16(6):566-7 [10980157] Nature. 2001 May 17;411(6835):269-76 [11357122] J Biol Chem. 2001 Jan 26;276(4):2417-26 [11056174] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3210-5 [11867716] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3216-21 [11867717] Acta Neurol Scand Suppl. 2006;185:15-20 [16866906] J Pharmacol Exp Ther. 2006 Sep;318(3):956-65 [16740622] Biochem Pharmacol. 2006 Sep 14;72(6):661-70 [16716265] Biochem Soc Trans. 2006 Dec;34(Pt 6):1037-40 [17073745] J Mol Neurosci. 2006;30(1-2):101-2 [17192647] J Neurobiol. 2002 Dec;53(4):512-23 [12436416] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Administration of a CD25-directed immunotoxin, LMB-2, to patients with metastatic melanoma induces a selective partial reduction in regulatory T cells in vivo. AN - 68286200; 17878392 AB - CD25+ CD4+ T regulatory (Treg) cells regulate peripheral self tolerance and possess the ability to suppress antitumor responses, which may in part explain the poor clinical response of cancer patients undergoing active immunization protocols. We have previously shown that in vitro incubation of human PBMC with LMB-2, a CD25-directed immunotoxin, significantly reduced CD25+ FOXP3+ CD4+ Treg cells without impairing the function of the remaining lymphocytes. In the current study, eight patients with metastatic melanoma were treated with LMB-2 followed by MART-1 and gp100-specific peptide vaccination. LMB-2 administration resulted in a preferential, transient reduction in mean circulating CD25+ CD4+ T cell number, from 83 +/- 16 cells/microl to a nadir of 17 +/- 5 cells/microl, a 79.1% reduction. FOXP3 analysis revealed a less robust depletion with mean FOXP3+ CD4+ Treg cell number decreasing from 74 +/- 15 cells/microl to 36 +/- 8 cells/microl, a 51.4% reduction. FOXP3+ CD4+ Treg cells that survived LMB-2-mediated cytotoxicity expressed little or no CD25. Similar to the peripheral blood, immunohistochemical analysis showed a 68.9% mean reduction in FOXP3+ CD4+ Treg cell frequency in evaluable lesions. Despite inducing a reduction in Treg cell numbers in vivo, LMB-2 therapy did not augment the immune response to cancer vaccination and no patient experienced an objective response or autoimmunity. These data demonstrate the capacity of a CD25-directed immunotoxin to selectively mediate a transient partial reduction in circulating and tumor-infiltrating Treg cells in vivo, and suggest that more comprehensive Treg cell elimination may be required to bolster antitumor responses in patients with metastatic melanoma. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Powell, Daniel J AU - Felipe-Silva, Aloisio AU - Merino, Maria J AU - Ahmadzadeh, Mojgan AU - Allen, Tamika AU - Levy, Catherine AU - White, Donald E AU - Mavroukakis, Sharon AU - Kreitman, Robert J AU - Rosenberg, Steven A AU - Pastan, Ira AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Daniel_Powell@nih.gov Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 4919 EP - 4928 VL - 179 IS - 7 SN - 0022-1767, 0022-1767 KW - Antibodies, Monoclonal KW - 0 KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Exotoxins KW - FOXP3 protein, human KW - Forkhead Transcription Factors KW - Immunotoxins KW - Interleukin-2 Receptor alpha Subunit KW - Peptides KW - Abridged Index Medicus KW - Index Medicus KW - Neoplasm Metastasis -- immunology KW - Exotoxins -- administration & dosage KW - Humans KW - Peptides -- immunology KW - Exotoxins -- immunology KW - Vaccination KW - Exotoxins -- pharmacokinetics KW - Neoplasm Metastasis -- drug therapy KW - Treatment Outcome KW - Middle Aged KW - Neoplasm Metastasis -- pathology KW - Exotoxins -- therapeutic use KW - Forkhead Transcription Factors -- metabolism KW - Female KW - Male KW - Immunotoxins -- pharmacokinetics KW - T-Lymphocytes, Regulatory -- drug effects KW - Immunotoxins -- administration & dosage KW - Melanoma -- metabolism KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Melanoma -- pathology KW - Antibodies, Monoclonal -- pharmacokinetics KW - Immunotoxins -- immunology KW - T-Lymphocytes, Regulatory -- cytology KW - Melanoma -- drug therapy KW - Immunotoxins -- therapeutic use KW - Interleukin-2 Receptor alpha Subunit -- immunology KW - T-Lymphocytes, Regulatory -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68286200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Administration+of+a+CD25-directed+immunotoxin%2C+LMB-2%2C+to+patients+with+metastatic+melanoma+induces+a+selective+partial+reduction+in+regulatory+T+cells+in+vivo.&rft.au=Powell%2C+Daniel+J%3BFelipe-Silva%2C+Aloisio%3BMerino%2C+Maria+J%3BAhmadzadeh%2C+Mojgan%3BAllen%2C+Tamika%3BLevy%2C+Catherine%3BWhite%2C+Donald+E%3BMavroukakis%2C+Sharon%3BKreitman%2C+Robert+J%3BRosenberg%2C+Steven+A%3BPastan%2C+Ira&rft.aulast=Powell&rft.aufirst=Daniel&rft.date=2007-10-01&rft.volume=179&rft.issue=7&rft.spage=4919&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-06 N1 - Date created - 2007-09-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2005 Mar 1;174(5):2661-70 [15728473] J Immunol. 2005 Mar 1;174(5):2591-601 [15728465] Immunity. 2005 Mar;22(3):329-41 [15780990] Nat Immunol. 2005 Apr;6(4):345-52 [15785760] J Exp Med. 2005 May 16;201(10):1591-602 [15883172] Science. 2005 Aug 26;309(5739):1380-4 [16123302] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] J Clin Invest. 2005 Oct;115(10):2904-13 [16167085] J Immunother. 2005 Nov-Dec;28(6):582-92 [16224276] J Immunol. 2005 Nov 1;175(9):6169-76 [16237114] J Immunol. 2005 Dec 1;175(11):7746-54 [16301685] J Clin Invest. 2005 Dec;115(12):3623-33 [16308572] Nature. 2006 Feb 9;439(7077):682-7 [16382236] J Immunother. 2006 Mar-Apr;29(2):208-14 [16531821] Nat Rev Immunol. 2006 Apr;6(4):295-307 [16557261] J Immunol. 2006 May 1;176(9):5255-66 [16621991] Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6659-64 [16617117] J Immunother. 2006 Jul-Aug;29(4):455-63 [16799341] Cancer Res. 2007 Jan 1;67(1):371-80 [17210720] Clin Immunol. 2007 Apr;123(1):18-29 [17185041] Int J Cancer. 2007 Jun 15;120(12):2723-33 [17315189] J Immunol. 2004 Jul 15;173(2):1444-53 [15240741] J Immunol. 1999 Dec 1;163(11):6292-300 [10570323] Leukemia. 2000 Jan;14(1):129-35 [10637488] J Clin Oncol. 2000 Apr;18(8):1622-36 [10764422] J Immunol. 2000 Aug 15;165(4):2287-96 [10925318] Nat Genet. 2001 Jan;27(1):20-1 [11137993] Eur J Immunol. 2002 Mar;32(3):731-41 [11870617] J Immunol. 2002 Jun 15;168(12):5979-83 [12055202] Cytotherapy. 2002;4(5):395-406 [12473206] J Immunother. 2003 Jan-Feb;26(1):85-93 [12514432] Eur J Immunol. 2002 Nov;32(11):3267-75 [12555672] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Clin Invest. 2003 Nov;112(9):1437-43 [14597769] J Immunother. 2004 Jan-Feb;27(1):36-47 [14676632] Immunity. 2004 Jan;20(1):107-18 [14738769] Clin Cancer Res. 2004 Jan 15;10(2):668-80 [14760090] Biol Blood Marrow Transplant. 2004 Aug;10(8):552-60 [15282533] Nat Rev Immunol. 2004 Aug;4(8):595-602 [15286726] Nat Med. 2004 Sep;10(9):942-9 [15322536] Nat Med. 2004 Sep;10(9):909-15 [15340416] Eur J Immunol. 1990 Apr;20(4):785-91 [2140788] Bioconjug Chem. 1993 Nov-Dec;4(6):581-5 [8305530] Cancer Res. 1994 Aug 15;54(16):4362-70 [8044783] Cancer Res. 1995 Jan 15;55(2):318-23 [7812965] Bioconjug Chem. 1993 Mar-Apr;4(2):112-20 [7873642] Science. 1995 Jun 9;268(5216):1472-6 [7770771] Immunity. 1995 Oct;3(4):521-30 [7584142] Cancer Res. 1996 Oct 15;56(20):4749-57 [8840994] Cancer J Sci Am. 1997 Jan-Feb;3(1):37-44 [9072306] Nat Med. 1998 Mar;4(3):321-7 [9500606] J Exp Med. 1999 Sep 6;190(5):705-15 [10477554] J Clin Invest. 2005 Mar;115(3):739-46 [15696196] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson's disease. AN - 68276309; 17681816 AB - Parkinson's disease involves loss of dopamine (DA)-producing neurons in the substantia nigra, associated with fewer pre-synaptic DA transporters (DATs) but more post-synaptic dopaminergic D2 receptors in terminal areas of these neurons. Arachidonic acid (AA) signaling via post-synaptic D2 receptors coupled to cytosolic phospholipase A2 (cPLA2) will be reduced in terminal areas ipsilateral to a chronic unilateral substantia nigra lesion in rats given D-amphetamine, which reverses the direction of the DAT, but will be increased in rats given quinpirole, a D2-receptor agonist. D-amphetamine (5.0 mg/kg i.p.), quinpirole (1.0 mg/kg i.v.), or saline was administered to unanesthetized rats having a chronic unilateral lesion of the substantia nigra. AA incorporation coefficients, k* (radioactivity/integrated plasma radioactivity), markers of AA signaling, were measured using quantitative autoradiography in 62 bilateral brain regions following intravenous [1-(14)C]AA. In rats given saline (baseline), k* was elevated in 13 regions in the lesioned compared with intact hemisphere. Quinpirole increased k* in frontal cortical and basal ganglia regions bilaterally, more so in the lesioned than intact hemisphere. D-amphetamine increased k* bilaterally but less so in the lesioned hemisphere. Increased baseline elevations of k* and increased responsiveness to quinpirole in the lesioned hemisphere are consistent with their higher D2-receptor and cPLA2 activity levels, whereas reduced responsiveness to D-amphetamine is consistent with dropout of pre-synaptic elements containing the DAT. In vivo imaging of AA signaling using dopaminergic drugs can identify pre- and post-synaptic DA changes in animal models of Parkinson's disease. JF - NeuroImage AU - Bhattacharjee, Abesh Kumar AU - Meister, Lindsey M AU - Chang, Lisa AU - Bazinet, Richard P AU - White, Laura AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg. 9, Room 1S126, Bethesda, MD 20892, USA. abesh@mail.nih.gov Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 1112 EP - 1121 VL - 37 IS - 4 SN - 1053-8119, 1053-8119 KW - Dopamine Agonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Hydroxydopamines KW - Radiopharmaceuticals KW - Receptors, Presynaptic KW - Sympatholytics KW - Quinpirole KW - 20OP60125T KW - Arachidonic Acid KW - 27YG812J1I KW - Dextroamphetamine KW - TZ47U051FI KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Infusions, Intra-Arterial KW - Body Temperature -- drug effects KW - Infusions, Intravenous KW - Algorithms KW - Autoradiography KW - Dextroamphetamine -- pharmacology KW - Rats KW - Heart Rate -- drug effects KW - Quinpirole -- pharmacology KW - Dopamine Agonists -- pharmacology KW - Blood Pressure -- drug effects KW - Signal Transduction KW - Parkinson Disease, Secondary -- physiopathology KW - Arachidonic Acid -- physiology KW - Parkinson Disease, Secondary -- chemically induced KW - Synapses -- physiology KW - Parkinson Disease, Secondary -- pathology KW - Synapses -- drug effects KW - Receptors, Presynaptic -- physiology KW - Dopamine -- physiology KW - Arachidonic Acid -- administration & dosage KW - Receptors, Presynaptic -- drug effects KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68276309?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=In+vivo+imaging+of+disturbed+pre-+and+post-synaptic+dopaminergic+signaling+via+arachidonic+acid+in+a+rat+model+of+Parkinson%27s+disease.&rft.au=Bhattacharjee%2C+Abesh+Kumar%3BMeister%2C+Lindsey+M%3BChang%2C+Lisa%3BBazinet%2C+Richard+P%3BWhite%2C+Laura%3BRapoport%2C+Stanley+I&rft.aulast=Bhattacharjee&rft.aufirst=Abesh&rft.date=2007-10-01&rft.volume=37&rft.issue=4&rft.spage=1112&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - JOUR T1 - Two-color lymphatic mapping using Ig-conjugated near infrared optical probes. AN - 68272917; 17522707 AB - To map the drainage patterns of the lymphatic system, multicolor optical probes must be developed, which can be interstitially administered. These agents must be of sufficient size to be retained by the lymphatic system and permit the conjugation or incorporation of fluorescent probes with varying emission wavelengths. Quantum dots fulfill these criteria, but their potential toxicity limits their application to research settings. Here, we describe the synthesis of lymphatic optical probes based on Igs conjugated with Cy5.5 and Cy7 and demonstrate in animal models that these agents can map the lymphatic drainage patterns within axillary nodes draining both the breast and upper extremity, cervical nodes draining both the ear and upper extremity, and sentinel lymph nodes draining different anatomic locations. The ability to separately and simultaneously visualize the drainage patterns from two separate lymphatic vessels may have implications for the preoperative mapping of lymph nodes before lymph node resection. The biocompatibility of fluorescently labeled Igs in comparison to other nanoparticulate fluorophores improves the chances of clinical translation. This noninvasive and biocompatible multicolor method of optical lymphangiography may elucidate the complex human lymphatic system and reduce the risk of lymphedema after surgery for melanoma and other cancers. JF - The Journal of investigative dermatology AU - Hama, Yukihiro AU - Koyama, Yoshinori AU - Urano, Yasuteru AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1088, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2351 EP - 2356 VL - 127 IS - 10 KW - Biocompatible Materials KW - 0 KW - Fluorescent Dyes KW - Immunoglobulin G KW - Index Medicus KW - Models, Animal KW - Animals KW - Lymph Nodes -- pathology KW - Mice KW - Mice, Nude KW - Lymphedema -- etiology KW - Sentinel Lymph Node Biopsy -- methods KW - Color KW - Diagnostic Imaging -- methods KW - Risk Factors KW - Lymphedema -- pathology KW - Lymphedema -- diagnosis KW - Lymphography -- methods KW - Infrared Rays KW - Lymphography -- adverse effects KW - Lymphatic System -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68272917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=Two-color+lymphatic+mapping+using+Ig-conjugated+near+infrared+optical+probes.&rft.au=Hama%2C+Yukihiro%3BKoyama%2C+Yoshinori%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-10-01&rft.volume=127&rft.issue=10&rft.spage=2351&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=1523-1747&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-02 N1 - Date created - 2007-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical safety of a viral vector based prostate cancer vaccine strategy. AN - 68259104; 17707059 AB - The primary objective of this phase I study was to evaluate the clinical safety of a vaccine using recombinant vaccinia virus (prime) and recombinant fowlpox virus (boost) in combination with granulocyte-macrophage colony-stimulating factor in patients with prostate cancer. The vaccines contained transgenes for prostate specific antigen, a triad of co-stimulatory molecules and a tumor antigen whose amino acid sequence had been modified to enhance its immunogenicity. Secondary end points were immunological and clinical responses, changes in prostate specific antigen velocity, and the kinetics of vaccinia virus clearance from the vaccination site, serum, peripheral blood mononuclear cells, urine and saliva. The 15 patients enrolled in this study had metastatic prostate cancer. Patients were given recombinant fowlpox-prostate specific antigen/triad of co-stimulatory molecules alone or recombinant vaccinia-prostate specific antigen/triad of co-stimulatory molecules followed by recombinant fowlpox-prostate specific antigen/triad of co-stimulatory molecules on a prime and boost schedule with or without recombinant-granulocyte-macrophage colony-stimulating factor protein or recombinant fowlpox-granulocyte-macrophage colony-stimulating factor vector. Prostate specific antigen specific immune responses were measured using an enzyme-linked immunosorbent spot assay for interferon-gamma production. Polymerase chain reaction for vaccinia DNA and a plaque assay for live virus were also used. Some grade 2 toxicity was seen in patients who received a higher dose of recombinant fowlpox-granulocyte-macrophage colony-stimulating factor but no toxicity exceeded grade 2. Viable vaccinia was detected after vaccination at the site swab of 1 of 4 patients analyzed. Prostate specific antigen specific immune responses were seen in 4 of 6 patients who were HLA-A2+ and decreases in serum prostate specific antigen velocity were observed in 9 of 15. Based on the safety and preliminary immunogenicity results of this trial we recommend initiating a randomized, phase II study of prostate specific antigen/triad of co-stimulatory molecules vaccines in patients with less advanced prostate cancer. JF - The Journal of urology AU - Arlen, Philip M AU - Skarupa, Lisa AU - Pazdur, Mary AU - Seetharam, Mahesh AU - Tsang, Kwong Y AU - Grosenbach, Douglas W AU - Feldman, Jarett AU - Poole, Diane J AU - Litzinger, Mary AU - Steinberg, Seth M AU - Jones, Elizabeth AU - Chen, Clara AU - Marte, Jennifer AU - Parnes, Howard AU - Wright, John AU - Dahut, William AU - Schlom, Jeffrey AU - Gulley, James L AD - Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1515 EP - 1520 VL - 178 IS - 4 Pt 1 SN - 0022-5347, 0022-5347 KW - Cancer Vaccines KW - 0 KW - Vaccines, Synthetic KW - rF-TRICOM vaccine KW - Granulocyte-Macrophage Colony-Stimulating Factor KW - 83869-56-1 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Abridged Index Medicus KW - Index Medicus KW - Aged, 80 and over KW - Humans KW - Prostate-Specific Antigen -- immunology KW - Prostate-Specific Antigen -- genetics KW - Disease Progression KW - Aged KW - Middle Aged KW - Immunization, Secondary KW - Immunization Schedule KW - Male KW - Vaccinia virus -- genetics KW - Vaccinia virus -- immunology KW - Granulocyte-Macrophage Colony-Stimulating Factor -- immunology KW - Prostatic Neoplasms -- immunology KW - Cancer Vaccines -- adverse effects KW - Cancer Vaccines -- therapeutic use KW - Vaccines, Synthetic -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Granulocyte-Macrophage Colony-Stimulating Factor -- therapeutic use KW - Cancer Vaccines -- immunology KW - Cancer Vaccines -- genetics KW - Granulocyte-Macrophage Colony-Stimulating Factor -- genetics KW - Vaccines, Synthetic -- immunology KW - Vaccines, Synthetic -- genetics KW - Vaccines, Synthetic -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68259104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+urology&rft.atitle=Clinical+safety+of+a+viral+vector+based+prostate+cancer+vaccine+strategy.&rft.au=Arlen%2C+Philip+M%3BSkarupa%2C+Lisa%3BPazdur%2C+Mary%3BSeetharam%2C+Mahesh%3BTsang%2C+Kwong+Y%3BGrosenbach%2C+Douglas+W%3BFeldman%2C+Jarett%3BPoole%2C+Diane+J%3BLitzinger%2C+Mary%3BSteinberg%2C+Seth+M%3BJones%2C+Elizabeth%3BChen%2C+Clara%3BMarte%2C+Jennifer%3BParnes%2C+Howard%3BWright%2C+John%3BDahut%2C+William%3BSchlom%2C+Jeffrey%3BGulley%2C+James+L&rft.aulast=Arlen&rft.aufirst=Philip&rft.date=2007-10-01&rft.volume=178&rft.issue=4+Pt+1&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+urology&rft.issn=00225347&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-19 N1 - Date created - 2007-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dark matter in a deep-sea vent and in human mouth. AN - 68245622; 17803764 JF - Environmental microbiology AU - Galperin, Michael Y AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. galperin@ncbi.nlm.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 2385 EP - 2391 VL - 9 IS - 10 SN - 1462-2912, 1462-2912 KW - Sewage KW - 0 KW - Index Medicus KW - Rhodophyta -- genetics KW - Sewage -- microbiology KW - Humans KW - Upper Gastrointestinal Tract -- microbiology KW - Genomics -- methods KW - Genome, Bacterial KW - Seawater -- microbiology KW - Water Microbiology KW - Mouth -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68245622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+microbiology&rft.atitle=Dark+matter+in+a+deep-sea+vent+and+in+human+mouth.&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2007-10-01&rft.volume=9&rft.issue=10&rft.spage=2385&rft.isbn=&rft.btitle=&rft.title=Environmental+microbiology&rft.issn=14622912&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-09-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Appl Environ Microbiol. 2001 Jan;67(1):411-9 [11133473] PLoS Biol. 2007 Jul;5(7):e156 [17579514] Genome Biol. 2001;2(12):RESEARCH0051 [11790254] Int J Syst Evol Microbiol. 2002 May;52(Pt 3):933-8 [12054260] Microbiology. 2002 Jul;148(Pt 7):2097-109 [12101298] J Clin Microbiol. 2003 Feb;41(2):558-63 [12574246] Appl Environ Microbiol. 2003 Mar;69(3):1687-94 [12620860] Environ Microbiol. 2003 Oct;5(10):961-76 [14510850] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4250-5 [15016918] Nature. 2004 Apr 8;428(6983):653-7 [15071595] Appl Environ Microbiol. 2004 Sep;70(9):5595-602 [15345448] Int J Syst Bacteriol. 1997 Oct;47(4):1118-23 [9336917] Int J Syst Bacteriol. 1999 Jan;49 Pt 1:207-16 [10028265] FEMS Microbiol Lett. 1999 May 15;174(2):247-50 [10339815] Nature. 1999 May 27;399(6734):323-9 [10360571] Ann Periodontol. 2002 Dec;7(1):8-16 [16013212] Environ Microbiol. 2005 Oct;7(10):1619-32 [16156735] Nucleic Acids Res. 2006;34(1):1-9 [16397293] Environ Microbiol. 2006 Jun;8(6):956-70 [16689717] J Bacteriol. 2006 Jun;188(11):4024-36 [16707694] Nat Rev Microbiol. 2006 Oct;4(10):784-90 [16953248] Science. 2007 Feb 2;315(5812):666-9 [17272727] Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7116-21 [17438286] Mol Microbiol. 2007 May;64(4):881-5 [17501914] Proc Natl Acad Sci U S A. 2007 May 15;104 Suppl 1:8669-76 [17494747] Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10643-8 [17563350] BMC Genomics. 2007;8:162 [17565669] Extremophiles. 2006 Dec;10(6):505-13 [16738814] Microb Ecol. 2007 Jul;54(1):101-11 [17364249] Curr Biol. 2007 Jul 3;17(13):R510-2 [17610831] Nat Biotechnol. 2007 Jul;25(7):763-9 [17592475] BMC Bioinformatics. 2007;8:225 [17597547] Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12146-50 [17615243] Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11889-94 [17620602] Science. 2007 Aug 3;317(5838):632-8 [17600181] BMC Biol. 2007;5:28 [17623057] PLoS Genet. 2007 Aug;3(8):e138 [17722982] Nat Biotechnol. 2007 Sep;25(9):1007-14 [17704766] Nat Rev Microbiol. 2007 Nov;5(11):892-9 [17938630] Chem Biol Interact. 2008 Jan 30;171(2):236-49 [17434157] Appl Environ Microbiol. 2001 Mar;67(3):1210-7 [11229912] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Absence of Smad3 confers radioprotection through modulation of ERK-MAPK in primary dermal fibroblasts. AN - 68202948; 17624738 AB - Transforming growth factor-beta1 (TGF-beta1), a key biological mediator following ionizing radiation, plays a role in a complex tissue reaction involved in local radiation-induced pathological damage. Knocking out Smad3 (S3KO), a downstream signaling intermediate in the TGF-beta pathway, in mice protects their skin from radiation damage as demonstrated by decreased epithelial acanthosis and dermal fibrosis as compared to Smad3 wild-type (S3WT) mice. The present study was designed to investigate the molecular mechanisms contributing to increased radioprotection in the absence of Smad3. Primary dermal fibroblasts derived from S3WT and KO mice were exposed to 5Gy ionizing radiation in vitro. Western blot analyses, immunocytochemistry, and reporter transfections were used to dissect the radiation-induced events. There was increased phosphorylation of ERK-MAPK, p53 and H2A.X in S3KO compared to the S3WT fibroblasts, implicating them in a key signaling cascade in response of these cells to radiation. Pro-fibrotic gene expression was decreased in S3KO fibroblasts post-irradiation. The absence of Smad3 may decrease radio-responsiveness by increasing activation of DNA damage sensing mechanisms and decreasing induction of pro-fibrotic genes. JF - Journal of dermatological science AU - Arany, Praveen R AU - Flanders, Kathleen C AU - DeGraff, William AU - Cook, John AU - Mitchell, James B AU - Roberts, Anita B AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. arany@fas.harvard.edu Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 35 EP - 42 VL - 48 IS - 1 SN - 0923-1811, 0923-1811 KW - H2AX protein, mouse KW - 0 KW - Histones KW - Smad3 Protein KW - Smad3 protein, mouse KW - Tumor Suppressor Protein p53 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Animals KW - Cell Proliferation -- radiation effects KW - Transfection KW - Cells, Cultured KW - Radiation Injuries -- prevention & control KW - Histones -- metabolism KW - Mice KW - DNA Damage -- radiation effects KW - Tumor Suppressor Protein p53 -- metabolism KW - Mice, Knockout KW - Dermis -- cytology KW - Smad3 Protein -- metabolism KW - Fibroblasts -- radiation effects KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Fibroblasts -- metabolism KW - Smad3 Protein -- genetics KW - Radiation, Ionizing UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68202948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+dermatological+science&rft.atitle=Absence+of+Smad3+confers+radioprotection+through+modulation+of+ERK-MAPK+in+primary+dermal+fibroblasts.&rft.au=Arany%2C+Praveen+R%3BFlanders%2C+Kathleen+C%3BDeGraff%2C+William%3BCook%2C+John%3BMitchell%2C+James+B%3BRoberts%2C+Anita+B&rft.aulast=Arany&rft.aufirst=Praveen&rft.date=2007-10-01&rft.volume=48&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Journal+of+dermatological+science&rft.issn=09231811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-27 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Pathol. 2003 Dec;163(6):2247-57 [14633599] Science. 2004 Feb 6;303(5659):848-51 [14764882] Trends Cell Biol. 2004 Mar;14(3):107-11 [15055198] Int J Radiat Oncol Biol Phys. 1994 Oct 15;30(3):671-6 [7928499] Radiat Res. 1997 Feb;147(2):245-56 [9008217] Cell. 1997 Jun 27;89(7):1175-84 [9215639] FASEB J. 1997 Oct;11(12):991-1002 [9337152] Cell. 1997 Oct 31;91(3):325-34 [9363941] Am J Pathol. 1998 Nov;153(5):1531-40 [9811345] J Biol Chem. 1998 Dec 4;273(49):33048-53 [9830059] Int J Cancer. 1999 Apr 20;84(2):155-9 [10096248] J Biol Chem. 2004 Nov 12;279(46):47455-63 [15345715] J Cell Biochem. 2005 Jun 1;95(3):611-9 [15832344] Mutat Res. 2006 May 11;597(1-2):32-8 [16417910] Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9250-5 [16754864] Radiat Res. 2006 Jun;165(6):671-7 [16802867] Cancer Res. 2000 Mar 1;60(5):1254-60 [10728684] Nature. 2003 Oct 9;425(6958):577-84 [14534577] Oncogene. 2003 Sep 1;22(37):5885-96 [12947395] Int J Radiat Biol. 2003 May;79(5):351-8 [12943243] Cell. 2003 Aug 8;114(3):371-83 [12914701] Cancer Res. 2003 Aug 1;63(15):4347-50 [12907603] Nat Cell Biol. 2003 Jul;5(7):675-9 [12792649] Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95 [10959836] Radiat Res. 2003 Mar;159(3):283-300 [12600231] Cancer Res. 2002 Oct 15;62(20):5627-31 [12384514] Int J Radiat Oncol Biol Phys. 1996 Jan 1;34(1):251-66 [12118559] Am J Pathol. 2002 Mar;160(3):1057-68 [11891202] Radiat Res. 2001 Apr;155(4):543-53 [11260656] Int J Radiat Oncol Biol Phys. 2001 Feb 1;49(2):353-65 [11173128] J Biol Chem. 2000 Jul 7;275(27):20444-9 [10781582] EMBO J. 1999 Dec 15;18(24):7002-10 [10601022] J Biol Chem. 2003 Mar 21;278(12):10304-13 [12525489] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - MAC1 mediates LPS-induced production of superoxide by microglia: the role of pattern recognition receptors in dopaminergic neurotoxicity. AN - 68133410; 17654704 AB - Microglia-derived superoxide is critical for the inflammation-induced selective loss of dopaminergic (DA) neurons, but the underlying mechanisms of microglial activation remain poorly defined. Using neuron-glia and microglia-enriched cultures from mice deficient in the MAC1 receptor (MAC1-/-), we demonstrate that lipopolysaccharide (LPS) treatment results in lower TNFalpha response, attenuated loss of DA neurons, and absence of extracellular superoxide production in MAC1-/- cultures. Microglia accumulated fluorescently labeled LPS in punctate compartments associated with the plasma membrane, intracellular vesicles, and the Golgi apparatus. Cytochalasin D (CD), an inhibitor of phagocytosis, blocked LPS internalization. However, microglia derived from Toll-like receptor 4 deficient mice and MAC1-/- mice failed to show a significant decrease in intracellular accumulation of labeled LPS, when compared with controls. Pretreatment with the scavenger receptor inhibitor, fucoidan, inhibited 79% of LPS accumulation in microglia without affecting superoxide, indicating that LPS internalization and superoxide production are mediated by separate phagocytosis receptors. Together, these data demonstrate that MAC1 is essential for LPS-induced superoxide from microglia, implicating MAC1 as a critical trigger of microglial-derived oxidative stress during inflammation-mediated neurodegeneration. Copyright (c) 2007 Wiley-Liss, Inc. JF - Glia AU - Pei, Zhong AU - Pang, Hao AU - Qian, Li AU - Yang, Sufen AU - Wang, Tonggauang AU - Zhang, Wei AU - Wu, Xeufei AU - Dallas, Shannon AU - Wilson, Belinda AU - Reece, Jeffrey M AU - Miller, David S AU - Hong, Jau-Shyong AU - Block, Michelle L AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1362 EP - 1373 VL - 55 IS - 13 SN - 0894-1491, 0894-1491 KW - Lipopolysaccharides KW - 0 KW - Macrophage-1 Antigen KW - Membrane Glycoproteins KW - Neurotoxins KW - Reactive Oxygen Species KW - Receptors, Pattern Recognition KW - Receptors, Scavenger KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Superoxides KW - 11062-77-4 KW - Cybb protein, mouse KW - EC 1.6.3.1 KW - NADPH Oxidase KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - NADPH Oxidase -- metabolism KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Receptors, Scavenger -- metabolism KW - Mice KW - Mice, Knockout KW - Neuroglia -- metabolism KW - Cells, Cultured KW - Mice, Inbred C3H KW - Mice, Inbred C57BL KW - Toll-Like Receptor 4 -- metabolism KW - Female KW - Male KW - Membrane Glycoproteins -- metabolism KW - Superoxides -- metabolism KW - Microglia -- physiology KW - Neurons -- metabolism KW - Macrophage-1 Antigen -- physiology KW - Neurons -- drug effects KW - Lipopolysaccharides -- pharmacology KW - Lipopolysaccharides -- metabolism KW - Receptors, Pattern Recognition -- metabolism KW - Neurotoxins -- pharmacology KW - Dopamine -- metabolism KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68133410?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Glia&rft.atitle=MAC1+mediates+LPS-induced+production+of+superoxide+by+microglia%3A+the+role+of+pattern+recognition+receptors+in+dopaminergic+neurotoxicity.&rft.au=Pei%2C+Zhong%3BPang%2C+Hao%3BQian%2C+Li%3BYang%2C+Sufen%3BWang%2C+Tonggauang%3BZhang%2C+Wei%3BWu%2C+Xeufei%3BDallas%2C+Shannon%3BWilson%2C+Belinda%3BReece%2C+Jeffrey+M%3BMiller%2C+David+S%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Pei&rft.aufirst=Zhong&rft.date=2007-10-01&rft.volume=55&rft.issue=13&rft.spage=1362&rft.isbn=&rft.btitle=&rft.title=Glia&rft.issn=08941491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-08-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toll-like receptors in inflammation, infection and cancer. AN - 68118899; 17673142 AB - Members of the Toll-like receptor (TLR) family play key roles in both innate and adaptive immune responses. TLR proteins enable host to recognize a large number of pathogen-associated molecular patterns such as bacterial lipopolysaccharides, viral RNA, CPG-containing DNA, and flagellin, among others. TLRs are also apparently able to mediate responses to host molecules, including one defensin, ROS, HMGB1 (high-mobility group box protein 1), surfactant protein A, fibrinogen, breakdown products of tissue matrix, heat shock proteins (hsp) and eosinophil-derived neurotoxin (EDN). Thus, TLR are involved in the development of many pathological conditions including infectious diseases, tissue damage, autoimmune and neurodegenerative diseases and cancer. In this review, the contribution of TLRs to diseases of the central nervous system (CNS), lung, gastrointestinal tract, kidney and skin as well as cancer is evaluated. We hope to provide new insight into the pathogenesis and progression of diseases and more importantly, into the potential for TLRs as targets of therapeutics. JF - International immunopharmacology AU - Chen, Keqiang AU - Huang, Jian AU - Gong, Wanghua AU - Iribarren, Pablo AU - Dunlop, Nancy M AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. kchen@mail.ncifcrf.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1271 EP - 1285 VL - 7 IS - 10 SN - 1567-5769, 1567-5769 KW - Ligands KW - 0 KW - Toll-Like Receptors KW - Index Medicus KW - Animals KW - Humans KW - Virus Diseases -- immunology KW - Bacterial Infections -- immunology KW - Toll-Like Receptors -- immunology KW - Inflammation -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68118899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+immunopharmacology&rft.atitle=Toll-like+receptors+in+inflammation%2C+infection+and+cancer.&rft.au=Chen%2C+Keqiang%3BHuang%2C+Jian%3BGong%2C+Wanghua%3BIribarren%2C+Pablo%3BDunlop%2C+Nancy+M%3BWang%2C+Ji+Ming&rft.aulast=Chen&rft.aufirst=Keqiang&rft.date=2007-10-01&rft.volume=7&rft.issue=10&rft.spage=1271&rft.isbn=&rft.btitle=&rft.title=International+immunopharmacology&rft.issn=15675769&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-30 N1 - Date created - 2007-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Body Dissatisfaction, Living Away from Parents, and Poor Social Adjustment Predict Binge Eating Symptoms in Young Women Making the Transition to University AN - 61673899; 200802135 AB - The current study explored how body dissatisfaction and challenges associated with the transition to university predicted symptoms of binge eating. Participants were 101 female full-time first-year university students (M=18.3 years of age; SD=.50) who completed a background questionnaire and a web-based daily checklist assessing binge eating. Hierarchical Generalized Linear Modeling results showed that participants who were more dissatisfied with their bodies were three times as likely to report symptoms of binge eating compared to participants who were less dissatisfied. Participants who lived away from home were three times as likely to report symptoms of binge eating compared to participants living with parents. Finally, poor perceived social adjustment to the university context was associated with an increased likelihood of binge eating. Discussion calls for more research exploring the role that university challenges and adjustment play in predicting eating problems. Adapted from the source document. JF - Journal of Youth and Adolescence AU - Barker, Erin T AU - Galambos, Nancy L AD - Child and Family Research, National Institute of Child Health and Human Development, 6705 Rockledge Drive, Suite 8030, Bethesda, MD 20892-7971, USA barkerer@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 904 EP - 911 PB - Springer, Dordrecht, The Netherlands VL - 36 IS - 7 SN - 0047-2891, 0047-2891 KW - Undergraduate Students KW - Body Image KW - Life Stage Transitions KW - Females KW - Adjustment KW - Eating Disorders KW - article KW - 0513: culture and social structure; culture (kinship, forms of social organization, social cohesion & integration, & social representations) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61673899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Youth+and+Adolescence&rft.atitle=Body+Dissatisfaction%2C+Living+Away+from+Parents%2C+and+Poor+Social+Adjustment+Predict+Binge+Eating+Symptoms+in+Young+Women+Making+the+Transition+to+University&rft.au=Barker%2C+Erin+T%3BGalambos%2C+Nancy+L&rft.aulast=Barker&rft.aufirst=Erin&rft.date=2007-10-01&rft.volume=36&rft.issue=7&rft.spage=904&rft.isbn=&rft.btitle=&rft.title=Journal+of+Youth+and+Adolescence&rft.issn=00472891&rft_id=info:doi/10.1007%2Fs10964-006-9134-6 LA - English DB - Sociological Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - CODEN - JYADA6 N1 - SubjectsTermNotLitGenreText - Eating Disorders; Females; Life Stage Transitions; Undergraduate Students; Body Image; Adjustment DO - http://dx.doi.org/10.1007/s10964-006-9134-6 ER - TY - JOUR T1 - Treatment of Children with Mental Disorders AN - 61381100; 201004933 AB - There has been public concern over reports that very young children are being prescribed psychotropic medications. The studies to date are incomplete, and much more needs to be learned about young children who are treated with medications for all kinds of illnesses. In the field of mental health, new studies are needed to tell us what the best treatments are for children with emotional and behavioral disturbances. Children are in a state of rapid change and growth during their developmental years. Diagnosis and treatment of mental disorders must be viewed with these changes in mind. While some problems are short-lived and don't need treatment, others are persistent and very serious, and parents should seek professional help for their children. This article contains answers to frequently asked questions regarding the treatment of children with mental disorders. Children are in a state of rapid change and growth during their developmental years. Diagnosis and treatment of mental disorders must be viewed with these changes in mind. While some problems are short-lived and don't need treatment, others are persistent and very serious, and parents should seek professional help for their children. This article contains answers to frequently asked questions regarding the treatment of children with mental disorders. Adapted from the source document. JF - Child & Family AU - [Unknown] AD - National Institute of Mental Health (NIH-04-4 702) Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 6 EP - 12 PB - Notre Dame Child & Family Institute, St. Agatha, Ontario, Canada VL - 10 IS - 3 SN - 1206-3177, 1206-3177 KW - Mental Health KW - Parents KW - Mental Illness KW - Children KW - Illness KW - article KW - 6142: mental & emotional health problems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61381100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+%26+Family&rft.atitle=Treatment+of+Children+with+Mental+Disorders&rft.au=%5BUnknown%5D&rft.aulast=%5BUnknown%5D&rft.aufirst=&rft.date=2007-10-01&rft.volume=10&rft.issue=3&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=Child+%26+Family&rft.issn=12063177&rft_id=info:doi/ LA - English DB - Social Services Abstracts N1 - Date revised - 2010-04-07 N1 - Number of references - 5 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Children; Mental Illness; Parents; Illness; Mental Health ER - TY - JOUR T1 - Random effects and latent processes approaches for analyzing binary longitudinal data with missingness: a comparison of approaches using opiate clinical trial data AN - 57248855; 200810628 AB - The analysis of longitudinal data with non-ignorable missingness remains an active area in biostatistics research. This article discusses various random effects and latent process models which have been proposed for analyzing longitudinal binary data subject to both non-ignorable intermittent missing data and dropout. These models account for non-ignorable missingness by introducing random effects or a latent process which is shared between the response model and the model for the missing-data mechanism. We discuss various random effects and latent processes approaches and compare these approaches with analyses from an opiate clinical trial data set, which had high proportion of intermittent missingness and dropout. We also compare these random effect and latent process approaches with other methods for accounting for non-ignorable missingness using this data set. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Albert, Paul S AU - Follmann, Dean A AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, USA albertp@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 417 EP - 439 PB - Hodder Arnold, London UK VL - 16 IS - 5 SN - 0962-2802, 0962-2802 KW - Opiates KW - Clinical information KW - Random effects KW - Accounting KW - Biostatistics KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57248855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Random+effects+and+latent+processes+approaches+for+analyzing+binary+longitudinal+data+with+missingness%3A+a+comparison+of+approaches+using+opiate+clinical+trial+data&rft.au=Albert%2C+Paul+S%3BFollmann%2C+Dean+A&rft.aulast=Albert&rft.aufirst=Paul&rft.date=2007-10-01&rft.volume=16&rft.issue=5&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280206075308 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Random effects; Models; Clinical information; Opiates; Accounting; Biostatistics DO - http://dx.doi.org/10.1177/0962280206075308 ER - TY - JOUR T1 - Rural Populations Are Not Protected From Drug Use and Abuse AN - 57232701; 200809692 AB - The authors provide data and analysis of drug use by geographic region in the U.S., ethnicity, and type of drug. JF - The Journal of Rural Health AU - Thomas, Yonette F AU - Compton, Wilson M AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Bethesda, Md Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1 EP - 3 PB - National Rural Health Association, Kansas City MO VL - 23 IS - s1 SN - 0890-765X, 0890-765X KW - Ethnicity KW - Rural communities KW - Drug abuse KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Rural+Health&rft.atitle=Rural+Populations+Are+Not+Protected+From+Drug+Use+and+Abuse&rft.au=Thomas%2C+Yonette+F%3BCompton%2C+Wilson+M&rft.aulast=Thomas&rft.aufirst=Yonette&rft.date=2007-10-01&rft.volume=23&rft.issue=s1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Rural+Health&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2007.00116.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JRHEEX N1 - SubjectsTermNotLitGenreText - Drug abuse; Rural communities; Substance abuse; Ethnicity DO - http://dx.doi.org/10.1111/j.1748-0361.2007.00116.x ER - TY - JOUR T1 - Bayesian methods for latent trait modelling of longitudinal data AN - 57214439; 200810627 AB - Latent trait models have long been used in the social science literature for studying variables that can only be measured indirectly through multiple items. However, such models are also very useful in accounting for correlation in multivariate and longitudinal data, particularly when outcomes have mixed measurement scales. Bayesian methods implemented with Markov chain Monte Carlo provide a flexible framework for routine fitting of a broad class of latent variable (LV) models, including very general structural equation models. However, in considering LV models, a number of challenging issues arise, including identifiability, confounding between the mean and variance, uncertainty in different aspects of the model, and difficulty in computation. Motivated by the problem of modelling multidimensional longitudinal data, this article reviews the recent literature, provides some recommendations and highlights areas in need of additional research, focusing on methods for model uncertainty. Adapted from the source document. JF - Statistical Methods in Medical Research AU - Dunson, David B AD - Biostatistics Branch, National Institute of Environmental Health Sciences, NC, USA dunson1@niehs.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 399 EP - 415 PB - Hodder Arnold, London UK VL - 16 IS - 5 SN - 0962-2802, 0962-2802 KW - Structural equation models KW - Uncertainty KW - Statistics KW - Social sciences KW - Accounting KW - Modelling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57214439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Statistical+Methods+in+Medical+Research&rft.atitle=Bayesian+methods+for+latent+trait+modelling+of+longitudinal+data&rft.au=Dunson%2C+David+B&rft.aulast=Dunson&rft.aufirst=David&rft.date=2007-10-01&rft.volume=16&rft.issue=5&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Statistical+Methods+in+Medical+Research&rft.issn=09622802&rft_id=info:doi/10.1177%2F0962280206075309 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Uncertainty; Modelling; Accounting; Structural equation models; Social sciences; Statistics DO - http://dx.doi.org/10.1177/0962280206075309 ER - TY - JOUR T1 - Biased Emotional Attention in Post-Traumatic Stress Disorder: A Help As Well As a Hindrance? AN - 57212902; 200808713 AB - Background From a cognitive neuroscience perspective, the emotional attentional bias in post-traumatic stress disorder (PTSD) could be conceptualized either as emotional hyper-responsiveness or as reduced priming of task-relevant representations due to dysfunction in top-down regulatory systems. We investigated these possibilities both with respect to threatening and positive stimuli among traumatized individuals with and without PTSD. Method: Twenty-two patients with PTSD, 21 trauma controls and 20 non- traumatized healthy participants were evaluated on two tasks. For one of these tasks, the affective Stroop task (aST), the emotional stimuli act as distracters and interfere with task performance. For the other, the emotional lexical decision task (eLDT), emotional information facilitates task performance. Results: Compared to trauma controls and healthy participants, patients with PTSD showed increased interference for negative but not positive distracters on the aST and increased emotional facilitation for negative words on the eLDT. Conclusions: These findings document that hyper-responsiveness to threat but not to positive stimuli is specific for patients with PTSD. Adapted from the source document. JF - Psychological Medicine AU - Vythilingam, M AU - Blair, K S AU - McCaffrey, D AU - Scaramozza, M AU - Jones, M AU - Nakic, M AU - Mondillo, K AU - Hadd, K AU - Bonne, O AU - Mitchell, D G V AU - Pine, D S AU - Charney, D S AU - Blair, R J R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 1445 EP - 1455 PB - Cambridge University Press, UK VL - 37 IS - 10 SN - 0033-2917, 0033-2917 KW - Hypersensitivity KW - Posttraumatic stress disorder KW - Attentional bias KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57212902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=Biased+Emotional+Attention+in+Post-Traumatic+Stress+Disorder%3A+A+Help+As+Well+As+a+Hindrance%3F&rft.au=Vythilingam%2C+M%3BBlair%2C+K+S%3BMcCaffrey%2C+D%3BScaramozza%2C+M%3BJones%2C+M%3BNakic%2C+M%3BMondillo%2C+K%3BHadd%2C+K%3BBonne%2C+O%3BMitchell%2C+D+G+V%3BPine%2C+D+S%3BCharney%2C+D+S%3BBlair%2C+R+J+R&rft.aulast=Vythilingam&rft.aufirst=M&rft.date=2007-10-01&rft.volume=37&rft.issue=10&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS003329170700092X LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Posttraumatic stress disorder; Attentional bias; Hypersensitivity DO - http://dx.doi.org/10.1017/S003329170700092X ER - TY - JOUR T1 - Randomized trial of prize-based reinforcement density for simultaneous abstinence from cocaine and heroin AN - 57092654; 200802038 AB - To examine the effect of reinforcer density in prize-based abstinence reinforcement, heroin/cocaine users (N = 116) in methadone maintenance (100 mg/day) were randomly assigned to a noncontingent control group (NonC) or to 1 of 3 groups that earned prize draws for abstinence: manual drawing with standard prize density (MS) or computerized drawing with standard (CS) or high (CH) density. Probabilities (prizes/draw) were standard (50%) and high (78%); prize density was double blind. Mean prize values were CH, $286; CS, $167; MS, $139; and NonC, $171. Outcomes were % opioid/cocaine-negative urines during the 12-week intervention and then 8 weeks postintervention as well as diagnosis of dependence up to 6 months poststudy. CH had significantly more negative specimens than did NonC during intervention and had more than all groups during postintervention treatment: Mean % negative (95% confidence interval) during postintervention treatment adjusted for baseline drug use and dropout were CH, 55% (14%-90%); CS, 7% (1%-27%); MS, 4% (1%-12%); and NonC, 3% (1%-10%). Current cocaine dependence diagnoses after treatment were significantly lower in contingent compared with noncontingent groups. Computerized drawing with higher-density prizes enhanced reduction of cocaine use; abstinence reinforcement had long-term therapeutic benefits. [Copyright 2007 American Psychological Association] JF - Journal of Consulting and Clinical Psychology AU - Ghitza, Udi E AU - Epstein, David H AU - Schmittner, John AU - Vahabzadeh, Massoud AU - Lin, Jia-Ling AU - Preston, Kenzie L AD - Treatment Section, Clinical Pharmacology and Therapeutics Branch, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institute of Health (NIH)/Department of Health and Human Services (DHHS), Baltimore, MD, US Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 765 EP - 774 PB - American Psychological Association, Washington DC VL - 75 IS - 5 SN - 0022-006X, 0022-006X KW - Abstinence KW - Heroin KW - Interventions KW - Reinforcement KW - Cocaine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Consulting+and+Clinical+Psychology&rft.atitle=Randomized+trial+of+prize-based+reinforcement+density+for+simultaneous+abstinence+from+cocaine+and+heroin&rft.au=Ghitza%2C+Udi+E%3BEpstein%2C+David+H%3BSchmittner%2C+John%3BVahabzadeh%2C+Massoud%3BLin%2C+Jia-Ling%3BPreston%2C+Kenzie+L&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-10-01&rft.volume=75&rft.issue=5&rft.spage=765&rft.isbn=&rft.btitle=&rft.title=Journal+of+Consulting+and+Clinical+Psychology&rft.issn=0022006X&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - JCLPBC N1 - SubjectsTermNotLitGenreText - Reinforcement; Abstinence; Cocaine; Heroin; Interventions ER - TY - JOUR T1 - Effect of ketamine anesthesia on daily food intake in Macaca mulatta and Cercopithecus aethiops AN - 36867734; 3534461 AB - Ketamine hydrochloride is frequently administered to non-human primates as a means of chemical restraint. This procedure can be a frequent source of stress to monkeys at research facilities, impacting animal health, well-being and research quality. This study was designed to measure ketamine's effect on daily food intake, a parameter that reflects and influences animal well-being and directly impacts research studies. On five occasions, baseline daily food intake was compared to daily food intake occurring 24, 48, 72, 96, and 120 h after an intra-muscular injection of 10 mg/kg ketamine in male African green monkeys (AGMs) (Cercopithecus aethiops) and male and female rhesus macaques (Macaca mulatta). AGMs and female rhesus macaques had significantly reduced daily food intake during the first 4 days after receiving ketamine. The AGMs continued to display significantly reduced daily food intake on the fifth day after ketamine. The male rhesus macagues showed a trend toward reduced daily food intake, greatest during the first 2 days and remaining less than baseline intake through the fifth day following ketamine. The degree of observed food intake reduction was most severe at the 24 h (mean percent intake reduction: AGMs: 57%; rhesus males: 48%; rhesus females: 40%) and 48 h time points (AGMs: 24%; rhesus males: 14%; rhesus females: 13%). A subset of the AGMs that did not receive ketamine, but observed other animals in the room receive ketamine, showed reduced food intake at 24 and 48 h after ketamine, though not to the degree associated with ketamine administration. These results indicate that ketamine anesthesia is associated with a prolonged reduction in daily food intake in AGMs and rhesus macaques. Frequent use of ketamine in non-human primates may have a significant impact on animal health and well-being, and alternatives to its use warrant consideration. Copyright John Wiley & Sons. Reproduced with permission. An electronic version of this article is available online at http://www.interscience.wiley.com JF - American journal of primatology AU - Springer, Danielle A AU - Baker, Kate C AD - National Institutes of Health, Bethesda ; Tulane National Primate Research Center Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1080 EP - 1092 VL - 69 IS - 10 SN - 0275-2565, 0275-2565 KW - Anthropology KW - Macaques KW - Chemicals KW - Food consumption KW - Physical anthropology KW - Primatology KW - Mental stress KW - Well-being KW - Health KW - Primates KW - Anorexia nervosa UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36867734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+primatology&rft.atitle=Effect+of+ketamine+anesthesia+on+daily+food+intake+in+Macaca+mulatta+and+Cercopithecus+aethiops&rft.au=Springer%2C+Danielle+A%3BBaker%2C+Kate+C&rft.aulast=Springer&rft.aufirst=Danielle&rft.date=2007-10-01&rft.volume=69&rft.issue=10&rft.spage=1080&rft.isbn=&rft.btitle=&rft.title=American+journal+of+primatology&rft.issn=02752565&rft_id=info:doi/10.1002%2Fajp.20421 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9507 1077; 10148; 1053 3617 6220 3547 3545 8808 3849; 7953 7954; 5120 2805 3872 554 971; 5772; 13530 13521; 2175; 10149 DO - http://dx.doi.org/10.1002/ajp.20421 ER - TY - JOUR T1 - Conceptual and methodological issues for research on tobacco-related health disparities AN - 36740852; 3460511 JF - Addiction AU - Fagan, Pebbles AU - Moolchan, Eric T AU - Lawrence, Deirdre AU - Fernander, Anita AU - Ponder, Paris K AU - Velicer, Wayne F AU - Hayward, Mark D AU - King, Gary AU - Shavers, Vickie L AU - Hammons, George J AU - LaVeist, Thomas A AU - Thorpe, Jr., Roland J. AU - Mance, GiShawn A AU - Jackson, John AU - Vallone, Donna AU - Allen, Jane A AU - Clayton, Richard R AU - Xiao, Haijun AU - Stephenson, Michael T AU - Velez, Luis F AU - Chalela, Patricia AU - Ramirez, Amelie AU - Hoyle, Rick H AU - Segress, Melissa J.H. AU - Caudill, Crystal A AU - Tauras, John A AU - Zhu, Shu-Hong AU - Pulvers, Kim AU - Zhuang, Yuerong AU - Báezconde-Garbanati, Lourdes AU - Beebe, Laura A AU - Pérez-Stable, Eliseo J AD - National Cancer Institute, USA ; National Institute on Drug Abuse, Baltimore ; University of Kentucky ; Centers for Disease Control and Prevention, Atlanta ; University of Rhode Island ; University of Texas, Austin ; Pennsylvania State University ; Philander Smith College ; Johns Hopkins University ; American Legacy Foundation, Washington DC ; Texas A&M University ; University of Texas, San Antonio ; Duke University ; University of Illinois, Chicago ; University of California, San Diego ; University of Southern California ; University of Oklahoma ; University of California, San Francisco Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 5 EP - 122 VL - 102 IS - Supp.2 SN - 0965-2140, 0965-2140 KW - Sociology KW - Alcohol KW - Mortality KW - Socioeconomic status KW - Ethnicity KW - Race KW - Health inequality KW - Illness KW - Public health KW - Groups KW - Smoking KW - Genetics KW - Life cycles KW - Education KW - Health care KW - Racial segregation KW - Tobacco KW - Health policy KW - Medical treatment KW - Diseases KW - African-Americans KW - Addiction KW - Ethnic groups UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36740852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Conceptual+and+methodological+issues+for+research+on+tobacco-related+health+disparities&rft.au=Fagan%2C+Pebbles%3BMoolchan%2C+Eric+T%3BLawrence%2C+Deirdre%3BFernander%2C+Anita%3BPonder%2C+Paris+K%3BVelicer%2C+Wayne+F%3BHayward%2C+Mark+D%3BKing%2C+Gary%3BShavers%2C+Vickie+L%3BHammons%2C+George+J%3BLaVeist%2C+Thomas+A%3BThorpe%2C+Jr.%2C+Roland+J.%3BMance%2C+GiShawn+A%3BJackson%2C+John%3BVallone%2C+Donna%3BAllen%2C+Jane+A%3BClayton%2C+Richard+R%3BXiao%2C+Haijun%3BStephenson%2C+Michael+T%3BVelez%2C+Luis+F%3BChalela%2C+Patricia%3BRamirez%2C+Amelie%3BHoyle%2C+Rick+H%3BSegress%2C+Melissa+J.H.%3BCaudill%2C+Crystal+A%3BTauras%2C+John+A%3BZhu%2C+Shu-Hong%3BPulvers%2C+Kim%3BZhuang%2C+Yuerong%3BB%C3%A1ezconde-Garbanati%2C+Lourdes%3BBeebe%2C+Laura+A%3BP%C3%A9rez-Stable%2C+Eliseo+J&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-10-01&rft.volume=102&rft.issue=Supp.2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 11 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5775 13521; 12766 3055 798 10286; 4435; 4049; 4424; 10555 6091; 7396 3245 971; 561 6220; 7890 5792 10484; 5783 5772 6489; 635 1656 10555 6091 961 636 4424; 5676; 3617 6220; 6220; 5460 1615 8573 11325; 8291 3409 6306; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 909; 10449 5772; 5788 11888 10472; 11755 5707 6071 1542 11325; 10571 11441 11814 ER - TY - JOUR T1 - Identifying health disparities across the tobacco continuum AN - 36738712; 3460425 AB - Aims Few frameworks have addressed work-force diversity, inequities and inequalities as part of a comprehensive approach to eliminating tobacco-related health disparities. This paper summarizes the literature and describes the known disparities that exist along the tobacco disease continuum for minority racial and ethnic groups, those living in poverty, those with low education and blue-collar and service workers. The paper also discusses how work-force diversity, inequities in research practice and knowledge allocation and inequalities in access to and quality of health care are fundamental to addressing disparities in health. Methods We examined the available scientific literature and existing public health reports to identify disparities across the tobacco disease continuum by minority racial/ethnic group, poverty status, education level and occupation. Findings Results indicate that differences in risk indicators along the tobacco disease continuum do not explain fully tobacco-related cancer consequences among some minority racial/ethnic groups, particularly among the aggregate groups, blacks/African Americans and American Indians/Alaska Natives. The lack of within-race/ethnic group data and its interactions with socio-economic factors across the life-span contribute to the inconsistency we observe in the disease causal paradigm. Conclusions More comprehensive models are needed to understand the relationships among disparities, social context, diversity, inequalities and inequities. A systematic approach will also help researchers, practitioners, advocates and policy makers determine critical points for interventions, the types of studies and programs needed and integrative approaches needed to eliminate tobacco-related disparities. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Fagan, Pebbles AU - Moolchan, Eric T AU - Lawrence, Deirdre AU - Fernander, Anita AU - Ponder, Paris K AD - National Cancer Institute, USA ; National Institute on Drug Abuse, Baltimore ; University of Kentucky ; Centers for Disease Control and Prevention, Atlanta Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 5 EP - 29 VL - 102 IS - Supp.2 SN - 0965-2140, 0965-2140 KW - Sociology KW - Education KW - Health care KW - Ethnicity KW - Race KW - Tobacco KW - Social problems KW - Diseases KW - Labour force UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36738712?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Identifying+health+disparities+across+the+tobacco+continuum&rft.au=Fagan%2C+Pebbles%3BMoolchan%2C+Eric+T%3BLawrence%2C+Deirdre%3BFernander%2C+Anita%3BPonder%2C+Paris+K&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-10-01&rft.volume=102&rft.issue=Supp.2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01952.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5775 13521; 12766 3055 798 10286; 4435; 10555 6091; 4049; 7143 6074 1952; 3617 6220; 11893 11979 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01952.x ER - TY - JOUR T1 - A biopsychosocial approach to examining tobacco-related health disparities among racially classified social groups AN - 36736853; 3460427 AB - Aims To articulate a broader, multi-causal model that incorporates psychosocial and environmental factors that can differ systematically across racially classified social groups (RCSGs) and impact biological pathways related to the development of tobacco-related diseases. Methods This paper is built upon a review of the existing scientific literature on selected biopsychosocial factors (diet/nutrition, obesity, alcoholic intake, psychosocial stress, occupational/environmental exposures and exposure to other diseases and illnesses) and tobacco use in examining the biological contributions to differences in tobacco-related health outcomes among RCSGs. Findings Recent work has focused on RCSG genetic variations as a possible explanation for differences in tobacco-related health disparities. It is argued in this paper that, given the genetic heterogeneity `within' RCSGs, it is unlikely that across RCSG genetic variations are likely to be the major source of differences impacting biological pathways in tobacco-related health outcomes. The evidence shows that results, even at the level of within-population genetic variations, have been limited and often inconsistent. A conceptual framework is proposed to account for biological pathways related to the development of tobacco-related diseases. Conclusions Determinants of tobacco-related health disparities are not understood clearly. The contribution of biological factors may be important. Current efforts to determine biological differences in tobacco use and related diseases among RCSGs have focused primarily on genetic variations. However, this approach has limitations. An alternative biopsychosocial framework that examines the potential biological mechanisms through which life experiences and behavior might affect tobacco use and health outcomes in these population groups is needed, including those of life-style (e.g. diet/nutrition, obesity, physical exercise, alcohol consumption), psychosocial (e.g. stress and coping), occupational/environmental exposures and the presence of other diseases/illnesses. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Fernander, Anita F AU - Shavers, Vickie L AU - Hammons, George J AD - University of Kentucky ; National Cancer Institute, USA ; Philander Smith College Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 43 EP - 57 VL - 102 IS - Supp.2 SN - 0965-2140, 0965-2140 KW - Sociology KW - Groups KW - Genetics KW - Psychology KW - Race KW - Tobacco KW - Diseases KW - Health inequality KW - Illness KW - Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36736853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=A+biopsychosocial+approach+to+examining+tobacco-related+health+disparities+among+racially+classified+social+groups&rft.au=Fernander%2C+Anita+F%3BShavers%2C+Vickie+L%3BHammons%2C+George+J&rft.aulast=Fernander&rft.aufirst=Anita&rft.date=2007-10-01&rft.volume=102&rft.issue=Supp.2&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01954.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10404; 12766 3055 798 10286; 5783 5772 6489; 10555 6091; 5676; 3617 6220; 1615 8573 11325; 5460 1615 8573 11325; 6220 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01954.x ER - TY - JOUR T1 - Addressing tobacco-related health disparities AN - 36734635; 3460426 AB - Aims The aim of this review is to outline a transdisciplinary research framework for identifying, explaining and intervening to address tobacco-related health disparities (TRHD). We will show the importance of an approach that integrates the human life-cycle (developmental) and tobacco addiction cycle (behavioral) for interventions that address group-specific vulnerabilities. Methods The existing empirical knowledge base on tobacco-related health disparities is mapped onto a conceptual framework built around life-cycle and addiction cycle trajectories for disparate population groups. Findings Current knowledge about developmental trajectories of tobacco use is based on general population studies with minimal information on group differences. At the national level, early onset of tobacco use is associated with a high level of tobacco dependence, low number of quit attempts, long-term smoking history and tobacco-related health harm. These relationships cannot be assumed for all population groups: African Americans and Asian Americans typically have a later age of tobacco use onset compared to European Americans, yet health consequences of smoking are higher among African Americans but not Asian Americans. Even less is known about group differences in the temporal progression from smoking onset to daily smoking. Determining the time-frame from initial to regular smoking seems crucial for targeted secondary prevention, before the establishment of addictive tobacco use patterns. Group-specific data characterizing the duration from daily tobacco use to a quit attempt or request for cessation treatment are also scant. Conclusions A comprehensive, integrated, transdisciplinary framework is needed to guide efforts to understand tobacco-related health disparities and to increase the effectiveness of evidence-based interventions delivered in culturally appropriate and economically practicable ways, while optimizing the balance between demand for and access to services. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Moolchan, Eric T AU - Fagan, Pebbles AU - Fernander, Anita F AU - Velicer, Wayne F AU - Hayward, Mark D AU - King, Gary AU - Clayton, Richard R AD - National Institute on Drug Abuse, Baltimore ; National Cancer Institute, USA ; University of Kentucky ; University of Rhode Island ; University of Texas, Austin ; Pennsylvania State University Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 30 EP - 42 VL - 102 IS - Supp.2 SN - 0965-2140, 0965-2140 KW - Sociology KW - Life cycles KW - Ethnicity KW - Tobacco KW - Race KW - Medical treatment KW - Addiction KW - African-Americans KW - Empirical research KW - Health inequality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36734635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addressing+tobacco-related+health+disparities&rft.au=Moolchan%2C+Eric+T%3BFagan%2C+Pebbles%3BFernander%2C+Anita+F%3BVelicer%2C+Wayne+F%3BHayward%2C+Mark+D%3BKing%2C+Gary%3BClayton%2C+Richard+R&rft.aulast=Moolchan&rft.aufirst=Eric&rft.date=2007-10-01&rft.volume=102&rft.issue=Supp.2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01953.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4200 10902; 635 1656 10555 6091 961 636 4424; 10555 6091; 561 6220; 4435; 7396 3245 971; 12766 3055 798 10286; 7890 5792 10484; 5783 5772 6489 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01953.x ER - TY - JOUR T1 - The alcohol dependence syndrome, 30 years later: a commentary AN - 36724557; 3455273 AB - Aims Major classification systems for alcohol use disorders (DSM-IV and ICD-10) contain elements of the 1976 Edwards and Gross formulation of the Alcohol Dependence Syndrome (ADS). However, issues remain about the criteria that identify Alcohol Dependence (AD) as distinct from Alcohol Abuse (AA) in DSM-IV and Harmful Use in ICD-10. These issues, in part, have their roots in changing historical perceptions of alcohol use and its problems. We discuss current diagnostic criteria for AA and AD, collectively called Alcohol Use Disorders (AUDs), in the context of their historical evolution; research progress in understanding alcohol problems, including alcohol dependence; new findings on the severity of AUDs as classified by DSM-IV; and the role of alcohol consumption patterns in future classifications of AUDs. Methods This paper is based largely on the 2006 H. David Archibald Lecture. Parts of the original lecture have been modified to reflect more recent findings from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). Results The original Edwards and Gross ADS construct is supported by advances in biological and behavioral science over the past 30 years. New findings indicate that DSM-IV AA and AD are not diagnostically distinct entities, but represent a continuum of severity of AUDs. The ADS criteria may best represent one quantifiable dimension of alcohol use problems and this scale can be related to that of the frequency of harmful patterns of drinking. Conclusion The Edwards and Gross ADS criteria can be used as the basis for beginning the development of scalable multi-dimensional criteria for diagnosing AUDs in new initiatives to revise DSM-IV and ICD-10. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Li, Ting-kai AU - Hewitt, Brenda G AU - Grant, Bridget F AD - National Institutes of Health, Bethesda Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1522 EP - 1530 VL - 102 IS - 10 SN - 0965-2140, 0965-2140 KW - Sociology KW - Epidemiology KW - Perception KW - Alcoholism KW - Consumption KW - Diseases KW - Addiction KW - Behavioural sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36724557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+alcohol+dependence+syndrome%2C+30+years+later%3A+a+commentary&rft.au=Li%2C+Ting-kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-kai&rft.date=2007-10-01&rft.volume=102&rft.issue=10&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01911.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2805 3872 554 971; 4357 7894; 1542 11325; 9382; 913 561 6220; 561 6220; 3617 6220 DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01911.x ER - TY - JOUR T1 - Prolonged Reduction of CCR5 Expression in Multiple Hematopoietic Cell Lineages by RNA Interference Through CD34+ Cell Transplant in Non-Human Primates AN - 21141743; 7660780 AB - RNAi has tremendous potential for therapeutic application in suppressing gene expression. As endogenous RNAi play a role in normal cellular function, delivery and expression of siRNAs must be balanced with safety. Here we report successful stable expression of siRNAs directed to the HIV-1 co-receptor, chemokine receptor 5 (CCR5), when introduced through non-human primate CD34+ hematopoietic stem/progenitor cells. CD34+ cells transduced with a lentiviral vector expressing EGFP were observed to contribute to CCR5-expressing lymphocytes in multiple tissues, including those involved in gastrointestinal immunity, which are particularly susceptible to HIV/SIV infection. In this study two rhesus macaques were transplanted with autologous peripheral blood (PB) mobilized CD34+ cells transduced with a CCR5-shRNA lentiviral vector co-expressing EGFP. To date (over 24 months), 5-10% of all circulating leukocytes expressed EGFP. In addition, cell surface expression of CCR5 was reduced 3-10-fold in the EGFP+ population relative to the EGFP- population. The 22-nucleotide band corresponding to the antisense strand of CCR5 siRNA could be detected by northern blot, and real-time RT-PCR indicated expression of approximately 3 x 10 super(4) siRNA molecules per EGFP+ cell in PHA/IL-2-stimulated PB T lymphocytes. Flow cytometric and cytokine proliferation profiles were nearly identical for EGFP+ and EGFP- subpopulations, suggesting that there was no selective toxicity associated with the expression of the siRNA. Lymphocytes sorted by EGFP+ and EGFP- were used to evaluate the susceptibility of the PB lymphocytes to SIVmac239 infection at an MOI of 0.04. Both subpopulations proliferated with comparable kinetics; however, the EGFP+ population of cells produced 2-3-fold lower levels of p27 SIV gag capsid antigen than did the EGFP- population over the 9-day culture period. These studies provide the first successful demonstration that siRNAs can be utilized together with hematopoietic stem cell transplantation in order to stably modulate gene expression in non-human primates. JF - Human Gene Therapy AU - Donahue, R AU - An, D-S AU - Kamata, M AU - Mattapallil, J AU - Poon, B AU - Metzger, M AU - Mao, S-H AU - Bonifacino, A AU - Krouse, A AU - Darlix, J-L AU - Baltimore, D AU - Qin, FX-F AU - Chen, ISY AD - Hematology Branch, National Heart, Lung, and Blood Institute, Rockville, MD, USA, donahuer@nhlbi.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 949 PB - Mary Ann Liebert, Inc. Publishers, 140 Huguenot St 3rd Fl New Rochelle NY 10801 USA VL - 18 IS - 10 SN - 1043-0342, 1043-0342 KW - HIV-1 KW - Rhesus macaque KW - Rhesus monkey KW - SIV KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Therapeutic applications KW - Chemokine receptors KW - Cell culture KW - CCR5 protein KW - Infection KW - Flow cytometry KW - Gene expression KW - Antisense KW - Stem cells KW - Human immunodeficiency virus 1 KW - Lymphocytes T KW - Polymerase chain reaction KW - Macaca mulatta KW - Autografts KW - Capsids KW - Cell lineage KW - Gene therapy KW - stem cell transplantation KW - Leukocytes KW - CD34 antigen KW - Peripheral blood KW - Immunity KW - Toxicity KW - Primates KW - Gag protein KW - siRNA KW - Kinetics KW - RNA-mediated interference KW - Hemopoiesis KW - Simian immunodeficiency virus KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21141743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Human+Gene+Therapy&rft.atitle=Prolonged+Reduction+of+CCR5+Expression+in+Multiple+Hematopoietic+Cell+Lineages+by+RNA+Interference+Through+CD34%2B+Cell+Transplant+in+Non-Human+Primates&rft.au=Donahue%2C+R%3BAn%2C+D-S%3BKamata%2C+M%3BMattapallil%2C+J%3BPoon%2C+B%3BMetzger%2C+M%3BMao%2C+S-H%3BBonifacino%2C+A%3BKrouse%2C+A%3BDarlix%2C+J-L%3BBaltimore%2C+D%3BQin%2C+FX-F%3BChen%2C+ISY&rft.aulast=Donahue&rft.aufirst=R&rft.date=2007-10-01&rft.volume=18&rft.issue=10&rft.spage=949&rft.isbn=&rft.btitle=&rft.title=Human+Gene+Therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Chemokine receptors; Therapeutic applications; CCR5 protein; Cell culture; Infection; Gene expression; Flow cytometry; Stem cells; Antisense; Lymphocytes T; Polymerase chain reaction; Cell lineage; Capsids; Autografts; Gene therapy; stem cell transplantation; Leukocytes; Peripheral blood; CD34 antigen; Toxicity; Immunity; Gag protein; siRNA; Kinetics; Hemopoiesis; RNA-mediated interference; Human immunodeficiency virus 1; Macaca mulatta; Primates; Simian immunodeficiency virus ER - TY - JOUR T1 - Garlic, Vitamin, and Antibiotic Treatment for Helicobacter pylori: A Randomized Factorial Controlled Trial AN - 21121695; 7900752 JF - Helicobacter AU - Gail, Mitchell H AU - Pfeiffer, Ruth M AU - Brown, Linda M AU - Zhang, Lian AU - Ma, Jun-ling AU - Pan, Kai-feng AU - Liu, Wei-dong AU - You, Wei-cheng AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA,, gailm@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 575 EP - 578 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 12 IS - 5 SN - 1083-4389, 1083-4389 KW - Microbiology Abstracts B: Bacteriology KW - Helicobacter pylori KW - Allium sativum KW - Vitamins KW - Antibiotics KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21121695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Helicobacter&rft.atitle=Garlic%2C+Vitamin%2C+and+Antibiotic+Treatment+for+Helicobacter+pylori%3A+A+Randomized+Factorial+Controlled+Trial&rft.au=Gail%2C+Mitchell+H%3BPfeiffer%2C+Ruth+M%3BBrown%2C+Linda+M%3BZhang%2C+Lian%3BMa%2C+Jun-ling%3BPan%2C+Kai-feng%3BLiu%2C+Wei-dong%3BYou%2C+Wei-cheng&rft.aulast=Gail&rft.aufirst=Mitchell&rft.date=2007-10-01&rft.volume=12&rft.issue=5&rft.spage=575&rft.isbn=&rft.btitle=&rft.title=Helicobacter&rft.issn=10834389&rft_id=info:doi/10.1111%2Fj.1523-5378.2007.00528.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vitamins; Antibiotics; Helicobacter pylori; Allium sativum DO - http://dx.doi.org/10.1111/j.1523-5378.2007.00528.x ER - TY - JOUR T1 - Clinical significance of the presence of amniotic fluid sludge in asymptomatic patients at high risk for spontaneous preterm delivery AN - 21065728; 8635431 AB - Objectives To determine the clinical significance of the presence of amniotic fluid (AF) sludge among asymptomatic patients at high risk for spontaneous preterm delivery. Methods This retrospective case-control study included 281 patients with (n = 66) or without (n = 215) AF sludge, who underwent transvaginal ultrasound examination between 13 and 29 completed weeks of gestation. Patients with threatened preterm labor, multiple gestation, fetal anomalies, placenta previa or uterine contractions were excluded. Results The prevalence of AF sludge in the study population was 23.5% (66/281). The rates of spontaneous preterm delivery at < 28 weeks, < 32 weeks, < 35 weeks and < 37 weeks of gestation were 14.7% (29/197), 21.3% (46/216), 28.7% (62/216) and 42.1% (91/216), respectively. Patients with sludge had: (1) a higher rate of spontaneous preterm delivery at < 28 weeks (46.5% (20/43) vs. 5.8% (9/154); P < 0.001), < 32 weeks (55.6% (25/45) vs. 12.3% (21/171); P < 0.001) and < 35 weeks (62.2% (28/45) vs. 19.9% (34/171); P < 0.001); (2) a higher frequency of clinical chorioamnionitis (15.2% (10/66) vs. 5.1% (11/215); P = 0.007), histologic chorioamnionitis (61.5% (40/65) vs. 28% (54/193); P < 0.001) and funisitis (32.3% (21/65) vs. 19.2% (37/193); P = 0.03); (3) a higher frequency of preterm prelabor rupture of membranes (PROM) (39.4% (26/66) vs. 13.5% (29/215); P < 0.001), lower gestational age at preterm PROM (median 24.7 (interquartile range (IQR), 22.3-28.1) weeks vs. 32.3 (IQR, 27.7-34.8) weeks; P < 0.001); and (4) shorter median ultrasound-to-delivery interval (sludge positive 127 days (95% CI, 120-134 days) vs. sludge negative 161 days (95% CI, 153-169 days); P < 0.001) and ultrasound-to-preterm PROM interval (sludge positive 23 days (95% CI, 7-39 days) vs. sludge negative 57 days (95% CI, 38-77 days); P = 0.003) than those without sludge. AF sludge was an independent explanatory variable for the occurrence of spontaneous preterm delivery at < 28 weeks, < 32 weeks and < 35 weeks, preterm PROM, microbial invasion of the amniotic cavity (MIAC) and histologic chorioamnionitis. Moreover, the combination of a cervical length < 25 mm and sludge conferred an odds ratio of 14.8 and 9.9 for spontaneous preterm delivery at < 28 weeks and < 32 weeks, respectively. Conclusions AF sludge is an independent risk factor for spontaneous preterm delivery, preterm PROM, MIAC and histologic chorioamnionitis in asymptomatic patients at high risk for spontaneous preterm delivery. Furthermore, the combination of sludge and a short cervix confers a higher risk for spontaneous preterm delivery at < 28 weeks and < 32 weeks than a short cervix alone. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Espinoza, J AU - Romero, R AU - Goncalves, L F AU - Nien, J K AU - Soto, E AU - Khalek, N AU - Camacho, N AU - Hendler, I AU - Mittal, P AU - Friel, L A AU - Gotsch, F AU - Erez, O AU - Than, N G AU - Mazaki-Tovi, S AU - Schoen, M L AU - Hassan, S S AD - Perinatology Research Branch, National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Department of Health and Human Services, Bethesda, MD and Detroit, MI, USA, nichdprbchiefstaff@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 706 EP - 714 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 5 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Cavities KW - Uterus KW - Gestational age KW - Gynecology KW - Sludges KW - Rupture KW - Population studies KW - Fetuses KW - Placenta KW - Risk factors KW - Chorioamnionitis KW - Cervix KW - Obstetrics KW - Ultrasound KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21065728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Clinical+significance+of+the+presence+of+amniotic+fluid+sludge+in+asymptomatic+patients+at+high+risk+for+spontaneous+preterm+delivery&rft.au=Kusanovic%2C+J+P%3BEspinoza%2C+J%3BRomero%2C+R%3BGoncalves%2C+L+F%3BNien%2C+J+K%3BSoto%2C+E%3BKhalek%2C+N%3BCamacho%2C+N%3BHendler%2C+I%3BMittal%2C+P%3BFriel%2C+L+A%3BGotsch%2C+F%3BErez%2C+O%3BThan%2C+N+G%3BMazaki-Tovi%2C+S%3BSchoen%2C+M+L%3BHassan%2C+S+S&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2007-10-01&rft.volume=30&rft.issue=5&rft.spage=706&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.4081 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sludges; Risk factors; Chorioamnionitis; Ultrasound; Cervix; Amniotic fluid; Cavities; Gestational age; Placenta; Gynecology; Fetuses; Obstetrics; Population studies; Rupture; Uterus DO - http://dx.doi.org/10.1002/uog.4081 ER - TY - JOUR T1 - What is amniotic fluid sludge? AN - 21064478; 8635447 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Romero, R AU - Kusanovic, J P AU - Espinoza, J AU - Gotsch, F AU - Nhan-Chang, C L AU - Erez, O AU - Kim, C J AU - Khalek, N AU - Mittal, P AU - Goncalves, L F AU - Schaudinn, C AU - Hassan, S S AU - Costerton, J W AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland and Detroit, Michigan, USA, prbchiefstaff@med.wayne.edu Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 793 EP - 798 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 5 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Gynecology KW - Sludges KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21064478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=What+is+amniotic+fluid+sludge%3F&rft.au=Romero%2C+R%3BKusanovic%2C+J+P%3BEspinoza%2C+J%3BGotsch%2C+F%3BNhan-Chang%2C+C+L%3BErez%2C+O%3BKim%2C+C+J%3BKhalek%2C+N%3BMittal%2C+P%3BGoncalves%2C+L+F%3BSchaudinn%2C+C%3BHassan%2C+S+S%3BCosterton%2C+J+W&rft.aulast=Romero&rft.aufirst=R&rft.date=2007-10-01&rft.volume=30&rft.issue=5&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.5173 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Amniotic fluid; Gynecology; Sludges; Ultrasound DO - http://dx.doi.org/10.1002/uog.5173 ER - TY - JOUR T1 - Prevention of spontaneous preterm birth: the role of sonographic cervical length in identifying patients who may benefit from progesterone treatment AN - 21063815; 8635428 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Romero, Roberto AD - Perinatology Research Branch, Intramural Division, NICHD/NIH/DHHS, Bethesda, Maryland, USA and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 675 EP - 686 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 30 IS - 5 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Birth KW - Gynecology KW - Progesterone KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21063815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=Prevention+of+spontaneous+preterm+birth%3A+the+role+of+sonographic+cervical+length+in+identifying+patients+who+may+benefit+from+progesterone+treatment&rft.au=Romero%2C+Roberto&rft.aulast=Romero&rft.aufirst=Roberto&rft.date=2007-10-01&rft.volume=30&rft.issue=5&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.5174 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Progesterone; Birth; Gynecology; Ultrasound DO - http://dx.doi.org/10.1002/uog.5174 ER - TY - JOUR T1 - Cocaine and Metabolites Urinary Excretion after Controlled Smoked Administration AN - 20855296; 8343839 AB - Understanding cocaine and metabolites urinary excretion following smoking is important for interpretation of urine test results in judicial, workplace and treatment settings. In National Institute on Drug Abuse approved studies on a secure research unit, six subjects smoked placebo, 10, 20, and 40 mg cocaine with a precise dose delivery device and six different subjects smoked 42 mg cocaine in a glass pipe. Urine specimens (n = 700) were collected for up to seven days and analyzed for cocaine (COC), benzoylecgonine (BE), ecgonine methylester (EME), m-hydroxybenzoylecgonine (mOHBE), p-hydroxybenzoylecgonine (pOHBE), norbenzoylecgonine (NBE), and ecgonine (EC) by gas chromatography-mass spectrometry.?Mean Cmax for ail analytes linearly increased with increasing dose. Tmax was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe. JF - Journal of Analytical Toxicology AU - Huestis, MA AU - Darwin, W D AU - Shimomura, E AU - Lalani, SA AU - Trinidad, D V AU - Jenkins, A J AU - Cone, E J AU - Jacobs, A J AU - Smith, M L AU - Paul, B D AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 462 EP - 468 VL - 31 IS - 8 SN - 0146-4760, 0146-4760 KW - Toxicology Abstracts KW - Smoking KW - Urine KW - Metabolites KW - Excretion KW - Cocaine KW - Drug abuse KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Cocaine+and+Metabolites+Urinary+Excretion+after+Controlled+Smoked+Administration&rft.au=Huestis%2C+MA%3BDarwin%2C+W+D%3BShimomura%2C+E%3BLalani%2C+SA%3BTrinidad%2C+D+V%3BJenkins%2C+A+J%3BCone%2C+E+J%3BJacobs%2C+A+J%3BSmith%2C+M+L%3BPaul%2C+B+D&rft.aulast=Huestis&rft.aufirst=MA&rft.date=2007-10-01&rft.volume=31&rft.issue=8&rft.spage=462&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smoking; Urine; Excretion; Metabolites; Drug abuse; Cocaine ER - TY - JOUR T1 - Drug-drug interactions affected by the transporter protein, P-glycoprotein (ABCB1, MDR1) AN - 20845779; 8242992 AB - The simultaneous use of several drugs (polypharmacy) for the treatment of cancer, HIV, and other diseases and for multiple ailments of the elderly is a common practice in modern medicine. Co-administration of drugs may result in unwanted side effects. One reason for these side effects can be the altered function of transport proteins, especially of P-glycoprotein (Pgp), due to its simultaneous interaction with several drugs. We describe here some of the observed, unexpected side effects of polypharmacy in the clinic. We also describe intentional modulation of the function of Pgp that is introduced when facilitation of absorption of a drug through the intestines is needed and in cancer chemotherapy. In addition, we mention some methods of testing and ways by which doctors and patients can be alerted to potential side effects. JF - Drug Discovery Today AU - Aszalos, A AD - 37 Convent Drive, Room 2108, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States, aszalosa@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 838 EP - 843 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 12 IS - 19-20 SN - 1359-6446, 1359-6446 KW - Toxicology Abstracts KW - Protein transport KW - Drug interaction KW - P-Glycoprotein KW - Human immunodeficiency virus KW - Chemotherapy KW - Intestine KW - Geriatrics KW - Side effects KW - Cancer KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20845779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Drug-drug+interactions+affected+by+the+transporter+protein%2C+P-glycoprotein+%28ABCB1%2C+MDR1%29&rft.au=Aszalos%2C+A&rft.aulast=Aszalos&rft.aufirst=A&rft.date=2007-10-01&rft.volume=12&rft.issue=19-20&rft.spage=838&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2007.07.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drug interaction; Protein transport; P-Glycoprotein; Chemotherapy; Geriatrics; Intestine; Cancer; Side effects; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.drudis.2007.07.021 ER - TY - JOUR T1 - Reliability of MR Perfusion-Weighted and Diffusion-Weighted Imaging Mismatch Measurement Methods AN - 20837437; 7608326 AB - BACKGROUND: AND PURPOSE: We investigated 2 methods of measuring MR imaging perfusion-diffusion mismatch to determine whether reliability is improved by direct measurement on a single, blended map. MATERIALS AND METHODS: Image software was used for measurement of lesion volumes from diffusion-weighted images (DWI) and mean transit time (MTT) calculated from perfusion-weighted (PWI) images on 64 patients with acute stroke. For the first method, the DWI and MTT lesions were measured separately. For the second method, the mismatch volume was measured directly on the blended images created from the registered DWI and MTT images. RESULTS: Test-retest agreement was 100% and 97% for the separate and blended methods using mismatch cutoffs of 20% or more versus less than 20%. There were no significant differences in the mismatch statistics between the methods. CONCLUSIONS: Mismatch volumes by a single reader can provide highly reliable and consistent results even when separately measuring DWI and MTT lesions. Propagation of measurement error was not demonstrated, and the methods were statistically comparable. JF - American Journal of Neuroradiology AU - Luby, M AU - Warach, S AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1674 EP - 1678 PB - American Society of Neuroradiology, 2210 Midwest Rd. Ste. 207 Oak Brood IL 60521 USA, [mailto:ajnr@interaccess.com] VL - 28 IS - 9 SN - 0195-6108, 0195-6108 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Statistics KW - Magnetic resonance imaging KW - Stroke KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20837437?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Neuroradiology&rft.atitle=Reliability+of+MR+Perfusion-Weighted+and+Diffusion-Weighted+Imaging+Mismatch+Measurement+Methods&rft.au=Luby%2C+M%3BWarach%2C+S&rft.aulast=Luby&rft.aufirst=M&rft.date=2007-10-01&rft.volume=28&rft.issue=9&rft.spage=1674&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Neuroradiology&rft.issn=01956108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Statistics; Stroke; Magnetic resonance imaging ER - TY - JOUR T1 - Adolescent-Mother Agreement about Adolescent Problem Behaviors: Direction and Predictors of Disagreement AN - 20763511; 7968778 AB - Correlations between adolescent and parent reports of adolescent problems are low in magnitude. In community samples adolescents tend to report more problems than parents and in clinical samples adolescents tend to report fewer problems than parents. Indices of agreement may be biased if some adolescents in a given sample report more problems and others report fewer problems than parents. In the current study, order and mean agreement between adolescent and maternal reports of adolescent internalizing and externalizing problems, taking into account the direction of disagreement, was examined in a community sample of 133 young adolescents and their mothers. Two-thirds to three-quarters of adolescents reported more problems than mothers. Accounting for the direction of discrepancies resulted in improved agreement between adolescents and mothers and differing patterns of predictors of discrepancies. Additionally, the results demonstrate the need to control for relations between adolescent-reported problems and discrepancies when exploring predictors of discrepancies. JF - Journal of Youth and Adolescence AU - Barker, Erin T AU - Bornstein, Marc H AU - Putnick, Diane L AU - Hendricks, Charlene AU - Suwalsky, Joan TD AD - National Institute of Child Health and Human Development, National Institutes of Health, 6705 Rockledge Drive, Suite 8030, Bethesda, MD, 20892-7971, USA, barkerer@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 950 EP - 962 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 36 IS - 7 SN - 0047-2891, 0047-2891 KW - Physical Education Index KW - Adolescence KW - Youth KW - PE 120:Sport: Psychology, Sociology & History UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20763511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Youth+and+Adolescence&rft.atitle=Adolescent-Mother+Agreement+about+Adolescent+Problem+Behaviors%3A+Direction+and+Predictors+of+Disagreement&rft.au=Barker%2C+Erin+T%3BBornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BHendricks%2C+Charlene%3BSuwalsky%2C+Joan+TD&rft.aulast=Barker&rft.aufirst=Erin&rft.date=2007-10-01&rft.volume=36&rft.issue=7&rft.spage=950&rft.isbn=&rft.btitle=&rft.title=Journal+of+Youth+and+Adolescence&rft.issn=00472891&rft_id=info:doi/10.1007%2Fs10964-006-9164-0 LA - English DB - Physical Education Index N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adolescence; Youth DO - http://dx.doi.org/10.1007/s10964-006-9164-0 ER - TY - JOUR T1 - Wastewater Toxicity of Tannin- Versus Chromium-Based Leather Tanneries in Marrakesh, Morocco AN - 20728592; 7623463 AB - The toxicity of leather tanning wastewater from a traditional tannery (TT), which is based on vegetable tannin (VT), was compared with wastewater from a tannery combining the use of chromium-based tanning (CT) with VT-based tanning operations. Wastewater samples from a TT and a CT plant as well as from five sewer sampling points were collected in Marrakesh, Morocco, and the concentrations of VT and some selected inorganics were measured. A set of bioassays were used to test wastewater toxicity in sea urchin (Paracentrotus lividus) embryos and sperm, in Daphnia magna, and in marine microalgae (Dunaliella tertiolecta). Toxicity end points included: (1) developmental defects, embryonic mortality, sperm fertilization success, and offspring damage in sea urchins; (2) D. magna immobilization; and (3) algal growth rate inhibition. Toxicity tests on TT and CT effluents (TTE and CTE) were run at dilutions ranging from 0.1% to 2% (sea urchins and algae) or up to 12% in D. magna. Parallel bioassays were run on VT extract (VTE) at nominal tannin concentrations ranging from 0.1 to 10 mg l super(-1). The results showed higher toxicity of CTE compared with TTE. CTE toxicity in sea urchins and algae showed concentration-related trends, whereas TTE exerted hormetic effects at levels of 0.1% to 0.2% and toxic effects at levels .1%. The same trends were observed for VTE, suggesting a prevailing role of tannin in TTE-associated effects. The moderate wastewater toxicity of VT-based tanneries might prompt interest in the VT tanning process. JF - Archives of Environmental Contamination and Toxicology AU - Nicola, E AU - Meric, S AU - Della Rocca, C AU - Gallo, M AU - Iaccarino, M AU - Manini, P AU - Petruzzelli, D AU - Belgiorno, V AU - Cheggour, M AU - Di Gennaro, A AU - Moukrim, A AU - Tuenay, O AU - Pagano, G AD - Italian National Cancer Institute, I-80131, Naples, Italy, gbpagano@tin.it Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 321 EP - 328 PB - Springer-Verlag, 175 Fifth Ave. New York NY 10010 USA, [mailto:orders@springer-ny.com], [URL:http://www.springer-ny.com/] VL - 53 IS - 3 SN - 0090-4341, 0090-4341 KW - Pollution Abstracts; Toxicology Abstracts; ASFA Aquaculture Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Water Resources Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Aqualine Abstracts KW - toxicity testing KW - Echinoderms KW - Vegetables KW - Sperm KW - Toxicity tests KW - Bioassay KW - Fertilization KW - Embryos KW - Algae KW - Embryonic development KW - Tannery Wastes KW - Tannins KW - Morocco, Marrakesh KW - Effluents KW - fertilization KW - Bioassays KW - Water Pollution Effects KW - Progeny KW - Echinoidea KW - Wastewater KW - Leather KW - ASE, Morocco KW - Daphnia magna KW - Dunaliella tertiolecta KW - Sewers KW - Tanning KW - tanneries KW - Sampling KW - Tannic acid KW - Aquaculture techniques KW - offspring KW - Paracentrotus lividus KW - Growth rate KW - Marine KW - Mortality KW - Industrial Wastewater KW - tannic acid KW - Toxicity KW - Waste water KW - Immobilization KW - Mortality causes KW - X 24370:Natural Toxins KW - P 1000:MARINE POLLUTION KW - Q5 08504:Effects on organisms KW - SW 3030:Effects of pollution KW - AQ 00008:Effects of Pollution KW - Q3 08588:Effects of Aquaculture on the Environment KW - K 03320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20728592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+Contamination+and+Toxicology&rft.atitle=Wastewater+Toxicity+of+Tannin-+Versus+Chromium-Based+Leather+Tanneries+in+Marrakesh%2C+Morocco&rft.au=Nicola%2C+E%3BMeric%2C+S%3BDella+Rocca%2C+C%3BGallo%2C+M%3BIaccarino%2C+M%3BManini%2C+P%3BPetruzzelli%2C+D%3BBelgiorno%2C+V%3BCheggour%2C+M%3BDi+Gennaro%2C+A%3BMoukrim%2C+A%3BTuenay%2C+O%3BPagano%2C+G&rft.aulast=Nicola&rft.aufirst=E&rft.date=2007-10-01&rft.volume=53&rft.issue=3&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+Contamination+and+Toxicology&rft.issn=00904341&rft_id=info:doi/10.1007%2Fs00244-006-0181-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2016-02-18 N1 - SubjectsTermNotLitGenreText - Bioassays; Embryonic development; Toxicity; Effluents; Toxicity tests; Mortality causes; Aquaculture techniques; Algae; Growth rate; Mortality; Vegetables; Leather; Sperm; Fertilization; Sewers; Tanning; Progeny; tanneries; Embryos; Tannic acid; Sampling; Waste water; Immobilization; toxicity testing; fertilization; tannic acid; Wastewater; offspring; Echinoderms; Industrial Wastewater; Water Pollution Effects; Tannery Wastes; Tannins; Bioassay; Paracentrotus lividus; Dunaliella tertiolecta; Echinoidea; Daphnia magna; ASE, Morocco; Morocco, Marrakesh; Marine DO - http://dx.doi.org/10.1007/s00244-006-0181-5 ER - TY - JOUR T1 - Chronic Carbamazepine Administration Reduces N-Methyl-D-Aspartate Receptor-Initiated Signaling via Arachidonic Acid in Rat Brain AN - 20680428; 9450283 AB - Lithium and carbamazepine (CBZ) are used to treat mania in bipolar disorder. When given chronically to rats, both agents reduce arachidonic acid (AA) turnover in brain phospholipids and downstream AA metabolism. Lithium in rats also attenuates brain N-methyl-D-aspartic acid receptor (NMDAR) signaling via AA. We hypothesized that, like chronic lithium, chronic CBZ administration to rats would reduce NMDAR-mediated signaling via AA. Methods We used our fatty acid method with quantitative autoradiography to image the regional brain incorporation coefficient k* of AA, a marker of AA signaling, in unanesthetized rats that had been given 25 mg/kg/day IP CBZ or vehicle for 30 days, then injected with NMDA (25 mg/kg IP) or saline. We also measured brain concentrations of two AA metabolites, prostaglandin E2 (PGE2) and thromboxane B2 (TXB2). Results In chronic vehicle-treated rats, NMDA compared with saline increased k* significantly in 69 of 82 brain regions examined, but did not change k* significantly in any region in CBZ-treated rats. In vehicle- but not CBZ-treated rats, NMDA also increased brain concentrations of PGE2 and TXB2. Conclusions Chronic CBZ administration to rats blocks increments in the AA signal k*, and in PGE2 and TXB2 concentrations that are produced by NMDA in vehicle-treated rats. The clinical action of antimanic drugs might involve inhibition of brain NMDAR-mediated signaling involving AA and its metabolites. JF - Biological Psychiatry AU - Basselin, Mireille AU - Villacreses, Nelly E AU - Chen, Mei AU - Bell, Jane M AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland., mirvasln@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 934 EP - 943 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 62 IS - 8 SN - 0006-3223, 0006-3223 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Thromboxanes KW - Neuroimaging KW - N-Methyl-D-aspartic acid receptors KW - Affective disorders KW - Brain KW - Arachidonic acid KW - Metabolites KW - Prostaglandin E2 KW - Autoradiography KW - Glutamic acid receptors KW - Carbamazepine KW - Bipolar disorder KW - Fatty acids KW - Drugs KW - Lithium KW - Signal transduction KW - Phospholipids KW - X 24310:Pharmaceuticals KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20680428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Psychiatry&rft.atitle=Chronic+Carbamazepine+Administration+Reduces+N-Methyl-D-Aspartate+Receptor-Initiated+Signaling+via+Arachidonic+Acid+in+Rat+Brain&rft.au=Basselin%2C+Mireille%3BVillacreses%2C+Nelly+E%3BChen%2C+Mei%3BBell%2C+Jane+M%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2007-10-01&rft.volume=62&rft.issue=8&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Biological+Psychiatry&rft.issn=00063223&rft_id=info:doi/10.1016%2Fj.biopsych.2007.04.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Thromboxanes; N-Methyl-D-aspartic acid receptors; Neuroimaging; Affective disorders; Brain; Arachidonic acid; Metabolites; Prostaglandin E2; Autoradiography; Glutamic acid receptors; Carbamazepine; Bipolar disorder; Fatty acids; Drugs; Lithium; Phospholipids; Signal transduction DO - http://dx.doi.org/10.1016/j.biopsych.2007.04.021 ER - TY - JOUR T1 - Distinct contributions of frontal areas to emotion and social behaviour in the rat AN - 20640215; 7981407 AB - Although the lesions of patients with impaired social behaviour encompass both orbitofrontal and anterior cingulate cortex (OFC and ACC), attempts to model such impairments in animals have focused on the OFC. However, recent neuroimaging attempts to identify the neural correlates of social interaction have emphasized the relative importance of ACC. Here we report the effect of circumscribed excitotoxic lesions of either OFC or ACC on ethological, unconditioned tests of emotion and social behaviour in the Lister hooded rat. OFC lesions altered emotional responsiveness to stimuli in non-social, fear-inducing situations (hyponeophagia test), and produced a small but statistically significant increase in aggression to other rats, but did not compromise other aspects of social interaction and appraisal. ACC lesions did, however, affect the utilization of social information. Specifically, ACC lesions diminished interest in other individuals and caused a relative reduction in memory for social stimuli. Whereas normal animals habituated to repeated presentations of the same individual, the poor performance of ACC animals entailed continued higher levels of responsiveness to repeated presentations of the same individual. The ACC impairment cannot simply be attributed to a general reduction in arousal, or a general impairment in recognition memory. Neither lesion affected anxiety per se (successive alleys test). Further analyses were conducted to investigate whether the changes in aggressive and social behaviour were related to different aspects of decision-making. Although the relationship between changes in social interaction and decision-making after ACC lesions is unclear, OFC impairments in emotionality were correlated with increased impulsive choice. JF - European Journal of Neuroscience AU - Rudebeck, Peter H AU - Walton, Mark E AU - Millette, Benjamin HP AU - Shirley, Elizabeth AU - Rushworth, Matthew FS AU - Bannerman, David M AD - Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK, rudebeckp@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2315 EP - 2326 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 26 IS - 8 SN - 0953-816X, 0953-816X KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - anxiety KW - behaviour KW - emotion KW - rat KW - Emotions KW - Neuroimaging KW - Anxiety KW - Arousal KW - Statistical analysis KW - Cortex (frontal) KW - Aggressive behavior KW - Cortex (cingulate) KW - Social interactions KW - Decision making KW - Memory KW - Nervous system KW - Information processing KW - Social behavior KW - Neuroethology KW - Aggression KW - Excitotoxicity KW - N3 11001:Behavioral and Cognitive Neuroscience KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20640215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Neuroscience&rft.atitle=Distinct+contributions+of+frontal+areas+to+emotion+and+social+behaviour+in+the+rat&rft.au=Rudebeck%2C+Peter+H%3BWalton%2C+Mark+E%3BMillette%2C+Benjamin+HP%3BShirley%2C+Elizabeth%3BRushworth%2C+Matthew+FS%3BBannerman%2C+David+M&rft.aulast=Rudebeck&rft.aufirst=Peter&rft.date=2007-10-01&rft.volume=26&rft.issue=8&rft.spage=2315&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Neuroscience&rft.issn=0953816X&rft_id=info:doi/10.1111%2Fj.1460-9568.2007.05844.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Emotions; Neuroimaging; Anxiety; Arousal; Statistical analysis; Aggressive behavior; Cortex (frontal); Cortex (cingulate); Social interactions; Decision making; Nervous system; Memory; Information processing; Social behavior; Neuroethology; Aggression; Excitotoxicity DO - http://dx.doi.org/10.1111/j.1460-9568.2007.05844.x ER - TY - JOUR T1 - Immune Function in Young Children With Previous Pulmonary or Miliary/Meningeal Tuberculosis and Impact of BCG Vaccination AN - 20636460; 7616513 AB - OBJECTIVE. Children <5 years old are at increased risk of miliary/meningeal tuberculosis, but the immunologic factors that place them at risk are unknown. BCG vaccine protects against miliary/meningeal tuberculosis, but the mechanism of protection is unknown. We assessed for abnormalities in immune response associated with miliary/meningeal or pulmonary tuberculosis in young children. PATIENTS AND METHODS. We conducted a case-control study among HIV-seronegative Brazilian children who were <5 years old. Case subjects had previous culture-confirmed or clinical miliary/meningeal tuberculosis. There were 2 sets of control subjects: those with culture-confirmed pulmonary tuberculosis and purified protein derivative-positive household contacts. All of the children had completed treatment. Peripheral blood mononuclear cells were stimulated (phytohemagglutinin, phytohemagglutinin + interleukin 12, lipopolysaccharide, lipopolysaccharide + interferon- gamma , and purified protein derivative), and cytokine responses (interleukin 1{szligbeta}, interleukin-4, interleukin-6, interleukin-8, interleukin 10, interleukin 12, interferon- gamma , tumor necrosis factor- alpha , and monocyte chemoattractant protein 1) were quantified by bead-based assay. Median cytokine responses were compared by the Kruskal-Wallis test. Multivariate analysis of variance accounted for multiple comparisons. RESULTS. There were 18 case subjects with miliary/meningeal tuberculosis, 28 pulmonary control subjects, and 29 purified protein derivative-positive control subjects. The median age was 4.2 years. There was no difference in case and control subjects by age, gender, race, BMI, or median CD4 count. Twelve (67%) of 18 case subjects, 26 (93%) of 28 pulmonary control subjects, and 28 (97%) of 29 purified protein derivative-positive subjects had received BCG vaccine. No cytokine defects were identified in case subjects with miliary/meningeal tuberculosis compared with either set of control subjects. Pulmonary control subjects had uniformly higher monocyte chemoattractant protein 1 levels than case subjects with miliary/meningeal tuberculosis and purified protein derivative-positive control subjects, both at rest and with lipopolysaccharide, lipopolysaccharide + interferon- gamma , and purified protein derivative stimulation. Pulmonary control subjects did not have a higher frequency of allele G in the -2518 monocyte chemoattractant protein 1 promoter polymorphism. Case subjects with miliary/meningeal tuberculosis who had received BCG vaccine (n = 12) had lower stimulated interleukin 8 production than children who did not receive BCG vaccine (n = 6). CONCLUSIONS. Children with previous miliary/meningeal tuberculosis did not have a major defect in the cytokine pathways studied. Increased monocyte chemoattractant protein 1 levels were associated with pulmonary disease, occurred despite BCG vaccination, and were not associated with a polymorphism in the monocyte chemoattractant protein 1 promoter. JF - Pediatrics AU - Sterling, Timothy R AU - Martire, Terezinha AU - de Almeida, Alexandre Silva AU - Ding, Li AU - Greenberg, David E AU - Moreira, Lorena Alves AU - Elloumi, Houda AU - Torres, Angelica PV AU - Sant'Anna, Clemax Couto AU - Calazans, Eliane AU - Paraguassu, Geraldo AU - Gebretsadik, Tebeb AU - Shintani, Ayumi AU - Miller, Kathleen AU - Kritski, Afranio AU - e Silva, Jose Roberto Lapa AU - Holland, Steven M AD - Division of Infectious Diseases, Department of Medicine. Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee. Academic Tuberculosis Program, Clementino Fraga Filho University Hospital. Martagao Gesteira Pediatric Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. Division of Pediatric Pneumology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bethesda, Maryland. Department of Pediatrics, Hospital San Sebastian, Rio de Janeiro, Brazil. Department of Pediatric Neurosurgery, Hospital Sao Goncalo, Sao Goncalo, Brazil. Department of Pediatric Neurosurgery, Hospital Municipal Jesus, Rio de Janeiro, Brazil Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - e912 EP - e921 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 120 IS - 4 SN - 0031-4005, 0031-4005 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 6 KW - gamma -Interferon KW - Age KW - Interleukin 4 KW - Mycobacterium KW - Gene polymorphism KW - phytohemagglutinins KW - Interleukin 10 KW - Interleukin 8 KW - Promoters KW - Interleukin 12 KW - CD4 antigen KW - Peripheral blood mononuclear cells KW - Multivariate analysis KW - Cytokines KW - Lipopolysaccharides KW - Tuberculosis KW - Races KW - Monocyte chemoattractant protein 1 KW - Lung diseases KW - Children KW - Vaccination KW - Human immunodeficiency virus KW - BCG KW - Lung KW - Gene frequency KW - Tuberculin KW - Tumor necrosis factor- alpha KW - Vaccines KW - Immune response KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20636460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Immune+Function+in+Young+Children+With+Previous+Pulmonary+or+Miliary%2FMeningeal+Tuberculosis+and+Impact+of+BCG+Vaccination&rft.au=Sterling%2C+Timothy+R%3BMartire%2C+Terezinha%3Bde+Almeida%2C+Alexandre+Silva%3BDing%2C+Li%3BGreenberg%2C+David+E%3BMoreira%2C+Lorena+Alves%3BElloumi%2C+Houda%3BTorres%2C+Angelica+PV%3BSant%27Anna%2C+Clemax+Couto%3BCalazans%2C+Eliane%3BParaguassu%2C+Geraldo%3BGebretsadik%2C+Tebeb%3BShintani%2C+Ayumi%3BMiller%2C+Kathleen%3BKritski%2C+Afranio%3Be+Silva%2C+Jose+Roberto+Lapa%3BHolland%2C+Steven+M&rft.aulast=Sterling&rft.aufirst=Timothy&rft.date=2007-10-01&rft.volume=120&rft.issue=4&rft.spage=e912&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; gamma -Interferon; Interleukin 4; Age; Gene polymorphism; phytohemagglutinins; Interleukin 8; Interleukin 10; Interleukin 12; Promoters; Peripheral blood mononuclear cells; CD4 antigen; Multivariate analysis; Lipopolysaccharides; Cytokines; Tuberculosis; Races; Monocyte chemoattractant protein 1; Lung diseases; Children; Vaccination; Lung; BCG; Tuberculin; Gene frequency; Immune response; Vaccines; Tumor necrosis factor- alpha; Mycobacterium; Human immunodeficiency virus ER - TY - JOUR T1 - Salmonella enterica Serovar Typhi Ty21a Expressing Human Papillomavirus Type 16 L1 as a Potential Live Vaccine against Cervical Cancer and Typhoid Fever AN - 20615307; 7610248 AB - Human papillomavirus (HPV) vaccines based on L1 virus-like particles (VLPs) can prevent HPV-induced genital neoplasias, the precursors of cervical cancer. However, most cervical cancers occur in developing countries, where the implementation of expensive vaccines requiring multiple injections will be difficult. A live Salmonella-based vaccine could be a lower-cost alternative. We previously demonstrated that high HPV type 16 (HPV16)-neutralizing titers are induced after a single oral immunization of mice with attenuated Salmonella enterica serovar Typhimurium strains expressing a codon-optimized version of HPV16 L1 (L1S). To allow the testing of this type of vaccine in women, we constructed a new L1-expressing plasmid, kanL1S, and tested kanL1S recombinants of three Salmonella enterica serovar Typhi vaccine strains shown to be safe in humans, i.e., Ty21a, the actual licensed typhoid vaccine, and two highly immunogenic typhoid vaccine candidates, Ty800 and CVD908-htrA. In an intranasal mouse model of Salmonella serovar Typhi infection, Ty21a kanL1S was unique in inducing HPV16-neutralizing antibodies in serum and genital secretions, while anti-Salmonella responses were similar to those against the parental Ty21a vaccine. Electron microscopy examination of Ty21a kanL1S lysates showed that L1 assembled in capsomers and capsomer aggregates but not well-ordered VLPs. Comparison to the neutralizing antibody response induced by purified HPV16 L1 VLP immunizations in mice suggests that Ty21a kanL1S may be an effective prophylactic HPV vaccine. Ty21a has been widely used against typhoid fever in humans with a remarkable safety record. These finds encourage clinical testing of Ty21a kanL1S as a combined typhoid fever/cervical cancer vaccine with the potential for worldwide application. JF - Clinical and Vaccine Immunology AU - Fraillery, Dominique AU - Baud, David AU - Pang, Susana Yuk-Ying AU - Schiller, John AU - Bobst, Martine AU - Zosso, Nathalie AU - Ponci, Francoise AU - Nardelli-Haefliger, Denise AD - Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH-1011 Lausanne, Switzerland. Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1285 EP - 1295 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 14 IS - 10 SN - 1556-6811, 1556-6811 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Cancer vaccines KW - Virus-like particles KW - Cervical cancer KW - Secretions KW - Animal models KW - Antibody response KW - Infection KW - Plasmids KW - Immunization KW - Neoplasia KW - Recombinants KW - Combined vaccines KW - Human papillomavirus 16 KW - Salmonella enterica KW - Typhoid fever KW - Developing countries KW - Electron microscopy KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20615307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+and+Vaccine+Immunology&rft.atitle=Salmonella+enterica+Serovar+Typhi+Ty21a+Expressing+Human+Papillomavirus+Type+16+L1+as+a+Potential+Live+Vaccine+against+Cervical+Cancer+and+Typhoid+Fever&rft.au=Fraillery%2C+Dominique%3BBaud%2C+David%3BPang%2C+Susana+Yuk-Ying%3BSchiller%2C+John%3BBobst%2C+Martine%3BZosso%2C+Nathalie%3BPonci%2C+Francoise%3BNardelli-Haefliger%2C+Denise&rft.aulast=Fraillery&rft.aufirst=Dominique&rft.date=2007-10-01&rft.volume=14&rft.issue=10&rft.spage=1285&rft.isbn=&rft.btitle=&rft.title=Clinical+and+Vaccine+Immunology&rft.issn=15566811&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Virus-like particles; Secretions; Cervical cancer; Animal models; Antibody response; Plasmids; Infection; Neoplasia; Immunization; Recombinants; Combined vaccines; Typhoid fever; Developing countries; Electron microscopy; Salmonella enterica; Human papillomavirus 16 ER - TY - JOUR T1 - Geodesic Based Registration of Sensor Data and Anatomical Surface Image Data AN - 20590533; 7964313 AB - This paper presents two related methods for registering an image of an anatomical object with data from sensors arranged on the object. One method is described with reference to a test case involving a rectangular electrode plaque disposed on a heart surface, which is imaged with MRI. Data from the electrodes is fused with the MRI image at the appropriate locations. The registration scheme involves four parts. First, selected landmarks on a data surface (e.g., electrode plaque) are registered to known locations on a target anatomical surface image. Second, the anatomical surface is represented numerically with a spherical harmonic expansion. Third, given the registration of the select data surface landmarks, the location of the outer four corners of the rectangular electrode plaque are located on the anatomical surface. Fourth, a quasi-evenly spaced grid within these four corners is formed on the anatomical surface. The third and fourth steps involve calculating geodesics on the anatomical surface, preferably by utilizing the spherical harmonic expansion. According to the second registration method, spherical harmonics and geodesics are used to extract a mesh from the anatomical surface. Laplace's equation is solved on this mesh to generate a mapping from the anatomical surface to the data surface (electrode plaque). JF - Annals of Biomedical Engineering AU - Hopenfeld, Bruce AU - Ashikaga, Hiroshi AU - McVeigh, Elliot R AD - National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Dr., MSC 1061, Bethesda, MD, 20892-1061, USA, brhopenfeld@yahoo.com Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1771 EP - 1781 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 35 IS - 10 SN - 0090-6964, 0090-6964 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Mathematical models KW - Electrodes KW - Magnetic resonance imaging KW - Plaques KW - Mapping KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20590533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Biomedical+Engineering&rft.atitle=Geodesic+Based+Registration+of+Sensor+Data+and+Anatomical+Surface+Image+Data&rft.au=Hopenfeld%2C+Bruce%3BAshikaga%2C+Hiroshi%3BMcVeigh%2C+Elliot+R&rft.aulast=Hopenfeld&rft.aufirst=Bruce&rft.date=2007-10-01&rft.volume=35&rft.issue=10&rft.spage=1771&rft.isbn=&rft.btitle=&rft.title=Annals+of+Biomedical+Engineering&rft.issn=00906964&rft_id=info:doi/10.1007%2Fs10439-007-9350-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Mathematical models; Magnetic resonance imaging; Electrodes; Plaques; Mapping DO - http://dx.doi.org/10.1007/s10439-007-9350-6 ER - TY - JOUR T1 - Parent's Occupation and Isolated Orofacial Clefts in Norway: A Population-based Case-control Study AN - 20560535; 9271175 AB - Purpose Occupational factors have been associated with risk of orofacial clefts in offspring, although data are limited. We explored associations between parent's occupation and isolated orofacial clefts using a population-based case-control study. Methods Cases were restricted to infants born with an isolated orofacial cleft in Norway during the period 1996 to 2001 (314 with cleft lip with or without palate [CLP] and 118 with cleft palate only [CPO]). Controls (n = 763) were chosen randomly from all Norwegian live births. We considered full-time employment during the first 3 months of pregnancy. Results Several maternal occupations previously associated with clefts showed some evidence of association, including hairdressers (CLP; adjusted odds ratio = 4.8; 95% confidence interval [CI]: 0.99-23). Mothers working in manufacturing and in food production had increased odds for babies with CPO (3.8; 1.3-11, and 7.1; 1.5-33, respectively). Among fathers' occupations previously associated with clefts, an association was suggested for woodworking both for CLP (1.7; 0.85-3.2) and for CPO (2.0; 0.82-4.7). Fathers working as professional housekeepers showed substantial increased odds of CPO (12; 3.3-46). Conclusions Taken together with previous studies, these results suggest that exposures in certain occupations may influence the risk of orofacial clefting in offspring. Specific exposures accompanying these occupations warrant exploration. Key Words: Occupations; Cleft Lip; Cleft Palate; Abnormalities; Parents Abbreviations: aOR, adjusted odds ratio; CI, confidence interval; CLP, cleft lip with or without cleft palate; CPO, cleft palate only; OR, odds ratio JF - Annals of Epidemiology AU - Nguyen, Ruby H N AU - Wilcox, Allen J AU - Moen, Bente E AU - McConnaughey, D Robert AU - Lie, Rolv T AD - From the National Institute of Environmental Health Sciences, National Institutes of Health (R.H.N.N., A.J.W.) and Westat Inc. (D.R.M.), Durham, NC; Norwegian Institute of Public Health and the University of Bergen (B.E.M., R.T.L.) and Medical Birth Registry of Norway (R.T.L.), Bergen, Norway, nguyen5@niehs.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 763 EP - 771 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 17 IS - 10 SN - 1047-2797, 1047-2797 KW - Risk Abstracts KW - employment KW - Norway KW - offspring KW - Food production KW - Pregnancy KW - Infants KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20560535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Parent%27s+Occupation+and+Isolated+Orofacial+Clefts+in+Norway%3A+A+Population-based+Case-control+Study&rft.au=Nguyen%2C+Ruby+H+N%3BWilcox%2C+Allen+J%3BMoen%2C+Bente+E%3BMcConnaughey%2C+D+Robert%3BLie%2C+Rolv+T&rft.aulast=Nguyen&rft.aufirst=Ruby+H&rft.date=2007-10-01&rft.volume=17&rft.issue=10&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - employment; Infants; Pregnancy; Food production; offspring; Norway ER - TY - JOUR T1 - The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes AN - 20520347; 7849936 AB - Objective: S100B is produced by glia of the central and peripheral nervous systems and is considered a marker of neurologic injury in the perinatal period. Indeed, increased neonatal urine S100B concentration is associated with adverse neurological outcomes including intraventricular hemorrhage and hypoxic-ischemic encephalopathy, while elevated adult serum concentrations are associated with infectious diseases/sepsis. The objective of this study was to determine whether amniotic fluid (AF) S100B concentrations change with advancing gestational age and intra-amniotic infection (IAI).Study design: S100B concentration was measured in the AF of women in midtrimester, at term, and in pregnancies with preterm labor and intact membranes (PTL) or preterm premature rupture of membranes (PPROM), with and without IAI. Placental pathology was performed and neonatal outcomes were analyzed.Results: (1) AF S100B concentration did not change during gestation; (2) patients with IAI had significantly higher AF S100B concentration than those without IAI following an episode of PTL or PPROM and; (3) neonates who had morbidity/mortality had had an elevated AF S100B concentration; however, this could be explained by the association with intra-amniotic infection/inflammation. Thus, AF S100B concentration was not an independent predictor of neonatal morbidity or fetal/neonatal death.Conclusions: An elevated concentration of AF S100B may reflect intra-amniotic infection/inflammation and not necessarily fetal neurologic damage. JF - Journal of Perinatal Medicine AU - Friel, Lara A AU - Romero, Roberto AU - Edwin, Sam AU - Kae Nien, Jyh AU - Gomez, Ricardo AU - Chaiworapongsa, Tinnakorn AU - Pedro Kusanovic, Juan AU - Tolosa, Jorge E AU - Hassan, Sonia S AU - Espinoza, Jimmy AD - Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA, nichdprbchiefstaff@mail.nih.gov Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 385 EP - 393 PB - Walter de Gruyter und Co., Genthiner Str. 13 VL - 35 IS - 5 SN - 0300-5577, 0300-5577 KW - Microbiology Abstracts B: Bacteriology; Calcium & Calcified Tissue Abstracts KW - Chorioamnionitis KW - fetal inflammation KW - funisitis KW - interleukin-6 KW - intra-amniotic infection KW - neonatal morbidity KW - parturition KW - preterm premature rupture of membranes KW - Amniotic fluid KW - Mortality KW - S100 beta protein KW - Gestational age KW - Injuries KW - Ischemia KW - Hemorrhage KW - Infection KW - Fetuses KW - Morbidity KW - Pregnancy KW - Inflammation KW - Sepsis KW - Infectious diseases KW - Urine KW - Placenta KW - Hypoxia KW - Gestation KW - Peripheral nervous system KW - Glia KW - Neonates KW - Encephalopathy KW - Calcium-binding protein KW - T 2000:Cellular Calcium KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20520347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Perinatal+Medicine&rft.atitle=The+calcium+binding+protein%2C+S100B%2C+is+increased+in+the+amniotic+fluid+of+women+with+intra-amniotic+infection%2Finflammation+and+preterm+labor+with+intact+or+ruptured+membranes&rft.au=Friel%2C+Lara+A%3BRomero%2C+Roberto%3BEdwin%2C+Sam%3BKae+Nien%2C+Jyh%3BGomez%2C+Ricardo%3BChaiworapongsa%2C+Tinnakorn%3BPedro+Kusanovic%2C+Juan%3BTolosa%2C+Jorge+E%3BHassan%2C+Sonia+S%3BEspinoza%2C+Jimmy&rft.aulast=Friel&rft.aufirst=Lara&rft.date=2007-10-01&rft.volume=35&rft.issue=5&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=Journal+of+Perinatal+Medicine&rft.issn=03005577&rft_id=info:doi/10.1515%2FJPM.2007.101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amniotic fluid; Mortality; Gestational age; S100 beta protein; Injuries; Ischemia; Infection; Hemorrhage; Morbidity; Fetuses; Inflammation; Pregnancy; Sepsis; Infectious diseases; Urine; Hypoxia; Placenta; Gestation; Glia; Peripheral nervous system; Neonates; Encephalopathy; Calcium-binding protein DO - http://dx.doi.org/10.1515/JPM.2007.101 ER - TY - JOUR T1 - The DOMON domains are involved in heme and sugar recognition AN - 20467140; 7929322 AB - We expand the functionally uncharacterized DOMON domain superfamily to identify several novel families, including the first prokaryotic representatives. Using several computational tools we show that it is involved in ligand binding-either as heme- or sugar-binding domains. We present evidence that the DOMON domain along with the DM13 domain comprises a novel electron-transfer system potentially involved in oxidative modification of animal cell-surface proteins. Other novel versions might function as sugar sensors of histidine kinases of bacterial two component systems. CONTACT: Supplementary data are available at Bioinformatics online and also at ftp://ftp.ncbi.nih.gov/pub/aravind/domon/. JF - Bioinformatics AU - Iyer, Lakshminarayan M AU - Anantharaman, Vivek AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine and National Institute of Health, Bethesda, MD 20894, USA, aravind@ncbi.nlm.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2660 EP - 2664 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 20 SN - 1367-4803, 1367-4803 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Histidine kinase KW - Sugar KW - Data processing KW - Heme KW - Bioinformatics KW - Computer applications KW - J 02320:Cell Biology KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20467140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=The+DOMON+domains+are+involved+in+heme+and+sugar+recognition&rft.au=Iyer%2C+Lakshminarayan+M%3BAnantharaman%2C+Vivek%3BAravind%2C+L&rft.aulast=Iyer&rft.aufirst=Lakshminarayan&rft.date=2007-10-01&rft.volume=23&rft.issue=20&rft.spage=2660&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histidine kinase; Sugar; Data processing; Heme; Bioinformatics; Computer applications ER - TY - JOUR T1 - Open-to-closed transition in apo maltose-binding protein observed by paramagnetic NMR AN - 20458868; 7637879 AB - Large-scale domain rearrangements in proteins have long been recognized to have a critical function in ligand binding and recognition, catalysis and regulation. Crystal structures have provided a static picture of the apo (usually open) and holo usually closed) states. The general question arises as to whether the apo state exists as a single species in which the closed state is energetically inaccessible and interdomain rearrangement is induced by ligand or substrate binding, or whether the predominantly open form already coexists in rapid equilibrium with a minor closed species. The maltose-binding protein (MBP), a member of the bacterial periplasmic binding protein family, provides a model system for investigating this problem because it has been the subject of extensive studies by crystallography, NMR and other biophysical techniques. Here we show that although paramagnetic relaxation enhancement (PRE) data for the sugar-bound form are consistent with the crystal structure of holo MBP, the PRE data for the apo state are indicative of a rapidly exchanging mixture (ns to mus regime) of a predominantly (approx95%) open form (represented by the apo crystal structure) and a minor (approx5%) partially closed species. Using ensemble simulated annealing refinement against the PRE data we are able to determine a left fencer super(-6)right fence ensemble average structure of the minor apo species and show that it is distinct from the sugar-bound state. JF - Nature AU - Tang, Chun AU - Schwieters, Charles D AU - Clore, GMarius AD - Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1078 EP - 1082 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 449 IS - 7165 SN - 0028-0836, 0028-0836 KW - Microbiology Abstracts B: Bacteriology KW - Crystal structure KW - Crystallography KW - protein families KW - N.M.R. KW - maltose-binding protein KW - Catalysis KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20458868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Open-to-closed+transition+in+apo+maltose-binding+protein+observed+by+paramagnetic+NMR&rft.au=Tang%2C+Chun%3BSchwieters%2C+Charles+D%3BClore%2C+GMarius&rft.aulast=Tang&rft.aufirst=Chun&rft.date=2007-10-01&rft.volume=449&rft.issue=7165&rft.spage=1078&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=00280836&rft_id=info:doi/10.1038%2Fnature06232 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Crystal structure; protein families; Crystallography; N.M.R.; maltose-binding protein; Catalysis DO - http://dx.doi.org/10.1038/nature06232 ER - TY - JOUR T1 - Changes in Nucleoid Morphology and Origin Localization upon Inhibition or Alteration of the Actin Homolog, MreB, of Vibrio cholerae AN - 20435311; 7613839 AB - MreB is an actin homolog required for the morphogenesis of most rod-shaped bacteria and for other functions, including chromosome segregation. In Caulobacter crescentus and Escherichia coli, the protein seems to play a role in the segregation of sister origins, but its role in Bacillus subtilis chromosome segregation is less clear. To help clarify its role in segregation, we have here studied the protein in Vibrio cholerae, whose chromosome I segregates like the one in C. crescentus and whose chromosome II like the one in E. coli or B. subtilis. The properties of Vibrio MreB were similar to those of its homologs in other bacteria in that it formed dynamic helical filaments, was essential for viability, and was inhibited by the drug A22. Wild-type (WT) cells exposed to A22 became spherical and larger. The nucleoids enlarged correspondingly, and the origin positions for both the chromosomes no longer followed any fixed pattern. However, the sister origins separated, unlike the situation in other bacteria. In mutants isolated as A22 resistant, the nucleoids in some cases appeared compacted even when the cell shape was nearly normal. In these cells, the origins of chromosome I were at the distal edges of the nucleoid but not all the way to the poles where they normally reside. The sister origins of chromosome II also separated less. Thus, it appears that the inhibition or alteration of Vibrio MreB can affect both the nucleoid morphology and origin localization. JF - Journal of Bacteriology AU - Srivastava, Preeti AU - Demarre, Gaelle AU - Karpova, Tatiana S AU - McNally, James AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry and Molecular Biology. Laboratory of Receptor Biology and Gene Expression, NCI, NIH, Bethesda, Maryland 20892 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 7450 EP - 7463 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 20 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Bacillus subtilis KW - chromosome I KW - Morphogenesis KW - chromosome II KW - Caulobacter crescentus KW - Vibrio cholerae KW - Chromosomes KW - Cell size KW - Escherichia coli KW - Nucleoids KW - Actin KW - Filaments KW - Drugs KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20435311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Changes+in+Nucleoid+Morphology+and+Origin+Localization+upon+Inhibition+or+Alteration+of+the+Actin+Homolog%2C+MreB%2C+of+Vibrio+cholerae&rft.au=Srivastava%2C+Preeti%3BDemarre%2C+Gaelle%3BKarpova%2C+Tatiana+S%3BMcNally%2C+James%3BChattoraj%2C+Dhruba+K&rft.aulast=Srivastava&rft.aufirst=Preeti&rft.date=2007-10-01&rft.volume=189&rft.issue=20&rft.spage=7450&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chromosomes; chromosome I; Cell size; Morphogenesis; Actin; Nucleoids; chromosome II; Drugs; Filaments; Vibrio cholerae; Bacillus subtilis; Escherichia coli; Caulobacter crescentus ER - TY - JOUR T1 - Relationships between Tissue Levels of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), mRNAs, and Toxicity in the Developing Male Wistar(Han) Rat AN - 20366084; 7617560 AB - We compared the effects of a single acute dose, or chronic fetal exposure, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the male reproductive system of the Wistar(Han) rat. Tissue samples were taken from dams on gestation day (GD)16 and GD21, and from offspring on postnatal days (PND)70 and 120. Steady-state concentration of TCDD was demonstrated in the chronic study: body burdens were comparable in both studies. Fetal TCDD concentrations were comparable after acute and chronic exposure, and demonstrate more potent toxicity after chronic versus acute dosing. In maternal liver, cytochrome P450 (CYP)1A1 and CYP1A2 RNA were induced. In fetus, there was induction of both CYP1A1 and CYP1A2 RNA at medium and high doses, but inadequate evidence for induction at low dose in either study. The low level induction of CYP1A1 RNA at low dose in fetus argues against AhR activation in fetus as a mechanism of toxicity of TCDD in causing delay in balanopreputial separation (BPS), and the greater induction of CYP1A1 RNA in PND70 offspring liver from chronically-dosed dams suggests that lactational transfer of TCDD is crucial to this toxicity. These data characterize the maternal and fetal disposition of TCDD, induction of CYP1A1 RNA as a measure of AhR activation, and suggest that lactational transfer of TCDD determines the difference in delay in BPS between the two studies. JF - Toxicological Sciences AU - Bell, David R AU - Clode, Sally AU - Fan, Ming Qi AU - Fernandes, Alwyn AU - Foster, Paul MD AU - Jiang, Tao AU - Loizou, George AU - MacNicoll, Alan AU - Miller, Brian G AU - Rose, Martin AU - Tran, Lang AU - White, Shaun AD - School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom. Covance Laboratories, Ltd., Harrogate, North Yorkshire HG3 1PY, United Kingdom. NIEHS, Research Triangle Park, North Carolina 27709. Health & Safety Laboratory, Harpur Hill, Buxton, Derbyshire SK17 9JN, United Kingdom. Central Science Laboratory, Environment, Food and Health, Sand Hutton, York YO41 1LZ, United Kingdom. Institute of Occupational Medicine, Research Park North, Riccarton, Edinburgh EH14 4AP, United Kingdom Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 591 EP - 604 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - CYP1A2 protein KW - TCDD KW - Disposition KW - Toxicity KW - Reproductive system KW - Fetuses KW - mRNA KW - RNA KW - Chronic exposure KW - Gestation KW - Liver KW - Progeny KW - Cytochrome P450 KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20366084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Relationships+between+Tissue+Levels+of+2%2C3%2C7%2C8-Tetrachlorodibenzo-p-dioxin+%28TCDD%29%2C+mRNAs%2C+and+Toxicity+in+the+Developing+Male+Wistar%28Han%29+Rat&rft.au=Bell%2C+David+R%3BClode%2C+Sally%3BFan%2C+Ming+Qi%3BFernandes%2C+Alwyn%3BFoster%2C+Paul+MD%3BJiang%2C+Tao%3BLoizou%2C+George%3BMacNicoll%2C+Alan%3BMiller%2C+Brian+G%3BRose%2C+Martin%3BTran%2C+Lang%3BWhite%2C+Shaun&rft.aulast=Bell&rft.aufirst=David&rft.date=2007-10-01&rft.volume=99&rft.issue=2&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CYP1A2 protein; TCDD; Disposition; Toxicity; Fetuses; Reproductive system; mRNA; RNA; Chronic exposure; Gestation; Liver; Progeny; Cytochrome P450 ER - TY - JOUR T1 - Subchronic Toxicity and Toxicogenomic Evaluation of Tamoxifen Citrate + Bexarotene in Female Rats AN - 20364931; 7617562 AB - Tamoxifen (TAM) is a nonsteroidal antiestrogen that prevents estrogen receptor-positive breast cancer in rodents and humans. Bexarotene (BEX), a selective agonist for retinoid X receptors, inhibits mammary carcinogenesis in rodents. The present study was conducted to support the preclinical development of TAM (tamoxifen citrate) + BEX for use in breast cancer chemoprevention, and to investigate the influence of these agents on hepatic gene expression. Female CD rats (20 per group) received daily oral (gavage) exposure to TAM (0 or 60 mu g/kg/day) and/or BEX (0, 5, 15, or 45 mg/kg/day) for a minimum of 90 days. BEX induced mild, dose-related anemia and dose-related increases in serum alkaline phosphatase, cholesterol, triglycerides, and calcium levels, and increased platelet counts. TAM had no biologically significant effect on any clinical pathology parameter and did not alter the effects of BEX on these endpoints. Microscopic alterations induced by BEX included epidermal hyperplasia, hyperkeratosis (stomach), and cytoplasmic clearing (liver). Microscopic changes in TAM-treated rats were limited to mucous cell hypertrophy in the cervix and vagina. The toxicity of administration of the combination of TAM + BEX can generally be predicted on the basis of the toxicity of each drug as a single agent. BEX induced dose-related alterations in the expression of several genes involved in steroid, drug, and/or fatty acid metabolism; TAM did not alter these effects of BEX. Differential expression of genes involved in drug and lipid metabolism may underlie the observed effects of BEX on cholesterol and triglyceride levels and its effects on liver histology. JF - Toxicological Sciences AU - Horn, Thomas L AU - Torres, Karen EO AU - Naylor, Jennifer M AU - Cwik, Michael J AU - Detrisac, Carol J AU - Kapetanovic, Izet M AU - Lubet, Ronald A AU - Crowell, James A AU - McCormick, David L AD - Life Sciences Group, IIT Research Institute, Chicago, Illinois 60616. Charles River Laboratories, Inc., Pathology Associates, Chicago, Illinois 60612. Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 612 EP - 627 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 2 SN - 1096-6080, 1096-6080 KW - Toxicology Abstracts KW - Calcium KW - Gene expression KW - Triglycerides KW - tamoxifen citrate KW - Drugs KW - Estrogens KW - Drug metabolism KW - Anemia KW - Steroid hormones KW - Toxicity KW - Cholesterol KW - Antiestrogens KW - Tamoxifen KW - Retinoid X receptors KW - Lipid metabolism KW - Hyperplasia KW - Hypertrophy KW - Alkaline phosphatase KW - Carcinogenesis KW - Vagina KW - Platelets KW - Liver KW - Fatty acids KW - Breast cancer KW - Cervix KW - Stomach KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20364931?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Subchronic+Toxicity+and+Toxicogenomic+Evaluation+of+Tamoxifen+Citrate+%2B+Bexarotene+in+Female+Rats&rft.au=Horn%2C+Thomas+L%3BTorres%2C+Karen+EO%3BNaylor%2C+Jennifer+M%3BCwik%2C+Michael+J%3BDetrisac%2C+Carol+J%3BKapetanovic%2C+Izet+M%3BLubet%2C+Ronald+A%3BCrowell%2C+James+A%3BMcCormick%2C+David+L&rft.aulast=Horn&rft.aufirst=Thomas&rft.date=2007-10-01&rft.volume=99&rft.issue=2&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Calcium; Gene expression; Triglycerides; tamoxifen citrate; Drugs; Estrogens; Drug metabolism; Anemia; Cholesterol; Toxicity; Steroid hormones; Tamoxifen; Antiestrogens; Lipid metabolism; Retinoid X receptors; Hypertrophy; Hyperplasia; Alkaline phosphatase; Vagina; Carcinogenesis; Fatty acids; Liver; Platelets; Breast cancer; Cervix; Stomach ER - TY - JOUR T1 - Information Flow in Interaction Networks AN - 20360642; 7647624 AB - Interaction networks, consisting of agents linked by their interactions, are ubiquitous accross many disciplines of modern science. Many methods of analysis of interaction networks have been proposed, mainly concentrating on node degree distribution or aiming to discover clusters of agents that are very strongly connected between themselves. These methods are principally based on graph-theory or machine learning. We present a mathematically simple formalism for modelling context-specific information propagation in interaction networks based on random walks. The context is provided by selection of sources and destinations of information and by use of potential functions that direct the flow towards the destinations. We also use the concept of dissipation to model the aging of information as it diffuses from its source. Using examples from yeast protein-protein interaction networks and some of the histone acetyltransferases involved in control of transcription, we demonstrate the utility of the concepts and the mathematical constructs introduced in this paper. JF - Journal of Computational Biology AU - Stojmirovic, A AU - Yu, Y-K AD - NCBI/NLM, National Institutes of Health, 8600 Rockville Pike, Bethesda, MD 20894, USA, yyu@ncbi.nlm.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1115 EP - 1143 VL - 14 IS - 8 SN - 1066-5277, 1066-5277 KW - Biotechnology and Bioengineering Abstracts KW - Mathematical models KW - Histone acetyltransferase KW - Aging KW - Transcription KW - Learning algorithms KW - Computer applications KW - Protein interaction KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20360642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Computational+Biology&rft.atitle=Information+Flow+in+Interaction+Networks&rft.au=Stojmirovic%2C+A%3BYu%2C+Y-K&rft.aulast=Stojmirovic&rft.aufirst=A&rft.date=2007-10-01&rft.volume=14&rft.issue=8&rft.spage=1115&rft.isbn=&rft.btitle=&rft.title=Journal+of+Computational+Biology&rft.issn=10665277&rft_id=info:doi/10.1089%2Fcmb.2007.0069 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; Histone acetyltransferase; Aging; Transcription; Learning algorithms; Computer applications; Protein interaction DO - http://dx.doi.org/10.1089/cmb.2007.0069 ER - TY - JOUR T1 - A canine model of septic shock: balancing animal welfare and scientific relevance AN - 20343962; 7608676 AB - A shock canine pneumonia model that permitted relief of discomfort with the use of objective criteria was developed and validated. After intrabronchial Staphylococcus aureus challenge, mechanical ventilation, antibiotics, fluids, vasopressors, sedatives, and analgesics were titrated based on algorithms for 96 h. Increasing S. aureus (1 to 8 x 10 super(9) colony-forming units/kg) produced decreasing survival rates (P = 0.04). From 4 to 96 h, changes in arterial-alveolar oxygen gradients, mean pulmonary artery pressure, IL-1, serum sodium levels, mechanical ventilation, and vasopressor support were ordered based on survival time [acute nonsurvivors ( less than or equal to 24 h until death, n = 8) greater than or equal to subacute nonsurvivors (>24 to 96 h until death, n = 8) greater than or equal to survivors ( greater than or equal to 96 h until death, n = 22) (all P < 0.05)]. In the first 12 h, increases in lactate and renal abnormalities were greatest in acute nonsurvivors (all P < 0.05). Compared with survivors, subacute nonsurvivors had greater rises in cytokines and liver enzymes and greater falls in platelets, white cell counts, pH, and urine output from 24 to 96 h (all P < 0.05). Importantly, these changes were not attributable to dosages of sedation, which decreased in nonsurvivors [survivors vs. nonsurvivors: 5.0 plus or minus 1.0 vs. 3.8 plus or minus 0.7 ml.h super(-1).(fentanyl/midazolam/ medetomidine) super(-1); P = 0.02]. In this model, the pain control regimen did not mask changes in metabolic function and lung injury or the need for more hemodynamic and pulmonary support related to increasing severity of sepsis. The integration into this model of both specific and supportive titrated therapies routinely used in septic patients may provide a more realistic setting to evaluate therapies for sepsis. JF - American Journal of Physiology: Cell Physiology AU - Minneci, Peter C AU - Deans, Katherine J AU - Hansen, Bernie AU - Parent, Chantal AU - Romines, Chris AU - Gonzales, Denise A AU - Ying, Sai-Xia AU - Munson, Peter AU - Suffredini, Anthony F AU - Feng, Jing AU - Solomon, Michael A AU - Banks, Steven M AU - Kern, Steven J AU - Danner, Robert L AU - Eichacker, Peter Q AU - Natanson, Charles AU - Solomon, Steven B AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - H2487 EP - H2500 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 293 IS - 4 SN - 0363-6143, 0363-6143 KW - Microbiology Abstracts B: Bacteriology KW - Injuries KW - Ventilation KW - Interleukin 1 KW - Algorithms KW - Survival KW - Hemodynamics KW - Antibiotics KW - Pain KW - Integration KW - Sedatives KW - Cytokines KW - Analgesics KW - Staphylococcus aureus KW - Pressure KW - pH effects KW - Animal welfare KW - Enzymes KW - Septic shock KW - Sodium KW - midazolam KW - Oxygen KW - Sepsis KW - Urine KW - Lung KW - Pulmonary artery KW - Liver KW - Platelets KW - Lactic acid KW - Kidney KW - Pneumonia KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20343962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Cell+Physiology&rft.atitle=A+canine+model+of+septic+shock%3A+balancing+animal+welfare+and+scientific+relevance&rft.au=Minneci%2C+Peter+C%3BDeans%2C+Katherine+J%3BHansen%2C+Bernie%3BParent%2C+Chantal%3BRomines%2C+Chris%3BGonzales%2C+Denise+A%3BYing%2C+Sai-Xia%3BMunson%2C+Peter%3BSuffredini%2C+Anthony+F%3BFeng%2C+Jing%3BSolomon%2C+Michael+A%3BBanks%2C+Steven+M%3BKern%2C+Steven+J%3BDanner%2C+Robert+L%3BEichacker%2C+Peter+Q%3BNatanson%2C+Charles%3BSolomon%2C+Steven+B&rft.aulast=Minneci&rft.aufirst=Peter&rft.date=2007-10-01&rft.volume=293&rft.issue=4&rft.spage=H2487&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Cell+Physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ventilation; Injuries; Interleukin 1; Algorithms; Hemodynamics; Survival; Pain; Antibiotics; Integration; Sedatives; Cytokines; Analgesics; Pressure; pH effects; Animal welfare; Enzymes; Septic shock; midazolam; Sodium; Oxygen; Sepsis; Lung; Urine; Pulmonary artery; Kidney; Lactic acid; Platelets; Liver; Pneumonia; Staphylococcus aureus ER - TY - JOUR T1 - Genetic variation tracks ecological segregation in Pacific island black flies AN - 20343055; 7611949 AB - Geographic isolation is widely viewed as a key component of insular radiations on islands. However, strong ecological affinities may also reinforce isolation and promote genetic divergence. The black fly fauna in the Society Islands French Polynesia is notable for the number of closely related endemic species (31), and the morphological and habitat diversity of the larvae. Here, we measure ecological and morphological differences within and between two closely related species, Simulium oviceps and Simulium dussertorum and relate these differences to genetic distance. Phylogenetic analyses of a 920 bp fragment of the cytochrome oxidase I (COI) gene revealed a well-supported, ecologically divergent S. oviceps clade (larvae found in rivers instead of cascades) that shows little morphological differentiation. For both S. oviceps and S. dussertorum, genetic distance among populations is related to larval habitat, with cascade populations showing greater isolation from each other than river populations. Our data support the hypothesis that larval ecological shifts have played a role in the radiation of this black fly fauna. JF - Heredity AU - Joy, D A AU - Craig, D A AU - Conn, J E AD - Department of Biology, University of Vermont, Burlington, VT, USA, djoy@niaid.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 452 EP - 459 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 99 IS - 4 SN - 0018-067X, 0018-067X KW - Ecology Abstracts; ASFA Marine Biotechnology Abstracts; Entomology Abstracts; Genetics Abstracts KW - insular radiation KW - habitat shift KW - mitochondrial DNA KW - simuliidae KW - island biogeography KW - Phylogeny KW - Rivers KW - Simulium KW - Data processing KW - Cytochrome oxidase I KW - Genetic diversity KW - Habitat KW - Population genetics KW - Differentiation KW - Endemic species KW - Islands KW - Genetic distance KW - COI protein KW - D 04040:Ecosystem and Ecology Studies KW - Q4 27700:Molecular Techniques KW - Z 05360:Genetics and Evolution KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20343055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Heredity&rft.atitle=Genetic+variation+tracks+ecological+segregation+in+Pacific+island+black+flies&rft.au=Joy%2C+D+A%3BCraig%2C+D+A%3BConn%2C+J+E&rft.aulast=Joy&rft.aufirst=D&rft.date=2007-10-01&rft.volume=99&rft.issue=4&rft.spage=452&rft.isbn=&rft.btitle=&rft.title=Heredity&rft.issn=0018067X&rft_id=info:doi/10.1038%2Fsj.hdy.6801023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Rivers; Phylogeny; Differentiation; Population genetics; Endemic species; Data processing; Islands; Genetic diversity; Cytochrome oxidase I; COI protein; Genetic distance; Habitat; Simulium DO - http://dx.doi.org/10.1038/sj.hdy.6801023 ER - TY - JOUR T1 - Adverse Birth Outcome Among Mothers With Low Serum Cholesterol AN - 20324604; 7616439 AB - OBJECTIVE. The objective of this study was to assess whether low maternal serum cholesterol during pregnancy is associated with preterm delivery, impaired fetal growth, or congenital anomalies in women without identified major risk factors for adverse pregnancy outcome. METHODS. Mother-infant pairs were retrospectively ascertained from among a cohort of 9938 women who were referred to South Carolina prenatal clinics for routine second-trimester serum screening. Banked sera were assayed for total cholesterol; 10th percentile but <90th percentile. RESULTS. Prevalence of preterm delivery among mothers with low total cholesterol was 12.7%, compared with 5.0% among control subjects with mid-total cholesterol. The association of low maternal serum cholesterol with preterm birth was observed only among white mothers. Term infants of mothers with low total cholesterol weighed on average 150 g less than those who were born to control mothers. A trend of increased microcephaly risk among neonates of mothers with low total cholesterol was found. Low maternal serum cholesterol was unassociated with risk for congenital anomalies. CONCLUSIONS. Total serum cholesterol <10th population percentile was strongly associated with preterm delivery among otherwise low-risk white mothers in this pilot study population. Term infants of mothers with low total cholesterol weighed less than control infants among both racial groups. JF - Pediatrics AU - Edison, Robin J AU - Berg, Kate AU - Remaley, Alan AU - Kelley, Richard AU - Rotimi, Charles AU - Stevenson, Roger E AU - Muenke, Maximilian AD - Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland. National Institutes of Health Clinical Center, Bethesda, Maryland. Kennedy Krieger Institute, Baltimore, Maryland. National Human Genome Research Center, Howard University, Washington, DC. Greenwood Genetic Center, Greenwood, South Carolina Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 723 EP - 733 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 120 IS - 4 SN - 0031-4005, 0031-4005 KW - cholesterol KW - Risk Abstracts KW - diabetes mellitus KW - USA, South Carolina KW - Congenital defects KW - Neonates KW - Infants KW - Pregnancy KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20324604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Adverse+Birth+Outcome+Among+Mothers+With+Low+Serum+Cholesterol&rft.au=Edison%2C+Robin+J%3BBerg%2C+Kate%3BRemaley%2C+Alan%3BKelley%2C+Richard%3BRotimi%2C+Charles%3BStevenson%2C+Roger+E%3BMuenke%2C+Maximilian&rft.aulast=Edison&rft.aufirst=Robin&rft.date=2007-10-01&rft.volume=120&rft.issue=4&rft.spage=723&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - diabetes mellitus; Congenital defects; Neonates; Pregnancy; Infants; USA, South Carolina ER - TY - JOUR T1 - Dietary Supplement Use Among Infants, ildren, and Adolescents in the United States, 1999-2002 AN - 20311606; 7609311 AB - OBJECTIVE: To describe dietary supplement use among US children. DESIGN: Analysis of nationally representative data from the 1999-2002 National Health and Nutrition Examination Survey (NHANES). SETTING: Home interviews and a mobile examination center. PARTICIPANTS: Children from birth through 18 years who participated in NHANES (N = 10 136). Main Exposure Frequency of use of any dietary supplement product. Outcome Measure Prevalence of use and intake of key nutrients from supplements among children. RESULTS: In 1999-2002, 31.8% of children used dietary supplements, with the lowest use reported among infants younger than 1 year (11.9%) and teenagers 14 to 18 years old (25.7%) and highest use among 4- to 8-year-old children (48.5%). Use was highest among non-Hispanic white (38.1%) and Mexican American (22.4%) participants, lowest among non-Hispanic black participants (18.8%), and was not found to differ by sex. The type of supplement most commonly used was multivitamins and multiminerals (18.3%). Ascorbic acid (28.6%), retinol (25.8%), vitamin D (25.6%), calcium (21.1%), and iron (19.3%) were the primary supplemental nutrients consumed. Supplement use was associated with families with higher incomes; a smoke-free environment; not being certified by the US Department of Agriculture Special Supplemental Nutrition Program for Women, Infants and Children in the last 12 months; lower child body mass index; and less daily recreational screen time (television, video games, computers, etc) (P < .005). The highest prevalence of supplement use (P < .005) was in children who were underweight or at risk for underweight (P < .005). CONCLUSIONS: More than 30% of children in the United States take dietary supplements regularly, most often multivitamins and multiminerals. Given such extensive use, nutrient intakes from dietary supplements must be included to obtain accurate estimates of overall nutrient intake in children. JF - Archives of Pediatrics & Adolescent Medicine AU - Picciano, Mary Frances AU - Dwyer, Johanna T AU - Radimer, Kathy L AU - Wilson, David H AU - Fisher, Kenneth D AU - Thomas, Paul R AU - Yetley, Elizabeth A AU - Moshfegh, Alanna J AU - Levy, Paul S AU - Nielsen, Samara Joy AU - Marriott, Bernadette M AD - Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland (Drs Picciano, Dwyer, Fisher, Thomas, and Yetley) Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 978 EP - 985 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 161 IS - 10 SN - 1072-4710, 1072-4710 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20311606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.atitle=Dietary+Supplement+Use+Among+Infants%2C+ildren%2C+and+Adolescents+in+the+United+States%2C+1999-2002&rft.au=Picciano%2C+Mary+Frances%3BDwyer%2C+Johanna+T%3BRadimer%2C+Kathy+L%3BWilson%2C+David+H%3BFisher%2C+Kenneth+D%3BThomas%2C+Paul+R%3BYetley%2C+Elizabeth+A%3BMoshfegh%2C+Alanna+J%3BLevy%2C+Paul+S%3BNielsen%2C+Samara+Joy%3BMarriott%2C+Bernadette+M&rft.aulast=Picciano&rft.aufirst=Mary&rft.date=2007-10-01&rft.volume=161&rft.issue=10&rft.spage=978&rft.isbn=&rft.btitle=&rft.title=Archives+of+Pediatrics+%26+Adolescent+Medicine&rft.issn=10724710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2011-12-13 ER - TY - JOUR T1 - Cell Surface Filaments of the Gliding Bacterium Flavobacterium johnsoniae Revealed by Cryo-Electron Tomography AN - 20311003; 7613844 AB - Flavobacterium johnsoniae cells glide rapidly over surfaces by an as-yet-unknown mechanism. Using cryo-electron tomography, we show that wild-type cells display tufts of similar to 5-nm-wide cell surface filaments that appear to be anchored to the inner surface of the outer membrane. These filaments are absent in cells of a nonmotile gldF mutant but are restored upon expression of plasmid-encoded GldF, a component of a putative ATP-binding cassette transporter. JF - Journal of Bacteriology AU - Liu, Jun AU - McBride, Mark J AU - Subramaniam, Sriram AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Department of Biological Sciences, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 7503 EP - 7506 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 189 IS - 20 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Flavobacterium johnsoniae KW - Cell surface KW - Gliding KW - ATP-binding protein KW - Outer membranes KW - Tomography KW - Filaments KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20311003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Cell+Surface+Filaments+of+the+Gliding+Bacterium+Flavobacterium+johnsoniae+Revealed+by+Cryo-Electron+Tomography&rft.au=Liu%2C+Jun%3BMcBride%2C+Mark+J%3BSubramaniam%2C+Sriram&rft.aulast=Liu&rft.aufirst=Jun&rft.date=2007-10-01&rft.volume=189&rft.issue=20&rft.spage=7503&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Gliding; ATP-binding protein; Outer membranes; Tomography; Filaments; Flavobacterium johnsoniae ER - TY - JOUR T1 - Enzyme Replacement in Fabry Disease: Pharmacokinetics and Pharmacodynamics of Agalsidase Alfa in Children and Adolescents AN - 20310611; 7614588 AB - This multicenter, open-label study evaluated pharmacokinetics, pharmacodynamics, and safety of agalsidase alfa in pediatric compared with adult patients with Fabry disease. The pharmacokinetic parameters of pediatric patients (19 boys, 5 girls, 6-18 years old; mean age, 11.8 years) were compared to those of adult male and female patients who participated in other clinical studies. All patients received agalsidase alfa at a dose of 0.2 mg/kg infused over 40 minutes every other week. Agalsidase alfa exhibited a biphasic serum elimination profile with a maximum serum concentration at the end of the 40-minute infusion; <1% of the maximum concentration was detected 8 hours after dosing. In children, serum clearance was 2.0 to 9.4 mL/min/kg and tended to decrease with increasing age. The average clearance in children, 3.7 plus or minus 1.5 mL/min/kg (mean plus or minus SD), was significantly greater than that measured in 33 adults (2.3 plus or minus 0.7 mL/min/kg, P < .0001). Mean terminal elimination half-life of agalsidase alfa was prolonged in week 25 compared with baseline (150 vs 66 minutes) in 8 of 19 male children. The magnitude of the reduction of plasma globotriaosylceremide was similar in all age groups and was independent of area under the curve and other pharmacokinetic parameters. Except for clearance in younger patients, agalsidase alfa appears to have comparable pharmacokinetic and pharmacodynamic profiles in pediatric and adult Fabry patients of both genders. JF - Journal of Clinical Pharmacology AU - Ries, Markus AU - Clarke, Joe T AU - Whybra, Catharina AU - Mehta, Atul AU - Loveday, Kenneth S AU - Brady, Roscoe O AU - Beck, Michael AU - Schiffmann, Raphael AD - Developmental and Metabolic Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland (Dr Ries, Dr Brady, Dr Schiffmann) Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1222 EP - 1230 PB - Sage Publications, Inc., 2455 Teller Road Thousand Oaks CA 91320 USA, [mailto:info@sagepub.com], [URL:http://www.sagepub.com/] VL - 47 IS - 10 SN - 0091-2700, 0091-2700 KW - agalsidase alfa KW - Health & Safety Science Abstracts KW - age groups KW - Gender KW - Enzymes KW - Hormone replacement therapy KW - Children KW - Pharmacokinetics KW - Adolescents KW - Side effects KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20310611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Pharmacology&rft.atitle=Enzyme+Replacement+in+Fabry+Disease%3A+Pharmacokinetics+and+Pharmacodynamics+of+Agalsidase+Alfa+in+Children+and+Adolescents&rft.au=Ries%2C+Markus%3BClarke%2C+Joe+T%3BWhybra%2C+Catharina%3BMehta%2C+Atul%3BLoveday%2C+Kenneth+S%3BBrady%2C+Roscoe+O%3BBeck%2C+Michael%3BSchiffmann%2C+Raphael&rft.aulast=Ries&rft.aufirst=Markus&rft.date=2007-10-01&rft.volume=47&rft.issue=10&rft.spage=1222&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Pharmacology&rft.issn=00912700&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - age groups; Gender; Enzymes; Hormone replacement therapy; Children; Side effects; Adolescents; Pharmacokinetics ER - TY - JOUR T1 - Oxygen-Uptake Efficiency Slope as a Determinant of Fitness in Overweight Adolescents AN - 20308512; 7626117 AB - Purpose: Peak oxygen uptake (VO sub(2peak)) is frequently difficult to assess in overweight individuals; therefore, submaximal measures that predict VO sub(2peak) are proposed as substitutes. Oxygen uptake efficiency slope (OUES) has been suggested as a submaximal measurement of cardiorespiratory fitness that is independent of exercise intensity. There are few data examining its value as a predictor of VO sub(2peak) in severely overweight adolescents. Methods: One hundred seven severely overweight (BMI Z 2.50 plus or minus 0.34) and 43 nonoverweight (BMI Z 0.13 plus or minus 0.84) adolescents, performed a maximal cycle ergometer test with respiratory gas-exchange measurements. OUES was calculated through three exercise intensities: lactate inflection point (OUES LI), 150% of lactate inflection point (OUES 150), and VO sub(2peak) (OUES PEAK). Results: When adjusted for lean body mass, VO sub(2peak) and OUES at all exercise intensities were lower in overweight subjects (VO sub(2peak): 35.3 plus or minus 6.4 vs 46.8 plus or minus 7.9 mL times kg super(-1) LBM times min super(-1), P < 0.001; OUES LI: 37.9 plus or minus 10.0 vs 43.7 plus or minus 9.2 mL times kg super(-1) LBM times min super(-1) times logL super(-1) P < 0.001; OUES 150:41.6 plus or minus 9.0 vs 49.8 plus or minus 11.1 mL times kg super(-1) LBM times min super(-1) times logL super(-1) P < 0.001; and OUES PEAK: 45.1 plus or minus 8.7 vs 52.8 plus or minus 9.6 mL times kg super(-1) LBM times min super(-1) times logL super(-1) P < 0.001). There was a significant increase in OUES with increasing exercise intensity in both groups (P < 0.001). OUES at all exercise intensities was a significant predictor of VO sub(2peak) for both groups (r super(2) = 0.35-0.83, P < 0.0001). However, limits of agreement for predicted VO sub(2peak) relative to actual VO sub(2peak) were wide ( plus or minus 478 to plus or minus 670 mL times min super(-1)). Conclusions: OUES differs significantly in overweight and nonoverweight adolescents. The wide interindividual variation and the exercise intensity dependence of OUES preclude its use in clinical practice as a predictor of VO sub(2peak). JF - Medicine & Science in Sports & Exercise AU - Drinkard, B AU - Roberts, MD AU - Ranzenhofer, L M AU - Han, J C AU - Yanoff, L B AU - Merke, D P AU - Savastano, D M AU - Brady, S AU - Yanovski, JA AD - Unit on Growth and Obesity, DEB, NICHD, National Institutes of Health, Building CRC Room 1-1330, 10 Center Drive MSC 1103, Bethesda, MD 208921103, USA, yanovskj@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1811 EP - 1816 VL - 39 IS - 10 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - Fitness KW - Obesity KW - Measurement KW - Efficiency KW - Exercise (intensity) KW - Adolescence KW - Body mass KW - Lactic acid KW - Sport science KW - Cardiorespiratory KW - Maximum oxygen consumption KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20308512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=Oxygen-Uptake+Efficiency+Slope+as+a+Determinant+of+Fitness+in+Overweight+Adolescents&rft.au=Drinkard%2C+B%3BRoberts%2C+MD%3BRanzenhofer%2C+L+M%3BHan%2C+J+C%3BYanoff%2C+L+B%3BMerke%2C+D+P%3BSavastano%2C+D+M%3BBrady%2C+S%3BYanovski%2C+JA&rft.aulast=Drinkard&rft.aufirst=B&rft.date=2007-10-01&rft.volume=39&rft.issue=10&rft.spage=1811&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2Fmss.0b013e31812e52b3 LA - English DB - Physical Education Index N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fitness; Measurement; Obesity; Efficiency; Exercise (intensity); Body mass; Adolescence; Lactic acid; Sport science; Cardiorespiratory; Maximum oxygen consumption DO - http://dx.doi.org/10.1249/mss.0b013e31812e52b3 ER - TY - JOUR T1 - Mitochondrial DNA Sequence Heterogeneity of Single CD34 super(+) Cells After Nonmyeloablative Allogeneic Stem Cell Transplantation AN - 20302525; 7617376 AB - We applied a single-cell method to detect mitochondrial DNA (mtDNA) mutations to evaluate the reconstitution of hematopoietic stem cells (HSCs) and committed progenitor cells after nonmyeloablative allogeneic stem cell transplantation in humans. In a total of 1,958 single CD34 super(+) cells from six human leukocyte antigen-matched sibling donor and recipient pairs, individual CD34 super(+) clones were recognized based on the observed donor- or recipient-specific mtDNA sequence somatic alteration. There was no overall reduction of mtDNA heterogeneity among CD34 super(+) cells from the recipient after transplantation. Samples collected from two donors over time showed the persistence of certain CD34 super(+) clones marked by specific mutations. Our results demonstrate the feasibility of distinguishing donor and recipient individual CD34 super(+) clones based on mtDNA mutations during engraftment. HSCs were not limited in number, and similar mtDNA heterogeneity levels suggested representation of the total stem cell compartment during rapid hematopoietic reconstitution in the recipient. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Yao, Yong-Gang AU - Childs, Richard W AU - Kajigaya, Sachiko AU - McCoy, JPhilip Jr AU - Young, Neal S AD - Hematology Branch and Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2670 EP - 2676 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 10 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Mitochondrial DNA KW - Donors KW - Stem cells KW - stem cell transplantation KW - Leukocytes KW - Hemopoiesis KW - CD34 antigen KW - Siblings KW - Mutation KW - W 30905:Medical Applications KW - N 14815:Nucleotide Sequence KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20302525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Mitochondrial+DNA+Sequence+Heterogeneity+of+Single+CD34+super%28%2B%29+Cells+After+Nonmyeloablative+Allogeneic+Stem+Cell+Transplantation&rft.au=Yao%2C+Yong-Gang%3BChilds%2C+Richard+W%3BKajigaya%2C+Sachiko%3BMcCoy%2C+JPhilip+Jr%3BYoung%2C+Neal+S&rft.aulast=Yao&rft.aufirst=Yong-Gang&rft.date=2007-10-01&rft.volume=25&rft.issue=10&rft.spage=2670&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stem cells; Donors; Mitochondrial DNA; stem cell transplantation; Leukocytes; Hemopoiesis; Siblings; CD34 antigen; Mutation ER - TY - JOUR T1 - Continuous Wave EPR Oximetric Imaging at 300 MHz Using Radiofrequency Power Saturation Effects AN - 20280017; 7624731 AB - A novel continuous wave (CW), radiofrequency (RF), electron paramagnetic resonance (EPR) oximetric imaging technique is proposed, based on the influence of oxygen concentration on the RF power saturation of the EPR resonance. A linear relationship is demonstrated between the partial oxygen pressure (pO sub(2)) and the normalized signal intensity (I sub(N)), defined as, I sub(N) = (I sub(HP) - I sub(LP))/I sub(LP), where I sub(LP) and I sub(HP) refer to signal intensities at low (P sub(L)) and high (P sub(H)) RF power levels, respectively. A formula for the determination of pO sub(2), derived on the basis of the experimental results, reliably estimated various oxygen concentrations in a five-tube phantom. This new technique was time-efficient and also avoided the missing angle problem associated with conventional spectral-spatial CW EPR oximetric imaging. In vivo power saturation oximetric imaging in a tumor bearing mouse clearly depicted the hypoxic foci within the tumor. JF - Antioxidants and Redox Signaling AU - Hama, Y AU - Matsumoto, K-I AU - Murugesan, R AU - Subramanian, S AU - Devasahayam, N AU - Koscielniak, J W AU - Hyodo, F AU - Cook, JA AU - Mitchell, J B AU - Krishna, M C AD - Building 10, Room B3-B69, National Institutes of Health, Bethesda, MD 20892-1002, USA, murali@helix.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1709 EP - 1716 VL - 9 IS - 10 SN - 1523-0864, 1523-0864 KW - Biotechnology and Bioengineering Abstracts KW - E.S.R. KW - Oxygen KW - Antioxidants KW - Hypoxia KW - Tumors KW - Pressure KW - imaging KW - Signal transduction KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20280017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antioxidants+and+Redox+Signaling&rft.atitle=Continuous+Wave+EPR+Oximetric+Imaging+at+300+MHz+Using+Radiofrequency+Power+Saturation+Effects&rft.au=Hama%2C+Y%3BMatsumoto%2C+K-I%3BMurugesan%2C+R%3BSubramanian%2C+S%3BDevasahayam%2C+N%3BKoscielniak%2C+J+W%3BHyodo%2C+F%3BCook%2C+JA%3BMitchell%2C+J+B%3BKrishna%2C+M+C&rft.aulast=Hama&rft.aufirst=Y&rft.date=2007-10-01&rft.volume=9&rft.issue=10&rft.spage=1709&rft.isbn=&rft.btitle=&rft.title=Antioxidants+and+Redox+Signaling&rft.issn=15230864&rft_id=info:doi/10.1089%2Fars.2007.1720 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - E.S.R.; Oxygen; Antioxidants; Hypoxia; Tumors; Pressure; imaging; Signal transduction DO - http://dx.doi.org/10.1089/ars.2007.1720 ER - TY - JOUR T1 - Inhibitors of Ubiquitin-Activating Enzyme (E1), a New Class of Potential Cancer Therapeutics AN - 20276124; 7610169 AB - The conjugation of proteins with ubiquitin plays numerous regulatory roles through both proteasomal-dependent and nonproteasomal-dependent functions. Alterations in ubiquitylation are observed in a wide range of pathologic conditions, including numerous malignancies. For this reason, there is great interest in targeting the ubiquitin-proteasome system in cancer. Several classes of proteasome inhibitors, which block degradation of ubiquitylated proteins, are widely used in research, and one, Bortezomib, is now in clinical use. Despite the well-defined and central role of the ubiquitin-activating enzyme (E1), no cell permeable inhibitors of E1 have been identified. Such inhibitors should, in principle, block all functions of ubiquitylation. We now report 4[4-(5-nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl]-benz o ic acid ethyl ester (PYR-41) as the first such inhibitor. Unexpectedly, in addition to blocking ubiquitylation, PYR-41 increased total sumoylation in cells. The molecular basis for this is unknown; however, increased sumoylation was also observed in cells harboring temperature-sensitive E1. Functionally, PYR-41 attenuates cytokine-mediated nuclear factor- Kappa B activation. This correlates with inhibition of nonproteasomal (Lys-63) ubiquitylation of TRAF6, which is essential to I Kappa B kinase activation. PYR-41 also prevents the downstream ubiquitylation and proteasomal degradation of I Kappa B alpha . Furthermore, PYR-41 inhibits degradation of p53 and activates the transcriptional activity of this tumor suppressor. Consistent with this, it differentially kills transformed p53-expressing cells. Thus, PYR-41 and related pyrazones provide proof of principle for the capacity to differentially kill transformed cells, suggesting the potential for E1 inhibitors as therapeutics in cancer. These inhibitors can also be valuable tools for studying ubiquitylation. [Cancer Res 2007; 67(19):9472-81] JF - Cancer Research AU - Yang, Yili AU - Kitagaki, Jirouta AU - Dai, Ren-Ming AU - Tsai, Yien Che AU - Lorick, Kevin L AU - Ludwig, Robert L AU - Pierre, Shervon A AU - Jensen, Jane P AU - Davydov, Ilia V AU - Oberoi, Pankaj AU - Li, Chou-Chi H AU - Kenten, John H AU - Beutler, John A AU - Vousden, Karen H AU - Weissman, Allan M AD - Laboratory of Protein Dynamics and Signaling, Laboratory of Cancer Prevention, and Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute at Frederick, NIH, Frederick, Maryland Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 9472 EP - 9481 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 19 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Tumor suppressor genes KW - Transformed cells KW - TRAF6 protein KW - SUMO protein KW - proteasomes KW - Transcription KW - Enzymes KW - Esters KW - Cancer KW - p53 protein KW - Malignancy KW - I^KB kinase KW - proteasome inhibitors KW - Ubiquitin KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20276124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Inhibitors+of+Ubiquitin-Activating+Enzyme+%28E1%29%2C+a+New+Class+of+Potential+Cancer+Therapeutics&rft.au=Yang%2C+Yili%3BKitagaki%2C+Jirouta%3BDai%2C+Ren-Ming%3BTsai%2C+Yien+Che%3BLorick%2C+Kevin+L%3BLudwig%2C+Robert+L%3BPierre%2C+Shervon+A%3BJensen%2C+Jane+P%3BDavydov%2C+Ilia+V%3BOberoi%2C+Pankaj%3BLi%2C+Chou-Chi+H%3BKenten%2C+John+H%3BBeutler%2C+John+A%3BVousden%2C+Karen+H%3BWeissman%2C+Allan+M&rft.aulast=Yang&rft.aufirst=Yili&rft.date=2007-10-01&rft.volume=67&rft.issue=19&rft.spage=9472&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Ubiquitin; Enzymes; proteasomes; SUMO protein; Esters; Malignancy; p53 protein; Transcription; I^KB kinase; TRAF6 protein; Tumor suppressor genes; Transformed cells; proteasome inhibitors ER - TY - JOUR T1 - Potent carcinogenicity of cigarette smoke in mice exposed early in life AN - 20274674; 7610209 AB - In spite of the dominant role of cigarette smoke (CS) in cancer epidemiology, all studies performed during the past 60 years have shown that this complex mixture is either negative or weakly tumorigenic in experimental animals. We implemented studies aimed at evaluating whether exposure of mice early in life may enhance susceptibility to CS carcinogenicity. A total of 98 newborn Swiss albino mice were either untreated (controls) or received a subcutaneous injection of benzo(a)pyrene [B(a)P] (positive control) or were exposed whole-body to mainstream cigarette smoke (MCS) for 120 days, starting within 12 h after birth. Complete necropsy and histopathological analyses were performed at periodical intervals. In contrast with the lack of lung tumors in controls, MCS-exposed mice developed microscopically detectable tumors, starting only 75 days after birth and reaching an overall incidence of 78.3% after 181-230 days. The mean lung tumor multiplicities were 6.1 and 13.6 tumors per mouse in males and females, respectively, showing a significant intergender difference. Most tumors were microadenomas or adenomas, but 18.4% of the mice additionally had malignant lung cancer. MCS also induced bronchial and alveolar epithelial hyperplasia, and blood vessel proliferation. Furthermore, malignant tumors, some of which may have a metastatic origin, were detected in the urinary tract and liver of MCS-exposed mice. A somewhat different spectrum of tumors was observed in B(a)P-treated mice. In conclusion, MCS is a potent and broad spectrum carcinogen in mice when exposure starts early in life, covering stages of life corresponding to neonatal, childhood and adolescence periods in humans. This animal model will be useful to explore the mechanisms involved in CS-induced carcinogenesis and to investigate the protective effects of dietary agents and chemopreventive drugs. JF - Carcinogenesis AU - Balansky, Roumen AU - Ganchev, Gancho AU - Iltcheva, Marietta AU - Steele, Vernon E AU - D'Agostini, Francesco AU - De Flora, Silvio AD - Department of Health Sciences, University of Genoa, Via A. Pastore 1, I-16132 Genoa, Italy. National Center of Oncology, Sofia 1756, Bulgaria. National Cancer Institute, Rockville, MD 20892, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2236 EP - 2243 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 10 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Autopsy KW - Adolescence KW - Animal models KW - Cigarette smoke KW - Carcinogens KW - Tumors KW - Urinary tract KW - Children KW - Alveoli KW - Birth KW - Metastases KW - Hyperplasia KW - Blood vessels KW - Epidemiology KW - Carcinogenesis KW - Liver KW - Benzo(a)pyrene KW - Neonates KW - Drugs KW - Adenoma KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20274674?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Potent+carcinogenicity+of+cigarette+smoke+in+mice+exposed+early+in+life&rft.au=Balansky%2C+Roumen%3BGanchev%2C+Gancho%3BIltcheva%2C+Marietta%3BSteele%2C+Vernon+E%3BD%27Agostini%2C+Francesco%3BDe+Flora%2C+Silvio&rft.aulast=Balansky&rft.aufirst=Roumen&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=2236&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autopsy; Adolescence; Animal models; Cigarette smoke; Urinary tract; Tumors; Carcinogens; Children; Alveoli; Metastases; Birth; Hyperplasia; Epidemiology; Blood vessels; Carcinogenesis; Liver; Benzo(a)pyrene; Neonates; Adenoma; Drugs; Lung cancer ER - TY - JOUR T1 - Prospective investigation of the cigarette smoking-head and neck cancer association by sex AN - 20268440; 7597396 AB - BACKGROUND. Men are approximately 3 times more likely to develop squamous cancers of the head and neck (oral cavity, pharynx, and larynx) than women. Very few prospective studies have examined the association between cigarette smoking and cancers of the head and neck in women, even though the rates of smoking in women are increasing rapidly worldwide. METHODS. The association between cigarette smoking and head and neck cancer was investigated in 476,211 participants, aged 50-71 years, of the National Institutes of Health/American Association of Retired Persons (NIH-AARP) diet and health study by using age-standardized incidence rates and hazard ratios from Cox models adjusted for other risk factors for these cancers. RESULTS. Over the course of follow-up (1995 through 2000), 584 men and 175 women were diagnosed with head and neck cancer. Nonsmoking (24.4), former smoking (36.9), and current smoking (147.3) men had higher rates of incident head and neck cancer per 100,000 person-years of follow-up than women did in each equivalent category of cigarette use (non: 4.8; former: 17.2; current: 75.7). The hazard ratios associated with smoking were significantly larger in women (12.96; 95% confidence interval [CI], 7.81-21.52) than in men (5.45, 95% CI, 4.22-7.05; P for interaction: <.001) for head and neck cancer overall and also for the 3 subsites (oral cavity, oro-hypopharynx, and larynx) examined in stratified analyses. Ever-smoking accounted for 45% of head and neck cancers in men and 75% in women, assuming causality. CONCLUSIONS. Cigarette smoking is a strong risk factor for head and neck cancer in both men and women. Incidence rates of head and neck cancer were higher in male smokers than female smokers, but smoking may explain a higher proportion of head and neck cancer in women than in men. Cancer 2007. Published 2007 by the American Cancer Society. JF - Cancer AU - Freedman, Neal D AU - Abnet, Christian C AU - Leitzmann, Michael F AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute, Rockville, Maryland, abnetc@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1593 EP - 1601 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 110 IS - 7 SN - 0008-543X, 0008-543X KW - Toxicology Abstracts KW - Diets KW - Pharynx KW - Risk factors KW - Cigarette smoking KW - Larynx KW - Head and neck cancer KW - Neck KW - Cancer KW - Oral cavity KW - Models KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20268440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Prospective+investigation+of+the+cigarette+smoking-head+and+neck+cancer+association+by+sex&rft.au=Freedman%2C+Neal+D%3BAbnet%2C+Christian+C%3BLeitzmann%2C+Michael+F%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Freedman&rft.aufirst=Neal&rft.date=2007-10-01&rft.volume=110&rft.issue=7&rft.spage=1593&rft.isbn=&rft.btitle=&rft.title=Cancer&rft.issn=0008543X&rft_id=info:doi/10.1002%2Fcncr.22930 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Pharynx; Risk factors; Cigarette smoking; Larynx; Head and neck cancer; Neck; Oral cavity; Cancer; Models DO - http://dx.doi.org/10.1002/cncr.22930 ER - TY - JOUR T1 - Ambient Ozone Primes Pulmonary Innate Immunity in Mice AN - 20202848; 7614943 AB - Exposure to ozone in air pollution in urban environments is associated with increases in pulmonary-related hospitalizations and mortality. Because ozone also alters clearance of pulmonary bacterial pathogens, we hypothesized that inhalation of ozone modifies innate immunity in the lung. To address our hypothesis, we exposed C57BL/6J mice to either free air or ozone, and then subsequently challenged with an aerosol of Escherichia coli LPS. Pre-exposure to ozone resulted in enhanced airway hyperreactivity, higher concentrations of both total protein and proinflammatory cytokines in lung lavage fluid, enhanced LPS-mediated signaling in lung tissue, and higher concentrations of serum IL-6 following inhalation of LPS. However, pre-exposure to ozone dramatically reduced inflammatory cell accumulation to the lower airways in response to inhaled LPS. The reduced concentration of cells in the lower airways was associated with enhanced apoptosis of both lung macrophages and systemic circulating monocytes. Moreover, both flow cytometry and confocal microscopy indicate that inhaled ozone causes altered distribution of TLR4 on alveolar macrophages and enhanced functional response to endotoxin by macrophages. These observations indicate that ozone exposure increases both the pulmonary and the systemic biologic response to inhaled LPS by priming the innate immune system. JF - Journal of Immunology AU - Hollingsworth, John W AU - Maruoka, Shuichiro AU - Li, Zhuowei AU - Potts, Erin N AU - Brass, David M AU - Garantziotis, Stavros AU - Fong, Alan AU - Foster, WMichael AU - Schwartz, David A AD - Duke University Medical Center, Durham, NC 27710. National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709. University of North Carolina, Chapel Hill, NC 27599 Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 4367 EP - 4375 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 7 SN - 0022-1767, 0022-1767 KW - Pollution Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Endotoxins KW - Macrophages KW - Interleukin 6 KW - Inhalation KW - Apoptosis KW - immune system KW - Immune system KW - Flow cytometry KW - Escherichia coli KW - Lipopolysaccharides KW - Monocytes KW - TLR4 protein KW - Urban environments KW - Respiratory tract KW - Ozone KW - Mortality KW - Aerosols KW - Immunology KW - Mice KW - Immunity KW - Pathogens KW - Alveoli KW - Inflammation KW - Air pollution KW - hypersensitivity KW - Lung KW - Microscopy KW - Confocal microscopy KW - Proteins KW - Toll-like receptors KW - Signal transduction KW - P 0000:AIR POLLUTION KW - F 06955:Immunomodulation & Immunopharmacology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20202848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Ambient+Ozone+Primes+Pulmonary+Innate+Immunity+in+Mice&rft.au=Hollingsworth%2C+John+W%3BMaruoka%2C+Shuichiro%3BLi%2C+Zhuowei%3BPotts%2C+Erin+N%3BBrass%2C+David+M%3BGarantziotis%2C+Stavros%3BFong%2C+Alan%3BFoster%2C+WMichael%3BSchwartz%2C+David+A&rft.aulast=Hollingsworth&rft.aufirst=John&rft.date=2007-10-01&rft.volume=179&rft.issue=7&rft.spage=4367&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Interleukin 6; Macrophages; Endotoxins; Mortality; Aerosols; Apoptosis; Immune system; Pathogens; Immunity; Alveoli; Inflammation; Flow cytometry; Air pollution; Lung; Confocal microscopy; Lipopolysaccharides; Monocytes; TLR4 protein; Toll-like receptors; Signal transduction; Ozone; Respiratory tract; Urban environments; immune system; Immunology; Mice; hypersensitivity; Microscopy; Proteins; Escherichia coli ER - TY - JOUR T1 - Prevalence and quantitation of parvovirus B19 DNA levels in blood donors with a sensitive polymerase chain reaction screening assay AN - 20171173; 8008434 AB - BACKGROUND: Blood donor parvovirus B19 DNA prevalence with sensitive nucleic acid test assays has recently been demonstrated to be higher than that found with assays designed to detect high viral titers in the plasma manufacturing sector. STUDY DESIGN AND METHODS: Stored plasma aliquots from 5020 donations collected between 2000 and 2003 at seven US blood centers were tested. Testing was performed with a real-time B19 DNA polymerase chain reaction (PCR; TaqMan, Applied Biosystems) assay with a 50 percent limit of detection (LOD) of 1.6 IU per mL (95% confidence interval [lsqb]CI[rsqb], 1.2-2.1 IU-mL) and a 95 percent LOD of 16.5 IU per mL (95% CI, 10.6-33.9 IU-mL). Confirmation and quantitation of B19 DNA was accomplished by retesting of two additional subaliquots. Confirmed-positive specimens were tested for the presence of anti-B19 immunoglobulin M (IgM) and IgG with FDA-licensed assays. RESULTS: B19 DNA prevalence was 0.88 percent (95% CI, 0.64%-1.2%). Among the 23 donations with B19 DNA titers of at least 20 IU per mL, the median DNA concentration was 105 IU per mL with an interquartile range of 42 to 481 IU per mL; the highest value was 1869 IU per mL. All B19 DNA-positive donations were positive for the presence of IgG and 10 (23%) were also positive for the presence of IgM; IgM seropositivity was associated with increasing DNA levels (p = 0.0013). CONCLUSION: Low-level B19 DNA was detected in nearly 1 percent of donations. The 23 percent of DNA-positive donations with both IgM and IgG B19 antibody most likely represent acute resolving infection, whereas those with IgG but no IgM are most consistent with a more chronic and possibly persistent phase of B19 infection. JF - Transfusion AU - Kleinman, Steven H AU - Glynn, Simone A AU - Lee, Tzong-Hae AU - Tobler, Leslie AU - Montalvo, Leilani AU - Todd, Deborah AU - Kiss, Joseph E AU - Shyamala, Venkatakrishna AU - Busch, Michael P AD - From Westat, Rockville, Maryland; Blood Systems Research Institute, San Francisco, California; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Chiron Corp., Emeryville, California; Digene Corp., Gaithersburg, Maryland; and the National Heart, Lung, and Blood Institute, Bethesda, Maryland., GeorgeSchreiber@westat.com Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1756 EP - 1764 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 47 IS - 10 SN - 0041-1132, 0041-1132 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts KW - Blood donors KW - Viruses KW - Assays KW - Parvovirus B19 KW - nucleic acids KW - DNA-directed DNA polymerase KW - blood donors KW - Chronic infection KW - DNA KW - infection KW - Immunoglobulin G KW - Polymerase chain reaction KW - Quantitation KW - Nucleic acids KW - Immunoglobulin M KW - H 13000:Medical Safety KW - V 22320:Replication KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20171173?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transfusion&rft.atitle=Prevalence+and+quantitation+of+parvovirus+B19+DNA+levels+in+blood+donors+with+a+sensitive+polymerase+chain+reaction+screening+assay&rft.au=Kleinman%2C+Steven+H%3BGlynn%2C+Simone+A%3BLee%2C+Tzong-Hae%3BTobler%2C+Leslie%3BMontalvo%2C+Leilani%3BTodd%2C+Deborah%3BKiss%2C+Joseph+E%3BShyamala%2C+Venkatakrishna%3BBusch%2C+Michael+P&rft.aulast=Kleinman&rft.aufirst=Steven&rft.date=2007-10-01&rft.volume=47&rft.issue=10&rft.spage=1756&rft.isbn=&rft.btitle=&rft.title=Transfusion&rft.issn=00411132&rft_id=info:doi/10.1111%2Fj.1537-2995.2007.01341.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Blood donors; nucleic acids; DNA-directed DNA polymerase; Chronic infection; Immunoglobulin G; Polymerase chain reaction; Quantitation; Immunoglobulin M; blood donors; Viruses; infection; DNA; Assays; Nucleic acids; Parvovirus B19 DO - http://dx.doi.org/10.1111/j.1537-2995.2007.01341.x ER - TY - JOUR T1 - A Comparison and Critical Analysis of Preclinical Anticancer Vaccination Strategies AN - 20120463; 7617072 AB - Anticancer vaccines have been extensively studied in animal models and in clinical trials. While vaccination can lead to tumor protection in numerous murine models, objective tumor regressions after anticancer vaccination in clinical trials have been rare. B16 is a poorly immunogenic murine melanoma that has been extensively used in anticancer vaccination experiments. Because B16 has been widely used, different vaccination strategies can be compared. We reviewed the results obtained when B16 was treated with five common vaccine types: recombinant viral vaccines, DNA vaccines, dendritic cell vaccines, whole-tumor vaccines, and peptide vaccines. We also reviewed the results obtained when B16 was treated with vaccines combined with adoptive transfer of tumor antigen-specific T cells. We found several characteristics of vaccination regimens that were associated with antitumor efficacy. Many vaccines that incorporated xenogeneic antigens exhibited more potent anticancer activity than vaccines that were identical except that they incorporated the syngeneic version of the same antigen. Interleukin-2 enhanced the antitumor efficacy of several vaccines. Finally, several effective regimens generated large numbers of tumor antigen-specific CD8 super(+) T cells. Identification of vaccine characteristics that are associated with antitumor efficacy may aid in the development of more effective anticancer vaccination strategies. JF - Experimental Biology and Medicine AU - Kochenderfer, J N AU - Gress, R E AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1130 EP - 1141 PB - Society for Experimental Biology and Medicine, 195 W. Spring Valley Avenue Maywood NJ 07607-1727 USA, [mailto:sebm@inch.com], [URL:http://www.sebm.org/] VL - 232 IS - 9 SN - 1535-3699, 1535-3699 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Interleukin 2 KW - Animal models KW - CD8 antigen KW - Tumors KW - Clinical trials KW - Melanoma KW - Dendritic cells KW - DNA vaccines KW - Combined vaccines KW - Immunogenicity KW - Reviews KW - Adoptive transfer KW - Lymphocytes T KW - Antitumor activity KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - F 06920:Transplantation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20120463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+Biology+and+Medicine&rft.atitle=A+Comparison+and+Critical+Analysis+of+Preclinical+Anticancer+Vaccination+Strategies&rft.au=Kochenderfer%2C+J+N%3BGress%2C+R+E&rft.aulast=Kochenderfer&rft.aufirst=J&rft.date=2007-10-01&rft.volume=232&rft.issue=9&rft.spage=1130&rft.isbn=&rft.btitle=&rft.title=Experimental+Biology+and+Medicine&rft.issn=15353699&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 2; Animal models; Tumors; CD8 antigen; Clinical trials; Melanoma; Dendritic cells; DNA vaccines; Immunogenicity; Combined vaccines; Reviews; Lymphocytes T; Adoptive transfer; Antitumor activity ER - TY - JOUR T1 - New lane in the information highway: alternative reading frame peptides elicit T cells with potent antiretrovirus activity AN - 20101695; 7742908 AB - CD8 super(+) T cells rapidly recognize virus-infected cells due to the generation of antigenic peptides from defective ribosomal products (DRiPs) that are encoded by standard open reading frames (ORFs). New data now show that alternative reading frame (ARF) DRiPs can also induce robust CD8 super(+) T cell responses. ARF-specific T cells control retroviral replication and select for viral escape in monkeys, providing the most compelling evidence to date for the biological relevance of ARF immunosurveillance. JF - Journal of Experimental Medicine AU - Yewdell, Jonathan W AU - Hickman, Heather D AD - J.W. Yewdell and H.D. Hickman are at Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2501 EP - 2504 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 11 SN - 0022-1007, 0022-1007 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Data processing KW - Replication KW - Immunosurveillance KW - Lymphocytes T KW - Language KW - CD8 antigen KW - Open reading frames KW - V 22350:Immunology KW - W 30940:Products KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20101695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=New+lane+in+the+information+highway%3A+alternative+reading+frame+peptides+elicit+T+cells+with+potent+antiretrovirus+activity&rft.au=Yewdell%2C+Jonathan+W%3BHickman%2C+Heather+D&rft.aulast=Yewdell&rft.aufirst=Jonathan&rft.date=2007-10-01&rft.volume=204&rft.issue=11&rft.spage=2501&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Immunosurveillance; Replication; Lymphocytes T; Language; CD8 antigen; Open reading frames ER - TY - JOUR T1 - Insights into the mechanisms of quinol oxidation in cytochrome bc sub(1) in light of the structure of the bacterial complex AN - 20057152; 8322593 AB - The ten years since the first publication of the structure from bovine heart mitochondria in 1997 have significantly broadened our structural knowledge of cytochrome bc sub(1) and b sub(6)f complexes from various organisms under a variety of conditions providing unprecedented mechanistic insights into the function of these essential enzymes. Still many questions remain. The bifurcated electron transfer at the quinol oxidation (Qp) site is one of the most difficult and unresolved problems. Intertwined with it, the proton translocation pathway and the quinol oxidation chemistry have remained focuses of intense research. Structural studies of mitochondrial bc sub(1) complexes have not only provided an atomic view of the bc sub(1) complex, defining many critical, functionally important features such as the locations of the Qp and Qn sites, but have also offered a number of important clues to mechanistic issues leading to the formulation of the "conformational switch of ISP hypothesis. Intensive biochemical, genetic, and biophysical studies coupled with structural investigations have provided strong support for this hypothesis. The recent structure determination of the bc sub(1) from the photosynthetic bacterium R. sphaeroides promises further insight. JF - Biophysical Reviews and Letters AU - Esser, L AU - Yu, L AU - Yu, C-A AU - Xia, D AD - Laboratory of Cell Biology, Center for Cancer Research National Cancer Institute, National Institutes of Health Bethesda, Maryland 20892, USA, dixia@helix.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 229 EP - 257 VL - 2 IS - 3-4 SN - 1793-0480, 1793-0480 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Heart KW - Bacteria KW - Cytochrome bc1 KW - quinol KW - Protons KW - Oxidation KW - Mitochondria KW - Enzymes KW - Electron transfer KW - Translocation KW - A 01490:Miscellaneous KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20057152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+Reviews+and+Letters&rft.atitle=Insights+into+the+mechanisms+of+quinol+oxidation+in+cytochrome+bc+sub%281%29+in+light+of+the+structure+of+the+bacterial+complex&rft.au=Esser%2C+L%3BYu%2C+L%3BYu%2C+C-A%3BXia%2C+D&rft.aulast=Esser&rft.aufirst=L&rft.date=2007-10-01&rft.volume=2&rft.issue=3-4&rft.spage=229&rft.isbn=&rft.btitle=&rft.title=Biophysical+Reviews+and+Letters&rft.issn=17930480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Heart; Cytochrome bc1; quinol; Protons; Oxidation; Enzymes; Mitochondria; Electron transfer; Translocation; Bacteria ER - TY - JOUR T1 - No Evidence of Clonal Dominance in Primates up to 4 Years Following Transplantation of Multidrug Resistance 1 Retrovirally Transduced Long-Term Repopulating Cells AN - 20027714; 7617370 AB - Previous murine studies have suggested that retroviral multidrug resistance 1 (MDR1) gene transfer may be associated with a myeloproliferative disorder. Analyses at a clonal level and prolonged long-term follow-up in a model with more direct relevance to human biology were lacking. In this study, we analyzed the contribution of individual CD34-selected peripheral blood progenitor cells to long-term rhesus macaque hematopoiesis after transduction with a retroviral vector either expressing the multidrug resistance 1 gene (HaMDR1 vector) or expressing the neomycin resistance (NeoR) gene (G1Na vector). We found a total of 122 contributing clones from 8 weeks up to 4 years after transplantation. One hundred two clones contained the G1Na vector, whereas only 20 clones contained the HaMDR1 vector. Here, we show for the first time real-time polymerase chain reaction based quantification of individual transduced cell clones constituting 0.0008% plus or minus 0.0003% to 0.0041% plus or minus 0.00032% of primate peripheral blood cells. No clonal dominance was observed. Disclosure of potential conflicts of interest is found at the end of this article. JF - Stem Cells AU - Bozorgmehr, Farastuk AU - Laufs, Stefanie AU - Sellers, Stephanie E AU - Roeder, Ingo AU - Zeller, Werner J AU - Dunbar, Cynthia E AU - Fruehauf, Stefan AD - Research Group Pharmacology of Cancer Treatment, German Cancer Research Center, Heidelberg, Germany. Department of Experimental Surgery Mannheim Faculty, University of Heidelberg, and Molecular Oncology of Solid Tumors Unit, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland, USA. Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. Center for Tumor Diagnostics and Therapy, Paracelsus Klinik, Osnabrueck, Germany Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2610 EP - 2618 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 25 IS - 10 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Animal models KW - Peripheral blood KW - Primates KW - Dominance KW - Human biology KW - P-Glycoprotein KW - Stem cells KW - Gene transfer KW - Polymerase chain reaction KW - Hemopoiesis KW - Macaca mulatta KW - Myeloproliferative diseases KW - Multidrug resistance KW - Neomycin KW - NeoR gene KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20027714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=No+Evidence+of+Clonal+Dominance+in+Primates+up+to+4+Years+Following+Transplantation+of+Multidrug+Resistance+1+Retrovirally+Transduced+Long-Term+Repopulating+Cells&rft.au=Bozorgmehr%2C+Farastuk%3BLaufs%2C+Stefanie%3BSellers%2C+Stephanie+E%3BRoeder%2C+Ingo%3BZeller%2C+Werner+J%3BDunbar%2C+Cynthia+E%3BFruehauf%2C+Stefan&rft.aulast=Bozorgmehr&rft.aufirst=Farastuk&rft.date=2007-10-01&rft.volume=25&rft.issue=10&rft.spage=2610&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Animal models; Peripheral blood; Dominance; Human biology; Stem cells; P-Glycoprotein; Gene transfer; Hemopoiesis; Polymerase chain reaction; Multidrug resistance; Myeloproliferative diseases; NeoR gene; Neomycin; Macaca mulatta; Primates ER - TY - JOUR T1 - Are bacterial 'autotransporters' really transporters? AN - 20005335; 8243334 AB - Autotransporters are bacterial outer membrane proteins that consist of a large N-terminal extracellular domain ('passenger domain') and a C-terminal beta -barrel domain (' beta domain'). The beta domain was originally proposed to function as a channel that transports its own passenger domain across the outer membrane. Results of recent structural, biochemical and molecular genetic studies, however, have challenged this idea. Here I describe an alternative model in which translocation of the passenger domain is mediated by an exogenous factor (possibly a newly identified factor necessary for assembly of outer membrane proteins called 'Omp85/YaeT'), whereas the beta domain only targets the protein to the outer membrane and serves as a membrane anchor. JF - Trends in Microbiology AU - Bernstein, H D Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 441 EP - 447 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 15 IS - 10 SN - 0966-842X, 0966-842X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Protein transport KW - outer membrane proteins KW - Reviews KW - Models KW - J 02330:Biochemistry KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20005335?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Microbiology&rft.atitle=Are+bacterial+%27autotransporters%27+really+transporters%3F&rft.au=Bernstein%2C+H+D&rft.aulast=Bernstein&rft.aufirst=H&rft.date=2007-10-01&rft.volume=15&rft.issue=10&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Trends+in+Microbiology&rft.issn=0966842X&rft_id=info:doi/10.1016%2Fj.tim.2007.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein transport; outer membrane proteins; Reviews; Models; Bacteria DO - http://dx.doi.org/10.1016/j.tim.2007.09.007 ER - TY - JOUR T1 - Optimization of the Dosage of Flucytosine in Combination with Amphotericin B for Disseminated Candidiasis: a Pharmacodynamic Rationale for Reduced Dosing AN - 19982317; 7608081 AB - Amphotericin B and flucytosine (5FC) have an additive effect when used for disseminated candidiasis. Here, we bridge the results of an experimental pharmacodynamic study to humans and demonstrate that a 5FC dosage of 25 mg/kg of body weight/day in four divided doses in combination with amphotericin B produces near-maximal effect. JF - Antimicrobial Agents & Chemotherapy AU - Hope, William W AU - Warn, Peter A AU - Sharp, Andrew AU - Reed, Paul AU - Keevil, Brian AU - Louie, Arnold AU - Walsh, Thomas J AU - Denning, David W AU - Drusano, George L AD - Department of Medicine, The University of Manchester, 1.800 Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom. Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208. Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Department of Biochemistry, Hope Hospital, Salford, Manchester M6 8HD, United Kingdom. Department of Biochemistry, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, United Kingdom Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 3760 EP - 3762 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Amphotericin B KW - Candidiasis KW - Body weight KW - flucytosine KW - Pharmacodynamics KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19982317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Optimization+of+the+Dosage+of+Flucytosine+in+Combination+with+Amphotericin+B+for+Disseminated+Candidiasis%3A+a+Pharmacodynamic+Rationale+for+Reduced+Dosing&rft.au=Hope%2C+William+W%3BWarn%2C+Peter+A%3BSharp%2C+Andrew%3BReed%2C+Paul%3BKeevil%2C+Brian%3BLouie%2C+Arnold%3BWalsh%2C+Thomas+J%3BDenning%2C+David+W%3BDrusano%2C+George+L&rft.aulast=Hope&rft.aufirst=William&rft.date=2007-10-01&rft.volume=51&rft.issue=10&rft.spage=3760&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Body weight; Candidiasis; Pharmacodynamics; flucytosine ER - TY - JOUR T1 - Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents AN - 19975196; 7608045 AB - Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations of ZDV and 3TC during chronic therapy on a QD regimen. Human immunodeficiency virus-infected patients (12 to 24 years) taking ZDV (600 mg/day) and 3TC (300 mg/day) as part of a highly active antiretroviral therapy regimen received QD and BID regimens of ZDV and 3TC for 7 to 14 days in a crossover design. Serial blood samples were obtained over 24 h on the QD regimen. Intracellular mono-, di-, and triphosphates for ZDV and 3TC were measured. The median ratio of BID/QD for ZDV-TP predose concentrations was 1.28 (95% confidence interval [CI] = 1.00 to 2.45) and for 3TC-TP was 1.12 (95% CI = 0.81 to 1.96). The typical population estimated half-lives ( plus or minus the standard error of the mean) were 9.1 plus or minus 0.859 h for ZDV-TP and 17.7 plus or minus 2.8 h for 3TC-TP. Most patients had detectable levels of the TP of ZDV (24 of 27) and 3TC (24 of 25) 24 h after dosing, and half-lives on a QD regimen were similar to previously reported values when the drugs were given BID. Lower, but not significantly different, concentrations of ZDV-TP were demonstrated in the QD regimen compared to the BID regimen (P = 0.056). Although findings were similar between the BID and QD groups, the lower concentrations of ZDV and the number of patients below the level of detection after 24 h suggests that ZDV should continue to be administered BID. JF - Antimicrobial Agents & Chemotherapy AU - Flynn, Patricia M AU - Rodman, John AU - Lindsey, Jane C AU - Robbins, Brian AU - Capparelli, Edmund AU - Knapp, Katherine M AU - Rodriguez, Jose F AU - McNamara, James AU - Serchuck, Leslie AU - Heckman, Barbara AU - Martinez, Jaime AD - Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee. Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee. Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee. Statistical & Data Analysis Center, Harvard School of Public Health, Boston, Massachusetts. Pediatric Pharmacology Research Unit, University of California, San Diego, California. Department of Biochemistry, University of Puerto Rico, San Juan, Puerto Rico. Puerto Rico Forensic Sciences Institute, San Juan, Puerto Rico. National Institute of Allergy and Infectious Diseases. National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland. Frontier Science & Technology Research Foundation, Amherst, New York. Department of Pediatrics, Stroger Hospital of Cook County/CORE Center, Chicago, Illinois Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 3516 EP - 3522 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Antiviral agents KW - highly active antiretroviral therapy KW - Adolescence KW - Immunodeficiency KW - BID protein KW - Lamivudine KW - Zidovudine KW - Metabolites KW - Antiviral activity KW - Metabolism KW - Pharmacokinetics KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Intracellular+Pharmacokinetics+of+Once+versus+Twice+Daily+Zidovudine+and+Lamivudine+in+Adolescents&rft.au=Flynn%2C+Patricia+M%3BRodman%2C+John%3BLindsey%2C+Jane+C%3BRobbins%2C+Brian%3BCapparelli%2C+Edmund%3BKnapp%2C+Katherine+M%3BRodriguez%2C+Jose+F%3BMcNamara%2C+James%3BSerchuck%2C+Leslie%3BHeckman%2C+Barbara%3BMartinez%2C+Jaime&rft.aulast=Flynn&rft.aufirst=Patricia&rft.date=2007-10-01&rft.volume=51&rft.issue=10&rft.spage=3516&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antiviral agents; highly active antiretroviral therapy; Adolescence; Immunodeficiency; Zidovudine; Lamivudine; BID protein; Metabolites; Antiviral activity; Pharmacokinetics; Metabolism ER - TY - JOUR T1 - Prion Protein Expression Differences in Microglia and Astroglia Influence Scrapie-Induced Neurodegeneration in the Retina and Brain of Transgenic Mice AN - 19884783; 7615727 AB - Activated microglia and astroglia are known to be involved in a variety of neurodegenerative diseases, including prion diseases. In the present experiments, we studied activation of astroglia and microglia after intraocular scrapie infection in transgenic mice expressing prion protein (PrP) in multiple cell types (tg7 mice) or in neurons only (tgNSE mice). In this model, scrapie infection and protease-resistant PrP deposition occurs in the retinas of both strains of mice, but retinal degeneration is observed only in tg7 mice. Our results showed that the retinas of tg7 and tgNSE mice both had astroglial activation with increased chemokine expression during the course of infection. However, only tg7 retinas exhibited strong microglial activation compared to tgNSE retinas, which showed little microglial activation by biochemical or morphological criteria. Therefore, microglial PrP expression might be required for scrapie-induced retinal microglial activation and damage. Furthermore, microglial activation preceded retinal neurodegeneration in tg7 mice, suggesting that activated microglia might contribute to the degenerative process, rather than being a response to the damage. Surprisingly, brain differed from retina in that an altered profile of microglial activation markers was upregulated, and the profiles in the two mouse strains were indistinguishable. Microglial activation in the brain was associated with severe brain vacuolation and neurodegeneration, leading to death. Thus, retinal and brain microglia appeared to differ in their requirements for activation, suggesting that different activation pathways occur in the two tissues. JF - Journal of Virology AU - Kercher, Lisa AU - Favara, Cynthia AU - Striebel, James F AU - LaCasse, Rachel AU - Chesebro, Bruce AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 10340 EP - 10351 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 19 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Chemokines KW - Brain injury KW - retinal degeneration KW - Astrocytes KW - Retina KW - Animal models KW - Brain KW - Scrapie KW - Transgenic mice KW - Infection KW - Microglia KW - Neurodegenerative diseases KW - Prion protein KW - W 30925:Genetic Engineering KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19884783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Prion+Protein+Expression+Differences+in+Microglia+and+Astroglia+Influence+Scrapie-Induced+Neurodegeneration+in+the+Retina+and+Brain+of+Transgenic+Mice&rft.au=Kercher%2C+Lisa%3BFavara%2C+Cynthia%3BStriebel%2C+James+F%3BLaCasse%2C+Rachel%3BChesebro%2C+Bruce&rft.aulast=Kercher&rft.aufirst=Lisa&rft.date=2007-10-01&rft.volume=81&rft.issue=19&rft.spage=10340&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chemokines; Brain injury; Retina; Astrocytes; retinal degeneration; Brain; Animal models; Scrapie; Microglia; Infection; Transgenic mice; Neurodegenerative diseases; Prion protein ER - TY - JOUR T1 - Adjunctive Passive Immunotherapy in Human Immunodeficiency Virus Type 1-Infected Individuals Treated with Antiviral Therapy during Acute and Early Infection AN - 19883467; 7615794 AB - Three neutralizing monoclonal antibodies (MAbs), 2G12, 2F5, and 4E10, with activity in vitro and in vivo were administered in an open-label, nonrandomized, proof-of-concept study to attempt to prevent viral rebound after interruption of antiretroviral therapy (ART). Ten human immunodeficiency virus type 1-infected individuals identified and treated with ART during acute and early infection were enrolled. The first six patients were administered 1.0 g of each of the three MAbs per infusion. The remaining four patients received 2G12 at 1.0 g/infusion and 2.0 g/infusion of 2F5 and 4E10. The MAbs were well tolerated. Grade I post-partial thromboplastin time prolongations were noted. Viral rebound was observed in 8/10 subjects (28 to 73 days post-ART interruption), and 2/10 subjects remained aviremic over the course of the study. In seven of eight subjects with viral rebound, clear resistance to 2G12 emerged, whereas reductions in the susceptibilities of plasma-derived recombinant viruses to 2F5 and 4E10 were neither sustained nor consistently measured. Viral rebound was associated with a preferential depletion of CD4 super(+) T cells within the gastrointestinal tract. Though safe, the use of MAbs generally delayed, but did not prevent, virologic rebound. Consideration should be given to further pilot studies with alternative combinations of MAbs and perhaps additional novel treatment modalities. JF - Journal of Virology AU - Mehandru, Saurabh AU - Vcelar, Brigitta AU - Wrin, Terri AU - Stiegler, Gabriela AU - Joos, Beda AU - Mohri, Hiroshi AU - Boden, Daniel AU - Galovich, Justin AU - Tenner-Racz, Klara AU - Racz, Paul AU - Carrington, Mary AU - Petropoulos, Christos AU - Katinger, Hermann AU - Markowitz, Martin AD - Aaron Diamond AIDS Research Center, The Rockefeller University. 455 First Avenue, New York, New York 10016. Polymun Scientific, Nussdorfer Laende 11, A-1190 Vienna, Austria. Monogram Biosciences Inc., 345 Oyster Point Boulevard, South San Francisco, California. Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zuerich, Switzerland. Bernhard-Nocht Institut fur Tropenmedizin, 20359 Hamburg, Germany. Laboratory of Genomic Diversity, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702. Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences, Vienna, Austria Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 11016 EP - 11031 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 20 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - CD4 antigen KW - Human immunodeficiency virus KW - Monoclonal antibodies KW - Immunotherapy KW - antiretroviral therapy KW - Lymphocytes T KW - Gastrointestinal tract KW - Infection KW - thromboplastin KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19883467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Adjunctive+Passive+Immunotherapy+in+Human+Immunodeficiency+Virus+Type+1-Infected+Individuals+Treated+with+Antiviral+Therapy+during+Acute+and+Early+Infection&rft.au=Mehandru%2C+Saurabh%3BVcelar%2C+Brigitta%3BWrin%2C+Terri%3BStiegler%2C+Gabriela%3BJoos%2C+Beda%3BMohri%2C+Hiroshi%3BBoden%2C+Daniel%3BGalovich%2C+Justin%3BTenner-Racz%2C+Klara%3BRacz%2C+Paul%3BCarrington%2C+Mary%3BPetropoulos%2C+Christos%3BKatinger%2C+Hermann%3BMarkowitz%2C+Martin&rft.aulast=Mehandru&rft.aufirst=Saurabh&rft.date=2007-10-01&rft.volume=81&rft.issue=20&rft.spage=11016&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CD4 antigen; Monoclonal antibodies; Immunotherapy; antiretroviral therapy; Lymphocytes T; Gastrointestinal tract; Infection; thromboplastin; Human immunodeficiency virus ER - TY - JOUR T1 - Purification, Sequencing, and Molecular Identification of a Mammalian PP-InsP sub(5) Kinase That Is Activated When Cells Are Exposed to Hyperosmotic Stress AN - 19883246; 7614284 AB - Mammalian cells utilize multiple signaling mechanisms to protect against the osmotic stress that accompanies plasma membrane ion transport, solute uptake, and turnover of protein and carbohydrates (Schliess, F., and Haussinger, D. (2002) BIOL: Chem. 383, 577-583). Recently, osmotic stress was found to increase synthesis of bisdiphosphoinositol tetrakisphosphate ((PP) sub(2)-InsP sub(4)), a high energy inositol pyrophosphate (Pesesse, X., Choi, K., Zhang, T., and Shears, S. B. (2004) J. Biol. Chem. 279, 43378-43381). Here, we describe the purification from rat brain of a diphosphoinositol pentakisphosphate kinase (PPIP5K) that synthesizes (PP) sub(2)-InsP sub(4). Partial amino acid sequence, obtained by mass spectrometry, matched the sequence of a 160-kDa rat protein containing a putative ATP-grasp kinase domain. BLAST searches uncovered two human isoforms (PPIP5K1 (160 kDa) and PPIP5K2 (138 kDa)). Recombinant human PPIP5K1, expressed in Escherichia coli, was found to phosphorylate diphosphoinositol pentakisphosphate (PP-InsP sub(5)) to (PP) sub(2)-InsP sub(4) (V sub(max) = 8.3 nmol/mg of protein/min; K sub(m) = 0.34 mu M). Overexpression in human embryonic kidney cells of either PPIP5K1 or PPIP5K2 substantially increased levels of (PP) sub(2)-InsP sub(4), whereas overexpression of a catalytically dead PPIP5K1 super(D332A) mutant had no effect. PPIP5K1 and PPIP5K2 were more active against PP-InsP sub(5) than InsP sub(6), both in vitro and in vivo. Analysis by confocal immunofluorescence showed PPIP5K1 to be distributed throughout the cytoplasm but excluded from the nucleus. Immunopurification of overexpressed PPIP5K1 from osmotically stressed HEK cells (0.2 M sorbitol; 30 min) revealed a persistent, 3.9 plus or minus 0.4-fold activation when compared with control cells. PPIP5Ks are likely to be important signaling enzymes. JF - Journal of Biological Chemistry AU - Choi, Jae H AU - Williams, Jason AU - Cho, Jaiesoon AU - Falck, J R AU - Shears, Stephen B AD - Inositide Signaling Group Laboratory of Signal Transduction and the Protein Microcharacterization Core Facility, Laboratory of Structural Biology, NIEHS, National Institutes of Health, DHHS, Research Triangle Park, North Carolina 27709 and the Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9038 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 30763 EP - 30775 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 42 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Inositol KW - Brain KW - Enzymes KW - Sorbitol KW - Immunofluorescence KW - Mass spectroscopy KW - Osmotic stress KW - Solutes KW - Mammalian cells KW - Plasma membranes KW - Cytoplasm KW - Energy KW - Escherichia coli KW - Protein turnover KW - Carbohydrates KW - pyrophosphates KW - Amino acid sequence KW - Signal transduction KW - J 02410:Animal Diseases KW - N 14815:Nucleotide Sequence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19883246?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Purification%2C+Sequencing%2C+and+Molecular+Identification+of+a+Mammalian+PP-InsP+sub%285%29+Kinase+That+Is+Activated+When+Cells+Are+Exposed+to+Hyperosmotic+Stress&rft.au=Choi%2C+Jae+H%3BWilliams%2C+Jason%3BCho%2C+Jaiesoon%3BFalck%2C+J+R%3BShears%2C+Stephen+B&rft.aulast=Choi&rft.aufirst=Jae&rft.date=2007-10-01&rft.volume=282&rft.issue=42&rft.spage=30763&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Inositol; Brain; Enzymes; Sorbitol; Immunofluorescence; Mass spectroscopy; Osmotic stress; Solutes; Plasma membranes; Mammalian cells; Energy; Cytoplasm; Protein turnover; Carbohydrates; pyrophosphates; Signal transduction; Amino acid sequence; Escherichia coli ER - TY - JOUR T1 - 4-1BB Is Superior to CD28 Costimulation for Generating CD8 super(+) Cytotoxic Lymphocytes for Adoptive Immunotherapy AN - 19880945; 7615003 AB - Artificial APCs (aAPCs) genetically modified to express selective costimulatory molecules provide a reproducible, cost-effective, and convenient method for polyclonal and Ag-specific expansion of human T cells for adoptive immunotherapy. Among the variety of aAPCs that have been studied, acellular beads expressing anti-CD3/anti-CD28 efficiently expand CD4 super(+) cells, but not CD8 super(+) T cells. Cell-based aAPCs can effectively expand cytolytic CD8 super(+) cells, but optimal costimulatory signals have not been defined. 4-1BB, a costimulatory molecule expressed by a minority of resting CD8 super(+) T cells, is transiently up-regulated by all CD8 super(+) T cells following activation. We compared expansion of human cytolytic CD8 super(+) T cells using cell-based aAPCs providing costimulation via 4-1BB vs CD28. Whereas anti-CD3/anti-CD28 aAPCs mostly expand naive cells, anti-CD3/4-1BBL aAPCs preferentially expand memory cells, resulting in superior enrichment of Ag-reactive T cells which recognize previously primed Ags and efficient expansion of electronically sorted CD8 super(+) populations reactive toward viral or self-Ags. Using HLA-A2-Fc fusion proteins linked to 4-1BBL aAPCs, 3-log expansion of Ag-specific CD8 super(+) CTL was induced over 14 days, whereas similar Ag-specific CD8 super(+) T cell expansion did not occur using HLA-A2-Fc/anti-CD28 aAPCs. Furthermore, when compared with cytolytic T cells expanded using CD28 costimulation, CTL expanded using 4-1BB costimulation mediate enhanced cytolytic capacity due, in part, to NKG2D up-regulation. These results demonstrate that 4-1BB costimulation is essential for expanding memory CD8 super(+) T cells ex vivo and is superior to CD28 costimulation for generating Ag-specific products for adoptive cell therapy. JF - Journal of Immunology AU - Zhang, Hua AU - Snyder, Kristen M AU - Suhoski, Megan M AU - Maus, Marcela V AU - Kapoor, Veena AU - June, Carl H AU - Mackall, Crystal L AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, MD 20892. Experimental Transplantation and Immunology Branch, National Cancer Institute, Bethesda, MD 20892. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104 Y1 - 2007/10/01/ PY - 2007 DA - 2007 Oct 01 SP - 4910 EP - 4918 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 7 SN - 0022-1767, 0022-1767 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Histocompatibility antigen HLA KW - Immunological memory KW - Memory cells KW - CD28 antigen KW - CD8 antigen KW - Autoantigens KW - Cell activation KW - Costimulator KW - CD4 antigen KW - Cytotoxicity KW - Adoptive immunotherapy KW - Lymphocytes T KW - Fusion protein KW - Antigen-presenting cells KW - W 30925:Genetic Engineering KW - V 22350:Immunology KW - F 06955:Immunomodulation & Immunopharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19880945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=4-1BB+Is+Superior+to+CD28+Costimulation+for+Generating+CD8+super%28%2B%29+Cytotoxic+Lymphocytes+for+Adoptive+Immunotherapy&rft.au=Zhang%2C+Hua%3BSnyder%2C+Kristen+M%3BSuhoski%2C+Megan+M%3BMaus%2C+Marcela+V%3BKapoor%2C+Veena%3BJune%2C+Carl+H%3BMackall%2C+Crystal+L&rft.aulast=Zhang&rft.aufirst=Hua&rft.date=2007-10-01&rft.volume=179&rft.issue=7&rft.spage=4910&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; Memory cells; Immunological memory; CD8 antigen; CD28 antigen; Autoantigens; Cell activation; Costimulator; Cytotoxicity; CD4 antigen; Adoptive immunotherapy; Lymphocytes T; Antigen-presenting cells; Fusion protein ER - TY - JOUR T1 - Typing Plasmodium yoelii microsatellites using a simple and affordable fluorescent labeling method AN - 19878088; 7585924 AB - The rodent malaria parasite Plasmodium yoelii has been an important animal model for studying malaria pathology and host-parasite interactions. Compared with other rodent malaria parasites such as Plasmodium chabaudi, however, genetic mapping studies on P. yoelii have been limited, partly due to the absence of genetic markers and the lack of well characterized phenotypes. Taking advantage of the available genome sequence, we initiated a project to develop a high-resolution microsatellite (MS) map for P. yoelii to study malaria disease phenotypes. Here we report screening the P. yoelii genome for simple sequence repeats and development of an inexpensive method (modified from a previously reported procedure) for typing malaria parasite MS: instead of labeling individual polymerase chain reaction primers, a single fluorescently labeled primer was used to type the MS markers. We evaluated various polymerase chain reaction cycling conditions and M13-tailed/labeled M13 primer ratios to establish a simple and robust procedure for typing P. yoelii MS markers. We also compared typing efficiencies between individually labeled primers and the M13-tailed single labeled primer method and found that the two approaches were comparable. Preliminary analyses of seven P. yoelii isolates deposited at MR4 with 77 MS showed that the markers were highly polymorphic and that the isolates belonged to two groups, suggesting potential common ancestry or laboratory contaminations among the isolates. The MS markers and the typing method provide important tools for genetic studies of P. yoelii. There is a good possibility that this method can be applied to type MS from other malaria parasites including important human pathogens Plasmodium falciparum and Plasmodium vivax. JF - Molecular and Biochemical Parasitology AU - Li, Jian AU - Zhang, Yanhui AU - Sullivan, Margery AU - Hong, Linxian AU - Huang, Lei AU - Lu, Fangli AU - McCutchan, Thomas F AU - Su, Xin-zhuan AD - Laboratory of Parasitology Research, School of Life Science, Xiamen University, Xiamen, Fujian 361005, The People's Republic of China, xsu@niaid.nih.gov Y1 - 2007/10// PY - 2007 DA - October 2007 SP - 94 EP - 102 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 155 IS - 2 SN - 0166-6851, 0166-6851 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Genetic mapping KW - Genotyping KW - Rodent malaria parasite KW - Simple sequence repeat KW - Genomes KW - Parasites KW - Contamination KW - Pathology KW - Nucleotide sequence KW - Animal models KW - Plasmodium vivax KW - Malaria KW - Genotypes KW - Phenotypes KW - Plasmodium chabaudi KW - Simple sequence repeats KW - Polymerase chain reaction KW - Plasmodium yoelii KW - Host-parasite interactions KW - Microsatellites KW - Plasmodium falciparum KW - Pathogens KW - Biopolymorphism KW - Typing KW - Genetic markers KW - DNA KW - Primers KW - Gene mapping KW - K 03300:Methods KW - Q1 08484:Species interactions: parasites and diseases KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19878088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Biochemical+Parasitology&rft.atitle=Typing+Plasmodium+yoelii+microsatellites+using+a+simple+and+affordable+fluorescent+labeling+method&rft.au=Li%2C+Jian%3BZhang%2C+Yanhui%3BSullivan%2C+Margery%3BHong%2C+Linxian%3BHuang%2C+Lei%3BLu%2C+Fangli%3BMcCutchan%2C+Thomas+F%3BSu%2C+Xin-zhuan&rft.aulast=Li&rft.aufirst=Jian&rft.date=2007-10-01&rft.volume=155&rft.issue=2&rft.spage=94&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Biochemical+Parasitology&rft.issn=01666851&rft_id=info:doi/10.1016%2Fj.molbiopara.2007.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Pathology; DNA; Malaria; Genotypes; Biopolymorphism; Phenotypes; Genomes; Contamination; Nucleotide sequence; Microsatellites; Animal models; Pathogens; Typing; Genetic markers; Polymerase chain reaction; Simple sequence repeats; Primers; Host-parasite interactions; Gene mapping; Plasmodium chabaudi; Plasmodium yoelii; Plasmodium vivax; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.molbiopara.2007.06.003 ER - TY - JOUR T1 - CB sub(2)-receptor stimulation attenuates TNF- alpha -induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion AN - 19870320; 7608644 AB - Targeting cannabinoid-2 (CB sub(2)) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms by which CB sub(2) activation exerts its anti-inflammatory effects and the cellular targets are elusive. Here, we investigated the effects of CB sub(2)-receptor activation on TNF- alpha -induced signal transduction in human coronary artery endothelial cells in vitro and on endotoxin-induced vascular inflammatory response in vivo. TNF- alpha induced NF- Kappa B and RhoA activation and upregulation of adhesion molecules ICAM-1 and VCAM-1, increased expression of monocyte chemoattractant protein, enhanced transendothelial migration of monocytes, and augmented monocyte-endothelial adhesion. Remarkably, all of the above-mentioned effects of TNF- alpha were attenuated by CB sub(2) agonists. CB sub(2) agonists also decreased the TNF- alpha - and/or endotoxin-induced ICAM-1 and VCAM-1 expression in isolated aortas and the adhesion of monocytes to aortic vascular endothelium. CB sub(1) and CB sub(2) receptors were detectable in human coronary artery endothelial cells by Western blotting, RT-PCR, real-time PCR, and immunofluorescence staining. Because the above-mentioned TNF- alpha -induced phenotypic changes are critical in the initiation and progression of atherosclerosis and restenosis, our findings suggest that targeting CB sub(2) receptors on endothelial cells may offer a novel approach in the treatment of these pathologies. JF - American Journal of Physiology: Cell Physiology AU - Rajesh, Mohanraj AU - Mukhopadhyay, Partha AU - Batkai, Sandor AU - Hasko, Gyoergy AU - Liaudet, Lucas AU - Huffman, John W AU - Csiszar, Anna AU - Ungvari, Zoltan AU - Mackie, Ken AU - Chatterjee, Subroto AU - Pacher, Pal AD - Section on Oxidative Stress Tissue Injury, Laboratory of Physiological Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - H2210 EP - H2218 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 293 IS - 4 SN - 0363-6143, 0363-6143 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Western blotting KW - Aorta KW - restenosis KW - Arteriosclerosis KW - Immunofluorescence KW - coronary artery KW - Cell activation KW - RhoA protein KW - NF- Kappa B protein KW - Inflammation KW - Leukocyte migration KW - Endothelial cells KW - vascular cell adhesion molecule 1 KW - Inflammatory diseases KW - Cannabinoid CB2 receptors KW - intercellular adhesion molecule 1 KW - Endothelium KW - Chemotactic factors KW - Polymerase chain reaction KW - Tumor necrosis factor- alpha KW - Monocytes KW - Vascular system KW - Signal transduction KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19870320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Cell+Physiology&rft.atitle=CB+sub%282%29-receptor+stimulation+attenuates+TNF-+alpha+-induced+human+endothelial+cell+activation%2C+transendothelial+migration+of+monocytes%2C+and+monocyte-endothelial+adhesion&rft.au=Rajesh%2C+Mohanraj%3BMukhopadhyay%2C+Partha%3BBatkai%2C+Sandor%3BHasko%2C+Gyoergy%3BLiaudet%2C+Lucas%3BHuffman%2C+John+W%3BCsiszar%2C+Anna%3BUngvari%2C+Zoltan%3BMackie%2C+Ken%3BChatterjee%2C+Subroto%3BPacher%2C+Pal&rft.aulast=Rajesh&rft.aufirst=Mohanraj&rft.date=2007-10-01&rft.volume=293&rft.issue=4&rft.spage=H2210&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Cell+Physiology&rft.issn=03636143&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Western blotting; Aorta; restenosis; Immunofluorescence; Arteriosclerosis; Inflammation; NF- Kappa B protein; RhoA protein; Cell activation; coronary artery; Endothelial cells; Leukocyte migration; vascular cell adhesion molecule 1; Inflammatory diseases; Cannabinoid CB2 receptors; Chemotactic factors; Endothelium; intercellular adhesion molecule 1; Polymerase chain reaction; Monocytes; Tumor necrosis factor- alpha; Signal transduction; Vascular system ER - TY - JOUR T1 - Simultaneous GC-EI-MS Determination of D9-Tetrahydrocannabinol, 11-Hydroxy-D9-Tetrahydrocannabinol, and 11-nor-9-Carboxy-D9-Tetrahydrocannabinol in Human Urine Following Tandem Enzyme-Alkaline Hydrolysis AN - 19800407; 8343841 AB - A sensitive and specific method for extraction and quantification of Delta 9-tetrahydrocannabinol (THC), 11-hydroxy- Delta 9-tetrahydrocannabinol (11-OH-THC), and 11-nor-9-carboxy- Delta 9-tetrahydrocannabinol (THCCOOH) in human urine was developed and fully validated. To ensure complete hydrolysis of conjugates and capture of total analyte content, urine samples were hydrolyzed by two methods in series. Initial hydrolysis was with Escherichia coli beta -glucuronidase (Type IX-A) followed by a second hydrolysis utilizing 10N NaOH. Specimens were adjusted to pH 5-6.5, treated with acetonitrile to precipitate protein, and centrifuged, and the supernatants were subjected to solid-phase extraction. Extracted analytes were derivatized with BSTFA and quantified by gas chromatography-mass spectrometry with electron impact ionization. Standard curves were linear from 2.5 to 300 ng/mL. Extraction efficiencies were 57.0-59.3% for THC, 68.3-75.5% for 11-OH-THC, and 71.5-79.7% for THCCOOH. Intra- and interassay precision across the linear range of the assay ranged from 0.1 to 4.3% and 2.6 to 7.4%, respectively. Accuracy was within 15% of target concentrations. This method was applied to the analysis of urine specimens collected from individuals participating in controlled administration cannabis studies, and it may be a useful analytical procedure for determining recency of cannabis use in forensic toxicology applications. JF - Journal of Analytical Toxicology AU - Abraham, T T AU - Lowe, R H AU - Pirnay, SO AU - Darwin, W D AU - Huestis, MA AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 477 EP - 485 VL - 31 IS - 8 SN - 0146-4760, 0146-4760 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Hydrolysis KW - Mass spectroscopy KW - Tetrahydrocannabinol KW - beta -Glucuronidase KW - Urine KW - Gas chromatography KW - Escherichia coli KW - Cannabis KW - Forensic science KW - Acetonitrile KW - Ionization KW - pH effects KW - X 24380:Social Poisons & Drug Abuse KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19800407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Simultaneous+GC-EI-MS+Determination+of+D9-Tetrahydrocannabinol%2C+11-Hydroxy-D9-Tetrahydrocannabinol%2C+and+11-nor-9-Carboxy-D9-Tetrahydrocannabinol+in+Human+Urine+Following+Tandem+Enzyme-Alkaline+Hydrolysis&rft.au=Abraham%2C+T+T%3BLowe%2C+R+H%3BPirnay%2C+SO%3BDarwin%2C+W+D%3BHuestis%2C+MA&rft.aulast=Abraham&rft.aufirst=T&rft.date=2007-10-01&rft.volume=31&rft.issue=8&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Tetrahydrocannabinol; beta -Glucuronidase; Gas chromatography; Urine; Forensic science; Cannabis; Acetonitrile; pH effects; Ionization; Hydrolysis; Mass spectroscopy; Escherichia coli ER - TY - JOUR T1 - Silent Polymorphisms Speak: How They Affect Pharmacogenomics and the Treatment of Cancer AN - 19790572; 7930188 AB - Polymorphisms in the human genome contribute to wide variations in how individuals respond to medications, either by changing the pharmacokinetics of drugs or by altering the cellular response to therapeutic agents. The goal of the emerging discipline of pharmacogenomics is to personalize therapy based on an individual's genotype. Due to the relatively large frequency of single-nucleotide polymorphisms (SNP) in the human genome, synonymous SNPs are often disregarded in many pharmacogenomic studies based on the assumption that these are silent. We have shown recently that synonymous SNPs in ABCB1 (P-glycoprotein), which is implicated both in determining drug pharmacokinetics and multidrug resistance in human cancer cells, can affect protein conformation and function. We discuss the importance of polymorphisms in drug metabolizing enzymes and transporters in anticancer therapy and suggest that synonymous polymorphisms may play a more significant role than is currently assumed. [Cancer Res 2007; 67(20):9609-12] JF - Cancer Research AU - Sauna, Zuben E AU - Kimchi-Sarfaty, Chava AU - Ambudkar, Suresh V AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, NIH and Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 9609 EP - 9612 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 20 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Protein structure KW - P-Glycoprotein KW - Single-nucleotide polymorphism KW - pharmacogenomics KW - Enzymes KW - Multidrug resistance KW - Cancer KW - Pharmacokinetics KW - G 07880:Human Genetics KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Silent+Polymorphisms+Speak%3A+How+They+Affect+Pharmacogenomics+and+the+Treatment+of+Cancer&rft.au=Sauna%2C+Zuben+E%3BKimchi-Sarfaty%2C+Chava%3BAmbudkar%2C+Suresh+V%3BGottesman%2C+Michael+M&rft.aulast=Sauna&rft.aufirst=Zuben&rft.date=2007-10-01&rft.volume=67&rft.issue=20&rft.spage=9609&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Protein structure; Genomes; P-Glycoprotein; pharmacogenomics; Single-nucleotide polymorphism; Enzymes; Multidrug resistance; Pharmacokinetics; Cancer ER - TY - JOUR T1 - Identification of a Bis-guanylhydrazone [4,4'-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase AN - 19788135; 7616131 AB - Chk2 is a protein kinase involved in the ATM-dependent checkpoint pathway (http://discover.nci.nih.gov/mim). This pathway is activated by genomic instability and DNA damage and results in either cell cycle arrest, to allow DNA repair to occur, or cell death (apoptosis). Chk2 is activated by ATM-mediated phosphorylation and autophosphorylation and in turn phosphorylates its downstream targets (Cdc25A, Cdc25C, BRCA1, p53, Hdmx, E2F1, PP2A, and PML). Inhibition of Chk2 has been proposed to sensitize p53-deficient cells as well as protect normal tissue after exposure to DNA-damaging agents. We have developed a drug-screening program for specific Chk2 inhibitors using a fluorescence polarization assay, immobilized metal ion affinity-based fluorescence polarization (IMAP). This assay detects the degree of phosphorylation of a fluorescently linked substrate by Chk2. From a screen of over 100,000 compounds from the NCI Developmental Therapeutics Program, we identified a bis-guanylhydrazone [4,4'-diacetyldiphenylureabis(guanylhydrazone); NSC 109555] as a lead compound. In vitro data show the specific inhibition of Chk2 kinase activity by NSC 109555 using in vitro kinase assays and kinase-profiling experiments. NSC 109555 was shown to be a competitive inhibitor of Chk2 with respect to ATP, which was supported by docking of NSC 109555 into the ATP binding pocket of the Chk2 catalytic domain. The potency of NSC 109555 was comparable with that of other known Chk2 inhibitors, such as debromohymenialdisine and 2-arylbenzimidazole. These data define a novel chemotype for the development of potent and selective inhibitors of Chk2. This class of drugs may ultimately be useful in combination with current DNA-damaging agents used in the clinic. JF - Molecular Pharmacology AU - Jobson, Andrew G AU - Cardellina, John HII AU - Scudiero, Dominic AU - Kondapaka, Sudhir AU - Zhang, Hongliang AU - Kim, Hijoo AU - Shoemaker, Robert AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (A.G.J., H.Z., H.K., Y.P.) Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 876 EP - 884 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 72 IS - 4 SN - 0026-895X, 0026-895X KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - CHK2 protein KW - Apoptosis KW - Data processing KW - Heavy metals KW - Cell cycle KW - ATP KW - DNA repair KW - p53 protein KW - Fluorescence polarization KW - DNA damage KW - Genomic instability KW - Phosphorylation KW - BRCA1 protein KW - Drugs KW - N 14820:DNA Metabolism & Structure KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19788135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Identification+of+a+Bis-guanylhydrazone+%5B4%2C4%27-Diacetyldiphenylurea-bis%28guanylhydrazone%29%3B+NSC+109555%5D+as+a+Novel+Chemotype+for+Inhibition+of+Chk2+Kinase&rft.au=Jobson%2C+Andrew+G%3BCardellina%2C+John+HII%3BScudiero%2C+Dominic%3BKondapaka%2C+Sudhir%3BZhang%2C+Hongliang%3BKim%2C+Hijoo%3BShoemaker%2C+Robert%3BPommier%2C+Yves&rft.aulast=Jobson&rft.aufirst=Andrew&rft.date=2007-10-01&rft.volume=72&rft.issue=4&rft.spage=876&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CHK2 protein; Data processing; Apoptosis; Heavy metals; Cell cycle; ATP; DNA repair; Fluorescence polarization; p53 protein; DNA damage; Genomic instability; Phosphorylation; BRCA1 protein; Drugs ER - TY - JOUR T1 - Adjuvanting a DNA vaccine with a TLR9 ligand plus Flt3 ligand results in enhanced cellular immunity against the simian immunodeficiency virus AN - 19735325; 7742930 AB - DNA vaccines offer promising strategies for immunization against infections. However, their clinical use requires improvements in immunogenicity. We explored the efficacy of Toll-like receptor (TLR) ligands (TLR-Ls) on augmenting the immunogenicity of a DNA prime-modified vaccinia virus Ankara (MVA) boost vaccine against SIV. Rhesus macaques were injected with Fms-like tyrosine kinase 3 (Flt3)-ligand (FL) to expand dendritic cells (DCs) and were primed with a DNA vaccine encoding immunodeficiency virus antigens mixed with ligands for TLR9 or TLR7/8. Subsequently, the animals were boosted with DNA and twice with recombinant MVA expressing the same antigens. TLR9-L (CpG DNA) mediated activation of DCs in vivo and enhanced the magnitude of antigen-specific CD8 super(+) interferon (IFN) gamma super(+) T cells and polyfunctional CD8 super(+) T cells producing IFN- gamma , tumor necrosis factor alpha , and interleukin 2. Although this trial was designed primarily as an immunogenicity study, we challenged the animals with pathogenic SIVmac sub(251) and observed a reduction in peak viremia and cumulative viral loads in the TLR9-L plus FL-adjuvanted group relative to the unvaccinated group; however, the study design precluded comparisons between the adjuvanted groups and the group vaccinated with DNA/MVA alone. Viral loads were inversely correlated with the magnitude and quality of the immune response. Thus, the immunogenicity of DNA vaccines can be augmented with TLR9-L plus FL. JF - Journal of Experimental Medicine AU - Kwissa, Marcin AU - Amara, Rama R AU - Robinson, Harriet L AU - Moss, Bernard AU - Alkan, Sefik AU - Jabbar, Abdul AU - Villinger, Francois AU - Pulendran, Bali AD - Vaccine Research Center and Yerkes National Primate Research Center, Department of Microbiology & Immunology, and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA 30329. Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, MD 20892. 3M Pharmaceuticals, St. Paul, MN 55144 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 2733 EP - 2746 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 204 IS - 11 SN - 0022-1007, 0022-1007 KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - gamma -Interferon KW - Interleukin 2 KW - Infection KW - Clinical trials KW - Cell activation KW - Dendritic cells KW - DNA vaccines KW - FLT3L protein KW - Lymphocytes T KW - Macaca mulatta KW - TLR9 protein KW - CD8 antigen KW - CpG islands KW - Immunization KW - Interferon KW - Vaccinia virus KW - Immunity (cell-mediated) KW - Immunogenicity KW - Flt3 protein KW - Viremia KW - TLR7 protein KW - Tumor necrosis factor- alpha KW - Immune response KW - Simian immunodeficiency virus KW - Toll-like receptors KW - V 22350:Immunology KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Adjuvanting+a+DNA+vaccine+with+a+TLR9+ligand+plus+Flt3+ligand+results+in+enhanced+cellular+immunity+against+the+simian+immunodeficiency+virus&rft.au=Kwissa%2C+Marcin%3BAmara%2C+Rama+R%3BRobinson%2C+Harriet+L%3BMoss%2C+Bernard%3BAlkan%2C+Sefik%3BJabbar%2C+Abdul%3BVillinger%2C+Francois%3BPulendran%2C+Bali&rft.aulast=Kwissa&rft.aufirst=Marcin&rft.date=2007-10-01&rft.volume=204&rft.issue=11&rft.spage=2733&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Interleukin 2; TLR9 protein; CpG islands; CD8 antigen; Infection; Clinical trials; Immunization; Cell activation; Dendritic cells; Interferon; DNA vaccines; Immunity (cell-mediated); Immunogenicity; Flt3 protein; FLT3L protein; Lymphocytes T; Immune response; Tumor necrosis factor- alpha; TLR7 protein; Viremia; Toll-like receptors; Vaccinia virus; Macaca mulatta; Simian immunodeficiency virus ER - TY - JOUR T1 - An HIV RNase H Inhibitory 1,3,4,5-Tetragalloylapiitol from the African Plant Hylodendron gabunensis AN - 19695737; 8429885 AB - A new compound, 1,3,4,5-tetragalloylapiitol (1), was isolated from the aqueous extract of the plant Hylodendron gabunensis and was found to be a potent inhibitor of RNase H enzymatic activity. The structure of 1 was elucidated by NMR analyses to be an apiitol (2) sugar moiety substituted with four gallic acid residues. Optical rotation measurements of the free sugar following basic hydrolysis indicated that the 3S absolute configuration was the same as that of D-apiitol. Compound 1 inhibited HIV-1, HIV-2, and human RNase H with IC sub(50) values of 0.24, 0.13, and 1.5 mu M, respectively, but it did not show inhibition of E. coli RNase H at 10 mu M. JF - Journal of Natural Products AU - Takada, K AU - Bermingham, A AU - O'Keefe, B R AU - Wamiru, A AU - Beutler, JA AU - Le Grice, SFJ AU - Lloyd, J AU - Gustafson, K R AU - McMahon, J B AD - Molecular Targets Development Program, Center for Cancer Research, National Cancer Institute, Building 1052, Room 121, Frederick, Maryland 21702-1201, USA Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1647 EP - 1649 VL - 70 IS - 10 SN - 0163-3864, 0163-3864 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids KW - Sugar KW - natural products KW - Hydrolysis KW - gallic acid KW - ribonuclease E KW - Human immunodeficiency virus 1 KW - Ribonuclease H KW - Escherichia coli KW - Human immunodeficiency virus 2 KW - N.M.R. KW - Plant extracts KW - Enzymatic activity KW - Absolute configuration KW - A 01340:Antibiotics & Antimicrobials KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19695737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Natural+Products&rft.atitle=An+HIV+RNase+H+Inhibitory+1%2C3%2C4%2C5-Tetragalloylapiitol+from+the+African+Plant+Hylodendron+gabunensis&rft.au=Takada%2C+K%3BBermingham%2C+A%3BO%27Keefe%2C+B+R%3BWamiru%2C+A%3BBeutler%2C+JA%3BLe+Grice%2C+SFJ%3BLloyd%2C+J%3BGustafson%2C+K+R%3BMcMahon%2C+J+B&rft.aulast=Takada&rft.aufirst=K&rft.date=2007-10-01&rft.volume=70&rft.issue=10&rft.spage=1647&rft.isbn=&rft.btitle=&rft.title=Journal+of+Natural+Products&rft.issn=01633864&rft_id=info:doi/10.1021%2Fnp0702279 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sugar; ribonuclease E; Ribonuclease H; N.M.R.; natural products; Enzymatic activity; Plant extracts; Absolute configuration; Hydrolysis; gallic acid; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Escherichia coli DO - http://dx.doi.org/10.1021/np0702279 ER - TY - JOUR T1 - Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1 super(G93A) transgenic mice AN - 19632072; 8755322 AB - Dysfunction of the ALS2 gene has been linked to one form of juvenile onset autosomal recessive amyotrophic lateral sclerosis (ALS). Previous in vitro studies suggest that over-expression of ALS2 protects cells from mutant Cu/Zn superoxide dismutase (SOD1)-induced cytotoxicity. To test whether ALS2 plays a protective role against mutant SOD1-mediated motor neuron degeneration in vivo, we examined the progression of motor neuron disease in SOD1 super(G93A) mice on an ALS2 null background. Our data suggest that deficiency in the ALS2 gene does not affect the pathogenesis of SOD1 super(G93A) mice. JF - Neurobiology of Aging AU - Lin, Xian AU - Shim, Hoon AU - Cai, Huaibin AD - Unit of Transgenesis, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, MSC 3707, 35 Convent Drive, Bethesda, MD 20892, United States, caih@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 1628 EP - 1630 PB - Elsevier Science, Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.com] VL - 28 IS - 10 SN - 0197-4580, 0197-4580 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Amyotrophic lateral sclerosis (ALS) KW - ALS2 KW - Alsin KW - SOD1 KW - SOD1 super(G93A) mice KW - Cytotoxicity KW - Amyotrophic lateral sclerosis KW - Data processing KW - Superoxide dismutase KW - Overexpression KW - Aging KW - Zinc KW - Degeneration KW - Transgenic mice KW - Motor neuron disease KW - W 30925:Genetic Engineering KW - G 07870:Mammals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19632072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+Aging&rft.atitle=Deficiency+in+the+ALS2+gene+does+not+affect+the+motor+neuron+degeneration+in+SOD1+super%28G93A%29+transgenic+mice&rft.au=Lin%2C+Xian%3BShim%2C+Hoon%3BCai%2C+Huaibin&rft.aulast=Lin&rft.aufirst=Xian&rft.date=2007-10-01&rft.volume=28&rft.issue=10&rft.spage=1628&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+Aging&rft.issn=01974580&rft_id=info:doi/10.1016%2Fj.neurobiolaging.2006.07.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Data processing; Amyotrophic lateral sclerosis; Superoxide dismutase; Overexpression; Zinc; Aging; Degeneration; Transgenic mice; Motor neuron disease DO - http://dx.doi.org/10.1016/j.neurobiolaging.2006.07.014 ER - TY - JOUR T1 - Phosphorylation of Histone H2AX in Radiation-Induced Micronuclei AN - 19623452; 8693466 AB - Medvedeva, N. G., Panyutin, I. V., Panyutin, I. G. and Neumann, R. D. Phosphorylation of Histone H2AX in Radiation-Induced Micronuclei. Radiat. Res. 168, 493-498 (2007). DNA double-strand breaks are thought to precede the formation of most radiation-induced micronuclei. Phosphorylation of the histone H2AX is an early indicator of DNA double-strand breaks. Here we studied the phosphorylation status of the histone H2AX in micronuclei after exposure of cultured cells to ionizing radiation or treatment with colchicine. In human astrocytoma SF268 cells, after exposure to gamma radiation, the proportion of gamma -H2AX-positive to gamma -H2AX-negative micronuclei increases. The majority of the gamma -H2AX-positive micronuclei are centromere-negative. The number of gamma -H2AX-positive micronuclei continues to increase even 24 h postirradiation when most gamma -H2AX foci in the main nucleus have disappeared. In contrast, in normal human fibroblasts (BJ), the proportion of gamma -H2AX-positive to gamma -H2AX-negative micronuclei remains constant, and the majority of the centromere-negative cells are gamma -H2AX-negative. Treatment of both cell lines with colchicine results in mostly centromere-positive, gamma -H2AX-negative micronuclei. Immunostaining revealed co-localization of MDC1 and ATM with gamma -H2AX foci in both main nuclei and micronuclei; however, other repair proteins, such as Rad50, 53BP1 and Rad17, that co-localized with gamma -H2AX foci in the main nuclei were not found in the micronuclei. Combination of the micronucleus assay with gamma -H2AX immunostaining provides new insights into the mechanisms of the formation and fate of micronuclei. JF - Radiation Research AU - Medvedeva, Natalia G AU - Panyutin, Irina V AU - Panyutin, Igor G AU - Neumann, Ronald D AD - Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, ipanyuting@mail.nih.gov Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 493 EP - 498 PB - Allen Press, Inc., 810 East Tenth St. VL - 168 IS - 4 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA damage KW - Phosphorylation KW - Astrocytoma KW - Ionizing radiation KW - Micronuclei KW - gamma Radiation KW - Colchicine KW - Nuclei KW - Histone H2A KW - Fibroblasts KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19623452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Phosphorylation+of+Histone+H2AX+in+Radiation-Induced+Micronuclei&rft.au=Medvedeva%2C+Natalia+G%3BPanyutin%2C+Irina+V%3BPanyutin%2C+Igor+G%3BNeumann%2C+Ronald+D&rft.aulast=Medvedeva&rft.aufirst=Natalia&rft.date=2007-10-01&rft.volume=168&rft.issue=4&rft.spage=493&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0788.1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - DNA damage; Astrocytoma; Phosphorylation; Ionizing radiation; Micronuclei; gamma Radiation; Colchicine; Nuclei; Histone H2A; Fibroblasts DO - http://dx.doi.org/10.1667/RR0788.1 ER - TY - JOUR T1 - The IFN-Inducible GTPase LRG47 (Irgm1) Negatively Regulates TLR4-Triggered Proinflammatory Cytokine Production and Prevents Endotoxemia AN - 17281164; 7615066 AB - LRG47/Irgm1, a 47-kDa IFN-inducible GTPase, plays a major role in regulating host resistance as well as the hemopoietic response to intracellular pathogens. LRG47 expression in macrophages has been shown previously to be stimulated in vitro by bacterial LPS, a TLR4 ligand. In this study, we demonstrate that induction of LRG47 by LPS is not dependent on MyD88 signaling, but rather, requires STAT-1 and IFN- beta . In addition, LRG47-deficient mice are highly susceptible to LPS, but not TLR2 ligand-induced shock, an outcome that correlates with enhanced proinflammatory cytokine production in vitro and in vivo. Further analysis revealed that LPS-stimulated LRG47-deficient macrophages display enhanced phosphorylation of p38, a downstream response associated with TLR4/MyD88 rather than IFN- beta /STAT-1 signaling. In contrast, LPS-induced phosphorylation of IFN regulatory factor-3 and expression of IFN- beta or the type I IFN-regulated genes, CCL5 and CCL10, were unaltered in LRG47 super(-/-) cells. Together, these observations indicate that in LPS-stimulated murine macrophages LRG47 is induced by IFN- beta and negatively regulates TLR4 signaling to prevent excess proinflammatory cytokine production and shock. Thus, our findings reveal a new host-protective function for this GTPase in the response to pathogenic encounter. JF - Journal of Immunology AU - Bafica, Andre AU - Feng, Carl G AU - Santiago, Helton C AU - Aliberti, Julio AU - Cheever, Allen AU - Thomas, Karen E AU - Taylor, Gregory A AU - Vogel, Stefanie N AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Division of Immunology, Department of Microbiology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil. Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Division of Molecular Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229. Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201. Geriatric Research, Education, and Clinical Center, VA Medical Center, and. Department of Medicine, Immunology, and Department of Molecular Genetics and Microbiology, and Center for the Study of Aging, Duke University, Durham, NC 27710 Y1 - 2007/10// PY - 2007 DA - Oct 2007 SP - 5514 EP - 5522 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 179 IS - 8 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - beta -Interferon KW - MyD88 protein KW - TLR2 protein KW - Pathogens KW - Inflammation KW - Interferon KW - Phosphorylation KW - Shock KW - Stat1 protein KW - Cytokines KW - Lipopolysaccharides KW - Endotoxemia KW - TLR4 protein KW - Toll-like receptors KW - Guanosinetriphosphatase KW - Signal transduction KW - J 02320:Cell Biology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17281164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=The+IFN-Inducible+GTPase+LRG47+%28Irgm1%29+Negatively+Regulates+TLR4-Triggered+Proinflammatory+Cytokine+Production+and+Prevents+Endotoxemia&rft.au=Bafica%2C+Andre%3BFeng%2C+Carl+G%3BSantiago%2C+Helton+C%3BAliberti%2C+Julio%3BCheever%2C+Allen%3BThomas%2C+Karen+E%3BTaylor%2C+Gregory+A%3BVogel%2C+Stefanie+N%3BSher%2C+Alan&rft.aulast=Bafica&rft.aufirst=Andre&rft.date=2007-10-01&rft.volume=179&rft.issue=8&rft.spage=5514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Macrophages; MyD88 protein; TLR2 protein; Pathogens; Inflammation; Interferon; Shock; Phosphorylation; Stat1 protein; Lipopolysaccharides; Cytokines; Endotoxemia; TLR4 protein; Toll-like receptors; Signal transduction; Guanosinetriphosphatase ER - TY - JOUR T1 - Effect of Leu/Met variation at residue 450 on isomerase activity and protein expression of RPE65 and its modulation by variation at other residues. AN - 68433196; 17960118 AB - RPE65 is the visual cycle retinol isomerase and missense mutations in its gene cause severe retinal dystrophies in man, due to lack of chromophore. While the rate of opsin regeneration in mouse is slower than in man, the methionine (M) variant of mouse RPE65 residue 450 (normally L) is associated with additionally lowered light sensitivity and with resistance to light damage in C57Bl/6 mice, consistent with lowered total activity. We wished to determine how this variant affects RPE65 and if it is modulated by other rodent-specific variations. Site-directed mutagenesis was used to make variant constructs in mouse and dog RPE65, which were tested for isomerase activity by transient transfection in 293-F cells. The isomerase activity of dog RPE65 is slightly higher than mouse. Replacing L at aa450 with M reduces total activity of dog to approximately 70% and mouse to approximately 45% of respective wild type RPE65, and also reduces protein levels of both variants. Replacing K at aa446 in mouse with R, as in other species, reduces total activity in mouse RPE65, whereas the converse case, changing dog aa446 from R to K, increases activity. Exchanges of residues at aa457 and 459 had little overall effect. Human variants at two of these positions, L450R and T457N, had disparate effects, abolishing and augmenting activity, respectively. Wildtype dog RPE65 is more active than wildtype mouse RPE65, perhaps partially explaining the slower regeneration rate in the mouse. The effect of Met at aa450 is more severe in mouse RPE65 than in dog. The effects of variation at residues 446 (K or R) modulate variation at aa450. The sensitivity of aa450 to change is underscored by the abolition of activity in the pathogenic human L450R mutation. These results suggest that subtle species-specific residue changes may be involved in "tuning" of RPE65 activity to required evolutionary criteria. JF - Molecular vision AU - Redmond, T Michael AU - Weber, Charles H AU - Poliakov, Eugenia AU - Yu, Shirley AU - Gentleman, Susan AD - Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, NIH, Bethesda, MD 20892-0706, USA. redmond@helix.nih.gov Y1 - 2007/09/28/ PY - 2007 DA - 2007 Sep 28 SP - 1813 EP - 1821 VL - 13 KW - Carrier Proteins KW - 0 KW - Eye Proteins KW - Arginine KW - 94ZLA3W45F KW - Methionine KW - AE28F7PNPL KW - Oxygenases KW - EC 1.13.- KW - apocarotenal oxygenase, Synechocystis KW - retinoid isomerohydrolase KW - EC 3.1.1.64 KW - cis-trans-Isomerases KW - EC 5.2.- KW - Leucine KW - GMW67QNF9C KW - Lysine KW - K3Z4F929H6 KW - Index Medicus KW - Animals KW - Oxygenases -- metabolism KW - Humans KW - Oxygenases -- genetics KW - Amino Acid Sequence KW - Mice KW - Mutagenesis, Site-Directed KW - Synechocystis -- enzymology KW - Transfection KW - Dogs KW - Molecular Sequence Data KW - Synechocystis -- genetics KW - Cell Line KW - Genetic Variation KW - Carrier Proteins -- metabolism KW - cis-trans-Isomerases -- genetics KW - Eye Proteins -- metabolism KW - Eye Proteins -- genetics KW - Carrier Proteins -- genetics KW - cis-trans-Isomerases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68433196?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+vision&rft.atitle=Effect+of+Leu%2FMet+variation+at+residue+450+on+isomerase+activity+and+protein+expression+of+RPE65+and+its+modulation+by+variation+at+other+residues.&rft.au=Redmond%2C+T+Michael%3BWeber%2C+Charles+H%3BPoliakov%2C+Eugenia%3BYu%2C+Shirley%3BGentleman%2C+Susan&rft.aulast=Redmond&rft.aufirst=T&rft.date=2007-09-28&rft.volume=13&rft.issue=&rft.spage=1813&rft.isbn=&rft.btitle=&rft.title=Molecular+vision&rft.issn=1090-0535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Interplay Between Network Structures, Regulatory Modes and Sensing Mechanisms of Transcription Factors in the Transcriptional Regulatory Network of E. coli AN - 20849807; 8242374 AB - Though the bacterial transcription regulation apparatus is distinct in terms of several structural and functional features from its eukaryotic counterpart, the gross structure of the transcription regulatory network (TRN) is believed to be similar in both superkingdoms. Here, we explore the fine structure of the bacterial TRN and the underlying ''co-regulatory network'' (CRN) to show that despite the superficial similarities to the TRN of the eukaryotic model organism yeast, the bacterial networks display entirely different organizational principles. In particular unlike in eukaryotes, hubs of the bacterial networks are both global regulators and integrators of diverse disparate transcriptional responses. These and other organizational differences might correlate with the fundamental differences in gene and promoter organization in the two superkingdoms, especially the presence of operons and regulons in bacteria. Further we explored to find the interplay, if any, between network structures, mode of regulatory interactions and signal sensing of transcription factors (TFs) in shaping up the bacterial transcriptional regulatory responses. For this purpose, we first classified TFs according to their regulatory mode (activator, repressor or dual regulator) and sensory mechanism (one-component systems responding to internal or external signals, TFs from two-component systems and chromosomal structure modifying TFs) in the bacterial model organism Escherichia coli and then we studied the overall evolutionary optimization of network structures. The incorporation of TFs in different hierarchical elements of the TRN appears to involve on a multi-dimensional selection process depending on regulatory and sensory modes of TFs in motifs, co-regulatory associations between TFs of different functional classes and transcript half-lives. As a result it appears to have generated circuits that allow intricately regulated physiological state changes. We identified the biological significance of most of these optimizations, which can be further used as the basis to explore similar controls in other bacteria. We also show that, though on the larger evolutionary scale, unrelated TFs have evolved to become hubs, within lineages like gamma -proteobacteria there is strong tendency to retain hubs, as well as certain higher-order network modules that have emerged through lineage specific paralog duplications. JF - Journal of Molecular Biology AU - Balaji, S AU - Babu, M M AU - Aravind, L AD - National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, sbalaji@ncbi.nlm.nih.gov Y1 - 2007/09/28/ PY - 2007 DA - 2007 Sep 28 SP - 1108 EP - 1122 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 372 IS - 4 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Promoters KW - Structure-function relationships KW - Transcription factors KW - Escherichia coli KW - Transcription KW - Circuits KW - Ultrastructure KW - Operons KW - Repressors KW - Evolution KW - Models KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20849807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Interplay+Between+Network+Structures%2C+Regulatory+Modes+and+Sensing+Mechanisms+of+Transcription+Factors+in+the+Transcriptional+Regulatory+Network+of+E.+coli&rft.au=Balaji%2C+S%3BBabu%2C+M+M%3BAravind%2C+L&rft.aulast=Balaji&rft.aufirst=S&rft.date=2007-09-28&rft.volume=372&rft.issue=4&rft.spage=1108&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2007.06.084 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Promoters; Structure-function relationships; Transcription factors; Transcription; Circuits; Operons; Ultrastructure; Repressors; Evolution; Models; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2007.06.084 ER - TY - JOUR T1 - An osteopontin fragment is essential for tumor cell invasion in hepatocellular carcinoma. AN - 68317207; 17452979 AB - Tumor cell invasion is a primary event in the metastatic progression of hepatocellular carcinoma (HCC). Our recent results indicate a concordant elevated expression of osteopontin (OPN) and matrix metalloproteinase-9 (MMP-9) in primary metastatic HCC. This study hypothesizes an MMP-9-directed cleavage of OPN that biologically contributes to HCC metastasis. We found that MMP-9 cleaved OPN into specific fragments in vitro, of which three could be identified by Edman degradation amino-acid sequencing. One of these fragments (OPN-5 kDa, residues 167-210) induced low-metastatic HCC cellular invasion via CD44 receptors, which was effectively blocked by the addition of small peptides within the region of OPN-5 kDa. Increased expression of an OPN splice variant (OPN-c) was associated with clinical metastatic HCC. Overexpression of OPN-c with physiological levels of MMP-9 enhanced cellular invasion and coincided with elevated OPN-5 kDa levels. Our data suggest that an alternative splicing event (OPN-c) promotes extracellular cleavage of OPN by MMP-9, thus releasing a distinct region of OPN (OPN-5 kDa) that is essential for HCC cellular invasion and appears to correlate with metastatic potential. The findings of this study may help to improve advanced-stage HCC prognosis and suggest the utility of small peptides for novel therapies. JF - Oncogene AU - Takafuji, V AU - Forgues, M AU - Unsworth, E AU - Goldsmith, P AU - Wang, X W AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2007/09/27/ PY - 2007 DA - 2007 Sep 27 SP - 6361 EP - 6371 VL - 26 IS - 44 SN - 0950-9232, 0950-9232 KW - Antigens, CD44 KW - 0 KW - Peptide Fragments KW - RNA, Messenger KW - Osteopontin KW - 106441-73-0 KW - Matrix Metalloproteinase 9 KW - EC 3.4.24.35 KW - Index Medicus KW - Cell Movement KW - Neoplasm Invasiveness KW - Animals KW - Humans KW - Gene Expression Regulation, Neoplastic -- physiology KW - Prognosis KW - Disease Progression KW - Immunoprecipitation KW - Rabbits KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Antigens, CD44 -- metabolism KW - Chromatography, Affinity KW - Blotting, Western KW - Matrix Metalloproteinase 9 -- metabolism KW - RNA, Messenger -- metabolism KW - Transfection KW - Alternative Splicing KW - Cell Adhesion KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Osteopontin -- physiology KW - Carcinoma, Hepatocellular -- secondary KW - Peptide Fragments -- physiology KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68317207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=An+osteopontin+fragment+is+essential+for+tumor+cell+invasion+in+hepatocellular+carcinoma.&rft.au=Takafuji%2C+V%3BForgues%2C+M%3BUnsworth%2C+E%3BGoldsmith%2C+P%3BWang%2C+X+W&rft.aulast=Takafuji&rft.aufirst=V&rft.date=2007-09-27&rft.volume=26&rft.issue=44&rft.spage=6361&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transition from a Pediatric HIV Intramural Clinical Research Program to Adolescent and Adult Community-Based Care Services: Assessing Transition Readiness AN - 57236116; 200808811 AB - As treatment options have improved, there has been a significant increase in the life expectancy of HIV-infected children and adolescents. For most adolescents, the time comes when it is appropriate to transition from pediatric care to an adult or community-based provider. In response to a program closure, a transition readiness scale was developed. A total of 39 caregivers of HIV-infected youth (ages 10-18) and 12 youth over the age of 18 years were interviewed at two time points. Barriers associated with transition were identified and addressed between visits. Transition readiness improved and state anxiety decreased significantly from the first time point to the last visit (approximately 7 months later). Not having a home social worker was the most reported concern/need identified. Barriers to transition and interventions utilized to assist with transitioning care are discussed. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Social Work in Health Care AU - Wiener, Lori S AU - Zobel, Melissa AU - Battles, Haven AU - Ryder, Celia AD - HIV/AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, 20892 wienerl@mail.nih.gov Y1 - 2007/09/27/ PY - 2007 DA - 2007 Sep 27 SP - 1 EP - 19 PB - The Haworth Press, Binghamton NY VL - 46 IS - 1 SN - 0098-1389, 0098-1389 KW - Health care KW - AIDS KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57236116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Work+in+Health+Care&rft.atitle=Transition+from+a+Pediatric+HIV+Intramural+Clinical+Research+Program+to+Adolescent+and+Adult+Community-Based+Care+Services%3A+Assessing+Transition+Readiness&rft.au=Wiener%2C+Lori+S%3BZobel%2C+Melissa%3BBattles%2C+Haven%3BRyder%2C+Celia&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2007-09-27&rft.volume=46&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Social+Work+in+Health+Care&rft.issn=00981389&rft_id=info:doi/10.1300%2FJ010v46n01_01 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - SWHCDO N1 - SubjectsTermNotLitGenreText - AIDS; Children; Health care DO - http://dx.doi.org/10.1300/J010v46n01_01 ER - TY - JOUR T1 - A role for conditioned ventral tegmental glutamate release in cocaine seeking. AN - 68319962; 17898226 AB - Initiation of cocaine self-administration in rats was associated with release of glutamate in the ventral tegmental area (VTA). The glutamate release was transient, despite continued cocaine intake. Similar glutamate release was seen in rats earning, for the first time, unexpected saline rather than expected cocaine. VTA glutamate release was not seen in similarly trained rats earning saline instead of cocaine for the 13th time. VTA glutamate release was also seen in similarly trained rats that received yoked rather than earned cocaine injections on test day. VTA glutamate release was not seen in a group of rats that had never earned cocaine but had received yoked injections during the training period. Glutamate release was also not seen in a group of rats that received yoked injections but had no previous experience with cocaine. VTA GABA levels did not fluctuate during any aspect of cocaine seeking. Blockade of VTA glutamate receptors appeared to attenuate the rewarding effects of intravenous cocaine injections and blocked almost completely the conditioned responding normally seen during extinction trials. These findings indicate that VTA glutamate release is a conditioned response dependent on an associative process and is not a simple consequence of previous cocaine exposure. The findings implicate glutamate as at least one of the sources of VTA signals from reward-associated environmental stimuli. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - You, Zhi-Bing AU - Wang, Bin AU - Zitzman, Dawnya AU - Azari, Soraya AU - Wise, Roy A AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. zyou@intra.nida.nih.gov Y1 - 2007/09/26/ PY - 2007 DA - 2007 Sep 26 SP - 10546 EP - 10555 VL - 27 IS - 39 KW - Dopamine Uptake Inhibitors KW - 0 KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Rats KW - Microdialysis KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Long-Evans KW - Reinforcement (Psychology) KW - Disease Models, Animal KW - gamma-Aminobutyric Acid -- biosynthesis KW - Male KW - Conditioning (Psychology) -- drug effects KW - Glutamic Acid -- biosynthesis KW - Cocaine-Related Disorders -- physiopathology KW - Behavior, Addictive -- psychology KW - Behavior, Addictive -- metabolism KW - Ventral Tegmental Area -- metabolism KW - Cocaine -- pharmacology KW - Cocaine-Related Disorders -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68319962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=A+role+for+conditioned+ventral+tegmental+glutamate+release+in+cocaine+seeking.&rft.au=You%2C+Zhi-Bing%3BWang%2C+Bin%3BZitzman%2C+Dawnya%3BAzari%2C+Soraya%3BWise%2C+Roy+A&rft.aulast=You&rft.aufirst=Zhi-Bing&rft.date=2007-09-26&rft.volume=27&rft.issue=39&rft.spage=10546&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-term outcomes after repeat doses of antenatal corticosteroids. AN - 68299331; 17881751 AB - Previous trials have shown that repeat courses of antenatal corticosteroids improve some neonatal outcomes in preterm infants but reduce birth weight and increase the risk of intrauterine growth restriction. We report long-term follow-up results of children enrolled in a randomized trial comparing single and repeat courses of antenatal corticosteroids. Women at 23 through 31 weeks of gestation who remained pregnant 7 days after an initial course of corticosteroids were randomly assigned to weekly courses of betamethasone, consisting of 12 mg given intramuscularly and repeated once at 24 hours, or an identical-appearing placebo. We studied the children who were born after these treatments when they were between 2 and 3 years of corrected age. Prespecified outcomes included scores on the Bayley Scales of Infant Development, anthropometric measurements, and the presence of cerebral palsy. A total of 556 infants were available for follow-up; 486 children (87.4%) underwent physical examination and 465 (83.6%) underwent Bayley testing at a mean (+/-SD) corrected age of 29.3+/-4.6 months. There were no significant differences in Bayley results or anthropometric measurements. Six children (2.9% of pregnancies) in the repeat-corticosteroid group had cerebral palsy as compared with one child (0.5% of pregnancies) in the placebo group (relative risk, 5.7; 95% confidence interval, 0.7 to 46.7; P=0.12). Children who had been exposed to repeat as compared with single courses of antenatal corticosteroids did not differ significantly in physical or neurocognitive measures. Although the difference was not statistically significant, the higher rate of cerebral palsy among children who had been exposed to repeat doses of corticosteroids is of concern and warrants further study. (ClinicalTrials.gov number, NCT00015002 [ClinicalTrials.gov].). Copyright 2007 Massachusetts Medical Society. JF - The New England journal of medicine AU - Wapner, Ronald J AU - Sorokin, Yoram AU - Mele, Lisa AU - Johnson, Francee AU - Dudley, Donald J AU - Spong, Catherine Y AU - Peaceman, Alan M AU - Leveno, Kenneth J AU - Malone, Fergal AU - Caritis, Steve N AU - Mercer, Brian AU - Harper, Margaret AU - Rouse, Dwight J AU - Thorp, John M AU - Ramin, Susan AU - Carpenter, Marshall W AU - Gabbe, Steven G AU - National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network AD - Columbia University, New York, USA. ; National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Y1 - 2007/09/20/ PY - 2007 DA - 2007 Sep 20 SP - 1190 EP - 1198 VL - 357 IS - 12 KW - Glucocorticoids KW - 0 KW - Betamethasone KW - 9842X06Q6M KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Health Status KW - Adult KW - Prenatal Care KW - Follow-Up Studies KW - Male KW - Female KW - Pregnancy KW - Child, Preschool KW - Body Size -- drug effects KW - Glucocorticoids -- administration & dosage KW - Child Development -- drug effects KW - Betamethasone -- adverse effects KW - Glucocorticoids -- adverse effects KW - Betamethasone -- administration & dosage KW - Cerebral Palsy -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68299331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Long-term+outcomes+after+repeat+doses+of+antenatal+corticosteroids.&rft.au=Wapner%2C+Ronald+J%3BSorokin%2C+Yoram%3BMele%2C+Lisa%3BJohnson%2C+Francee%3BDudley%2C+Donald+J%3BSpong%2C+Catherine+Y%3BPeaceman%2C+Alan+M%3BLeveno%2C+Kenneth+J%3BMalone%2C+Fergal%3BCaritis%2C+Steve+N%3BMercer%2C+Brian%3BHarper%2C+Margaret%3BRouse%2C+Dwight+J%3BThorp%2C+John+M%3BRamin%2C+Susan%3BCarpenter%2C+Marshall+W%3BGabbe%2C+Steven+G%3BNational+Institute+of+Child+Health+and+Human+Development+Maternal-Fetal+Medicine+Units+Network&rft.aulast=Wapner&rft.aufirst=Ronald&rft.date=2007-09-20&rft.volume=357&rft.issue=12&rft.spage=1190&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-09-20 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - NCT00015002; ClinicalTrials.gov N1 - SuppNotes - Comment In: N Engl J Med. 2007 Sep 20;357(12):1248-50 [17881757] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. AN - 68484136; 17880684 AB - The mechanisms involved in the induction and regulation of inflammation resulting in dopaminergic (DA) neurotoxicity in Parkinson's disease (PD) are complex and incompletely understood. Microglia-mediated inflammation has recently been implicated as a critical mechanism responsible for progressive neurodegeneration. Mesencephalic neuron-glia cultures and reconstituted cultures were used to investigate the molecular mechanisms of sinomenine (SN)-mediated anti-inflammatory and neuroprotective effects in both the lipopolysaccharide (LPS)- and the 1-methyl-4-phenylpyridinium (MPP+)-mediated models of PD. SN showed equivalent efficacy in protecting against DA neuron death in rat midbrain neuron-glial cultures at both micro- and sub-picomolar concentrations, but no protection was seen at nanomolar concentrations. The neuroprotective effect of SN was attributed to inhibition of microglial activation, since SN significantly decreased tumor necrosis factor-alpha (TNF-alpha, prostaglandin E2 (PGE2) and reactive oxygen species (ROS) production by microglia. In addition, from the therapeutic point of view, we focused on sub-picomolar concentration of SN for further mechanistic studies. We found that 10(-14) M of SN failed to protect DA neurons against MPP+-induced toxicity in the absence of microglia. More importantly, SN failed to show a protective effect in neuron-glia cultures from mice lacking functional NADPH oxidase (PHOX), a key enzyme for extracellular superoxide production in immune cells. Furthermore, we demonstrated that SN reduced LPS-induced extracellular ROS production through the inhibition of the PHOX cytosolic subunit p47phoxtranslocation to the cell membrane. Our findings strongly suggest that the protective effects of SN are most likely mediated through the inhibition of microglial PHOX activity. These findings suggest a novel therapy to treat inflammation-mediated neurodegenerative diseases. JF - Journal of neuroinflammation AU - Qian, Li AU - Xu, Zongli AU - Zhang, Wei AU - Wilson, Belinda AU - Hong, Jau-Shyong AU - Flood, Patrick M AD - Comprehensive Center for Inflammatory Disorders, University of North Carolina, Chapel Hill, North Carolina 27599, USA. qianl2@niehs.nih.gov Y1 - 2007/09/19/ PY - 2007 DA - 2007 Sep 19 SP - 23 VL - 4 KW - Anti-Inflammatory Agents KW - 0 KW - Enzyme Inhibitors KW - Morphinans KW - Neuroprotective Agents KW - Tumor Necrosis Factor-alpha KW - NADPH Oxidase KW - EC 1.6.3.1 KW - sinomenine KW - S04A852S5I KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Coculture Techniques KW - Animals KW - Parkinson Disease -- physiopathology KW - Parkinson Disease -- drug therapy KW - Mice, Knockout KW - Neuroprotective Agents -- pharmacology KW - Rats KW - Neuroprotective Agents -- chemistry KW - Rats, Inbred F344 KW - Tumor Necrosis Factor-alpha -- drug effects KW - Anti-Inflammatory Agents -- pharmacology KW - Cell Death -- physiology KW - Enzyme Inhibitors -- therapeutic use KW - Dose-Response Relationship, Drug KW - Enzyme Inhibitors -- chemistry KW - Anti-Inflammatory Agents -- therapeutic use KW - Dopamine -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Animals, Newborn KW - Anti-Inflammatory Agents -- chemistry KW - Mice, Inbred C57BL KW - Enzyme Inhibitors -- pharmacology KW - Tumor Necrosis Factor-alpha -- metabolism KW - Neuroprotective Agents -- therapeutic use KW - Parkinson Disease -- enzymology KW - Cell Line KW - NADPH Oxidase -- metabolism KW - Microglia -- enzymology KW - Morphinans -- chemistry KW - Morphinans -- agonists KW - Encephalitis -- physiopathology KW - Encephalitis -- enzymology KW - Neurons -- drug effects KW - NADPH Oxidase -- antagonists & inhibitors KW - Encephalitis -- drug therapy KW - Neurons -- enzymology KW - Morphinans -- therapeutic use KW - Morphinans -- pharmacology KW - Microglia -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68484136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neuroinflammation&rft.atitle=Sinomenine%2C+a+natural+dextrorotatory+morphinan+analog%2C+is+anti-inflammatory+and+neuroprotective+through+inhibition+of+microglial+NADPH+oxidase.&rft.au=Qian%2C+Li%3BXu%2C+Zongli%3BZhang%2C+Wei%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BFlood%2C+Patrick+M&rft.aulast=Qian&rft.aufirst=Li&rft.date=2007-09-19&rft.volume=4&rft.issue=&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=Journal+of+neuroinflammation&rft.issn=1742-2094&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-12 N1 - Date created - 2007-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chim Acta. 2000 Mar;293(1-2):157-66 [10699430] Neurotox Res. 2005;7(3):193-202 [15897154] J Pharmacol Exp Ther. 2006 Oct;319(1):44-52 [16807359] Prog Neurobiol. 2005 Jun;76(2):77-98 [16081203] J Immunol Methods. 2000 Apr 21;238(1-2):59-68 [10758236] J Pharmacol Exp Ther. 2000 May;293(2):607-17 [10773035] Neuroscience. 2000;97(4):749-56 [10842020] J Neurosci. 2000 Aug 15;20(16):6309-16 [10934283] Exp Neurol. 2001 Jun;169(2):219-30 [11358437] Glia. 2001 Jul;35(1):53-62 [11424192] Life Sci. 2001 Sep 7;69(16):1833-50 [11693264] J Appl Toxicol. 2001 Dec;21 Suppl 1:S87-94 [11920927] J Pharmacol Exp Ther. 2002 Sep;302(3):1212-9 [12183682] FASEB J. 2002 Sep;16(11):1474-6 [12205053] J Pharmacol Exp Ther. 2003 Jan;304(1):1-7 [12490568] Zhong Yao Cai. 2002 Mar;25(3):209-11 [12583167] J Pharmacol Exp Ther. 2003 Apr;305(1):212-8 [12649371] Proc Natl Acad Sci U S A. 2003 May 13;100(10):6145-50 [12721370] FASEB J. 2003 Oct;17(13):1954-6 [12897068] J Biol Chem. 2004 Jan 9;279(2):1415-21 [14578353] Zhongguo Zhong Yao Za Zhi. 2003 Apr;28(4):352-5 [15139149] J Neurosci Res. 2004 Aug 15;77(4):540-51 [15264224] Amyotroph Lateral Scler Other Motor Neuron Disord. 2004 Sep;5(3):164-71 [15512905] Yao Xue Xue Bao. 1965 Aug;12(8):492-5 [5899125] Acta Med Okayama. 1976 Feb;30(1):1-20 [61710] Neurology. 1988 Aug;38(8):1285-91 [3399080] Immunology. 1988 Sep;65(1):47-51 [2846433] FEBS Lett. 1991 Oct 7;291(1):84-6 [1936255] J Immunol. 1992 Oct 15;149(8):2736-41 [1383325] Biochem Pharmacol. 1994 Aug 30;48(5):1050-2 [8093093] Arzneimittelforschung. 1994 Nov;44(11):1223-6 [7848335] Trends Neurosci. 1996 Aug;19(8):312-8 [8843599] Transplantation. 1996 Dec 27;62(12):1855-60 [8990376] Int J Immunopharmacol. 1996 Oct;18(10):529-43 [9080247] J Biol Chem. 1998 Dec 25;273(52):35147-52 [9857051] Planta Med. 1999 Feb;65(1):80-2 [10083851] J Neurosci. 2005 Jan 19;25(3):723-31 [15659610] Biochem J. 2005 Mar 15;386(Pt 3):401-16 [15588255] J Ethnopharmacol. 2005 Apr 8;98(1-2):37-43 [15763362] FASEB J. 2005 Apr;19(6):550-7 [15791005] J Pharmacol Exp Ther. 2006 Nov;319(2):595-603 [16891616] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung cancer survival and functional polymorphisms in MBL2, an innate-immunity gene. AN - 68286026; 17848669 AB - The relationship among chronic inflammation, innate immunity, and cancer is well established. Mannose-binding lectin (MBL) is a key player in innate immunity. Five polymorphisms in the promoter and first exon of the MBL2 gene alter the expression and function of MBL in humans and are associated with inflammation-related disease susceptibility. These five polymorphisms create six well-characterized haplotypes that result in lower (i.e., LYB, LYC, HYD, and LXA) or higher (i.e., HYA and LYA) serum MBL concentrations. We investigated whether survival of patients with lung cancer was associated with these polymorphisms. We used a multivariable Cox proportional hazards model to study the association between MBL2 polymorphisms and their haplotypes and diplotypes in 558 white and 173 African American patients with non-small-cell lung cancer in the Baltimore, MD, area and lung cancer mortality. Smoking history and race were obtained from interviews, tumor stage was obtained from medical records, and cause of death was obtained from the National Death Index. All statistical tests were two-sided. We found a statistically significant association between the X allele of the promoter Y/X polymorphism (which results in a lower serum MBL concentration) and improved lung cancer survival among white patients (risk ratio [RR] of death from lung cancer with X/X or X/Y genotype compared with Y/Y genotype = 0.61, 95% confidence interval [CI] = 0.46 to 0.81) but not among African American patients (RR = 1.11, 95% CI = 0.69 to 1.77). The associations among white patients were strongest in heavy smokers and were independent of stage. We also found a statistically significant interaction between the Y/X polymorphism and race for lung cancer survival (P(interaction) = .019). The MBL2 LXA haplotype and XA/B diplotype, which are also associated with low serum MBL levels, were statistically significantly associated with improved lung cancer survival among white patients. The functional Y/X polymorphism of the innate-immunity gene MBL2 and MBL2 haplotypes and diplotypes appear to be associated with lung cancer survival among white patients. JF - Journal of the National Cancer Institute AU - Pine, Sharon R AU - Mechanic, Leah E AU - Ambs, Stefan AU - Bowman, Elise D AU - Chanock, Stephen J AU - Loffredo, Christopher AU - Shields, Peter G AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4258, USA. Y1 - 2007/09/19/ PY - 2007 DA - 2007 Sep 19 SP - 1401 EP - 1409 VL - 99 IS - 18 KW - Biomarkers, Tumor KW - 0 KW - MBL2 protein, human KW - Mannose-Binding Lectin KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Disease-Free Survival KW - Humans KW - Smoking -- adverse effects KW - Aged KW - Baltimore -- epidemiology KW - Research Design KW - Linkage Disequilibrium KW - Alleles KW - Prospective Studies KW - Haplotypes KW - Adult KW - Confounding Factors (Epidemiology) KW - Case-Control Studies KW - Middle Aged KW - Biomarkers, Tumor -- blood KW - Male KW - Female KW - Proportional Hazards Models KW - Mannose-Binding Lectin -- immunology KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Polymorphism, Genetic KW - Lung Neoplasms -- immunology KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - African Americans -- statistics & numerical data KW - Mannose-Binding Lectin -- blood KW - Lung Neoplasms -- genetics KW - European Continental Ancestry Group -- statistics & numerical data KW - Lung Neoplasms -- mortality KW - Carcinoma, Non-Small-Cell Lung -- immunology KW - Immunity, Innate -- genetics KW - Mannose-Binding Lectin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68286026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Lung+cancer+survival+and+functional+polymorphisms+in+MBL2%2C+an+innate-immunity+gene.&rft.au=Pine%2C+Sharon+R%3BMechanic%2C+Leah+E%3BAmbs%2C+Stefan%3BBowman%2C+Elise+D%3BChanock%2C+Stephen+J%3BLoffredo%2C+Christopher%3BShields%2C+Peter+G%3BHarris%2C+Curtis+C&rft.aulast=Pine&rft.aufirst=Sharon&rft.date=2007-09-19&rft.volume=99&rft.issue=18&rft.spage=1401&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-28 N1 - Date created - 2007-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulating protein alignment in a liquid-crystalline medium through conservative mutagenesis. AN - 68267206; 17718572 JF - Journal of the American Chemical Society AU - Yao, Lishan AU - Bax, Ad AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Deseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. Y1 - 2007/09/19/ PY - 2007 DA - 2007 Sep 19 SP - 11326 EP - 11327 VL - 129 IS - 37 SN - 0002-7863, 0002-7863 KW - Proteins KW - 0 KW - Index Medicus KW - Static Electricity KW - Nuclear Magnetic Resonance, Biomolecular KW - Crystallography, X-Ray KW - Protein Conformation KW - Proteins -- chemistry KW - Liquid Crystals -- chemistry KW - Models, Molecular KW - Proteins -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68267206?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Chemical+Society&rft.atitle=Modulating+protein+alignment+in+a+liquid-crystalline+medium+through+conservative+mutagenesis.&rft.au=Yao%2C+Lishan%3BBax%2C+Ad&rft.aulast=Yao&rft.aufirst=Lishan&rft.date=2007-09-19&rft.volume=129&rft.issue=37&rft.spage=11326&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Chemical+Society&rft.issn=00027863&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Physiological Function and Regulation of Store-Operated TRPC1-Channels. T2 - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AN - 39675743; 4698441 JF - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AU - Ambudkar, Indu S Y1 - 2007/09/18/ PY - 2007 DA - 2007 Sep 18 KW - Physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39675743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.atitle=Physiological+Function+and+Regulation+of+Store-Operated+TRPC1-Channels.&rft.au=Ambudkar%2C+Indu+S&rft.aulast=Ambudkar&rft.aufirst=Indu&rft.date=2007-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Capacitative Calcium Entry Channels: Roles for TRPCs, IP3Rs, STIMs and Orai. T2 - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AN - 39561248; 4698415 JF - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AU - Birnbaumer, Lutz Y1 - 2007/09/18/ PY - 2007 DA - 2007 Sep 18 KW - Calcium channels KW - Transient receptor potential proteins KW - Inositol 1,4,5-trisphosphate receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39561248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.atitle=Capacitative+Calcium+Entry+Channels%3A+Roles+for+TRPCs%2C+IP3Rs%2C+STIMs+and+Orai.&rft.au=Birnbaumer%2C+Lutz&rft.aulast=Birnbaumer&rft.aufirst=Lutz&rft.date=2007-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Store-Activation of CRAC and TRPC Channels. T2 - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AN - 39464576; 4698440 JF - 2007 Keystone Symposia on Transient Receptor Potential Ion Channel Superfamily (E1) AU - Putney Jr, James W Y1 - 2007/09/18/ PY - 2007 DA - 2007 Sep 18 KW - Calcium channels KW - Transient receptor potential proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39464576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.atitle=Store-Activation+of+CRAC+and+TRPC+Channels.&rft.au=Putney+Jr%2C+James+W&rft.aulast=Putney+Jr&rft.aufirst=James&rft.date=2007-09-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Transient+Receptor+Potential+Ion+Channel+Superfamily+%28E1%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Genetic variation in five genes important in telomere biology and risk for breast cancer AN - 20724054; 7793271 AB - Telomeres, consisting of TTAGGG nucleotide repeats and a protein complex at chromosome ends, are critical for maintaining chromosomal stability. Genomic instability, following telomere crisis, may contribute to breast cancer pathogenesis. Many genes critical in telomere biology have limited nucleotide diversity, thus, single nucleotide polymorphisms (SNPs) in this pathway could contribute to breast cancer risk In a population-based study of 1995 breast cancer cases and 2296 controls from Poland, 24 SNPs representing common variation in POT1, TEP1, TERF1, TERF2 and TERT were genotyped. We did not identify any significant associations between individual SNPs or haplotypes and breast cancer risk; however, data suggested that three correlated SNPs in TERT (-1381C > T, -244C > T, and Ex2-659G > A) may be associated with reduced risk of breast cancer among individuals with a family history of breast cancer (odds ratios 0.73, 0.66, and 0.57, 95% confidence intervals 0.53-1.00, 0.46-0.95 and 0.39-0.84, respectively). In conclusion, our data do not support substantial overall associations between SNPs in telomere pathway genes and breast cancer risk. Intriguing associations with variants in TERT among women with a family history of breast cancer warrant follow-up in independent studies. JF - British Journal of Cancer AU - Savage, SA AU - Chanock, S J AU - Lissowska, J AU - Brinton, LA AU - Richesson, D AU - Peplonska, B AU - Bardin-Mikolajczak, A AU - Zatonski, W AU - Szeszenia-Dabrowska, N AU - Garcia-Closas, M AD - Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd.. EPS/7018. Rockville, MD 20852, USA, savagesh@mail.nih.gov Y1 - 2007/09/17/ PY - 2007 DA - 2007 Sep 17 SP - 832 EP - 836 VL - 97 IS - 6 SN - 0007-0920, 0007-0920 KW - Genetics Abstracts; Risk Abstracts KW - Population studies KW - Genetic diversity KW - genetic diversity KW - haplotypes KW - Cancer KW - Genetics KW - risk reduction KW - Telomeres KW - Chromosomes KW - Genomic instability KW - Haplotypes KW - Single-nucleotide polymorphism KW - Poland KW - Proteins KW - Breast cancer KW - G 07880:Human Genetics KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Genetic+variation+in+five+genes+important+in+telomere+biology+and+risk+for+breast+cancer&rft.au=Savage%2C+SA%3BChanock%2C+S+J%3BLissowska%2C+J%3BBrinton%2C+LA%3BRichesson%2C+D%3BPeplonska%2C+B%3BBardin-Mikolajczak%2C+A%3BZatonski%2C+W%3BSzeszenia-Dabrowska%2C+N%3BGarcia-Closas%2C+M&rft.aulast=Savage&rft.aufirst=SA&rft.date=2007-09-17&rft.volume=97&rft.issue=6&rft.spage=832&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603934 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Telomeres; Chromosomes; Genomic instability; Haplotypes; Single-nucleotide polymorphism; Genetic diversity; Population studies; Breast cancer; risk reduction; Genetics; Proteins; genetic diversity; haplotypes; Cancer; Poland DO - http://dx.doi.org/10.1038/sj.bjc.6603934 ER - TY - JOUR T1 - Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model. AN - 68283547; 17875704 AB - The transforming growth factor-beta (TGF-beta) pathway has tumor-suppressor activity in many epithelial tissues. Because TGF-beta is a potent inhibitor of epithelial cell proliferation, it has been widely assumed that this property underlies the tumor-suppressor effect. Here, we have used a xenograft model of breast cancer to show that endogenous TGF-beta has the potential to suppress tumorigenesis through a novel mechanism, involving effects at two distinct levels in the hierarchy of cellular progeny that make up the epithelial component of the tumor. First, TGF-beta reduces the size of the putative cancer stem or early progenitor cell population, and second it promotes differentiation of a more committed, but highly proliferative, progenitor cell population to an intrinsically less proliferative state. We further show that reduced expression of the type II TGF-beta receptor correlates with loss of luminal differentiation in a clinical breast cancer cohort, suggesting that this mechanism may be clinically relevant. At a molecular level, the induction of differentiation by TGF-beta involves down-regulation of Id1, and forced overexpression of Id1 can promote tumorigenesis despite persistence of the antiproliferative effect of TGF-beta. These data suggest new roles for the TGF-beta pathway in regulating tumor cell dynamics that are independent of direct effects on proliferation. JF - Cancer research AU - Tang, Binwu AU - Yoo, Naomi AU - Vu, Mary AU - Mamura, Mizuko AU - Nam, Jeong-Seok AU - Ooshima, Akira AU - Du, Zhijun AU - Desprez, Pierre-Yves AU - Anver, Miriam R AU - Michalowska, Aleksandra M AU - Shih, Joanna AU - Parks, W Tony AU - Wakefield, Lalage M AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 8643 EP - 8652 VL - 67 IS - 18 SN - 0008-5472, 0008-5472 KW - ID1 protein, human KW - 0 KW - Inhibitor of Differentiation Protein 1 KW - Receptors, Transforming Growth Factor beta KW - Transforming Growth Factor beta KW - Protein-Serine-Threonine Kinases KW - EC 2.7.11.1 KW - transforming growth factor-beta type II receptor KW - EC 2.7.11.30 KW - Index Medicus KW - Animals KW - Inhibitor of Differentiation Protein 1 -- genetics KW - Protein-Serine-Threonine Kinases -- deficiency KW - Humans KW - Cell Line, Tumor KW - Mice KW - Mice, Nude KW - Receptors, Transforming Growth Factor beta -- biosynthesis KW - Receptors, Transforming Growth Factor beta -- deficiency KW - Protein-Serine-Threonine Kinases -- biosynthesis KW - Neoplasm Transplantation KW - Gene Expression Profiling KW - Cell Differentiation -- physiology KW - Down-Regulation KW - Transplantation, Heterologous KW - Female KW - Inhibitor of Differentiation Protein 1 -- biosynthesis KW - Breast Neoplasms -- genetics KW - Transforming Growth Factor beta -- physiology KW - Breast Neoplasms -- pathology KW - Neoplastic Stem Cells -- pathology KW - Breast Neoplasms -- metabolism KW - Transforming Growth Factor beta -- deficiency KW - Neoplastic Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68283547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Transforming+growth+factor-beta+can+suppress+tumorigenesis+through+effects+on+the+putative+cancer+stem+or+early+progenitor+cell+and+committed+progeny+in+a+breast+cancer+xenograft+model.&rft.au=Tang%2C+Binwu%3BYoo%2C+Naomi%3BVu%2C+Mary%3BMamura%2C+Mizuko%3BNam%2C+Jeong-Seok%3BOoshima%2C+Akira%3BDu%2C+Zhijun%3BDesprez%2C+Pierre-Yves%3BAnver%2C+Miriam+R%3BMichalowska%2C+Aleksandra+M%3BShih%2C+Joanna%3BParks%2C+W+Tony%3BWakefield%2C+Lalage+M&rft.aulast=Tang&rft.aufirst=Binwu&rft.date=2007-09-15&rft.volume=67&rft.issue=18&rft.spage=8643&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-27 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 1999 Dec 15;91(24):2096-101 [10601380] Nature. 1997 May 22;387(6631):417-22 [9163429] Cancer Res. 2000 Mar 1;60(5):1332-40 [10728695] J Cell Sci. 2000 Nov;113 ( Pt 22):3897-905 [11058077] Breast Cancer Res Treat. 2000 Dec;64(3):235-40 [11200773] Breast Cancer Res Treat. 2001 Jan;65(2):101-10 [11261825] Curr Biol. 2001 Apr 17;11(8):558-68 [11369200] Oncogene. 2001 Apr 26;20(18):2264-72 [11402321] Cancer Res. 1997 Dec 15;57(24):5564-70 [9407968] Cancer Res. 1999 Jul 15;59(14):3379-86 [10416598] Nature. 2004 Nov 18;432(7015):298-306 [15549091] J Mammary Gland Biol Neoplasia. 2005 Jan;10(1):37-47 [15886885] Breast Cancer Res. 2005;7(4):143-8 [15987465] Cancer Res. 2005 Jul 1;65(13):5506-11 [15994920] Cancer Res. 2005 Jul 15;65(14):6207-19 [16024622] Nat Rev Cancer. 2005 Aug;5(8):603-14 [16034366] Cancer Res. 2005 Oct 1;65(19):8944-50 [16204067] Science. 2005 Oct 7;310(5745):68-71 [16210527] Nature. 2006 Jan 5;439(7072):84-8 [16397499] Curr Opin Genet Dev. 2006 Feb;16(1):60-4 [16377171] Cancer Res. 2006 Feb 15;66(4):1883-90; discussion 1895-6 [16488983] Nature. 2006 Feb 23;439(7079):993-7 [16395311] Cancer Cell. 2006 Dec;10(6):515-27 [17157791] Annu Rev Med. 2007;58:267-84 [17002552] Breast Cancer Res Treat. 1995 Jul;35(1):133-44 [7612899] Nat Med. 2001 Sep;7(9):1028-34 [11533706] Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 [11553815] Nat Genet. 2001 Oct;29(2):117-29 [11586292] Oncogene. 2002 Jan 3;21(1):108-18 [11791181] Science. 2002 Oct 18;298(5593):597-600 [12228720] Int J Cancer. 2003 May 10;104(6):677-82 [12640673] Mol Cell. 2003 Apr;11(4):915-26 [12718878] Genes Dev. 2003 May 15;17(10):1253-70 [12756227] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23 [12829800] Am J Pathol. 2003 Oct;163(4):1539-49 [14507660] Cell Prolif. 2003 Oct;36 Suppl 1:73-84 [14521517] J Clin Invest. 2003 Oct;112(7):1116-24 [14523048] Cell. 2003 Oct 31;115(3):281-92 [14636556] Science. 2004 Jan 16;303(5656):359-63 [14671312] Cancer Cell. 2004 Mar;5(3):263-73 [15050918] Int J Oncol. 2004 Jun;24(6):1545-58 [15138599] Nat Genet. 2004 Oct;36(10):1117-21 [15378062] Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14228-33 [15381773] Mol Cell Biol. 1985 Jan;5(1):242-7 [3856735] Cell Growth Differ. 1990 Apr;1(4):161-70 [1707299] Dev Biol. 1995 Mar;168(1):47-61 [7883078] Proc Natl Acad Sci U S A. 1995 May 9;92(10):4254-8 [7753792] Mol Cell Biol. 1995 Jun;15(6):3398-404 [7760836] Am J Pathol. 1996 Jan;148(1):313-9 [8546221] Histopathology. 2000 Feb;36(2):168-77 [10672063] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies. AN - 68281471; 17875771 AB - MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models. The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in humans administered with food on a once weekly schedule and to study the pharmacokinetics of oral MS-275. Patients with refractory solid tumors and lymphoid malignancies were treated with oral MS-275 on a once weekly schedule for 4 weeks of a 6-week cycle. Samples for pharmacokinetic and pharmacodynamic analyses were collected during cycle 1. Protein acetylation in subpopulations of peripheral blood mononuclear cells was measured using a multivariable flow cytometry assay. A total of 22 patients were enrolled, and 19 were considered evaluable for toxicity. The maximum tolerated dose was 6 mg/m(2). No National Cancer Institute Common Toxicity Criteria grade 4 toxicities were observed. Dose-limiting grade 3 toxicities were reversible and consisted of hypophosphatemia, hyponatremia, and hypoalbuminemia. Non-dose-limiting grade 3 myelosuppression was also observed. The mean terminal half-life of MS-275 was 33.9 +/- 26.2 and the T(max) ranged from 0.5 to 24 h. Although there was considerable interpatient variability in pharmacokinetics, the area under the plasma concentration versus time curve increased linearly with dose. MS-275 is well tolerated at a dose of 6 mg/m(2) administered weekly with food for 4 weeks every 6 weeks. Drug exposure increases linearly with dose, and protein acetylation increased in all the subpopulations of peripheral blood mononuclear cells following MS-275 administration. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Kummar, Shivaani AU - Gutierrez, Martin AU - Gardner, Erin R AU - Donovan, Erin AU - Hwang, Kyunghwa AU - Chung, Eun Joo AU - Lee, Min-Jung AU - Maynard, Kim AU - Kalnitskiy, Mikhail AU - Chen, Alice AU - Melillo, Giovanni AU - Ryan, Qin C AU - Conley, Barbara AU - Figg, William D AU - Trepel, Jane B AU - Zwiebel, James AU - Doroshow, James H AU - Murgo, Anthony J AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. kummars@exchange.nih.gov Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 5411 EP - 5417 VL - 13 IS - 18 Pt 1 SN - 1078-0432, 1078-0432 KW - Antineoplastic Agents KW - 0 KW - Benzamides KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Pyridines KW - entinostat KW - 1ZNY4FKK9H KW - Index Medicus KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Drug Administration Schedule KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Neoplasms -- drug therapy KW - Enzyme Inhibitors -- adverse effects KW - Benzamides -- adverse effects KW - Enzyme Inhibitors -- administration & dosage KW - Pyridines -- administration & dosage KW - Antineoplastic Agents -- administration & dosage KW - Maximum Tolerated Dose KW - Benzamides -- administration & dosage KW - Pyridines -- adverse effects KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68281471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+trial+of+MS-275%2C+a+histone+deacetylase+inhibitor%2C+administered+weekly+in+refractory+solid+tumors+and+lymphoid+malignancies.&rft.au=Kummar%2C+Shivaani%3BGutierrez%2C+Martin%3BGardner%2C+Erin+R%3BDonovan%2C+Erin%3BHwang%2C+Kyunghwa%3BChung%2C+Eun+Joo%3BLee%2C+Min-Jung%3BMaynard%2C+Kim%3BKalnitskiy%2C+Mikhail%3BChen%2C+Alice%3BMelillo%2C+Giovanni%3BRyan%2C+Qin+C%3BConley%2C+Barbara%3BFigg%2C+William+D%3BTrepel%2C+Jane+B%3BZwiebel%2C+James%3BDoroshow%2C+James+H%3BMurgo%2C+Anthony+J&rft.aulast=Kummar&rft.aufirst=Shivaani&rft.date=2007-09-15&rft.volume=13&rft.issue=18+Pt+1&rft.spage=5411&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-14 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Parental alcohol use and brain volumes in early- and late-onset alcoholics. AN - 68224488; 17306776 AB - Studies have shown that alcoholics have smaller brain volumes than non-alcoholic cohorts, but an effect of family history (FH) of heavy drinking on brain volume has not been demonstrated. We examined the relationship between an FH of heavy drinking and both brain shrinkage as measured by the ratio of brain volumes to intracranial volume (ICV) as well as maximal brain growth as measured by ICV in early-onset and late-onset alcoholics. With T1-weighted resonance imaging, we measured ICV, brain volume, and white and gray matter volume in adult treatment-seeking late-onset and early-onset alcoholics with either a positive or a negative FH of heavy alcohol use, and in healthy control subjects. We also calculated brain shrinkage using a ratio of soft tissue volumes to ICV. The FH positive alcoholic patients had significantly smaller ICVs than FH negative patients, suggesting smaller premorbid brain growth. Brain shrinkage did not correlate with FH. Late-onset alcoholics showed a greater difference in ICV between FH positive and FH negative patients than early-onset alcoholics. Late-onset FH positive patients also had significantly lower IQ scores than late-onset FH negative patients, and IQ scores were correlated with ICV. These data provide evidence that parental alcohol use might increase risk for alcoholism in offspring in part by a genetic and/or environmental effect that might be related to reduced brain growth. JF - Biological psychiatry AU - Gilman, Jodi M AU - Bjork, James M AU - Hommer, Daniel W AD - Section of Brain Electrophysiology and Imaging, Laboratory of Clinical and Translational Studies, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. gilmanj@mail.nih.gov Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 607 EP - 615 VL - 62 IS - 6 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Magnetic Resonance Imaging KW - Age of Onset KW - Humans KW - Aged KW - Child KW - Intelligence Tests -- statistics & numerical data KW - Atrophy -- pathology KW - Patient Acceptance of Health Care KW - Risk Factors KW - Adult KW - Cohort Studies KW - Middle Aged KW - Female KW - Male KW - Alcohol Drinking -- pathology KW - Alcoholism -- pathology KW - Alcoholism -- epidemiology KW - Brain -- pathology KW - Family KW - Alcohol Drinking -- genetics KW - Alcoholism -- genetics KW - Alcohol Drinking -- epidemiology KW - Child of Impaired Parents KW - Brain -- growth & development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68224488?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Parental+alcohol+use+and+brain+volumes+in+early-+and+late-onset+alcoholics.&rft.au=Gilman%2C+Jodi+M%3BBjork%2C+James+M%3BHommer%2C+Daniel+W&rft.aulast=Gilman&rft.aufirst=Jodi&rft.date=2007-09-15&rft.volume=62&rft.issue=6&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-02 N1 - Date created - 2007-09-03 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Alcohol. 2004 Oct-Nov;34(2-3):133-50 [15902907] Alcohol. 1993 May-Jun;10(3):237-42 [8507394] Ageing Res Rev. 2005 May;4(2):141-94 [15996533] Am J Psychiatry. 2003 Nov;160(11):2038-45 [14594753] Arch Neurol. 2000 Feb;57(2):220-4 [10681081] Am J Psychiatry. 2001 Feb;158(2):198-204 [11156801] Nat Rev Neurosci. 2000 Dec;1(3):191-8 [11257907] Cereb Cortex. 2001 Sep;11(9):816-24 [11532887] Child Abuse Negl. 1994 Aug;18(8):617-33 [7953902] AJNR Am J Neuroradiol. 1995 Feb;16(2):241-51 [7726068] J Stud Alcohol. 1996 Mar;57(2):155-61 [8683964] Science. 1996 Aug 9;273(5276):749-50 [8701325] Alcohol Clin Exp Res. 1996 Sep;20(6):1088-93 [8892532] J Matern Fetal Med. 1997 Nov-Dec;6(6):309-13 [9438210] Alcohol Clin Exp Res. 1998 Apr;22(2):339-44 [9581638] Biol Psychiatry. 1999 May 15;45(10):1271-84 [10349033] Nat Neurosci. 1999 Oct;2(10):859-61 [10491602] Adv Neonatal Care. 2005 Aug;5(4):217-29 [16084479] Biol Psychiatry. 2001 Dec 15;50(12):943-51 [11750890] Psychol Sci. 2003 Nov;14(6):623-8 [14629696] Alcohol Res Health. 2003;27(2):181-5 [15303629] J Stud Alcohol. 1979;40(1):89-116 [376949] J Nerv Ment Dis. 1983 Jul;171(7):444-7 [6864203] Alcohol Clin Exp Res. 1984 Jul-Aug;8(4):362-5 [6385758] J Consult Clin Psychol. 1984 Oct;52(5):919 [6501682] J Clin Psychol. 1985 Sep;41(5):676-80 [4044851] Endocr Rev. 1986 Aug;7(3):284-301 [3527687] Child Abuse Negl. 1987;11(1):15-27 [3548916] Acta Psychiatr Scand. 1987 Mar;75(3):307-14 [3591414] Prog Brain Res. 1988;73:365-87 [2901778] J Neurosci. 1989 May;9(5):1705-11 [2723746] Annu Rev Genet. 1989;23:19-36 [2694930] Prog Brain Res. 1990;86:13-23 [1982366] Alcohol Clin Exp Res. 1991 Jun;15(3):418-27 [1877728] Teratology. 1991 Oct;44(4):373-8 [1962284] Recent Dev Alcohol. 1991;9:301-26 [1758989] Biol Psychiatry. 1992 Apr 15;31(8):794-807 [1643194] J Am Acad Child Adolesc Psychiatry. 1992 Jul;31(4):719-27 [1644736] Am J Psychiatry. 1993 Jan;150(1):130-4 [8417555] Alcohol Clin Exp Res. 1992 Dec;16(6):1078-89 [1471762] Psychiatry Res. 2005 Feb 28;138(2):115-30 [15766635] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Models of beta-amyloid ion channels in the membrane suggest that channel formation in the bilayer is a dynamic process. AN - 68200818; 17526580 AB - Here we model the Alzheimer beta-peptide ion channel with the goal of obtaining insight into the mechanism of amyloid toxicity. The models are built based on NMR data of the oligomers, with the universal U-shaped (strand-turn-strand) motif. After 30-ns simulations in the bilayer, the channel dimensions, shapes and subunit organization are in good agreement with atomic force microscopy (AFM). The models use the Abeta(17-42) pentamer NMR-based coordinates. Extension and bending of the straight oligomers lead to two channel topologies, depending on the direction of the curvature: 1), the polar/charged N-terminal beta-strand of Abeta(17-42) faces the water-filled pore, and the hydrophobic C-terminal beta-strand faces the bilayer (CNpNC; p for pore); and 2), the C-terminal beta-strand faces the solvated pore (NCpCN). In the atomistic simulations in a fully solvated DOPC lipid bilayer, the first (CNpNC) channel preserves the pore and conducts solvent; by contrast, hydrophobic collapse blocks the NCpCN channel. AFM demonstrated open pores and collapsed complexes. The final averaged CNpNC pore dimensions (outer diameter 8 nm; inner diameter approximately 2.5 nm) are in the AFM range (8-12 nm; approximately 2 nm, respectively). Further, in agreement with high-resolution AFM images, during the simulations, the channels spontaneously break into ordered subunits in the bilayer; however, we also observe that the subunits are loosely connected by partially disordered inner beta-sheet, suggesting subunit mobility in the bilayer. The cationic channel has strong selective affinity for Ca(2+), supporting experimental calcium-selective beta-amyloid channels. Membrane permeability and consequent disruption of calcium homeostasis were implicated in cellular degeneration. Consequently, the CNpNC channel topology can sign cell death, offering insight into amyloid toxicity via an ion "trap-release" transport mechanism. The observed loosely connected subunit organization suggests that amyloid channel formation in the bilayer is a dynamic, fluid process involving subunit association, dissociation, and channel rearrangements. JF - Biophysical journal AU - Jang, Hyunbum AU - Zheng, Jie AU - Nussinov, Ruth AD - Center for Cancer Research Nanobiology Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 SP - 1938 EP - 1949 VL - 93 IS - 6 SN - 0006-3495, 0006-3495 KW - Amyloid beta-Peptides KW - 0 KW - Ion Channels KW - Lipid Bilayers KW - Peptide Fragments KW - Protein Subunits KW - amyloid beta-protein (17-42) KW - 155178-13-5 KW - Index Medicus KW - Peptide Fragments -- metabolism KW - Peptide Fragments -- chemistry KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Lipid Bilayers -- chemistry KW - Lipid Bilayers -- metabolism KW - Biophysical Phenomena KW - Protein Structure, Quaternary KW - Protein Conformation KW - Biophysics KW - Ion Channels -- chemistry KW - Amyloid beta-Peptides -- metabolism KW - Amyloid beta-Peptides -- chemistry KW - Ion Channels -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68200818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biophysical+journal&rft.atitle=Models+of+beta-amyloid+ion+channels+in+the+membrane+suggest+that+channel+formation+in+the+bilayer+is+a+dynamic+process.&rft.au=Jang%2C+Hyunbum%3BZheng%2C+Jie%3BNussinov%2C+Ruth&rft.aulast=Jang&rft.aufirst=Hyunbum&rft.date=2007-09-15&rft.volume=93&rft.issue=6&rft.spage=1938&rft.isbn=&rft.btitle=&rft.title=Biophysical+journal&rft.issn=00063495&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-21 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11631-5 [7526400] Biophys J. 1998 Jan;74(1):115-31 [9449316] Biophys J. 1998 Apr;74(4):1622-39 [9545028] J Biol Chem. 1998 May 29;273(22):13379-82 [9593665] Proc Natl Acad Sci U S A. 1998 May 26;95(11):6448-53 [9600986] Biochemistry. 1999 Aug 24;38(34):11189-96 [10460176] J Biol Chem. 2004 Nov 5;279(45):46363-6 [15385542] Biophys J. 2005 Feb;88(2):805-17 [15533925] Nat Rev Microbiol. 2005 Mar;3(3):238-50 [15703760] Annu Rev Biophys Biomol Struct. 2005;34:153-71 [15869387] Nature. 2005 Jun 9;435(7043):773-8 [15944695] Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10427-32 [16020533] J Biol Chem. 2000 Feb 18;275(7):4713-8 [10671502] FASEB J. 2000 Jun;14(9):1233-43 [10834945] FASEB J. 2000 Jun;14(9):1244-54 [10834946] J Struct Biol. 2000 Jun;130(2-3):88-98 [10940217] Biochim Biophys Acta. 2000 Jul 26;1502(1):16-30 [10899428] Brain Res Bull. 2000 Nov 1;53(4):389-97 [11136994] FASEB J. 2001 Nov;15(13):2433-44 [11689468] Nature. 2002 Apr 4;416(6880):507-11 [11932737] Nature. 2002 Apr 4;416(6880):535-9 [11932745] Nature. 2002 Jul 18;418(6895):291 [12124613] J Neurosci Res. 2002 Sep 1;69(5):567-77 [12210822] Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14126-31 [12391326] Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):330-5 [12506200] J Mol Biol. 2003 Sep 26;332(4):795-808 [12972252] J Mol Biol. 2003 Oct 24;333(3):493-514 [14556740] Curr Opin Struct Biol. 2004 Feb;14(1):96-103 [15102455] Biophys J. 2004 Jun;86(6):3556-75 [15189854] Biophys J. 2004 Jul;87(1):129-45 [15240452] Nature. 1991 Dec 12;354(6353):432-3 [1684220] Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71 [8380642] Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8209-13 [8367484] J Neurochem. 1994 Jan;62(1):372-5 [8263540] Biophys J. 1993 Dec;65(6):2455-60 [7508762] J Am Chem Soc. 2005 Oct 5;127(39):13472-3 [16190691] J Comput Chem. 2005 Dec;26(16):1781-802 [16222654] Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17342-7 [16293696] Biophys J. 2005 Dec;89(6):4111-21 [16183878] Biochemistry. 2006 Jan 17;45(2):498-512 [16401079] J Mol Biol. 2006 Feb 24;356(3):759-70 [16403524] Biophys J. 2006 Oct 15;91(8):2848-59 [16861271] Phys Biol. 2006 Sep;3(3):P1-4 [17021379] Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16248-53 [17060612] Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18119-24 [17108084] Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12 [17245412] BMC Struct Biol. 2007;7:21 [17407565] Mol Cell Biochem. 1994 Nov 23;140(2):119-25 [7898484] Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1710-5 [8643694] Biophys J. 1996 Sep;71(3):1348-9 [8874009] Biophys J. 1996 Sep;71(3):1350-5 [8874010] Biophys J. 1997 Nov;73(5):2376-92 [9370432] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fulminant Mulch Pneumonitis: An Emergency Presentation of Chronic Granulomatous Disease AN - 20850415; 8231474 AB - Background. Chronic granulomatous disease (CGD) is associated with multiple and recurrent infections. In patients with CGD, invasive pulmonary infection with Aspergillus species remains the greatest cause of mortality and is typically insidious In onset. Acute fulminant presentations of fungal pneumonia are catastrophic. Methods. Case records, radiograph findings, and microbiologic examination findings of patients with CGD who had acute presentations of dyspnea and diffuse pulmonary infiltrates caused by invasive fungal infection were reviewed and excerpted onto a standard format. Results. From 1991 through 2004, 9 patients who either were known to have CGD or who received a subsequent diagnosis of CGD presented with fever and new onset dyspnea. Eight patients were hypoxic at presentation; bilateral pulmonary infiltrates were noted at presentation in 6 patients and developed within 2 days after initial symptoms in 2 patients. All patients received diagnoses of invasive filamentous fungi; 4 patients had specimens that also grew Streptomyces species on culture. All patients had been exposed to aerosolized mulch or organic material 1-10 days prior to the onset of symptoms. Cases did not occur in the winter. Five patients died. Two patients, 14 years of age and 23 years of age, who had no antecedent history of recognized immunodeficiency, were found to have p47 super(phox)-deflcient CGD. Conclusions. Acute fulminant invasive fungal pneumonia in the absence of exogenous immunosuppression is a medical emergency that is highly associated with CGD. Correct diagnosis has important implications for immediate therapy, genetic counseling, and subsequent prophylaxis. JF - Clinical Infectious Diseases AU - Siddiqul, S AU - Anderson, V L AU - Hilligoss, D M AU - Abinun, M AU - Kuijpers, T W AU - Masur, H AU - Witebsky, F G AU - Shea, Y R AU - Gallin, JI AU - Malech, H L AU - Holland, S M AD - Laboratory of Clinical Infectious Diseases, National Institutes of Health, Bldg. 10, CRC B3-4141, MSC 1684, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2007/09/15/ PY - 2007 DA - 2007 Sep 15 VL - 45 IS - 6 SN - 1058-4838, 1058-4838 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Mortality KW - Mulches KW - Age KW - Fungi KW - Respiration KW - Immunodeficiency KW - Aspergillus KW - Fever KW - Lung KW - Pneumonitis KW - Hypoxia KW - Streptomyces KW - Prophylaxis KW - Recurrent infection KW - Radiography KW - Chronic granulomatous disease KW - Dyspnea KW - Pneumonia KW - Immunosuppression KW - K 03400:Human Diseases KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20850415?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Infectious+Diseases&rft.atitle=Fulminant+Mulch+Pneumonitis%3A+An+Emergency+Presentation+of+Chronic+Granulomatous+Disease&rft.au=Siddiqul%2C+S%3BAnderson%2C+V+L%3BHilligoss%2C+D+M%3BAbinun%2C+M%3BKuijpers%2C+T+W%3BMasur%2C+H%3BWitebsky%2C+F+G%3BShea%2C+Y+R%3BGallin%2C+JI%3BMalech%2C+H+L%3BHolland%2C+S+M&rft.aulast=Siddiqul&rft.aufirst=S&rft.date=2007-09-15&rft.volume=45&rft.issue=6&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Clinical+Infectious+Diseases&rft.issn=10584838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mulches; Mortality; Age; Respiration; Fungi; Immunodeficiency; Fever; Lung; Hypoxia; Pneumonitis; Prophylaxis; Recurrent infection; Radiography; Chronic granulomatous disease; Dyspnea; Pneumonia; Immunosuppression; Streptomyces; Aspergillus ER - TY - CPAPER T1 - The Seroprevalence Rate of Leishmaniasis among Domestic Dogs in Three Foci of Tbilisi, Georgia T2 - 2007 Centenary Conference of the Royal Society of Tropical Medicine and Hygiene AN - 39502741; 4726349 JF - 2007 Centenary Conference of the Royal Society of Tropical Medicine and Hygiene AU - Giorgobiani, E AU - Chanturia, G AU - Chitadze, N AU - Sacks, D AU - Kamhawi, S H AU - Imnadze, P Y1 - 2007/09/13/ PY - 2007 DA - 2007 Sep 13 KW - USA, Georgia KW - Leishmaniasis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39502741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Centenary+Conference+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Seroprevalence+Rate+of+Leishmaniasis+among+Domestic+Dogs+in+Three+Foci+of+Tbilisi%2C+Georgia&rft.au=Giorgobiani%2C+E%3BChanturia%2C+G%3BChitadze%2C+N%3BSacks%2C+D%3BKamhawi%2C+S+H%3BImnadze%2C+P&rft.aulast=Giorgobiani&rft.aufirst=E&rft.date=2007-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Centenary+Conference+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.rstmh.elsevier.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differential antiviral effect of PEG-interferon- alpha -2b on HIV and HCV in the treatment of HIV/HCV co-infected patients AN - 19876059; 7625917 AB - Objective: The major antiviral effect of interferon (IFN)- alpha on hepatitis C virus (HCV) is blocking of virion production from infected cells. We now investigate the previously unknown mechanism of action of IFN- alpha against HIV. Methods: HIV kinetics in parallel to HCV kinetics and IFN pharmacokinetics during pegylated-IFN- alpha -2b (1.5 mu g/Kg q.w., PEG-IFN) and ribavirin (1 -1.2 g daily) treatment in nine HIV patients co-infected with HCV genotype 1 were analyzed. In vivo modeling predictions of suppression of HIV replication by PEG-IFN in CD8-depleted peripheral blood mononuclear cells were verified by in vitro experiments. Results: HCV and HIV show different viral decline patterns after administration of PEG-IFN. Unlike the bi-phasic decline shown by HCV, HIV shows a slow continuous decline during the first week, with no rebound when PEG-IFN levels decline. Fitting of HIV kinetics with known half-lives of free virus and infected cells indicates that the major effect of IFN on HIV is to block de novo infection rather than to block virion production. The magnitude of the antiviral effect is similar (mean 1.1 log sub(10) decline at 7 days) to those of direct anti-HIV drugs, but shows an inverse correlation with baseline viremia. In vitro studies show that preincubation with IFN renders a suppression of HIV replication superior to that of treatment postinfection, thus corroborating the mathematical analysis in vivo. Conclusion: The complimentary antiviral properties of IFN- alpha and antiretroviral therapy suggest a role for pharmacokinetically improved formulations of IFN as part of salvage therapy for HIV-infected individuals. JF - AIDS AU - Neumann, A U AU - Polis, MA AU - Rozenberg, L AU - Jackson, JO AU - Reitano, K N AU - McLaughlin, M AU - Koratich, C AU - Dewar, R L AU - Masur, H AU - Haagmans, B L AU - Kottilil, S AD - Immunopathogenesis Section, Laboratory of Immunoregulation, NIAID, NIH, Bldg10, Rm. 11N204, Bethesda, MD 20892, USA, skottilil@niaid.nih.gov Y1 - 2007/09/12/ PY - 2007 DA - 2007 Sep 12 SP - 1855 EP - 1865 VL - 21 IS - 14 SN - 0269-9370, 0269-9370 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Virions KW - Replication KW - antiretroviral therapy KW - Ribavirin KW - CD8 antigen KW - Genotypes KW - Infection KW - Antiviral activity KW - Pharmacokinetics KW - Interferon KW - Peripheral blood mononuclear cells KW - Hepatitis C virus KW - Antiviral agents KW - Human immunodeficiency virus KW - Kinetics KW - alpha -Interferon KW - Viremia KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Differential+antiviral+effect+of+PEG-interferon-+alpha+-2b+on+HIV+and+HCV+in+the+treatment+of+HIV%2FHCV+co-infected+patients&rft.au=Neumann%2C+A+U%3BPolis%2C+MA%3BRozenberg%2C+L%3BJackson%2C+JO%3BReitano%2C+K+N%3BMcLaughlin%2C+M%3BKoratich%2C+C%3BDewar%2C+R+L%3BMasur%2C+H%3BHaagmans%2C+B+L%3BKottilil%2C+S&rft.aulast=Neumann&rft.aufirst=A&rft.date=2007-09-12&rft.volume=21&rft.issue=14&rft.spage=1855&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Replication; Ribavirin; antiretroviral therapy; Genotypes; CD8 antigen; Antiviral activity; Infection; Pharmacokinetics; Interferon; Peripheral blood mononuclear cells; Antiviral agents; Kinetics; alpha -Interferon; Viremia; Hepatitis C virus; Human immunodeficiency virus ER - TY - JOUR T1 - Phosphorylation of claudin-4 by PKCepsilon regulates tight junction barrier function in ovarian cancer cells. AN - 68205659; 17678893 AB - Claudin proteins belong to a large family of transmembrane proteins essential to the formation and maintenance of tight junctions (TJs). In ovarian cancer, TJ protein claudin-4 is frequently overexpressed and may have roles in survival and invasion, but the molecular mechanisms underlying its regulation are poorly understood. In this report, we show that claudin-4 can be phosphorylated by protein kinase C (PKC) at Thr189 and Ser194 in ovarian cancer cells and overexpression of a claudin-4 mutant protein mimicking the phosphorylated state results in the disruption of the barrier function. Furthermore, upon phorbol ester-mediated PKC activation of OVCA433 cells, TJ strength is decreased and claudin-4 localization is altered. Analyses using PKC inhibitors and siRNA suggest that PKCepsilon, an isoform typically expressed in ovarian cancer cells, may be important in the TPA-mediated claudin-4 phosphorylation and weakening of the TJs. Furthermore, immunofluorescence studies showed that claudin-4 and PKCepsilon are co-localized at the TJs in these cells. The modulation of claudin-4 activity by PKCepsilon may not only provide a mechanism for disrupting TJ function in ovarian cancer, but may also be important in the regulation of TJ function in normal epithelial cells. JF - Experimental cell research AU - D'Souza, Theresa AU - Indig, Fred E AU - Morin, Patrice J AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, Baltimore, MD 21224, USA. Y1 - 2007/09/10/ PY - 2007 DA - 2007 Sep 10 SP - 3364 EP - 3375 VL - 313 IS - 15 SN - 0014-4827, 0014-4827 KW - CLDN4 protein, human KW - 0 KW - Claudin-4 KW - Indoles KW - Maleimides KW - Membrane Proteins KW - Protein Isoforms KW - Protein Kinase C-epsilon KW - EC 2.7.11.13 KW - bisindolylmaleimide I KW - L79H6N0V6C KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Phosphorylation KW - Protein Isoforms -- metabolism KW - Humans KW - Protein Isoforms -- antagonists & inhibitors KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Indoles -- pharmacology KW - Cell Line, Tumor KW - Mutation KW - Signal Transduction KW - Female KW - Maleimides -- pharmacology KW - Ovarian Neoplasms -- metabolism KW - Protein Kinase C-epsilon -- metabolism KW - Tight Junctions -- physiology KW - Membrane Proteins -- metabolism KW - Protein Kinase C-epsilon -- antagonists & inhibitors KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68205659?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Phosphorylation+of+claudin-4+by+PKCepsilon+regulates+tight+junction+barrier+function+in+ovarian+cancer+cells.&rft.au=D%27Souza%2C+Theresa%3BIndig%2C+Fred+E%3BMorin%2C+Patrice+J&rft.aulast=D%27Souza&rft.aufirst=Theresa&rft.date=2007-09-10&rft.volume=313&rft.issue=15&rft.spage=3364&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-21 N1 - Date created - 2007-08-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Gynecol Oncol. 2006 Nov;103(2):405-16 [16725184] Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6072-6 [7597083] Br J Cancer. 2000 Jan;82(1):34-8 [10638963] Cancer Res. 2001 Nov 1;61(21):7878-81 [11691807] Methods Enzymol. 1991;200:121-34 [1835511] J Biol Chem. 1993 May 5;268(13):9194-7 [8486620] Mol Biol Cell. 2000 Mar;11(3):849-62 [10712504] Br J Cancer. 2000 Mar;82(5):1063-9 [10737390] Trends Pharmacol Sci. 2000 May;21(5):181-7 [10785652] Adv Drug Deliv Rev. 2000 Jun 30;41(3):283-301 [10854687] Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G250-4 [10915631] Kidney Int. 2000 Sep;58(3):1004-15 [10972665] Am J Physiol Gastrointest Liver Physiol. 2000 Oct;279(4):G660-5 [11005751] Cancer Res. 2000 Nov 15;60(22):6281-7 [11103784] Ann N Y Acad Sci. 2000;915:231-6 [11193580] Cancer Res. 2001 Feb 1;61(3):808-12 [11221859] J Cell Biol. 2001 Apr 16;153(2):263-72 [11309408] Am J Physiol Cell Physiol. 2001 Aug;281(2):C649-61 [11443064] Gastroenterology. 2001 Sep;121(3):678-84 [11522752] Biochem J. 2001 Dec 1;360(Pt 2):295-304 [11716757] J Cell Biochem. 2002;85(4):785-97 [11968018] J Biol Chem. 2002 Jun 14;277(24):22073-84 [11934885] EMBO J. 2002 Jul 15;21(14):3608-19 [12110574] J Cell Biol. 2002 Sep 2;158(5):967-78 [12196510] J Biochem. 2002 Dec;132(6):847-52 [12473185] Prog Biophys Mol Biol. 2003 Jan;81(1):1-44 [12475568] J Cell Biol. 2003 Feb 3;160(3):423-32 [12566432] Biochem Biophys Res Commun. 2003 Mar 7;302(2):324-9 [12604349] Nat Rev Mol Cell Biol. 2003 Mar;4(3):225-36 [12612641] Oncogene. 2003 Apr 3;22(13):2021-33 [12673207] Clin Cancer Res. 2003 Jul;9(7):2567-75 [12855632] Int J Oncol. 2003 Sep;23(3):633-9 [12888898] Cancer Res. 2003 Oct 1;63(19):6265-71 [14559813] J Enzyme Inhib Med Chem. 2003 Aug;18(4):357-70 [14567551] Exp Cell Res. 2003 Nov 1;290(2):275-88 [14567987] Exp Eye Res. 2004 Jan;78(1):125-36 [14667834] Exp Cell Res. 2004 Apr 15;295(1):36-47 [15051488] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4690-4 [15070779] Am J Pathol. 2004 May;164(5):1627-33 [15111309] Am J Physiol Cell Physiol. 2004 Jun;286(6):C1213-28 [15151915] Clin Cancer Res. 2004 May 15;10(10):3291-300 [15161682] Reproduction. 2004 Jun;127(6):653-67 [15175502] Clin Cancer Res. 2004 Jul 1;10(13):4427-36 [15240533] Am J Pathol. 2004 Aug;165(2):397-414 [15277215] Int J Cancer. 2004 Oct 20;112(1):14-25 [15305371] Exp Cell Res. 2004 Oct 15;300(1):202-12 [15383327] Oncology. 2004;67(1):1-10 [15459489] Biochem Pharmacol. 1991 Sep 12;42(7):1427-32 [1930266] Int J Cancer. 1995 Aug 9;62(4):457-60 [7635571] J Cell Biol. 1997 Jun 16;137(6):1393-401 [9182670] J Membr Biol. 1999 Jul 15;170(2):147-56 [10430658] Adv Drug Deliv Rev. 2005 Apr 25;57(6):919-28 [15820559] J Pharmacol Exp Ther. 2005 Jun;313(3):962-82 [15900076] Alcohol Clin Exp Res. 2005 Jun;29(6):999-1009 [15976526] J Biol Chem. 2005 Jul 15;280(28):26233-40 [15905176] Cancer Res. 2005 Aug 15;65(16):7378-85 [16103090] Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12519-24 [16116079] Cancer Res. 2005 Sep 15;65(18):8366-71 [16166314] Cancer Res. 2005 Nov 1;65(21):9603-6 [16266975] Int J Biochem Cell Biol. 2006 Feb;38(2):222-33 [16257565] J Biol Chem. 2005 Dec 23;280(51):42375-82 [16236711] Int J Cancer. 2006 Apr 15;118(8):1884-91 [16287068] J Biol Chem. 2006 Mar 31;281(13):8379-88 [16439355] J Cell Sci. 2006 May 1;119(Pt 9):1781-9 [16608877] Cancer Res. 2006 May 1;66(9):4627-35 [16651413] Mol Carcinog. 2006 Jun;45(6):381-8 [16683253] Biochem Biophys Res Commun. 2006 Oct 20;349(2):804-8 [16949040] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Crk is Required for Reelin-mediated Hippocampal Dendrite Outgrowth. T2 - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AN - 39745119; 4736453 JF - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AU - Matsuki, Tohru AU - Pramatarova, Albena AU - Howell, Brian_W. Y1 - 2007/09/10/ PY - 2007 DA - 2007 Sep 10 KW - Dendrites KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39745119?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+Japan+Neuroscience+Society%2C+50th+Annual+Meeting+of+the+Japanese+Society+for+Neurochemistry+and+17th+Annual+Meeting+of+the+Japanese+Neural+Network+Society+%28Neuro+2007%29&rft.atitle=Crk+is+Required+for+Reelin-mediated+Hippocampal+Dendrite+Outgrowth.&rft.au=Matsuki%2C+Tohru%3BPramatarova%2C+Albena%3BHowell%2C+Brian_W.&rft.aulast=Matsuki&rft.aufirst=Tohru&rft.date=2007-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+Japan+Neuroscience+Society%2C+50th+Annual+Meeting+of+the+Japanese+Society+for+Neurochemistry+and+17th+Annual+Meeting+of+the+Japanese+Neural+Network+Society+%28Neuro+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.jp/neuro2007/program/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Primate Lateral Habenula in Negative Motivational Control of Behavior. T2 - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AN - 39616460; 4735397 JF - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AU - Matsumoto, Masayuki AU - Hikosaka, Okihide Y1 - 2007/09/10/ PY - 2007 DA - 2007 Sep 10 KW - Primates KW - Habenula KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39616460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+Japan+Neuroscience+Society%2C+50th+Annual+Meeting+of+the+Japanese+Society+for+Neurochemistry+and+17th+Annual+Meeting+of+the+Japanese+Neural+Network+Society+%28Neuro+2007%29&rft.atitle=Role+of+the+Primate+Lateral+Habenula+in+Negative+Motivational+Control+of+Behavior.&rft.au=Matsumoto%2C+Masayuki%3BHikosaka%2C+Okihide&rft.aulast=Matsumoto&rft.aufirst=Masayuki&rft.date=2007-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=30th+Annual+Meeting+of+Japan+Neuroscience+Society%2C+50th+Annual+Meeting+of+the+Japanese+Society+for+Neurochemistry+and+17th+Annual+Meeting+of+the+Japanese+Neural+Network+Society+%28Neuro+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www2.convention.jp/neuro2007/program/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Injury-related Molecular Profiling of the Subgranular Zone in Young and Aged Brain, Relative to Neurogenesis. T2 - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AN - 39563562; 4736497 JF - 30th Annual Meeting of Japan Neuroscience Society, 50th Annual Meeting of the Japanese Society for Neurochemistry and 17th Annual Meeting of the Japanese Neural Network Society (Neuro 2007) AU - Aoyama, Mineyoshi AU - Grissom, Sherry AU - Gohlke, Julia AU - Asai, Kiyofumi AU - Harry, G_Jean Y1 - 2007/09/10/ PY - 2007 DA - 2007 Sep 10 KW - Brain KW - Neurogenesis KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39563562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=30th+Annual+Meeting+of+Japan+Neuroscience+Society%2C+50th+Annual+Meeting+of+the+Japanese+Society+for+Neurochemistry+and+17th+Annual+Meeting+of+the+Japanese+Neural+Network+Society+%28Neuro+2007%29&rft.atitle=Injury-related+Molecular+Profiling+of+the+Subgranular+Zone+in+Young+and+Aged+Brain%2C+Relative+to+Neurogenesis.&rft.au=Aoyama%2C+Mineyoshi%3BGrissom%2C+Sherry%3BGohlke%2C+Julia%3BAsai%2C+Kiyofumi%3BHarry%2C+G_Jean&rft.aulast=Aoyama&rft.aufirst=Mineyoshi&rft.date=2007-09-10&rft.volume=2&rft.issue=3-4&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Plant+foods+for+man&rft.issn=03062686&rft_id=info:doi/ L2 - http://www2.convention.jp/neuro2007/program/index.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. AN - 68252906; 17826169 AB - Mental disorders are major causes of disability worldwide, including in the low-income and middle-income countries least able to bear such burdens. We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment. Face-to-face household surveys were undertaken with 84,850 community adult respondents in low-income or middle-income (Colombia, Lebanon, Mexico, Nigeria, China, South Africa, Ukraine) and high-income countries (Belgium, France, Germany, Israel, Italy, Japan, Netherlands, New Zealand, Spain, USA). Prevalence and severity of mental disorders over 12 months, and mental health service use, were assessed with the WMH composite international diagnostic interview. Logistic regression analysis was used to study sociodemographic predictors of receiving any 12-month services. The number of respondents using any 12-month mental health services (57 [2%; Nigeria] to 1477 [18%; USA]) was generally lower in developing than in developed countries, and the proportion receiving services tended to correspond to countries' percentages of gross domestic product spent on health care. Although seriousness of disorder was related to service use, only five (11%; China) to 46 (61%; Belgium) of patients with severe disorders received any care in the previous year. General medical sectors were the largest sources of mental health services. For respondents initiating treatments, 152 (70%; Germany) to 129 (95%; Italy) received any follow-up care, and one (10%; Nigeria) to 113 (42%; France) received treatments meeting minimum standards for adequacy. Patients who were male, married, less-educated, and at the extremes of age or income were treated less. Unmet needs for mental health treatment are pervasive and especially concerning in less-developed countries. Alleviation of these unmet needs will require expansion and optimum allocation of treatment resources. JF - Lancet (London, England) AU - Wang, Philip S AU - Aguilar-Gaxiola, Sergio AU - Alonso, Jordi AU - Angermeyer, Matthias C AU - Borges, Guilherme AU - Bromet, Evelyn J AU - Bruffaerts, Ronny AU - de Girolamo, Giovanni AU - de Graaf, Ron AU - Gureje, Oye AU - Haro, Josep Maria AU - Karam, Elie G AU - Kessler, Ronald C AU - Kovess, Viviane AU - Lane, Michael C AU - Lee, Sing AU - Levinson, Daphna AU - Ono, Yutaka AU - Petukhova, Maria AU - Posada-Villa, José AU - Seedat, Soraya AU - Wells, J Elisabeth AD - Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA. wangphi@mail.nih.gov Y1 - 2007/09/08/ PY - 2007 DA - 2007 Sep 08 SP - 841 EP - 850 VL - 370 IS - 9590 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Logistic Models KW - Humans KW - Health Surveys KW - Anxiety -- therapy KW - Prevalence KW - Income KW - Substance-Related Disorders -- therapy KW - World Health Organization KW - Mental Disorders -- therapy KW - Mental Disorders -- epidemiology KW - Mental Disorders -- classification KW - Mental Health Services -- utilization KW - Population Surveillance -- methods KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68252906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Use+of+mental+health+services+for+anxiety%2C+mood%2C+and+substance+disorders+in+17+countries+in+the+WHO+world+mental+health+surveys.&rft.au=Wang%2C+Philip+S%3BAguilar-Gaxiola%2C+Sergio%3BAlonso%2C+Jordi%3BAngermeyer%2C+Matthias+C%3BBorges%2C+Guilherme%3BBromet%2C+Evelyn+J%3BBruffaerts%2C+Ronny%3Bde+Girolamo%2C+Giovanni%3Bde+Graaf%2C+Ron%3BGureje%2C+Oye%3BHaro%2C+Josep+Maria%3BKaram%2C+Elie+G%3BKessler%2C+Ronald+C%3BKovess%2C+Viviane%3BLane%2C+Michael+C%3BLee%2C+Sing%3BLevinson%2C+Daphna%3BOno%2C+Yutaka%3BPetukhova%2C+Maria%3BPosada-Villa%2C+Jos%C3%A9%3BSeedat%2C+Soraya%3BWells%2C+J+Elisabeth&rft.aulast=Wang&rft.aufirst=Philip&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=841&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-09-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Methods Psychiatr Res. 2004;13(2):122-39 [15297907] Psychiatr Serv. 1998 Oct;49(10):1273-4, 1290 [9779894] Clin Child Fam Psychol Rev. 1999 Sep;2(3):183-98 [11227074] Arch Gen Psychiatry. 2002 Feb;59(2):115-23 [11825131] Int J Methods Psychiatr Res. 2002;11(3):125-33 [12459825] BMJ. 2003 Mar 29;326(7391):692-5 [12663407] Psychiatr Serv. 2003 Apr;54(4):501-7 [12663837] Health Aff (Millwood). 2003 May-Jun;22(3):122-33 [12757277] Allergy. 2003 Aug;58(8):707-16 [12859546] Health Aff (Millwood). 2003 Sep-Oct;22(5):8-20 [14515877] J Ment Health Policy Econ. 2003 Sep;6(3):135-43 [14646006] J Ment Health Policy Econ. 2003 Sep;6(3):145-7 [14646007] J Ment Health Policy Econ. 2003 Sep;6(3):149-50 [14646008] JAMA. 2004 Jun 2;291(21):2581-90 [15173149] Arch Gen Psychiatry. 2005 Jun;62(6):629-40 [15939840] Int J Methods Psychiatr Res. 2004;13(3):165-75 [15297900] Arch Gen Psychiatry. 1976 Jun;33(6):766-71 [938196] J Health Soc Behav. 1981 Mar;22(1):49-64 [7240706] Med Care. 1985 Dec;23(12):1322-37 [4087948] Med Care. 1986 Jan;24(1):75-85 [3945131] Am J Community Psychol. 1993 Oct;21(5):607-33 [8192124] J Psychiatr Res. 1994 Jan-Feb;28(1):57-84 [8064641] Milbank Q. 1994;72(3):451-70 [7935242] Milbank Q. 1994;72(3):501-14 [7935244] N Engl J Med. 1997 Feb 20;336(8):551-7 [9023093] Schizophr Bull. 1998;24(1):1-10 [9502542] Int J Psychiatry Med. 1997;27(2):93-105 [9565717] Comment In: Issues Ment Health Nurs. 2008;29(2):99-100 [18293218] Lancet. 2007 Sep 8;370(9590):807-8 [17826153] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human papillomavirus and cervical cancer. AN - 68249069; 17826171 AB - Cervical cancer is the second most common cancer in women worldwide, and knowledge regarding its cause and pathogenesis is expanding rapidly. Persistent infection with one of about 15 genotypes of carcinogenic human papillomavirus (HPV) causes almost all cases. There are four major steps in cervical cancer development: infection of metaplastic epithelium at the cervical transformation zone, viral persistence, progression of persistently infected epithelium to cervical precancer, and invasion through the basement membrane of the epithelium. Infection is extremely common in young women in their first decade of sexual activity. Persistent infections and precancer are established, typically within 5-10 years, from less than 10% of new infections. Invasive cancer arises over many years, even decades, in a minority of women with precancer, with a peak or plateau in risk at about 35-55 years of age. Each genotype of HPV acts as an independent infection, with differing carcinogenic risks linked to evolutionary species. Our understanding has led to improved prevention and clinical management strategies, including improved screening tests and vaccines. The new HPV-oriented model of cervical carcinogenesis should gradually replace older morphological models based only on cytology and histology. If applied wisely, HPV-related technology can minimise the incidence of cervical cancer, and the morbidity and mortality it causes, even in low-resource settings. JF - Lancet (London, England) AU - Schiffman, Mark AU - Castle, Philip E AU - Jeronimo, Jose AU - Rodriguez, Ana C AU - Wacholder, Sholom AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. schiffmm@mail.nih.gov Y1 - 2007/09/08/ PY - 2007 DA - 2007 Sep 08 SP - 890 EP - 907 VL - 370 IS - 9590 KW - Papillomavirus Vaccines KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Female KW - Uterine Cervical Neoplasms -- prevention & control KW - Human papillomavirus 16 -- pathogenicity KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- pathology KW - Uterine Cervical Neoplasms -- mortality KW - Papillomavirus Infections -- complications KW - Papillomavirus Vaccines -- therapeutic use KW - Human papillomavirus 16 -- genetics KW - Papillomavirus Vaccines -- adverse effects KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68249069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet+%28London%2C+England%29&rft.atitle=Human+papillomavirus+and+cervical+cancer.&rft.au=Schiffman%2C+Mark%3BCastle%2C+Philip+E%3BJeronimo%2C+Jose%3BRodriguez%2C+Ana+C%3BWacholder%2C+Sholom&rft.aulast=Schiffman&rft.aufirst=Mark&rft.date=2007-09-08&rft.volume=370&rft.issue=9590&rft.spage=890&rft.isbn=&rft.btitle=&rft.title=Lancet+%28London%2C+England%29&rft.issn=1474-547X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-20 N1 - Date created - 2007-09-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Is Reflex Sympathetic Dystrophy (RSD)-Dystonia an Organic Disease? T2 - 1st World Congress on Controversies in Neurology (CONy 2007) AN - 39538873; 4727887 JF - 1st World Congress on Controversies in Neurology (CONy 2007) AU - Hallett, M Y1 - 2007/09/06/ PY - 2007 DA - 2007 Sep 06 KW - Reflex sympathetic dystrophy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39538873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=1st+World+Congress+on+Controversies+in+Neurology+%28CONy+2007%29&rft.atitle=Is+Reflex+Sympathetic+Dystrophy+%28RSD%29-Dystonia+an+Organic+Disease%3F&rft.au=Hallett%2C+M&rft.aulast=Hallett&rft.aufirst=M&rft.date=2007-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=1st+World+Congress+on+Controversies+in+Neurology+%28CONy+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.comtecmed.com/cony/Document.aspx?did=33 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Profiling Enhanced by Post-Translational Modification Peak Pair Analysis. T2 - 2007 Conference on Protein Discovery and Development AN - 39478547; 4662329 JF - 2007 Conference on Protein Discovery and Development AU - Whiteley, Gordon Y1 - 2007/09/06/ PY - 2007 DA - 2007 Sep 06 KW - Proteomics KW - Post-translation KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39478547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Protein+Discovery+and+Development&rft.atitle=Proteomic+Profiling+Enhanced+by+Post-Translational+Modification+Peak+Pair+Analysis.&rft.au=Whiteley%2C+Gordon&rft.aulast=Whiteley&rft.aufirst=Gordon&rft.date=2007-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Protein+Discovery+and+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/conference/userAgenda.aspx?id=92 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein-Protein Interactions: What is the Preferred Way for Proteins to Interact? T2 - 2007 Conference on Protein Discovery and Development AN - 39425560; 4662334 JF - 2007 Conference on Protein Discovery and Development AU - Nussinov, Ruth Y1 - 2007/09/06/ PY - 2007 DA - 2007 Sep 06 KW - Protein interaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39425560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Conference+on+Protein+Discovery+and+Development&rft.atitle=Protein-Protein+Interactions%3A+What+is+the+Preferred+Way+for+Proteins+to+Interact%3F&rft.au=Nussinov%2C+Ruth&rft.aulast=Nussinov&rft.aufirst=Ruth&rft.date=2007-09-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Conference+on+Protein+Discovery+and+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.gtcbio.com/conference/userAgenda.aspx?id=92 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-18 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Declines in Invasive Breast Cancer and Use of Postmenopausal Hormone Therapy in a Screening Mammography Population AN - 220984247; 17698950 AB - Whether a recent large decline in use of postmenopausal hormone therapy after the release of the Women's Health Initiative findings in July 2002 and/or a decline in screening mammography use is related to a recently reported decline in breast cancer incidence in the United States is controversial. We prospectively collected data from four screening mammography registries from January 1997 through December 2003 for 603411 screening mammography examinations performed on women aged 50-69 years. Of these women, 3238 were diagnosed with breast cancer within 12 months of a screening examination. We calculated quarterly rates of self-reported current postmenopausal hormone therapy use and of invasive breast cancer, ductal carcinoma in situ (DCIS), and estrogen receptor (ER)-positive invasive breast cancer adjusted for age, registry, and time between screening examinations. All statistical tests were two-sided. Between 2000 and 2002 and between 2002 and 2003, annual rates of postmenopausal hormone therapy use declined by 7% and 34%, respectively (Ptrend<.001 for both). Between 2000 and 2003, annual rates of invasive cancer declined by 5% (Ptrend =.003). Between 2001 and 2003, annual rates of ER-positive invasive breast cancer declined by 13% (Ptrend=.002). Rates of DCIS were stable during the study period. Our finding of a statistically significant decline in the rate of ER-positive invasive breast cancer in a screening mammography population after the start of a concomitant substantial decline in postmenopausal hormone therapy use suggests that a decline in screening mammography rates is unlikely to account for the recent decline in US breast cancer incidence. [PUBLICATION ABSTRACT] JF - Journal of the National Cancer Institute AU - Kerlikowske, Karla AU - Miglioretti, Diana L AU - Buist, Diana S M AU - Walker, Rod AU - Carney, Patricia A Y1 - 2007/09/05/ PY - 2007 DA - 2007 Sep 05 SP - 1335 EP - 9 CY - Oxford PB - Oxford Publishing Limited(England) VL - 99 IS - 17 SN - 00278874 KW - Medical Sciences--Oncology KW - Breast cancer KW - Hormone replacement therapy KW - Mammography KW - Medical diagnosis KW - Women KW - Middle age KW - Older people KW - United States KW - US KW - Neoplasm Invasiveness KW - Humans KW - Aged KW - Middle Aged KW - Breast Neoplasms -- epidemiology KW - United States -- epidemiology KW - Female KW - Estrogen Replacement Therapy KW - Mass Screening KW - Postmenopause KW - Breast Neoplasms -- pathology KW - Breast Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220984247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Declines+in+Invasive+Breast+Cancer+and+Use+of+Postmenopausal+Hormone+Therapy+in+a+Screening+Mammography+Population&rft.au=Kerlikowske%2C+Karla%3BMiglioretti%2C+Diana+L%3BBuist%2C+Diana+S+M%3BWalker%2C+Rod%3BCarney%2C+Patricia+A&rft.aulast=Kerlikowske&rft.aufirst=Karla&rft.date=2007-09-05&rft.volume=99&rft.issue=17&rft.spage=1335&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/10.1093%2Fjnci%2Fdjm111 LA - English DB - ProQuest Central N1 - Copyright - © The Author 2007. Published by Oxford University Press. N1 - Last updated - 2014-05-17 N1 - CODEN - JNCIEQ N1 - SubjectsTermNotLitGenreText - United States; US DO - http://dx.doi.org/10.1093/jnci/djm111 ER -