TY - JOUR T1 - Representing object colour in language comprehension AN - 85663499; 200801227 AB - Embodied theories of cognition hold that mentally representing something red engages the neural subsystems that respond to environmental perception of that colour. This paper examines whether implicit perceptual information on object colour is represented during sentence comprehension even though doing so does not necessarily facilitate task performance. After reading a sentence that implied a particular colour for a given object, participants were presented with a picture of the object that either matched or mismatched the implied colour. When asked if the pictured object was mentioned in the preceding sentence, people's responses were faster when the colours mismatched than when they matched, suggesting that object colour is represented differently to other object properties such as shape and orientation. A distinction between stable and unstable embodied representations is proposed to allow embodied theories to account for these findings. [Copyright 2006 Elsevier B.V.] JF - Cognition AU - Connell, Louise AD - Cognition & Communication Research Centre, Division of Psychology, Northumbria University, Newcastle upon Tyne, NEI 8ST, UK Tel: + 44 191 227 3446, Fax: +44 191 227 4515 louise.connell@northumbria.ac.uk Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 476 EP - 485 VL - 102 IS - 3 SN - 0010-0277, 0010-0277 KW - Cognitive Processes (12950) KW - Mental Representation (52945) KW - Color (13450) KW - Visual Media (94550) KW - Visual Perception (94600) KW - Comprehension (13950) KW - Brain (09350) KW - Embodiment (21558) KW - Reading Processes (71150) KW - article KW - 4012: psycholinguistics; language and cognition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85663499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cognition&rft.atitle=Representing+object+colour+in+language+comprehension&rft.au=Connell%2C+Louise&rft.aulast=Connell&rft.aufirst=Louise&rft.date=2007-03-01&rft.volume=102&rft.issue=3&rft.spage=476&rft.isbn=&rft.btitle=&rft.title=Cognition&rft.issn=00100277&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2008-02-01 N1 - Last updated - 2016-09-27 N1 - CODEN - CGTNAU N1 - SubjectsTermNotLitGenreText - Color (13450); Embodiment (21558); Cognitive Processes (12950); Mental Representation (52945); Brain (09350); Reading Processes (71150); Visual Perception (94600); Visual Media (94550); Comprehension (13950) ER - TY - JOUR T1 - Benefits of the combination of thalidomide plus cyclophosphamide in hormone refractory prostate cancer patients. AN - 70466019; 17471018 JF - Cancer biology & therapy AU - Al-Chalabi, Tania AU - Figg, William D AD - Molecular Pharmacology Section, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 318 EP - 319 VL - 6 IS - 3 SN - 1538-4047, 1538-4047 KW - Androgens KW - 0 KW - Thalidomide KW - 4Z8R6ORS6L KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Humans KW - Clinical Trials, Phase I as Topic KW - Male KW - Androgens -- metabolism KW - Cyclophosphamide -- administration & dosage KW - Cyclophosphamide -- therapeutic use KW - Thalidomide -- adverse effects KW - Thalidomide -- administration & dosage KW - Thalidomide -- therapeutic use KW - Prostatic Neoplasms -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70466019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Benefits+of+the+combination+of+thalidomide+plus+cyclophosphamide+in+hormone+refractory+prostate+cancer+patients.&rft.au=Al-Chalabi%2C+Tania%3BFigg%2C+William+D&rft.aulast=Al-Chalabi&rft.aufirst=Tania&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-05-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Cancer Biol Ther. 2007 Mar;6(3):313-7 [17327701] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Brain radiotherapy during treatment with anticonvulsant therapy as a trigger for toxic epidermal necrolysis. AN - 70438858; 17465258 AB - Toxic epidermal necrolysis (TEN) is a severe mucocutaneous syndrome that can be occasionally caused by anticonvulsant drugs. In some cases, cranial irradiation may act as a precipitating factor. Thus, in cancer patients who suffer from brain metastases and are administered antiepileptic drugs for seizure prophylaxis, the risk of developing TEN after receiving palliative brain radiotherapy cannot be ignored. We is reported. The case of a young patient with non-small cell lung cancer (NSCLC) treated with prophylactic phenobarbital who developed TEN within a few days of completing cranial radiotherapy for brain metastases is reported. To minimize the risk of TEN in patients undergoing brain radiotherapy, prophylactic anticonvulsant therapy is recommended only after an accurate measurement of the true benefits. Alternatively, discontinuation of antiepileptic treatment before the initiation of brain radiotherapy, or the use of anticonvulsants associated with a lower risk of developing cutaneous reactions might be considered. JF - Anticancer research AU - Metro, Giulio AU - Pino, Simona AU - Pellegrini, Domenica AU - Sacerdoti, Giorgio AU - Fabi, Alessandra AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Rome, Italy. PY - 2007 SP - 1167 EP - 1169 VL - 27 IS - 2 SN - 0250-7005, 0250-7005 KW - Anticonvulsants KW - 0 KW - Index Medicus KW - Humans KW - Adult KW - Male KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology KW - Brain Neoplasms -- radiotherapy KW - Anticonvulsants -- adverse effects KW - Stevens-Johnson Syndrome -- etiology KW - Brain Neoplasms -- secondary KW - Radiation Injuries -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70438858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anticancer+research&rft.atitle=Brain+radiotherapy+during+treatment+with+anticonvulsant+therapy+as+a+trigger+for+toxic+epidermal+necrolysis.&rft.au=Metro%2C+Giulio%3BPino%2C+Simona%3BPellegrini%2C+Domenica%3BSacerdoti%2C+Giorgio%3BFabi%2C+Alessandra&rft.aulast=Metro&rft.aufirst=Giulio&rft.date=2007-03-01&rft.volume=27&rft.issue=2&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-10 N1 - Date created - 2007-04-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Is there a future for quantifying drinking in the diagnosis, treatment, and prevention of alcohol use disorders? AN - 70375469; 17307789 JF - Alcohol and alcoholism (Oxford, Oxfordshire) AU - Li, Ting-Kai AU - Hewitt, Brenda G AU - Grant, Bridget F AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, U.S. Depart-ment of Health and Human Services, Bethesda, MD 20892-9304, USA. PY - 2007 SP - 57 EP - 63 VL - 42 IS - 2 SN - 0735-0414, 0735-0414 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - United States KW - Alcoholism -- rehabilitation KW - Alcoholism -- diagnosis KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Child KW - Cross-Sectional Studies KW - Alcoholism -- epidemiology KW - Health Surveys KW - Adult KW - Ethanol -- toxicity KW - Middle Aged KW - Adolescent KW - Alcoholism -- prevention & control KW - Male KW - Female KW - Alcohol-Related Disorders -- diagnosis KW - Alcohol-Related Disorders -- rehabilitation KW - Alcohol Drinking -- adverse effects KW - Alcohol-Related Disorders -- prevention & control KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70375469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.atitle=Is+there+a+future+for+quantifying+drinking+in+the+diagnosis%2C+treatment%2C+and+prevention+of+alcohol+use+disorders%3F&rft.au=Li%2C+Ting-Kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-03-01&rft.volume=42&rft.issue=2&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+alcoholism+%28Oxford%2C+Oxfordshire%29&rft.issn=07350414&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2007-04-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cumulative lead dose and cognitive function in adults: a review of studies that measured both blood lead and bone lead. AN - 70373308; 17431502 AB - We review empirical evidence for the relations of recent and cumulative lead dose with cognitive function in adults. A systematic search of electronic databases resulted in 21 environmental and occupational studies from 1996 to 2006 that examined and compared associations of recent (in blood) and cumulative (in bone) lead doses with neurobehavioral outcomes. Data were abstracted after consideration of exclusion criteria and quality assessment, and then compiled into summary tables. At exposure levels encountered after environmental exposure, associations with bio-markers of cumulative dose (mainly lead in tibia) were stronger and more consistent than associations with blood lead levels. Similarly, in studies of former workers with past occupational lead exposure, associations were also stronger and more consistent with cumulative dose than with recent dose (in blood). In contrast, studies of currently exposed workers generally found associations that were more apparent with blood lead levels; we speculate that the acute effects of high, recent dose may mask the chronic effects of cumulative dose. There is moderate evidence for an association between psychiatric symptoms and lead dose but only at high levels of current occupational lead exposure or with cumulative dose in environmentally exposed adults. JF - Environmental health perspectives AU - Shih, Regina A AU - Hu, Howard AU - Weisskopf, Marc G AU - Schwartz, Brian S AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 483 EP - 492 VL - 115 IS - 3 SN - 0091-6765, 0091-6765 KW - Environmental Pollutants KW - 0 KW - Lead KW - 2P299V784P KW - Index Medicus KW - Humans KW - Adult KW - Bone and Bones -- metabolism KW - Environmental Pollutants -- toxicity KW - Cognition -- drug effects KW - Lead -- toxicity KW - Environmental Pollutants -- analysis KW - Lead -- analysis KW - Environmental Pollutants -- blood KW - Lead -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70373308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cumulative+lead+dose+and+cognitive+function+in+adults%3A+a+review+of+studies+that+measured+both+blood+lead+and+bone+lead.&rft.au=Shih%2C+Regina+A%3BHu%2C+Howard%3BWeisskopf%2C+Marc+G%3BSchwartz%2C+Brian+S&rft.aulast=Shih&rft.aufirst=Regina&rft.date=2007-03-01&rft.volume=115&rft.issue=3&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-14 N1 - Date created - 2007-04-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Mar;108(3):239-42 [10706530] Gerontology. 2000 Jul-Aug;46(4):219-27 [10859462] Neurotoxicology. 2000 Jun;21(3):365-78 [10894126] Neurology. 2000 Jul 12;55(1):134-6 [10891924] Neurology. 2000 Oct 24;55(8):1144-50 [11071492] Neurotoxicology. 2000 Oct;21(5):805-11 [11130286] Am J Epidemiol. 2001 Mar 1;153(5):453-64 [11226977] Neurotoxicology. 2000 Dec;21(6):1069-80 [11233753] Environ Health Perspect. 2001 Apr;109(4):361-8 [11335184] Toxicol Lett. 2001 Sep 15;123(2-3):195-207 [11641047] Arch Toxicol. 2001 Sep;75(7):439-42 [11693185] Behav Brain Res. 2001 Dec 14;127(1-2):199-207 [11718892] Occup Environ Med. 2002 Apr;59(4):217-23 [11934948] Arch Toxicol. 2002 Apr;76(3):137-45 [11967618] Environ Health Perspect. 2002 May;110(5):501-5 [12003753] Arch Neurol. 2002 May;59(5):787-93 [12020261] Psychol Aging. 2002 Jun;17(2):179-93 [12061405] Int Arch Occup Environ Health. 2002 Aug;75(6):394-8 [12070635] Occup Environ Med. 2002 Sep;59(9):648-9 [12205243] Epidemiology. 2003 Jan;14(1):30-6 [12500043] Occup Environ Med. 2003 Feb;60(2):145; author reply 145-6 [12554847] Ann Neurol. 2003 Feb;53(2):214-21 [12557288] Biol Psychiatry. 2003 Feb 1;53(3):254-60 [12559659] JAMA. 2003 Mar 26;289(12):1523-32 [12672769] Neurobiol Aging. 2003 Nov;24(7):903-7 [12928048] J Clin Exp Neuropsychol. 2003 Sep;25(6):866-77 [13680463] Epidemiology. 2003 Nov;14(6):713-8 [14569188] J Occup Environ Med. 2003 Nov;45(11):1144-51 [14610395] J Psychiatr Res. 1975 Nov;12(3):189-98 [1202204] Arch Gen Psychiatry. 1981 Jan;38(1):42-7 [7458568] N Engl J Med. 1983 Jun 9;308(23):1373-7 [6188954] Acta Psychiatr Scand Suppl. 1983;303:38-48 [6575582] Psychol Med. 1983 Aug;13(3):595-605 [6622612] Med Hypotheses. 1992 Mar;37(3):161-5 [1350050] Science. 1993 Aug 13;261(5123):921-3 [8346443] Lancet. 1993 Sep 18;342(8873):710-1 [8103823] Neurotoxicology. 1994 Summer;15(2):295-307 [7991218] Am J Med Genet. 1994 Sep 15;54(3):199-205 [7810577] Neurology. 1995 Mar;45(3 Pt 1):555-7 [7898715] Occup Environ Med. 1995 Jan;52(1):2-12 [7697135] Annu Rev Pharmacol Toxicol. 1995;35:391-415 [7598500] Occup Environ Med. 1995 Jun;52(6):408-14 [7627319] Environ Health Perspect. 1995 Jan;103(1):78-83 [7628429] J Gerontol B Psychol Sci Soc Sci. 1996 Jan;51(1):P30-42 [8548516] Neuron. 1996 May;16(5):921-32 [8630250] Psychol Rev. 1996 Jul;103(3):403-28 [8759042] Occup Environ Med. 1996 Jul;53(7):472-7 [8704872] Nat Genet. 1996 Sep;14(1):55-61 [8782820] Neurology. 1997 Mar;48(3):639-45 [9065540] Sci Total Environ. 1997 Aug 1;201(1):39-51 [9232024] Neurotoxicology. 1997;18(3):793-803 [9339826] Aging (Milano). 1997 Aug;9(4):241-57 [9359935] Neurotoxicol Teratol. 1998 Jan-Feb;20(1):19-27 [9511166] Occup Environ Med. 1998 Mar;55(3):202-9 [9624272] Brain Res Brain Res Rev. 1998 Jul;27(2):168-76 [9622620] Nat Genet. 1998 Aug;19(4):321-2 [9697689] J Neural Transm Suppl. 1998;53:199-207 [9700658] Environ Health Perspect. 1998 Nov;106(11):745-50 [9799191] Occup Environ Med. 1998 Aug;55(8):507-16 [9849536] Arch Neurol. 1999 Mar;56(3):303-8 [10190820] Neurology. 1999 May 12;52(8):1610-7 [10331686] Neuropsychology. 1999 Oct;13(4):546-56 [10527063] Am J Epidemiol. 2004 Dec 15;160(12):1184-93 [15583371] Epidemiology. 2005 Jan;16(1):106-13 [15613953] Environ Health Perspect. 2005 Jan;113(1):31-5 [15626644] Occup Environ Med. 2005 Mar;62(3):181-7 [15723883] J Am Geriatr Soc. 2005 Mar;53(3):381-8 [15743278] Am J Epidemiol. 2006 Mar 1;163(5):467-78 [16421242] Am J Epidemiol. 2006 Apr 15;163(8):700-8 [16484446] Neurology. 2006 May 23;66(10):1476-84 [16717205] Alzheimer Dis Assoc Disord. 2006 Apr-Jun;20(2):93-100 [16772744] Prog Cardiovasc Dis. 2006 Jul-Aug;49(1):1-10 [16867845] Epidemiology. 2006 Sep;17(5):538-44 [16906055] Neurol Res. 2006 Sep;28(6):605-11 [16945211] Environ Health Perspect. 2006 Oct;114(10):1479-85 [17035129] Neurology. 2006 Nov 14;67(9):1556-62 [16971698] Epidemiology. 2007 Jan;18(1):59-66 [17130688] Environ Health Perspect. 2007 Mar;115(3):455-62 [17431499] Environ Health Perspect. 2007 Mar;115(3):463-71 [17431500] J Neurochem. 1999 Dec;73(6):2613-6 [10582625] Arch Toxicol. 2000 Jan;73(10-11):510-8 [10663381] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence. AN - 70344667; 17407506 AB - Reduced right amygdala volumes have been reported in young, alcohol-naïve subjects at high risk (HR) for alcohol dependence. The differences in brain morphometry have been associated with an excess of externalizing behaviors in these subjects. This may reflect a neurobiological vulnerability to alcohol dependence. Existing Magnetic Resonance Imaging (MRI) studies on these subjects have examined only a few, pre-selected brain regions using the manual regions of interest (ROI) approach. MRI of HR subjects (n = 20) and age, sex, and handedness-matched low-risk (LR) subjects (n = 21) were analyzed using optimized voxel-based morphometry and ROI approach. The externalizing symptoms of these subjects and their fathers were measured using the Semi-Structured Assessment for the Genetics of Alcoholism. HR subjects had significantly smaller volumes of superior frontal, cingulate and parahippocampal gyri, amygdala, thalamus and cerebellum. These gray matter volumes correlated negatively with externalizing symptoms scores. Subjects at HR for alcoholism have reduced volumes of critical areas of brain gray matter, which are associated with increased externalizing symptoms. These represent key endophenotypes of alcoholism. JF - Addiction biology AU - Benegal, Vivek AU - Antony, George AU - Venkatasubramanian, Ganesan AU - Jayakumar, Peruvumba N AD - Department of Psychiatry, National Institute of Mental Health & Neurosciences, Bangalore, India. vbenegal@gmail.com Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 122 EP - 132 VL - 12 IS - 1 SN - 1355-6215, 1355-6215 KW - Index Medicus KW - Age Factors KW - Dominance, Cerebral -- physiology KW - Reference Values KW - Humans KW - Child KW - Amygdala -- pathology KW - Risk KW - Prefrontal Cortex -- pathology KW - Adult KW - Caudate Nucleus -- pathology KW - Statistics as Topic KW - Hippocampus -- pathology KW - Adolescent KW - Male KW - Magnetic Resonance Imaging KW - Attention Deficit Disorder with Hyperactivity -- psychology KW - Attention Deficit and Disruptive Behavior Disorders -- psychology KW - Attention Deficit Disorder with Hyperactivity -- genetics KW - Internal-External Control KW - Brain -- pathology KW - Conduct Disorder -- genetics KW - Conduct Disorder -- psychology KW - Alcoholism -- genetics KW - Image Processing, Computer-Assisted KW - Attention Deficit and Disruptive Behavior Disorders -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70344667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Gray+matter+volume+abnormalities+and+externalizing+symptoms+in+subjects+at+high+risk+for+alcohol+dependence.&rft.au=Benegal%2C+Vivek%3BAntony%2C+George%3BVenkatasubramanian%2C+Ganesan%3BJayakumar%2C+Peruvumba+N&rft.aulast=Benegal&rft.aufirst=Vivek&rft.date=2007-03-01&rft.volume=12&rft.issue=1&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Region-specific down-regulation of Crhr1 gene expression in alcohol-preferring msP rats following ad lib access to alcohol. AN - 70344503; 17407495 AB - Corticotropin-releasing hormone 1 receptors (CRH-R1) mediate increased behavioral sensitivity to stress and excessive alcohol self-administration following a history of dependence. It was recently demonstrated that the genetically selected alcohol-preferring msP rat line replicates many characteristics of the post-dependent state, due to an innate up-regulation of the Crhr1 transcript in several limbic areas related to alcohol drinking motivation. Here, we examined whether voluntary alcohol consumption might be able to down-regulate Crhr1 transcript levels in msP rats in brain areas where elevated expression previously has been shown. Within central and medial amygdala (CeA, MeA), as well as the Nc. Accumbens, 2 weeks'ad lib access to alcohol led to a highly significant down-regulation of the Crhr1 transcript. Alcohol-induced Crhr1 down-regulation was not seen in cingulate cortex. These data support that recruitment of CRH-R1 signaling within components of the extended amygdala drives excessive alcohol intake, and that alcohol is voluntarily consumed in part for its ability to reduce CRH-R1 activity in this region. JF - Addiction biology AU - Hansson, Anita C AU - Cippitelli, Andrea AU - Sommer, Wolfgang H AU - Ciccocioppo, Roberto AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, NIAAA/NIH, Bethesda, MD 20892-1108, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 30 EP - 34 VL - 12 IS - 1 SN - 1355-6215, 1355-6215 KW - CRF receptor type 1 KW - 0 KW - Receptors, Corticotropin-Releasing Hormone KW - Index Medicus KW - Rats, Inbred Strains KW - Rats KW - Animals KW - In Situ Hybridization KW - Down-Regulation -- genetics KW - Gyrus Cinguli -- metabolism KW - Male KW - Amygdala -- metabolism KW - Nucleus Accumbens -- metabolism KW - Receptors, Corticotropin-Releasing Hormone -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70344503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Region-specific+down-regulation+of+Crhr1+gene+expression+in+alcohol-preferring+msP+rats+following+ad+lib+access+to+alcohol.&rft.au=Hansson%2C+Anita+C%3BCippitelli%2C+Andrea%3BSommer%2C+Wolfgang+H%3BCiccocioppo%2C+Roberto%3BHeilig%2C+Markus&rft.aulast=Hansson&rft.aufirst=Anita&rft.date=2007-03-01&rft.volume=12&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemical genetic screening identifies critical pathways in anthrax lethal toxin-induced pathogenesis. AN - 70306742; 17379140 AB - Anthrax lethal toxin (LT)-induced cell death via mitogen-activated protein kinase kinase (MAPKK) cleavage remains questionable. Here, a chemical genetics approach was used to investigate what pathways mediate LT-induced cell death. Several small molecules were found to protect macrophages from anthrax LT cytotoxicity and MAPKK from cleavage by lethal factor (LF), without inhibiting LF enzymatic activity or cellular proteasome activity. Interestingly, the compounds activated MAPK-signaling molecules, induced proinflammatory cytokine production, and inhibited LT-induced macrophage apoptosis in a concentration-dependent manner. We propose that induction of antiapoptotic responses by MAPK-dependent or -independent pathways and activation of host innate responses may protect macrophages from anthrax LT-induced cell death. Altering host responses through a chemical genetics approach can help identify critical cellular pathways involved in the pathogenesis of anthrax and can be exploited to further explore host-pathogen interactions. JF - Chemistry & biology AU - Panchal, Rekha G AU - Ruthel, Gordon AU - Brittingham, Katherine C AU - Lane, Douglas AU - Kenny, Tara A AU - Gussio, Rick AU - Lazo, John S AU - Bavari, Sina AD - Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA. rekha.panchal@amedd.army.mil Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 245 EP - 255 VL - 14 IS - 3 SN - 1074-5521, 1074-5521 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Cell Cycle Proteins KW - Cytokines KW - anthrax toxin KW - Mitogen-Activated Protein Kinase Kinases KW - EC 2.7.12.2 KW - cdc25 Phosphatases KW - EC 3.1.3.48 KW - Index Medicus KW - Macrophages -- cytology KW - Microscopy, Confocal KW - Animals KW - Cell Cycle Proteins -- antagonists & inhibitors KW - Genetic Testing -- methods KW - Macrophages -- physiology KW - cdc25 Phosphatases -- antagonists & inhibitors KW - Cytokines -- metabolism KW - Mice KW - Cell Death -- drug effects KW - Macrophages -- drug effects KW - Necrosis KW - Apoptosis -- drug effects KW - Cell Line KW - Antigens, Bacterial -- toxicity KW - Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors KW - Bacterial Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70306742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemistry+%26+biology&rft.atitle=Chemical+genetic+screening+identifies+critical+pathways+in+anthrax+lethal+toxin-induced+pathogenesis.&rft.au=Panchal%2C+Rekha+G%3BRuthel%2C+Gordon%3BBrittingham%2C+Katherine+C%3BLane%2C+Douglas%3BKenny%2C+Tara+A%3BGussio%2C+Rick%3BLazo%2C+John+S%3BBavari%2C+Sina&rft.aulast=Panchal&rft.aufirst=Rekha&rft.date=2007-03-01&rft.volume=14&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Chemistry+%26+biology&rft.issn=10745521&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-11 N1 - Date created - 2007-03-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The importance of carcinogen dose in chemoprevention studies: quantitative interrelationships between, dibenzo[a,l]pyrene dose, chlorophyllin dose, target organ DNA adduct biomarkers and final tumor outcome. AN - 70290828; 16973675 AB - Chlorophyllin (CHL) is a potent antimutagen in vitro, an effective anti-carcinogen in several animal models, and significantly reduced urinary biomarkers of aflatoxin B(1) (AFB(1)) exposure in a human population. Here we report an expanded analysis of CHL chemoprevention using the potent environmental hydrocarbon dibenzo[a,l]pyrene (DBP). A dose-dose matrix design employed over 12 000 rainbow trout to evaluate the interrelationships among dietary carcinogen dose, anti-carcinogen dose, carcinogen-DNA adduct levels at exposure and eventual tumor outcome in two target organs. Included was an evaluation of the pharmaceutical CHL preparation (Derifil), used previously in a study of individuals chronically exposed to AFB(1). CHL was pre-, co- and post-fed at doses of 0-6000 p.p.m. and co-fed with DBP at doses of 0-371.5 p.p.m. for 4 weeks. This protocol generated a total of 21 dose-dose treatment groups, each evaluated with three or more replicates of 100 animals. The DBP-only treatment produced dose-responsive increases in liver and stomach DBP-DNA adducts, whereas increasing CHL co-treatment doses produced successive inhibition in liver (49-83%) and stomach (47-75%) adduct levels at each DBP dose examined. The remaining 8711 trout were necropsied, 10 months later. DBP treatment alone produced a logit incidence versus log [DBP] dose-response curve in stomach that was linear; CHL co-treatment provided dose-dependent tumor inhibition which ranged from 30 to 68% and was predictable from the adduct response. The Derifil CHL preparation was also found to effectively reduce DNA adduction and final tumor incidence in stomach (as well as liver), with a potency compatible with its total chlorin content. Liver tumor incidence in the DBP-only groups appeared to plateau near 60%. At DBP doses of A polymorphism [TA genotype: odds ratio (OR)=1.32, 95% confidence interval (CI)=0.86-2.02; AA, OR=1.84, 95% CI=1.10-3.08; trend test, P=0.02]. Our most noteworthy TNF finding was an association between -857C>T and a decreased risk of NHL (CT or TT, OR=0.59, 95% CI=0.42-0.84, P=0.003) and particularly follicular lymphoma (OR=0.40, 95% CI=0.23-0.68, P=0.0009). Additionally, TNF -863C>A was associated with an elevated risk of DLBCL (CA, OR=1.45, 95% CI=0.95-2.21; AA, OR=2.06, 95% CI=0.88-4.83; trend test, P=0.02). Our findings offer further evidence that variation in the IL10 and TNF loci influences NHL risk. Additional studies are needed to clarify the genetic and biologic basis for these relationships. JF - Carcinogenesis AU - Purdue, Mark P AU - Lan, Qing AU - Kricker, Anne AU - Grulich, Andrew E AU - Vajdic, Claire M AU - Turner, Jennifer AU - Whitby, Denise AU - Chanock, Stephen AU - Rothman, Nathaniel AU - Armstrong, Bruce K AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892-7240, USA. purduem@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 704 EP - 712 VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Interleukins KW - 0 KW - Lymphotoxin-alpha KW - Receptors, Cell Surface KW - Receptors, Leptin KW - Tumor Necrosis Factor-alpha KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Lymphotoxin-alpha -- genetics KW - Humans KW - Lymphoma, B-Cell -- epidemiology KW - Aged KW - Lymphoma, B-Cell -- genetics KW - Chromosome Mapping KW - Registries KW - Lymphoma, B-Cell -- immunology KW - Risk Factors KW - Adult KW - Middle Aged KW - Receptors, Cell Surface -- genetics KW - New South Wales -- epidemiology KW - Amino Acid Substitution KW - Female KW - Male KW - Lymphoma, Non-Hodgkin -- genetics KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Polymorphism, Genetic KW - Lymphoma, Non-Hodgkin -- immunology KW - Tumor Necrosis Factor-alpha -- genetics KW - Interleukins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70285731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+immune+function+genes+and+risk+of+non-Hodgkin+lymphoma%3A+findings+from+the+New+South+Wales+non-Hodgkin+Lymphoma+Study.&rft.au=Purdue%2C+Mark+P%3BLan%2C+Qing%3BKricker%2C+Anne%3BGrulich%2C+Andrew+E%3BVajdic%2C+Claire+M%3BTurner%2C+Jennifer%3BWhitby%2C+Denise%3BChanock%2C+Stephen%3BRothman%2C+Nathaniel%3BArmstrong%2C+Bruce+K&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=704&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-14 N1 - Date created - 2007-03-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental and behavioral factors and the risk of non-Hodgkin lymphoma. AN - 70282759; 17344463 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Hartge, Patricia AU - Smith, Martyn T AD - National Cancer Institute, NIH, Department of Health and Human Services, Rockville, MD 20892, USA. hartge@nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 367 EP - 368 VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Hazardous Substances KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Epidemiologic Studies KW - Sunlight -- adverse effects KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - Occupations KW - Life Style KW - Environment KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lymphoma, Non-Hodgkin -- etiology KW - Lymphoma, Non-Hodgkin -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Environmental+and+behavioral+factors+and+the+risk+of+non-Hodgkin+lymphoma.&rft.au=Hartge%2C+Patricia%3BSmith%2C+Martyn+T&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A comprehensive investigation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) metabolism in the mouse using a multivariate data analysis approach. AN - 70282476; 17279779 AB - 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a potent rodent carcinogen and a potential human carcinogen because of its existence in the normal human diet. N2-OH-PhIP, a major PhIP metabolite, has been identified as a precursor of genotoxic species. In vitro data supported the view that CYP1A2 is the major enzyme responsible for the formation of N2-OH-PhIP. However, disruption of the CYP1A2 gene in mouse failed to inhibit PhIP-induced carcinogenesis. To investigate the mechanism underlying this observation, the metabolism of PhIP in wild-type, Cyp1a2-null, and CYP1A2-humanized mice was examined in detail using a metabolomic approach. Following data acquisition in a high-resolution LC-MS system, urinary metabolomes of the control and PhIP-treated mice were characterized in a principal component analysis (PCA) model. Comprehensive metabolite profiles of PhIP in high dose (10 mg/kg) and low dose (100 microg/kg) were established through analyzing urinary ions contributing to the separation of three mouse lines in the multivariate model and by measuring radiolabled PhIP metabolite in a radio-HPLC assay, respectively. The genotoxicity of PhIP to three mouse lines was evaluated by measuring DNA adduction levels in liver, lung, colon, and mammary gland. On the basis of the chemical identities of 17 urinary PhIP metabolites, including eight novel metabolites, multivariate data analysis revealed the role of CYP1A2 in PhIP metabolism and a human-mouse interspecies difference in the catalytic activity of CYP1A2. In addition, the results also showed that Cyp1a2-null mice still possess significant N2-hydroxylation and DNA adduction activities, which may be partially attributed to mouse CYP2C enzymes according to the results from in vitro microsome and Supersome incubations and antibody inhibition experiments. JF - Chemical research in toxicology AU - Chen, Chi AU - Ma, Xiaochao AU - Malfatti, Michael A AU - Krausz, Kristopher W AU - Kimura, Shioko AU - Felton, James S AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 531 EP - 542 VL - 20 IS - 3 SN - 0893-228X, 0893-228X KW - Carcinogens KW - 0 KW - DNA Adducts KW - Imidazoles KW - Indicators and Reagents KW - Isoenzymes KW - DNA KW - 9007-49-2 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Cytochrome P-450 CYP1A2 KW - EC 1.14.14.1 KW - Index Medicus KW - DNA Adducts -- genetics KW - Animals KW - Microsomes, Liver -- metabolism KW - Humans KW - Principal Component Analysis KW - Cytochrome P-450 CYP1A2 -- metabolism KW - Mice KW - Tissue Distribution KW - DNA -- biosynthesis KW - Biotransformation -- physiology KW - Isoenzymes -- metabolism KW - Multivariate Analysis KW - Mice, Knockout KW - Cytochrome P-450 CYP1A2 -- genetics KW - DNA -- genetics KW - Microsomes, Liver -- drug effects KW - Carcinogens -- metabolism KW - Imidazoles -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70282476?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=A+comprehensive+investigation+of+2-amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5Dpyridine+%28PhIP%29+metabolism+in+the+mouse+using+a+multivariate+data+analysis+approach.&rft.au=Chen%2C+Chi%3BMa%2C+Xiaochao%3BMalfatti%2C+Michael+A%3BKrausz%2C+Kristopher+W%3BKimura%2C+Shioko%3BFelton%2C+James+S%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2007-03-01&rft.volume=20&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-21 N1 - Date created - 2007-03-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drug Metab Dispos. 2003 May;31(5):548-58 [12695342] Rapid Commun Mass Spectrom. 2005;19(18):2659-70 [16124034] Rapid Commun Mass Spectrom. 2003;17(23):2632-8 [14648901] Drug Metab Rev. 2003 Nov;35(4):319-35 [14705864] Mol Pharmacol. 2004 May;65(5):1148-58 [15102943] Pharmacogenetics. 2004 Jan;14(1):1-18 [15128046] Cancer Res. 1982 May;42(5):1798-808 [6175397] Carcinogenesis. 1990 Mar;11(3):489-92 [2311193] Jpn J Cancer Res. 1989 Dec;80(12):1176-8 [2516847] Carcinogenesis. 1991 Apr;12(4):713-7 [2013135] Carcinogenesis. 1991 Aug;12(8):1417-22 [1907222] Chem Res Toxicol. 1993 Nov-Dec;6(6):846-51 [8117924] Carcinogenesis. 1994 Aug;15(8):1695-701 [8055651] Carcinogenesis. 1994 Nov;15(11):2547-52 [7955104] Chem Res Toxicol. 2005 Sep;18(9):1471-8 [16167840] Carcinogenesis. 2005 Nov;26(11):2019-28 [15944213] Mol Pharmacol. 2006 Apr;69(4):1103-14 [16377763] Philos Trans R Soc Lond B Biol Sci. 2006 Jan 29;361(1465):147-61 [16553314] Chem Res Toxicol. 2006 Jun;19(6):818-27 [16780361] J Pharmacol Exp Ther. 2006 Sep;318(3):1330-42 [16775196] Drug Metab Dispos. 2006 Oct;34(10):1722-33 [16815965] Carcinogenesis. 2007 Mar;28(3):732-7 [17052995] Biochem Pharmacol. 1989 Sep 15;38(18):3067-74 [2783161] Xenobiotica. 1999 Nov;29(11):1181-9 [10598751] Carcinogenesis. 2000 Jun;21(6):1197-203 [10837010] Carcinogenesis. 2001 Jul;22(7):1087-93 [11408353] J Pharmacol Exp Ther. 2001 Oct;299(1):39-47 [11561061] Carcinogenesis. 2002 Jan;23(1):115-22 [11756232] Food Chem Toxicol. 2002 Aug;40(8):1125-30 [12067574] Drug Metab Rev. 2002 Aug;34(3):625-50 [12214671] J Pharmacol Exp Ther. 2003 Apr;305(1):315-22 [12649384] Carcinogenesis. 2003 Mar;24(3):583-7 [12663521] Proc Natl Acad Sci U S A. 1995 May 23;92(11):5134-8 [7761462] Pharmacogenetics. 1996 Aug;6(4):291-6 [8873215] Mutat Res. 1997 May 12;376(1-2):107-14 [9202745] Mutat Res. 1997 May 12;376(1-2):203-10 [9202757] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):1977-82 [10051580] Carcinogenesis. 1999 Sep;20(9):1825-30 [10469630] Cancer Lett. 1999 Sep 1;143(2):109-12 [10503887] Drug Metab Dispos. 2005 Mar;33(3):449-57 [15576447] J Natl Cancer Inst. 2003 Aug 20;95(16):1227-37 [12928348] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The FMR1 premutation and reproduction. AN - 70272082; 17074338 AB - To update clinicians on the reproductive implications of premutations in FMR1 (fragile X mental retardation 1). Fragile X syndrome, a cause of mental retardation and autism, is due to a full mutation (>200 CGG repeats). Initially, individuals who carried the premutation (defined as more than 55 but less than 200 CGG repeats) were not considered at risk for any clinical disorders. It is now recognized that this was incorrect, specifically with respect to female reproduction. Literature review and consensus building at two multidisciplinary scientific workshops. Convincing evidence now relates the FMR1 premutation to altered ovarian function and loss of fertility. An FMR1 mRNA gain-of-function toxicity may underlie this altered ovarian function. There are major gaps in knowledge regarding the natural history of the altered ovarian function in women who carry the FMR1 premutation, making counseling about reproductive plans a challenge. Women with premature ovarian failure are at increased risk of having an FMR1 premutation and should be informed of the availability of fragile X testing. Specialists in reproductive medicine can provide a supportive environment in which to explain the implications of FMR1 premutation testing, facilitate access to testing, and make appropriate referral to genetic counselors. JF - Fertility and sterility AU - Wittenberger, Michael D AU - Hagerman, Randi J AU - Sherman, Stephanie L AU - McConkie-Rosell, Allyn AU - Welt, Corrine K AU - Rebar, Robert W AU - Corrigan, Emily C AU - Simpson, Joe Leigh AU - Nelson, Lawrence M AD - Intramural Research Program, Section on Women's Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1103, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 456 EP - 465 VL - 87 IS - 3 KW - FMR1 protein, human KW - 0 KW - Fragile X Mental Retardation Protein KW - 139135-51-6 KW - Index Medicus KW - Genetic Testing KW - Humans KW - Adult KW - Adolescent KW - Trinucleotide Repeat Expansion KW - Genetic Counseling KW - Preimplantation Diagnosis KW - Male KW - Female KW - Pregnancy KW - Fragile X Syndrome -- therapy KW - Fragile X Syndrome -- genetics KW - Primary Ovarian Insufficiency -- etiology KW - Fragile X Syndrome -- physiopathology KW - Fragile X Mental Retardation Protein -- genetics KW - Primary Ovarian Insufficiency -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272082?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Maternal+seafood+consumption+in+pregnancy+and+neurodevelopmental+outcomes+in+childhood+%28ALSPAC+study%29%3A+an+observational+cohort+study&rft.au=Hibbeln%2C+J+R%3BDavis%2C+J+M%3BSteer%2C+C%3BEmmett%2C+P%3BRogers%2C+I%3BWilliams%2C+C%3BGolding%2C+J&rft.aulast=Hibbeln&rft.aufirst=J&rft.date=2007-02-23&rft.volume=369&rft.issue=9561&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-30 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Fertil Steril. 2007 Nov;88(5):1477; author reply 1477 [17991519] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of tobacco deprivation on the attentional blink in rapid serial visual presentation. AN - 70249880; 17266171 AB - When two targets are imbedded in rapid serial visual presentation (RSVP), identification of the second target (T2) is impaired if it occurs within 500 ms of the first target (T1). This attentional blink (AB) is thought to involve interference of resources in processing T1 and T2. The deleterious effect of tobacco deprivation on attention has been documented, but no studies have examined the AB. Nonsmokers (n=30), 12-h tobacco-deprived smokers (n=30), and nondeprived smokers (n=30) were randomly assigned to perform the RSVP with one of three stimulus-duration conditions (96, 113, or 130 ms). Participants completed 48 RSVP trials. Each trial consisted of 16 individually presented words (T1, T2, and 14 distractors), and T2 lagged T1 at serial positions 1-8. Participants verbalized T1 and T2 in order immediately after each trial. Identification of T2 (for correct T1 trials) was impaired at early versus late lag positions, which was especially pronounced in the most difficult (96 ms) condition. There was no evidence for group differences on the AB; however, deprived smokers were worse identifying T1 in the 113-ms condition. These results suggest that the AB is influenced by stimulus duration, but not by 12 h of tobacco deprivation. Copyright (c) 2007 John Wiley & Sons, Ltd. JF - Human psychopharmacology AU - Heinz, Adrienne AU - Waters, Andrew J AU - Taylor, Richard C AU - Myers, Carol S AU - Moolchan, Eric T AU - Heishman, Stephen J AD - Clinical Pharmacology and Therapeutics Branch, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 89 EP - 96 VL - 22 IS - 2 SN - 0885-6222, 0885-6222 KW - Index Medicus KW - Tobacco Use Disorder -- physiopathology KW - Humans KW - Pattern Recognition, Visual -- physiology KW - Smoking -- psychology KW - Photic Stimulation -- methods KW - Visual Perception -- physiology KW - Smoking -- physiopathology KW - Adult KW - Tobacco Use Disorder -- psychology KW - Middle Aged KW - Adolescent KW - Time Factors KW - Female KW - Male KW - Reaction Time KW - Substance Withdrawal Syndrome -- physiopathology KW - Smoking Cessation KW - Attention -- physiology KW - Substance Withdrawal Syndrome -- psychology KW - Blinking -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70249880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+psychopharmacology&rft.atitle=Effect+of+tobacco+deprivation+on+the+attentional+blink+in+rapid+serial+visual+presentation.&rft.au=Heinz%2C+Adrienne%3BWaters%2C+Andrew+J%3BTaylor%2C+Richard+C%3BMyers%2C+Carol+S%3BMoolchan%2C+Eric+T%3BHeishman%2C+Stephen+J&rft.aulast=Heinz&rft.aufirst=Adrienne&rft.date=2007-03-01&rft.volume=22&rft.issue=2&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Human+psychopharmacology&rft.issn=08856222&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-05 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome. AN - 70246690; 17346546 AB - Prenatal alcohol exposure affects 1 in 100 births in the United States and results in craniofacial dysmorphologic condition and learning disabilities. In a model for fetal alcohol syndrome, neuroprotective peptides prevented fetal death and learning deficits. The gamma-aminobutyric acid A (GABA) receptor subunit GABAbeta3 plays a critical role for nervous system and palate development. Our objective was to determine whether the neuropeptides prevented alcohol-induced damage through GABAbeta3. With a model for fetal alcohol syndrome, timed pregnant C57B16/J mice were treated on gestational day 8 with alcohol (25% alcohol) or control (saline solution) or alcohol plus peptides NAPVSIPQ + SALLRSIPA (NAP + SAL; 20 microg). Embryos were harvested at 6 and 24 hours and 10 days after treatment. Adult males were tested for learning on the Morris water maze, and their brains were dissected. With samples from at least 3 litters per time point, calibrator-normalized relative real-time polymerase chain reaction was performed for GABAbeta3 with glyceraldehyde-3-phosphate dehydrogenase standardization. Statistical analysis included analysis of variance and Fisher protected least significant difference. Twenty-four hours and 10 days after treatment, alcohol decreased GABAbeta3 in the embryos (P < or = .01); this decrease was prevented by the peptides (P = .01). GABAbeta3 was higher in alcohol treated adult brains respect to the controls (P = .002); this rise was not prevented by the peptides. Treatment with the neuropeptides NAPVSIPQ and SALLRSIPA prevented the alcohol-induced decline in GABAbeta3 expression 10 days after alcohol exposure. Because palate formation continues through E18, NAPVSIPQ and SALLRSIPA may be beneficial for the prevention of cleft lip and palate. JF - American journal of obstetrics and gynecology AU - Toso, Laura AU - Roberson, Robin AU - Abebe, Daniel AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. tosol@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 259.e1 EP - 5 VL - 196 IS - 3 KW - GABRB3 protein, human KW - 0 KW - Gabrb3 protein, mouse KW - Oligopeptides KW - Receptors, GABA-A KW - seryl-alanyl-leucy-leucyl-arginyl-seryl-isoleucyl-prolyl-alanine KW - Ethanol KW - 3K9958V90M KW - davunetide KW - GF00K3IIWE KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Mice, Inbred C57BL KW - Mice KW - Female KW - Pregnancy KW - Ethanol -- adverse effects KW - Cleft Palate -- chemically induced KW - Receptors, GABA-A -- physiology KW - Ethanol -- antagonists & inhibitors KW - Receptors, GABA-A -- drug effects KW - Oligopeptides -- pharmacology KW - Learning Disorders -- chemically induced KW - Fetal Alcohol Spectrum Disorders -- etiology KW - Cleft Lip -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70246690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Directed+Cell-Cell+Interactions+in+the+Development+of+Adaptive+Immunity&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of a functional polymorphism in the mu-opioid receptor gene with alcohol response and consumption in male rhesus macaques. AN - 70238520; 17339526 AB - Innate differences in opioid neurotransmission are hypothesized to influence abuse liability of alcohol. In humans, a variant of the mu-opioid receptor gene (OPRM1A118G) increases receptor affinity, alcohol-induced euphoria, and risk for alcohol use disorders. To determine whether a variant in the mu-opioid receptor gene (OPRM1C77G) that increases affinity of the receptor is associated with alcohol response and consumption in macaques. Young adult rhesus macaques (Macaca mulatta) were intravenously administered 2.0 to 2.1 g of ethanol per kilogram of body weight and assessed for alcohol response. Animals were later given simultaneous access to an aspartame-sweetened 8.4% (vol/vol) ethanol solution and a vehicle for 1 hour per day, 5 days a week, for a period of 6 weeks. Animals (N = 82) were genotyped for the OPRM1C77G polymorphism; the effects of the genotype on alcohol response and consumption were determined by analysis of variance, with sex included as a nominal independent variable. Alcohol response (ataxia, stimulation, and sedation), average alcohol consumption, the percentage of days during which an animal consumed alcohol at a level sufficient to produce intoxication (> or =0.67 g of alcohol per kilogram of body weight), and alcohol preference (calculated as 100 x {alcoholic solution/[alcoholic solution + nonalcoholic solution]}). Increased alcohol-induced stimulation was observed among male macaques carrying the OPRM1C77G allele. OPRM1C77G allele carriers consumed more ethanol and exhibited increased ethanol preference. Male carriers of the OPRM1C77G allele exhibited higher alcohol preference and consumption, and drank to intoxication more frequently than did C/C males. These findings demonstrate that the rhesus macaques' equivalent of the OPRM1A118G variant is associated with increased alcohol response, consumption, and preference. Our results reveal effects of the OPRM1C77G genotype to be male-restricted or more marked among male macaques. This is of interest, given the fact that early-onset type II alcoholism is more common among men and that, among addicted individuals, men are more responsive to mu-opioid receptor blockade. JF - Archives of general psychiatry AU - Barr, Christina S AU - Schwandt, Melanie AU - Lindell, Stephen G AU - Chen, Scott A AU - Goldman, David AU - Suomi, Stephen J AU - Higley, J Dee AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Poolesville, MD 20837, USA. cbarr@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 369 EP - 376 VL - 64 IS - 3 SN - 0003-990X, 0003-990X KW - Receptors, Opioid, mu KW - 0 KW - Ethanol KW - 3K9958V90M KW - Abridged Index Medicus KW - Index Medicus KW - Genotype KW - Conditioning, Operant -- drug effects KW - Drinking Behavior -- drug effects KW - Animals KW - Sex Factors KW - Alcoholism -- epidemiology KW - Age of Onset KW - Conditioning, Operant -- physiology KW - Drinking Behavior -- physiology KW - Disease Models, Animal KW - Genetic Variation -- genetics KW - Male KW - Behavior, Animal -- drug effects KW - Ethanol -- pharmacology KW - Polymorphism, Genetic -- genetics KW - Macaca mulatta -- genetics KW - Behavior, Animal -- physiology KW - Alcohol Drinking -- genetics KW - Receptors, Opioid, mu -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70238520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Association+of+a+functional+polymorphism+in+the+mu-opioid+receptor+gene+with+alcohol+response+and+consumption+in+male+rhesus+macaques.&rft.au=Barr%2C+Christina+S%3BSchwandt%2C+Melanie%3BLindell%2C+Stephen+G%3BChen%2C+Scott+A%3BGoldman%2C+David%3BSuomi%2C+Stephen+J%3BHigley%2C+J+Dee%3BHeilig%2C+Markus&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2007-03-01&rft.volume=64&rft.issue=3&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-08 N1 - Date created - 2007-03-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mesothelin expression in human lung cancer. AN - 70226107; 17332303 AB - To investigate mesothelin as a new target for immunotherapy in lung cancer. Mesothelin mRNA and protein expression were assessed by reverse transcription-PCR, immunoblotting, and immunohistochemistry in human lung cancer specimens. Expression was also characterized in human lung cancer cell lines by flow cytometry and immunoblotting. The SS1P immunotoxin specific for mesothelin was assessed for its cytotoxic activity against lung cancer cells. We found that mesothelin mRNA was expressed in 83% of lung adenocarcinomas (10 of 12 patients). The mesothelin precursor protein was detected in 82% of lung adenocarcinoma (9 of 11 patients), and its mature form was detected in 55% (6 of 11 patients). Immunohistochemistry showed strong and diffuse mesothelin staining in human lung adenocarcinomas and weak or modest staining in squamous cell carcinomas. We detected mesothelin mRNA in 78% of lung cancer cell lines (7 of 9) of the NCI-60 cell line panel. Mesothelin mRNA and proteins were expressed at a high level in non-small cell lung cancer lines EKVX, NCI-H460, NCI-H322M, and NCI-H522. Flow cytometric analysis showed high surface expression of mesothelin in NCI-H322M and EKVX cell lines. Immunotoxin SS1P showed high cytotoxic activity on NCI-H322M and EKVX cells with IC(50) values ranging from 2 to 5 ng/mL. Mesothelin is expressed on the surface of most lung adenocarcinoma cells. Immunotoxin SS1P is cytotoxic against mesothelin-expressing lung cancer cell lines and merits evaluation as a new therapeutic agent in treating non-small cell lung cancer. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Ho, Mitchell AU - Bera, Tapan K AU - Willingham, Mark C AU - Onda, Masanori AU - Hassan, Raffit AU - FitzGerald, David AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 1571 EP - 1575 VL - 13 IS - 5 SN - 1078-0432, 1078-0432 KW - Antibodies, Monoclonal KW - 0 KW - GPI-Linked Proteins KW - Membrane Glycoproteins KW - RNA, Messenger KW - SS1(dsFv)PE38 KW - mesothelin KW - Index Medicus KW - Blotting, Western KW - Humans KW - RNA, Messenger -- analysis KW - Flow Cytometry KW - Cell Line, Tumor KW - Antibodies, Monoclonal -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - Immunohistochemistry KW - Membrane Glycoproteins -- drug effects KW - Adenocarcinoma -- metabolism KW - Membrane Glycoproteins -- biosynthesis KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70226107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Mesothelin+expression+in+human+lung+cancer.&rft.au=Ho%2C+Mitchell%3BBera%2C+Tapan+K%3BWillingham%2C+Mark+C%3BOnda%2C+Masanori%3BHassan%2C+Raffit%3BFitzGerald%2C+David%3BPastan%2C+Ira&rft.aulast=Ho&rft.aufirst=Mitchell&rft.date=2007-03-01&rft.volume=13&rft.issue=5&rft.spage=1571&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-09 N1 - Date created - 2007-03-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclooxygenase-2 inhibits UVB-induced apoptosis in mouse skin by activating the prostaglandin E2 receptors, EP2 and EP4. AN - 70224314; 17332329 AB - Cyclooxygenase-2 (COX-2) is induced by UVB light and reduces UVB-induced epidermal apoptosis; however, the mechanism is unclear. Therefore, wild-type (WT) and COX-2-/- mice were acutely treated with UVB (5 kJ/m(2)), and apoptotic signaling pathways were compared. Following exposure, apoptosis was 2.5-fold higher in COX-2-/- compared with WT mice. Because prostaglandin E(2) (PGE(2)) is the major UV-induced prostaglandin and manifests its activity via four receptors, EP1 to EP4, possible differences in EP signaling were investigated in WT and COX-2-/- mice. Following UVB exposure, protein levels of EP1, EP2, and EP4 were elevated in WT mice, but EP2 and EP4 levels were 50% lower in COX-2-/- mice. Activated cyclic AMP-dependent protein kinase (PKA) and Akt are downstream in EP2 and EP4 signaling, and their levels were reduced in UVB-exposed COX-2-/- mice. Furthermore, p-Bad (Ser(136) and Ser(155)), antiapoptotic products of activated Akt and PKA, respectively, were significantly reduced in UVB-exposed COX-2-/- mice. To further study the roles of EP2 and EP4, UVB-exposed CD-1 mice were topically treated with indomethacin to block endogenous PGE(2) production, and PGE(2), the EP2 agonist (butaprost) or EP4 agonist (PGE(1) alcohol), was applied. Indomethacin reduced PKA and Akt activation by approximately 60%, but PGE(2) and the agonists restored their activities. Furthermore, both agonists decreased apoptosis in COX-2-/- mice by 50%. The data suggest that COX-2-generated PGE(2) has antiapoptotic roles in UVB-exposed mouse skin that involves EP2- and EP4-mediated signaling. JF - Cancer research AU - Chun, Kyung-Soo AU - Akunda, Jacqueline K AU - Langenbach, Robert AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27709, USA. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 2015 EP - 2021 VL - 67 IS - 5 SN - 0008-5472, 0008-5472 KW - Bad protein, mouse KW - 0 KW - Ptger2 protein, mouse KW - Ptger4 protein, mouse KW - Receptors, Prostaglandin E KW - Receptors, Prostaglandin E, EP2 Subtype KW - Receptors, Prostaglandin E, EP4 Subtype KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - bcl-Associated Death Protein KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Dinoprostone KW - K7Q1JQR04M KW - Index Medicus KW - Animals KW - Dinoprostone -- physiology KW - Mice KW - Models, Biological KW - Tumor Suppressor Protein p53 -- metabolism KW - bcl-Associated Death Protein -- metabolism KW - Mice, Knockout KW - bcl-2-Associated X Protein -- metabolism KW - Mice, Inbred Strains KW - Mice, Inbred C57BL KW - Female KW - Receptors, Prostaglandin E -- metabolism KW - Cyclooxygenase 2 -- physiology KW - Ultraviolet Rays KW - Skin -- radiation effects KW - Skin -- enzymology KW - Cyclooxygenase 2 -- genetics KW - Skin -- metabolism KW - Apoptosis -- radiation effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70224314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cyclooxygenase-2+inhibits+UVB-induced+apoptosis+in+mouse+skin+by+activating+the+prostaglandin+E2+receptors%2C+EP2+and+EP4.&rft.au=Chun%2C+Kyung-Soo%3BAkunda%2C+Jacqueline+K%3BLangenbach%2C+Robert&rft.aulast=Chun&rft.aufirst=Kyung-Soo&rft.date=2007-03-01&rft.volume=67&rft.issue=5&rft.spage=2015&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dev Cell. 2002 Nov;3(5):607-8 [12431365] Toxicol Appl Pharmacol. 2004 Mar 15;195(3):298-308 [15020192] J Biol Chem. 2003 Apr 11;278(15):12752-8 [12556459] J Am Soc Nephrol. 2003 Jun;14(6):1427-34 [12761242] Mol Carcinog. 2003 Jul;37(3):149-57 [12884366] Cancer Res. 2003 Sep 1;63(17):5239-42 [14500353] Life Sci. 2003 Dec 5;74(2-3):143-53 [14607241] J Invest Dermatol. 2003 Oct;121(4):853-61 [14632205] Mol Carcinog. 2007 May;46(5):354-62 [17238138] J Clin Invest. 1990 Aug;86(2):566-74 [1696589] Cancer Cells. 1991 Jan;3(1):8-12 [2025494] Nature. 1993 Apr 29;362(6423):847-9 [8479522] Nature. 1993 Apr 29;362(6423):849-52 [8479523] Cell. 1995 Nov 3;83(3):493-501 [8521479] Crit Rev Biochem Mol Biol. 1996 Dec;31(5-6):381-404 [8994803] J Invest Dermatol. 1997 Dec;109(6):722-7 [9406811] Cancer Res. 1998 Jan 15;58(2):362-6 [9443418] Carcinogenesis. 1998 May;19(5):723-9 [9635856] Curr Opin Cell Biol. 1998 Dec;10(6):791-7 [9914179] J Biol Chem. 1999 Apr 16;274(16):10911-5 [10196169] Biochem Pharmacol. 1999 Oct 15;58(8):1237-46 [10487525] Oncogene. 2005 Feb 24;24(9):1634-40 [15608668] Mol Cancer Res. 2005 Feb;3(2):90-9 [15755875] Cancer Res. 2005 May 1;65(9):3853-60 [15867384] Int J Cancer. 2005 Oct 10;116(6):847-52 [15856465] J Biol Chem. 2005 Sep 16;280(37):32379-88 [16046401] J Invest Dermatol. 2005 Oct;125(4):818-25 [16185283] Oncol Rep. 2006 Feb;15(2):471-7 [16391871] J Invest Dermatol. 2006 Jan;126(1):205-11 [16417238] Cancer Res. 2006 Jul 15;66(14):7059-66 [16849551] J Invest Dermatol. 2007 Jan;127(1):214-21 [16917495] Cancer Res. 2002 Nov 1;62(21):6323-8 [12414664] J Environ Pathol Toxicol Oncol. 2002;21(2):183-91 [12086405] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4361-6 [11904361] J Biol Chem. 2002 Jan 11;277(2):1340-8 [11694504] Annu Rev Pharmacol Toxicol. 2001;41:661-90 [11264472] Biochem J. 2000 Jul 15;349(Pt 2):547-57 [10880354] Annu Rev Biochem. 2000;69:145-82 [10966456] Redox Rep. 2000;5(2-3):128-9 [10939292] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9215-20 [10908664] Annu Rev Biochem. 1999;68:821-61 [10872467] Genes Dev. 1999 Nov 15;13(22):2905-27 [10579998] Am J Physiol Gastrointest Liver Physiol. 2003 Mar;284(3):G490-8 [12431904] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of birth defects according to maternal therapy among infants in the Women and Infants Transmission Study. AN - 70221585; 17159659 AB - To evaluate rate and types of birth defects according to timing of antiretroviral exposure among babies born to HIV-infected women. Anomalies identified during the prenatal, neonatal, or follow-up period were classified using criteria of the Antiretroviral Pregnancy Registry. Antiretroviral use was classified as none, second or third trimester only, or first trimester. From January 1, 1990 through June 30, 2004, 2527 live births (LBs) occurred to 2353 women. Defects were identified in 90 babies for a rate of 3.56 defects per 100 LBs. The rate of defects was 3.19 per 100 LBs (24 of 752 LBs) with first-trimester antiretroviral exposure, 3.54 per 100 LBs (41 of 1158 LBs) with exposure later in pregnancy, and 4.05 of 100 LBs (25 of 617 LBs) with no antiretroviral use. Only genital abnormalities, specifically hypospadias, were significantly increased among babies born to women with first-trimester exposure to antiretrovirals (7 of 382 male LBs) compared with the 2 other groups (2 of 892 male LBs; P = 0.007). On logistic regression, use of zidovudine in the first trimester was associated with hypospadias (adjusted odds ratio = 10.68, 95% confidence interval: 2.11 to 54.13; P = 0.004). In general, data were reassuring, although the frequency of exposure to newer agents was limited. The increased risk of hypospadias after first-trimester exposure must be explored, because this association has not been detected previously. JF - Journal of acquired immune deficiency syndromes (1999) AU - Watts, D Heather AU - Li, Daner AU - Handelsman, Ed AU - Tilson, Hugh AU - Paul, Mary AU - Foca, Marc AU - Vajaranant, Mark AU - Diaz, Clemente AU - Tuomala, Ruth AU - Thompson, Bruce AD - Pediatric, Adolescent, and Maternal AIDS Branch, Center for Research on Mothers and Infants, National Institute of Child Health and Human Development/NIH, 6100 Executive Boulevard, Bethesda, MD 20892, USA. heather.watts@nih.hhs.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 299 EP - 305 VL - 44 IS - 3 SN - 1525-4135, 1525-4135 KW - Anti-HIV Agents KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Infant KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Abnormalities, Drug-Induced KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - Pregnancy Complications, Infectious -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70221585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Assessment+of+birth+defects+according+to+maternal+therapy+among+infants+in+the+Women+and+Infants+Transmission+Study.&rft.au=Watts%2C+D+Heather%3BLi%2C+Daner%3BHandelsman%2C+Ed%3BTilson%2C+Hugh%3BPaul%2C+Mary%3BFoca%2C+Marc%3BVajaranant%2C+Mark%3BDiaz%2C+Clemente%3BTuomala%2C+Ruth%3BThompson%2C+Bruce&rft.aulast=Watts&rft.aufirst=D&rft.date=2007-03-01&rft.volume=44&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pesticide exposure and self-reported gestational diabetes mellitus in the Agricultural Health Study. AN - 70214542; 17327316 AB - To examine the association between pesticide use during pregnancy and gestational diabetes mellitus (GDM) among wives of licensed pesticide applicators. Using data from the Agricultural Health Study (AHS), we estimated the association between self-reported pesticide-related activities during the first trimester of the most recent pregnancy and GDM among 11,273 women whose pregnancy occurred within 25 years of enrollment. A total of 506 (4.5%) women reported having had GDM. Women who reported agricultural pesticide exposure (mixing or applying pesticides to crops or repairing pesticide application equipment) during pregnancy were more likely to report GDM (odds ratio [OR] 2.2 [95% CI 1.5-3.3]). We saw no association between residential pesticide exposure (applying pesticides in the home and garden during pregnancy) and GDM (1.0 [0.8-1.3]). Among women who reported agricultural exposure during pregnancy, risk of GDM was associated with ever-use of four herbicides (2,4,5-T; 2,4,5-TP; atrazine; or butylate) and three insecticides (diazinon, phorate, or carbofuran). These findings suggest that activities involving exposure to agricultural pesticides during the first trimester of pregnancy may increase the risk of GDM. JF - Diabetes care AU - Saldana, Tina M AU - Basso, Olga AU - Hoppin, Jane A AU - Baird, Donna D AU - Knott, Charles AU - Blair, Aaron AU - Alavanja, Michael C R AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, P.O. Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA. saldana@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 529 EP - 534 VL - 30 IS - 3 KW - Pesticides KW - 0 KW - Index Medicus KW - Parity KW - Educational Status KW - Humans KW - Continental Population Groups KW - Body Mass Index KW - North Carolina -- epidemiology KW - Smoking -- epidemiology KW - Pregnancy KW - Maternal Age KW - Adult KW - Surveys and Questionnaires KW - Middle Aged KW - Adolescent KW - Female KW - Iowa -- epidemiology KW - Agriculture KW - Diabetes, Gestational -- etiology KW - Diabetes, Gestational -- epidemiology KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70214542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes+care&rft.atitle=Pesticide+exposure+and+self-reported+gestational+diabetes+mellitus+in+the+Agricultural+Health+Study.&rft.au=Saldana%2C+Tina+M%3BBasso%2C+Olga%3BHoppin%2C+Jane+A%3BBaird%2C+Donna+D%3BKnott%2C+Charles%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R%3BSandler%2C+Dale+P&rft.aulast=Saldana&rft.aufirst=Tina&rft.date=2007-03-01&rft.volume=30&rft.issue=3&rft.spage=529&rft.isbn=&rft.btitle=&rft.title=Diabetes+care&rft.issn=1935-5548&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-27 N1 - Date created - 2007-02-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicol Sci. 2000 Aug;56(2):431-6 [10911003] Comp Biochem Physiol C Toxicol Pharmacol. 2004 Apr;137(4):343-7 [15228952] Hum Reprod Update. 2001 May-Jun;7(3):331-9 [11392380] Epidemiology. 2002 Jan;13(1):94-9 [11805592] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Environ Health Perspect. 2002 Sep;110(9):853-8 [12204817] Environ Health Perspect. 2003 May;111(5):724-30 [12727601] J Nutr. 2003 May;133(5 Suppl 2):1674S-1683S [12730484] Diabet Med. 2004 Feb;21(2):103-13 [14984444] Arch Med Res. 2004 May-Jun;35(3):241-5 [15163467] J Cell Sci. 1998 Nov;111 ( Pt 22):3311-22 [9788873] J Occup Environ Med. 2004 Aug;46(8):856-65 [15300138] Am J Med. 1971 Apr;50(4):475-92 [4324629] S Afr Med J. 1978 Aug 5;54(6):230-4 [715598] Diabetes. 1979 Dec;28(12):1039-57 [510803] J Environ Sci Health B. 1992 Oct;27(5):495-510 [1401727] Epidemiology. 1993 Jan;4(1):55-62 [8420582] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Diabetes Care. 1996 Jan;19(1):12-6 [8720526] Epidemiology. 1997 May;8(3):252-8 [9115019] Diabetes Care. 1998 Aug;21 Suppl 2:B9-13 [9704221] Am J Ind Med. 1998 Dec;34(6):581-7 [9816416] Occup Environ Med. 1999 Apr;56(4):270-6 [10450245] J Clin Invest. 2005 Mar;115(3):485-91 [15765129] J Clin Epidemiol. 2006 Apr;59(4):429-35 [16549266] Epidemiology. 2000 Jan;11(1):44-8 [10615842] Metabolism. 1999 Nov;48(11):1461-9 [10582558] J Assoc Physicians India. 2000 Dec;48(12):1197-9 [11280228] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes. AN - 69017554; 17197183 AB - A series of 5-arylidene-2,4-thiazolidinediones and its geranyloxy or prenyloxy derivative were synthesized and studied for their radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Their comparable scavenging activities were expressed as IC50 value. Compounds 2c, 2d, 4d, and 6a showed appreciable radical scavenging activities. The vanillin based thiazolidinedione compound 2c displayed highest activity comparable to that of alpha-tocopherol. But in vivo, compound 6a showed better results in inducing phase II detoxifying/antioxidative enzyme. JF - Bioorganic & medicinal chemistry letters AU - Hossain, Sk Ugir AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700 026, West Bengal, India. Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 1149 EP - 1154 VL - 17 IS - 5 SN - 0960-894X, 0960-894X KW - Antioxidants KW - 0 KW - Benzaldehydes KW - Biphenyl Compounds KW - Free Radical Scavengers KW - Picrates KW - Thiazolidinediones KW - vanillin KW - CHI530446X KW - 1,1-diphenyl-2-picrylhydrazyl KW - DFD3H4VGDH KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Index Medicus KW - Inhibitory Concentration 50 KW - Structure-Activity Relationship KW - Protein Prenylation KW - Thiazolidinediones -- chemical synthesis KW - Thiazolidinediones -- chemistry KW - Free Radical Scavengers -- chemistry KW - Free Radical Scavengers -- chemical synthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69017554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.atitle=Synthesis+of+O-prenylated+and+O-geranylated+derivatives+of+5-benzylidene2%2C4-thiazolidinediones+and+evaluation+of+their+free+radical+scavenging+activity+as+well+as+effect+on+some+phase+II+antioxidant%2Fdetoxifying+enzymes.&rft.au=Hossain%2C+Sk+Ugir%3BBhattacharya%2C+Sudin&rft.aulast=Hossain&rft.aufirst=Sk&rft.date=2007-03-01&rft.volume=17&rft.issue=5&rft.spage=1149&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry+letters&rft.issn=0960894X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving. AN - 69014693; 16893525 AB - We and others reported time-dependent increases in cue-induced cocaine seeking after withdrawal, suggesting that craving incubates over time. Recently, we found that central amygdala extracellular signal-regulated kinases (ERK) and glutamate are involved in this incubation. Here, we further explored the role of central amygdala glutamate in the incubation of cocaine craving by determining the effect of systemic or central amygdala injections of the mGluR2/3 agonist LY379268 (which decreases glutamate release) on cue-induced cocaine seeking during early and late withdrawal. Rats were trained to self-administer cocaine for 10 days (6 hours/day); infusions were paired with a tone-light cue. Cocaine seeking and craving after systemic or central amygdala injections of LY379268 were then assessed in extinction tests in the presence of the cocaine-associated cues during early (day 3) or late (day 21) withdrawal. Systemic (1.5 or 3 mg/kg) or central amygdala (.5 or 1.0 microg/side) injections of LY379268 attenuated enhanced extinction responding on day 21 but had no effect on lower extinction responding on day 3. Results confirm our previous findings on the role of central amygdala glutamate in the incubation of cocaine craving and together with previous reports suggest that mGluR(2/3) agonists should be considered in the treatment of drug relapse. JF - Biological psychiatry AU - Lu, Lin AU - Uejima, Jamie L AU - Gray, Sarah M AU - Bossert, Jennifer M AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA. linlu@bjmu.edu.cn Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 591 EP - 598 VL - 61 IS - 5 SN - 0006-3223, 0006-3223 KW - Amino Acids KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - Dopamine Uptake Inhibitors KW - LY 379268 KW - Receptors, Metabotropic Glutamate KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - Cocaine -- administration & dosage KW - Behavior, Animal KW - Drug Administration Routes KW - Rats KW - Self Administration KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Extinction, Psychological -- drug effects KW - Male KW - Amino Acids -- administration & dosage KW - Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage KW - Receptors, Metabotropic Glutamate -- administration & dosage KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Amygdala -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69014693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Systemic+and+central+amygdala+injections+of+the+mGluR%282%2F3%29+agonist+LY379268+attenuate+the+expression+of+incubation+of+cocaine+craving.&rft.au=Lu%2C+Lin%3BUejima%2C+Jamie+L%3BGray%2C+Sarah+M%3BBossert%2C+Jennifer+M%3BShaham%2C+Yavin&rft.aulast=Lu&rft.aufirst=Lin&rft.date=2007-03-01&rft.volume=61&rft.issue=5&rft.spage=591&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gelsolin: a novel thyroid hormone receptor-beta interacting protein that modulates tumor progression in a mouse model of follicular thyroid cancer. AN - 69013367; 17170101 AB - Follicular thyroid cancer (FTC) is known to metastasize to distant sites via hematogenous spread; however, the underlying pathways that contribute to metastasis remain unknown. Recent creation of a knockin mutant mouse that expresses a mutant thyroid hormone receptor-beta (TRbeta(PV/PV) mouse) that spontaneously develops thyroid cancer with metastasis similar to humans has provided new opportunities to study contributors to FTC metastasis. This study evaluates the role of gelsolin, an actin-regulatory protein, in modulating the metastatic potential of FTC. Gelsolin was previously found by cDNA microarray analysis to be down-regulated in TRbeta(PV/PV) mice as compared with wild-type mice. This study found an age-dependent reduction of gelsolin protein abundance in TRbeta(PV/PV) mice as tumorigenesis progressed. Knockdown of gelsolin by small interfering RNA resulted in increased tumor cell motility and increased gelsolin expression by histone deacetylase inhibitor (trichostatin A) led to decreased cell motility. Additional biochemical analyses demonstrated that gelsolin physically interacted with TRbeta1 or PV in vivo and in vitro. The interaction regions were mapped to the C terminus of gelsolin and the DNA binding domain of TR. The physical interaction of gelsolin with PV reduced its binding to actin, leading to disarrayed cytoskeletal architectures. These results suggest that PV-induced alteration of the actin/gelsolin cytoskeleton contributes to increased cell motility. Thus, the present study uncovered a novel PV-mediated oncogenic pathway that could contribute to the local tumor progression and metastatic potential of thyroid carcinogenesis. JF - Endocrinology AU - Kim, Caroline S AU - Furuya, Fumihiko AU - Ying, Hao AU - Kato, Yasuhito AU - Hanover, John A AU - Cheng, Sheue-yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892-4264, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 1306 EP - 1312 VL - 148 IS - 3 SN - 0013-7227, 0013-7227 KW - Actins KW - 0 KW - Gelsolin KW - Mutant Proteins KW - Thyroid Hormone Receptors beta KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cells, Cultured KW - Mutant Proteins -- metabolism KW - Cercopithecus aethiops KW - Disease Progression KW - Disease Models, Animal KW - Actins -- metabolism KW - Mice KW - Cell Movement -- genetics KW - Mice, Transgenic KW - Protein Binding KW - Thyroid Gland -- metabolism KW - Thyroid Hormone Receptors beta -- metabolism KW - Gelsolin -- metabolism KW - Gelsolin -- physiology KW - Thyroid Neoplasms -- pathology KW - Thyroid Hormone Receptors beta -- genetics KW - Carcinoma, Papillary, Follicular -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69013367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Blood+Pressure+Increases+with+Norepinephrine+Infusion+Improved+Survival+with+Lipopolysaccharide+%28LPS%29+but+not+Anthrax+Lethal+Toxin+%28LeTx%29+Challenge+in+Rats&rft.au=Li%2C+Y.%3BCui%2C+X%3BSu%2C+J.%3BSherer%2C+K%3BLeppla%2C+S%3BMoayeri%2C+M%3BKenyon%2C+N%3BScher%2C+D%3BFitz%2C+Y%3BEichacker%2C+P+Q&rft.aulast=Li&rft.aufirst=Y.&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice. AN - 69011663; 17158205 AB - Levels of 2-methoxyestradiol (2ME(2)), an endogenous metabolite of estradiol, are highly elevated during late stages of pregnancy when mammary glands have differentiated with the formation of alveolar structures producing milk proteins. Based upon our previous demonstration that 2ME(2) induces mammary ductal dilation associated with expression of mammary differentiation markers when administered to transgenic mice that spontaneously develop mammary cancer, we studied the effects of 2ME(2) on normal mammary gland development. The results of this study demonstrate that 2ME(2) can induce a partial differentiation of normal mammary glands in virgin mice, as evidenced by the appearance of limited numbers of alveolar cells and significantly increased expression of the differentiation markers beta-casein and whey acidic protein. 2ME(2)-induced differentiation is associated with inhibition of expression of inhibitor of differentiation 1 (Id-1) in normal mammary epithelial cells through elements in the 5'-flanking region of the Id-1 gene. Microarray analysis revealed that 2ME(2)-induced differentiation of the mammary gland shares some significant similarities in gene expression with that of mammary glands from late-stage pregnancy, including elevated expression of many milk protein differentiation markers. However, several genes are differentially regulated between 2ME(2)-treated mammary glands and differentiated mammary glands through pregnancy. Significantly, amphiregulin, ATF3, serpine2, and SOX6 were up-regulated in 2ME(2)-treated mammary glands but not in mammary glands from pregnant mice. Using the SCp2 differentiation cell line system, we demonstrate that 2ME(2) induces differentiation through the down-regulation of Id-1 and up-regulation of amphiregulin. Administration of amphiregulin to SCp2 cells induced differentiation, whereas inhibition of 2ME(2)-induced expression of amphiregulin by small interfering RNA blocked differentiation. Estrogen receptor-negative SCp2 cells differentiate in response to 2ME(2), but not estradiol, suggesting that 2ME(2) operates through an estrogen receptor-independent mechanism. These data demonstrate that 2ME(2) can induce a partial differentiation of the mammary gland through mechanisms that differ from those normally used during pregnancy. JF - Endocrinology AU - Huh, Jung-Im AU - Qiu, Ting Hu AU - Chandramouli, Gadisetti V R AU - Charles, Rhonda AU - Wiench, Malgorzata AU - Hager, Gordon L AU - Catena, Raul AU - Calvo, Alfonso AU - LaVallee, Theresa M AU - Desprez, Pierre-Yves AU - Green, Jeffrey E AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Building 41, 41 Medlars Drive, Bethesda, MD 20892, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 1266 EP - 1277 VL - 148 IS - 3 SN - 0013-7227, 0013-7227 KW - Amphiregulin KW - 0 KW - Areg protein, mouse KW - EGF Family of Proteins KW - Glycoproteins KW - Idb1 protein, mouse KW - Inhibitor of Differentiation Protein 1 KW - Intercellular Signaling Peptides and Proteins KW - Milk Proteins KW - Estradiol KW - 4TI98Z838E KW - 2-methoxyestradiol KW - 6I2QW73SR5 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Abridged Index Medicus KW - Index Medicus KW - Mice, Inbred Strains KW - Gene Expression Profiling KW - Animals KW - Cells, Cultured KW - Milk Proteins -- metabolism KW - Inhibitor of Differentiation Protein 1 -- metabolism KW - Mice KW - Signal Transduction KW - Female KW - Pregnancy KW - Estradiol -- analogs & derivatives KW - Mammary Glands, Animal -- drug effects KW - Mammary Glands, Animal -- cytology KW - Estradiol -- pharmacology KW - Receptor, Epidermal Growth Factor -- physiology KW - Cell Differentiation -- drug effects KW - Intercellular Signaling Peptides and Proteins -- physiology KW - Glycoproteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=2-methoxyestradiol+induces+mammary+gland+differentiation+through+amphiregulin-epithelial+growth+factor+receptor-mediated+signaling%3A+molecular+distinctions+from+the+mammary+gland+of+pregnant+mice.&rft.au=Huh%2C+Jung-Im%3BQiu%2C+Ting+Hu%3BChandramouli%2C+Gadisetti+V+R%3BCharles%2C+Rhonda%3BWiench%2C+Malgorzata%3BHager%2C+Gordon+L%3BCatena%2C+Raul%3BCalvo%2C+Alfonso%3BLaVallee%2C+Theresa+M%3BDesprez%2C+Pierre-Yves%3BGreen%2C+Jeffrey+E&rft.aulast=Huh&rft.aufirst=Jung-Im&rft.date=2007-03-01&rft.volume=148&rft.issue=3&rft.spage=1266&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-04 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bayesian methods for highly correlated exposure data. AN - 69008796; 17272963 AB - Studies that include individuals with multiple highly correlated exposures are common in epidemiology. Because standard maximum likelihood techniques often fail to converge in such instances, hierarchical regression methods have seen increasing use. Bayesian hierarchical regression places prior distributions on exposure-specific regression coefficients to stabilize estimation and incorporate prior knowledge, if available. A common parametric approach in epidemiology is to treat the prior mean and variance as fixed constants. An alternative parametric approach is to place distributions on the prior mean and variance to allow the data to help inform their values. As a more flexible semiparametric option, one can place an unknown distribution on the coefficients that simultaneously clusters exposures into groups using a Dirichlet process prior. We also present a semiparametric model with a variable-selection prior to allow clustering of coefficients at 0. We compare these 4 hierarchical regression methods and demonstrate their application in an example estimating the association of herbicides with retinal degeneration among wives of pesticide applicators. JF - Epidemiology (Cambridge, Mass.) AU - MacLehose, Richard F AU - Dunson, David B AU - Herring, Amy H AU - Hoppin, Jane A AD - Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. maclehoser@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 199 EP - 207 VL - 18 IS - 2 SN - 1044-3983, 1044-3983 KW - Herbicides KW - 0 KW - Index Medicus KW - Herbicides -- adverse effects KW - Retinal Degeneration -- epidemiology KW - Humans KW - Nonlinear Dynamics KW - Bias (Epidemiology) KW - Retinal Degeneration -- etiology KW - Statistics, Nonparametric KW - Confounding Factors (Epidemiology) KW - Environmental Exposure KW - Bayes Theorem KW - Models, Statistical UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69008796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Bayesian+methods+for+highly+correlated+exposure+data.&rft.au=MacLehose%2C+Richard+F%3BDunson%2C+David+B%3BHerring%2C+Amy+H%3BHoppin%2C+Jane+A&rft.aulast=MacLehose&rft.aufirst=Richard&rft.date=2007-03-01&rft.volume=18&rft.issue=2&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-22 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 2007 Mar;18(2):186-90 [17301703] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alcohol use and tobacco abstinence among adolescents in cessation treatment: preliminary findings. AN - 68412345; 16814935 AB - Although adult alcohol use is negatively associated with tobacco cessation, this relationship has not been reported for adolescents. We assessed the relationship between alcohol use and point prevalence abstinence from smoking in a sample of tobacco-dependent adolescents undergoing cessation treatment. Alcohol use both at baseline and) during tobacco cessation treatment was examined as predicting smoking abstinence in 101 adolescents (age=15.1years, S.D.=1.31years; age at first cigarette=11.3years, S.D.=1.93years; age at first drink=12.01years, S.D.=2.87years) attending a total of 642 treatment visits. Mixed regression analysis showed that participants who reported alcohol use during tobacco cessation treatment were significantly less likely to abstain from tobacco smoking (OR=0.42, 95% CI=0.23-0.78, t=-2.78, df=540, p=0.0057). However, pre-enrollment alcohol use was not significantly associated with either short- or long-term tobacco abstinence. If confirmed in a larger group of adolescents, our findings suggest that youths attempting to quit smoking should abstain from alcohol. JF - Addictive behaviors AU - Jaszyna-Gasior, Maria AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, USA. Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 617 EP - 621 VL - 32 IS - 3 SN - 0306-4603, 0306-4603 KW - Chewing Gum KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Regression Analysis KW - Nicotine -- therapeutic use KW - Administration, Cutaneous KW - Tobacco Use Disorder -- drug therapy KW - Humans KW - Tobacco Use Disorder -- psychology KW - Adolescent KW - Male KW - Female KW - Smoking Cessation -- psychology KW - Alcohol Drinking -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68412345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Alcohol+use+and+tobacco+abstinence+among+adolescents+in+cessation+treatment%3A+preliminary+findings.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-29 N1 - Date created - 2007-01-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Personality Traits in Sardinia: Testing Founder Population Effects on Trait Means and Variances AN - 57228502; 200716737 AB - Potential founder population effects on personality trait means and variances were examined in a large, genetically homogeneous sample (N = 5,669) from the Ogliastra, an isolated region within Sardinia, Italy. The Italian version of the Revised NEO Personality Inventory showed good psychometric properties: Internal consistency reliabilities ranged from 0.80 to 0.87; the factor structure replicated the American normative structure; and associations with education and gender replicated cross-cultural patterns. The hypothesis that means trait levels in the Sardinian founder population would differ from mainland Italian values was not supported. Phenotypic variation in this founder population was within the range found in other cultures. However, the hypothesis of restricted phenotypic variation was supported for all five factors and 28 of the 30 facets when a Sardinian subsample matched on age, sex, and education was compared to a mainland Italian sample. The genetic homogeneity effect on the phenotypic expression of complex traits merits further exploration. Adapted from the source document. JF - Behavior Genetics AU - Costa, Paul T, Jr AU - Terracciano, Antonio AU - Uda, Manuela AU - Vacca, Loredana AU - Mameli, Cinzia AU - Pilia, Giuseppe AU - Zonderman, Alan B AU - Lakatta, Edward AU - Schlessinger, David AU - McCrae, Robert R AD - National Instit Aging, NIH, DHHS, Baltimore, MD costap@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 376 EP - 387 PB - Springer Science+Business Media, Inc, New York, NY VL - 37 IS - 2 SN - 0001-8244, 0001-8244 KW - Five-Factor Model of personality, Genetic homogeneity, Founder population, Cross-cultural, Complex trait, QTL KW - Five factor model KW - Personality KW - Psychometric properties KW - Genetic family histories KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57228502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Personality+Traits+in+Sardinia%3A+Testing+Founder+Population+Effects+on+Trait+Means+and+Variances&rft.au=Costa%2C+Paul+T%2C+Jr%3BTerracciano%2C+Antonio%3BUda%2C+Manuela%3BVacca%2C+Loredana%3BMameli%2C+Cinzia%3BPilia%2C+Giuseppe%3BZonderman%2C+Alan+B%3BLakatta%2C+Edward%3BSchlessinger%2C+David%3BMcCrae%2C+Robert+R&rft.aulast=Costa&rft.aufirst=Paul&rft.date=2007-03-01&rft.volume=37&rft.issue=2&rft.spage=376&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-006-9103-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-09-28 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Five factor model; Personality; Genetic family histories; Psychometric properties DO - http://dx.doi.org/10.1007/s10519-006-9103-6 ER - TY - JOUR T1 - Aggression, psychopathy and free will from a cognitive neuroscience perspective AN - 57102910; 200801550 AB - This article considers the notion of free will in the context of aggression and psychopathy research. The philosophical literature is very briefly considered to determine under what assumptions free will can be considered to exist. However, as the issue of free will is very difficult to address directly, the prime focus of this article is on issues raised in the philosophical debate, that may be empirically tractable and that are relevant to the understanding of psychopathy. Specifically, the following issues are considered: (1) The distinction between automatic and controlled processing; (2) Impairment related to automatic processing in individuals with psychopathy; and (3) Impairment related to controlled behavior in individuals with psychopathy. It is concluded that, while there is not a direct mapping of the automatic versus controlled processing dichotomy on to the reactive versus instrumental aggression dichotomy, some overlap can be considered. As such, it is possible to consider that certain episodes of reactive aggression might be considered to occur in the absence of free will. However, instrumental aggression, at least from a compatibilist perspective, must involve free will. Published in 2007 by John Wiley & Sons, Ltd. [Copyright 2007 John Wiley and Sons, Ltd.] JF - Behavioral Sciences & the Law AU - Blair, R J R Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 321 EP - 331 PB - John Wiley & Sons, Chichester UK VL - 25 IS - 2 SN - 0735-3936, 0735-3936 KW - Automatic processes KW - Psychopathy KW - Neurosciences KW - Aggression KW - Cognition KW - Free will KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57102910?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavioral+Sciences+%26+the+Law&rft.atitle=Aggression%2C+psychopathy+and+free+will+from+a+cognitive+neuroscience+perspective&rft.au=Blair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=R+J&rft.date=2007-03-01&rft.volume=25&rft.issue=2&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Behavioral+Sciences+%26+the+Law&rft.issn=07353936&rft_id=info:doi/10.1002%2Fbsl.750 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - CODEN - BSLADR N1 - SubjectsTermNotLitGenreText - Free will; Psychopathy; Aggression; Neurosciences; Cognition; Automatic processes DO - http://dx.doi.org/10.1002/bsl.750 ER - TY - JOUR T1 - Integrating earth science and epidemiology; modeling the probability of arsenic in New England groundwater for exposure assessment AN - 50863340; 2008-095445 AB - For over five decades, the states of Maine, New Hampshire, and Vermont reported excess mortality rates from bladder cancer in males and females. One hypothesized explanation for this excess is the presence of elevated concentrations in drinking water of inorganic arsenic, a substance known as a bladder carcinogen at high levels. In northern New England, about 40% of residents use private wells, and in some areas more than 30% of private wells have inorganic arsenic concentrations that exceed the drinking water standard of 10 mu g/L. Recent ecological evidence suggests that bladder cancer mortality in the region is correlated with private well use. An epidemiologic study of bladder cancer in northern New England is underway. The purpose is to explain the excess of bladder cancer, with a major focus on the risk of long-term consumption of arsenic in drinking water. The study includes an estimate of arsenic exposure and exposure uncertainty during adult life for each study subject based on residential history, arsenic concentrations in drinking water wells at current and past residences, and water-quality and use data from public water supplies. In some cases, there are gaps in the exposure profile because of unavailable data. To estimate arsenic concentrations in the gaps, a process-based statistical model has been developed to identify geographic areas in New England with a probability of arsenic concentrations exceeding 5 mu g/L in drinking water wells. In the model, multivariate logistic regression is used to estimate the probability of occurrence of elevated arsenic concentrations in ground water. The model is based on geologic, hydrologic, and landscape information, including specific geologic formation units, arsenic concentrations in stream sediments, areas of Pleistocene marine inundation, and proximity to intrusive granitic plutons. These and other hydrologic and landscape variables related to arsenic sources and ground-water geochemical factors and residence time are shown to increase the probability of elevated arsenic concentrations in ground water. Previous studies suggest that arsenic in bedrock ground water may be partly from past arsenical pesticide use but variables representing historic agricultural inputs do not improve the model, indicating that this source does not significantly contribute to current arsenic concentrations. JF - Abstracts with Programs - Geological Society of America AU - Ayotte, Joseph D AU - Nuckols, John R AU - Cantor, Kenneth P AU - Robinson, Gilpin R AU - Baris, Dalsu AU - Hayes, Laura AU - Karagas, Margaret AU - Bress, Bill AU - Silverman, Debra AU - Lubin, Jay AU - Anonymous Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 56 EP - 57 PB - Geological Society of America (GSA), Boulder, CO VL - 39 IS - 1 SN - 0016-7592, 0016-7592 KW - United States KW - medical geology KW - drinking water KW - ground water KW - New Hampshire KW - Cenozoic KW - carcinogens KW - New England KW - ecology KW - bedrock KW - concentration KW - water supply KW - toxic materials KW - Quaternary KW - arsenic KW - pollution KW - Vermont KW - aquifers KW - models KW - metals KW - Pleistocene KW - risk assessment KW - pesticides KW - Maine KW - water wells KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50863340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abstracts+with+Programs+-+Geological+Society+of+America&rft.atitle=Integrating+earth+science+and+epidemiology%3B+modeling+the+probability+of+arsenic+in+New+England+groundwater+for+exposure+assessment&rft.au=Ayotte%2C+Joseph+D%3BNuckols%2C+John+R%3BCantor%2C+Kenneth+P%3BRobinson%2C+Gilpin+R%3BBaris%2C+Dalsu%3BHayes%2C+Laura%3BKaragas%2C+Margaret%3BBress%2C+Bill%3BSilverman%2C+Debra%3BLubin%2C+Jay%3BAnonymous&rft.aulast=Ayotte&rft.aufirst=Joseph&rft.date=2007-03-01&rft.volume=39&rft.issue=1&rft.spage=56&rft.isbn=&rft.btitle=&rft.title=Abstracts+with+Programs+-+Geological+Society+of+America&rft.issn=00167592&rft_id=info:doi/ LA - English DB - GeoRef N1 - Conference title - Geological Society of America, Northeastern Section, 42nd annual meeting N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. Reference includes data supplied by the Geological Society of America, Boulder, CO, United States N1 - Date revised - 2008-01-01 N1 - PubXState - CO N1 - Last updated - 2012-06-07 N1 - CODEN - GAAPBC N1 - SubjectsTermNotLitGenreText - aquifers; arsenic; bedrock; carcinogens; Cenozoic; concentration; drinking water; ecology; ground water; Maine; medical geology; metals; models; New England; New Hampshire; pesticides; Pleistocene; pollution; Quaternary; risk assessment; toxic materials; United States; Vermont; water supply; water wells ER - TY - JOUR T1 - Mercury-selenium association in Antarctic seal hairs and animal excrements over the past 1,500 years AN - 50622233; 2008-111694 AB - Strong positive correlations between selenium (Se) and total mercury (HgT) contents in the liver of marine mammals and mercury mine workers in modern times have been documented in numerous investigations. Herein, we report a positive correlation between Se and HgT concentrations over the past 1,500 years in the seal hairs and in the lake sediments amended by seal or penguin excrements on King George Island (63 degrees 23'S, 57 degrees 00'W), West Antarctica. Because the changes in the input of Se and Hg into the marine environments of the studied sites do not seem to be synchronous, this striking correlation indicates a self-protection mechanism in Antarctic seals and penguins: Every time there is heavier Hg burden, more Se is accumulated to reduce the toxicity of Hg. This positive correlation between Hg and Se contents in the seal hairs and excrement sediments, however, becomes insignificant in the recent 50 years for unknown reasons. JF - Environmental Toxicology and Chemistry AU - Yin, Xuebin AU - Sun, Liguang AU - Zhu, Renbin AU - Liu, Xiaodong AU - Ruan, Diyun AU - Wang, Yuhong Y1 - 2007/03// PY - 2007 DA - March 2007 SP - 381 EP - 386 PB - SETAC, Pensacola, FL VL - 26 IS - 3 SN - 0730-7268, 0730-7268 KW - sea water KW - selenium KW - Pinnipedia KW - Holocene KW - Ardley Island KW - Fildes Peninsula KW - bioaccumulation KW - Cenozoic KW - Theria KW - King George Island KW - toxicity KW - South Shetland Islands KW - noble gases KW - helium KW - ecology KW - Eutheria KW - Chordata KW - Quaternary KW - Carnivora KW - Mammalia KW - correlation KW - indicators KW - biota KW - adaptation KW - habitat KW - Antarctica KW - marine environment KW - lacustrine environment KW - Vertebrata KW - upper Holocene KW - Scotia Sea Islands KW - Tetrapoda KW - 22:Environmental geology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/50622233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Chemistry&rft.atitle=Mercury-selenium+association+in+Antarctic+seal+hairs+and+animal+excrements+over+the+past+1%2C500+years&rft.au=Yin%2C+Xuebin%3BSun%2C+Liguang%3BZhu%2C+Renbin%3BLiu%2C+Xiaodong%3BRuan%2C+Diyun%3BWang%2C+Yuhong&rft.aulast=Yin&rft.aufirst=Xuebin&rft.date=2007-03-01&rft.volume=26&rft.issue=3&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Chemistry&rft.issn=07307268&rft_id=info:doi/10.1897%2F06-128 L2 - http://www3.interscience.wiley.com/journal/122563640/home?CRETRY=1&SRETRY=0 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2008-01-01 N1 - Number of references - 40 N1 - PubXState - FL N1 - Document feature - illus. incl. 1 table N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - adaptation; Antarctica; Ardley Island; bioaccumulation; biota; Carnivora; Cenozoic; Chordata; correlation; ecology; Eutheria; Fildes Peninsula; habitat; helium; Holocene; indicators; King George Island; lacustrine environment; Mammalia; marine environment; noble gases; Pinnipedia; Quaternary; Scotia Sea Islands; sea water; selenium; South Shetland Islands; Tetrapoda; Theria; toxicity; upper Holocene; Vertebrata DO - http://dx.doi.org/10.1897/06-128 ER - TY - CPAPER T1 - Health Behaviors and Health-Related Quality of Life of Adult Non-Hodgkin Lymphoma Survivors: Results from the ECHOS-NHL Study T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589321; 4551902 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Bellizzi, Keith Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Lymphoma KW - Quality of life KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.atitle=Health+Behaviors+and+Health-Related+Quality+of+Life+of+Adult+Non-Hodgkin+Lymphoma+Survivors%3A+Results+from+the+ECHOS-NHL+Study&rft.au=Bellizzi%2C+Keith&rft.aulast=Bellizzi&rft.aufirst=Keith&rft.date=2007-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Perception, Self-Efficacy and Cancer Survivorship: Testing the Risk Perception Attitude Framework in Adult Cancer Survivors T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589110; 4551933 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Beckjord, Ellen Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Cancer KW - Perception KW - Attitudes KW - Survival KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Genome-wide+Association+with+Adiposity-related+Traits%3A+The+Framingham+Heart+Study+100K+Project&rft.au=Fox%2C+Caroline+S%3BHeard-Costa%2C+Nancy%3BCupples%2C+L+Adrienne%3BDupuis%2C+Josee%3BVasan%2C+Ramachandran+S%3BAtwood%2C+Larry+D&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are Cancer Survivors Receiving Adequate Communication about Medical Tests and Symptoms Management from Their Follow-Up Care Physicians? T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40589034; 4551918 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Arora, Neeraj Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Cancer KW - Communication KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40589034?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.atitle=Are+Cancer+Survivors+Receiving+Adequate+Communication+about+Medical+Tests+and+Symptoms+Management+from+Their+Follow-Up+Care+Physicians%3F&rft.au=Arora%2C+Neeraj&rft.aulast=Arora&rft.aufirst=Neeraj&rft.date=2007-03-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=4th+Annual+Conference+of+the+American+Psychosocial+Oncology+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of Baseline Psychosocial Well-Being on Hospitalization and Survival following Allogeneic Hematopoietic Stem Cell Transplantation T2 - 4th Annual Conference of the American Psychosocial Oncology Society AN - 40588995; 4551903 JF - 4th Annual Conference of the American Psychosocial Oncology Society AU - Bevans, Margaret Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 KW - Stem cells KW - Survival KW - Cell survival KW - Transplantation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40588995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+and+their+Association+with+Coronary+and+Aortic+Artery+Calcification%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BMassaro%2C+Joseph+M%3BPou%2C+Karla+M%3BLarson%2C+Martin+G%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.apos-society.org/professionals/meetings-ed/conference/2007/ 2007-schedule-details.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Are there long-term effects of early child care? AN - 36638347; 3410540 AB - Effects of early child care on children's functioning from 41/2 years through the end of 6th grade (M age = 12.0 years) were examined in the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development (n = 1,364). The results indicated that although parenting was a stronger and more consistent predictor of children's development than early child-care experience, higher quality care predicted higher vocabulary scores and more exposure to center care predicted more teacher-reported externalizing problems. Discussion focuses on mechanisms responsible for these effects, the potential collective consquences of small child-care effects, and the importance of the ongoing follow-up at age 15. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Belsky, Jay AU - Vandell, Deborah Lowe AU - Burchinal, Margaret AU - Clarke-Stewart, K Alison AU - McCartney, Kathleen AU - Owen, Margaret Tresch AD - Birkbeck College ; University of California, Irvine ; University of North Carolina, Chapel Hill ; Harvard University ; University of Texas, Dallas Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 681 EP - 701 VL - 78 IS - 2 SN - 0009-3920, 0009-3920 KW - Sociology KW - Learning KW - Parenting KW - Parent-child relations KW - Vocabulary KW - Language acquisition KW - Child development KW - Child care KW - Child health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36638347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Are+there+long-term+effects+of+early+child+care%3F&rft.au=Belsky%2C+Jay%3BVandell%2C+Deborah+Lowe%3BBurchinal%2C+Margaret%3BClarke-Stewart%2C+K+Alison%3BMcCartney%2C+Kathleen%3BOwen%2C+Margaret+Tresch&rft.aulast=Belsky&rft.aufirst=Jay&rft.date=2007-03-01&rft.volume=78&rft.issue=2&rft.spage=681&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2192; 2197 2212 6075 3483; 2199 5772; 9183; 13341 7226; 7227 7239 7226; 9178 4777 6093 6823; 7278 12929 7073 ER - TY - JOUR T1 - Teachers' education, classroom quality, and young children's academic skills: results from seven studies of preschool programs AN - 36638069; 3410533 AB - In an effort to provide high-quality preschool education, policymakers are increasingly requiring public preschool teachers to have at least a Bachelor's degree, preferably in early childhood education. Seven major studies of early care and education were used to predict classroom quality and children's academic outcomes from the educational attainment and major of teachers of 4-year-olds. The findings indicate largely null or contradictory associations, indicating that policies focused solely on increasing teachers' education will not suffice for improving classroom quality or maximizing children's academic gains. Instead, education will not suffice of improving classroom quality or maximizing children's academic gains. Instead, raising the effectiveness of early childhood education will require a broad range of professional development activities and supports targeted toward teacher's toward teachers' interactions with children. Reprinted by permission of the University of Chicago Press. © All rights reserved JF - Child development AU - Early, Diane M AU - Maxwell, Kelly L AU - Burchinal, Margaret AU - Alva, Soumya AU - Bender, Randall H AU - Bryant, Donna AU - Cai, Karen AU - Clifford, Richard M AU - Ebanks, Caroline AU - Griffin, James A AU - Henry, Gary T AU - Howes, Carollee AU - Iriondo-Perez, Jeniffer AU - Jeon, Hyun-Joo AU - Mashburn, Andrew J AU - Peisner-Feinberg, Ellen AU - Pianta, Robert C AU - Vandergrift, Nathan AU - Zill, Nicholas AD - University of North Carolina, Chapel Hill ; Westat Inc. ; RTI International ; US Department of Education ; National Institutes of Health ; University of California, Los Angeles ; University of Virginia Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 558 EP - 580 VL - 78 IS - 2 SN - 0009-3920, 0009-3920 KW - Sociology KW - Qualitative analysis KW - Academic achievement KW - Pre-school education KW - Teacher training KW - Social interaction KW - Classrooms KW - Child development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36638069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+development&rft.atitle=Teachers%27+education%2C+classroom+quality%2C+and+young+children%27s+academic+skills%3A+results+from+seven+studies+of+preschool+programs&rft.au=Early%2C+Diane+M%3BMaxwell%2C+Kelly+L%3BBurchinal%2C+Margaret%3BAlva%2C+Soumya%3BBender%2C+Randall+H%3BBryant%2C+Donna%3BCai%2C+Karen%3BClifford%2C+Richard+M%3BEbanks%2C+Caroline%3BGriffin%2C+James+A%3BHenry%2C+Gary+T%3BHowes%2C+Carollee%3BIriondo-Perez%2C+Jeniffer%3BJeon%2C+Hyun-Joo%3BMashburn%2C+Andrew+J%3BPeisner-Feinberg%2C+Ellen%3BPianta%2C+Robert+C%3BVandergrift%2C+Nathan%3BZill%2C+Nicholas&rft.aulast=Early&rft.aufirst=Diane&rft.date=2007-03-01&rft.volume=78&rft.issue=2&rft.spage=558&rft.isbn=&rft.btitle=&rft.title=Child+development&rft.issn=00093920&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 2197 2212 6075 3483; 12586 12894; 10002 4049; 501 542 8322; 2362 11324; 11860 11907; 10519 3279 971 3286 ER - TY - JOUR T1 - Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease AN - 217846455; 17213842 AB - Although the general association of the inflammatory bowel disease (IBD) 5 region on chromosome 5q31 to Crohn's disease (CD) has been replicated repeatedly, the identity of the precise causal variant within the region remains unknown. A recent report proposed polymorphisms in solute carrier family 22, member 4 (SLC22A4) organic cation transporter 1(OCTN1) and solute carrier family 22, member 5 (SLC22A5) (OCTN2) as responsible for the IBD5 association, but definitive, large-sample comparison of those polymorphisms with others known to be in strong linkage disequilibrium was not performed. We evaluated 1879 affected offspring and parents ascertained by a North American IBD Genetics Consortium for six IBD5 tag single nucleotide polymorphisms (SNPs) to evaluate association localization and ethnic and subphenotypic specificity. We confirm association to the IBD5 region (best SNP IGR2096a_1/rs12521868, P<0.0005) and show this association to be exclusive to the non-Jewish (NJ) population (P=0.00005) (risk allele undertransmitted in Ashkenazi Jews). Using Phase II HapMap data, we demonstrate that there are a set of polymorphisms, spanning genes from prolyl 4-hydroxylase (P4HA2) through interferon regulatory factor 1 (IRF1) with equivalent statistical evidence of association to the reported SLC22A4 variant and that each, by itself, could entirely explain the IBD5 association to CD. Additionally, the previously reported SLC22A5 SNP is rejected as the potential causal variant. No specificity of association was seen with respect to disease type and location, and a modest association to ulcerative colitis is also observed. We confirm the importance of IBD5 to CD susceptibility, demonstrate that the locus may play a role in NJ individuals only, and establish that IRF1, PDLIM, and P4HA2 may be equally as likely to contain the IBD5 causal variant as the OCTN genes. JF - European Journal of Human Genetics : EJHG AU - Silverberg, Mark S AU - Duerr, Richard H AU - Brant, Steven R AU - Bromfield, Gillian AU - Datta, Lisa W AU - Jani, Niraj AU - Kane, Sunanda V AU - Rotter, Jerome I AU - Schumm, L Philip AU - A Hillary Steinhart AU - Taylor, Kent D AU - Yang, Huiying AU - Cho, Judy H AU - Rioux, John D AU - Daly, Mark J Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 328 EP - 35 CY - Leiden PB - Nature Publishing Group VL - 15 IS - 3 SN - 10184813 KW - Medical Sciences KW - Polymorphism, Single Nucleotide KW - Haplotypes KW - Humans KW - Adult KW - Jews -- genetics KW - Male KW - Female KW - Genetic Predisposition to Disease -- ethnology KW - Crohn Disease -- ethnology KW - Chromosomes, Human, Pair 5 -- genetics KW - Crohn Disease -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/217846455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Human+Genetics+%3A+EJHG&rft.atitle=Refined+genomic+localization+and+ethnic+differences+observed+for+the+IBD5+association+with+Crohn%27s+disease&rft.au=Silverberg%2C+Mark+S%3BDuerr%2C+Richard+H%3BBrant%2C+Steven+R%3BBromfield%2C+Gillian%3BDatta%2C+Lisa+W%3BJani%2C+Niraj%3BKane%2C+Sunanda+V%3BRotter%2C+Jerome+I%3BSchumm%2C+L+Philip%3BA+Hillary+Steinhart%3BTaylor%2C+Kent+D%3BYang%2C+Huiying%3BCho%2C+Judy+H%3BRioux%2C+John+D%3BDaly%2C+Mark+J&rft.aulast=Silverberg&rft.aufirst=Mark&rft.date=2007-03-01&rft.volume=15&rft.issue=3&rft.spage=328&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Human+Genetics+%3A+EJHG&rft.issn=10184813&rft_id=info:doi/10.1038%2Fsj.ejhg.5201756 LA - English DB - ProQuest Central N1 - Copyright - Copyright Nature Publishing Group Mar 2007 N1 - Last updated - 2014-04-10 DO - http://dx.doi.org/10.1038/sj.ejhg.5201756 ER - TY - JOUR T1 - Rapid Clearance of Lyme Disease Spirochetes Lacking OspC from Skin AN - 20989378; 7287822 AB - We previously demonstrated that Borrelia burgdorferi requires OspC to colonize a mammalian host. To delineate this requirement, we analyzed the clearance of ospC mutant spirochetes and found that they were eliminated within 48 h. We conclude that B. burgdorferi uses OspC to resist innate host defenses immediately after transmission. JF - Infection and Immunity AU - Tilly, Kit AU - Bestor, Aaron AU - Jewett, Mollie W AU - Rosa, Patricia AD - Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1517 EP - 1519 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 3 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Spirochetes KW - Borrelia burgdorferi KW - Lyme disease KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20989378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Rapid+Clearance+of+Lyme+Disease+Spirochetes+Lacking+OspC+from+Skin&rft.au=Tilly%2C+Kit%3BBestor%2C+Aaron%3BJewett%2C+Mollie+W%3BRosa%2C+Patricia&rft.aulast=Tilly&rft.aufirst=Kit&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1517&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Spirochetes; Lyme disease; Borrelia burgdorferi ER - TY - JOUR T1 - Diversity and Distribution of Borrelia hermsii AN - 20928948; 7828882 AB - Borrelia hermsli is the most common cause of tickborne relapsing fever in North America. DNA sequences of the 16S-23S rDNA noncoding intergenic spacer (IGS) region were determined for 37 isolates of this spirochete. These sequences distinguished the 2 genomic groups of B. hermsii identified previously with other loci. Multiple IGS genotypes were identified among isolates from an island, which suggested that birds might play a role in dispersing these spirochetes in nature. In support of this theory, all stages of the tick vector Ornithodoros hermsi fed successfully on birds in the laboratory and advanced in their life cycle. B. hermsii produced a detectable spirochetemia in 1 chicken inoculated subcutaneously. Additional work is warranted to explore the role of birds as enzootic hosts for this relapsing fever spirochete. JF - Emerging Infectious Diseases AU - Schwan, T G AU - Raffel, S J AU - Schrumpf, ME AU - Porcella, S F AD - National Institute of Allergy and Infectious Diseases, Hamilton, Montana, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 VL - 13 IS - 3 SN - 1080-6040, 1080-6040 KW - Entomology Abstracts; Microbiology Abstracts B: Bacteriology KW - Borrelia hermsii KW - Ixodidae KW - Relapsing fever KW - Nucleotide sequence KW - Vectors KW - Life cycle KW - Spacer KW - Genotypes KW - Spirochetes KW - Islands KW - genomics KW - Ornithodoros KW - J 02410:Animal Diseases KW - Z 05360:Genetics and Evolution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20928948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Diversity+and+Distribution+of+Borrelia+hermsii&rft.au=Schwan%2C+T+G%3BRaffel%2C+S+J%3BSchrumpf%2C+ME%3BPorcella%2C+S+F&rft.aulast=Schwan&rft.aufirst=T&rft.date=2007-03-01&rft.volume=13&rft.issue=3&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Spirochetes; Islands; Nucleotide sequence; Relapsing fever; Life cycle; Vectors; Spacer; Genotypes; genomics; Borrelia hermsii; Ixodidae; Ornithodoros ER - TY - JOUR T1 - Mouse lung CYP1A1 catalyzes the metabolic activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) AN - 20796677; 7314945 AB - 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) carcinogenesis is initiated by N super(2)-hydroxylation, mediated by several cytochromes P450, including CYP1A1. However, the role of CYP1A1 in PhIP metabolic activation in vivo is unclear. In this study, Cyp1a1-null and wild-type (WT) mice were used to investigate the potential role of CYP1A1 in PhIP metabolic activation in vivo. PhIP N super(2)-hydroxylation was actively catalyzed by lung homogenates of WT mice, at a rate of 14.9 plus or minus 5.0 pmol/min/g tissue, but <1 pmol/min/g tissue in stomach and small intestine, and almost undetectable in mammary gland and colon. PhIP N super(2)-hydroxylation catalyzed by lung homogenates of Cyp1a1-null mice was similar to 10-fold lower than that of WT mice. In contrast, PhIP N super(2)-hydroxylation activity in lung homogenates of Cyp1a2-null versus WT mice was not decreased. Pretreatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin increased lung Cyp1a1 mRNA and lung homogenate PhIP N super(2)-hydroxylase activity similar to 50-fold in WT mice, where the activity was substantially inhibited (70%) by monoclonal antibodies against CYP1A1. In vivo, 30 min after oral treatment with PhIP, PhIP levels in lung were similar to those in liver. After a single dose of 0.1 mg/kg [ super(14)C]PhIP, lung PhIP-DNA adduct levels in Cyp1a1-null mice, but not in Cyp1a2-null mice, were significantly lower (P = 0.0028) than in WT mice. These results reveal that mouse lung has basal and inducible PhIP N super(2)-hydroxylase activity predominantly catalyzed by CYP1A1. Because of the high inducibility of human CYP1A1, especially in cigarette smokers, the role of lung CYP1A1 in PhIP carcinogenesis should be considered. (237 words). JF - Carcinogenesis AU - Ma, Xiaochao AU - Idle, Jeffrey R AU - Malfatti, Michael A AU - Krausz, Kristopher W AU - Nebert, Daniel W AU - Chen, Chong-Sheng AU - Felton, James S AU - Waxman, David J AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 3106 Bethesda, MD 20892, USA. Institute of Pharmacology, 1st Faculty of Medicine, Charles University 12800 Praha 2, Czech Republic. Biosciences Directorate, Lawrence Livermore National Laboratory Livermore, CA 94551, USA. Department of Environmental Health, University of Cincinnati Medical Center Cincinnati, OH 45267, USA. Department of Biology, Boston University Boston, MA 02215, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 732 EP - 737 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Cigarettes KW - Monoclonal antibodies KW - Mammary gland KW - Adducts KW - Small intestine KW - mRNA KW - Colon KW - Lung KW - Carcinogenesis KW - Liver KW - Metabolic activation KW - Cytochrome P450 KW - Stomach KW - N 14830:RNA KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20796677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Mouse+lung+CYP1A1+catalyzes+the+metabolic+activation+of+2-amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5Dpyridine+%28PhIP%29&rft.au=Ma%2C+Xiaochao%3BIdle%2C+Jeffrey+R%3BMalfatti%2C+Michael+A%3BKrausz%2C+Kristopher+W%3BNebert%2C+Daniel+W%3BChen%2C+Chong-Sheng%3BFelton%2C+James+S%3BWaxman%2C+David+J%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cigarettes; Mammary gland; Monoclonal antibodies; Adducts; Small intestine; mRNA; Colon; Lung; Carcinogenesis; Liver; Metabolic activation; Cytochrome P450; Stomach ER - TY - JOUR T1 - Differences in Risk Factors for Breast Cancer Molecular Subtypes in a Population-Based Study AN - 20727640; 7314986 AB - Analysis of gene expression data suggests that breast cancers are divisible into molecular subtypes which have distinct clinical features. This study evaluates whether pathologic features and etiologic associations differ among molecular subtypes. We evaluated 804 women with invasive breast cancers and 2,502 controls participating in a Polish Breast Cancer Study. Immunohistochemical stains for estrogen receptor alpha , progesterone receptor, human epidermal growth factor receptors (HER2 and HER1), and cytokeratin 5 were used to classify cases into five molecular subtypes: luminal A, luminal B, HER2-expresing, basal-like, and unclassified. Relative risks were estimated using adjusted odds ratios and 95% confidence intervals. We observed that compared with the predominant luminal A tumors (69%), other subtypes were associated with unfavorable clinical features at diagnosis, especially HER2-expressing (8%) and basal-like (12%) tumors. Increasing body mass index significantly reduced the risk of luminal A tumors among premenopausal women (odds ratios, 0.71; 95% confidence intervals, 0.57-0.88 per five-unit increase), whereas it did not reduce risk for basal-like tumors (1.18; 0.86-1.64; P sub(heterogeneity) = 0.003). On the other hand, reduced risk associated with increasing age at menarche was stronger for basal-like (0.78; 0.68-0.89 per 2-year increase) than luminal A tumors (0.90; 0.95-1.08; P sub(heterogeneity) = 0.0009). Although family history increased risk for all subtypes (except for unclassified tumors), the magnitude of the relative risk was highest for basal-like tumors. Results from this study have shown that breast cancer risk factors may vary by molecular subtypes identified in expression studies, suggesting etiologic, in addition to clinical, heterogeneity of breast cancer. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):439-43) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Yang, Xiaohong R AU - Sherman, Mark E AU - Rimm, David L AU - Lissowska, Jolanta AU - Brinton, Louise A AU - Peplonska, Beata AU - Hewitt, Stephen M AU - Anderson, William F AU - Szeszenia-Dabrowska, Neonila AU - Bardin-Mikolajczak, Alicja AU - Zatonski, Witold AU - Cartun, Richard AU - Mandich, Daniza AU - Rymkiewicz, Grzegorz AU - Ligaj, Marcin AU - Lukaszek, Stanislaw AU - Kordek, Radzisaw AU - Garcia-Closas, Montserrat AD - Division of Cancer Epidemiology and Genetics, Tissue Array Research Program, Laboratory of Pathology, Center For Cancer Research, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 439 EP - 443 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - risk reduction KW - Genetics KW - Age KW - body mass KW - prevention KW - Breast cancer KW - tumors KW - growth factors KW - Cancer KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Differences+in+Risk+Factors+for+Breast+Cancer+Molecular+Subtypes+in+a+Population-Based+Study&rft.au=Yang%2C+Xiaohong+R%3BSherman%2C+Mark+E%3BRimm%2C+David+L%3BLissowska%2C+Jolanta%3BBrinton%2C+Louise+A%3BPeplonska%2C+Beata%3BHewitt%2C+Stephen+M%3BAnderson%2C+William+F%3BSzeszenia-Dabrowska%2C+Neonila%3BBardin-Mikolajczak%2C+Alicja%3BZatonski%2C+Witold%3BCartun%2C+Richard%3BMandich%2C+Daniza%3BRymkiewicz%2C+Grzegorz%3BLigaj%2C+Marcin%3BLukaszek%2C+Stanislaw%3BKordek%2C+Radzisaw%3BGarcia-Closas%2C+Montserrat&rft.aulast=Yang&rft.aufirst=Xiaohong&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Genetics; risk reduction; Age; body mass; prevention; Breast cancer; tumors; growth factors; Cancer; estrogens ER - TY - JOUR T1 - Human stem cells, chromatin, and tissue engineering: Boosting relevancy in developmental toxicity testing AN - 20639106; 7596939 AB - Risk assessment derives its confidence from toxicology research that is based on relevancy to human health. This article focuses on two highly topical areas of current scientific research, stem cells and chromatin biology, which present new avenues for preclinical and clinical applications, and the frontier role of tissue engineering and regeneration. Appreciating the utility and necessity of chromatin and human somatic stem cells as research tools and looking toward tissue engineering may close the uncertainty gaps between animal and human cross-species toxicology evaluations. The focus will be on developmental toxicology applications, but appropriate extrapolation to any other areas of toxicology can be made. We further provide background on basic biology of these three areas and examples of how early life exposure to known and potential environmental toxicants induce malformations, childhood and adult-onset diseases, through aberrant chromatin modification of critical gene expressions (acute lymphocyte leukemia, heavy-metal nickel and cadmium-associated defects, and reproductive tract malformations and carcinomas induced by the synthetic estrogen, diethylstilbestrol). Birth Defects Research (Part C) 81:20-40, 2007. JF - Birth Defects Research Part C: Embryo Today: Reviews AU - Cho, Elizabeth AU - Li, Wan-Ju AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, chofertikh@hotmail.com Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 20 EP - 40 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 81 IS - 1 SN - 1542-975X, 1542-975X KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Estrogens KW - Toxicants KW - Chromatin KW - Nickel KW - Lymphocytes KW - Tissue engineering KW - Children KW - Carcinoma KW - Gene expression KW - Leukemia KW - Stem cells KW - Congenital defects KW - Embryos KW - Diethylstilbestrol KW - Toxicity testing KW - W 30920:Tissue Engineering KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20639106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Human+stem+cells%2C+chromatin%2C+and+tissue+engineering%3A+Boosting+relevancy+in+developmental+toxicity+testing&rft.au=Cho%2C+Elizabeth%3BLi%2C+Wan-Ju&rft.aulast=Cho&rft.aufirst=Elizabeth&rft.date=2007-03-01&rft.volume=81&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20087 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Estrogens; Chromatin; Toxicants; Nickel; Lymphocytes; Children; Tissue engineering; Carcinoma; Gene expression; Leukemia; Stem cells; Congenital defects; Embryos; Diethylstilbestrol; Toxicity testing DO - http://dx.doi.org/10.1002/bdrc.20087 ER - TY - JOUR T1 - Challenges and Solutions in Proteomics AN - 20424300; 7731262 AB - The accelerated growth of proteomics data presents both opportunities and challenges. Large-scale proteomic profiling of biological samples such as cells, organelles or biological fluids has led to discovery of numerous key and novel proteins involved in many biological/disease processes including cancers, as well as to the identification of novel disease biomarkers and potential therapeutic targets. While proteomic data analysis has been greatly assisted by the many bioinformatics tools developed in recent years, a careful analysis of the major steps and flow of data in a typical highthroughput analysis reveals a few gaps that still need to be filled to fully realize the value of the data. To facilitate functional and pathway discovery for large-scale proteomic data, we have developed an integrated proteomic expression analysis system, iProXpress, which facilitates protein identification using a comprehensive sequence library and functional interpretation using integrated data. With its modular design, iProXpress complements and can be integrated with other software in a proteomic data analysis pipeline. This novel approach to complex biological questions involves the interrogation of multiple data sources, thereby facilitating hypothesis generation and knowledge discovery from the genomic-scale studies and fostering disease diagnosis and drug development. JF - Current Genomics AU - Huang, H AU - Shukla, H D AU - Wu, C AU - Saxena, S AD - Proteomics and Mass Spectrometry Unit, Research Resources Branch, National Institute on Aging, National Institutes of Health, 333 Cassell Dr., Baltimore, MD 21224, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 21 EP - 28 VL - 8 IS - 1 SN - 1389-2029, 1389-2029 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Computer programs KW - software KW - Data processing KW - Drug development KW - proteomics KW - Bioinformatics KW - Organelles KW - biomarkers KW - Cancer KW - W 30960:Bioinformatics & Computer Applications KW - G 07700:Molecular Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20424300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Genomics&rft.atitle=Challenges+and+Solutions+in+Proteomics&rft.au=Huang%2C+H%3BShukla%2C+H+D%3BWu%2C+C%3BSaxena%2C+S&rft.aulast=Huang&rft.aufirst=H&rft.date=2007-03-01&rft.volume=8&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Current+Genomics&rft.issn=13892029&rft_id=info:doi/10.2174%2F138920207780076910 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; software; Data processing; Drug development; Bioinformatics; proteomics; Organelles; biomarkers; Cancer DO - http://dx.doi.org/10.2174/138920207780076910 ER - TY - JOUR T1 - Diurnal temperature range and daily mortality in Shanghai, China AN - 20389094; 7291019 AB - Although the relationship between temperature level and mortality outcomes has been well established, it is still unknown whether within-day variation in temperature, e.g. diurnal temperature range (DTR), is a risk factor for death independent of the corresponding temperature. Moreover, DTR is a meteorological indicator associated with global climate change which may be related to a variety of health outcomes. We hypothesized that large diurnal temperature change might be a source of additional environmental stress and therefore a risk factor for death. We used daily weather and mortality data from Shanghai, China to test this hypothesis. We conducted a time-series study to examine the association between DTR and mortality outcomes from 2001 to 2004. A semi-parametric generalized additive model (GAM) was used to assess the acute effect of DTR on mortality after controlling for covariates including time trend, day of the week (DOW), temperature, humidity, and outdoor air pollution. We found a strong association between DTR and daily mortality after adjustment for those potential confounders. A 1 super(o)C increment of the 3-day moving average of DTR corresponded to a 1.37% (95% CI 1.08-1.65%) increase in total non-accidental mortality, a 1.86% (95% CI 1.40-2.32%) increase in cardiovascular mortality, and a 1.29% (95% CI 0.49-2.09%) increase in respiratory mortality. The effects of DTR on total non-accidental and cardiovascular mortality were significant on both ''cold'' (below 23 super(o)C) and ''warm'' (at least 23 super(o)C) days, although respiratory mortality was only significantly associated with DTR on ''cold'' days. This study suggests within-day variation in temperature may be a novel risk factor for death. Diseases Diseases Prevention JF - Environmental Research AU - Kan, H AU - London, S J AU - Chen, H AU - Song, G AU - Chen, G AU - Jiang, L AU - Zhao, N AU - Zhang, Y AU - Chen, B AD - School of Public Health, Fudan University, Shanghai 200032, China, kanh@niehs.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 424 EP - 431 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 103 IS - 3 SN - 0013-9351, 0013-9351 KW - Meteorological & Geoastrophysical Abstracts; Pollution Abstracts; Sustainability Science Abstracts; Health & Safety Science Abstracts KW - Mortality due to atmospheric pollution KW - Mortality KW - Diurnal variations KW - Weather KW - Atmospheric pollution models KW - Climatic changes KW - Climate change KW - Temperature KW - Atmospheric pollution effects KW - Humidity KW - Environmental research KW - Diurnal temperature KW - Air pollution KW - Diurnal temperature range KW - environmental stress KW - Meteorology KW - Temperature trends KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Daily weather KW - M2 551.583:Variations (551.583) KW - M3 1010:Issues in Sustainable Development KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20389094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addictive+behaviors&rft.atitle=Alcohol+use+and+tobacco+abstinence+among+adolescents+in+cessation+treatment%3A+preliminary+findings.&rft.au=Jaszyna-Gasior%2C+Maria%3BSchroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Jaszyna-Gasior&rft.aufirst=Maria&rft.date=2007-03-01&rft.volume=32&rft.issue=3&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Addictive+behaviors&rft.issn=03064603&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality due to atmospheric pollution; Diurnal temperature range; Atmospheric pollution models; Climate change; Atmospheric pollution effects; Humidity; Environmental research; Temperature trends; Daily weather; Diurnal temperature; Air pollution; Weather; Diurnal variations; Mortality; environmental stress; Climatic changes; Temperature; Meteorology; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1016/j.envres.2006.11.009 ER - TY - JOUR T1 - Complement levels and activity in the normal and LPS-injured lung AN - 20325218; 7314049 AB - Complement, a complex protein system, plays an essential role in host defense through bacterial lysis, stimulation of phagocytosis, recruitment of immune cells to infected tissue, and promotion of the inflammatory response. Although complement is most well-characterized in serum, complement activity is also present in the lung. Here we further characterize the complement system in the normal and inflamed lung. By Western blot, C5, C6, and factor I were detected in bronchoalveolar lavage (BAL) at lower levels than in serum, whereas C2 was detected at similar levels in BAL and serum. C4 binding protein (C4BP) was not detectable in BAL. Exposure to lipopolysaccharide (LPS) elevated levels of C1q, factor B, C2, C4, C5, C6, and C3 in human BAL and C3, C5, and factor B in mouse and rat BAL. Message for C1q-B, C1r, C1s, C2, C4, C3, C5, C6, factor B, and factor H, but not C9 or C4BP, was readily detectable by RT-PCR in normal mouse lung. Exposure to LPS enhanced factor B expression, decreased C5 expression, and did not affect C1q-B expression in mouse and rat lung. BAL from rats exposed to LPS had a greater ability to deposit C3b onto bacteria through complement activation than did BAL from control rats. In summary, these data demonstrate that complement levels, expression, and function are altered in acute lung injury and suggest that complement within the lung is regulated to promote opsonization of pathogens and limit potentially harmful inflammation. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Bolger, Molly S AU - Ross, DeAndre S AU - Jiang, Haixiang AU - Frank, Michael M AU - Ghio, Andrew J AU - Schwartz, David A AU - Wright, Jo Rae AD - Departments of Cell Biology and Pediatrics, Duke University Medical Center, Durham, Human Studies Division, Environmental Protection Agency, Chapel Hill, and the National Institute of Environmental Health Sciences and National Toxicology Program, Durham, North Carolina Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - L748 EP - L759 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 292 IS - 3 SN - 1040-0605, 1040-0605 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Deposits KW - Western blotting KW - Data processing KW - Injuries KW - Complement component C1q KW - Complement factor H KW - complement component C4 KW - Pathogens KW - Alveoli KW - Inflammation KW - Bronchus KW - Complement component C3b KW - Lung KW - Complement activation KW - Polymerase chain reaction KW - Lipopolysaccharides KW - Complement component C3 KW - Phagocytosis KW - Opsonization KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20325218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=Complement+levels+and+activity+in+the+normal+and+LPS-injured+lung&rft.au=Bolger%2C+Molly+S%3BRoss%2C+DeAndre+S%3BJiang%2C+Haixiang%3BFrank%2C+Michael+M%3BGhio%2C+Andrew+J%3BSchwartz%2C+David+A%3BWright%2C+Jo+Rae&rft.aulast=Bolger&rft.aufirst=Molly&rft.date=2007-03-01&rft.volume=292&rft.issue=3&rft.spage=L748&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Western blotting; Deposits; Data processing; Injuries; Complement component C1q; Complement factor H; Pathogens; complement component C4; Alveoli; Inflammation; Complement component C3b; Bronchus; Lung; Complement activation; Lipopolysaccharides; Polymerase chain reaction; Complement component C3; Phagocytosis; Opsonization ER - TY - JOUR T1 - Investigating subsumption in SNOMED CT: An exploration into large description logic-based biomedical terminologies AN - 20267550; 7497172 AB - Objective: Formalisms based on one or other flavor of description logic (DL) are sometimes put forward as helping to ensure that terminologies and controlled vocabularies comply with sound ontological principles. The objective of this paper is to study the degree to which one DL-based biomedical terminology (SNOMED CT) does indeed comply with such principles. Materials and methods: We defined seven ontological principles (for example: each class must have at least one parent, each class must differ from its parent) and examined the properties of SNOMED CT classes with respect to these principles. Results: Our major results are 31% of these classes have a single child; 27% have multiple parents; 51% do not exhibit any differentiae between the description of the parent and that of the child. Conclusions: The applications of this principles to quality assurance for ontologies are discussed and suggestions are made for dealing with the phenomenon of multiple inheritance. The advantages and limitations of our approach are also discussed. JF - Artificial Intelligence in Medicine AU - Bodenreider, O AU - Smith, B AU - Kumar, A AU - Burgun, A AD - National Institutes of Health, Bethesda, MD, USA, olivier@nlm.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 183 EP - 195 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 0933-3657, 0933-3657 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20267550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Intelligence+in+Medicine&rft.atitle=Investigating+subsumption+in+SNOMED+CT%3A+An+exploration+into+large+description+logic-based+biomedical+terminologies&rft.au=Bodenreider%2C+O%3BSmith%2C+B%3BKumar%2C+A%3BBurgun%2C+A&rft.aulast=Bodenreider&rft.aufirst=O&rft.date=2007-03-01&rft.volume=39&rft.issue=3&rft.spage=183&rft.isbn=&rft.btitle=&rft.title=Artificial+Intelligence+in+Medicine&rft.issn=09333657&rft_id=info:doi/10.1016%2Fj.artmed.2006.12.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computed tomography DO - http://dx.doi.org/10.1016/j.artmed.2006.12.003 ER - TY - JOUR T1 - Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling AN - 20226231; 7314859 AB - Adoptive cell transfer (ACT) of tumor-reactive lymphocytes has been shown to be an effective treatment for cancer patients. Studies in murine models of ACT indicated that antitumor efficacy of adoptively transferred T cells is dependent on the differentiation status of the cells, with lymphocyte differentiation inversely correlated with in vivo antitumor effectiveness. T-cell in vitro development technologies provide a new opportunity to generate naive T cells for the purpose of ACT. In this study, we genetically modified human umbilical cord blood-derived hematopoietic stem cells (HSCs) to express tumor antigen-specific T-cell receptor (TCR) genes and generated T lymphocytes by coculture with a murine cell line expressing Notch-1 ligand, Delta-like-1 (OP9-DL1). Input HSCs were differentiated into T cells as evidenced by the expression of T-cell markers, such as CD7, CD1a, CD4, CD8, and CD3, and by detection of TCR excision circles. We found that such in vitro differentiated T cells expressed the TCR and showed HLA-A2-restricted, specific recognition and killing of tumor antigen peptide-pulsed antigen-presenting cells but manifested additional natural killer cell-like killing of tumor cell lines. The genetic manipulation of HSCs has broad implications for ACT of cancer. [Cancer Res 2007; 67(6):2425-9] JF - Cancer Research AU - Zhao, Yangbing AU - Parkhurst, Maria R AU - Zheng, Zhili AU - Cohen, Cyrille J AU - Riley, John P AU - Gattinoni, Luca AU - Restifo, Nicholas P AU - Rosenberg, Steven A AU - Morgan, Richard A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2425 EP - 2429 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Histocompatibility antigen HLA KW - T-cell receptor KW - double prime T-cell receptor KW - Natural killer cells KW - Animal models KW - Tumors KW - CD8 antigen KW - Umbilical cord KW - Cancer KW - Notch protein KW - Differentiation KW - Blood KW - Tumor cell lines KW - CD4 antigen KW - Stem cells KW - CD7 antigen KW - Genetic engineering KW - Antigen (tumor-associated) KW - Lymphocytes T KW - Antigen-presenting cells KW - CD3 antigen KW - Antitumor activity KW - Signal transduction KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Extrathymic+Generation+of+Tumor-Specific+T+Cells+from+Genetically+Engineered+Human+Hematopoietic+Stem+Cells+via+Notch+Signaling&rft.au=Zhao%2C+Yangbing%3BParkhurst%2C+Maria+R%3BZheng%2C+Zhili%3BCohen%2C+Cyrille+J%3BRiley%2C+John+P%3BGattinoni%2C+Luca%3BRestifo%2C+Nicholas+P%3BRosenberg%2C+Steven+A%3BMorgan%2C+Richard+A&rft.aulast=Zhao&rft.aufirst=Yangbing&rft.date=2007-03-01&rft.volume=67&rft.issue=6&rft.spage=2425&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histocompatibility antigen HLA; T-cell receptor; double prime T-cell receptor; Animal models; Natural killer cells; CD8 antigen; Tumors; Cancer; Umbilical cord; Notch protein; Blood; Differentiation; CD7 antigen; Stem cells; CD4 antigen; Tumor cell lines; Genetic engineering; Antigen (tumor-associated); Lymphocytes T; CD3 antigen; Antigen-presenting cells; Signal transduction; Antitumor activity ER - TY - JOUR T1 - Concentration-Dependent Effects of Caspofungin on the Metabolic Activity of Aspergillus Species AN - 19986510; 7285349 AB - The minimum effective concentration (MEC) used to assess the in vitro antifungal activity of caspofungin against Aspergillus spp. is a qualitative endpoint requiring microscopic examination of hyphae. We therefore developed a tool for the quantitative assessment of caspofungin activity against Aspergillus spp. at clinically applicable concentrations. Susceptibility to caspofungin (0.008 to 8 mu g/ml) was studied for 9 A. fumigatus, 8 A. flavus, and 12 A. terreus isolates based on the Clinical and Laboratory Standards Institute M38-A protocol. After 48 h of incubation, the MEC was defined microscopically, and metabolic activity assessed with a modified XTT assay, using 100 mu g of the tetrazolium salt XTT/ml and 6.25 mu M menadione. A significant reduction in metabolic activity was demonstrated at the MEC (0.25 to 0.5 mu g/ml) for all Aspergillus spp. and was more pronounced for A. flavus (median metabolic activity, 25% of control) compared to A. fumigatus and A. terreus (median metabolism, 42 and 53%, respectively), allowing determination of MEC with the XTT assay (93 to 100% agreement with microscopic MEC). Fungal metabolism tended to reach the lowest levels (median, 17 to 38% of control) one to two dilutions higher than the MEC, at the minimum metabolic activity concentration (MMC). For 5 of 9 A. fumigatus isolates, 6 of 12 A. terreus isolates, and 1 of 8 A. flavus isolates, a paradoxical increase in metabolism was observed at concentrations greater than the MMC. Sigmoid (E sub(max)) or bell-shaped models described accurately (median R super(2) = 0.97) the concentration-dependent metabolic changes in the absence or presence, respectively, of paradoxical response. Assessment of metabolic activity may provide useful quantitative endpoints for in vitro studies of caspofungin against Aspergillus spp. JF - Antimicrobial Agents & Chemotherapy AU - Antachopoulos, Charalampos AU - Meletiadis, Joseph AU - Sein, Tin AU - Roilides, Emmanuel AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Third Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 881 EP - 887 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Aspergillus flavus KW - tetrazolium salt KW - Caspofungin KW - Antifungal activity KW - Hyphae KW - Menadione KW - Aspergillus KW - Metabolism KW - Antimicrobial agents KW - Models KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Concentration-Dependent+Effects+of+Caspofungin+on+the+Metabolic+Activity+of+Aspergillus+Species&rft.au=Antachopoulos%2C+Charalampos%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2007-03-01&rft.volume=196&rft.issue=3&rft.spage=259.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - tetrazolium salt; Hyphae; Antifungal activity; Caspofungin; Menadione; Metabolism; Models; Antimicrobial agents; Aspergillus flavus; Aspergillus ER - TY - JOUR T1 - Risk of second malignant neoplasms among lymphoma patients with a family history of cancer AN - 19980453; 8079257 AB - Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL) (n = 25,941), or chronic lymphocytic leukemia (CLL) (n = 7,764), using a large population-based database. Family history of cancer was based on a diagnosis of any cancer in 110,862 first-degree relatives. We found increased relative risk (RR) (1.81, 95% confidence interval (CI): 1.04-3.16) of breast cancer among HL patient with positive (vs. negative) family history of cancer. Among CLL patients with positive (vs. negative) family history of cancer, we observed elevated risks of bladder (RR = 3.53, 95% CI: 1.31-9.55) and prostate cancer (RR = 2.15, 95% CI: 1.17-3.94). For NHL patients with positive (vs. negative) family history of cancer, we observed non-significantly increased risk of non-melanoma skin cancer (RR = 1.94, 95% CI: 0.86-4.38) and lung cancer (RR = 1.99, 95% CI: 0.73-5.39). Our observations suggest that genetic factors, as measured by positive family history of cancer, may be influential risk-factors for selected second tumors following lymphoproliferative disorders. JF - International Journal of Cancer AU - Landgren, Ola AU - Pfeiffer, Ruth M AU - Stewart, Laveta AU - Gridley, Gloria AU - Mellemkjaer, Lene AU - Hemminki, Kari AU - Goldin, Lynn R AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, landgreo@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1099 EP - 1102 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 120 IS - 5 SN - 0020-7136, 0020-7136 KW - Immunology Abstracts; Risk Abstracts KW - Genetic factors KW - Skin KW - Hodgkin's disease KW - Urinary bladder KW - Chemotherapy KW - Skin cancer KW - Radiotherapy KW - Tumors KW - radiotherapy KW - chemotherapy KW - Immunoproliferative diseases KW - Genetics KW - Leukemia KW - Databases KW - Prostate cancer KW - Risk factors KW - Breast cancer KW - prostate cancer KW - lymphoma KW - Chronic lymphatic leukemia KW - Lung cancer KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Risk+of+second+malignant+neoplasms+among+lymphoma+patients+with+a+family+history+of+cancer&rft.au=Landgren%2C+Ola%3BPfeiffer%2C+Ruth+M%3BStewart%2C+Laveta%3BGridley%2C+Gloria%3BMellemkjaer%2C+Lene%3BHemminki%2C+Kari%3BGoldin%2C+Lynn+R%3BTravis%2C+Lois+B&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2007-03-01&rft.volume=120&rft.issue=5&rft.spage=1099&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Genetic factors; Hodgkin's disease; Urinary bladder; Chemotherapy; Radiotherapy; Skin cancer; Tumors; Immunoproliferative diseases; Databases; Prostate cancer; Risk factors; Breast cancer; Chronic lymphatic leukemia; Lung cancer; Leukemia; Genetics; Skin; prostate cancer; radiotherapy; lymphoma; chemotherapy DO - http://dx.doi.org/10.1002/ijc.22414 ER - TY - JOUR T1 - Expression of Immunomodulatory Genes in Human Monocytes Induced by Voriconazole in the Presence of Aspergillus fumigatus AN - 19967253; 7285316 AB - We assessed the effect of voriconazole (VRC) on the expression and release of selected cytokines and chemokines in the THP-1 human monocytic cell line in response to Aspergillus fumigatus hyphal fragments (HF) by cDNA microarray analysis, reverse transcriptase (RT) PCR, and enzyme-linked immunosorbent assay. Stimulation of THP-1 cells by HF alone caused a significant up-regulation of CCL4 (MIP1B) and CCL16, while CCL2 (MCP1) was down-regulated. By comparison, in the presence of VRC, a large number of genes such as CCL3 (MIP1A), CCL4 (MIP1B), CCL5 (RANTES), CCL7 (MCP3), CCL11 (EOTAXIN), CCL15 (MIP1 Delta ), CXCL6, and CXCL13 were strongly up-regulated in THP-1 cells challenged by HF, whereas CCL20 (MIP3A) and CCL21 (MIP2) were down-regulated. Among five genes differentially expressed in THP-1 cells, IL12A, IL12B, and IL-16 were down-regulated whereas IL-11 and TGFB1 were significantly up-regulated in the presence of VRC. The inflammation-related genes IFN gamma , IL1R1, and TNFA were also up-regulated in THP-1 cells exposed to HF only in the presence of VRC. RT-PCR of four selected genes validated the results of microarrays. The release of interleukin 1{szligbeta} (IL-1{szligbeta}) and IL-12 was significantly increased from monocytes stimulated either by HF alone (P < 0.05) or in the presence of VRC (P < 0.01 and P < 0.05, respectively). In contrast, tumor necrosis factor alpha release from monocytes was enhanced only in the presence of VRC (P < 0.01). The chemokines monocyte chemoattractant protein 1 and macrophage inflammatory protein 1{szligbeta} were decreased under both conditions (P < 0.01). These results demonstrate that in the presence of VRC, HF induces a more pronounced profile of gene expression in THP-1 cells than HF alone, potentially leading to more-efficient host resistance to A. fumigatus. JF - Antimicrobial Agents & Chemotherapy AU - Simitsopoulou, M AU - Roilides, E AU - Likartsis, C AU - Ioannidis, J AU - Orfanou, A AU - Paliogianni, F AU - Walsh, T J AD - Laboratory of Infectious Diseases, 3rd Department of Pediatrics, School of Medicine, Aristotle University, Hippokration Hospital, Thessaloniki 54642, Greece. Laboratory of Medical Biotechnology, Department of Medical Laboratories, Technological Educational Institute of Thessaloniki, 57400 Thessaloniki, Greece. Immunocompromised Host Section, National Cancer Institute, Bethesda, Maryland 20892. Department of Microbiology, University of Patras Medical School, Patras 26500, Greece Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1048 EP - 1054 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 3 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Chemokines KW - CCL4 protein KW - Interleukin 1 KW - DNA microarrays KW - Immunomodulation KW - Interleukin 11 KW - Gene expression KW - Interleukin 12 KW - CXCL13 protein KW - Interleukin 16 KW - Voriconazole KW - Polymerase chain reaction KW - RNA-directed DNA polymerase KW - Cytokines KW - eotaxin KW - Monocytes KW - CCL20 protein KW - Transforming growth factor- beta 1 KW - Enzyme-linked immunosorbent assay KW - Monocyte chemoattractant protein 1 KW - CCL3 protein KW - RANTES KW - Antimicrobial agents KW - Aspergillus fumigatus KW - Chemotactic factors KW - Tumor necrosis factor- alpha KW - CCL21 protein KW - Macrophage inflammatory protein KW - A 01340:Antibiotics & Antimicrobials KW - K 03350:Immunology KW - F 06910:Microorganisms & Parasites KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Expression+of+Immunomodulatory+Genes+in+Human+Monocytes+Induced+by+Voriconazole+in+the+Presence+of+Aspergillus+fumigatus&rft.au=Simitsopoulou%2C+M%3BRoilides%2C+E%3BLikartsis%2C+C%3BIoannidis%2C+J%3BOrfanou%2C+A%3BPaliogianni%2C+F%3BWalsh%2C+T+J&rft.aulast=Simitsopoulou&rft.aufirst=M&rft.date=2007-03-01&rft.volume=51&rft.issue=3&rft.spage=1048&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chemokines; CCL4 protein; Interleukin 1; Immunomodulation; DNA microarrays; Gene expression; Interleukin 11; Interleukin 12; CXCL13 protein; Interleukin 16; Voriconazole; Cytokines; RNA-directed DNA polymerase; Polymerase chain reaction; eotaxin; Monocytes; CCL20 protein; Transforming growth factor- beta 1; Enzyme-linked immunosorbent assay; Monocyte chemoattractant protein 1; CCL3 protein; RANTES; Antimicrobial agents; Chemotactic factors; CCL21 protein; Tumor necrosis factor- alpha; Macrophage inflammatory protein; Aspergillus fumigatus ER - TY - JOUR T1 - Polychlorinated Biphenyls and Non-Hodgkin Lymphoma AN - 19962964; 7314974 AB - Several epidemiologic studies suggest that polychlorinated biphenyl (PCB) levels measured in peripheral blood or adipose tissue are related to increased risk of non-Hodgkin lymphoma (NHL) and, therefore, may be at least partially responsible for the rising incidence of NHL unrelated to HIV infection in recent decades. Case-control studies that measured PCBs in blood, adipose tissue, or household carpet dust, at the time of diagnosis, have observed elevated NHL risk associated with concentrations of either total PCBs or of specific congeners. Similar associations have been found in a number of prospective cohorts. These associations do not seem to be due to confounding by other organochlorines or by other known NHL risk factors. These results support evidence of PCB carcinogenicity from animal studies. However, interpretation of the epidemiologic evidence is limited by the wide range in measurement precision across congeners and by the moderate to high correlation among many congeners. Occupational cohort studies provide very limited support for a relationship between PCBs and NHL. In conclusion, there is mounting evidence of a relationship between certain PCBs and risk of NHL, but important questions remain, especially regarding the magnitude, timing, and causality of that relationship. (Cancer Epidemiol Biomarkers Prev 2007; 16(3):373-6) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Engel, Lawrence S AU - Lan, Qing AU - Rothman, Nathaniel AD - Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York and Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 373 EP - 376 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 3 SN - 1055-9965, 1055-9965 KW - HIV KW - Immunology Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Organochlorine compounds KW - adipose tissues KW - Infection KW - Dust KW - households KW - Carpets KW - Carcinogenicity KW - Risk factors KW - infection KW - prevention KW - Congeners KW - PCB compounds KW - Lymphoma KW - PCB KW - Bioindicators KW - Peripheral blood KW - biomarkers KW - Cancer KW - polychlorinated biphenyls KW - Human immunodeficiency virus KW - Adipose tissue KW - lymphoma KW - H 11000:Diseases/Injuries/Trauma KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962964?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Polychlorinated+Biphenyls+and+Non-Hodgkin+Lymphoma&rft.au=Engel%2C+Lawrence+S%3BLan%2C+Qing%3BRothman%2C+Nathaniel&rft.aulast=Engel&rft.aufirst=Lawrence&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=373&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Organochlorine compounds; Peripheral blood; Infection; biomarkers; Dust; Cancer; polychlorinated biphenyls; Carcinogenicity; Carpets; Risk factors; Congeners; Adipose tissue; Lymphoma; PCB; Bioindicators; households; prevention; infection; adipose tissues; lymphoma; PCB compounds; Human immunodeficiency virus ER - TY - JOUR T1 - Fragment complementation for the co-refolding of Thermotoga maritima beta -glucosidase by gene splitting at non-homologous region AN - 19887731; 7584166 AB - beta -Glucosidase from Thermotoga maritima is a 721 amino acid protein consisting of structurally distinct non-homologous region connecting the N- and C-terminal domains. To investigate the functional role of the non-homologous region in co-refolding, the gene was split at four sites (370, 403, 419 and 435) of the non-homologous region, cloned and separately expressed in E. coli generating eight peptide fragments (N370, N403, N419, N435, 371C, 404C, 420C and 436C). All eight fragments were recovered as insoluble inclusion bodies and found to be catalytically inactive. No catalytic activity was observed when these eight fragments were refolded individually. However, the catalytic activity was recovered when the two fragments derived from N- and C-terminal peptides were co-refolded together. Truncation of almost all amino acid residues in non-homologous region resulted in extremely low catalytic activity, which strongly suggests that non-homologous region is very important for the proper refolding of the peptides to reconstitute the catalytic activity. We succeeded in refolding the protein into an active form after splitting the gene at non-homologous region, denaturing and co-refolding the two domains. These results demonstrates the importance of structural elements that are not involved in the active site play an important role in protein folding to assemble the active site elements. JF - Enzyme and Microbial Technology AU - Kim, Bong-Jo AU - Mangala, Selanere L AU - Muralidhara, B K AU - Hayashi, Kiyoshi AD - Enzyme Laboratory, National Food Research Institute, 2-1-12 Kannondai, Tsukuba 305-8642, Japan, bjkim@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 732 EP - 739 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 4 SN - 0141-0229, 0141-0229 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; ASFA Marine Biotechnology Abstracts KW - beta -Glucosidase KW - Thermotoga maritima KW - Non-homologous region KW - Co-refolding KW - Gene splitting KW - Inclusion bodies KW - Fragment complementation KW - Amino acids KW - Complementation KW - Protein folding KW - Escherichia coli KW - Enzymes KW - Splitting KW - J 02310:Genetics & Taxonomy KW - G 07880:Human Genetics KW - Q4 27760:Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19887731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Enzyme+and+Microbial+Technology&rft.atitle=Fragment+complementation+for+the+co-refolding+of+Thermotoga+maritima+beta+-glucosidase+by+gene+splitting+at+non-homologous+region&rft.au=Kim%2C+Bong-Jo%3BMangala%2C+Selanere+L%3BMuralidhara%2C+B+K%3BHayashi%2C+Kiyoshi&rft.aulast=Kim&rft.aufirst=Bong-Jo&rft.date=2007-03-01&rft.volume=40&rft.issue=4&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=Enzyme+and+Microbial+Technology&rft.issn=01410229&rft_id=info:doi/10.1016%2Fj.enzmictec.2006.06.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Complementation; Amino acids; Protein folding; Enzymes; Inclusion bodies; beta -Glucosidase; Splitting; Escherichia coli; Thermotoga maritima DO - http://dx.doi.org/10.1016/j.enzmictec.2006.06.005 ER - TY - JOUR T1 - The Broad Antibacterial Activity of the Natural Antibody Repertoire Is Due to Polyreactive Antibodies AN - 19806733; 8569599 AB - Polyreactive antibodies bind to a variety of structurally unrelated antigens. The function of these antibodies, however, has remained an enigma, and because of their low binding affinity their biological relevance has been questioned. Using a panel of monoclonal polyreactive antibodies, we showed that these antibodies can bind to both Gram-negative and Gram-positive bacteria and acting through the classical complement pathway can inhibit bacterial growth by lysis, generate anaphylatoxin C5a, enhance phagocytosis, and neutralize the functional activity of endotoxin. Polyreactive antibody- enriched, but not polyreactive antibody-reduced, IgM prepared from normal human serum displays antibacterial activity similar to that of monoclonal polyreactive IgM. We conclude that polyreactive antibodies are a major contributor to the broad antibacterial activity of the natural antibody repertoire. JF - Cell Host & Microbe AU - Zhou, Zhao-Hua AU - Zhang, Yahong AU - Hu, Ya-Fang AU - Wahl, Larry M AU - Cisar, John O AU - Notkins, Abner Louis AD - Experimental Medicine Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, anotkins@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 51 EP - 61 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 1 IS - 1 SN - 1931-3128, 1931-3128 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - MICROBIO KW - CELLIMMUNO KW - MOLIMMUNO KW - Endotoxins KW - Anaphylatoxin C5a KW - Antibacterial activity KW - Monoclonal antibodies KW - Gram-positive bacteria KW - Phagocytosis KW - Immunoglobulin M KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19806733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Host+%26+Microbe&rft.atitle=The+Broad+Antibacterial+Activity+of+the+Natural+Antibody+Repertoire+Is+Due+to+Polyreactive+Antibodies&rft.au=Zhou%2C+Zhao-Hua%3BZhang%2C+Yahong%3BHu%2C+Ya-Fang%3BWahl%2C+Larry+M%3BCisar%2C+John+O%3BNotkins%2C+Abner+Louis&rft.aulast=Zhou&rft.aufirst=Zhao-Hua&rft.date=2007-03-01&rft.volume=27&rft.issue=2&rft.spage=1167&rft.isbn=&rft.btitle=&rft.title=Anticancer+research&rft.issn=02507005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Endotoxins; Anaphylatoxin C5a; Antibacterial activity; Monoclonal antibodies; Gram-positive bacteria; Phagocytosis; Immunoglobulin M DO - http://dx.doi.org/10.1016/j.chom.2007.01.002 ER - TY - JOUR T1 - Specialized mismatch repair function of Glu339 in the Phe-X-Glu motif of yeast Msh6 AN - 19794620; 7324938 AB - The major eukaryotic mismatch repair (MMR) pathway requires Msh2-Msh6, which, like Escherichia coli MutS, binds to and participates in repair of the two most common replication errors, single base-base and single base insertion-deletion mismatches. For both types of mismatches, the side chain of E. coli Glu38 in a conserved Phe-X-Glu motif interacts with a mismatched base. The O approximately equal to of Glu38 forms a hydrogen bond with either the N7 of purines or the N3 of pyrimidines. We show here that changing E. coli Glu38 to alanine results in nearly complete loss of repair of both single base-base and single base deletion mismatches. In contrast, a yeast strain with alanine replacing homologous Glu339 in Msh6 has nearly normal repair for insertion-deletion and most base-base mismatches, but is defective in repairing base-base mismatches characteristic of oxidative stress, e.g. 8-oxo-G.A mismatches. The results suggest that bacterial MutS and yeast Msh2-Msh6 differ in how they recognize and/or process replication errors involving undamaged bases, and that Glu339 in Msh6 may have a specialized role in repairing mismatches containing oxidized bases. JF - DNA Repair AU - Holmes, S F AU - Scarpinato, K D AU - McCulloch, S D AU - Schaaper, R M AU - Kunkel, T A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States, kunkel@niehs.nih.gov Y1 - 2007/03/01/ PY - 2007 DA - 2007 Mar 01 SP - 293 EP - 303 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 6 IS - 3 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Biochemistry Abstracts 2: Nucleic Acids KW - Gene deletion KW - mismatch repair KW - Alanine KW - Replication KW - Hydrogen bonding KW - Oxidative stress KW - Escherichia coli KW - pyrimidines KW - DNA repair KW - MSH6 protein KW - purines KW - N 14820:DNA Metabolism & Structure KW - J 02490:Miscellaneous KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Specialized+mismatch+repair+function+of+Glu339+in+the+Phe-X-Glu+motif+of+yeast+Msh6&rft.au=Holmes%2C+S+F%3BScarpinato%2C+K+D%3BMcCulloch%2C+S+D%3BSchaaper%2C+R+M%3BKunkel%2C+T+A&rft.aulast=Holmes&rft.aufirst=S&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2006.10.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene deletion; mismatch repair; Alanine; Oxidative stress; Hydrogen bonding; Replication; pyrimidines; DNA repair; purines; MSH6 protein; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2006.10.023 ER - TY - JOUR T1 - Psoralen Conjugates for Visualization of Genomic Interstrand Cross-Links Localized by Laser Photoactivation AN - 19788024; 7650982 AB - DNA interstrand cross-links are formed by chemotherapy drugs as well as by products of normal oxidative metabolism. Despite their importance, the pathways of cross-link metabolism are poorly understood. Laser confocal microscopy has become a powerful tool for studying the repair of DNA lesions that can be detected by immunofluorescent reagents. In order to apply this approach to cross-link repair, we have synthesized conjugates of 4,5',8-trimethylpsoralen (TMP) and easily detected compounds such as Lissamine rhodamine B sulfonyl chloride (LRB-SC), biotin, and digoxigenin. These conjugates are activated by UVA, and we have analyzed the intracellular localization of DNA damage and DNA reactivity by confocal and immunofluorescence microscopy. The LRB-SC-TMP conjugate 2 appeared mainly in the mitochondria, while the biotin-TMP conjugate 4 preferentially localized in the cytoplasm. Adducts formed by UVA and digoxigenin conjugates of TMP 7a and 4,5'-dimethylangelicin (DMA) 7b, which forms only monoadducts, were largely localized to the nucleus. Exposure of cells incubated with 7a and 7b to a 364 nm UV laser directed toward defined nuclear regions of interest resulted in localized adduct formation which could be visualized by immunofluorescence. Repair-proficient cells were able to remove the photoadducts, while repair-deficient cells were unable to repair the damage. The results indicated that the digoxigenin-TMP conjugate 7a and digoxigenin-DMA conjugate 7b can be used for studying the repair of laser localized DNA monoadducts and cross-links. JF - Bioconjugate Chemistry AU - Thazhathveetil, A K AU - Liu, S-T AU - Indig, F E AU - Seidman, M M AD - Laboratory of Molecular Gerontology, National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 431 EP - 437 VL - 18 IS - 2 SN - 1043-1802, 1043-1802 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Chemotherapy KW - Adducts KW - Digoxigenin KW - Mitochondria KW - Chloride KW - Immunofluorescence KW - DNA repair KW - psoralen KW - Oxidative metabolism KW - DNA damage KW - Cytoplasm KW - Confocal microscopy KW - Lasers KW - genomics KW - Photoactivation KW - Nuclei KW - Biotin KW - rhodamine KW - Drugs KW - G 07720:Immunogenetics KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19788024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Concentration-Dependent+Effects+of+Caspofungin+on+the+Metabolic+Activity+of+Aspergillus+Species&rft.au=Antachopoulos%2C+Charalampos%3BMeletiadis%2C+Joseph%3BSein%2C+Tin%3BRoilides%2C+Emmanuel%3BWalsh%2C+Thomas+J&rft.aulast=Antachopoulos&rft.aufirst=Charalampos&rft.date=2007-03-01&rft.volume=51&rft.issue=3&rft.spage=881&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Digoxigenin; Adducts; Chemotherapy; Mitochondria; Chloride; Immunofluorescence; DNA repair; psoralen; Oxidative metabolism; DNA damage; Cytoplasm; Confocal microscopy; Lasers; Photoactivation; genomics; Nuclei; Drugs; rhodamine; Biotin DO - http://dx.doi.org/10.1021/bc060309t ER - TY - JOUR T1 - Improved Antibacterial Host Defense and Altered Peripheral Granulocyte Homeostasis in Mice Lacking the Adhesion Class G Protein Receptor CD97 AN - 19782161; 7287780 AB - CD97 is a member of the adhesion family of G protein-coupled receptors. Alternatively spliced forms of CD97 bind integrins alpha 5{szligbeta}1 and alpha v{szligbeta}3, decay accelerating factor, or dermatan sulfate. CD97 is expressed on myeloid cells at high levels and a variety of other cell types at lower levels. Little is known about the physiological function of CD97. To begin dissecting the function of CD97, we evaluated the immune response of CD97 null mice to systemic infection by Listeria monocytogenes. CD97 null mice were significantly more resistant to listeriosis than matched wild-type mice. A major determinant of the difference in survival appeared to be the comparatively more robust accumulation of granulocytes in the blood and in infected livers of CD97 null mice within 18 h of inoculation, correlating with a decrease in the number of bacteria. CD97 null mice also displayed a mild granulocytosis in the nonchallenged state. Because there is a strong suggestion that CD97 functions in an adhesive capacity, we examined the migratory properties of granulocytes in CD97 null mice. In chimeric animals, CD97 null and wild-type granulocytes migrated similarly, as determined by inflammation-induced emigration from the bone marrow and accumulation in the peritoneum. Granulocyte development in the bone marrow of CD97 null mice was comparable to that of wild-type mice, and CD97 deficiency did not appear to stimulate granulocytosis secondary to peripheral inflammation and resultant granulocyte colony-stimulating factor induction, unlike various other models of adhesion deficiencies. Our results suggest that CD97 plays a role in peripheral granulocyte homeostasis. JF - Infection and Immunity AU - Wang, Tao AU - Tian, Linhua AU - Haino, Makoto AU - Gao, Ji-Liang AU - Lake, Ross AU - Ward, Yvona AU - Wang, Hongshan AU - Siebenlist, Ulrich AU - Murphy, Philip M AU - Kelly, Kathleen AD - Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute. Laboratory of Host Defenses. Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20878 Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1144 EP - 1153 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 3 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Listeriosis KW - Disseminated infection KW - Bone marrow KW - Animal models KW - Survival KW - Granulocyte colony-stimulating factor KW - Homeostasis KW - Myeloid cells KW - G protein-coupled receptors KW - Integrins KW - Cell migration KW - Adhesives KW - Listeria monocytogenes KW - double prime G protein-coupled receptors KW - Peritoneum KW - Guanine nucleotide-binding protein KW - Alternative splicing KW - Sulfate KW - Inflammation KW - Leukocytes (granulocytic) KW - Blood KW - Inoculation KW - Liver KW - decay-accelerating factor KW - Immune response KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19782161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Improved+Antibacterial+Host+Defense+and+Altered+Peripheral+Granulocyte+Homeostasis+in+Mice+Lacking+the+Adhesion+Class+G+Protein+Receptor+CD97&rft.au=Wang%2C+Tao%3BTian%2C+Linhua%3BHaino%2C+Makoto%3BGao%2C+Ji-Liang%3BLake%2C+Ross%3BWard%2C+Yvona%3BWang%2C+Hongshan%3BSiebenlist%2C+Ulrich%3BMurphy%2C+Philip+M%3BKelly%2C+Kathleen&rft.aulast=Wang&rft.aufirst=Tao&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Listeriosis; double prime G protein-coupled receptors; Disseminated infection; Peritoneum; Animal models; Bone marrow; Survival; Guanine nucleotide-binding protein; Homeostasis; Granulocyte colony-stimulating factor; Myeloid cells; Inflammation; Sulfate; Alternative splicing; Blood; Leukocytes (granulocytic); G protein-coupled receptors; Integrins; Liver; Inoculation; decay-accelerating factor; Cell migration; Immune response; Adhesives; Listeria monocytogenes ER - TY - JOUR T1 - Comparing two approaches for aligning representations of anatomy AN - 19706733; 7497175 AB - Objective: To analyze the comparison, through their results, of two distinct approaches applied to aligning two representations of anatomy. Materials: Both approaches use a combination of lexical and structural techniques. In addition, the first approach takes advantage of domain knowledge, while the second approach treats alignment as a special case of schema matching. The same versions of FMA and GALEN were aligned by each approach. Two thousand one hundred and ninety-nine concept matches were obtained by both approaches. Methods and results: For matches identified by one approach only (337 and 336, respectively), we analyzed the reasons that caused the other approach to fail. Conclusions: The first approach could be improved by addressing partial lexical matches and identifying matches based solely on structural similarity. The second approach may be improved by taking into account synonyms in FMA and identifying semantic mismatches. However, only 33% of the possible one-to-one matches among anatomical concepts were identified by the two approaches together. New directions need to be explored in order to handle more complex matches. JF - Artificial Intelligence in Medicine AU - Zhang, S AU - Mork, P AU - Bodenreider, O AU - Bernstein, P A AD - National Institutes of Health, Bethesda, MD, USA, smzhang@math.ac.cn Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 227 EP - 236 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 39 IS - 3 SN - 0933-3657, 0933-3657 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Language KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19706733?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Artificial+Intelligence+in+Medicine&rft.atitle=Comparing+two+approaches+for+aligning+representations+of+anatomy&rft.au=Zhang%2C+S%3BMork%2C+P%3BBodenreider%2C+O%3BBernstein%2C+P+A&rft.aulast=Zhang&rft.aufirst=S&rft.date=2007-03-01&rft.volume=39&rft.issue=3&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Artificial+Intelligence+in+Medicine&rft.issn=09333657&rft_id=info:doi/10.1016%2Fj.artmed.2006.12.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; Language; Semantics DO - http://dx.doi.org/10.1016/j.artmed.2006.12.002 ER - TY - JOUR T1 - Adolescents as victims of familial violence: a hospital based surveillance AN - 19668777; 7423937 AB - Adolescent abuse is an important and understudied issue in society. The objective of this study was to examine the epidemiology of physical injuries due to maltreatment among adolescents aged 10-19 years. Subjects came from seven hospitals/trauma centres in Washington DC that were involved in the Washington DC Initiative to Reduce Infant Mortality and Prevention of Childhood Injuries Study. From 1996-1998, information was gathered about all injuries to adolescents aged 10-19 years that resulted in a visit to a participating emergency department. This paper focuses on the subset 178 adolescents aged 10--19 years who presented with physical injuries due to maltreatment. It was found that 55% of victims of abuse were female. Abuse victims were more likely to be female than those with unintentional injury. The most common injuries were contusions to the extremities (29%). Mothers were the most common perpetrators (48%). A total of 64% of victims were assaulted with an object/weapon and the most common object used was a belt. There are some similarities and some important differences between patterns of maltreatment in adolescents vs. younger children. Increased awareness of maltreatment among older children is a critical step in increasing and improving screening and prevention practices among health-care professionals. JF - International Journal of Injury Control and Safety Promotion AU - Saluja, G AU - Marquez, V AU - Cheng, T L AU - Trumble, A AU - Brenner, R A AD - National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (DESPR/NICHD/NIH), 6100 Executive Blvd., Room 7B03, Bethesda, MD 20892-7510, USA, salujag@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 19 EP - 23 VL - 14 IS - 1 SN - 1745-7300, 1745-7300 KW - Health & Safety Science Abstracts KW - Weapons KW - Injuries KW - infant mortality KW - prevention KW - Children KW - extremities KW - Violence KW - Adolescents KW - Emergency medical services KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.atitle=Adolescents+as+victims+of+familial+violence%3A+a+hospital+based+surveillance&rft.au=Saluja%2C+G%3BMarquez%2C+V%3BCheng%2C+T+L%3BTrumble%2C+A%3BBrenner%2C+R+A&rft.aulast=Saluja&rft.aufirst=G&rft.date=2007-03-01&rft.volume=14&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Injury+Control+and+Safety+Promotion&rft.issn=17457300&rft_id=info:doi/10.1080%2F17457300601049618 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Weapons; infant mortality; Injuries; prevention; extremities; Children; Violence; Adolescents; Emergency medical services DO - http://dx.doi.org/10.1080/17457300601049618 ER - TY - JOUR T1 - snp.plotter: an R-based SNP/haplotype association and linkage disequilibrium plotting package AN - 19658088; 7404163 AB - SUMMARY: snp.plotter is a newly developed R package which produces high-quality plots of results from genetic association studies. The main features of the package include options to display a linkage disequilibrium (LD) plot below the P-value plot using either the r super(2) or D' LD metric, to set the X-axis to equal spacing or to use the physical map of markers, and to specify plot labels, colors, symbols and LD heatmap color scheme. snp.plotter can plot single SNP and/or haplotype data and simultaneously plot multiple sets of results. R is a free software environment for statistical computing and graphics available for most platforms. The proposed package provides a simple way to convey both association and LD information in a single appealing graphic for genetic association studies. AVAILABILITY: Downloadable R package and example datasets are available at http://cbdb.nimh.nih.gov/~kristin/snp.plotter.html and http://www.r-project.org CONTACT: nicodemuskail.nih.gov JF - Bioinformatics AU - Luna, Augustin AU - Nicodemus, Kristin K AD - GCAP/CBDB, NIMH/NIH, 10 Center Drive Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 774 EP - 776 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 6 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Linkage disequilibrium KW - Computer programs KW - software KW - Statistics KW - Haplotypes KW - Single-nucleotide polymorphism KW - Bioinformatics KW - Color KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19658088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=snp.plotter%3A+an+R-based+SNP%2Fhaplotype+association+and+linkage+disequilibrium+plotting+package&rft.au=Luna%2C+Augustin%3BNicodemus%2C+Kristin+K&rft.aulast=Luna&rft.aufirst=Augustin&rft.date=2007-03-01&rft.volume=23&rft.issue=6&rft.spage=774&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computer programs; Linkage disequilibrium; software; Statistics; Haplotypes; Single-nucleotide polymorphism; Bioinformatics; Color ER - TY - JOUR T1 - A case study of gait compensations for hip muscle weakness in idiopathic inflammatory myopathy AN - 19637334; 7378221 AB - Background The purpose of this case series was to quantify different strategies used to compensate in gait for hip muscle weakness. Methods An instrumented gait analysis was performed of three females diagnosed with idiopathic inflammatory myopathies and compared to a healthy unimpaired subject. Lower extremity joint moments obtained from the gait analysis were used to drive an induced acceleration model which determined each moments contribution to upright support, forward progression, and hip joint acceleration. Findings Results showed that after midstance, the ankle plantar flexors normally provide upright support and forward progression while producing hip extension acceleration. In normal gait, the hip flexors eccentrically resist hip extension, but the hip flexor muscles of the impaired subjects (S1-3) were too weak to control extension. Instead S1-3 altered joint positions and muscle function to produce forward progression while minimizing hip extension acceleration. S1 increased knee flexion angle to decrease the hip extension effect of the ankle plantar flexors. S2 and S3 used either a knee flexor moment or gravity to produce forward progression, which had the advantage of accelerating the hip into flexion rather than extension, and decreased the demand on the hip flexors. Interpretation Results showed how gait compensations for hip muscle weakness can produce independent (i.e. successful) ambulation, although at a reduced speed as compared to normal gait. Knowledge of these successful strategies can assist the rehabilitation of patients with hip muscle weakness who are unable to ambulate and potentially be used to reduce their disability. JF - Clinical Biomechanics AU - Siegel, Karen Lohmann AU - Kepple, Thomas M AU - Stanhope, Steven J Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 319 EP - 326 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 0268-0033, 0268-0033 KW - Physical Education Index KW - Myositis KW - Muscle weakness KW - Hip KW - Gait KW - Muscles (function) KW - Handicapped KW - Rehabilitation KW - Gravity KW - Strategy KW - Ankles KW - Knees KW - Patients KW - Health KW - Legs KW - Muscles (fatigue) KW - Acceleration KW - Hips KW - Knowledge KW - Joints KW - Speed KW - Case studies KW - Analysis KW - Biomechanics KW - PE 100:Kinesiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19637334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Biomechanics&rft.atitle=A+case+study+of+gait+compensations+for+hip+muscle+weakness+in+idiopathic+inflammatory+myopathy&rft.au=Siegel%2C+Karen+Lohmann%3BKepple%2C+Thomas+M%3BStanhope%2C+Steven+J&rft.aulast=Siegel&rft.aufirst=Karen&rft.date=2007-03-01&rft.volume=22&rft.issue=3&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=Clinical+Biomechanics&rft.issn=02680033&rft_id=info:doi/10.1016%2Fj.clinbiomech.2006.11.002 LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Handicapped; Muscles (function); Rehabilitation; Gravity; Strategy; Knees; Ankles; Legs; Health; Patients; Muscles (fatigue); Acceleration; Knowledge; Hips; Joints; Speed; Case studies; Analysis; Gait; Biomechanics DO - http://dx.doi.org/10.1016/j.clinbiomech.2006.11.002 ER - TY - JOUR T1 - Neurologic symptoms in licensed pesticide applicators in the Agricultural Health Study AN - 19611635; 7330075 AB - Exposure to high levels of many pesticides has both acute and long-term neurologic consequences, but little is known about the neurotoxicity of chronic exposure to moderate pesticide levels. We analysed cross-sectional data from 18 782 Caucasian, male, licensed pesticide applicators, enrolled in the Agricultural Health Study from 1993 to 1997. Applicators provided information on lifetime pesticide use, and 23 neurologic symptoms typically associated with pesticide intoxication. Increased risk of experiencing >10 symptoms during the year before enrollment was associated with cumulative pesticide use, personally mixing or applying pesticides, pesticide-related medical care, diagnosed pesticide poisoning, and events involving high personal pesticide exposure. Greatest risk was associated with use of organophosphate and organochlorine insecticides. Results were similar after stratification by pesticide use during the year before enrollment, or exclusion of applicators with a history of pesticide poisoning, or high-exposure events. Use of pesticide application methods likely to involve high personal exposure was associated with greater risk. Groups of symptoms reflecting several neurologic domains, including affect, cognition, autonomic and motor function, and vision, were also associated with pesticide exposure. These results suggest that neurologic symptoms are associated with cumulative exposure to moderate levels of organophosphate and organochlorine insecticides, regardless of recent exposure or history of poisoning. JF - Human & Experimental Toxicology AU - Kamel, F AU - Engel, L S AU - Gladen, B C AU - Hoppin, JA AU - Alavanja, MCR AU - Sandier, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA, kamel@mail.nih.gov Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 243 EP - 250 VL - 26 IS - 3 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Intoxication KW - Autonomic nervous system KW - Data processing KW - Organochlorine compounds KW - Poisoning KW - organophosphates KW - Cognition KW - Pesticide applications KW - Insecticides KW - Vision KW - Chronic exposure KW - Neurotoxicity KW - Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19611635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Neurologic+symptoms+in+licensed+pesticide+applicators+in+the+Agricultural+Health+Study&rft.au=Kamel%2C+F%3BEngel%2C+L+S%3BGladen%2C+B+C%3BHoppin%2C+JA%3BAlavanja%2C+MCR%3BSandier%2C+D+P&rft.aulast=Kamel&rft.aufirst=F&rft.date=2007-03-01&rft.volume=26&rft.issue=3&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327107070582 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Intoxication; Organochlorine compounds; Data processing; Autonomic nervous system; Poisoning; organophosphates; Cognition; Pesticide applications; Insecticides; Chronic exposure; Vision; Pesticides; Neurotoxicity DO - http://dx.doi.org/10.1177/0960327107070582 ER - TY - JOUR T1 - SMotif: a server for structural motifs in proteins AN - 19607478; 7314450 AB - SUMMARY: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments. AVAILABILITY: SMotif server is available via the URL http://caps.ncbs.res.in/SMotif/index.html. CONTACT: chakrabaail.nih.gov, minicbs.res.in or EPNSugantu.edu.sg Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Pugalenthi, Ganesan AU - Suganthan, P N AU - Sowdhamini, R AU - Chakrabarti, Saikat AD - School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore 639798, National Centre for Biological Sciences, Bangalore 560 065, India and National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, USA Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 637 EP - 638 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 23 IS - 5 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Protein folding KW - Protein engineering KW - Hydrogen bonding KW - Solvents KW - Conserved sequence KW - Bioinformatics KW - Packing KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607478?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SMotif%3A+a+server+for+structural+motifs+in+proteins&rft.au=Pugalenthi%2C+Ganesan%3BSuganthan%2C+P+N%3BSowdhamini%2C+R%3BChakrabarti%2C+Saikat&rft.aulast=Pugalenthi&rft.aufirst=Ganesan&rft.date=2007-03-01&rft.volume=23&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein engineering; Protein folding; Hydrogen bonding; Solvents; Conserved sequence; Packing; Bioinformatics ER - TY - JOUR T1 - Combination Therapy of an Orthotopic Renal Cell Carcinoma Model Using Intratumoral Vector-Mediated Costimulation and Systemic Interleukin-2 AN - 19603652; 7315240 AB - PURPOSE: Interleukin (IL)-2 therapy is currently used for therapy of renal cell carcinoma (RCC). However, it is only effective in approximately 10% to 15% of patients, showing a need for additional therapies. We have previously described a replication-defective fowlpox vector encoding three costimulatory molecules (B7-1, ICAM-1, and LFA-3), designated rF-TRICOM. Here, we show that intratumoral administration of rF-TRICOM in an orthotopic RCC model effectively enhances tumor immunogenicity and reduces tumor burden in mice and the combination of rF-TRICOM and IL-2 is more effective than either therapy alone. Experimental Design: RCC cells were implanted under the capsule of the kidney, and mice were given rF-TRICOM intratumorally 14 days later. We compared the effect of rF-TRICOM, rF-granulocyte macrophage colony-stimulating factor (GM-CSF), and two doses of IL-2 and combinations of the above on antitumor efficacy and survival. Host CD4 super(+) and CD8 super(+) T-cell responses were also evaluated. RESULTS: The results show that (a) systemic IL-2 therapy was moderately effective in the reduction of tumor burden in an orthotopic RCC model; (b) a single intratumoral injection of rF-TRICOM and rF-GM-CSF significantly reduced tumor burden; (c) the addition of systemic IL-2 to intratumoral rF-TRICOM/rF-GM-CSF administration resulted in further reduction of tumor burden, decrease in the incidence of metastasis, and extended survival in tumor-bearing mice above that seen with either treatment alone; and (d) CD8 super(+) T cells played a critical role in the antitumor effect seen with rF-TRICOM/rF-GM-CSF + IL-2 therapy. Finally, the addition of systemic recombinant IL-15 or intratumoral vector-delivered IL-15 to intratumoral rF-TRICOM/rF-GM-CSF administration resulted in substantially more tumor-free mice than either therapy alone. CONCLUSIONS: These studies show that intratumoral administration of rF-TRICOM admixed with rF-GM-CSF is effective at reducing tumor burden in mice and the addition of IL-2 further contributes to this effect. These studies thus form the rationale for combination immunotherapy clinical trials in patients with RCC. JF - Clinical Cancer Research AU - Kudo-Saito, Chie AU - Wansley, Elizabeth K AU - Gruys, MEilene AU - Wiltrout, Robert AU - Schlom, Jeffrey AU - Hodge, James W AD - Authors' Affiliations: Laboratories of Tumor Immunology and Biology and Experimental Immunology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 1936 EP - 1946 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 13 IS - 6 SN - 1078-0432, 1078-0432 KW - Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Interleukin 2 KW - Fowlpox KW - Immunotherapy KW - Animal models KW - Cell culture KW - Macrophage colony-stimulating factor KW - Clinical trials KW - Metastases KW - CD4 antigen KW - renal cell carcinoma KW - Interleukin 15 KW - intercellular adhesion molecule 1 KW - Lymphocytes T KW - CD58 antigen KW - Granulocyte-macrophage colony-stimulating factor KW - Vectors KW - CD8 antigen KW - Tumors KW - B7-1 antigen KW - Costimulator KW - Immunogenicity KW - Kidney KW - Antitumor activity KW - W 30905:Medical Applications KW - V 22350:Immunology KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=Combination+Therapy+of+an+Orthotopic+Renal+Cell+Carcinoma+Model+Using+Intratumoral+Vector-Mediated+Costimulation+and+Systemic+Interleukin-2&rft.au=Kudo-Saito%2C+Chie%3BWansley%2C+Elizabeth+K%3BGruys%2C+MEilene%3BWiltrout%2C+Robert%3BSchlom%2C+Jeffrey%3BHodge%2C+James+W&rft.aulast=Kudo-Saito&rft.aufirst=Chie&rft.date=2007-03-01&rft.volume=13&rft.issue=6&rft.spage=1936&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Fowlpox; Interleukin 2; Immunotherapy; Granulocyte-macrophage colony-stimulating factor; Animal models; CD58 antigen; Vectors; Cell culture; Macrophage colony-stimulating factor; Tumors; CD8 antigen; Clinical trials; Metastases; Costimulator; B7-1 antigen; CD4 antigen; Interleukin 15; renal cell carcinoma; Immunogenicity; intercellular adhesion molecule 1; Kidney; Lymphocytes T; Antitumor activity ER - TY - JOUR T1 - The effect of haem in red and processed meat on the endogenous formation of N-nitroso compounds in the upper gastrointestinal tract AN - 19603280; 7314939 AB - Red and processed meat (PM) consumption increases the risk of large bowel cancer and it has been demonstrated that haem in red meat (RM) stimulates the endogenous production of N-nitroso compounds (NOCs) within the human intestine. To investigate whether N-nitrosation occurs in the upper gastrointestinal tract, 27 ileostomists were fed diets containing no meat, or 240 g RM or 240 g PM in a randomly assigned crossover intervention design carried out in a volunteer suite. Endogenous NOC were assessed as apparent total N-nitroso compounds (ATNC) in the ileostomy output. ATNC concentration in the diets was 22 mu g ATNC/kg (RM) and 37 mu g ATNC/kg (PM), and 9 mu g ATNC/kg in the no meat diet. Levels significantly increased to 1175 mu g ATNC/kg SEM = 226 mu g ATNC/kg) following the RM (P = 0.001) and 1832 mu g ATNC/kg (SEM = 294 mu g ATNC/kg) following PM (P < 0.001) compared to the no meat diet (283 mu g ATNC/kg, SEM = 74 mu g ATNC/kg). ATNC concentrations in the ileal output were equivalent to those measured in faeces in similarly designed feeding studies. Supplementation with either 1 g ascorbic acid or 400 IU alpha -tocopherol had no effect on the concentration of ATNC detected in the ileal output. In in vitro experiments, N-nitrosomorpholine (NMor) was formed in the presence of nitrosated haemoglobin, at pH 6.8 but not in the absence of nitrosated haemoglobin. These findings demonstrate that haem may facilitate the formation of NOC in the absence of colonic flora in the upper human gastrointestinal tract. JF - Carcinogenesis AU - Lunn, J C AU - Kuhnle, G AU - Mai, V AU - Frankenfeld, C AU - Shuker, DEG AU - Glen, R C AU - Goodman, J M AU - Pollock, JRA AU - Bingham, SA AD - MRC Dunn Human Nutrition Unit, MRC/Wellcome Trust Building Cambridge, CB2 2XY, UK. Department of Epidemiology and Preventive Medicine, University of Maryland Medical School Baltimore, MD 21201, USA. Division of Cancer Epidemiology and Genetics, National Cancer Institute Bethesda, MD, USA. The Unilever Centre for Molecular Sciences Informatics, University of Cambridge Cambridge, UK. Department of Chemistry, The Open University Milton Keynes, UK. Pollock and Pool Ltd, Woodley Reading, Berkshire, RG5 4DX, UK Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 685 EP - 690 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 3 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - Cancer KW - Supplementation KW - Ascorbic acid KW - Hemoglobin KW - Meat KW - Vitamin E KW - N-Nitroso compounds KW - N-Nitrosomorpholine KW - Digestive tract KW - Carcinogenesis KW - Intestine KW - Ileostomy KW - Feces KW - pH effects KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19603280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+haem+in+red+and+processed+meat+on+the+endogenous+formation+of+N-nitroso+compounds+in+the+upper+gastrointestinal+tract&rft.au=Lunn%2C+J+C%3BKuhnle%2C+G%3BMai%2C+V%3BFrankenfeld%2C+C%3BShuker%2C+DEG%3BGlen%2C+R+C%3BGoodman%2C+J+M%3BPollock%2C+JRA%3BBingham%2C+SA&rft.aulast=Lunn&rft.aufirst=J&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Diets; Supplementation; Cancer; Ascorbic acid; Meat; Hemoglobin; N-Nitroso compounds; Vitamin E; Digestive tract; N-Nitrosomorpholine; Carcinogenesis; Intestine; Ileostomy; Feces; pH effects ER - TY - JOUR T1 - A Target Cell-Specific Activatable Fluorescence Probe for In vivo Molecular Imaging of Cancer Based on a Self-Quenched Avidin-Rhodamine Conjugate AN - 19597762; 7314901 AB - A target cell-specific activation strategy for improved molecular imaging of peritoneal implants has been proposed, in which fluorophores are activated only in living targeted cells. A current example of an activatable fluorophore is one that is normally self-quenched by attachment to a peptide backbone but which can be activated by specific proteases that degrade the peptide resulting in "dequenching." In this study, an alternate fluorescence activation strategy is proposed whereby self-quenching avidin-rhodamine X, which has affinity for lectin on cancer cells, is activated after endocytosis and degradation within the lysosome. Using this approach in a mouse model of peritoneal ovarian metastases, we document target-specific molecular imaging of submillimeter cancer nodules with minimal contamination by background signal. Cellular internalization of receptor-ligand pairs with subsequent activation of fluorescence via dequenching provides a generalizable and highly sensitive method of detecting cancer microfoci in vivo and has practical implications for assisting surgical and endoscopic procedures. [Cancer Res 2007; 67(6):2791-9] JF - Cancer Research AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Kamiya, Mako AU - Bernardo, Marcelino AU - Paik, Ronald S AU - Shin, In Soo AU - Paik, Chang H AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 2791 EP - 2799 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 67 IS - 6 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Fluorescence KW - Contamination KW - Peritoneum KW - Animal models KW - Lectins KW - fluorophores KW - imaging KW - Nodules KW - Cancer KW - Metastases KW - Endocytosis KW - Fluorescent indicators KW - Proteinase KW - Lysosomes KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19597762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=A+Target+Cell-Specific+Activatable+Fluorescence+Probe+for+In+vivo+Molecular+Imaging+of+Cancer+Based+on+a+Self-Quenched+Avidin-Rhodamine+Conjugate&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BKamiya%2C+Mako%3BBernardo%2C+Marcelino%3BPaik%2C+Ronald+S%3BShin%2C+In+Soo%3BPaik%2C+Chang+H%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-03-01&rft.volume=67&rft.issue=6&rft.spage=2791&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Fluorescence; Contamination; Peritoneum; Animal models; Lectins; fluorophores; imaging; Cancer; Nodules; Metastases; Endocytosis; Fluorescent indicators; Proteinase; Lysosomes ER - TY - JOUR T1 - New Tuberculosis Drugs in Development AN - 19487987; 8516156 AB - Over the past 50 years, no new drug classes have been introduced to treat tuberculosis. Tuberculosis (TB) kills nearly two million people a year mainly in the poorest communities in the developing world. It afflicts millions more. About one third of the world's population is silently infected with TB that may erupt into disease with increased age or suppression of the immune system. Nearly nine million new active cases develop every year. The World Health Organization (WHO) declared the disease a global emergency as long ago as 1993. Although huge efforts in public health control have reduced the disease burden within most established market economies, in Africa and Asia the epidemic continues to accelerate, particularly fueled by the HIV epidemic. Furthermore, resistance to the standard drugs isoniazid and rifampicin is increasing worldwide. Since the 1990s, mycobacteria have emerged with resistance patterns rendering all currently available antibiotics ineffectual. The pharmaceutical industry has mostly abandoned TB drug development due to perceived non-profitable consumer market and the diminishing number of companies engaged in anti-infective research. The public sector and infectious disease researchers have responded to advance fundamental science and to create new chemical entities as early drug candidates. With support from research funding agencies, philanthropic donors, and the STOP-TB Partnership, new chemical tools and new approaches to effectively implement TB control programs are evolving. Advanced preclinical development and strategies for Phase III clinical trials remain gap areas that will require additional engagement from all sectors. JF - Current Topics in Medicinal Chemistry AU - Laughon, Barbara E AD - Division of AIDS, NIAID,National Institutes of Health, 6700-B Rockledge Drive Room 5108,Bethesda, MD 20892-7624, USA. Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 463 EP - 473 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 7 IS - 6 SN - 1568-0266, 1568-0266 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Tuberculosis KW - mycobacterium KW - drug development KW - medicinal chemistry KW - public-private partnerships KW - antibiotics KW - multidrug resistance KW - latency KW - acquired immunodeficiency syndrome: complications KW - antitubercular agents KW - Age KW - Epidemics KW - Mycobacterium KW - Immune system KW - Control programs KW - Antibiotics KW - Drug development KW - Development KW - Clinical trials KW - Public health KW - Rifampin KW - Infectious diseases KW - Human immunodeficiency virus KW - Reviews KW - Pharmaceuticals KW - Consumers KW - Drugs KW - Isoniazid KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19487987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Topics+in+Medicinal+Chemistry&rft.atitle=New+Tuberculosis+Drugs+in+Development&rft.au=Laughon%2C+Barbara+E&rft.aulast=Laughon&rft.aufirst=Barbara&rft.date=2007-03-01&rft.volume=7&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802607780059736 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Age; Epidemics; Control programs; Immune system; Drug development; Antibiotics; Development; Clinical trials; Public health; Rifampin; Infectious diseases; Reviews; Pharmaceuticals; Tuberculosis; Consumers; Drugs; Isoniazid; Mycobacterium; Human immunodeficiency virus DO - http://dx.doi.org/10.2174/156802607780059736 ER - TY - JOUR T1 - Lessons Learned From the Children's Environmental Exposure Research Study AN - 19443592; 7285728 AB - We examined 5 different ethical concerns about the Children's Environmental Exposure Research Study and make some recommendations for future studies of exposure to hazardous environmental agents in the home. Researchers should seek community consultation and participation; make participants aware of all the risks associated with the research, including hazards discovered in the home and uncertainties about the risks of agents under investigation; and take steps to ensure that their studies will not have unfair representation of the poor or people of color. Researchers should also avoid even the appearance of a financial conflict of interest in studies that are likely to be controversial and make it clear to all parties that studies will not intentionally expose subjects to hazardous environmental agents. JF - American Journal of Public Health AU - Resnik, David B AU - Wing, Steven AD - David B. Resnik is with the National Institute of Environmental Sciences (NIEHS), National Institutes of Health (NIH), Research Triangle Park, NC. Steven Wing is with the School of Public Health at the University of North Carolina, Chapel Hill Y1 - 2007/03// PY - 2007 DA - Mar 2007 SP - 414 EP - 418 PB - American Public Health Association, 1015 15th St., N.W. Washington DC 20005 USA VL - 97 IS - 3 SN - 0090-0036, 0090-0036 KW - Pollution Abstracts; Sustainability Science Abstracts; Health & Safety Science Abstracts KW - Hazardous materials KW - Ethics KW - Residential areas KW - Environmental health KW - Pollution effects KW - Children KW - Research programs KW - Public health KW - conflict of interests KW - M3 1010:Issues in Sustainable Development KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19443592?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Public+Health&rft.atitle=Lessons+Learned+From+the+Children%27s+Environmental+Exposure+Research+Study&rft.au=Resnik%2C+David+B%3BWing%2C+Steven&rft.aulast=Resnik&rft.aufirst=David&rft.date=2007-03-01&rft.volume=97&rft.issue=3&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Public+Health&rft.issn=00900036&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hazardous materials; Ethics; Residential areas; Pollution effects; Environmental health; Children; Research programs; conflict of interests; Public health ER - TY - CPAPER T1 - Patterns of Antihypertensive Therapy in the Jackson Heart Study Cohort T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40547076; 4530132 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Walker, Evelyn R AU - Wyatt, Sharon B AU - Wofford, Marion AU - Nelson, Cheryl AU - Akylbekova, Ermekgul AU - Wilson, Gregory AU - Keahy, Wanda AU - Taylor, Herman A AU - Jones, Dan Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Antihypertensives KW - Heart KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40547076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=SMotif%3A+a+server+for+structural+motifs+in+proteins&rft.au=Pugalenthi%2C+Ganesan%3BSuganthan%2C+P+N%3BSowdhamini%2C+R%3BChakrabarti%2C+Saikat&rft.aulast=Pugalenthi&rft.aufirst=Ganesan&rft.date=2007-03-01&rft.volume=23&rft.issue=5&rft.spage=637&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-wide Association with Adiposity-related Traits: The Framingham Heart Study 100K Project T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40546892; 4530060 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Fox, Caroline S AU - Heard-Costa, Nancy AU - Cupples, L Adrienne AU - Dupuis, Josee AU - Vasan, Ramachandran S AU - Atwood, Larry D Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Genome-wide+Association+with+Adiposity-related+Traits%3A+The+Framingham+Heart+Study+100K+Project&rft.au=Fox%2C+Caroline+S%3BHeard-Costa%2C+Nancy%3BCupples%2C+L+Adrienne%3BDupuis%2C+Josee%3BVasan%2C+Ramachandran+S%3BAtwood%2C+Larry+D&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Subcutaneous and Visceral Adipose Tissue and their Association with Coronary and Aortic Artery Calcification: The Framingham Heart Study T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40546054; 4530059 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Fox, Caroline S AU - Hwang, Shih-Jen AU - Massaro, Joseph M AU - Pou, Karla M AU - Larson, Martin G AU - Hoffmann, Udo AU - O'Donnell, Christopher J Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Adipose tissues KW - Adipose tissue KW - Calcification (ectopic) KW - Arteries KW - Heart KW - Aorta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40546054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Subcutaneous+and+Visceral+Adipose+Tissue+and+their+Association+with+Coronary+and+Aortic+Artery+Calcification%3A+The+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BMassaro%2C+Joseph+M%3BPou%2C+Karla+M%3BLarson%2C+Martin+G%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validated Parental History of Premature Cardiovascular Disease as a Risk Factor for Coronary Artery Calcification in the Framingham Third-generation Cohort T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40545074; 4530356 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - Parikh, Nisha I AU - Hwang, Shih-Jen AU - Larson, Martin G AU - Fox, Caroline S AU - Manders, Emily S AU - Murabito, Joanne AU - Massaro, Joseph M AU - Hoffmann, Udo AU - O'Donnell, Christopher J Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Historical account KW - Cardiovascular diseases KW - Calcification (ectopic) KW - Coronary artery KW - Risk factors KW - Circulatory system KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40545074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Validated+Parental+History+of+Premature+Cardiovascular+Disease+as+a+Risk+Factor+for+Coronary+Artery+Calcification+in+the+Framingham+Third-generation+Cohort&rft.au=Parikh%2C+Nisha+I%3BHwang%2C+Shih-Jen%3BLarson%2C+Martin+G%3BFox%2C+Caroline+S%3BManders%2C+Emily+S%3BMurabito%2C+Joanne%3BMassaro%2C+Joseph+M%3BHoffmann%2C+Udo%3BO%27Donnell%2C+Christopher+J&rft.aulast=Parikh&rft.aufirst=Nisha&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering Genetic Determinants for Subclinical Atherosclerosis in Multiple Arterial Beds: Genome-Wide Association Study in the NHLBI Framingham Heart Study T2 - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AN - 40543726; 4530314 JF - 47th Annual Conference on Cardiovascular Disease Epidemiology and Prevention in Association with the Council on Nutrition, Physical Activity, and Metabolism AU - O'Donnell, Christopher J AU - Demissie, Serkalem AU - Murabito, Joanne M AU - Fox, Caroline S AU - Hwang, Shih-Jen AU - Wang, Thomas J AU - Cupples, L Adrienne Y1 - 2007/02/28/ PY - 2007 DA - 2007 Feb 28 KW - Arteriosclerosis KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40543726?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.atitle=Deciphering+Genetic+Determinants+for+Subclinical+Atherosclerosis+in+Multiple+Arterial+Beds%3A+Genome-Wide+Association+Study+in+the+NHLBI+Framingham+Heart+Study&rft.au=O%27Donnell%2C+Christopher+J%3BDemissie%2C+Serkalem%3BMurabito%2C+Joanne+M%3BFox%2C+Caroline+S%3BHwang%2C+Shih-Jen%3BWang%2C+Thomas+J%3BCupples%2C+L+Adrienne&rft.aulast=O%27Donnell&rft.aufirst=Christopher&rft.date=2007-02-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=47th+Annual+Conference+on+Cardiovascular+Disease+Epidemiology+and+Prevention+in+Association+with+the+Council+on+Nutrition%2C+Physical+Activity%2C+and+Metabolism&rft.issn=&rft_id=info:doi/ L2 - http://www.americanheart.org/presenter.jhtml?identifier=3038389 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. AN - 70280794; 17360629 AB - Brefeldin A-inhibited guanine nucleotide-exchange proteins (GEPs) BIG1 and BIG2 activate ADP-ribosylation factor (ARF) GTPases, which are required for vesicular trafficking. Both molecules contain one or more sites for binding protein kinase A, i.e., A kinase-anchoring protein (AKAP) sequences. Elevation of cell cAMP caused PKA-catalyzed phosphorylation and nuclear accumulation of BIG1 but not BIG2. We then asked whether BIG1 phosphorylation altered its GEP activity. Incubation of BIG1 or BIG2 with PKA catalytic subunits and ATP resulted in retardation of their electrophoretic migration, consistent with PKA phosphorylation. Okadaic acid inhibits many protein phosphatases, including protein phosphatase 1 (PP1) and PP2A, that can reverse PKA-catalyzed phosphorylation. Incubation of HepG2 cells with okadaic acid caused concentration-dependent accumulation of presumably phosphorylated BIG1 and BIG2 with decreased mobility, which was increased by subsequent incubation in vitro with specific recombinant phosphatases, PP1gamma > PP2A >> PP1alpha. For assays of GEP activity, BIG1 and BIG2 were immunoprecipitated from cells that had been depleted, respectively, of BIG2 and BIG1 by using specific siRNA. GEP activity of each was significantly decreased after incubation with recombinant PKA plus ATP and restored by incubation with PP1gamma. In agreement with a role for PP1gamma in regulation of BIG, endogenous PP1gamma, but not PP1alpha or beta, was immunoprecipitated with BIG1 or BIG2 from microsomal fractions. All observations are consistent with the effects of BIG1 and BIG2 phosphorylation on vesicular trafficking, via alterations in ARF activation and regulatory roles for cAMP, PKA, and PP1gamma in ARF activation by BIG1 and BIG2. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Kuroda, Fuminobu AU - Moss, Joel AU - Vaughan, Martha AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1434, USA. Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 3201 EP - 3206 VL - 104 IS - 9 SN - 0027-8424, 0027-8424 KW - ARFGEF1 protein, human KW - 0 KW - Guanine Nucleotide Exchange Factors KW - Vesicular Transport Proteins KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Cyclic AMP-Dependent Protein Kinases KW - EC 2.7.11.11 KW - Phosphoprotein Phosphatases KW - EC 3.1.3.16 KW - Protein Phosphatase 1 KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - Index Medicus KW - Microscopy, Fluorescence KW - Blotting, Western KW - Phosphorylation KW - Humans KW - Adenosine Triphosphate -- metabolism KW - Immunoprecipitation KW - Okadaic Acid -- metabolism KW - Cell Line, Tumor KW - Cyclic AMP-Dependent Protein Kinases -- metabolism KW - ADP-Ribosylation Factors -- metabolism KW - Guanine Nucleotide Exchange Factors -- metabolism KW - Phosphoprotein Phosphatases -- metabolism KW - Vesicular Transport Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70280794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Regulation+of+brefeldin+A-inhibited+guanine+nucleotide-exchange+protein+1+%28BIG1%29+and+BIG2+activity+via+PKA+and+protein+phosphatase+1gamma.&rft.au=Kuroda%2C+Fuminobu%3BMoss%2C+Joel%3BVaughan%2C+Martha&rft.aulast=Kuroda&rft.aufirst=Fuminobu&rft.date=2007-02-27&rft.volume=104&rft.issue=9&rft.spage=3201&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Trends Cell Biol. 2000 Feb;10(2):60-7 [10652516] Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2683-8 [16467138] J Clin Invest. 2000 Sep;106(5):R31-8 [10974026] J Cell Sci. 2002 Jan 15;115(Pt 2):241-56 [11839776] Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1627-32 [12571360] J Biol Chem. 2003 May 23;278(21):18817-23 [12657641] Physiol Rev. 2004 Jan;84(1):1-39 [14715909] Mol Biol Cell. 2004 Apr;15(4):1487-505 [14742722] EMBO J. 2004 Jul 21;23(14):2811-20 [15229649] Curr Biol. 2004 Aug 24;14(16):1436-50 [15324660] Annu Rev Biochem. 1989;58:453-508 [2549856] Annu Rev Biochem. 1990;59:971-1005 [2165385] Crit Rev Oncol Hematol. 1995 Nov;21(1-3):33-61 [8822496] Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12856-60 [8917509] Nature. 1996 Dec 5;384(6608):481-4 [8945478] J Biol Chem. 1997 Feb 14;272(7):3993-8 [9020105] EMBO J. 1997 Apr 15;16(8):1876-87 [9155014] Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2635-40 [16477018] Trends Biochem Sci. 2006 Jun;31(6):316-23 [16690317] J Cell Sci. 2006 Sep 15;119(Pt 18):3764-75 [16926194] Mol Cell. 2006 Nov 3;24(3):383-95 [17081989] J Biol Chem. 1997 May 16;272(20):12881-4 [9190362] Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4204-8 [9539714] J Biol Chem. 1998 Aug 21;273(34):21431-4 [9705267] J Biol Chem. 1998 Dec 25;273(52):35048-55 [9857038] J Biol Chem. 1999 Apr 30;274(18):12308-15 [10212200] J Biol Chem. 1999 Oct 8;274(41):29057-62 [10506157] Cell Cycle. 2005 Feb;4(2):323-9 [15655353] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2567-72 [10716990] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Requirements for DNA hairpin formation by RAG1/2. AN - 70272558; 17307873 AB - The rearrangement of antigen receptor genes is initiated by double-strand breaks catalyzed by the RAG1/2 complex at the junctions of recombination signal sequences and coding segments. As with some "cut-and-paste" transposases, such as Tn5 and Hermes, a DNA hairpin is formed at one end of the break via a nicked intermediate. By using abasic DNA substrates, we show that different base positions are important for the two steps of cleavage. Removal of one base in the coding flank enhances hairpin formation, bypassing a requirement for a paired complex of two signal sequences. Rescue by abasic substrates is consistent with a base-flip mechanism seen in the crystal structure of the Tn5 postcleavage complex and may mimic the DNA changes on paired complex formation. We have searched for a tryptophan residue in RAG1 that would be the functional equivalent of W298 in Tn5, which stabilizes the DNA interaction by stacking the flipped base on the indole ring. A W956A mutation in RAG1 had an inhibitory effect on both nicking and hairpin stages that could be rescued by abasic substrates. W956 is therefore a likely candidate for interacting with this base during hairpin formation. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Grundy, Gabrielle J AU - Hesse, Joanne E AU - Gellert, Martin AD - Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 5, Room 241, Bethesda, MD 20892, USA. Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 3078 EP - 3083 VL - 104 IS - 9 SN - 0027-8424, 0027-8424 KW - DNA-Binding Proteins KW - 0 KW - Homeodomain Proteins KW - Nuclear Proteins KW - RAG2 protein, human KW - RAG-1 protein KW - 128559-51-3 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Electrophoretic Mobility Shift Assay KW - Mutation -- genetics KW - DNA Breaks, Single-Stranded KW - Mutagenesis KW - Nuclear Proteins -- genetics KW - Homeodomain Proteins -- genetics KW - DNA -- metabolism KW - Homeodomain Proteins -- metabolism KW - DNA-Binding Proteins -- genetics KW - Nuclear Proteins -- metabolism KW - Nucleic Acid Conformation KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Requirements+for+DNA+hairpin+formation+by+RAG1%2F2.&rft.au=Grundy%2C+Gabrielle+J%3BHesse%2C+Joanne+E%3BGellert%2C+Martin&rft.aulast=Grundy&rft.aufirst=Gabrielle&rft.date=2007-02-27&rft.volume=104&rft.issue=9&rft.spage=3078&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-03-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2001 Mar;21(6):2038-47 [11238939] Nature. 1998 Aug 20;394(6695):744-51 [9723614] EMBO J. 2001 Jun 1;20(11):2931-42 [11387226] Genetics. 2001 Jul;158(3):949-57 [11454746] Mol Cell Biol. 2002 Jan;22(1):69-77 [11739723] J Biol Chem. 2002 Mar 29;277(13):11284-91 [11805107] Mol Cell Biol. 2002 May;22(10):3460-73 [11971977] Annu Rev Biochem. 2002;71:101-32 [12045092] Mol Cell Biol. 1999 Dec;19(12):8094-102 [10567535] Cell. 1998 Aug 21;94(4):463-70 [9727489] Annu Rev Biochem. 1998;67:181-98 [9759487] Cell. 1998 Oct 2;95(1):125-34 [9778253] Mol Cell Biol. 1999 May;19(5):3788-97 [10207102] Nature. 2004 Dec 23;432(7020):995-1001 [15616554] Nat Struct Mol Biol. 2005 Aug;12(8):715-21 [16041385] Mol Cell. 2005 Oct 7;20(1):143-54 [16209952] Nat Immunol. 2005 Dec;6(12):1272-9 [16286921] Nat Struct Mol Biol. 2006 Nov;13(11):1010-5 [17028591] Genes Dev. 1999 Dec 1;13(23):3059-69 [10601032] Genes Dev. 1999 Dec 1;13(23):3070-80 [10601033] Mol Cell. 2000 Jan;5(1):97-107 [10678172] Science. 2000 Jul 7;289(5476):77-85 [10884228] Cell. 2000 Jun 9;101(6):625-33 [10892649] Mol Cell Biol. 2001 Jan;21(2):459-66 [11134334] EMBO J. 2002 Aug 1;21(15):4162-71 [12145216] Mol Cell Biol. 2002 Oct;22(20):7217-25 [12242298] Mol Cell Biol. 2002 Nov;22(22):7790-801 [12391148] EMBO J. 2003 Apr 15;22(8):1931-8 [12682025] Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13768-73 [15365172] Nature. 1983 Apr 14;302(5909):575-81 [6300689] Genes Dev. 1993 Jul;7(7B):1459-69 [8330743] Nucleic Acids Res. 1993 Dec 11;21(24):5644-50 [8284210] Genes Dev. 1995 Sep 1;9(17):2193-9 [7657170] Cell. 1995 Nov 3;83(3):387-95 [8521468] Nature. 1996 Mar 7;380(6569):85-8 [8598914] Cell. 1996 Apr 5;85(1):107-13 [8620529] EMBO J. 1996 Jun 17;15(12):3197-206 [8670820] Mol Cell Biol. 1996 Oct;16(10):5683-90 [8816481] J Exp Med. 1997 Jun 2;185(11):2025-32 [9166431] EMBO J. 1997 May 15;16(10):2665-70 [9184213] Genetics. 1998 Jun;149(2):693-701 [9611184] Mol Cell Biol. 1998 Aug;18(8):4679-88 [9671478] Immunity. 1998 Jul;9(1):115-25 [9697841] Nat Struct Biol. 2001 Apr;8(4):302-7 [11276247] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Control of the Secretomes of Bacillus Cereus Group Members by the PlcR/PapR System T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40623827; 4566565 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Pomerantsev, A P AU - Pomerantseva, O M AU - Leppla, S H AU - Baillie, L W Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Secretome KW - Phospholipase C KW - Bacillus cereus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40623827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.atitle=Human+stem+cells%2C+chromatin%2C+and+tissue+engineering%3A+Boosting+relevancy+in+developmental+toxicity+testing&rft.au=Cho%2C+Elizabeth%3BLi%2C+Wan-Ju&rft.aulast=Cho&rft.aufirst=Elizabeth&rft.date=2007-03-01&rft.volume=81&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+C%3A+Embryo+Today%3A+Reviews&rft.issn=1542975X&rft_id=info:doi/10.1002%2Fbdrc.20087 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Virus Microarray T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622923; 4566586 DE: JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Baptista, C S AU - Wu, X. AU - Shannon, E AU - Stewart, C AU - Nordstrom, H AU - Lundkvist, A AU - Munroe, D J Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Virus+Microarray&rft.au=Baptista%2C+C+S%3BWu%2C+X.%3BShannon%2C+E%3BStewart%2C+C%3BNordstrom%2C+H%3BLundkvist%2C+A%3BMunroe%2C+D+J&rft.aulast=Baptista&rft.aufirst=C&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Candidate Q Fever Diagnostic Antigens Revealed by Immunoscreening a Coxiella burnetii Protein Microarray T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622749; 4566545 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Beare, P A AU - Cockrell, D C AU - Barbian, K D AU - Porcella, S F AU - Pablo, J AU - Chen, C AU - Samuel, J E AU - Felgner, P L AU - Heinzen, R A Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Protein arrays KW - Q fever KW - Antigens KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=Candidate+Q+Fever+Diagnostic+Antigens+Revealed+by+Immunoscreening+a+Coxiella+burnetii+Protein+Microarray&rft.au=Beare%2C+P+A%3BCockrell%2C+D+C%3BBarbian%2C+K+D%3BPorcella%2C+S+F%3BPablo%2C+J%3BChen%2C+C%3BSamuel%2C+J+E%3BFelgner%2C+P+L%3BHeinzen%2C+R+A&rft.aulast=Beare&rft.aufirst=P&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blood Pressure Increases with Norepinephrine Infusion Improved Survival with Lipopolysaccharide (LPS) but not Anthrax Lethal Toxin (LeTx) Challenge in Rats T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40622601; 4566593 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Li, Y. AU - Cui, X AU - Su, J. AU - Sherer, K AU - Leppla, S AU - Moayeri, M AU - Kenyon, N AU - Scher, D AU - Fitz, Y AU - Eichacker, P Q Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Anthrax lethal toxin KW - Survival KW - Rats KW - Lipopolysaccharides KW - Blood pressure KW - Norepinephrine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40622601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Benefits+of+the+combination+of+thalidomide+plus+cyclophosphamide+in+hormone+refractory+prostate+cancer+patients.&rft.au=Al-Chalabi%2C+Tania%3BFigg%2C+William+D&rft.aulast=Al-Chalabi&rft.aufirst=Tania&rft.date=2007-03-01&rft.volume=6&rft.issue=3&rft.spage=318&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selection of Anthrax Toxin Protective Antigen Variants that Discriminate between the Cellular Receptors TEM8 and CMG2 and Achieve Targeting of Tumor Cells T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40620881; 4566552 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Chen, K AU - Lu, S. AU - Bankston, L A AU - Liddington, R C AU - Leppla, S H Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Anthrax KW - Toxins KW - Tumor cells KW - Protective antigen KW - Tumors KW - Antigens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40620881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Environmental+and+behavioral+factors+and+the+risk+of+non-Hodgkin+lymphoma.&rft.au=Hartge%2C+Patricia%3BSmith%2C+Martyn+T&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2007-03-01&rft.volume=16&rft.issue=3&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Method to Study Pathogenesis of Tick-Borne Flavivirus Infection in Tick Larvae. T2 - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AN - 40620848; 4566549 JF - 5th Annual Meeting of the American Society for Microbiology Biodefense and Emerging Diseases Research AU - Mitzel, D N AU - Wolfinbarger, J M AU - Best, S M AU - Bloom, M E Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 KW - Infection KW - Larvae KW - Flavivirus KW - Ixodidae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40620848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.atitle=A+Novel+Method+to+Study+Pathogenesis+of+Tick-Borne+Flavivirus+Infection+in+Tick+Larvae.&rft.au=Mitzel%2C+D+N%3BWolfinbarger%2C+J+M%3BBest%2C+S+M%3BBloom%2C+M+E&rft.aulast=Mitzel&rft.aufirst=D&rft.date=2007-02-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+American+Society+for+Microbiology+Biodefense+and+Emerging+Diseases+Research&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFE7DAF5E%2DA0D2%2D4977% 2D8C64%2D57DACAE944D7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Investigating the "Steric Gate" of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase by Targeted Insertion of Unnatural Amino Acids AN - 19794224; 7730242 AB - To investigate how structural changes in the amino acid side chain affect nucleotide substrate selection in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), a variety of non-natural tyrosine analogues were substituted for Tyr115 of p66 RT. RT variants containing meta-Tyr, nor-Tyr, aminomethyl-Phe, and 1- and 2-naphthyl-Tyr were produced in an Escherichia coli coupled transcription/translation system. Mutant p66 subunits were reconstituted with wild-type (WT) p51 RT and purified by affinity chromatography. Each modified enzyme retained DNA polymerase activity following mis procedure. Aminomethyl-Phe115 RT incorporated dCTP more efficiently than the WT and was resistant to the chain terminator (-)- beta -2',3'-dideoxy-3'-thiacytidine triphosphate (3TCTP) when examined in a steady-state fidelity assay. However, 2-naphthyl-Tyr115 RT inefficiently incorporated dCTP at low concentrations and was kinetically slower with all dCTP analogues tested. Models of RT containing these side chains suggest that the aminomethyl-Phe115 substitution provides new hydrogen bonds through the minor groove to the incoming dNTP and the template residue of the terminal base pair. These hydrogen bonds likely contribute to the increased efficiency of dCTP incorporation. In contrast, models of HIV-1 RT containing 2-naphthyl-Tyr115 reveal significant steric clashes with Pro157 of the p66 palm subdomain, necessitating rearrangement of the active site. JF - Biochemistry (Washington) AU - Klarmann, G J AU - Eisenhauer, B M AU - Zhang, Y AU - Gotte, M AU - Pata, J D AU - Chatterjee, D K AU - Hecht, S M AU - Le Grice, SFJ AD - HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA Y1 - 2007/02/27/ PY - 2007 DA - 2007 Feb 27 SP - 2118 EP - 2126 VL - 46 IS - 8 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Translation KW - Amino acids KW - Tyrosine KW - Enzymes KW - Transcription KW - Nucleotides KW - Models KW - Affinity chromatography KW - Fidelity KW - Insertion KW - Hydrogen bonding KW - DNA-directed DNA polymerase KW - Human immunodeficiency virus 1 KW - Escherichia coli KW - RNA-directed DNA polymerase KW - Base pairs KW - Amino acid sequence KW - J 02310:Genetics & Taxonomy KW - V 22360:AIDS and HIV KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19794224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Investigating+the+%22Steric+Gate%22+of+Human+Immunodeficiency+Virus+Type+1+%28HIV-1%29+Reverse+Transcriptase+by+Targeted+Insertion+of+Unnatural+Amino+Acids&rft.au=Klarmann%2C+G+J%3BEisenhauer%2C+B+M%3BZhang%2C+Y%3BGotte%2C+M%3BPata%2C+J+D%3BChatterjee%2C+D+K%3BHecht%2C+S+M%3BLe+Grice%2C+SFJ&rft.aulast=Klarmann&rft.aufirst=G&rft.date=2007-02-27&rft.volume=46&rft.issue=8&rft.spage=2118&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi061772w LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Amino acids; Transcription; Enzymes; Tyrosine; Nucleotides; Models; Affinity chromatography; Fidelity; Hydrogen bonding; Insertion; DNA-directed DNA polymerase; RNA-directed DNA polymerase; Amino acid sequence; Base pairs; Human immunodeficiency virus 1; Escherichia coli DO - http://dx.doi.org/10.1021/bi061772w ER - TY - CPAPER T1 - An Evaluation of the Influence of a Weir Built Cross the Tongkong River to Take Subsurface Flow on the Groundwater Quality and Aquaculture Animal Health T2 - 2007 Aquaculture: Science for Sustainable Aquaculture (AQUACULTURE 2007) AN - 40657484; 4576343 JF - 2007 Aquaculture: Science for Sustainable Aquaculture (AQUACULTURE 2007) AU - Sun, Peter Lin Y1 - 2007/02/26/ PY - 2007 DA - 2007 Feb 26 KW - Aquifers KW - Ground water KW - Rivers KW - Weirs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40657484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Aquaculture%3A+Science+for+Sustainable+Aquaculture+%28AQUACULTURE+2007%29&rft.atitle=An+Evaluation+of+the+Influence+of+a+Weir+Built+Cross+the+Tongkong+River+to+Take+Subsurface+Flow+on+the+Groundwater+Quality+and+Aquaculture+Animal+Health&rft.au=Sun%2C+Peter+Lin&rft.aulast=Sun&rft.aufirst=Peter&rft.date=2007-02-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Aquaculture%3A+Science+for+Sustainable+Aquaculture+%28AQUACULTURE+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.was.org/meetings/SessionsByDay.asp?MeetingCode=AQ2007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Circuitry of Addiction in Humans T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40522446; 4517149 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Volkow, Nora D Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Addiction KW - Neural networks KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522446?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+Improvement&rft.atitle=Developing+Preservice+Teachers%3A+A+Self-Study+of+Instructor+Scaffolding&rft.au=Kindle%2C+Karen+J.%3BSchmidt%2C+Cynthia+M.&rft.aulast=Kindle&rft.aufirst=Karen&rft.date=2013-01-01&rft.volume=50&rft.issue=3&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Reading+Improvement&rft.issn=00340510&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetics of Human Addictions T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40521840; 4517151 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Goldman, David Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Genetics KW - Addiction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Educational+Research&rft.atitle=The+Most+Important+Thing%3A+Students+with+Reading+and+Writing+Difficulties+Talk+about+Their+Experiences+of+Teachers%27+Treatment+and+Guidance&rft.au=Nielsen%2C+Cecilia&rft.aulast=Nielsen&rft.aufirst=Cecilia&rft.date=2011-01-01&rft.volume=55&rft.issue=5&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Educational+Research&rft.issn=00313831&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relapse to Food Seeking: Recent Findings T2 - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AN - 40519285; 4517111 JF - 2007 Keystone Symposia on Neurobiology of Addiction (C3) AU - Shaham, Yavin Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Food KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40519285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Neurobiology+of+Addiction+%28C3%29&rft.atitle=Relapse+to+Food+Seeking%3A+Recent+Findings&rft.au=Shaham%2C+Yavin&rft.aulast=Shaham&rft.aufirst=Yavin&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Neurobiology+of+Addiction+%28C3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cbl-Dependent Internalization of TCR-Induced, LAT-Nucleated Signaling Complexes T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518892; 4517022 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Barr, Valarie A Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Signal transduction KW - T-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Cbl-Dependent+Internalization+of+TCR-Induced%2C+LAT-Nucleated+Signaling+Complexes&rft.au=Barr%2C+Valarie+A&rft.aulast=Barr&rft.aufirst=Valarie&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Directed Cell-Cell Interactions in the Development of Adaptive Immunity T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518679; 4516991 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Germain, Ronald N Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Cell interactions KW - Immunity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518679?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Directed+Cell-Cell+Interactions+in+the+Development+of+Adaptive+Immunity&rft.au=Germain%2C+Ronald+N&rft.aulast=Germain&rft.aufirst=Ronald&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the B-Cell Receptor Signaling in the Immunological Synapse T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518520; 4517020 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Tolar, Pavel Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Signal transduction KW - Immunological synapses KW - Imaging techniques KW - B-cell receptor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518520?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Imaging+the+B-Cell+Receptor+Signaling+in+the+Immunological+Synapse&rft.au=Tolar%2C+Pavel&rft.aulast=Tolar&rft.aufirst=Pavel&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of B Cell Motility in Lymph Nodes T2 - 2007 Keystone Symposia on Imaging Immune Responses (J7) AN - 40518443; 4517002 JF - 2007 Keystone Symposia on Imaging Immune Responses (J7) AU - Kehrl, John H Y1 - 2007/02/25/ PY - 2007 DA - 2007 Feb 25 KW - Lymphocytes B KW - Lymph nodes KW - Cell migration KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40518443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.atitle=Regulation+of+B+Cell+Motility+in+Lymph+Nodes&rft.au=Kehrl%2C+John+H&rft.aulast=Kehrl&rft.aufirst=John&rft.date=2007-02-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Imaging+Immune+Responses+%28J7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 0&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes. AN - 70357465; 17408499 AB - Commonly employed clustering methods for analysis of gene expression data do not directly incorporate phenotypic data about the samples. Furthermore, clustering of samples with known phenotypes is typically performed in an informal fashion. The inability of clustering algorithms to incorporate biological data in the grouping process can limit proper interpretation of the data and its underlying biology. We present a more formal approach, the modk-prototypes algorithm, for clustering biological samples based on simultaneously considering microarray gene expression data and classes of known phenotypic variables such as clinical chemistry evaluations and histopathologic observations. The strategy involves constructing an objective function with the sum of the squared Euclidean distances for numeric microarray and clinical chemistry data and simple matching for histopathology categorical values in order to measure dissimilarity of the samples. Separate weighting terms are used for microarray, clinical chemistry and histopathology measurements to control the influence of each data domain on the clustering of the samples. The dynamic validity index for numeric data was modified with a category utility measure for determining the number of clusters in the data sets. A cluster's prototype, formed from the mean of the values for numeric features and the mode of the categorical values of all the samples in the group, is representative of the phenotype of the cluster members. The approach is shown to work well with a simulated mixed data set and two real data examples containing numeric and categorical data types. One from a heart disease study and another from acetaminophen (an analgesic) exposure in rat liver that causes centrilobular necrosis. The modk-prototypes algorithm partitioned the simulated data into clusters with samples in their respective class group and the heart disease samples into two groups (sick and buff denoting samples having pain type representative of angina and non-angina respectively) with an accuracy of 79%. This is on par with, or better than, the assignment accuracy of the heart disease samples by several well-known and successful clustering algorithms. Following modk-prototypes clustering of the acetaminophen-exposed samples, informative genes from the cluster prototypes were identified that are descriptive of, and phenotypically anchored to, levels of necrosis of the centrilobular region of the rat liver. The biological processes cell growth and/or maintenance, amine metabolism, and stress response were shown to discern between no and moderate levels of acetaminophen-induced centrilobular necrosis. The use of well-known and traditional measurements directly in the clustering provides some guarantee that the resulting clusters will be meaningfully interpretable. JF - BMC systems biology AU - Bushel, Pierre R AU - Wolfinger, Russell D AU - Gibson, Greg AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. bushel@niehs.nih.gov Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 15 VL - 1 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Rats KW - Phenotype KW - Animals KW - Necrosis KW - Liver -- pathology KW - Liver -- drug effects KW - Humans KW - Heart Diseases -- genetics KW - Heart Diseases -- blood KW - Disease Models, Animal KW - Heart Diseases -- pathology KW - Acetaminophen -- toxicity KW - Gene Expression Profiling -- statistics & numerical data KW - Clinical Chemistry Tests -- statistics & numerical data KW - Algorithms KW - Data Interpretation, Statistical KW - Cluster Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70357465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+systems+biology&rft.atitle=Simultaneous+clustering+of+gene+expression+data+with+clinical+chemistry+and+pathological+evaluations+reveals+phenotypic+prototypes.&rft.au=Bushel%2C+Pierre+R%3BWolfinger%2C+Russell+D%3BGibson%2C+Greg&rft.aulast=Bushel&rft.aufirst=Pierre&rft.date=2007-02-23&rft.volume=1&rft.issue=&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=BMC+systems+biology&rft.issn=1752-0509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-26 N1 - Date created - 2007-04-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2003 May;111(6):A338-9 [12760838] BMC Bioinformatics. 2007;8:38 [17270052] Mutat Res. 2003 Nov;544(2-3):349-60 [14644337] Cancer Res. 2004 Mar 1;64(5):1584-8 [14996713] Toxicol Sci. 2004 Jun;79(2):411-22 [15056800] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] J Virol. 2004 Oct;78(19):10420-32 [15367608] J Pharmacol Exp Ther. 1973 Oct;187(1):195-202 [4746327] Toxicology. 1988 Dec 30;53(2-3):323-9 [3212790] Mol Carcinog. 1999 Mar;24(3):153-9 [10204799] Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):6745-50 [10359783] Science. 1999 Oct 15;286(5439):531-7 [10521349] Bioinformatics. 2004 Nov 22;20(17):3137-45 [15217814] Nat Rev Genet. 2004 Dec;5(12):936-48 [15573125] Environ Health Perspect. 2004 Nov;112(16):1589-606 [15598610] Bioinformatics. 2005 Feb 15;21(4):423-9 [15608052] Toxicol Pathol. 2005;33(1):111-7 [15805062] Bioinformatics. 2006 Jan 1;22(1):77-87 [16249259] Bioinformatics. 2006 Jul 15;22(14):e184-90 [16873470] Nat Genet. 2000 May;25(1):25-9 [10802651] Cell. 2000 Jul 7;102(1):109-26 [10929718] J Hepatol. 2000 Sep;33(3):395-406 [11019995] N Engl J Med. 2001 Feb 22;344(8):539-48 [11207349] Bioinformatics. 2001 Apr;17(4):309-18 [11301299] Genome Res. 2001 Aug;11(8):1425-33 [11483584] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] Toxicol Sci. 2002 Jun;67(2):219-31 [12011481] Toxicol Sci. 2002 Jun;67(2):232-40 [12011482] Genet Epidemiol. 2002 Jun;23(1):87-96 [12112250] Curr Opin Mol Ther. 2002 Jun;4(3):229-35 [12139308] Toxicol Pathol. 2002 Jul-Aug;30(4):470-82 [12187938] EHP Toxicogenomics. 2003 Jan;111(1T):53-60 [12735110] Environ Health Perspect. 2003 Aug;111(11):A581-9 [12928155] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - EWORS Utilization as a Complementary Surveillance Tool for Detecting Dengue Outbreaks T2 - 2007 International Meeting on Emerging Diseases and Surveillance (IMED 2007) AN - 40627564; 4567579 JF - 2007 International Meeting on Emerging Diseases and Surveillance (IMED 2007) AU - Siswoyo, H AU - Laras, K AU - Suwandono, A AU - Tresnaningsih, E AU - Adimidjaja, T AU - Simanjuntak, C AU - Larasati, R AU - Glass, J Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Outbreaks KW - Dengue KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40627564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Meeting+on+Emerging+Diseases+and+Surveillance+%28IMED+2007%29&rft.atitle=EWORS+Utilization+as+a+Complementary+Surveillance+Tool+for+Detecting+Dengue+Outbreaks&rft.au=Siswoyo%2C+H%3BLaras%2C+K%3BSuwandono%2C+A%3BTresnaningsih%2C+E%3BAdimidjaja%2C+T%3BSimanjuntak%2C+C%3BLarasati%2C+R%3BGlass%2C+J&rft.aulast=Siswoyo&rft.aufirst=H&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Meeting+on+Emerging+Diseases+and+Surveillance+%28IMED+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://imed.isid.org/Downloads/IMED2007_AbstrAuth.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Cytokine Heterogeneity within the Th2 Subset T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40535430; 4521337 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Kim, N AU - Foster, B A AU - Prussin, C Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Cytokines KW - Lymphocytes T KW - Helper cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Identification+of+Cytokine+Heterogeneity+within+the+Th2+Subset&rft.au=Kim%2C+N%3BFoster%2C+B+A%3BPrussin%2C+C&rft.aulast=Kim&rft.aufirst=N&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cockroach Allergen Reduction by Extermination Alone in Low-Income, Urban Homes-A Randomized Control Trial T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40529268; 4522062 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Sever, M L AU - Arbes Jr., S.J. AU - Zeldin, D C AU - Schal, C AU - Santangelo, R G AU - Gore, J C AU - Vaughn, B AU - Mitchell, H Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Socio-economic aspects KW - Allergens KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reading+%26+Writing+Quarterly&rft.atitle=Teaching+Reading+Fluency+to+Struggling+Readers%3A+Method%2C+Materials%2C+and+Evidence&rft.au=Rasinski%2C+Timothy%3BHoman%2C+Susan%3BBiggs%2C+Marie&rft.aulast=Rasinski&rft.aufirst=Timothy&rft.date=2009-04-01&rft.volume=25&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Reading+%26+Writing+Quarterly&rft.issn=10573569&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TGF-beta Stimulated Human CD4+CD25-FOXP3- Cells Express FOXP3, but Lack Regulatory Function T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40527830; 4522218 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Tran, D AU - Shevach, E M Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Foxp3 protein KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527830?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=TGF-beta+Stimulated+Human+CD4%2BCD25-FOXP3-+Cells+Express+FOXP3%2C+but+Lack+Regulatory+Function&rft.au=Tran%2C+D%3BShevach%2C+E+M&rft.aulast=Tran&rft.aufirst=D&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ascaris Antigens Suppress Experimental Allergic Inflammation T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40526359; 4521490 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Trivedi, S AU - Hodges, M G AU - Bundoc, V AU - Norris, H H AU - Boesen, A AU - Madala, S AU - Urban, J F AU - Keane-Myers, A Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Hypersensitivity KW - Inflammation KW - Antigens KW - Ascaris KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Ascaris+Antigens+Suppress+Experimental+Allergic+Inflammation&rft.au=Trivedi%2C+S%3BHodges%2C+M+G%3BBundoc%2C+V%3BNorris%2C+H+H%3BBoesen%2C+A%3BMadala%2C+S%3BUrban%2C+J+F%3BKeane-Myers%2C+A&rft.aulast=Trivedi&rft.aufirst=S&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parental Smoking Modifies Effects of Genetic Variation in Tumor Necrosis Factor-a on Childhood Asthma T2 - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AN - 40521860; 4521557 JF - 2007 Annual Meeting of the American Academy of Allergy Asthma and Immunology (AAAAI 2007) AU - Wu, H. AU - Romieu, I AU - Sienra-Monge, J AU - Rio-Navarro, B AU - Anderson, D M AU - Dunn, E W AU - Steiner, L L AU - Lara-Sanchez, I AU - London, S Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 KW - Respiratory diseases KW - Asthma KW - Smoking KW - Genetic diversity KW - Tumor necrosis factor-a KW - Children KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.atitle=Parental+Smoking+Modifies+Effects+of+Genetic+Variation+in+Tumor+Necrosis+Factor-a+on+Childhood+Asthma&rft.au=Wu%2C+H.%3BRomieu%2C+I%3BSienra-Monge%2C+J%3BRio-Navarro%2C+B%3BAnderson%2C+D+M%3BDunn%2C+E+W%3BSteiner%2C+L+L%3BLara-Sanchez%2C+I%3BLondon%2C+S&rft.aulast=Wu&rft.aufirst=H.&rft.date=2007-02-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Annual+Meeting+of+the+American+Academy+of+Allergy+Asthma+and+Immunology+%28AAAAI+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BADB9F23F%2D599E%2D4E3C% 2D8BFE%2D532DF96F148F%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study AN - 20745439; 7436524 AB - Background Seafood is the predominant source of omega-3 fatty adds, which are essential for optimum neural development However, in the USA, women are advised to limit their seafood intake during pregnancy to 340 g per week. We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy. Methods 11875 pregnant women completed a food frequency questionnaire assessing seafood consumption at 32 weeks' gestation. Multivariable logistic regression models including 28 potential confounders assessing social disadvantage, perinatal, and dietary items were used to compare developmental, behavioural, and cognitive outcomes of the children from age 6 months to 8 years in women consuming none, some (1-340 g per week), and >340 g per week. Findings After adjustment, maternal seafood intake during pregnancy of less than 340 g per week was associated with increased risk of their children being in the lowest quartile for verbal intelligence quotient (IQ) (no seafood consumption, odds ratio [OR] 1.48, 95% CI 1.16-1.90; some, 1.09, 0.92-1.29; overall trend, p=0.004), compared with mothers who consumed more than 340 g per week. Low maternal seafood intake was also associated with increased risk of suboptimum outcomes for prosocial behaviour, fine motor, communication, and social development scores. For each outcome measure, the lower the intake of seafood during pregnancy, the higher the risk of suboptimum developmental outcome. Interpretation Maternalseafood consumption of less than 340 g per week in pregnancy did not protect children from adverse outcomes; rather, we recorded beneficial effects on child development with maternal seafood intakes of more than 340 g per week, suggesting that advice to limit seafood consumption could actually be detrimental. These results show that risks from the loss of nutrients were greater than the risks of harm from exposure to trace contaminants in 340 g seafood eaten weekly. JF - Lancet AU - Hibbeln, J R AU - Davis, J M AU - Steer, C AU - Emmett, P AU - Rogers, I AU - Williams, C AU - Golding, J AD - Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA, jhibbeln@mail.nih.gov Y1 - 2007/02/23/ PY - 2007 DA - 2007 Feb 23 SP - 578 EP - 585 VL - 369 IS - 9561 SN - 0099-5355, 0099-5355 KW - CSA Neurosciences Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - Longitudinal studies KW - Food KW - Communication KW - Nutrients KW - Risk factors KW - Gestation KW - Regression analysis KW - Seafood KW - intelligence KW - Diets KW - Inventories KW - Children KW - Pregnancy KW - nutrients KW - Intelligence KW - USA KW - Cognitive ability KW - Neurotoxicity KW - Contaminants KW - longitudinal studies KW - N3 11028:Neuropharmacology & toxicology KW - X 24320:Food Additives & Contaminants KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20745439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+effect+of+haem+in+red+and+processed+meat+on+the+endogenous+formation+of+N-nitroso+compounds+in+the+upper+gastrointestinal+tract&rft.au=Lunn%2C+J+C%3BKuhnle%2C+G%3BMai%2C+V%3BFrankenfeld%2C+C%3BShuker%2C+DEG%3BGlen%2C+R+C%3BGoodman%2C+J+M%3BPollock%2C+JRA%3BBingham%2C+SA&rft.aulast=Lunn&rft.aufirst=J&rft.date=2007-03-01&rft.volume=28&rft.issue=3&rft.spage=685&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inventories; Food; Communication; Nutrients; Children; Pregnancy; Intelligence; Cognitive ability; Risk factors; Gestation; Regression analysis; Seafood; Contaminants; Longitudinal studies; Diets; nutrients; Neurotoxicity; longitudinal studies; intelligence; USA ER - TY - CPAPER T1 - State-Level Youth Access Legislation and Indoor Smoking Restrictions Among School-Aged Children T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40656743; 4579286 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Botello-Harbaum, Maria T AU - Iannotti, Ronald J AU - Haynie, Denise AU - Gase, Lauren AU - Simons-Morton, Bruce Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Smoking KW - Children KW - Legislation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40656743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=State-Level+Youth+Access+Legislation+and+Indoor+Smoking+Restrictions+Among+School-Aged+Children&rft.au=Botello-Harbaum%2C+Maria+T%3BIannotti%2C+Ronald+J%3BHaynie%2C+Denise%3BGase%2C+Lauren%3BSimons-Morton%2C+Bruce&rft.aulast=Botello-Harbaum&rft.aufirst=Maria&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Consumer Awareness and Attitudes Related to New Potential Reduce-Exposure Tobacco Product Brands T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40655419; 4578961 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Parascandola, Mark AU - Augustson, Erik AU - Hurd, Ami AU - Marcus, Stephen Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Attitudes KW - Tobacco KW - Consumers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40655419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Consumer+Awareness+and+Attitudes+Related+to+New+Potential+Reduce-Exposure+Tobacco+Product+Brands&rft.au=Parascandola%2C+Mark%3BAugustson%2C+Erik%3BHurd%2C+Ami%3BMarcus%2C+Stephen&rft.aulast=Parascandola&rft.aufirst=Mark&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pilot Study Testing Feasibility and Efficacy of Nicotine Replacement Therapy in Pregnant African American Smokers T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40654120; 4579222 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - El-Mohandes, Ayman Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - Africa KW - Nicotine KW - Ethnic groups KW - Feasibility studies KW - Pregnancy KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40654120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=A+Pilot+Study+Testing+Feasibility+and+Efficacy+of+Nicotine+Replacement+Therapy+in+Pregnant+African+American+Smokers&rft.au=El-Mohandes%2C+Ayman&rft.aulast=El-Mohandes&rft.aufirst=Ayman&rft.date=2007-02-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Other Tobacco Products Among U.S. Adult Cigarette Smokers T2 - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AN - 40652973; 4579175 JF - 13th Annual Meeting of the Society for Research on Nicotine and Tobacco AU - Backinger, Cathy L AU - Fagan, Pebbles AU - OConnell, Mary E AU - Grana, Rachel Y1 - 2007/02/21/ PY - 2007 DA - 2007 Feb 21 KW - USA KW - Tobacco KW - Cigarettes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40652973?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=US-China+Education+Review&rft.atitle=Special+Needs+Students+in+Higher+Education&rft.au=Jones%2C+Lise+Oen%3BKrumsvik%2C+Rune&rft.aulast=Jones&rft.aufirst=Lise&rft.date=2008-03-01&rft.volume=5&rft.issue=3&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=US-China+Education+Review&rft.issn=15486613&rft_id=info:doi/ L2 - http://www.srnt.org/meeting/2007/pdf/onsite/2007SRNTAbstracts-FINAL.pd f LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Physiologic Functions of Lipids as Revealed by Knockout Mice T2 - 2007 Keystone Symposia on Bioactive Lipids in the Lipidomics Era (C2) AN - 40538199; 4516823 JF - 2007 Keystone Symposia on Bioactive Lipids in the Lipidomics Era (C2) AU - Proia, Richard L Y1 - 2007/02/20/ PY - 2007 DA - 2007 Feb 20 KW - Lipids KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538199?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Bioactive+Lipids+in+the+Lipidomics+Era+%28C2%29&rft.atitle=Physiologic+Functions+of+Lipids+as+Revealed+by+Knockout+Mice&rft.au=Proia%2C+Richard+L&rft.aulast=Proia&rft.aufirst=Richard&rft.date=2007-02-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Bioactive+Lipids+in+the+Lipidomics+Era+%28C2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Level Sets on Non-Planar Manifolds for Ridge Detection on Isosurfaces T2 - 2007 SPIE Conference on Medical Imaging AN - 40538607; 4523505 JF - 2007 SPIE Conference on Medical Imaging AU - Tan, S AU - Yao, J AU - Ward, M M AU - Yao, L AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Ridges KW - Manifolds KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Level+Sets+on+Non-Planar+Manifolds+for+Ridge+Detection+on+Isosurfaces&rft.au=Tan%2C+S%3BYao%2C+J%3BWard%2C+M+M%3BYao%2C+L%3BSummers%2C+R+M&rft.aulast=Tan&rft.aufirst=S&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parsimonious Model Selection for Tissue Classification: A DTI Study of Zebrafish T2 - 2007 SPIE Conference on Medical Imaging AN - 40537656; 4523498 JF - 2007 SPIE Conference on Medical Imaging AU - Freidlin, R Z AU - Loew, M H AU - Basser, P J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Classification KW - Models KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40537656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Parsimonious+Model+Selection+for+Tissue+Classification%3A+A+DTI+Study+of+Zebrafish&rft.au=Freidlin%2C+R+Z%3BLoew%2C+M+H%3BBasser%2C+P+J&rft.aulast=Freidlin&rft.aufirst=R&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of Two CAD Systems for Breast Cancer using Dynamic Contrast Enhanced MRI T2 - 2007 SPIE Conference on Medical Imaging AN - 40537176; 4523730 JF - 2007 SPIE Conference on Medical Imaging AU - Chattrabhuti, K AU - Yao, J AU - Hill, S AU - Chow, C Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Breast cancer KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40537176?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Music+Educators+Journal&rft.atitle=Children+with+Disabilities+Playing+Musical+Instruments%3A+With+the+Right+Adaptations+and+Help+from+Their+Teachers+and+Parents%2C+Students+with+Disabilities+Can+Play+Musical+Instruments&rft.au=McCord%2C+Kimberly%3BFitzgerald%2C+Margaret&rft.aulast=McCord&rft.aufirst=Kimberly&rft.date=2006-03-01&rft.volume=92&rft.issue=4&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Music+Educators+Journal&rft.issn=00274321&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Improved Livewire Method for Segmentation on Low-Contrast and Noisy Images T2 - 2007 SPIE Conference on Medical Imaging AN - 40535867; 4523504 JF - 2007 SPIE Conference on Medical Imaging AU - Chen, D AU - Yao, J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Segmentation KW - Image processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535867?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Improved+Livewire+Method+for+Segmentation+on+Low-Contrast+and+Noisy+Images&rft.au=Chen%2C+D%3BYao%2C+J&rft.aulast=Chen&rft.aufirst=D&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Collaborative Classifiers in CT Colonography CAD T2 - 2007 SPIE Conference on Medical Imaging AN - 40535848; 4523751 DE: JF - 2007 SPIE Conference on Medical Imaging AU - Yao, J AU - Li, J. AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Collaborative+Classifiers+in+CT+Colonography+CAD&rft.au=Yao%2C+J%3BLi%2C+J.%3BSummers%2C+R+M&rft.aulast=Yao&rft.aufirst=J&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Performance Analysis of Cervix Roi Extraction and Specular Reflection Removal Algorithms for Uterine Cervix Image Indexing T2 - 2007 SPIE Conference on Medical Imaging AN - 40534449; 4523561 JF - 2007 SPIE Conference on Medical Imaging AU - Xue, Z AU - Antani, S K AU - Long, L R AU - Jeronimo, J AU - Thoma, G R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Indexing KW - Cervix KW - Algorithms KW - Uterus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Comparative+Performance+Analysis+of+Cervix+Roi+Extraction+and+Specular+Reflection+Removal+Algorithms+for+Uterine+Cervix+Image+Indexing&rft.au=Xue%2C+Z%3BAntani%2C+S+K%3BLong%2C+L+R%3BJeronimo%2C+J%3BThoma%2C+G+R&rft.aulast=Xue&rft.aufirst=Z&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Semi-Automatic Tissue Classification of Magnetic Resonance Images of the Thigh for Application to Large-Scale Datasets T2 - 2007 SPIE Conference on Medical Imaging AN - 40533748; 4523528 JF - 2007 SPIE Conference on Medical Imaging AU - Monzon, A AU - Hemler, P F AU - Nalls, M A AU - Manini, T M AU - Clark, B C AU - Harris, T AU - McAuliffe, M J Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Magnetic resonance imaging KW - Classification KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533748?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Semi-Automatic+Tissue+Classification+of+Magnetic+Resonance+Images+of+the+Thigh+for+Application+to+Large-Scale+Datasets&rft.au=Monzon%2C+A%3BHemler%2C+P+F%3BNalls%2C+M+A%3BManini%2C+T+M%3BClark%2C+B+C%3BHarris%2C+T%3BMcAuliffe%2C+M+J&rft.aulast=Monzon&rft.aufirst=A&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Validating Pareto Optimal Operation Parameters of Polyp Detection Algorithms for CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40531228; 4523750 JF - 2007 SPIE Conference on Medical Imaging AU - Li, J. AU - Huang, A AU - Petrick, N A AU - Yao, J AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=A+comprehensive+investigation+of+2-amino-1-methyl-6-phenylimidazo%5B4%2C5-b%5Dpyridine+%28PhIP%29+metabolism+in+the+mouse+using+a+multivariate+data+analysis+approach.&rft.au=Chen%2C+Chi%3BMa%2C+Xiaochao%3BMalfatti%2C+Michael+A%3BKrausz%2C+Kristopher+W%3BKimura%2C+Shioko%3BFelton%2C+James+S%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Chen&rft.aufirst=Chi&rft.date=2007-03-01&rft.volume=20&rft.issue=3&rft.spage=531&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gaps in Content-Based Image Retrieval T2 - 2007 SPIE Conference on Medical Imaging AN - 40529721; 4523346 JF - 2007 SPIE Conference on Medical Imaging AU - Lehmann, T M AU - Antani, S K AU - Long, L R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Data processing KW - Databases KW - Mining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemistry+%26+biology&rft.atitle=Chemical+genetic+screening+identifies+critical+pathways+in+anthrax+lethal+toxin-induced+pathogenesis.&rft.au=Panchal%2C+Rekha+G%3BRuthel%2C+Gordon%3BBrittingham%2C+Katherine+C%3BLane%2C+Douglas%3BKenny%2C+Tara+A%3BGussio%2C+Rick%3BLazo%2C+John+S%3BBavari%2C+Sina&rft.aulast=Panchal&rft.aufirst=Rekha&rft.date=2007-03-01&rft.volume=14&rft.issue=3&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Chemistry+%26+biology&rft.issn=10745521&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - (ST) Intra-Patient Colon Surface Registration Based on Taeniae coli T2 - 2007 SPIE Conference on Medical Imaging AN - 40529577; 4523246 JF - 2007 SPIE Conference on Medical Imaging AU - Lamy, J AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Colon KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529577?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=%28ST%29+Intra-Patient+Colon+Surface+Registration+Based+on+Taeniae+coli&rft.au=Lamy%2C+J%3BSummers%2C+R+M&rft.aulast=Lamy&rft.aufirst=J&rft.date=2007-02-17&rft.volume=42&rft.issue=3&rft.spage=164&rft.isbn=&rft.btitle=&rft.title=Reading+Improvement&rft.issn=00340510&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Colonic Wall Thickness using Level Sets for CT Virtual Colonoscopy Visual Assessment and Polyp Detection T2 - 2007 SPIE Conference on Medical Imaging AN - 40529569; 4523101 JF - 2007 SPIE Conference on Medical Imaging AU - Van Uitert, R. AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529569?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Colonic+Wall+Thickness+using+Level+Sets+for+CT+Virtual+Colonoscopy+Visual+Assessment+and+Polyp+Detection&rft.au=Van+Uitert%2C+R.%3BSummers%2C+R+M&rft.aulast=Van+Uitert&rft.aufirst=R.&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Optimal Parameters and Pitfalls for Kernel Method of Surface Curvature Estimation for CT Colonography Computer-Aided Polyp Detection T2 - 2007 SPIE Conference on Medical Imaging AN - 40527353; 4523455 JF - 2007 SPIE Conference on Medical Imaging AU - Campbell, S AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Kernels KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Optimal+Parameters+and+Pitfalls+for+Kernel+Method+of+Surface+Curvature+Estimation+for+CT+Colonography+Computer-Aided+Polyp+Detection&rft.au=Campbell%2C+S%3BSummers%2C+R+M&rft.aulast=Campbell&rft.aufirst=S&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Pareto Fronts to Evaluate Polyp Detection Algorithms for CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40527188; 4523241 JF - 2007 SPIE Conference on Medical Imaging AU - Huang, A AU - Li, J. AU - Summers, R M AU - Petrick, N A AU - Hara, A K Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Polyps KW - Algorithms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40527188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Using+Pareto+Fronts+to+Evaluate+Polyp+Detection+Algorithms+for+CT+Colonography&rft.au=Huang%2C+A%3BLi%2C+J.%3BSummers%2C+R+M%3BPetrick%2C+N+A%3BHara%2C+A+K&rft.aulast=Huang&rft.aufirst=A&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using the Teniae Coli as a Registration Tool in CT Colonography T2 - 2007 SPIE Conference on Medical Imaging AN - 40525950; 4523103 JF - 2007 SPIE Conference on Medical Imaging AU - Jabour, P A AU - Huang, A AU - Summers, R M Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Endoscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40525950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Using+the+Teniae+Coli+as+a+Registration+Tool+in+CT+Colonography&rft.au=Jabour%2C+P+A%3BHuang%2C+A%3BSummers%2C+R+M&rft.aulast=Jabour&rft.aufirst=P&rft.date=2007-02-17&rft.volume=1&rft.issue=1&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Politics+%26+Gender&rft.issn=1743923X&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring Access to Scientific Literature using Content-Based Image Retrieval T2 - 2007 SPIE Conference on Medical Imaging AN - 40525549; 4523348 JF - 2007 SPIE Conference on Medical Imaging AU - Lehmann, T M AU - Antani, S K AU - Long, L R Y1 - 2007/02/17/ PY - 2007 DA - 2007 Feb 17 KW - Data processing KW - Databases KW - Mining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40525549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+SPIE+Conference+on+Medical+Imaging&rft.atitle=Exploring+Access+to+Scientific+Literature+using+Content-Based+Image+Retrieval&rft.au=Lehmann%2C+T+M%3BAntani%2C+S+K%3BLong%2C+L+R&rft.aulast=Lehmann&rft.aufirst=T&rft.date=2007-02-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+SPIE+Conference+on+Medical+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://spie.org/conferences/programs/07/mi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Ca2+/calmodulin kinase II-dependent phosphorylation of ryanodine receptors suppresses Ca2+ sparks and Ca2+ waves in cardiac myocytes. AN - 69018890; 17234969 AB - The multifunctional Ca(2+)/calmodulin-dependent protein kinase II delta(C) (CaMKIIdelta(C)) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca(2+) release channels in the heart. However, the functional role of CaMKII-dependent phosphorylation of RyR2 is highly controversial. To address this issue, we expressed wild-type, constitutively active, or dominant-negative CaMKIIdelta(C) via adenoviral gene transfer in cultured adult rat ventricular myocytes. CaMKII-mediated phosphorylation of RyR2 was reduced, enhanced, or unaltered by dominant-negative, constitutively active, or wild-type CaMKIIdelta(C) expression, whereas phosphorylation of phospholamban at Thr17, an endogenous indicator of CaMKII activity, was at 73%, 161%, or 115% of the control group expressing beta-galactosidase (beta-gal), respectively. In parallel with the phospholamban phosphorylation, the decay kinetics of global Ca(2+) transients was slowed, accelerated, or unchanged, whereas spontaneous Ca(2+) spark activity was hyperactive, depressed, or unchanged in dominant-negative, constitutively active, or wild-type CaMKIIdelta(C) groups, respectively. When challenged by high extracellular Ca(2+), both wild-type and constitutively active CaMKIIdelta(C) protected the cells from store overload-induced Ca(2+) release, manifested by a approximately 60% suppression of Ca(2+) waves (at 2 to 20 mmol/L extracellular Ca(2+)) in spite of an elevated sarcoplasmic reticulum Ca(2+) content, whereas dominant-negative CaMKIIdelta(C) promoted Ca(2+) wave production (at 20 mmol/L Ca(2+)) with significantly depleted sarcoplasmic reticulum Ca(2+). Taken together, our data support the notion that CaMKIIdelta(C) negatively regulates RyR2 activity and spontaneous sarcoplasmic reticulum Ca(2+) release, thereby affording a negative feedback that stabilizes local and global Ca(2+)-induced Ca(2+) release in the heart. JF - Circulation research AU - Yang, Dongmei AU - Zhu, Wei-Zhong AU - Xiao, Bailong AU - Brochet, Didier X P AU - Chen, S R Wayne AU - Lakatta, Edward G AU - Xiao, Rui-Ping AU - Cheng, Heping AD - Laboratory of Cardiovascular Science, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Y1 - 2007/02/16/ PY - 2007 DA - 2007 Feb 16 SP - 399 EP - 407 VL - 100 IS - 3 KW - Calmodulin KW - 0 KW - Isoenzymes KW - Recombinant Fusion Proteins KW - Ryanodine Receptor Calcium Release Channel KW - Prkcd protein, rat KW - EC 2.7.1.- KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Calmodulin -- metabolism KW - Animals KW - Action Potentials KW - Recombinant Fusion Proteins -- physiology KW - Calcium -- metabolism KW - Models, Cardiovascular KW - Mutagenesis, Site-Directed KW - Rats KW - Rats, Sprague-Dawley KW - Cells, Cultured -- metabolism KW - Genes, Dominant KW - Isoenzymes -- physiology KW - Phosphorylation KW - Sarcoplasmic Reticulum -- metabolism KW - Adaptation, Physiological KW - Protein Processing, Post-Translational -- physiology KW - Calcium Signaling -- physiology KW - Myocardial Contraction -- physiology KW - Protein Kinase C-delta -- physiology KW - Ryanodine Receptor Calcium Release Channel -- metabolism KW - Protein Kinase C-delta -- genetics KW - Myocytes, Cardiac -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69018890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Circulation+research&rft.atitle=Ca2%2B%2Fcalmodulin+kinase+II-dependent+phosphorylation+of+ryanodine+receptors+suppresses+Ca2%2B+sparks+and+Ca2%2B+waves+in+cardiac+myocytes.&rft.au=Yang%2C+Dongmei%3BZhu%2C+Wei-Zhong%3BXiao%2C+Bailong%3BBrochet%2C+Didier+X+P%3BChen%2C+S+R+Wayne%3BLakatta%2C+Edward+G%3BXiao%2C+Rui-Ping%3BCheng%2C+Heping&rft.aulast=Yang&rft.aufirst=Dongmei&rft.date=2007-02-16&rft.volume=100&rft.issue=3&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Circulation+research&rft.issn=1524-4571&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Circ Res. 2007 Feb 16;100(3):293-5 [17307966] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Osmotic stress-dependent repression is mediated by histone H3 phosphorylation and chromatin structure. AN - 69001146; 17158874 AB - Histone H3 phosphorylation has been linked to various environmental stress responses and specific chromatin structure. The role of H3 phosphorylation in the osmotic stress response was investigated on the mouse mammary tumor virus (MMTV) promoter in different chromatin configurations. Hormone-dependent transcription from the MMTV promoter is repressed by osmotic stress when the promoter is integrated and has a normal chromatin structure. However, when the MMTV promoter is transiently transfected, the chromatin structure is less organized, and hormone induction is not affected by osmotic stress. On the integrated MMTV promoter, phosphorylation of histone H3 serine 10 and 28 increases in response to osmotic stress, but the transient promoter shows no change. Hormone-dependent glucocorticoid receptor binding is reduced on the repressed promoter, and elevated H3 phosphorylation is temporally correlated with maximal MMTV repression Additionally, the protein kinase C inhibitor rottlerin, but not other kinase inhibitors, blocks both histone H3 phosphorylation and osmotic repression of MMTV transcription. Glucocorticoid receptor binding is inversely correlated with H3 phosphorylation, suggesting that displacement of the glucocorticoid receptor from the promoter is due to H3 phosphorylation and is the mechanism for the osmotic repression of hormone-dependent transcription. JF - The Journal of biological chemistry AU - Burkhart, Barbara A AU - Kennett, Sarah B AU - Archer, Trevor K AD - Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02/16/ PY - 2007 DA - 2007 Feb 16 SP - 4400 EP - 4407 VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Acetophenones KW - 0 KW - Benzopyrans KW - Chromatin KW - Enzyme Inhibitors KW - Glucocorticoids KW - Histones KW - Receptors, Glucocorticoid KW - Dexamethasone KW - 7S5I7G3JQL KW - rottlerin KW - E29LP3ZMUH KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Osmotic Pressure KW - Acetophenones -- pharmacology KW - Dexamethasone -- pharmacology KW - Humans KW - Cell Line, Tumor KW - Mice KW - Receptors, Glucocorticoid -- metabolism KW - Glucocorticoids -- pharmacology KW - Phosphorylation -- drug effects KW - Protein Kinase C -- metabolism KW - Protein Kinase C -- antagonists & inhibitors KW - Receptors, Glucocorticoid -- agonists KW - Benzopyrans -- pharmacology KW - Enzyme Inhibitors -- pharmacology KW - Protein Processing, Post-Translational -- drug effects KW - Mammary Tumor Virus, Mouse -- metabolism KW - Promoter Regions, Genetic KW - Chromatin -- metabolism KW - Protein Processing, Post-Translational -- genetics KW - Histones -- metabolism KW - Histones -- genetics KW - Chromatin -- genetics KW - Mammary Tumor Virus, Mouse -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69001146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Osmotic+stress-dependent+repression+is+mediated+by+histone+H3+phosphorylation+and+chromatin+structure.&rft.au=Burkhart%2C+Barbara+A%3BKennett%2C+Sarah+B%3BArcher%2C+Trevor+K&rft.aulast=Burkhart&rft.aufirst=Barbara&rft.date=2007-02-16&rft.volume=282&rft.issue=7&rft.spage=4400&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pattern of subclinical pulmonary dysfunctions in Parkinson's disease and the effect of levodopa. AN - 85396743; pmid-17230476 AB - We performed a detailed evaluation of pulmonary function in 53 patients with idiopathic Parkinson's disease (PD) who did not have symptoms of pulmonary or cardiac dysfunction. There was a significant pulmonary dysfunction of restrictive type which partially responded to levodopa. Compared to men, women were more severely affected. Pulmonary function assessment is recommended in PD, irrespective of severity of disease. JF - Movement disorders : official journal of the Movement Disorder Society AU - Pal, Pramod Kumar AU - Sathyaprabha, Talakad N AU - Tuhina, Prasad AU - Thennarasu, Kandavel AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. pal.pramod@rediffmail.com Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 420 EP - 424 VL - 22 IS - 3 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Antiparkinson Agents: therapeutic use KW - Female KW - Humans KW - *Levodopa: therapeutic use KW - *Lung Diseases: drug therapy KW - Lung Diseases: etiology KW - Male KW - Middle Aged KW - Parkinson Disease: complications KW - *Parkinson Disease: drug therapy KW - Respiratory Function Tests: methods KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396743?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Pattern+of+subclinical+pulmonary+dysfunctions+in+Parkinson%27s+disease+and+the+effect+of+levodopa.&rft.au=Pal%2C+Pramod+Kumar%3BSathyaprabha%2C+Talakad+N%3BTuhina%2C+Prasad%3BThennarasu%2C+Kandavel&rft.aulast=Pal&rft.aufirst=Pramod&rft.date=2007-02-15&rft.volume=22&rft.issue=3&rft.spage=420&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. AN - 70249920; 17312396 AB - Nuclear receptor corepressor (N-CoR) is a critical regulator of neural stem cell differentiation. Nuclear localization of N-CoR is a feature of undifferentiated neural stem cells and cytoplasmic translocation of N-CoR leads to astrocytic differentiation. Comparative proteomic analysis of microdissected glioblastoma multiforme (GBM) specimens and matched normal glial tissue reveals increased expression of N-CoR in GBM. In GBM primary cell cultures, tumor cells with nuclear localization of N-CoR demonstrate an undifferentiated phenotype, but are subject to astroglial differentiation upon exposure to agents promoting phosphorylation of N-CoR and its subsequent translocation to the cytoplasm. Treatment of glioma cell lines with a combination of retinoic acid and low-dose okadaic acid decreases the corepressor effect of N-CoR and has a striking synergistic effect on growth inhibition. The identification of N-CoR in GBM provides insights into the tumorigenesis process and supports the development of differentiation-based therapeutic strategies. JF - Cell cycle (Georgetown, Tex.) AU - Park, Deric M AU - Li, Jie AU - Okamoto, Hiroaki AU - Akeju, Oluwaseun AU - Kim, Stephanie H AU - Lubensky, Irina AU - Vortmeyer, Alexander AU - Dambrosia, James AU - Weil, Robert J AU - Oldfield, Edward H AU - Park, John K AU - Zhuang, Zhengping AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 467 EP - 470 VL - 6 IS - 4 KW - Biomarkers KW - 0 KW - NCOR1 protein, human KW - Nuclear Proteins KW - Nuclear Receptor Co-Repressor 1 KW - Repressor Proteins KW - Okadaic Acid KW - 1W21G5Q4N2 KW - Tretinoin KW - 5688UTC01R KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Tretinoin -- pharmacology KW - Humans KW - Tumor Cells, Cultured KW - Phosphorylation KW - Biomarkers -- analysis KW - Signal Transduction -- drug effects KW - Okadaic Acid -- pharmacology KW - Cell Differentiation -- drug effects KW - Drug Synergism KW - Okadaic Acid -- administration & dosage KW - Protein Transport KW - Nuclear Proteins -- analysis KW - Brain Neoplasms -- pathology KW - Glioblastoma -- pathology KW - Repressor Proteins -- physiology KW - Neoplastic Stem Cells -- pathology KW - Repressor Proteins -- metabolism KW - Brain Neoplasms -- metabolism KW - Repressor Proteins -- analysis KW - Nuclear Proteins -- metabolism KW - Nuclear Proteins -- physiology KW - Neoplastic Stem Cells -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70249920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.atitle=N-CoR+pathway+targeting+induces+glioblastoma+derived+cancer+stem+cell+differentiation.&rft.au=Park%2C+Deric+M%3BLi%2C+Jie%3BOkamoto%2C+Hiroaki%3BAkeju%2C+Oluwaseun%3BKim%2C+Stephanie+H%3BLubensky%2C+Irina%3BVortmeyer%2C+Alexander%3BDambrosia%2C+James%3BWeil%2C+Robert+J%3BOldfield%2C+Edward+H%3BPark%2C+John+K%3BZhuang%2C+Zhengping&rft.aulast=Park&rft.aufirst=Deric&rft.date=2007-02-15&rft.volume=6&rft.issue=4&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=Cell+cycle+%28Georgetown%2C+Tex.%29&rft.issn=1551-4005&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear factor-kappaB in development, prevention, and therapy of cancer. AN - 69041734; 17317814 AB - Nuclear factor-kappaB (NF-kappaB) is a signal transcription factor that has emerged as an important modulator of altered gene programs and malignant phenotype in development of cancer. Major carcinogens and oncogenic viruses induce NF-kappaB activation, and a variety of subsequent oncogenic events contribute to a progressive increase in constitutive NF-kappaB activation as an important common pathway in most forms of cancer. NF-kappaB target genes promote tumor cell proliferation, survival, migration, inflammation, and angiogenesis. Inhibition of NF-kappaB has been found to be an important mechanism of action of steroids, nonsteroidal anti-inflammatory drugs, and natural and synthetic compounds that show therapeutic and preventive activity. Newer agents targeting the proteasome, inhibitor-kappaB kinase, and other upstream kinases involved in NF-kappaB activation have shown anticancer activity in clinical or preclinical studies. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Van Waes, Carter AD - Head and Neck Surgery Branch, National Institute on Deafness and Other Communication Disorders and Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. vanwaesc@nidcd.nih.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1076 EP - 1082 VL - 13 IS - 4 SN - 1078-0432, 1078-0432 KW - NF-kappa B KW - 0 KW - Index Medicus KW - Humans KW - Neoplasms -- therapy KW - Neoplasms -- genetics KW - NF-kappa B -- genetics KW - Neoplasms -- metabolism KW - NF-kappa B -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69041734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Nuclear+factor-kappaB+in+development%2C+prevention%2C+and+therapy+of+cancer.&rft.au=Van+Waes%2C+Carter&rft.aulast=Van+Waes&rft.aufirst=Carter&rft.date=2007-02-15&rft.volume=13&rft.issue=4&rft.spage=1076&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma. AN - 69039440; 17317821 AB - Hepatocellular carcinoma (HCC), a common cancer worldwide, has a dismal outcome partly due to the poor identification of early-stage HCC. Currently, one third of HCC patients present with low serum alpha-fetoprotein (AFP) levels, the only clinically available diagnostic marker for HCC. The aim of this study was to identify new diagnostic molecular markers for HCC, especially for individuals with low serum AFP. We used the microarray technique to determine the expression profiles of 218 HCC specimens from patients with either high or low serum AFP. From the microarray study, we selected five candidate genes (i.e., GPC3, PEG10, MDK, SERPINI1, and QP-C), which were overexpressed in HCCs. Using quantitative real-time PCR analyses, we validated the expression of these five genes in 50 AFP-normal and 8 AFP-positive HCC specimens and 36 cirrhotic noncancerous hepatic specimens, which include 52 independent specimens not used in microarray analysis. A significant increase in the expression of the five candidate genes could be detected in most of the HCC samples, including those with normal serum AFP and small tumors. GPC3, MDK, and SERPINI1 encode known serum proteins. Consistently, a significant increase in serum midkine, encoded by MDK, was associated with HCC patients, including those with normal serum AFP. Using prediction analysis of microarray, we showed that a combined score of these five genes can accurately classify noncancerous hepatic tissues (100%) and HCC (71%). We suggest that a diagnostic signature approach using a combined score of these five biomarkers rather than a single marker may improve the prediction accuracy of HCC patients, including those with normal serum AFP and smaller-sized tumors. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Jia, Hu-Liang AU - Ye, Qing-Hai AU - Qin, Lun-Xiu AU - Budhu, Anuradha AU - Forgues, Marshonna AU - Chen, Yidong AU - Liu, Yin-Kun AU - Sun, Hui-Chuan AU - Wang, Lu AU - Lu, Hong-Zhou AU - Shen, Fang AU - Tang, Zhao-You AU - Wang, Xin Wei AD - Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4258, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1133 EP - 1139 VL - 13 IS - 4 SN - 1078-0432, 1078-0432 KW - Biomarkers, Tumor KW - 0 KW - Carrier Proteins KW - GPC3 protein, human KW - Glypicans KW - MDK protein, human KW - Nerve Growth Factors KW - Neuropeptides KW - PEG10 protein, human KW - Proteins KW - Serpins KW - alpha-Fetoproteins KW - neuroserpin KW - ubiquinone-binding proteins KW - Index Medicus KW - Glypicans -- genetics KW - Glypicans -- biosynthesis KW - Oligonucleotide Array Sequence Analysis KW - Carrier Proteins -- genetics KW - Humans KW - Serpins -- biosynthesis KW - Aged KW - Neuropeptides -- biosynthesis KW - Proteins -- genetics KW - Carrier Proteins -- biosynthesis KW - Gene Expression Profiling KW - Nerve Growth Factors -- biosynthesis KW - Nerve Growth Factors -- genetics KW - Polymerase Chain Reaction -- methods KW - Adult KW - Middle Aged KW - Adolescent KW - Serpins -- genetics KW - alpha-Fetoproteins -- metabolism KW - Female KW - Male KW - Neuropeptides -- genetics KW - Biomarkers, Tumor -- genetics KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Biomarkers, Tumor -- biosynthesis KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69039440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Gene+expression+profiling+reveals+potential+biomarkers+of+human+hepatocellular+carcinoma.&rft.au=Laughon%2C+Barbara+E&rft.aulast=Laughon&rft.aufirst=Barbara&rft.date=2007-03-01&rft.volume=7&rft.issue=6&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=Current+Topics+in+Medicinal+Chemistry&rft.issn=15680266&rft_id=info:doi/10.2174%2F156802607780059736 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-18 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of CCAAT/enhancer binding protein family DNA binding in mouse epidermis prevents and regresses papillomas. AN - 69020296; 17308129 AB - The CCAAT/enhancer binding proteins (C/EBP) are a family of B-ZIP DNA binding proteins that act as transcription factors to regulate growth and differentiation of many cell types, including keratinocytes. To examine the consequences of inhibiting the C/EBP family of transcription factors in skin, we generated transgenic mice that use the tetracycline system to conditionally express A-C/EBP, a dominant negative that inhibits the DNA binding of C/EBP family members. We expressed A-C/EBP in the basal layer of the skin epidermis during a two-step skin carcinogenesis protocol. A-C/EBP expression caused hyperplasia of the basal epidermis and increased apoptosis in the suprabasal epidermis. The mice developed fewer papillomas and had systemic hair loss. A-C/EBP expression caused C/EBPbeta protein to disappear whereas C/EBPalpha, p53, Bax, and caspase-3 protein levels were dramatically up-regulated in the suprabasal layer. Primary keratinocytes recapitulate the A-C/EBP induction of cell growth and increase in p53 protein. A-C/EBP expression after papilloma development caused the papillomas to regress with an associated increase in apoptosis and up-regulation of p53 protein. Furthermore, A-C/EBP-expressing mice heterozygous for p53 were more susceptible to papilloma formation, suggesting that the suppression of papilloma formation has a p53-dependent mechanism. These results implicate DNA binding of C/EBP family members as a potential molecular therapeutic target. JF - Cancer research AU - Oh, Won Jun AU - Rishi, Vikas AU - Orosz, Andras AU - Gerdes, Michael J AU - Vinson, Charles AD - Laboratory of Metabolism, National Cancer Institute, Center for Cancer Research/NIH, Bethesda, MD 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 1867 EP - 1876 VL - 67 IS - 4 SN - 0008-5472, 0008-5472 KW - CCAAT-Enhancer-Binding Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Cell Growth Processes -- physiology KW - Skin -- metabolism KW - Apoptosis -- physiology KW - Skin -- pathology KW - Keratinocytes -- cytology KW - Mice KW - Keratinocytes -- metabolism KW - Mice, Transgenic KW - CCAAT-Enhancer-Binding Proteins -- biosynthesis KW - Papilloma -- prevention & control KW - Papilloma -- pathology KW - DNA -- metabolism KW - CCAAT-Enhancer-Binding Proteins -- metabolism KW - Skin Neoplasms -- pathology KW - CCAAT-Enhancer-Binding Proteins -- antagonists & inhibitors KW - CCAAT-Enhancer-Binding Proteins -- genetics KW - Skin Neoplasms -- prevention & control KW - Skin Neoplasms -- metabolism KW - Papilloma -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69020296?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Inhibition+of+CCAAT%2Fenhancer+binding+protein+family+DNA+binding+in+mouse+epidermis+prevents+and+regresses+papillomas.&rft.au=Oh%2C+Won+Jun%3BRishi%2C+Vikas%3BOrosz%2C+Andras%3BGerdes%2C+Michael+J%3BVinson%2C+Charles&rft.aulast=Oh&rft.aufirst=Won&rft.date=2007-02-15&rft.volume=67&rft.issue=4&rft.spage=1867&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic mechanisms of susceptibility to oxidative lung injury in mice. AN - 68974066; 17275675 AB - Genetic background is a known predisposing risk factor for many acute and chronic pulmonary disorders and responses to environmental oxidants. Variation in lung injury responses to oxidative stimuli such as ozone, particles, hyperoxia, and chemotherapeutic agents between genetically standardized inbred mouse strains has been demonstrated. In this review, we discuss quantitative trait loci (QTLs) which contain candidate genes that confer differential susceptibility to oxidative stimuli between strains in mouse models of airway toxicity and disease. We addressed multiple inflammatory, immunity, and antioxidant genes identified as candidate genetic determinants following these strategies, which include tumor necrosis factor (Tnf), toll-like receptor 4 (Tlr4), and the transcription factor NF-E2, related factor 2 (Nrf2). Mice with targeted deletion of these and related genes have provided initial proof of concept for their importance in the respective models. Interestingly, a few regions of the genome appear to have important roles in determining susceptibility to a number of stimuli which may suggest common genetic mechanisms in mice. Though more complete examination of functional association is required, results have potential implications for the role of these candidate genes in the pathogenesis of human pulmonary diseases including asthma, acute respiratory distress syndrome (ARDS), idiopathic pulmonary fibrosis (IPF), and emphysema. JF - Free radical biology & medicine AU - Cho, Hye-Youn AU - Kleeberger, Steven R AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. cho2@niehs.nih.gov Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 433 EP - 445 VL - 42 IS - 4 SN - 0891-5849, 0891-5849 KW - Index Medicus KW - Animals KW - Base Sequence KW - Mice KW - Species Specificity KW - Lung Diseases -- genetics KW - Oxidative Stress KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Free+radical+biology+%26+medicine&rft.atitle=Genetic+mechanisms+of+susceptibility+to+oxidative+lung+injury+in+mice.&rft.au=Cho%2C+Hye-Youn%3BKleeberger%2C+Steven+R&rft.aulast=Cho&rft.aufirst=Hye-Youn&rft.date=2007-02-15&rft.volume=42&rft.issue=4&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Free+radical+biology+%26+medicine&rft.issn=08915849&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-26 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model. AN - 68925042; 17230417 AB - To better define the contribution of edema toxins (ETx) and lethal toxins (LeTx) to shock with Bacillus anthracis, recombinant preparations of each were investigated alone or together in rats. Lethal dose ranges (0%-100% lethality) of ETx (200-800 microg/kg as a 24-h infusion) were higher than those of LeTx (12.5-200 microg/kg) (P<.0001). However, compared with LeTx, similarly lethal ETx doses produced earlier and greater reductions in mean blood pressure (MBP) and increased, rather than decreased, heart rate (HR) (P<.05 for all). Combining either similar weight or lethal doses of ETx and LeTx increased the hazard ratio for death (log +/- standard error) similar to the sum calculated with the toxin's effects alone (2.6+/-1.1 observed vs. 2.9+/-1.0 calculated for similar weight and 3.1+/-1.0 vs. 3.9+/-1.5 for similar lethal doses; P=.5 for both). Early (< or =10 h) and late during infusion, ETx and LeTx together also altered MBP and HR in patterns consistent with the sum of their individual effects. ETx was approximately 10 times less lethal than LeTx but produced greater hypotension and added to the latter's harmful effects. These findings suggest that it may be appropriate for antitoxin therapies for B. anthracis to target both ETx and LeTx. JF - The Journal of infectious diseases AU - Cui, Xizhong AU - Li, Yan AU - Li, Xuemei AU - Laird, Michael W AU - Subramanian, Mani AU - Moayeri, Mahtab AU - Leppla, Stephen H AU - Fitz, Yvonne AU - Su, Junwu AU - Sherer, Kevin AU - Eichacker, Peter Q AD - Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02/15/ PY - 2007 DA - 2007 Feb 15 SP - 572 EP - 580 VL - 195 IS - 4 SN - 0022-1899, 0022-1899 KW - Antigens, Bacterial KW - 0 KW - Bacterial Toxins KW - Cytokines KW - Hemoglobins KW - Recombinant Proteins KW - Virulence Factors KW - anthrax toxin KW - Nitric Oxide KW - 31C4KY9ESH KW - Abridged Index Medicus KW - Index Medicus KW - Recombinant Proteins -- toxicity KW - Rats KW - Cytokines -- blood KW - Animals KW - Rats, Sprague-Dawley KW - Hemoglobins -- analysis KW - Heart Rate KW - Blood Pressure KW - Nitric Oxide -- blood KW - Disease Models, Animal KW - Time Factors KW - Leukocyte Count KW - Survival Analysis KW - Antigens, Bacterial -- toxicity KW - Shock -- microbiology KW - Anthrax -- physiopathology KW - Virulence Factors -- toxicity KW - Bacillus anthracis -- pathogenicity KW - Anthrax -- pathology KW - Bacterial Toxins -- toxicity KW - Anthrax -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Bacillus+anthracis+edema+and+lethal+toxin+have+different+hemodynamic+effects+but+function+together+to+worsen+shock+and+outcome+in+a+rat+model.&rft.au=Cui%2C+Xizhong%3BLi%2C+Yan%3BLi%2C+Xuemei%3BLaird%2C+Michael+W%3BSubramanian%2C+Mani%3BMoayeri%2C+Mahtab%3BLeppla%2C+Stephen+H%3BFitz%2C+Yvonne%3BSu%2C+Junwu%3BSherer%2C+Kevin%3BEichacker%2C+Peter+Q&rft.aulast=Cui&rft.aufirst=Xizhong&rft.date=2007-02-15&rft.volume=195&rft.issue=4&rft.spage=572&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-19 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Infect Dis. 2007 Feb 15;195(4):471-3 [17230405] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inflammation and IGF-I activate the Akt pathway in breast cancer. AN - 68387809; 17096325 AB - Akt signaling may promote breast cancer progression and poor disease outcome. We hypothesized that serum insulin-like growth factor I (IGF-I) and a proinflammatory tumor environment induce phosphorylation of Akt and downstream targets of Akt in breast cancer. We studied the relationship between Akt pathway activation, IGF-I and markers of inflammation, e.g., nitric oxide synthase-2 (NOS2), cyclooxygenase-2 (COX2) and tumor phagocyte density, in 248 breast tumors. We also examined the association of Akt phosphorylation with breast cancer survival. We observed that phosphorylation of Akt, BAD and caspase-9 correlated strongly with the expression of the 2 proinflammatory enzymes, NOS2 and COX2, in breast tumors (p < 0.001; Spearman rank correlation). Both NOS2 and COX2 expression were independently associated with Akt phosphorylation in the multivariate analysis. Serum IGF-I concentrations and the IGF-I/IGFBP3 ratio correlated with Akt phosphorylation at Thr308 and Ser473 in breast tumors (p 90-fold, whereas TNF-alpha-mediated activation was inhibited by >30%. A reporter gene assay showed that HU and IL-6 synergized to activate HIV promoter activity via the Sp1 binding site. Electrophoretic mobility shift and supershift assays revealed increased binding of the Sp1 and Sp3 transcription factors to this region. Western blot analysis showed that HU and IL-6 co-stimulation resulted in increased levels of Sp1 and Sp3 proteins. In contrast, treatment with HU plus TNF-alpha down-regulated the expression of NF-kappaB. These findings suggest that Sp1/Sp3 is involved in controlling the HU/IL-6-induced reactivation of HIV-1 in latently infected cells. JF - The Journal of biological chemistry AU - Oguariri, Raphael M AU - Brann, Terrence W AU - Imamichi, Tomozumi AD - Laboratory of Human Retrovirology, Clinical Services Program, Science Applications International Corporation-Frederick Inc., NCI-Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3594 EP - 3604 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Interleukin-6 KW - 0 KW - Sp1 Transcription Factor KW - Sp3 Transcription Factor KW - 148710-94-5 KW - Hydroxyurea KW - X6Q56QN5QC KW - Index Medicus KW - Virus Latency -- physiology KW - Virus Replication -- drug effects KW - Humans KW - Virus Latency -- drug effects KW - Cell Line, Tumor KW - Virus Replication -- physiology KW - Drug Synergism KW - Virus Activation -- physiology KW - Virus Activation -- drug effects KW - Interleukin-6 -- physiology KW - Sp1 Transcription Factor -- physiology KW - Monocytes -- metabolism KW - Monocytes -- drug effects KW - Hydroxyurea -- pharmacology KW - Monocytes -- virology KW - HIV-1 -- physiology KW - Sp3 Transcription Factor -- physiology KW - HIV-1 -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Hydroxyurea+and+interleukin-6+synergistically+reactivate+HIV-1+replication+in+a+latently+infected+promonocytic+cell+line+via+SP1%2FSP3+transcription+factors.&rft.au=Oguariri%2C+Raphael+M%3BBrann%2C+Terrence+W%3BImamichi%2C+Tomozumi&rft.aulast=Oguariri&rft.aufirst=Raphael&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3594&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The inner loop of tetraspanins CD82 and CD81 mediates interactions with human T cell lymphotrophic virus type 1 Gag protein. AN - 68974447; 17166843 AB - The tetraspanin superfamily proteins play important roles in organizing membrane protein complexes, modulating integrin function, and controlling T cell adhesion. Tetraspanins such as CD82 contain two extracellular loops with its N terminus, C terminus, and inner loop exposed to the cytoplasm. The matrix (MA) domain of human T cell lymphotrophic virus, type 1 (HTLV-1), Gag interacts with the cytoplasmic face of the plasma membrane and is concentrated at tetraspanin-enriched microdomains. To understand the basis of this association, we generated site-directed mutations in the various domains of CD82 and used coimmunoprecipitation and colocalization approaches to examine interactions with HTLV-1 MA. The large extracellular loop of CD82, which is important for interactions with integrins, was not required for the association with HTLV-1 MA. The cytoplasmic N terminus and C terminus of CD82 were also dispensable for CD82-MA interactions. In contrast, mutations of conserved amino acids in the inner loop of CD82 or of palmitoylated cysteines that flank the inner loop diminished CD82 association with MA. HTLV-1 MA also interacted with the inner loop of CD81. Thus, association of HTLV-1 Gag with tetraspanin-enriched microdomains is mediated by the inner loops of CD81 and CD82. JF - The Journal of biological chemistry AU - Mazurov, Dmitriy AU - Heidecker, Gisela AU - Derse, David AD - HIV Drug Resistance Program, NCI-Frederick, Frederick, Maryland 21702-1201, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3896 EP - 3903 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Antigens, CD KW - 0 KW - Antigens, CD81 KW - Antigens, CD82 KW - CD81 protein, human KW - CD82 protein, human KW - Gene Products, gag KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Structure, Tertiary -- genetics KW - HeLa Cells KW - Humans KW - Membrane Microdomains -- physiology KW - Jurkat Cells KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Membrane Microdomains -- genetics KW - Membrane Microdomains -- chemistry KW - Cell Line KW - Human T-lymphotropic virus 1 -- physiology KW - Antigens, CD82 -- genetics KW - Human T-lymphotropic virus 1 -- genetics KW - Antigens, CD -- physiology KW - Human T-lymphotropic virus 1 -- chemistry KW - Antigens, CD82 -- chemistry KW - Antigens, CD82 -- physiology KW - Antigens, CD -- chemistry KW - Antigens, CD -- genetics KW - Gene Products, gag -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68974447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=The+inner+loop+of+tetraspanins+CD82+and+CD81+mediates+interactions+with+human+T+cell+lymphotrophic+virus+type+1+Gag+protein.&rft.au=Mazurov%2C+Dmitriy%3BHeidecker%2C+Gisela%3BDerse%2C+David&rft.aulast=Mazurov&rft.aufirst=Dmitriy&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3896&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. AN - 68973905; 17148450 AB - Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase consisting of two isoforms, alpha and beta. The activities of GSK-3 are regulated negatively by serine phosphorylation but positively by tyrosine phosphorylation. GSK-3 inactivation has been proposed as a mechanism to promote neuronal survival. We used GSK-3 isoform-specific small interfering RNAs, dominant-negative mutants, or pharmacological inhibitors to search for functions of the two GSK-3 isoforms in regulating neuronal survival in cultured cortical neurons in response to glutamate insult or during neuronal maturation/aging. Surprisingly, RNA interference-induced depletion of either isoform was sufficient to block glutamate-induced excitotoxicity, and the resulting neuroprotection was associated with enhanced N-terminal serine phosphorylation in both GSK-3 isoforms. However, GSK-3beta depletion was more effective than GSK-3alpha depletion in suppressing spontaneous neuronal death in extended culture. This phenomenon is likely due to selective and robust inhibition of GSK-3beta activation resulting from GSK-3beta Ser9 dephosphorylation during the course of spontaneous neuronal death. GSK-3alpha silencing resulted in reduced tyrosine phosphorylation of GSK-3beta, suggesting that tyrosine phosphorylation is also a critical autoregulatory event. Interestingly, GSK-3 inhibitors caused a rapid and long-lasting increase in GSK-3alpha Ser21 phosphorylation levels, followed by a delayed increase in GSK-3beta Ser9 phosphorylation and a decrease in GSK-3alpha Tyr279 and GSK-3beta Tyr216 phosphorylation, thus implying additional levels of GSK-3 autoregulation. Taken together, our results underscore important similarities and dissimilarities of GSK-3alpha and GSK-3beta in the roles of cell survival as well as their distinct modes of regulation. The development of GSK-3 isoform-specific inhibitors seems to be warranted for treating GSK-3-mediated pathology. JF - The Journal of biological chemistry AU - Liang, Min-Huei AU - Chuang, De-Maw AD - Molecular Neurobiology Section, National Institute of Mental Health, Bethesda, Maryland 20892-1363, USA. Y1 - 2007/02/09/ PY - 2007 DA - 2007 Feb 09 SP - 3904 EP - 3917 VL - 282 IS - 6 SN - 0021-9258, 0021-9258 KW - Isoenzymes KW - 0 KW - RNA, Small Interfering KW - Glutamic Acid KW - 3KX376GY7L KW - Glycogen Synthase Kinase 3 beta KW - EC 2.7.11.1 KW - Gsk3b protein, rat KW - Glycogen Synthase Kinase 3 KW - EC 2.7.11.26 KW - glycogen synthase kinase 3 alpha KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Cerebral Cortex -- drug effects KW - Cell Survival -- genetics KW - Cerebral Cortex -- enzymology KW - Gene Silencing KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Phosphorylation -- drug effects KW - Rats KW - Glutamic Acid -- toxicity KW - Isoenzymes -- physiology KW - Cell Survival -- drug effects KW - Transfection KW - Cells, Cultured KW - RNA, Small Interfering -- pharmacology KW - Organ Culture Techniques KW - Mutation KW - Cell Survival -- physiology KW - Glycogen Synthase Kinase 3 -- physiology KW - Glycogen Synthase Kinase 3 -- genetics KW - Neurons -- drug effects KW - Neurons -- cytology KW - Neurons -- enzymology KW - Glycogen Synthase Kinase 3 -- metabolism KW - Glycogen Synthase Kinase 3 -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68973905?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Regulation+and+function+of+glycogen+synthase+kinase-3+isoforms+in+neuronal+survival.&rft.au=Liang%2C+Min-Huei%3BChuang%2C+De-Maw&rft.aulast=Liang&rft.aufirst=Min-Huei&rft.date=2007-02-09&rft.volume=282&rft.issue=6&rft.spage=3904&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-23 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Symptom Cluster of Fatigue and Depression in HIV/AIDS AN - 61398791; 200800677 AB - Fatigue and depression are among the most frequently rated symptoms of people with HIV/AIDS. This study aimed: (1) to describe severity of fatigue and depression in an outpatient sample (n = 372) of men and women with HIV/AIDS, (2) to evaluate sensitivity and discriminant validity for two fatigue and three depression scales and (3) to investigate whether fatigue and depression are conceptually distinct concepts or reciprocally dependent. This was a secondary analysis of a descriptive, cross-sectional study with convenience sampling. Fatigue was assessed with the fatigue factor score of the revised Sign and Symptom Checklist HIV (SSC-HIVrev), and the fatigue scale of the Self-Care Symptom Management for Living with HIV/AIDS Scale SCSMS-F). Depression was assessed with the depression factor score of the SSC-HIVrev, the depression scale of the SCSMC-D and the Center for Epidemiologic Studies Depression Scale (CES-D). Most of the participants were male (67%), with a mean age of 39.9 years, and of African American decent (73%). Dependent on the instrument, the average fatigue severity was moderate and the average depression severity was moderate to severe. Women experienced higher fatigue and depression severity scores than men. The scores on the same instruments for fatigue and depression showed significant correlations (SSC-HIVrev fatigue and depression r = 0.62; SCSMS fatigue and depression r = 0.64), indicating that both concepts are closely related. Patients seeking help for fatigue and/or depression should always be evaluated for both symptoms. Future research is needed to identify dimensions in different fatigue and depression scales in order to differentiate the impact of both symptoms on people living with HIV/AIDS. Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Prevention & Intervention in the Community AU - Voss, Joachim AU - Portillo, Carmen AU - Holzemer, William AU - Dodd, Marylin AD - RN, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-1382 Y1 - 2007/02/08/ PY - 2007 DA - 2007 Feb 08 SP - 19 EP - 34 PB - Haworth Press, Binghamton NY VL - 33 IS - 1-2 SN - 1085-2352, 1085-2352 KW - Help Seeking Behavior KW - Black Americans KW - Fatigue KW - Depression (Psychology) KW - Scales KW - Acquired Immune Deficiency Syndrome KW - article KW - 6126: acquired immune deficiency syndrome (AIDS) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61398791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocialservices&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.atitle=Symptom+Cluster+of+Fatigue+and+Depression+in+HIV%2FAIDS&rft.au=Voss%2C+Joachim%3BPortillo%2C+Carmen%3BHolzemer%2C+William%3BDodd%2C+Marylin&rft.aulast=Voss&rft.aufirst=Joachim&rft.date=2007-02-08&rft.volume=33&rft.issue=1-2&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Journal+of+Prevention+%26+Intervention+in+the+Community&rft.issn=10852352&rft_id=info:doi/10.1300%2FJ005v33n01_03 LA - English DB - Social Services Abstracts N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - SubjectsTermNotLitGenreText - Depression (Psychology); Fatigue; Acquired Immune Deficiency Syndrome; Black Americans; Help Seeking Behavior; Scales DO - http://dx.doi.org/10.1300/J005v33n01_03 ER - TY - CPAPER T1 - Standard Gradient Echo (GRE) is Far Superior to Other Susceptibility-Weighted MR Sequences for Identifying Intracranial Hemorrhage T2 - 2007 International Stroke Conference AN - 40526253; 4519624 JF - 2007 International Stroke Conference AU - Fifi, Johanna T AU - Butman, John A AU - Warach, Steven AU - Luby, Marie AU - Chalela, Julio AU - Saver, Jeffrey L AU - Kidwell, Chelsea S Y1 - 2007/02/07/ PY - 2007 DA - 2007 Feb 07 KW - Hemorrhage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+International+Stroke+Conference&rft.atitle=Standard+Gradient+Echo+%28GRE%29+is+Far+Superior+to+Other+Susceptibility-Weighted+MR+Sequences+for+Identifying+Intracranial+Hemorrhage&rft.au=Fifi%2C+Johanna+T%3BButman%2C+John+A%3BWarach%2C+Steven%3BLuby%2C+Marie%3BChalela%2C+Julio%3BSaver%2C+Jeffrey+L%3BKidwell%2C+Chelsea+S&rft.aulast=Fifi&rft.aufirst=Johanna&rft.date=2007-02-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+International+Stroke+Conference&rft.issn=&rft_id=info:doi/ L2 - http://strokeconference.americanheart.org/portal/strokeconference/sc/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Second Cancer Incidence and Cause-Specific Mortality Among 3104 Patients With Hairy Cell Leukemia: A Population-Based Study AN - 19586294; 7289326 AB - BACKGROUND: The introduction of new treatments for hairy cell leukemia has resulted in improved patient survival but also engendered increasing concern about the possibility of excess second cancers. The available evidence is conflicting, with most risk estimates based on sparse numbers. To our knowledge, no study has evaluated cause-specific mortality in patients with hairy cell leukemia. METHODS: We quantified second cancer incidence and cause-specific mortality among 3104 two-month survivors of hairy cell leukemia who were reported to 16 population-based registries in the Surveillance, Epidemiology and End Results (SEER) Program between 1973 and 2002. Standardized incidence ratios (SIRs) and standardized mortality ratios (SMRs) were used to quantify the risk of second cancers and causes of death, respectively. The cumulative probability of a second cancer among survivors of hairy cell leukemia was calculated using a competing risk model. All statistical tests were two-sided. RESULTS: Mean follow-up of hairy cell leukemia survivors was 6.5 years (range, 2 months-29.3 years). Second cancer risk was statistically significantly elevated (SIR = 1.24, 95% confidence interval [CI] = 1.11 to 1.37) compared with the general population. Survivors had statistically significantly higher risks of Hodgkin lymphoma (SIR = 6.61, 95% CI = 2.13 to 15.42), non-Hodgkin lymphoma (SIR = 5.03, 95% CI = 3.77 to 6.58), and thyroid cancer (SIR = 3.56, 95% CI = 1.30 to 7.74) and a lower risk of lung cancer (SIR = 0.63, 95% CI = 0.42 to 0.90). The cumulative probability of all second cancers was estimated to be 31.9% (95% CI = 26.2 to 37.6) 25 years after hairy cell leukemia diagnosis. Among 10 000 hairy cell leukemia patients, a total excess of about 34 cancers, including 21 non-Hodgkin lymphomas, 2 Hodgkin lymphomas, and 7 solid tumors (including 2 thyroid cancers), might be observed per year. Deaths due to solid tumors were not elevated compared with the general population (SMR = 0.9), and there were statistically significant deficits in mortality due to both cardiovascular (SMR = 0.67, 95% CI = 0.56 to 0.80) and cerebrovascular (SMR = 0.61, 95% CI = 0.38 to 0.93) disease. CONCLUSIONS: Patients with hairy cell leukemia are at increased risk of Hodgkin lymphoma, non-Hodgkin lymphoma, and thyroid cancer. The decrease in lung cancer incidence and smoking-associated vascular mortality may reflect an inverse association of tobacco use with hairy cell leukemia. Future studies should address the roles of immunologic impairment inherent to hairy cell leukemia, treatment modalities, and other factors as codeterminants of morbidity and mortality in hairy cell leukemia survivors. JF - Journal of the National Cancer Institute AU - Hisada, Michie AU - Chen, Bingshu E AU - Jaffe, Elaine S AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD (MH, BEC, LBT) Y1 - 2007/02/07/ PY - 2007 DA - 2007 Feb 07 SP - 215 EP - 222 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 3 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Risk assessment KW - Cell survival KW - Mortality KW - Hodgkin's disease KW - Solid tumors KW - Thyroid KW - Statistical analysis KW - Population studies KW - Morbidity KW - Leukemia KW - Epidemiology KW - Risk factors KW - thyroid cancer KW - Tobacco KW - survival KW - lymphoma KW - Hairy cell leukemia KW - Lung cancer KW - Vascular system KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19586294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Second+Cancer+Incidence+and+Cause-Specific+Mortality+Among+3104+Patients+With+Hairy+Cell+Leukemia%3A+A+Population-Based+Study&rft.au=Hisada%2C+Michie%3BChen%2C+Bingshu+E%3BJaffe%2C+Elaine+S%3BTravis%2C+Lois+B&rft.aulast=Hisada&rft.aufirst=Michie&rft.date=2007-02-07&rft.volume=99&rft.issue=3&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Risk assessment; Mortality; Hodgkin's disease; Solid tumors; Statistical analysis; Population studies; Morbidity; Epidemiology; Risk factors; thyroid cancer; Tobacco; Hairy cell leukemia; Vascular system; Lung cancer; Leukemia; Thyroid; survival; lymphoma ER - TY - CPAPER T1 - Deoxyuracils in Immunoglobulin Genes from Germinal Center B Cells T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40534110; 4522435 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Gearhart, Patricia J Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Lymphocytes B KW - Germinal centers KW - Immunoglobulins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Deoxyuracils+in+Immunoglobulin+Genes+from+Germinal+Center+B+Cells&rft.au=Gearhart%2C+Patricia+J&rft.aulast=Gearhart&rft.aufirst=Patricia&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Damage and Oncogenic Stress: Barriers to Chromosomal Translocations T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40533022; 4522487 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Nussenzweig, Andre Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Translocation KW - Stress KW - Chromosome translocations KW - DNA damage KW - Barriers KW - Chromosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533022?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=DNA+Damage+and+Oncogenic+Stress%3A+Barriers+to+Chromosomal+Translocations&rft.au=Nussenzweig%2C+Andre&rft.aulast=Nussenzweig&rft.aufirst=Andre&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - FcaRIIB1 Regulates Plasma Cell Apoptosis and Differentiation through a c-Abl-dependent Pathway T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40532193; 4522480 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Tzeng, Shiang-Jong Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Plasma cells KW - Differentiation KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=FcaRIIB1+Regulates+Plasma+Cell+Apoptosis+and+Differentiation+through+a+c-Abl-dependent+Pathway&rft.au=Tzeng%2C+Shiang-Jong&rft.aulast=Tzeng&rft.aufirst=Shiang-Jong&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An shRNA Achilles heel Screen Reveals the Requirement for IRF4 Expression in Plasma Cells and Multiple Myleoma T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529915; 4522473 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Shaffer, Arthur L Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Plasma cells KW - Interferon regulatory factor 4 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=An+shRNA+Achilles+heel+Screen+Reveals+the+Requirement+for+IRF4+Expression+in+Plasma+Cells+and+Multiple+Myleoma&rft.au=Shaffer%2C+Arthur+L&rft.aulast=Shaffer&rft.aufirst=Arthur&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural and Transcriptional Changes that Accompany IgH Gene Rearrangements T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529909; 4522421 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Sen, Ranjan Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Transcription KW - Immunoglobulins KW - Gene rearrangement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Structural+and+Transcriptional+Changes+that+Accompany+IgH+Gene+Rearrangements&rft.au=Sen%2C+Ranjan&rft.aulast=Sen&rft.aufirst=Ranjan&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Essential Role of IL-21 for Plasma Cell Generation during T Cell- B Cell Collaboration T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529717; 4522468 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Ettinger, Rachel C Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Lymphocytes B KW - Interleukin 21 KW - Plasma cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Essential+Role+of+IL-21+for+Plasma+Cell+Generation+during+T+Cell-+B+Cell+Collaboration&rft.au=Ettinger%2C+Rachel+C&rft.aulast=Ettinger&rft.aufirst=Rachel&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Loss of Function RNA Interference Screen Identifies Genes Involve in Multiple Myeloma Proliferation and Survival T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40529352; 4522502 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Lamy, Laurence Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Survival KW - Multiple myeloma KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529352?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=A+Loss+of+Function+RNA+Interference+Screen+Identifies+Genes+Involve+in+Multiple+Myeloma+Proliferation+and+Survival&rft.au=Lamy%2C+Laurence&rft.aulast=Lamy&rft.aufirst=Laurence&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR7 Gene Dosage is Critical for Autoantibody Production and Pathology in Mouse Models of Lupus T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40528693; 4522507 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Deane, Jonathan A Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Pathology KW - Autoantibodies KW - Gene dosage KW - Toll-like receptors KW - TLR7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=TLR7+Gene+Dosage+is+Critical+for+Autoantibody+Production+and+Pathology+in+Mouse+Models+of+Lupus&rft.au=Deane%2C+Jonathan+A&rft.aulast=Deane&rft.aufirst=Jonathan&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Loss of Function RNA Interference Screens for Molecular Targets in Lymphoid Malignancies T2 - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AN - 40526435; 4522492 JF - 2007 Keystone Symposia on Biology of B Cells in Health and Disease (B5) AU - Staudt, Louis M Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 KW - Malignancy KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.atitle=Loss+of+Function+RNA+Interference+Screens+for+Molecular+Targets+in+Lymphoid+Malignancies&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2007-02-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Biology+of+B+Cells+in+Health+and+Disease+%28B5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Nanostructure Design Using Protein Building Blocks Enhanced by Conformation ally Constrained Synthetic Residues AN - 20394730; 7728872 AB - Increasing efforts are being invested in the construction of nanostructures with desired shapes and physical and chemical properties. Our strategy involves nanostructure design using naturally occurring protein building blocks. Inspection of the protein structural database (PDB) reveals the richness of the conformations, shapes, and chemistries of proteins and their building blocks. To increase the population of the native fold in the selected building block, we mutate natural residues by engineered, constrained residues that restrict the conformational freedom at the targeted site and have favorable interactions, geometry, and size. Here, as a model system, we construct nanotubes using building blocks from left-handed beta -helices which are commonly occurring repeat protein architectures. We pick two-turn beta -helical segments, duplicate and stack them, and using all-atom molecular dynamics simulations (MD) with explicit solvent probe the structural stability of these nanotubular structures as indicated by then-capacity to retain the initial organization and their conformational dynamics. Comparison of the results for the wild-type and mutated sequences shows that the introduction of the conformationally restricted 1-aminocyclopropanecarboxylic acid (Ac sub(3)c) residue in loop regions greatly enhances the stability of beta -helix nanotubes. The Ac sub(3)c geometrical confinement effect is sequence-specific and position-specific. The achievement of high stability of nanotubular structures originates not only from the reduction of mobility at the mutation site induced by Ac sub(3)c but also from stabilizing association forces between building blocks such as hydrogen bonds and hydrophobic contacts. For the selected synthetic residue, similar size, hydrophobicity, and backbone conformational tendencies are desirable as in the Ac sub(3)c. JF - Biochemistry (Washington) AU - Zheng, J AU - Zanuy, D AU - Haspel, N AU - Tsai, C-J AU - Aleman, C AU - Nussinov, R AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-FCRDC, Frederick, Maryland 21702, USA Y1 - 2007/02/06/ PY - 2007 DA - 2007 Feb 06 SP - 1205 EP - 1218 VL - 46 IS - 5 SN - 0006-2960, 0006-2960 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Handedness KW - Mobility KW - Hydrogen bonding KW - Solvents KW - nanotubes KW - Hydrophobicity KW - Mutation KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20394730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Nanostructure+Design+Using+Protein+Building+Blocks+Enhanced+by+Conformation+ally+Constrained+Synthetic+Residues&rft.au=Zheng%2C+J%3BZanuy%2C+D%3BHaspel%2C+N%3BTsai%2C+C-J%3BAleman%2C+C%3BNussinov%2C+R&rft.aulast=Zheng&rft.aufirst=J&rft.date=2007-02-06&rft.volume=46&rft.issue=5&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi061674a LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hydrophobicity; nanotubes; Hydrogen bonding; Mobility; Solvents; Handedness; Databases; Mutation DO - http://dx.doi.org/10.1021/bi061674a ER - TY - JOUR T1 - Down-regulation of DNA polymerase beta accompanies somatic hypermutation in human BL2 cell lines. AN - 68426730; 17127106 AB - Somatic hypermutation (SHM) is a fundamental process in immunoglobulin gene maturation that results in increased affinity of antibodies toward antigens. In one hypothesis explaining SHM in human B cells, the process is initiated by enzymatic deamination of cytosine to uracil in the immunoglobulin gene V-region and this in turn triggers mutation-prone forms of uracil-DNA base excision repair (BER). Yet, an uncertainty with this model is that BER of uracil-DNA in mammalian cells is generally error-free, wherein DNA polymerase beta (pol beta) conducts gap-filling synthesis by insertion of bases according to Watson-Crick rules. To evaluate this inconsistency, we examined pol beta expression in various SHM proficient human BL2 cell line subclones. We report that expression of pol beta in SHM proficient cell lines was strongly down-regulated. In contrast, in other BL2 subclones, we found that SHM was deficient and that pol beta expression was much higher than in the SHM proficient subclones. We also found that overexpression of recombinant human pol beta in a SHM proficient subclone abrogated its capacity for SHM. These results suggest that down-regulation of the normal BER gap-filling DNA polymerase, pol beta, accompanies induced SHM in BL2 cells. This is consistent with the hypothesis that normal error-free BER must be silenced to make way for an error-prone BER process that may be required during somatic hypermutation. JF - DNA repair AU - Poltoratsky, Vladimir AU - Prasad, Rajendra AU - Horton, Julie K AU - Wilson, Samuel H AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, PO Box 12233, MD B2-06, Research Triangle Park, NC 27709, USA. Y1 - 2007/02/04/ PY - 2007 DA - 2007 Feb 04 SP - 244 EP - 253 VL - 6 IS - 2 SN - 1568-7864, 1568-7864 KW - Immunoglobulin Variable Region KW - 0 KW - Oligodeoxyribonucleotides KW - Recombinant Proteins KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Index Medicus KW - Immunoglobulin Variable Region -- genetics KW - DNA Repair KW - Humans KW - Oligodeoxyribonucleotides -- genetics KW - Recombinant Proteins -- genetics KW - Mutagenesis KW - Base Sequence KW - Down-Regulation KW - Recombinant Proteins -- metabolism KW - Adult KW - In Vitro Techniques KW - Substrate Specificity KW - Oligodeoxyribonucleotides -- metabolism KW - Palatine Tonsil -- enzymology KW - Immunohistochemistry KW - Cell Line KW - Male KW - Somatic Hypermutation, Immunoglobulin KW - DNA Polymerase beta -- genetics KW - DNA Polymerase beta -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68426730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Down-regulation+of+DNA+polymerase+beta+accompanies+somatic+hypermutation+in+human+BL2+cell+lines.&rft.au=Poltoratsky%2C+Vladimir%3BPrasad%2C+Rajendra%3BHorton%2C+Julie+K%3BWilson%2C+Samuel+H&rft.aulast=Poltoratsky&rft.aufirst=Vladimir&rft.date=2007-02-04&rft.volume=6&rft.issue=2&rft.spage=244&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-28 N1 - Date created - 2007-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2000 Jul 1;14(13):1642-50 [10887158] Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):1166-71 [10655502] Cell. 2000 Sep 1;102(5):553-63 [11007474] J Exp Med. 2000 Nov 20;192(10):F27-30 [11085756] Science. 2001 Mar 16;291(5511):2156-9 [11251121] Nat Immunol. 2001 Jun;2(6):537-41 [11376341] Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7976-81 [11427727] J Biol Chem. 2001 Sep 14;276(37):34659-63 [11457865] Chromosoma. 2001 Nov;110(6):402-10 [11734998] J Biol Chem. 2002 Apr 12;277(15):13184-91 [11821417] Proc Natl Acad Sci U S A. 2002 May 14;99(10):6860-5 [11983862] Nature. 2002 Jul 4;418(6893):99-103 [12097915] Nat Immunol. 2002 Sep;3(9):815-21 [12145648] Curr Biol. 2002 Oct 15;12(20):1748-55 [12401169] Nature. 2002 Oct 31;419(6910):944-7 [12410315] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] DNA Repair (Amst). 2003 May 13;2(5):609-22 [12713817] Cold Spring Harb Symp Quant Biol. 2000;65:143-55 [12760029] J Biol Chem. 2003 Jul 11;278(28):25947-51 [12734201] Nat Immunol. 2003 Oct;4(10):1023-8 [12958596] Cancer Res. 2004 Mar 15;64(6):1924-31 [15026325] Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4262-7 [14999097] Nature. 1970 Dec 12;228(5276):1045-7 [5483159] Nucleic Acids Res. 1977 Aug;4(8):2917-29 [909796] Cell Differ. 1978 Oct;7(5):237-48 [699053] Nature. 1993 Apr 22;362(6422):709-15 [8469282] J Biol Chem. 1995 Jan 13;270(2):949-57 [7822335] J Biol Chem. 1995 Jul 7;270(27):16402-8 [7608211] Science. 1995 Aug 4;269(5224):699-702 [7624801] Nature. 1996 Jan 11;379(6561):183-6 [8538772] J Biol Chem. 1996 Jul 26;271(30):17811-5 [8663612] Immunity. 1997 Jan;6(1):35-46 [9052835] J Biol Chem. 1998 Jan 9;273(2):898-902 [9422747] Mutat Res. 1999 Mar;436(2):157-78 [10095138] J Biol Chem. 2005 Sep 9;280(36):31641-7 [16002405] DNA Repair (Amst). 2005 Sep 28;4(10):1182-8 [15950550] Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13986-91 [16172387] EMBO J. 2005 Nov 2;24(21):3757-69 [16222339] Curr Opin Immunol. 2006 Apr;18(2):164-74 [16464563] J Immunol. 2000 Feb 1;164(3):1306-13 [10640744] Nature. 2000 Aug 31;406(6799):1015-9 [10984059] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison AN - 19988837; 7422936 AB - Background Although the use of magnetic resonance imaging (MRI) for the diagnosis of acute stroke is increasing, this method has not proved more effective than computed tomography (CT) in the emergency setting. We aimed to prospecnvely compare CT and MRI for emergency diagnosis of acute stroke. Methods We did a single-centre, prospective, blind comparison of non-contrast CT and MRI (with diffusion-weighted and susceptibility weighted images) in a consecutive series of patients referred for emergency assessment of suspected acute stroke. Scans were independently interpreted by four experts, who were unaware of clinical information, MRI-CT pairings, and follow-up imaging. Results 356 patients, 217 of whom had a final clinical diagnosis of acute stroke, were assessed. MRI detected acute stroke (ischaemic or haemorrhagic), acute ischaemic stroke, and chronic haemorrhage more frequently than did CT (p<0.0001, for all comparisons). MRI was similar to CT for the detection of acute intracranial haemorrhage. MRI detected acute ischaemic stroke in 164 of 356 patients (46%; 95% CI 41-51%), compared with CT in 35 of 356 patients (10%; 7-14%). In the subset of patients scanned within 3 h of symptom onset, MRI detected acute ischaemic stroke in 41 of 90 patients (46%; 35-56%); CT in 6 of 90 (7%; 3-14%). Relative to the final clinical diagnosis, MRI had a sensitivity of 83% (181 of 217; 78-88%) and CT of 26% (56 of 217; 20-32%) for the diagnosis of any acute stroke. Interpretation MRI is better than CT for detection of acute ischaemia, and can detect acute and chronic haemorrhage; therefore it should be the preferred test for accurate diagnosis of patients with suspected acute stroke. Because our patient sample encompassed the range of disease that is likely to be encountered in emergency cases of suspected stroke, our results are directly applicable to clinical practice. JF - Lancet AU - Chalela, JA AU - Kidwell, C S AU - Nentwich, L M AU - Luby, M AU - Butman, JA AU - Demchuk, A M AU - Hill, MD AU - Patronas, N AU - Latour, L AU - Warach, S AD - Section on Stroke Diagnostics and Therapeutics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Rm B1D733, MSC 1063 Bethesda, MD 20892, USA, warachs@ninds.nih.gov Y1 - 2007/02/02/ PY - 2007 DA - 2007 Feb 02 SP - 293 EP - 298 VL - 369 IS - 9558 SN - 0099-5355, 0099-5355 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Stroke KW - Magnetic resonance imaging KW - Computed tomography KW - Ischemia KW - Hemorrhage KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19988837?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Magnetic+resonance+imaging+and+computed+tomography+in+emergency+assessment+of+patients+with+suspected+acute+stroke%3A+a+prospective+comparison&rft.au=Chalela%2C+JA%3BKidwell%2C+C+S%3BNentwich%2C+L+M%3BLuby%2C+M%3BButman%2C+JA%3BDemchuk%2C+A+M%3BHill%2C+MD%3BPatronas%2C+N%3BLatour%2C+L%3BWarach%2C+S&rft.aulast=Chalela&rft.aufirst=JA&rft.date=2007-02-02&rft.volume=369&rft.issue=9558&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Lancet&rft.issn=00995355&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Computed tomography; Magnetic resonance imaging; Stroke; Ischemia; Hemorrhage ER - TY - JOUR T1 - Energy Policy Act of 2005 AN - 746200303; 11366631 AB - This article provides a comprehensive review and describes the impact of the bill on distributed generation, the electricity market, the national electrical grid, and the future of how electricity will be delivered in the United States. The energy policy act of 2005 removes the requirement that utilities purchase power under the condition that the qualifying facility has access to alternative markets. A single IEEE 1547 standard could be applied to any distributed resource interconnection. JF - IEEE Industry Applications Magazine AU - Malmedal, K AU - Kroposki, B AU - Sen, P K AD - NEI Electr. Power Eng., Arvada, CO Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 14 EP - 20 PB - Institute of Electrical and Electronics Engineers, Inc., 3 Park Avenue, 17th Fl New York NY 10016-5997 USA VL - 13 IS - 1 SN - 1077-2618, 1077-2618 KW - Sustainability Science Abstracts KW - USA KW - energy policy KW - Reviews KW - Utilities KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/746200303?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IEEE+Industry+Applications+Magazine&rft.atitle=Energy+Policy+Act+of+2005&rft.au=Malmedal%2C+K%3BKroposki%2C+B%3BSen%2C+P+K&rft.aulast=Malmedal&rft.aufirst=K&rft.date=2007-02-01&rft.volume=13&rft.issue=1&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=IEEE+Industry+Applications+Magazine&rft.issn=10772618&rft_id=info:doi/10.1109%2FMIA.2007.265799 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-05-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - energy policy; Reviews; Utilities; USA DO - http://dx.doi.org/10.1109/MIA.2007.265799 ER - TY - JOUR T1 - Invited comment: "Identification of a sensitive period for developmental programming that increases risk for uterine leiomyoma in Eker rats". AN - 70764615; 17636221 JF - Reproductive sciences (Thousand Oaks, Calif.) AU - Segars, James H AD - Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. segarsj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 99 EP - 100 VL - 14 IS - 2 KW - Estrogens, Non-Steroidal KW - 0 KW - Tumor Suppressor Proteins KW - tuberous sclerosis complex 2 protein KW - 4JG2LF96VF KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Rats KW - Animals KW - Rats, Mutant Strains KW - Humans KW - Tumor Suppressor Proteins -- genetics KW - Mutation KW - Gene Expression Regulation, Developmental -- drug effects KW - Female KW - Uterine Neoplasms -- chemically induced KW - Diethylstilbestrol -- toxicity KW - Estrogens, Non-Steroidal -- toxicity KW - Leiomyoma -- chemically induced KW - Uterus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70764615?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Improved+Antibacterial+Host+Defense+and+Altered+Peripheral+Granulocyte+Homeostasis+in+Mice+Lacking+the+Adhesion+Class+G+Protein+Receptor+CD97&rft.au=Wang%2C+Tao%3BTian%2C+Linhua%3BHaino%2C+Makoto%3BGao%2C+Ji-Liang%3BLake%2C+Ross%3BWard%2C+Yvona%3BWang%2C+Hongshan%3BSiebenlist%2C+Ulrich%3BMurphy%2C+Philip+M%3BKelly%2C+Kathleen&rft.aulast=Wang&rft.aufirst=Tao&rft.date=2007-03-01&rft.volume=75&rft.issue=3&rft.spage=1144&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Reprod Sci. 2007 Feb;14(2):121-36 [17636224] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dosimetry in myeloablative (90)Y-labeled ibritumomab tiuxetan therapy: possibility of increasing administered activity on the base of biological effective dose evaluation. Preliminary results. AN - 70707894; 17627419 AB - In our multicentric ongoing phase I activity escalation study, (90)Y-labeled ibritumomab tiuxetan (Ze-valin was administered in activity per kilo twice- and three times the maximum tolerable dose of 15 MBq/kg suggested for nonmyeloablative treatments by the U.S. registration study. The radioinduced myelodepression was overcome by stem cell autografting. The dosimetric aim was to correlate possible extramedullary toxicities to the organ-absorbed doses or to the biologic effective dose (BED). This is a conceptually more suitable parameter, as it takes into account not only the absorbed dose, but also the influence of the dose rate and of the tissue repair mechanism. Pretreatment planar dosimetry was performed on 16 patients with a median 200 MBq of (111)In-Zevalin. Conjugate view technique, background, attenuation, and partial scatter correction were adopted. Blood samples and a planar whole body scintigram were collected at least at 0.5, 48, 96, and 120 hours. Individual organ mass correction was based on a computed tomography scan. Internal dose calculation was performed by the OLINDA/EXM software. One (1) week after dosimetry, 12 patients were treated with 30 MBq/kg and 4 patients with 45 MBq/kg of (90)Y-Zevalin. The absorbed dose per unit activity (Gy/GBq) were (median and range of 16 dosimetric studies): heart wall 3.8 [0.5, 9.7]; kidneys 4.9 [2.8, 10.5]; liver 5.5 [3.9, 8.9]; lungs 2.8 [0.4, 6.8]; red marrow 1.1 [0.8, 2.1]; spleen 6.3 [1.5, 10.9]; and testes 4.6 [3.0, 16.7]. The absorbed dose (Gy) for the 4 patients administered with 45 MBq/kg were (median and range): heart wall 17.6 [9.4, 25.1]; kidneys 16.3 [7.9, 20.3]; liver 20.9 [15.4, 24.3]; lungs 7.7 [5.6, 11.4]; red marrow 3.0 [2.4, 3.3]; spleen 28.4 [18.9, 30.8]; and testes 16.5 [12.2, 17.3]. No extramedullary toxicity was observed. The administration of 45 MBq/kg of (90)Y ibritumomab tiuxetan to 4 patients with stem cell autografting was free from extramedullary toxicity. This is in agreement with both organ doses and BEDs below the corresponding toxicity thresholds. For these clinical and dosimetric reasons, a further increase in injectable activity could have been conceivable. If the more appropriate BED parameter were chosen for toxicity limit calculations, a wider margin of increase would have been possible. Our theoretical investigation demonstrates that, in this particular case of (90)Y Zevalin therapy, the uncertainty about radiobiological parameters was not a limiting factor for a BED-based calculation of the maximum injectable activity. JF - Cancer biotherapy & radiopharmaceuticals AU - Chiesa, Carlo AU - Botta, Francesca AU - Di Betta, Erika AU - Coliva, Angela AU - Maccauro, Marco AU - Aliberti, Gianluca AU - Bavusi, Sergio AU - Devizzi, Liliana AU - Guidetti, Anna AU - Seregni, Ettore AU - Gianni, Alessandro Massimo AU - Bombardieri, Emilio AD - Nuclear Medicine, National Cancer Institute, Milan, Italy. carlo.chiesa@istitutotumori.mi.it Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 113 EP - 120 VL - 22 IS - 1 SN - 1084-9785, 1084-9785 KW - Antibodies, Monoclonal KW - 0 KW - Myeloablative Agonists KW - Yttrium Radioisotopes KW - ibritumomab tiuxetan KW - 4Q52C550XK KW - Index Medicus KW - Radioimmunotherapy KW - Humans KW - Dose-Response Relationship, Radiation KW - Myeloablative Agonists -- immunology KW - Lymphoma, Non-Hodgkin -- therapy KW - Myeloablative Agonists -- therapeutic use KW - Antibodies, Monoclonal -- adverse effects KW - Myeloablative Agonists -- adverse effects KW - Myeloablative Agonists -- administration & dosage KW - Lymphoma, Non-Hodgkin -- immunology KW - Lymphoma, Non-Hodgkin -- pathology KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- therapeutic use KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70707894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biotherapy+%26+radiopharmaceuticals&rft.atitle=Dosimetry+in+myeloablative+%2890%29Y-labeled+ibritumomab+tiuxetan+therapy%3A+possibility+of+increasing+administered+activity+on+the+base+of+biological+effective+dose+evaluation.+Preliminary+results.&rft.au=Chiesa%2C+Carlo%3BBotta%2C+Francesca%3BDi+Betta%2C+Erika%3BColiva%2C+Angela%3BMaccauro%2C+Marco%3BAliberti%2C+Gianluca%3BBavusi%2C+Sergio%3BDevizzi%2C+Liliana%3BGuidetti%2C+Anna%3BSeregni%2C+Ettore%3BGianni%2C+Alessandro+Massimo%3BBombardieri%2C+Emilio&rft.aulast=Chiesa&rft.aufirst=Carlo&rft.date=2007-02-01&rft.volume=22&rft.issue=1&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Cancer+biotherapy+%26+radiopharmaceuticals&rft.issn=10849785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-20 N1 - Date created - 2007-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of the mitochondria in mediating cytotoxicity of anti-cancer therapies. AN - 70568567; 17294132 AB - Optimal cytotoxic anticancer therapy, at the cellular level, requires effective and selective induction of cell death to achieve a net reduction of biomass of malignant tissues. Standard cytotoxic chemotherapeutics have been developed based on the observations that mitotically active cancer cells are more susceptible than quiescent normal cells to chromosomal, microtubular or metabolic poisons. More recent development of molecularly targeted drugs for cancer focuses on exploiting biological differentials between normal and transformed cells for selective eradication of cancers. The common thread of "standard" and "novel" cytotoxic drugs is their ability to activate the apoptosis-inducing machinery mediated by mitochondria, also known as the intrinsic death signaling cascade. The aim of this article is to provide an overview of the role of the mitochondria, an energy-generating organelle essential for life, in mediating death when properly activated by cytotoxic stresses. JF - Journal of bioenergetics and biomembranes AU - Nguyen, Dao M AU - Hussain, Mustafa AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Room 4W-4-3940, 10 Center Drive, Bethesda, MD 29892, USA. dao_nguyen@nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 13 EP - 21 VL - 39 IS - 1 SN - 0145-479X, 0145-479X KW - Antineoplastic Agents KW - 0 KW - TNF-Related Apoptosis-Inducing Ligand KW - Index Medicus KW - Animals KW - Humans KW - TNF-Related Apoptosis-Inducing Ligand -- metabolism KW - Cell Death -- drug effects KW - Neoplasms -- drug therapy KW - Mitochondria -- physiology KW - Apoptosis -- physiology KW - Signal Transduction -- drug effects KW - Mitochondria -- drug effects KW - Apoptosis -- drug effects KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70568567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bioenergetics+and+biomembranes&rft.atitle=The+role+of+the+mitochondria+in+mediating+cytotoxicity+of+anti-cancer+therapies.&rft.au=Nguyen%2C+Dao+M%3BHussain%2C+Mustafa&rft.aulast=Nguyen&rft.aufirst=Dao&rft.date=2007-02-01&rft.volume=39&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Journal+of+bioenergetics+and+biomembranes&rft.issn=0145479X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-01 N1 - Date created - 2007-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study. AN - 70521342; 17510079 AB - The N-acetyltransferase 2 (NAT2) enzyme detoxifies aromatic amines, an important class of carcinogens in tobacco smoke. Slow acetylation phenotype individuals have reduced detoxification capacity compared with those with a rapid/intermediate phenotype. Analysis of the Spanish Bladder Cancer Study found an odds ratio (OR) for slow acetylators relative to rapid/intermediate acetylators of 0.9 in never-smokers and 1.6 in ever-smokers, a 1.8-fold enhancement in smokers. Evidence indicates that acetylation is an exposure-dependent process, and thus the magnitude of the interaction may also depend on exposure level. We extend a comprehensive three-parameter linear-exponential model for the excess odds ratio (EOR) for smoking to include effects of NAT2 status, and reanalyse smoking and NAT2 status for the bladder cancer data. We show that variations in smoking risk with NAT2 status result from interactions with smoking intensity (cigarettes per day) and not total pack-years of exposure. In addition, the relative increase in smoking risk in NAT2 slo acetylators increases with smoking intensity. Analyses reveal an enhanced effect for smoking intensity and bladder cancer in NAT2 slow acetylators which increases with intensity. JF - International journal of epidemiology AU - Lubin, Jay H AU - Kogevinas, Manolis AU - Silverman, Debra AU - Malats, Núria AU - Garcia-Closas, Montserrat AU - Tardón, Adonina AU - Hein, David W AU - Garcia-Closas, Reina AU - Serra, Consol AU - Dosemeci, Mustafa AU - Carrato, Alfredo AU - Rothman, Nathaniel AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 236 EP - 241 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Tobacco Smoke Pollution KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Humans KW - Linear Models KW - Aged KW - Risk Assessment -- methods KW - Genotype KW - Phenotype KW - Acetylation KW - Aged, 80 and over KW - Adult KW - Tobacco Smoke Pollution -- adverse effects KW - Middle Aged KW - Spain -- epidemiology KW - Tobacco -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Smoking -- metabolism KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- metabolism KW - Smoking -- epidemiology KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70521342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Evidence+for+an+intensity-dependent+interaction+of+NAT2+acetylation+genotype+and+cigarette+smoking+in+the+Spanish+Bladder+Cancer+Study.&rft.au=Lubin%2C+Jay+H%3BKogevinas%2C+Manolis%3BSilverman%2C+Debra%3BMalats%2C+N%C3%BAria%3BGarcia-Closas%2C+Montserrat%3BTard%C3%B3n%2C+Adonina%3BHein%2C+David+W%3BGarcia-Closas%2C+Reina%3BSerra%2C+Consol%3BDosemeci%2C+Mustafa%3BCarrato%2C+Alfredo%3BRothman%2C+Nathaniel&rft.aulast=Lubin&rft.aufirst=Jay&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: From phenotype, to genotype, to gene-environment interaction and risk for complex diseases. AN - 70520279; 17510072 JF - International journal of epidemiology AU - Olden, Kenneth AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences/NIH, Research Triangle Park, NC 27705, USA. olden@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 18 EP - 20 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Genotype KW - Genetic Predisposition to Disease -- genetics KW - Polymorphism, Genetic -- genetics KW - Humans KW - Environmental Exposure -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- toxicity KW - Arylamine N-Acetyltransferase -- analysis KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70520279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+From+phenotype%2C+to+genotype%2C+to+gene-environment+interaction+and+risk+for+complex+diseases.&rft.au=Olden%2C+Kenneth&rft.aulast=Olden&rft.aufirst=Kenneth&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=18&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2007 Feb;36(1):11-8 [17353184] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned. AN - 70514563; 17510073 JF - International journal of epidemiology AU - Rothman, Nathaniel AU - Garcia-Closas, Montserrat AU - Hein, David W AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, Bethesda, MD 20892, USA. rothmann@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 23 EP - 28 VL - 36 IS - 1 SN - 0300-5771, 0300-5771 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Acetylation KW - Genetic Predisposition to Disease -- genetics KW - Humans KW - Environmental Exposure -- adverse effects KW - Urinary Bladder Neoplasms -- epidemiology KW - Urinary Bladder Neoplasms -- genetics KW - Urinary Bladder Neoplasms -- enzymology KW - Arylamine N-Acetyltransferase -- metabolism KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70514563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Commentary%3A+Reflections+on+G.+M.+Lower+and+colleagues%27+1979+study+associating+slow+acetylator+phenotype+with+urinary+bladder+cancer%3A+meta-analysis%2C+historical+refinements+of+the+hypothesis%2C+and+lessons+learned.&rft.au=Rothman%2C+Nathaniel%3BGarcia-Closas%2C+Montserrat%3BHein%2C+David+W&rft.aulast=Rothman&rft.aufirst=Nathaniel&rft.date=2007-02-01&rft.volume=36&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-30 N1 - Date created - 2007-05-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Int J Epidemiol. 2007 Feb;36(1):11-8 [17353184] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Increased anxiety and other similarities in temperament of alcoholics with and without antisocial personality disorder across three diverse populations. AN - 70418461; 17452294 AB - According to Cloninger's model, type I alcoholics are thought to be innately vulnerable to anxiety and depression. In contrast, type II alcoholics are thought to have increased likelihood of antisocial personality disorder (ASPD) and reduced anxiety. However, allostatic activations of stress, anxiety, and dysphoria may be a common thread in alcohol use disorders (AUDs). Our aim was to find commonalities and differences in temperament of alcoholics with and without ASPD in three diverse populations. By sib-sib comparisons, we also evaluated the extent to which the temperament traits were moderated by familial factors including inheritance. We compared harm avoidance (HA), novelty seeking (NS), and reward dependence (RD) in alcoholics with ASPD, alcoholics without ASPD, and controls. Correlations for each temperament dimension were evaluated in pairs of siblings concordant and discordant for AUD. Participants were derived from three independent populations: Finnish Caucasians (N=453, men=100%, including a sample of alcoholic criminals), a Plains American Indian community sample (N=378; men=42%), and a subset of the familial and predominantly Caucasian Collaborative Study on the Genetics of Alcoholism (COGA) sample (N=967, men=47%). In all the three populations, both alcoholics with and without ASPD were higher in HA than controls. The increase of HA among alcoholics as compared to controls ranged from 54% to 12%. In two populations (COGA and Finns), NS was highest in alcoholics with ASPD, intermediate in alcoholics without ASPD, and lowest in controls. HA levels were correlated in sib-pairs concordant (either affected or unaffected) for AUD but not in discordant pairs. In conclusions, despite cultural diversity and different modes of ascertainment we found a consistent pattern of elevated HA in all groups of alcoholics, including alcoholics with ASPD. Even in alcoholics with long-term exposure to the anxiogenic effects of repeated cycles of alcohol withdrawal, genetic and other familial influences seem to play a role in moderating anxiety. JF - Alcohol (Fayetteville, N.Y.) AU - Ducci, Francesca AU - Enoch, Mary-Anne AU - Funt, Samuel AU - Virkkunen, Matti AU - Albaugh, Bernard AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, 5625 Fishers Lane, Room 3S32, MSC 9412, Bethesda, MD 20892, USA. duccif@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 3 EP - 12 VL - 41 IS - 1 SN - 0741-8329, 0741-8329 KW - Index Medicus KW - Cross-Sectional Studies KW - Reward KW - Humans KW - Adult KW - Exploratory Behavior KW - Crime -- statistics & numerical data KW - Middle Aged KW - Genetic Predisposition to Disease KW - United States -- epidemiology KW - Finland -- epidemiology KW - Male KW - Female KW - Harm Reduction KW - Antisocial Personality Disorder -- ethnology KW - European Continental Ancestry Group -- psychology KW - Anxiety -- epidemiology KW - European Continental Ancestry Group -- statistics & numerical data KW - Indians, North American -- psychology KW - Anxiety -- ethnology KW - Antisocial Personality Disorder -- psychology KW - Indians, North American -- statistics & numerical data KW - Alcoholism -- genetics KW - Alcoholism -- psychology KW - Alcohol-Induced Disorders -- epidemiology KW - Antisocial Personality Disorder -- epidemiology KW - Alcoholism -- epidemiology KW - Anxiety -- genetics KW - Alcohol-Induced Disorders -- genetics KW - Alcoholism -- ethnology KW - Temperament KW - Antisocial Personality Disorder -- genetics KW - Alcohol-Induced Disorders -- psychology KW - Anxiety -- etiology KW - Alcohol-Induced Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70418461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.atitle=Increased+anxiety+and+other+similarities+in+temperament+of+alcoholics+with+and+without+antisocial+personality+disorder+across+three+diverse+populations.&rft.au=Ducci%2C+Francesca%3BEnoch%2C+Mary-Anne%3BFunt%2C+Samuel%3BVirkkunen%2C+Matti%3BAlbaugh%2C+Bernard%3BGoldman%2C+David&rft.aulast=Ducci&rft.aufirst=Francesca&rft.date=2007-02-01&rft.volume=41&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Alcohol+%28Fayetteville%2C+N.Y.%29&rft.issn=07418329&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2007-04-24 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Gen Psychiatry. 2000 Aug;57(8):803-11 [10920470] Am J Med Genet B Neuropsychiatr Genet. 2006 Sep 5;141B(6):599-607 [16874763] J Consult Clin Psychol. 2000 Oct;68(5):818-29 [11068968] Aust N Z J Psychiatry. 2002 Feb;36(1):44-52 [11929437] J Nerv Ment Dis. 2002 Apr;190(4):225-32 [11960083] J Abnorm Psychol. 2002 Aug;111(3):411-24 [12150417] Mol Psychiatry. 2002;7(9):948-53 [12399947] Arch Gen Psychiatry. 2002 Dec;59(12):1125-32 [12470129] Psychiatry Res. 2003 Feb 15;117(2):159-66 [12606017] Arch Gen Psychiatry. 2003 Sep;60(9):929-37 [12963675] Psychol Med. 2003 Oct;33(7):1211-22 [14580076] Psychol Assess. 2003 Sep;15(3):360-9 [14593836] Arch Gen Psychiatry. 2004 Apr;61(4):361-8 [15066894] J Clin Child Adolesc Psychol. 2004 Sep;33(3):547-56 [15271612] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Pers Disord. 2004 Aug;18(4):379-93 [15342324] Arch Gen Psychiatry. 1978 Jul;35(7):837-44 [678037] Arch Gen Psychiatry. 1981 Aug;38(8):861-8 [7259422] Arch Gen Psychiatry. 1987 Jun;44(6):573-88 [3579504] Nebr Symp Motiv. 1986;34:27-83 [3498124] Arch Gen Psychiatry. 1992 Aug;49(8):599-608 [1637250] Arch Gen Psychiatry. 1993 Sep;50(9):690-8 [8357294] J Pers Soc Psychol. 1994 Apr;66(4):762-75 [8189351] J Stud Alcohol. 1994 Mar;55(2):149-58 [8189735] Eur Arch Psychiatry Clin Neurosci. 1995;245(4-5):239-44 [7578287] J Pers Soc Psychol. 1996 Jan;70(1):127-40 [8558406] J Stud Alcohol. 1997 Jan;58(1):48-66 [8979213] J Stud Alcohol. 1997 Mar;58(2):167-81 [9065895] Arch Gen Psychiatry. 1997 Apr;54(4):313-21 [9107147] Alcohol Clin Exp Res. 1997 May;21(3):513-20 [9161612] Addiction. 1997 Oct;92(10):1289-304 [9489046] Arch Gen Psychiatry. 1998 Nov;55(11):989-94 [9819067] Addiction. 2004 Dec;99(12):1508-19 [15585042] Alcohol Health Res World. 1997;21(2):101-6 [15704343] Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):48-55 [15704214] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] JAMA. 2005 Aug 3;294(5):616-8 [16077057] Behav Genet. 2005 Nov;35(6):707-21 [16273321] Alcohol Clin Exp Res. 2006 Mar;30(3):399-406 [16499480] Am J Med Genet. 2000 Oct 9;96(5):684-95 [11054778] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neonatal dopamine depletion induces changes in morphogenesis and gene expression in the developing cortex. AN - 70404521; 17449454 AB - The mesocorticolimbic dopamine (DA) system is implicated in mental health disorders affecting attention, impulse inhibition and other cognitive functions. It has also been involved in the regulation of cortical morphogenesis. The present study uses focal injections of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle of BALB/c mice to examine morphological, behavioral and transcriptional responses to selective DA deficit in the fronto-parietal cortex. Mice that received injections of 6-OHDA on postnatal day 1 (PND1) showed reduction in DA levels in their cortices at PND7. Histological analysis at PND120 revealed increased fronto-cortical width, but decreased width of somatosensory parietal cortex. Open field object recognition suggested impaired response inhibition in adult mice after 6-OHDA treatment. Transcriptional analyses using 17K mouse microarrays showed that such lesions caused up-regulation of 100 genes in the cortex at PND7. Notably, among these genes are Sema3A which plays a repulsive role in axonal guidance, RhoD which inhibits dendritic growth and tubulin beta-5 microtubule subunit. In contrast, 127 genes were down-regulated, including CCT-epsilon and CCT-zeta that play roles in actin and tubulin folding. Thus, neonatal DA depletion affects transcripts involved in control of cytoskeletal formation and pathway finding, instrumental for normal differentiation and synaptogenesis. The observed gene expression changes are consistent with histological cortical and behavioral impairments in the adult mice treated with 6-OHDA on PND1. Our results point towards specific molecular targets that might be involved in disease process mediated by altered developmental DA regulation. JF - Neurotoxicity research AU - Krasnova, Irina N AU - Betts, Elizabeth S AU - Dada, Abiola AU - Jefferson, Akilah AU - Ladenheim, Bruce AU - Becker, Kevin G AU - Cadet, Jean Lud AU - Hohmann, Christine F AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institutes of Health/DHHS, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 107 EP - 130 VL - 11 IS - 2 SN - 1029-8428, 1029-8428 KW - Sympatholytics KW - 0 KW - Oxidopamine KW - 8HW4YBZ748 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Denervation KW - Mice, Inbred BALB C KW - Sympatholytics -- toxicity KW - Animals, Newborn KW - Corpus Striatum -- physiology KW - Oxidopamine -- toxicity KW - Corpus Striatum -- growth & development KW - Motor Activity KW - Reflex KW - Female KW - Male KW - Gene Expression Regulation, Developmental -- physiology KW - Prosencephalon -- growth & development KW - Oligonucleotide Array Sequence Analysis KW - Dopamine -- deficiency KW - Dopamine -- metabolism KW - Prosencephalon -- physiology KW - Gene Expression Regulation, Developmental -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70404521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicity+research&rft.atitle=Neonatal+dopamine+depletion+induces+changes+in+morphogenesis+and+gene+expression+in+the+developing+cortex.&rft.au=Krasnova%2C+Irina+N%3BBetts%2C+Elizabeth+S%3BDada%2C+Abiola%3BJefferson%2C+Akilah%3BLadenheim%2C+Bruce%3BBecker%2C+Kevin+G%3BCadet%2C+Jean+Lud%3BHohmann%2C+Christine+F&rft.aulast=Krasnova&rft.aufirst=Irina&rft.date=2007-02-01&rft.volume=11&rft.issue=2&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Neurotoxicity+research&rft.issn=10298428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-23 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Image-guided convection-enhanced delivery of gemcitabine to the brainstem. AN - 70353517; 17410722 AB - To determine if the potent antiglioma chemotherapeutic agent gemcitabine could be delivered to the brainstem safely at therapeutic doses while monitoring its distribution using a surrogate magnetic resonance (MR) imaging tracer, the authors used convection-enhanced delivery to perfuse the primate brainstem with gemcitabine and Gd-diethylenetriamine pentaacetic acid (DTPA). Six primates underwent convective brainstem perfusion with gemcitabine (0.4 mg/ml; two animals), Gd-DTPA (5 mM; two animals), or a coinfusion of gemcitabine (0.4 mg/ml) and Gd-DTPA (5 mM; two animals), and were killed 28 days afterward. These primates were observed over time clinically (six animals), and with MR imaging (five animals), quantitative autoradiography (one animal), and histological analysis (all animals). In an additional primate, 3H-gemcitabine and Gd-DTPA were coinfused and the animal was killed immediately afterward. In the primates there was no histological evidence of infusate-related tissue toxicity. Magnetic resonance images obtained during infusate delivery demonstrated that the anatomical region infused with Gd-DTPA was clearly distinguishable from surrounding noninfused tissue. Quantitative autoradiography confirmed that Gd-DTPA tracked the distribution of 3H-gemcitabine and closely approximated its volume of distribution (mean volume of distribution difference 13.5%). Conclusions. Gemcitabine can be delivered safely and effectively to the primate brainstem at therapeutic concentrations and at volumes that are higher than those considered clinically relevant. Moreover, MR imaging can be used to track the distribution of gemcitabine by adding Gd-DTPA to the infusate. This delivery paradigm should allow for direct therapeutic application of gemcitabine to brainstem gliomas while monitoring its distribution to ensure effective tumor coverage and to maximize safety. JF - Journal of neurosurgery AU - Murad, Gregory J A AU - Walbridge, Stuart AU - Morrison, Paul F AU - Szerlip, Nicholas AU - Butman, John A AU - Oldfield, Edward H AU - Lonser, Russell R AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 351 EP - 356 VL - 106 IS - 2 SN - 0022-3085, 0022-3085 KW - Antimetabolites, Antineoplastic KW - 0 KW - Contrast Media KW - Deoxycytidine KW - 0W860991D6 KW - gemcitabine KW - B76N6SBZ8R KW - Gadolinium DTPA KW - K2I13DR72L KW - Abridged Index Medicus KW - Index Medicus KW - Magnetic Resonance Imaging KW - Animals KW - Macaca mulatta KW - Convection KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Brain Stem -- metabolism KW - Infusions, Intralesional -- methods KW - Deoxycytidine -- pharmacokinetics KW - Deoxycytidine -- analogs & derivatives KW - Deoxycytidine -- administration & dosage KW - Antimetabolites, Antineoplastic -- pharmacokinetics KW - Therapy, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70353517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurosurgery&rft.atitle=Image-guided+convection-enhanced+delivery+of+gemcitabine+to+the+brainstem.&rft.au=Murad%2C+Gregory+J+A%3BWalbridge%2C+Stuart%3BMorrison%2C+Paul+F%3BSzerlip%2C+Nicholas%3BButman%2C+John+A%3BOldfield%2C+Edward+H%3BLonser%2C+Russell+R&rft.aulast=Murad&rft.aufirst=Gregory+J&rft.date=2007-02-01&rft.volume=106&rft.issue=2&rft.spage=351&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurosurgery&rft.issn=00223085&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-04-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dust weight and asthma prevalence in the National Survey of Lead and Allergens in Housing (NSLAH). AN - 70304909; 17384767 AB - Settled dust has been used in studies to assess exposures to allergens and other biologically active components, but it has not been considered in the aggregate in relation to respiratory health outcomes in the general population. We addressed whether total house dust weight, an index of total dust exposure, was associated with respiratory health outcomes in the National Survey of Lead and Allergens in Housing (1998-1999) (NSLAH). NSLAH was a cross-sectional survey designed to represent permanently occupied housing units in the United States. In each household, a questionnaire was administered and settled dust was vacuumed from five locations. Linear regression models were used to identify predictors of dust weight; logistic regression models were used to examine the relationship between dust weight and asthma and wheeze. Dust weight samples were available for 829 households, and survey information was available for 2,456 participants (children and adults). Lower income, older homes, household pets, having a smoker in the house, and less frequent cleaning predicted higher dust weight levels in U.S. households. Higher levels of dust weight were associated with greater odds of current asthma and wheeze. The strongest associations were seen for wheeze [adjusted odds ratio (OR) = 1.99; 95% confidence interval (CI), 1.21-3.28 for bedroom bed dust; OR = 2.81; 95% CI, 1.52-5.21 for upholstery dust). These associations persisted when adjusting for allergen and endotoxin exposures. Dust weight, an index of total dust exposure in the home, may contribute to respiratory outcomes independently of the exposure to specific components. JF - Environmental health perspectives AU - Elliott, Leslie AU - Arbes, Samuel J AU - Harvey, Eric S AU - Lee, Robert C AU - Salo, Päivi M AU - Cohn, Richard D AU - London, Stephanie J AU - Zeldin, Darryl C AD - Laboratory of Respiratory Biology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 215 EP - 220 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - Allergens KW - 0 KW - Dust KW - Lead KW - 2P299V784P KW - Index Medicus KW - United States KW - Environmental Monitoring KW - Regression Analysis KW - Cross-Sectional Studies KW - Particle Size KW - Humans KW - Health Surveys KW - Environmental Exposure KW - Epidemiological Monitoring KW - Lead -- analysis KW - Asthma -- epidemiology KW - Air Pollution, Indoor -- analysis KW - Housing KW - Dust -- analysis KW - Allergens -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70304909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Dust+weight+and+asthma+prevalence+in+the+National+Survey+of+Lead+and+Allergens+in+Housing+%28NSLAH%29.&rft.au=Elliott%2C+Leslie%3BArbes%2C+Samuel+J%3BHarvey%2C+Eric+S%3BLee%2C+Robert+C%3BSalo%2C+P%C3%A4ivi+M%3BCohn%2C+Richard+D%3BLondon%2C+Stephanie+J%3BZeldin%2C+Darryl+C&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=215&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Respir Crit Care Med. 2005 Dec 1;172(11):1371-7 [16141442] Environ Health Perspect. 2005 Oct;113(10):1430-6 [16203259] Thorax. 2000 May;55(5):424-31 [10770825] Environ Health Perspect. 2000 Aug;108 Suppl 4:705-12 [10931789] Lancet. 2000 Oct 21;356(9239):1392-7 [11052581] Pediatrics. 2001 Aug;108(2):E33 [11483843] Environ Health Perspect. 2002 May;110(5):527-32 [12003758] Rev Environ Contam Toxicol. 2002;175:1-46 [12206053] Environ Health Perspect. 2002 Oct;110(10):A599-606 [12361941] Environ Health Perspect. 2003 Jul;111(9):1265-72 [12842784] Occup Environ Med. 2003 Sep;60(9):E5 [12937201] Environ Health Perspect. 2004 Apr;112(5):571-4 [15064163] J Expo Anal Environ Epidemiol. 2004;14 Suppl 1:S34-40 [15118743] Environ Health Perspect. 2004 May;112(6):760-5 [15121522] J Expo Anal Environ Epidemiol. 2004 Sep;14(5):397-403 [15361899] Environ Health Perspect. 2004 Oct;112(14):1393-7 [15471731] J Allergy Clin Immunol. 2004 Oct;114(4):858-62 [15480327] Panminerva Med. 2004 Jun;46(2):97-110 [15507879] Int Arch Allergy Appl Immunol. 1966;30(4):368-81 [5927733] Ann Allergy. 1967 Oct;25(10):598-9 [6055710] Ann Allergy. 1969 Mar;27(3):93-9 [5773134] Can Med Assoc J. 1970 Aug 1;103(3):300-1 [4915743] JAMA. 1970 Sep 7;213(10):1687 [5468718] Ann Allergy. 1970 Nov;28(11):543-7 [5521185] Am J Public Health. 1989 Mar;79(3):340-9 [2916724] N Engl J Med. 1990 Aug 23;323(8):502-7 [2377175] Lancet. 1995 Jan 21;345(8943):176-8 [7741860] Clin Exp Allergy. 1995 Feb;25(2):114-8 [7750002] J Allergy Clin Immunol. 1995 Oct;96(4):441-8 [7560653] Rev Environ Contam Toxicol. 1995;143:59-78 [7501867] Int J Epidemiol. 1996 Jun;25(3):609-16 [8671563] Clin Exp Allergy. 1998 May;28(5):537-44 [9645589] Allergy. 1998 Nov;53(11):1060-5 [9860238] Thorax. 1999 Mar;54(3):268-72 [10325905] J Indian Med Assoc. 1958 Apr 1;30(7):216-9 [13549740] J Indian Med Assoc. 1965 Jun 1;44:607-9 [14343895] Allerg Asthma (Leipz). 1964;10:329-34 [14307280] Eur Respir J. 2005 Feb;25(2):303-8 [15684295] Indoor Air. 1999 Dec;9(4):219-25 [10649856] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells. AN - 70302628; 17384772 AB - Prostate cancer progression often occurs with overexpression of growth factors and receptors, many of which engage the Ras/mitogen-activated protein MAP kinase (MAPK) pathway. In this study we used arsenic-transformed human prostate epithelial cells, which also show androgen-independent growth, to study the possibility that chronic activation of Ras/MAPK signaling may contribute to arsenic-induced prostate cancer progression. Control and chronic arsenic-transformed prostate epithelial cells (CAsE-PE) were compared for Ras/MAPK signaling capacities using reverse transcription-polymerase chain reaction and Western blot analyses. We found activation of HER-2/neu oncogene in transformed CAsE-PE cells, providing molecular evidence of androgen independence in the transformed cells. CAsE-PE cells displayed constitutively increased expression of unmutated K-Ras (6-fold), and the downstream MAP kinases A-Raf and B-Raf (2.2-fold and 3.2-fold, respectively). There was also increased expression of phosphorylated MEK1/2 and Elk1 in the transformant cells. The MEK1/2 inhibitor, U0126, blocked PSA overexpression in CAsE-PE cells. Thus, arsenic-induced malignant transformation and acquired androgen independence are linked to Ras signaling activation in human prostate epithelial cells. Chronic activation of this pathway can sensitize the androgen receptor to subphysiologic levels of androgen. This may be important in arsenic carcinogenesis and provide a mechanism that may be common for prostate cancer progression driven by diverse agents. JF - Environmental health perspectives AU - Benbrahim-Tallaa, Lamia AU - Webber, Mukta M AU - Waalkes, Michael P AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 243 EP - 247 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - AR protein, human KW - 0 KW - Androgens KW - Environmental Pollutants KW - Receptors, Androgen KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - raf Kinases KW - EC 2.7.11.1 KW - Proto-Oncogene Proteins p21(ras) KW - EC 3.6.5.2 KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Proto-Oncogene Proteins p21(ras) -- metabolism KW - raf Kinases -- metabolism KW - Receptor, ErbB-2 -- metabolism KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Models, Biological KW - Epithelial Cells -- metabolism KW - Prostatic Neoplasms -- etiology KW - Blotting, Western KW - MAP Kinase Signaling System KW - Epithelial Cells -- drug effects KW - Cells, Cultured KW - Androgens -- physiology KW - Male KW - Prostate -- drug effects KW - Environmental Pollutants -- toxicity KW - Arsenic -- toxicity KW - Receptors, Androgen -- metabolism KW - Cell Transformation, Neoplastic -- chemically induced KW - Prostate -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70302628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Mechanisms+of+acquired+androgen+independence+during+arsenic-induced+malignant+transformation+of+human+prostate+epithelial+cells.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1997 Jun;18(6):1215-23 [9214605] J Cell Biochem. 2006 Oct 1;99(2):373-81 [16598769] Cancer Detect Prev. 1998;22(5):476-84 [9727630] Cancer Res. 1998 Dec 15;58(24):5718-24 [9865729] Cancer Res. 1999 Jan 15;59(2):279-84 [9927031] Nat Med. 1999 Mar;5(3):280-5 [10086382] Environ Health Perspect. 1999 May;107(5):359-65 [10210691] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5458-63 [10318905] Growth Factors. 2004 Sep;22(3):179-84 [15518241] Clin Cancer Res. 1999 Oct;5(10):2891-8 [10537358] Oral Oncol. 1999 Nov;35(6):561-3 [10705090] Endocr Relat Cancer. 1999 Dec;6(4):487-502 [10730903] Cancer Res. 2000 Dec 15;60(24):6841-5 [11156376] Cancer Res. 2001 Apr 1;61(7):2892-8 [11306464] Cancer Res. 2001 May 1;61(9):3550-5 [11325816] Nat Rev Cancer. 2001 Oct;1(1):34-45 [11900250] Endocr Relat Cancer. 2002 Mar;9(1):61-73 [11914183] J Natl Cancer Inst. 2002 Dec 18;94(24):1888-91 [12488483] Cancer Res. 2002 Dec 15;62(24):7154-6 [12499248] Cancer Res. 2003 Apr 15;63(8):1975-80 [12702591] Cancer Res. 2003 Apr 15;63(8):1981-9 [12702592] J Cell Biochem. 2004 Jan 1;91(1):13-25 [14689577] Urology. 2003 Dec 22;62(6 Suppl 1):3-12 [14706503] Br J Cancer. 2004 Jan 26;90(2):443-8 [14735191] Am J Epidemiol. 1989 Dec;130(6):1123-32 [2589305] Cancer Res. 1990 Sep 1;50(17):5470-4 [2386951] Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6319-23 [1631125] Mol Carcinog. 1992;5(4):320-7 [1353965] Lab Invest. 1993 Jan;68(1):33-44 [8423674] Int J Cancer. 1994 May 1;57(3):406-12 [8169003] Cancer Res. 1994 Oct 15;54(20):5474-8 [7522959] Mol Endocrinol. 1997 Apr;11(4):450-9 [9092797] J Cell Biochem. 2004 Feb 15;91(3):483-90 [14755679] J Cell Biochem. 2004 Mar 1;91(4):662-70 [14991758] Lancet Oncol. 2004 May;5(5):303-13 [15120667] Oncol Rep. 2004 Jun;11(6):1273-9 [15138566] Clin Cancer Res. 2004 Jul 15;10(14):4742-5 [15269147] J Cell Biochem. 2004 Oct 1;93(2):233-41 [15368351] Endocrinology. 1988 Feb;122(2):552-62 [2828003] Gynecol Oncol. 2004 Dec;95(3):570-5 [15581965] IARC Monogr Eval Carcinog Risks Hum. 2004;84:269-477 [15645578] Toxicol Appl Pharmacol. 2005 Aug 15;206(3):288-98 [16039940] Environ Health Perspect. 2005 Sep;113(9):1134-9 [16140617] Zhonghua Yi Xue Za Zhi. 2005 Jun 15;85(22):1530-4 [16179111] Mol Cancer Ther. 2005 Nov;4(11):1662-9 [16275987] Endocr Relat Cancer. 2005 Dec;12(4):805-22 [16322323] BJU Int. 2006 Jan;97(1):170-8 [16336351] Carcinogenesis. 1997 Jun;18(6):1225-31 [9214606] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inferring past pesticide exposures: a matrix of individual active ingredients in home and garden pesticides used in past decades. AN - 70302546; 17384773 AB - In retrospective studies of the health effects of home and garden pesticides, self-reported information typically forms the basis for exposure assessment. Study participants generally find it easier to remember the types of pests treated than the specific pesticides used. However, if the goal of the study is to assess disease risk from specific chemicals, the investigator must be able to link the pest type treated with specific chemicals or products. Our goal was to develop a "pesticide-exposure matrix" that would list active ingredients on the market for treating different types of pests in past years, and provide an estimate of the probability that each active ingredient was used. We used several different methods for deriving the active ingredient lists and estimating the probabilities. These methods are described in this article, along with a sample calculation and data sources for each. The pesticide-exposure matrix lists active ingredients and their probabilities of use for 96 distinct scenarios defined by year (1976, 1980, 1990, 2000), applicator type (consumer, professional), and pest type (12 categories). Calculations and data sources for all 96 scenarios are provided online. Although we are confident that the active ingredient lists are reasonably accurate for most scenarios, we acknowledge possible sources of error in the probability estimates. Despite these limitations, the pesticide-exposure matrix should provide valuable information to researchers interested in the chronic health effects of residential pesticide exposure. JF - Environmental health perspectives AU - Colt, Joanne S AU - Cyr, Mancer J AU - Zahm, Shelia H AU - Tobias, Geoffrey S AU - Hartge, Patricia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. coltj@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 248 EP - 254 VL - 115 IS - 2 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Index Medicus KW - Gardening KW - Probability KW - Pest Control KW - Humans KW - Retrospective Studies KW - Risk Assessment -- methods KW - Pesticides -- chemistry KW - Pesticides -- analysis KW - Pesticides -- classification KW - Environmental Exposure -- analysis KW - Environmental Exposure -- classification UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70302546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Inferring+past+pesticide+exposures%3A+a+matrix+of+individual+active+ingredients+in+home+and+garden+pesticides+used+in+past+decades.&rft.au=Colt%2C+Joanne+S%3BCyr%2C+Mancer+J%3BZahm%2C+Shelia+H%3BTobias%2C+Geoffrey+S%3BHartge%2C+Patricia&rft.aulast=Colt&rft.aufirst=Joanne&rft.date=2007-02-01&rft.volume=115&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2007-03-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2001 Jan;12(1):20-7 [11138814] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):373-80 [12198585] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):934-7 [15824166] Environ Health Perspect. 1997 Nov;105(11):1214-20 [9370522] J Expo Anal Environ Epidemiol. 1997 Apr-Jun;7(2):217-34 [9185013] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatic transcript levels for genes coding for enzymes associated with xenobiotic metabolism are altered with age. AN - 70278203; 17366318 AB - Metabolism studies are crucial for data interpretation from rodent toxicity and carcinogenicity studies. Metabolism studies are usually conducted in 6 to 8 week old rodents. Long-term studies often continue beyond 100 weeks of age. The potential for age-related changes in transcript levels of genes encoding for enzymes associated with metabolism was evaluated in the liver of male F344/N rats at 32, 58, and 84 weeks of age. Differential expression was found between the young and old rats for genes whose products are involved in both phase I and phase II metabolic pathways. Thirteen cytochrome P450 genes from CYP families 1-3 showed alterations in expression in the older rats. A marked age-related decrease in expression was found for 4 members of the Cyp3a family that are critical for drug metabolism in the rat. Immunohistochemical results confirmed a significant decrease in Cyp3a2 and Cyp2c11 protein levels with age. This indicates that the metabolic capacity of male rats changes throughout a long-term study. Conducting multiple hepatic microarray analyses during the conduct of a long-term study can provide a global view of potential metabolic changes that might occur. Alterations that are considered crucial to the interpretation of long-term study results could then be confirmed by subsequent metabolic studies. JF - Toxicologic pathology AU - Mori, Kazuhiko AU - Blackshear, Pamela E AU - Lobenhofer, Edward K AU - Parker, Joel S AU - Orzech, Denise P AU - Roycroft, Joseph H AU - Walker, Kimwa L AU - Johnson, Kennita A AU - Marsh, Tiwanda A AU - Irwin, Richard D AU - Boorman, Gary A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27701, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 242 EP - 251 VL - 35 IS - 2 SN - 0192-6233, 0192-6233 KW - Membrane Proteins KW - 0 KW - Xenobiotics KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2C11 protein, rat KW - Cyp3a2 protein, rat KW - Cytochrome P-450 CYP3A KW - Cytochrome P450 Family 2 KW - Steroid 16-alpha-Hydroxylase KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Age Factors KW - Gene Expression Regulation, Enzymologic KW - Reproducibility of Results KW - Oligonucleotide Array Sequence Analysis KW - Toxicity Tests KW - Male KW - Transcription, Genetic -- physiology KW - Aging -- metabolism KW - Liver -- enzymology KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Steroid 16-alpha-Hydroxylase -- genetics KW - Steroid 16-alpha-Hydroxylase -- metabolism KW - Xenobiotics -- metabolism KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- genetics KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70278203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Hepatic+transcript+levels+for+genes+coding+for+enzymes+associated+with+xenobiotic+metabolism+are+altered+with+age.&rft.au=Mori%2C+Kazuhiko%3BBlackshear%2C+Pamela+E%3BLobenhofer%2C+Edward+K%3BParker%2C+Joel+S%3BOrzech%2C+Denise+P%3BRoycroft%2C+Joseph+H%3BWalker%2C+Kimwa+L%3BJohnson%2C+Kennita+A%3BMarsh%2C+Tiwanda+A%3BIrwin%2C+Richard+D%3BBoorman%2C+Gary+A&rft.aulast=Mori&rft.aufirst=Kazuhiko&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=242&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - GSE4270; GEO N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression analysis offers unique advantages to histopathology in liver biopsy evaluations. AN - 70276342; 17366322 AB - Liver diseases that induce nonuniform lesions often give rise to greatly varying histopathology results in needle biopsy samples from the same patient. This study examines whether gene expression analysis of such biopsies could provide a more representative picture of the overall condition of the liver. We utilized acetaminophen (APAP) as a model hepatotoxicant that gives a multifocal pattern of necrosis following toxic doses. Rats were treated with a single toxic or subtoxic dose of APAP and sacrificed 6, 24, or 48 hours after exposure. Left liver lobes were harvested, and both gene expression and histopathological analysis were performed on biopsy-sized samples. While histopathological evaluation of such small samples revealed significant sample to sample differences after toxic doses of APAP, gene expression analysis provided a very homogeneous picture and allowed clear distinction between subtoxic and toxic doses. The main biological function differentiating animals that received sub-toxic from those that had received toxic doses was an acute stress response at 6 hours and signs of energy depletion at later time points. Our results suggest that the use of genomic analysis of biopsy samples together with histopathological analysis could provide a more precise representation of the overall condition of a patient's liver than histopathological evaluation alone. JF - Toxicologic pathology AU - Heinloth, Alexandra N AU - Boorman, Gary A AU - Foley, Julie F AU - Flagler, Norris D AU - Paules, Richard S AD - National Center for Toxicogenomics, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 276 EP - 283 VL - 35 IS - 2 SN - 0192-6233, 0192-6233 KW - Analgesics, Non-Narcotic KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Rats KW - Animals KW - Analgesics, Non-Narcotic -- adverse effects KW - Rats, Inbred F344 KW - Necrosis -- chemically induced KW - Dose-Response Relationship, Drug KW - Acetaminophen -- adverse effects KW - Cytochrome P-450 Enzyme System -- metabolism KW - Necrosis -- pathology KW - Biopsy KW - Necrosis -- metabolism KW - Male KW - Gene Expression Profiling KW - Liver -- pathology KW - Liver Diseases -- complications KW - Liver -- drug effects KW - Liver Diseases -- pathology KW - Liver -- metabolism KW - Liver Diseases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70276342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Gene+expression+analysis+offers+unique+advantages+to+histopathology+in+liver+biopsy+evaluations.&rft.au=Heinloth%2C+Alexandra+N%3BBoorman%2C+Gary+A%3BFoley%2C+Julie+F%3BFlagler%2C+Norris+D%3BPaules%2C+Richard+S&rft.aulast=Heinloth&rft.aufirst=Alexandra&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=276&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-01 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Toxicol Pathol. 2007;35(6):850 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoking and quitting behaviors among unemployed adults in the United States. AN - 70272913; 17365755 AB - Little is known about factors associated with smoking among the unemployed. This study estimated the prevalence of smoking and examined sociodemographic factors associated with current, former, and successful quitting among unemployed adults aged 18-64. Cross-sectional data on 13,480 participants in the 1998-1999 and 2001-2002 Tobacco Use Supplements to the Current Population Surveys were analyzed. Multivariate logistic regression analyses were used to examine factors associated with study outcomes (current vs. never, former vs. current, successful quitter vs. other former smoker). Among the unemployed, 35% were current smokers and 13% were former smokers. Of the former smokers, 81% quit successfully for at least 12 months. Participants with family incomes of less than US$25,000 were more likely than those with incomes of $50,000 or more to currently smoke (OR=2.13, 95% CI=1.85-2.46). Service workers and blue-collar workers were less likely than white-collar workers to report former smoking. Participants unemployed for 6 months or more were twice as likely as those unemployed for less than 6 months to quit successfully (OR=2.05, 95% CI=1.07-3.95). Unemployed blue-collar workers had a greater odds ratio of successfully quitting than white-collar workers (OR=1.83, 95% CI=1.17-2.87). Smoking rates were high among the unemployed, and quitting behaviors varied by sociodemographic factors and length of unemployment. Studies are needed to examine the feasibility of cessation interventions for the unemployed. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Fagan, Pebbles AU - Shavers, Vickie AU - Lawrence, Deirdre AU - Gibson, James Todd AU - Ponder, Paris AD - National Cancer Institute, Tobacco Control Research Branch, Behavioral Research Program, Division of Cancer Control and Population Sciences, Bethesda, MD 20892, USA. faganp@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 241 EP - 248 VL - 9 IS - 2 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Behavior KW - Humans KW - Adult KW - Middle Aged KW - Workplace KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Prevalence KW - Multivariate Analysis KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- psychology KW - Unemployment -- statistics & numerical data KW - Unemployment -- psychology KW - Smoking -- psychology KW - Smoking -- epidemiology KW - Smoking Cessation -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70272913?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Cigarette+smoking+and+quitting+behaviors+among+unemployed+adults+in+the+United+States.&rft.au=Fagan%2C+Pebbles%3BShavers%2C+Vickie%3BLawrence%2C+Deirdre%3BGibson%2C+James+Todd%3BPonder%2C+Paris&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-02-01&rft.volume=9&rft.issue=2&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-05 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Functional deficiency in IL-7 caused by an N-ethyl-N-nitrosourea-induced point mutation. AN - 70207183; 17179092 AB - N-ethyl-N-nitrosourea (ENU)-induced mutagenesis provides a powerful approach for identifying genes involved in immune regulation and diseases. Here we describe a new mutant strain, HLB368, with hereditary leukopenia. At necropsy, the mutant mice had very small thymuses and spleens. All but the inguinal nodes were absent and there were no Peyer's patches. By flow cytometry, the ratios of T-cell subsets were normal, but B-cell development was blocked at the pre-pro-B-cell stage. The development of B1 and marginal zone B cells was relatively normal. The mutation was mapped to chromosome 3 between D3Mit221 and D3Mit224, a region that contains the Il7 gene. cDNA and genomic DNA sequences of Il7 revealed a T-to-C missense transition resulting in a change of Leu to Pro within the leader peptide that would be predicted to inhibit secretion. In keeping with this concept, we found that in vitro treatment of B-cell progenitors from mutant mice with IL-7 induced them to differentiate into pre-BII cells. Phenotypic comparisons of HLB368 with genetically targeted Il7 null mice showed many similarities along with a few differences, indicating that this ENU-induced mutant carries a novel allele. This new strain thus provides a new model for studying the functions of IL-7 on a pure C57BL/6 background. JF - Genetics AU - Feng, Jianxun AU - Wang, Hongsheng AU - Morse, Herbert C AD - Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 545 EP - 551 VL - 175 IS - 2 SN - 0016-6731, 0016-6731 KW - Interleukin-7 KW - 0 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - T-Lymphocyte Subsets -- cytology KW - Thymus Gland -- cytology KW - Animals KW - B-Lymphocytes -- cytology KW - Cell Count KW - Spleen -- cytology KW - Mice KW - Chromosome Mapping KW - Thymus Gland -- drug effects KW - Lymphoid Tissue -- abnormalities KW - Phenotype KW - Lymphocyte Activation -- drug effects KW - B-Lymphocytes -- drug effects KW - Mice, Mutant Strains KW - Base Sequence KW - Lymphocyte Activation -- immunology KW - Myeloid Cells -- cytology KW - Molecular Sequence Data KW - Flow Cytometry KW - Bone Marrow Cells -- cytology KW - Spleen -- drug effects KW - Myeloid Cells -- drug effects KW - Cell Differentiation -- drug effects KW - Lymphoid Tissue -- drug effects KW - Point Mutation -- genetics KW - Interleukin-7 -- metabolism KW - Interleukin-7 -- deficiency KW - Interleukin-7 -- genetics KW - Ethylnitrosourea -- pharmacology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70207183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genetics&rft.atitle=Functional+deficiency+in+IL-7+caused+by+an+N-ethyl-N-nitrosourea-induced+point+mutation.&rft.au=Feng%2C+Jianxun%3BWang%2C+Hongsheng%3BMorse%2C+Herbert+C&rft.aulast=Feng&rft.aufirst=Jianxun&rft.date=2007-02-01&rft.volume=175&rft.issue=2&rft.spage=545&rft.isbn=&rft.btitle=&rft.title=Genetics&rft.issn=00166731&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-02-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 2000 Feb 15;164(4):1961-70 [10657646] J Immunol. 2006 Sep 1;177(5):2749-54 [16920907] Mamm Genome. 2000 Jul;11(7):594-7 [10886029] Immunity. 2001 May;14(5):617-29 [11371363] J Immunol. 2001 Aug 1;167(3):1254-62 [11466341] J Exp Med. 2001 Oct 15;194(8):1141-50 [11602642] Nat Genet. 2002 Mar;30(3):255-6 [11850622] Nat Rev Immunol. 2002 May;2(5):323-35 [12033738] Mol Immunol. 2003 Jan;39(12):753-60 [12531286] Nat Immunol. 2003 Aug;4(8):773-9 [12872121] Eur J Immunol. 2004 Oct;34(10):2642-6 [15368279] J Exp Med. 1988 Mar 1;167(3):988-1002 [3258354] Nature. 1988 Jun 9;333(6173):571-3 [3259677] J Leukoc Biol. 1990 Sep;48(3):205-12 [2144014] Cell. 1992 May 29;69(5):823-31 [1591779] J Exp Med. 1993 Jul 1;178(1):257-64 [8315381] J Exp Med. 1993 Sep 1;178(3):1109-14 [8350050] Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9125-9 [8415665] Cell. 1994 Jun 3;77(5):737-47 [8205622] J Exp Med. 1994 Nov 1;180(5):1955-60 [7964471] J Exp Med. 1995 Apr 1;181(4):1519-26 [7699333] J Clin Invest. 1995 Jun;95(6):2945-53 [7769137] Genes Dev. 1995 Sep 15;9(18):2203-13 [7557375] Immunology. 1997 Nov;92(3):374-80 [9486111] Nat Genet. 1998 Dec;20(4):394-7 [9843216] J Exp Med. 1999 Jan 18;189(2):319-30 [9892614] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3000-5 [10077626] Eur J Immunol. 2004 Dec;34(12):3595-603 [15495160] J Immunol. 2005 Jun 1;174(11):6571-6 [15905493] Immunity. 2005 Sep;23(3):297-308 [16169502] Mol Immunol. 2006 Feb;43(4):326-34 [16310046] Semin Immunol. 2006 Feb;18(1):20-30 [16303314] Genesis. 2000 Feb;26(2):99-109 [10686599] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptors and chromatin remodeling machinery. AN - 69037061; 17240047 AB - Eukaryotic genetic information is stored within the association of DNA and histone proteins resulting in a dynamic polymer called chromatin. The fundamental structural unit of chromatin is the nucleosome which consists of approximately 146 bp of DNA wrapped around an octamer of histones containing two copies each of four core histones, H2A, H2B, H3 and H4. It is this DNA/protein fiber that transcription factors and other agents of chromatin metabolism must access and regulate. We have developed model systems to study the mechanisms by which steroid receptors control physiological activities by regulating gene expression within a higher order chromatin organization. Our studies have focused on the glucocorticoid receptor and its ability to remodel chromatin which is mediated by the BRG1 complex. Using novel cell systems, we demonstrate that GR-mediated transactivation from chromatin templates requires BRG1 remodeling activity and that other ATP-dependent remodeling proteins cannot substitute for this activity. JF - Molecular and cellular endocrinology AU - Trotter, Kevin W AU - Archer, Trevor K AD - Chromatin and Gene Expression Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T.W. Alexander Drive, P.O. Box 12233 (MD C4-06), Research Triangle Park, NC 27709, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 162 EP - 167 VL - 265-266 SN - 0303-7207, 0303-7207 KW - Chromosomal Proteins, Non-Histone KW - 0 KW - Histones KW - Receptors, Glucocorticoid KW - SWI-SNF-B chromatin-remodeling complex KW - Transcription Factors KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Animals KW - Humans KW - Histones -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Chromosomal Proteins, Non-Histone -- metabolism KW - Transcriptional Activation KW - Transcription Factors -- metabolism KW - Chromatin Assembly and Disassembly KW - Receptors, Glucocorticoid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69037061?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+endocrinology&rft.atitle=Nuclear+receptors+and+chromatin+remodeling+machinery.&rft.au=Trotter%2C+Kevin+W%3BArcher%2C+Trevor+K&rft.aulast=Trotter&rft.aufirst=Kevin&rft.date=2007-02-01&rft.volume=265-266&rft.issue=&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+endocrinology&rft.issn=03037207&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-02-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Feb;3(2):239-45 [10078206] Genes Dev. 2003 Nov 15;17(22):2733-40 [14630937] Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15603-8 [15501915] Vitam Horm. 2005;70:281-307 [15727808] Mol Cell. 2005 Mar 18;17(6):805-15 [15780937] Genes Dev. 2005 Jul 15;19(14):1662-7 [15985610] Nat Struct Mol Biol. 2006 Jan;13(1):22-9 [16341228] Chromosome Res. 2006;14(1):83-94 [16506098] J Biol Chem. 2006 Aug 11;281(32):22656-64 [16769725] Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12457-62 [16895995] Curr Opin Genet Dev. 2000 Apr;10(2):187-92 [10753786] J Biol Chem. 2000 Jun 9;275(23):17771-7 [10748103] Mol Cell Biol. 2000 Dec;20(23):8879-88 [11073988] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13015-20 [11078522] Cell. 2001 Mar 9;104(5):631-4 [11257215] Oncogene. 2001 May 28;20(24):3166-73 [11420733] EMBO J. 2001 Jul 16;20(14):3781-8 [11447119] Front Biosci. 2001 Sep 1;6:D1054-64 [11532604] Mol Cell. 2001 Dec;8(6):1219-30 [11779498] Nature. 2001 Dec 20-27;414(6866):924-8 [11780067] Curr Opin Genet Dev. 2002 Apr;12(2):142-8 [11893486] EMBO J. 2002 Aug 1;21(15):4094-103 [12145209] Biochim Biophys Acta. 2002 Oct 2;1603(1):19-29 [12242108] J Biol Chem. 2002 Nov 1;277(44):41674-85 [12200431] Cell. 2002 Nov 1;111(3):369-79 [12419247] J Steroid Biochem Mol Biol. 2003 Dec;87(4-5):223-31 [14698202] Biochim Biophys Acta. 2004 Mar 15;1677(1-3):30-45 [15020043] J Cell Biochem. 2004 Apr 15;91(6):1087-98 [15048866] Mol Cell Biol. 2004 Apr;24(8):3347-58 [15060156] Essays Biochem. 2004;40:73-88 [15242340] J Cell Sci. 2004 Aug 1;117(Pt 17):3707-11 [15286171] Genes Dev. 2004 Oct 15;18(20):2437-68 [15489290] Science. 1992 Mar 20;255(5051):1573-6 [1347958] Science. 1992 Dec 4;258(5088):1598-604 [1360703] EMBO J. 1993 Nov;12(11):4279-90 [8223438] Mol Cell Biol. 1994 Apr;14(4):2225-34 [7908117] Nucleic Acids Res. 1994 May 25;22(10):1815-20 [8208605] Genes Dev. 1996 Sep 1;10(17):2117-30 [8804307] EMBO J. 1996 Oct 1;15(19):5370-82 [8895581] Gene. 1997 Mar 25;188(1):95-100 [9099865] Nature. 1998 May 7;393(6680):88-91 [9590696] Mol Cell. 2002 Dec;10(6):1441-52 [12504018] Nature. 2003 Jan 23;421(6921):448-53 [12540921] Cell. 2003 Apr 18;113(2):207-19 [12705869] EMBO J. 2003 May 1;22(9):2146-55 [12727881] Mol Cell. 2003 May;11(5):1311-22 [12769854] Genes Dev. 2003 Jun 1;17(11):1392-401 [12782657] Recent Prog Horm Res. 2003;58:199-226 [12795420] Cell. 2003 Jun 27;113(7):905-17 [12837248] Mol Cell Biol. 2003 Sep;23(17):6210-20 [12917342] Cell. 2003 Nov 14;115(4):425-35 [14622597] Mol Cell. 1999 Feb;3(2):247-53 [10078207] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of IL-6 in an IL-10 and IL-4 double knockout mouse model uniquely susceptible to acetaminophen-induced liver injury. AN - 69018378; 17305405 AB - Drug-induced hepatitis remains a challenging problem for drug development and safety because of the lack of animal models. In the current work, we discovered a unique interaction that makes mice deficient in both IL-10 and IL-4 (IL-10/4-/-) highly sensitive to the hepatotoxic effects of acetaminophen (APAP). Male C57Bl/6 wild type (WT) and mice deficient in one or more cytokines were treated with 120 mg/kg APAP. Within 24 h after WT, IL-10-/-, IL-4-/-, or IL-10/4-/- mice were administered APAP, 75% of the IL-10/4-/- mice died of massive hepatic injury while all other genotypes were resistant to liver toxicity at this dose of APAP. The unique susceptibility of IL-10/4-/- mice was associated with reduced levels of liver glutathione and remarkably high serum levels of IL-6 and several proinflammatory factors including TNF-alpha, IFN-gamma, macrophage inflammatory protein-1alpha (MIP-1alpha), monocyte chemoattractant protein-1 (MCP-1), macrophage inflammatory protein-2 (MIP-2), and osteopontin (OPN) as well as nitric oxide (NO). IL-6 appeared to have a causal role in controlling the unique susceptibility of IL-10/4-/- mice to APAP-induced liver disease (AILD) because IL-6 neutralizing antibody reversed the high sensitivity of these mice to AILD. Moreover, IL-10/4/6-/- mice were also resistant to the enhanced susceptibility to AILD and expressed relatively low levels of most proinflammatory factor genes that were elevated in the IL-10/4-/- mice. In conclusion, liver homeostasis following AILD appears to be highly dependent on the activities of both IL-10 and IL-4, which together help prevent overexpression of IL-6 and other potential hepatotoxic factors. JF - Chemical research in toxicology AU - Bourdi, Mohammed AU - Eiras, Daniel P AU - Holt, Michael P AU - Webster, Marie R AU - Reilly, Timothy P AU - Welch, Kevin D AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. bourdim@nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 208 EP - 216 VL - 20 IS - 2 SN - 0893-228X, 0893-228X KW - Antibodies KW - 0 KW - Biomarkers KW - Interleukin-6 KW - Interleukin-10 KW - 130068-27-8 KW - Interleukin-4 KW - 207137-56-2 KW - Nitric Oxide KW - 31C4KY9ESH KW - Acetaminophen KW - 362O9ITL9D KW - Interferons KW - 9008-11-1 KW - Arginase KW - EC 3.5.3.1 KW - Glutathione KW - GAN16C9B8O KW - Index Medicus KW - Interferons -- biosynthesis KW - Animals KW - Liver -- pathology KW - Glutathione -- metabolism KW - Nitric Oxide -- blood KW - Liver -- metabolism KW - Mice KW - Nitric Oxide -- biosynthesis KW - Glutathione -- drug effects KW - Mice, Knockout KW - Liver -- drug effects KW - Antibodies -- pharmacology KW - Arginase -- biosynthesis KW - Genetic Predisposition to Disease KW - Arginase -- antagonists & inhibitors KW - Biomarkers -- blood KW - Chemical and Drug Induced Liver Injury -- blood KW - Interleukin-4 -- genetics KW - Acetaminophen -- administration & dosage KW - Chemical and Drug Induced Liver Injury -- pathology KW - Interleukin-4 -- deficiency KW - Disease Models, Animal KW - Interleukin-10 -- deficiency KW - Interleukin-6 -- blood KW - Interleukin-6 -- physiology KW - Interleukin-6 -- antagonists & inhibitors KW - Interleukin-10 -- genetics KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69018378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Role+of+IL-6+in+an+IL-10+and+IL-4+double+knockout+mouse+model+uniquely+susceptible+to+acetaminophen-induced+liver+injury.&rft.au=Bourdi%2C+Mohammed%3BEiras%2C+Daniel+P%3BHolt%2C+Michael+P%3BWebster%2C+Marie+R%3BReilly%2C+Timothy+P%3BWelch%2C+Kevin+D%3BPohl%2C+Lance+R&rft.aulast=Bourdi&rft.aufirst=Mohammed&rft.date=2007-02-01&rft.volume=20&rft.issue=2&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides. AN - 69016556; 17305411 AB - A synthetic route to oligonucleotides containing N(2)-deoxyguanosine adducts at C-10 of the enantiomeric 7,8-diol 9,10-epoxides of 7,8,9,10-tetrahydrobenzo[a]pyrene in which the epoxide oxygen and the 7-hydroxyl group are trans is described. The present adducts result from the trans addition of N(2) of deoxyguanosine to the epoxide at C-10. Our synthesis proceeds via preparation of the 3'-H-phosphonate of a suitably protected deoxyguanosine N(2)-adduct. The blocking groups consisted of O(6)-allyl on the deoxyguanosine, acetates on the 7-, 8-, and 9-hydroxyl groups of the hydrocarbon moiety, and dimethoxytrityl on the 5'-hydroxyl group of the sugar. These blocking groups are well suited to oligonucleotide synthesis on solid supports. The free 3'-hydroxyl group of this nucleoside adduct was readily converted to its 3'-H-phosphonate with diphenyl phosphite in pyridine in high yield for both the 10R and 10S isomers. For synthesis of oligonucleotides, the first several nucleotides were incorporated onto the solid support with an automated synthesizer using standard phosphoramidite chemistry. The adducted deoxyguanilic acid residue was introduced as the H-phosphonate in a manual step (80% yield), followed by completion of the sequence on the synthesizer. Although a 10-fold excess of the 3'-H-phosphonate was used in the manual coupling step, as much as 70% of the reactant could be recovered. The 3'-H-phosphonate of the protected 10S nucleoside adduct was converted to the unblocked nucleotide adduct, various salts of which failed to form crystals suitable for X-ray analysis. Although submilligram quantities of this compound have been formed as mixed diastereomers by direct reaction of deoxyguanylic acid with racemic diol epoxide, the present study represents the first actual synthesis of the major DNA adduct formed from benzo[a]pyrene in mammals as its 3'-phosphate. JF - Chemical research in toxicology AU - Iyer, Prema C AU - Yagi, Haruhiko AU - Sayer, Jane M AU - Jerina, Donald M AD - Laboratory of Bioorganic Chemistry, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 311 EP - 315 VL - 20 IS - 2 SN - 0893-228X, 0893-228X KW - Oligonucleotides KW - 0 KW - Organophosphonates KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide KW - 55097-80-8 KW - Deoxyguanosine KW - G9481N71RO KW - Index Medicus KW - Sensitivity and Specificity KW - Stereoisomerism KW - Magnetic Resonance Spectroscopy -- methods KW - Chromatography, High Pressure Liquid -- methods KW - Molecular Conformation KW - Time Factors KW - Organophosphonates -- chemistry KW - Oligonucleotides -- chemistry KW - Organophosphonates -- chemical synthesis KW - Oligonucleotides -- chemical synthesis KW - Deoxyguanosine -- chemistry KW - 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69016556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=3%27-H-phosphonate+synthesis+of+chiral+benzo%5Ba%5Dpyrene+diol+epoxide+adducts+at+N%282%29+of+deoxyguanosine+in+oligonucleotides.&rft.au=Iyer%2C+Prema+C%3BYagi%2C+Haruhiko%3BSayer%2C+Jane+M%3BJerina%2C+Donald+M&rft.aulast=Iyer&rft.aufirst=Prema&rft.date=2007-02-01&rft.volume=20&rft.issue=2&rft.spage=311&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-15 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of polVR391: a Y-family polymerase encoded by rumA'B from the IncJ conjugative transposon, R391. AN - 69011117; 17302804 AB - Although best characterized for their ability to traverse a variety of DNA lesions, Y-family DNA polymerases can also give rise to elevated spontaneous mutation rates if they are allowed to replicate undamaged DNA. One such enzyme that promotes high levels of spontaneous mutagenesis in Escherichia coli is polV(R391), a polV-like Y-family polymerase encoded by rumA'B from the IncJ conjugative transposon R391. When expressed in a DeltaumuDC lexA(Def) recA730 strain, polV(R391) promotes higher levels of spontaneous mutagenesis than the related MucA'B (polR1) or UmuD'C (polV) polymerases respectively. Analysis of the spectrum of polV(R391)-dependent mutations in rpoB revealed a unique genetic fingerprint that is typified by an increase in C:G-->A:T and A:T-->T:A transversions at certain mutagenic hot spots. Biochemical characterization of polV(R391) highlights the exceptional ability of the enzyme to misincorporate T opposite C and T in sequence contexts corresponding to mutagenic hot spots. Purified polV(R391) can also bypass a T-T pyrimidine dimer efficiently and displays greater accuracy opposite the 3'T of the dimer than opposite an undamaged T. Our study therefore provides evidence for the molecular basis for the enhanced spontaneous mutator activity of RumA'B, as well as explains its ability to promote efficient and accurate bypass of T-T pyrimidine dimers in vivo. JF - Molecular microbiology AU - Mead, Samantha AU - Vaisman, Alexandra AU - Valjavec-Gratian, Majda AU - Karata, Kiyonobu AU - Vandewiele, Dominique AU - Woodgate, Roger AD - Laboratory of Genomic Integrity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2725, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 797 EP - 810 VL - 63 IS - 3 SN - 0950-382X, 0950-382X KW - DNA Transposable Elements KW - 0 KW - Escherichia coli Proteins KW - DNA-Directed DNA Polymerase KW - EC 2.7.7.7 KW - polV(R391) protein, E coli KW - Index Medicus KW - Gene Expression Regulation, Bacterial KW - SOS Response (Genetics) KW - Mutagenesis KW - Escherichia coli Proteins -- metabolism KW - Escherichia coli -- genetics KW - Escherichia coli -- enzymology KW - DNA-Directed DNA Polymerase -- genetics KW - Escherichia coli Proteins -- genetics KW - DNA-Directed DNA Polymerase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69011117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Characterization+of+polVR391%3A+a+Y-family+polymerase+encoded+by+rumA%27B+from+the+IncJ+conjugative+transposon%2C+R391.&rft.au=Mead%2C+Samantha%3BVaisman%2C+Alexandra%3BValjavec-Gratian%2C+Majda%3BKarata%2C+Kiyonobu%3BVandewiele%2C+Dominique%3BWoodgate%2C+Roger&rft.aulast=Mead&rft.aufirst=Samantha&rft.date=2007-02-01&rft.volume=63&rft.issue=3&rft.spage=797&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-13 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). AN - 69009138; 17301694 AB - Cyclooxygenase-1 (COX-1, PTGS1) catalyzes the conversion of arachidonic acid to prostaglandin H2, which is subsequently metabolized to various biologically active prostaglandins. We sought to identify and characterize the functional relevance of genetic polymorphisms in PTGS1. Sequence variations in human PTGS1 were identified by resequencing 92 healthy individuals (24 African, 24 Asian, 24 European/Caucasian, and 20 anonymous). Using site-directed mutagenesis and a baculovirus/insect cell expression system, recombinant wild-type COX-1 and the R8W, P17L, R53H, R78W, K185T, G230S, L237M, and V481I variant proteins were expressed. COX-1 metabolic activity was evaluated in vitro using an oxygen consumption assay under basal conditions and in the presence of indomethacin. Forty-five variants were identified, including seven nonsynonymous polymorphisms encoding amino acid substitutions in the COX-1 protein. The R53H (35+/-5%), R78W (36+/-4%), K185T (59+/-6%), G230S (57+/-4%), and L237M (51+/-3%) variant proteins had significantly lower metabolic activity relative to wild-type (100+/-7%), while no significant differences were observed with the R8W (104+/-10%), P17L (113+/-7%), and V481I (121+/-10%) variants. Inhibition studies with indomethacin demonstrated that the P17L and G230S variants had significantly lower IC50 values compared to wild-type, suggesting these variants significantly increase COX-1 sensitivity to indomethacin inhibition. Consistent with the metabolic activity data, protein modeling suggested the G230S variant may disrupt the active conformation of COX-1. Our findings demonstrate that several genetic variants in human COX-1 significantly alter basal COX-1-mediated arachidonic acid metabolism and indomethacin-mediated inhibition of COX-1 activity in vitro. Future studies characterizing the functional impact of these variants in vivo are warranted. JF - Pharmacogenetics and genomics AU - Lee, Craig R AU - Bottone, Frank G AU - Krahn, Joseph M AU - Li, Leping AU - Mohrenweiser, Harvey W AU - Cook, Molly E AU - Petrovich, Robert M AU - Bell, Douglas A AU - Eling, Thomas E AU - Zeldin, Darryl C AD - Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Chapel Hill, North Carolina, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 145 EP - 160 VL - 17 IS - 2 SN - 1744-6872, 1744-6872 KW - Enzyme Inhibitors KW - 0 KW - Membrane Proteins KW - Mutant Proteins KW - Arachidonic Acid KW - 27YG812J1I KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - PTGS1 protein, human KW - Indomethacin KW - XXE1CET956 KW - Index Medicus KW - Mutant Proteins -- genetics KW - Protein Structure, Secondary KW - Mutant Proteins -- metabolism KW - Humans KW - Dimerization KW - Molecular Sequence Data KW - Enzyme Inhibitors -- pharmacology KW - Microsomes -- enzymology KW - Amino Acid Sequence KW - Inhibitory Concentration 50 KW - Linkage Disequilibrium KW - Arachidonic Acid -- metabolism KW - Polymorphism, Single Nucleotide KW - Cyclooxygenase 1 -- chemistry KW - Membrane Proteins -- chemistry KW - Cyclooxygenase 1 -- metabolism KW - Membrane Proteins -- metabolism KW - Membrane Proteins -- antagonists & inhibitors KW - Cyclooxygenase 1 -- genetics KW - Membrane Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69009138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Identification+and+functional+characterization+of+polymorphisms+in+human+cyclooxygenase-1+%28PTGS1%29.&rft.au=Lee%2C+Craig+R%3BBottone%2C+Frank+G%3BKrahn%2C+Joseph+M%3BLi%2C+Leping%3BMohrenweiser%2C+Harvey+W%3BCook%2C+Molly+E%3BPetrovich%2C+Robert+M%3BBell%2C+Douglas+A%3BEling%2C+Thomas+E%3BZeldin%2C+Darryl+C&rft.aulast=Lee&rft.aufirst=Craig&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-24 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochim Biophys Acta. 1999 Nov 23;1441(2-3):278-87 [10570255] Clin Pharmacol Ther. 2006 May;79(5):407-18 [16678543] Nature. 2000 May 4;405(6782):97-101 [10811226] J Biol Chem. 2001 Mar 30;276(13):10347-57 [11121412] J Pharmacol Exp Ther. 2001 Nov;299(2):468-76 [11602656] Mol Pharmacol. 2002 Apr;61(4):840-52 [11901223] J Pharmacol Exp Ther. 2002 Jun;301(3):1126-31 [12023546] Blood Coagul Fibrinolysis. 2002 Sep;13(6):519-31 [12192304] Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1631-6 [12377741] Hum Mutat. 2002 Nov;20(5):409-10 [12402351] Clin Pharmacol Ther. 2003 Jan;73(1):122-30 [12545150] Nucleic Acids Res. 2003 Jul 1;31(13):3497-500 [12824352] Mol Pharmacol. 2003 Aug;64(2):482-90 [12869654] Thromb Res. 2003;112(5-6):275-83 [15041270] FASEB J. 2004 May;18(7):790-804 [15117884] JAMA. 2004 May 12;291(18):2221-8 [15138244] Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):889-93 [15159324] Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W615-9 [15215462] Biochem Biophys Res Commun. 1989 Dec 15;165(2):888-94 [2512924] J Biol Chem. 1990 Nov 25;265(33):20073-6 [2122967] Biochem Biophys Res Commun. 1993 Jan 29;190(2):406-11 [8427584] Nature. 1994 Jan 20;367(6460):243-9 [8121489] Biochim Biophys Acta. 1994 Nov 16;1209(1):130-9 [7947975] Biochem J. 1995 Jan 15;305 ( Pt 2):479-84 [7832763] J Biol Chem. 1996 Jan 26;271(4):2179-84 [8567676] J Comput Biol. 1994 Fall;1(3):191-8 [8790464] Nature. 1996 Dec 19-26;384(6610):644-8 [8967954] J Biol Chem. 1996 Dec 27;271(52):33157-60 [8969167] Genome Res. 1998 Dec;8(12):1229-31 [9872978] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] J Pharmacol Exp Ther. 2005 Aug;314(2):923-31 [15914676] Eur Respir J. 2005 Aug;26(2):249-56 [16055872] Circulation. 2005 Aug 2;112(5):759-70 [16061757] J Thromb Haemost. 2005 Oct;3(10):2340-5 [16150050] J Clin Invest. 2006 Jan;116(1):4-15 [16395396] Gastroenterology. 2006 Jan;130(1):55-64 [16401468] J Biol Chem. 2000 Mar 24;275(12):8501-7 [10722687] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Common genetic variation in TP53 is associated with lung cancer risk and prognosis in African Americans and somatic mutations in lung tumors. AN - 69007237; 17301252 AB - Lung cancer is primarily caused by tobacco smoking, but susceptibility is likely modified by common genetic variation. In response to many forms of cellular stress, including DNA damage, the p53 protein functions to induce cell cycle arrest, DNA repair, senescence, or apoptosis. We hypothesized that common TP53 haplotypes modulate pathways of lung carcinogenesis and lung cancer susceptibility or prognosis. To investigate our hypothesis, 14 polymorphisms in TP53, including haplotype tagging and coding single nucleotide polymorphisms, were genotyped in two studies from the greater Baltimore, Maryland area. One study is a case-control study and the second is a case-only study for which TP53 mutational spectra data are available. African Americans with Pro-T-A-G-G haplotypes of the combined TP53 polymorphisms TP53_01 (rs1042522), TP53_65 (rs9895829), TP53_66 (rs2909430), TP53_16 (rs1625895), and TP53_11 (rs12951053) had both an increased risk for lung cancer (odds ratio, 2.32; 95% confidence interval, 1.18-4.57) and a worsened lung cancer prognosis (hazards ratio, 2.38; 95% confidence interval, 1.38-4.10) compared with those with Arg-T-A-G-T haplotypes. No associations of TP53 polymorphisms with lung cancer were observed in Caucasians. In the case-only study, several polymorphisms in TP53 and TP53 haplotypes, overlapping regions of TP53 associated with risk and prognosis in African Americans, were associated with increased odds of somatic TP53 mutation in lung tumors in Caucasians. In conclusion, common genetic variation in TP53 could modulate lung cancer pathways, as suggested by the association with lung cancer in African Americans and somatic TP53 mutation frequency in lung tumors. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Mechanic, Leah E AU - Bowman, Elise D AU - Welsh, Judith A AU - Khan, Mohammed A AU - Hagiwara, Nobutoshi AU - Enewold, Lindsey AU - Shields, Peter G AU - Burdette, Laurie AU - Chanock, Stephen AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, Bethesda, Maryland 20892-4258, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 214 EP - 222 VL - 16 IS - 2 SN - 1055-9965, 1055-9965 KW - Tumor Suppressor Protein p53 KW - 0 KW - Index Medicus KW - Polymorphism, Genetic KW - Chi-Square Distribution KW - DNA Mutational Analysis KW - Humans KW - Prognosis KW - Aged KW - European Continental Ancestry Group -- statistics & numerical data KW - Genotype KW - Risk KW - Haplotypes KW - Logistic Models KW - Case-Control Studies KW - Middle Aged KW - Maryland -- epidemiology KW - Genetic Predisposition to Disease KW - Female KW - Male KW - Survival Analysis KW - Proportional Hazards Models KW - Genetic Variation KW - Lung Neoplasms -- epidemiology KW - African Americans -- statistics & numerical data KW - Lung Neoplasms -- genetics KW - Tumor Suppressor Protein p53 -- genetics KW - Lung Neoplasms -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69007237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Common+genetic+variation+in+TP53+is+associated+with+lung+cancer+risk+and+prognosis+in+African+Americans+and+somatic+mutations+in+lung+tumors.&rft.au=Mechanic%2C+Leah+E%3BBowman%2C+Elise+D%3BWelsh%2C+Judith+A%3BKhan%2C+Mohammed+A%3BHagiwara%2C+Nobutoshi%3BEnewold%2C+Lindsey%3BShields%2C+Peter+G%3BBurdette%2C+Laurie%3BChanock%2C+Stephen%3BHarris%2C+Curtis+C&rft.aulast=Mechanic&rft.aufirst=Leah&rft.date=2007-02-01&rft.volume=16&rft.issue=2&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Residual tobacco smoke: measurement of its washout time in the lung and of its contribution to environmental tobacco smoke. AN - 69002091; 17297070 AB - Tobacco smoking entails inhaling millions of fine particles with each puff, and it is intuitive that after smoking a cigarette it will take a certain time to washout residual tobacco smoke (RTS) from the lungs with subsequent breaths. To study the washout time of 0.3-1.0 microm particles after the last puff in 10 volunteer smokers by using equipment capable of measuring particle concentration in real time in the exhaled air. Mean (standard deviation (SD)) lung RTS washout time was 58.6 (23.6) s, range 18-90 s, and corresponded to 8.7 (4.6) subsequent breathings. The contribution of individual and overall RTS to indoor pollution was calculated by subtracting incremental background particle concentration from room concentration after 10 consecutive re-entries of smokers after the last puff into a room of 33.2 m3, with an air exchange rate per hour in the range of 0.2-0.4. Mean (SD) individual RTS contribution consisted of 1402 (1490) million particles (range 51-3611 million), whereas RTS increased room 0.3-1.0 microm particle concentration from a baseline of 22,283 particles/l to a final room concentration of 341,956 particles/l, corresponding to a total increase in particulate matter (2.5) from a background of 0.56 up to 3.32 microg/m3. These data reveal a definite although marginal, role of RTS as a source of hidden indoor pollution. Further studies are needed to understand the relevance of this contribution in smoke-free premises in terms of risk exposure; however, waiting for about 2 min before re-entry after the last puff would be enough to avoid an unwanted additional exposure for non-smokers. JF - Tobacco control AU - Invernizzi, Giovanni AU - Ruprecht, Ario AU - De Marco, Cinzia AU - Paredi, Paolo AU - Boffi, Roberto AD - Tobacco Control Unit, National Cancer Institute and SIMG Italian College GPs, Milan, Italy. ginverni@clavis.it Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 29 EP - 33 VL - 16 IS - 1 KW - Air Pollutants KW - 0 KW - Tobacco Smoke Pollution KW - Index Medicus KW - Smoking KW - Particle Size KW - Humans KW - Exhalation KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Italy KW - Female KW - Air Pollution, Indoor -- analysis KW - Air Pollutants -- pharmacokinetics KW - Tobacco Smoke Pollution -- analysis KW - Lung -- metabolism KW - Air Pollutants -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69002091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tobacco+control&rft.atitle=Residual+tobacco+smoke%3A+measurement+of+its+washout+time+in+the+lung+and+of+its+contribution+to+environmental+tobacco+smoke.&rft.au=Invernizzi%2C+Giovanni%3BRuprecht%2C+Ario%3BDe+Marco%2C+Cinzia%3BParedi%2C+Paolo%3BBoffi%2C+Roberto&rft.aulast=Invernizzi&rft.aufirst=Giovanni&rft.date=2007-02-01&rft.volume=16&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Tobacco+control&rft.issn=1468-3318&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-07 N1 - Date created - 2007-02-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Epidemiology. 2000 Jan;11(1):6-10 [10615836] Inhal Toxicol. 2006 Apr;18(4):255-94 [22397322] Environ Health Perspect. 2002 Jul;110(7):689-98 [12117646] Eur Respir J. 2002 Jul;20(1):198-209 [12166570] Environ Health Perspect. 2003 Jul;111(9):1265-72 [12842784] Environ Health Perspect. 2004 Jun;112(8):932-41 [15175185] Tob Control. 2004 Sep;13(3):219-21 [15333875] Inhal Toxicol. 2004 Sep;16(10):675-89 [15371056] Science. 1980 May 2;208(4443):464-72 [7367873] Environ Health Perspect. 1996 Oct;104 Suppl 5:861-9 [8933027] Am Ind Hyg Assoc J. 1999 May-Jun;60(3):334-9 [10386354] Circulation. 2005 May 24;111(20):2684-98 [15911719] Environ Health Perspect. 2005 Sep;113(9):1140-7 [16140618] BMJ. 2005 Nov 12;331(7525):1117 [16230313] Biomarkers. 2006 May-Jun;11(3):221-32 [16760131] Epidemiol Prev. 2002 Jan-Feb;26(1):30-4 [11942144] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A pilot study of CTLA-4 blockade after cancer vaccine failure in patients with advanced malignancy. AN - 68993245; 17289891 AB - Eleven patients with progressive advanced malignancy after administration of a cancer vaccine received a fully human anti-CTLA-4 monoclonal antibody (ipilimumab). The primary end point was to determine drug toxicity. Tumor response, tumor-specific CD8+ T-cell immune responses, and modulation of CD4+ CD25+ FoxP3+ regulatory T-cell (Treg) numbers were secondary end points. Three patients with colon cancer, four with non-Hodgkin's lymphoma, and four with prostate cancer were treated. The first dose was given at 3 mg/kg and subsequent doses were administered monthly at 1.5 mg/kg for a total of four cycles. Tumor regression was observed in two patients with lymphoma; one of which obtained a partial response of 14-month duration. Ipilimumab was well tolerated with predominantly grade 1/2 toxicities. One drug-related grade 3 toxicity was observed. One patient died within 30 days of treatment due to progressive colon cancer. No increase in vaccine-specific T-cell responses was observed after therapy. Tregs as detected by expression of CD4+CD25+CD62L+ declined at early time points but rebounded to levels at or above baseline values at the time of the next infusion. Ipilimumab treatment depressed Treg numbers at early time points in the treatment cycle but was not accompanied by an increase in vaccine-specific CD8+ T-cell responses in these patients previously treated with a variety of investigational anticancer vaccines. A partial response was observed in one patient with follicular lymphoma. A phase I/II trial evaluating ipilimumab in patients with follicular lymphoma is currently ongoing. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - O'Mahony, Deirdre AU - Morris, John C AU - Quinn, Cate AU - Gao, Wendy AU - Wilson, Wyndham H AU - Gause, Barry AU - Pittaluga, Stefania AU - Neelapu, Sattva AU - Brown, Margaret AU - Fleisher, Thomas A AU - Gulley, James L AU - Schlom, Jeffrey AU - Nussenblatt, Robert AU - Albert, Paul AU - Davis, Thomas A AU - Lowy, Israel AU - Petrus, Mike AU - Waldmann, Thomas A AU - Janik, John E AD - Metabolism Branch, Laboratory of Pathology, Department of Laboratory Medicine, National Eye Institute, Bethesda, MD 20892-1457, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 958 EP - 964 VL - 13 IS - 3 SN - 1078-0432, 1078-0432 KW - Antigens, CD KW - 0 KW - Antigens, Differentiation KW - Antineoplastic Agents KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Cancer Vaccines KW - Interleukin-2 Receptor alpha Subunit KW - L-Selectin KW - 126880-86-2 KW - Prostate-Specific Antigen KW - EC 3.4.21.77 KW - Index Medicus KW - CD8-Positive T-Lymphocytes -- metabolism KW - Humans KW - Aged KW - Pilot Projects KW - Prostate-Specific Antigen -- biosynthesis KW - CD4-Positive T-Lymphocytes -- metabolism KW - Adult KW - L-Selectin -- biosynthesis KW - Neoplasm Metastasis KW - Middle Aged KW - Antineoplastic Agents -- pharmacology KW - Female KW - Male KW - Interleukin-2 Receptor alpha Subunit -- biosynthesis KW - Prostatic Neoplasms -- pathology KW - Lymphoma, Non-Hodgkin -- drug therapy KW - Antigens, Differentiation -- metabolism KW - Colonic Neoplasms -- drug therapy KW - Antigens, CD -- metabolism KW - Prostatic Neoplasms -- drug therapy KW - Colonic Neoplasms -- pathology KW - Lymphoma, Non-Hodgkin -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68993245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+pilot+study+of+CTLA-4+blockade+after+cancer+vaccine+failure+in+patients+with+advanced+malignancy.&rft.au=O%27Mahony%2C+Deirdre%3BMorris%2C+John+C%3BQuinn%2C+Cate%3BGao%2C+Wendy%3BWilson%2C+Wyndham+H%3BGause%2C+Barry%3BPittaluga%2C+Stefania%3BNeelapu%2C+Sattva%3BBrown%2C+Margaret%3BFleisher%2C+Thomas+A%3BGulley%2C+James+L%3BSchlom%2C+Jeffrey%3BNussenblatt%2C+Robert%3BAlbert%2C+Paul%3BDavis%2C+Thomas+A%3BLowy%2C+Israel%3BPetrus%2C+Mike%3BWaldmann%2C+Thomas+A%3BJanik%2C+John+E&rft.aulast=O%27Mahony&rft.aufirst=Deirdre&rft.date=2007-02-01&rft.volume=13&rft.issue=3&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-04 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Clin Cancer Res. 2007 Feb 1;13(3):785-8 [17289867] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mechanisms of disease: hereditary leiomyomatosis and renal cell cancer--a distinct form of hereditary kidney cancer. AN - 68991051; 17287871 AB - Renal cell carcinoma (RCC) represents a group of diseases linked by their primary site of origin, the kidney. Studies of families with a genetic predisposition to the development of kidney cancer have revealed that multiple genes are involved in the molecular pathogenesis of RCC. Germline mutations in a gene that encodes a Krebs cycle enzyme have been found to result in a distinct clinical entity referred to as hereditary leiomyomatosis and renal cell cancer (HLRCC). HLRCC is inherited in an autosomal-dominant fashion. Affected individuals in HLRCC families are at risk for the development of leiomyomas of the skin and uterus as well as renal cancers. HLRCC-associated kidney tumors are often biologically aggressive. Linkage analysis has identified germline alterations in the fumarate hydratase (FH) gene associated with HLRCC. While the mechanisms of molecular carcinogenesis are not entirely understood, several lines of evidence derived from clinical and basic research suggest that pseudohypoxia might drive cellular transformation. The role of FH mutations in sporadic tumors seems to be limited. Nevertheless, continued investigation of HLRCC should provide further insight into the mechanisms of kidney cancer development, and could potentially identify targets for new therapeutic approaches to RCC. JF - Nature clinical practice. Urology AU - Sudarshan, Sunil AU - Pinto, Peter A AU - Neckers, Len AU - Linehan, W Marston AD - Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1107, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 104 EP - 110 VL - 4 IS - 2 KW - Index Medicus KW - Humans KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Carcinoma, Renal Cell -- metabolism KW - Leiomyomatosis -- metabolism KW - Kidney Neoplasms -- metabolism KW - Leiomyomatosis -- genetics KW - Carcinoma, Renal Cell -- genetics KW - Leiomyomatosis -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68991051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+clinical+practice.+Urology&rft.atitle=Mechanisms+of+disease%3A+hereditary+leiomyomatosis+and+renal+cell+cancer--a+distinct+form+of+hereditary+kidney+cancer.&rft.au=Sudarshan%2C+Sunil%3BPinto%2C+Peter+A%3BNeckers%2C+Len%3BLinehan%2C+W+Marston&rft.aulast=Sudarshan&rft.aufirst=Sunil&rft.date=2007-02-01&rft.volume=4&rft.issue=2&rft.spage=104&rft.isbn=&rft.btitle=&rft.title=Nature+clinical+practice.+Urology&rft.issn=1743-4289&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-30 N1 - Date created - 2007-02-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of peroxisome proliferator-activated receptor-gamma in macrophage suppresses experimentally induced colitis. AN - 68990812; 17095756 AB - Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been shown to be a protective transcription factor in mouse models of inflammatory bowel disease (IBD). PPAR-gamma is expressed in several different cell types, and mice with a targeted disruption of the PPAR-gamma gene in intestinal epithelial cells demonstrated increased susceptibility to dextran sulfate sodium (DSS)-induced IBD. However, the highly selective PPAR-gamma ligand rosiglitazone decreased the severity of DSS-induced colitis and suppressed cytokine production in both PPAR-gamma intestinal specific null mice and wild-type littermates. Therefore the role of PPAR-gamma in different tissues and their contribution to the pathogenesis of IBD still remain unclear. Mice with a targeted disruption of PPAR-gamma in macrophages (PPAR-gamma(DeltaMphi)) and wild-type littermates (PPAR-gamma(F/F)) were administered 2.5% DSS in drinking water to induce IBD. Typical clinical symptoms were evaluated on a daily basis, and proinflammatory cytokine analysis was performed. PPAR-gamma(DeltaMphi) mice displayed an increased susceptibility to DSS-induced colitis compared with wild-type littermates, as defined by body weight loss, diarrhea, rectal bleeding score, colon length, and histology. IL-1beta, CCR2, MCP-1, and inducible nitric oxide synthase mRNA levels in colons of PPAR-gamma(DeltaMphi) mice treated with DSS were higher than in similarly treated PPAR-gamma(F/F) mice. The present study has identified a novel protective role for macrophage PPAR-gamma in the DSS-induced IBD model. The data suggest that PPAR-gamma regulates recruitment of macrophages to inflammatory foci in the colon. JF - American journal of physiology. Gastrointestinal and liver physiology AU - Shah, Yatrik M AU - Morimura, Keiichirou AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - G657 EP - G666 VL - 292 IS - 2 SN - 0193-1857, 0193-1857 KW - Antigens, CD KW - 0 KW - Antigens, CD36 KW - Antigens, Differentiation, Myelomonocytic KW - CD68 protein, mouse KW - Ccr2 protein, mouse KW - Chemokine CCL2 KW - Cytokines KW - Fabp4 protein, mouse KW - Fatty Acid-Binding Proteins KW - Marco protein, mouse KW - PPAR gamma KW - RNA, Messenger KW - Receptors, CCR2 KW - Receptors, Chemokine KW - Receptors, Immunologic KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Dextran Sulfate KW - 9042-14-2 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Colon -- pathology KW - Fatty Acid-Binding Proteins -- genetics KW - Dextran Sulfate -- toxicity KW - RNA, Messenger -- genetics KW - Mice, Knockout KW - Neutrophils -- metabolism KW - Dendritic Cells -- metabolism KW - Receptors, Immunologic -- metabolism KW - Thiazolidinediones -- pharmacology KW - Chemokine CCL2 -- pharmacology KW - Cell Movement -- drug effects KW - Antigens, CD36 -- genetics KW - Receptors, Chemokine -- metabolism KW - Cytokines -- metabolism KW - Mice KW - Mice, Inbred Strains KW - Blotting, Western KW - RNA, Messenger -- metabolism KW - Colon -- metabolism KW - Body Weight -- drug effects KW - Antigens, CD -- metabolism KW - Antigens, Differentiation, Myelomonocytic -- metabolism KW - Nitric Oxide Synthase Type II -- metabolism KW - PPAR gamma -- metabolism KW - Colitis -- chemically induced KW - Macrophages -- drug effects KW - Colitis -- genetics KW - Colitis -- metabolism KW - PPAR gamma -- genetics KW - PPAR gamma -- agonists KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68990812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.atitle=Expression+of+peroxisome+proliferator-activated+receptor-gamma+in+macrophage+suppresses+experimentally+induced+colitis.&rft.au=Shah%2C+Yatrik+M%3BMorimura%2C+Keiichirou%3BGonzalez%2C+Frank+J&rft.aulast=Shah&rft.aufirst=Yatrik&rft.date=2007-02-01&rft.volume=292&rft.issue=2&rft.spage=G657&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Gastrointestinal+and+liver+physiology&rft.issn=01931857&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-16 N1 - Date created - 2007-02-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biochimie. 1997 Feb-Mar;79(2-3):111-2 [9209705] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4318-23 [9113987] J Pharmacol Exp Ther. 1998 Dec;287(3):1048-55 [9864291] J Clin Invest. 1999 Mar;103(6):773-8 [10079097] Atherosclerosis. 1999 Mar;143(1):205-11 [10208497] J Clin Invest. 1999 Aug;104(4):383-9 [10449430] Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):1997-2008 [15319268] Curr Mol Med. 2004 Nov;4(7):763-75 [15579023] Eur J Pharmacol. 2005 Jan 31;508(1-3):255-65 [15680279] Inflamm Bowel Dis. 2005 Mar;11(3):231-43 [15735429] Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):6207-12 [15833818] Biochem Biophys Res Commun. 2005 Jun 24;332(1):188-93 [15896316] Biochem Pharmacol. 2005 Jun 15;69(12):1733-44 [15876425] Mol Immunol. 2005 Jul;42(11):1303-10 [15950726] Int Immunol. 2005 Aug;17(8):1023-34 [16000328] Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1647-53 [15947238] Nature. 2005 Sep 29;437(7059):759-63 [16127449] Ann Allergy Asthma Immunol. 2005 Nov;95(5):468-73 [16312170] Gut. 2006 Aug;55(8):1104-13 [16547072] Mol Cell. 1999 Oct;4(4):611-7 [10549292] Scand J Gastroenterol. 1999 Nov;34(11):1117-22 [10582763] Transgenic Res. 1999 Aug;8(4):265-77 [10621974] J Immunol. 2000 Jun 15;164(12):6303-12 [10843684] J Clin Invest. 2000 Aug;106(4):467-72 [10953021] J Clin Invest. 2000 Sep;106(6):793-802 [10995790] Nat Med. 2001 Jan;7(1):48-52 [11135615] Eur J Clin Invest. 2001 Mar;31(3):234-9 [11264651] Eur Cytokine Netw. 2001 Mar;12(1):111-8 [11282554] Free Radic Biol Med. 2001 Jul 15;31(2):153-63 [11440827] J Exp Med. 2001 Nov 5;194(9):1207-18 [11696587] Mol Cell Biol. 2002 Apr;22(8):2607-19 [11909955] Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8 [12426226] Dig Dis Sci. 2003 Feb;48(2):408-14 [12643623] Redox Rep. 2002;7(5):283-9 [12688511] J Gastroenterol. 2003 Mar;38 Suppl 15:59-62 [12698874] Gastroenterology. 2003 May;124(5):1265-76 [12730867] Gastroenterology. 2003 May;124(5):1315-24 [12730872] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7 [12740443] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15712-7 [14660788] Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4543-7 [15070754] Am J Physiol Gastrointest Liver Physiol. 2004 Oct;287(4):G865-74 [15217783] Gastroenterology. 2004 Sep;127(3):777-91 [15362034] J Clin Invest. 1990 Sep;86(3):972-80 [2168444] Gastroenterology. 1992 Jul;103(1):65-71 [1535326] Lab Invest. 1993 Aug;69(2):238-49 [8350599] Gastroenterology. 1994 Feb;106(2):533-9 [8299918] Annu Rev Biochem. 1994;63:451-86 [7979245] Chem Biol Interact. 1995 May 19;96(2):203-6 [7728908] Am J Physiol. 1995 May;268(5 Pt 1):L699-722 [7762673] J Biol Chem. 1995 Jun 2;270(22):12953-6 [7768881] Gastroenterology. 1995 Oct;109(4):1344-67 [7557106] Cell. 1995 Dec 1;83(5):813-9 [8521498] Nature. 1998 Aug 27;394(6696):894-7 [9732872] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Leptin induces an Apc genotype-associated colon epithelial cell chemokine production pattern associated with macrophage chemotaxis and activation. AN - 68984431; 16891627 AB - Leptin is an adipocyte-derived cytokine associated with obesity and inflammation recently shown to influence colon epithelial cell fate and colon inflammation. Thus, the purpose of this study is to investigate the influences of leptin exposure on the production of proinflammatory signals by a model of normal [YAMC (Apc+/+)] and preneoplastic [IMCE (ApcMin/+)] colon epithelial cells. Here, we characterize the production of specific CC and CXC chemokines by IMCE and YAMC cells using an antibody-based cytokine array. Further, since epithelial cells are hypothesized to be accessory to the inflammatory response, we assessed the ability of supernants from leptin-exposed colon epithelial cells to activate macrophage chemotaxis and nitric oxide production. Both YAMC and IMCE cells produced the following chemokines from the CC family; MCP-1, MIP-3alpha, TCA-3, CTACK and RANTES. These cell lines also produced the following CXC chemokines; MIP-2, CXCL18, KC and LIX. Conditioned media from leptin-treated YAMC and IMCE cells induced nitric oxide production by macrophages (P<0.05). However, only conditioned media from leptin-treated IMCE cells induced macrophage chemotaxis (P<0.05). These data imply that preneoplastic but not normal cells may selectively attract immune cells that promote their survival and transformation. Taken together with our previous data, we conclude that leptin promotes the proliferation of a model of preneoplastic cells (IMCE) and induces the production of chemokines which may activate macrophages and promote macrophage cell chemotaxis. These data provide a rational basis for leptin-induced cross-talk between preneoplastic epithelial cells and immune cells that may influence the promotional phase of carcinogenesis. JF - Carcinogenesis AU - Fenton, Jenifer I AU - Hursting, Stephen D AU - Perkins, Susan N AU - Hord, Norman G AD - Cancer Prevention Fellowship Program, Division of Cancer Prevention, National Cancer Institute Bethesda, MD, USA. imigjeni@msu.edu Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 455 EP - 464 VL - 28 IS - 2 SN - 0143-3334, 0143-3334 KW - Chemokines KW - 0 KW - Culture Media, Conditioned KW - Leptin KW - Index Medicus KW - Genotype KW - Epithelial Cells -- metabolism KW - Animals KW - Mice KW - Cell Line KW - Macrophages -- cytology KW - Colon -- metabolism KW - Colon -- cytology KW - Chemokines -- biosynthesis KW - Macrophage Activation -- physiology KW - Leptin -- physiology KW - Genes, APC KW - Chemotaxis, Leukocyte -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68984431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Leptin+induces+an+Apc+genotype-associated+colon+epithelial+cell+chemokine+production+pattern+associated+with+macrophage+chemotaxis+and+activation.&rft.au=Fenton%2C+Jenifer+I%3BHursting%2C+Stephen+D%3BPerkins%2C+Susan+N%3BHord%2C+Norman+G&rft.aulast=Fenton&rft.aufirst=Jenifer&rft.date=2007-02-01&rft.volume=28&rft.issue=2&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase II study of second-line neoadjuvant chemotherapy with capecitabine and radiation therapy for anthracycline-resistant locally advanced breast cancer. AN - 68982754; 17278899 AB - According to data from Brazil's National Cancer Institute nearly 30% of the new patients who present with breast cancer have locally advanced disease. These patients are inoperable and tumor reduction is usually attempted with chemotherapy. First-line anthracyclin-based neoadjuvant chemotherapy is often effective; however, about 30% of the patients fail and to date there is no established second-line treatment. We have studied the concomitant use of radiation therapy and capecitabine in this setting, to determine the toxicity and efficacy of this regimen as a second-line neoadjuvant treatment. Twenty-eight patients with inoperable locally advanced breast cancer refractory to first-line anthracycline based treatment were enrolled between January 2003 and May 2004. Patients received radiation therapy (total dose 5000 cGy) and concomitant capecitabine (850 mg/m2) twice daily for 14 days every 3 weeks. This treatment rendered 23 of the 28 patients (82%) operable. The 5 remaining patients did not undergo surgery because of disease progression. The median clinical tumor size decreased from 80 cm2 to 49 cm2. Microscopic residual disease was observed in 3 patients (13%) and another patient achieved a complete pathologic response. The median number of involved lymph nodes was 2 and treatment was well tolerated with no grade 3 or 4 events. Our data indicate that second-line neoadjuvant treatment with radiation therapy and capecitabine is feasible, well tolerated, and effective in patients with locally advanced breast cancer refractory to primary anthracycline-based treatment. These results suggest that a randomized study should be done to compare radiotherapy alone to capecitabine combined with radiotherapy. JF - American journal of clinical oncology AU - Gaui, Maria de Fátima Dias AU - Amorim, Gilberto AU - Arcuri, Roberto Alfonso AU - Pereira, Guilherme AU - Moreira, Denise AU - Djahjah, Célia AU - Biasoli, Irene AU - Spector, Nelson AD - Oncology and Pathology Services, National Cancer Institute, Rio de Janeiro, Brazil. mfgaui@hotmail.com Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 78 EP - 81 VL - 30 IS - 1 KW - Anthracyclines KW - 0 KW - Antimetabolites, Antineoplastic KW - Receptors, Estrogen KW - Receptors, Progesterone KW - Deoxycytidine KW - 0W860991D6 KW - Capecitabine KW - 6804DJ8Z9U KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - Combined Modality Therapy -- methods KW - Neoplasm Invasiveness KW - Anthracyclines -- therapeutic use KW - Neoplasm Staging KW - Humans KW - Aged KW - Receptors, Estrogen -- analysis KW - Drug Resistance, Neoplasm KW - Receptors, Progesterone -- analysis KW - Adult KW - Middle Aged KW - Lymph Node Excision KW - Chemotherapy, Adjuvant KW - Female KW - Fluorouracil -- therapeutic use KW - Breast Neoplasms -- drug therapy KW - Deoxycytidine -- toxicity KW - Breast Neoplasms -- pathology KW - Fluorouracil -- toxicity KW - Deoxycytidine -- analogs & derivatives KW - Fluorouracil -- analogs & derivatives KW - Antimetabolites, Antineoplastic -- toxicity KW - Deoxycytidine -- therapeutic use KW - Breast Neoplasms -- surgery KW - Breast Neoplasms -- radiotherapy KW - Antimetabolites, Antineoplastic -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68982754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+clinical+oncology&rft.atitle=A+phase+II+study+of+second-line+neoadjuvant+chemotherapy+with+capecitabine+and+radiation+therapy+for+anthracycline-resistant+locally+advanced+breast+cancer.&rft.au=Gaui%2C+Maria+de+F%C3%A1tima+Dias%3BAmorim%2C+Gilberto%3BArcuri%2C+Roberto+Alfonso%3BPereira%2C+Guilherme%3BMoreira%2C+Denise%3BDjahjah%2C+C%C3%A9lia%3BBiasoli%2C+Irene%3BSpector%2C+Nelson&rft.aulast=Gaui&rft.aufirst=Maria+de+F%C3%A1tima&rft.date=2007-02-01&rft.volume=30&rft.issue=1&rft.spage=78&rft.isbn=&rft.btitle=&rft.title=American+journal+of+clinical+oncology&rft.issn=1537-453X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-06 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Am J Clin Oncol. 2007 Jun;30(3):331 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lead promotes abasic site accumulation and co-mutagenesis in mammalian cells by inhibiting the major abasic endonuclease Ape1. AN - 68980678; 17013835 AB - Lead is a widespread environmental toxin, found in contaminated water sources, household paints, and certain occupational settings. Classified as a probable carcinogen by the International Agency for Research on Cancer (IARC), lead promotes mutagenesis when combined with alkylating and oxidizing DNA-damaging agents. We previously reported that lead inhibits the in vitro repair activity of Ape1, the major endonuclease for repairing mutagenic and cytotoxic abasic sites in DNA. We investigated here whether lead targets Ape1 in cultured mammalian cells. We report a concentration-dependent inhibition of apurinic/apyrimidinic (AP) site incision activity of Chinese hamster ovary (CHO) AA8 whole cell extracts by lead. In addition, lead exposure results in a concentration-dependent accumulation of AP sites in the genomic DNA of AA8 cells. An increase in the oxidative base lesion 8-oxoguanine was observed only at high lead levels (500 microM), suggesting that non-specific oxidation plays little role in the production of lead-related AP lesions at physiological metal concentrations--a conclusion corroborated by "thiobarbituric acid reactive substances" assays. Notably, Ape1 overexpression in AA8 (hApe1-3 cell line) abrogated the lead-dependent increase in AP site steady-state levels. Moreover, lead functioned cooperatively to promote a further increase in abasic sites with agents known to generate AP sites in DNA (i.e., methyl methansulfonate (MMS) and hydrogen peroxide (H2O2), but not the DNA crosslinking agent mitomycin C. Hypoxanthine guanine phosphoribosyltransferase (hprt) mutation analysis revealed that, whereas lead alone had no effect on mutation frequencies, mutagenesis increased in MMS treated, and to a greater extent lead/MMS treated, AA8 cells. With the hApe1-3 cell line, the number of mutant colonies in all treatment groups was found to be equal to that of the background level, indicating that Ape1 overexpression reverses MMS- and lead-associated hprt mutagenesis. Our studies in total indicate that Ape1 is a member of an emerging group of DNA surveillance proteins that are inhibited by environmental heavy metals, and suggest an underlying mechanism by which lead promotes co-carcinogenesis. JF - Molecular carcinogenesis AU - McNeill, Daniel R AU - Wong, Heng-Kuan AU - Narayana, Avinash AU - Wilson, David M AD - Laboratory of Molecular Gerontology, GRC, National Institute on Aging, IRP, NIH, Baltimore, Maryland 21224-6825, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 91 EP - 99 VL - 46 IS - 2 SN - 0899-1987, 0899-1987 KW - Mutagens KW - 0 KW - Thiobarbituric Acid Reactive Substances KW - Lead KW - 2P299V784P KW - Hypoxanthine Phosphoribosyltransferase KW - EC 2.4.2.8 KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - Index Medicus KW - Thiobarbituric Acid Reactive Substances -- metabolism KW - Animals KW - Hypoxanthine Phosphoribosyltransferase -- genetics KW - Cricetulus KW - DNA Damage KW - Mutagens -- toxicity KW - CHO Cells KW - Cell Line KW - Mutagenesis KW - Cricetinae KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- antagonists & inhibitors KW - Lead -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68980678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Lead+promotes+abasic+site+accumulation+and+co-mutagenesis+in+mammalian+cells+by+inhibiting+the+major+abasic+endonuclease+Ape1.&rft.au=McNeill%2C+Daniel+R%3BWong%2C+Heng-Kuan%3BNarayana%2C+Avinash%3BWilson%2C+David+M&rft.aulast=McNeill&rft.aufirst=Daniel&rft.date=2007-02-01&rft.volume=46&rft.issue=2&rft.spage=91&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-26 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fatal leukoencephalopathy after reduced-intensity allogeneic stem cell transplantation. AN - 68962384; 17264526 AB - Toxicity associated with immunosuppression and conditioning regimens represents a common cause of neurological complications after allogeneic stem cell transplantation. We present a 56-year-old female patient with refractory acute lymphoblastic leukemia undergoing reduced-intensity conditioning with fludarabine, BCNU and melphalan followed by matched-sibling allogeneic stem cell transplantation. Under immunosuppressive treatment with cyclosporine A (CSA) the patient developed early-onset (day +33) and ultimately fatal leukoencephalopathy. As fludarabine and CSA represent two key substances of today's reduced-intensity conditioning regimens we raise the question of whether CSA, fludarabine or a combination of both led to this outcome and discuss differential diagnoses. JF - Onkologie AU - Mielke, Stephan AU - Potthoff, Karin AU - Feuerhake, Friedrich AU - Bley, Thorsten A AU - Windfuhr, Marisa AU - Bertz, Hartmut AU - Finke, Jürgen AD - Department of Hematology and Oncology, University of Freiburg Medical Center, Freiburg i. Br., Germany. mielkes@nhlbi.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 49 EP - 52 VL - 30 IS - 1-2 SN - 0378-584X, 0378-584X KW - Antineoplastic Agents KW - 0 KW - Immunosuppressive Agents KW - Cyclosporine KW - 83HN0GTJ6D KW - Vidarabine KW - FA2DM6879K KW - fludarabine KW - P2K93U8740 KW - Melphalan KW - Q41OR9510P KW - Carmustine KW - U68WG3173Y KW - Index Medicus KW - Fatal Outcome KW - Combined Modality Therapy KW - Humans KW - Risk Assessment KW - Melphalan -- administration & dosage KW - Melphalan -- adverse effects KW - Middle Aged KW - Carmustine -- adverse effects KW - Stem Cell Transplantation KW - Carmustine -- administration & dosage KW - Female KW - Immunosuppressive Agents -- administration & dosage KW - Immunosuppressive Agents -- adverse effects KW - Vidarabine -- analogs & derivatives KW - Cyclosporine -- administration & dosage KW - Cyclosporine -- adverse effects KW - Demyelinating Diseases -- diagnosis KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- surgery KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Vidarabine -- administration & dosage KW - Vidarabine -- adverse effects KW - Demyelinating Diseases -- chemically induced KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68962384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Onkologie&rft.atitle=Fatal+leukoencephalopathy+after+reduced-intensity+allogeneic+stem+cell+transplantation.&rft.au=Mielke%2C+Stephan%3BPotthoff%2C+Karin%3BFeuerhake%2C+Friedrich%3BBley%2C+Thorsten+A%3BWindfuhr%2C+Marisa%3BBertz%2C+Hartmut%3BFinke%2C+J%C3%BCrgen&rft.aulast=Mielke&rft.aufirst=Stephan&rft.date=2007-02-01&rft.volume=30&rft.issue=1-2&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Onkologie&rft.issn=0378584X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular dissection and expression of the LdK39 kinesin in the human pathogen, Leishmania donovani. AN - 68961900; 17257310 AB - In this study we show for the first time the intracellular distribution of a K39 kinesin homologue in Leishmania donovani, a medically important parasite of humans. Further, we demonstrated that this motor protein is expressed in both the insect and mammalian developmental forms (i.e. promastigote and amastigotes) of this organism. Moreover, in both of these parasite developmental stages, immunofluorescence indicated that the LdK39 kinesin accumulated at anterior and posterior cell poles and that it displayed a peripheral localization consistent with the cortical cytoskeleton. Using a molecular approach, we identified, cloned and characterized the first complete open reading frame for the gene (LdK39) encoding this large (> 358 kDa) motor protein in L. donovani. Based on these observations, we subsequently used a homologous episomal expression system to dissect and express the functional domains that constitute the native molecule. Cell fractionation experiments demonstrated that LdK39 was soluble and that it bound to detergent-extracted cytoskeletons of these parasites in an ATP-dependent manner. The cumulative results of these experiments are consistent with LdK39 functioning as an ATP-dependent kinesin which binds to and travels along the cortical cytoskeleton of this important human pathogen. JF - Molecular microbiology AU - Gerald, Noel J AU - Coppens, Isabelle AU - Dwyer, Dennis M AD - Cell Biology Section, Laboratory of Parasitic Diseases, NIAID/NIH, Bethesda, MD, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 962 EP - 979 VL - 63 IS - 4 SN - 0950-382X, 0950-382X KW - Antigens, Protozoan KW - 0 KW - Detergents KW - Protozoan Proteins KW - Recombinant Fusion Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Sodium Azide KW - 968JJ8C9DV KW - Deoxyglucose KW - 9G2MP84A8W KW - K39 antigen, Leishmania KW - EC 3.6.1.- KW - Kinesin KW - EC 3.6.4.4 KW - Index Medicus KW - Phylogeny KW - Animals KW - Cytoskeleton -- metabolism KW - Deoxyglucose -- chemistry KW - Humans KW - Cloning, Molecular KW - Green Fluorescent Proteins -- genetics KW - Recombinant Fusion Proteins -- metabolism KW - Detergents -- chemistry KW - Sodium Azide -- chemistry KW - Cytoplasm -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Green Fluorescent Proteins -- metabolism KW - Protozoan Proteins -- metabolism KW - Antigens, Protozoan -- genetics KW - Protozoan Proteins -- genetics KW - Leishmania donovani -- chemistry KW - Kinesin -- genetics KW - Antigens, Protozoan -- metabolism KW - Kinesin -- metabolism KW - Leishmania donovani -- physiology KW - Leishmania donovani -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68961900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+microbiology&rft.atitle=Molecular+dissection+and+expression+of+the+LdK39+kinesin+in+the+human+pathogen%2C+Leishmania+donovani.&rft.au=Gerald%2C+Noel+J%3BCoppens%2C+Isabelle%3BDwyer%2C+Dennis+M&rft.aulast=Gerald&rft.aufirst=Noel&rft.date=2007-02-01&rft.volume=63&rft.issue=4&rft.spage=962&rft.isbn=&rft.btitle=&rft.title=Molecular+microbiology&rft.issn=0950382X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - DQ831678; GENBANK N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid identification of functionally critical amino acids in a G protein-coupled receptor. AN - 68959606; 17206152 AB - G protein-coupled receptors (GPCRs) comprise one of the largest protein families found in nature. Here we describe a new experimental strategy that allows rapid identification of functionally critical amino acids in the rat M(3) muscarinic acetylcholine receptor (M3R), a prototypic class I GPCR. This approach involves low-frequency random mutagenesis of the entire M3R coding sequence, followed by the application of a new yeast genetic screen that allows the recovery of inactivating M3R single point mutations. The vast majority of recovered mutant M3Rs also showed substantial functional impairments in transfected mammalian (COS-7) cells. A subset of mutant receptors, however, behaved differently in yeast and mammalian cells, probably because of the specific features of the yeast expression system used. The screening strategy described here should be applicable to all GPCRs that can be expressed functionally in yeast. JF - Nature methods AU - Li, Bo AU - Scarselli, Marco AU - Knudsen, Christopher D AU - Kim, Soo-Kyung AU - Jacobson, Kenneth A AU - McMillin, Sara M AU - Wess, Jürgen AD - Molecular Signaling, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 169 EP - 174 VL - 4 IS - 2 SN - 1548-7091, 1548-7091 KW - Amino Acids KW - 0 KW - Receptor, Muscarinic M3 KW - Index Medicus KW - Rats KW - Polymerase Chain Reaction KW - Animals KW - COS Cells KW - Cercopithecus aethiops KW - Point Mutation KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Saccharomyces cerevisiae KW - Mutagenesis KW - Amino Acids -- analysis KW - Receptor, Muscarinic M3 -- chemistry KW - Receptor, Muscarinic M3 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68959606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+methods&rft.atitle=Rapid+identification+of+functionally+critical+amino+acids+in+a+G+protein-coupled+receptor.&rft.au=Li%2C+Bo%3BScarselli%2C+Marco%3BKnudsen%2C+Christopher+D%3BKim%2C+Soo-Kyung%3BJacobson%2C+Kenneth+A%3BMcMillin%2C+Sara+M%3BWess%2C+J%C3%BCrgen&rft.aulast=Li&rft.aufirst=Bo&rft.date=2007-02-01&rft.volume=4&rft.issue=2&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Nature+methods&rft.issn=15487091&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy. AN - 68957584; 17125767 AB - Pyridoxine (vitamin B6) intoxicated rodents develop a peripheral neuropathy characterized by sensory nerve conduction deficits associated with disturbances of nerve fiber geometry and axonal atrophy. To investigate the possibility that glucagon-like peptide-1 (7-36)-amide (GLP-1) receptor agonism may influence axonal structure and function through neuroprotection neurotrophic support, effects of GLP-1 and its long acting analog, Exendin-4 (Ex4) treatment on pyridoxine-induced peripheral neuropathy were examined in rats using behavioral and morphometric techniques. GLP-1 is an endogenous insulinotropic peptide secreted from the gut in response to the presence of food. GLP-1 receptors (GLP-1R) are coupled to the cAMP second messenger pathway, and are expressed widely throughout neural tissues of humans and rodents. Recent studies have established that GLP-1 and Ex4, have multiple synergistic effects on glucose-dependent insulin secretion pathways of pancreatic beta-cells and on neural plasticity. Data reported here suggest that clinically relevant doses of GLP-1 and Ex4 may offer some protection against the sensory peripheral neuropathy induced by pyridoxine. Our findings suggest a potential role for these peptides in the treatment of neuropathies, including that associated with type II diabetes mellitus. JF - Experimental neurology AU - Perry, TracyAnn AU - Holloway, Harold W AU - Weerasuriya, Ananda AU - Mouton, Peter R AU - Duffy, Kara AU - Mattison, Julie A AU - Greig, Nigel H AD - Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr., Baltimore, MD 21224, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 293 EP - 301 VL - 203 IS - 2 SN - 0014-4886, 0014-4886 KW - Blood Glucose KW - 0 KW - GLP1R protein, human KW - Glp1r protein, rat KW - Glucagon-Like Peptide-1 Receptor KW - Neuroprotective Agents KW - Peptides KW - Receptors, Glucagon KW - Venoms KW - Vitamins KW - Glucagon-Like Peptide 1 KW - 89750-14-1 KW - exenatide KW - 9P1872D4OL KW - Pyridoxine KW - KV2JZ1BI6Z KW - Index Medicus KW - Animals KW - Muscle Tonus -- physiology KW - Blood Glucose -- metabolism KW - Nerve Degeneration -- chemically induced KW - Amino Acid Sequence KW - Postural Balance -- drug effects KW - Rats KW - Behavior, Animal -- drug effects KW - Rats, Sprague-Dawley KW - Ganglia, Spinal -- pathology KW - Body Weight -- drug effects KW - Nerve Degeneration -- pathology KW - Molecular Sequence Data KW - Sciatic Nerve -- pathology KW - Male KW - Receptors, Glucagon -- agonists KW - Venoms -- therapeutic use KW - Neurons, Afferent KW - Peripheral Nervous System Diseases -- prevention & control KW - Peripheral Nervous System Diseases -- chemically induced KW - Glucagon-Like Peptide 1 -- physiology KW - Peptides -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68957584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+neurology&rft.atitle=Evidence+of+GLP-1-mediated+neuroprotection+in+an+animal+model+of+pyridoxine-induced+peripheral+sensory+neuropathy.&rft.au=Perry%2C+TracyAnn%3BHolloway%2C+Harold+W%3BWeerasuriya%2C+Ananda%3BMouton%2C+Peter+R%3BDuffy%2C+Kara%3BMattison%2C+Julie+A%3BGreig%2C+Nigel+H&rft.aulast=Perry&rft.aufirst=TracyAnn&rft.date=2007-02-01&rft.volume=203&rft.issue=2&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Experimental+neurology&rft.issn=00144886&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Endocrinology. 2000 Apr;141(4):1301-9 [10746632] Curr Pharm Des. 2006;12(14):1731-50 [16712485] J Pharmacol Exp Ther. 2002 Sep;302(3):881-8 [12183643] J Neurosci Res. 2003 Jun 1;72(5):603-12 [12749025] Trends Pharmacol Sci. 2003 Jul;24(7):377-83 [12871671] Nat Med. 2003 Sep;9(9):1173-9 [12925848] Auton Neurosci. 2004 Jan 30;110(1):36-43 [14766323] Muscle Nerve. 2004 Sep;30(3):255-68 [15318336] Exp Neurol. 2004 Nov;190(1):133-44 [15473987] Agents Actions. 1982 Oct;12(4):575-82 [7180742] Neurology. 1985 Nov;35(11):1617-22 [2997659] Neurology. 1987 Nov;37(11):1729-32 [2823181] Toxicology. 1988 Apr;49(1):171-8 [3376123] Neurology. 1989 Aug;39(8):1077-83 [2761702] Nature. 1996 Jan 4;379(6560):69-72 [8538742] Eur J Neurosci. 1995 Nov 1;7(11):2294-300 [8563978] Endocrinology. 1996 Nov;137(11):5159-62 [8895391] J Clin Invest. 1997 Jun 15;99(12):2883-9 [9185511] Exp Gerontol. 1998 Sep;33(6):615-24 [9789738] Diabetologia. 1999 Jan;42(1):45-50 [10027577] Ann N Y Acad Sci. 2004 Dec;1035:290-315 [15681814] Curr Alzheimer Res. 2005 Jul;2(3):377-85 [15974903] Diabetologia. 2006 Feb;49(2):253-60 [16416146] J Clin Oncol. 2006 Apr 1;24(10):1633-42 [16575015] Curr Opin Investig Drugs. 2006 Apr;7(4):324-37 [16625819] J Pharmacol Exp Ther. 2002 Mar;300(3):958-66 [11861804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sirolimus therapy of focal segmental glomerulosclerosis is associated with nephrotoxicity. AN - 68956789; 17261434 AB - To evaluate the safety and efficacy of sirolimus in treating patients with focal segmental glomerulosclerosis (FSGS), we performed a phase 2, open-label clinical trial. Inclusion criteria were adults and children 13 years and older with biopsy-proven idiopathic FSGS, proteinuria with protein of 3.5 g/d or greater while on angiotensin antagonist therapy, glomerular filtration rate (GFR) of 30 mL/min/1.73 m(2) or greater (>or=0.50 mL/s), and failure to achieve sustained remission with at least 1 immunosuppressive agent. Eligible patients received sirolimus doses adjusted to achieve trough levels of 5 to 15 ng/mL during the first 4 months and 10 to 20 ng/mL for the subsequent 8 months. The primary outcome was decrease in proteinuria, expressed as complete remission (protein or= 50% decrease and 18 mmol/L) at 5 months in 1 patient. Because of a rapid decrease in GFR with worsening proteinuria, the protocol was closed to further recruitment. We conclude that sirolimus may be associated with nephrotoxicity in some patients with FSGS, particularly those with prolonged disease duration and prior cyclosporine therapy. JF - American journal of kidney diseases : the official journal of the National Kidney Foundation AU - Cho, Monique E AU - Hurley, John K AU - Kopp, Jeffrey B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-1268, USA. moniquec@intra.niddk.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 310 EP - 317 VL - 49 IS - 2 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Proteinuria -- physiopathology KW - Glomerular Filtration Rate -- physiology KW - Humans KW - Proteinuria -- complications KW - In Vitro Techniques KW - Adult KW - Middle Aged KW - Male KW - Female KW - Proteinuria -- chemically induced KW - Sirolimus -- adverse effects KW - Kidney Diseases -- physiopathology KW - Glomerulosclerosis, Focal Segmental -- drug therapy KW - Glomerulosclerosis, Focal Segmental -- physiopathology KW - Kidney Diseases -- complications KW - Kidney Diseases -- chemically induced KW - Glomerulosclerosis, Focal Segmental -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68956789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.atitle=Sirolimus+therapy+of+focal+segmental+glomerulosclerosis+is+associated+with+nephrotoxicity.&rft.au=Cho%2C+Monique+E%3BHurley%2C+John+K%3BKopp%2C+Jeffrey+B&rft.aulast=Cho&rft.aufirst=Monique&rft.date=2007-02-01&rft.volume=49&rft.issue=2&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=American+journal+of+kidney+diseases+%3A+the+official+journal+of+the+National+Kidney+Foundation&rft.issn=1523-6838&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alkylene tether-length dependent gamma-aminobutyric acid type A receptor competitive antagonism by tacrine dimers. AN - 68953568; 17056074 AB - Bis(7)-tacrine was previously demonstrated as an antagonist of gamma-aminobutyric acid type A (GABA(A)) receptors. In this study, the effects of a series of alkylene-linked tacrine dimers on GABA(A) receptors were examined. In radioligand binding assay, the analogues differed in binding affinity for GABA(A) receptors, and potency monotonically increased as the tether was shortened from nine to two methylenes. Bis(2)-tacrine, the shortest tacrine dimer, could displace [(3)H]muscimol from rat brain membranes with an IC(50) of 0.48 microM, which was 11, 13 and 525 times more potent than the GABA(A) receptor antagonist (+)-bicuculline, bis(7)-tacrine and tacrine, respectively. In whole-cell patch-clamp recordings, these dimeric tacrine analogues competitively antagonized GABA-induced inward current with a rank order of potency of bis(2)-tacrine>bicuculline>bis(7)-tacrine>bis(9)-tacrine>tacrine, and the potency of bis(2)-tacrine was 11, 18 and 487 times higher than that of (+)-bicuculline, bis(7)-tacrine and tacrine, respectively. Bis(2)-tacrine shifted the GABA concentration-response curve to the right in a parallel manner, and the inhibition was voltage-independent between -80 and +20 mV. It can be concluded that the shorter the alkylene linkage in tacrine dimers the stronger the binding affinity and higher the antagonistic effect on the GABA(A) receptor will be. JF - Neuropharmacology AU - Li, Chaoying AU - Carlier, Paul R AU - Ren, Hong AU - Kan, Kelvin K W AU - Hui, Kwokmin AU - Wang, Hong AU - Li, Wenming AU - Li, Zhiwang AU - Xiong, Keming AU - Clement, Ella Chow AU - Xue, Hong AU - Liu, Xiangou AU - Li, Mingtao AU - Pang, Yuanping AU - Han, Yifan AD - Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 436 EP - 443 VL - 52 IS - 2 SN - 0028-3908, 0028-3908 KW - GABA Antagonists KW - 0 KW - GABA-A Receptor Antagonists KW - Tacrine KW - 4VX7YNB537 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Bicuculline -- pharmacology KW - Animals KW - Drug Interactions KW - Models, Molecular KW - Dose-Response Relationship, Drug KW - gamma-Aminobutyric Acid -- pharmacology KW - Neurons -- drug effects KW - Dimerization KW - Membrane Potentials -- physiology KW - Radioligand Assay KW - Dose-Response Relationship, Radiation KW - Electric Stimulation KW - GABA Antagonists -- pharmacology KW - Alkylation -- drug effects KW - Structure-Activity Relationship KW - Rats KW - Ganglia, Spinal -- cytology KW - Rats, Sprague-Dawley KW - Patch-Clamp Techniques KW - Neurons -- physiology KW - Membrane Potentials -- drug effects KW - Inhibitory Concentration 50 KW - Male KW - Tacrine -- chemistry KW - Tacrine -- pharmacology KW - Tacrine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68953568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Alkylene+tether-length+dependent+gamma-aminobutyric+acid+type+A+receptor+competitive+antagonism+by+tacrine+dimers.&rft.au=Li%2C+Chaoying%3BCarlier%2C+Paul+R%3BRen%2C+Hong%3BKan%2C+Kelvin+K+W%3BHui%2C+Kwokmin%3BWang%2C+Hong%3BLi%2C+Wenming%3BLi%2C+Zhiwang%3BXiong%2C+Keming%3BClement%2C+Ella+Chow%3BXue%2C+Hong%3BLiu%2C+Xiangou%3BLi%2C+Mingtao%3BPang%2C+Yuanping%3BHan%2C+Yifan&rft.aulast=Li&rft.aufirst=Chaoying&rft.date=2007-02-01&rft.volume=52&rft.issue=2&rft.spage=436&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tamoxifen effect on L-DOPA induced response complications in parkinsonian rats and primates. AN - 68953269; 17116309 AB - The contribution of striatal protein kinase C (PKC) isoform changes in levodopa (L-DOPA) induced motor response complications in parkinsonian rats was investigated and the ability of tamoxifen, an antiestrogen with a partial PKC antagonist property, to prevent these response alterations in 6-hydroxydopamine (6-OHDA) lesioned rats as well as in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated cynomologous monkeys was studied. Following treatment of adult male rats with L-DOPA twice daily for 3 weeks, protein levels of left (lesioned) and right (intact) striatal PKC isoforms were measured. Western blot analysis showed increased protein expression of both the novel PKC epsilon isoform and the atypical PKC lambda isoform ipsilateral to the lesion (174+/-17% for epsilon, 140+/-9% for lambda, of intact striatum in 6-OHDA lesioned plus chronic L-DOPA treated animals) in acute L-DOPA treated rats. No enhancement was observed in PKC immunoreactivity for other isoforms. Tamoxifen (5.0 mg/kg p.o.) significantly attenuated the L-DOPA induced augmentation of protein expression of PKC epsilon and PKC lambda, but had no effect on immunoreactivity for other PKC isoforms. In chronic L-DOPA treated parkinsonian rats, tamoxifen prevented (5.0 mg/kg p.o.) as well as ameliorated (5.0 mg/kg p.o.) the characteristic shortening in duration of motor response to L-DOPA challenge. In MPTP lesioned primates, similar to the ameliorative effect seen in rats, tamoxifen (1 and 3 mg/kg p.o) reduced the appearance of L-DOPA induced dyskinesia by 61% and 55% respectively (p<0.05). These results suggest that changes in specific striatal PKC isoforms contribute to the pathogenesis of L-DOPA induced motor complications and further that drugs able to selectively inhibit these signaling kinases might provide adjunctive benefit in the treatment of Parkinson's disease. JF - Neuropharmacology AU - Smith, C P S AU - Oh, J D AU - Bibbiani, F AU - Collins, M A AU - Avila, I AU - Chase, T N AD - Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 515 EP - 526 VL - 52 IS - 2 SN - 0028-3908, 0028-3908 KW - Antiparkinson Agents KW - 0 KW - Nerve Tissue Proteins KW - Selective Estrogen Receptor Modulators KW - Tamoxifen KW - 094ZI81Y45 KW - Levodopa KW - 46627O600J KW - Oxidopamine KW - 8HW4YBZ748 KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - Protein Kinase C KW - EC 2.7.11.13 KW - Index Medicus KW - Animals KW - Parkinson Disease, Secondary -- chemically induced KW - Drug Administration Schedule KW - Drug Interactions KW - Disease Models, Animal KW - Models, Biological KW - Haplorhini KW - Parkinson Disease, Secondary -- drug therapy KW - Rats KW - Protein Kinase C -- metabolism KW - Rats, Sprague-Dawley KW - Nerve Tissue Proteins -- metabolism KW - Time Factors KW - Male KW - Antiparkinson Agents -- adverse effects KW - Dyskinesia, Drug-Induced -- drug therapy KW - Tamoxifen -- therapeutic use KW - Selective Estrogen Receptor Modulators -- therapeutic use KW - Dyskinesia, Drug-Induced -- etiology KW - Levodopa -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68953269?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Tamoxifen+effect+on+L-DOPA+induced+response+complications+in+parkinsonian+rats+and+primates.&rft.au=Smith%2C+C+P+S%3BOh%2C+J+D%3BBibbiani%2C+F%3BCollins%2C+M+A%3BAvila%2C+I%3BChase%2C+T+N&rft.aulast=Smith&rft.aufirst=C+P&rft.date=2007-02-01&rft.volume=52&rft.issue=2&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-10 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of subconjunctival and intrascleral drug delivery to the posterior segment using dynamic contrast-enhanced magnetic resonance imaging. AN - 68951332; 17251481 AB - Sustained-release intravitreal drug implants for posterior segment diseases are associated with significant complications. As an alternative, subconjunctival infusions of drug to the episclera of the back of the eye have been performed, but results in clinical trials for macular diseases showed mixed To improve understanding of transscleral drug delivery to the posterior segment, the distribution and clearance of gadolinium-diethylene-triamino-penta-acetic acid (Gd-DTPA) infused in the subconjunctival or intrascleral space was investigated by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). In anesthetized rabbits, catheters were placed anteriorly in the subconjunctival or intrascleral space and infused with Gd-DTPA at 1 and 10 muL/min. Distribution and clearance of Gd-DTPA were measured using DCE-MRI. Histologic examination was performed to assess ocular toxicity of the delivery system. results. Subconjunctival infusions failed to produce detectable levels of Gd-DTPA in the back of the eye. In contrast, intrascleral infusions expanded the suprachoroidal layer and delivered Gd-DTPA to the posterior segment. Suprachoroidal clearance of Gd-DTPA followed first-order kinetics with an average half-life of 5.4 and 11.8 minutes after intrascleral infusions at 1 and 10 muL/min, respectively. Histologic examination demonstrated expansion of the tissues in the suprachoroidal space that normalized after infusion termination. An intrascleral infusion was successful in transporting Gd-DTPA to the posterior segment from an anterior infusion site with limited anterior segment exposure. The suprachoroidal space appears to be an expandible conduit for drug transport to the posterior segment. Further studies are indicated to explore the feasibility of clinical applications. JF - Investigative ophthalmology & visual science AU - Kim, Stephanie H AU - Galbán, Craig J AU - Lutz, Robert J AU - Dedrick, Robert L AU - Csaky, Karl G AU - Lizak, Martin J AU - Wang, Nam Sun AU - Tansey, Ginger AU - Robinson, Michael R AD - Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland, USA. kimstep@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 808 EP - 814 VL - 48 IS - 2 SN - 0146-0404, 0146-0404 KW - Contrast Media KW - 0 KW - Gadolinium DTPA KW - K2I13DR72L KW - Index Medicus KW - Animals KW - Magnetic Resonance Imaging -- methods KW - Rabbits KW - Infusions, Parenteral KW - Female KW - Retina -- metabolism KW - Drug Delivery Systems KW - Gadolinium DTPA -- pharmacokinetics KW - Contrast Media -- pharmacokinetics KW - Sclera -- drug effects KW - Choroid -- metabolism KW - Gadolinium DTPA -- administration & dosage KW - Contrast Media -- administration & dosage KW - Conjunctiva -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68951332?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Assessment+of+subconjunctival+and+intrascleral+drug+delivery+to+the+posterior+segment+using+dynamic+contrast-enhanced+magnetic+resonance+imaging.&rft.au=Kim%2C+Stephanie+H%3BGalb%C3%A1n%2C+Craig+J%3BLutz%2C+Robert+J%3BDedrick%2C+Robert+L%3BCsaky%2C+Karl+G%3BLizak%2C+Martin+J%3BWang%2C+Nam+Sun%3BTansey%2C+Ginger%3BRobinson%2C+Michael+R&rft.aulast=Kim&rft.aufirst=Stephanie&rft.date=2007-02-01&rft.volume=48&rft.issue=2&rft.spage=808&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-01 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nutritional interactions: credentialing of molecular targets for cancer prevention. AN - 68949566; 17259324 AB - Dietary behavior has been identified as one of the most important modifiable determinants of cancer risk. Which personalized modifications are needed remains an area of considerable controversy. Part of this uncertainty may arise from interactions among dietary bioactive compounds and/or food combinations. These interactions may either enhance or negate the response to specific foods. Evidence suggests that the cancer-protective effects of an individual's diet may reflect the combined effects of various vitamins, minerals, and other bioactive components such as flavonoids, isothiocyanates, and/or allium compounds rather than from the effect of a single ingredient. A better understanding of physiologically important interactions is needed to determine the merit of combining foods for maximum efficacy for cancer prevention. Furthermore, the response is complicated, since multiple cellular processes associated with carcinogenesis can be modified simultaneously, including sites such as drug metabolism, DNA repair, cell proliferation, apoptosis, inflammation, differentiation, and angiogenesis. Current evidence suggests that bioactive food components can typically influence more than one process. It is essential to have a better understanding of how the response relates to exposures and credentialing which process is most involved in bringing about a change in tumor incidence and/or tumor behavior. Credentialing is being defined as a determination of which cellular process(es) and which bioactive food components are most important for bringing about a phenotypic change. Additional attention is needed to determine the critical intake of dietary components, their duration, and when they should be provided to optimize the desired physiological response. Further research is also needed on the molecular targets for bioactive components and whether genetic and epigenetic events dictate the direction and magnitude of the response. JF - Experimental biology and medicine (Maywood, N.J.) AU - Davis, Cindy D AD - Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6130 Executive Boulevard, Suite 3159, Rockville, MD 20892-7328, USA. davisci@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 176 EP - 183 VL - 232 IS - 2 SN - 1535-3702, 1535-3702 KW - Index Medicus KW - Humans KW - Neoplasms -- pathology KW - Neoplasms -- prevention & control KW - Diet UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68949566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.atitle=Nutritional+interactions%3A+credentialing+of+molecular+targets+for+cancer+prevention.&rft.au=Davis%2C+Cindy+D&rft.aulast=Davis&rft.aufirst=Cindy&rft.date=2007-02-01&rft.volume=232&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.issn=15353702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-22 N1 - Date created - 2007-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of human skin pigmentation and responses to ultraviolet radiation. AN - 68944222; 17250543 AB - Pigmentation of human skin is closely involved in protection against environmental stresses, in particular exposure to ultraviolet (UV) radiation. It is well known that darker skin is significantly more resistant to the damaging effects of UV, such as photocarcinogenesis and photoaging, than is lighter skin. Constitutive skin pigmentation depends on the amount of melanin and its distribution in that tissue. Melanin is significantly photoprotective and epidermal cells in darker skin incur less DNA damage than do those in lighter skin. This review summarizes current understanding of the regulation of constitutive human skin pigmentation and responses to UV radiation, with emphasis on physiological factors that influence those processes. Further research is needed to characterize the role of skin pigmentation to reduce photocarcinogenesis and to develop effective strategies to minimize such risks. JF - Pigment cell research AU - Miyamura, Yoshinori AU - Coelho, Sergio G AU - Wolber, Rainer AU - Miller, Sharon A AU - Wakamatsu, Kazumasa AU - Zmudzka, Barbara Z AU - Ito, Shosuke AU - Smuda, Christoph AU - Passeron, Thierry AU - Choi, Wonseon AU - Batzer, Jan AU - Yamaguchi, Yuji AU - Beer, Janusz Z AU - Hearing, Vincent J AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 2 EP - 13 VL - 20 IS - 1 SN - 0893-5785, 0893-5785 KW - Index Medicus KW - Skin -- radiation effects KW - Radiation Protection KW - Aging -- radiation effects KW - Humans KW - Skin -- cytology KW - Melanocytes -- cytology KW - Melanocytes -- radiation effects KW - Ultraviolet Rays KW - Skin Pigmentation -- radiation effects KW - Skin Pigmentation -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68944222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pigment+cell+research&rft.atitle=Regulation+of+human+skin+pigmentation+and+responses+to+ultraviolet+radiation.&rft.au=Miyamura%2C+Yoshinori%3BCoelho%2C+Sergio+G%3BWolber%2C+Rainer%3BMiller%2C+Sharon+A%3BWakamatsu%2C+Kazumasa%3BZmudzka%2C+Barbara+Z%3BIto%2C+Shosuke%3BSmuda%2C+Christoph%3BPasseron%2C+Thierry%3BChoi%2C+Wonseon%3BBatzer%2C+Jan%3BYamaguchi%2C+Yuji%3BBeer%2C+Janusz+Z%3BHearing%2C+Vincent+J&rft.aulast=Miyamura&rft.aufirst=Yoshinori&rft.date=2007-02-01&rft.volume=20&rft.issue=1&rft.spage=2&rft.isbn=&rft.btitle=&rft.title=Pigment+cell+research&rft.issn=08935785&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-19 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Induction of the formyl peptide receptor 2 in microglia by IFN-gamma and synergy with CD40 ligand. AN - 68939925; 17237425 AB - Human formyl peptide receptor (FPR)-like 1 (FPRL1) and its mouse homologue mFPR2 are functional receptors for a variety of exogenous and host-derived chemotactic peptides, including amyloid beta 1-42 (Abeta(42)), a pathogenic factor in Alzheimer's disease. Because mFPR2 in microglial cells is regulated by proinflammatory stimulants including TLR agonists, in this study we investigated the capacity of IFN-gamma and the CD40 ligand (CD40L) to affect the expression and function of mFPR2. We found that IFN-gamma, when used alone, induced mFPR2 mRNA expression in a mouse microglial cell line and primary microglial cells in association with increased cell migration in response to mFPR2 agonists, including Abeta(42). IFN-gamma also increased the endocytosis of Abeta(42) by microglial cells via mFPR2. The effect of IFN-gamma on mFPR2 expression in microglial cells was dependent on activation of MAPK and IkappaB-alpha. IFN-gamma additionally increased the expression of CD40 by microglial cells and soluble CD40L significantly promoted cell responses to IFN-gamma during a 6-h incubation period by enhancing the activation of MAPK and IkappaB-alpha signaling pathways. We additionally found that the effect of IFN-gamma and its synergy with CD40L on mFPR2 expression in microglia was mediated in part by TNF-alpha. Our results suggest that IFN-gamma and CD40L, two host-derived factors with increased concentrations in inflammatory central nervous system diseases, may profoundly affect microglial cell responses in the pathogenic process in which mFPR2 agonist peptides are elevated. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Chen, Keqiang AU - Iribarren, Pablo AU - Huang, Jian AU - Zhang, Lingzhi AU - Gong, Wanghua AU - Cho, Edward H AU - Lockett, Stephen AU - Dunlop, Nancy M AU - Wang, Ji Ming AD - Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 1759 EP - 1766 VL - 178 IS - 3 SN - 0022-1767, 0022-1767 KW - RNA, Messenger KW - 0 KW - Receptors, Formyl Peptide KW - Tumor Necrosis Factor-alpha KW - formyl peptide receptor 2, mouse KW - CD40 Ligand KW - 147205-72-9 KW - Interferon-gamma KW - 82115-62-6 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Tumor Necrosis Factor-alpha -- pharmacology KW - RNA, Messenger -- drug effects KW - Cell Movement -- drug effects KW - Mice KW - Drug Synergism KW - Signal Transduction KW - Microglia -- cytology KW - Interferon-gamma -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Receptors, Formyl Peptide -- genetics KW - Microglia -- metabolism KW - CD40 Ligand -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68939925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Induction+of+the+formyl+peptide+receptor+2+in+microglia+by+IFN-gamma+and+synergy+with+CD40+ligand.&rft.au=Chen%2C+Keqiang%3BIribarren%2C+Pablo%3BHuang%2C+Jian%3BZhang%2C+Lingzhi%3BGong%2C+Wanghua%3BCho%2C+Edward+H%3BLockett%2C+Stephen%3BDunlop%2C+Nancy+M%3BWang%2C+Ji+Ming&rft.aulast=Chen&rft.aufirst=Keqiang&rft.date=2007-02-01&rft.volume=178&rft.issue=3&rft.spage=1759&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age-dependent variation in behavior following acute ethanol administration in male and female adolescent rhesus macaques (Macaca mulatta). AN - 68939815; 17250614 AB - There has been considerable focus on the adolescent stage of development in the study of alcohol use and the etiology of alcohol-related problems. Because adolescence is a process of dynamic change rather than a discrete or static stage of development, it is important to consider ontogenetic changes in the response to ethanol within the adolescent time period. In rodents, levels of ethanol-induced motor impairment have been shown to increase from early to late adolescence. This study investigated associations between behavior following acute ethanol administration and age, rearing condition (mother-reared vs nursery-reared), and serotonin transporter (rh5-HTTLPR) genotype in a sample of alcohol-naïve adolescent rhesus macaques. Rhesus macaques (n=97; 41 males, 56 females), ranging in age from 28 to 48 months, were administered intravenous (IV) doses of ethanol (2.2 g/kg for males, 2.0 g/kg for females) twice in 2 separate testing sessions. A saline/ethanol group (n=16; 8 males, 6 females) was administered saline in 1 testing session and ethanol in the second session. Following each IV injection, subjects underwent a 30-minute general motor behavioral assessment. Behavior in the saline/ethanol group was compared between the saline and ethanol-testing sessions using analysis of variance. Behavioral data for the larger study sample were averaged between the 2 testing sessions and summarized using factor analysis. Rotated factor scores were used as dependent variables in multiple regression analyses to test for relationships between behavior and age, rearing condition, and rh5-HTTLPR genotype. During the ethanol-testing session, behaviors indicative of motor impairment (stumbles, falls, sways, bumping the wall, and unsuccessful jumps) were frequently observed in the saline/ethanol group, while they did not occur under the saline-testing session. Factor analysis of behavior following ethanol administration in the larger study sample yielded 3 factors: Ataxia, Impaired Jumping Ability, and Stimulation. Significant negative correlations between age and Ataxia were found for both males and females. Females also exhibited positive correlations between age and Impaired Jumping Ability and age and Stimulation. No significant correlations were found with either rearing condition or rh5-HTTLPR genotype. These findings suggest that ontogenetic changes during adolescence in the behavioral response to ethanol differ between rodents and primates. Furthermore, sex differences in the behavioral response to ethanol appear to develop during adolescence. JF - Alcoholism, clinical and experimental research AU - Schwandt, Melanie L AU - Barr, Christina S AU - Suomi, Stephen J AU - Higley, James D AD - Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, NIH Animal Center, Poolesville, Maryland 20837-0529, USA. melanies@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 228 EP - 237 VL - 31 IS - 2 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Serotonin Plasma Membrane Transport Proteins KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Regression Analysis KW - Animals KW - Sex Characteristics KW - Dose-Response Relationship, Drug KW - Alcohol-Related Disorders -- physiopathology KW - Ataxia -- physiopathology KW - Genotype KW - Behavior, Animal -- drug effects KW - Alcohol-Related Disorders -- genetics KW - Movement -- physiology KW - Behavior, Animal -- physiology KW - Alcohol-Related Disorders -- etiology KW - Rodentia KW - Serotonin Plasma Membrane Transport Proteins -- genetics KW - Serotonin Plasma Membrane Transport Proteins -- physiology KW - Female KW - Male KW - Movement -- drug effects KW - Aging -- physiology KW - Central Nervous System Depressants -- pharmacology KW - Alcoholic Intoxication -- physiopathology KW - Ethanol -- pharmacology KW - Macaca mulatta -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68939815?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Age-dependent+variation+in+behavior+following+acute+ethanol+administration+in+male+and+female+adolescent+rhesus+macaques+%28Macaca+mulatta%29.&rft.au=Schwandt%2C+Melanie+L%3BBarr%2C+Christina+S%3BSuomi%2C+Stephen+J%3BHigley%2C+James+D&rft.aulast=Schwandt&rft.aufirst=Melanie&rft.date=2007-02-01&rft.volume=31&rft.issue=2&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-08 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Receiver operating characteristic curve inference from a sample with a limit of detection. AN - 68934927; 17110640 AB - The receiver operating characteristic curve is a commonly used tool for evaluating biomarker usefulness in clinical diagnosis of disease. Frequently, biomarkers being assessed have immeasurable or unreportable samples below some limit of detection. Ignoring observations below the limit of detection leads to negatively biased estimates of the area under the curve. Several correction methods are suggested in the areas of mean estimation and testing but nothing regarding the receiver operating characteristic curve or its summary measures. In this paper, the authors show that replacement values below the limit of detection, including those suggested, result in the same biased area under the curve when properly accounted for, but they also provide guidance on the usefulness of these values in limited situations. The authors demonstrate maximum likelihood techniques leading to asymptotically unbiased estimators of the area under the curve for both normally and gamma distributed biomarker levels. Confidence intervals are proposed, the coverage probability of which is scrutinized by simulation study. An example using polychlorinated biphenyl levels to classify women with and without endometriosis illustrates the potential benefits of these methods. JF - American journal of epidemiology AU - Perkins, Neil J AU - Schisterman, Enrique F AU - Vexler, Albert AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 325 EP - 333 VL - 165 IS - 3 SN - 0002-9262, 0002-9262 KW - Biomarkers KW - 0 KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - Sensitivity and Specificity KW - Endometriosis -- classification KW - Endometriosis -- chemically induced KW - Polychlorinated Biphenyls -- toxicity KW - Humans KW - Polychlorinated Biphenyls -- blood KW - Case-Control Studies KW - Likelihood Functions KW - Female KW - ROC Curve KW - Biomarkers -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Receiver+operating+characteristic+curve+inference+from+a+sample+with+a+limit+of+detection.&rft.au=Perkins%2C+Neil+J%3BSchisterman%2C+Enrique+F%3BVexler%2C+Albert&rft.aulast=Perkins&rft.aufirst=Neil&rft.date=2007-02-01&rft.volume=165&rft.issue=3&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Agreement between contemporaneously recorded and subsequently recalled time spent outdoors: implications for environmental exposure studies. AN - 68934682; 16882464 AB - The aim of the study is to evaluate the agreement between contemporaneously recorded and subsequently recalled time spent outdoors during 1 week among members of an occupational cohort. One hundred twenty-five radiologic technologists from northern and southern geographic areas in the United States recorded time spent outdoors for 7 consecutive days in a daily diary. Six months later, study participants completed a mailed self-administered questionnaire of the number of outdoor hours during the same 7-day period. We tested the agreement between questionnaire responses and diary entries. Logistic regression models were used to identify variables significantly affecting agreement. Time spent outdoors comprised one fifth of the total time recorded in the diaries. Agreement (weighted kappa [kappa(w)]) between reported outdoor time during weekdays (kappa(w) = 0.49; 95% confidence interval [CI], 0.39-0.59) was significantly (p < 0.05) higher than for weekends (kappa(w) = 0.23; 95% CI, 0.12-0.34). Similarly, agreement was lower for weekends compared with weekdays in multivariate analyses, reaching statistical significance (p = 0.05) in only the southern regions. Although our investigation was carried out among volunteers from the US radiologic technologist cohort, we believe retrospective questionnaires may be more accurate in reporting time spent outdoors for weekdays compared with weekends in any group of indoor workers. These differences have implications for the wording in future questionnaires about time spent outdoors and level and sources of uncertainty characterizing estimated time spent outdoors on weekdays versus weekend days. JF - Annals of epidemiology AU - Chodick, Gabriel AU - Freedman, Michal D AU - Kwok, Richard K AU - Fears, Thomas R AU - Linet, Martha S AU - Alexander, Bruce H AU - Kleinerman, Ruth A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health/DHHS, 6120 Executive Boulevard, Rockville, MD 20852, USA. chodick@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 106 EP - 111 VL - 17 IS - 2 SN - 1047-2797, 1047-2797 KW - Index Medicus KW - Minnesota KW - Humans KW - North Carolina KW - Adult KW - Surveys and Questionnaires KW - Retrospective Studies KW - Middle Aged KW - Georgia KW - Male KW - Female KW - Leisure Activities KW - Environmental Exposure KW - Sunlight KW - Mental Recall UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+epidemiology&rft.atitle=Agreement+between+contemporaneously+recorded+and+subsequently+recalled+time+spent+outdoors%3A+implications+for+environmental+exposure+studies.&rft.au=Chodick%2C+Gabriel%3BFreedman%2C+Michal+D%3BKwok%2C+Richard+K%3BFears%2C+Thomas+R%3BLinet%2C+Martha+S%3BAlexander%2C+Bruce+H%3BKleinerman%2C+Ruth+A&rft.aulast=Chodick&rft.aufirst=Gabriel&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=106&rft.isbn=&rft.btitle=&rft.title=Annals+of+epidemiology&rft.issn=10472797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Distribution of the 5-HT(1A) receptor antagonist [ (18)F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia. AN - 68934215; 17021813 AB - To determine whether brain and plasma equilibrium of a proposed PET tracer for 5-HT(1A), [(18)F]FPWAY, can be achieved in a sufficiently short time for practical use of the brain to plasma equilibrium distribution ratio (DR) to monitor receptor availability with and without isoflurane anesthesia. Awake (n=4) and isoflurane-anesthetized (n=4) rats were administered a continuous 60 min intravenous infusion of [(18)F]FPWAY with timed arterial blood sampling. Brains of the isoflurane-anesthetized rats were scanned with the ATLAS small animal PET scanner; awake rats were not. All rats were killed at 60 min and scanned postmortem for 15 min, followed by brain slicing for autoradiography. Several regions of interest (ROIs) were defined in the PET images as well as in the autoradiographic images. Regional DRs were calculated as total activity in the brain ROI divided by plasma [(18)F]FPWAY activity. DRs in the anesthetized animals were constant between 30 and 60 min, indicating that near equilibrium between brain and plasma had been achieved by approximately 30 min. DRs determined from postmortem PET data were higher in the isoflurane-anesthetized rats by 24% (not significant) and 33% (p=0.065) in whole brain and hippocampus, respectively. DRs determined from autoradiographic data were greater in isoflurane-anesthetized rats in medial hippocampus, lateral hippocampus, and cerebellum by 33% (p=0.054), 63% (p<0.01), and 32% (p<0.05), respectively. [(18)F]FPWAY could be an appropriate ligand for monitoring changes in receptor availability in the serotonergic system using a bolus/infusion paradigm. One possible explanation for higher DRs in anesthetized rats may be a reduction in endogenous 5-HT secretion under isoflurane anesthesia. JF - European journal of nuclear medicine and molecular imaging AU - Tokugawa, Joji AU - Ravasi, Laura AU - Nakayama, Toshiyuki AU - Lang, Lixin AU - Schmidt, Kathleen C AU - Seidel, Jurgen AU - Green, Michael V AU - Sokoloff, Louis AU - Eckelman, William C AD - Positron Emission Tomography Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 259 EP - 266 VL - 34 IS - 2 SN - 1619-7070, 1619-7070 KW - 4-fluoro-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyrimidinyl)benzamide KW - 0 KW - Anesthetics, Inhalation KW - Piperazines KW - Pyrimidines KW - Radiopharmaceuticals KW - Serotonin 5-HT1 Receptor Antagonists KW - Isoflurane KW - CYS9AKD70P KW - Index Medicus KW - Rats KW - Radiopharmaceuticals -- pharmacokinetics KW - Animals KW - Rats, Sprague-Dawley KW - Drug Interactions KW - Metabolic Clearance Rate -- drug effects KW - Radiopharmaceuticals -- blood KW - Tissue Distribution -- drug effects KW - Anesthetics, Inhalation -- administration & dosage KW - Male KW - Radionuclide Imaging KW - Piperazines -- pharmacokinetics KW - Brain -- drug effects KW - Brain -- metabolism KW - Pyrimidines -- pharmacokinetics KW - Brain -- diagnostic imaging KW - Isoflurane -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+nuclear+medicine+and+molecular+imaging&rft.atitle=Distribution+of+the+5-HT%281A%29+receptor+antagonist+%5B+%2818%29F%5DFPWAY+in+blood+and+brain+of+the+rat+with+and+without+isoflurane+anesthesia.&rft.au=Tokugawa%2C+Joji%3BRavasi%2C+Laura%3BNakayama%2C+Toshiyuki%3BLang%2C+Lixin%3BSchmidt%2C+Kathleen+C%3BSeidel%2C+Jurgen%3BGreen%2C+Michael+V%3BSokoloff%2C+Louis%3BEckelman%2C+William+C&rft.aulast=Tokugawa&rft.aufirst=Joji&rft.date=2007-02-01&rft.volume=34&rft.issue=2&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=European+journal+of+nuclear+medicine+and+molecular+imaging&rft.issn=16197070&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-06 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Beryllium-induced TNF-alpha production is transcription-dependent in chronic beryllium disease. AN - 68926673; 16980557 AB - Beryllium (Be)-antigen presentation to Be-specific CD4(+) T cells from the lungs of patients with chronic beryllium disease (CBD) results in T cell proliferation and TNF-alpha secretion. We tested the hypothesis that Be-induced, CBD bronchoalveolar lavage (BAL) T cell, transcription-dependent, TNF-alpha secretion was accompanied by specific transcription factor upregulation. After 6 h of Be stimulation, CBD BAL cells produced a median of 883 pg/ml TNF-alpha (range, 608-1,275 pg/ml) versus 198 pg/ml (range, 116-245 pg/ml) by unstimulated cells. After 12 h CBD BAL cells produced a median of 2,963 pg/ml (range, 99-9,424 pg/ml) TNF-alpha versus 55 pg/ml (range, 0-454) by unstimulated cells. Using real-time RT-PCR, Be-stimulated TNF-alpha production at 6 h was preceded by a 5-fold increase in TNF-alpha pre-mRNA copy number:beta-actin copy number (Be median ratio 0.21; unstimulated median ratio 0.04). The median ratio of mature TNF-alpha mRNA:beta-actin mRNA was upregulated 1.4-fold (Be median ratio 0.17; unstimulated median ratio 0.12). Be exposure in the presence of the transcription inhibitor pentoxifylline (PTX) decreased CBD BAL cell TNF-alpha pre-mRNA levels > 60%, whereas treatment with the mRNA splicing inhibitor 2-aminopurine (2AP) decreased levels 40% relative to Be exposure alone. PTX treatment decreased mature TNF-alpha mRNA levels 50% while 2AP decreased levels > 80%, relative to Be exposure alone. Beryllium exposure specifically upregulated transcription factors AP-1 and NF-kappaB. The data suggest that Be exposure induces transcription-dependent TNF-alpha production, potentially due to upregulation of specific transcription factors. JF - American journal of respiratory cell and molecular biology AU - Sawyer, Richard T AU - Fontenot, Andrew P AU - Barnes, Tristan A AU - Parsons, Charles E AU - Tooker, Brian C AU - Maier, Lisa A AU - Gillespie, May M AU - Gottschall, E Brigitte AU - Silveira, Lori AU - Hagman, James AU - Newman, Lee S AD - Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado, USA. sawyerr@niaid.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 191 EP - 200 VL - 36 IS - 2 SN - 1044-1549, 1044-1549 KW - Lipopolysaccharides KW - 0 KW - NF-kappa B KW - Nuclear Proteins KW - RNA Precursors KW - RNA, Messenger KW - Transcription Factor AP-1 KW - Transcription Factors KW - Tumor Necrosis Factor-alpha KW - Beryllium KW - OW5102UV6N KW - Index Medicus KW - RNA Precursors -- metabolism KW - Transcription Factors -- metabolism KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Lipopolysaccharides -- pharmacology KW - CD4-Positive T-Lymphocytes -- immunology KW - Up-Regulation -- genetics KW - Cell Separation KW - RNA, Messenger -- genetics KW - CD4-Positive T-Lymphocytes -- drug effects KW - RNA, Messenger -- metabolism KW - Kinetics KW - Up-Regulation -- drug effects KW - Adult KW - Middle Aged KW - Nuclear Proteins -- metabolism KW - Gene Dosage KW - Bronchoalveolar Lavage Fluid -- cytology KW - Female KW - Male KW - NF-kappa B -- metabolism KW - Transcription, Genetic -- drug effects KW - Tumor Necrosis Factor-alpha -- biosynthesis KW - Tumor Necrosis Factor-alpha -- metabolism KW - Tumor Necrosis Factor-alpha -- genetics KW - Berylliosis -- genetics KW - Beryllium -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68926673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Beryllium-induced+TNF-alpha+production+is+transcription-dependent+in+chronic+beryllium+disease.&rft.au=Sawyer%2C+Richard+T%3BFontenot%2C+Andrew+P%3BBarnes%2C+Tristan+A%3BParsons%2C+Charles+E%3BTooker%2C+Brian+C%3BMaier%2C+Lisa+A%3BGillespie%2C+May+M%3BGottschall%2C+E+Brigitte%3BSilveira%2C+Lori%3BHagman%2C+James%3BNewman%2C+Lee+S&rft.aulast=Sawyer&rft.aufirst=Richard&rft.date=2007-02-01&rft.volume=36&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-28 N1 - Date created - 2007-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Mar 7;143(3):235-47 [10755710] Nat Immunol. 2006 Mar;7(3):311-7 [16462739] Am J Respir Cell Mol Biol. 2004 Jul;31(1):122-30 [14975942] J Biol Chem. 2000 Jun 16;275(24):18432-40 [10748079] Eur Respir J. 2001 Mar;17(3):403-15 [11405518] Am J Respir Crit Care Med. 2001 Oct 1;164(7):1192-9 [11673208] Int Immunopharmacol. 2002 Feb;2(2-3):249-61 [11811929] Am J Respir Crit Care Med. 2002 Mar 15;165(6):788-94 [11897645] Immunity. 2002 Nov;17(5):605-15 [12433367] J Clin Invest. 2002 Nov;110(10):1473-82 [12438445] Eur Respir J. 2002 Nov;20(5):1174-8 [12449171] Clin Chest Med. 2002 Dec;23(4):827-39 [12516537] Immunity. 2003 Jul;19(1):59-70 [12871639] J Clin Invest. 2003 Sep;112(5):776-84 [12952926] Am J Respir Cell Mol Biol. 2004 Oct;31(4):470-7 [15256386] Am Rev Respir Dis. 1978 Dec;118(6 Pt 2):1-120 [742764] Am Rev Respir Dis. 1987 Mar;135(3):696-704 [3826895] Biochem Biophys Res Commun. 1988 Sep 30;155(3):1230-6 [2460096] N Engl J Med. 1989 Apr 27;320(17):1103-9 [2469014] Am Rev Respir Dis. 1989 Jun;139(6):1479-86 [2729754] J Exp Med. 1990 Jul 1;172(1):391-4 [2358784] J Immunol. 1991 Mar 15;146(6):1843-8 [1848573] J Allergy Clin Immunol. 1991 Jul;88(1):54-60 [2071785] Surgery. 1991 Aug;110(2):192-8 [1858029] Science. 1993 Oct 8;262(5131):242-4 [8105536] Am Rev Respir Dis. 1993 Oct;148(4 Pt 1):985-91 [8214955] Annu Rev Cell Biol. 1993;9:317-43 [8280464] Am J Respir Cell Mol Biol. 1994 May;10(5):506-13 [8179912] Mol Cell Biol. 1996 Jun;16(6):2814-22 [8649390] J Immunol. 1997 Jan 1;158(1):518-26 [8977230] Am J Respir Crit Care Med. 1997 Dec;156(6):1884-91 [9412570] J Exp Med. 1998 Jul 20;188(2):247-54 [9670037] J Immunol. 1999 Sep 1;163(5):2747-53 [10453017] J Allergy Clin Immunol. 2005 May;115(5):1036-42 [15867863] J Occup Environ Med. 2005 Dec;47(12):1218-26 [16340702] Toxicology. 2006 Feb 1;218(2-3):216-28 [16314022] Toxicology. 2000 Mar 7;143(3):249-61 [10755711] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeted disruption of Kaposi's sarcoma-associated herpesvirus ORF57 in the viral genome is detrimental for the expression of ORF59, K8alpha, and K8.1 and the production of infectious virus. AN - 68925039; 17108026 AB - Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 regulates viral gene expression at the posttranscriptional level during viral lytic infection. To study its function in the context of the viral genome, we disrupted KSHV ORF57 in the KSHV genome by transposon-based mutagenesis. The insertion of the transposon into the ORF57 exon 2 region also interrupted the 3' untranslated region of KSHV ORF56, which overlaps with the ORF57 coding region. The disrupted viral genome, Bac36-Delta57, did not express ORF57, ORF59, K8alpha, K8.1, or a higher level of polyadenylated nuclear RNA after butyrate induction and could not be induced to produce infectious viruses in the presence of valproic acid, a histone deacetylase inhibitor and a novel KSHV lytic cycle inducer. The ectopic expression of ORF57 partially complemented the replication deficiency of the disrupted KSHV genome and the expression of the lytic gene ORF59. The induced production of infectious virus particles from the disrupted KSHV genome was also substantially restored by the simultaneous expression of both ORF57 and ORF56; complementation by ORF57 alone only partially restored the production of virus, and expression of ORF56 alone showed no effect. Altogether, our data indicate that in the context of the viral genome, KSHV ORF57 is essential for ORF59, K8alpha, and K8.1 expression and infectious virus production. JF - Journal of virology AU - Majerciak, Vladimir AU - Pripuzova, Natalia AU - McCoy, J Philip AU - Gao, Shou-Jiang AU - Zheng, Zhi-Ming AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, NCI/NIH, 10 Center Dr., Rm. 10 S255, MSC-1868, Bethesda, MD 20892-1868, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 1062 EP - 1071 VL - 81 IS - 3 SN - 0022-538X, 0022-538X KW - Glycoproteins KW - 0 KW - K8.1 protein, Human herpesvirus 8 KW - ORF59 protein, Human herpesvirus 8 KW - Viral Proteins KW - Index Medicus KW - Virus Replication KW - Viral Proteins -- genetics KW - Glycoproteins -- metabolism KW - Open Reading Frames KW - Viral Proteins -- metabolism KW - Glycoproteins -- genetics KW - Cell Line KW - Genome, Viral -- drug effects KW - Genome, Viral -- genetics KW - Gene Expression Regulation, Viral -- physiology KW - Herpesvirus 8, Human -- physiology KW - Sarcoma, Kaposi -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Targeted+disruption+of+Kaposi%27s+sarcoma-associated+herpesvirus+ORF57+in+the+viral+genome+is+detrimental+for+the+expression+of+ORF59%2C+K8alpha%2C+and+K8.1+and+the+production+of+infectious+virus.&rft.au=Majerciak%2C+Vladimir%3BPripuzova%2C+Natalia%3BMcCoy%2C+J+Philip%3BGao%2C+Shou-Jiang%3BZheng%2C+Zhi-Ming&rft.aulast=Majerciak&rft.aufirst=Vladimir&rft.date=2007-02-01&rft.volume=81&rft.issue=3&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2000 Jan;74(2):1038-44 [10623771] J Virol. 2003 May;77(10):5578-88 [12719550] AIDS. 2000 May 5;14(7):899-902 [10839602] J Virol. 2000 Dec;74(23):10920-9 [11069986] J Virol. 2001 Feb;75(3):1487-506 [11152521] J Virol. 2001 Mar;75(6):2921-8 [11222717] J Virol. 2001 Apr;75(7):3250-8 [11238851] J Virol. 2001 Aug;75(15):6786-99 [11435557] EMBO J. 2001 Oct 15;20(20):5769-78 [11598019] EMBO J. 2001 Dec 17;20(24):6969-78 [11742974] J Biol Chem. 2002 Apr 26;277(17):14547-56 [11832484] Rev Med Virol. 2003 May-Jun;13(3):173-84 [12740832] N Engl J Med. 1996 May 16;334(20):1292-7 [8609946] Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6641-6 [8692871] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11883-8 [8876232] Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14862-7 [8962146] J Virol. 1997 Jun;71(6):4187-92 [9151804] J Virol. 1998 Jul;72(7):6228-32 [9621095] J Virol. 1998 Aug;72(8):6725-31 [9658120] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10866-71 [9724796] Virology. 1998 Sep 15;249(1):140-9 [9740785] Virology. 1998 Dec 20;252(2):304-12 [9878608] J Virol. 1999 Feb;73(2):1341-9 [9882339] J Virol. 1999 Feb;73(2):1438-46 [9882349] J Virol. 1999 Mar;73(3):1909-17 [9971770] Virology. 1999 Apr 25;257(1):84-94 [10208923] Science. 1999 Apr 23;284(5414):641-4 [10213686] Prog Neurobiol. 1999 May;58(1):31-59 [10321796] J Virol. 1999 Jul;73(7):5556-67 [10364304] J Virol. 1999 Nov;73(11):9348-61 [10516043] J Virol. 2005 Mar;79(6):3479-87 [15731242] Biochem J. 2005 Apr 15;387(Pt 2):295-308 [15537388] Blood. 2005 May 15;105(10):4028-34 [15687238] J Cell Biochem. 2005 Jul 1;95(4):698-711 [15880690] J Virol. 2005 Sep;79(17):10952-67 [16103147] J Clin Pharm Ther. 2005 Oct;30(5):417-21 [16164485] Virology. 2005 Sep 30;340(2):183-91 [16043206] J Virol. 2005 Nov;79(22):14207-21 [16254356] J Pathol. 2006 Jan;208(2):187-98 [16362980] Nat Rev Cancer. 2006 Jan;6(1):38-51 [16397526] J Virol. 2006 Jun;80(11):5251-60 [16699005] J Virol. 2006 Jul;80(14):7037-51 [16809309] J Biol Chem. 2006 Sep 22;281(38):28365-78 [16829516] J Virol. 2006 Dec;80(24):11968-81 [17020939] J Virol. 2003 Sep;77(17):9590-612 [12915572] J Biol Chem. 2003 Sep 26;278(39):37790-8 [12857728] J Virol. 2004 Mar;78(5):2609-14 [14963167] J Virol. 2004 Jun;78(12):6389-98 [15163732] Virology. 2004 Aug 1;325(2):225-40 [15246263] J Biol Chem. 2004 Jul 30;279(31):33001-11 [15155762] J Virol. 2004 Oct;78(20):11121-9 [15452232] Science. 1994 Dec 16;266(5192):1865-9 [7997879] Nat Med. 1996 Mar;2(3):342-6 [8612236] J Virol. 2002 Jun;76(12):6185-96 [12021352] J Virol. 2002 Nov;76(22):11596-604 [12388720] J Virol. 2002 Nov;76(22):11677-87 [12388727] J Virol. 2000 Apr;74(8):3586-97 [10729134] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The ERK mitogen-activated protein kinase pathway contributes to Ebola virus glycoprotein-induced cytotoxicity. AN - 68923678; 17108034 AB - Ebola virus is a highly lethal pathogen that causes hemorrhagic fever in humans and nonhuman primates. Among the seven known viral gene products, the envelope glycoprotein (GP) alone induces cell rounding and detachment that ultimately leads to cell death. Cellular cytoxicity is not seen with comparable levels of expression of a mutant form of GP lacking a mucin-like domain (GPDeltamuc). GP-induced cell death is nonapoptotic and is preceded by downmodulation of cell surface molecules involved in signaling pathways, including certain integrins and epidermal growth factor receptor. To investigate the mechanism of GP-induced cellular toxicity, we analyzed the activation of several signal transduction pathways involved in cell growth and survival. The active form of extracellular signal-regulated kinases types 1 and 2 (ERK1/2), phospho-ERK1/2, was reduced in cells expressing GP compared to those expressing GPDeltamuc as determined by flow cytometry, in contrast to the case for several other signaling proteins. Subsequent analysis of the activation states and kinase activities of related kinases revealed a more pronounced effect on the ERK2 kinase isoform. Disruption of ERK2 activity by a dominant negative ERK or by small interfering RNA-mediated ERK2 knockdown potentiated the decrease in alphaV integrin expression associated with toxicity. Conversely, activation of the pathway through the expression of a constitutively active form of ERK2 significantly protected against this effect. These results indicate that the ERK signaling cascade mediates GP-mediated cytotoxicity and plays a role in pathogenicity induced by this gene product. JF - Journal of virology AU - Zampieri, Carisa A AU - Fortin, Jean-Francois AU - Nolan, Garry P AU - Nabel, Gary J AD - Vaccine Research Center, NIAID, National Institutes of Health, Room 4502, Bldg. 40, MSC-3005, 40 Convent Drive, Bethesda, MD 20892-3005, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 1230 EP - 1240 VL - 81 IS - 3 SN - 0022-538X, 0022-538X KW - Viral Envelope Proteins KW - 0 KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Gene Expression Regulation, Viral KW - Viral Envelope Proteins -- pharmacology KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Ebolavirus -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68923678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=The+ERK+mitogen-activated+protein+kinase+pathway+contributes+to+Ebola+virus+glycoprotein-induced+cytotoxicity.&rft.au=Zampieri%2C+Carisa+A%3BFortin%2C+Jean-Francois%3BNolan%2C+Garry+P%3BNabel%2C+Gary+J&rft.aulast=Zampieri&rft.aufirst=Carisa&rft.date=2007-02-01&rft.volume=81&rft.issue=3&rft.spage=1230&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-06 N1 - Date created - 2007-01-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Virology. 2000 Dec 5;278(1):20-6 [11112476] Eur Cytokine Netw. 2000 Sep;11(3):470-7 [11022134] Nat Cell Biol. 2001 Mar;3(3):301-5 [11231581] J Cell Biol. 2001 Apr 16;153(2):273-82 [11309409] J Virol. 2001 May;75(10):4871-7 [11312358] Virology. 2001 Jul 20;286(1):91-9 [11448162] J Biol Chem. 2001 Oct 19;276(42):38353-60 [11459835] J Virol. 2002 Jan;76(2):817-28 [11752171] Curr Opin Genet Dev. 2002 Feb;12(1):30-5 [11790551] J Virol. 2002 Mar;76(5):2518-28 [11836430] J Virol. 2002 Apr;76(7):3365-73 [11884562] Nat Cell Biol. 2002 Apr;4(4):E65-8 [11944032] J Cell Sci. 2002 Jul 1;115(Pt 13):2781-90 [12077368] EMBO Rep. 2003 Oct;4(10):964-8 [14502223] Genes Cells. 2003 Nov;8(11):847-56 [14622137] J Infect Dis. 2003 Dec 1;188(11):1618-29 [14639531] Oncogene. 2004 Jul 1;23(30):5227-41 [15122343] Anal Biochem. 1976 May 7;72:248-54 [942051] Intervirology. 1982;18(1-2):24-32 [7118520] Semin Cancer Biol. 1994 Aug;5(4):261-8 [7803762] Science. 1998 Feb 13;279(5353):1034-7 [9461435] J Cell Biol. 1998 Mar 9;140(5):1255-63 [9490736] J Virol. 1998 Apr;72(4):3155-60 [9525641] Proc Natl Acad Sci U S A. 1998 May 12;95(10):5762-7 [9576958] J Virol. 1998 Nov;72(11):9173-80 [9765464] Oncogene. 1998 Sep 10;17(10):1271-7 [9771970] Curr Biol. 1998 Oct 22;8(21):1141-50 [9799732] Curr Top Microbiol Immunol. 1999;235:145-73 [9893383] Curr Opin Cell Biol. 1999 Apr;11(2):197-202 [10209147] Immunology. 1999 Apr;96(4):524-8 [10233737] Science. 1999 Aug 13;285(5430):1028-32 [10446041] Mol Biol Cell. 1999 Oct;10(10):3197-204 [10512860] J Virol. 2005 Jan;79(1):547-53 [15596847] J Gen Virol. 2005 Apr;86(Pt 4):1027-33 [15784896] J Virol. 2005 Sep;79(17):11366-81 [16103188] Nat Cell Biol. 2005 Sep;7(9):901-8 [16113676] Immunity. 2005 Oct;23(4):431-43 [16226508] Growth Factors. 2006 Mar;24(1):21-44 [16393692] J Gen Virol. 2006 May;87(Pt 5):1247-57 [16603527] Nat Cell Biol. 2006 May;8(5):432-3 [16691207] Cell Cycle. 2006 Oct;5(19):2179-82 [16969102] J Biol. 2006;5(5):14 [16805921] Science. 1999 Nov 12;286(5443):1374-7 [10558995] Mol Cell Biol. 2000 Mar;20(6):2218-27 [10688668] J Virol. 2000 May;74(10):4933-7 [10775638] Nat Med. 2000 Aug;6(8):886-9 [10932225] J Gen Virol. 2000 Sep;81(Pt 9):2155-9 [10950971] Curr Opin Genet Dev. 2001 Feb;11(1):48-53 [11163150] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells. AN - 68377010; 17075824 AB - Lethal prostate cancers often become androgen-independent due to androgen receptor (AR) overexpression. The role of cadmium in prostate tumor progression was determined. Control and cadmium-transformed prostate epithelial cells (CTPE) were compared for steroid-induced proliferation, steroid receptor expression, and androgen metabolism. CTPE cells showed rapid proliferation in complete medium and sustained proliferation in steroid-reduced medium. Androgens stimulated significantly less cell proliferation and AR-related genes expression in CTPE cells. 5alpha-Dihydrotestosterone increased PSA expression more effectively in control cells. Flutamide reduced 5alpha-dihydrotestosterone-stimulated growth less effectively in CTPE cells compared to control. CTPE cells showed decreased p27 expression. Estrogen receptors were overexpressed and estradiol markedly stimulated proliferation in CTPE cells. In CTPE cells 5alpha-aromatase was markedly increased, while 5alpha-reductase was decreased. Cadmium-induced malignant transformation stimulates androgen independence, unrelated to AR expression or activity. Increased estrogen receptor and 5alpha-aromatase expression suggest estrogen signaling may be critical to this process. (c) 2006 Wiley-Liss, Inc. JF - The Prostate AU - Benbrahim-Tallaa, Lamia AU - Liu, Jie AU - Webber, Mukta M AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 135 EP - 145 VL - 67 IS - 2 SN - 0270-4137, 0270-4137 KW - Androgen Antagonists KW - 0 KW - Androgens KW - Estrogens KW - RNA, Messenger KW - Receptors, Androgen KW - Receptors, Estrogen KW - Cadmium KW - 00BH33GNGH KW - Dihydrotestosterone KW - 08J2K08A3Y KW - Estradiol KW - 4TI98Z838E KW - Flutamide KW - 76W6J0943E KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Prostate -- drug effects KW - Androgen Antagonists -- pharmacology KW - Receptors, Androgen -- genetics KW - Humans KW - Estradiol -- pharmacology KW - Prostate -- metabolism KW - Disease Progression KW - Receptors, Estrogen -- metabolism KW - Receptors, Estrogen -- genetics KW - RNA, Messenger -- metabolism KW - Dihydrotestosterone -- pharmacology KW - Receptors, Androgen -- metabolism KW - Cadmium -- toxicity KW - Flutamide -- pharmacology KW - Gene Expression Regulation -- drug effects KW - Cell Line, Transformed KW - Male KW - Prostatic Neoplasms -- metabolism KW - Epithelial Cells -- metabolism KW - Estrogens -- genetics KW - Epithelial Cells -- drug effects KW - Estrogens -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Prostatic Neoplasms -- chemically induced KW - Cell Transformation, Neoplastic -- drug effects KW - Androgens -- pharmacology KW - Signal Transduction KW - Androgens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68377010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Prostate&rft.atitle=Estrogen+signaling+and+disruption+of+androgen+metabolism+in+acquired+androgen-independence+during+cadmium+carcinogenesis+in+human+prostate+epithelial+cells.&rft.au=Benbrahim-Tallaa%2C+Lamia%3BLiu%2C+Jie%3BWebber%2C+Mukta+M%3BWaalkes%2C+Michael+P&rft.aulast=Benbrahim-Tallaa&rft.aufirst=Lamia&rft.date=2007-02-01&rft.volume=67&rft.issue=2&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=The+Prostate&rft.issn=02704137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chimeric HIV-1 and HIV-2 lentiviral vectors with added safety insurance. AN - 68374458; 17177309 AB - Lentiviruses are unique in their ability to infect both dividing and non-dividing cells. This makes the vectors derived from them particularly useful for gene transfer into non-dividing cells, including stem cells. Lentiviral vectors are becoming the vectors of choice for si/shRNA delivery. The utility of the lentiviral vectors will be enhanced if additional elements of safety are built into their design. One safety concern is the generation of replication competent virus by recombination. We reasoned that HIV-1 and HIV-2 hybrid or chimeric lentiviral vectors will have added safety insurance in this regard. This is based on the premise that HIV-1 and HIV-2 are dissimilar enough in sequence to curtail recombination, yet similar enough to complement functionally. For hybrid vectors, we found that both HIV-1 and HIV-2 transfer vector RNAs could be packaged to equivalent titer by the HIV-1 packaging machinery. However, HIV-2 packaging machinery was unable to package HIV-1 transfer vector as well as it did HIV-2 transfer vector. This non-reciprocacity suggested that the requirement for HIV-2 vectors was more stringent and that for HIV-1 vectors more promiscuous. When the HIV-1 transfer vector was packaged with the chimeric packaging construct where the leader-gag region of HIV-2 was replaced with that of HIV-1 packaging construct, the titer of the vector went up. This suggests that at least some of the determinants of specificity for vector assembly reside in the leader-gag region. Incorporation of central polypurine tract (cPPT) and woodchuck post-transcriptional enhance element (WPRE) into the HIV-2 vectors had only modest effect on vector titer. Thus, chimeric lentiviral vectors with added safety features can be designed without compromising transduction efficiency. JF - Journal of medical virology AU - Sachdeva, Geetanjali AU - D'Costa, Jenice AU - Cho, Jang E AU - Kachapati, Kritika AU - Choudhry, Vidita AU - Arya, Suresh K AD - Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 118 EP - 126 VL - 79 IS - 2 SN - 0146-6615, 0146-6615 KW - Gene Products, gag KW - 0 KW - Index Medicus KW - Virus Replication KW - Virus Assembly KW - Gene Products, gag -- genetics KW - Lentivirus -- metabolism KW - Humans KW - Enhancer Elements, Genetic KW - Lentivirus -- genetics KW - Gene Products, gag -- metabolism KW - Mutagenesis, Insertional KW - Cell Line KW - Genetic Vectors -- standards KW - HIV-1 -- metabolism KW - HIV-1 -- genetics KW - Safety KW - Recombination, Genetic KW - HIV-2 -- genetics KW - HIV-1 -- physiology KW - HIV-2 -- physiology KW - HIV-2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68374458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+medical+virology&rft.atitle=Chimeric+HIV-1+and+HIV-2+lentiviral+vectors+with+added+safety+insurance.&rft.au=Sachdeva%2C+Geetanjali%3BD%27Costa%2C+Jenice%3BCho%2C+Jang+E%3BKachapati%2C+Kritika%3BChoudhry%2C+Vidita%3BArya%2C+Suresh+K&rft.aulast=Sachdeva&rft.aufirst=Geetanjali&rft.date=2007-02-01&rft.volume=79&rft.issue=2&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Journal+of+medical+virology&rft.issn=01466615&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2006-12-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Measuring the rate of gross chromosomal rearrangements in Saccharomyces cerevisiae: A practical approach to study genomic rearrangements observed in cancer. AN - 68373532; 17189859 AB - Gross chromosomal rearrangements (GCRs), including translocations, deletions, amplifications and aneuploidy are frequently observed in various types of human cancers. Despite their clear importance in carcinogenesis, the molecular mechanisms by which GCRs are generated and held in check are poorly understood. By using a GCR assay, which can measure the rate of accumulation of spontaneous GCRs in Saccharomyces cerevisiae, we have found that many proteins involved in DNA replication, DNA repair, DNA recombination, checkpoints, chromosome remodeling, and telomere maintenance, play crucial roles in GCR metabolism. We describe here the theoretical background and practical procedures of this GCR assay. We will explain the breakpoint structure and DNA damage that lead to GCR formation. We will also summarize the pathways that suppress and enhance GCR formation. Finally, we will briefly describe similar assays developed by others and discuss their potential in studying GCR metabolism. JF - Methods (San Diego, Calif.) AU - Motegi, Akira AU - Myung, Kyungjae AD - Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Bethesda, MD 20892, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 168 EP - 176 VL - 41 IS - 2 SN - 1046-2023, 1046-2023 KW - Index Medicus KW - Humans KW - Time Factors KW - Mutation KW - Saccharomyces cerevisiae -- genetics KW - Biological Assay -- methods KW - Chromosomes, Human, Pair 5 -- genetics KW - Chromosome Aberrations KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68373532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+%28San+Diego%2C+Calif.%29&rft.atitle=Measuring+the+rate+of+gross+chromosomal+rearrangements+in+Saccharomyces+cerevisiae%3A+A+practical+approach+to+study+genomic+rearrangements+observed+in+cancer.&rft.au=Motegi%2C+Akira%3BMyung%2C+Kyungjae&rft.aulast=Motegi&rft.aufirst=Akira&rft.date=2007-02-01&rft.volume=41&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Methods+%28San+Diego%2C+Calif.%29&rft.issn=10462023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-01 N1 - Date created - 2006-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Troponin-T and myoglobin plus echocardiographic evaluation for monitoring early cardiotoxicity of weekly epirubicin-paclitaxel in metastatic breast cancer patients. AN - 68369318; 17159609 AB - Increased serum level of troponin-T and myoglobin has been recently reported to be related to cumulative anthracycline exposure. Left ventricular ejection fraction seems accurate in monitoring systolic function according to the latest version of Toxicity Criteria by chemotherapeutics 3.0. From January 2002, 20 patients with untreated advanced breast cancer received epirubicin (25 mg/m/week) and paclitaxel (80 mg/m/week) for 24 weeks. Troponin-T, myoglobin and biochemical serum enzymes circulating levels were measured immediately before and 4 h after epirubicin administration every week. Patients underwent electrocardiography and echocardiography at weeks 0, 8, 16 and 24. The number of courses administered was 352 (median 18, range 4-24). Epirubicin median dose administered was 600 mg/m and paclitaxel median dose administered was 1760 mg/m. Troponin-T never overcame the upper normal limit; one patient experienced troponin-T elevation without any clinical or instrumental sign of cardiac failure. Myoglobin never significantly increased with the exception of a patient who underwent several abdominal fluid drainages. Creatine kinase MB and C-reactive protein never moved outside the upper normal limit. No symptomatic cardiac event was recorded. In 55 performed echocardiograms at weeks 0, 8, 16 and 24, neither left ventricular ejection fraction nor early peak flow/atrial flow velocity registered any significant decrease. No troponin-T or myoglobin serum elevations and Left ventricular ejection fraction/early peak flow/atrial flow velocity changes were registered in our series of nonsymptomatic women during epirubicin/paclitaxel weekly chemotherapy in the absence of clinical cardiac toxicity. Longer follow-up is needed, however, to understand whether the troponin-T or myoglobin circulating level measurement is able to detect subclinical, early-stage doxorubicin-induced cardiotoxicity. JF - Anti-cancer drugs AU - Nisticò, Cecilia AU - Bria, Emilio AU - Cuppone, Federica AU - Carpino, Armando AU - Ferretti, Gianluigi AU - Vitelli, Gaetano AU - Sperduti, Isabella AU - Calabretta, Francesca AU - Toglia, Giuseppe AU - Tomao, Silverio AU - Cognetti, Francesco AU - Terzoli, Edmondo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 227 EP - 232 VL - 18 IS - 2 SN - 0959-4973, 0959-4973 KW - Antibiotics, Antineoplastic KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Myoglobin KW - Troponin T KW - Epirubicin KW - 3Z8479ZZ5X KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Antibiotics, Antineoplastic -- administration & dosage KW - Humans KW - Genes, erbB-2 -- genetics KW - Aged KW - Middle Aged KW - Monitoring, Physiologic KW - Epirubicin -- administration & dosage KW - Stroke Volume -- drug effects KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Female KW - Breast Neoplasms -- drug therapy KW - Troponin T -- blood KW - Cardiovascular Diseases -- blood KW - Echocardiography KW - Cardiovascular Diseases -- chemically induced KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Myoglobin -- blood KW - Breast Neoplasms -- complications KW - Cardiovascular Diseases -- diagnostic imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68369318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Troponin-T+and+myoglobin+plus+echocardiographic+evaluation+for+monitoring+early+cardiotoxicity+of+weekly+epirubicin-paclitaxel+in+metastatic+breast+cancer+patients.&rft.au=Nistic%C3%B2%2C+Cecilia%3BBria%2C+Emilio%3BCuppone%2C+Federica%3BCarpino%2C+Armando%3BFerretti%2C+Gianluigi%3BVitelli%2C+Gaetano%3BSperduti%2C+Isabella%3BCalabretta%2C+Francesca%3BToglia%2C+Giuseppe%3BTomao%2C+Silverio%3BCognetti%2C+Francesco%3BTerzoli%2C+Edmondo&rft.aulast=Nistic%C3%B2&rft.aufirst=Cecilia&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=227&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Risk factors for intrahepatic cholangiocarcinoma in a low-risk population: a nationwide case-control study. AN - 68368682; 17109384 AB - Recently, the incidence of intrahepatic cholangiocarcinoma (ICC) has been increasing in a number of developed (Western) countries. However, risk factors in these low-risk populations are poorly understood. In this nationwide population based case-control study in Denmark, we examined the relationship between selected medical conditions and subsequent ICC risk to provide additional clues to etiopathogenesis. All histologically confirmed ICC cases diagnosed in Denmark between 1978 and 1991 were identified from the Danish cancer registry. Population controls were selected from the central population registry and were matched 4:1 to cases on sex and year of birth. Cases and controls were linked to the Danish hospital discharge registry to obtain information on prior hospital diagnoses. Odds ratios (OR) and 95% confidence intervals (95% CI) were derived using conditional logistic regression. A total of 764 ICC cases and 3,056 population controls were included in the study. Chronic liver diseases were significantly related to ICC: alcoholic liver disease (OR = 19.22, 95% CI = 5.55-66.54), unspecified cirrhosis (OR = 75.9, 95% CI 10.2-565.7). Bile duct diseases were also associated with risk: cholangitis (OR = 6.3, 95% CI = 2.3-17.5), choledocholithiasis (OR = 23.97, 95% CI = 2.9-198.9), cholecystolithiasis (OR = 4.0, 95% CI = 2.0-7.99), though gallbladder removal did not change risk (OR = 1.6, 95% CI = 0.65-3.7). Among other conditions, chronic inflammatory bowel disease (OR = 4.7, 95% CI = 1.65-13.9) was significantly associated with ICC. Diabetes was associated with risk in the year prior to diagnosis of ICC (OR = 3.02, 95% CI = 1.05-8.69). Obesity was unrelated to risk. These results confirm that prior bile duct diseases increase risk of ICC and suggest that alcoholic liver disease and diabetes may also increase risk. JF - International journal of cancer AU - Welzel, Tania M AU - Mellemkjaer, Lene AU - Gloria, Gridley AU - Sakoda, Lori C AU - Hsing, Ann W AU - El Ghormli, Laure AU - Olsen, Jorgen H AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7234, USA. welzlt@mail.nih.gov Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 638 EP - 641 VL - 120 IS - 3 SN - 0020-7136, 0020-7136 KW - Index Medicus KW - Choledocholithiasis -- complications KW - Odds Ratio KW - Registries -- statistics & numerical data KW - Humans KW - Aged KW - Cholecystolithiasis -- complications KW - Liver Cirrhosis -- complications KW - Cholangitis -- complications KW - Inflammatory Bowel Diseases -- complications KW - Logistic Models KW - Risk Factors KW - Case-Control Studies KW - Denmark -- epidemiology KW - Incidence KW - Middle Aged KW - Liver Diseases, Alcoholic -- complications KW - Male KW - Female KW - Bile Duct Neoplasms -- epidemiology KW - Liver Diseases -- complications KW - Bile Ducts, Intrahepatic KW - Cholangiocarcinoma -- etiology KW - Cholangiocarcinoma -- epidemiology KW - Bile Duct Neoplasms -- etiology KW - Bile Duct Diseases -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368682?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Risk+factors+for+intrahepatic+cholangiocarcinoma+in+a+low-risk+population%3A+a+nationwide+case-control+study.&rft.au=Welzel%2C+Tania+M%3BMellemkjaer%2C+Lene%3BGloria%2C+Gridley%3BSakoda%2C+Lori+C%3BHsing%2C+Ann+W%3BEl+Ghormli%2C+Laure%3BOlsen%2C+Jorgen+H%3BMcGlynn%2C+Katherine+A&rft.aulast=Welzel&rft.aufirst=Tania&rft.date=2007-02-01&rft.volume=120&rft.issue=3&rft.spage=638&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer. AN - 68366223; 16933153 AB - Twelve patients with metastatic breast cancer previously exposed to taxanes were treated on a Phase II trial with ixabepilone. Eligible patients had histologically confirmed metastatic breast cancer with measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST), and adequate hematopoietic, renal, and hepatic function. Ixabepilone 8 mg/m(2)/day was given intravenously daily for 3 days for the first 3-week cycle and increased to 10 mg/m(2)/day for subsequent cycles if patients did not have hematologic or other toxicity after the first cycle. Patients continued treatment until progressive disease or unacceptable toxicity. Three, 29, and 33 of 65 cycles administered were at the 7 mg/m(2), 8 mg/m(2) and 10 mg/m(2) dose levels respectively. Grade 4 leukopenia (n=1), grade 3 neutropenia (n=2), grade 2 neuropathy (n=3), and grade 2 transaminase elevation (n=2) were the most notable toxicities. Ten patients had stable disease for at least 6 weeks. No complete or partial responses were observed in 12 evaluable patients treated with ixabepilone daily for 3 days. Although ixabepilone was well-tolerated, the dose of 8-10 mg/m(2) daily for 3 days is not an effective therapy in metastatic breast cancer previously exposed to taxanes. JF - Investigational new drugs AU - Denduluri, Neelima AU - Lee, James J AU - Walshe, Janice AU - Berman, Arlene W AU - Vatas, Ujala AU - Chow, Catherine K AU - Steinberg, Seth M AU - Cox, Michael C AU - Low, Jennifer A AU - Swain, Sandra M AD - Breast Cancer Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Heath, Bldg 8, Rm 5101, 8901 Wisconsin Ave, Bethesda, MD 20889-5015, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 63 EP - 67 VL - 25 IS - 1 SN - 0167-6997, 0167-6997 KW - Epothilones KW - 0 KW - Tubulin Modulators KW - Transaminases KW - EC 2.6.1.- KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - ixabepilone KW - K27005NP0A KW - epothilone B KW - UEC0H0URSE KW - Index Medicus KW - Drug Administration Schedule KW - Injections, Intravenous KW - Humans KW - Disease Progression KW - Peripheral Nervous System Diseases -- chemically induced KW - Tubulin Modulators -- administration & dosage KW - Transaminases -- blood KW - Aspartate Aminotransferases -- blood KW - Hematologic Diseases -- chemically induced KW - Tubulin Modulators -- adverse effects KW - Adult KW - Tubulin Modulators -- therapeutic use KW - Treatment Outcome KW - Neoplasm Metastasis KW - Middle Aged KW - Time Factors KW - Female KW - Breast Neoplasms -- drug therapy KW - Epothilones -- therapeutic use KW - Breast Neoplasms -- pathology KW - Epothilones -- adverse effects KW - Breast Neoplasms -- blood KW - Epothilones -- chemistry KW - Epothilones -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68366223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+new+drugs&rft.atitle=Phase+II+trial+of+ixabepilone%2C+an+epothilone+B+analog%2C+given+daily+for+three+days+every+three+weeks%2C+in+metastatic+breast+cancer.&rft.au=Denduluri%2C+Neelima%3BLee%2C+James+J%3BWalshe%2C+Janice%3BBerman%2C+Arlene+W%3BVatas%2C+Ujala%3BChow%2C+Catherine+K%3BSteinberg%2C+Seth+M%3BCox%2C+Michael+C%3BLow%2C+Jennifer+A%3BSwain%2C+Sandra+M&rft.aulast=Denduluri&rft.aufirst=Neelima&rft.date=2007-02-01&rft.volume=25&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Investigational+new+drugs&rft.issn=01676997&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. AN - 68365804; 17096337 AB - Organochlorine (OC) insecticides have been regulated as possible human carcinogens primarily on the basis of animal studies. However, the epidemiologic evidence is inconsistent. We investigated the relationship between cancer incidence and OC insecticide use among pesticide applicators enrolled in the Agricultural Health Study, a prospective cohort study of 57,311 licensed applicators in Iowa and North Carolina enrolled between 1993 and 1997. Information on ever use of 7 OC insecticides (aldrin, chlordane, DDT, dieldrin, heptachlor, lindane, toxaphene) was collected from a self-administered questionnaire at enrollment. Lifetime exposure-days to OC insecticides were calculated using additional data from a take-home questionnaire completed by 25,291 participants (44% of total). We found no clear evidence of an association between use of OC insecticides and incident cancers (N = 1,150) ascertained through December, 2002. When we focused on individual insecticides and structurally similar groups (aldrin and dieldrin; chlordane and heptachlor), significantly increased relative risks of some cancers were observed for use of some chemicals (rectal cancer and chlordane, lung cancer and dieldrin, non-Hodgkin lymphoma (NHL) and lindane, melanoma and toxaphene, leukemia and chlordane/heptachlor). Some significant decreased relative risks were also observed (colon cancer and aldrin; overall cancer and heptachlor). In conclusion, we did not observe any clear relationship between cancer risk and the use of OC insecticides. Our chemical-specific findings are based on small numbers and multiple comparisons, and should be interpreted with caution; however, some observed associations (lindane and NHL, chlordane/heptachlor and leukemia) are supported by previous evidence. JF - International journal of cancer AU - Purdue, Mark P AU - Hoppin, Jane A AU - Blair, Aaron AU - Dosemeci, Mustafa AU - Alavanja, Michael C R AD - Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. purduem@mail.nih.gov Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 642 EP - 649 VL - 120 IS - 3 SN - 0020-7136, 0020-7136 KW - Hydrocarbons, Chlorinated KW - 0 KW - Insecticides KW - Chlordan KW - 12789-03-6 KW - Heptachlor KW - 7GLS9ACN3L KW - Dieldrin KW - I0246D2ZS0 KW - Aldrin KW - OZE3CLY605 KW - Index Medicus KW - Heptachlor -- poisoning KW - Humans KW - Aged KW - North Carolina -- epidemiology KW - Environmental Pollution -- adverse effects KW - Prospective Studies KW - Aldrin -- poisoning KW - Chlordan -- poisoning KW - Adult KW - Surveys and Questionnaires KW - Dieldrin -- poisoning KW - Incidence KW - Middle Aged KW - Male KW - Environmental Pollution -- analysis KW - Female KW - Iowa -- epidemiology KW - Insecticides -- poisoning KW - Hydrocarbons, Chlorinated -- poisoning KW - Agricultural Workers' Diseases -- etiology KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Occupational Exposure -- analysis KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68365804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Occupational+exposure+to+organochlorine+insecticides+and+cancer+incidence+in+the+Agricultural+Health+Study.&rft.au=Purdue%2C+Mark+P%3BHoppin%2C+Jane+A%3BBlair%2C+Aaron%3BDosemeci%2C+Mustafa%3BAlavanja%2C+Michael+C+R&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-02-01&rft.volume=120&rft.issue=3&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):199-205 [10698482] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1155-63 [11700263] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Int J Occup Med Environ Health. 2001;14(4):339-47 [11885917] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] CA Cancer J Clin. 2002 Sep-Oct;52(5):301-9 [12363327] Environ Health Perspect. 2003 Feb;111(2):179-83 [12573902] Am J Epidemiol. 2003 Apr 15;157(8):683-91 [12697572] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] J Natl Cancer Inst. 1992 May 20;84(10):764-71 [1573662] Int J Cancer. 1993 Mar 12;53(5):740-5 [8449597] Cancer Causes Control. 1994 Sep;5(5):449-57 [7999967] Nature. 1995 Jun 15;375(6532):581-5 [7791873] Environ Health Perspect. 1995 Oct;103 Suppl 7:113-22 [8593856] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Int J Epidemiol. 1996 Dec;25(6):1117-24 [9027514] Am J Ind Med. 1997 Feb;31(2):233-42 [9028440] Occup Environ Med. 1997 Oct;54(10):702-7 [9404316] Am J Ind Med. 1998 Jan;33(1):82-7 [9408531] Cancer Causes Control. 1997 May;8(3):420-43 [9498903] Crit Rev Toxicol. 1998 Mar;28(2):109-227 [9557209] Cancer Causes Control. 1998 May;9(3):311-9 [9684711] Toxicology. 1998 Jun 26;128(1):17-23 [9704902] Environ Res. 2005 May;98(1):104-13 [15721890] Cancer Res. 2005 Oct 15;65(20):9588-94 [16230425] J Occup Environ Med. 2003 Jul;45(7):692-702 [12855910] Toxicol Ind Health. 2002 Mar;18(2):63-70 [12868794] Chemosphere. 2004 Mar;54(10):1509-20 [14659953] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Tsitol Genet. 1974 Jan-Feb;8(1):24-7 [4829676] J Hered. 1976 Sep-Oct;67(5):303-7 [1010933] Scand J Work Environ Health. 1978 Jun;4(2):137-50 [278225] Int Arch Occup Environ Health. 1985;56(2):75-9 [4055072] Scand J Work Environ Health. 1985 Dec;11(6):397-407 [3912986] Teratog Carcinog Mutagen. 1987;7(6):527-40 [2893466] IARC Monogr Eval Carcinog Risks Hum Suppl. 1987;7:1-440 [3482203] Hum Genet. 1989 Oct;83(3):271-3 [2477324] Cancer. 1989 Dec 1;64(11):2381-6 [2804930] Int J Epidemiol. 1989 Dec;18(4):768-74 [2621012] Toxicology. 1991;70(3):283-92 [1771636] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics. AN - 68365310; 17159598 AB - A great deal of effort has been spent in defining the pharmacokinetics and pharmacodynamics of investigational and registered anticancer agents. Often, there is a marked variability in drug handling between individual patients, which contributes to variability in the pharmacodynamic effects of a given dose of a drug. A combination of physiological variables, genetic characteristics (pharmacogenetics) and environmental factors is known to alter the relationship between the absolute dose and the concentration-time profile in plasma. A variety of strategies are now being evaluated in patients with cancer to improve the therapeutic index of anticancer drugs by implementation of pharmacogenetic imprinting through genotyping or phenotyping individual patients. The efforts have mainly focused on variants in genes encoding the drug-metabolizing enzymes thiopurine S-methyltransferase, dihydropyrimidine dehydrogenase, members of the cytochrome P450 family, including the CYP2B, 2C, 2D and 3A subfamilies, members of the UDP glucuronosyltransferase family, as well as the ATP-binding cassette transporters ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein). Several of these genotyping strategies have been shown to have substantial impact on therapeutic outcome and should eventually lead to improved anticancer chemotherapy. JF - Anti-cancer drugs AU - Deeken, John F AU - Figg, William D AU - Bates, Susan E AU - Sparreboom, Alex AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20895, USA. Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 111 EP - 126 VL - 18 IS - 2 SN - 0959-4973, 0959-4973 KW - Antineoplastic Agents KW - 0 KW - Carrier Proteins KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - Index Medicus KW - Animals KW - Carrier Proteins -- metabolism KW - Cytochrome P-450 Enzyme System -- genetics KW - Humans KW - Carrier Proteins -- genetics KW - Cytochrome P-450 Enzyme System -- metabolism KW - Predictive Value of Tests KW - Neoplasms -- drug therapy KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- therapeutic use KW - Pharmacogenetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68365310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Anti-cancer+drugs&rft.atitle=Toward+individualized+treatment%3A+prediction+of+anticancer+drug+disposition+and+toxicity+with+pharmacogenetics.&rft.au=Deeken%2C+John+F%3BFigg%2C+William+D%3BBates%2C+Susan+E%3BSparreboom%2C+Alex&rft.aulast=Deeken&rft.aufirst=John&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=111&rft.isbn=&rft.btitle=&rft.title=Anti-cancer+drugs&rft.issn=09594973&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Defined by Publication: A Commentary on Health Education and Health Promotion Publication Trends AN - 57196193; 200714265 AB - Comments on Ray M. Merrill et al's "Have the Focus and Sophistication of Research in Health Education Changed?" (2007). Attention is given to quantitative & qualitative research in the field & explanations for the publication growth of quantitative but not qualitative research. References. [Reprinted by permission of Sage Publications Inc., copyright 2007, Society for Public Health Education.] JF - Health Education & Behavior AU - Simons-Morton, Bruce AD - Prevention Research Branch, DESPR, NICHD, NIH, Bethesda, MD Mortonb@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - February 2007 SP - 26 EP - 30 PB - Sage Publications, Thousand Oaks CA VL - 34 IS - 1 SN - 1090-1981, 1090-1981 KW - research design KW - statistical methods KW - surveys KW - Health care KW - Periodicals KW - Health education KW - Statistical analysis KW - Research design KW - Publications KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57196193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Defined+by+Publication%3A+A+Commentary+on+Health+Education+and+Health+Promotion+Publication+Trends&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2007-02-01&rft.volume=34&rft.issue=1&rft.spage=26&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198106288567 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Research design; Statistical analysis; Health education; Health care; Publications; Periodicals DO - http://dx.doi.org/10.1177/1090198106288567 ER - TY - CPAPER T1 - Impairment of Treg-Specific Foxp3 Expression by Virus-Induced Dysregulation of TGF-beta Signaling T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40538048; 4516943 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Grant, Christian W Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Signal transduction KW - Foxp3 protein KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Impairment+of+Treg-Specific+Foxp3+Expression+by+Virus-Induced+Dysregulation+of+TGF-beta+Signaling&rft.au=Grant%2C+Christian+W&rft.aulast=Grant&rft.aufirst=Christian&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tissue Specific Localization of Virus-Induced Regulatory T Cells Correlates with CD8+ T Cell Dysfunction T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40523847; 4516958 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Myers, Lara M Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - CD8 antigen KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Tissue+Specific+Localization+of+Virus-Induced+Regulatory+T+Cells+Correlates+with+CD8%2B+T+Cell+Dysfunction&rft.au=Myers%2C+Lara+M&rft.aulast=Myers&rft.aufirst=Lara&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enabling the CTL Response in the Presence of Virus-Induced Regulatory T Cells T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40523692; 4516968 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Hasenkrug, Kim J Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - Cytotoxicity KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Enabling+the+CTL+Response+in+the+Presence+of+Virus-Induced+Regulatory+T+Cells&rft.au=Hasenkrug%2C+Kim+J&rft.aulast=Hasenkrug&rft.aufirst=Kim&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigen Specificity and Origin of Foxp3+Treg during Parasitic Infections T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40522751; 4516967 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Belkaid, Yasmine Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Infection KW - Antigens KW - Specificity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Antigen+Specificity+and+Origin+of+Foxp3%2BTreg+during+Parasitic+Infections&rft.au=Belkaid%2C+Yasmine&rft.aulast=Belkaid&rft.aufirst=Yasmine&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanisms of Action of T Regulatory Cells In Vivo T2 - 2007 Keystone Symposia on Regulatory T Cells (B3) AN - 40522503; 4516949 JF - 2007 Keystone Symposia on Regulatory T Cells (B3) AU - Shevach, Ethan M Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 KW - Lymphocytes T KW - Immunoregulation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40522503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.atitle=Mechanisms+of+Action+of+T+Regulatory+Cells+In+Vivo&rft.au=Shevach%2C+Ethan+M&rft.aulast=Shevach&rft.aufirst=Ethan&rft.date=2007-02-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Regulatory+T+Cells+%28B3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 9&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Substance use and sexual behaviors among Japanese tourists, students, and temporary workers in Honolulu, Hawaii AN - 36704183; 3444908 AB - A total of 249 Japanese nationals-tourists (n = 107), students (n = 98), and temporary workers (n = 44)-were recruited at the targeted community venues in Honolulu, Hawaii, and completed a structured survey questionnaire. Reported lifetime sexually transmitted diseases, or STDs infection (10% male and 20% female participants), and HIV infection rates (7%, 2 out of 31 persons tested) were high. Male participants were more likely to practice safe sex with female sex workers than with steady and casual female partners both in Japan and Hawaii. More than 80% of the participants reported having had sex under the influence of alcohol. Multivariate analysis revealed that positive attitudes toward drug use and negative attitudes toward condom use were significantly correlated with the frequency of sex under the influence of drugs with steady partners in the past 12 months. Future HIV/STD prevention intervention programs must target Japanese youths who are planning to visit Hawaii or elsewhere abroad, as well as Japanese high-risk groups (e.g., temporary workers in Hawaii), and provide information about HIV/STD prevention in relation to substance use. Reprinted by permission of Guilford Publications Inc., New York City JF - AIDS education and prevention AU - Nemoto, Tooru AU - Iwamoto, Mariko AU - Morris, Anne AU - Yokota, Fumihiko AU - Wada, Kiyoshi AD - University of California, San Francisco ; Tulane University ; National Institute of Mental Health, Japan Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 68 EP - 81 VL - 19 IS - 1 SN - 0899-9546, 0899-9546 KW - Sociology KW - Tourism KW - Japanese KW - Attitudes KW - Sexual behaviour KW - Multivariate analysis KW - Hawaii KW - HIV KW - Students KW - Substance use KW - Sexually transmitted diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36704183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+education+and+prevention&rft.atitle=Substance+use+and+sexual+behaviors+among+Japanese+tourists%2C+students%2C+and+temporary+workers+in+Honolulu%2C+Hawaii&rft.au=Nemoto%2C+Tooru%3BIwamoto%2C+Mariko%3BMorris%2C+Anne%3BYokota%2C+Fumihiko%3BWada%2C+Kiyoshi&rft.aulast=Nemoto&rft.aufirst=Tooru&rft.date=2007-02-01&rft.volume=19&rft.issue=1&rft.spage=68&rft.isbn=&rft.btitle=&rft.title=AIDS+education+and+prevention&rft.issn=08999546&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12357; 11563 1025 1542 11325 6071; 6946 1335 4424; 12794 7336 3198; 12334 4049; 11581 3617 6220; 5703 3617 6220; 8379 12224 971; 1378 10404; 164 433 293 14 ER - TY - JOUR T1 - Symptom management and self-care for peripheral neuropathy in HIV/AIDS AN - 36664301; 3425050 AB - Peripheral neuropathy is the most common neurological complication in HIV and is often associated with antiretroviral therapy. As part of a larger study on self-care for symptoms in HIV disease, this study analyzed the prevalence and characteristics of peripheral neuropathy in HIV disease, sociodemographic and disease-related correlates and self-care strategies. A convenience sample of 1,217 respondents was recruited from data collection sites in several US cities, Puerto Rico, Colombia and Taiwan. Results of the study indicated that respondents with peripheral neuropathy (n =450) identified 20 self-care behaviors including complementary therapies, use of medications, exercise and rest and/or elevation of extremities. Ratings of frequency and effectiveness were also included. An activities checklist summarized into five categories of self-care behaviors including activities/thoughts, exercise, medications, complementary therapies and substance was used to determine self-care behaviors. Taking a hot bath was the most frequent strategy used by those with peripheral neuropathy (n =292) and received the highest overall rating of effectiveness of any self-management strategies included in this study at 8.1 (scale 1-10). Other self-care strategies to manage this symptom included: staying off the feet (n = 258), rubbing the feet with cream (n = 177), elevating the feet (n = 236), walking (n = 262), prescribed anti-epileptic agent (n = 80), prescribed analgesics (n = 84), over-the-counter medications (n = 123), vitamin B (n = 122), calcium supplements (n = 72), magnesium (n =48), massage (n = 156), acupuncture (n = 43), reflexology (n = 23 and meditation (n = 80). Several behaviors that are often deemed unhealthy were included among the strategies reported to alleviate peripheral neuropathy including use of marijuana (n = 67), cigarette smoking (n = 139), drinking alcohol (n = 81) and street drugs (n = 30). Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Nicholas, P K AU - Kemppainen, J K AU - Canaval, G E AU - Corless, I B AU - Sefcik, E F AU - Nokes, K M AU - Bain, C A AU - Kirksey, K M AU - Eller, L Sanzero AU - Dole, P J AU - Hamilton, M J AU - Coleman, C L AU - Holzemer, W L AU - Reynolds, N R AU - Portillo, C J AU - Bunch, E H AU - Wantland, D J AU - Voss, J AU - Phillips, R AU - Tsai, Y F AU - Mendez, M Rivero AU - Lindgren, T G AU - Davis, S M AU - Gallagher, D M AD - Brigham and Women's Hospital, Boston ; University of North Carolina ; Universidad del Valle ; Texas A&M University ; City University of New York ; University of California ; Ben Taub General Hospital, Houston ; Rutgers University ; Greenwich House, New York City ; University of Pennsylvania ; Ohio State University ; University of Oslo ; National Institutes of Health, Bethesda ; Chang Gung University ; Universidad de Puerto Rico ; Massachusetts General Hospital, Boston ; New England AIDS Education and Training Center, Boston Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 179 EP - 189 VL - 19 IS - 2 SN - 0954-0121, 0954-0121 KW - Sociology KW - Medical sociology KW - AIDS KW - Health KW - Medical treatment KW - Diseases KW - HIV KW - Neurology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36664301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Symptom+management+and+self-care+for+peripheral+neuropathy+in+HIV%2FAIDS&rft.au=Nicholas%2C+P+K%3BKemppainen%2C+J+K%3BCanaval%2C+G+E%3BCorless%2C+I+B%3BSefcik%2C+E+F%3BNokes%2C+K+M%3BBain%2C+C+A%3BKirksey%2C+K+M%3BEller%2C+L+Sanzero%3BDole%2C+P+J%3BHamilton%2C+M+J%3BColeman%2C+C+L%3BHolzemer%2C+W+L%3BReynolds%2C+N+R%3BPortillo%2C+C+J%3BBunch%2C+E+H%3BWantland%2C+D+J%3BVoss%2C+J%3BPhillips%2C+R%3BTsai%2C+Y+F%3BMendez%2C+M+Rivero%3BLindgren%2C+T+G%3BDavis%2C+S+M%3BGallagher%2C+D+M&rft.aulast=Nicholas&rft.aufirst=P&rft.date=2007-02-01&rft.volume=19&rft.issue=2&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120600971083 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7887 12008; 3617 6220; 8635; 7890 5792 10484; 5703 3617 6220; 482 3617 6220; 5772 DO - http://dx.doi.org/10.1080/09540120600971083 ER - TY - JOUR T1 - Innovative approaches to cohort retention in a community-based HIV/STI prevention trial for socially marginalized Peruvian young adults AN - 220283242; 17327244 AB - Background The conduct of longitudinal clinical trials must involve effective strategies to retain study participants in order to ensure internal validity, adequate statistical power and generalizability of results. Purpose In a large trial in Peru, we implemented various retention strategies to maintain high participation rates over time. Methods Novel participant retention strategies were used to follow highly marginalized populations for two years because traditional locator information, such as telephone numbers and official identification (eg, passport, driver's license, the local equivalent of a social security number) were often unreliable or unavailable. These strategies included detailed preliminary ethnographic research to identify the behaviours of key target groups, approaches to develop strong informal bonds between project staff and participants outside of study settings, and methods to enhance positive participant attitudes towards the study. Results The overall study retention rate after two years was 84%, even though only 26% of the study populations supplied complete locator information (telephone, address and the names of two friends). Limitations The retention strategies used were labour intensive and iterative, which could prove difficult to replicate. Conclusions The two-year retention rate in this study was sufficient to maintain required sample sizes. The methods used to maintain contact with the populations were labour intensive, low tech and adequate for these populations and could be used to retain study participants in other marginalized, urban, low-income areas. [PUBLICATION ABSTRACT] JF - Clinical Trials AU - Villacorta, Victoria AU - Kegeles, Susan AU - Galea, Jerome AU - Konda, Kelika A AU - José Pajuelo Cuba AU - Cáceres Palacios, Carlos F AU - Coates, Thomas J Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 32 EP - 41 CY - London PB - Sage Publications Ltd. VL - 4 IS - 1 SN - 17407745 KW - Medical Sciences--Experimental Medicine, Laboratory Technique KW - Clinical trials KW - Human immunodeficiency virus KW - HIV KW - Research methodology KW - Sexually transmitted diseases KW - STD KW - Young adults KW - Socioeconomic factors KW - Peru KW - Age Factors KW - Humans KW - Adult KW - Sample Size KW - Adolescent KW - Male KW - Female KW - Anthropology, Cultural KW - HIV Infections -- prevention & control KW - Clinical Trials as Topic KW - Research Subjects KW - Sexually Transmitted Diseases -- prevention & control KW - Residence Characteristics KW - Patient Selection UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220283242?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Trials&rft.atitle=Innovative+approaches+to+cohort+retention+in+a+community-based+HIV%2FSTI+prevention+trial+for+socially+marginalized+Peruvian+young+adults&rft.au=Villacorta%2C+Victoria%3BKegeles%2C+Susan%3BGalea%2C+Jerome%3BKonda%2C+Kelika+A%3BJos%C3%A9+Pajuelo+Cuba%3BC%C3%A1ceres+Palacios%2C+Carlos+F%3BCoates%2C+Thomas+J&rft.aulast=Villacorta&rft.aufirst=Victoria&rft.date=2007-02-01&rft.volume=4&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Clinical+Trials&rft.issn=17407745&rft_id=info:doi/10.1177%2F1740774506075869 LA - English DB - ProQuest Central N1 - Copyright - SAGE Publications © Feb 2007 N1 - Last updated - 2016-06-25 N1 - SubjectsTermNotLitGenreText - Peru DO - http://dx.doi.org/10.1177/1740774506075869 ER - TY - JOUR T1 - Making the prices of new drugs fairer AN - 21284059; 7286586 JF - British Medical Journal AU - Sotelo, Julio AD - National Institutes of Health of Mexico, Mexico City Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 369 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 334 IS - 7589 SN - 0959-8138, 0959-8138 KW - Biotechnology and Bioengineering Abstracts KW - Drugs KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21284059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Journal&rft.atitle=Making+the+prices+of+new+drugs+fairer&rft.au=Sotelo%2C+Julio&rft.aulast=Sotelo&rft.aufirst=Julio&rft.date=2007-02-01&rft.volume=334&rft.issue=7589&rft.spage=369&rft.isbn=&rft.btitle=&rft.title=British+Medical+Journal&rft.issn=09598138&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Drugs ER - TY - JOUR T1 - Phase II studies of anticancer chemotherapy: indirect evidence of poor quality AN - 21279599; 7286056 JF - Annals of Oncology AU - Ottaiano, A AU - Facchini, G AU - Nasti, G AU - Budillon, A AU - Caraglia, M AD - Clinical Immunology Unit. B Medical Oncology Unit. Experimental Pharmacology Unit, National Cancer Institute Fondazione 'G. Pascale', Naples, Italy Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 403 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 18 IS - 2 SN - 0923-7534, 0923-7534 KW - Biotechnology and Bioengineering Abstracts KW - Chemotherapy KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21279599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Oncology&rft.atitle=Phase+II+studies+of+anticancer+chemotherapy%3A+indirect+evidence+of+poor+quality&rft.au=Ottaiano%2C+A%3BFacchini%2C+G%3BNasti%2C+G%3BBudillon%2C+A%3BCaraglia%2C+M&rft.aulast=Ottaiano&rft.aufirst=A&rft.date=2007-02-01&rft.volume=18&rft.issue=2&rft.spage=403&rft.isbn=&rft.btitle=&rft.title=Annals+of+Oncology&rft.issn=09237534&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Chemotherapy ER - TY - JOUR T1 - A High-Throughput Cell-Based Assay to Identify Specific Inhibitors of Transcription Factor AP-1 AN - 21201307; 11617331 AB - The oncogenic transcription factor AP-1 (activator protein-1) is required for tumor promotion and progression. Identification of novel and specific AP-1 inhibitors would be beneficial for cancer prevention and therapy. The authors have developed a high-throughput assay to screen synthetic and natural product libraries for noncytotoxic inhibitors of mitogen-activated AP-1 activity. The cell-based high-throughput screen is conducted in a 384-well format using a fluorescent resonance energy transfer (FRET) substrate to quantify the activity of a b-lactamase reporter under the control of an AP-1-dependent promoter. The ratiometric FRET readout makes this assay extremely robust and reproducible, particularly for use with natural product extracts. To eliminate false positives due to cell killing, a cytotoxicity assay was incorporated. The AP-1 b-lactamase reporter was validated with inhibitors of kinases located upstream of AP-1 and with known natural product inhibitors of AP-1 (nordihydroguaiaretic acid and curcumin). The assay was able to identify other known AP-1 inhibitors and protein kinase C modulators, as well as a number of chemically diverse compounds with unknown mechanisms of action from natural products libraries. Application to natural product extracts identified hits from a range of taxonomic groups. Screening of synthetic compounds and natural products should identify novel AP-1 inhibitors that may be useful in the prevention and treatment of cancers. JF - Journal of Biomolecular Screening AU - Ruocco, Katie M AU - Goncharova, Ekaterina I AU - Young, Matthew R AU - Colburn, Nancy H AU - McMahon, James B AU - Henrich, Curtis J AD - Laboratory of Cancer Prevention, Gene Regulation Section, National Cancer Institute-Frederick, Frederick, MD Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 133 EP - 139 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 12 IS - 1 SN - 1087-0571, 1087-0571 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - AP-1 KW - high-throughput assay KW - natural products KW - b-lactamase KW - Protein kinase C KW - Curcumin KW - Activator protein 1 KW - Tumorigenesis KW - fluorescence resonance energy transfer KW - Cancer KW - Promoters KW - Cytotoxicity KW - Nordihydroguaiaretic acid KW - Transcription factors KW - b-Lactamase KW - N 14835:Protein-Nucleic Acids Association KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21201307?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=A+High-Throughput+Cell-Based+Assay+to+Identify+Specific+Inhibitors+of+Transcription+Factor+AP-1&rft.au=Ruocco%2C+Katie+M%3BGoncharova%2C+Ekaterina+I%3BYoung%2C+Matthew+R%3BColburn%2C+Nancy+H%3BMcMahon%2C+James+B%3BHenrich%2C+Curtis+J&rft.aulast=Ruocco&rft.aufirst=Katie&rft.date=2007-02-01&rft.volume=12&rft.issue=1&rft.spage=133&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057106296686 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Protein kinase C; Promoters; Cytotoxicity; Curcumin; Nordihydroguaiaretic acid; Transcription factors; Tumorigenesis; Activator protein 1; fluorescence resonance energy transfer; natural products; b-Lactamase; Cancer DO - http://dx.doi.org/10.1177/1087057106296686 ER - TY - JOUR T1 - Nominations for CERHR Expert Panel Evaluations AN - 21058449; 7596891 AB - Abstract not available. JF - Birth Defects Research Part B: Developmental and Reproductive Toxicology AU - Shelby, Michael D AD - Director, CERHR, NIEHS EC-32, P.O. Box 12233, RTP, NC 27709, shelby@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 80 IS - 1 SN - 1542-9733, 1542-9733 KW - Toxicology Abstracts KW - Sensory evaluation KW - Congenital defects KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21058449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.atitle=Nominations+for+CERHR+Expert+Panel+Evaluations&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2007-02-01&rft.volume=80&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Birth+Defects+Research+Part+B%3A+Developmental+and+Reproductive+Toxicology&rft.issn=15429733&rft_id=info:doi/10.1002%2Fbdrb.20097 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Sensory evaluation; Congenital defects DO - http://dx.doi.org/10.1002/bdrb.20097 ER - TY - JOUR T1 - Quantification of alpha 4 beta 2* nicotinic receptors in the rat brain with microPET[registered] and 2-[ super(18)F]F-A-85380 AN - 21057148; 7345935 AB - The radioligand 2-[ super(18)F]F-A-85380 has been used for PET studies of the alpha 4 beta 2* subtype of nicotinic acetylcholine receptors (nAChRs) in the living brain of humans and nonhuman primates. In order to extend the capacity of microPET to quantify neuroreceptors in rat brain, we carried out studies of 2- [ super(18)F]F-A-85380 to measure the apparent binding potential BP* in individual rats, which were studied repeatedly over several months. Using a bolus-plus- infusion paradigm, 2-[ super(18)F]F-A-85380 (specific activity 20-1300 GBq/ mu mol) was administered intravenously over 8 to 9 h with K sub(bol) values of 350 to 440 min and a mean infusion rate of 0.03 +/- 0.01 nmol/kg/h. Studies included a 2-h nicotine infusion initiated 2 h before the end of scanning to displace specifically bound radioactivity. Steady state binding in brain was obtained within 5 h as defined by the occurrence of constant radioactivity concentrations in brain regions and constant, free arterial plasma levels of nonmetabolized radioligand. BP* averages (+/- SEM) for thalamus, forebrain, and cerebellum were 5.9 +/- 0.7, 2.6 +/- 0.4, and 1.0 +/- 0.1, respectively, which are consistent with the alpha 4 beta 2* nAChR distribution in rat brain measured in vitro. Studies of receptor occupancy determined the ED sub(50) to be 0.29 nmol/kg/h. The demonstration that alpha 4 beta 2* nAChRs are quantifiable in the rat brain using PET measurements, coupled with the ability to conduct longitudinal studies over several months in the same rats, suggests potential applications to studies of chronic nicotine use, its treatment, and abnormal functioning of alpha 4 beta 2* receptors in a rat model. JF - NeuroImage AU - Vaupel, DBruce AU - Stein, Elliot A AU - Mukhin, Alexey G Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1352 EP - 1362 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Forebrain KW - Plasma levels KW - Scanning KW - Nicotine KW - Brain KW - Positron emission tomography KW - Cerebellum KW - Radioactivity KW - Primates KW - Acetylcholine receptors (nicotinic) KW - Thalamus KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21057148?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Quantification+of+alpha+4+beta+2*+nicotinic+receptors+in+the+rat+brain+with+microPET%5Bregistered%5D+and+2-%5B+super%2818%29F%5DF-A-85380&rft.au=Vaupel%2C+DBruce%3BStein%2C+Elliot+A%3BMukhin%2C+Alexey+G&rft.aulast=Vaupel&rft.aufirst=DBruce&rft.date=2007-02-01&rft.volume=34&rft.issue=4&rft.spage=1352&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.10.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Forebrain; Plasma levels; Scanning; Nicotine; Cerebellum; Positron emission tomography; Brain; Radioactivity; Thalamus; Acetylcholine receptors (nicotinic); Primates DO - http://dx.doi.org/10.1016/j.neuroimage.2006.10.036 ER - TY - JOUR T1 - Metabolic syndrome in youth: current issues and challenges AN - 21017164; 9280228 JF - Applied Physiology, Nutrition, and Metabolism AU - Huang, Terry T-K AU - Ball, Geoff DC AU - Franks, Paul W AD - Endocrinology, Nutrition and Growth Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, 6100 Executive Boulevard, 4B11, Rockville, MD 20852, USA., huangter@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 13 EP - 22 PB - NRC Research Press VL - 32 IS - 1 SN - 1715-5312, 1715-5312 KW - Physical Education Index KW - Nutrition KW - Youth KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21017164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.atitle=Metabolic+syndrome+in+youth%3A+current+issues+and+challenges&rft.au=Huang%2C+Terry+T-K%3BBall%2C+Geoff+DC%3BFranks%2C+Paul+W&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2007-02-01&rft.volume=32&rft.issue=1&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Applied+Physiology%2C+Nutrition%2C+and+Metabolism&rft.issn=17155312&rft_id=info:doi/10.1139%2FH06-094 LA - English DB - Physical Education Index N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nutrition; Youth DO - http://dx.doi.org/10.1139/H06-094 ER - TY - JOUR T1 - In vivo 13C saturation transfer effect of the lactate dehydrogenase reaction AN - 20860434; 8368381 AB - Lactate dehydrogenase (LDH, EC 1.1.1.27) catalyzes an exchange reaction between pyruvate and lactate. It is demonstrated here that this reaction is sufficiently fast to cause a significant magnetization (saturation) transfer effect when the 13C resonance of pyruvate is saturated by a continuous-wave (CW) RF pulse. Infusion of [2-13C]glucose was used to allow labeling of pyruvate C2 at 207.9 ppm to determine the pseudo first-order rate constant of the unidirectional lactate pyruvate flux in vivo. During systemic administration of GABAA receptor antagonist bicuculline, this pseudo first-order rate constant was determined to be 0.08 - 0.01 s-1 (mean - SD, N = 4) in halothane-anesthetized adult rat brains. In 9L and C6 rat glioma models, the 13C saturation transfer effect of the LDH reaction was also detected in vivo. Our results demonstrate that the 13C magnetization transfer effect of the LDH reaction may be useful as a novel marker for utilizing noninvasive in vivo MRS to study many physiological and pathological conditions, such as cancer. Magn Reson Med 57:258-264, 2007. JF - Magnetic Resonance in Medicine AU - Xu, Su AU - Yang, Jehoon AU - Shen, Jun AD - Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 258 EP - 264 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Brain tumors KW - ^g-Aminobutyric acid A receptors KW - Pyruvic acid KW - Animal models KW - Brain KW - Lactic acid KW - Bicuculline KW - N.M.R. KW - Glioma KW - L-Lactate dehydrogenase KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=In+vivo+13C+saturation+transfer+effect+of+the+lactate+dehydrogenase+reaction&rft.au=Xu%2C+Su%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Xu&rft.aufirst=Su&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21137 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Pyruvic acid; L-Lactate dehydrogenase; Lactic acid; Brain; N.M.R.; Animal models; ^g-Aminobutyric acid A receptors; Glioma; Brain tumors; Bicuculline DO - http://dx.doi.org/10.1002/mrm.21137 ER - TY - JOUR T1 - Novel strategy for cerebral 13C MRS using very low RF power for proton decoupling AN - 20857715; 8368382 AB - One of the major difficulties of in vivo 13C MRS is the need to decouple the large, one-bond, 1H-13C scalar couplings in order to obtain useful signal-to-noise ratios (SNRs) and spectral resolution at magnetic field strengths that are accessible to clinical studies. In this report a new strategy for in vivo cerebral 13C MRS is proposed. We realized that the turnover kinetics of glutamate (Glu) C5 from exogenous [2-13C]glucose (Glc) is identical to that of Glu C4 from exogenous [1-13C]Glc. The carboxylic/amide carbons are only coupled to protons via very weak long-range 1H-13C scalar couplings. As such, they can be effectively decoupled at very low RF power. Therefore, decoupling of the large 1H-13C scalar couplings can be avoided by the use of [2-13C]Glc. An additional advantage of this strategy is the lack of contamination from subcutaneous lipids because there are no overlapping fat signals in the vicinity of the Glu C5 and glutamine (Gln) C5 peaks. The feasibility of this strategy was demonstrated using 13C MRS on rhesus monkey brains at 4.7T. Magn Reson Med 57:265-271, 2007. JF - Magnetic Resonance in Medicine AU - Li, Shizhe AU - Yang, Jehoon AU - Shen, Jun AD - Magnetic Resonance Spectroscopy Core Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA, shenj@intra.nimh.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 265 EP - 271 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Glutamine KW - Contamination KW - Lipids KW - Carbon KW - N.M.R. KW - Macaca mulatta KW - Protons KW - Brain KW - Magnetic fields KW - Kinetics KW - Glutamic acid KW - amides KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20857715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Novel+strategy+for+cerebral+13C+MRS+using+very+low+RF+power+for+proton+decoupling&rft.au=Li%2C+Shizhe%3BYang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Li&rft.aufirst=Shizhe&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=265&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Macaca mulatta; Protons; Lipids; Carbon; Magnetic fields; Glutamic acid; Brain; N.M.R.; amides; Kinetics; Glutamine; Contamination DO - http://dx.doi.org/10.1002/mrm.21148 ER - TY - JOUR T1 - Real-time shimming to compensate for respiration-induced B0 fluctuations AN - 20856695; 8368392 AB - In MRI of human brain, the respiratory cycle can induce B0-field fluctuations through motion of the chest and fluctuations in local oxygen concentration. The associated NMR frequency changes can affect the MRI data in various ways and lead to temporal signal fluctuations, and image artifacts such as ghosting and blurring. Since the size of the effect scales with magnetic field strength, artifacts become particularly problematic at fields above 3.0T. Furthermore, the spatial dependence of the B0-field fluctuations complicates their correction. In this work, a new method is presented that allows compensation of field fluctuations by modulating the B0 shims in real time. In this method, a reference scan is acquired to measure the spatial distribution of the B0 effect related to chest motion. During the actual scan, this information is then used, together with chest motion data, to apply compensating B0 shims in real time. The method can be combined with any type of scan without modifications to the pulse sequence. Real-time B0 shimming is demonstrated to substantially improve the phase stability of EPI data and the image quality of multishot gradient-echo (GRE) MRI at 7T. Magn Reson Med 57:362-368, 2007. JF - Magnetic Resonance in Medicine AU - van Gelderen, P AU - de Zwart, J A AU - Starewicz, P AU - Hinks, R S AU - Duyn, J H AD - Advanced MRI, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA, gelderen@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 362 EP - 368 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Data processing KW - Spatial distribution KW - Magnetic resonance imaging KW - Brain KW - Chest KW - Magnetic fields KW - N.M.R. KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20856695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+shimming+to+compensate+for+respiration-induced+B0+fluctuations&rft.au=van+Gelderen%2C+P%3Bde+Zwart%2C+J+A%3BStarewicz%2C+P%3BHinks%2C+R+S%3BDuyn%2C+J+H&rft.aulast=van+Gelderen&rft.aufirst=P&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=362&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21136 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Data processing; Chest; N.M.R.; Spatial distribution; Magnetic fields; Brain DO - http://dx.doi.org/10.1002/mrm.21136 ER - TY - JOUR T1 - Mechanism of Ad5 Vaccine Immunity and Toxicity: Fiber Shaft Targeting of Dendritic Cells AN - 20806565; 7261518 AB - Recombinant adenoviral (rAd) vectors elicit potent cellular and humoral immune responses and show promise as vaccines for HIV-1, Ebola virus, tuberculosis, malaria, and other infections. These vectors are now widely used and have been generally well tolerated in vaccine and gene therapy clinical trials, with many thousands of people exposed. At the same time, dose-limiting adverse responses have been observed, including transient low-grade fevers and a prior human gene therapy fatality, after systemic high-dose recombinant adenovirus serotype 5 (rAd5) vector administration in a human gene therapy trial. The mechanism responsible for these effects is poorly understood. Here, we define the mechanism by which Ad5 targets immune cells that stimulate adaptive immunity. rAd5 tropism for dendritic cells (DCs) was independent of the coxsackievirus and adenovirus receptor (CAR), its primary receptor or the secondary integrin RGD receptor, and was mediated instead by a heparin-sensitive receptor recognized by a distinct segment of the Ad5 fiber, the shaft. rAd vectors with CAR and RGD mutations did not infect a variety of epithelial and fibroblast cell types but retained their ability to transfect several DC types and stimulated adaptive immune responses in mice. Notably, the pyrogenic response to the administration of rAd5 also localized to the shaft region, suggesting that this interaction elicits both protective immunity and vector- induced fevers. The ability of replication-defective rAd5 viruses to elicit potent immune responses is mediated by a heparin-sensitive receptor that interacts with the Ad5 fiber shaft. Mutant CAR and RGD rAd vectors target several DC and mononuclear subsets and induce both adaptive immunity and toxicity. Understanding of these interactions facilitates the development of vectors that target DCs through alternative receptors that can improve safety while retaining the immunogenicity of rAd vaccines. JF - PLoS Pathogens AU - Cheng, Cheng AU - Gall, Jason GD AU - Kong, Wing-Pui AU - Sheets, Rebecca L AU - Gomez, Phillip L AU - King, CRichter AU - Nabel, Gary J AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases Y1 - 2007/02// PY - 2007 DA - Feb 2007 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 3 IS - 2 SN - 1553-7366, 1553-7366 KW - Toxicology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Serotypes KW - Mycobacterium KW - Ebola virus KW - Malaria KW - Infection KW - Clinical trials KW - Fibroblasts KW - Fever KW - Expression vectors KW - Dendritic cells KW - Integrins KW - Human immunodeficiency virus 1 KW - Tuberculosis KW - Immune response (humoral) KW - Gene therapy KW - Tropism KW - Adenovirus KW - Vectors KW - Toxicity KW - Pathogens KW - Fibers KW - Coxsackievirus KW - Immunogenicity KW - Vaccines KW - Mutation KW - W 30905:Medical Applications KW - K 03350:Immunology KW - X 24310:Pharmaceuticals KW - V 22350:Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20806565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Pathogens&rft.atitle=Mechanism+of+Ad5+Vaccine+Immunity+and+Toxicity%3A+Fiber+Shaft+Targeting+of+Dendritic+Cells&rft.au=Cheng%2C+Cheng%3BGall%2C+Jason+GD%3BKong%2C+Wing-Pui%3BSheets%2C+Rebecca+L%3BGomez%2C+Phillip+L%3BKing%2C+CRichter%3BNabel%2C+Gary+J&rft.aulast=Cheng&rft.aufirst=Cheng&rft.date=2007-02-01&rft.volume=3&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Pathogens&rft.issn=15537366&rft_id=info:doi/10.1371%2Fjournal.ppat.0030025 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Serotypes; Gene therapy; Tropism; Vectors; Malaria; Pathogens; Toxicity; Infection; Clinical trials; Fibroblasts; Expression vectors; Fever; Fibers; Dendritic cells; Integrins; Immunogenicity; Tuberculosis; Vaccines; Immune response (humoral); Mutation; Mycobacterium; Coxsackievirus; Human immunodeficiency virus 1; Adenovirus; Ebola virus DO - http://dx.doi.org/10.1371/journal.ppat.0030025 ER - TY - JOUR T1 - Therapy for Gaucher disease: Don't stop thinking about tomorrow AN - 20806238; 7656531 AB - While enzyme replacement therapy for Gaucher disease has been widely used and appears to be an efficacious and safe treatment, this success should not be a reason for complacency. Other treatment strategies currently under consideration for patients with Gaucher disease include gene therapy, substrate reduction therapy and chaperone therapy. Furthermore, improvements in enzyme therapy could also have a significant clinical impact. Individuals with Gaucher disease and other lysosomal disorders will greatly benefit from continual refinement and optimization of the current therapy, as well as from the development of new treatment modalities that offer improvements in efficacy, cost, safety and availability. JF - Molecular Genetics and Metabolism AU - Sidransky, Ellen AU - Lamarca, Mary E AU - Ginns, Edward I AD - Section on Molecular Neurogenetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Building 35, Room 1A213, 35 Convent Drive, MSC 3708, Bethesda, MD 20892, USA, sidranse@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 122 EP - 125 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 90 IS - 2 SN - 1096-7192, 1096-7192 KW - Biotechnology and Bioengineering Abstracts KW - Gaucher disease KW - Enzyme replacement therapy KW - Lysosomal storage diseases KW - Chaperone therapy KW - Gene therapy KW - Substrate reduction therapy KW - Gaucher's disease KW - Enzymes KW - Chaperones KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20806238?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Genetics+and+Metabolism&rft.atitle=Therapy+for+Gaucher+disease%3A+Don%27t+stop+thinking+about+tomorrow&rft.au=Sidransky%2C+Ellen%3BLamarca%2C+Mary+E%3BGinns%2C+Edward+I&rft.aulast=Sidransky&rft.aufirst=Ellen&rft.date=2007-02-01&rft.volume=90&rft.issue=2&rft.spage=122&rft.isbn=&rft.btitle=&rft.title=Molecular+Genetics+and+Metabolism&rft.issn=10967192&rft_id=info:doi/10.1016%2Fj.ymgme.2006.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene therapy; Gaucher's disease; Enzymes; Chaperones DO - http://dx.doi.org/10.1016/j.ymgme.2006.09.007 ER - TY - JOUR T1 - Secular trends in the association of socio-economic position with self-reported dietary attributes and biomarkers in the US population: National Health and Nutrition Examination Survey (NHANES) 1971-1975 to NHANES 1999-2002 AN - 20699292; 10837806 AB - Recent reports suggest persistence of health disparities related to socio-economic position (SEP). To understand if diet may be a contributor to these trends, we examined secular trends in the association of diet and indicators of SEP from 1971-1975 to 1999-2002. We used data from the National Health and Nutrition Examination Surveys (NHANES) I (1971-1975), II (1976-1980), III (1988-1994) and 1999-2002 to examine the independent associations of poverty income ratio (PIR) and education with diet and biomarkers of diet and disease in 25-74-year-olds (n=36600). We used logistic and linear regression methods to adjust for multiple covariates and survey design to examine these associations. A large PIR differential in the likelihood of reporting a fruit or all five food groups and vitamin C intake, and an education differential in likelihood of obesity and carbohydrate intake, was noted in 1971-1975 but narrowed in 1999-2002 (P<0.007). The positive association of education with intake of a fruit, vegetable or all five food groups, vitamins A and C, calcium and potassium intake remained unchanged across surveys (P<0.001). Similarly, the positive association of PIR with the amount of foods and intakes of energy and potassium remained unchanged over three decades (P<0.001). The education and the PIR differential in energy density, and the PIR differential in the likelihood of obesity, persisted over the period of the four surveys (P<0.001). Persistence of unfavourable dietary and biomarker profiles in Americans with low income and education suggests continued need for improvement in the quality of diets of these high-risk groups. JF - Public Health Nutrition AU - Kant, Ashima K AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, Biostatistics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, ashima.kant@qc.cuny.edu Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 158 EP - 167 PB - Cambridge University Press, 32 Avenue of the Americas New York NY 10013-2473 USA VL - 10 IS - 2 SN - 1368-9800, 1368-9800 KW - Risk Abstracts KW - Calcium KW - obesity KW - Socioeconomics KW - Nutrition KW - vitamins KW - poverty KW - income KW - Carbohydrates KW - Bioindicators KW - Diets KW - fruits KW - Potassium KW - Education KW - USA KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20699292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+Health+Nutrition&rft.atitle=Secular+trends+in+the+association+of+socio-economic+position+with+self-reported+dietary+attributes+and+biomarkers+in+the+US+population%3A+National+Health+and+Nutrition+Examination+Survey+%28NHANES%29+1971-1975+to+NHANES+1999-2002&rft.au=Kant%2C+Ashima+K%3BGraubard%2C+Barry+I&rft.aulast=Kant&rft.aufirst=Ashima&rft.date=2007-02-01&rft.volume=10&rft.issue=2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Public+Health+Nutrition&rft.issn=13689800&rft_id=info:doi/10.1017%2FS1368980007246749 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - USA; Diets; Education; Bioindicators; fruits; Nutrition; income; obesity; Socioeconomics; Potassium; vitamins; poverty; Calcium; Carbohydrates DO - http://dx.doi.org/10.1017/S1368980007246749 ER - TY - JOUR T1 - Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray AN - 20631589; 9360674 AB - The mRNA cap-binding protein, eukaryotic initiation factor 4E (eIF4E), is a rate-limiting factor of cap-dependent translation initiation. When elevated, eIF4E greatly facilitates translation of a selected spectrum of mRNAs coding for proteins critical to angiogenesis and growth such as vascular endothelial growth factor (VEGF) and cyclin D1. Expression levels of eIF4E, VEGF, and cyclin D1 were examined in multi-tumor tissue microarray by immunohistochemistry and analyzed quantitatively. eIF4E, VEGF and cyclin D1 protein were elevated in tumors of the breast (62, 78, or 40%), colon (72, 77, or 12%), glioblastoma multiforme (48, 68, or 52%), lymphoma (66, 74, or 38%), melanoma (59, 73, or 58%), NSCLC (81, 82, or 29%), ovary (50, 39, or 13%), and prostate (78, 97, or 21%), respectively. eIF4E levels were strongly correlated with VEGF and cyclin D1 in melanoma (Spearman's r=0.97 and 0.77; all P0.15). The significant association of eIF4E with VEGF and cyclin D1 in multiple tumors supports a role for eIF4E in translational regulation of proteins related to angiogenesis and growth. JF - Oncology Reports AU - Yang, S X AU - Hewitt, S M AU - Steinberg, S M AU - Liewehr, D J AU - Swain, S M AD - National Clinical Target Validation Laboratory, Division of Cancer Treatment and Diagnosis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA, yangxia@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 281 EP - 287 VL - 17 IS - 2 SN - 1021-335X, 1021-335X KW - Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - Vascular endothelial growth factor KW - Translation KW - Translation initiation KW - glioblastoma multiforme KW - Angiogenesis KW - Tumors KW - Initiation factor eIF-4E KW - Melanoma KW - Colon KW - Lung KW - Ovaries KW - Lymphoma KW - Prostate KW - cap-binding protein KW - Immunohistochemistry KW - cyclin D1 KW - B 26600:Tyrosine Kinase Activity KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20631589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncology+Reports&rft.atitle=Expression+levels+of+eIF4E%2C+VEGF%2C+and+cyclin+D1%2C+and+correlation+of+eIF4E+with+VEGF+and+cyclin+D1+in+multi-tumor+tissue+microarray&rft.au=Yang%2C+S+X%3BHewitt%2C+S+M%3BSteinberg%2C+S+M%3BLiewehr%2C+D+J%3BSwain%2C+S+M&rft.aulast=Yang&rft.aufirst=S&rft.date=2007-02-01&rft.volume=17&rft.issue=2&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Oncology+Reports&rft.issn=1021335X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Translation; glioblastoma multiforme; Translation initiation; Angiogenesis; Tumors; Initiation factor eIF-4E; Melanoma; Colon; Lung; Ovaries; Immunohistochemistry; cap-binding protein; Prostate; Lymphoma; cyclin D1 ER - TY - JOUR T1 - Protection of antiterminator RNA by the transcript elongation complex AN - 20454907; 9149992 AB - SummaryNascent transcripts encoded by the putL and putR sites of phage HK022 bind the transcript elongation complex and suppress termination at downstream transcription terminators. We report here that the chemical stability of putL RNA is considerably greater than that of the typical Escherichia coli message because the elongation complex protects this RNA from degradation. When binding to the elongation complex was prevented by mutation of either putL or RNA polymerase, RNA stability decreased more than 50-fold. The functional modification conferred by putL RNA on the elongation complex is also long-lived: the efficiency of terminator suppression remained high for at least 10kb from the putL site. We find that RNase III rapidly and efficiently cleaved the transcript just downstream of the putL sequences, but such cleavage changed neither the stability of putL RNA nor the efficiency of antitermination. These results argue that the continuity of the RNA that connects put sequences to the growing point is not required for persistence of the antiterminating modification in vivo. JF - Molecular Microbiology AU - Sloan, Sieghild AU - Rutkai, Edit AU - King, Rodney A AU - Velikodvorskaya, Tatyana AU - Weisberg, Robert A AD - Section on Microbial Genetics, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, MD20892-2785, USA. Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1197 EP - 1208 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 63 IS - 4 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Elongation KW - DNA-directed RNA polymerase KW - Escherichia coli KW - Phage HK022 KW - Transcription KW - Ribonuclease III KW - Mutation KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20454907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Protection+of+antiterminator+RNA+by+the+transcript+elongation+complex&rft.au=Sloan%2C+Sieghild%3BRutkai%2C+Edit%3BKing%2C+Rodney+A%3BVelikodvorskaya%2C+Tatyana%3BWeisberg%2C+Robert+A&rft.aulast=Sloan&rft.aufirst=Sieghild&rft.date=2007-02-01&rft.volume=63&rft.issue=4&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05579.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Phages; Elongation; DNA-directed RNA polymerase; Ribonuclease III; Transcription; Mutation; Escherichia coli; Phage HK022 DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05579.x ER - TY - JOUR T1 - Shotgun electroelution: A proteomic tool for simultaneous sample elution from whole SDS-polyacrylamide gel slabs AN - 20403603; 7762570 AB - A high-throughput device has been constructed which allows parallel electroelution of separated SDS-protein bands directly from intact unsectioned polyacrylamide gel slabs as well as single electroelution of certain protein spots into a 384-well standard flat-bottom multiwell plate. The prototype provides complete, quick elution for proteomics from 1-D or from 2-D gels without gel sectioning. Since the elution chamber matrix requires no assembly, sample handling can be easily carried out by existing robotic workstations. The current design is a good candidate for automation of spot elution since there are no moving liquid containing components in the apparatus. Eight SDS-proteins were eluted in test runs and an average 70% sample recovery was achieved by re-electrophoresis of the electroeluates. JF - Electrophoresis AU - Antal, Jozsef AU - Banyasz, Borbala AU - Buzas, Zsuzsanna AD - Section on Metabolic Analysis and Mass Spectrometry, Laboratory of Cellular and Molecular Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, zbuzas@yahoo.com Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 508 EP - 511 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 28 IS - 4 SN - 0173-0835, 0173-0835 KW - Biotechnology and Bioengineering Abstracts KW - Gels KW - Sectioning KW - Automation KW - robotics KW - proteomics KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20403603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Electrophoresis&rft.atitle=Shotgun+electroelution%3A+A+proteomic+tool+for+simultaneous+sample+elution+from+whole+SDS-polyacrylamide+gel+slabs&rft.au=Antal%2C+Jozsef%3BBanyasz%2C+Borbala%3BBuzas%2C+Zsuzsanna&rft.aulast=Antal&rft.aufirst=Jozsef&rft.date=2007-02-01&rft.volume=28&rft.issue=4&rft.spage=508&rft.isbn=&rft.btitle=&rft.title=Electrophoresis&rft.issn=01730835&rft_id=info:doi/10.1002%2Felps.200600634 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; robotics; Gels; Automation; Sectioning DO - http://dx.doi.org/10.1002/elps.200600634 ER - TY - JOUR T1 - Increased immunofluorescence sensitivity using 532 nm laser excitation AN - 20397223; 7760069 AB - Objective: We evaluated the use of a high power, diode pulsed solid-state laser emitting 532 nm light for immunofluorescence applications. We compared the sensitivity and utility of this laser with the standard 488 nm excitation. Methods: A flow cytometer was equipped with both a 488 nm and a 532 nm laser; fluorescence emissions from each laser were collected using the same filters and the same detector system. Cells or compensation beads (e.g. latex beads coated with anti- antibodies) were stained with monoclonal antibodies conjugated to phycoerythrin (PE) as well as the PE tandem dyes TRPE, Cy5PE, Cy5.5PE, and Cy7PE. The sensitivity of detection of these reagents as well as those in heavily compensated channels was quantified by measuring the spreading error for a primary detector into a secondary detector. Results: Measurement of the fluorescence emission of PE and PE-tandem dyes was considerably more sensitive when using 532 nm excitation (150 mW) as compared with 488 nm excitation (20 mW). In addition, as the absolute number of photoelectrons collected was greater, there was less measurement-error-induced spread into the compensated channels. As an example, when comparing the spreading error of PE labeled cells into the TRPE detector, the green laser was found to be 15-fold more sensitive as compared with the blue laser. In addition, the blue laser produced more autofluoresent signal from cells as compared with the green laser. Together, these advantages of the 532 nm excitation line provides for a significantly improved detection of immunofluorescence staining. JF - Cytometry Part A AU - Perfetto, Stephen P AU - Roederer, Mario AD - Vaccine Research Center, NIAID, NIH, Bethesda, MD, sperfetto@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 73 EP - 79 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 71A IS - 2 SN - 1552-4922, 1552-4922 KW - Biotechnology and Bioengineering Abstracts KW - Filters KW - phycoerythrins KW - Fluorescence KW - Spreading KW - Dyes KW - Monoclonal antibodies KW - Latex beads KW - Lasers KW - Immunofluorescence KW - Cytometry KW - Light effects KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20397223?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cytometry+Part+A&rft.atitle=Increased+immunofluorescence+sensitivity+using+532+nm+laser+excitation&rft.au=Perfetto%2C+Stephen+P%3BRoederer%2C+Mario&rft.aulast=Perfetto&rft.aufirst=Stephen&rft.date=2007-02-01&rft.volume=71A&rft.issue=2&rft.spage=73&rft.isbn=&rft.btitle=&rft.title=Cytometry+Part+A&rft.issn=15524922&rft_id=info:doi/10.1002%2Fcyto.a.20358 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Lasers; Immunofluorescence; Spreading; Dyes; Fluorescence; Latex beads; Monoclonal antibodies; phycoerythrins; Light effects; Cytometry; Filters DO - http://dx.doi.org/10.1002/cyto.a.20358 ER - TY - JOUR T1 - Emissions of polycyclic aromatic hydrocarbons (PAHs) from the pyrolysis of scrap tires AN - 20360416; 7573354 AB - This work investigated the PAHs generated in a waste-tire pyrolysis process and the PAHs removal by a wet scrubber (WSB) and a flare. IND, DBA, and BaP were found to dominate in the powders of scrap tires before the pyrolysis. The PAHs in the carbon blacks formed in the pyrolysis were mainly 2-, 3-, 6-, and 7-ring PAHs. Nap was the most predominant water-phase PAH in the WSB effluent. About 40% of the water-phase total-PAHs in the WSB effluent were contributed by nine carcinogenic PAHs. NaP, IND, and COR displayed higher mean gas- and particulate-phase concentrations than the other PAHs in the flare exhaust. The mean removal efficiencies of individual PAHs, total-PAHs, and high carcinogenic BaP+IND+DBA were 39.1-90.4%, 76.2%, and 84.9%, respectively for the WSB. For the flare, the mean removal efficiencies of gaseous, particulate, and combined (gaseous+particulate) total-PAHs were 59.8%, 91.2%, and 66.8%, respectively, whereas the removal efficiencies were 91.0%, 80.1%, and 89.1%, respectively for the total-BaPeq. However, the gaseous BaA displayed a negative mean removal efficiency. The total PAH emission rate and factor estimated for the scrap tire pyrolysis plant were 42.3gd-1 and 4.00mgkg-tire-1, respectively. JF - Atmospheric Environment AU - Chen, Shui-Jen AU - Su, Hung-Bin AU - Chang, Juu-En AU - Lee, Wen-Jhy AU - Huang, Kuo-Lin AU - Hsieh, Lien-Te AU - Huang, Yi-Chu AU - Lin, Wen-Yinn AU - Lin, Chih-Chung AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu, PingTung 91201, Taiwan, ROC, huangkL@mail.npust.edu.tw Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1209 EP - 1220 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 41 IS - 6 SN - 1352-2310, 1352-2310 KW - Pollution Abstracts; Meteorological & Geoastrophysical Abstracts KW - PAHs KW - Pyrolysis KW - Tires KW - Air pollution control devices (APCDs) KW - Air pollution control KW - Particulates KW - Effluents KW - Polycyclic aromatic hydrocarbon emissions KW - black carbon KW - Carcinogenicity KW - Particulate matter emissions KW - Scrubbers KW - Emissions KW - polycyclic aromatic hydrocarbons KW - Pollution control equipment KW - Polycyclic aromatic hydrocarbons in atmosphere KW - M2 551.510.42:Air Pollution (551.510.42) KW - P 0000:AIR POLLUTION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20360416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Atmospheric+Environment&rft.atitle=Emissions+of+polycyclic+aromatic+hydrocarbons+%28PAHs%29+from+the+pyrolysis+of+scrap+tires&rft.au=Chen%2C+Shui-Jen%3BSu%2C+Hung-Bin%3BChang%2C+Juu-En%3BLee%2C+Wen-Jhy%3BHuang%2C+Kuo-Lin%3BHsieh%2C+Lien-Te%3BHuang%2C+Yi-Chu%3BLin%2C+Wen-Yinn%3BLin%2C+Chih-Chung&rft.aulast=Chen&rft.aufirst=Shui-Jen&rft.date=2007-02-01&rft.volume=41&rft.issue=6&rft.spage=1209&rft.isbn=&rft.btitle=&rft.title=Atmospheric+Environment&rft.issn=13522310&rft_id=info:doi/10.1016%2Fj.atmosenv.2006.09.041 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Particulate matter emissions; Polycyclic aromatic hydrocarbons in atmosphere; Polycyclic aromatic hydrocarbon emissions; Pyrolysis; black carbon; Carcinogenicity; Scrubbers; Tires; Emissions; polycyclic aromatic hydrocarbons; Air pollution control; Particulates; Pollution control equipment; Effluents DO - http://dx.doi.org/10.1016/j.atmosenv.2006.09.041 ER - TY - JOUR T1 - Prepubertal Gynecomastia Linked to Lavender and Tea Tree Oils AN - 20327922; 7519913 AB - Most cases of male prepubertal gynecomastia are classified as idiopathic. We investigated possible causes of gynecomastia in three prepubertal boys who were otherwise healthy and had normal serum concentrations of endogenous steroids. In all three boys, gynecomastia coincided with the topical application of products that contained lavender and tea tree oils. Gynecomastia resolved in each patient shortly after the use of products containing these oils was discontinued. Furthermore, studies in human cell lines indicated that the two oils had estrogenic and antiandrogenic activities. We conclude that repeated topical exposure to lavender and tea tree oils probably caused prepubertal gynecomastia in these boys. JF - New England Journal of Medicine AU - Henley, D V AU - Lipson, N AU - Korach, K S AU - Bloch, CA AD - Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, MD B3-02, P.O. Box 12233, Research Triangle Park, NC 27709, USA, korach@niehs.nih.gov Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 479 EP - 485 VL - 356 IS - 5 SN - 0028-4793, 0028-4793 KW - Toxicology Abstracts KW - antiandrogenic activity KW - Tea KW - Oils KW - Lavandula KW - Steroid hormones KW - Gynecomastia KW - Topical application KW - X 24340:Cosmetics, Toiletries & Household Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20327922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=New+England+Journal+of+Medicine&rft.atitle=Prepubertal+Gynecomastia+Linked+to+Lavender+and+Tea+Tree+Oils&rft.au=Henley%2C+D+V%3BLipson%2C+N%3BKorach%2C+K+S%3BBloch%2C+CA&rft.aulast=Henley&rft.aufirst=D&rft.date=2007-02-01&rft.volume=356&rft.issue=5&rft.spage=479&rft.isbn=&rft.btitle=&rft.title=New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - antiandrogenic activity; Tea; Oils; Steroid hormones; Gynecomastia; Topical application; Lavandula ER - TY - JOUR T1 - Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals AN - 20282778; 7640449 AB - Modified vaccinia Ankara (MVA) was evaluated as an alternative to Dryvax® in vaccinia-naive and vaccinia-immune adult volunteers. Subjects received intramuscular MVA or placebo followed by Dryvax® challenge at 3 months. Two or more doses of MVA prior to Dryvax® reduced severity of lesion formation, decreased magnitude and duration of viral shedding, and augmented post-Dryvax® vaccinia-specific CD8+ T cell responses and extracellular enveloped virus protein-specific antibody responses. MVA vaccination is safe and immunogenic and improves the safety and immunogenicity of subsequent Dryvax® vaccination supporting the potential for using MVA as a vaccine in the general population to improve immunity to orthopoxviruses. JF - Vaccine AU - Parrino, Janie AU - McCurdy, Lewis H AU - Larkin, Brenda D AU - Gordon, Ingelise J AU - Rucker, Steven E AU - Enama, Mary E AU - Koup, Richard A AU - Roederer, Mario AU - Bailer, Robert T AU - Moodie, Zoe AU - Gu, Lin AU - Yan, Lihan AU - Graham, Barney S AD - Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States, bgraham@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1513 EP - 1525 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 8 SN - 0264-410X, 0264-410X KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Smallpox KW - Orthopoxvirus KW - Vaccine KW - vaccines KW - Antibodies KW - Immunogenicity KW - Vaccinia KW - Lymphocytes T KW - Lesions KW - Vaccines KW - CD8 antigen KW - Turkey, Ankara KW - Vaccination KW - Side effects KW - V 22350:Immunology KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20282778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Safety%2C+immunogenicity+and+efficacy+of+modified+vaccinia+Ankara+%28MVA%29+against+Dryvax+challenge+in+vaccinia-naive+and+vaccinia-immune+individuals&rft.au=Parrino%2C+Janie%3BMcCurdy%2C+Lewis+H%3BLarkin%2C+Brenda+D%3BGordon%2C+Ingelise+J%3BRucker%2C+Steven+E%3BEnama%2C+Mary+E%3BKoup%2C+Richard+A%3BRoederer%2C+Mario%3BBailer%2C+Robert+T%3BMoodie%2C+Zoe%3BGu%2C+Lin%3BYan%2C+Lihan%3BGraham%2C+Barney+S&rft.aulast=Parrino&rft.aufirst=Janie&rft.date=2007-02-01&rft.volume=25&rft.issue=8&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.10.047 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antibodies; Vaccinia; Immunogenicity; Lymphocytes T; CD8 antigen; Vaccines; Vaccination; vaccines; Lesions; Side effects; Turkey, Ankara DO - http://dx.doi.org/10.1016/j.vaccine.2006.10.047 ER - TY - JOUR T1 - Cryopreservation of porcine articular cartilage: MRI and biochemical results after different freezing protocols AN - 20267697; 7416278 AB - The objective of this study was to investigate the effects of cryopreservation on the components of articular cartilage (AC) matrix by utilizing magnetic resonance imaging (MRI) and biochemical assessments. Porcine AC (10mm osteochondral dowels) was collected into four groups - (1) phosphate buffered saline (PBS) control, (2) PBS snap frozen in liquid nitrogen, (3) slow-cooled in dimethyl sulfoxide (DMSO), and (4) slow cooled in PBS (in absence of DMSO). MRI results demonstrated three distinct zones in the cartilage. After exposure to ice formation during cryopreservation procedures, alterations in MRI determined matrix fixed charged density and magnetization transfer rate were noted. In addition, biochemical assays demonstrated significant alterations in chondroitin sulfate and hydroxyproline content over time without differences in hydration or DNA content. In conclusion, MRI was able to detect some changes in the intact cartilage matrix structure consistent with biochemical assessments after ice formation during cryopreservation of intact porcine AC. Furthermore, biochemical assessments supported some of these findings and changed significantly after incubating the cartilage matrix for 36-72h in PBS in terms of chondroitin sulfate and hydroxyproline content. JF - Cryobiology AU - Laouar, L AU - Fishbein, K AU - McGann, LE AU - Horton, W E AU - Spencer, R G AU - Jomha, N M AD - NIH/National Institute on Aging, Intramural Research Program, GRC 4D-08, 5600 Nathan Shock Drive Baltimore, MD 21224, USA, spencerri@grc.nia.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 36 EP - 43 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 54 IS - 1 SN - 0011-2240, 0011-2240 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - Hydration KW - Ice KW - Hydroxyproline KW - Chondroitin sulfate KW - Magnetic resonance imaging KW - Freezing KW - Cryopreservation KW - Phosphate KW - DNA KW - Dimethyl sulfoxide KW - Cartilage (articular) KW - Nitrogen KW - Adenylate cyclase KW - W 30910:Imaging KW - T 2030:Cartilage and Cartilage Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20267697?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cryobiology&rft.atitle=Cryopreservation+of+porcine+articular+cartilage%3A+MRI+and+biochemical+results+after+different+freezing+protocols&rft.au=Laouar%2C+L%3BFishbein%2C+K%3BMcGann%2C+LE%3BHorton%2C+W+E%3BSpencer%2C+R+G%3BJomha%2C+N+M&rft.aulast=Laouar&rft.aufirst=L&rft.date=2007-02-01&rft.volume=54&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Cryobiology&rft.issn=00112240&rft_id=info:doi/10.1016%2Fj.cryobiol.2006.10.193 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Hydration; Ice; Hydroxyproline; Chondroitin sulfate; Magnetic resonance imaging; Freezing; Cryopreservation; Phosphate; Dimethyl sulfoxide; DNA; Cartilage (articular); Adenylate cyclase; Nitrogen DO - http://dx.doi.org/10.1016/j.cryobiol.2006.10.193 ER - TY - JOUR T1 - The histone deacetylase inhibitor FK228 given prior to adenovirus infection can boost infection in melanoma xenograft model systems AN - 20227554; 7289995 AB - A major limitation of adenovirus type 5-mediated cancer gene therapy is the inefficient infection of many cancer cells. Previously, we showed that treatment with low doses of the histone deacetylase inhibitor FK228 (FR901228, depsipeptide) increased coxsackie adenovirus receptor (CAR) levels, histone H3 acetylation, and adenovirus infection efficiencies as measured by viral transgene expression in cancer cell lines but not in cultured normal cells. To evaluate FK228 in vivo, the effects of FK228 therapy in athymic mice bearing LOX IMVI or UACC-62 human melanoma xenografts were examined. Groups of mice were treated with FK228 using several dosing schedules and the differences between treated and control animals were determined. In mice with LOX IMVI xenografts (n = 6), maximum CAR induction was observed 24 h following a single FK228 dose of 3.6 mg/kg with a 13.6 plus or minus 4.3-fold (mean plus or minus SD) increase in human CAR mRNA as determined by semiquantitative reverse transcription-PCR analysis. By comparison, mouse CAR levels in liver, kidney, and lung from the same animals showed little to no change. Maximum CAR protein induction of 9.2 plus or minus 4.8-fold was achieved with these treatment conditions and was associated with increased histone H3 acetylation. Adenovirus carrying a green fluorescent protein (GFP) transgene (2 x 10 super(9) viral particles) was injected into the xenografts and GFP mRNA levels were determined. A 7.4 plus or minus 5.2-fold increase in GFP mRNA was found 24 h following adenovirus injection into optimally FK228-treated mice (n = 10). A 4-fold increase in GFP protein-positive cells was found following FK228 treatment. These studies suggest that FK228 treatment prior to adenovirus infection could increase the efficiency of adenovirus gene therapy in xenograft model systems. [Mol Cancer Ther 2007; 6(2):496-505] JF - Molecular Cancer Therapeutics AU - Goldsmith, Merrill E AU - Aguila, Alian AU - Steadman, Kenneth AU - Martinez, Alfredo AU - Steinberg, Seth M AU - Alley, Michael C AU - Waud, William R AU - Bates, Susan E AU - Fojo, Tito AD - Medical Oncology Branch, Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 496 EP - 505 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 6 IS - 2 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Histone deacetylase KW - CAR protein KW - Gene therapy KW - Adenovirus KW - Animal models KW - Green fluorescent protein KW - Infection KW - Cancer KW - Melanoma KW - Acetylation KW - Tumor cell lines KW - Lung KW - Liver KW - Kidney KW - Xenografts KW - Histone H3 KW - N 14820:DNA Metabolism & Structure KW - W 30915:Pharmaceuticals & Vaccines KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=The+histone+deacetylase+inhibitor+FK228+given+prior+to+adenovirus+infection+can+boost+infection+in+melanoma+xenograft+model+systems&rft.au=Goldsmith%2C+Merrill+E%3BAguila%2C+Alian%3BSteadman%2C+Kenneth%3BMartinez%2C+Alfredo%3BSteinberg%2C+Seth+M%3BAlley%2C+Michael+C%3BWaud%2C+William+R%3BBates%2C+Susan+E%3BFojo%2C+Tito&rft.aulast=Goldsmith&rft.aufirst=Merrill&rft.date=2007-02-01&rft.volume=6&rft.issue=2&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; CAR protein; Gene therapy; Green fluorescent protein; Animal models; Infection; Cancer; Melanoma; Acetylation; Tumor cell lines; Lung; Kidney; Liver; Xenografts; Histone H3; Adenovirus ER - TY - JOUR T1 - Evaluating microarrays using a semiparametric approach: Application to the central carbon metabolism of Escherichia coli BL21 and JM109 AN - 20079796; 7272640 AB - Escherichia coli K (JM109) and E. coli B (BL21) are strains used routinely for recombinant protein production. These two strains grow and respond differently to environmental factors such as glucose and oxygen concentration. The differences have been attributed to differential expression of individual genes that constitute certain metabolic pathways that are part of the central carbon metabolism. By implementing a semiparametric algorithm, which is based on a density ratio model, it was possible to compare and quantify the expression patterns of groups of genes involved in several central carbon metabolic pathways. The groups comprising the glyoxylate shunt, TCA cycle, fatty acid, and gluconeogenesis and anaplerotic pathways were expressed differently between the two strains, whereas no differences were apparent for the groups comprising either glycolysis or the pentose phosphate pathway. These results further characterized differences between the two E. coli strains and illustrated the potency of the semiparametric algorithm. JF - Genomics AU - Phue, J N AU - Kedem, B AU - Jaluria, P AU - Shiloach, J AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 14A, Room 170, 9000 Rockville Pike, Bethesda, MD 20892, USA, yossi@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 300 EP - 305 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 89 IS - 2 SN - 0888-7543, 0888-7543 KW - Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Pentose phosphate pathway KW - Glucose KW - Algorithms KW - Environmental factors KW - Oxygen KW - Carbon KW - Shunts KW - Gluconeogenesis KW - Escherichia coli KW - Fatty acids KW - Metabolic pathways KW - Anaplerotic pathways KW - Tricarboxylic acid cycle KW - Glycolysis KW - Metabolism KW - W 30960:Bioinformatics & Computer Applications KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20079796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomics&rft.atitle=Evaluating+microarrays+using+a+semiparametric+approach%3A+Application+to+the+central+carbon+metabolism+of+Escherichia+coli+BL21+and+JM109&rft.au=Phue%2C+J+N%3BKedem%2C+B%3BJaluria%2C+P%3BShiloach%2C+J&rft.aulast=Phue&rft.aufirst=J&rft.date=2007-02-01&rft.volume=89&rft.issue=2&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Genomics&rft.issn=08887543&rft_id=info:doi/10.1016%2Fj.ygeno.2006.10.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Pentose phosphate pathway; Algorithms; Glucose; Environmental factors; Oxygen; Carbon; Shunts; Gluconeogenesis; Metabolic pathways; Fatty acids; Anaplerotic pathways; Tricarboxylic acid cycle; Glycolysis; Metabolism; Escherichia coli DO - http://dx.doi.org/10.1016/j.ygeno.2006.10.004 ER - TY - JOUR T1 - MR lymphangiography using dendrimer-based contrast agents: A comparison at 1.5T and 3.0T AN - 20030270; 8368401 AB - Most macromolecular contrast agents (CAs) show lower r1 and higher r2 relaxivities at 3.0T than at 1.5T. MR lymphangiography in mice using a macromolecular G6 dendrimer-based CA was serially performed and compared at both 1.5T and 3.0T. The r1 and r2 relaxivities of the G6 CA were 25 and 78/s/mM at 1.5T and 17 and 82/s/mM at 3.0T, respectively. The lymph node (LN)-to-fat ratios (LN signal intensity (SI)/fat SI) of T1-weighted 3D-fast spoiled gradient-echo (3D-FSPGR) were 3.2 - 0.4 (mean - standard deviation (SD)) at 1.5T and 2.7 - 0.3 at 3.0T (P = 0.021), and the LN-to-fat ratios of T2/T1-weighted 3D-fast imaging employing steady-state acquisition with phase cycling (3D-FIESTA-C) were 1.8 - 0.2 at 1.5T and 1.2 - 0.4 at 3.0T (P = 0.003). Although 3D-FSPGR successfully delineated the LNs at both 1.5T and 3.0T, 3D-FIESTA-C at 3.0T failed to visualize the LNs. Magn Reson Med 57:431-436, 2007. JF - Magnetic Resonance in Medicine AU - Hama, Yukihiro AU - Bernardo, Marcelino AU - Regino, Celeste A S AU - Koyama, Yoshinori AU - Brechbiel, Martin W AU - Krishna, Murali C AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA, Kobayash@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 431 EP - 436 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 2 SN - 0740-3194, 0740-3194 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Macromolecules KW - imaging KW - Lymph nodes KW - Lymphangiography KW - Standard deviation KW - Contrast media KW - N.M.R. KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20030270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=MR+lymphangiography+using+dendrimer-based+contrast+agents%3A+A+comparison+at+1.5T+and+3.0T&rft.au=Hama%2C+Yukihiro%3BBernardo%2C+Marcelino%3BRegino%2C+Celeste+A+S%3BKoyama%2C+Yoshinori%3BBrechbiel%2C+Martin+W%3BKrishna%2C+Murali+C%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2007-02-01&rft.volume=57&rft.issue=2&rft.spage=431&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21126 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Contrast media; Macromolecules; Lymphangiography; N.M.R.; Lymph nodes; imaging; Standard deviation DO - http://dx.doi.org/10.1002/mrm.21126 ER - TY - JOUR T1 - Age-dependent accumulation of mtDNA mutations in murine hematopoietic stem cells is modulated by the nuclear genetic background AN - 19995218; 7287658 AB - Alterations in mitochondrial DNA (mtDNA) and consequent loss of mitochondrial function underlie the mitochondrial theory of aging. In this study, we systematically analyzed the mtDNA control region somatic mutation pattern in 2864 single hematopoietic stem cells (HSCs) and progenitors, isolated by flow cytometry sorting on Lin super(-)Kit super(+)CD34 super(-) parameters from young and old C57BL/6 (B6) and BALB/cBy (BALB) mice, to test the hypothesis that the accumulated mtDNA mutations in HSCs were strain-correlated and associated with HSC functional senescence during aging. An increased level of mtDNA mutations in single HSCs was observed in old B6 when compared with young B6 mice (P=0.003); in contrast, no significant age-dependent accumulation of mutations was observed in BALB mice (old versus young, P=0.202) and the level of mutations in both young and old BALB mice was close to that of old B6 mice (P>0.280). Cellular reactive oxygen species (ROS) in mouse HSCs could not be correlated with the level of mtDNA mutations in these cells, although B6 mice had a higher proportion of ROS super(-) cells when compared with the BALB mice. Propagation assays of single HSCs showed B6 cells form larger colonies compared with cells from BALB mice, irrespective of age and mtDNA mutation load. We infer from our data that age-related mtDNA somatic mutation accumulation in mouse HSCs is influenced by the nuclear genetic background and that these mutations may not obviously correlate to either cellular ROS content or HSC senescence. JF - Human Molecular Genetics AU - Yao, Yong-Gang AU - Ellison, Felicia M AU - McCoy, JPhilip AU - Chen, Jichun AU - Young, Neal S AD - Hematology Branch and. Flow Cytometry Core Facility, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1202, USA Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 286 EP - 294 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 16 IS - 3 SN - 0964-6906, 0964-6906 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Age KW - Data processing KW - Aging KW - Mitochondria KW - Flow cytometry KW - Mitochondrial DNA KW - Stem cells KW - Colonies KW - Reactive oxygen species KW - Hemopoiesis KW - Senescence KW - Mutation KW - G 07870:Mammals KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19995218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Molecular+Genetics&rft.atitle=Age-dependent+accumulation+of+mtDNA+mutations+in+murine+hematopoietic+stem+cells+is+modulated+by+the+nuclear+genetic+background&rft.au=Yao%2C+Yong-Gang%3BEllison%2C+Felicia+M%3BMcCoy%2C+JPhilip%3BChen%2C+Jichun%3BYoung%2C+Neal+S&rft.aulast=Yao&rft.aufirst=Yong-Gang&rft.date=2007-02-01&rft.volume=16&rft.issue=3&rft.spage=286&rft.isbn=&rft.btitle=&rft.title=Human+Molecular+Genetics&rft.issn=09646906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Age; Colonies; Stem cells; Mitochondrial DNA; Data processing; Reactive oxygen species; Aging; Hemopoiesis; Mitochondria; Senescence; Mutation ER - TY - JOUR T1 - Self-Renewing and Differentiating Properties of Cortical Neural Stem Cells Are Selectively Regulated by Basic Fibroblast Growth Factor (FGF) Signaling via Specific FGF Receptors AN - 19990484; 7289418 AB - Developmental processes mediating the initiation of lineage commitment from self-renewing neural stem cells (NSCs) remain mostly unclear because of the persisting ambiguity in identifying true NSCs from proliferative lineage-restricted progenitors (LRPs), which are directly or indirectly derived from NSCs. Our multilineage immunohistochemical analyses of early embryonic rat telencephalon at the onset of neurogenesis revealed clear dorsoventral gradients in the emergence of two types of neuronal progenitors (NPs) from multilineage-negative NSCs. Enumeration of NSCs using comprehensive flow cytometric analysis demonstrated that their precipitous decline in vivo involved both active differentiation into NPs and an increased propensity toward apoptosis. Both processes paralleled the dorsoventral changes in fibroblast growth factor receptor (FGFR) expressions. NSCs residing in the dorsal telencephalon coexpressed FGFR1 and FGFR3, whereas those residing in the ventral telencephalon also expressed FGFR2. NSCs exposed to basic fibroblast growth factor (bFGF) in vitro generated four stereotypical clonal expansion states: efficiently self-renewing, inefficiently self-renewing limited by apoptosis, exclusively neurogenic, and multipotential, generating up to five types of LRPs. The plasticity among these expansion states depended on ambient [bFGF], telencephalic developmental stage, and differential activation/inactivation of specific FGFRs. Coactivation of FGFR1 and FGFR3 promoted symmetrical divisions of NSCs (self-renewal), whereas inactivation of either triggered asymmetrical divisions and neurogenesis from these cells. Developmental upregulation of FGFR2 expression correlated with a shift of NSCs into a multipotential state or apoptosis. These results provide new insights regarding the roles of FGFRs in diversification of NSC properties and initiation of neural lineage-restricted differentiation. JF - Journal of Neuroscience AU - Maric, Dragan AU - Fiorio Pla, Alessandra AU - Chang, Yoong Hee AU - Barker, Jeffery L AD - Laboratory of Neurophysiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, Laboratory of Physiology, Department of Human and Animal Biology, University of Torino, 10123 Torino, Italy, and Nanostructured Interfaces and Surfaces Centre of Excellence, 10125 Torino, Italy Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1836 EP - 1852 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 27 IS - 8 SN - 0270-6474, 0270-6474 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Fibroblast growth factor receptors KW - Plasticity (developmental) KW - Apoptosis KW - Receptor mechanisms KW - Fibroblast growth factor receptor 2 KW - Fibroblast growth factor receptor 1 KW - Developmental stages KW - Flow cytometry KW - Differentiation KW - Neurogenesis KW - Nervous system KW - Cortex KW - Fibroblast growth factor KW - Embryos KW - Telencephalon KW - Fibroblast growth factor 2 KW - Neural stem cells KW - Signal transduction KW - N3 11003:Developmental neuroscience KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19990484?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Self-Renewing+and+Differentiating+Properties+of+Cortical+Neural+Stem+Cells+Are+Selectively+Regulated+by+Basic+Fibroblast+Growth+Factor+%28FGF%29+Signaling+via+Specific+FGF+Receptors&rft.au=Maric%2C+Dragan%3BFiorio+Pla%2C+Alessandra%3BChang%2C+Yoong+Hee%3BBarker%2C+Jeffery+L&rft.aulast=Maric&rft.aufirst=Dragan&rft.date=2007-02-01&rft.volume=27&rft.issue=8&rft.spage=1836&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fibroblast growth factor receptors; Plasticity (developmental); Apoptosis; Fibroblast growth factor receptor 2; Receptor mechanisms; Fibroblast growth factor receptor 1; Developmental stages; Flow cytometry; Differentiation; Nervous system; Neurogenesis; Cortex; Fibroblast growth factor; Telencephalon; Embryos; Fibroblast growth factor 2; Neural stem cells; Signal transduction ER - TY - JOUR T1 - Pharmacokinetics and Safety of Indinavir in Human Immunodeficiency Virus-Infected Pregnant Women AN - 19986147; 7248876 AB - Human immunodeficiency virus-infected women (n = 16) received indinavir (800 mg three times a day) plus zidovudine plus lamivudine from 14 to 28 weeks of gestation to 12 weeks postpartum. Two women and eight infants experienced grade 3 or 4 toxicities that were possibly treatment related. Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy. JF - Antimicrobial Agents & Chemotherapy AU - Unadkat, Jashvant D AU - Wara, Diane W AU - Hughes, Michael D AU - Mathias, Anita A AU - Holland, Diane T AU - Paul, Mary E AU - Connor, James AU - Huang, Sharon AU - Nguyen, Bach-Yen AU - Watts, DHeather AU - Mofenson, Lynne M AU - Smith, Elizabeth AU - Deutsch, Paul AU - Kaiser, Kathleen A AU - Tuomala, Ruth E AD - Department of Pharmaceutics, University of Washington, Seattle, Washington. Department of Pediatrics, University of California San Francisco, San Francisco, California. Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, Massachusetts. Division of Clinical Pharmacology and Developmental Therapeutics, University of California, San Diego, California. Baylor College of Medicine, Houston, Texas. Merck Research Laboratories, West Point, Pennsylvania. Pediatric Adolescent and Maternal AIDS Branch, National Institute of Child Health and Human Development, Bethesda, Maryland. Pediatric Medical Branch, Therapeutics Research Plan, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland. Frontier Science and Technology Research Foundation. Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, Massachusetts Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 783 EP - 786 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 2 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Indinavir KW - Immunodeficiency KW - Zidovudine KW - Lamivudine KW - Toxicity KW - Pharmacokinetics KW - Antimicrobial agents KW - Pregnancy KW - Postpartum KW - Gestation KW - Intestine KW - Liver KW - Infants KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19986147?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Pharmacokinetics+and+Safety+of+Indinavir+in+Human+Immunodeficiency+Virus-Infected+Pregnant+Women&rft.au=Unadkat%2C+Jashvant+D%3BWara%2C+Diane+W%3BHughes%2C+Michael+D%3BMathias%2C+Anita+A%3BHolland%2C+Diane+T%3BPaul%2C+Mary+E%3BConnor%2C+James%3BHuang%2C+Sharon%3BNguyen%2C+Bach-Yen%3BWatts%2C+DHeather%3BMofenson%2C+Lynne+M%3BSmith%2C+Elizabeth%3BDeutsch%2C+Paul%3BKaiser%2C+Kathleen+A%3BTuomala%2C+Ruth+E&rft.aulast=Unadkat&rft.aufirst=Jashvant&rft.date=2007-02-01&rft.volume=51&rft.issue=2&rft.spage=783&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Indinavir; Immunodeficiency; Lamivudine; Zidovudine; Toxicity; Pharmacokinetics; Pregnancy; Antimicrobial agents; Postpartum; Gestation; Liver; Intestine; Infants ER - TY - JOUR T1 - Hematopoietic stem cells promote the expansion and function of adoptively transferred antitumor CD8 super(+) T cells AN - 19981452; 7485620 AB - Depleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD8 super(+) T cells significantly enhances tumor treatment. In the current study, superior antitumor efficacy was achieved by further increasing the intensity of lymphodepletion to a level that required HSC transplantation. Surprisingly, the HSC transplant and not the increased lymphodepletion caused a robust expansion of adoptively transferred tumor-specific CD8 super(+) T cells. The HSC-driven cell expansion of effector, but not of naive, CD8 super(+) T cells was independent of in vivo restimulation by MHC class I-expressing APCs. Simultaneously, HSCs also facilitated the reconstitution of the host lymphoid compartment, including inhibitory elements, not merely via the production of progeny cells but by enhancing the expansion of cells that had survived lymphodepletion. Profound lymphodepletion, by myeloablation or by genetic means, focused the nonspecific HSC boost preferentially toward the transferred tumor-specific T cells, leading to successful tumor treatment. These findings indicate that CD8 super(+) T cell-mediated tumor responses can be efficiently driven by HSCs in the myeloablative setting and have substantial implications for the design of new antitumor immunotherapies. JF - Journal of Clinical Investigation AU - Wrzesinski, Claudia AU - Paulos, Chrystal M AU - Gattinoni, Luca AU - Palmer, Douglas C AU - Kaiser, Andrew AU - Yu, Zhiya AU - Rosenberg, Steven A AU - Restifo, Nicholas P AD - National Cancer Institute, NIH, Bethesda, Maryland, USA., wrzesinc@mail.nih.gov(C.Wrzesinski). Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 492 EP - 501 PB - American Society for Clinical Investigation, 35 Research Drive, Suite 300 Ann Arbor MI 48103 USA, [mailto:asci@the-jci-org], [URL:http://www.asci-jci.org] VL - 117 IS - 2 SN - 0021-9738, 0021-9738 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Stem cells KW - adenomatous polyposis coli KW - Immunotherapy KW - Lymphocytes T KW - Adoptive transfer KW - Major histocompatibility complex KW - Progeny KW - CD8 antigen KW - Tumors KW - Antigen-presenting cells KW - Antitumor activity KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19981452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Investigation&rft.atitle=Hematopoietic+stem+cells+promote+the+expansion+and+function+of+adoptively+transferred+antitumor+CD8+super%28%2B%29+T+cells&rft.au=Wrzesinski%2C+Claudia%3BPaulos%2C+Chrystal+M%3BGattinoni%2C+Luca%3BPalmer%2C+Douglas+C%3BKaiser%2C+Andrew%3BYu%2C+Zhiya%3BRosenberg%2C+Steven+A%3BRestifo%2C+Nicholas+P&rft.aulast=Wrzesinski&rft.aufirst=Claudia&rft.date=2007-02-01&rft.volume=117&rft.issue=2&rft.spage=492&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Investigation&rft.issn=00219738&rft_id=info:doi/10.1172%2FJCI30414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Stem cells; adenomatous polyposis coli; Immunotherapy; Adoptive transfer; Lymphocytes T; Major histocompatibility complex; Progeny; Antigen-presenting cells; Tumors; CD8 antigen; Antitumor activity DO - http://dx.doi.org/10.1172/JCI30414 ER - TY - JOUR T1 - Combination Therapy with a Long-Acting [beta]-Agonist and a Leukotriene Antagonist in Moderate Asthma AN - 199604112; 16973987 AB - Long-acting beta-agonists (LABAs) and inhaled corticosteroids administered together appear to be complementary in terms of effects on asthma control. The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well. We sought to determine whether the combination of the LTRA montelukast and the LABA salmeterol could provide an effective therapeutic strategy for asthma. In a randomized, placebo-controlled, crossover study of 192 subjects with moderate asthma, we compared the clinical efficacy of regular treatment over 14 weeks with the combination of montelukast and salmeterol to that with the combination of beclomethasone and salmeterol in moderate asthma. The primary efficacy outcome was time to treatment failure. Three months after the randomization of the last subject, the Data and Safety Monitoring Board determined that the primary research question had been answered and terminated the trial. The combination of montelukast and salmeterol was inferior to the combination of beclomethasone and salmeterol as judged by protection against asthma treatment failures (p = 0.0008), lung function (26 L/min difference in a.m. peak expiratory flow rate, p = 0.011), asthma control score (0.22 difference in Asthma Control Questionnaire score, p = 0.038), and markers of inflammation and airway reactivity. Patients with moderate asthma similar to those we studied should not substitute the combination of an LTRA and an LABA for the combination of inhaled corticosteroid and an LABA. JF - American Journal of Respiratory and Critical Care Medicine AU - Deykin, Aaron AU - Wechsler, Michael E AU - Boushey, Homer A AU - Chinchilli, Vernon M AU - et al Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 228 EP - 34 CY - New York PB - American Thoracic Society VL - 175 IS - 3 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Acetates KW - Adrenal Cortex Hormones KW - Adrenergic beta-Agonists KW - Anti-Asthmatic Agents KW - Leukotriene Antagonists KW - Placebos KW - Quinolines KW - salmeterol KW - montelukast KW - Albuterol KW - Double-Blind Method KW - Combined Modality Therapy KW - Humans KW - Aged KW - Albuterol -- therapeutic use KW - Adrenal Cortex Hormones -- therapeutic use KW - Adrenal Cortex Hormones -- administration & dosage KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Administration, Inhalation KW - Adolescent KW - Female KW - Male KW - Asthma -- drug therapy KW - Albuterol -- analogs & derivatives KW - Quinolines -- therapeutic use KW - Acetates -- therapeutic use KW - Anti-Asthmatic Agents -- therapeutic use KW - Leukotriene Antagonists -- therapeutic use KW - Adrenergic beta-Agonists -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199604112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Combination+Therapy+with+a+Long-Acting+%5Bbeta%5D-Agonist+and+a+Leukotriene+Antagonist+in+Moderate+Asthma&rft.au=Deykin%2C+Aaron%3BWechsler%2C+Michael+E%3BBoushey%2C+Homer+A%3BChinchilli%2C+Vernon+M%3Bet+al&rft.aulast=Deykin&rft.aufirst=Aaron&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 1, 2007 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Higher Urine Nitric Oxide Is Associated with Improved Outcomes in Patients with Acute Lung Injury AN - 199603576; 17082495 AB - Nitrogen oxide (NO) species are markers for oxidative stress that may be pathogenic in acute lung injury (ALI). We tested two hypotheses in patients with ALI: (1) higher levels of urine NO would be associated with worse clinical outcomes, and (2) ventilation with lower VT would reduce urine NO as a result of less stretch injury. Urine NO levels were measured by chemiluminescence in 566 patients enrolled in the National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Network trial of 6 ml/kg versus 12 ml/kg VT ventilation. The data were expressed corrected and uncorrected for urine creatinine (Cr). Higher baseline levels of urine NO to Cr were associated with lower mortality (odds ratio, 0.43 per log(10) increase in the ratio), more ventilator-free days (mean increase, 1.9 d), and more organ-failure-free days (mean increase, 2.3 d) on multivariate analysis (p < 0.05 for all analyses). Similar results were obtained using urine NO alone. NO to Cr levels were higher on Day 3 in the 6 ml/kg than in the 12 ml/kg VT group (p = 0.04). Contrary to our hypothesis, higher urine NO was associated with improved outcomes in ALI at baseline and after treatment with the 6 ml/kg VT strategy. Higher endogenous NO may reflect less severe lung injury and better preservation of the pulmonary and systemic endothelium or may serve a protective function in patients with ALI. JF - American Journal of Respiratory and Critical Care Medicine AU - McClintock, Dana E AU - Ware, Lorraine B AU - Eisner, Mark D AU - Wickersham, Nancy AU - et al Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 256 EP - 62 CY - New York PB - American Thoracic Society VL - 175 IS - 3 SN - 1073449X KW - Medical Sciences--Respiratory Diseases KW - Biological Markers KW - Nitric Oxide KW - Creatinine KW - Severity of Illness Index KW - Creatinine -- urine KW - Disease Susceptibility KW - Humans KW - Prognosis KW - Aged KW - Outcome Assessment (Health Care) KW - Multivariate Analysis KW - Respiratory Distress Syndrome, Adult -- urine KW - Adult KW - Oxidative Stress KW - Middle Aged KW - Female KW - Male KW - Respiratory Distress Syndrome, Adult -- mortality KW - Nitric Oxide -- urine KW - Respiratory Distress Syndrome, Adult -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/199603576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.atitle=Higher+Urine+Nitric+Oxide+Is+Associated+with+Improved+Outcomes+in+Patients+with+Acute+Lung+Injury&rft.au=McClintock%2C+Dana+E%3BWare%2C+Lorraine+B%3BEisner%2C+Mark+D%3BWickersham%2C+Nancy%3Bet+al&rft.aulast=McClintock&rft.aufirst=Dana&rft.date=2007-02-01&rft.volume=175&rft.issue=3&rft.spage=256&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Respiratory+and+Critical+Care+Medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Thoracic Society Feb 1, 2007 N1 - Last updated - 2017-01-07 ER - TY - JOUR T1 - Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary Neurons AN - 19862688; 7288468 AB - An efficient research strategy integrating empirically guided, structure-based modeling and chemoinformatics was used to discover potent small molecule inhibitors of the botulinum neurotoxin serotype A light chain. First, a modeled binding mode for inhibitor 2-mercapto-3-phenylpropionyl-RATKML (K sub(i) = 330 nM) was generated, and required the use of a molecular dynamic conformer of the enzyme displaying the reorientation of surface loops bordering the substrate binding cleft. These flexible loops are conformationally variable in x-ray crystal structures, and the model predicted that they were pivotal for providing complementary binding surfaces and solvent shielding for the pseudo-peptide. The docked conformation of 2-mercapto-3-phenylpropionyl-RATKML was then used to refine our pharmacophore for botulinum serotype A light chain inhibition. Data base search queries derived from the pharmacophore were employed to mine small molecule (non-peptidic) inhibitors from the National Cancer Institute's Open Repository. Four of the inhibitors possess K sub(i) values ranging from 3.0 to 10.0 mu M. Of these, NSC 240898 is a promising lead for therapeutic development, as it readily enters neurons, exhibits no neuronal toxicity, and elicits dose-dependent protection of synaptosomal-associated protein (of 25 kDa) in a primary culture of embryonic chicken neurons. Isothermal titration calorimetry showed that the interaction between NSC 240898 and the botulinum A light chain is largely entropy-driven, and occurs with a 1:1 stoichiometry and a dissociation constant of 4.6 mu M. JF - Journal of Biological Chemistry AU - Burnett, James C AU - Ruthel, Gordon AU - Stegmann, Christian M AU - Panchal, Rekha G AU - Nguyen, Tam L AU - Hermone, Ann R AU - Stafford, Robert G AU - Lane, Douglas J AU - Kenny, Tara A AU - McGrath, Connor F AU - Wipf, Peter AU - Stahl, Andrea M AU - Schmidt, James J AU - Gussio, Rick AU - Brunger, Axel T AU - Bavari, Sina AD - Target Structure-based Drug Discovery Group, SAIC-Frederick, Inc., and the Information Technology Branch, Developmental Therapeutics Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, the United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, the Howard Hughes Medical Institute (HHMI) and Departments of Molecular and Cellular Physiology, Neurology and Neurological Sciences, and the Stanford Synchrotron Radiation Laboratory, Stanford University, School of Medicine, Stanford, California 94305, and the Combinatorial Chemistry Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 5004 EP - 5014 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - Light chains KW - Serotypes KW - Solvents KW - Enzymes KW - Botulinum toxin type A KW - Mines KW - Cancer KW - Metalloproteinase KW - Databases KW - Embryogenesis KW - Ionizing radiation KW - Neurons KW - Titration KW - Neurotoxicity KW - Crystal structure KW - Calorimetry KW - Embryos KW - Botulinum toxin KW - pharmacophores KW - N3 11008:Neurochemistry KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19862688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Inhibition+of+Metalloprotease+Botulinum+Serotype+A+from+a+Pseudo-peptide+Binding+Mode+to+a+Small+Molecule+That+Is+Active+in+Primary+Neurons&rft.au=Burnett%2C+James+C%3BRuthel%2C+Gordon%3BStegmann%2C+Christian+M%3BPanchal%2C+Rekha+G%3BNguyen%2C+Tam+L%3BHermone%2C+Ann+R%3BStafford%2C+Robert+G%3BLane%2C+Douglas+J%3BKenny%2C+Tara+A%3BMcGrath%2C+Connor+F%3BWipf%2C+Peter%3BStahl%2C+Andrea+M%3BSchmidt%2C+James+J%3BGussio%2C+Rick%3BBrunger%2C+Axel+T%3BBavari%2C+Sina&rft.aulast=Burnett&rft.aufirst=James&rft.date=2007-02-01&rft.volume=282&rft.issue=7&rft.spage=5004&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Light chains; Serotypes; Solvents; Enzymes; Botulinum toxin type A; Mines; Cancer; Metalloproteinase; Databases; Embryogenesis; Neurons; Ionizing radiation; Neurotoxicity; Titration; Crystal structure; Calorimetry; Embryos; Botulinum toxin; pharmacophores ER - TY - JOUR T1 - The Nuclease A-Inhibitor Complex Is Characterized by a Novel Metal Ion Bridge AN - 19856392; 7288542 AB - Nonspecific, extracellular nucleases have received enhanced attention recently as a consequence of the critical role that these enzymes can play in infectivity by overcoming the host neutrophil defense system. The activity of the cyanobacterial nuclease NucA, a member of the beta beta alpha Me superfamily, is controlled by the specific nuclease inhibitor, NuiA. Here we report the 2.3-Aa resolution crystal structure of the NucA-NuiA complex, showing that NucA inhibition by NuiA involves an unusual divalent metal ion bridge that connects the nuclease with its inhibitor. The C-terminal Thr-135 sub(NuiA) hydroxyl oxygen is directly coordinated with the catalytic Mg super(2+) of the nuclease active site, and Glu-24 sub(NuiA) also extends into the active site, mimicking the charge of a scissile phosphate. NuiA residues Asp-75 and Trp-76 form a second interaction site, contributing to the strength and specificity of the interaction. The crystallographically defined interface is shown to be consistent with results of studies using site-directed NuiA mutants. This mode of inhibition differs dramatically from the exosite mechanism of inhibition seen with the DNase colicins E7/E9 and from other nuclease-inhibitor complexes that have been studied. The structure of this complex provides valuable insights for the development of inhibitors for related nonspecific nucleases that share the DRGH active site motif such as the Streptococcus pneumoniae nuclease EndA, which mediates infectivity of this pathogen, and mitochondrial EndoG, which is involved in recombination and apoptosis. JF - Journal of Biological Chemistry AU - Ghosh, Mahua AU - Meiss, Gregor AU - Pingoud, Alfred M AU - London, Robert E AU - Pedersen, Lars C AD - Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 and Institut fuer Biochemie (FB 08), Justus-Liebig-Universitaet, Heinrich-Buff-Ring 58, D-35392 Giessen, Germany Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 5682 EP - 5690 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 8 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Mimicry KW - Metals KW - Apoptosis KW - colicin E7 KW - Leukocytes (neutrophilic) KW - Enzymes KW - Mitochondria KW - Nuclease KW - Pathogens KW - Nuia KW - Oxygen KW - Recombination KW - Streptococcus pneumoniae KW - Infectivity KW - Phosphate KW - Crystal structure KW - Deoxyribonuclease KW - Magnesium KW - J 02310:Genetics & Taxonomy KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=The+Nuclease+A-Inhibitor+Complex+Is+Characterized+by+a+Novel+Metal+Ion+Bridge&rft.au=Ghosh%2C+Mahua%3BMeiss%2C+Gregor%3BPingoud%2C+Alfred+M%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Ghosh&rft.aufirst=Mahua&rft.date=2007-02-01&rft.volume=282&rft.issue=8&rft.spage=5682&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metals; Mimicry; Apoptosis; colicin E7; Leukocytes (neutrophilic); Nuclease; Mitochondria; Enzymes; Pathogens; Recombination; Oxygen; Infectivity; Phosphate; Crystal structure; Deoxyribonuclease; Magnesium; Streptococcus pneumoniae; Nuia ER - TY - JOUR T1 - Characterization, Kinetics, and Crystal Structures of Fructose-1,6-bisphosphate Aldolase from the Human Parasite, Giardia lamblia AN - 19856347; 7288453 AB - Class I and class II fructose-1,6-bisphosphate aldolases (FBPA), glycolytic pathway enzymes, exhibit no amino acid sequence homology and utilize two different catalytic mechanisms. The mammalian class I FBPA employs a Schiff base mechanism, whereas the human parasitic protozoan Giardia lamblia class II FBPA is a zinc-dependent enzyme. In this study, we have explored the potential exploitation of the Giardia FBPA as a drug target. First, synthesis of FBPA was demonstrated in Giardia trophozoites by using an antibody-based fluorescence assay. Second, inhibition of FBPA gene transcription in Giardia trophozoites suggested that the enzyme is necessary for the survival of the organism under optimal laboratory growth conditions. Third, two crystal structures of FBPA in complex with the transition state analog phosphoglycolohydroxamate (PGH) show that the enzyme is homodimeric and that its active site contains a zinc ion. In one crystal form, each subunit contains PGH, which is coordinated to the zinc ion through the hydroxamic acid hydroxyl and carbonyl oxygen atoms. The second crystal form contains PGH only in one subunit and the active site of the second subunit is unoccupied. Inspection of the two states of the enzyme revealed that it undergoes a conformational transition upon ligand binding. The enzyme cleaves D-fructose-1,6-bisphosphate but not D-tagatose-1,6-bisphosphate, which is a tight binding competitive inhibitor. The essential role of the active site residue Asp-83 in catalysis was demonstrated by amino acid replacement. Determinants of catalysis and substrate recognition, derived from comparison of the G. lamblia FBPA structure with Escherichia coli FBPA and with a closely related enzyme, E. coli tagatose-1,6-bisphosphate aldolase (TBPA), are described. JF - Journal of Biological Chemistry AU - Galkin, Andrey AU - Kulakova, Liudmila AU - Melamud, Eugene AU - Li, Ling AU - Wu, Chun AU - Mariano, Patrick AU - Dunaway-Mariano, Debra AU - Nash, Theodore E AU - Herzberg, Osnat AD - Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, Rockville, Maryland 20850, the Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131, and Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 4859 EP - 4867 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 7 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Fluorescence KW - Growth conditions KW - Fructose-1,6-diphosphate KW - Giardia lamblia KW - Enzymes KW - Transcription KW - Survival KW - Crystals KW - Hydroxamic acid KW - Oxygen KW - Homology KW - Kinetics KW - Zinc KW - Escherichia coli KW - Crystal structure KW - Drugs KW - Glycolysis KW - carbonyls KW - Amino acid sequence KW - Catalysis KW - Trophozoites KW - K 03330:Biochemistry KW - N 14815:Nucleotide Sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Characterization%2C+Kinetics%2C+and+Crystal+Structures+of+Fructose-1%2C6-bisphosphate+Aldolase+from+the+Human+Parasite%2C+Giardia+lamblia&rft.au=Galkin%2C+Andrey%3BKulakova%2C+Liudmila%3BMelamud%2C+Eugene%3BLi%2C+Ling%3BWu%2C+Chun%3BMariano%2C+Patrick%3BDunaway-Mariano%2C+Debra%3BNash%2C+Theodore+E%3BHerzberg%2C+Osnat&rft.aulast=Galkin&rft.aufirst=Andrey&rft.date=2007-02-01&rft.volume=282&rft.issue=7&rft.spage=4859&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; Fluorescence; Fructose-1,6-diphosphate; Growth conditions; Survival; Transcription; Enzymes; Crystals; Hydroxamic acid; Oxygen; Homology; Kinetics; Zinc; Crystal structure; carbonyls; Glycolysis; Drugs; Trophozoites; Catalysis; Amino acid sequence; Giardia lamblia; Escherichia coli ER - TY - JOUR T1 - Elucidation of the Role of Peptide Linker in Calcium-sensing Receptor Activation Process AN - 19854718; 7288503 AB - Family 3 G-protein-coupled receptors (GPCRs), which includes metabotropic glutamate receptors (mGluRs), sweet and "umami" taste receptors (T1Rs), and the extracellular calcium-sensing receptor (CaR), represent a distinct group among the superfamily of GPCRs characterized by large amino-terminal extracellular ligand-binding domains (ECD) with homology to bacterial periplasmic amino acid-binding proteins that are responsible for signal detection and receptor activation through as yet unresolved mechanism(s) via the seven-transmembrane helical domain (7TMD) common to all GPCRs. To address the mechanism(s) by which ligand-induced conformational changes are conveyed from the ECD to the 7TMD for G-protein activation, we altered the length and composition of a 14-amino acid linker segment common to all family 3 GPCRs except GABA sub(B) receptor, in the CaR by insertion, deletion, and site-directed mutagenesis of specific highly conserved residues. Small alterations in the length and composition of the linker impaired cell surface expression and abrogated signaling of the chimeric receptors. The exchange of nine amino acids within the linker of CaR with the homologous sequence of mGluR1, however, preserved receptor function. Ala substitution for the four highly conserved residues within this amino acid sequence identified a Leu at position 606 of the CaR critical for cell surface expression and signaling. Substitution of Leu super(606) for Ala resulted in impaired cell surface expression. However, Ile and Val substitutions displayed strong activating phenotypes. Disruption of the linker by insertion of nine amino acids of a random-coiled structure uncoupled the ECD from regulating the 7TMD. These data are consistent with a model of receptor activation in which the peptide linker, and particularly Leu super(606), provides a critical interaction for the CaR signal transmission, a finding likely to be relevant for all family 3 GPCRs containing this conserved motif. JF - Journal of Biological Chemistry AU - Ray, Kausik AU - Adipietro, Kaylin A AU - Chen, Claudia AU - Northup, John K AD - Laboratory of Cellular Biology, NIDCD, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 5310 EP - 5317 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 8 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Calcium & Calcified Tissue Abstracts; Chemoreception Abstracts KW - Site-directed mutagenesis KW - Cell surface KW - Glutamic acid receptors (metabotropic) KW - Sweet taste KW - Amino acid substitution KW - Data processing KW - Receptor mechanisms KW - double prime G protein-coupled receptors KW - Guanine nucleotide-binding protein KW - Calcium (extracellular) KW - Taste receptors KW - G protein-coupled receptors KW - Homology KW - Insertion KW - Umami KW - gamma -Aminobutyric acid B receptors KW - Calcium-sensing receptors KW - Conserved sequence KW - Amino acid sequence KW - Signal transduction KW - J 02310:Genetics & Taxonomy KW - T 2000:Cellular Calcium KW - N 14815:Nucleotide Sequence KW - R 18001:Taste UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Elucidation+of+the+Role+of+Peptide+Linker+in+Calcium-sensing+Receptor+Activation+Process&rft.au=Ray%2C+Kausik%3BAdipietro%2C+Kaylin+A%3BChen%2C+Claudia%3BNorthup%2C+John+K&rft.aulast=Ray&rft.aufirst=Kausik&rft.date=2007-02-01&rft.volume=282&rft.issue=8&rft.spage=5310&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; Cell surface; Sweet taste; Glutamic acid receptors (metabotropic); Data processing; Amino acid substitution; Receptor mechanisms; double prime G protein-coupled receptors; Guanine nucleotide-binding protein; Calcium (extracellular); Taste receptors; Homology; G protein-coupled receptors; Insertion; Umami; Calcium-sensing receptors; gamma -Aminobutyric acid B receptors; Conserved sequence; Signal transduction; Amino acid sequence ER - TY - JOUR T1 - Pathogenesis of Aspergillus fumigatus and the Kinetics of Galactomannan in an In Vitro Model of Early Invasive Pulmonary Aspergillosis: Implications for Antifungal Therapy AN - 19850040; 7265301 AB - Background. Little is known about the pathogenesis of invasive pulmonary aspergillosis and the relationship between the kinetics of diagnostic markers and the outcome of antifungal therapy. Methods. An in vitro model of the human alveolus, consisting of a bilayer of human alveolar epithelial and endothelial cells, was developed. An Aspergillus fumigatus strain expressing green fluorescent protein was used. Invasion of the cell bilayer was studied using confocal and electron microscopy. The kinetics of culture, polymerase chain reaction, and galactomannan were determined. Galactomannan was used to measure the antifungal effect of macrophages and amphotericin B. A mathematical model was developed, and results were bridged to humans. Results. A. fumigatus penetrated the cellular bilayer 14-16 h after inoculation. Galactomannan levels were inextricably tied to fungal invasion and were a robust measure of the antifungal effect of macrophages and amphotericin B. Neither amphotericin nor macrophages alone was able to suppress the growth of A. fumigatus; rather, the combination was required. Monte Carlo simulations showed that human dosages of amphotericin B of at least 0.6 mg/kg were required to achieve adequate drug exposure. Conclusions. This model provides a strategy by which relationships among pathogenesis, immunological effectors, and antifungal drug therapy for invasive pulmonary aspergillosis may be further understood. JF - Journal of Infectious Diseases AU - Hope, W W AU - Kruhlak, MJ AU - Lyman, CA AU - Petraitiene, R AU - Petraitis, V AU - Francesconi, A AU - Kasai, M AU - Mickiene, D AU - Sein, T AU - Peter, J AU - Kelaher, A M AU - Hughes, JE AU - Cotton, M P AU - Cotten, C J AD - Immunocompromised Host Section, Pediatric Oncology Branch, and Experimental Immunology Branch, National Cancer Institute, and Veterinary Resources Program, Office of Research Services, National Institutes of Health, Bethesda, SAIC-Frederick, Inc., Frederick, and Department of Biology, University of Maryland, College Park, Maryland, USA Y1 - 2007/02/01/ PY - 2007 DA - 2007 Feb 01 SP - 455 EP - 466 VL - 195 IS - 3 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Monte Carlo simulation KW - Macrophages KW - Amphotericin B KW - Mathematical models KW - Green fluorescent protein KW - Cell culture KW - Aspergillosis KW - Alveoli KW - Endothelial cells KW - Lung KW - Aspergillus fumigatus KW - Kinetics KW - Inoculation KW - Polymerase chain reaction KW - Drugs KW - Electron microscopy KW - K 03410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850040?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Pathogenesis+of+Aspergillus+fumigatus+and+the+Kinetics+of+Galactomannan+in+an+In+Vitro+Model+of+Early+Invasive+Pulmonary+Aspergillosis%3A+Implications+for+Antifungal+Therapy&rft.au=Hope%2C+W+W%3BKruhlak%2C+MJ%3BLyman%2C+CA%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BFrancesconi%2C+A%3BKasai%2C+M%3BMickiene%2C+D%3BSein%2C+T%3BPeter%2C+J%3BKelaher%2C+A+M%3BHughes%2C+JE%3BCotton%2C+M+P%3BCotten%2C+C+J&rft.aulast=Hope&rft.aufirst=W&rft.date=2007-02-01&rft.volume=195&rft.issue=3&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Monte Carlo simulation; Amphotericin B; Mathematical models; Green fluorescent protein; Aspergillosis; Cell culture; Alveoli; Endothelial cells; Lung; Kinetics; Inoculation; Polymerase chain reaction; Drugs; Electron microscopy; Aspergillus fumigatus ER - TY - JOUR T1 - The Pregnane X Receptor Gene-Humanized Mouse: A Model for Investigating Drug-Drug Interactions Mediated by Cytochromes P450 3A AN - 19848698; 7251868 AB - The most common clinical implication for the activation of the human pregnane X receptor (PXR) is the occurrence of drug-drug interactions mediated by up-regulated cytochromes P450 3A (CYP3A) isozymes. Typical rodent models do not predict drug-drug interactions mediated by human PXR because of species differences in response to PXR ligands. In the current study, a PXR-humanized mouse model was generated by bacterial artificial chromosome (BAC) transgenesis in Pxr-null mice using a BAC clone containing the complete human PXR gene and 5'- and 3'-flanking sequences. In this PXR-humanized mouse model, PXR is selectively expressed in the liver and intestine, the same tissue expression pattern as CYP3A. Treatment of PXR-humanized mice with the PXR ligands mimicked the human response, since both hepatic and intestinal CYP3As were strongly induced by rifampicin, a human-specific PXR ligand, but not by pregnenolone 16 alpha -carbonitrile, a rodent-specific PXR ligand. In rifampicin-pretreated PXR-humanized mice, an similar to 60% decrease was observed for both the maximal midazolam serum concentration (C sub(max)) and the area under the concentration-time curve, as a result of a 3-fold increase in midazolam 1'-hydroxylation. These results illustrate the potential utility of the PXR-humanized mice in the investigation of drug-drug interactions mediated by CYP3A and suggest that the PXR-humanized mouse model would be an appropriate in vivo tool for evaluation of the overall pharmacokinetic consequences of human PXR activation by drugs. JF - Drug Metabolism and Disposition AU - Ma, Xiaochao AU - Shah, Yatrik AU - Cheung, Connie AU - Guo, Grace L AU - Feigenbaum, Lionel AU - Krausz, Kristopher W AU - Idle, Jeffrey R AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (X.M., Y.S., C.C., K.W.K., F.J.G.) Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 194 EP - 200 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 35 IS - 2 SN - 0090-9556, 0090-9556 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Toxicology Abstracts KW - Animal models KW - Pharmacokinetics KW - Bacterial artificial chromosomes KW - midazolam KW - Rifampin KW - Liver KW - Intestine KW - Pregnenolone KW - Isoenzymes KW - Cytochrome P450 KW - pregnane X receptors KW - Drugs KW - J 02410:Animal Diseases KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=The+Pregnane+X+Receptor+Gene-Humanized+Mouse%3A+A+Model+for+Investigating+Drug-Drug+Interactions+Mediated+by+Cytochromes+P450+3A&rft.au=Ma%2C+Xiaochao%3BShah%2C+Yatrik%3BCheung%2C+Connie%3BGuo%2C+Grace+L%3BFeigenbaum%2C+Lionel%3BKrausz%2C+Kristopher+W%3BIdle%2C+Jeffrey+R%3BGonzalez%2C+Frank+J&rft.aulast=Ma&rft.aufirst=Xiaochao&rft.date=2007-02-01&rft.volume=35&rft.issue=2&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - midazolam; Bacterial artificial chromosomes; Rifampin; Isoenzymes; Animal models; Pregnenolone; Intestine; Liver; pregnane X receptors; Cytochrome P450; Drugs; Pharmacokinetics ER - TY - JOUR T1 - Fetal Onset of Aberrant Gene Expression Relevant to Pulmonary Carcinogenesis in Lung Adenocarcinoma Development Induced by In Utero Arsenic Exposure AN - 19846560; 7255645 AB - Arsenic is a human pulmonary carcinogen. Our work indicates that in utero arsenic exposure in mice can induce or initiate lung cancer in female offspring. To define early molecular changes, pregnant C3H mice were given 85 ppm arsenic in drinking water from days 8 to 18 of gestation and expression of selected genes in the fetal lung or in lung tumors developing in adults was examined. Transplacental arsenic exposure increased estrogen receptor- alpha (ER- alpha ) transcript and protein levels in the female fetal lung. An overexpression of various estrogen-regulated genes also occurred, including trefoil factor-3, anterior gradient-2, and the steroid metabolism genes 17-{szligbeta}-hydroxysteroid dehydrogenase type 5 and aromatase. The insulin growth factor system, which can be influenced by ER and has been implicated in the pulmonary oncogenic process, was activated in fetal lung after gestational arsenic exposure. In utero arsenic exposure also induced overexpression of alpha -fetoprotein, epidermal growth factor receptor, L-myc, and metallothionein-1 in fetal lung, all of which are associated with lung cancer. Lung adenoma and adenocarcinoma from adult female mice exposed to arsenic in utero showed widespread, intense nuclear ER- alpha expression. In contrast, normal adult lung and diethylnitrosamine-induced lung adenocarcinoma showed little evidence of ER- alpha expression. Thus, transplacental arsenic exposure at a carcinogenic dose produced aberrant estrogen-linked pulmonary gene expression. ER- alpha activation was specifically associated with arsenic-induced lung adenocarcinoma and adenoma but not with nitrosamine-induced lung tumors. These data provide evidence that arsenic-induced aberrant ER signaling could disrupt early life stage genetic programing in the lung leading eventually to lung tumor formation much later in adulthood. JF - Toxicological Sciences AU - Shen, Jun AU - Liu, Jie AU - Xie, Yaxiong AU - Diwan, Bhalchandra A AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. Basic Research Program, Science Applications International Corp. at Frederick, National Cancer Institute, Frederick, Maryland Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 313 EP - 320 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 95 IS - 2 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Pollution Abstracts; Toxicology Abstracts KW - alpha -fetoprotein KW - tumors KW - Epidermal growth factor receptors KW - steroids KW - Carcinogens KW - dehydrogenase KW - Insulin KW - Gene expression KW - Aromatase KW - Carcinogenicity KW - Gestation KW - growth factors KW - offspring KW - Lung cancer KW - Arsenic KW - Data processing KW - insulin KW - Transcription KW - Developmental stages KW - Mice KW - Steroid hormones KW - Tumors KW - Intrauterine exposure KW - Cancer KW - Fetuses KW - Pregnancy KW - Carcinogenesis KW - Proteins KW - Progeny KW - Adenocarcinoma KW - Drinking water KW - Estrogen receptors KW - Adenoma KW - Metabolism KW - estrogens KW - Signal transduction KW - P 2000:FRESHWATER POLLUTION KW - X 24360:Metals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19846560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Fetal+Onset+of+Aberrant+Gene+Expression+Relevant+to+Pulmonary+Carcinogenesis+in+Lung+Adenocarcinoma+Development+Induced+by+In+Utero+Arsenic+Exposure&rft.au=Shen%2C+Jun%3BLiu%2C+Jie%3BXie%2C+Yaxiong%3BDiwan%2C+Bhalchandra+A%3BWaalkes%2C+Michael+P&rft.aulast=Shen&rft.aufirst=Jun&rft.date=2007-02-01&rft.volume=95&rft.issue=2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - alpha -fetoprotein; Epidermal growth factor receptors; Carcinogens; Insulin; dehydrogenase; Gene expression; Aromatase; Gestation; Lung cancer; Arsenic; Data processing; Developmental stages; Transcription; Intrauterine exposure; Tumors; Steroid hormones; Fetuses; Pregnancy; Carcinogenesis; Progeny; Drinking water; Adenocarcinoma; Adenoma; Estrogen receptors; Metabolism; Signal transduction; insulin; tumors; Mice; steroids; Cancer; Carcinogenicity; Proteins; growth factors; estrogens; offspring ER - TY - JOUR T1 - Chemoprevention of rat prostate carcinogenesis by dietary 16 alpha -fluoro-5-androsten-17-one (fluasterone), a minimally androgenic analog of dehydroepiandrosterone AN - 19838359; 7286846 AB - Dehydroepiandrosterone (DHEA) is a potent inhibitor of prostate carcinogenesis in rats. However, concerns related to the possible androgenicity of DHEA may preclude its use for chemoprevention of human prostate cancer. Studies were performed to compare the androgenicity of DHEA and a fluorinated DHEA analog, 16 alpha -fluoro-5-androsten-17-one (fluasterone), and to determine the chemopreventive activity of fluasterone in the rat prostate. Comparisons of accessory sex gland weight and histology in gonadectomized male rats demonstrated that fluasterone is less androgenic than is DHEA. Fluasterone conferred significant protection against prostate carcinogenesis induced in Wistar-Unilever rats by a sequential regimen of N-methyl-N-nitrosourea + testosterone. Chronic administration of fluasterone at levels of 2000 and 1000 mg/kg diet reduced the incidence of adenocarcinoma in the dorsolateral/anterior prostate from 64% in dietary controls to 28 and 31%, respectively. Other than a dose-related suppression of body weight gain, chronic exposure to fluasterone induced no clinical evidence of toxicity; suppression of body weight gain may be either a pharmacological effect or a minimally toxic effect of the compound. These data demonstrate that a minimally androgenic analog of DHEA protects against prostate carcinogenesis induced in rats by a chemical carcinogen + androgen. The reduced androgenicity of fluasterone may obviate toxicities associated with the androgenicity of the parent compound. On this basis, fluasterone merits consideration for evaluation in clinical trials for prostate cancer prevention. The chemopreventive activity of a non-androgenic DHEA analog suggests that at least a portion of the chemopreventive activity of DHEA in the rat prostate is unrelated to hormonal effects. JF - Carcinogenesis AU - McCormick, David L AU - Johnson, William D AU - Kozub, Nicole M AU - Rao, KVN AU - Lubet, Ronald A AU - Steele, Vernon E AU - Bosland, Maarten C AD - Life Sciences Group, IIT Research Institute Chicago, IL 60616, USA. Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute Bethesda, MD 20892, USA. Department of Environmental Medicine and Urology, New York University School of Medicine New York, NY 10016, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 398 EP - 403 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 2 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - Diets KW - Data processing KW - Dehydroepiandrosterone KW - Toxicity KW - N-Methyl-N-nitrosourea KW - Carcinogens KW - Clinical trials KW - Testosterone KW - Prostate cancer KW - Chronic exposure KW - Glands KW - Carcinogenesis KW - Adenocarcinoma KW - Body weight gain KW - Sex KW - Androgens KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Chemoprevention+of+rat+prostate+carcinogenesis+by+dietary+16+alpha+-fluoro-5-androsten-17-one+%28fluasterone%29%2C+a+minimally+androgenic+analog+of+dehydroepiandrosterone&rft.au=McCormick%2C+David+L%3BJohnson%2C+William+D%3BKozub%2C+Nicole+M%3BRao%2C+KVN%3BLubet%2C+Ronald+A%3BSteele%2C+Vernon+E%3BBosland%2C+Maarten+C&rft.aulast=McCormick&rft.aufirst=David&rft.date=2007-02-01&rft.volume=28&rft.issue=2&rft.spage=398&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Diets; Data processing; Dehydroepiandrosterone; Carcinogens; N-Methyl-N-nitrosourea; Toxicity; Clinical trials; Testosterone; Prostate cancer; Chronic exposure; Glands; Carcinogenesis; Body weight gain; Adenocarcinoma; Androgens; Sex ER - TY - JOUR T1 - Automatic 3D tracking of cardiac material markers using slice-following and harmonic-phase MRI AN - 19804369; 8585727 AB - A method to track a grid of cardiac material points in three dimensions using slice-following (SF) tagged magnetic resonance imaging (MRI) and harmonic-phase MRI is presented. A three-dimensional grid of material points on the lines of intersections of short-axis (SA) and long-axis (LA) planes is automatically tracked by combining two-dimensional pathlines that are computed on both SA and la image planes. This process yields the true three-dimensional motion of points originating on the image plane intersections. Experimental data from normal volunteers, each obtained in four short breath-holds using the SF harmonic phase MRI pulse sequence, is presented. A validation of two-dimensional in-plane tracks using this pulse sequence on a moving phantom is also presented. JF - Magnetic Resonance Imaging AU - Sampath, Smita AU - Prince, Jerry L AD - Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA, sampaths@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 197 EP - 208 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 2 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts KW - Magnetic resonance tagging KW - HARP KW - Slice-following KW - Cardiac motion KW - Cardiac strain KW - Heart KW - Data processing KW - Magnetic resonance imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Automatic+3D+tracking+of+cardiac+material+markers+using+slice-following+and+harmonic-phase+MRI&rft.au=Sampath%2C+Smita%3BPrince%2C+Jerry+L&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2007-02-01&rft.volume=25&rft.issue=2&rft.spage=197&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2006.09.033 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Data processing; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.mri.2006.09.033 ER - TY - JOUR T1 - Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs AN - 19741767; 7640435 AB - DNA plasmids and recombinant adenovirus serotype-5 (rAd5) vectors are being studied in human clinical trials as HIV-1 vaccine candidates. Each elicits robust T-cell responses and modest antibody levels. Since protein immunization alone elicits antibody but not CD8 T-cell responses, we studied protein boosting of DNA and rAd5 HIV-1 vaccine vectors. A single Env protein immunization provided a marked boost in antibody titer in guinea pigs primed with either DNA or rAd5 vaccines, and the resulting antibody binding and neutralization levels were similar to those attained after thee sequential protein immunizations. Since both T-cell immunity and neutralizing antibodies are thought to be required for protection against HIV-1, it may be possible to establish a balanced T-cell and antibody response with appropriate vectored vaccines and improve the neutralizing antibody titer with protein boosting. JF - Vaccine AU - Shu, Yuuei AU - Winfrey, Sarah AU - Yang, Zhi-yong AU - Xu, Ling AU - Rao, Srinivas S AU - Srivastava, Indresh AU - Barnett, Susan W AU - Nabel, Gary J AU - Mascola, John R AD - Vaccine Research Center, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, United States, jmascola@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1398 EP - 1408 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 8 SN - 0264-410X, 0264-410X KW - Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - HIV KW - Neutralizing antibodies KW - Adjuvant KW - Adenovirus KW - CD8 antigen KW - Immunity KW - Antibody response KW - Plasmids KW - Clinical trials KW - Immunization KW - Expression vectors KW - DNA vaccines KW - Human immunodeficiency virus 1 KW - Envelope protein KW - Lymphocytes T KW - Vaccines KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19741767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Efficient+protein+boosting+after+plasmid+DNA+or+recombinant+adenovirus+immunization+with+HIV-1+vaccine+constructs&rft.au=Shu%2C+Yuuei%3BWinfrey%2C+Sarah%3BYang%2C+Zhi-yong%3BXu%2C+Ling%3BRao%2C+Srinivas+S%3BSrivastava%2C+Indresh%3BBarnett%2C+Susan+W%3BNabel%2C+Gary+J%3BMascola%2C+John+R&rft.aulast=Shu&rft.aufirst=Yuuei&rft.date=2007-02-01&rft.volume=25&rft.issue=8&rft.spage=1398&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.10.046 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Expression vectors; DNA vaccines; Envelope protein; Lymphocytes T; Antibody response; Immunity; CD8 antigen; Vaccines; Plasmids; Clinical trials; Immunization; Human immunodeficiency virus 1; Adenovirus DO - http://dx.doi.org/10.1016/j.vaccine.2006.10.046 ER - TY - JOUR T1 - Long-Lasting Decrease in Viremia in Macaques Chronically Infected with Simian Immunodeficiency Virus SIVmac251 after Therapeutic DNA Immunization AN - 19735648; 7254034 AB - Rhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P = 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy. JF - Journal of Virology AU - von Gegerfelt, Agneta S AU - Rosati, Margherita AU - Alicea, Candido AU - Valentin, Antonio AU - Roth, Patricia AU - Bear, Jenifer AU - Franchini, Genoveffa AU - Albert, Paul S AU - Bischofberger, Norbert AU - Boyer, Jean D AU - Weiner, David B AU - Markham, Phillip AU - Israel, Zimra R AU - Eldridge, John H AU - Pavlakis, George N AU - Felber, Barbara K AD - Human Retrovirus Section. Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702. Animal Models and Retroviral Vaccines Section, Vaccine Branch, Center for Cancer Research. Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892. Gilead Sciences, Foster City, California 94404. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104. Advanced BioSciences Laboratories, Inc., Kensington, Maryland 20895. Wyeth Vaccines Research, Pearl River, New York 10965 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1972 EP - 1979 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 81 IS - 4 SN - 0022-538X, 0022-538X KW - Rhesus macaque KW - Rhesus monkey KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - DNA vaccines KW - Antiviral agents KW - antiretroviral therapy KW - DNA KW - Macaca mulatta KW - Viremia KW - Vaccination KW - Immunosuppressive agents KW - Simian immunodeficiency virus KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - N 14845:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Long-Lasting+Decrease+in+Viremia+in+Macaques+Chronically+Infected+with+Simian+Immunodeficiency+Virus+SIVmac251+after+Therapeutic+DNA+Immunization&rft.au=von+Gegerfelt%2C+Agneta+S%3BRosati%2C+Margherita%3BAlicea%2C+Candido%3BValentin%2C+Antonio%3BRoth%2C+Patricia%3BBear%2C+Jenifer%3BFranchini%2C+Genoveffa%3BAlbert%2C+Paul+S%3BBischofberger%2C+Norbert%3BBoyer%2C+Jean+D%3BWeiner%2C+David+B%3BMarkham%2C+Phillip%3BIsrael%2C+Zimra+R%3BEldridge%2C+John+H%3BPavlakis%2C+George+N%3BFelber%2C+Barbara+K&rft.aulast=von+Gegerfelt&rft.aufirst=Agneta&rft.date=2007-02-01&rft.volume=81&rft.issue=4&rft.spage=1972&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antiviral agents; DNA vaccines; antiretroviral therapy; DNA; Viremia; Immunosuppressive agents; Vaccination; Macaca mulatta; Simian immunodeficiency virus ER - TY - JOUR T1 - NCI Thesaurus: A semantic model integrating cancer-related clinical and molecular information AN - 19728567; 7504508 AB - Over the last 8 years, the National Cancer Institute (NCI) has launched a major effort to integrate molecular and clinical cancer-related information within a unified biomedical informatics framework, with controlled terminology as its foundational layer. The NCI Thesaurus is the reference terminology underpinning these efforts. It is designed to meet the growing need for accurate, comprehensive, and shared terminology, covering topics including: cancers, findings, drugs, therapies, anatomy, genes, pathways, cellular and subcellular processes, proteins, and experimental organisms. The NCI Thesaurus provides a partial model of how these things relate to each other, responding to actual user needs and implemented in a deductive logic framework that can help maintain the integrity and extend the informational power of what is provided. This paper presents the semantic model for cancer diseases and its uses in integrating clinical and molecular knowledge, more briefly examines the models and uses for drug, biochemical pathway, and mouse terminology, and discusses limits of the current approach and directions for future work. JF - Journal of Biomedical Informatics AU - Sioutos, Nicholas AU - de Coronado, Sherri AU - Haber, Margaret W AU - Hartel, Frank W AU - Shaiu, Wen-Ling AU - Wright, Lawrence W AD - Aspen Systems Corporation, USA, decorons@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 30 EP - 43 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 40 IS - 1 SN - 1532-0464, 1532-0464 KW - Biotechnology and Bioengineering Abstracts KW - Biomedical vocabulary KW - Ontology development KW - Cancer research KW - Disease model KW - Cancer terminology KW - Molecular modelling KW - Animal models KW - Bioinformatics KW - Drugs KW - Cancer KW - Semantics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19728567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomedical+Informatics&rft.atitle=NCI+Thesaurus%3A+A+semantic+model+integrating+cancer-related+clinical+and+molecular+information&rft.au=Sioutos%2C+Nicholas%3Bde+Coronado%2C+Sherri%3BHaber%2C+Margaret+W%3BHartel%2C+Frank+W%3BShaiu%2C+Wen-Ling%3BWright%2C+Lawrence+W&rft.aulast=Sioutos&rft.aufirst=Nicholas&rft.date=2007-02-01&rft.volume=40&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomedical+Informatics&rft.issn=15320464&rft_id=info:doi/10.1016%2Fj.jbi.2006.02.013 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Animal models; Bioinformatics; Drugs; Cancer; Semantics DO - http://dx.doi.org/10.1016/j.jbi.2006.02.013 ER - TY - JOUR T1 - Dectin-1 promotes fungicidal activity of human neutrophils AN - 19727274; 7515713 AB - Human polymorphonuclear leukocytes (PMN) are a first line of defense against fungal infections. PMN express numerous pattern recognition receptors (PRR) that facilitate identification of invading microorganisms and ultimately promote resolution of disease. Dectin-1 (-glucan receptor) is a PRR expressed on several cell types and has been studied on monocytes and macrophages. However, the role played by dectin-1 in the recognition and killing of fungi by PMN is unknown. We investigated the ability of dectin-1 to mediate human PMN phagocytosis and fungicidal activity. Dectin-1 was expressed on the surface of PMN from all subjects tested (n=29) and in an intracellular compartment that co-sedimented with azurophilic granules in Percoll density gradients. Soluble -glucan and mAb GE2 (anti-dectin-1) inhibited binding and phagocytosis of zymosan by human PMN (e.g., ingestion was inhibited 40.1% by 30min, p<0.001), and blocked reactive oxygen species production. Notably, soluble -glucan and GE2 inhibited phagocytosis and killing of Candida albicans by PMN (inhibition of killing was 54.8% for -glucan and 36.2% for GE2, p<0.01). Our results reveal a mechanism whereby PMN dectin-1 plays a key role in the recognition and killing of fungal pathogens by the innate immune system. JF - European Journal of Immunology AU - Kennedy, Adam D AU - Willment, Janet A AU - Dorward, David W AU - Williams, David L AU - Brown, Gordon D AU - Deleo, Frank R AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA, fdeleo@niaid.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 467 EP - 478 PB - Wiley-VCH, Postfach 101161 Weinheim 69451 Germany, [mailto:info@wiley-vch.de], [URL:http://www.wiley-vch.de/publish/en/] VL - 37 IS - 2 SN - 0014-2980, 0014-2980 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Immunology Abstracts KW - Macrophages KW - Granules KW - Monoclonal antibodies KW - Immune system KW - Leukocytes (polymorphonuclear) KW - Fungi KW - Fungicidal activity KW - Leukocytes (neutrophilic) KW - Candida albicans KW - Pathogens KW - Infection KW - Pattern recognition KW - Density gradients KW - Reactive oxygen species KW - Microorganisms KW - Monocytes KW - Phagocytosis KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - K 03350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Immunology&rft.atitle=Dectin-1+promotes+fungicidal+activity+of+human+neutrophils&rft.au=Kennedy%2C+Adam+D%3BWillment%2C+Janet+A%3BDorward%2C+David+W%3BWilliams%2C+David+L%3BBrown%2C+Gordon+D%3BDeleo%2C+Frank+R&rft.aulast=Kennedy&rft.aufirst=Adam&rft.date=2007-02-01&rft.volume=37&rft.issue=2&rft.spage=467&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Immunology&rft.issn=00142980&rft_id=info:doi/10.1002%2Feji.200636653 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Granules; Macrophages; Monoclonal antibodies; Fungi; Leukocytes (polymorphonuclear); Immune system; Fungicidal activity; Leukocytes (neutrophilic); Pathogens; Infection; Pattern recognition; Reactive oxygen species; Density gradients; Microorganisms; Monocytes; Phagocytosis; Candida albicans DO - http://dx.doi.org/10.1002/eji.200636653 ER - TY - JOUR T1 - Assessment by Cardiovascular Magnetic Resonance, Electron Beam Computed Tomography, and Carotid Ultrasonography of the Distribution of Subclinical Atherosclerosis Across Framingham Risk Strata AN - 19722599; 7512097 AB - Screening for subclinical atherosclerosis has been advocated for individuals at intermediate global risk for coronary heart disease (CHD). However, the distribution of subclinical atherosclerosis test values across CHD risk strata is unknown. We studied a stratified random sample of 292 participants (mean age 59.5 years, 50% women) from the offspring cohort of the Framingham Heart Study who were free of clinically apparent cardiovascular disease. We assessed abdominal and thoracic aortic plaque burden by cardiovascular magnetic resonance (CMR), coronary artery calcification (CAC) and thoracic aortic calcification (TAC) by electron beam computed tomography, and common carotid intima-media thickness (C-IMT) by ultrasonography. We categorized the upper 20% of each measurement as a high level of atherosclerosis and evaluated these variables across clinically relevant Framingham CHD risk score strata (low, intermediate, and high risk). In age-adjusted analyses in men and women, correlations across CMR aortic plaque, CAC, TAC, and C-IMT were low (maximum r = 0.30 for CAC:TAC in women, p =2 measurements. However, different participants were identified as having high atherosclerosis by each modality. For example, in a comparison of the overlap across CMR aortic plaque, CAC, and C-IMT, only 4% of men and 16% of women were classified as having high atherosclerosis on all 3 measurements. In conclusion, in a community-based sample, correlations among subclinical atherosclerosis test results are low, and a substantial proportion has high levels of subclinical atherosclerosis detected on >=2 imaging tests. JF - American Journal of Cardiology AU - Kathiresan, Sekar AU - Scd, Martin G Larson AU - Keyes, Michelle J AU - Polak, Joseph F AU - Wolf, Philip A AU - D'Agostino, Ralph B AU - Jaffer, Farouc A AU - Clouse, Melvin E AU - Levy, Daniel AU - Manning, Warren J AU - O'Donnell, Christopher J AD - Framingham Heart Study, Framingham, Massachusetts, codonell@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 310 EP - 314 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 99 IS - 3 SN - 0002-9149, 0002-9149 KW - Biotechnology and Bioengineering Abstracts KW - Risk assessment KW - Age KW - Aorta KW - Calcification (ectopic) KW - Arteriosclerosis KW - imaging KW - Ultrasonography KW - Coronary heart disease KW - coronary artery KW - Risk factors KW - Computed tomography KW - Thorax KW - Progeny KW - N.M.R. KW - Plaques KW - Cardiovascular diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19722599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Cardiology&rft.atitle=Assessment+by+Cardiovascular+Magnetic+Resonance%2C+Electron+Beam+Computed+Tomography%2C+and+Carotid+Ultrasonography+of+the+Distribution+of+Subclinical+Atherosclerosis+Across+Framingham+Risk+Strata&rft.au=Kathiresan%2C+Sekar%3BScd%2C+Martin+G+Larson%3BKeyes%2C+Michelle+J%3BPolak%2C+Joseph+F%3BWolf%2C+Philip+A%3BD%27Agostino%2C+Ralph+B%3BJaffer%2C+Farouc+A%3BClouse%2C+Melvin+E%3BLevy%2C+Daniel%3BManning%2C+Warren+J%3BO%27Donnell%2C+Christopher+J&rft.aulast=Kathiresan&rft.aufirst=Sekar&rft.date=2007-02-01&rft.volume=99&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Cardiology&rft.issn=00029149&rft_id=info:doi/10.1016%2Fj.amjcard.2006.08.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Arteriosclerosis; Aorta; Plaques; Ultrasonography; Calcification (ectopic); N.M.R.; Computed tomography; Risk factors; Thorax; imaging; Progeny; Risk assessment; Coronary heart disease; Cardiovascular diseases; coronary artery; Age DO - http://dx.doi.org/10.1016/j.amjcard.2006.08.028 ER - TY - JOUR T1 - Tarantula toxins interacting with voltage sensors in potassium channels AN - 19707919; 7477359 AB - Voltage-activated ion channels open and close in response to changes in membrane voltage, a process that is crucial for electrical signaling in the nervous system. The venom from many poisonous creatures contains a diverse array of small protein toxins that bind to voltage-activated channels and modify the gating mechanism. Hanatoxin and a growing number of related tarantula toxins have been shown to inhibit activation of voltage-activated potassium (K sub(v)) channels by interacting with their voltage-sensing domains. This review summarizes our current understanding of the mechanism by which these toxins alter gating, the location of the toxin receptor within K sub(v) channels and the disposition of this receptor with respect to the lipid membrane. The conservation of tarantula toxin receptors among voltage-activated ion channels will also be discussed. JF - Toxicon AU - Swartz, K J AD - Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, swartzk@ninds.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 213 EP - 230 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 49 IS - 2 SN - 0041-0101, 0041-0101 KW - Spiders KW - Entomology Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - Channel gating KW - Disposition KW - Toxins KW - Nervous system KW - Lipid membranes KW - Reviews KW - Protein arrays KW - Ion channels KW - Potassium channels (voltage-gated) KW - Conservation KW - Araneae KW - Venom KW - Potassium channels KW - Signal transduction KW - X 24370:Natural Toxins KW - N3 11028:Neuropharmacology & toxicology KW - Z 05320:Physiology, Anatomy, and Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19707919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicon&rft.atitle=Tarantula+toxins+interacting+with+voltage+sensors+in+potassium+channels&rft.au=Swartz%2C+K+J&rft.aulast=Swartz&rft.aufirst=K&rft.date=2007-02-01&rft.volume=49&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Toxicon&rft.issn=00410101&rft_id=info:doi/10.1016%2Fj.toxicon.2006.09.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Channel gating; Disposition; Toxins; Nervous system; Lipid membranes; Reviews; Ion channels; Protein arrays; Potassium channels (voltage-gated); Conservation; Potassium channels; Venom; Signal transduction; Araneae DO - http://dx.doi.org/10.1016/j.toxicon.2006.09.024 ER - TY - JOUR T1 - Persistent bacterial infections and primary immune disorders AN - 19668779; 7424458 AB - Mycobacteria, Salmonella and Helicobacter species have all evolved mechanisms to evade host defenses and cause persistent infection in humans. Host control of mycobacteria and Salmonella is largely achieved by the IFN-/IL-12 pathway. Immune disorders affecting this pathway are characterized by disseminated infections with environmental or nontuberculous mycobacteria. Helicobacter is a predominantly extracellular bacterium that uses its remarkable genetic diversity (as well as other mechanisms) in order to evade host defenses. The importance of humoral immunity in containing Helicobacter infections to the mucosal surface is illustrated by the primary immune disorder, X-linked agammaglobulinemia in which patients are prone to chronic bacteremia and skin infections by Helicobacter and related species such as Flexispira and Campylobacter. Exploration of these particular infections in their specific immune defects sheds light on both host and bacterial mechanisms that have implications for pathogenesis and therapy. JF - Current Opinion in Microbiology AU - Freeman, Alexandra F AU - Holland, Steven M AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1684, USA, smh@nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 70 EP - 75 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 10 IS - 1 SN - 1369-5274, 1369-5274 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Bacteria KW - Skin KW - Helicobacter KW - Mucosa KW - Disseminated infection KW - Campylobacter KW - Bacteremia KW - Genetic diversity KW - Persistent infection KW - Immunity (humoral) KW - Interleukin 12 KW - Interferon KW - Reviews KW - X-linked agammaglobulinemia KW - Chronic infection KW - Salmonella KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19668779?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Microbiology&rft.atitle=Persistent+bacterial+infections+and+primary+immune+disorders&rft.au=Freeman%2C+Alexandra+F%3BHolland%2C+Steven+M&rft.aulast=Freeman&rft.aufirst=Alexandra&rft.date=2007-02-01&rft.volume=10&rft.issue=1&rft.spage=70&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Microbiology&rft.issn=13695274&rft_id=info:doi/10.1016%2Fj.mib.2006.11.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Immunity (humoral); Interferon; Interleukin 12; Skin; X-linked agammaglobulinemia; Reviews; Disseminated infection; Mucosa; Chronic infection; Genetic diversity; Bacteremia; Persistent infection; Bacteria; Helicobacter; Campylobacter; Salmonella DO - http://dx.doi.org/10.1016/j.mib.2006.11.005 ER - TY - JOUR T1 - Plasma concentrations of free triiodothyronine predict weight change in euthyroid persons AN - 19666857; 7427649 AB - Background: Factors that influence energy metabolism and substrate oxidation, such as thyroid hormones (THs), may be important regulators of body weight. Objective: We investigated associations of THs cross-sectionally with obesity, energy expenditure, and substrate oxidation and prospectively with weight change. Design: Euthyroid, nondiabetic, healthy, adult Pima Indians (n = 89; 47 M, 42 F) were studied. Percentage body fat (%BF) was measured by using dual-energy X-ray absorptiometry; sleeping metabolic rate (SMR), respiratory quotient, and substrate oxidation rates were measured in a respiratory chamber. Thyroid-stimulating hormone (TSH), free thyroxine (T sub(4)), free triiodothyronine (T sub(3)), and leptin concentrations were measured in fasting plasma samples. Results: TSH, but neither free T sub(3) nor free T sub(4), was associated with %BF and leptin concentrations (r = 0.27 and 0.29, respectively; both: P less than or equal to 0.01). In multiple regression analyses adjusted for age, sex, fat mass, and fat-free mass, free T sub(3) was a positive predictor of SMR (P = 0.02). After adjustment for age, sex, %BF, and energy balance, free T sub(3) was a negative predictor of 24-h respiratory quotient (P < 0.05) and a positive predictor of 24-h lipid oxidation rate (P = 0.006). Prospectively, after an average follow-up of 4 plus or minus 2 y, the mean increase in weight was 3 plus or minus 9 kg. Baseline T sub(3) concentrations were associated with absolute and annual percentage of changes in weight (r = -0.27, P = 0.02, and r = -0.28, P = 0.009, for the age- and sex-adjusted associations, respectively). Conclusions: In euthyroid Pima Indians, lower free T sub(3) but not free T sub(4) concentrations were an independent predictor of SMR and lipid oxidation and a predictor of weight gain. This finding indicates that control of T sub(4)-to-T sub(3) conversion may play a role in body weight regulation. JF - American Journal of Clinical Nutrition AU - Ortega, E AU - Pannacciulli, N AU - Bogardus, C AU - Krakoff, J AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiological Clinical and Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Phoenix, AZ, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 440 EP - 445 VL - 85 IS - 2 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Obesity KW - Measurement KW - Lipids KW - Health KW - Adults KW - Nutrition KW - Hormones KW - X-Ray KW - Energy cost KW - Weight KW - Analysis KW - Metabolism KW - Ethnic groups KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19666857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Clinical+Nutrition&rft.atitle=Plasma+concentrations+of+free+triiodothyronine+predict+weight+change+in+euthyroid+persons&rft.au=Ortega%2C+E%3BPannacciulli%2C+N%3BBogardus%2C+C%3BKrakoff%2C+J&rft.aulast=Ortega&rft.aufirst=E&rft.date=2007-02-01&rft.volume=85&rft.issue=2&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Lipids; Health; Adults; Hormones; Nutrition; Energy cost; X-Ray; Weight; Analysis; Ethnic groups; Metabolism; Sex ER - TY - JOUR T1 - Determination and Analysis of Site-Specific super(125)I Decay-Induced DNA Double-Strand Break End-Group Structures AN - 19654715; 7410711 AB - End groups contribute to the structural complexity of radiation-induced DNA double-strand breaks (DSBs). As such, end-group structures may affect a cell's ability to repair DSBs. The 3'-end groups of strand breaks caused by gamma radiation, or oxidative processes, under oxygenated aqueous conditions have been shown to be distributed primarily between 3'-phosphoglycolate and 3'-phosphate, with 5'-phosphate ends in both cases. In this study, end groups of the high-LET-like DSBs caused by super(125)I decay were investigated. Site-specific DNA double-strand breaks were produced in plasmid pTC27 in the presence or absence of 2 M DMSO by super(125)I-labeled triplex-forming oligonucleotide targeting. End-group structure was assessed enzymatically as a function of the DSB end to serve as a substrate for ligation and various forms of end labeling. Using this approach, we have demonstrated 3'-hydroxyl (3'-OH) and 3'-phosphate (3'-P) end groups and 5'-ends ( greater than or equal to 42%) terminated by phosphate. A super(32)P postlabeling assay failed to detect 3'-phosphoglycolate in a restriction fragment terminated by the super(125)I-induced DNA double-strand break, and this is likely due to restricted oxygen diffusion during irradiation as a frozen aqueous solution. Even so, end-group structure and relative distribution varied as a function of the free radical scavenging capacity of the irradiation buffer. JF - Radiation Research AU - Datta, K AU - Weinfeld, M AU - Neumann, R D AU - Winters, T A AD - Nuclear Medicine Department Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 152 EP - 166 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 167 IS - 2 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - DNA damage KW - Oxygen KW - Phosphate KW - Free radicals KW - gamma Radiation KW - Diffusion KW - Plasmids KW - Oligonucleotides KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19654715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Determination+and+Analysis+of+Site-Specific+super%28125%29I+Decay-Induced+DNA+Double-Strand+Break+End-Group+Structures&rft.au=Datta%2C+K%3BWeinfeld%2C+M%3BNeumann%2C+R+D%3BWinters%2C+T+A&rft.aulast=Datta&rft.aufirst=K&rft.date=2007-02-01&rft.volume=167&rft.issue=2&rft.spage=152&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0629.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=167&issue=2&page=152 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Oxygen; DNA damage; Phosphate; Free radicals; gamma Radiation; Diffusion; Plasmids; Oligonucleotides DO - http://dx.doi.org/10.1667/RR0629.1 ER - TY - JOUR T1 - A Cell-Based Assay for I Kappa B alpha Stabilization Using a Two-Color Dual Luciferase-Based Sensor AN - 19625794; 7361114 AB - A cell-sensor assay for stabilization of I Kappa B alpha was developed in the activated B cell-like diffuse large B-cell lymphoma cell line OCI-Ly3. This cell line expresses known nuclear factor Kappa B (NF Kappa B) target genes due to high constitutive activity of I Kappa B kinase (IKK), which phosphorylates the protein I Kappa B alpha leading to proteasomal degradation of I Kappa B alpha and activation of NF Kappa B. The cell-sensor assay uses green and red light-emitting beetle luciferases, with the green luciferase fused to I Kappa B alpha (I Kappa B alpha -CBG68) and the red luciferase (CBR) present in its native state. The I Kappa B alpha -CBG68 reporter functions as a sensor of IKK and proteasome activity, while CBR serves to normalize for cell number and nonspecific effects. Both reporter constructs were stably integrated and placed under the control of an inducible promoter system, which increased fold responsiveness to inhibitors when assay incubations were performed simultaneous to reporter induction by doxycycline. The assay was miniaturized to a 1,536-well plate format and showed a Z' of 0.6; it was then used to panel 2,677 bioactive compounds by a concentration-response-based screening strategy. The concentration-effect curves for the I Kappa B alpha -CBG68 and CBR signals were then used to identify specific stabilizers of I Kappa B alpha , such as IKK inhibitors or proteasome inhibitors, which increased the doxycycline-induced rise in I Kappa B alpha -CBG68 without affecting the rise in CBR. Known and unexpected inhibitors of NF Kappa B signaling were identified from the bioactive collection. We describe here the development and performance of this assay, and discuss the merits of its specific features. JF - Assay and Drug Development Technologies AU - Davis, R E AU - Zhang, Y-Q AU - Southall, N AU - Staudt, L M AU - Austin, C P AU - Inglese, J AU - Auld, D S AD - NIH Chemical Genomics Center National Human Genome Research Institute National Institutes of Health 9800 Medical Center Drive Bethesda, MD 20892-3370, USA, dauld@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 85 EP - 103 VL - 5 IS - 1 SN - 1540-658X, 1540-658X KW - Biotechnology and Bioengineering Abstracts KW - double prime B-cell lymphoma KW - Cell number KW - Lymphocytes B KW - proteasomes KW - Drug development KW - IKK protein KW - Promoters KW - I Kappa B kinase KW - Tumor cell lines KW - Doxycycline KW - proteasome inhibitors KW - Signal transduction KW - W 30955:Biosensors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19625794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Assay+and+Drug+Development+Technologies&rft.atitle=A+Cell-Based+Assay+for+I+Kappa+B+alpha+Stabilization+Using+a+Two-Color+Dual+Luciferase-Based+Sensor&rft.au=Davis%2C+R+E%3BZhang%2C+Y-Q%3BSouthall%2C+N%3BStaudt%2C+L+M%3BAustin%2C+C+P%3BInglese%2C+J%3BAuld%2C+D+S&rft.aulast=Davis&rft.aufirst=R&rft.date=2007-02-01&rft.volume=5&rft.issue=1&rft.spage=85&rft.isbn=&rft.btitle=&rft.title=Assay+and+Drug+Development+Technologies&rft.issn=1540658X&rft_id=info:doi/10.1089%2Fadt.2006.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - I Kappa B kinase; Promoters; Tumor cell lines; double prime B-cell lymphoma; Cell number; Lymphocytes B; proteasomes; Drug development; IKK protein; proteasome inhibitors; Doxycycline; Signal transduction DO - http://dx.doi.org/10.1089/adt.2006.048 ER - TY - JOUR T1 - Neural correlates of response reversal: Considering acquisition AN - 19618254; 7345973 AB - Previous work on response reversal has typically used a single pair of stimuli that serially reverse. This conflation of acquisition and reversal processes has prevented an examination of the functional role of neural systems implicated in response reversal during acquisition despite the relevance of such data in evaluating accounts of response reversal. In the current study, participants encountered 16 independent reversing stimulus pairs in the context of a probabilistic response reversal paradigm. Functional regions of interest identified as involved in response reversal through a contrast used in the previous literature (punished errors made in the reversal phase versus rewarded correct responses), were interrogated across conditions. Consistent with suggestions that middle frontal cortex codes reward, this region showed significantly greater responses to rewarded rather than punished trials irrespective of accuracy or learning phase (acquisition or reversal). Consistent with the suggestion that this coding of the expectation of reinforcement is acquired via input from the amygdala, we observed significant positive connectivity between activity within the amygdala and a region of rostral anterior cingulate cortex highly proximal to this region of middle frontal/mesial prefrontal cortex. In contrast, inferior frontal cortex, anterior cingulate cortex and caudate showed greater responses to punished errors than to the rewarded correct responses. These three regions also showed significant activation to rewarded errors during acquisition, in contrast to positions suggesting that inferior frontal cortex represents punishment or suppresses previously rewarded responses. Moreover, a connectivity analysis with an anterior cingulate cortex seed revealed highly significant positive connectivity among them. The implications of these data for recent accounts of response reversal and of response reversal impairments in specific neuropsychiatric populations are discussed. JF - NeuroImage AU - Budhani, S AU - Marsh, A A AU - Pine, D S AU - Blair, RJR AD - Department of Psychology, University College London, London WC1E 6BT, UK, James.Blair@mail.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1754 EP - 1765 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Caudate KW - Anterior cingulate KW - Probabilistic reversal learning KW - Psychopathy KW - Inferior frontal cortex KW - Coding KW - Learning KW - Seeds KW - Neural networks KW - Punishment KW - Reinforcement KW - Cortex (frontal) KW - Amygdala KW - Cortex (prefrontal) KW - Cortex (cingulate) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19618254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+correlates+of+response+reversal%3A+Considering+acquisition&rft.au=Budhani%2C+S%3BMarsh%2C+A+A%3BPine%2C+D+S%3BBlair%2C+RJR&rft.aulast=Budhani&rft.aufirst=S&rft.date=2007-02-01&rft.volume=34&rft.issue=4&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.08.060 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Coding; Seeds; Learning; Neural networks; Punishment; Reinforcement; Cortex (frontal); Amygdala; Cortex (cingulate); Cortex (prefrontal) DO - http://dx.doi.org/10.1016/j.neuroimage.2006.08.060 ER - TY - JOUR T1 - Imaging signal transduction via arachidonic acid in the human brain during visual stimulation, by means of positron emission tomography AN - 19615562; 7345934 AB - 6 months [OR = 1.95; 95% confidence interval (95% CI) = 1.09-3.51]. Excluding pregnancies after 13+ months resulted in a loss of precision (OR = 2.14; 95% CI = 0.90-5.04). CONCLUSIONS: These data support higher fecundity among mothers of multiples than mothers of singletons. JF - Human Reproduction AU - Ferrari, R M AU - Cooney, MA AU - Vexler, A AU - Liu, A AU - Buck Louis, GM AD - Department of Maternal and Child Health, University of North Carolina at Chapel Hill, Chapel Hill, NC. Epidemiology Branch and. Biometry Branch, National Institute of Child Health and Human Development, Rockville, MD, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 407 EP - 413 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 2 SN - 0268-1161, 0268-1161 KW - Sustainability Science Abstracts KW - fecundity KW - Reproduction KW - Pregnancy KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19538371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Time+to+pregnancy+and+multiple+births&rft.au=Ferrari%2C+R+M%3BCooney%2C+MA%3BVexler%2C+A%3BLiu%2C+A%3BBuck+Louis%2C+GM&rft.aulast=Ferrari&rft.aufirst=R&rft.date=2007-02-01&rft.volume=22&rft.issue=2&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - fecundity; Reproduction; Pregnancy ER - TY - JOUR T1 - Prevention of Immune Cell Apoptosis as Potential Therapeutic Strategy for Severe Infections AN - 19526944; 7828851 AB - Some labile cell types whose numbers are normally controiled through programmed cell death are subject to markedly increased destruction during some severe infections. Lymphocytes, in particular, undergo massive and apparently unregulated apoptosis in human patients and laboratory animals with sepsis, potentially playing a major role in the severe immunosuppression that characterizes the terminal phase of fatal illness. Extensive lymphocyte apoptosis has also occurred in humans and animals infected with several exotic agents, including Bacillus anthracis, the cause of anthrax; Yersinia pestis, the cause of plague; and Ebola virus. Prevention of lymphocyte apoptosis, through either genetic modification of the host or treatment with specific inhibitors, markedly improves survival in murine sepsis models. These findings suggest that interventions aimed at reducing the extent of immune cell apoptosis could improve outcomes for a variety of severe human infections, including those caused by emerging pathogens and bioterrorism agents. JF - Emerging Infectious Diseases AU - Parrlno, J AU - Hotchklss, R S AU - Bray, M AD - National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 VL - 13 IS - 2 SN - 1080-6040, 1080-6040 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Cell survival KW - Apoptosis KW - bioterrorism KW - Animal models KW - Laboratory animals KW - Yersinia pestis KW - Ebola virus KW - Lymphocytes KW - Pathogens KW - Bacillus anthracis KW - Infection KW - Sepsis KW - Anthrax KW - Plague KW - Immunosuppression KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19526944?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Emerging+Infectious+Diseases&rft.atitle=Prevention+of+Immune+Cell+Apoptosis+as+Potential+Therapeutic+Strategy+for+Severe+Infections&rft.au=Parrlno%2C+J%3BHotchklss%2C+R+S%3BBray%2C+M&rft.aulast=Parrlno&rft.aufirst=J&rft.date=2007-02-01&rft.volume=13&rft.issue=2&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Emerging+Infectious+Diseases&rft.issn=10806040&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Cell survival; Sepsis; Apoptosis; bioterrorism; Laboratory animals; Animal models; Anthrax; Plague; Pathogens; Lymphocytes; Infection; Immunosuppression; Yersinia pestis; Ebola virus; Bacillus anthracis ER - TY - JOUR T1 - Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells AN - 19514142; 7230305 AB - Telomerase plays an important role in the maintenance of telomere ends in normal and tumor cells and ectopic expression can immortalize human bronchial epithelial (HBE) cells. We assessed telomerase activation, growth properties and methylation status in the hTERT promoter in a panel of HBE cell cultures in relation to smoking and previous lung cancer history. HBE cells were obtained from a total of 26 subjects, six of whom were lifelong non-smokers, while 20 subjects had a smoking history, including seven who had lung carcinoma. Telomerase activity was determined using the telomeric repeat amplification protocol (TRAP). Maximum passage number and time to senescence were also determined through extended culturing. The distribution of the telomerase activity between ever-smokers and never-smokers was significantly different (P=0.03, F-test), and there was a strong correlation between telomerase activity and the number of pack-years smoked (P=0.0012, F-test for slope). A small difference in telomerase activity was observed according to lung cancer status (P=0.02, F-test). Telomerase activity was not correlated with maximum passage number after extended culturing or with time to senescence. None of the HBE cultures demonstrated methylation of the hTERT promoter. Our results indicate an association between tobacco carcinogen exposure and telomerase activity in normal bronchial epithelium, although a causative role of tobacco smoking in the (re)activation of telomerase can not be proven. An increase in telomerase activity in normal bronchial epithelium might extend the lifespan of cells at risk for malignant transformation, and thus contribute to lung carcinogenesis. JF - Cancer Letters AU - Yim, Hyeon Woo AU - Slebos, Robbert JC AU - Randell, Scott H AU - Umbach, David M AU - Parsons, Alden M AU - Rivera, MPatricia AU - Detterbeck, Frank C AU - Taylor, Jack A AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA, taylor@niehs.nih.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 24 EP - 33 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 246 IS - 1-2 SN - 0304-3835, 0304-3835 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Telomerase activity KW - Bronchial epithelial cells KW - Smoking KW - Risk assessment KW - Transformation KW - Epithelial cells KW - Tobacco smoking KW - Lung carcinoma KW - Life span KW - Cell culture KW - Carcinogens KW - Tumor cells KW - Telomeres KW - Promoters KW - Carcinogenesis KW - Acid phosphatase (tartrate-resistant) KW - DNA methylation KW - Epithelium KW - Senescence KW - Telomerase reverse transcriptase KW - Lung cancer KW - X 24380:Social Poisons & Drug Abuse KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19514142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Smoking+is+associated+with+increased+telomerase+activity+in+short-term+cultures+of+human+bronchial+epithelial+cells&rft.au=Yim%2C+Hyeon+Woo%3BSlebos%2C+Robbert+JC%3BRandell%2C+Scott+H%3BUmbach%2C+David+M%3BParsons%2C+Alden+M%3BRivera%2C+MPatricia%3BDetterbeck%2C+Frank+C%3BTaylor%2C+Jack+A&rft.aulast=Yim&rft.aufirst=Hyeon&rft.date=2007-02-01&rft.volume=246&rft.issue=1-2&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2006.01.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Risk assessment; Tobacco smoking; Epithelial cells; Lung carcinoma; Life span; Cell culture; Carcinogens; Tumor cells; Promoters; Telomeres; Carcinogenesis; DNA methylation; Acid phosphatase (tartrate-resistant); Senescence; Epithelium; Telomerase reverse transcriptase; Lung cancer DO - http://dx.doi.org/10.1016/j.canlet.2006.01.023 ER - TY - JOUR T1 - Data mining of NCIs anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines AN - 19491756; 7185601 AB - Mitochondria are principal mediators of apoptosis and thus can be considered molecular targets for new chemotherapeutic agents in the treatment of cancer. Inhibitors of mitochondrial complex I of the electron transport chain have been shown to induce apoptosis and exhibit antitumor activity. In an effort to find novel complex I inhibitors which exhibited anticancer activity in the NCIs tumor cell line screen, we examined organized tumor cytotoxicity screening data available as SOM (self-organized maps) (http://www.spheroid.ncifcrf.gov) at the developmental therapeutics program (DTP) of the National Cancer Institute (NCI). Our analysis focused on an SOM cluster comprised of compounds which included a number of known mitochondrial complex I (NADH:CoQ oxidoreductase) inhibitors. From these clusters 10 compounds whose mechanism of action was unknown were tested for inhibition of complex I activity in bovine heart sub-mitochondrial particles (SMP) resulting in the discovery that 5 of the 10 compounds demonstrated significant inhibition with IC sub(50)s in the nM range for three of the five. Examination of screening profiles of the five inhibitors toward the NCIs tumor cell lines revealed that they were cytotoxic to the leukemia subpanel (particularly K562 cells). Oxygen consumption experiments with permeabilized K562 cells revealed that the five most active compounds inhibited complex I activity in these cells in the same rank order and similar potency as determined with bovine heart SMP. Our findings thus fortify the appeal of mitochondrial complex I as a possible anticancer molecular target and provide a data mining strategy for selecting candidate inhibitors for further testing. JF - Biochemical Pharmacology AU - Glover, Constance J AU - Rabow, Alfred A AU - Isgor, Yasemin G AU - Shoemaker, Robert H AU - Covell, David G AD - Developmental Therapeutics Program, National Cancer Institute at Frederick, Frederick, MD 21702, United States, cglover@mail.ncifcrf.gov Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 331 EP - 340 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 73 IS - 3 SN - 0006-2952, 0006-2952 KW - Biotechnology and Bioengineering Abstracts KW - Oxygen consumption KW - Heart KW - Apoptosis KW - Data processing KW - Chemotherapy KW - Mitochondria KW - Tumors KW - Cancer KW - Databases KW - Cytotoxicity KW - Tumor cell lines KW - oxidoreductase KW - NADH-ubiquinone oxidoreductase KW - Electron transport chain KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491756?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+Pharmacology&rft.atitle=Data+mining+of+NCIs+anticancer+screening+database+reveals+mitochondrial+complex+I+inhibitors+cytotoxic+to+leukemia+cell+lines&rft.au=Glover%2C+Constance+J%3BRabow%2C+Alfred+A%3BIsgor%2C+Yasemin+G%3BShoemaker%2C+Robert+H%3BCovell%2C+David+G&rft.aulast=Glover&rft.aufirst=Constance&rft.date=2007-02-01&rft.volume=73&rft.issue=3&rft.spage=331&rft.isbn=&rft.btitle=&rft.title=Biochemical+Pharmacology&rft.issn=00062952&rft_id=info:doi/10.1016%2Fj.bcp.2006.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - NADH-ubiquinone oxidoreductase; Tumor cell lines; Cytotoxicity; Data processing; Cancer; Heart; Apoptosis; Antitumor activity; Electron transport chain; Mitochondria; Oxygen consumption; oxidoreductase; Databases; Tumors; Chemotherapy DO - http://dx.doi.org/10.1016/j.bcp.2006.10.005 ER - TY - JOUR T1 - Effects of Friedreich's ataxia (GAA) sub(n).(TTC) sub(n) repeats on RNA synthesis and stability AN - 19452290; 7408709 AB - Expansions of (GAA) sub(n) repeats within the first intron of the frataxin gene reduce its expression, resulting in a hereditary neurodegenerative disorder, Friedreich's ataxia. While it is generally believed that expanded (GAA) sub(n) repeats block transcription elongation, fine mechanisms responsible for gene repression are not fully understood. To follow the effects of (GAA) sub(n).(TTC) sub(n) repeats on gene expression, we have chosen E. coli as a convenient model system. (GAA) sub(n).(TTC) sub(n) repeats were cloned into bacterial plasmids in both orientations relative to a promoter, and their effects on transcription and RNA stability were evaluated both in vitro and in vivo. Expanded (GAA) sub(n) repeats in the sense strand for transcription caused a significant decrease in the mRNA levels in vitro and in vivo. This decrease was likely due to the tardiness of the RNA polymerase within expanded (GAA) sub(n) runs but was not accompanied by the enzyme's dissociation and premature transcription termination. Unexpectedly, positioning of normal- and carrier-size (TTC) sub(n) repeats into the sense strand for transcription led to the appearance of RNA transcripts that were truncated within those repetitive runs in vivo. We have determined that these RNA truncations are consistent with cleavage of the full-sized mRNAs at (UUC) sub(n) runs by the E. coli degradosome. JF - Nucleic Acids Research AU - Krasilnikova, Maria M AU - Kireeva, Maria L AU - Petrovic, Vladimir AU - Knijnikova, Nelli AU - Kashlev, Mikhail AU - Mirkin, Sergei M AD - Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA, NCI Center for Cancer Research, Frederick, MD 21702, USA and Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 1075 EP - 1084 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 IS - 4 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; CSA Neurosciences Abstracts KW - Transcription termination KW - Transcription KW - Plasmids KW - Sensory systems KW - frataxin KW - Friedreich's ataxia KW - Gene expression KW - Neurodegenerative diseases KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription elongation KW - Escherichia coli KW - Introns KW - Gene silencing KW - J 02310:Genetics & Taxonomy KW - N3 11023:Neurogenetics KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19452290?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Effects+of+Friedreich%27s+ataxia+%28GAA%29+sub%28n%29.%28TTC%29+sub%28n%29+repeats+on+RNA+synthesis+and+stability&rft.au=Krasilnikova%2C+Maria+M%3BKireeva%2C+Maria+L%3BPetrovic%2C+Vladimir%3BKnijnikova%2C+Nelli%3BKashlev%2C+Mikhail%3BMirkin%2C+Sergei+M&rft.aulast=Krasilnikova&rft.aufirst=Maria&rft.date=2007-02-01&rft.volume=35&rft.issue=4&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transcription termination; Transcription; Plasmids; Sensory systems; Friedreich's ataxia; frataxin; Gene expression; Promoters; Neurodegenerative diseases; DNA-directed RNA polymerase; Transcription elongation; Introns; Gene silencing; Escherichia coli ER - TY - JOUR T1 - Pesticide Exposure and Self-reported Parkinson's Disease in the Agricultural Health Study AN - 19442228; 7285901 AB - Previous studies based on limited exposure assessment have suggested that Parkinson's disease (PD) is associated with pesticide exposure. The authors used data obtained from licensed private pesticide applicators and spouses participating in the Agricultural Health Study to evaluate the relation of self-reported PD to pesticide exposure. Cohort members, who were enrolled in 1993-1997, provided detailed information on lifetime pesticide use. At follow-up in 1999-2003, 68% of the cohort was interviewed. Cases were defined as participants who reported physician-diagnosed PD at enrollment (prevalent cases, n = 83) or follow-up (incident cases, n = 78). Cases were compared with cohort members who did not report PD (n = 79,557 at enrollment and n = 55,931 at follow-up). Incident PD was associated with cumulative days of pesticide use at enrollment (for highest quartile vs. lowest, odds ratio (OR) = 2.3, 95% confidence interval: 1.2, 4.5; p-trend = 0.009), with personally applying pesticides more than half the time (OR = 1.9, 95% confidence interval: 0.7, 4.7), and with some specific pesticides (ORs greater than or equal to 1.4). Prevalent PD was not associated with overall pesticide use. This study suggests that exposure to certain pesticides may increase PD risk. Findings for specific chemicals may provide fruitful leads for further investigation. JF - American Journal of Epidemiology AU - Kamel, F AU - Tanner, C M AU - Umbach, D M AU - Hoppin, JA AU - Alavanja, MCR AU - Blair, A AU - Comyns, K AU - Goldman, S M AU - Korell, M AU - Langston, J W AU - Ross, G W AU - Sandler, D P AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 364 EP - 374 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 4 SN - 0002-9262, 0002-9262 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Health & Safety Science Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Neurodegenerative diseases KW - Movement disorders KW - Data processing KW - Parkinson's disease KW - Pesticides KW - Agrochemicals KW - A 01380:Plant Protection, Fungicides & Seed Treatments KW - H 5000:Pesticides KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19442228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Pesticide+Exposure+and+Self-reported+Parkinson%27s+Disease+in+the+Agricultural+Health+Study&rft.au=Kamel%2C+F%3BTanner%2C+C+M%3BUmbach%2C+D+M%3BHoppin%2C+JA%3BAlavanja%2C+MCR%3BBlair%2C+A%3BComyns%2C+K%3BGoldman%2C+S+M%3BKorell%2C+M%3BLangston%2C+J+W%3BRoss%2C+G+W%3BSandler%2C+D+P&rft.aulast=Kamel&rft.aufirst=F&rft.date=2007-02-01&rft.volume=165&rft.issue=4&rft.spage=364&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Neurodegenerative diseases; Data processing; Movement disorders; Parkinson's disease; Pesticides; Agrochemicals ER - TY - JOUR T1 - A generic protocol for the expression and purification of recombinant proteins in Escherichia coli using a combinatorial His sub(6)-maltose binding protein fusion tag AN - 1439237980; 18477334 AB - We describe a generic protocol for the overproduction and purification of recombinant proteins in Escherichia coli. The strategy utilizes a dual His sub(6)-maltose binding protein (HisMBP) affinity tag that can be removed from the target protein by digestion of the fusion protein at a designed site by tobacco etch virus protease. The MBP moiety serves to enhance the solubility and promote the proper folding of its fusion partners, and the polyhistidine tag facilitates its purification to homogeneity. This protocol is divided into three stages, each of which takes approximately 1 week to complete: (i) construction of a HisMBP fusion vector; (ii) a pilot experiment to assess the yield and solubility of the target protein; and (iii) the large-scale production and purification of the target protein. JF - Nature Protocols AU - Nallamsetty, Sreedevi AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, Maryland 21702-1201, USA. Y1 - 2007/02// PY - 2007 DA - Feb 2007 SP - 383 EP - 391 PB - Nature Publishing Group, The Macmillan Building London N1 9XW United Kingdom VL - 2 IS - 2 SN - 1750-2799, 1750-2799 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Solubility KW - Escherichia coli KW - Tobacco etch virus KW - Proteinase KW - protein purification KW - Fusion protein KW - polyhistidine KW - J 02420:Plant Diseases KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1439237980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Protocols&rft.atitle=A+generic+protocol+for+the+expression+and+purification+of+recombinant+proteins+in+Escherichia+coli+using+a+combinatorial+His+sub%286%29-maltose+binding+protein+fusion+tag&rft.au=Nallamsetty%2C+Sreedevi%3BWaugh%2C+David+S&rft.aulast=Nallamsetty&rft.aufirst=Sreedevi&rft.date=2007-02-01&rft.volume=2&rft.issue=2&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Nature+Protocols&rft.issn=17502799&rft_id=info:doi/10.1038%2Fnprot.2007.50 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2013-10-01 N1 - Last updated - 2013-12-16 N1 - SubjectsTermNotLitGenreText - Solubility; Proteinase; Fusion protein; protein purification; polyhistidine; Escherichia coli; Tobacco etch virus DO - http://dx.doi.org/10.1038/nprot.2007.50 ER - TY - CPAPER T1 - Identification of Small RNAs Associated with the Gypsy Chromatin Insulator T2 - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AN - 39341162; 4502388 JF - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AU - Lei, Elissa Y1 - 2007/01/28/ PY - 2007 DA - 2007 Jan 28 KW - Chromatin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39341162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.atitle=Identification+of+Small+RNAs+Associated+with+the+Gypsy+Chromatin+Insulator&rft.au=Lei%2C+Elissa&rft.aulast=Lei&rft.aufirst=Elissa&rft.date=2007-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNAi and Heterochromatin Assembly in S. pombe T2 - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AN - 39303795; 4502385 JF - 2007 Keystone Symposia on MicroRNAs and siRNAs: Biological Functions and Mechanisms (J5) AU - Grewal, Shiv I S Y1 - 2007/01/28/ PY - 2007 DA - 2007 Jan 28 KW - Heterochromatin KW - RNA-mediated interference KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39303795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.atitle=RNAi+and+Heterochromatin+Assembly+in+S.+pombe&rft.au=Grewal%2C+Shiv+I+S&rft.aulast=Grewal&rft.aufirst=Shiv+I&rft.date=2007-01-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+MicroRNAs+and+siRNAs%3A+Biological+Functions+and+Mechanisms+%28J5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - A "silent" polymorphism in the MDR1 gene changes substrate specificity. AN - 68949232; 17185560 AB - Synonymous single-nucleotide polymorphisms (SNPs) do not produce altered coding sequences, and therefore they are not expected to change the function of the protein in which they occur. We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), nonetheless results in P-gp with altered drug and inhibitor interactions. Similar mRNA and protein levels, but altered conformations, were found for wild-type and polymorphic P-gp. We hypothesize that the presence of a rare codon, marked by the synonymous polymorphism, affects the timing of cotranslational folding and insertion of P-gp into the membrane, thereby altering the structure of substrate and inhibitor interaction sites. JF - Science (New York, N.Y.) AU - Kimchi-Sarfaty, Chava AU - Oh, Jung Mi AU - Kim, In-Wha AU - Sauna, Zuben E AU - Calcagno, Anna Maria AU - Ambudkar, Suresh V AU - Gottesman, Michael M AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. kimchi@cber.fda.gov Y1 - 2007/01/26/ PY - 2007 DA - 2007 Jan 26 SP - 525 EP - 528 VL - 315 IS - 5811 KW - Codon KW - 0 KW - P-Glycoprotein KW - RNA, Messenger KW - Rhodamine 123 KW - 1N3CZ14C5O KW - Cyclosporine KW - 83HN0GTJ6D KW - Verapamil KW - CJ0O37KU29 KW - Sirolimus KW - W36ZG6FT64 KW - Index Medicus KW - Animals KW - Protein Biosynthesis KW - HeLa Cells KW - Humans KW - Verapamil -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Messenger -- genetics KW - Rhodamine 123 -- pharmacology KW - Mutagenesis, Site-Directed KW - Rhodamine 123 -- metabolism KW - RNA, Messenger -- metabolism KW - Haplotypes KW - Transfection KW - Cyclosporine -- pharmacology KW - Verapamil -- metabolism KW - Sirolimus -- pharmacology KW - Cercopithecus aethiops KW - Substrate Specificity KW - Cell Membrane -- metabolism KW - Protein Structure, Tertiary KW - Cell Line KW - Protein Conformation KW - Polymorphism, Single Nucleotide KW - P-Glycoprotein -- genetics KW - P-Glycoprotein -- metabolism KW - Protein Folding KW - P-Glycoprotein -- chemistry KW - P-Glycoprotein -- antagonists & inhibitors KW - Genes, MDR UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68949232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28New+York%2C+N.Y.%29&rft.atitle=A+%22silent%22+polymorphism+in+the+MDR1+gene+changes+substrate+specificity.&rft.au=Kimchi-Sarfaty%2C+Chava%3BOh%2C+Jung+Mi%3BKim%2C+In-Wha%3BSauna%2C+Zuben+E%3BCalcagno%2C+Anna+Maria%3BAmbudkar%2C+Suresh+V%3BGottesman%2C+Michael+M&rft.aulast=Kimchi-Sarfaty&rft.aufirst=Chava&rft.date=2007-01-26&rft.volume=315&rft.issue=5811&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Science+%28New+York%2C+N.Y.%29&rft.issn=1095-9203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2007-01-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Science. 2007 Jan 26;315(5811):466-7 [17185559] Epilepsia. 2007 Dec;48(12):2369-70 [18088268] Bioessays. 2007 Jun;29(6):515-9 [17508390] Erratum In: Science. 2011 oCT 7;334(6052):39 Science. 2007 Nov 30;318(5855):1382-3 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Cardiorespiratory and SAO sub(2) Changes Precede Apnea and Bradycardia Events during Infant Home Memory Monitoring T2 - 25th Annual Conference on Sleep Disorders in Infancy and Childhood AN - 39319448; 4551962 JF - 25th Annual Conference on Sleep Disorders in Infancy and Childhood AU - Hunt, C E AU - Corwin, M J AU - Weese-Mayer, D E AU - Ward, S.L.D. AU - Lister, G AU - Neuman, M R AU - Tinsley, L R AU - Ramanathan, R AU - Willinger, M Y1 - 2007/01/25/ PY - 2007 DA - 2007 Jan 25 KW - Residential areas KW - Infants KW - Sleep disorders KW - Apnea KW - Memory KW - Bradycardia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39319448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.atitle=Cardiorespiratory+and+SAO+sub%282%29+Changes+Precede+Apnea+and+Bradycardia+Events+during+Infant+Home+Memory+Monitoring&rft.au=Hunt%2C+C+E%3BCorwin%2C+M+J%3BWeese-Mayer%2C+D+E%3BWard%2C+S.L.D.%3BLister%2C+G%3BNeuman%2C+M+R%3BTinsley%2C+L+R%3BRamanathan%2C+R%3BWillinger%2C+M&rft.aulast=Hunt&rft.aufirst=C&rft.date=2007-01-25&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Conference+on+Sleep+Disorders+in+Infancy+and+Childhood&rft.issn=&rft_id=info:doi/ L2 - http://www.5starmeded.org/sleepdisorders/abstracts.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Image-guided, direct convective delivery of glucocerebrosidase for neuronopathic Gaucher disease. AN - 68937379; 17065591 AB - To determine if convection-enhanced delivery (CED) of glucocerebrosidase could be used to treat targeted sites of disease progression in the brain and brainstem of a patient with neuronopathic Gaucher disease while monitoring enzyme distribution using MRI. A CED paradigm in rodents (n = 8) and primates (n = 5) that employs co-infusion of a surrogate MRI tracer (gadolinium diethylenetriamine penta-acetic acid [Gd-DTPA]) with glucocerebrosidase to permit real-time monitoring of distribution was developed. The safety and feasibility of this delivery and monitoring paradigm were evaluated in a patient with type 2 Gaucher disease. Animal studies revealed that real-time, T1-weighted, MRI of Gd-DTPA accurately tracked enzyme distribution during CED. Targeted perfusion of clinically affected anatomic sites in a patient with neuronopathic Gaucher disease (frontal lobe and brainstem) with glucocerebrosidase was successfully performed. Real-time MRI revealed progressive and complete filling of the targeted region with enzyme and Gd-DTPA infusate. The patient tolerated the infusions without evidence of toxicity. Convection-enhanced delivery can be used to safely perfuse large regions of the brain and brainstem with therapeutic levels of glucocerebrosidase. Co-infused imaging surrogate tracers can be used to monitor and control the distribution of therapeutic agents in vivo. Patients with neuronopathic Gaucher disease and other intrinsic CNS disorders may benefit from a similar treatment paradigm. JF - Neurology AU - Lonser, R R AU - Schiffman, R AU - Robison, R A AU - Butman, J A AU - Quezado, Z AU - Walker, M L AU - Morrison, P F AU - Walbridge, S AU - Murray, G J AU - Park, D M AU - Brady, R O AU - Oldfield, E H AD - Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bldg. 10, Rm. 5D37, Bethesda, MD 20892-1414, USA. lonserr@ninds.nih.gov Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 SP - 254 EP - 261 VL - 68 IS - 4 KW - Glucosylceramidase KW - EC 3.2.1.45 KW - Abridged Index Medicus KW - Index Medicus KW - Rats KW - Infant KW - Animals KW - Rats, Sprague-Dawley KW - Neurons -- drug effects KW - Humans KW - Macaca mulatta KW - Radiography KW - Male KW - Neurons -- pathology KW - Convection KW - Surgery, Computer-Assisted -- methods KW - Glucosylceramidase -- administration & dosage KW - Gaucher Disease -- drug therapy KW - Gaucher Disease -- diagnostic imaging KW - Gaucher Disease -- surgery UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68937379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Image-guided%2C+direct+convective+delivery+of+glucocerebrosidase+for+neuronopathic+Gaucher+disease.&rft.au=Lonser%2C+R+R%3BSchiffman%2C+R%3BRobison%2C+R+A%3BButman%2C+J+A%3BQuezado%2C+Z%3BWalker%2C+M+L%3BMorrison%2C+P+F%3BWalbridge%2C+S%3BMurray%2C+G+J%3BPark%2C+D+M%3BBrady%2C+R+O%3BOldfield%2C+E+H&rft.aulast=Lonser&rft.aufirst=R&rft.date=2007-01-23&rft.volume=68&rft.issue=4&rft.spage=254&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Retrospective Cohort Study of Cumulative False Positive Risk for Lung Cancer Screening Test Among Tin Miners in Yunnan China T2 - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AN - 39329580; 4508525 JF - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AU - Hu, Ping Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 KW - China, People's Rep. KW - Tin KW - Lung cancer KW - Occupational safety KW - Mining KW - Screening KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39329580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.atitle=Retrospective+Cohort+Study+of+Cumulative+False+Positive+Risk+for+Lung+Cancer+Screening+Test+Among+Tin+Miners+in+Yunnan+China&rft.au=Hu%2C+Ping&rft.aulast=Hu&rft.aufirst=Ping&rft.date=2007-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/emr-ibs2007/progrem.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estimation of the Discrimination Ability of Biomarkers Subject to Limit of Detection T2 - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AN - 39299922; 4508519 JF - Fourth Meeting of the Eastern Mediterranean Region of the International Biometric Society (EMR-IBS 2007) AU - Schisterman, Enrique Y1 - 2007/01/23/ PY - 2007 DA - 2007 Jan 23 KW - Bioindicators KW - Discrimination KW - Biomarkers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39299922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.atitle=Estimation+of+the+Discrimination+Ability+of+Biomarkers+Subject+to+Limit+of+Detection&rft.au=Schisterman%2C+Enrique&rft.aulast=Schisterman&rft.aufirst=Enrique&rft.date=2007-01-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fourth+Meeting+of+the+Eastern+Mediterranean+Region+of+the+International+Biometric+Society+%28EMR-IBS+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.congress.co.il/emr-ibs2007/progrem.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deletion of KIS Accelerates Intimal Hyperplasia in Response to Vascular Injury and Enhances Migratory Activity of VSMC T2 - 2007 Keystone Symposia on Integrative Basis of Cardiovascular Disease (J4) AN - 39258927; 4506243 JF - 2007 Keystone Symposia on Integrative Basis of Cardiovascular Disease (J4) AU - Langenickel, Thomas H Y1 - 2007/01/22/ PY - 2007 DA - 2007 Jan 22 KW - Injuries KW - Recruitment KW - Vascular system KW - Deletion KW - Hyperplasia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Integrative+Basis+of+Cardiovascular+Disease+%28J4%29&rft.atitle=Deletion+of+KIS+Accelerates+Intimal+Hyperplasia+in+Response+to+Vascular+Injury+and+Enhances+Migratory+Activity+of+VSMC&rft.au=Langenickel%2C+Thomas+H&rft.aulast=Langenickel&rft.aufirst=Thomas&rft.date=2007-01-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Integrative+Basis+of+Cardiovascular+Disease+%28J4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=83 2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence Variation in Human Taste Receptors T2 - 2007 Keystone Symposia on Chemical Senses: From Genes to Perception (A7) AN - 39312878; 4502477 JF - 2007 Keystone Symposia on Chemical Senses: From Genes to Perception (A7) AU - Drayna, Dennis Y1 - 2007/01/21/ PY - 2007 DA - 2007 Jan 21 KW - Taste receptors KW - Taste KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Chemical+Senses%3A+From+Genes+to+Perception+%28A7%29&rft.atitle=Sequence+Variation+in+Human+Taste+Receptors&rft.au=Drayna%2C+Dennis&rft.aulast=Drayna&rft.aufirst=Dennis&rft.date=2007-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Chemical+Senses%3A+From+Genes+to+Perception+%28A7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 3&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Translating the Basic Science of Tumor-Host Interactions into New Human Immunotherapies T2 - 2007 Keystone Symposia on Host Cell Interaction and Response to the Cancer Cell (A8) AN - 39219974; 4502167 JF - 2007 Keystone Symposia on Host Cell Interaction and Response to the Cancer Cell (A8) AU - Restifo, Nicholas P Y1 - 2007/01/21/ PY - 2007 DA - 2007 Jan 21 KW - Immunotherapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39219974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Host+Cell+Interaction+and+Response+to+the+Cancer+Cell+%28A8%29&rft.atitle=Translating+the+Basic+Science+of+Tumor-Host+Interactions+into+New+Human+Immunotherapies&rft.au=Restifo%2C+Nicholas+P&rft.aulast=Restifo&rft.aufirst=Nicholas&rft.date=2007-01-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Host+Cell+Interaction+and+Response+to+the+Cancer+Cell+%28A8%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lipid Regulators of IgE/Fc Epsilon Homeostasis and Function T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39340932; 4502322 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Rivera, Juan Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Lipids KW - Homeostasis KW - Fc KW - Immunoglobulin E KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39340932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Lipid+Regulators+of+IgE%2FFc+Epsilon+Homeostasis+and+Function&rft.au=Rivera%2C+Juan&rft.aulast=Rivera&rft.aufirst=Juan&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Transmembrane Adaptor Protein (TRAP) NTAL/LAB/LAT2 (NTAL) in Mast Cell Activation T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39321304; 4502303 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Tkaczyk, Christine Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Mast cells KW - Acid phosphatase (tartrate-resistant) KW - Cell activation KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39321304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Role+of+the+Transmembrane+Adaptor+Protein+%28TRAP%29+NTAL%2FLAB%2FLAT2+%28NTAL%29+in+Mast+Cell+Activation&rft.au=Tkaczyk%2C+Christine&rft.aulast=Tkaczyk&rft.aufirst=Christine&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sphingosine Kinases are Determinants of Mast Cell Function and Anaphylaxis T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39313029; 4502327 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Olivera, Ana Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Anaphylaxis KW - Mast cells KW - Sphingosine kinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Sphingosine+Kinases+are+Determinants+of+Mast+Cell+Function+and+Anaphylaxis&rft.au=Olivera%2C+Ana&rft.aulast=Olivera&rft.aufirst=Ana&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preservation of Innate and Acquired Immune Function in Mast Cells Following Radiation Exposure T2 - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AN - 39312921; 4502310 JF - 2007 Keystone Symposia on Mast Cells, Basophils, and IgE: Host Defense and Disease (A6) AU - Brown, Jared M Y1 - 2007/01/20/ PY - 2007 DA - 2007 Jan 20 KW - Mast cells KW - Immune response KW - Radiation KW - Preservation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.atitle=Preservation+of+Innate+and+Acquired+Immune+Function+in+Mast+Cells+Following+Radiation+Exposure&rft.au=Brown%2C+Jared+M&rft.aulast=Brown&rft.aufirst=Jared&rft.date=2007-01-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Mast+Cells%2C+Basophils%2C+and+IgE%3A+Host+Defense+and+Disease+%28A6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 2&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Conformation of the HIV-1 Gag Protein in Solution AN - 19848254; 7246118 AB - A single multi-domain viral protein, termed Gag, is sufficient for assembly of retrovirus-like particles in mammalian cells. We have purified the human immunodeficiency virus type 1 (HIV-1) Gag protein (lacking myristate at its N terminus and the p6 domain at its C terminus) from bacteria. This protein is capable of assembly into virus-like particles in a defined in vitro system. We have reported that it is in monomer-dimer equilibrium in solution, and have described a mutant Gag protein that remains monomeric at high concentrations in solution. We report that the mutant protein retains several properties of wild-type Gag. This mutant enabled us to analyze solutions of monomeric protein. Hydrodynamic studies on the mutant protein showed that it is highly asymmetric, with a frictional ratio of 1.66. Small-angle neutron scattering (SANS) experiments confirmed its asymmetry and yielded an R sub(g) value of 34 A. Atomic-level structures of individual domains within Gag have previously been determined, but these domains are connected in Gag by flexible linkers. We constructed a series of models of the mutant Gag protein based on these domain structures, and tested each model computationally for its agreement with the experimental hydrodynamic and SANS data. The only models consistent with the data were those in which Gag was folded over, with its N-terminal matrix domain near its C-terminal nucleocapsid domain in three-dimensional space. Since Gag is a rod-shaped molecule in the assembled immature virion, these findings imply that Gag undergoes a major conformational change upon virus assembly. JF - Journal of Molecular Biology AU - Datta, SAK AU - Curtis, JE AU - Ratcliff, W AU - Clark, P K AU - Crist, R M AU - Lebowitz, J AU - Krueger, S AU - Rein, A AD - National Cancer Institute-Frederick, Frederick, MD 21702-1201, USA, rein@ncifcrf.gov Y1 - 2007/01/19/ PY - 2007 DA - 2007 Jan 19 SP - 812 EP - 824 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 365 IS - 3 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Virions KW - Virus-like particles KW - Data processing KW - Hydrodynamics KW - Mammalian cells KW - Neutron scattering KW - Human immunodeficiency virus 1 KW - Asymmetry KW - Nucleocapsids KW - Gag protein KW - J 02310:Genetics & Taxonomy KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Conformation+of+the+HIV-1+Gag+Protein+in+Solution&rft.au=Datta%2C+SAK%3BCurtis%2C+JE%3BRatcliff%2C+W%3BClark%2C+P+K%3BCrist%2C+R+M%3BLebowitz%2C+J%3BKrueger%2C+S%3BRein%2C+A&rft.aulast=Datta&rft.aufirst=SAK&rft.date=2007-01-19&rft.volume=365&rft.issue=3&rft.spage=812&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.10.073 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virions; Data processing; Virus-like particles; Mammalian cells; Hydrodynamics; Neutron scattering; Asymmetry; Nucleocapsids; Gag protein; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1016/j.jmb.2006.10.073 ER - TY - CPAPER T1 - Positional Stability of Single Double Strand Breaks in Living Mammalian Cells T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39313977; 4502113 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Soutoglou, Evi Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Mammalian cells KW - Stranding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39313977?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Positional+Stability+of+Single+Double+Strand+Breaks+in+Living+Mammalian+Cells&rft.au=Soutoglou%2C+Evi&rft.aulast=Soutoglou&rft.aufirst=Evi&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - p53 Biological Network: Inflammation, microRNA and Cancer T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39299464; 4502077 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Harris, Curtis C Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Cancer KW - MiRNA KW - P53 protein KW - Inflammation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39299464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=p53+Biological+Network%3A+Inflammation%2C+microRNA+and+Cancer&rft.au=Harris%2C+Curtis+C&rft.aulast=Harris&rft.aufirst=Curtis&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between DNA Damage Detection and Signaling In Vivo T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39250793; 4502130 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Nussenzweig, Andre Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Signal transduction KW - DNA damage KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39250793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Relationship+between+DNA+Damage+Detection+and+Signaling+In+Vivo&rft.au=Nussenzweig%2C+Andre&rft.aulast=Nussenzweig&rft.aufirst=Andre&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Premature Aging and DNA Repair T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39247649; 4502120 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Bohr, Vilhelm A Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Aging KW - DNA repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39247649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Human+Premature+Aging+and+DNA+Repair&rft.au=Bohr%2C+Vilhelm+A&rft.aulast=Bohr&rft.aufirst=Vilhelm&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Controlling the Outcome of Meiotic Double-Strand Break Repair T2 - 2007 Keystone Symposia on Genome Instability and Repair (A5) AN - 39241734; 4502083 JF - 2007 Keystone Symposia on Genome Instability and Repair (A5) AU - Lichten, Michael J Y1 - 2007/01/17/ PY - 2007 DA - 2007 Jan 17 KW - Meiosis KW - Double-strand break repair KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39241734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.atitle=Controlling+the+Outcome+of+Meiotic+Double-Strand+Break+Repair&rft.au=Lichten%2C+Michael+J&rft.aulast=Lichten&rft.aufirst=Michael&rft.date=2007-01-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Genome+Instability+and+Repair+%28A5%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=82 8&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Biochemical Analysis of LRRK2 Parkinsons Disease Associated Mutations T2 - 2007 Keystone Symposia on Molecular Mechanisms of Neurodegeneration (A4) AN - 39265447; 4502428 JF - 2007 Keystone Symposia on Molecular Mechanisms of Neurodegeneration (A4) AU - Lewis, Patrick A Y1 - 2007/01/16/ PY - 2007 DA - 2007 Jan 16 KW - Mutation KW - Biochemical analysis KW - Movement disorders KW - Neurodegenerative diseases KW - Parkinson's disease KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39265447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Molecular+Mechanisms+of+Neurodegeneration+%28A4%29&rft.atitle=Biochemical+Analysis+of+LRRK2+Parkinsons+Disease+Associated+Mutations&rft.au=Lewis%2C+Patrick+A&rft.aulast=Lewis&rft.aufirst=Patrick&rft.date=2007-01-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Molecular+Mechanisms+of+Neurodegeneration+%28A4%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=84 1&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Assessing the role of DRD5 and DYT1 in two different case-control series with primary blepharospasm. AN - 85399557; pmid-17133500 AB - Primary blepharospasm is a common adult-onset focal dystonia. Polymorphisms of the genes encoding TorsinA (DYT1) and the D5 dopamine receptor (DRD5) have previously been associated with lifetime risk for focal dystonia. We describe here experiments testing common variability within these two genes in two independent cohorts of Italian and North American patients with primary blepharospasm. We have failed to identify a consistent association with disease in the two patient groups examined here; however, analysis of the Italian group reveals an association with the same risk genotype in DYT1 as previously described in an Icelandic population. We have also found global significant DYT1 haplotype differences between patients and controls in the Italian series. These data suggest that further examination is warranted of the role genetic variability at this locus plays in the risk for primary dystonia.(c) 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Clarimon, Jordi AU - Brancati, Francesco AU - Peckham, Elizabeth AU - Valente, Enza Maria AU - Dallapiccola, Bruno AU - Abruzzese, Giovanni AU - Girlanda, Paolo AU - Defazio, Giovanni AU - Berardelli, Alfredo AU - Hallett, Mark AU - Singleton, Andrew B AD - Molecular Genetics Unit, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. jclarimon@santpau.es Y1 - 2007/01/15/ PY - 2007 DA - 2007 Jan 15 SP - 162 EP - 166 VL - 22 IS - 2 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Blepharospasm: diagnosis KW - *Blepharospasm: genetics KW - *Blepharospasm: physiopathology KW - Case-Control Studies KW - DNA Primers: genetics KW - Female KW - Gene Frequency KW - Genotype KW - Humans KW - Linkage Disequilibrium: genetics KW - Male KW - Microsatellite Repeats: genetics KW - Middle Aged KW - Molecular Chaperones: genetics KW - *Molecular Chaperones: physiology KW - Polymerase Chain Reaction KW - Polymorphism, Genetic: genetics KW - Receptors, Dopamine D5: genetics KW - *Receptors, Dopamine D5: physiology KW - Severity of Illness Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85399557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Assessing+the+role+of+DRD5+and+DYT1+in+two+different+case-control+series+with+primary+blepharospasm.&rft.au=Clarimon%2C+Jordi%3BBrancati%2C+Francesco%3BPeckham%2C+Elizabeth%3BValente%2C+Enza+Maria%3BDallapiccola%2C+Bruno%3BAbruzzese%2C+Giovanni%3BGirlanda%2C+Paolo%3BDefazio%2C+Giovanni%3BBerardelli%2C+Alfredo%3BHallett%2C+Mark%3BSingleton%2C+Andrew+B&rft.aulast=Clarimon&rft.aufirst=Jordi&rft.date=2007-01-15&rft.volume=22&rft.issue=2&rft.spage=162&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Helicobacter pylori and oesophageal and gastric cancers in a prospective study in China AN - 807271747; 13759737 AB - In a cohort of 29584 residents of Linxian, China, followed from 1985 to 2001, we conducted a case-cohort study of the magnitude of the association of Helicobacter pylori seropositivity with cancer risk in a random sample of 300 oesophageal squamous cell carcinomas, 600 gastric cardia adenocarcinomas, all 363 diagnosed gastric non-cardia adenocarcinomas, and a random sample of the entire cohort (N=1050). Baseline serum was evaluated for IgG antibodies to whole-cell and CagA H. pylori antigens by enzyme-linked immunosorbent assay. Risks of both gastric cardia and non-cardia cancers were increased in individuals exposed to H. pylori (Hazard ratios (HRs) and 95% confidence intervals=1.64; 1.26-2.14, and 1.60; 1.15-2.21, respectively), whereas risk of oesophageal squamous cell cancer was not affected (1.17; 0.88-1.57). For both cardia and non-cardia cancers, HRs were higher in younger individuals. With longer time between serum collection to cancer diagnosis, associations became stronger for cardia cancers but weaker for non-cardia cancers. CagA positivity did not modify these associations. The associations between H. pylori exposure and gastric cardia and non-cardia adenocarcinoma development were equally strong, in contrast to Western countries, perhaps due to the absence of Barrett's oesophagus and oesophageal adenocarcinomas in Linxian, making all cardia tumours of gastric origin, rather than a mixture of gastric and oesophageal malignancies.British Journal of Cancer (2007) 96, 172-176. doi doi:10.1038/sj.bjc.6603517 www.bjcancer.com Published online 19 December 2006 JF - British Journal of Cancer AU - Kamangar, F AU - Qiao, Y-L AU - Blaser, M J AU - Sun, X-D AU - Katki, H AU - Fan, J-H AU - Perez-Perez, G I AU - Abnet, C C AU - Zhao, P AU - Mark, S D AU - Taylor, P R AU - Dawsey, S M AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, Rm 3034, Bethesda, MD 20892-7232, USA Y1 - 2007/01/15/ PY - 2007 DA - 2007 Jan 15 SP - 172 EP - 176 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 96 IS - 1 SN - 0007-0920, 0007-0920 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - Risk assessment KW - Esophagus KW - Helicobacter pylori KW - Enzyme-linked immunosorbent assay KW - Medical research KW - tumors KW - squamous cell carcinoma KW - Tumors KW - Cancer KW - Immunoglobulin G KW - China, People's Rep. KW - Gastrointestinal tract KW - Adenocarcinoma KW - Gastric cancer KW - Immunoassays KW - Internet KW - R2 23060:Medical and environmental health KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807271747?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Helicobacter+pylori+and+oesophageal+and+gastric+cancers+in+a+prospective+study+in+China&rft.au=Kamangar%2C+F%3BQiao%2C+Y-L%3BBlaser%2C+M+J%3BSun%2C+X-D%3BKatki%2C+H%3BFan%2C+J-H%3BPerez-Perez%2C+G+I%3BAbnet%2C+C+C%3BZhao%2C+P%3BMark%2C+S+D%3BTaylor%2C+P+R%3BDawsey%2C+S+M&rft.aulast=Kamangar&rft.aufirst=F&rft.date=2007-01-15&rft.volume=96&rft.issue=1&rft.spage=172&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603517 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Esophagus; Enzyme-linked immunosorbent assay; Immunoglobulin G; squamous cell carcinoma; Tumors; Gastric cancer; Adenocarcinoma; Internet; Risk assessment; Medical research; tumors; Gastrointestinal tract; Immunoassays; Cancer; Helicobacter pylori; China, People's Rep. DO - http://dx.doi.org/10.1038/sj.bjc.6603517 ER - TY - CPAPER T1 - CODs (Clusters of Orthologous Domains) - New Resource for Comparative Genomics of Eukaryotes T2 - XV Conference on Plant and Animal Genome (PAG-XV) AN - 39342886; 4507544 JF - XV Conference on Plant and Animal Genome (PAG-XV) AU - Mekhedov, Sergei Y1 - 2007/01/13/ PY - 2007 DA - 2007 Jan 13 KW - Chemical oxygen demand KW - Genomics KW - Marine fish KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39342886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.atitle=CODs+%28Clusters+of+Orthologous+Domains%29+-+New+Resource+for+Comparative+Genomics+of+Eukaryotes&rft.au=Mekhedov%2C+Sergei&rft.aulast=Mekhedov&rft.aufirst=Sergei&rft.date=2007-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/15/15-workshops.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gnomon a Multi-Step Combined Gene Prediction Program T2 - XV Conference on Plant and Animal Genome (PAG-XV) AN - 39259102; 4507125 JF - XV Conference on Plant and Animal Genome (PAG-XV) AU - Souvorov, Alexander Y1 - 2007/01/13/ PY - 2007 DA - 2007 Jan 13 KW - Bioinformatics KW - Computer programs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39259102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.atitle=Gnomon+a+Multi-Step+Combined+Gene+Prediction+Program&rft.au=Souvorov%2C+Alexander&rft.aulast=Souvorov&rft.aufirst=Alexander&rft.date=2007-01-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XV+Conference+on+Plant+and+Animal+Genome+%28PAG-XV%29&rft.issn=&rft_id=info:doi/ L2 - http://www.intl-pag.org/15/15-workshops.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - SRF is a nuclear repressor of Smad3-mediated TGF-beta signaling. AN - 68418819; 16819512 AB - Serum response factor (SRF) is a widely expressed transcription factor involved in immediate-early and tissue-specific gene expression, cell proliferation and differentiation. We defined a new role of SRF as a nuclear repressor of the tumor growth factor beta1 (TGF-beta1) growth-inhibitory signal during cell proliferation. We show that SRF significantly inhibits the TGF-beta1/Smad-dependent transcription by associating with Smad3. SRF causes resistance to the TGF-beta1 cytostatic response by directly repressing the Smad transcriptional activity and Smad binding to DNA. Furthermore, we demonstrated that overexpression of SRF markedly decreases the level of Smad3 complex binding to the promoters of Smad3 target genes, p15(INK4b) and p21(Cip1). This leads to the inhibition of expression of TGF-beta1-responsive genes. SRF therefore acts as a nuclear repressor of Smad3-mediated TGF-beta1 signaling. JF - Oncogene AU - Lee, H-J AU - Yun, C-H AU - Lim, S H AU - Kim, B-C AU - Baik, K G AU - Kim, J-M AU - Kim, W-H AU - Kim, S-J AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. Y1 - 2007/01/11/ PY - 2007 DA - 2007 Jan 11 SP - 173 EP - 185 VL - 26 IS - 2 SN - 0950-9232, 0950-9232 KW - CDKN1A protein, human KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p15 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - Repressor Proteins KW - Serum Response Factor KW - Smad3 Protein KW - Transforming Growth Factor beta1 KW - Index Medicus KW - Liver Neoplasms -- metabolism KW - HeLa Cells KW - Humans KW - Lung -- cytology KW - Transcriptional Activation KW - Epithelial Cells -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Liver Neoplasms -- pathology KW - Cells, Cultured KW - Carcinoma, Hepatocellular -- pathology KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism KW - Kidney -- cytology KW - Promoter Regions, Genetic -- genetics KW - Gene Expression Regulation KW - Cyclin-Dependent Kinase Inhibitor p15 -- metabolism KW - Serum Response Factor -- genetics KW - Smad3 Protein -- metabolism KW - Repressor Proteins -- metabolism KW - Transforming Growth Factor beta1 -- pharmacology KW - Transcription, Genetic KW - Serum Response Factor -- metabolism KW - Repressor Proteins -- genetics KW - Signal Transduction KW - Smad3 Protein -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68418819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=SRF+is+a+nuclear+repressor+of+Smad3-mediated+TGF-beta+signaling.&rft.au=Lee%2C+H-J%3BYun%2C+C-H%3BLim%2C+S+H%3BKim%2C+B-C%3BBaik%2C+K+G%3BKim%2C+J-M%3BKim%2C+W-H%3BKim%2C+S-J&rft.aulast=Lee&rft.aufirst=H-J&rft.date=2007-01-11&rft.volume=26&rft.issue=2&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2007-01-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Elevated risk of lung cancer among people with AIDS AN - 21035617; 7296538 AB - Background and objectives: Lung cancer is a common malignancy among people with AIDS (PWA). Lung cancer risk was compared between PWA and the general population and its relationship with immunosuppression was assessed. The likelihood that excess risk is explained by a high prevalence of smoking was also investigated. Methods: Records on adolescent and adult PWA (N = 397927) were linked with cancer registries in 11 US regions. Cancer risk was assessed for the period 60 months before to 60 months after AIDS onset, with specific emphasis on the period 4-27 months after onset. Observed incidence was compared with general population rates and rates from a lung cancer prediction model for smokers. Results: Compared with the general population, lung cancer risk among PWA was elevated overall [n = 1489 cases; standardized incidence ratio (SIR), 3.8; 95% confidence interval (CI), 3.6-4.1 ] and in the 4-27 months after AIDS (n = 393 cases; SIR, 2.9; 95% CI, 2.6-3.2). In the 4-27 months after AIDS, risk was significantly elevated for all demographic subgroups, and was especially high among young PWA (SIRs for ages 15-29 years, 10.4; 30-39 years, 6.3; 40-49 years, 3.7). Lung cancers generally presented at an advanced stage. Risk was not associated with CD4 cell counts at AIDS (P sub(trend) = 0.36). Under plausible smoking assumptions, observed incidence was significantly higher than predicted among 40-49 and 50-59-year-old men with AIDS (observed/ predicted =5.03 and 1.43, respectively) and 40-49-year-old women with AIDS (observed/predicted = 1.88), but not among older PWA. Conclusion: Lung cancer risk was substantially elevated among PWA. Smoking could not entirely account for the observed elevation, especially among younger adults, suggesting a role for additional co-factors. JF - AIDS AU - Chaturvedi, A K AU - Pfeiffer, R M AU - Chang, L AU - Goedert, J J AU - Biggar, R J AU - Engels, E A AD - Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS 7072, Rockville, MD 20852, USA, chaturva@mail.nih.gov Y1 - 2007/01/11/ PY - 2007 DA - 2007 Jan 11 SP - 207 EP - 213 VL - 21 IS - 2 SN - 0269-9370, 0269-9370 KW - Immunology Abstracts; Risk Abstracts; Virology & AIDS Abstracts KW - demography KW - Acquired immune deficiency syndrome KW - Age KW - Adolescence KW - Demography KW - Smoking KW - Malignancy KW - CD4 antigen KW - prediction models KW - Adolescents KW - Lung cancer KW - Immunosuppression KW - V 22360:AIDS and HIV KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS&rft.atitle=Elevated+risk+of+lung+cancer+among+people+with+AIDS&rft.au=Chaturvedi%2C+A+K%3BPfeiffer%2C+R+M%3BChang%2C+L%3BGoedert%2C+J+J%3BBiggar%2C+R+J%3BEngels%2C+E+A&rft.aulast=Chaturvedi&rft.aufirst=A&rft.date=2007-01-11&rft.volume=21&rft.issue=2&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=AIDS&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Demography; Smoking; Age; CD4 antigen; Malignancy; Acquired immune deficiency syndrome; Adolescence; Immunosuppression; Lung cancer; demography; prediction models; Adolescents ER - TY - JOUR T1 - Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector AN - 19850283; 7273486 AB - NgR1, NgR2, and NgR3 which constitute the Nogo-66 receptor family are primarily expressed by neurons in the central nervous system (CNS) and believed to limit axonal growth and sprouting following CNS injury. In an attempt to define the expression and decipher the function of individual members of the Nogo-66 receptor family, we previously reported the generation of selective rabbit polyclonal antibodies. Here we exploit the same immune repertoires by phage display technology to generate rabbit monoclonal antibodies (mAbs) with nanomolar affinity to epitopes that are specific for NgR1 and NgR2, respectively, but at the same time conserved between mouse, rat, and human orthologs. Employing phage display vector pC3C, a newly designed phagemid optimized for the generation and selection of Fab libraries with human constant domains, rabbit mAbs were selected from chimeric rabbit/human Fab libraries, characterized in terms of specificity, affinity, and amino acid sequence, and finally converted to chimeric rabbit/human IgG. Using immunofluorescence microscopy and immunoprecipitation, we demonstrate strong and specific recognition of cell surface bound Nogo-66 receptor family members by chimeric rabbit/human IgG. The rabbit mAbs reported here together with their amino acid sequences constitute a defined panel of species cross-reactive reagents in infinite supply which will aid investigations toward a functional role of the Nogo-66 receptor family in and beyond the CNS. JF - Journal of Immunological Methods AU - Hofer, T AU - Tangkeangsirisin, W AU - Kennedy, M G AU - Mage, R G AU - Raiker, S J AU - Venkatesh, K AU - Lee, H AU - Giger, R J AU - Rader, C AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892-1203, USA, raderc@mail.nih.gov Y1 - 2007/01/10/ PY - 2007 DA - 2007 Jan 10 SP - 75 EP - 87 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 318 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Central nervous system KW - Cell surface KW - Cross-reactivity KW - Axon sprouting KW - Injuries KW - Nogo protein KW - Receptor mechanisms KW - Monoclonal antibodies KW - Phage display KW - Immunoprecipitation KW - Immunofluorescence KW - Antibodies KW - Neurons KW - Microscopy KW - Immunoglobulin G KW - Axonogenesis KW - Fab KW - Epitopes KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Chimeric+rabbit%2Fhuman+Fab+and+IgG+specific+for+members+of+the+Nogo-66+receptor+family+selected+for+species+cross-reactivity+with+an+improved+phage+display+vector&rft.au=Hofer%2C+T%3BTangkeangsirisin%2C+W%3BKennedy%2C+M+G%3BMage%2C+R+G%3BRaiker%2C+S+J%3BVenkatesh%2C+K%3BLee%2C+H%3BGiger%2C+R+J%3BRader%2C+C&rft.aulast=Hofer&rft.aufirst=T&rft.date=2007-01-10&rft.volume=318&rft.issue=1-2&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.10.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Central nervous system; Axon sprouting; Cross-reactivity; Receptor mechanisms; Nogo protein; Injuries; Monoclonal antibodies; Phage display; Immunoprecipitation; Immunofluorescence; Antibodies; Neurons; Microscopy; Immunoglobulin G; Axonogenesis; Fab; Epitopes; Amino acid sequence DO - http://dx.doi.org/10.1016/j.jim.2006.10.007 ER - TY - JOUR T1 - Proliferation and apoptosis in PhIP-induced rat mammary gland carcinomas with elevated phosphotyrosine-STAT5a. AN - 68375782; 17173897 AB - In the present study we addressed whether proliferation and apoptosis in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland carcinomas were different between carcinomas with high and low expression of phosphotyrosine (pY)-STAT5a. We determined that carcinomas with high pY-STAT5a were more proliferative (MIB5 immunostaining) and had a higher expression of cyclin D1 and estrogen receptor alpha. Furthermore, carcinomas with elevated pY-STAT5a demonstrated lower apoptosis as measured by the TUNEL assay and the Bcl-2 to Bax ratio, and showed increased expression of the long and short isoforms of the prolactin receptor. The results of this study are consistent with the notion that activated STAT5a may provide a growth advantage in some types of mammary gland cancers. JF - FEBS letters AU - Papaconstantinou, Andriana D AU - Snyderwine, Elizabeth G AD - Chemical Carcinogenesis Section, Laboratory of Experimental Carcinogenesis, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Y1 - 2007/01/09/ PY - 2007 DA - 2007 Jan 09 SP - 29 EP - 33 VL - 581 IS - 1 SN - 0014-5793, 0014-5793 KW - Bax protein, rat KW - 0 KW - Carcinogens KW - Cyclin D KW - Cyclins KW - Estrogen Receptor alpha KW - Imidazoles KW - STAT5 Transcription Factor KW - Stat5a protein, rat KW - bcl-2-Associated X Protein KW - Phosphotyrosine KW - 21820-51-9 KW - 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine KW - 909C6UN66T KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Tumor Cells, Cultured KW - Mammary Glands, Animal -- metabolism KW - Mammary Glands, Animal -- pathology KW - Cyclins -- metabolism KW - Estrogen Receptor alpha -- metabolism KW - Female KW - bcl-2-Associated X Protein -- metabolism KW - STAT5 Transcription Factor -- metabolism KW - Mammary Neoplasms, Experimental -- chemically induced KW - Imidazoles -- toxicity KW - Apoptosis KW - Phosphotyrosine -- metabolism KW - Carcinogens -- toxicity KW - Mammary Neoplasms, Experimental -- metabolism KW - Cell Proliferation KW - Mammary Neoplasms, Experimental -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68375782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Proliferation+and+apoptosis+in+PhIP-induced+rat+mammary+gland+carcinomas+with+elevated+phosphotyrosine-STAT5a.&rft.au=Papaconstantinou%2C+Andriana+D%3BSnyderwine%2C+Elizabeth+G&rft.aulast=Papaconstantinou&rft.aufirst=Andriana&rft.date=2007-01-09&rft.volume=581&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2006-12-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Prime-Boost Vaccination Against HIV Infection T2 - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AN - 39333219; 4502272 JF - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AU - Koup, Richard A Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - Human immunodeficiency virus KW - Infection KW - Vaccination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39333219?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.atitle=Prime-Boost+Vaccination+Against+HIV+Infection&rft.au=Koup%2C+Richard+A&rft.aulast=Koup&rft.aufirst=Richard&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TLR Ligands Influence the Quality of T Cell Responses T2 - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AN - 39312707; 4502251 JF - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AU - Seder, Robert A Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - Lymphocytes T KW - Ligands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39312707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.atitle=TLR+Ligands+Influence+the+Quality+of+T+Cell+Responses&rft.au=Seder%2C+Robert+A&rft.aulast=Seder&rft.aufirst=Robert&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Visceral Leishmaniasis is Associated with IL-10 Producing T Cells that are Distinct from CD4+CD25+ (Foxp3) Regulatory T Cells T2 - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AN - 39306975; 4502276 JF - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AU - Nylen-Spoomaker, Susanne I S Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - Lymphocytes T KW - Interleukin 10 KW - Immunoregulation KW - Foxp3 protein KW - CD25 antigen KW - CD4 antigen KW - Visceral leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.atitle=Human+Visceral+Leishmaniasis+is+Associated+with+IL-10+Producing+T+Cells+that+are+Distinct+from+CD4%2BCD25%2B+%28Foxp3%29+Regulatory+T+Cells&rft.au=Nylen-Spoomaker%2C+Susanne+I+S&rft.aulast=Nylen-Spoomaker&rft.aufirst=Susanne+I&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Signatures of the Immune Response to Guide the Diagnosis, Prognosis and Treatment of Cancer T2 - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AN - 39303383; 4502263 JF - 2007 Keystone Symposia on Immunological Intervention in Human Disease (A2) AU - Staudt, Louis M Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - Cancer KW - Immune response KW - Gene expression KW - Prognosis KW - Immunity KW - Defense mechanisms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39303383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.atitle=Gene+Expression+Signatures+of+the+Immune+Response+to+Guide+the+Diagnosis%2C+Prognosis+and+Treatment+of+Cancer&rft.au=Staudt%2C+Louis+M&rft.aulast=Staudt&rft.aufirst=Louis&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2007+Keystone+Symposia+on+Immunological+Intervention+in+Human+Disease+%28A2%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=85 5&AllowFutureView=1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection and Visualization of Low-Population Encounter Complexes in Protein-Protein and Protein-DNA Association by Paramagnetic Relaxation Enhancement T2 - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AN - 39255213; 4506215 JF - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AU - Clore, G Marius Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - Nucleic acids KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39255213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.atitle=Detection+and+Visualization+of+Low-Population+Encounter+Complexes+in+Protein-Protein+and+Protein-DNA+Association+by+Paramagnetic+Relaxation+Enhancement&rft.au=Clore%2C+G+Marius&rft.aulast=Clore&rft.aufirst=G&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMR Assignment of Polymerasebeta Labeled with 2H, 13C, and 15N in Complex with Substrate DNA T2 - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AN - 39249059; 4506195 JF - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AU - Mueller, Geoffrey A Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - N.M.R. KW - Nitrogen isotopes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39249059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.atitle=NMR+Assignment+of+Polymerasebeta+Labeled+with+2H%2C+13C%2C+and+15N+in+Complex+with+Substrate+DNA&rft.au=Mueller%2C+Geoffrey+A&rft.aulast=Mueller&rft.aufirst=Geoffrey&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weak Alignment Offers New Opportunities in NMR of Biomolecules T2 - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AN - 39248963; 4506186 JF - X Keystone Symposia on Frontiers of NMR in Molecular Biology (A3) AU - Bax, Ad Y1 - 2007/01/06/ PY - 2007 DA - 2007 Jan 06 KW - N.M.R. KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39248963?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.atitle=Weak+Alignment+Offers+New+Opportunities+in+NMR+of+Biomolecules&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2007-01-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=X+Keystone+Symposia+on+Frontiers+of+NMR+in+Molecular+Biology+%28A3%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/ViewMeetings.cfm?MeetingID=86 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Dual dopamine/serotonin releasers as potential medications for stimulant and alcohol addictions. AN - 70347813; 17408232 AB - We have advocated the idea of agonist therapy for treating cocaine addiction. This strategy involves administration of stimulant-like medications (eg, monoamine releasers) to alleviate withdrawal symptoms and prevent relapse. A major limitation of this approach is that many candidate medicines possess significant abuse potential because of activation of mesolimbic dopamine (DA) neurons in central nervous system reward circuits. Previous data suggest that serotonin (5-HT) neurons can provide an inhibitory influence over mesolimbic DA neurons. Thus, it might be predicted that the balance between DA and 5-HT transmission is important to consider when developing medications with reduced stimulant side effects. In this article, we discuss several issues related to the development of dual DA/5-HT releasers for the treatment of substance use disorders. First, we discuss evidence supporting the existence of a dual deficit in DA and 5-HT function during withdrawal from chronic cocaine or alcohol abuse. Then we summarize studies that have tested the hypothesis that 5-HT neurons can dampen the effects mediated by mesolimbic DA. For example, it has been shown that pharmacological manipulations that increase extracellular 5-HT attenuate stimulant effects produced by DA release, such as locomotor stimulation and self-administration behavior. Finally, we discuss our recently published data about PAL-287 (naphthylisopropylamine), a novel non-amphetamine DA-/5-HT-releasing agent that suppresses cocaine self-administration but lacks positive reinforcing properties. It is concluded that DA/5-HT releasers might be useful therapeutic adjuncts for the treatment of cocaine and alcohol addiction, obesity, and even attention deficit disorder and depression. JF - The AAPS journal AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. rrothman@mail.nih.gov Y1 - 2007/01/05/ PY - 2007 DA - 2007 Jan 05 SP - E1 EP - 10 VL - 9 IS - 1 KW - Dopamine Agents KW - 0 KW - Serotonin Agents KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Molecular Structure KW - Animals KW - Substance Withdrawal Syndrome -- metabolism KW - Substance Withdrawal Syndrome -- prevention & control KW - Humans KW - Structure-Activity Relationship KW - Serotonin Agents -- chemistry KW - Dopamine Agents -- therapeutic use KW - Dopamine -- deficiency KW - Serotonin Agents -- pharmacology KW - Dopamine Agents -- pharmacology KW - Cocaine-Related Disorders -- drug therapy KW - Dopamine -- metabolism KW - Alcoholism -- metabolism KW - Serotonin Agents -- therapeutic use KW - Serotonin -- metabolism KW - Dopamine Agents -- chemistry KW - Cocaine-Related Disorders -- metabolism KW - Alcoholism -- drug therapy KW - Serotonin -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70347813?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+AAPS+journal&rft.atitle=Dual+dopamine%2Fserotonin+releasers+as+potential+medications+for+stimulant+and+alcohol+addictions.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2007-01-05&rft.volume=9&rft.issue=1&rft.spage=E1&rft.isbn=&rft.btitle=&rft.title=The+AAPS+journal&rft.issn=1550-7416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-03 N1 - Date created - 2007-04-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Prog Neurobiol. 2005 Apr;75(6):406-33 [15955613] Physiology (Bethesda). 2005 Aug;20:225-31 [16024510] Am J Psychiatry. 2005 Aug;162(8):1414-22 [16055762] Eur J Pharmacol. 2005 Dec 5;526(1-3):113-24 [16288736] Synapse. 2006 Apr;59(5):277-89 [16416445] Neural Netw. 2002 Jun-Jul;15(4-6):603-16 [12371515] Alcohol Clin Exp Res. 2003 Feb;27(2):232-43 [12605072] Front Neuroendocrinol. 1994 Jun;15(2):85-156 [7813744] J Exp Biol. 1994 Nov;196:229-36 [7823024] J Exp Biol. 1994 Nov;196:263-81 [7823027] N Engl J Med. 1995 Nov 2;333(18):1196-203 [7565976] J Pharmacol Exp Ther. 1995 Sep;274(3):1182-91 [7562486] MMWR Morb Mortal Wkly Rep. 1995 Dec 1;44(47):882-6 [7476843] J Pharmacol Exp Ther. 1995 Dec;275(3):1551-9 [8531128] J Neurosci. 1996 May 15;16(10):3474-85 [8627380] Clin Neuropharmacol. 1995 Apr;18(2):183-95 [8635177] Curr Probl Cardiol. 1999 Dec;24(12):745-92 [10609092] Mol Pharmacol. 2000 Jan;57(1):75-81 [10617681] Synapse. 2000 May;36(2):102-13 [10767057] J Subst Abuse Treat. 2000 Jul;19(1):77-9 [10867304] Psychopharmacology (Berl). 2000 Jul;150(4):361-73 [10958077] Synapse. 2001 Jan;39(1):32-41 [11071707] Circulation. 2000 Dec 5;102(23):2836-41 [11104741] Psychol Addict Behav. 2000 Dec;14(4):390-6 [11130157] Neuropsychopharmacology. 2001 May;24(5):492-501 [11282249] Am J Med Sci. 2001 Apr;321(4):292-9 [11307870] J Clin Psychopharmacol. 2001 Oct;21(5):522-6 [11593078] Pharmacol Biochem Behav. 2002 Jan-Feb;71(1-2):197-204 [11812523] J Pharmacol Exp Ther. 2002 Mar;300(3):831-7 [11861788] Pharmacol Biochem Behav. 2002 Apr;71(4):825-36 [11888573] Ann N Y Acad Sci. 2002 Jun;965:109-26 [12105089] Pharmacol Ther. 2002 Jul;95(1):73-88 [12163129] Nat Med. 2002 Oct;8(10):1129-35 [12244304] Alcohol. 1997 Jan-Feb;14(1):45-8 [9014023] Mol Psychiatry. 1996 Jul;1(3):232-54 [9118348] Neuroreport. 1997 Apr 14;8(6):1347-51 [9172133] Adv Pharmacol. 1998;42:995-7 [9328065] J Clin Psychopharmacol. 1997 Dec;17(6):485-8 [9408812] Am J Addict. 1998 Spring;7(2):142-55 [9598218] Ann N Y Acad Sci. 1998 May 30;844:59-74 [9668665] Synapse. 1998 Sep;30(1):107-11 [9704887] Drug Alcohol Depend. 1998 Jun-Jul;51(1-2):87-96 [9716932] Biol Psychiatry. 1998 Oct 1;44(7):578-91 [9787882] J Pharmacol Exp Ther. 1999 Feb;288(2):550-60 [9918558] Psychopharmacology (Berl). 1999 Apr;143(3):309-14 [10353435] Alcohol. 1999 May;18(1):55-64 [10386666] Psychopharmacology (Berl). 1999 Jun;144(4):389-97 [10435412] Pharmacol Rev. 1999 Sep;51(3):439-64 [10471414] Psychopharmacology (Berl). 1999 Aug;145(3):283-94 [10494577] Drug Alcohol Depend. 2003 May 1;70(1):39-52 [12681524] Drug Alcohol Depend. 2003 May 1;70(1):101-4 [12681530] Psychopharmacology (Berl). 2003 May;167(3):324-32 [12652348] Mol Pharmacol. 2003 Jun;63(6):1223-9 [12761331] Psychopharmacology (Berl). 2003 Jul;168(1-2):146-54 [12529808] Nat Rev Neurosci. 2003 Oct;4(10):819-28 [14523381] Eur J Pharmacol. 2003 Oct 31;479(1-3):23-40 [14612135] Eur J Pharmacol. 2003 Oct 31;479(1-3):229-36 [14612153] Eur J Pharmacol. 2003 Nov 7;480(1-3):151-62 [14623358] Neuropsychopharmacology. 2004 Apr;29(4):660-8 [14627998] Neuropsychopharmacology. 2004 May;29(5):969-81 [15039761] Addict Behav. 2004 Sep;29(7):1439-64 [15345275] Cor Vasa. 1985;27(2-3):160-71 [3928246] Neurosci Biobehav Rev. 1985 Fall;9(3):469-77 [2999657] Arch Gen Psychiatry. 1986 Feb;43(2):107-13 [3947206] Pharmacol Biochem Behav. 1986 Oct;25(4):849-55 [2431419] J Med Chem. 1990 Feb;33(2):703-10 [1967651] Pharmacol Biochem Behav. 1990 Jan;35(1):237-44 [2315363] Neuropsychopharmacology. 1991 Jan;4(1):17-26 [2003866] Ciba Found Symp. 1992;166:7-14; discussion 14-9 [1638922] Pharmacol Biochem Behav. 1993 Mar;44(3):651-5 [8451268] Annu Rev Neurosci. 1993;16:73-93 [8096377] Md Med J. 1993 Feb;42(2):153-6 [8097012] J Clin Pharmacol. 1993 Apr;33(4):296-310 [8473543] Biochim Biophys Acta. 1993 Oct 4;1144(3):249-63 [8104483] J Subst Abuse Treat. 1994 May-Jun;11(3):273-5 [8072057] J Psychoactive Drugs. 1994 Apr-Jun;26(2):119-28 [7931856] Nat Rev Neurosci. 2004 Dec;5(12):963-70 [15550951] Synapse. 2005 May;56(2):94-9 [15729739] J Pharmacol Exp Ther. 2005 May;313(2):848-54 [15677348] J Pharmacol Exp Ther. 2005 Jun;313(3):1361-9 [15761112] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drugs and valvular heart disease. AN - 68392191; 17202450 JF - The New England journal of medicine AU - Roth, Bryan L AD - Department of Pharmacology, Schools of Medicine and Pharmacy, National Institute of Mental Health Psychoactive Drug Screening Program at the University of North Carolina, Chapel Hill, USA. Y1 - 2007/01/04/ PY - 2007 DA - 2007 Jan 04 SP - 6 EP - 9 VL - 356 IS - 1 KW - Antiparkinson Agents KW - 0 KW - Dopamine Agonists KW - Ergolines KW - Receptor, Serotonin, 5-HT2B KW - Serotonin 5-HT2 Receptor Agonists KW - Serotonin Receptor Agonists KW - Pergolide KW - 24MJ822NZ9 KW - cabergoline KW - LL60K9J05T KW - Abridged Index Medicus KW - Index Medicus KW - Serotonin Receptor Agonists -- pharmacology KW - Antiparkinson Agents -- adverse effects KW - Serotonin Receptor Agonists -- adverse effects KW - Receptor, Serotonin, 5-HT2B -- metabolism KW - Humans KW - Pergolide -- adverse effects KW - Dopamine Agonists -- adverse effects KW - Heart Valve Diseases -- chemically induced KW - Ergolines -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68392191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Drugs+and+valvular+heart+disease.&rft.au=Roth%2C+Bryan+L&rft.aulast=Roth&rft.aufirst=Bryan&rft.date=2007-01-04&rft.volume=356&rft.issue=1&rft.spage=6&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2007-01-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2007 Apr 19;356(16):1677-8; author reply 1678-80 [17447276] N Engl J Med. 2007 Apr 19;356(16):1677; author reply 1678-80 [17447278] N Engl J Med. 2007 Apr 19;356(16):1677; author reply 1678-80 [17447277] Comment On: N Engl J Med. 2007 Jan 4;356(1):39-46 [17202454] N Engl J Med. 2007 Jan 4;356(1):29-38 [17202453] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Report of the Working Group on Integrated Translational Research in DNA Repair AN - 20287677; 7272808 AB - On September 28-29, 2006, the National Institute of Environmental Health Sciences led a team from the National Institutes of Health in hosting a Working Group on Integrated Translational Research in DNA Repair, in Berkeley, CA. In recognition of the far-reaching goals for this area of investigation, the Working Group was charged with conceiving a vision to facilitate projects that would apply the lessons of DNA Repair research to clinical application and public health. The participants included basic and physician scientists working in the various areas of DNA Repair and genome stability, as well as agency representatives of the National Cancer Institute and the National Institute of General Medical Sciences. In constructing this vision of practical research recommendations, the Working Group was asked to identify roadblocks to progress, suggest enabling technologies, and to consider areas that are ripe for translation. This report summarizes the rationale for this initiative and the recommendations that emerged. JF - DNA Repair AU - Reinlib, L AU - Friedberg, E C AD - National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC, USA, Reinlib@niehs.nih.gov Y1 - 2007/01/04/ PY - 2007 DA - 2007 Jan 04 SP - 145 EP - 147 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 6 IS - 1 SN - 1568-7864, 1568-7864 KW - Health & Safety Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Translation KW - Vision KW - DNA KW - Environmental health KW - DNA repair KW - Cancer KW - Technology KW - Public health KW - N 14820:DNA Metabolism & Structure KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20287677?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Report+of+the+Working+Group+on+Integrated+Translational+Research+in+DNA+Repair&rft.au=Reinlib%2C+L%3BFriedberg%2C+E+C&rft.aulast=Reinlib&rft.aufirst=L&rft.date=2007-01-04&rft.volume=6&rft.issue=1&rft.spage=145&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2006.11.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Translation; Vision; DNA repair; Cancer; Public health; DNA; Environmental health; Technology DO - http://dx.doi.org/10.1016/j.dnarep.2006.11.006 ER - TY - JOUR T1 - Human MutL alpha : The jack of all trades in MMR is also an endonuclease AN - 19777499; 7272806 AB - Recently, Paul Modrich's group reported the discovery of an intrinsic endonuclease activity for human MutL alpha . This breakthrough provides a satisfactory answer to the longstanding puzzle of a missing nuclease activity in human mismatch repair and will undoubtedly lead to new investigations of DNA repair and replication. Here, the implications of this exciting new finding are discussed in the context of mismatch repair in Escherichia coli and humans. JF - DNA Repair AU - Yang, W AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA, Wei.Yang@nih.gov Y1 - 2007/01/04/ PY - 2007 DA - 2007 Jan 04 SP - 135 EP - 139 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 6 IS - 1 SN - 1568-7864, 1568-7864 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - mismatch repair KW - Replication KW - Escherichia coli KW - Nuclease KW - Endonuclease KW - DNA repair KW - N 14820:DNA Metabolism & Structure KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19777499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+Repair&rft.atitle=Human+MutL+alpha+%3A+The+jack+of+all+trades+in+MMR+is+also+an+endonuclease&rft.au=Yang%2C+W&rft.aulast=Yang&rft.aufirst=W&rft.date=2007-01-04&rft.volume=6&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=DNA+Repair&rft.issn=15687864&rft_id=info:doi/10.1016%2Fj.dnarep.2006.10.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - mismatch repair; Replication; Nuclease; DNA repair; Endonuclease; Escherichia coli DO - http://dx.doi.org/10.1016/j.dnarep.2006.10.021 ER - TY - JOUR T1 - Risk of Soft Tissue Sarcomas by Individual Subtype in Survivors of Hereditary Retinoblastoma AN - 20722761; 7253565 AB - BACKGROUND: Survivors of hereditary retinoblastoma have an increased risk for second malignancies, especially soft tissue sarcomas. However, the risks of individual histologic subtypes of soft tissue sarcomas have not been evaluated. METHODS: We estimated the risk for six subtypes of soft tissue sarcomas (fibrosarcoma, liposarcoma, histiocytoma, leiomyosarcoma, rhabdomyosarcoma, and others) in a cohort of 963 one-year survivors of hereditary retinoblastoma among patients diagnosed at two US institutions from 1914 through 1984. We calculated standardized incidence ratios (SIRs) for specific subtypes of soft tissue sarcomas by comparison with population data from the Connecticut Tumor Registry or from National Cancer Institute Surveillance, Epidemiology, and End Results database. We also calculated the cumulative risk for all soft tissue sarcomas combined. RESULTS: We observed 69 soft tissue sarcomas in 68 patients with hereditary retinoblastoma. Risks were elevated for soft tissue sarcomas overall (SIR = 184, 95% confidence interval [CI] = 143 to 233) and for individual subtypes. Leiomyosarcoma was the most frequent subtype (SIR = 390, 95% CI = 247 to 585), with 78% of leiomyosarcomas diagnosed 30 or more years after the retinoblastoma diagnosis (SIR = 435, 95% CI = 258 to 687). Among patients treated with radiotherapy for retinoblastoma, we found statistically significantly increased risks of soft tissue sarcomas in the field of radiation. Irradiated patients also had increased risks of soft tissue sarcomas, especially leiomyosarcomas, outside the field of radiation, and risks of soft tissue sarcomas were increased in nonirradiated patients as well, indicating a genetic predisposition to soft tissue sarcomas independent of radiation. The cumulative risk for any soft tissue sarcoma 50 years after radiotherapy for retinoblastoma was 13.1% (95% CI = 9.7% to 17.0%). CONCLUSION: Long-term follow-up of a cohort of survivors of hereditary retinoblastoma revealed a statistically significant excess of leiomyosarcoma and other soft tissue sarcomas that persists decades after the retinoblastoma diagnosis. Retinoblastoma survivors should undergo regular medical surveillance for sarcomas in their adult years. JF - Journal of the National Cancer Institute AU - Kleinerman, Ruth A AU - Tucker, Margaret A AU - Abramson, David H AU - Seddon, Johanna M AU - Tarone, Robert E AU - Fraumeni, Joseph FJr AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (RAK, MAT, JFF) Y1 - 2007/01/03/ PY - 2007 DA - 2007 Jan 03 SP - 24 EP - 31 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 1 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Tissues KW - USA, Connecticut KW - ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir KW - Standards KW - tumors KW - radiotherapy KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Risk+of+Soft+Tissue+Sarcomas+by+Individual+Subtype+in+Survivors+of+Hereditary+Retinoblastoma&rft.au=Kleinerman%2C+Ruth+A%3BTucker%2C+Margaret+A%3BAbramson%2C+David+H%3BSeddon%2C+Johanna+M%3BTarone%2C+Robert+E%3BFraumeni%2C+Joseph+FJr&rft.aulast=Kleinerman&rft.aufirst=Ruth&rft.date=2007-01-03&rft.volume=99&rft.issue=1&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tissues; tumors; Standards; radiotherapy; Cancer; USA, Connecticut; ISE, Pacific, New Zealand Island Terr., Niue I., Alofi, Sir ER - TY - JOUR T1 - A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease. AN - 68390093; 17200487 AB - To determine if future studies of coenzyme Q(10) and GPI-1485 in Parkinson disease (PD) may be warranted. We conducted a randomized, double-blind, calibrated futility clinical trial of coenzyme Q10 and GPI-1485 in early untreated PD using placebo data from the DATATOP study to establish the futility threshold. The primary outcome measure (change in total Unified Parkinson's Disease Rating Scale scores over 1 year) did not meet the prespecified criteria for futility for either agent. Secondary analyses using calibration controls and other more recent placebo data question the appropriateness of the predetermined definition of futility, and suggest that a more restrictive threshold may be needed. Coenzyme Q(10) and GPI-1485 may warrant further study in Parkinson disease, although the data are inconsistent. Additional factors (cost, availability of other agents, more recent data on placebo outcomes, other ongoing trials) should also be considered in the selection of agents for Phase III studies. JF - Neurology AU - NINDS NET-PD Investigators AD - NINDS NET-PD Investigators Y1 - 2007/01/02/ PY - 2007 DA - 2007 Jan 02 SP - 20 EP - 28 VL - 68 IS - 1 KW - Coenzymes KW - 0 KW - GPI 1485 KW - Ubiquinone KW - 1339-63-5 KW - coenzyme Q10 KW - EJ27X76M46 KW - Tacrolimus KW - WM0HAQ4WNM KW - Abridged Index Medicus KW - Index Medicus KW - Nausea -- chemically induced KW - Headache -- chemically induced KW - Double-Blind Method KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Female KW - Tacrolimus -- adverse effects KW - Tacrolimus -- therapeutic use KW - Ubiquinone -- therapeutic use KW - Tacrolimus -- analogs & derivatives KW - Ubiquinone -- adverse effects KW - Parkinson Disease -- physiopathology KW - Parkinson Disease -- enzymology KW - Ubiquinone -- analogs & derivatives KW - Parkinson Disease -- drug therapy KW - Parkinson Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68390093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=A+randomized+clinical+trial+of+coenzyme+Q10+and+GPI-1485+in+early+Parkinson+disease.&rft.au=NINDS+NET-PD+Investigators&rft.aulast=NINDS+NET-PD+Investigators&rft.aufirst=&rft.date=2007-01-02&rft.volume=68&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2007-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Long-lasting and transmission-blocking activity of antibodies to Plasmodium falciparum elicited in mice by protein conjugates of Pfs25 AN - 19843979; 7254905 AB - Malaria is a leading cause of morbidity and mortality, estimated to cause >1 million childhood deaths annually. Plasmodium falciparum causes the most severe form of the disease. There is as yet no licensed vaccine for this disease, despite over a half century of research. In this study, we investigated a transmission-blocking vaccine candidate, the ookinete surface protein Pfs25. Antibodies against Pfs25, drawn in during a bite, can block parasite development in the mosquito midgut, preventing transmission to other individuals. Pfs25 is a low-molecular-weight protein, by itself not immunogenic. To increase its immunogenicity, we investigated several methods of conjugating Pfs25 to itself and to other proteins: recombinant Pseudomonas aeruginosa exotoxin A, and ovalbumin, using amide, hydrazone, or thioether linkages. All conjugates were immunogenic and induced booster responses in mice. The scheme to form amide bonds between proteins by using adipic acid dihydrizide as a linker produced the most immunogenic conjugates. Adsorption of the conjugates onto aluminum hydroxide further increased the antibody response. Remarkably, the antibody levels 3 or 7 months after the last injection were significantly higher than those 1 wk after that injection. The observed transmission-blocking activity of immune sera correlated with antibody levels measured by ELISA. JF - Proceedings of the National Academy of Sciences, USA AU - Kubler-Kielb, Joanna AU - Majadly, Fathy AU - Wu, Yimin AU - Narum, David L AU - Guo, Chunyan AU - Miller, Louis H AU - Shiloach, Joseph AU - Robbins, John B AU - Schneerson, Rachel AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, 31 Center Drive, MSC 2423, Bethesda, MD 20892-2520 Y1 - 2007/01/02/ PY - 2007 DA - 2007 Jan 02 SP - 293 EP - 298 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 1 SN - 0027-8424, 0027-8424 KW - Pfs25 protein KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Ovalbumin KW - Mortality KW - Enzyme-linked immunosorbent assay KW - Zygotes KW - Bites KW - Aluminum hydroxide KW - Malaria KW - Plasmodium falciparum KW - Antibody response KW - Development KW - Children KW - exotoxin A KW - thioethers KW - Morbidity KW - Disease transmission KW - Immunogenicity KW - adipic acid KW - Adsorption KW - Midgut KW - Vaccines KW - Pseudomonas aeruginosa KW - amides KW - K 03350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Long-lasting+and+transmission-blocking+activity+of+antibodies+to+Plasmodium+falciparum+elicited+in+mice+by+protein+conjugates+of+Pfs25&rft.au=Kubler-Kielb%2C+Joanna%3BMajadly%2C+Fathy%3BWu%2C+Yimin%3BNarum%2C+David+L%3BGuo%2C+Chunyan%3BMiller%2C+Louis+H%3BShiloach%2C+Joseph%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2007-01-02&rft.volume=104&rft.issue=1&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mortality; Ovalbumin; Parasites; Enzyme-linked immunosorbent assay; Bites; Zygotes; Aluminum hydroxide; Malaria; Development; Antibody response; Children; exotoxin A; Morbidity; thioethers; Disease transmission; Immunogenicity; adipic acid; Adsorption; Vaccines; Midgut; amides; Plasmodium falciparum; Pseudomonas aeruginosa ER - TY - JOUR T1 - Effects of surface electrical stimulation both at rest and during swallowing in chronic pharyngeal Dysphagia. AN - 85404731; pmid-16718620 AB - We tested two hypotheses using surface electrical stimulation in chronic pharyngeal dysphagia: that stimulation (1) lowered the hyoid bone and/or larynx when applied at rest, and (2) increased aspiration, penetration, or pharyngeal pooling during swallowing. Bipolar surface electrodes were placed on the skin overlying the submandibular and laryngeal regions. Maximum tolerated levels of stimulation were applied while patients held their mouth closed at rest. Videofluoroscopic recordings were used to measure hyoid movements in the superior-inferior and anterior-posterior dimensions and the subglottic air column position while stimulation was on or off. Patients swallowed 5 ml liquid when stimulation was off, at low sensory stimulation levels, and at maximum tolerated levels (motor). Speech pathologists, blinded to condition, tallied the frequency of aspiration, penetration, pooling, and esophageal entry from videofluorographic recordings of swallows. Only significant (p = 0.0175) hyoid depression occurred during stimulation at rest. Aspiration and pooling were significantly reduced only with low sensory threshold levels of stimulation (p = 0.025) and not during maximum levels of surface electrical stimulation. Those patients who had reduced aspiration and penetration during swallowing with stimulation had greater hyoid depression during stimulation at rest (p = 0.006). Stimulation may have acted to resist patients' hyoid elevation during swallowing. JF - Dysphagia AU - Ludlow, Christy L AU - Humbert, Ianessa AU - Saxon, Keith AU - Poletto, Christopher AU - Sonies, Barbara AU - Crujido, Lisa AD - Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland 20892, USA. ludlowc@ninds.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1 EP - 10 VL - 22 IS - 1 SN - 0179-051X, 0179-051X KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Chronic Disease KW - *Deglutition: physiology KW - *Deglutition Disorders: therapy KW - *Electric Stimulation: instrumentation KW - Female KW - Humans KW - Hyoid Bone: innervation KW - Larynx KW - Male KW - Middle Aged KW - *Pharynx: physiology KW - Pilot Projects KW - *Rest UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85404731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Dysphagia&rft.atitle=Effects+of+surface+electrical+stimulation+both+at+rest+and+during+swallowing+in+chronic+pharyngeal+Dysphagia.&rft.au=Ludlow%2C+Christy+L%3BHumbert%2C+Ianessa%3BSaxon%2C+Keith%3BPoletto%2C+Christopher%3BSonies%2C+Barbara%3BCrujido%2C+Lisa&rft.aulast=Ludlow&rft.aufirst=Christy&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Dysphagia&rft.issn=0179051X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: Laryngoscope. 2002 Dec;112(12):2204-10[12461342]; Cites: J Appl Physiol. 2003 Jan;94(1):128-34[12486019]; Cites: Dysphagia. 1997 Summer;12(3):161-6[9190102]; Cites: Neurogastroenterol Motil. 2003 Feb;15(1):69-77[12588471]; Cites: Am J Physiol Gastrointest Liver Physiol. 2004 Jan;286(1):G45-50[12946939]; Cites: J Auton Nerv Syst. 1984 May-Jun;10(3-4):225-33[6384335]; Cites: Dysphagia. 1996 Spring;11(2):93-8[8721066]; Cites: Respir Care. 2001 May;46(5):466-74[11309186]; Cites: J Psychiatr Res. 1975 Nov;12(3):189-98[1202204]; Cites: J Physiol. 2003 Jul 1;550(Pt 1):287-304[12754311] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Removal of arsenic as arsenite from groundwater/wastewater as stable metal ferrite AN - 807281718; 13840793 AB - This paper summarizes the results of the study on removal of arsenite ions in liquid medium at an ambient temperature by ferritization and its application in wastewater/groundwater treatment. X-ray Diffractometry (XRD), thermal analysis and dc resistivity measurement have characterized the ferruginous material (Arsenic ferrite) precipitated by both the aeration and ageing procedures. The laboratory scale experiments conducted with synthetic solution of arsenite at different concentration suggest that the arsenite ions can be effectively retrieved > 99%. The recovered arsenic ferrites may find commercial application as semiconductors, catalysts, metal scavengers, etc. JF - Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances & Environmental Engineering AU - Zade, Prashant D AU - Dharmadhikari, Dattatray M AD - National Institute of Miners' Health (NIMH), Nagpur, India Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1073 EP - 1079 PB - Taylor & Francis Group Ltd., 2 Park Square Oxford OX14 4RN UK VL - 42 IS - 8 SN - 1093-4529, 1093-4529 KW - Environment Abstracts; Water Resources Abstracts KW - Catalyst KW - ferritization KW - arsenite ions KW - metal ferrite KW - x-ray diffractometry KW - Metals KW - Ions KW - Arsenic KW - Water Pollution Treatment KW - Laboratory testing KW - Laboratories KW - Groundwater Pollution KW - Wastewater treatment KW - Resistivity KW - scavengers KW - X-rays KW - Catalysts KW - Groundwater KW - Wastewater KW - SW 3030:Effects of pollution KW - ENA 19:Water Pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807281718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Awaterresources&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.atitle=Removal+of+arsenic+as+arsenite+from+groundwater%2Fwastewater+as+stable+metal+ferrite&rft.au=Zade%2C+Prashant+D%3BDharmadhikari%2C+Dattatray+M&rft.aulast=Zade&rft.aufirst=Prashant&rft.date=2007-01-01&rft.volume=42&rft.issue=8&rft.spage=1073&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+A%3A+Toxic%2FHazardous+Substances+%26+Environmental+Engineering&rft.issn=10934529&rft_id=info:doi/10.1080%2F10934520701418565 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Number of references - 20 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Ions; Metals; Arsenic; Laboratory testing; Catalysts; Groundwater; Wastewater treatment; scavengers; Wastewater; X-rays; Water Pollution Treatment; Laboratories; Groundwater Pollution; Resistivity DO - http://dx.doi.org/10.1080/10934520701418565 ER - TY - JOUR T1 - Regulation of Cartilaginous ECM Gene Transcription by Chondrocytes and MSCs in 3D Culture in Response to Dynamic Loading AN - 754884821; 13416360 AB - This study explored the biologic response of chondrocytes and mesenchymal stem cells (MSCs) to a dynamic mechanical loading regime. We developed a time-efficient methodology for monitoring regional changes in extracellular matrix gene transcription using reporter promoter constructs. Specifically, transfected cells were homogenously distributed throughout agarose hydrogel constructs, and spatial and temporal gene expression and the ability to form functional ECM were analyzed in response to dynamic mechanical stimuli. Theoretical analyses were used to predict the physical signals generated within the gel in response to these loading regimes. Using a custom compression bioreactor system, changes in aggrecan and type II collagen promoter activity in transfected chondrocyte-laden cylindrical constructs were evaluated in response to a range of loading frequencies and durations. In general, aggrecan promoter activity increased with increasing duration of loading, particularly in the outer annulus region. Interestingly, type II collagen promoter activity decreased in this annular region under identical loading conditions. In addition, we explored the role of mechanical compression in directing chondrogenic differentiation of MSCs by monitoring short-term aggrecan promoter activity. As an example of long-term utility, a specific loading protocol was applied to MSC-laden constructs for 5days, and the resultant changes in glycosaminoglycan (GAG) production were evaluated over a 4-week period. This dynamic loading regime increased not only short-term aggrecan transcriptional activity but also GAG deposition in long-term culture. These results demonstrate the utility of a new reporter promoter system for optimizing loading protocols to improve the outcome of engineered chondrocyte- and MSC-laden cartilaginous constructs. JF - Biomechanics and Modeling in Mechanobiology AU - Mauck, R L AU - Byers, BA AU - Yuan, X AU - Tuan, R S AD - Department of Health and Human Services Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 50 South Drive, MSC 8022, Building 50, Room 1503, Bethesda, MD, 20892-8022, USA, tuanr@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 113 EP - 125 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 6 IS - 1-2 SN - 1617-7959, 1617-7959 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Mechanical loading KW - Chondrocytes KW - Transcription KW - Cell culture KW - Compression KW - Mechanical stimuli KW - Gene expression KW - Promoters KW - Differentiation KW - Stem cells KW - Glycosaminoglycans KW - hydrogels KW - Bioreactors KW - Extracellular matrix KW - Collagen (type II) KW - Mesenchyme KW - aggrecan KW - Mechanical properties KW - N3 11023:Neurogenetics KW - T 2030:Cartilage and Cartilage Diseases KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754884821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomechanics+and+Modeling+in+Mechanobiology&rft.atitle=Regulation+of+Cartilaginous+ECM+Gene+Transcription+by+Chondrocytes+and+MSCs+in+3D+Culture+in+Response+to+Dynamic+Loading&rft.au=Mauck%2C+R+L%3BByers%2C+BA%3BYuan%2C+X%3BTuan%2C+R+S&rft.aulast=Mauck&rft.aufirst=R&rft.date=2007-01-01&rft.volume=6&rft.issue=1-2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Biomechanics+and+Modeling+in+Mechanobiology&rft.issn=16177959&rft_id=info:doi/10.1007%2Fs10237-006-0042-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2015-03-19 N1 - SubjectsTermNotLitGenreText - Mechanical loading; Transcription; Chondrocytes; Cell culture; Mechanical stimuli; Compression; Gene expression; Differentiation; Promoters; Stem cells; Glycosaminoglycans; hydrogels; Extracellular matrix; Bioreactors; Collagen (type II); aggrecan; Mesenchyme; Mechanical properties DO - http://dx.doi.org/10.1007/s10237-006-0042-1 ER - TY - JOUR T1 - Parallel analysis of tetramerization domain mutants of the human p53 protein using PCR colonies. AN - 733744408; 18923936 AB - A highly-parallel yeast functional assay, capable of screening approximately 100-1,000 mutants in parallel and designed to screen the activity of transcription activator proteins, was utilized to functionally characterize tetramerization domain mutants of the human p53 transcription factor and tumor suppressor protein. A library containing each of the 19 possible single amino acid substitutions (57 mutants) at three positions in the tetramerization domain of the human p53 protein, was functionally screened in Saccharomyces cerevisiae. Amino acids Leu330 and Ile332, whose side chains form a portion of a hydrophobic pocket that stabilizes the active p53 tetramer, were found to tolerate most hydrophobic amino acid substitutions while hydrophilic substitutions resulted in the inactivation of the protein. Amino acid Gln331 tolerated essentially all mutations. Importantly, highly parallel mutagenesis and cloning techniques were utilized which, in conjunction with recently reported highly parallel DNA sequencing methods, would be capable of increasing throughput an additional 2-3 orders of magnitude. JF - Genomic medicine AU - Merritt, Joshua AU - Roberts, Kim G AU - Butz, James A AU - Edwards, Jeremy S AD - Vaccine Research Center, NIAID, NIH, Bethesda, MD, 20892, USA, merrittj@niaid.nih.gov. Y1 - 2007 PY - 2007 DA - 2007 SP - 113 EP - 124 VL - 1 IS - 3-4 SN - 1871-7934, 1871-7934 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733744408?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genomic+medicine&rft.atitle=Parallel+analysis+of+tetramerization+domain+mutants+of+the+human+p53+protein+using+PCR+colonies.&rft.au=Merritt%2C+Joshua%3BRoberts%2C+Kim+G%3BButz%2C+James+A%3BEdwards%2C+Jeremy+S&rft.aulast=Merritt&rft.aufirst=Joshua&rft.date=2007-01-01&rft.volume=1&rft.issue=3-4&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Genomic+medicine&rft.issn=18717934&rft_id=info:doi/10.1007%2Fs11568-007-9011-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-07-14 N1 - Date created - 2008-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Biotechnol Bioeng. 2004 Apr 20;86(2):117-24 [15052631] Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9934-9 [12909720] Anal Biochem. 2003 Sep 1;320(1):55-65 [12895469] Nucleic Acids Res. 2003 Aug 1;31(15):e84 [12888536] Mol Cell Biol. 2002 Dec;22(24):8612-25 [12446780] J Mol Microbiol Biotechnol. 2002 Nov;4(6):539-50 [12432954] Oncogene. 2001 Jun 14;20(27):3573-9 [11429705] Oncogene. 2001 May 10;20(21):2611-7 [11420672] Nature. 2001 Feb 15;409(6822):860-921 [11237011] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Int J Cancer. 1999 Dec 22;84(6):587-93 [10567903] Nucleic Acids Res. 1999 Dec 15;27(24):e34 [10572186] Biotechnol Bioeng. 2005 Dec 5;92(5):519-31 [16193512] Science. 2005 Sep 9;309(5741):1728-32 [16081699] Proc Natl Acad Sci U S A. 2005 May 3;102(18):6431-6 [15843459] Hum Mutat. 1999;14(1):1-8 [10447253] J Mol Biol. 1999 May 21;288(5):891-7 [10329187] Nature. 1999 Apr 15;398(6728):545-6 [10217129] Int J Cancer. 1998 Oct 29;78(3):372-6 [9766574] Mol Carcinog. 1997 Aug;19(4):243-53 [9290701] Genes Dev. 1996 May 1;10(9):1054-72 [8654922] J Biol Chem. 1996 Apr 26;271(17):10017-22 [8626555] Proc Natl Acad Sci U S A. 1995 Apr 25;92(9):3963-7 [7732013] Nucleic Acids Res. 1992 Apr 11;20(7):1539-45 [1579447] Science. 1991 Jun 21;252(5013):1708-11 [2047879] Metab Eng. 2004 Jul;6(3):212-9 [15256211] N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1007/s11568-007-9011-8 ER - TY - CONF T1 - Workshop on imaging science development for cancer prevention and preemption. AN - 70759456; 17655039 AB - The concept of intraepithelial neoplasm (IEN) as a near-obligate precursor of cancers has generated opportunities to examine drug or device intervention strategies that may reverse or retard the sometimes lengthy process of carcinogenesis. Chemopreventive agents with high therapeutic indices, well-monitored for efficacy and safety, are greatly needed, as is development of less invasive or minimally disruptive visualization and assessment methods to safely screen nominally healthy but at-risk patients, often for extended periods of time and at repeated intervals. Imaging devices, alone or in combination with anticancer drugs, may also provide novel interventions to treat or prevent precancer. JF - Cancer biomarkers : section A of Disease markers AU - Kelloff, Gary J AU - Sullivan, Daniel C AU - Baker, Houston AU - Clarke, Lawrence P AU - Nordstrom, Robert AU - Tatum, James L AU - Dorfman, Gary S AU - Jacobs, Paula AU - Berg, Christine D AU - Pomper, Martin G AU - Birrer, Michael J AU - Tempero, Margaret AU - Higley, Howard R AU - Petty, Brenda Gumbs AU - Sigman, Caroline C AU - Maley, Carlo AU - Sharma, Prateek AU - Wax, Adam AU - Ginsberg, Gregory G AU - Dannenberg, Andrew J AU - Hawk, Ernest T AU - Messing, Edward M AU - Grossman, H Barton AU - Harisinghani, Mukesh AU - Bigio, Irving J AU - Griebel, Donna AU - Henson, Donald E AU - Fabian, Carol J AU - Ferrara, Katherine AU - Fantini, Sergio AU - Schnall, Mitchell D AU - Zujewski, Jo Anne AU - Hayes, Wendy AU - Klein, Eric A AU - DeMarzo, Angelo AU - Ocak, Iclal AU - Ketterling, Jeffrey A AU - Tempany, Clare AU - Shtern, Faina AU - Parnes, Howard L AU - Gomez, Jorge AU - Srivastava, Sudhir AU - Szabo, Eva AU - Lam, Stephen AU - Seibel, Eric J AU - Massion, Pierre AU - McLennan, Geoffrey AU - Cleary, Kevin AU - Suh, Robert AU - Burt, Randall W AU - Pfeiffer, Ruth M AU - Hoffman, John M AU - Roy, Hemant K AU - Wang, Thomas AU - Limburg, Paul J AU - El-Deiry, Wafik S AU - Papadimitrakopoulou, Vali AU - Hittelman, Walter N AU - MacAulay, Calum AU - Veltri, Robert W AU - Solomon, Diane AU - Jeronimo, Jose AU - Richards-Kortum, Rebecca AU - Johnson, Karen A AU - Viner, Jaye L AU - Stratton, Steven P AU - Rajadhyaksha, Milind AU - Dhawan, Atam AU - Workshop Program Committee Y1 - 2007 PY - 2007 DA - 2007 SP - 1 EP - 33 VL - 3 IS - 1 KW - Index Medicus KW - Image Interpretation, Computer-Assisted KW - Humans KW - Neoplasms -- diagnosis KW - Precancerous Conditions -- prevention & control KW - Precancerous Conditions -- diagnosis KW - Neoplasms -- prevention & control KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70759456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Cancer+biomarkers+%3A+section+A+of+Disease+markers&rft.atitle=Workshop+on+imaging+science+development+for+cancer+prevention+and+preemption.&rft.au=Kelloff%2C+Gary+J%3BSullivan%2C+Daniel+C%3BBaker%2C+Houston%3BClarke%2C+Lawrence+P%3BNordstrom%2C+Robert%3BTatum%2C+James+L%3BDorfman%2C+Gary+S%3BJacobs%2C+Paula%3BBerg%2C+Christine+D%3BPomper%2C+Martin+G%3BBirrer%2C+Michael+J%3BTempero%2C+Margaret%3BHigley%2C+Howard+R%3BPetty%2C+Brenda+Gumbs%3BSigman%2C+Caroline+C%3BMaley%2C+Carlo%3BSharma%2C+Prateek%3BWax%2C+Adam%3BGinsberg%2C+Gregory+G%3BDannenberg%2C+Andrew+J%3BHawk%2C+Ernest+T%3BMessing%2C+Edward+M%3BGrossman%2C+H+Barton%3BHarisinghani%2C+Mukesh%3BBigio%2C+Irving+J%3BGriebel%2C+Donna%3BHenson%2C+Donald+E%3BFabian%2C+Carol+J%3BFerrara%2C+Katherine%3BFantini%2C+Sergio%3BSchnall%2C+Mitchell+D%3BZujewski%2C+Jo+Anne%3BHayes%2C+Wendy%3BKlein%2C+Eric+A%3BDeMarzo%2C+Angelo%3BOcak%2C+Iclal%3BKetterling%2C+Jeffrey+A%3BTempany%2C+Clare%3BShtern%2C+Faina%3BParnes%2C+Howard+L%3BGomez%2C+Jorge%3BSrivastava%2C+Sudhir%3BSzabo%2C+Eva%3BLam%2C+Stephen%3BSeibel%2C+Eric+J%3BMassion%2C+Pierre%3BMcLennan%2C+Geoffrey%3BCleary%2C+Kevin%3BSuh%2C+Robert%3BBurt%2C+Randall+W%3BPfeiffer%2C+Ruth+M%3BHoffman%2C+John+M%3BRoy%2C+Hemant+K%3BWang%2C+Thomas%3BLimburg%2C+Paul+J%3BEl-Deiry%2C+Wafik+S%3BPapadimitrakopoulou%2C+Vali%3BHittelman%2C+Walter+N%3BMacAulay%2C+Calum%3BVeltri%2C+Robert+W%3BSolomon%2C+Diane%3BJeronimo%2C+Jose%3BRichards-Kortum%2C+Rebecca%3BJohnson%2C+Karen+A%3BViner%2C+Jaye+L%3BStratton%2C+Steven+P%3BRajadhyaksha%2C+Milind%3BDhawan%2C+Atam%3BWorkshop+Program+Committee&rft.aulast=Kelloff&rft.aufirst=Gary&rft.date=2007-01-01&rft.volume=3&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Cancer+biomarkers+%3A+section+A+of+Disease+markers&rft.issn=15740153&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-14 N1 - Date created - 2007-07-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Physiological and pathological brain hyperthermia. AN - 70751625; 17645922 AB - While brain temperature is usually considered a stable, tightly regulated parameter, recent animal research revealed relatively large and rapid brain temperature fluctuations (approximately 3 degrees C) during various forms of naturally occurring physiological and behavioral activities. This work demonstrates that physiological brain hyperthermia has an intra-brain origin, resulting from enhanced neural metabolism and increased intra-brain heat production, and discusses its possible mechanisms and functional consequences. This work also shows that brain hyperthermia may also be induced by various drugs of abuse. While each individual drug (i.e., heroin, cocaine, meth-amphetamine, MDMA) has its own, dose-dependent effects on brain and body temperatures, these effects are strongly modulated by the individual's activity state and environmental conditions, showing dramatic alterations during the development of drug-taking behavior. While brain temperatures may also increase due to environmental overheating and diminished heat dissipation from the brain, adverse environmental conditions and physiological activation strongly potentiate thermal effects of psychomotor stimulant drugs, resulting in dangerous brain overheating. Since hyperthermia exacerbates drug-induced toxicity and is destructive to neural cells and brain functions, use of these drugs under conditions that restrict heat loss may pose a significant health risk, resulting in both acute life-threatening complications and chronic destructive CNS changes. We argue that brain temperature is an important physiological parameter, affecting various neural functions, and show the potential of brain temperature monitoring for studying alterations in metabolic neural activity under physiological and pathological conditions. Finally, we discuss brain temperature as a factor affecting various neuronal and neurochemical evaluations made in different animal preparations (in vitro slices, general anesthesia, awake, freely moving conditions) and consider a possible contribution of temperature fluctuations to behavior-related and drug-induced alterations in neuronal and neurochemical parameters. JF - Progress in brain research AU - Kiyatkin, Eugene A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, DHHS, Baltimore, MD 21224, USA. ekiyatki@intra.nida.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 219 EP - 243 VL - 162 SN - 0079-6123, 0079-6123 KW - Index Medicus KW - Animals KW - Humans KW - Fever -- pathology KW - Brain -- pathology KW - Fever -- physiopathology KW - Brain -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70751625?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+brain+research&rft.atitle=Physiological+and+pathological+brain+hyperthermia.&rft.au=Kiyatkin%2C+Eugene+A&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2007-01-01&rft.volume=162&rft.issue=&rft.spage=219&rft.isbn=&rft.btitle=&rft.title=Progress+in+brain+research&rft.issn=00796123&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-07 N1 - Date created - 2007-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiple functions for the N-terminal region of Msh6. AN - 70716903; 17567610 AB - The eukaryotic mismatch repair protein Msh6 shares five domains in common with other MutS members. However, it also contains several hundred additional residues at its N-terminus. A few of these residues bind to PCNA, but the functions of the other amino acids in the N-terminal region (NTR) are unknown. Here we demonstrate that the Msh6 NTR binds to duplex DNA in a salt-sensitive, mismatch-independent manner. Partial proteolysis, DNA affinity chromatography and mass spectrometry identified a fragment comprised of residues 228-299 of yeast Msh6 that binds to DNA and is rich in positively charged residues. Deleting these residues, or replacing lysines and arginines with glutamate, reduces DNA binding in vitro and elevates spontaneous mutation rates and resistance to MNNG treatment in vivo. Similar in vivo defects are conferred by alanine substitutions in a highly conserved motif in the NTR that immediately precedes domain I of MutS proteins, the domain that interacts with mismatched DNA. These data suggest that, in addition to PCNA binding, DNA binding and possibly other functions in the amino terminal region of Msh6 are important for eukaryotic DNA mismatch repair and cellular response to alkylation damage. JF - Nucleic acids research AU - Clark, Alan B AU - Deterding, Leesa AU - Tomer, Kenneth B AU - Kunkel, Thomas A AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 4114 EP - 4123 VL - 35 IS - 12 KW - DNA-Binding Proteins KW - 0 KW - G-T mismatch-binding protein KW - MSH6 protein, S cerevisiae KW - Peptides KW - Saccharomyces cerevisiae Proteins KW - Methylnitronitrosoguanidine KW - 12H3O2UGSF KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Methylnitronitrosoguanidine -- toxicity KW - DNA Mismatch Repair KW - Conserved Sequence KW - Amino Acid Motifs KW - DNA -- metabolism KW - Molecular Sequence Data KW - Peptides -- metabolism KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Mutation, Missense KW - Sequence Deletion KW - Binding Sites KW - Saccharomyces cerevisiae Proteins -- metabolism KW - DNA-Binding Proteins -- chemistry KW - Saccharomyces cerevisiae Proteins -- genetics KW - DNA-Binding Proteins -- genetics KW - Saccharomyces cerevisiae Proteins -- chemistry KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70716903?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Multiple+functions+for+the+N-terminal+region+of+Msh6.&rft.au=Clark%2C+Alan+B%3BDeterding%2C+Leesa%3BTomer%2C+Kenneth+B%3BKunkel%2C+Thomas+A&rft.aulast=Clark&rft.aufirst=Alan&rft.date=2007-01-01&rft.volume=35&rft.issue=12&rft.spage=4114&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Cancer. 2000 Mar 1;85(5):606-13 [10699937] Cancer Res. 1999 Oct 15;59(20):5068-74 [10537275] Nature. 2000 Oct 12;407(6805):711-7 [11048711] Nat Genet. 2000 Nov;26(3):375-8 [11062484] J Biol Chem. 2000 Nov 24;275(47):36498-501 [11005803] Genes Dev. 2001 Mar 15;15(6):724-36 [11274057] J Mol Biol. 2001 Sep 28;312(4):637-47 [11575920] Free Radic Biol Med. 2002 Aug 1;33(3):364-9 [12126758] J Mol Biol. 2003 Jul 11;330(3):571-6 [12842472] Annu Rev Microbiol. 2003;57:579-608 [14527292] Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14822-7 [14634210] Genet Eng (N Y). 2003;25:189-207 [15260239] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6424-8 [8341649] Mol Cell Biol. 1998 Apr;18(4):1891-902 [9528760] Nucleic Acids Res. 1999 Feb 1;27(3):736-42 [9889267] Mol Cell Biol. 1999 Mar;19(3):2000-7 [10022887] Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2970-5 [10077621] Am J Hum Genet. 1999 Nov;65(5):1291-8 [10521294] Annu Rev Biochem. 2005;74:681-710 [15952900] Curr Biol. 2005 Aug 9;15(15):1395-400 [16085492] DNA Repair (Amst). 2005 Dec 8;4(12):1410-20 [16226493] Chem Rev. 2006 Feb;106(2):302-23 [16464007] Nat Rev Mol Cell Biol. 2006 May;7(5):335-46 [16612326] Nature. 2000 Oct 12;407(6805):703-10 [11048710] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction. AN - 70690439; 17627675 AB - As a continuation of our work with SB-277011A, we have examined the effects of another highly elective dopamine (DA) D3 receptor antagonist, N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-2-fluorenylcarboxamide (NGB 2904), in animal models of addiction. Our results indicate that by systemic administration, NGB 2904 inhibits intravenous cocaine self-administration maintained under a progressive-ratio (PR) reinforcement schedule, cocaine- or cocaine cue-induced reinstatement of cocaine-seeking behavior, and cocaine- or other addictive drug-enhanced brain stimulation reward (BSR). The action of NGB 2904 on PR cocaine self-administration was long-lasting (1-2 days) after a single injection, supporting its potential use in treatment of cocaine addiction. The effects of NGB 2904 in the BSR paradigm were dose-dependent for both NGB 2904 and cocaine; that is, only lower doses of NGB 2904 were effective, and their putative antiaddiction effect could be overcome by increasing the doses of cocaine or other addictive drugs. A dopamine-dependent mechanism is proposed to explain the effects of NGB 2904 on cocaine's actions in these animal models of drug addiction. The data reviewed in this paper suggest that NGB 2904 or other D3-selective antagonists may have potential in controlling motivation for drug-taking behavior or relapse to drug-seeking behavior, but may have a limited role in antagonizing the acute rewarding effects produced by cocaine or other addictive drugs. In addition, NGB 2904 may also act as a useful tool to study the role of D3 receptors in drug addiction. JF - CNS drug reviews AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD, USA. zxi@intra.nida.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 240 EP - 259 VL - 13 IS - 2 SN - 1080-563X, 1080-563X KW - BP 897 KW - 0 KW - Dopamine Antagonists KW - Fluorenes KW - NGB 2904 KW - Piperazines KW - Receptors, Dopamine D3 KW - Index Medicus KW - Rats KW - Animals KW - Disease Models, Animal KW - Fluorenes -- pharmacology KW - Dopamine Antagonists -- therapeutic use KW - Piperazines -- therapeutic use KW - Dopamine Antagonists -- pharmacology KW - Receptors, Dopamine D3 -- antagonists & inhibitors KW - Substance-Related Disorders -- drug therapy KW - Behavior, Addictive -- drug therapy KW - Piperazines -- pharmacology KW - Fluorenes -- therapeutic use KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70690439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=CNS+drug+reviews&rft.atitle=Pharmacological+actions+of+NGB+2904%2C+a+selective+dopamine+D3+receptor+antagonist%2C+in+animal+models+of+drug+addiction.&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2007-01-01&rft.volume=13&rft.issue=2&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=CNS+drug+reviews&rft.issn=1080563X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-21 N1 - Date created - 2007-07-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1998 Oct;139(3):169-84 [9784071] Eur J Pharmacol. 2001 Jul 20;424(2):85-90 [11476753] J Med Chem. 2001 Sep 13;44(19):3175-86 [11543687] Xenobiotica. 2001 Aug-Sep;31(8-9):677-86 [11569533] Neuroscience. 2001;107(4):629-39 [11720786] Curr Opin Investig Drugs. 2001 Jul;2(7):946-9 [11757796] Pharmacol Rev. 2002 Mar;54(1):1-42 [11870259] Psychopharmacology (Berl). 2002 Oct;163(3-4):265-82 [12373428] J Neurosci. 2002 Nov 1;22(21):9595-603 [12417684] Neuroreport. 2003 Jan 20;14(1):93-8 [12544838] J Neurosci. 2003 Feb 1;23(3):1006-12 [12574430] Synapse. 2005 Jul;57(1):17-28 [15858839] Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8 [9873609] Nature. 1999 Jul 22;400(6742):371-5 [10432116] J Med Chem. 2005 Feb 10;48(3):839-48 [15689168] J Psychopharmacol. 1999 Dec;13(4):337-45 [10667609] J Med Chem. 2000 May 4;43(9):1878-85 [10794704] J Pharmacol Exp Ther. 2000 Sep;294(3):1154-65 [10945872] Eur J Pharmacol. 2000 Oct 27;407(1-2):47-51 [11050289] J Pharmacol Exp Ther. 2000 Dec;295(3):1223-31 [11082459] J Neurosci. 2000 Dec 1;20(23):8677-84 [11102473] Am J Addict. 2000 Fall;9(4):285-313 [11155784] Psychopharmacology (Berl). 2000 Dec;153(1):1-16 [11255919] Psychiatry Res. 2001 Jul 24;102(3):227-33 [11440773] Psychopharmacology (Berl). 2001 Jun;155(4):330-7 [11441422] Acta Psychiatr Scand Suppl. 2005;(427):14-21 [15877719] J Med Chem. 2005 Jun 2;48(11):3663-79 [15916415] Brain Res Brain Res Rev. 2005 Jul;49(1):77-105 [15960988] J Pharmacol Exp Ther. 2005 Jul;314(1):310-9 [15833897] Drug Discov Today. 2005 Jul 1;10(13):917-25 [15993811] Eur J Neurosci. 2005 Jun;21(12):3427-38 [16026480] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Neuropharmacology. 2005 Sep;49(4):525-41 [15963538] Neuropsychopharmacology. 2005 Aug;30(8):1455-63 [15702135] Pharmacol Ther. 2005 Oct;108(1):18-58 [16183393] J Comp Neurol. 2005 Dec 5;493(1):115-21 [16254990] Neurosci Biobehav Rev. 2006;30(2):215-38 [16099045] CNS Neurol Disord Drug Targets. 2006 Feb;5(1):25-43 [16613552] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Neuropsychopharmacology. 2006 Jul;31(7):1393-405 [16205781] AAPS J. 2006;8(2):E413-8 [16808044] Philos Trans R Soc Lond B Biol Sci. 2006 Jul 29;361(1471):1149-58 [16874930] Pharmacol Ther. 2006 Oct;112(1):281-333 [16905195] Int J Neuropsychopharmacol. 2006 Oct;9(5):585-602 [16942635] J Pharmacol Exp Ther. 2007 May;321(2):573-82 [17272677] Pharmacol Biochem Behav. 2007 Apr;86(4):718-26 [17408730] Psychopharmacology (Berl). 2008 Mar;196(4):533-42 [17985117] Neuropsychopharmacology. 2003 Feb;28(2):329-38 [12589386] Bioorg Med Chem Lett. 2003 Jul 7;13(13):2179-83 [12798330] CNS Drug Rev. 2003 Summer;9(2):141-58 [12847556] Am J Addict. 2003;12 Suppl 2:S36-47 [12857662] J Med Chem. 2003 Aug 28;46(18):3822-39 [12930145] Brain Res Bull. 2003 Oct 15;61(6):595-601 [14519456] Neuropsychopharmacology. 2003 Nov;28(11):1903-15 [12915863] Prog Neuropsychopharmacol Biol Psychiatry. 2003 Oct;27(7):1081-90 [14642968] Neurosci Biobehav Rev. 2004 Jan;27(8):777-86 [15019427] Arch Neurol. 2004 May;61(5):641-4 [15148138] Drugs. 2004;64(14):1547-73 [15233592] Neuropsychopharmacology. 2004 Aug;29(8):1479-87 [15100700] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Pharmacol Biochem Behav. 1993 Feb;44(2):487-9 [8095344] Science. 1993 Jun 18;260(5115):1814-6 [8099761] Pharmacol Biochem Behav. 1995 Nov;52(3):503-8 [8545466] Mol Neurobiol. 1995 Aug-Dec;11(1-3):1-19 [8561954] Curr Opin Neurobiol. 1996 Apr;6(2):243-51 [8725967] Trends Pharmacol Sci. 1996 Jul;17(7):260-4 [8756185] J Neurosci Methods. 1996 May;66(1):1-11 [8794935] J Neurosci. 1996 Oct 1;16(19):6100-6 [8815892] Annu Rev Neurosci. 1996;19:319-40 [8833446] Neuropsychopharmacology. 1996 Nov;15(5):506-14 [8914124] Pharmacol Rev. 1997 Sep;49(3):231-52 [9311022] J Pharmacol Exp Ther. 1997 Dec;283(3):1160-7 [9399989] Crit Rev Neurobiol. 1998;12(1-2):37-67 [9444481] Dev Neurosci. 1998;20(2-3):188-203 [9691193] Mol Psychiatry. 1998 Jul;3(4):333-6 [9702742] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates. AN - 70681925; 17567611 AB - The Cockayne syndrome B (CSB) protein--defective in a majority of patients suffering from the rare autosomal disorder CS--is a member of the SWI2/SNF2 family with roles in DNA repair and transcription. We demonstrate herein that purified recombinant CSB and the major human apurinic/apyrimidinic (AP) endonuclease, APE1, physically and functionally interact. CSB stimulates the AP site incision activity of APE1 on normal (i.e. fully paired) and bubble AP-DNA substrates, with the latter being more pronounced (up to 6-fold). This activation is ATP-independent, and specific for the human CSB and full-length APE1 protein, as no CSB-dependent stimulation was observed with Escherichia coli endonuclease IV or an N-terminal truncated APE1 fragment. CSB and APE1 were also found in a common protein complex in human cell extracts, and recombinant CSB, when added back to CSB-deficient whole cell extracts, resulted in increased total AP site incision capacity. Moreover, human fibroblasts defective in CSB were found to be hypersensitive to both methyl methanesulfonate (MMS) and 5-hydroxymethyl-2'-deoxyuridine, agents that introduce base excision repair (BER) DNA substrates/intermediates. JF - Nucleic acids research AU - Wong, Heng-Kuan AU - Muftuoglu, Meltem AU - Beck, Gad AU - Imam, Syed Z AU - Bohr, Vilhelm A AU - Wilson, David M AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 4103 EP - 4113 VL - 35 IS - 12 KW - 5-hydroxymethyl-2'-deoxyuridine KW - 5116-24-5 KW - Methyl Methanesulfonate KW - AT5C31J09G KW - DNA Helicases KW - EC 3.6.4.- KW - ERCC6 protein, human KW - EC 3.6.4.12 KW - APEX1 protein, human KW - EC 4.2.99.18 KW - DNA-(Apurinic or Apyrimidinic Site) Lyase KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Methyl Methanesulfonate -- toxicity KW - Genome, Human KW - Thymidine -- toxicity KW - Humans KW - Cell Line, Transformed KW - Thymidine -- analogs & derivatives KW - DNA Repair Enzymes -- metabolism KW - DNA Repair KW - DNA-(Apurinic or Apyrimidinic Site) Lyase -- metabolism KW - DNA Helicases -- metabolism KW - DNA Helicases -- physiology KW - DNA Repair Enzymes -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70681925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+acids+research&rft.atitle=Cockayne+syndrome+B+protein+stimulates+apurinic+endonuclease+1+activity+and+protects+against+agents+that+introduce+base+excision+repair+intermediates.&rft.au=Wong%2C+Heng-Kuan%3BMuftuoglu%2C+Meltem%3BBeck%2C+Gad%3BImam%2C+Syed+Z%3BBohr%2C+Vilhelm+A%3BWilson%2C+David+M&rft.aulast=Wong&rft.aufirst=Heng-Kuan&rft.date=2007-01-01&rft.volume=35&rft.issue=12&rft.spage=4103&rft.isbn=&rft.btitle=&rft.title=Nucleic+acids+research&rft.issn=1362-4962&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-07 N1 - Date created - 2007-07-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1992 Dec;12(12):5536-40 [1448084] Cell. 1992 Dec 11;71(6):939-53 [1339317] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6601-5 [8341674] Environ Mol Mutagen. 1994;23(1):32-6 [7510226] Cancer Res. 1994 Sep 1;54(17):4627-34 [8062255] Mutat Res. 1994 Sep;325(1):39-45 [7521011] J Biol Chem. 1995 Jul 7;270(27):16002-7 [7608159] Nature. 1996 Jan 11;379(6561):183-6 [8538772] Mol Cell Biol. 1996 Aug;16(8):4436-44 [8754844] J Biol Chem. 1997 Jan 17;272(3):1885-90 [8999876] Nucleic Acids Res. 1998 Jun 1;26(11):2644-9 [9592149] Nucleic Acids Res. 1998 Jun 1;26(11):2771-8 [9592167] J Biol Chem. 1998 Oct 23;273(43):27794-9 [9774388] J Mol Biol. 2005 Feb 4;345(5):1003-14 [15644200] J Biol Chem. 2005 Feb 11;280(6):4722-9 [15548521] J Biol Chem. 2005 Apr 22;280(16):15773-85 [15701627] Nucleic Acids Res. 2005;33(10):3271-82 [15942030] Free Radic Biol Med. 2005 May 1;38(9):1121-38 [15808410] Nucleic Acids Res. 1997 Mar 1;25(5):933-9 [9023101] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4306-11 [9113985] EMBO J. 1997 Oct 1;16(19):5955-65 [9312053] Mol Cell Biol. 1997 Dec;17(12):6803-14 [9372911] Cancer Res. 1998 Jan 15;58(2):222-5 [9443396] J Biol Chem. 1998 May 8;273(19):11844-51 [9565609] J Cell Biochem. 2005 Jul 1;95(4):794-804 [15838887] Nature. 2005 Jun 23;435(7045):1015 [15973373] DNA Repair (Amst). 2005 Jul 28;4(8):919-25 [15961352] Nat Rev Cancer. 2005 Jul;5(7):564-73 [16069818] Mol Cell Biol. 2005 Sep;25(17):7625-36 [16107709] Nucleic Acids Res. 2005;33(15):4711-24 [16113242] FEBS J. 2005 Sep;272(17):4306-14 [16128801] Mutat Res. 2005 Sep 4;577(1-2):179-94 [16009385] Biochemistry. 2005 Nov 1;44(43):14335-43 [16245950] Mol Cell. 2005 Oct 28;20(2):187-98 [16246722] DNA Repair (Amst). 2006 Jan 5;5(1):13-22 [16129663] Cancer Res. 2006 Jan 1;66(1):113-24 [16397223] Nucleic Acids Res. 2006;34(1):295-304 [16410611] EMBO J. 2006 Jan 25;25(2):387-97 [16407975] Chem Res Toxicol. 2006 Feb;19(2):234-41 [16485899] Trends Genet. 2006 Aug;22(8):430-6 [16797777] Mol Cell. 2006 Aug;23(4):471-82 [16916636] Nucleic Acids Res. 2006;34(15):4160-7 [16935875] Chem Res Toxicol. 2006 Dec;19(12):1580-94 [17173371] Oncogene. 2007 Jun 7;26(27):4044-8 [17213818] Mol Biol Cell. 1999 Nov;10(11):3583-94 [10564257] Nature. 2000 Jan 27;403(6768):451-6 [10667800] Nucleic Acids Res. 2000 Aug 15;28(16):3151-9 [10931931] Mutat Res. 2000 Aug 30;460(3-4):211-29 [10946230] Mol Cell Biol. 2000 Oct;20(20):7643-53 [11003660] Mutat Res. 2001 May 10;485(4):283-307 [11585362] J Biol Chem. 2001 Nov 9;276(45):41991-7 [11526119] J Biol Chem. 2001 Dec 7;276(49):45772-9 [11581270] Nucleic Acids Res. 2002 Feb 1;30(3):782-93 [11809892] Gene. 2002 Jan 23;283(1-2):27-40 [11867210] Oncogene. 2002 May 16;21(22):3571-8 [12032859] Mol Cell. 2002 Oct;10(4):819-29 [12419226] Oncogene. 2002 Nov 28;21(54):8232-9 [12447686] Oncogene. 2002 Dec 12;21(57):8675-82 [12483520] Oncogene. 2002 Dec 16;21(58):8926-34 [12483509] DNA Repair (Amst). 2002 Aug 6;1(8):683-96 [12509290] DNA Repair (Amst). 2003 Jan 2;2(1):13-25 [12509265] DNA Repair (Amst). 2003 Jan 2;2(1):27-48 [12509266] Nucleic Acids Res. 2003 Feb 1;31(3):963-73 [12560492] FASEB J. 2003 Apr;17(6):668-74 [12665480] Mol Cell Biol. 2003 Sep;23(18):6385-95 [12944467] Nucleic Acids Res. 2003 Sep 15;31(18):5332-7 [12954769] Toxicology. 2003 Nov 15;193(1-2):79-90 [14599769] Am J Hum Genet. 2003 Dec;73(6):1217-39 [14639525] Nucleic Acids Res. 2004;32(1):73-81 [14704345] Biochimie. 2003 Nov;85(11):1101-11 [14726016] J Biol Chem. 2004 Apr 30;279(18):18511-20 [14978042] Environ Health Perspect. 2004 May;112(7):799-804 [15159209] J Cell Biol. 2004 Jul 5;166(1):27-36 [15226310] Anticancer Res. 2004 Jul-Aug;24(4):2127-34 [15330152] Mol Cell Biol. 2004 Sep;24(18):7941-8 [15340056] Biochim Biophys Acta. 1970 Sep 17;217(1):192-5 [5505330] Biochim Biophys Acta. 1972 Aug 25;277(2):276-9 [4342399] Cancer Res. 1982 Apr;42(4):1473-8 [6174225] Biochem J. 1985 Jul 1;229(1):173-81 [2412545] Exp Cell Res. 1986 Feb;162(2):530-8 [3002824] Mol Cell Biol. 1990 Dec;10(12):6160-71 [2247054] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complementary and alternative medicine (CAM) for the treatment of chronic hepatitis B and C: a review. AN - 70649734; 17591018 AB - Complementary and alternative medicine (CAM) has been used for centuries in China and Japan to treat various illnesses, including viral hepatitis. Several therapeutic approaches constitute CAM, the most relevant for this review being the use of herbals. However, profound disagreements exist between conventional and alternative medicine practitioners regarding their value. Western medical advocates cite deep concerns about the purity of most herbals because of lack of standardized production, the paucity of pharmacokinetic data, the fact that few well-designed randomized, controlled trials of these products have been performed and the evidence that some herbals have been responsible for severe adverse effects. Nevertheless, many in the public, even in western countries, turn to the use of herbals, believing that they must be safe and effective because they are 'natural' and have been used for centuries, and because of dissatisfaction with conventional medicine. Accordingly, their use in western countries and the costs incurred have increased each year. While there is evidence that some herbals have physiological effects, there still is insufficient evidence to recommend their use. This paper reviews the classification, epidemiology and philosophy of CAM, and the reasons advanced for herbal use to treat viral hepatitis. The criteria necessary to develop a potential pharmacological agent are presented, as well as the requirements for conducting a scientifically valid treatment trial of herbals. Five herbals used in the past to treat viral hepatitis are reviewed and evaluated for the quality of their studies and mention is made of herbals known to have adverse effects. JF - Antiviral therapy AU - Modi, Apurva A AU - Wright, Elizabeth C AU - Seeff, Leonard B AD - The National Institute of Diabetes and Digestive and Kidney Diseases, The National Institute of Health, Bethesda, MD, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 285 EP - 295 VL - 12 IS - 3 SN - 1359-6535, 1359-6535 KW - Plant Preparations KW - 0 KW - Index Medicus KW - Global Health KW - Animals KW - Phytotherapy -- economics KW - Costs and Cost Analysis KW - Plant Preparations -- adverse effects KW - Humans KW - Chemical and Drug Induced Liver Injury KW - Health Surveys KW - Herb-Drug Interactions KW - Drug Evaluation, Preclinical KW - Phytotherapy -- adverse effects KW - Hepatitis B, Chronic -- therapy KW - Complementary Therapies -- economics KW - Complementary Therapies -- classification KW - Complementary Therapies -- adverse effects KW - Hepatitis C, Chronic -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70649734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+therapy&rft.atitle=Complementary+and+alternative+medicine+%28CAM%29+for+the+treatment+of+chronic+hepatitis+B+and+C%3A+a+review.&rft.au=Modi%2C+Apurva+A%3BWright%2C+Elizabeth+C%3BSeeff%2C+Leonard+B&rft.aulast=Modi&rft.aufirst=Apurva&rft.date=2007-01-01&rft.volume=12&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Antiviral+therapy&rft.issn=13596535&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-06 N1 - Date created - 2007-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The use of bisphosphonates in cancer patients. AN - 70605666; 17562434 AB - Skeletal-related events resulting from bone metastases or osteoporosis can significantly contribute to morbidity and mortality in cancer patients. Expert opinion on the effectiveness of bisphosphonates in this setting is evolving. Here we review current evidence on the risks and benefits of bisphosphonate therapy for a wide variety of cancers, as well as clinical management of its adverse effects. A MEDLINE search of English-language literature (1966 through May 2006) was conducted using the terms bisphosphonate, cancer, multiple myeloma, malignancy, and randomized controlled clinical studies. Studies were selected based on clinical pertinence, with an emphasis on phase III clinical trials. We reviewed bibliographies for other relevant articles. Accumulating evidence reveals that bisphosphonate therapy has a significant effect in preventing skeletal complications in multiple myeloma, breast cancers, and prostate cancer, and in reducing skeletal complications in other metastatic bone malignancies. Emerging data indicate that bisphosphonates are useful for preventing bone loss resulting from cancer or its therapy. The efficacy of bisphosphonates for early-stage breast cancers remains controversial. Significant risks of bisphosphonate therapy include nephrotoxicity, electrolyte abnormalities, and osteonecrosis of the jaw. Bisphosphonate therapy has a clear role in the management of skeletal metastases associated with a variety of cancers. However, significant side effects require ongoing monitoring and treatment. JF - Acta oncologica (Stockholm, Sweden) AU - Wu, Shenhong AU - Dahut, William L AU - Gulley, James L AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 581 EP - 591 VL - 46 IS - 5 SN - 0284-186X, 0284-186X KW - Bone Density Conservation Agents KW - 0 KW - Diphosphonates KW - Index Medicus KW - Humans KW - Diphosphonates -- therapeutic use KW - Diphosphonates -- adverse effects KW - Bone Density Conservation Agents -- therapeutic use KW - Bone Diseases, Metabolic -- etiology KW - Bone Diseases, Metabolic -- drug therapy KW - Bone Neoplasms -- secondary KW - Bone Neoplasms -- complications KW - Bone Density Conservation Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70605666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.atitle=The+use+of+bisphosphonates+in+cancer+patients.&rft.au=Wu%2C+Shenhong%3BDahut%2C+William+L%3BGulley%2C+James+L&rft.aulast=Wu&rft.aufirst=Shenhong&rft.date=2007-01-01&rft.volume=46&rft.issue=5&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.issn=0284186X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-06 N1 - Date created - 2007-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer survivorship research: state of knowledge, challenges and opportunities. AN - 70490470; 17497308 AB - Seminal advances in early detection of and treatment strategies for cancer have led to burgeoning numbers of cancer survivors. While most therapeutic modalities for cancer are beneficial and lifesaving, they are associated with adverse long-term and late sequelae. Literature review using MEDLINE to identify studies examining adverse medical outcomes and post-treatment follow-up care among long-term survivors. Emerging concepts in survivorship research such as definitional issues, research paradigms and methodologic concerns were also examined. Long-term or late adverse sequelae are more prevalent, serious, and persistent than expected in survivors of pediatric and adult cancer, but remain understudied especially among those diagnosed as adults. Follow-up care relevant to survivorship outcomes is neither standardized nor guideline or evidence based for most adult cancers, and optimal practices have yet to be defined. Adverse sequelae contribute to burden of illness, health care costs, and decreased length and quality of survival. To-date, very few studies have compared survivor outcomes pre-and post diagnosis. It is critical to examine under-researched questions and understudied survivor groups. Regular follow-up care and monitoring of health status post cancer treatment should 1) permit the timely diagnosis and treatment of adverse outcomes; 2) enable timely diagnosis and treatment of recurrences; 3) facilitate screening and early detection of second cancer(s); 4) allow for detection and management of co-morbidities; and 5) provide the opportunity for preventive strategies such as lifestyle changes. Research findings to-date underscore the need for continued cancer survivorship research that will: inform our understanding of the mechanisms underlying adverse sequelae; lead to the design of less toxic treatments; test the effectiveness of interventions - medical, pharmacologic, and behavioral - that reduce adverse outcomes; test models of post-treatment follow-up care; develop an evidence base for optimal follow-up care practices; and inform survivor and provider decision making. JF - Acta oncologica (Stockholm, Sweden) AU - Aziz, Noreen M AD - Office of Cancer Survivorship, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892, USA. na45f@nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 417 EP - 432 VL - 46 IS - 4 SN - 0284-186X, 0284-186X KW - Index Medicus KW - Age Factors KW - Comorbidity -- trends KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Treatment Outcome KW - Radiotherapy -- adverse effects KW - Continuity of Patient Care KW - Neoplasms -- diagnosis KW - Neoplasms -- epidemiology KW - Research -- trends KW - Neoplasms -- therapy KW - Survivors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70490470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.atitle=Cancer+survivorship+research%3A+state+of+knowledge%2C+challenges+and+opportunities.&rft.au=Aziz%2C+Noreen+M&rft.aulast=Aziz&rft.aufirst=Noreen&rft.date=2007-01-01&rft.volume=46&rft.issue=4&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Acta+oncologica+%28Stockholm%2C+Sweden%29&rft.issn=0284186X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-06 N1 - Date created - 2007-05-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Contrast-enhanced sonography of the kidney. AN - 70477656; 17420958 AB - Contrast-enhanced sonography (CEUS) is a recently introduced, promising technique in the evaluation of the kidney. CEUS allows real-time assessment of normal and abnormal renal perfusions. As a consequence of the macrocirculation analysis allowed by Doppler techniques, it is possible to obtain real-time information about microcirculation. US contrast media are not nephrotoxic and can be employed safely, even in subjects with impaired renal function. There are several clinical scenarios where CEUS may play the role of a low-cost, scarcely invasive tool, including renal tumors (with special reference to small, indeterminate masses, i.e., differentiation between carcinoma and angiomyolipoma), renal atypical cystic masses (i.e., differentiation of malignant from benign cysts and follow-up of cystic lesions managed conservatively), renal infarction, renal infections, and renal injuries. In addition, CEUS can be useful in the assessment of renal pseudotumors (including any case with possible renal mass on conventional US imaging) and has been employed in radiofrequency ablation guidance. This pictorial review illustrates the CEUS findings recognizable in a wide spectrum of renal disorders and discusses the strengths and limitations of renal imaging with CEUS. JF - Abdominal imaging AU - Setola, S V AU - Catalano, O AU - Sandomenico, F AU - Siani, A AD - Department of Radiology, National Cancer Institute Fondazione Pascale, via M.Semmola, Naples, I-80131, Italy. sesetol@tin.it PY - 2007 SP - 21 EP - 28 VL - 32 IS - 1 SN - 0942-8925, 0942-8925 KW - Contrast Media KW - 0 KW - Phospholipids KW - contrast agent BR1 KW - Sulfur Hexafluoride KW - WS7LR3I1D6 KW - Index Medicus KW - Ultrasonography, Interventional KW - Pyelonephritis -- diagnostic imaging KW - Humans KW - Ultrasonography, Doppler -- methods KW - Aged KW - Kidney Neoplasms -- diagnostic imaging KW - Microbubbles KW - Carcinoma -- diagnostic imaging KW - Microcirculation -- diagnostic imaging KW - Adult KW - Kidney Diseases, Cystic -- diagnostic imaging KW - Middle Aged KW - Angiomyolipoma -- diagnostic imaging KW - Infarction -- diagnostic imaging KW - Catheter Ablation KW - Female KW - Male KW - Kidney -- diagnostic imaging KW - Kidney -- injuries KW - Kidney -- blood supply KW - Kidney Diseases -- diagnostic imaging KW - Image Enhancement -- methods KW - Kidney Diseases -- microbiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70477656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Abdominal+imaging&rft.atitle=Contrast-enhanced+sonography+of+the+kidney.&rft.au=Setola%2C+S+V%3BCatalano%2C+O%3BSandomenico%2C+F%3BSiani%2C+A&rft.aulast=Setola&rft.aufirst=S&rft.date=2007-01-01&rft.volume=32&rft.issue=1&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Abdominal+imaging&rft.issn=09428925&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. AN - 70468003; 17418982 AB - Dietary flavone was previously shown to increase the expression of deleted in liver cancer-1 gene (DLC-1) in HT-29 colon carcinoma cell line [Herzog A, Kindermann B, Doring F, Daniel H, Wenzel U. Pleiotropic molecular effects of the pro-apoptotic dietary constituent flavone in human colon cancer cells identified by protein and mRNA expression profiling. Proteomics 2004;4:2455-64]. DLC-1 that encodes a Rho GTPase-activating protein, functions as a tumor suppressor gene and is frequently inactivated or down-regulated in several common cancers. Restoration of DLC-1 expression suppresses in vitro tumor cells proliferation and tumorigenicity in vivo. Here, the effect of flavone was examined in several DLC-1-deficient cell lines derived from different types human cancer using assays for cell proliferation, gene expression and transfer. We show that exposure to 150 microM flavone increased DLC1 expression in breast but not in liver or prostate carcinoma cells or a nonmalignant breast epithelial cell line. Flavone restored the expression of DLC1 in the breast carcinoma cell lines MDA-MB-468, MDA-MB-361, and BT20 as well as in the colon carcinoma cell line HT-29 all of which are DLC-1-negative due to promoter hypermethylation. We further show that flavone inhibited cell proliferation, induced cell cycle arrest at G(2)-M, increased p21(Waf1) gene expression, and caused apoptosis. Microarray analysis of these aggressive and metastatic breast carcinoma cells revealed 29 flavone-responsive genes, among which the DNA damage-inducible GADD genes were up-regulated and the proto-oncogene STMN1 and IGFBP3 were down-regulated. Flavone-mediated alterations of genes that regulate tumor cell proliferation, cell cycle, and apoptosis contribute to chemopreventive and antitumoral effects of flavone. Alone or in combination with demethylating agents, flavone may be an effective adjunct to chemotherapy in preventing breast cancer metastasis. JF - Cancer detection and prevention AU - Ullmannova, Veronika AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, MSC 4264, Bethesda, MD 20892-4255, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 110 EP - 118 VL - 31 IS - 2 SN - 0361-090X, 0361-090X KW - Biomarkers, Tumor KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DLC1 protein, human KW - Flavones KW - GTPase-Activating Proteins KW - Tumor Suppressor Proteins KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Immunoblotting KW - Oligonucleotide Array Sequence Analysis KW - Genes, Tumor Suppressor KW - Humans KW - Reverse Transcriptase Polymerase Chain Reaction KW - Biomarkers, Tumor -- metabolism KW - Gene Expression Profiling KW - Tumor Cells, Cultured KW - DNA Methylation KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism KW - Flow Cytometry KW - Cell Cycle KW - Male KW - Female KW - Caspase 3 -- metabolism KW - Cell Proliferation -- drug effects KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- pathology KW - Tumor Suppressor Proteins -- metabolism KW - Apoptosis -- drug effects KW - Tumor Suppressor Proteins -- genetics KW - Breast Neoplasms -- metabolism KW - Flavones -- pharmacology KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70468003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+detection+and+prevention&rft.atitle=Inhibition+of+cell+proliferation%2C+induction+of+apoptosis%2C+reactivation+of+DLC1%2C+and+modulation+of+other+gene+expression+by+dietary+flavone+in+breast+cancer+cell+lines.&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicholas+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2007-01-01&rft.volume=31&rft.issue=2&rft.spage=110&rft.isbn=&rft.btitle=&rft.title=Cancer+detection+and+prevention&rft.issn=0361090X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-31 N1 - Date created - 2007-05-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proteomics. 2004 Aug;4(8):2455-64 [15274140] Nutr Cancer. 2003;45(2):247-55 [12881020] Science. 1991 Jul 5;253(5015):49-53 [1905840] Cancer Res. 1993 Mar 15;53(6):1328-31 [8443813] Biochem Biophys Res Commun. 1994 Oct 28;204(2):578-84 [7980517] Eur J Cancer. 1994;30A(11):1675-82 [7833143] J Natl Cancer Inst. 1996 May 1;88(9):601-6 [8609661] Mol Cell Biol. 1996 Sep;16(9):4952-60 [8756654] Carcinogenesis. 1996 Nov;17(11):2367-75 [8968050] Nutr Cancer. 1997;27(1):31-40 [8970179] Nutr Cancer. 1997;28(3):236-47 [9343831] Leuk Res. 2003 Dec;27(12):1115-23 [12921950] Cancer Res. 2003 Oct 15;63(20):6607-12 [14583453] Cancer Res. 2003 Nov 15;63(22):7563-70 [14633667] Biochem Biophys Res Commun. 2004 Jan 16;313(3):654-65 [14697242] Oncogene. 2004 Feb 12;23(6):1308-13 [14647417] Oncogene. 2004 Feb 19;23(7):1405-11 [14661059] Pancreas. 2004 May;28(4):e90-5 [15097869] J Proteome Res. 2004 Mar-Apr;3(2):218-27 [15113097] Cancer Res. 1998 May 15;58(10):2196-9 [9605766] J Cell Physiol. 2005 Jan;202(1):295-303 [15316935] Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E92-105 [15367391] Int J Oncol. 2005 Jan;26(1):185-9 [15586239] Oncogene. 2005 Feb 17;24(8):1412-22 [15608671] Oncogene. 2005 Mar 3;24(10):1774-87 [15674352] Cancer Res. 2005 Jul 15;65(14):6042-53 [16024604] Oncogene. 2005 Aug 4;24(33):5246-51 [15897880] Carcinogenesis. 2005 Oct;26(10):1793-803 [15905199] Cancer Res. 2005 Oct 1;65(19):8861-8 [16204057] Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):7033-41 [16203797] Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15207-12 [16217026] Clin Cancer Res. 2005 Oct 15;11(20):7434-43 [16243817] Drug Metab Dispos. 2006 Feb;34(2):296-304 [16280456] Clin Cancer Res. 2006 Mar 1;12(5):1412-9 [16533763] Cancer Res. 2006 Apr 1;66(7):3347-50 [16585150] Anticancer Res. 2006 Mar-Apr;26(2A):1039-48 [16619504] J Mol Diagn. 2006 May;8(2):218-24 [16645208] Carcinogenesis. 2007 Jan;28(1):60-70 [16774933] Oncogene. 2007 Feb 8;26(6):934-44 [16862168] Oncogene. 2007 Feb 15;26(7):1003-12 [16909102] Cancer Lett. 2000 Aug 1;156(1):37-44 [10840157] Nature. 2000 Nov 16;408(6810):307-10 [11099028] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):781-3 [11158542] Clin Cancer Res. 2001 Feb;7(2):382-90 [11234894] Cancer Epidemiol Biomarkers Prev. 2001 May;10(5):483-8 [11352858] Cancer Res. 2002 Mar 1;62(5):1289-95 [11888893] Carcinogenesis. 2002 Sep;23(9):1491-6 [12189192] Cancer Res. 2002 Dec 1;62(23):6864-9 [12460900] Oncogene. 2003 Jan 23;22(3):445-50 [12545165] Cancer Genet Cytogenet. 2003 Jan 15;140(2):113-7 [12645648] Int J Oncol. 2004 Sep;25(3):661-70 [15289867] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Histone deacetylase inhibitors and demethylating agents: clinical development of histone deacetylase inhibitors for cancer therapy. AN - 70430329; 17464244 AB - The histone deacetylase inhibitors are a new class of agents that are currently in various stages of clinical development. Clinical trials have demonstrated activity, urging further investigation. At the same time, it has been discovered that these agents have their own challenges. In this review, we discuss clinical data gathered to date, combination therapies designed to increase efficacy, and toxicities attributed to this new class of agents. JF - Cancer journal (Sudbury, Mass.) AU - Piekarz, Richard L AU - Sackett, Dan L AU - Bates, Susan E AD - Molecular Therapeutic Section, Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1903, USA. rpiekarz@nih.gov PY - 2007 SP - 30 EP - 39 VL - 13 IS - 1 SN - 1528-9117, 1528-9117 KW - Antineoplastic Agents KW - 0 KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Histone Deacetylases KW - EC 3.5.1.98 KW - Index Medicus KW - Animals KW - Humans KW - Clinical Trials as Topic KW - Histone Deacetylases -- chemistry KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Enzyme Inhibitors -- adverse effects KW - Enzyme Inhibitors -- therapeutic use KW - Enzyme Inhibitors -- chemistry KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70430329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.atitle=Histone+deacetylase+inhibitors+and+demethylating+agents%3A+clinical+development+of+histone+deacetylase+inhibitors+for+cancer+therapy.&rft.au=Piekarz%2C+Richard+L%3BSackett%2C+Dan+L%3BBates%2C+Susan+E&rft.aulast=Piekarz&rft.aufirst=Richard&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Cancer+journal+%28Sudbury%2C+Mass.%29&rft.issn=15289117&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-22 N1 - Date created - 2007-04-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study. AN - 70409510; 17447857 AB - First line treatment of patients pts with poor-prognosis GCT, using BEP, is unsatisfactory. T-BEP (paclitaxel followed by BEP) demonstrated promising efficacy in the group of pts with intermediate and poor prognosis GCT. We present the results achieved with 1st line T-BEP in pts with poor-prognosis CGT. Twenty-four pts received T-BEP as initial therapy. Three pts (12.5%) had primary mediastinal GCT. Four cycles of T-BEP were given 21 days apart. Paclitaxel 175 mg/m2 was administered on day 1 before administration of BEP. The administration of G-CSF was not scheduled. Surgical resection of all radiographic residua was considered. All pts were assessable for response. Complete or partial response with negative tumor markers was achieved in 13 pts (54.2%; CI 95%: 34.3-74.1%). Median follow-up is 35.6 months. Median survival was not achieved and median time-to-progression is 9.5 months. Myelosuppression was the major toxicity with Gr3-4 granulocytopenia experienced in 52.1% of all courses. There were two treatment-related deaths due to sepsis. Patients treated with 1st line T-BEP didn't achieve higher response rate or time to progression. However, the overall survival observed in our study is surprisingly long. We do not recommend using this regimen without G-CSF support due to substantial toxicity. JF - Neoplasma AU - Mardiak, J AU - Sálek, T AU - Sycová-Milá, Z AU - Obertová, J AU - Recková, M AU - Mego, M AU - Hlavatá, Z AU - Brozmanová, K AU - Risnyovzská, Z AU - Svetlovská, D AU - Koza, I AD - National Cancer Institute, Bratislava, Slovakia. jozef.mardiak@nou.sk Y1 - 2007 PY - 2007 DA - 2007 SP - 240 EP - 245 VL - 54 IS - 3 SN - 0028-2685, 0028-2685 KW - Bleomycin KW - 11056-06-7 KW - Etoposide KW - 6PLQ3CP4P3 KW - Paclitaxel KW - P88XT4IS4D KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Paclitaxel -- administration & dosage KW - Neoplasm Staging KW - Bleomycin -- administration & dosage KW - Humans KW - Prognosis KW - Teratocarcinoma -- secondary KW - Cisplatin -- administration & dosage KW - Testicular Neoplasms -- drug therapy KW - Prospective Studies KW - Choriocarcinoma -- drug therapy KW - Etoposide -- administration & dosage KW - Carcinoma, Embryonal -- secondary KW - Adult KW - Teratocarcinoma -- drug therapy KW - Carcinoma, Embryonal -- drug therapy KW - Middle Aged KW - Choriocarcinoma -- secondary KW - Testicular Neoplasms -- secondary KW - Male KW - Neoplasms, Germ Cell and Embryonal -- pathology KW - Neoplasms, Germ Cell and Embryonal -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70409510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasma&rft.atitle=Paclitaxel%2C+bleomycin%2C+etoposide%2C+and+cisplatin+%28T-BEP%29+as+initial+treatment+in+patients+with+poor-prognosis+germ+cell+tumors+%28GCT%29%3A+a+phase+II+study.&rft.au=Mardiak%2C+J%3BS%C3%A1lek%2C+T%3BSycov%C3%A1-Mil%C3%A1%2C+Z%3BObertov%C3%A1%2C+J%3BReckov%C3%A1%2C+M%3BMego%2C+M%3BHlavat%C3%A1%2C+Z%3BBrozmanov%C3%A1%2C+K%3BRisnyovzsk%C3%A1%2C+Z%3BSvetlovsk%C3%A1%2C+D%3BKoza%2C+I&rft.aulast=Mardiak&rft.aufirst=J&rft.date=2007-01-01&rft.volume=54&rft.issue=3&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Neoplasma&rft.issn=00282685&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-28 N1 - Date created - 2007-04-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immuno-spin trapping analyses of DNA radicals. AN - 70347354; 17406615 AB - Immuno-spin trapping is a highly sensitive method for detecting DNA radicals in biological systems. This technique involves three main steps: (i) in situ and real-time trapping of DNA radicals with the nitrone spin trap 5,5-dimethyl-1-pyrroline-N-oxide (DMPO), thus forming DMPO-DNA nitrone adducts (referred to here as nitrone adducts); (ii) purification of nitrone adducts; and (iii) analysis of nitrone adducts by heterogeneous immunoassays using Abs against DMPO. In experiments, DMPO is added prior to the formation of free radicals. It diffuses easily through all cell compartments and is present when DNA free radicals are formed as a result of oxidative damage. Due to its low toxicity, DMPO can be used in cells at high enough concentrations to out-compete the normal reactions of DNA radicals, thus ensuring a high yield of DNA nitrone adducts. Because both protein and DNA nitrone adducts are formed, it is important that the DNA be pure in order to avoid misinterpretations. Depending on the model under study, this protocol can be completed in as few as 6 h. JF - Nature protocols AU - Ramirez, Dario C AU - Gomez-Mejiba, Sandra E AU - Mason, Ronald P AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Building 101, MD F0-02, Research Triangle Park, North Carolina 27709, USA. ramirez1@niehs.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 512 EP - 522 VL - 2 IS - 3 KW - Cyclic N-Oxides KW - 0 KW - DNA Adducts KW - Free Radicals KW - 5,5-dimethyl-1-pyrroline-1-oxide KW - 7170JZ1QF3 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Molecular Structure KW - DNA Adducts -- isolation & purification KW - Free Radicals -- isolation & purification KW - Cyclic N-Oxides -- metabolism KW - DNA Adducts -- metabolism KW - DNA -- isolation & purification KW - Immunoassay -- methods KW - DNA Damage KW - Spin Trapping -- methods KW - DNA -- metabolism KW - Spin Trapping -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70347354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+protocols&rft.atitle=Immuno-spin+trapping+analyses+of+DNA+radicals.&rft.au=Ramirez%2C+Dario+C%3BGomez-Mejiba%2C+Sandra+E%3BMason%2C+Ronald+P&rft.aulast=Ramirez&rft.aufirst=Dario&rft.date=2007-01-01&rft.volume=2&rft.issue=3&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=Nature+protocols&rft.issn=1750-2799&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-28 N1 - Date created - 2007-04-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Chem Res Toxicol. 2000 Oct;13(10):1056-64 [11080055] Free Radic Biol Med. 2003 Apr 15;34(8):1089-99 [12684094] Free Radic Biol Med. 2002 Aug 1;33(3):364-9 [12126758] Free Radic Biol Med. 2003 Jun 1;34(11):1473-81 [12757857] Arch Biochem Biophys. 2003 Jul 15;415(2):251-6 [12831849] FASEB J. 2003 Jul;17(10):1195-214 [12832285] Mutat Res. 2003 Oct 29;531(1-2):5-23 [14637244] Arch Biochem Biophys. 2004 Mar 1;423(1):57-65 [14989265] Free Radic Biol Med. 2004 May 15;36(10):1214-23 [15110386] Br J Pharmacol. 2004 May;142(2):231-55 [15155533] Nature. 1987 Dec 24-31;330(6150):773-4 [2827034] Science. 1988 Apr 29;240(4852):640-2 [2834821] Proc Natl Acad Sci U S A. 1990 Jun;87(12):4533-7 [2352934] Free Radic Res Commun. 1990;11(4-5):195-206 [1965722] Basic Life Sci. 1991;58:287-317; discussion 317-21 [1811474] Biochemistry. 1993 Oct 12;32(40):10599-606 [8399204] FEBS Lett. 1995 Oct 16;373(3):299-302 [7589487] Nature. 1996 Aug 22;382(6593):731-5 [8751447] J Biochem Biophys Methods. 1996 Jul 10;32(3):183-90 [8844325] Free Radic Biol Med. 1996;21(4):427-36 [8886792] FEBS Lett. 1997 Nov 24;418(1-2):73-5 [9414098] Mutat Res. 1999 Jul 16;428(1-2):17-22 [10517974] Trends Biochem Sci. 2005 Aug;30(8):453-61 [15996871] Nat Methods. 2006 Feb;3(2):123-7 [16432522] J Phys Chem B. 2005 Sep 8;109(35):16967-73 [16853159] Rapid Commun Mass Spectrom. 2006;20(15):2235-42 [16810703] Free Radic Biol Med. 2003 Apr 1;34(7):830-9 [12654471] Physiol Rev. 2002 Jan;82(1):47-95 [11773609] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. AN - 70314951; 17266762 AB - Cyclooxygenase (COX)-1 and COX-2 produce prostanoids from arachidonic acid and are thought to have important yet distinct roles in normal brain function. Deletion of COX-1 or COX-2 results in profound differences both in brain levels of prostaglandin E2 and in activation of the transcription factor nuclear factor-kappaB, suggesting that COX-1 and COX-2 play distinct roles in brain arachidonic acid metabolism and regulation of gene expression. To further elucidate the role of COX isoforms in the regulation of the brain transcriptome, microarray analysis of gene expression in the cerebral cortex and hippocampus of mice deficient in COX-1 (COX-1-/-) or COX-2 (COX-2-/-) was performed. A majority (>93%) of the differentially expressed genes in both the cortex and hippocampus were altered in one COX isoform knockout mouse but not the other. The major gene function affected in all genotype comparisons was 'transcriptional regulation'. Distinct biologic and metabolic pathways that were altered in COX-/- mice included beta oxidation, methionine metabolism, janus kinase signaling, and GABAergic neurotransmission. Our findings suggest that COX-1 and COX-2 differentially modulate brain gene expression. Because certain anti-inflammatory and analgesic treatments are based on inhibition of COX activity, the specific alterations observed in this study further our understanding of the relationship of COX-1 and COX-2 with signaling pathways in brain and of the therapeutic and toxicologic consequences of COX inhibition. JF - Genome biology AU - Toscano, Christopher D AU - Prabhu, Vinaykumar V AU - Langenbach, Robert AU - Becker, Kevin G AU - Bosetti, Francesca AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA. toscanoc@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1 VL - 8 IS - 1 KW - GABA Plasma Membrane Transport Proteins KW - 0 KW - Receptors, GABA KW - Methionine KW - AE28F7PNPL KW - Cyclooxygenase 1 KW - EC 1.14.99.1 KW - Cyclooxygenase 2 KW - Janus Kinases KW - EC 2.7.10.2 KW - Index Medicus KW - Animals KW - GABA Plasma Membrane Transport Proteins -- metabolism KW - Janus Kinases -- metabolism KW - Methionine -- metabolism KW - Up-Regulation -- genetics KW - Mice KW - Receptors, GABA -- genetics KW - Mice, Knockout KW - Genotype KW - Oxidation-Reduction KW - GABA Plasma Membrane Transport Proteins -- genetics KW - Receptors, GABA -- metabolism KW - Janus Kinases -- genetics KW - Gene Expression Profiling KW - Cyclooxygenase 2 -- deficiency KW - Cerebral Cortex -- enzymology KW - Hippocampus -- enzymology KW - Cyclooxygenase 1 -- deficiency KW - Gene Expression Regulation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70314951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Differential+gene+expression+patterns+in+cyclooxygenase-1+and+cyclooxygenase-2+deficient+mouse+brain.&rft.au=Toscano%2C+Christopher+D%3BPrabhu%2C+Vinaykumar+V%3BLangenbach%2C+Robert%3BBecker%2C+Kevin+G%3BBosetti%2C+Francesca&rft.aulast=Toscano&rft.aufirst=Christopher&rft.date=2007-01-01&rft.volume=8&rft.issue=1&rft.spage=R14&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-13 N1 - Date created - 2007-03-29 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Exp Cell Res. 2005 May 15;306(1):75-84 [15878334] Neuroscience. 1999;92(3):1061-77 [10426546] Brain Res Mol Brain Res. 2005 Oct 3;139(2):217-24 [16055227] FEBS J. 2005 Oct;272(19):4874-83 [16176262] J Clin Immunol. 2006 Jan;26(1):73-85 [16418805] J Neurochem. 2006 Feb;96(3):669-79 [16405503] J Immunol. 2006 Mar 15;176(6):3774-9 [16517747] Acta Neuropathol. 2006 Apr;111(4):351-63 [16456667] Brain Res Brain Res Protoc. 1999 Dec;4(3):341-50 [10592344] Ann N Y Acad Sci. 1999;889:52-61 [10668482] J Neurochem. 2000 Mar;74(3):1041-8 [10693935] Prostaglandins Other Lipid Mediat. 2004 Oct;74(1-4):1-10 [15560112] J Neurochem. 2004 Dec;91(6):1389-97 [15584915] J Neurochem. 2006 Aug;98(3):801-11 [16787416] Adv Exp Med Biol. 1999;466:133-43 [10709637] Anaesthesia. 2000 May;55(5):442-9 [10792135] Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8600-5 [10900018] Annu Rev Biochem. 2000;69:145-82 [10966456] J Neurosci. 2000 Sep 15;20(18):6920-6 [10995836] Inflamm Res. 2000 Aug;49(8):367-92 [11028754] Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9 [11158633] Cell Res. 2001 Mar;11(1):61-7 [11305326] Cell Biochem Biophys. 2000;33(2):101-25 [11325033] J Biol Chem. 2001 Jul 6;276(27):24918-24 [11337507] Methods. 2001 Dec;25(4):402-8 [11846609] J Mol Diagn. 2003 May;5(2):73-81 [12707371] Neuroreport. 2003 Oct 27;14(15):1927-9 [14561922] Prog Neuropsychopharmacol Biol Psychiatry. 2004 May;28(3):453-64 [15093951] J Neurochem. 1983 Sep;41(3):607-10 [6875555] FEBS Lett. 1989 Nov 6;257(2):377-9 [2479580] J Neurochem. 1994 Mar;62(3):1144-53 [8113801] J Biol Chem. 1995 May 5;270(18):10902-8 [7738031] Brain Res Mol Brain Res. 1996 Apr;37(1-2):309-16 [8738166] Brain Res Mol Brain Res. 1997 May;45(2):268-74 [9149101] Pharmacol Ther. 1997;73(3):265-80 [9175157] Annu Rev Immunol. 1998;16:293-322 [9597132] Biochem J. 1998 Aug 15;334 ( Pt 1):113-9 [9693110] Nat Med. 1998 Oct;4(10):1166-72 [9771750] Life Sci. 1999;64(24):2173-86 [10374907] Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):185-96 [16099403] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnic differences among adolescents seeking smoking cessation treatment: a structural analysis of responses on the Fagerström Test for Nicotine Dependence. AN - 70279172; 17365744 AB - Features of tobacco dependence vary by ethnicity, which could be partially due to measurement bias inherent in instruments that assess nicotine dependence. This study compared responses on the Fagerström Test for Nicotine Dependence (FTND) by African American adolescents (n = 478) with those of White adolescents (n = 661) seeking smoking cessation treatment. We conducted item-by-item comparisons by ethnicity for the six questions composing the FTND and confirmatory factor analyses and multiple indicators-multiple causes (MIMIC) modeling to test the hypothesis of measurement invariance of the FTND by ethnicity. Study participants (N = 1,139) were daily smokers of average age 15.4 years (SD = 1.3); 42.0% were African American and 61.5% female. White adolescents' pattern of responses to the FTND indicated a greater degree of dependence; these differences were statistically significant for five of the six items. The FTND exhibited a unidimensional structure with similar factor loadings in both White and African American adolescents. However, MIMIC modeling indicated differential reporting for three out of six items, suggesting that the FTND may not measure nicotine dependence equivalently for White and African American youth. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Schroeder, Jennifer R AU - Moolchan, Eric T AD - Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA. jschroed@intra.nida.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 137 EP - 145 VL - 9 IS - 1 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Demography KW - Factor Analysis, Statistical KW - Humans KW - Surveys and Questionnaires KW - Adolescent KW - Male KW - Female KW - Patient Acceptance of Health Care -- statistics & numerical data KW - Smoking Cessation -- methods KW - Tobacco Use Disorder -- ethnology KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- ethnology KW - Smoking -- prevention & control KW - Tobacco Use Disorder -- diagnosis KW - Ethnic Groups -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70279172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Ethnic+differences+among+adolescents+seeking+smoking+cessation+treatment%3A+a+structural+analysis+of+responses+on+the+Fagerstr%C3%B6m+Test+for+Nicotine+Dependence.&rft.au=Schroeder%2C+Jennifer+R%3BMoolchan%2C+Eric+T&rft.aulast=Schroeder&rft.aufirst=Jennifer&rft.date=2007-01-01&rft.volume=9&rft.issue=1&rft.spage=137&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-08 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nicotine, cotinine, withdrawal, and craving patterns during smoking and nicotine nasal spray use: results from a pilot study with African American men. AN - 70276439; 17365738 AB - Nicotine intake via smoking is highly variable. Individualized dosing of nicotine replacement therapy (NRT) may improve product efficacy, but a better understanding of the within-day and within-subject relationships between smoking, NRT use, nicotine and cotinine concentrations in blood, and cravings and withdrawal symptoms is needed to inform dosing algorithms. A pilot study was undertaken to collect data on these relationships and to assess the feasibility of the methods needed for this type of research, including a sophisticated statistical modeling technique (a two-part mixed-effects model with correlated random effects that accounts for clumping at zero). Because nicotine metabolism varies by gender and race, the sample was homogeneous with respect to these characteristics. In a within-subjects study, 27 African American adult male smokers carried a computerized cigarette dispenser for 1 week, capturing the time each cigarette was smoked. Subjects then entered an inpatient setting for 1 day of scheduled smoking (matched to data from the cigarette dispenser to create an ecologically valid schedule) and 4 days of ad libitum nicotine nasal spray use, while tobacco abstinent. Eight times per day, at 2-hour intervals, blood was drawn and ratings of cigarette cravings and withdrawal symptoms were obtained. On average, subjects used less than half of the manufacturer's recommended minimum daily dose of nicotine nasal spray. Large differences in nicotine and cotinine levels were observed between individuals. When predicting nicotine, cotinine, withdrawal, and cravings, we observed significant interactions between route of nicotine intake and a variety of independent variables. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Mabry, Patricia L AU - Tooze, Janet A AU - Moser, Richard P AU - Augustson, Erik M AU - Malcolm, Robert J AU - Benowitz, Neal L AD - SAIC-Frederick, Inc., support to Tobacco Control Research Branch (TCRB), Behavioral Research Program (BRP), Division of Cancer Control and Population Sciences (DCCPS), National Cancer Institute. Bethesda, MD. mabryp@od.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 65 EP - 82 VL - 9 IS - 1 SN - 1462-2203, 1462-2203 KW - Ganglionic Stimulants KW - 0 KW - Nicotine KW - 6M3C89ZY6R KW - Cotinine KW - K5161X06LL KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Administration, Intranasal KW - Adult KW - Smoking Cessation -- methods KW - Algorithms KW - Pilot Projects KW - Male KW - Nicotine -- therapeutic use KW - Tobacco Use Disorder -- blood KW - African Americans -- statistics & numerical data KW - Nicotine -- adverse effects KW - Cotinine -- blood KW - Ganglionic Stimulants -- therapeutic use KW - Tobacco Use Disorder -- ethnology KW - Nicotine -- administration & dosage KW - Smoking -- prevention & control KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Substance Withdrawal Syndrome -- etiology KW - Ganglionic Stimulants -- adverse effects KW - Substance Withdrawal Syndrome -- epidemiology KW - Tobacco Use Disorder -- prevention & control KW - Smoking -- ethnology KW - Ganglionic Stimulants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70276439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=Nicotine%2C+cotinine%2C+withdrawal%2C+and+craving+patterns+during+smoking+and+nicotine+nasal+spray+use%3A+results+from+a+pilot+study+with+African+American+men.&rft.au=Mabry%2C+Patricia+L%3BTooze%2C+Janet+A%3BMoser%2C+Richard+P%3BAugustson%2C+Erik+M%3BMalcolm%2C+Robert+J%3BBenowitz%2C+Neal+L&rft.aulast=Mabry&rft.aufirst=Patricia&rft.date=2007-01-01&rft.volume=9&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-08 N1 - Date created - 2007-03-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The new EPA regulations for protecting human subjects: haste makes waste. AN - 70248237; 17348257 JF - The Hastings Center report AU - Resnik, David B AD - National Institute of Health Sciences, National Institutes of Health, USA. PY - 2007 SP - 17 EP - 21 VL - 37 IS - 1 SN - 0093-0334, 0093-0334 KW - Environmental Pollutants KW - 0 KW - Pesticides KW - Bioethics KW - Index Medicus KW - United States KW - Government Regulation KW - Humans KW - United States Dept. of Health and Human Services KW - Chemical Industry KW - Advisory Committees KW - Research Subjects -- legislation & jurisprudence KW - United States Environmental Protection Agency KW - Environmental Exposure -- adverse effects KW - Decision Making KW - Food -- standards KW - Pesticides -- adverse effects KW - Environmental Pollutants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70248237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Hastings+Center+report&rft.atitle=The+new+EPA+regulations+for+protecting+human+subjects%3A+haste+makes+waste.&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2007-01-01&rft.volume=37&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=The+Hastings+Center+report&rft.issn=00930334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-30 N1 - Date created - 2007-03-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Science. 2005 Jul 8;309(5732):232 [16002591] Account Res. 2005 Apr-Jun;12(2):69-101 [16220621] Environ Health Perspect. 2005 Jul;113(7):813-7 [16002367] Environ Health Perspect. 2004 Jun;112(8):914-9 [15175182] Kennedy Inst Ethics J. 1997 Sep;7(3):291-8 [11660360] Am J Public Health. 2004 Nov;94(11):1908-16 [15514226] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Imaging techniques for small animal imaging models of pulmonary disease: micro-CT. AN - 70225062; 17325973 AB - Microcomputed tomography (micro-CT) is ideal for quantifying pulmonary disease because of the inherent contrast between tissue and air that exists in the lungs. Both in vivo and in vitro studies can be performed using micro-CT. Live animal studies show function, while fixed specimen studies show structure. Through the use of image processing techniques, both acute and chronic lung diseases can be quantified. The information provided by micro-CT is complementary to histological evaluation, since CT is nondestructive. This paper discusses two examples, in vivo and in vitro, of how micro-CT can be used to assess pulmonary diseases in small animal models. With the use of micro-CT, we were able to quantify pulmonary fibrosis in the live rat and investigate the microstructure of the airway in fixed mouse lungs. JF - Toxicologic pathology AU - Johnson, Kennita A AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. johnso58@niehs.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 59 EP - 64 VL - 35 IS - 1 SN - 0192-6233, 0192-6233 KW - Antibiotics, Antineoplastic KW - 0 KW - Bleomycin KW - 11056-06-7 KW - Index Medicus KW - Acute Disease KW - Animals KW - Microcomputers KW - Gene Silencing KW - Bleomycin -- toxicity KW - Mice KW - Antibiotics, Antineoplastic -- toxicity KW - Mice, Knockout KW - Rats KW - Bronchi -- anatomy & histology KW - Imaging, Three-Dimensional KW - Rats, Inbred F344 KW - Mice, Inbred C57BL KW - Chronic Disease KW - Female KW - Male KW - Bronchography KW - Tomography, X-Ray Computed -- methods KW - Lung -- diagnostic imaging KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- diagnostic imaging KW - Pulmonary Fibrosis -- chemically induced KW - Lung -- drug effects KW - Disease Models, Animal KW - Lung -- pathology KW - Image Processing, Computer-Assisted UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70225062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Imaging+techniques+for+small+animal+imaging+models+of+pulmonary+disease%3A+micro-CT.&rft.au=Johnson%2C+Kennita+A&rft.aulast=Johnson&rft.aufirst=Kennita&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=59&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Cell Biochem Suppl. 2002;39:116-24 [12552611] J Biomech. 2003 Nov;36(11):1587-94 [14522199] Acad Radiol. 2003 Oct;10(10):1104-18 [14587629] Med Phys. 2003 Nov;30(11):2869-77 [14655933] Phys Med Biol. 2005 Apr 7;50(7):1405-19 [15798332] Mol Imaging. 2004 Jan;3(1):55-62 [15142412] Phys Med Biol. 2004 Sep 7;49(17):4163-72 [15470930] Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1571-7 [9817710] Med Phys. 2004 Dec;31(12):3324-9 [15651615] Am J Respir Cell Mol Biol. 2004 Feb;30(2):129-38 [14729505] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Overview of the molecular carcinogenesis of mouse lung tumor models of human lung cancer. AN - 70223398; 17325975 AB - Lung cancer is the leading cause of cancer death worldwide, and the need to develop better diagnostic techniques and therapies is urgent. Mouse models have been utilized for studying carcinogenesis of human lung cancers, and many of the major genetic alterations detected in human lung cancers have also been identified in mouse lung tumors. The importance of mouse models for understanding human lung carcinogenic processes and in developing early diagnostic techniques, preventive measures and therapies cannot be overstated. In this report, the major known molecular alterations in lung tumorigenesis of mice are reviewed and compared to those in humans. JF - Toxicologic pathology AU - Wakamatsu, Nobuko AU - Devereux, Theodora R AU - Hong, Hue-Hua L AU - Sills, Robert C AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 75 EP - 80 VL - 35 IS - 1 SN - 0192-6233, 0192-6233 KW - Tumor Suppressor Protein p53 KW - 0 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Genes, ras -- genetics KW - Humans KW - Mice KW - Tumor Suppressor Protein p53 -- genetics KW - Species Specificity KW - Mutation KW - Early Diagnosis KW - Adenocarcinoma -- diagnosis KW - Lung Neoplasms -- diagnosis KW - Lung Neoplasms -- genetics KW - Disease Models, Animal KW - Adenocarcinoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70223398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=Overview+of+the+molecular+carcinogenesis+of+mouse+lung+tumor+models+of+human+lung+cancer.&rft.au=Wakamatsu%2C+Nobuko%3BDevereux%2C+Theodora+R%3BHong%2C+Hue-Hua+L%3BSills%2C+Robert+C&rft.aulast=Wakamatsu&rft.aufirst=Nobuko&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2006 Feb 15;66(4):1956-63 [16488994] Oncogene. 2006 Feb 23;25(8):1277-80 [16247444] J Natl Cancer Inst. 2000 Sep 20;92(18):1511-6 [10995806] Exp Lung Res. 2000 Dec;26(8):709-30 [11195466] Exp Lung Res. 2000 Dec;26(8):731-42 [11195467] Nat Cell Biol. 2001 Jan;3(1):1-7 [11146619] Exp Lung Res. 2001 Apr-May;27(3):319-30 [11293331] Oncogene. 2001 Mar 29;20(14):1765-70 [11313923] Carcinogenesis. 2001 May;22(5):751-6 [11323394] Nature. 2001 Apr 26;410(6832):1111-6 [11323676] Nat Genet. 2001 Sep;29(1):25-33 [11528387] Genes Dev. 2001 Dec 15;15(24):3249-62 [11751631] Cancer Res. 2002 Jun 1;62(11):3244-50 [12036940] Carcinogenesis. 2002 Oct;23(10):1737-43 [12376484] Oncogene. 2002 Oct 21;21(48):7421-34 [12379883] Natl Toxicol Program Tech Rep Ser. 2002 Dec;(507):1-343 [12533744] Carcinogenesis. 2003 Jan;24(1):121-32 [12538357] Neoplasia. 2003 Jul-Aug;5(4):362-6 [14511407] Cancer Cell. 2003 Sep;4(3):181-9 [14522252] Oncogene. 2004 Feb 5;23(5):1166-76 [14647414] Cancer Res. 2004 Mar 1;64(5):1647-54 [14996723] Cancer Res. 2004 Apr 1;64(7):2307-16 [15059877] Cancer Res. 2004 Jun 1;64(11):3844-8 [15172992] Oncogene. 2004 Oct 7;23(46):7746-52 [15361829] Br J Cancer. 2006 Jul 17;95(2):139-45 [16786043] Environ Mol Mutagen. 2007 Apr-May;48(3-4):299-306 [16395694] Carcinogenesis. 1996 Aug;17(8):1735-40 [8761434] Mol Carcinog. 1996 Dec;17(4):217-23 [8989915] J Pathol. 1997 Apr;181(4):401-4 [9196437] Crit Rev Toxicol. 1997 Jul;27(4):319-65 [9263643] Cancer Res. 1998 Sep 1;58(17):3761-4 [9731479] Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11891-6 [9751761] Clin Cancer Res. 1996 Jul;2(7):1169-76 [9816284] Hematol Oncol Clin North Am. 1998 Oct;12(5):1037-53 [9888020] Carcinogenesis. 2000 Apr;21(4):543-50 [10753183] Carcinogenesis. 2000 Jul;21(7):1371-7 [10874016] Carcinogenesis. 2000 Sep;21(9):1691-700 [10964101] J Natl Cancer Inst. 1971 Sep;47(3):697-701 [5157586] Toxicology. 1989 Mar;54(3):241-71 [2650016] Proc Natl Acad Sci U S A. 1989 May;86(9):3070-4 [2654935] Science. 1989 Oct 27;246(4929):491-4 [2554494] Am J Pathol. 1991 Aug;139(2):413-22 [1651059] Environ Health Perspect. 1991 Jun;93:145-8 [1773785] Cancer Res. 1992 Jun 1;52(11):3164-73 [1591728] Cancer Res. 1992 Jul 15;52(14):3875-9 [1617663] Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5804-8 [1352876] Prog Clin Biol Res. 1992;376:303-20 [1528924] Carcinogenesis. 1993 May;14(5):803-10 [8504472] Carcinogenesis. 1993 May;14(5):819-26 [8504473] Epidemiology. 1994 Mar;5(2):138-46 [8172988] Cancer Res. 1994 Dec 1;54(23):6257-64 [7954475] Carcinogenesis. 1995 May;16(5):1065-9 [7767966] Carcinogenesis. 1995 Jul;16(7):1623-8 [7614698] Carcinogenesis. 1999 Apr;20(4):657-62 [10223196] IARC Sci Publ. 1999;(146):55-86 [10353384] Cancer Res. 1999 Aug 1;59(15):3634-40 [10446974] J Natl Cancer Inst. 1951 Jun;11(6):1187-1221 [14861648] Nat Genet. 2005 Jan;37(1):48-55 [15608639] Cancer Res. 2005 Jan 1;65(1):92-8 [15665283] Nat Rev Mol Cell Biol. 2005 Jan;6(1):44-55 [15688066] Oncogene. 2005 Mar 10;24(11):1958-63 [15688036] Genes Dev. 2005 Mar 15;19(6):643-64 [15769940] Cancer Res. 2005 Jun 15;65(12):5076-83 [15958551] Carcinogenesis. 2005 Sep;26(9):1481-7 [15661809] Carcinogenesis. 2005 Nov;26(11):1999-2009 [15944214] Cancer Res. 2005 Nov 15;65(22):10280-8 [16288016] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse. AN - 70219074; 17325976 AB - Ethylene oxide is a multisite carcinogen in rodents and classified as a human carcinogen by the National Toxicology Program. In 2-year mouse studies, ethylene oxide (EO) induced lung, Harderian gland (HG), and uterine neoplasms. We evaluated representative EO-induced and equivalent spontaneous neoplasms for K-ras mutations in codons 12, 13, and 61. K-ras mutations were identified in 100% (23/23) of the EO-induced lung neoplasms and 25% (27/108) of the spontaneous lung neoplasms. Codon 12 G to T transversions were common in EO-induced lung neoplasms (21/23) but infrequent in spontaneous lung neoplasms (1/108). K-ras mutations were found in 86% (18/21) of the EO-induced HG neoplasms and 7% (2/27) of the spontaneous HG neoplasms. Codon 13 G to C and codon 12 G to T transversions were predominant in the EO-induced HG neoplasms but absent in spontaneous HG neoplasms (0/27). K-ras mutations occurred in 83% (5/6) of the EO-induced uterine carcinomas and all were codon 13 C to T transitions. These data show a strong predilection for development of K-ras mutations in EO-induced lung, Harderian gland, and uterine neoplasms. This suggests that EO specifically targets the K-ras gene in multiple tissue types and that this event is a critical component of EO-induced tumorigenesis. JF - Toxicologic pathology AU - Hong, Hue-Hua L AU - Houle, Christopher D AU - Ton, Thai-Vu T AU - Sills, Robert C AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA. hong5@niehs.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 81 EP - 85 VL - 35 IS - 1 SN - 0192-6233, 0192-6233 KW - Carcinogens KW - 0 KW - DNA, Neoplasm KW - Disinfectants KW - Ethylene Oxide KW - JJH7GNN18P KW - Index Medicus KW - Mice, Inbred Strains KW - Animals KW - Harderian Gland -- pathology KW - Dose-Response Relationship, Drug KW - Inhalation Exposure KW - Mice KW - DNA, Neoplasm -- analysis KW - Harderian Gland -- drug effects KW - Mutation KW - Disinfectants -- toxicity KW - Male KW - Female KW - Uterine Neoplasms -- genetics KW - Adenocarcinoma -- chemically induced KW - Uterine Neoplasms -- chemically induced KW - Carcinogens -- toxicity KW - Adenocarcinoma -- genetics KW - Uterine Neoplasms -- pathology KW - Adenocarcinoma -- pathology KW - Genes, ras KW - Adenoma -- chemically induced KW - Lung Neoplasms -- genetics KW - Sebaceous Gland Neoplasms -- pathology KW - Lung Neoplasms -- chemically induced KW - Sebaceous Gland Neoplasms -- genetics KW - Adenoma -- genetics KW - Adenoma -- pathology KW - Sebaceous Gland Neoplasms -- chemically induced KW - Ethylene Oxide -- toxicity KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70219074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicologic+pathology&rft.atitle=K-ras+mutations+in+lung+tumors+and+tumors+from+other+organs+are+consistent+with+a+common+mechanism+of+ethylene+oxide+tumorigenesis+in+the+B6C3F1+mouse.&rft.au=Hong%2C+Hue-Hua+L%3BHoule%2C+Christopher+D%3BTon%2C+Thai-Vu+T%3BSills%2C+Robert+C&rft.aulast=Hong&rft.aufirst=Hue-Hua&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Toxicologic+pathology&rft.issn=01926233&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Carcinogenesis. 1991 Feb;12(2):299-303 [1995195] N Engl J Med. 1991 May 16;324(20):1402-7 [2020295] Mutat Res. 1991 Sep-Oct;250(1-2):483-97 [1719390] Mutat Res. 1992 Jan;281(1):31-7 [1371589] Cancer Res. 1992 Aug 15;52(16):4328-34 [1643630] Chem Biol Interact. 1992 Jun 15;83(1):35-54 [1643667] Carcinogenesis. 1993 May;14(5):795-801 [8504471] Mutat Res. 1994 Jan 16;304(2):229-34 [7506366] Br J Ind Med. 1993 Nov;50(11):971-97 [8280635] Carcinogenesis. 1994 Nov;15(11):2665-7 [7955123] Environ Mol Mutagen. 1994;24(3):161-7 [7957119] IARC Monogr Eval Carcinog Risks Hum. 1994;60:1-560 [7869568] Cancer Lett. 1995 Jun 8;92(2):223-7 [7600534] Carcinogenesis. 1995 Jul;16(7):1623-8 [7614698] Jpn J Cancer Res. 1995 Sep;86(9):802-10 [7591956] Toxicol Appl Pharmacol. 1996 Jan;136(1):8-19 [8560484] Carcinogenesis. 1997 Apr;18(4):783-9 [9111215] Mutat Res. 1997 Jul 14;391(3):153-64 [9268040] Br J Cancer. 1998 Mar;77(5):720-3 [9514049] Eur J Cancer Prev. 1998 Apr;7(2):167-8 [9818781] Carcinogenesis. 1999 Apr;20(4):657-62 [10223196] Carcinogenesis. 1999 Sep;20(9):1787-92 [10469625] Mutat Res. 1999 Dec 17;431(2):397-415 [10636004] Mutat Res. 2000 Jan 17;447(1):27-48 [10686305] Carcinogenesis. 2000 Sep;21(9):1661-9 [10964097] Cancer Lett. 2001 Mar 26;164(2):207-12 [11179836] Mutat Res. 2001 May 31;492(1-2):59-67 [11377244] Toxicol Pathol. 2001 Jul-Aug;29(4):422-9 [11560247] Ann N Y Acad Sci. 2002 Dec;982:177-89 [12562636] Mutagenesis. 2004 May;19(3):215-22 [15123787] Pharmacol Rev. 1966 Mar;18(1):805-38 [5325210] Carcinogenesis. 1990 Feb;11(2):307-12 [2302758] Mol Carcinog. 1990;3(5):287-95 [2244961] Int J Oncol. 2005 May;26(5):1241-55 [15809715] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uncertainties in individual doses in a case-control study of thyroid cancer after the Chernobyl accident. AN - 70153848; 17634207 AB - Individual radiation doses to the thyroid were reconstructed for 2239 subjects of a case-control study of thyroid cancer among young people that was carried out in regions of Belarus and Russia contaminated by radioactive fallout from the Chernobyl accident. Although the process of dose reconstruction provides a point estimate of each subject's dose, it is obvious that there is uncertainty associated with these dose calculations. The following main sources of uncertainty in the estimated individual doses were identified: (1) shared and unshared errors associated with parameters of the dosimetry model; and (2) unshared errors that are associated with the variability, reliability and ability of information from the personal interviews. Besides setting up proper distributions for the parameters of the dosimetry model, inter-individual correlations were also defined to take into account shared errors. By the application of Monte Carlo simulations, a set of approximately log-normally distributed thyroid doses was obtained for each subject; the geometric standard deviations of the distributions are found to vary among individuals from 1.7 to 3.7. JF - Radiation protection dosimetry AU - Drozdovitch, V AU - Maceika, E AU - Khrouch, V AU - Zvonova, I AU - Vlasov, O AU - Bouville, A AU - Cardis, E AD - International Agency for Research on Cancer, 150 cours Albert-Thomas, 69372 Lyon Cedex 08, France. drozdovv@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 540 EP - 543 VL - 127 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Reproducibility of Results KW - Risk Factors KW - Humans KW - Body Burden KW - Case-Control Studies KW - Incidence KW - Data Interpretation, Statistical KW - Thyroid Neoplasms -- epidemiology KW - Chernobyl Nuclear Accident KW - Neoplasms, Radiation-Induced -- epidemiology KW - Risk Assessment -- methods KW - Radiation Monitoring -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70153848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Uncertainties+in+individual+doses+in+a+case-control+study+of+thyroid+cancer+after+the+Chernobyl+accident.&rft.au=Drozdovitch%2C+V%3BMaceika%2C+E%3BKhrouch%2C+V%3BZvonova%2C+I%3BVlasov%2C+O%3BBouville%2C+A%3BCardis%2C+E&rft.aulast=Drozdovitch&rft.aufirst=V&rft.date=2007-01-01&rft.volume=127&rft.issue=1-4&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Harmonization of internal dosimetry procedures in Latin America--ARCAL/IAEA project. AN - 70134617; 17569691 AB - Under the auspices of the Regional Coordination Agreement for Latin America, representatives of the eight member states have participated in a project to improve radiological protection for workers exposed to unsealed sources of radiation. The design of the project was based on information obtained from a questionnaire circulated among the participants, from which the initial status of internal dosimetry services in each country was characterised. The objective of the project is to harmonize internal dosimetry procedures, with reference to International Atomic Energy Agency recommendations. After the implementation of new procedures and personnel training, four intercomparison exercises were carried out: measurement of iodine in thyroid phantoms, measurement of gamma emitters in urine samples, measurement of beta emitters in urine samples and internal dose assessments. This project has resulted in important improvements in internal dosimetry services in the region. JF - Radiation protection dosimetry AU - Melo, D AU - Suarez, R Cruz AU - Rojo, A AU - Dantas, B M AU - Julião, L AU - Serdero, N AU - Videla, R AU - Puerta, J A AU - Lopez, G AU - Alfaro, M M AU - Gonzáles, S AU - Hermida, J C AU - Navarro, T AD - Instituto de Radioproteção e Dosimetria - Av. Salvador Allende S/N, Recreio dos Bandeirantes, RJ 22780-160, Brazil. melodun@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 325 EP - 328 VL - 127 IS - 1-4 SN - 0144-8420, 0144-8420 KW - Index Medicus KW - Radiation Dosage KW - Latin America KW - Biological Assay -- methods KW - Radiation Protection -- methods KW - Safety Management -- methods KW - Interinstitutional Relations KW - Radiometry -- methods KW - Safety Management -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70134617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+protection+dosimetry&rft.atitle=Harmonization+of+internal+dosimetry+procedures+in+Latin+America--ARCAL%2FIAEA+project.&rft.au=Melo%2C+D%3BSuarez%2C+R+Cruz%3BRojo%2C+A%3BDantas%2C+B+M%3BJuli%C3%A3o%2C+L%3BSerdero%2C+N%3BVidela%2C+R%3BPuerta%2C+J+A%3BLopez%2C+G%3BAlfaro%2C+M+M%3BGonz%C3%A1les%2C+S%3BHermida%2C+J+C%3BNavarro%2C+T&rft.aulast=Melo&rft.aufirst=D&rft.date=2007-01-01&rft.volume=127&rft.issue=1-4&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Radiation+protection+dosimetry&rft.issn=01448420&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-08-19 N1 - Date created - 2008-05-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rural populations are not protected from drug use and abuse. AN - 70080549; 18237317 JF - The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association AU - Thomas, Yonette F AU - Compton, Wilson M AU - National Institute on Drug Abuse, National Institutes of Health AD - Epidemiology Research Branch, Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9589, USA. ythomas@mail.nih.gov ; National Institute on Drug Abuse, National Institutes of Health Y1 - 2007 PY - 2007 DA - 2007 SP - 1 EP - 3 VL - 23 Suppl SN - 0890-765X, 0890-765X KW - Index Medicus KW - Humans KW - United States -- epidemiology KW - Rural Population KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70080549?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+rural+health+%3A+official+journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.atitle=Rural+populations+are+not+protected+from+drug+use+and+abuse.&rft.au=Thomas%2C+Yonette+F%3BCompton%2C+Wilson+M%3BNational+Institute+on+Drug+Abuse%2C+National+Institutes+of+Health&rft.aulast=Thomas&rft.aufirst=Yonette&rft.date=2007-01-01&rft.volume=23+Suppl&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+rural+health+%3A+official+journal+of+the+American+Rural+Health+Association+and+the+National+Rural+Health+Care+Association&rft.issn=0890765X&rft_id=info:doi/10.1111%2Fj.1748-0361.2007.00116.x LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-27 N1 - Date created - 2008-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1111/j.1748-0361.2007.00116.x ER - TY - JOUR T1 - Gene expression signatures of interleukin-2 in vivo and in vitro and their relation to anticancer therapy. AN - 70075066; 18197806 AB - Treatment with human recombinant interleukin-2 (rIL-2) can successfully eradicate advanced cancer in humans; however, its utilization is limited by the unpredictability of its effectiveness and the excessive toxicity often associated with its use. The mechanisms responsible for immune-mediated tumor regression and those associated with limiting toxicity have not yet been sorted out. Thus, this review critically addresses what has been done in the past to understand this biologically and practically important question and discusses future strategies to enhance the understanding of this interesting model of immune-mediated tumor rejection. In particular, the first aim of this review is to discuss what is known about the mechanism(s) responsible for tumor rejection; the second aim is to review the relationship between the toxicity induced by rIL-2 treatment and its effectiveness; the third aim is to summarize novel insights into the possible mechanism of rIL-2 activity in vivo using high-throughput strategies aimed at the global assessment in real-time of events associated with rIL-2 therapy in humans. This information will not only lead to a better utilization of this biological agent in clinical practice but it may also provide important information about how immune-mediated tissue rejection occurs. JF - Critical reviews in immunology AU - Jin, Ping AU - Wang, Ena AU - Provenzano, Maurizio AU - Stroncek, David AU - Marincola, Francesco M AD - Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 437 EP - 448 VL - 27 IS - 5 SN - 1040-8401, 1040-8401 KW - Antineoplastic Agents KW - 0 KW - Cytokines KW - Interleukin-2 KW - Receptors, Interleukin-2 KW - Recombinant Proteins KW - Index Medicus KW - Humans KW - Immunotherapy KW - Antineoplastic Agents -- metabolism KW - Cytokines -- immunology KW - Gene Expression KW - Cytokines -- metabolism KW - Receptors, Interleukin-2 -- immunology KW - Antineoplastic Agents -- adverse effects KW - Antineoplastic Agents -- immunology KW - Receptors, Interleukin-2 -- metabolism KW - Recombinant Proteins -- immunology KW - Recombinant Proteins -- adverse effects KW - Antineoplastic Agents -- therapeutic use KW - Recombinant Proteins -- therapeutic use KW - Recombinant Proteins -- administration & dosage KW - T-Lymphocyte Subsets -- metabolism KW - Neoplasms -- drug therapy KW - Interleukin-2 -- adverse effects KW - Interleukin-2 -- administration & dosage KW - Interleukin-2 -- therapeutic use KW - T-Lymphocyte Subsets -- immunology KW - Interleukin-2 -- immunology KW - Neoplasms -- genetics KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70075066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+immunology&rft.atitle=Gene+expression+signatures+of+interleukin-2+in+vivo+and+in+vitro+and+their+relation+to+anticancer+therapy.&rft.au=Jin%2C+Ping%3BWang%2C+Ena%3BProvenzano%2C+Maurizio%3BStroncek%2C+David%3BMarincola%2C+Francesco+M&rft.aulast=Jin&rft.aufirst=Ping&rft.date=2007-01-01&rft.volume=27&rft.issue=5&rft.spage=437&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+immunology&rft.issn=10408401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-02-14 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical significance of metabolic superscan in patients with hyperthyroidism. AN - 70065608; 18228210 AB - Hyperthyroid patients commonly complain of generalized bony aches, which are frequently overlooked due to the more prominent symptoms of cardiovascular and nervous disturbances. Hyperthyroid patients are expected to have abnormal bone metabolism as part of the generalized hypermetabolic status. The aim of this study is to verify the presence of metabolic bone superscan in association with the hypermetabolic stats in various groups of hyperthyroidism. Secondly, to correlate these superscan features with the various laboratory results in hyperthyroid patients. Forty-five hyperthyroid patients confirmed by clinical and laboratory results were enrolled in this work. In all patients, a (99m)Tc-pertechnetate thyroid uptake scan was acquired. On a different day, total body bone scan was acquired three hours post IV injection of 555-925 MBq of (99m)Tc-MDP. Serum FT3, FT4, TSH, Ca++, alkaline phosphatase (AP) and parathyroid hormone (PTH) were monitored in all patients as markers of thyroid and bone metabolism. Ten cases with no thyroid diseases were included as a control group. Patients with thyroiditis or long history of antithyroid drugs for more than one year were excluded from the study. The patients were subdivided into three groups: Graves disease (GD) (n = 30), toxic nodular goiter (TNG) (n = 10) and autonomous toxic adenoma (AT) (n = 5). The TSH for the whole group was significantly suppressed compared to the control group with higher suppression in the Graves disease group than in the TNG or AT groups. (99m)Tc-pertechnetate uptake values in the Graves disease group were significantly higher than the TNG and AT groups (p 0.05). Disturbances in bone metabolism are more prevalent in Graves disease than in other types of hyperthyroidism. The addition of the bone scan to the diagnostic work up of patients with Graves disease is a sensitive indicator for metabolic bone changes and could help in the future management and follow up for this group of patients. JF - Nuclear medicine review. Central & Eastern Europe AU - Kotb, Magdy H AU - El-Maghraby, Tarek AU - Khalafallah, Khaled AU - Omar, Walid AU - Grace, Bahaa Demian AU - Al-Nahhas, Adil AD - Nuclear Medicine, National Cancer Institute, Cairo University, Egypt. Y1 - 2007 PY - 2007 DA - 2007 SP - 76 EP - 81 VL - 10 IS - 2 SN - 1506-9680, 1506-9680 KW - Radiopharmaceuticals KW - 0 KW - Sodium Pertechnetate Tc 99m KW - A0730CX801 KW - Technetium Tc 99m Medronate KW - X89XV46R07 KW - Index Medicus KW - Sensitivity and Specificity KW - Reproducibility of Results KW - Humans KW - Adult KW - Male KW - Female KW - Radionuclide Imaging KW - Bone Diseases, Metabolic -- diagnostic imaging KW - Hyperthyroidism -- diagnostic imaging KW - Bone Diseases, Metabolic -- complications KW - Hyperthyroidism -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70065608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+medicine+review.+Central+%26+Eastern+Europe&rft.atitle=Clinical+significance+of+metabolic+superscan+in+patients+with+hyperthyroidism.&rft.au=Kotb%2C+Magdy+H%3BEl-Maghraby%2C+Tarek%3BKhalafallah%2C+Khaled%3BOmar%2C+Walid%3BGrace%2C+Bahaa+Demian%3BAl-Nahhas%2C+Adil&rft.aulast=Kotb&rft.aufirst=Magdy&rft.date=2007-01-01&rft.volume=10&rft.issue=2&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Nuclear+medicine+review.+Central+%26+Eastern+Europe&rft.issn=15069680&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-14 N1 - Date created - 2008-01-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vitro mitigation of arsenic toxicity by tea polyphenols in human lymphocytes. AN - 70064155; 18197836 AB - The groundwater arsenicals have brought dreadful misery for the people residing in the endemic regions of West Bengal, India. Arsenic-related anomalies include arsenicosis, hyperkera-tosis, gastric complications, liver fibrosis, peripheral neuropathy, and cancer. Some of these diseases have been frequently associated with overproduction of reactive oxygen species that cause DNA damage and improper functioning of body's antioxidant defense mechanism. Natural polyphenols present in tea serve as excellent antioxidants. In the present study, an attempt has been made to elucidate the role of representative polyphenols and extracts of green and black tea in modulating sodium arsenite (As III)-induced DNA damage in normal human lymphocytes. Comet assay was used to detect the DNA damage. Arsenic-induced oxidative stress was measured with generation of reactive oxygen species, lipid peroxidation, and activity of some antioxidant enzymes. Expression of some repair enzymes such as poly(ADP-ribose) polymerase and DNA polymerase beta was measured to assess the effect of tea on DNA repair. Tea afforded efficient reduction of As III-induced DNA damage in human lymphocytes. Tea also quenched the excessive production of reactive oxygen species by arsenic, reduced the elevated levels of lipid peroxidation, and increased the activity of antioxidant enzymes such as catalase, superoxide dismutase, and glutathione peroxidase. Furthermore, tea enhanced recovery of DNA damage, which was indicative of repair as confirmed by unscheduled DNA synthesis and pronounced expression of DNA repair enzyme poly(ADP-ribose) polymerase. It is speculated that the antioxidant potential and repair-inducing capacity of tea might help in combating the severe genotoxic effects induced by arsenic in the human population. JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer AU - Sinha, Dona AU - Dey, Subhabrata AU - Bhattacharya, Rathindra Kumar AU - Roy, Madhumita AD - Department of Environmental Carcinogenesis & Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. Y1 - 2007 PY - 2007 DA - 2007 SP - 207 EP - 220 VL - 26 IS - 3 SN - 0731-8898, 0731-8898 KW - Antioxidants KW - 0 KW - Flavonoids KW - Phenols KW - Plant Extracts KW - Polyphenols KW - Reactive Oxygen Species KW - Tea KW - Arsenic KW - N712M78A8G KW - Index Medicus KW - Comet Assay KW - Camellia sinensis -- chemistry KW - Phenols -- pharmacology KW - Cells, Cultured KW - Arsenic Poisoning -- prevention & control KW - Humans KW - Adult KW - Oxidative Stress -- drug effects KW - Flavonoids -- pharmacology KW - Male KW - DNA Damage -- drug effects KW - Plant Extracts -- pharmacology KW - Arsenic -- toxicity KW - Antioxidants -- pharmacology KW - Tea -- chemistry KW - Lymphocytes -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70064155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.atitle=In+vitro+mitigation+of+arsenic+toxicity+by+tea+polyphenols+in+human+lymphocytes.&rft.au=Sinha%2C+Dona%3BDey%2C+Subhabrata%3BBhattacharya%2C+Rathindra+Kumar%3BRoy%2C+Madhumita&rft.aulast=Sinha&rft.aufirst=Dona&rft.date=2007-01-01&rft.volume=26&rft.issue=3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+pathology%2C+toxicology+and+oncology+%3A+official+organ+of+the+International+Society+for+Environmental+Toxicology+and+Cancer&rft.issn=07318898&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-25 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - BP1 transcriptionally activates bcl-2 and inhibits TNFalpha-induced cell death in MCF7 breast cancer cells. AN - 70054424; 17854498 AB - We have previously shown that the Beta Protein 1 (BP1) homeodomain protein is expressed in 81% of invasive ductal breast carcinomas, and that increased BP1 expression correlates with tumor progression. The purpose of our current investigation was to determine whether elevated levels of BP1 in breast cancer cells are associated with increased cell survival. Effects on cell viability and apoptosis of MCF7 cells stably overexpressing BP1 were determined using MTT and Annexin V assays, and through examination of caspase activation. TNFalpha was used to induce apoptosis. The potential regulation of apoptosis-associated genes by BP1 was studied using real-time PCR and western blot analyses. Electrophoretic mobility shift assays, site-directed mutagenesis, and transient assays were performed to specifically characterize the interaction of BP1 with the promoter of the bcl-2 gene. Stable overexpression of BP1 led to inhibition of apoptosis in MCF7 breast cancer cells challenged with TNFalpha. Increased BP1 resulted in reduced processing and activation of caspase-7, caspase-8, and caspase-9, and inactivation of the caspase substrate Poly(ADP-Ribose) Polymerase (PARP). Increased levels of full-length PARP and a decrease in procaspase-8 were also associated with BP1 overexpression. The bcl-2 gene is a direct target of BP1 since: (i) BP1 protein bound to a consensus binding sequence upstream of the bcl-2 P1 promoter in vitro. (ii) MCF7 cells overexpressing BP1 showed increased levels of bcl-2 mRNA and protein. (iii) Transient assays indicated that increased bcl-2 promoter activity is due to direct binding and modulation by BP1 protein. BP1 expression also prevented TNFalpha-mediated downregulation of bcl-2 mRNA and protein. These findings suggest mechanisms by which increased BP1 may impart a survival advantage to breast cancer cells, which could lead to increased resistance to therapeutic agents in patients. JF - Breast cancer research : BCR AU - Stevenson, Holly S AU - Fu, Sidney W AU - Pinzone, Joseph J AU - Rheey, Jinguen AU - Simmens, Samuel J AU - Berg, Patricia E AD - Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 1 VL - 9 IS - 5 KW - Annexin A5 KW - 0 KW - DLX4 protein, human KW - Homeodomain Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - Transcription Factors KW - Tumor Necrosis Factor-alpha KW - Luciferases KW - EC 1.13.12.- KW - Poly(ADP-ribose) Polymerases KW - EC 2.4.2.30 KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Promoter Regions, Genetic KW - Blotting, Western KW - Tumor Cells, Cultured KW - Humans KW - Genetic Vectors KW - Electrophoretic Mobility Shift Assay KW - Luciferases -- metabolism KW - Annexin A5 -- metabolism KW - Poly(ADP-ribose) Polymerases -- metabolism KW - Caspases -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- pathology KW - Transcription Factors -- metabolism KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Homeodomain Proteins -- metabolism KW - Breast Neoplasms -- metabolism KW - Transcription, Genetic KW - Proto-Oncogene Proteins c-bcl-2 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70054424?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Breast+cancer+research+%3A+BCR&rft.atitle=BP1+transcriptionally+activates+bcl-2+and+inhibits+TNFalpha-induced+cell+death+in+MCF7+breast+cancer+cells.&rft.au=Stevenson%2C+Holly+S%3BFu%2C+Sidney+W%3BPinzone%2C+Joseph+J%3BRheey%2C+Jinguen%3BSimmens%2C+Samuel+J%3BBerg%2C+Patricia+E&rft.aulast=Stevenson&rft.aufirst=Holly&rft.date=2007-01-01&rft.volume=9&rft.issue=5&rft.spage=R60&rft.isbn=&rft.btitle=&rft.title=Breast+cancer+research+%3A+BCR&rft.issn=1465-542X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-11 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 1996 Oct;16(10):5546-56 [8816467] Curr Opin Pharmacol. 2006 Aug;6(4):364-8 [16753340] Cell. 1998 Aug 21;94(4):481-90 [9727491] Cell. 1998 Aug 21;94(4):491-501 [9727492] Cancer Res. 1998 Nov 1;58(21):4940-6 [9810003] Clin Cancer Res. 1996 Jul;2(7):1163-7 [9816283] J Cell Biol. 1999 Jan 25;144(2):281-92 [9922454] Blood Cells Mol Dis. 1998 Sep;24(3):356-69 [10087993] J Biol Chem. 1999 Nov 5;274(45):32099-107 [10542244] J Biol Chem. 2000 Mar 31;275(13):9303-7 [10734071] Nature. 2000 Jun 22;405(6789):974-8 [10879542] Leukemia. 2000 Nov;14(11):1867-75 [11069021] J Cell Physiol. 2001 Aug;188(2):161-9 [11424082] Cancer Res. 2001 Sep 1;61(17):6532-9 [11522651] J Allergy Clin Immunol. 2001 Oct;108(4 Suppl):S99-103 [11586274] Oncogene. 2001 Oct 25;20(48):7128-33 [11704839] Gene. 2001 Oct 31;278(1-2):131-9 [11707330] Trends Cell Biol. 2001 Dec;11(12):526-34 [11719060] J Steroid Biochem Mol Biol. 2001 Nov;78(5):409-18 [11738551] Cell. 2002 Jan 25;108(2):153-64 [11832206] Mol Cell Biol. 2002 Apr;22(8):2505-14 [11909945] Pharmacol Rev. 2002 Sep;54(3):375-429 [12223530] J Biol Chem. 2003 Feb 28;278(9):7580-90 [12482855] Breast Cancer Res. 2003;5(4):R82-7 [12817998] Oncogene. 2003 Oct 20;22(47):7414-30 [14576849] Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6478-83 [15123840] Cancer Biol Ther. 2004 Jun;3(6):568-72 [15044858] EMBO J. 1988 Jan;7(1):123-31 [2834197] J Pathol. 2005 Jan;205(2):154-71 [15643670] Oncogene. 2005 Feb 24;24(9):1648-52 [15674342] Breast Cancer Res Treat. 2005 Apr;90(3):241-7 [15830137] J Biol Chem. 1998 Apr 17;273(16):9357-60 [9545256] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case-control study. AN - 70049429; 17875216 AB - Prior studies have suggested abnormalities of serum proteins, including paraproteins, in women with silicone implants but did not control for the presence of connective-tissue disease (CTD). This retrospective case-control study, performed in tertiary-care academic centers, assessed possible alterations of serum proteins, including paraproteins, in such a population. Seventy-four women with silicone implants who subsequently developed CTD, and 74 age-matched and CTD-matched women without silicone implants, were assessed in the primary study; other groups were used for additional comparisons. Routine serum protein determinations and high-sensitivity protein electrophoresis and immunofixation electrophoresis were performed for detection of paraproteins. Women with silicone implants, either with or without CTD, had significantly lower serum total protein and alpha1-globulin, alpha2-globulin, beta-globulin, gamma-globulin, and IgG levels compared with those without silicone implants. There was no significant difference, however, in the frequency of paraproteinemia between women with silicone implants and CTD (9.5%) and age-matched and CTD-matched women without silicone implants (5.4%) (odds ratio, 1.82; 95% confidence interval, 0.51-6.45). Paraprotein isotypes were similar in the two groups, and the clinical characteristics of the 13 women with paraproteinemia were comparable with an independent population of 10 women with silicone breast implants, CTD, and previously diagnosed monoclonal gammopathies. In summary, this first comprehensive study of serum proteins in women with silicone implants and CTD found no substantially increased risk of monoclonal gammopathy. Women with silicone implants, however, had unexpectedly low serum globulin and immunoglobulin levels, with or without the subsequent development of CTD. The causes and clinical implications of these findings require further investigation. JF - Arthritis research & therapy AU - Csako, Gyorgy AU - Costello, Rene AU - Shamim, Ejaz A AU - O'Hanlon, Terrance P AU - Tran, Anthony AU - Clauw, Daniel J AU - Williams, H James AU - Miller, Frederick W AD - Department of Laboratory Medicine, Clinical Center, NIH, DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA. gcsako@nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1 VL - 9 IS - 5 KW - Blood Proteins KW - 0 KW - Paraproteins KW - Silicone Gels KW - Index Medicus KW - Paraproteinemias -- blood KW - Prospective Studies KW - Risk Factors KW - Humans KW - Paraproteinemias -- diagnosis KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Paraproteinemias -- etiology KW - Female KW - Connective Tissue Diseases -- diagnosis KW - Connective Tissue Diseases -- etiology KW - Paraproteins -- metabolism KW - Silicone Gels -- adverse effects KW - Connective Tissue Diseases -- blood KW - Blood Proteins -- metabolism KW - Breast Implants -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/70049429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+research+%26+therapy&rft.atitle=Serum+proteins+and+paraproteins+in+women+with+silicone+implants+and+connective+tissue+disease%3A+a+case-control+study.&rft.au=Csako%2C+Gyorgy%3BCostello%2C+Rene%3BShamim%2C+Ejaz+A%3BO%27Hanlon%2C+Terrance+P%3BTran%2C+Anthony%3BClauw%2C+Daniel+J%3BWilliams%2C+H+James%3BMiller%2C+Frederick+W&rft.aulast=Csako&rft.aufirst=Gyorgy&rft.date=2007-01-01&rft.volume=9&rft.issue=5&rft.spage=R95&rft.isbn=&rft.btitle=&rft.title=Arthritis+research+%26+therapy&rft.issn=1478-6362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-08 N1 - Date created - 2008-01-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: N Engl J Med. 2000 Mar 16;342(11):781-90 [10717013] J Natl Cancer Inst. 1994 Jul 20;86(14):1058-65 [8021954] Aust N Z J Med. 1999 Aug;29(4):500-4 [10868527] Leukemia. 2000 Nov;14(11):1975-9 [11069034] Arch Intern Med. 2001 Mar 26;161(6):864-7 [11268230] Ann Plast Surg. 2004 Nov;53(5):413-9 [15502454] Acta Med Scand. 1966 Feb;179(2):235-47 [4160039] Ann N Y Acad Sci. 1971 Dec 31;190:507-18 [5003017] Medicine (Baltimore). 1977 Jul;56(4):255-86 [327194] J Clin Pathol. 1982 Jan;35(1):63-8 [6801095] Scand J Haematol. 1986 Jan;36(1):103-6 [3081993] J Rheumatol. 1988 Jun;15(6):894-8 [3262160] Arthritis Rheum. 1990 Feb;33(2):160-72 [2306288] Recenti Prog Med. 1990 May;81(5):306-9 [2377807] Sangre (Barc). 1991 Oct;36(5):377-82 [1816635] Autoimmunity. 1992;13(2):101-5 [1467431] Ann Intern Med. 1993 Jun 15;118(12):929-36 [8489106] Br J Surg. 1993 Sep;80(9):1097-100 [8402103] FASEB J. 1993 Oct;7(13):1265-8 [8405812] J Natl Cancer Inst. 1994 Sep 21;86(18):1424 [8072038] Keio J Med. 1994 Jun;43(2):79-87 [8089958] JAMA. 1995 Jan 11;273(2):116 [7799490] Curr Top Microbiol Immunol. 1996;210:337-53 [8565576] Curr Top Microbiol Immunol. 1996;210:357-9 [8565577] Curr Top Microbiol Immunol. 1996;210:361-6 [8565578] Curr Top Microbiol Immunol. 1996;210:367-74 [8565579] Curr Top Microbiol Immunol. 1996;210:375-83 [8565580] Curr Top Microbiol Immunol. 1996;210:397-407 [8565584] Curr Top Microbiol Immunol. 1996;210:411-7 [8565585] Leukemia. 1996 Feb;10(2):327-32 [8637242] Regul Toxicol Pharmacol. 1996 Feb;23(1 Pt 1):74-85 [8628923] Blood. 1996 Jun 1;87(11):4762-9 [8639847] Ann Plast Surg. 1995 Dec;35(6):561-70 [8748335] N Engl J Med. 1997 Mar 6;336(10):677-82 [9041097] Arthritis Rheum. 1997 Sep;40(9):1725 [9324032] Blood. 1997 Nov 1;90(9):3682-90 [9345053] Pathobiology. 1998;66(6):302-5 [9769477] J Rheumatol. 1999 Jan;26(1):73-7 [9918243] Pathol Biol (Paris). 1999 Feb;47(2):119-27 [10192879] J Rheumatol. 1999 Apr;26(4):816-25 [10229402] Am J Med. 1999 Jan;106(1):11-9 [10320112] J Biomed Mater Res. 1999 Jul;46(1):132-4 [10357144] Biomaterials. 1999 Jun;20(11):1063-9 [10378807] Postgrad Med. 1999 Aug;106(2):135-42; quiz 185 [10456045] Arthritis Rheum. 2004 Nov;50(11):3646-50 [15529361] Clin Lymphoma Myeloma. 2005 Sep;6(2):102-14 [16231848] N Engl J Med. 2006 Mar 30;354(13):1362-9 [16571879] Clin Diagn Lab Immunol. 2000 May;7(3):366-70 [10799447] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Appetitive conditioning: neural bases and implications for psychopathology. AN - 69024396; 17210179 AB - Appetitive conditioning is the process through which new rewards are learned and acquire their motivational salience. Although it has the same evolutionary survival significance as aversive conditioning, appetitive conditioning has rarely been studied in humans. This gap may be explained by the difficulty to find in humans suitable appetitive stimuli that can elicit physiological responses similar to those elicited by aversive stimuli. To help remedy this gap, we review the literature on conditioning, with emphasis on appetitive conditioning. This review comprises three parts. First, we examine the different forms of conditioning. Second, we review the neural basis of appetitive conditioning, particularly from a functional neuroimaging perspective. And third, we demonstrate how perturbations in processes involved in appetitive conditioning can contribute to implicated psychopathologies and suggest neurobiological models underlying these pathologies. The ultimate goal of this review is to stimulate new avenues of research that have direct links to molecular biology, and thus could prove to be invaluable to progress in the understanding and treatment of psychiatric disabilities. JF - Neuroscience and biobehavioral reviews AU - Martin-Soelch, C AU - Linthicum, J AU - Ernst, M AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 426 EP - 440 VL - 31 IS - 3 SN - 0149-7634, 0149-7634 KW - Index Medicus KW - Substance-Related Disorders -- physiopathology KW - Depression -- physiopathology KW - Animals KW - Feeding and Eating Disorders -- physiopathology KW - Conditioning, Operant -- physiology KW - Humans KW - Association Learning -- physiology KW - Schizophrenia -- physiopathology KW - Reward KW - Conditioning, Classical -- physiology KW - Mental Disorders -- psychology KW - Brain -- physiology KW - Appetitive Behavior -- physiology KW - Mental Disorders -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69024396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+and+biobehavioral+reviews&rft.atitle=Appetitive+conditioning%3A+neural+bases+and+implications+for+psychopathology.&rft.au=Martin-Soelch%2C+C%3BLinthicum%2C+J%3BErnst%2C+M&rft.aulast=Martin-Soelch&rft.aufirst=C&rft.date=2007-01-01&rft.volume=31&rft.issue=3&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Neuroscience+and+biobehavioral+reviews&rft.issn=01497634&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-28 N1 - Date created - 2007-02-19 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Psychopharmacology (Berl). 1984;84(3):405-12 [6440188] Psychopharmacology (Berl). 1986;90(3):390-7 [3097729] Behav Res Ther. 1989;27(3):279-87 [2730509] Psychol Rev. 1990 Apr;97(2):147-68 [2186423] Addict Behav. 1990;15(4):387-93 [2248111] Cognition. 1990 Nov;37(1-2):105-31 [2269004] Neuroscience. 1991;42(1):1-18 [1830641] Addict Behav. 1991;16(5):247-53 [1776541] Behav Res Ther. 1992 May;30(3):235-41 [1586360] Neurosci Biobehav Rev. 1992 Winter;16(4):525-34 [1480349] Behav Brain Res. 1993 Jun 30;55(2):167-83 [8357526] Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 [8401595] J Pharmacol Exp Ther. 1993 Oct;267(1):250-8 [8229752] Behav Res Ther. 1993 Nov;31(8):731-7 [8257404] Behav Res Ther. 1994 Mar;32(3):291-9 [8192627] J Neurosci. 1994 Jun;14(6):3969-84 [8207500] Neuroscience. 2003;116(1):295-305 [12535961] Learn Mem. 2003 Mar-Apr;10(2):129-40 [12663751] J Comp Neurol. 2003 Jun 2;460(3):425-49 [12692859] Neuron. 2003 Apr 24;38(2):329-37 [12718865] Neuron. 2003 Apr 24;38(2):339-46 [12718866] Ann N Y Acad Sci. 2003 Apr;985:206-17 [12724160] Ann N Y Acad Sci. 2003 Apr;985:233-50 [12724162] Ann N Y Acad Sci. 2003 Apr;985:294-307 [12724166] Trends Neurosci. 2003 Jun;26(6):321-8 [12798602] Behav Neurosci. 2003 Jun;117(3):566-87 [12802885] Neuroimage. 2003 Oct;20(2):1086-95 [14568478] Behav Brain Res. 2003 Nov 30;146(1-2):19-29 [14643456] Neurosci Biobehav Rev. 2004 Jan;27(8):765-76 [15019426] Curr Opin Neurobiol. 2004 Apr;14(2):139-47 [15082317] Science. 2004 Apr 16;304(5669):452-4 [15087550] Nature. 2004 Jun 10;429(6992):664-7 [15190354] Prog Brain Res. 2000;126:263-85 [11105652] J Psychopharmacol. 2000;14(4):340-6 [11198050] Alcohol Clin Exp Res. 2001 Feb;25(2):277-82 [11236843] Curr Opin Neurobiol. 2001 Apr;11(2):240-9 [11301246] Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):104S-109S [11391058] Am J Psychiatry. 2001 Jul;158(7):1075-83 [11431229] J Neural Transm (Vienna). 2001;108(7):887-94 [11515754] Nat Med. 2001 Oct;7(10):1151-4 [11590440] Brain Res Brain Res Rev. 2001 Oct;36(2-3):139-49 [11690610] Alcohol Clin Exp Res. 2001 Oct;25(10):1414-9 [11696659] Psychol Bull. 2001 Nov;127(6):853-69 [11726074] Neuroreport. 2001 Dec 4;12(17):3683-7 [11726774] J Pharmacol Exp Ther. 2002 Mar;300(3):882-9 [11861794] Schizophr Res. 2002 May 1;55(1-2):147-58 [11955974] J Neurosci. 2002 May 1;22(9):3332-7 [11978808] Behav Neurosci. 2002 Apr;116(2):267-75 [11996312] Behav Neurosci. 1996 Oct;110(5):981-90 [8919000] Psychophysiology. 1996 Nov;33(6):698-710 [8961792] J Neurosci. 1997 Jul 1;17(13):5237-44 [9185561] Psychopharmacology (Berl). 1997 Jul;132(1):104-6 [9272766] Exp Brain Res. 1997 Oct;116(3):456-66 [9372294] Science. 1994 Jul 15;265(5170):412-5 [8023166] Psychopharmacology (Berl). 1993;110(3):355-64 [7831431] Psychol Bull. 1995 Jan;117(1):87-103 [7870865] J Neurosci. 1996 Aug 15;16(16):5256-65 [8756453] J Neurosci. 1996 Mar 1;16(5):1936-47 [8774460] J Comp Neurol. 1995 Dec 25;363(4):615-641 [8847421] Neurosci Biobehav Rev. 2002 May;26(3):321-52 [12034134] Alcohol Clin Exp Res. 1999 Nov;23(11):1751-60 [10591591] Biol Psychiatry. 1999 Dec 15;46(12):1624-33 [10624543] Behav Neurosci. 2000 Feb;114(1):42-63 [10718261] Cereb Cortex. 2000 Mar;10(3):334-42 [10731228] Conscious Cogn. 2000 Mar;9(1):13-36 [10753490] Eur J Pharmacol. 2000 Mar 30;393(1-3):295-314 [10771025] J Exp Psychol Anim Behav Process. 2000 Apr;26(2):237-42 [10782437] J Neurosci. 2000 Jun 1;20(11):4311-9 [10818166] Learn Mem. 2000 Sep-Oct;7(5):257-66 [11040256] Neuron. 2006 Jan 5;49(1):157-66 [16387647] J Neurosci. 2006 May 31;26(22):6004-10 [16738243] J Neurosci. 2006 Jun 14;26(24):6583-8 [16775146] Annu Rev Neurosci. 2006;29:565-98 [16776597] Neuropsychopharmacology. 2006 Dec;31(12):2716-27 [16971900] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):12040-5 [8876259] Annu Rev Neurosci. 2002;25:563-93 [12052921] Eur J Neurosci. 2002 Jun;15(11):1841-53 [12081664] Neuropsychopharmacology. 2002 Sep;27(3):391-9 [12225696] J Neurosci. 2002 Dec 15;22(24):10829-37 [12486176] J Neurosci. 2003 Jan 1;23(1):303-7 [12514228] Behav Neurosci. 1997 Oct;111(5):908-19 [9383513] J Neurosci. 1998 Apr 1;18(7):2613-25 [9502820] Science. 1998 May 1;280(5364):747-9 [9563953] J Psychopharmacol. 1998;12(1):15-22 [9584964] Prog Neurobiol. 1998 Jun;55(3):257-332 [9643556] Behav Res Ther. 1998 Mar;36(3):257-72 [9642846] J Neurophysiol. 1998 Jul;80(1):1-27 [9658025] J Neurophysiol. 1998 Aug;80(2):947-63 [9705481] J Neurophysiol. 1998 Aug;80(2):964-77 [9705482] Appetite. 1998 Oct;31(2):185-204 [9792732] J Neurosci. 1998 Dec 15;18(24):10663-71 [9852601] Am J Psychiatry. 1999 Jan;156(1):11-8 [9892292] J Neurosci. 1999 Mar 1;19(5):1876-84 [10024371] Nat Neurosci. 1998 Jun;1(2):155-9 [10195132] Nat Neurosci. 1998 Sep;1(5):411-6 [10196532] Nature. 1999 Apr 15;398(6728):567-70 [10217139] J Exp Psychol Anim Behav Process. 1999 Apr;25(2):211-24 [10331920] Behav Brain Res. 1999 Jun;101(2):129-52 [10372570] J Neurosci. 1999 Aug 1;19(15):6610-4 [10414988] J Neurosci. 1999 Aug 1;19(15):6615-22 [10414989] Ann N Y Acad Sci. 1999 Jun 29;877:397-411 [10415661] Eur J Pharmacol. 1999 Jun 30;375(1-3):13-30 [10443561] J Exp Psychol. 1954 Oct;48(4):278-82 [13211939] J Exp Psychol. 1957 Jul;54(1):74-80 [13449253] Trends Cogn Sci. 2004 Dec;8(12):539-46 [15556023] J Neurosci. 2005 Mar 9;25(10):2733-40 [15758183] Neuron. 2005 Apr 21;46(2):321-31 [15848809] Curr Opin Neurol. 2005 Aug;18(4):411-7 [16003117] Am J Psychiatry. 2005 Aug;162(8):1403-13 [16055761] Nat Neurosci. 2005 Sep;8(9):1234-40 [16116445] Neuron. 2005 Sep 1;47(5):633-6 [16129393] J Anat. 2005 Sep;207(3):271-82 [16185252] Nicotine Tob Res. 2004 Jun;6(3):523-32 [15203786] Neuropharmacology. 2004;47 Suppl 1:3-13 [15464121] Behav Res Ther. 1975 Oct;13(4):221-6 [1191163] Science. 1983 Apr 22;220(4595):431-3 [6836286] Proc Natl Acad Sci U S A. 1984 Aug;81(15):4998-5001 [6589643] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - A favorable view: progress in cancer prevention and screening. AN - 69009121; 17302181 AB - Clifton Leaf, in his article "Why We're Losing the War on Cancer," presents criticisms of past research approaches and the small impact of this research thus far on producing cures or substantially extending the life of many cancer patients. It is true that gains in long-term survival for people with advanced cancers have been modest, hindered in part by the heterogeneity of tumors, which allows the cancers to persist using alternate molecular pathways and so evade many cancer therapeutics. In contrast, clinical trials have demonstrated that it is possible to reduce the incidence or improve cancer survival through prevention and early detection. Strides have been made in preventing or detecting early the four deadliest cancers in the United States (i.e., lung, breast, prostate, and colorectal). For example, 7-year follow-up data from the Breast Cancer Prevention Trial (BCPT) provides evidence that tamoxifen reduces the occurrence of invasive breast tumors by more than 40%; recent studies using aromatase inhibitors and raloxifene are also promising. The Prostate Cancer Prevention Trial (PCPT) showed that finasteride reduced prostate cancer incidence by 25%, and the ongoing Selenium and Vitamin E Cancer Prevention Trial (SELECT) is investigating selenium and vitamin E for prostate cancer prevention based on encouraging results from earlier studies. Living a healthy lifestyle, including regular physical activity, avoiding obesity, and eating primarily a plant-based diet has been associated with a lower risk of colorectal cancer. In addition, noninvasive stool DNA tests for early detection are being studied, which may lessen the reluctance of people to be screened for colorectal polyps and cancer. Behavioral and medical approaches for smoking prevention are ways to reduce the incidence of lung cancer, with antinicotine vaccines on the horizon that may help former smokers to avoid relapse. The US National Lung Screening Trial is testing whether early detection via spiral CT screening will reduce lung cancer mortality. Prevention and earlier detection offer efficient and practical strategies to reduce the cancer burden. Several of the suggestions Mr. Leaf makes, such as developing interdisciplinary collaborations and allocating resources to research earlier in the process of carcinogenesis, have become an integral strategy in the National Cancer Institute's (NCI) approach in the past decade, specifically in the realm of cancer prevention and early detection. For example, an aggressive program to identify biomarkers for earlier detection of cancer--the NCI's Early Detection Research Detection (EDRN)--has identified three promising biomarkers since its establishment in 2000. It collaborates with the National Institute of Standards and Technology and extramural scientists to develop validation standards and to identify the best technologies to use for systematic investigations. If these biomarkers can be validated, they might help to reduce cancer mortality. JF - Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer AU - Greenwald, Peter AD - Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7309, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 3 EP - 17 VL - 174 SN - 0080-0015, 0080-0015 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Mass Screening -- methods KW - Neoplasms -- prevention & control KW - Early Diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69009121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Recent+results+in+cancer+research.+Fortschritte+der+Krebsforschung.+Progres+dans+les+recherches+sur+le+cancer&rft.atitle=A+favorable+view%3A+progress+in+cancer+prevention+and+screening.&rft.au=Greenwald%2C+Peter&rft.aulast=Greenwald&rft.aufirst=Peter&rft.date=2007-01-01&rft.volume=174&rft.issue=&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Recent+results+in+cancer+research.+Fortschritte+der+Krebsforschung.+Progres+dans+les+recherches+sur+le+cancer&rft.issn=00800015&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-02-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Puberty, hormones, and sex differences in alcohol abuse and dependence. AN - 68996009; 17174531 AB - Sex differences in patterns of drinking and rates of alcohol abuse and dependence begin to emerge during the transition from late puberty to young adulthood. Increases in pubertal hormones, including gonadal and stress hormones, are a prominent developmental feature of adolescence and could contribute to the progression of sex differences in alcohol drinking patterns during puberty. This paper reviews experimental and correlational studies of gonadal and stress-related hormone changes and their effects on alcohol drinking and other associated actions of alcohol. Mechanisms are suggested by which reproductive hormones and stress-related hormones may modulate neural circuits within the brain reward system to produce sex differences in alcohol drinking patterns and vulnerability to alcohol abuse and dependence which become apparent during the late pubertal period. JF - Neurotoxicology and teratology AU - Witt, Ellen D AD - Division of Neuroscience and Behavior National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, USA. ewitt@mail.nih.gov PY - 2007 SP - 81 EP - 95 VL - 29 IS - 1 SN - 0892-0362, 0892-0362 KW - Hormones KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Sex Characteristics KW - Hormones -- metabolism KW - Alcoholism -- metabolism KW - Alcoholism -- physiopathology KW - Alcoholism -- psychology KW - Puberty UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68996009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+teratology&rft.atitle=Puberty%2C+hormones%2C+and+sex+differences+in+alcohol+abuse+and+dependence.&rft.au=Witt%2C+Ellen+D&rft.aulast=Witt&rft.aufirst=Ellen&rft.date=2007-01-01&rft.volume=29&rft.issue=1&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+teratology&rft.issn=08920362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-02-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurological aspects of chemical terrorism. AN - 68970802; 17262854 JF - Annals of neurology AU - Jett, David A AD - National Institutes of Health, National Institute of Neurological Disorders and Stroke, Office of Technology Development, Bethesda, MD 20892-9527, USA. jettd@ninds.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 9 EP - 13 VL - 61 IS - 1 SN - 0364-5134, 0364-5134 KW - Chemical Warfare Agents KW - 0 KW - Index Medicus KW - Humans KW - Chemical Warfare Agents -- poisoning KW - Nervous System Diseases -- etiology KW - Chemical Terrorism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+neurology&rft.atitle=Neurological+aspects+of+chemical+terrorism.&rft.au=Jett%2C+David+A&rft.aulast=Jett&rft.aufirst=David&rft.date=2007-01-01&rft.volume=61&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Annals+of+neurology&rft.issn=03645134&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes. AN - 68968960; 17266554 AB - Crystal structures of HIV-1 reverse transcriptase (RT) in complex with either duplex DNA or an RNA/DNA hybrid have provided significant insights into the manner in which this highly versatile enzyme accommodates the conformationally-distinct nucleic acid substrates encountered during the reverse transcription cycle. Biochemical data likewise suggest that unique structural features of the nucleic acid substrates contribute towards recognition by their cognate RT. While site-directed mutagenesis of catalytically- and structurally-critical protein motifs is relatively facile, understanding how nucleic acid structure contributes to its recognition presents a greater challenge. The relative ease with which large DNA and RNA fragments can now be chemically synthesized, in conjunction with the increased availability of ribo- and deoxyribonucleoside analogs, allows nucleic acid structure to be examined with respect to the role of hydrogen bonding, nucleobase stacking, sugar ring geometry and charge of the phosphodiester backbone. This review summarizes our use of nucleoside analogs to understand how the structure of cis-acting regulatory signals mediates their recognition by structurally diverse retroviral and retrotransposon enzymes. JF - Current HIV research AU - Rausch, Jason W AU - Le Grice, Stuart F J AD - RT Biochemistry Section, HIV Drug Resistance Program, National Cancer Institute at Frederick, Frederick MD 21702, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 11 EP - 22 VL - 5 IS - 1 KW - DNA, Viral KW - 0 KW - Nucleosides KW - RNA, Viral KW - HIV Reverse Transcriptase KW - EC 2.7.7.49 KW - Index Medicus KW - HIV-1 -- genetics KW - DNA, Viral -- biosynthesis KW - DNA, Viral -- chemistry KW - RNA, Viral -- chemistry KW - Hydrogen Bonding KW - HIV Reverse Transcriptase -- chemistry KW - Reverse Transcription KW - Nucleosides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+HIV+research&rft.atitle=Exploiting+structurally+diverse+nucleoside+analogs+as+probes+of+reverse+transcription+complexes.&rft.au=Rausch%2C+Jason+W%3BLe+Grice%2C+Stuart+F+J&rft.aulast=Rausch&rft.aufirst=Jason&rft.date=2007-01-01&rft.volume=5&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Current+HIV+research&rft.issn=1873-4251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2007-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - miRNAs in the biology of cancers and viral infections. AN - 68966030; 17266578 AB - MicroRNAs (miRNAs) are non-coding small RNAs that play important roles in a variety of biological pathways including cellular proliferation and apoptosis. Recent studies have linked the expression of selected miRNAs to carcinogenesis and viral pathogenesis. Here, we will discuss examples of roles served by cellular miRNAs and virus-encoded miRNAs in the development of cancers and viral diseases. JF - Current medicinal chemistry AU - Yeung, Man Lung AU - Bennasser, Yamina AU - Jeang, Kuan-Teh AD - Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-0460, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 191 EP - 197 VL - 14 IS - 2 SN - 0929-8673, 0929-8673 KW - MicroRNAs KW - 0 KW - Index Medicus KW - Apoptosis KW - Humans KW - Cell Proliferation KW - Virus Diseases -- genetics KW - MicroRNAs -- physiology KW - Neoplasms -- genetics KW - Neoplasms -- etiology KW - Virus Diseases -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68966030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+medicinal+chemistry&rft.atitle=miRNAs+in+the+biology+of+cancers+and+viral+infections.&rft.au=Yeung%2C+Man+Lung%3BBennasser%2C+Yamina%3BJeang%2C+Kuan-Teh&rft.aulast=Yeung&rft.aufirst=Man&rft.date=2007-01-01&rft.volume=14&rft.issue=2&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Current+medicinal+chemistry&rft.issn=09298673&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2007-02-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bleeding patterns after misoprostol vs surgical treatment of early pregnancy failure: results from a randomized trial. AN - 68934541; 17240222 AB - The purpose of this study was to describe bleeding patterns after misoprostol or curettage for early pregnancy failure (EPF). This was a randomized trial that included women (n = 652) with EPF. Participants were assigned to vaginal misoprostol (800 microg) or curettage in a 3:1 ratio. Participants completed a bleeding diary. We measured hemoglobin levels at baseline and 2 weeks after the treatment. Decreases in hemoglobin levels were greater after misoprostol (-0.7 g/dL; SD, 1.2) than curettage (-0.2 g/dL; SD, 0.9; P < .001). Large changes in hemoglobin levels (at least 2 g/dL) or low nadir hemoglobin levels (< 10 g/dL) were more frequent after misoprostol (55/428 women; 12.8%) than after curettage (6/135 women; 4.4%; P = .02). More participants in the misoprostol group reported "any bleeding" or "heavy bleeding" every study day. Four women who were treated with misoprostol required blood transfusion. Bleeding is heavier and more prolonged after medical treatment with misoprostol than with curettage for EPF; however, bleeding rarely requires intervention. JF - American journal of obstetrics and gynecology AU - Davis, Anne R AU - Hendlish, Sarah K AU - Westhoff, Carolyn AU - Frederick, Margaret M AU - Zhang, Jun AU - Gilles, Jerry M AU - Barnhart, Kurt AU - Creinin, Mitchell D AU - National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial AD - Columbia University, Department of Obstetrics & Gynecology, 622 West 168th St, PH 16 Room 80, New York, NY 10032, USA. ard4@columbia.edu ; National Institute of Child Health and Human Development Management of Early Pregnancy Failure Trial Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 31.e1 EP - 7 VL - 196 IS - 1 KW - Abortifacient Agents, Nonsteroidal KW - 0 KW - Misoprostol KW - 0E43V0BB57 KW - Abridged Index Medicus KW - Index Medicus KW - Humans KW - Adult KW - Female KW - Pregnancy KW - Misoprostol -- adverse effects KW - Curettage KW - Abortifacient Agents, Nonsteroidal -- adverse effects KW - Uterine Hemorrhage -- epidemiology KW - Abortion, Spontaneous -- surgery KW - Abortion, Spontaneous -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Bleeding+patterns+after+misoprostol+vs+surgical+treatment+of+early+pregnancy+failure%3A+results+from+a+randomized+trial.&rft.au=Davis%2C+Anne+R%3BHendlish%2C+Sarah+K%3BWesthoff%2C+Carolyn%3BFrederick%2C+Margaret+M%3BZhang%2C+Jun%3BGilles%2C+Jerry+M%3BBarnhart%2C+Kurt%3BCreinin%2C+Mitchell+D%3BNational+Institute+of+Child+Health+and+Human+Development+Management+of+Early+Pregnancy+Failure+Trial&rft.aulast=Davis&rft.aufirst=Anne&rft.date=2007-01-01&rft.volume=196&rft.issue=1&rft.spage=31.e1&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-08 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101. AN - 68933158; 17237265 AB - Histone deacetylase inhibitors (HDI) can inhibit proliferation and enhance apoptosis in a wide range of malignancies. However, HDIs show relatively modest activity in head and neck squamous cell carcinomas (HNSCC), in which we have shown the activation of nuclear factor-kappaB (NF-kappaB; NF-kappaB1/RelA or p50/p65), a transcription factor that promotes expression of proliferative and antiapoptotic genes. In this study, we examined if HDIs enhance activation of NF-kappaB and target genes and if genetic or pharmacologic inhibition of NF-kappaB can sensitize HNSCC to HDIs. Limited activity of classic HDIs trichostatin A and sodium butyrate was associated with enhanced activation of NF-kappaB reporter activity in a panel of six HNSCC cell lines. HDIs enhanced NF-kappaB p50/p65 DNA binding and acetylation of the RelA p65 subunit. Transfection of small interfering RNAs targeting p65 strongly inhibited NF-kappaB expression and activation, induced cell cycle arrest and cell death, and further sensitized HNSCC cells when combined with HDIs. The p65 small interfering RNA inhibited HDI-enhanced expression of several NF-kappaB-inducible genes implicated in oncogenesis of HNSCC, such as p21, cyclin D1, and BCL-XL. Bortezomib, an inhibitor of proteasome-dependent NF-kappaB activation, also increased sensitization to trichostatin A, sodium butyrate, and a novel HDI, PXD101, in vitro, and to the antitumor effects of PXD101 in bortezomib-resistant UMSCC-11A xenografts. However, gastrointestinal toxicity, weight loss, and mortality of the combination were dose limiting and required parenteral fluid administration. We conclude that HDI-enhanced NF-kappaB activation is one of the major mechanisms of resistance of HNSCC to HDIs. The combination of HDI and proteasome inhibitor produced increased antitumor activity. Low starting dosages for clinical studies combining HDIs with proteasome inhibitors and IV fluid support may be warranted. JF - Molecular cancer therapeutics AU - Duan, Jianming AU - Friedman, Jay AU - Nottingham, Liesl AU - Chen, Zhong AU - Ara, Gulshan AU - Van Waes, Carter AD - National Institute on Deafness and Other Communication Disorders, NIH, CRC Building 10, Room 4-2732, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 37 EP - 50 VL - 6 IS - 1 SN - 1535-7163, 1535-7163 KW - Antineoplastic Agents KW - 0 KW - Boronic Acids KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA, Neoplasm KW - Enzyme Inhibitors KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Inhibitor of Apoptosis Proteins KW - NF-kappa B p50 Subunit KW - Proteasome Inhibitors KW - Pyrazines KW - RNA, Small Interfering KW - Sulfonamides KW - Transcription Factor RelA KW - bcl-X Protein KW - Cyclin D1 KW - 136601-57-5 KW - Bortezomib KW - 69G8BD63PP KW - belinostat KW - F4H96P17NZ KW - Index Medicus KW - Animals KW - Acetylation -- drug effects KW - Antineoplastic Agents -- administration & dosage KW - Humans KW - Cyclin-Dependent Kinase Inhibitor p21 -- genetics KW - Mice KW - Cyclin D1 -- genetics KW - Drug Resistance, Neoplasm KW - bcl-X Protein -- metabolism KW - Protein Binding -- drug effects KW - Inhibitor of Apoptosis Proteins -- genetics KW - Antineoplastic Combined Chemotherapy Protocols KW - Xenograft Model Antitumor Assays KW - Enzyme Inhibitors -- pharmacology KW - Mice, SCID KW - Down-Regulation -- drug effects KW - Antineoplastic Agents -- pharmacology KW - DNA, Neoplasm -- metabolism KW - NF-kappa B p50 Subunit -- metabolism KW - Boronic Acids -- pharmacology KW - Hydroxamic Acids -- therapeutic use KW - Transcription Factor RelA -- metabolism KW - Pyrazines -- therapeutic use KW - Pyrazines -- pharmacology KW - Head and Neck Neoplasms -- pathology KW - RNA, Small Interfering -- metabolism KW - Head and Neck Neoplasms -- drug therapy KW - Pyrazines -- administration & dosage KW - Head and Neck Neoplasms -- enzymology KW - Hydroxamic Acids -- administration & dosage KW - Boronic Acids -- administration & dosage KW - Carcinoma, Squamous Cell -- pathology KW - Boronic Acids -- therapeutic use KW - Carcinoma, Squamous Cell -- drug therapy KW - Hydroxamic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68933158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Nuclear+factor-kappaB+p65+small+interfering+RNA+or+proteasome+inhibitor+bortezomib+sensitizes+head+and+neck+squamous+cell+carcinomas+to+classic+histone+deacetylase+inhibitors+and+novel+histone+deacetylase+inhibitor+PXD101.&rft.au=Duan%2C+Jianming%3BFriedman%2C+Jay%3BNottingham%2C+Liesl%3BChen%2C+Zhong%3BAra%2C+Gulshan%3BVan+Waes%2C+Carter&rft.aulast=Duan&rft.aufirst=Jianming&rft.date=2007-01-01&rft.volume=6&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lymphocyte loss and immunosuppression following acetaminophen-induced hepatotoxicity in mice as a potential mechanism of tolerance. AN - 68923670; 17226923 AB - Current evidence suggests that drug-induced liver disease can be caused by an allergic response (drug-induced allergic hepatitis, DIAH) induced by hepatic drug-protein adducts. The relatively low incidence of these reactions has led us to hypothesize that tolerogenic mechanisms prevent DIAH from occurring in most people. Here, we present evidence for the existence of one of these regulatory pathways. Following a hepatotoxic dose of acetaminophen in C57Bl/6 mice, lymphocyte loss that appeared to be due at least in part to apoptosis was noted in the spleen, thymus, and draining lymph nodes of the liver. There was no observable lymphocyte loss in the absence of hepatotoxicity. Acetaminophen-induced liver injury (AILI) also led to a functional suppression of the immune system as determined by the inhibition of a delayed-type hypersensitivity response to dinitrochlorobenzene. Further studies with adrenalectomized mice suggested a role for corticosterone in the depletion of lymphocytes following APAP-induced liver injury. In conclusion, these findings suggest that lymphocyte loss and immunosuppression following AILI may prevent subsequent occurrences of allergic hepatitis and possibly other forms of APAP-induced allergies induced by hepatic drug-protein adducts. Similar regulatory pathways may inhibit other hepatotoxic drugs from causing allergic reactions. JF - Chemical research in toxicology AU - Masson, Mary Jane AU - Peterson, Richard A AU - Chung, Christine J AU - Graf, Mary L AU - Carpenter, Leah D AU - Ambroso, Jeffrey L AU - Krull, David L AU - Sciarrotta, Janeice AU - Pohl, Lance R AD - Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA. massonm@nhlbi.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 20 EP - 26 VL - 20 IS - 1 SN - 0893-228X, 0893-228X KW - Acetaminophen KW - 362O9ITL9D KW - Corticosterone KW - W980KJ009P KW - Index Medicus KW - Animals KW - Corticosterone -- blood KW - Mice, Inbred C57BL KW - Mice KW - Male KW - Liver -- drug effects KW - Lymphocyte Depletion KW - Adaptation, Physiological KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68923670?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Lymphocyte+loss+and+immunosuppression+following+acetaminophen-induced+hepatotoxicity+in+mice+as+a+potential+mechanism+of+tolerance.&rft.au=Masson%2C+Mary+Jane%3BPeterson%2C+Richard+A%3BChung%2C+Christine+J%3BGraf%2C+Mary+L%3BCarpenter%2C+Leah+D%3BAmbroso%2C+Jeffrey+L%3BKrull%2C+David+L%3BSciarrotta%2C+Janeice%3BPohl%2C+Lance+R&rft.aulast=Masson&rft.aufirst=Mary&rft.date=2007-01-01&rft.volume=20&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2007-01-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal alcohol syndrome: historical perspectives. AN - 68920387; 17224346 AB - Fetal alcohol syndrome (FAS), the most severe manifestation of the adverse effects of alcohol on foetal development, was first described in the French medical literature by Lemoine et al. in 1968 [Les Gfants des parents alcholiques: anomalies observes a propos de 127 cas (The children of alchoholic parents: anomalies observed in 127 cases). Quert in Medicine 8, 476-482]. Five years later, Jones et al., 1973. Pattern of malformation in offspring of chronic alcholic mothers. Lancet 1, 1129-1267] were the first to delineate systematically the association between maternal alcohol abuse and a specific pattern of birth defects and to provide diagnostic criteria for this condition. Several diagnostic systems have since been developed with a view to capturing the wide spectrum of physical and behavioral anomalies resulting from prenatal alcohol exposure. The purpose of the current paper is to outline the evolution of FAS as a medical diagnosis. JF - Neuroscience and biobehavioral reviews AU - Calhoun, Faye AU - Warren, Kenneth AD - National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Bethesda, MD, USA. fcalhoun@willco.niaaa.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 168 EP - 171 VL - 31 IS - 2 SN - 0149-7634, 0149-7634 KW - Index Medicus KW - History, 21st Century KW - History, 20th Century KW - Humans KW - History, 18th Century KW - History, 19th Century KW - Female KW - Pregnancy KW - Fetal Alcohol Spectrum Disorders -- history KW - Fetal Alcohol Spectrum Disorders -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68920387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+and+biobehavioral+reviews&rft.atitle=Fetal+alcohol+syndrome%3A+historical+perspectives.&rft.au=Calhoun%2C+Faye%3BWarren%2C+Kenneth&rft.aulast=Calhoun&rft.aufirst=Faye&rft.date=2007-01-01&rft.volume=31&rft.issue=2&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Neuroscience+and+biobehavioral+reviews&rft.issn=01497634&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-17 N1 - Date created - 2007-01-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monitoring rare serious adverse events from a new treatment and testing for a difference from historical controls. AN - 68551491; 18042569 AB - We detail the design of a study to monitor the safety of including albendazole to an existing treatment regimen to eliminate lymphatic filariasis. We wish to show that this new regimen does not increase the rate of a rare serious adverse event (SAE) compared to the old regimen. Controlled but small clinical trials have not detected any increase in the SAE using albendazole, and it is known to have added benefits; therefore, it is unethical to randomize patients to the old regimen. A sample size for the new regimen is needed to test that the new rate of SAE is noninferior to the historic rate. If the new regimen does have an inferior rate of SAE then we wish to stop the study early. This setup is different from traditional early stopping for efficacy and futility. In that traditional case, the two stopping decisions are relative to the same null hypothesis of equality, while in our setup, we have two different null hypotheses: the noninferiority null and the equality null. When testing the former, we need not stop early if the new regimen appears better because no subjects are receiving the old regimen anymore anyway. When testing the equality of SAE rates, however, we want to stop early if the new regimen has a significantly higher rate of SAE. We create a design that uses an exact difference in proportions test for testing noninferiority, but calculates maximal sample size based on conditional power which treats the historical rates as true rates. The design allows for early stopping if the new treatment appears inferior with respect to SAE rate but makes no corrections for multiple testing. We explore the properties of this naive design without assuming the historical rates are known. For our example, we show that our naive design strategy bounds the type I error of the noninferiority hypothesis in all cases and bounds it for the equality hypothesis at 0.05, as long as the true SAE rate is <0.00015. The same design has unconditional power for the noninferiority hypothesis greater than the nominal 80% as long as the true SAE rate for both regimens are <0.00025. The type I and power results above hold only for our historical sample size of 17,877. We expect similar type I and power properties to hold with studies with SAE rates similar or less (i.e., < 0.00015) and historical sample sizes similar or smaller. Our design for comparing very rare historical SAE rates to SAE rates of a new treatment has large power to conclude noninferiority of the new treatment SAE rate when both rates are equal, but allows early stopping if the new SAE rates are worse. JF - Clinical trials (London, England) AU - Fay, Michael P AU - Huang, Chiung-Yu AU - Twum-Danso, Nana A Y AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive, Bethesda, MD 20892-7609, USA. mfay@niaid.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 598 EP - 610 VL - 4 IS - 6 SN - 1740-7745, 1740-7745 KW - Antinematodal Agents KW - 0 KW - Albendazole KW - F4216019LN KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Therapies, Investigational -- statistics & numerical data KW - Treatment Outcome KW - Models, Statistical KW - Research Design KW - Therapies, Investigational -- adverse effects KW - Drug Monitoring -- methods KW - Albendazole -- adverse effects KW - Antinematodal Agents -- adverse effects KW - Drug Monitoring -- statistics & numerical data KW - Elephantiasis, Filarial -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68551491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+trials+%28London%2C+England%29&rft.atitle=Monitoring+rare+serious+adverse+events+from+a+new+treatment+and+testing+for+a+difference+from+historical+controls.&rft.au=Fay%2C+Michael+P%3BHuang%2C+Chiung-Yu%3BTwum-Danso%2C+Nana+A+Y&rft.aulast=Fay&rft.aufirst=Michael&rft.date=2007-01-01&rft.volume=4&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=Clinical+trials+%28London%2C+England%29&rft.issn=17407745&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-03-25 N1 - Date created - 2007-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CONF T1 - Pain, opioids, and addiction: an urgent problem for doctors and patients. AN - 68546640; 18032317 AB - In March 2007, the National Institute of Drug Abuse (NIDA) of the National Institutes of Health (NIH) conducted a meeting on opioid prescribing, chronic pain and prescription drug abuse in collaboration with the American Medical Association. The meeting was held on the NIH campus in Bethesda, Maryland. This report summarizes major presentations presented at the meeting. JF - Journal of pain & palliative care pharmacotherapy AU - National Institute of Drug Abuse AU - National Institutes of Health Y1 - 2007 PY - 2007 DA - 2007 SP - 45 EP - 49 VL - 21 IS - 4 KW - Analgesics, Opioid KW - 0 KW - Dosage Forms KW - Receptors, Opioid KW - Index Medicus KW - Smoking KW - Humans KW - Palliative Care KW - Pain Measurement KW - Chronic Disease KW - Behavior, Addictive -- genetics KW - Receptors, Opioid -- physiology KW - Practice Patterns, Physicians' KW - Pain -- drug therapy KW - Opioid-Related Disorders -- epidemiology KW - Analgesics, Opioid -- therapeutic use KW - Pain -- genetics KW - Analgesics, Opioid -- adverse effects KW - Opioid-Related Disorders -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68546640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.atitle=Pain%2C+opioids%2C+and+addiction%3A+an+urgent+problem+for+doctors+and+patients.&rft.au=National+Institute+of+Drug+Abuse%3BNational+Institutes+of+Health&rft.aulast=National+Institute+of+Drug+Abuse&rft.aufirst=&rft.date=2007-01-01&rft.volume=21&rft.issue=4&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=Journal+of+pain+%26+palliative+care+pharmacotherapy&rft.issn=15360288&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-29 N1 - Date created - 2007-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Carcinogenicity of agricultural pesticides in adults and children. AN - 68543888; 18032335 AB - The role of specific agricultural pesticides in relation to adult and childhood cancers has not been firmly established due to the lack of precise exposure data in previous studies. Improvements in exposure assessment, disease classification, and application of molecular techniques in recent epidemiological evaluations is rapidly improving our ability to evaluate the human carcinogenicity of agricultural pesticides. The role of pesticide exposures in the etiology of human cancer is outlined by anatomical site and recent development in exposure assessment and molecular epidemiology are summarized and evaluated. JF - Journal of agromedicine AU - Alavanja, Michael C R AU - Ward, Mary H AU - Reynolds, Peggy AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. alavanjm@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 39 EP - 56 VL - 12 IS - 1 SN - 1059-924X, 1059-924X KW - Pesticides KW - 0 KW - Index Medicus KW - Occupational Exposure KW - Humans KW - Adult KW - Environmental Exposure KW - Child KW - Neoplasms -- chemically induced KW - Agricultural Workers' Diseases -- chemically induced KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68543888?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+agromedicine&rft.atitle=Carcinogenicity+of+agricultural+pesticides+in+adults+and+children.&rft.au=Alavanja%2C+Michael+C+R%3BWard%2C+Mary+H%3BReynolds%2C+Peggy&rft.aulast=Alavanja&rft.aufirst=Michael+C&rft.date=2007-01-01&rft.volume=12&rft.issue=1&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+agromedicine&rft.issn=1059924X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-03 N1 - Date created - 2007-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The yin and yang of stem cell gene therapy: insights into hematopoiesis, leukemogenesis, and gene therapy safety. AN - 68527386; 18024665 AB - Over the past decade, success in the treatment of serious genetic disorders via gene therapy was finally achieved. However, this progress was tempered by the occurrence of serious adverse events related to vector integration into the genome and activation of adjacent proto-oncogenes. Investigators are now focused on retaining the clinical potential of integrating vectors while decreasing the risk of insertional mutagenesis. JF - Hematology. American Society of Hematology. Education Program AU - Dunbar, Cynthia E AD - Hematology Branch, NIH, Building 10, Room 7C103, 9000 Rockville Pike, Bethesda, MD 20892, USA. dunbarc@nhlbi.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 460 EP - 465 SN - 1520-4391, 1520-4391 KW - Index Medicus KW - Humans KW - Genetic Vectors KW - Virus Integration KW - Retroviridae -- genetics KW - Genetic Therapy -- adverse effects KW - Leukemia -- etiology KW - Hematopoiesis -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68527386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology.+American+Society+of+Hematology.+Education+Program&rft.atitle=The+yin+and+yang+of+stem+cell+gene+therapy%3A+insights+into+hematopoiesis%2C+leukemogenesis%2C+and+gene+therapy+safety.&rft.au=Dunbar%2C+Cynthia+E&rft.aulast=Dunbar&rft.aufirst=Cynthia&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=460&rft.isbn=&rft.btitle=&rft.title=Hematology.+American+Society+of+Hematology.+Education+Program&rft.issn=15204391&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Familial CLL: genes and environment. AN - 68527340; 18024649 AB - Families with multiple individuals affected with chronic lymphocytic leukemia (CLL) and other related B-cell tumors have been described in the literature. Familial CLL does not appear to differ from sporadic CLL in terms of prognostic markers and clinical outcome. While some environmental factors (such as farming-related exposures and occupational chemicals) may increase risk of CLL, results of epidemiologic studies have been generally inconsistent. Rates of CLL in the population show significant international variation, with the highest rates in the U.S. and Europe and the lowest rates in Asia. Migrants from Asia to the U.S. also have low rates of CLL, which supports a greater role for genetic compared with environmental risk factors. Large, population-based case-control and cohort studies have also shown significant familial aggregation of CLL and related conditions including non-Hodgkin and Hodgkin lymphoma. Monoclonal B-cell lymphocytosis also aggregates in families with CLL. However, the clinical implication of familial aggregation is minimal given the overall rarity of CLL. Linkage studies have been conducted in high-risk CLL families to screen the whole genome for loci that contribute to susceptibility, but no gene mutations have yet been identified by this method. Association studies of candidate genes have implicated immune function and other genes, but more studies are needed to verify these findings. The ability to conduct large-scale genomic studies will play an important role in detecting susceptibility genes for CLL over the next few years and thereby help to delineate etiologic pathways. JF - Hematology. American Society of Hematology. Education Program AU - Goldin, Lynn R AU - Slager, Susan L AD - Genetic Epidemiology Branch, DCEG, NCI, 6120 Executive Blvd. Rm 7008, MSC 7236, Bethesda, MD 20892-7236, USA. goldinl@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 339 EP - 345 SN - 1520-4391, 1520-4391 KW - Index Medicus KW - Risk Factors KW - Humans KW - Genetic Predisposition to Disease KW - Leukemia, Lymphocytic, Chronic, B-Cell -- genetics KW - Environmental Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68527340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology.+American+Society+of+Hematology.+Education+Program&rft.atitle=Familial+CLL%3A+genes+and+environment.&rft.au=Goldin%2C+Lynn+R%3BSlager%2C+Susan+L&rft.aulast=Goldin&rft.aufirst=Lynn&rft.date=2007-01-01&rft.volume=&rft.issue=&rft.spage=339&rft.isbn=&rft.btitle=&rft.title=Hematology.+American+Society+of+Hematology.+Education+Program&rft.issn=15204391&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-07-14 N1 - Date created - 2007-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Correlates of "non-problematic" and "problematic" substance use among depressed adolescents in primary care. AN - 68509073; 18018807 AB - Substance use and related problems were assessed in a sample of primary care patients (n = 450) ages 13-21 who screened positive for depression at a clinic visit. Patients were classified as having no substance use (n = 248), non-problematic use (substance use without reported school, work, social, or family problems, n = 90), or use that reportedly caused problems in at least one area (n = 112). In logistic regression models, older age, externalizing symptoms, and not being African American were significantly associated with non-problematic use; older age, male gender, externalizing symptoms, Caucasian/White ethnicity/race, and more friends were associated with problematic use. Odds ratios were similar for patients reporting non-problematic and problematic use, suggesting that, in the presence of depression, any substance use merits evaluation and monitoring to determine treatment needs and to prevent escalation of dysfunction. JF - Journal of addictive diseases AU - Goldstein, Risë B AU - Asarnow, Joan R AU - Jaycox, Lisa H AU - Shoptaw, Steven AU - Murray, Pamela J AD - Department of Psychiatry and Behavioral Science, University of California at Los Angeles, USA. goldster@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 39 EP - 52 VL - 26 IS - 3 SN - 1055-0887, 1055-0887 KW - Index Medicus KW - Acute Disease KW - Severity of Illness Index KW - Humans KW - Health Status KW - Social Behavior KW - Quality of Life -- psychology KW - Demography KW - Adult KW - Surveys and Questionnaires KW - Adolescent KW - Female KW - Male KW - Prevalence KW - Depressive Disorder, Major -- diagnosis KW - Primary Health Care -- utilization KW - Depressive Disorder, Major -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68509073?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+addictive+diseases&rft.atitle=Correlates+of+%22non-problematic%22+and+%22problematic%22+substance+use+among+depressed+adolescents+in+primary+care.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BAsarnow%2C+Joan+R%3BJaycox%2C+Lisa+H%3BShoptaw%2C+Steven%3BMurray%2C+Pamela+J&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2007-01-01&rft.volume=26&rft.issue=3&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Journal+of+addictive+diseases&rft.issn=10550887&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-18 N1 - Date created - 2007-11-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Viral determinants of human papillomavirus persistence following loop electrical excision procedure treatment for cervical intraepithelial neoplasia grade 2 or 3. AN - 68422301; 17220326 AB - Persistent infection with carcinogenic human papillomavirus (HPV) causes cervical precancer (cervical intraepithelial neoplasia grade 2+) which, in the United States, is commonly treated using the loop electrical excision procedure (LEEP). Data from Atypical Squamous Cells of Undetermined Significance-Low-Grade Squamous Intraepithelial Lesion Triage Study were used to evaluate HPV persistence and reappearance after LEEP. Cervical specimens, collected before LEEP and at 6-month study visits, were tested by L1-PCR for detection of >or=27 HPV types. HPV persistence, defined as the same HPV type being present before and 6 months after LEEP, was evaluated by: (a) genotype, (b) carcinogenicity, and (c) phylogenetic species. HPV infections that cleared post-LEEP (the complement of persistence) were followed for reappearance of the same type. HPV infections (n = 1,130) were detected among 481 women who underwent LEEP. Overall, 20.4% [95% confidence interval (95% CI), 18.2-22.9%] of infections persisted. Assessment of heterogeneity within the three categorizations of HPV showed that phylogenetic species best fit the data. Persistence was significantly greater by HPV types in the alpha3 species [all are noncarcinogenic; 40.9% (95% CI, 31.8-50.4%)] compared with HPV types in the alpha9 (HPV16 and related types) and alpha7 species (HPV18 and related types; 17.6% and 17.9%, respectively; P < 0.001 for both). HPV reappeared in 7.8% (95% CI, 6.1-9.9%) of infections that cleared after LEEP. Infections in the alpha3 species (22.6%) were the most likely to reappear compared with HPV types in the alpha9 (7.5%) and alpha7 (6.8%) species. Patterns of HPV persistence and reappearance following LEEP were better explained by phylogenetic rather than standard classifications. HPV types likely to persist after LEEP as well as those likely to repopulate the cervical/vaginal epithelium were those in the alpha3 species, which are in effect not treated, but are not associated with cervical cancer and are unlikely to cause disease. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Kreimer, Aimée R AU - Katki, Hormuzd A AU - Schiffman, Mark AU - Wheeler, Cosette M AU - Castle, Philip E AU - ASCUS-LSIL Triage Study Group AD - Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. kreimera@mail.nih.gov ; ASCUS-LSIL Triage Study Group Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 11 EP - 16 VL - 16 IS - 1 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Risk Factors KW - Humans KW - Predictive Value of Tests KW - Follow-Up Studies KW - United States -- epidemiology KW - Female KW - Papillomavirus Infections -- virology KW - Precancerous Conditions -- surgery KW - Uterine Cervical Neoplasms -- surgery KW - Precancerous Conditions -- epidemiology KW - Precancerous Conditions -- virology KW - Papillomavirus Infections -- epidemiology KW - Cervical Intraepithelial Neoplasia -- surgery KW - Uterine Cervical Neoplasms -- epidemiology KW - Papillomaviridae -- isolation & purification KW - Cervical Intraepithelial Neoplasia -- virology KW - Electrosurgery KW - Papillomavirus Infections -- surgery KW - Uterine Cervical Neoplasms -- virology KW - Cervical Intraepithelial Neoplasia -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68422301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Viral+determinants+of+human+papillomavirus+persistence+following+loop+electrical+excision+procedure+treatment+for+cervical+intraepithelial+neoplasia+grade+2+or+3.&rft.au=Kreimer%2C+Aim%C3%A9e+R%3BKatki%2C+Hormuzd+A%3BSchiffman%2C+Mark%3BWheeler%2C+Cosette+M%3BCastle%2C+Philip+E%3BASCUS-LSIL+Triage+Study+Group&rft.aulast=Kreimer&rft.aufirst=Aim%C3%A9e&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2007-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aerosolized red-tide toxins (brevetoxins) and asthma. AN - 68421030; 17218574 AB - With the increasing incidence of asthma, there is increasing concern over environmental exposures that may trigger asthma exacerbations. Blooms of the marine microalgae, Karenia brevis, cause red tides (or harmful algal blooms) annually throughout the Gulf of Mexico. K brevis produces highly potent natural polyether toxins, called brevetoxins, which are sodium channel blockers, and possibly histamine activators. In experimental animals, brevetoxins cause significant bronchoconstriction. In humans, a significant increase in self-reported respiratory symptoms has been described after recreational and occupational exposures to Florida red-tide aerosols, particularly among individuals with asthma. Before and after 1 h spent on beaches with and without an active K brevis red-tide exposure, 97 persons >or= 12 years of age with physician-diagnosed asthma were evaluated by questionnaire and spirometry. Concomitant environmental monitoring, water and air sampling, and personal monitoring for brevetoxins were performed. Participants were significantly more likely to report respiratory symptoms after K brevis red-tide aerosol exposure than before exposure. Participants demonstrated small, but statistically significant, decreases in FEV(1), midexpiratory phase of forced expiratory flow, and peak expiratory flow after exposure, particularly among those participants regularly using asthma medications. No significant differences were detected when there was no Florida red tide (ie, during nonexposure periods). This study demonstrated objectively measurable adverse changes in lung function from exposure to aerosolized Florida red-tide toxins in asthmatic subjects, particularly among those requiring regular therapy with asthma medications. Future studies will assess these susceptible subpopulations in more depth, as well as the possible long-term effects of these toxins. JF - Chest AU - Fleming, Lora E AU - Kirkpatrick, Barbara AU - Backer, Lorraine C AU - Bean, Judy A AU - Wanner, Adam AU - Reich, Andrew AU - Zaias, Julia AU - Cheng, Yung Sung AU - Pierce, Richard AU - Naar, Jerome AU - Abraham, William M AU - Baden, Daniel G AD - National Institute of Environmental Health Sciences Marine and Freshwater Biomedical Sciences Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL, USA. lfleming@med.miami.edu Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 187 EP - 194 VL - 131 IS - 1 SN - 0012-3692, 0012-3692 KW - Aerosols KW - 0 KW - Marine Toxins KW - Oxocins KW - brevetoxin KW - 98225-48-0 KW - Abridged Index Medicus KW - Index Medicus KW - Respiratory Function Tests KW - Mass Spectrometry KW - Animals KW - Humans KW - Aged KW - Child KW - Florida KW - Chromatography, High Pressure Liquid KW - Environmental Monitoring KW - Inhalation Exposure KW - Adult KW - Surveys and Questionnaires KW - Enzyme-Linked Immunosorbent Assay KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Asthma -- etiology KW - Dinoflagellida -- pathogenicity KW - Oxocins -- toxicity KW - Marine Toxins -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68421030?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chest&rft.atitle=Aerosolized+red-tide+toxins+%28brevetoxins%29+and+asthma.&rft.au=Fleming%2C+Lora+E%3BKirkpatrick%2C+Barbara%3BBacker%2C+Lorraine+C%3BBean%2C+Judy+A%3BWanner%2C+Adam%3BReich%2C+Andrew%3BZaias%2C+Julia%3BCheng%2C+Yung+Sung%3BPierce%2C+Richard%3BNaar%2C+Jerome%3BAbraham%2C+William+M%3BBaden%2C+Daniel+G&rft.aulast=Fleming&rft.aufirst=Lora&rft.date=2007-01-01&rft.volume=131&rft.issue=1&rft.spage=187&rft.isbn=&rft.btitle=&rft.title=Chest&rft.issn=00123692&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-01-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicon. 2000 Jul;38(7):981-93 [10728835] J Allergy Clin Immunol. 2005 Feb;115(2):213-9; quiz 220 [15696070] Environ Toxicol Chem. 2001 Jan;20(1):107-14 [11351396] Environ Health Perspect. 2002 Feb;110(2):179-85 [11836147] Respiration. 2002;69(1):38-45 [11844961] Environ Res. 2002 May;89(1):29-37 [12051782] Bull Environ Contam Toxicol. 2003 Jan;70(1):161-5 [12478439] Cell Mol Neurobiol. 2004 Aug;24(4):553-63 [15233378] JFMA. 1973 Nov;60(11):27-9 [4755462] J Allergy Clin Immunol. 1982 May;69(5):418-28 [7200498] Am J Public Health. 1991 Apr;81(4):471-4 [2003627] Am J Respir Crit Care Med. 1995 Sep;152(3):1107-36 [7663792] Annu Rev Public Health. 2005;26:89-113 [15760282] J Allergy Clin Immunol. 2005 Apr;115(4):689-99 [15805986] Environ Health Perspect. 2005 May;113(5):618-20 [15866773] Environ Health Perspect. 2005 May;113(5):626-31 [15866775] Environ Health Perspect. 2005 May;113(5):632-7 [15866776] Environ Health Perspect. 2005 May;113(5):638-43 [15866777] Environ Health Perspect. 2005 May;113(5):644-9 [15866778] Environ Health Perspect. 2005 May;113(5):650-7 [15866779] Environ Sci Technol. 2005 May 15;39(10):3443-9 [15954221] Am J Ind Med. 1997 Jun;31(6):671-7 [9131220] Child Care Health Dev. 2004 Nov;30(6):711-28 [15527481] Am J Respir Crit Care Med. 2005 Jan 1;171(1):26-34 [15447946] Int J Tuberc Lung Dis. 2000 Jul;4(7):633-8 [10907766] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variant in sex hormone-binding globulin gene and the risk of prostate cancer. AN - 68420372; 17220347 AB - Sex hormones have been implicated in prostate carcinogenesis and are thought to modulate cell proliferation and growth. To investigate the association between polymorphisms in hormone-related genes and prostate cancer risk, we conducted a two-stage, case-control study within the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Using DNA extracted from blood specimens, we initially genotyped 14 single nucleotide polymorphisms in genes involved in hormone regulation or metabolism (AKR1C3, CYP1A1, CYP1B1, CYP3A4, ESR1, GNRH1, HSD173B, HSD3B2, SHBG, and SRD5A2) in 488 prostate cancer cases and 617 matched controls. Heterozygotes at SHBG D356N were found to be associated with an increased risk of prostate cancer compared with the homozygous wild type, particularly among non-Hispanic whites (odds ratio, 1.54; 95% confidence interval, 1.13-2.09; P = 0.006). No significant associations were observed with the other polymorphisms. The SHBG D356N polymorphism, which has potential functional significance, was subsequently genotyped in additional 769 cases and 1,168 controls. Overall, SHBG D356N heterozygotes were found to have an increased risk of prostate cancer among whites (odds ratio, 1.34; 95% confidence interval, 1.10-1.63; P = 0.0007). This study suggests that genetic variation in SHBG may influence prostate cancer susceptibility. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Berndt, Sonja I AU - Chatterjee, Nilanjan AU - Huang, Wen-Yi AU - Chanock, Stephen J AU - Welch, Robert AU - Crawford, E David AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892-7240, USA. berndts@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 165 EP - 168 VL - 16 IS - 1 SN - 1055-9965, 1055-9965 KW - Androgen-Binding Protein KW - 0 KW - Sex Hormone-Binding Globulin KW - Index Medicus KW - Genotype KW - Odds Ratio KW - Risk Factors KW - Humans KW - Case-Control Studies KW - Androgen-Binding Protein -- genetics KW - Male KW - Prostatic Neoplasms -- epidemiology KW - Polymorphism, Genetic KW - Prostatic Neoplasms -- genetics KW - Sex Hormone-Binding Globulin -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68420372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Variant+in+sex+hormone-binding+globulin+gene+and+the+risk+of+prostate+cancer.&rft.au=Berndt%2C+Sonja+I%3BChatterjee%2C+Nilanjan%3BHuang%2C+Wen-Yi%3BChanock%2C+Stephen+J%3BWelch%2C+Robert%3BCrawford%2C+E+David%3BHayes%2C+Richard+B&rft.aulast=Berndt&rft.aufirst=Sonja&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=165&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-29 N1 - Date created - 2007-01-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxin treatment of cancer. AN - 68418807; 17059365 AB - Immunotoxins are proteins used to treat cancer that are composed of an antibody fragment linked to a toxin. The immunotoxin binds to a surface antigen on a cancer cell, enters the cell by endocytosis, and kills it. The most potent immunotoxins are made from bacterial and plant toxins. Refinements over many years have produced recombinant immunotoxins; these therapeutic proteins are made using protein engineering. Individual immunotoxins are designed to treat specific cancers. To date, most success has been achieved treating hematologic tumors. Obstacles to successful treatment of solid tumors include poor penetration into tumor masses and the immune response to the toxin component of the immunotoxin, which limits the number of cycles that can be given. Strategies to overcome these limitations are being pursued. JF - Annual review of medicine AU - Pastan, Ira AU - Hassan, Raffit AU - FitzGerald, David J AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. pastani@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 221 EP - 237 VL - 58 SN - 0066-4219, 0066-4219 KW - Antigens, CD KW - 0 KW - Immunologic Factors KW - Immunotoxins KW - Receptors, Cytokine KW - Toxins, Biological KW - Index Medicus KW - Humans KW - Drug Design KW - Antigens, CD -- immunology KW - Receptors, Cytokine -- immunology KW - Neoplasms -- drug therapy KW - Immunologic Factors -- therapeutic use KW - Immunologic Factors -- pharmacology KW - Immunotoxins -- therapeutic use KW - Immunotoxins -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68418807?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+review+of+medicine&rft.atitle=Immunotoxin+treatment+of+cancer.&rft.au=Pastan%2C+Ira%3BHassan%2C+Raffit%3BFitzGerald%2C+David+J%3BKreitman%2C+Robert+J&rft.aulast=Pastan&rft.aufirst=Ira&rft.date=2007-01-01&rft.volume=58&rft.issue=&rft.spage=221&rft.isbn=&rft.btitle=&rft.title=Annual+review+of+medicine&rft.issn=00664219&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-03 N1 - Date created - 2007-02-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines. AN - 68412532; 17052796 AB - Selenium is an essential nutrient, a component of several anti-oxidant enzymes, and a possible factor in cancer risk, including lung cancer. We determined the subtoxic range of selenium concentration (as sodium selenite) required to increase and maintain the expression of anti-oxidant selenoproteins gluthathione peroxidases GPX1 and GPX4 at a constant level in cultures of human lung adenocarcinoma cell lines (H460, H1703 and H1944) and in HPL1D, a non-transformed lung epithelial cell line. Selenium dose-dependently increased GPX1 protein expression 1.8-fold in HPL1D cells and approximately 40-fold in H460 and H1944 cancer cells, with maximum effects at 20-40 nM. GPX4 protein was also increased, but more so in HPL1D (five-fold) than in H460 or H1944 cells (two- to three-fold). GPX1 mRNA showed similar patterns but differences of lesser magnitude. GPX1 protein and activity level was not consistently detectable in H1703 cells, with or without Se supplementation; its mRNA was present but very low. GPX4 protein level was also low in H1703 cells, but was markedly increased by selenium supplementation (48-fold). These results confirm a role for selenium in risk of lung cancer and the independent regulation of GPX1 and GPX4. Characterization of individual tumors with regard to GPX1 and GPX4 levels and regulation might be useful for interpretation of clinical studies on effects of selenium in lung cancer risk. JF - Lung cancer (Amsterdam, Netherlands) AU - Romanowska, Malgorzata AU - Kikawa, Keith D AU - Fields, Janet R AU - Maciag, Anna AU - North, S Lynn AU - Shiao, Yih-Horng AU - Kasprzak, Kazimierz S AU - Anderson, Lucy M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Building 538, Ft. Detrick, Frederick, MD 21702, USA. mromanowska@ncifcrf.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 35 EP - 42 VL - 55 IS - 1 SN - 0169-5002, 0169-5002 KW - RNA, Messenger KW - 0 KW - glutathione peroxidase GPX1 KW - EC 1.11.1.- KW - phospholipid-hydroperoxide glutathione peroxidase KW - EC 1.11.1.12 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Selenium KW - H6241UJ22B KW - Index Medicus KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - Cell Line, Tumor KW - RNA, Messenger -- genetics KW - Adenocarcinoma -- enzymology KW - Lung Neoplasms -- enzymology KW - Selenium -- pharmacology KW - Glutathione Peroxidase -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68412532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.atitle=Effects+of+selenium+supplementation+on+expression+of+glutathione+peroxidase+isoforms+in+cultured+human+lung+adenocarcinoma+cell+lines.&rft.au=Romanowska%2C+Malgorzata%3BKikawa%2C+Keith+D%3BFields%2C+Janet+R%3BMaciag%2C+Anna%3BNorth%2C+S+Lynn%3BShiao%2C+Yih-Horng%3BKasprzak%2C+Kazimierz+S%3BAnderson%2C+Lucy+M&rft.aulast=Romanowska&rft.aufirst=Malgorzata&rft.date=2007-01-01&rft.volume=55&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Lung+cancer+%28Amsterdam%2C+Netherlands%29&rft.issn=01695002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2007-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Constitutive endocytosis of the metabotropic glutamate receptor mGluR7 is clathrin-independent. AN - 68410921; 16890965 AB - Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors (GPCRs) that are widely expressed throughout the brain and are involved in synaptic development, transmission, and plasticity. The endocytosis of several members of the GPCR superfamily of receptors, such as beta-adrenergic receptors, has been studied extensively. In contrast, the mechanisms regulating mGluR endocytosis and intracellular trafficking remain poorly defined. We describe here for the first time a distinct endocytic and intracellular sorting pathway utilized by mGluR7. We show that mGluR7 constitutively internalizes via a non-clathrin mediated pathway in heterologous cells and in neurons. Unlike clathrin-mediated NMDAR endocytosis, mGluR7 traffics via an Arf6-positive endosomal pathway, similar to other well-characterized proteins such as major histocompatibility complex class I (MHC I) and the GPI-anchored protein CD59. Thus constitutive endocytosis of mGluR7 in neurons is not regulated by clathrin-dependent mechanisms, and this clathrin-independent pathway ultimately determines the amount of receptor present on the plasma membrane available to bind and respond to glutamate. JF - Neuropharmacology AU - Lavezzari, Gabriela AU - Roche, Katherine W AD - National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 35, Room 2C903, Bethesda, MD 20892, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 100 EP - 107 VL - 52 IS - 1 SN - 0028-3908, 0028-3908 KW - Antigens, CD95 KW - 0 KW - Clathrin KW - Histocompatibility Antigens Class I KW - Receptors, Metabotropic Glutamate KW - Transferrin KW - metabotropic glutamate receptor 7 KW - Sucrose KW - 57-50-1 KW - ADP-Ribosylation Factors KW - EC 3.6.5.2 KW - ADP-ribosylation factor 6 KW - Index Medicus KW - Animals KW - Histocompatibility Antigens Class I -- metabolism KW - Fluorescent Antibody Technique -- methods KW - Humans KW - Mutagenesis -- physiology KW - Endosomes KW - Transferrin -- metabolism KW - Rats KW - Transfection -- methods KW - Antigens, CD95 -- metabolism KW - Rats, Sprague-Dawley KW - Cells, Cultured KW - Sucrose -- pharmacology KW - Embryo, Mammalian KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Endocytosis -- genetics KW - Clathrin -- physiology KW - Receptors, Metabotropic Glutamate -- metabolism KW - Hippocampus -- cytology KW - Endocytosis -- drug effects KW - Endocytosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68410921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=Constitutive+endocytosis+of+the+metabotropic+glutamate+receptor+mGluR7+is+clathrin-independent.&rft.au=Lavezzari%2C+Gabriela%3BRoche%2C+Katherine+W&rft.aulast=Lavezzari&rft.aufirst=Gabriela&rft.date=2007-01-01&rft.volume=52&rft.issue=1&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-02 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multivitamin and multimineral dietary supplements: definitions, characterization, bioavailability, and drug interactions. AN - 68409018; 17209208 AB - Although multivitamins, multiminerals, and similar terms (eg, multis or multiples) are commonly used, they have no standard scientific, regulatory, or marketplace definitions. Thus, multivitamins-multiminerals refers to products with widely varied compositions and characteristics. Multivitamin-multimineral composition databases use label values as surrogates for analyzed values. However, actual vitamin and mineral amounts often deviate from label values. Vitamin and mineral bioavailability for dietary supplements also lacks a standard scientific and regulatory definition and validated in vitro and animal models that accurately reflect human bioavailabilities. Systematic information on the bioavailability and bioequivalence of vitamins and minerals in marketed products and on potential drug interactions is scarce. Because of limited information on product characteristics, our ability to directly compare results across studies, estimate changes in usage patterns or intakes over time, and generalize from published results to marketed products is problematic. JF - The American journal of clinical nutrition AU - Yetley, Elizabeth A AD - Office of Dietary Supplements, National Institutes of Health, Bethesda, MD 20892-7517, USA. yetleye@od.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 269S EP - 276S VL - 85 IS - 1 SN - 0002-9165, 0002-9165 KW - Minerals KW - 0 KW - Vitamins KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Primary Prevention KW - Consumer Product Safety KW - Risk Factors KW - Humans KW - Legislation, Drug KW - Biological Availability KW - Vitamins -- pharmacokinetics KW - Minerals -- pharmacokinetics KW - Drug Interactions KW - Dietary Supplements -- statistics & numerical data KW - Chronic Disease -- prevention & control KW - Vitamins -- adverse effects KW - Minerals -- administration & dosage KW - Dietary Supplements -- utilization KW - Vitamins -- administration & dosage KW - Minerals -- adverse effects KW - Dietary Supplements -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68409018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Multivitamin+and+multimineral+dietary+supplements%3A+definitions%2C+characterization%2C+bioavailability%2C+and+drug+interactions.&rft.au=Yetley%2C+Elizabeth+A&rft.aulast=Yetley&rft.aufirst=Elizabeth&rft.date=2007-01-01&rft.volume=85&rft.issue=1&rft.spage=269S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clinical trials of vitamin and mineral supplements for cancer prevention. AN - 68408730; 17209217 AB - Approximately 20-30% of Americans consume multivitamin supplements daily, indicating high public interest in the prevention of cancer and other chronic diseases through a nutrition-based approach. Although several bioactive food components, including vitamins and minerals, have been investigated for their ability to affect cancer risk, few large, randomized, placebo-controlled clinical trials of multivitamins with cancer as the primary endpoint have been performed. The results of most large-scale trials of multivitamin supplements (combinations of > or = 2 vitamins and minerals) to prevent cancer have been mixed. The Linxian General Population and Dysplasia trials found a decreased risk of cancer, particularly stomach cancer, for participants taking a multivitamin supplement, but this was in a borderline-deficient population in China. Two trials, the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study and the beta-Carotene and Retinol Efficacy Trial, found an increased risk of lung cancer among male cigarette smokers or asbestos-exposed persons taking beta-carotene-a surprising result, considering that most epidemiologic studies have suggested that consumption of fruit and vegetables appears to lower cancer risk. To clarify the effects of multivitamin supplements, several large randomized clinical trials are underway, including the Physicians' Health Study II, the Selenium and Vitamin E Cancer Prevention Trial, and a European study, Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI. MAX). Because epidemiologic studies generally evaluate foods rather than specific bioactive food components, a systematic approach to determining how combinations of vitamins and minerals may interact to ameliorate cancer risk is necessary to further our understanding of the potential benefits and risks of supplement use. JF - The American journal of clinical nutrition AU - Greenwald, Peter AU - Anderson, Darrell AU - Nelson, Stefanie A AU - Taylor, Philip R AD - Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7309, USA. pg37g@nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 314S EP - 317S VL - 85 IS - 1 SN - 0002-9165, 0002-9165 KW - Minerals KW - 0 KW - Vitamins KW - Abridged Index Medicus KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Evidence-Based Medicine KW - Humans KW - Dietary Supplements KW - Risk Assessment KW - Vitamins -- adverse effects KW - Minerals -- administration & dosage KW - Vitamins -- administration & dosage KW - Minerals -- adverse effects KW - Neoplasms -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68408730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Clinical+trials+of+vitamin+and+mineral+supplements+for+cancer+prevention.&rft.au=Greenwald%2C+Peter%3BAnderson%2C+Darrell%3BNelson%2C+Stefanie+A%3BTaylor%2C+Philip+R&rft.aulast=Greenwald&rft.aufirst=Peter&rft.date=2007-01-01&rft.volume=85&rft.issue=1&rft.spage=314S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - National Institutes of Health State-of-the-Science Conference Statement: multivitamin/mineral supplements and chronic disease prevention. AN - 68408603; 17209206 JF - The American journal of clinical nutrition AU - National Institutes of Health State-of-the-Science Panel AD - National Institutes of Health State-of-the-Science Panel Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 257S EP - 264S VL - 85 IS - 1 SN - 0002-9165, 0002-9165 KW - Minerals KW - 0 KW - Vitamins KW - Abridged Index Medicus KW - Index Medicus KW - United States KW - Evidence-Based Medicine KW - Primary Prevention KW - Risk Factors KW - Humans KW - Dietary Supplements -- statistics & numerical data KW - Chronic Disease -- prevention & control KW - Vitamins -- adverse effects KW - Minerals -- administration & dosage KW - Dietary Supplements -- utilization KW - Vitamins -- administration & dosage KW - Minerals -- adverse effects KW - Dietary Supplements -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68408603?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=National+Institutes+of+Health+State-of-the-Science+Conference+Statement%3A+multivitamin%2Fmineral+supplements+and+chronic+disease+prevention.&rft.au=National+Institutes+of+Health+State-of-the-Science+Panel&rft.aulast=National+Institutes+of+Health+State-of-the-Science+Panel&rft.aufirst=&rft.date=2007-01-01&rft.volume=85&rft.issue=1&rft.spage=257S&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - PET [11C]DASB imaging of serotonin transporters in patients with alcoholism. AN - 68408566; 17207098 AB - Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were classified as aggressive or nonaggressive based on a comparison between the top third and bottom third scores on the Buss-Durkee Hostility Index. Using a pixel-wise comparison, no brain region showed significant alterations in SERT binding among the 3 groups of subjects (aggressive alcoholic subjects, nonaggressive alcoholic subjects, and healthy controls) or between the combined alcoholic group and healthy controls. None of the clinical measures (including measures of aggression) correlated with SERT binding in the alcoholic subjects. Contrary to prior imaging reports using the nonselective ligand [(123)I]beta-CIT, we found no significant alterations of SERT density in alcoholic patients. JF - Alcoholism, clinical and experimental research AU - Brown, Amira K AU - George, David T AU - Fujita, Masahiro AU - Liow, Jeih-San AU - Ichise, Masanori AU - Hibbeln, Joseph AU - Ghose, Subroto AU - Sangare, Janet AU - Hommer, Daniel AU - Innis, Robert B AD - Molecular Imaging Branch, National Institute of Mental Health, One Center Drive, Bethesda, MD 20892, USA. amirabrown@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 28 EP - 32 VL - 31 IS - 1 SN - 0145-6008, 0145-6008 KW - 3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile KW - 0 KW - Aniline Compounds KW - Radiopharmaceuticals KW - Serotonin Plasma Membrane Transport Proteins KW - Sulfides KW - Index Medicus KW - Neocortex -- metabolism KW - Genotype KW - Brain Mapping KW - Psychiatric Status Rating Scales KW - Positron-Emission Tomography KW - Aggression -- psychology KW - Humans KW - Adult KW - Smoking -- metabolism KW - Data Interpretation, Statistical KW - Neocortex -- diagnostic imaging KW - Image Processing, Computer-Assisted KW - Male KW - Female KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Alcoholism -- diagnostic imaging KW - Alcoholism -- metabolism KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68408566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=PET+%5B11C%5DDASB+imaging+of+serotonin+transporters+in+patients+with+alcoholism.&rft.au=Brown%2C+Amira+K%3BGeorge%2C+David+T%3BFujita%2C+Masahiro%3BLiow%2C+Jeih-San%3BIchise%2C+Masanori%3BHibbeln%2C+Joseph%3BGhose%2C+Subroto%3BSangare%2C+Janet%3BHommer%2C+Daniel%3BInnis%2C+Robert+B&rft.aulast=Brown&rft.aufirst=Amira&rft.date=2007-01-01&rft.volume=31&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Impact of age at first drink on stress-reactive drinking. AN - 68408464; 17207104 AB - Although recent data from animal models indicate that adolescent ethanol exposure increases self-administered ethanol intake in adult rats, the impact of age at first drink on the association between stress and drinking has not been studied in humans. Data collected in the 2001 to 2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were used to estimate the extent to which age at first drink modified the association between stress and average daily volume (ADV) of ethanol intake in a sample of 26,946 past-year drinkers. Successive models estimated the magnitude and significance of the interaction between age at first drink (ages 14 or younger, 15-17, and 18 or older) and number of stressors (out of 12 past-year negative life events) after (1) adjusting for sociodemographic characteristics, (2) additionally adjusting for family history of alcoholism, comorbid psychopathology, adolescent, and past-year tobacco and illicit drug use, and (3) additionally adjusting for all other significant interactions with number of stressors. Even after adjusting for a wide range of confounders and their interactions with stress, initiation of drinking at ages 14 and younger increased the association between the number of stressors and ADV of ethanol consumption by 8% (p=0.014), when considering the full range of 12 potential stressors. In fact, the positive association between stress and consumption was significant only for this group of drinkers with early adolescent exposure to ethanol. Within this group, ADV of consumption increased by an average of 7% with each additional stressor experienced, although the exact percentage increase varied as a function of other covariates that had significant interactions with stress. When a reduced set of 4 stressors was considered, the magnitudes of the associations were mostly unchanged, but the modifying effect of age at first drink fell short of statistical significance (p=0.309) in the fully adjusted model. The findings of this study are consistent with the argument that early-onset drinking may increase stress-reactive ethanol consumption; however, these findings need to be replicated in an experimental human study in order to control fully the direction of the relationship between stress and consumption. JF - Alcoholism, clinical and experimental research AU - Dawson, Deborah A AU - Grant, Bridget F AU - Li, Ting-Kai AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 5635 Fishers Lane MSC 9304, Bethesda, MD 20892, USA. ddawson@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 69 EP - 77 VL - 31 IS - 1 SN - 0145-6008, 0145-6008 KW - Index Medicus KW - Age of Onset KW - Tobacco Use Disorder -- epidemiology KW - Humans KW - Diagnosis, Dual (Psychiatry) KW - Aged KW - Mental Disorders -- psychology KW - Substance-Related Disorders -- psychology KW - Alcoholism -- genetics KW - Smoking -- epidemiology KW - Psychiatric Status Rating Scales KW - Aged, 80 and over KW - Adult KW - Tobacco Use Disorder -- psychology KW - Middle Aged KW - Adolescent KW - Mental Disorders -- complications KW - Female KW - Male KW - Substance-Related Disorders -- epidemiology KW - Alcohol Drinking -- psychology KW - Stress, Psychological -- epidemiology KW - Alcohol Drinking -- epidemiology KW - Stress, Psychological -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68408464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Impact+of+age+at+first+drink+on+stress-reactive+drinking.&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BLi%2C+Ting-Kai&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2007-01-01&rft.volume=31&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS/MS. AN - 68407960; 17005416 AB - Lipids are major structural components of biomembranes. Negatively charged species such as phosphatidylinositol, phosphatidylserine, sulfatides, and the zwitterionic phosphatidylethanolamines are major components of the cytoplasmic surface of the cellular membrane lipid bilayer and play a key role in several receptors signaling functions. Lipids are not just involved in metabolic and neurological diseases; negatively charged lipids in particular play crucial roles in physiological events such as signal transduction, receptors, and enzymatic activation, as well as storage and release of therapeutic drugs and toxic chemicals in the body. Due to the importance of their role in signaling, the field of lipidomics has rapidly expanded in recent years. In the present study, direct probing of tissue slices with negative ion mode matrix assisted laser desorption/ionization mass spectrometry was employed to profile the distribution of lipids in the brain. In total, 32 lipid species consisting of phosphatidylethanolamines, phosphatidylglycerol, phosphatidylinositols, phosphatidylserines, and sulfatides were assigned. To confirm the structure of lipid species, MALDI-MS/MS analysis was conducted. Product-ion spectra obtained in negative ion mode allow for the assignment of the head groups and the fatty acid chains for the lipid species. JF - Journal of the American Society for Mass Spectrometry AU - Jackson, Shelley N AU - Wang, Hay-Yan J AU - Woods, Amina S AD - Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 17 EP - 26 VL - 18 IS - 1 SN - 1044-0305, 1044-0305 KW - Glycerophospholipids KW - 0 KW - Sulfoglycosphingolipids KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Cerebellum -- chemistry KW - Male KW - Glycerophospholipids -- chemistry KW - Sulfoglycosphingolipids -- chemistry KW - Brain Chemistry KW - Brain KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68407960?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Society+for+Mass+Spectrometry&rft.atitle=In+situ+structural+characterization+of+glycerophospholipids+and+sulfatides+in+brain+tissue+using+MALDI-MS%2FMS.&rft.au=Jackson%2C+Shelley+N%3BWang%2C+Hay-Yan+J%3BWoods%2C+Amina+S&rft.aulast=Jackson&rft.aufirst=Shelley&rft.date=2007-01-01&rft.volume=18&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Society+for+Mass+Spectrometry&rft.issn=10440305&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-02 N1 - Date created - 2007-01-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Analysis of mouse development with conditional mutagenesis. AN - 68405524; 17203658 AB - Explorations into the molecular embryology of the mouse have played a vital role in our understanding of the basic mechanisms of gene regulation that govern development and disease. In the last 15 years, these mechanisms have been analyzed with vastly greater precision and clarity with the advent of systems that allow the conditional control of gene expression. Typically, this control is achieved by silencing or activating the gene of interest with site-specific DNA recombination or transcriptional transactivation. In this review, I discuss the application of these technologies to mouse development, focusing on recent innovations and experimental designs that specifically aid the study of the mouse embryo. JF - Handbook of experimental pharmacology AU - Lewandoski, M AD - Laboratory of Cancer and Developmental Biology, NCI-Frederick, National Institutes of Health, Frederick, MD 21702-1201, USA. mlewandoski@mail.ncifcrf.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 235 EP - 262 IS - 178 SN - 0171-2004, 0171-2004 KW - Recombinases KW - 0 KW - Index Medicus KW - Animals KW - RNA Interference KW - Mice, Transgenic KW - Gene Targeting KW - Recombinases -- metabolism KW - Mice -- embryology KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68405524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Handbook+of+experimental+pharmacology&rft.atitle=Analysis+of+mouse+development+with+conditional+mutagenesis.&rft.au=Lewandoski%2C+M&rft.aulast=Lewandoski&rft.aufirst=M&rft.date=2007-01-01&rft.volume=&rft.issue=178&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Handbook+of+experimental+pharmacology&rft.issn=01712004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-17 N1 - Date created - 2007-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of the mouse alphaB-crystallin and MKBP/HspB2 promoter activities by shared and gene specific intergenic elements: the importance of context dependency. AN - 68395629; 17939115 AB - The closely linked (863 bp), divergently arranged mouse myotonic dystrophy kinase binding protein (Mkbp)/HspB2 and small heat shock protein (shsp)/alphaB-crystallin genes have different patterns of tissue-specific expression. We showed previously that an intergenic enhancing region (-436/-257 relative to alphaB-crystallin transcription start site) selectively activates the alphaB-crystallin promoter in an orientation-dependent manner (Swamynathan, S.K. and J. Piatigorsky 2002. J. Biol. Chem. 277:49700-6). Here we show that cis-elements alphaBE1 (-420/-396) and alphaBE3 (-320/-300) functionally interact with glucocorticoid receptor (GR) and Sp1, respectively, both in vitro and in vivo. alphaBE1:GR regulates both the HspB2 and alphaB-crystallin promoters, while alphaBE3:Sp1 selectively regulates the alphaB-crystallin promoter, as judged by mutagenesis and co-transfection tests. Enhancer blocking assays indicate that the -836/-622 fragment can act as a negative regulator in transfection tests, raising the possibility that it contributes to the differential expression of the proximal HspB2 promoter and distal alphaB-crystallin promoter. Finally, experiments utilizing transiently transfected cells and transgenic mice show that two conserved E-box elements (-726/-721 and -702/-697) bind nuclear proteins and differentially regulate the HspB2 and alphaB-crystallin promoters in a tissue-specific manner. Taken together, our results indicate that the linked, differentially expressed HspB2 and alphaB-crystallin genes have evolved shared and promoter-preferred cis-control elements within the intergenic sequence. The context-dependency of cis-elements provides multiple opportunities for evolutionary novelty by small sequence changes. JF - The International journal of developmental biology AU - Swamynathan, Shivalingappa K AU - Piatigorsky, Joram AD - Laboratory of Molecular and Developmental Biology, National Eye Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 689 EP - 700 VL - 51 IS - 8 SN - 0214-6282, 0214-6282 KW - HSP27 Heat-Shock Proteins KW - 0 KW - Heat-Shock Proteins KW - Hspb2 protein, mouse KW - Sp1 Transcription Factor KW - Transcription Factors KW - alpha-Crystallin B Chain KW - Index Medicus KW - Animals KW - Chickens KW - Base Sequence KW - Transcription Factors -- metabolism KW - Humans KW - DNA Mutational Analysis KW - Sp1 Transcription Factor -- metabolism KW - Molecular Sequence Data KW - Mice KW - Tissue Distribution KW - K562 Cells KW - Mutagenesis KW - alpha-Crystallin B Chain -- biosynthesis KW - Promoter Regions, Genetic KW - Heat-Shock Proteins -- biosynthesis KW - Gene Expression Regulation KW - alpha-Crystallin B Chain -- genetics KW - Heat-Shock Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68395629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+International+journal+of+developmental+biology&rft.atitle=Regulation+of+the+mouse+alphaB-crystallin+and+MKBP%2FHspB2+promoter+activities+by+shared+and+gene+specific+intergenic+elements%3A+the+importance+of+context+dependency.&rft.au=Swamynathan%2C+Shivalingappa+K%3BPiatigorsky%2C+Joram&rft.aulast=Swamynathan&rft.aufirst=Shivalingappa&rft.date=2007-01-01&rft.volume=51&rft.issue=8&rft.spage=689&rft.isbn=&rft.btitle=&rft.title=The+International+journal+of+developmental+biology&rft.issn=02146282&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-22 N1 - Date created - 2007-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. AN - 68394858; 17180163 AB - Mounting evidence indicates that microglial activation contributes to neuronal damage in neurodegenerative diseases. Recent studies show that in response to certain environmental toxins and endogenous proteins, microglia can enter an overactivated state and release reactive oxygen species (ROS) that cause neurotoxicity. Pattern recognition receptors expressed on the microglial surface seem to be one of the primary, common pathways by which diverse toxin signals are transduced into ROS production. Overactivated microglia can be detected using imaging techniques and therefore this knowledge offers an opportunity not only for early diagnosis but, importantly, for the development of targeted anti-inflammatory therapies that might slow or halt the progression of neurodegenerative disease. JF - Nature reviews. Neuroscience AU - Block, Michelle L AU - Zecca, Luigi AU - Hong, Jau-Shyong AD - Neuropharmacology Section, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Block@niehs.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 57 EP - 69 VL - 8 IS - 1 SN - 1471-003X, 1471-003X KW - Reactive Oxygen Species KW - 0 KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Neurodegenerative Diseases -- genetics KW - Animals KW - Humans KW - Neurodegenerative Diseases -- metabolism KW - Neurodegenerative Diseases -- pathology KW - Microglia -- physiology KW - Neurotoxicity Syndromes -- metabolism KW - Neurotoxicity Syndromes -- genetics KW - Neurotoxicity Syndromes -- pathology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68394858?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Neuroscience&rft.atitle=Microglia-mediated+neurotoxicity%3A+uncovering+the+molecular+mechanisms.&rft.au=Block%2C+Michelle+L%3BZecca%2C+Luigi%3BHong%2C+Jau-Shyong&rft.aulast=Block&rft.aufirst=Michelle&rft.date=2007-01-01&rft.volume=8&rft.issue=1&rft.spage=57&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Neuroscience&rft.issn=1471003X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-06 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pegylated arginine deiminase lowers hepatitis C viral titers and inhibits nitric oxide synthesis. AN - 68393925; 17201887 AB - The arginine-degrading enzyme, arginine deiminase conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw), reduces extracellular arginine, has minimal toxicity, decreases tumor burden and improves liver function in patients with chronic hepatitis C virus infection (HCV) and inoperable hepatocellular carcinoma (HCC). Reduced extracellular arginine inhibits viral replication through unknown mechanisms. It is hypothesized that ADI-SS PEG 20,000 mw reduces HCV viral titers through nitric oxide (NO)-dependent effects. The effects of ADI-SS PEG 20,000 mw (dose, 160 IU/m2; three cycles of four once-weekly i.m. injections) on HCV titers, serum NO and plasma arginine, were evaluated using archived plasma from patients with HCC and HCV and in vitro cell model measurements of HCV replication. ADI-SS PEG 20,000 mw selectively inhibited HCV replication in vitro (IC50 = 0.027 IU/mL). Fifteen HCC/HCV patients completed treatment. The HCV titers were reduced by up to 99% in five out of 10 (50%) HCV-serotype 1b patients (P = 0.0093). These patients also experienced significant improvements in liver function (P = 0.0091). There were concomitant reductions of plasma arginine and serum NO levels. The HCV titer was not reduced in HCV-type 2c patients. Reduction of extracellular arginine by ADI-SS PEG 20,000 mw in HCC patients reduces HCV viral titers and improves liver function, possibly through suppression of NO. JF - Journal of gastroenterology and hepatology AU - Izzo, Francesco AU - Montella, Maurizio AU - Orlando, Antonio Pio AU - Nasti, Guglielmo AU - Beneduce, Gerardo AU - Castello, Giuseppe AU - Cremona, Francesco AU - Ensor, C Mark AU - Holtzberg, Frederick W AU - Bomalaski, John S AU - Clark, Mike A AU - Curley, Steven A AU - Orlando, Raffaele AU - Scordino, Fabrizio AU - Korba, Brent E AD - National Cancer Institute G Pascale Foundation, Naples, Italy. izzo@connect.it Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 86 EP - 91 VL - 22 IS - 1 SN - 0815-9319, 0815-9319 KW - RNA, Viral KW - 0 KW - Polyethylene Glycols KW - 30IQX730WE KW - Nitric Oxide KW - 31C4KY9ESH KW - Arginine KW - 94ZLA3W45F KW - Hydrolases KW - EC 3.- KW - arginine deiminase KW - EC 3.5.3.6 KW - Index Medicus KW - Carcinoma, Hepatocellular -- virology KW - Tomography, Spiral Computed KW - Carcinoma, Hepatocellular -- diagnostic imaging KW - Carcinoma, Hepatocellular -- drug therapy KW - Liver Neoplasms -- drug therapy KW - Humans KW - Adult KW - Liver Neoplasms -- virology KW - Liver Neoplasms -- diagnostic imaging KW - Polyethylene Glycols -- pharmacology KW - Statistics, Nonparametric KW - RNA, Viral -- analysis KW - Hydrolases -- pharmacology KW - Nitric Oxide -- blood KW - Arginine -- blood KW - Nitric Oxide -- biosynthesis KW - Hepacivirus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68393925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Pegylated+arginine+deiminase+lowers+hepatitis+C+viral+titers+and+inhibits+nitric+oxide+synthesis.&rft.au=Izzo%2C+Francesco%3BMontella%2C+Maurizio%3BOrlando%2C+Antonio+Pio%3BNasti%2C+Guglielmo%3BBeneduce%2C+Gerardo%3BCastello%2C+Giuseppe%3BCremona%2C+Francesco%3BEnsor%2C+C+Mark%3BHoltzberg%2C+Frederick+W%3BBomalaski%2C+John+S%3BClark%2C+Mike+A%3BCurley%2C+Steven+A%3BOrlando%2C+Raffaele%3BScordino%2C+Fabrizio%3BKorba%2C+Brent+E&rft.aulast=Izzo&rft.aufirst=Francesco&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=86&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2007-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stimulant-induced enhanced sexual desire as a potential contributing factor in HIV transmission. AN - 68392326; 17202559 AB - Stimulant abuse is associated with an increased risk of contracting human immunodeficiency virus (HIV). Although sharing of contaminated needles is one of the routes by which HIV is spread, noninjection abusers are also at high risk. The authors investigated the effect of the stimulant drug methylphenidate (given intravenously) on sexual desire as a possible contributing factor to risky sexual behavior associated with the contraction of HIV. The effects of intravenous methylphenidate (0.5 mg/kg) on self-reports of sexual desire (rated from 0-10) were evaluated in 39 comparison subjects and 39 cocaine abusers. Intravenous methylphenidate significantly increased self-reports of sexual desire in comparison subjects (1.4 versus 3.7) and cocaine abusers (2.8 versus 4.8). Stimulant-induced enhancement of sexual desire could be one mechanism by which stimulant drugs such as cocaine and methamphetamine increase the risk for HIV transmission even when they are not injected. JF - The American journal of psychiatry AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Fowler, Joanna S AU - Telang, Frank AU - Jayne, Millard AU - Wong, Christopher AD - National Institute on Drug Abuse, 6001 Executive Blvd., Rm. 5274, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 157 EP - 160 VL - 164 IS - 1 SN - 0002-953X, 0002-953X KW - Central Nervous System Stimulants KW - 0 KW - Placebos KW - Methylphenidate KW - 207ZZ9QZ49 KW - Methamphetamine KW - 44RAL3456C KW - Abridged Index Medicus KW - Index Medicus KW - Administration, Oral KW - Risk-Taking KW - Injections, Intravenous KW - Dose-Response Relationship, Drug KW - Methamphetamine -- adverse effects KW - Humans KW - Adult KW - Methamphetamine -- pharmacology KW - Male KW - Female KW - Comorbidity KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- administration & dosage KW - HIV Infections -- transmission KW - Methylphenidate -- pharmacology KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- epidemiology KW - Central Nervous System Stimulants -- administration & dosage KW - Central Nervous System Stimulants -- adverse effects KW - Cocaine-Related Disorders -- complications KW - Libido -- drug effects KW - Methylphenidate -- adverse effects KW - Sexual Behavior -- psychology KW - HIV Infections -- epidemiology KW - HIV Infections -- psychology KW - Sexual Behavior -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68392326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Stimulant-induced+enhanced+sexual+desire+as+a+potential+contributing+factor+in+HIV+transmission.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BFowler%2C+Joanna+S%3BTelang%2C+Frank%3BJayne%2C+Millard%3BWong%2C+Christopher&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2007-01-01&rft.volume=164&rft.issue=1&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-12 N1 - Date created - 2007-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. AN - 68388065; 17200346 AB - CLIC4, a member of a family of intracellular chloride channels, is regulated by p53, c-Myc, and tumor necrosis factor-alpha. Regulation by factors involved in cancer pathogenesis, together with the previously shown proapoptotic activity of CLIC4, suggests that the protein may have a tumor suppressor function. To address this possibility, we characterized the expression profile, subcellular localization, and gene integrity of CLIC4 in human cancers and determined the functional consequences of CLIC4 expression in tumor epithelium and stromal cells. CLIC4 expression profiles were analyzed by genomics, proteomics, bioinformatics, and tissue microarrays. CLIC4 expression, as a consequence of crosstalk between stroma and epithelium, was tested in vitro by coculture of breast epithelial tumor cells and normal fibroblasts, and the functional consequences of CLIC4 expression was tested in vivo in xenografts of human breast tumor cell lines reconstituted with CLIC4 or mixed with fibroblasts that overexpress CLIC4 transgenically. In cDNA arrays of matched human normal and tumor tissues, CLIC4 expression was reduced in renal, ovarian, and breast cancers. However, CLIC4 protein levels were variable in tumor lysate arrays. Transcript sequences of CLIC4 from the human expressed sequence tag database and manual sequencing of cDNA from 60 human cancer cell lines (NCI60) failed to reveal deletion or mutations in the CLIC4 gene. On matched tissue arrays, CLIC4 was predominantly nuclear in normal human epithelial tissues but not cancers. With advancing malignant progression, CLIC4 staining became undetectable in tumor cells, but expression increased in stromal cells coincident with up-regulation of alpha-smooth muscle actin, suggesting that CLIC4 is up-regulated in myofibroblasts. Coculture of cancer cells and fibroblasts induced the expression of both CLIC4 and alpha-smooth muscle actin in fibroblasts adjacent to tumor nests. Introduction of CLIC4 or nuclear targeted CLIC4 via adenovirus into human breast cancer xenografts inhibited tumor growth, whereas overexpression of CLIC4 in stromal cells of xenografts enhanced tumor growth. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Suh, Kwang S AU - Crutchley, John M AU - Koochek, Arash AU - Ryscavage, Andrew AU - Bhat, Kiran AU - Tanaka, Takemi AU - Oshima, Akira AU - Fitzgerald, Peter AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2007/01/01/ PY - 2007 DA - 2007 Jan 01 SP - 121 EP - 131 VL - 13 IS - 1 SN - 1078-0432, 1078-0432 KW - Actins KW - 0 KW - CLIC4 protein, human KW - Chloride Channels KW - Proto-Oncogene Proteins c-myc KW - TP53 protein, human KW - Tumor Necrosis Factor-alpha KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Genes, Tumor Suppressor KW - DNA Mutational Analysis KW - Humans KW - Disease Progression KW - Actins -- metabolism KW - Cell Line, Tumor KW - Mice KW - Proto-Oncogene Proteins c-myc -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Fibroblasts -- metabolism KW - Neoplasm Transplantation KW - Epithelium -- metabolism KW - Tumor Necrosis Factor-alpha -- metabolism KW - Gene Expression Regulation, Neoplastic KW - Neoplasms -- pathology KW - Chloride Channels -- metabolism KW - Up-Regulation KW - Chloride Channels -- genetics KW - Neoplasms -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68388065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Reciprocal+modifications+of+CLIC4+in+tumor+epithelium+and+stroma+mark+malignant+progression+of+multiple+human+cancers.&rft.au=Suh%2C+Kwang+S%3BCrutchley%2C+John+M%3BKoochek%2C+Arash%3BRyscavage%2C+Andrew%3BBhat%2C+Kiran%3BTanaka%2C+Takemi%3BOshima%2C+Akira%3BFitzgerald%2C+Peter%3BYuspa%2C+Stuart+H&rft.aulast=Suh&rft.aufirst=Kwang&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-12 N1 - Date created - 2007-01-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Emerging infectious diseases that threaten the blood supply. AN - 68384501; 17198845 AB - Following the devastating effects of blood-transmitted human immunodeficiency virus (HIV), blood establishments have become increasingly vigilant for the emergence or re-emergence of new threats to the safety of the blood supply. Many agents have fulfilled the broad definition of emerging blood-transmitted infections, including West Nile virus (WNV), Trypanosoma cruzi, Plasmodium spp., Babesia spp., parvovirus B19, dengue virus, and the prions that cause variant Creutzfeld-Jacob disease (vCJD). Other agents such as human herpes virus-8 (HHV-8-Kaposi's sarcoma virus) and Borellia (Lyme disease) and, perhaps, avian flu virus, are known to have a viremic phase, but have not yet been proved to be transfusion-transmitted. In the wake of these threats, transfusion services use a variety of donor screening interventions, including serologic assays, nucleic acid assays, and geographic exclusions based on potential exposure. The ultimate safeguard may be a pre-emptive pathogen inactivation strategy that will disrupt all nucleic acid-containing agents (though not prions). Considerable effort and resources have been invested in this arena, but currently no single technique is effective for inactivation of both liquid and cellular blood products and toxicity issues have not been completely resolved. The blood supply is remarkably safe with the risk of major pathogens such as hepatitis C virus (HCV) and HIV now reduced to less than one transmission per 2 to 3 million exposures. However, to approach near-zero infectious disease risk for emerging and re-emerging pathogens, new strategies such as pathogen inactivation or multi-pathogen microarray technology will need to be developed or refined. JF - Seminars in hematology AU - Alter, Harvey J AU - Stramer, Susan L AU - Dodd, Roger Y AD - Infectious Diseases Section and Department of Transfusion Medicine, National Institutes of Health, Bethesda, MD 20892, USA. halter@dtm.cc.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 32 EP - 41 VL - 44 IS - 1 SN - 0037-1963, 0037-1963 KW - Index Medicus KW - Virus Diseases -- blood KW - Risk KW - Virus Diseases -- transmission KW - Parasitic Diseases -- blood KW - Humans KW - Prion Diseases -- transmission KW - Prion Diseases -- blood KW - Parasitic Diseases -- transmission KW - Communicable Diseases, Emerging -- blood KW - Blood Transfusion -- adverse effects KW - Blood Donors -- supply & distribution KW - Communicable Diseases, Emerging -- virology KW - Communicable Diseases, Emerging -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68384501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+hematology&rft.atitle=Emerging+infectious+diseases+that+threaten+the+blood+supply.&rft.au=Alter%2C+Harvey+J%3BStramer%2C+Susan+L%3BDodd%2C+Roger+Y&rft.aulast=Alter&rft.aufirst=Harvey&rft.date=2007-01-01&rft.volume=44&rft.issue=1&rft.spage=32&rft.isbn=&rft.btitle=&rft.title=Seminars+in+hematology&rft.issn=00371963&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-13 N1 - Date created - 2007-01-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling of familial and sporadic interstitial pneumonia. AN - 68384277; 16998095 AB - Idiopathic interstitial pneumonia (IIP) and its familial variants are progressive and largely untreatable disorders with poorly understood molecular mechanisms. Both the genetics and the histologic type of IIP play a role in the etiology and pathogenesis of interstitial lung disease, but transcriptional signatures of these subtypes are unknown. To evaluate gene expression in the lung tissue of patients with usual interstitial pneumonia or nonspecific interstitial pneumonia that was either familial or nonfamilial in origin, and to compare it with gene expression in normal lung parenchyma. We profiled RNA from the lungs of 16 patients with sporadic IIP, 10 with familial IIP, and 9 normal control subjects on a whole human genome oligonucleotide microarray. Significant transcriptional differences exist in familial and sporadic IIPs. The genes distinguishing the genetic subtypes belong to the same functional categories as transcripts that distinguish IIP from normal samples. Relevant categories include chemokines and growth factors and their receptors, complement components, genes associated with cell proliferation and death, and genes in the Wnt pathway. The role of the chemokine CXCL12 in disease pathogenesis was confirmed in the murine bleomycin model of lung injury, with C57BL/6(CXCR4+/-) mice demonstrating significantly less collagen deposition than C57BL/6(CXCR4+/+) mice. Whereas substantial differences exist between familial and sporadic IIPs, we identified only minor gene expression changes between usual interstitial pneumonia and nonspecific interstitial pneumonia. Taken together, our findings indicate that differences in gene expression profiles between familial and sporadic IIPs may provide clues to the etiology and pathogenesis of IIP. JF - American journal of respiratory and critical care medicine AU - Yang, Ivana V AU - Burch, Lauranell H AU - Steele, Mark P AU - Savov, Jordan D AU - Hollingsworth, John W AU - McElvania-Tekippe, Erin AU - Berman, Katherine G AU - Speer, Marcy C AU - Sporn, Thomas A AU - Brown, Kevin K AU - Schwarz, Marvin I AU - Schwartz, David A AD - Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, P.O. Box 12233, MD B3-08, Research Triangle Park, NC 27909, USA. yangi@niehs.nih.gov Y1 - 2007/01/01/ PY - 2007 DA - 2007 Jan 01 SP - 45 EP - 54 VL - 175 IS - 1 SN - 1073-449X, 1073-449X KW - CXCL12 protein, human KW - 0 KW - CXCR4 protein, mouse KW - Chemokine CXCL12 KW - Chemokines, CXC KW - Cxcl12 protein, mouse KW - RNA, Messenger KW - Receptors, CXCR4 KW - Wnt Proteins KW - Bleomycin KW - 11056-06-7 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Chemokines, CXC -- analysis KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Lung -- chemistry KW - Gene Expression KW - Aged KW - Bleomycin -- toxicity KW - Disease Models, Animal KW - Mice KW - Lung -- pathology KW - Pulmonary Fibrosis -- genetics KW - Mice, Knockout KW - Wnt Proteins -- genetics KW - Gene Expression Profiling KW - Pulmonary Fibrosis -- chemically induced KW - Adult KW - Middle Aged KW - Receptors, CXCR4 -- genetics KW - Chemokines, CXC -- genetics KW - Male KW - Female KW - RNA, Messenger -- metabolism KW - Lung Diseases, Interstitial -- metabolism KW - RNA, Messenger -- analysis KW - Lung Diseases, Interstitial -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68384277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+and+critical+care+medicine&rft.atitle=Gene+expression+profiling+of+familial+and+sporadic+interstitial+pneumonia.&rft.au=Yang%2C+Ivana+V%3BBurch%2C+Lauranell+H%3BSteele%2C+Mark+P%3BSavov%2C+Jordan+D%3BHollingsworth%2C+John+W%3BMcElvania-Tekippe%2C+Erin%3BBerman%2C+Katherine+G%3BSpeer%2C+Marcy+C%3BSporn%2C+Thomas+A%3BBrown%2C+Kevin+K%3BSchwarz%2C+Marvin+I%3BSchwartz%2C+David+A&rft.aulast=Yang&rft.aufirst=Ivana&rft.date=2007-01-01&rft.volume=175&rft.issue=1&rft.spage=45&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+and+critical+care+medicine&rft.issn=1073449X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-28 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6292-7 [11983918] Am J Respir Crit Care Med. 2002 May 1;165(9):1322-8 [11991887] Cell Biol Int. 2002;26(5):463-76 [12095232] Am J Respir Cell Mol Biol. 2002 Dec;27(6):705-13 [12444030] Chest. 2002 Dec;122(6 Suppl):334S-339S [12475811] Am J Pathol. 2003 May;162(5):1495-502 [12707032] Am J Respir Cell Mol Biol. 2003 Sep;29(3 Suppl):S32-6 [14503551] J Clin Invest. 2004 Jan;113(2):243-52 [14722616] Am J Respir Crit Care Med. 2000 Dec;162(6):2213-7 [11112140] Am J Respir Crit Care Med. 2001 Nov 1;164(9):1722-7 [11719316] Am J Respir Crit Care Med. 2002 Jan 15;165(2):277-304 [11790668] J Clin Invest. 2004 Jul;114(2):291-9 [15254596] J Clin Invest. 2004 Aug;114(3):438-46 [15286810] Am J Respir Cell Mol Biol. 2004 Oct;31(4):395-404 [15205180] Dis Chest. 1969 Jan;55(1):7-12 [5763753] Chest. 1970 Nov;58(5):538-40 [5507952] Am Rev Respir Dis. 1973 Aug;108(2):193-204 [4198347] Am J Med. 1977 Sep;63(3):475-80 [900150] Ann N Y Acad Sci. 1979;330:295-311 [294180] Ann N Y Acad Sci. 1979;330:333-9 [294185] Chest. 1980 Oct;78(4):591-4 [7191366] N Engl J Med. 1981 Dec 31;305(27):1617-27 [6796886] Medicine (Baltimore). 1985 May;64(3):192-202 [3921802] Clin Exp Immunol. 1985 Oct;62(1):57-64 [4064377] N Engl J Med. 1986 May 22;314(21):1343-7 [3702942] Am Rev Respir Dis. 1987 Feb;135(2):448-55 [2433976] Am J Respir Cell Mol Biol. 1994 Nov;11(5):531-9 [7946383] Exp Lung Res. 1998 Nov-Dec;24(6):721-43 [9839161] Am J Respir Crit Care Med. 1999 Sep;160(3):899-905 [10471616] Am J Pathol. 1954 Mar-Apr;30(2):263-85 [13138710] Thorax. 1964 Nov;19:515-25 [14238389] Am J Med. 1965 Sep;39:411-21 [14338292] Nat Rev Immunol. 2005 Jan;5(1):21-30 [15630426] Chest. 2005 Jan;127(1):275-83 [15653995] Am J Respir Crit Care Med. 2005 Feb 1;171(3):261-8 [15502109] J Med Genet. 2005 Jun;42(6):464-73 [15937080] Am J Respir Cell Mol Biol. 2005 Jul;33(1):9-13 [15964990] PLoS Med. 2005 Sep;2(9):e251 [16128620] Am J Respir Crit Care Med. 2005 Nov 1;172(9):1146-52 [16109978] Am J Pathol. 2005 Dec;167(6):1485-96 [16314464] Am J Respir Crit Care Med. 2006 Jan 15;173(2):188-98 [16166619] J Clin Pathol. 2006 Jan;59(1):28-39 [16394278] Comment In: Am J Respir Crit Care Med. 2008 Mar 1;177(5):558-9 [18296474] Am J Respir Crit Care Med. 2007 Jan 1;175(1):5-6 [17179494] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade. AN - 68382967; 17136498 AB - Apo2L/TRAIL is actively investigated as a novel targeted agent to directly induce apoptosis of susceptible cancer cells. Apo2L/TRAIL-refractory cells can be sensitized to the cytotoxic effect of this ligand by cytotoxic chemotherapeutics. The aim of this study was to evaluate the in vitro tumoricidal activity of the Apo2L/TRAIL + Trichostatin A in cultured thoracic cancer cells and to elucidate the molecular basis of the synergistic cytotoxicity of this combination. Concurrent exposure of cultured cancer cells to sublethal concentrations of Apo2L/TRAIL and Trichostatin A resulted in profound enhancement of Apo2L/TRAIL-mediated cytotoxicity in all cell lines regardless of their intrinsic susceptibility to this ligand. This combination was not toxic to primary normal cells. While Apo2L/TRAIL alone or Trichostatin A alone mediated < 20% cell death, 60 to 90% of cancer cells were apoptotic following treatment with TSA + Apo2L/TRAIL combinations. Complete translocation of Bax from the cytosol to the mitochondria compartment was mainly observed in combination-treated cells and this was correlated with robust elevation of caspase 9 proteolytic activity indicative of activation of the mitochondria apoptogenic effect. Profound TSA + Apo2L/TRAIL-mediated cytotoxicity and apoptosis were completely abrogated by either Bcl2 over-expression or by the selective caspase 9 inhibitor, highlighting the essential role of mitochondria-dependent apoptosis signaling cascade in this process. Moreover, increased caspase 8 activity observed in cells treated with the TSA + Apo2L/TRAIL combination was completely suppressed by Bcl-2 over-expression or by the selective caspase 9 inhibitor indicating that the elevated caspase 8 activity in combination-treated cells was secondary to a mitochondria-mediated amplification feedback loop of caspase activation. These finding form the basis for further development of HDAC inhibitors + Apo2L/TRAIL combination as novel targeted therapy for thoracic malignancies. JF - Apoptosis : an international journal on programmed cell death AU - Reddy, Rishindra M AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Nguyen, Duc M AU - Baras, Aris AU - Ziauddin, M Firdos AU - Shamimi-Noori, Susan M AU - Maxhimer, Justin B AU - Schrump, David S AU - Nguyen, Dao M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 55 EP - 71 VL - 12 IS - 1 SN - 1360-8185, 1360-8185 KW - Enzyme Inhibitors KW - 0 KW - Histone Deacetylase Inhibitors KW - Hydroxamic Acids KW - Recombinant Proteins KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - trichostatin A KW - 3X2S926L3Z KW - Caspases KW - EC 3.4.22.- KW - Index Medicus KW - Enzyme Inhibitors -- administration & dosage KW - Enzyme Activation KW - Humans KW - Mitochondria -- drug effects KW - Mitochondria -- metabolism KW - Cell Line, Tumor KW - Drug Synergism KW - Recombinant Proteins -- administration & dosage KW - Caspases -- metabolism KW - Thoracic Neoplasms -- pathology KW - Hydroxamic Acids -- administration & dosage KW - Thoracic Neoplasms -- drug therapy KW - Apoptosis -- physiology KW - Thoracic Neoplasms -- metabolism KW - TNF-Related Apoptosis-Inducing Ligand -- administration & dosage KW - Apoptosis -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68382967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Apoptosis+%3A+an+international+journal+on+programmed+cell+death&rft.atitle=Rapid+and+profound+potentiation+of+Apo2L%2FTRAIL-mediated+cytotoxicity+and+apoptosis+in+thoracic+cancer+cells+by+the+histone+deacetylase+inhibitor+Trichostatin+A%3A+the+essential+role+of+the+mitochondria-mediated+caspase+activation+cascade.&rft.au=Reddy%2C+Rishindra+M%3BYeow%2C+Wen-Shuz%3BChua%2C+Alex%3BNguyen%2C+Duc+M%3BBaras%2C+Aris%3BZiauddin%2C+M+Firdos%3BShamimi-Noori%2C+Susan+M%3BMaxhimer%2C+Justin+B%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Reddy&rft.aufirst=Rishindra&rft.date=2007-01-01&rft.volume=12&rft.issue=1&rft.spage=55&rft.isbn=&rft.btitle=&rft.title=Apoptosis+%3A+an+international+journal+on+programmed+cell+death&rft.issn=13608185&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tramadol in the treatment of neuropathic cancer pain: a double-blind, placebo-controlled study. AN - 68381949; 17177582 AB - To assess the efficacy, safety and impact on quality of life of tramadol in the treatment of neuropathic pain in patients with cancer. Patients with similar characteristics were grouped in pairs and randomised to receive either tramadol or placebo. The initial tramadol dosage was 1 mg/kg every 6 hours, increasing to 1.5 mg/kg every 6 hours if necessary to control pain. The study enrolled 36 patients (22 women, 14 men), with a mean age of 50 years. In the group receiving tramadol (n = 18), major improvements in pain intensity and Karnofsky scores occurred (p < 0.001), sleep quality improved by day 45 (p < 0.05) activities of daily living improved (p < 0.05), and use of analgesics that had been taken before the study was reduced (p < 0.05) compared with the placebo group. There was no difference between the groups with regard to changes in the Zung Depression Scale, Beck Anxiety Inventory scores and neurophysiological assessments. More patients in the tramadol group experienced adverse events (p < 0.05). The most common adverse events were nausea, vomiting and constipation. Tramadol is a therapeutic option for the control of neuropathic pain in patients with cancer, and appears to improve quality of life in these patients. The analgesic effect of tramadol is independent of changes in anxiety, depression and nervous system function. JF - Clinical drug investigation AU - Arbaiza, Daniel AU - Vidal, Oscar AD - Service of Neuro-Oncology, National Cancer Institute, Lima, Peru. darbaiza@inen.sld.pe Y1 - 2007 PY - 2007 DA - 2007 SP - 75 EP - 83 VL - 27 IS - 1 SN - 1173-2563, 1173-2563 KW - Analgesics, Opioid KW - 0 KW - Tramadol KW - 39J1LGJ30J KW - Index Medicus KW - Administration, Oral KW - Double-Blind Method KW - Humans KW - Vomiting -- chemically induced KW - Patient Dropouts -- statistics & numerical data KW - Quality of Life KW - Activities of Daily Living KW - Constipation -- chemically induced KW - Appetite -- drug effects KW - Nausea -- chemically induced KW - Prospective Studies KW - Sleep -- drug effects KW - Adult KW - Treatment Outcome KW - Analgesics, Opioid -- therapeutic use KW - Middle Aged KW - Analgesics, Opioid -- administration & dosage KW - Analgesics, Opioid -- adverse effects KW - Male KW - Female KW - Karnofsky Performance Status -- statistics & numerical data KW - Neuralgia -- drug therapy KW - Neuralgia -- etiology KW - Neoplasms -- diagnosis KW - Neoplasms -- complications KW - Tramadol -- adverse effects KW - Tramadol -- therapeutic use KW - Tramadol -- administration & dosage KW - Neuralgia -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68381949?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+drug+investigation&rft.atitle=Tramadol+in+the+treatment+of+neuropathic+cancer+pain%3A+a+double-blind%2C+placebo-controlled+study.&rft.au=Arbaiza%2C+Daniel%3BVidal%2C+Oscar&rft.aulast=Arbaiza&rft.aufirst=Daniel&rft.date=2007-01-01&rft.volume=27&rft.issue=1&rft.spage=75&rft.isbn=&rft.btitle=&rft.title=Clinical+drug+investigation&rft.issn=11732563&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-17 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The 2006 Bernard B. Brodie Award Lecture. Cyp2e1. AN - 68381912; 17020953 AB - Bernard B. Brodie's laboratory was the first to examine the mechanisms of drug-induced toxicity at the molecular level. They found that acetaminophen hepatotoxicity was due to the metabolic activation of the drug to a highly reactive toxic metabolite that depleted cellular glutathione and covalently bound to protein. Subsequent studies revealed that activation of acetaminophen to an active metabolite is primarily carried out by CYP2E1, an ethanol-inducible cytochrome P450 that was first suggested by characterization of the microsomal ethanol oxidation system. CYP2E1 is developmentally regulated, under liver-specific control, and undergoes substrate-induced protein stabilization. It is also regulated by starvation and diabetes through insulin-dependent mRNA stabilization. In addition to acetaminophen, CYP2E1 metabolically activates a large number of low M(r) toxicants and carcinogens and thus is of great toxicological importance. The mechanism of regulation CYP2E1 and its role in acetaminophen toxicity will be discussed. JF - Drug metabolism and disposition: the biological fate of chemicals AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Building 37/Room 3106, Bethesda, MD 20892, USA. fjgonz@helix.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 1 EP - 8 VL - 35 IS - 1 SN - 0090-9556, 0090-9556 KW - Analgesics, Non-Narcotic KW - 0 KW - RNA, Messenger KW - Acetaminophen KW - 362O9ITL9D KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Index Medicus KW - Animals KW - Neoplasms -- enzymology KW - Chemical and Drug Induced Liver Injury KW - Humans KW - Acetaminophen -- adverse effects KW - Ethanol -- metabolism KW - Analgesics, Non-Narcotic -- metabolism KW - Liver Diseases, Alcoholic -- enzymology KW - Analgesics, Non-Narcotic -- adverse effects KW - Ethanol -- adverse effects KW - RNA, Messenger -- metabolism KW - Microsomes -- metabolism KW - Acetaminophen -- metabolism KW - Liver Diseases -- enzymology KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Cytochrome P-450 CYP2E1 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68381912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.atitle=The+2006+Bernard+B.+Brodie+Award+Lecture.+Cyp2e1.&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+metabolism+and+disposition%3A+the+biological+fate+of+chemicals&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2006-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene. AN - 68379317; 17187507 AB - The human multidrug resistance gene ATP-binding cassette B1 (ABCB1) codes for P-glycoprotein (P-gp), an important membrane-bound efflux transporter known to confer anticancer drug resistance as well as affect the pharmacokinetics of many drugs and xenobiotics. A number of single nucleotide polymorphisms (SNPs) have been identified throughout the ABCB1 gene that may have an effect on P-gp expression levels and function. Haplotype as well as genotype analysis of SNPs is becoming increasingly important in identifying genetic variants underlying susceptibility to human disease. Three SNPs, 1236C-->T, 2677G-->T and 3435C-->T, have been repeatedly shown to predict changes in the function of P-gp. The frequencies with which these polymorphisms exist in a population have also been shown to be ethnically related. In this study, 95 individuals representative of the entire ethnic make-up of the USA were compared with 101 individuals from an Ashkenazi-Jewish population. These individuals were analyzed by genomic sequencing and polymerase chain reaction, using restriction fragment length polymorphisms, to calculate their genotype frequencies. A total of 25 SNPs were located in the exons of the ABCB1 gene. All of the polymorphisms identified were in parts of the ABCB1 gene product predicted to be intracellular, and 16 appear to be novel as compared with those listed by the National Center for Biotechnological Information. Frequencies of the 1236C-->T and 2677G-->T/A/C SNPs were similar for the US and Ashkenazi populations (64.2 and 60.4%, respectively for 1236C-->T [chi2: 0.30; p T/A/C [chi2: 1.49; p T (24.2% for the US population and 69.3% for the Ashkenazi population [chi2: 39.927; p T plays a significant role in the ABCB1 gene. The haplotype and genotype analysis from these data may be used as a basis for studies on the relationship between ABCB1 genotypes and drug efficacy, drug toxicity, disease susceptibility or other phenotypes. JF - Pharmacogenomics AU - Kimchi-Sarfaty, Chava AU - Marple, Andrew H AU - Shinar, Shiri AU - Kimchi, Avraham M AU - Scavo, David AU - Roma, M Isabella AU - Kim, In-Wha AU - Jones, Adam AU - Arora, Mili AU - Gribar, John AU - Gurwitz, David AU - Gottesman, Michael M AD - National Institutes of Health, Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4254, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 29 EP - 39 VL - 8 IS - 1 KW - ABCB1 protein, human KW - 0 KW - P-Glycoprotein KW - P-Glycoproteins KW - Index Medicus KW - Phenotype KW - Genotype KW - Polymerase Chain Reaction KW - Genes, MDR -- genetics KW - Humans KW - Jews -- genetics KW - Genetic Predisposition to Disease KW - P-Glycoprotein -- physiology KW - Haplotypes -- genetics KW - P-Glycoprotein -- genetics KW - Polymorphism, Single Nucleotide -- genetics KW - Ethnic Groups -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68379317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Ethnicity-related+polymorphisms+and+haplotypes+in+the+human+ABCB1+gene.&rft.au=Kimchi-Sarfaty%2C+Chava%3BMarple%2C+Andrew+H%3BShinar%2C+Shiri%3BKimchi%2C+Avraham+M%3BScavo%2C+David%3BRoma%2C+M+Isabella%3BKim%2C+In-Wha%3BJones%2C+Adam%3BArora%2C+Mili%3BGribar%2C+John%3BGurwitz%2C+David%3BGottesman%2C+Michael+M&rft.aulast=Kimchi-Sarfaty&rft.aufirst=Chava&rft.date=2007-01-01&rft.volume=8&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=1744-8042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2006-12-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenetics. 2004 Jun;14(6):381-5 [15247630] Am J Hum Genet. 2004 Aug;75(2):282-93 [15208782] Genes Immun. 2004 Nov;5(7):530-9 [15505619] Science. 1994 Oct 7;266(5182):107-9 [7524148] Br J Pharmacol. 1996 Nov;119(5):1038-44 [8922756] Biochemistry. 1998 Mar 17;37(11):3594-601 [9530286] Arch Intern Med. 1998 Apr 13;158(7):777-81 [9554684] Science. 2003 Oct 24;302(5645):643-6 [14576434] Pharmacogenetics. 2003 Nov;13(11):675-82 [14583680] Bull Exp Biol Med. 2003 Aug;136(2):183-5 [14631505] Am J Hum Genet. 2003 Dec;73(6):1250-60 [14624392] Am J Hum Genet. 2004 Apr;74(4):623-36 [15024686] Eur J Haematol. 2004 May;72(5):314-21 [15059065] Eur J Hum Genet. 2004 May;12(5):355-64 [14722586] Swiss Med Wkly. 2006 Jun 10;136(23-24):377-82 [16847760] Drug Metab Pharmacokinet. 2006 Jun;21(3):194-200 [16858122] Science. 2007 Jan 26;315(5811):525-8 [17185560] Nature. 1998 May 7;393(6680):79-82 [9590693] N Engl J Med. 2004 Nov 4;351(19):1972-7 [15525722] Ther Drug Monit. 2004 Dec;26(6):679-84 [15570194] Antivir Ther. 2004 Dec;9(6):929-35 [15651752] Br J Clin Pharmacol. 2005 Mar;59(3):365-70 [15752383] Arch Neurol. 2005 Mar;62(3):460-4 [15767512] Epilepsia. 2005 May;46(5):643-7 [15857428] Eur J Clin Pharmacol. 2005 Jul;61(5-6):389-94 [15912392] Biochim Biophys Acta. 2006 Jan;1762(1):17-28 [16297602] Am J Hum Genet. 2006 Mar;78(3):487-97 [16404693] Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8 [10716719] Science. 2001 Feb 16;291(5507):1304-51 [11181995] Br J Pharmacol. 2001 Mar;132(6):1183-92 [11250868] Am J Hum Genet. 2001 Apr;68(4):978-89 [11254454] Pharmacogenetics. 2001 Apr;11(3):217-21 [11337937] J Pharmacol Exp Ther. 2001 Jun;297(3):1137-43 [11356939] Blood. 2001 Jun 1;97(11):3605-11 [11369657] Int J Clin Pharmacol Ther. 2001 Mar;39(3):93-101 [11396754] Clin Pharmacol Ther. 2001 Aug;70(2):189-99 [11503014] Eur J Hum Genet. 2001 Aug;9(8):634-7 [11528510] Annu Rev Med. 2002;53:615-27 [11818492] J Hum Genet. 2002;47(1):38-50 [11829140] Annu Rev Biochem. 2002;71:537-92 [12045106] J Am Soc Nephrol. 2002 Jul;13(7):1847-54 [12089380] Pharmacogenetics. 2002 Aug;12(6):437-50 [12172212] Clin Pharmacol Ther. 2002 Aug;72(2):209-19 [12189368] Transplantation. 2002 Aug 27;74(4):571-2 [12352921] Pharmacogenetics. 2002 Oct;12(7):529-34 [12360103] Biol Pharm Bull. 2002 Oct;25(10):1356-9 [12392094] Pharm Res. 2002 Oct;19(10):1581-5 [12425480] Clin Pharmacol Ther. 2002 Nov;72(5):584-94 [12426522] Annu Rev Pharmacol Toxicol. 2003;43:285-307 [12359865] Oncology. 2003;64(2):183-5 [12566917] N Engl J Med. 2003 Feb 6;348(6):538-49 [12571262] Pharmacogenomics. 2003 Mar;4(2):171-8 [12605551] Pharmacogenetics. 2003 Aug;13(8):481-94 [12893986] Am J Hum Genet. 2003 Nov;73(5):1162-9 [14574645] Oncogene. 2003 Oct 20;22(47):7468-85 [14576852] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin. AN - 68379203; 17158520 AB - In response to DNA damage, cell cycle arrest, apoptosis, and DNA repair are mediated by a TP53 pathway that induces p21(WAF1/Cip1). The chemotherapeutic drug cis-diamminedichloroplatinum-II (cisplatin) damages cellular DNA by forming cis-diammineplatinum-N(7)-d[GpG] and cis-diammine-platinum-N(7)-d[ApG] adducts. To investigate the role of p21, skin keratinocytes from p21(WAF1/Cip1) wild-type (+/+), heterozygous (+/-), and null (-/-) mice, cultured in calcium levels designed to maintain a proliferating state, were exposed to 5 microM cisplatin continuously for 0, 8, 24, 48 and 72 h. At all time points the (+/-) cells had the fewest Pt-DNA adducts, and at 24 h mean Pt-DNA adduct levels were 541, 153 and 779 fmol adduct/mug DNA for p21(WAF1/Cip1) (+/+), (+/-) and (-/-) cells, respectively [P < 0.05 for (+/+) versus (+/-) and (-/-) versus (+/-)]. In order to understand underlying events, we examined p21(WAF1/Cip1) messenger RNA (mRNA), cell cycle arrest, and apoptosis in these cells. At 48 h of cisplatin exposure p21(WAF1/Cip1) mRNA expression was 2-fold higher in the (+/+) cells, compared to the (+/-) cells. At 24 h, the % of cells in S-phase in cisplatin-exposed cultures, compared to unexposed cultures, was decreased by 51, 40 and 11% in p21(WAF1/Cip1) (+/+), (+/-) and (-/-) cells, respectively (P = 0.04, ANOVA). At 24, 48 and 72 h the % of cisplatin-exposed (+/+) cells in apoptosis was 9.4-10.5%, while the cisplatin-exposed (+/-) and (-/-) cells had 1.2-3.7% of cells in apoptosis. The data support the interpretation that DNA replication arrest and apoptosis do not completely explain the low levels of Pt-DNA adducts in the (+/-) cells, and suggest that p21(WAF1/Cip1) controls activity resulting in either low Pt-DNA adduct formation or enhanced Pt-DNA adduct removal. JF - Mutagenesis AU - van Gijssel, Hilde E AU - Leil, Tarek A AU - Weinberg, Wendy C AU - Divi, Rao L AU - Olivero, Ofelia A AU - Poirier, Miriam C AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, CCR, National Cancer Institute, National Institutes of Health, Building 37 Room 4032, Bethesda, MD 20892-4255, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 49 EP - 54 VL - 22 IS - 1 SN - 0267-8357, 0267-8357 KW - Cdkn1a protein, mouse KW - 0 KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA Adducts KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Animals, Newborn KW - Animals KW - Apoptosis -- drug effects KW - Mice KW - Gene Dosage -- physiology KW - Time Factors KW - Gene Dosage -- drug effects KW - DNA Adducts -- metabolism KW - Cell Line KW - Cell Cycle -- drug effects KW - Mice, Knockout KW - Keratinocytes -- drug effects KW - Cisplatin -- toxicity KW - Cyclin-Dependent Kinase Inhibitor p21 -- genetics KW - DNA Damage -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68379203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutagenesis&rft.atitle=Cisplatin-DNA+damage+in+p21WAF1%2FCip1+deficient+mouse+keratinocytes+exposed+to+cisplatin.&rft.au=van+Gijssel%2C+Hilde+E%3BLeil%2C+Tarek+A%3BWeinberg%2C+Wendy+C%3BDivi%2C+Rao+L%3BOlivero%2C+Ofelia+A%3BPoirier%2C+Miriam+C&rft.aulast=van+Gijssel&rft.aufirst=Hilde&rft.date=2007-01-01&rft.volume=22&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Mutagenesis&rft.issn=02678357&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-11 N1 - Date created - 2006-12-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Preconception maternal polychlorinated biphenyl concentrations and the secondary sex ratio. AN - 68377384; 16780830 AB - The secondary sex ratio is the ratio of male to female live births and historically has ranged from 102 to 106 males to 100 females. Temporal declines have been reported in many countries prompting authors to hypothesize an environmental etiology. Blood specimens were obtained from 99 women aged 24-34 prior to attempting pregnancy and quantified for 76 polychlorinated biphenyl (PCB) congeners using dual column gas chromatography with electron capture detection. Women were prospectively followed until pregnancy or 12 cycles of trying. The odds of a male birth for three PCB groupings (total, estrogenic, anti-estrogenic) controlling for maternal characteristics were estimated using logistic regression. Among the 50 women with live births and PCB data, 26 female and 24 male infants were born (ratio 0.92). After adjusting for age and body mass index, odds of a male birth were elevated among women in the second (OR=1.29) and third (OR=1.48) tertiles of estrogenic PCBs; odds (OR=0.70) were reduced among women in the highest tertile of anti-estrogenic PCBs. All confidence intervals included one. The direction of the odds ratios in this preliminary study varied by PCB groupings, supporting the need to study specific PCB patterns when assessing environmental influences on the secondary sex ratio. JF - Environmental research AU - Taylor, Kira C AU - Jackson, Leila W AU - Lynch, Courtney D AU - Kostyniak, Paul J AU - Buck Louis, Germaine M AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Development (NICHD), NIH, DHHS, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 99 EP - 105 VL - 103 IS - 1 SN - 0013-9351, 0013-9351 KW - Environmental Pollutants KW - 0 KW - Estrogens, Non-Steroidal KW - Polychlorinated Biphenyls KW - DFC2HB4I0K KW - Index Medicus KW - New York KW - Humans KW - Adult KW - Estrogens, Non-Steroidal -- blood KW - Male KW - Female KW - Pregnancy KW - Polychlorinated Biphenyls -- blood KW - Sex Ratio KW - Environmental Pollutants -- blood KW - Maternal Exposure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68377384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+research&rft.atitle=Preconception+maternal+polychlorinated+biphenyl+concentrations+and+the+secondary+sex+ratio.&rft.au=Taylor%2C+Kira+C%3BJackson%2C+Leila+W%3BLynch%2C+Courtney+D%3BKostyniak%2C+Paul+J%3BBuck+Louis%2C+Germaine+M&rft.aulast=Taylor&rft.aufirst=Kira&rft.date=2007-01-01&rft.volume=103&rft.issue=1&rft.spage=99&rft.isbn=&rft.btitle=&rft.title=Environmental+research&rft.issn=00139351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-21 N1 - Date created - 2006-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heteromeric nicotinic acetylcholine-dopamine autoreceptor complexes modulate striatal dopamine release. AN - 68377368; 16710311 AB - In the striatum, dopamine and acetylcholine (ACh) modulate dopamine release by acting, respectively, on dopamine D(2) autoreceptors and nicotinic ACh (nACh) heteroreceptors localized on dopaminergic nerve terminals. The possibility that functional interactions exist between striatal D(2) autoreceptors and nACh receptors was studied with in vivo microdialysis in freely moving rats. Local perfusion of nicotine in the ventral striatum (shell of the nucleus accumbens) produced a marked increase in the extracellular levels of dopamine, which was completely counteracted by co-perfusion with either the non-alpha(7) nACh receptor antagonist dihydro-beta-erythroidine or the D(2-3) receptor agonist quinpirole. Local perfusion of the D(2-3) receptor antagonist raclopride produced an increase in the extracellular levels of dopamine, which was partially, but significantly, counteracted by coperfusion with dihydro-beta-erythroidine. These findings demonstrate a potent crosstalk between G protein-coupled receptors and ligand-gated ion channels in dopaminergic nerve terminals, with the D(2) autoreceptor modulating the efficacy of non-alpha(7) nACh receptor-mediated modulation of dopamine release. We further demonstrate physical interactions between beta(2) subunits of non-alpha(7) nicotinic acetylcholine receptors and D(2) autoreceptors in co-immunoprecipitation experiments with membrane preparations from co-transfected mammalian cells and rat striatum. These results reveal that striatal non-alpha(7) nicotinic acetylcholine receptors form part of heteromeric dopamine autoreceptor complexes that modulate dopamine release. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Quarta, Davide AU - Ciruela, Francisco AU - Patkar, Kshitij AU - Borycz, Janusz AU - Solinas, Marcello AU - Lluis, Carme AU - Franco, Rafael AU - Wise, Roy A AU - Goldberg, Steven R AU - Hope, Bruce T AU - Woods, Amina S AU - Ferré, Sergi AD - Behavioral Neuroscience Branch, National Institute on Drug Abuse, IRP, NIH, DHHS, Baltimore, MD 21224, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 35 EP - 42 VL - 32 IS - 1 SN - 0893-133X, 0893-133X KW - Dopamine Agonists KW - 0 KW - Dopamine Antagonists KW - Nicotinic Agonists KW - Receptors, Dopamine D2 KW - Receptors, Nicotinic KW - Quinpirole KW - 20OP60125T KW - Dihydro-beta-Erythroidine KW - 23255-54-1 KW - Raclopride KW - 430K3SOZ7G KW - Nicotine KW - 6M3C89ZY6R KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Drug Interactions KW - Dihydro-beta-Erythroidine -- pharmacology KW - Dose-Response Relationship, Drug KW - Dopamine Antagonists -- pharmacology KW - Humans KW - Raclopride -- pharmacology KW - Blotting, Western -- methods KW - Microdialysis -- methods KW - Rats KW - Transfection -- methods KW - Rats, Sprague-Dawley KW - Quinpirole -- pharmacology KW - Dopamine Agonists -- pharmacology KW - Nicotine -- pharmacology KW - Immunoprecipitation -- methods KW - Nicotinic Agonists -- pharmacology KW - Cell Line KW - Male KW - Corpus Striatum -- cytology KW - Presynaptic Terminals -- drug effects KW - Corpus Striatum -- metabolism KW - Dopamine -- metabolism KW - Corpus Striatum -- drug effects KW - Receptors, Nicotinic -- physiology KW - Receptors, Dopamine D2 -- physiology KW - Presynaptic Terminals -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68377368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Heteromeric+nicotinic+acetylcholine-dopamine+autoreceptor+complexes+modulate+striatal+dopamine+release.&rft.au=Quarta%2C+Davide%3BCiruela%2C+Francisco%3BPatkar%2C+Kshitij%3BBorycz%2C+Janusz%3BSolinas%2C+Marcello%3BLluis%2C+Carme%3BFranco%2C+Rafael%3BWise%2C+Roy+A%3BGoldberg%2C+Steven+R%3BHope%2C+Bruce+T%3BWoods%2C+Amina+S%3BFerr%C3%A9%2C+Sergi&rft.aulast=Quarta&rft.aufirst=Davide&rft.date=2007-01-01&rft.volume=32&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Silica-directed mast cell activation is enhanced by scavenger receptors. AN - 68376873; 16902192 AB - Inhalation of crystalline silica results in pulmonary fibrosis and silicosis. It has been suggested that mast cells play a role in these conditions. How mast cells would influence pathology is unknown. We thus explored mast cell interactions with silica in vitro and in B6.Cg-kit(W-sh) mast cell-deficient mice. B6.Cg-kit(W-sh) mice did not develop inflammation or significant collagen deposition after instillation of silica, while C57Bl/6 wild-type mice did have these findings. Given this supporting evidence of a role for mast cells in the development of silicosis, we examined the ability of silica to activate mouse bone marrow-derived mast cells (BMMC), including degranulation (beta-hexosaminidase release); production of reactive oxygen species (ROS) and inflammatory mediators; and the effects of silica on Fc epsilon RI-dependent activation. Silica did not induce mast cell degranulation. However, TNF-alpha, IL-13, monocyte chemotactic protein-1, protease activity, and production of ROS were dose-dependently increased after silica exposure, and production was enhanced after Fc epsilon RI stimulation. This mast cell activation was inhibited by anti-inflammatory compounds. As silica mediates some effects in macrophages through scavenger receptors (SRs), we first determined that mast cells express scavenger receptors; then explored the involvement of SR-A and macrophage receptor with colleagenous structure (MARCO). Silica-induced ROS formation, apoptosis, and TNF-alpha production were reduced in BMMC obtained from SR-A, MARCO, and SR-A/MARCO knockout mice. These findings demonstrate that silica directs mast cell production of inflammatory mediators, in part through SRs, providing insight into critical events in the pathogenesis and potential therapeutic targets in silicosis. JF - American journal of respiratory cell and molecular biology AU - Brown, Jared M AU - Swindle, Emily J AU - Kushnir-Sukhov, Nataliya M AU - Holian, Andrij AU - Metcalfe, Dean D AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA. jmbrown@niaid.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 43 EP - 52 VL - 36 IS - 1 SN - 1044-1549, 1044-1549 KW - Ccl2 protein, mouse KW - 0 KW - Chemokine CCL2 KW - Interleukin-13 KW - Marco protein, mouse KW - Reactive Oxygen Species KW - Receptors, IgE KW - Receptors, Immunologic KW - Scavenger Receptors, Class A KW - Tumor Necrosis Factor-alpha KW - Silicon Dioxide KW - 7631-86-9 KW - Collagen KW - 9007-34-5 KW - Index Medicus KW - Animals KW - Reactive Oxygen Species -- metabolism KW - Cell Degranulation KW - Apoptosis KW - Collagen -- metabolism KW - Interleukin-13 -- metabolism KW - Mice KW - Chemokine CCL2 -- metabolism KW - Mice, Knockout KW - Receptors, Immunologic -- genetics KW - Receptors, IgE -- metabolism KW - Cells, Cultured KW - Receptors, Immunologic -- metabolism KW - Mice, Inbred C57BL KW - Tumor Necrosis Factor-alpha -- metabolism KW - Bone Marrow Cells -- metabolism KW - Scavenger Receptors, Class A -- genetics KW - Silicosis -- pathology KW - Mast Cells -- metabolism KW - Silicon Dioxide -- toxicity KW - Mast Cells -- physiology KW - Bone Marrow Cells -- physiology KW - Scavenger Receptors, Class A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68376873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+respiratory+cell+and+molecular+biology&rft.atitle=Silica-directed+mast+cell+activation+is+enhanced+by+scavenger+receptors.&rft.au=Brown%2C+Jared+M%3BSwindle%2C+Emily+J%3BKushnir-Sukhov%2C+Nataliya+M%3BHolian%2C+Andrij%3BMetcalfe%2C+Dean+D&rft.aulast=Brown&rft.aufirst=Jared&rft.date=2007-01-01&rft.volume=36&rft.issue=1&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=American+journal+of+respiratory+cell+and+molecular+biology&rft.issn=10441549&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-12 N1 - Date created - 2006-12-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Exp Med. 2001 Sep 17;194(6):809-21 [11560996] J Immunol. 2002 Mar 15;168(6):2953-62 [11884467] Am J Respir Cell Mol Biol. 2002 Jul;27(1):78-84 [12091249] Toxicol Sci. 2003 Mar;72(1):150-7 [12604844] Clin Exp Immunol. 2003 Mar;131(3):415-21 [12605693] Annu Rev Immunol. 2003;21:425-56 [12615888] Trends Immunol. 2003 Apr;24(4):158-61 [12697439] Free Radic Biol Med. 2003 Jun 15;34(12):1507-16 [12788471] Microcirculation. 2003 Jun;10(3-4):273-88 [12851645] Toxicol Sci. 2003 Nov;76(1):91-101 [12857937] Eur J Pharmacol. 2003 Oct 8;478(2-3):179-85 [14575803] Toxicol Sci. 2003 Nov;76(1):1-2 [14619916] Toxicology. 2004 Feb 15;195(2-3):167-76 [14751672] J Immunol. 2004 Apr 1;172(7):4068-76 [15034018] Toxicol Sci. 2004 Jul;80(1):34-48 [15056807] J Exp Med. 2004 Jul 19;200(2):267-72 [15263032] J Immunol Methods. 1988 Nov 25;115(1):61-9 [3192948] Nature. 1990 Mar 15;344(6263):245-7 [2156165] Am J Respir Cell Mol Biol. 1993 Nov;9(5):475-83 [8217187] Cytometry. 1995 May 1;20(1):23-32 [7600897] J Immunol. 1995 Jul 1;155(1):367-76 [7541421] Toxicol Appl Pharmacol. 1996 Nov;141(1):84-92 [8917679] Am J Respir Crit Care Med. 1997 Feb;155(2):761-8 [9032226] Toxicol Appl Pharmacol. 2000 Jan 15;162(2):100-6 [10637133] Am J Respir Crit Care Med. 2000 Jun;161(6):2026-34 [10852784] Pneumonol Alergol Pol. 2000;68(3-4):109-19 [11004845] Arterioscler Thromb Vasc Biol. 2000 Dec;20(12):2593-9 [11116058] Immunol Rev. 2001 Feb;179:16-24 [11292019] Toxicol Appl Pharmacol. 2001 Jul 1;174(1):10-6 [11437644] J Exp Med. 2001 Jul 16;194(2):155-64 [11457890] Nature. 1997 Mar 20;386(6622):292-6 [9069289] J Clin Invest. 1997 Mar 15;99(6):1313-21 [9077541] Clin Exp Allergy. 1998 Dec;28(12):1509-17 [10024222] J Exp Med. 1999 May 3;189(9):1497-506 [10224290] Toxicol Appl Pharmacol. 1999 Aug 1;158(3):211-20 [10438654] J Leukoc Biol. 2004 Nov;76(5):926-32 [15292275] Anal Biochem. 1965 Apr;11:1-5 [14328641] Immunol Res. 2004;30(3):339-49 [15531774] J Pathol. 2004 Dec;204(5):594-604 [15538737] Int Arch Allergy Immunol. 2004 Dec;135(4):348-56 [15564778] Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L488-96 [15557088] Curr Opin Pulm Med. 2005 Mar;11(2):169-73 [15699791] Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L841-8 [15608148] MMWR Morb Mortal Wkly Rep. 2005 Apr 29;54(16):401-5 [15858459] Exp Lung Res. 2005 Jul-Aug;31(6):581-97 [16019989] Immunology. 2005 Sep;116(1):21-9 [16108814] Am J Pathol. 2005 Sep;167(3):835-48 [16127161] Am J Physiol Lung Cell Mol Physiol. 2005 Dec;289(6):L990-8 [16040631] J Biol Chem. 2005 Dec 2;280(48):40261-70 [16176929] Environ Health Perspect. 2003 May;111(5):708-13 [12727598] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CYP3A4 and pregnane X receptor humanized mice. AN - 68376494; 17936928 AB - Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450- and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (BAC) and P1 phage artificial chromosomes (PAC) genomic clones. In some cases, transgenic mice carrying the human genes are bred with null-mice to produce fully humanized mice. Mice expressing human CYP1A1, CYP1A2, CYP2E1, CYP2D6, CYP3A4, and CYP3A7 were generated and characterized. Studies with the CYP3A4-humanized (hCYP3A4) mouse line revealed new information on the physiological function of this P450 and its role in drug metabolism in vivo. With this mouse line, CYP3A4, under certain circumstances, was found to alter the serum levels of estrogen resulting in deficient lactation and low pup survival as a result of underdeveloped mammary glands. This hCYP3A4 mouse established the importance of intestinal CYP3A4 in the pharmacokinetics of orally administered drugs. The hCYP3A4 mice were also used to establish the mechanisms of potential gender differences in CYP3A4 expression (adult female > adult male) that could account for human gender differences in drug metabolism and response. The pregnane X receptor (PXR) is also involved in induction of drug metabolism through its target genes including CYP3A4. Since species differences exist in ligand specificity between human and mice, a PXR-humanized mouse (hPXR) was produced that responds to human PXR activators such as rifampicin but does not respond to the rodent activator pregnenalone 16alpha-carbonitrile. JF - Journal of biochemical and molecular toxicology AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. fjgonz@helix.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 158 EP - 162 VL - 21 IS - 4 SN - 1095-6670, 1095-6670 KW - Cytochrome P-450 Enzyme Inhibitors KW - 0 KW - Estrogens KW - Receptors, Steroid KW - pregnane X receptor KW - Cytochrome P-450 Enzyme System KW - 9035-51-2 KW - CYP3A protein, mouse KW - EC 1.14.14.1 KW - Midazolam KW - R60L0SM5BC KW - Ketoconazole KW - R9400W927I KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Models, Animal KW - Animals KW - Sex Factors KW - Humans KW - Midazolam -- pharmacokinetics KW - Chromosomes, Artificial, Bacterial KW - Mice KW - Mice, Transgenic KW - Estrogens -- blood KW - Mice, Knockout KW - Forecasting KW - Rifampin -- pharmacology KW - Ketoconazole -- pharmacology KW - Male KW - Receptors, Steroid -- physiology KW - Receptors, Steroid -- drug effects KW - Cytochrome P-450 Enzyme System -- genetics KW - Cytochrome P-450 Enzyme System -- physiology KW - Receptors, Steroid -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68376494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemical+and+molecular+toxicology&rft.atitle=CYP3A4+and+pregnane+X+receptor+humanized+mice.&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-01-01&rft.volume=21&rft.issue=4&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemical+and+molecular+toxicology&rft.issn=10956670&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2007-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Persistent sexual arousal syndrome: a case report and review of the literature. AN - 68376209; 17162489 AB - This article describes a case of persistent sexual arousal syndrome (PSAS) seen by the Gynecology Consult Service of the National Institutes of Health. This syndrome was first described in 2001 and is characterized by excessive and unrelenting sexual arousal in the absence of desire. PSAS has only recently come to the attention of the health care community, and its prevalence in the population is not completely known. It is important to report cases of this syndrome in order to help clarify its prevalence, etiology, and prognosis and to determine possible methods of treatment. JF - Journal of sex & marital therapy AU - Mahoney, Sheila AU - Zarate, Carlos AD - National Institutes of Health, National Institute of Child Health and Human Development, Reproductive Biology and Medicine Branch, Bethesda, Maryland 0892-1109, USA. manoneys@mail.nih.gov PY - 2007 SP - 65 EP - 71 VL - 33 IS - 1 SN - 0092-623X, 0092-623X KW - Antidepressive Agents, Second-Generation KW - 0 KW - Cyclohexanols KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Index Medicus KW - Orgasm -- drug effects KW - Syndrome KW - Humans KW - Health Status KW - Bipolar Disorder -- drug therapy KW - Adult KW - Depression -- drug therapy KW - Male KW - Female KW - Antidepressive Agents, Second-Generation -- adverse effects KW - Sexual Dysfunction, Physiological -- chemically induced KW - Sexual Dysfunction, Physiological -- diagnosis KW - Cyclohexanols -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68376209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+sex+%26+marital+therapy&rft.atitle=Persistent+sexual+arousal+syndrome%3A+a+case+report+and+review+of+the+literature.&rft.au=Mahoney%2C+Sheila%3BZarate%2C+Carlos&rft.aulast=Mahoney&rft.aufirst=Sheila&rft.date=2007-01-01&rft.volume=33&rft.issue=1&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=Journal+of+sex+%26+marital+therapy&rft.issn=0092623X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-11 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Structural basis for inhibition of translation by the tumor suppressor Pdcd4. AN - 68375990; 17060447 AB - The tumor suppressor function of Programmed Cell Death 4 (Pdcd4) is achieved through interactions between Pdcd4 and components of the translation initiation complex, namely, the RNA helicase eIF4A and the scaffolding protein eIF4G. These interactions are mediated through two MA3 domains on the Pdcd4 molecule and result in inhibition of protein synthesis. We have solved the high-resolution crystal structure of the C-terminal MA3 (cMA3) domain of Pdcd4 in several crystal forms and demonstrated its similarity to the MA3 domain of eIF4G. As predicted by the structure, the cMA3 domain competes with eIF4Gc for binding to eIF4A and surprisingly is sufficient to inhibit translation initiation. Mutations that abolish eIF4A binding negate both functions of the cMA3. Interestingly mutations in the Akt phosphorylation site influenced neither cMA3 binding to eIF4A nor its ability to inhibit translation initiation. Finally, our structural analysis reveals MA3 domains to be a novel subfamily of VHS domains. JF - Molecular and cellular biology AU - LaRonde-LeBlanc, Nicole AU - Santhanam, Arti N AU - Baker, Alyson R AU - Wlodawer, Alexander AU - Colburn, Nancy H AD - Macromolecular Crystallography Laboratory, CCR, National Cancer Institute, Frederick, MD 21702, USA. nlaronde@umd.edu Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 147 EP - 156 VL - 27 IS - 1 SN - 0270-7306, 0270-7306 KW - Apoptosis Regulatory Proteins KW - 0 KW - Eukaryotic Initiation Factor-4G KW - Pdcd4 protein, mouse KW - RNA-Binding Proteins KW - Eukaryotic Initiation Factor-4A KW - EC 2.7.7.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Eukaryotic Initiation Factor-4G -- physiology KW - Phosphorylation KW - Models, Molecular KW - Two-Hybrid System Techniques KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Eukaryotic Initiation Factor-4A -- physiology KW - Protein Binding KW - Protein Conformation KW - Protein Biosynthesis KW - Apoptosis Regulatory Proteins -- chemistry KW - RNA-Binding Proteins -- physiology KW - Apoptosis Regulatory Proteins -- physiology KW - Gene Expression Regulation KW - RNA-Binding Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68375990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biology&rft.atitle=Structural+basis+for+inhibition+of+translation+by+the+tumor+suppressor+Pdcd4.&rft.au=LaRonde-LeBlanc%2C+Nicole%3BSanthanam%2C+Arti+N%3BBaker%2C+Alyson+R%3BWlodawer%2C+Alexander%3BColburn%2C+Nancy+H&rft.aulast=LaRonde-LeBlanc&rft.aufirst=Nicole&rft.date=2007-01-01&rft.volume=27&rft.issue=1&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-18 N1 - Date created - 2006-12-14 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 2ION; PDB; 2NSZ; 2IOL; 2IOS N1 - SuppNotes - Cited By: Mol Cell. 2001 Jan;7(1):193-203 [11172724] Oncogene. 2001 Feb 8;20(6):669-76 [11314000] J Biol Chem. 2001 Jan 26;276(4):2872-9 [11060291] Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10037-41 [11517324] Mol Cell. 2001 Aug;8(2):383-96 [11545740] Int J Cancer. 2002 Mar 10;98(2):181-5 [11857405] FEBS Lett. 2002 Feb 20;513(1):19-23 [11911875] Biochem Biophys Res Commun. 2002 Sep 13;297(1):78-82 [12220511] Mol Cell Biol. 2003 Jan;23(1):26-37 [12482958] Methods Enzymol. 2003;374:22-37 [14696367] Mol Cancer Ther. 2004 Feb;3(2):103-10 [14985450] Nat Struct Mol Biol. 2004 Apr;11(4):330-7 [15004547] Mol Cell Biol. 2004 May;24(9):3894-906 [15082783] J Mol Biol. 1993 Sep 5;233(1):123-38 [8377180] Gene. 1995 Dec 12;166(2):297-301 [8543179] J Struct Biol. 1999 Apr-May;125(2-3):156-65 [10222271] Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32 [15572765] J Biol Chem. 2005 Jan 21;280(3):1872-81 [15528191] RNA. 2005 Mar;11(3):261-74 [15661843] Cancer Res. 2005 Jul 15;65(14):6034-41 [16024603] Genes Dev. 2005 Sep 15;19(18):2212-23 [16166382] Cancer Res. 2005 Dec 15;65(24):11282-6 [16357133] Mol Cell Biol. 2006 Feb;26(4):1297-306 [16449643] Structure. 2006 May;14(5):913-23 [16698552] Science. 2006 Oct 20;314(5798):467-71 [17053147] J Biomol NMR. 2006;36 Suppl 1:18 [16518566] Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14037-42 [10570194] Annu Rev Cell Dev Biol. 1999;15:269-90 [10611963] Mol Cell Biol. 2000 Jan;20(2):468-77 [10611225] Anticancer Res. 2000 May-Jun;20(3A):1343-51 [10928042] Biochemistry. 2000 Sep 19;39(37):11282-90 [10985773] Trends Biochem Sci. 2000 Sep;25(9):423-6 [10973054] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The influence of genetic polymorphisms in Ahr, CYP1A1, CYP1A2, CYP1B1, GST M1, GST T1 and UGT1A1 on urine 1-hydroxypyrene glucuronide concentrations in healthy subjects from Rio Grande do Sul, Brazil. AN - 68375286; 16864595 AB - Polymorphisms in genes encoding polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes may alter metabolism of these carcinogens and contribute to inter-individual difference in urine concentrations. We investigated the influence of genetic polymorphism on PAH metabolism in urine from 199 healthy subjects from Southern Brazil. We measured urine 1-hydroxypyrene glucuronide (1-OHPG) concentrations using immunoaffinity chromatography and synchronous fluorescence spectroscopy and genotyped subjects using standard methods. Genetic variants in CYP1B1 (rs1056827, rs1800440, rs10012) were strongly associated with urine 1-OHPG with P-values < 0.010. Variants in aryl hydrocarbon receptor (Ahr) (rs4986826), CYP1A1 (rs1799814) and CYP1A2 (rs2069514) were also, although less strongly, associated with changes in urine 1-OHPG concentrations. These variants had P-values of 0.074, 0.040 and 0.025, respectively. The median urine 1-OHPG concentrations (pmol/ml) in the homozygous wild-type and homozygous variants for CYP1B1 (rs10012) and the Ahr, CYP1A1 and CYP1A2 variants listed above were 2.16 and 0.10, 2.16 and 0.41, 2.03 and 0.46, 2.19 and 2.79, respectively. We found no effect of deletions in GST M1 or GST T1, or different alleles of UGT1A1*28. Adjusting for age, sex, place of residence, tobacco smoke exposure, maté drinking, cachaça and barbeque preparation had only a minor impact on the associations. A model containing just exposure variables had an r2 of 0.21; a model with single genotypes for Ahr, CYP1A1, CYP1A2 and CYP1B1 had an r2 of 0.10; and a model combining both exposure and genotype information had a total r2 of 0.33. Our results suggest that CYP1B1 genotypes are strongly associated with urine 1-OHPG concentrations in this population. JF - Carcinogenesis AU - Abnet, Christian C AU - Fagundes, Renato B AU - Strickland, Paul T AU - Kamangar, Farin AU - Roth, Mark J AU - Taylor, Philip R AU - Dawsey, Sanford M AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, EPS/320, MSC 7232, Rockville, MD 20852, USA. abnetc@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 112 EP - 117 VL - 28 IS - 1 SN - 0143-3334, 0143-3334 KW - 1-hydroxypyrene-glucuronide KW - 0 KW - Glucuronates KW - Pyrenes KW - Receptors, Aryl Hydrocarbon KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP1B1 protein, human KW - Cytochrome P-450 CYP1A1 KW - Cytochrome P-450 CYP1A2 KW - Cytochrome P-450 CYP1B1 KW - UGT1A1 enzyme KW - EC 2.4.1.- KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase M1 KW - Index Medicus KW - Chromatography, Affinity KW - Humans KW - Brazil -- epidemiology KW - Middle Aged KW - Male KW - Female KW - Glucuronosyltransferase -- genetics KW - Cytochrome P-450 CYP1A1 -- genetics KW - Cytochrome P-450 CYP1A2 -- genetics KW - Polymorphism, Genetic KW - Glucuronates -- urine KW - Receptors, Aryl Hydrocarbon -- genetics KW - Glutathione Transferase -- genetics KW - Aryl Hydrocarbon Hydroxylases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68375286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=The+influence+of+genetic+polymorphisms+in+Ahr%2C+CYP1A1%2C+CYP1A2%2C+CYP1B1%2C+GST+M1%2C+GST+T1+and+UGT1A1+on+urine+1-hydroxypyrene+glucuronide+concentrations+in+healthy+subjects+from+Rio+Grande+do+Sul%2C+Brazil.&rft.au=Abnet%2C+Christian+C%3BFagundes%2C+Renato+B%3BStrickland%2C+Paul+T%3BKamangar%2C+Farin%3BRoth%2C+Mark+J%3BTaylor%2C+Philip+R%3BDawsey%2C+Sanford+M&rft.aulast=Abnet&rft.aufirst=Christian&rft.date=2007-01-01&rft.volume=28&rft.issue=1&rft.spage=112&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2006-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic impairment of frontocortical endocannabinoid degradation and high alcohol preference. AN - 68372236; 16482090 AB - Endocannabinoid signaling has recently been implicated in ethanol-seeking behavior. We analyzed the expression of endocannabinoid-related genes in key brain regions of reward and dependence, and compared them between the alcohol-preferring AA (Alko Alcohol) and nonpreferring ANA (Alko Non-Alcohol) rat lines. A decreased expression of fatty acid amidohydrolase (FAAH), the main endocannabinoid-degrading enzyme, was found in prefrontal cortex (PFC) of AA rats, and was accompanied by decreased enzyme activity in this region. Binding of the endocannabinoid-cannabinoid 1 (CB1) receptor ligand (3)[H]SR141716A, and [35S]GTPgammaS incorporation stimulated by the CB1 agonist WIN 55,212-2 were downregulated in the same area. Together, this suggests an overactive endocannabinoid transmission in the PFC of AA animals, and a compensatory downregulation of CB1 signaling. The functional role of impaired FAAH function for alcohol self-administration was validated in two independent ways. The CB1 antagonist SR141716A potently and dose-dependently suppressed self-administration in AA rats when given systemically, or locally into the PFC, but not in the striatum. Conversely, intra-PFC injections of the competitive FAAH inhibitor URB597 increased ethanol self-administration in nonselected Wistar rats. These results show for the first time that impaired FAAH function may confer a phenotype of high voluntary alcohol intake, and point to a FAAH both as a potential susceptibility factor and a therapeutic target. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Hansson, Anita C AU - Bermúdez-Silva, Francisco J AU - Malinen, Hanna AU - Hyytiä, Petri AU - Sanchez-Vera, Irene AU - Rimondini, Roberto AU - Rodriguez de Fonseca, Fernando AU - Kunos, George AU - Sommer, Wolfgang H AU - Heilig, Markus AD - Laboratory of Clinical and Translational Studies, NIAAA, National Institutes of Health, Bethesda, MD 20892-1108, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 117 EP - 126 VL - 32 IS - 1 SN - 0893-133X, 0893-133X KW - Analgesics KW - 0 KW - Benzamides KW - Benzoxazines KW - Cannabinoid Receptor Modulators KW - Carbamates KW - Central Nervous System Depressants KW - Endocannabinoids KW - Morpholines KW - Naphthalenes KW - Piperidines KW - Pyrazoles KW - RNA, Messenger KW - Receptor, Cannabinoid, CB1 KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Guanosine 5'-O-(3-Thiotriphosphate) KW - 37589-80-3 KW - Ethanol KW - 3K9958V90M KW - Win 55212-2 KW - 5H31GI9502 KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - rimonabant KW - RML78EN3XE KW - Index Medicus KW - Naphthalenes -- pharmacology KW - Carbamates -- pharmacology KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Brain Chemistry -- drug effects KW - Piperidines -- pharmacokinetics KW - Morpholines -- pharmacology KW - Ethanol -- administration & dosage KW - Analgesics -- pharmacology KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - Pyrazoles -- pharmacokinetics KW - Central Nervous System Depressants -- administration & dosage KW - Rats KW - Amidohydrolases -- metabolism KW - Behavior, Animal -- drug effects KW - Self Administration -- methods KW - RNA, Messenger -- metabolism KW - Benzamides -- pharmacology KW - Amidohydrolases -- genetics KW - Brain Chemistry -- genetics KW - In Situ Hybridization -- methods KW - Guanosine 5'-O-(3-Thiotriphosphate) -- pharmacokinetics KW - Male KW - Gene Expression -- drug effects KW - Cannabinoid Receptor Modulators -- metabolism KW - Prefrontal Cortex -- metabolism KW - Receptor, Cannabinoid, CB1 -- genetics KW - Receptor, Cannabinoid, CB1 -- metabolism KW - Alcohol Drinking -- genetics KW - Gene Expression -- physiology KW - Prefrontal Cortex -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68372236?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Genetic+impairment+of+frontocortical+endocannabinoid+degradation+and+high+alcohol+preference.&rft.au=Hansson%2C+Anita+C%3BBerm%C3%BAdez-Silva%2C+Francisco+J%3BMalinen%2C+Hanna%3BHyyti%C3%A4%2C+Petri%3BSanchez-Vera%2C+Irene%3BRimondini%2C+Roberto%3BRodriguez+de+Fonseca%2C+Fernando%3BKunos%2C+George%3BSommer%2C+Wolfgang+H%3BHeilig%2C+Markus&rft.aulast=Hansson&rft.aufirst=Anita&rft.date=2007-01-01&rft.volume=32&rft.issue=1&rft.spage=117&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-12-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evidence for a cooperative role of gelatinase A and membrane type-1 matrix metalloproteinase during Xenopus laevis development. AN - 68368378; 17055228 AB - Matrix metalloproteinases (MMPs) are a large family of extracellular or membrane-bound proteases. Their ability to cleave extracellular matrix (ECM) proteins has implicated a role in ECM remodeling to affect cell fate and behavior during development and in pathogenesis. We have shown previously that membrane-type 1 (MT1)-MMP [corrected] is coexpressed temporally and spatially with the MMP gelatinase A (GelA) in all cell types of the intestine and tail where GelA is expressed during Xenopus laevis metamorphosis, suggesting a cooperative role of these MMPs in development. Here, we show that Xenopus GelA and MT1-MMP interact with each other in vivo and that overexpression of MT1-MMP and GelA together in Xenopus embryos leads to the activation of pro-GelA. We further show that both MMPs are expressed during Xenopus embryogenesis, although MT1-MMP gene is expressed earlier than the GelA gene. To investigate whether the embryonic MMPs play a role in development, we have studied whether precocious expression of these MMPs alters development. Our results show that overexpression of both MMPs causes developmental abnormalities and embryonic death by a mechanism that requires the catalytic activity of the MMPs. More importantly, we show that coexpression of wild type MT1-MMP and GelA leads to a cooperative effect on embryonic development and that this cooperative effect is abolished when the catalytic activity of either MMP is eliminated through a point mutation in the catalytic domain. Thus, our studies support a cooperative role of these MMPs in embryonic development, likely through the activation of pro-GelA by MT1-MMP. JF - Mechanisms of development AU - Hasebe, Takashi AU - Hartman, Rebecca AU - Fu, Liezhen AU - Amano, Tosikazu AU - Shi, Yun-Bo AD - Section on Molecular Morphogenesis, Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bldg. 18T, Rm. 106, Bethesda, MD 20892, USA. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 11 EP - 22 VL - 124 IS - 1 SN - 0925-4773, 0925-4773 KW - Recombinant Proteins KW - 0 KW - DNA KW - 9007-49-2 KW - Matrix Metalloproteinase 2 KW - EC 3.4.24.24 KW - Matrix Metalloproteinase 14 KW - EC 3.4.24.80 KW - Index Medicus KW - Animals KW - Extracellular Matrix -- metabolism KW - Enzyme Activation KW - Animals, Genetically Modified KW - Recombinant Proteins -- genetics KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Gene Expression Regulation, Enzymologic KW - Recombinant Proteins -- metabolism KW - DNA -- genetics KW - Catalytic Domain -- genetics KW - Point Mutation KW - Recombinant Proteins -- chemistry KW - Protein Structure, Tertiary KW - Gene Expression Regulation, Developmental KW - Xenopus laevis -- genetics KW - Xenopus laevis -- metabolism KW - Matrix Metalloproteinase 14 -- metabolism KW - Matrix Metalloproteinase 2 -- genetics KW - Xenopus laevis -- embryology KW - Matrix Metalloproteinase 14 -- chemistry KW - Matrix Metalloproteinase 2 -- metabolism KW - Matrix Metalloproteinase 14 -- genetics KW - Matrix Metalloproteinase 2 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mechanisms+of+development&rft.atitle=Evidence+for+a+cooperative+role+of+gelatinase+A+and+membrane+type-1+matrix+metalloproteinase+during+Xenopus+laevis+development.&rft.au=Hasebe%2C+Takashi%3BHartman%2C+Rebecca%3BFu%2C+Liezhen%3BAmano%2C+Tosikazu%3BShi%2C+Yun-Bo&rft.aulast=Hasebe&rft.aufirst=Takashi&rft.date=2007-01-01&rft.volume=124&rft.issue=1&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Mechanisms+of+development&rft.issn=09254773&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Dev Biol. 1998 Nov 1;203(1):24-35 [9806770] J Cell Sci. 1999 Mar;112 ( Pt 6):773-84 [10036228] APMIS. 1999 Jan;107(1):38-44 [10190278] APMIS. 1999 Jan;107(1):137-43 [10190290] Cell Res. 1999 Jun;9(2):91-105 [10418731] Cell. 1999 Oct 1;99(1):81-92 [10520996] Cell Res. 2005 Mar;15(3):150-9 [15780176] J Biol Chem. 2005 Jul 1;280(26):25079-86 [15878869] J Biol Chem. 2005 Jul 29;280(30):27856-65 [15929979] J Biol Chem. 2005 Dec 23;280(51):42237-41 [16251193] Cell Tissue Res. 2006 Apr;324(1):105-16 [16418836] Int J Mol Med. 1998 Sep;2(3):273-82 [9855698] Dev Biol. 1998 Nov 1;203(1):12-23 [9806769] J Biol Chem. 1999 Nov 26;274(48):34260-6 [10567400] Cell Res. 1999 Dec;9(4):291-303 [10628838] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7 [10737763] Genes Dev. 2000 Sep 1;14(17):2123-33 [10970876] J Cell Biol. 2000 Sep 4;150(5):1177-88 [10974004] EMBO J. 2001 Sep 3;20(17):4782-93 [11532942] Curr Opin Cell Biol. 2001 Oct;13(5):534-40 [11544020] Annu Rev Cell Dev Biol. 2001;17:463-516 [11687497] Cell Res. 2001 Dec;11(4):245-52 [11787769] Dev Dyn. 2002 Mar;223(3):402-13 [11891989] Science. 2002 Mar 29;295(5564):2387-92 [11923519] Mol Reprod Dev. 2002 Aug;62(4):470-6 [12112579] Oncogene. 2002 Aug 29;21(38):5861-7 [12185585] Mol Biotechnol. 2002 Sep;22(1):51-86 [12353914] Matrix Biol. 2003 May;22(3):279-93 [12853038] Curr Opin Cell Biol. 2004 Oct;16(5):558-64 [15363807] Biochim Biophys Acta. 1987 Nov 25;907(3):191-217 [2823896] J Biol Chem. 1988 Aug 25;263(24):11892-9 [2841336] Int Rev Cytol. 1989;119:97-149 [2695486] Proc Natl Acad Sci U S A. 1990 Jul;87(14):5578-82 [2164689] Int J Cancer. 1992 Mar 12;50(5):791-5 [1544713] Matrix Suppl. 1992;1:237-44 [1480033] Crit Rev Oral Biol Med. 1993;4(2):197-250 [8435466] Semin Cell Biol. 1993 Jun;4(3):161-73 [8347833] Curr Opin Cell Biol. 1993 Oct;5(5):891-7 [8240832] Annu Rev Cell Biol. 1993;9:541-73 [8280471] Curr Opin Cell Biol. 1993 Dec;5(6):1029-35 [8129940] Biochemistry. 1994 May 31;33(21):6684-90 [7911325] J Biol Chem. 1994 Oct 14;269(41):25328-34 [7929226] Int J Dev Biol. 1994 Jun;38(2):345-50 [7981043] Dev Biol. 1995 Jan;167(1):252-62 [7851646] Nature. 1995 May 18;375(6528):244-7 [7746327] Cell Tissue Res. 1996 Feb;283(2):325-9 [8593661] Kidney Int Suppl. 1996 May;54:S68-74 [8731199] Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1924-9 [8700860] Cancer Metastasis Rev. 1995 Dec;14(4):351-62 [8821095] Mol Biol Cell. 1996 Oct;7(10):1471-83 [8898355] Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1402-7 [9037065] Curr Opin Cell Biol. 1997 Oct;9(5):701-6 [9330874] J Cell Biol. 1998 Mar 23;140(6):1535-41 [9508784] EMBO J. 1998 Apr 15;17(8):2298-307 [9545242] Cell. 1998 May 1;93(3):411-22 [9590175] Cell Res. 1998 Sep;8(3):171-7 [9791730] Cell Res. 1998 Sep;8(3):179-86 [9791731] Cell Res. 1998 Sep;8(3):187-94 [9791732] Curr Opin Cell Biol. 1998 Oct;10(5):602-8 [9818170] Erratum In: Mech Dev. 2007 May;124(5):407-8 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mapping convulsants' binding to the GABA-A receptor chloride ionophore: a proposed model for channel binding sites. AN - 68368288; 16959376 AB - Gamma-aminobutyric acid (GABA) type A receptors play a key role in brain inhibitory neurotransmission, and are ligand-activated chloride channels blocked by numerous convulsant ligands. Here we summarize data on binding of picrotoxin, tetrazoles, beta-lactams, bicyclophosphates, butyrolactones and neurotoxic pesticides to GABA-A ionophore, and discuss functional and structural overlapping of their binding sites. The paper reviews data on convulsants' binding sensitivity to different point mutations in ionophore-lining second trans-membrane domains of GABA-A subunits, and maps possible location of convulsants' sites within the chloride ionophore. We also discuss data on inhibition of glycine, glutamate, serotonin (5-HT3) and N-acetylcholine receptors by GABA-A channel blockers, and examine the applicability of this model to other homologous ionotropic receptors. Positioning various convulsant-binding sites within ionophore of GABA-A receptors, this model enables a better understanding of complex architectonics of ionotropic receptors, and may be used for developing new channel-modulating drugs. JF - Neurochemistry international AU - Kalueff, A V AD - Laboratory of Clinical Science, Building 10, Room 3D41, National Institute of Mental Health (NIMH), NIH, 10 Center Dr. MSC 1264, Bethesda, MD 20892-1264, USA. kalueva@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 61 EP - 68 VL - 50 IS - 1 SN - 0197-0186, 0197-0186 KW - Convulsants KW - 0 KW - Ligands KW - Receptors, GABA-A KW - Index Medicus KW - Animals KW - Humans KW - Binding Sites KW - Convulsants -- metabolism KW - Receptors, GABA-A -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68368288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=Mapping+convulsants%27+binding+to+the+GABA-A+receptor+chloride+ionophore%3A+a+proposed+model+for+channel+binding+sites.&rft.au=Kalueff%2C+A+V&rft.aulast=Kalueff&rft.aufirst=A&rft.date=2007-01-01&rft.volume=50&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Pharmacol Exp Ther. 1990 Aug;254(2):578-83 [2166797] Mol Pharmacol. 1991 Jan;39(1):79-84 [1846222] Life Sci. 1991;49(11):PL49-54 [1875786] J Physiol. 1992 Feb;447:191-213 [1317428] J Physiol. 1992 Jan;445:97-127 [1323672] Brain Res. 1992 Nov 13;595(2):249-55 [1281737] Nature. 1993 Jun 3;363(6428):449-51 [8389005] Brain Res. 1993 Jun 25;615(1):170-4 [8395954] J Physiol. 1993 May;464:423-39 [8229811] Mol Pharmacol. 1993 Oct;44(4):860-5 [8232235] Brain Dev. 1993 Sep-Oct;15(5):356-61 [8279650] Brain Res Bull. 1994;33(4):373-8 [8124576] Nature. 1995 Jan 5;373(6509):37-43 [7800037] J Pharmacol Exp Ther. 1995 Feb;272(2):597-603 [7531762] Eur J Pharmacol. 1994 Dec 15;288(1):61-8 [7705469] Neuroscience. 1995 Jan;64(1):229-39 [7708208] J Biol Chem. 1995 Jun 9;270(23):13799-806 [7775436] J Neurochem. 2000 Mar;74(3):1310-6 [10693965] Br J Pharmacol. 2000 Jan;129(2):402-8 [10694249] Brain Res Mol Brain Res. 2000 Mar 10;76(1):47-55 [10719214] Biophys J. 2000 Apr;78(4):1786-803 [10733960] Curr Drug Targets CNS Neurol Disord. 2003 Dec;2(6):363-74 [14683464] Prog Neuropsychopharmacol Biol Psychiatry. 2004 Jan;28(1):105-13 [14687864] Biochem Biophys Res Commun. 2004 Apr 9;316(3):636-42 [15033447] J Pharmacol Exp Ther. 2004 May;309(2):677-83 [14742738] J Biol Chem. 2004 May 14;279(20):20906-14 [15007065] Eur J Pharmacol. 2004 Aug 2;496(1-3):23-32 [15288571] Neuroreport. 2004 Aug 26;15(12):1969-73 [15305147] Biochem Pharmacol. 2004 Oct 15;68(8):1675-84 [15451411] Toxicol Lett. 2004 Dec 1;154(1-2):55-60 [15475178] Mol Pharmacol. 1995 Jun;47(6):1217-23 [7603463] Mol Pharmacol. 1995 Nov;48(5):835-40 [7476913] Proc Natl Acad Sci U S A. 1995 Dec 5;92(25):11751-5 [8524842] Receptors Channels. 1995;3(1):13-20 [8589989] Br J Pharmacol. 1995 Dec;116(7):3014-20 [8680737] Naunyn Schmiedebergs Arch Pharmacol. 1996 Feb;353(3):306-13 [8692286] Neuropharmacology. 1996 Feb;35(2):123-36 [8734480] J Membr Biol. 1996 Nov;154(1):11-21 [8881023] Neurochem Int. 1996 Oct;29(4):361-70 [8939444] J Mol Evol. 1997 May;44(5):501-8 [9115174] Depress Anxiety. 1996-1997;4(3):100-10 [9166638] Mol Pharmacol. 1997 Jul;52(1):114-9 [9224820] J Pharmacol Exp Ther. 1997 Aug;282(2):827-33 [9262347] Br J Pharmacol. 1997 Oct;122(4):726-32 [9375970] Eur J Neurosci. 1997 Nov;9(11):2225-35 [9464918] Brain Res. 1998 Jan 5;780(1):20-6 [9473568] Bioorg Med Chem. 1998 Jan;6(1):43-55 [9502104] Brain Res. 1998 Apr 20;790(1-2):334-8 [9593978] Eur J Pharmacol. 1998 Mar 5;344(2-3):269-77 [9600663] Neurochem Int. 1998 Oct;33(4):353-8 [9840226] J Neurochem. 1999 Jan;72(1):318-26 [9886084] J Biol Chem. 1999 Sep 3;274(36):25350-4 [10464261] Br J Pharmacol. 1999 Jul;127(6):1349-58 [10455284] J Neurosci. 2004 Dec 15;24(50):11226-35 [15601928] Trends Pharmacol Sci. 2005 Jan;26(1):36-43 [15629203] J Biol Chem. 2005 Jan 14;280(2):1573-81 [15522864] J Mol Biol. 2005 Mar 4;346(4):967-89 [15701510] Neurochem Int. 2005 Mar;46(4):281-91 [15707693] Expert Opin Investig Drugs. 2005 May;14(5):601-18 [15926867] J Pharmacol Exp Ther. 2005 Jul;314(1):320-8 [15814570] J Neurosci. 2005 Oct 12;25(41):9358-66 [16221844] J Biol Chem. 2005 Oct 28;280(43):35836-43 [16109711] Neurochem Res. 2005 Dec;30(12):1471-82 [16362766] Pharmacol Ther. 2004 Aug;103(2):109-20 [15369679] Curr Opin Pharmacol. 2006 Feb;6(1):18-23 [16376150] Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5185-90 [16537435] Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6081-2 [16606858] Biochemistry. 2006 Jun 13;45(23):7013-22 [16752892] Invert Neurosci. 2006 Jun;6(2):75-9 [16758255] Life Sci. 1984 Oct 1;35(14):1439-44 [6090836] Cell Mol Neurobiol. 1987 Mar;7(1):97-103 [3594520] FASEB J. 1987 Oct;1(4):262-71 [2443413] Neuroscience. 1987 Sep;22(3):1123-33 [2825069] Neurotoxicol Teratol. 1990 Jan-Feb;12(1):57-63 [1690344] J Chem Neuroanat. 1990 Jan-Feb;3(1):59-76 [2156526] Mol Pharmacol. 1990 Apr;37(4):578-82 [2157964] Neurosci Lett. 2000 May 19;285(3):193-6 [10806319] J Med Genet. 2000 Oct;37(10):729-40 [11015449] J Pharmacol Exp Ther. 2000 Dec;295(3):1051-60 [11082440] J Neurochem. 2001 Feb;76(4):1109-20 [11181831] Brain Res Mol Brain Res. 2001 Jan 31;86(1-2):168-78 [11165383] Nat Neurosci. 2001 May;4(5):477-85 [11319555] Pharmacol Ther. 2000 Dec;88(3):197-212 [11337025] Pharmacol Ther. 2000 Dec;88(3):213-27 [11337026] Neurosci Lett. 2001 Jun 1;305(1):77-80 [11356312] J Biol Chem. 2001 Mar 16;276(11):7775-81 [11114302] Prog Neuropsychopharmacol Biol Psychiatry. 2001 Aug;25(6):1323-40 [11474848] J Pharmacol Exp Ther. 2001 Sep;298(3):986-95 [11504794] J Biol Chem. 2001 Sep 28;276(39):36275-80 [11466317] Br J Psychiatry. 2001 Nov;179:390-6 [11689393] Br J Pharmacol. 2002 Jan;135(2):427-32 [11815378] J Biol Chem. 2002 Mar 15;277(11):9112-7 [11744711] Physiol Rev. 2002 Apr;82(2):503-68 [11917096] J Biol Chem. 2002 May 17;277(20):17438-47 [11877425] Prog Neurobiol. 2002 Jun;67(2):113-59 [12126658] J Neurosci. 2002 Oct 1;22(19):8411-21 [12351715] J Biol Chem. 2002 Nov 1;277(44):41438-47 [12177063] J Biol Chem. 2002 Nov 22;277(47):44845-53 [12239220] J Biol Chem. 2002 Nov 29;277(48):46020-5 [12324466] Brain Res. 2003 Jan 3;959(1):173-81 [12480172] Neuroscience. 2003;117(2):397-403 [12614680] Neuropharmacology. 2003 Mar;44(4):431-8 [12646280] Neuropharmacology. 2003 Jun;44(8):994-1002 [12763092] Nature. 2003 Jun 26;423(6943):949-55 [12827192] Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):207-12 [12871031] Curr Drug Targets CNS Neurol Disord. 2003 Aug;2(4):213-32 [12871032] Neuropharmacology. 2003 Sep;45(3):304-14 [12871648] Eur J Pharmacol. 2003 Aug 22;476(1-2):17-24 [12969744] Brain Res Mol Brain Res. 2003 Nov 26;119(2):207-12 [14625088] FEBS Lett. 2003 Nov 27;555(1):91-5 [14630325] Arch Insect Biochem Physiol. 2003 Dec;54(4):145-56 [14635176] Neurotoxicology. 2003 Dec;24(6):817-24 [14637376] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Water-soluble ions in nano/ultrafine/fine/coarse particles collected near a busy road and at a rural site. AN - 68367521; 16772108 AB - This study investigated water-soluble ions in the sized particles (particularly nano (PM(0.01-0.056))/ultrafine (PM(0.01-0.1))) collected using MOUDI and Nano-MOUDI samplers near a busy road site and at a rural site. The analytical results demonstrate that nano and coarse particles exhibited the highest (16.3%) and lowest (8.37%) nitrate mass ratios, respectively. The mass ratio of NO(3)(-) was higher than that of SO(4)(2-) in all the sized particles at the traffic site. The secondary aerosols all displayed trimodal distributions. The aerosols in ultrafine particles collected at the roadside site exhibited Aitken mode distributions indicating they were of local origin. This finding was not observed for those ultrafine particles collected at the rural site. The mass median diameters (MMDs) of the nano, ultrafine, and fine particles were smaller at the traffic site than at the rural site, possibly related to the contribution of mobile engine emissions. JF - Environmental pollution (Barking, Essex : 1987) AU - Lin, Chih-Chung AU - Chen, Shui-Jen AU - Huang, Kuo-Lin AU - Lee, Wen-Jhy AU - Lin, Wen-Yinn AU - Liao, Chiu-Jung AU - Chaung, Hso-Chi AU - Chiu, Chuen-Huey AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, 1 Hseuh Fu RD., Nei Pu, PingTung 91201, Taiwan. Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 562 EP - 570 VL - 145 IS - 2 SN - 0269-7491, 0269-7491 KW - Aerosols KW - 0 KW - Air Pollutants KW - Ions KW - Nitrates KW - Quaternary Ammonium Compounds KW - Sulfates KW - Vehicle Emissions KW - Water KW - 059QF0KO0R KW - Chlorine KW - 4R7X1O2820 KW - Sodium KW - 9NEZ333N27 KW - Magnesium KW - I38ZP9992A KW - Potassium KW - RWP5GA015D KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Rural Health KW - Quaternary Ammonium Compounds -- analysis KW - Chlorine -- analysis KW - Solubility KW - Sodium -- analysis KW - Sulfates -- analysis KW - Particle Size KW - Magnesium -- analysis KW - Nanoparticles -- analysis KW - Nitrates -- analysis KW - Potassium -- analysis KW - Environmental Monitoring -- methods KW - Aerosols -- analysis KW - Ions -- analysis KW - Air Pollutants -- analysis KW - Vehicle Emissions -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68367521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.atitle=Water-soluble+ions+in+nano%2Fultrafine%2Ffine%2Fcoarse+particles+collected+near+a+busy+road+and+at+a+rural+site.&rft.au=Lin%2C+Chih-Chung%3BChen%2C+Shui-Jen%3BHuang%2C+Kuo-Lin%3BLee%2C+Wen-Jhy%3BLin%2C+Wen-Yinn%3BLiao%2C+Chiu-Jung%3BChaung%2C+Hso-Chi%3BChiu%2C+Chuen-Huey&rft.aulast=Lin&rft.aufirst=Chih-Chung&rft.date=2007-01-01&rft.volume=145&rft.issue=2&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Environmental+pollution+%28Barking%2C+Essex+%3A+1987%29&rft.issn=02697491&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The biological bases of nicotine and alcohol co-addiction. AN - 68364998; 17161671 JF - Biological psychiatry AU - Li, Ting-Kai AU - Volkow, Nora D AU - Baler, Ruben D AU - Egli, Mark AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9589, USA. Y1 - 2007/01/01/ PY - 2007 DA - 2007 Jan 01 SP - 1 EP - 3 VL - 61 IS - 1 SN - 0006-3223, 0006-3223 KW - Index Medicus KW - Animals KW - Humans KW - Alcohol-Related Disorders -- complications KW - Alcohol-Related Disorders -- genetics KW - Tobacco Use Disorder -- therapy KW - Tobacco Use Disorder -- epidemiology KW - Tobacco Use Disorder -- genetics KW - Alcohol-Related Disorders -- therapy KW - Tobacco Use Disorder -- complications KW - Biology KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68364998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=The+biological+bases+of+nicotine+and+alcohol+co-addiction.&rft.au=Li%2C+Ting-Kai%3BVolkow%2C+Nora+D%3BBaler%2C+Ruben+D%3BEgli%2C+Mark&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-01-01&rft.volume=61&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asthma phenotypes. AN - 68359974; 17133120 AB - Asthma is a heterogeneous disorder presenting with many phenotypes. Precise phenotypic definition has eluded the medical research community for years, despite recognition of different disease subtypes. Improved phenotypic characterization and knowledge of underlying pathobiology is necessary for linkage of specific genotypes with clinical disease manifestations. Phenotyping has been difficult because asthma is likely to be comprised of overlapping syndromes with varying origins and heterogeneous pathobiology. Currently, the field is too reliant on classification by trigger or symptoms. Since genotypic and phenotypic heterogeneity are inherent in asthma, patients presenting with different asthma phenotypes may need tailored therapies. Studies have begun to link genetics with disease mechanism and therapeutic response. As disease etiology, onset, progression and severity vary greatly among patients, however, the relative contribution of genetic factors may be difficult to ascertain. Definition of the full array of complex biological consequences of molecular target modulation is a prerequisite for therapies based on this concept. The advent of targeted therapies for asthma and clinical trials based on phenotype and genotype have raised interest in more accurate description of asthma phenotypes. Therapies based on phenotypic and genotypic characteristics may be useful in asthma management. A variety of factors, however, must be addressed before such approaches become standard. JF - Current opinion in pulmonary medicine AU - Kiley, James AU - Smith, Robert AU - Noel, Patricia AD - Division of Lung Diseases, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7952, USA. kileyj@nhlbi.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 19 EP - 23 VL - 13 IS - 1 SN - 1070-5287, 1070-5287 KW - Glucocorticoids KW - 0 KW - Aspirin KW - R16CO5Y76E KW - Index Medicus KW - Hypersensitivity -- complications KW - Genotype KW - Pulmonary Ventilation -- physiology KW - Aspirin -- adverse effects KW - Humans KW - Glucocorticoids -- adverse effects KW - Genetic Predisposition to Disease KW - Phenotype KW - Asthma -- etiology KW - Asthma -- genetics KW - Asthma -- physiopathology KW - Asthma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68359974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+pulmonary+medicine&rft.atitle=Asthma+phenotypes.&rft.au=Kiley%2C+James%3BSmith%2C+Robert%3BNoel%2C+Patricia&rft.aulast=Kiley&rft.aufirst=James&rft.date=2007-01-01&rft.volume=13&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+pulmonary+medicine&rft.issn=10705287&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2006-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetics, biology and clinical management of myeloid cell primary immune deficiencies: chronic granulomatous disease and leukocyte adhesion deficiency. AN - 68357553; 17133097 AB - Chronic granulomatous disease and leukocyte adhesion deficiency are the major primary immune deficiencies affecting phagocytic blood cells. Major advances in clinical diagnosis and development of novel treatments for these disorders merit review. Clinically beneficial gene therapy correction of X-linked chronic granulomatous disease in two adult patients was reported. Nonmyeloablative busulfan conditioning before administration of gene corrected autologous hematopoietic stem cells was likely an essential maneuver to achieve successful gene therapy. There is an increased association of autoimmune disorders with chronic granulomatous disease. Preimplantation genetic diagnosis of leukocyte adhesion deficiency-I led to the birth of a normal child. A canine model of leukocyte adhesion deficiency-I facilitated development of new nonmyeloablative hematopoietic stem cell transplant and gene therapy approaches to leukocyte adhesion deficiency. Nonmyeloablative transplantation may provide an effective, but less toxic approach for leukocyte adhesion deficiency in children. There have been advances in understanding the basis of leukocyte adhesion deficiency-II and III. The most important subjects reviewed in this chapter include new advances in development of gene therapy for chronic granulomatous disease and leukocyte adhesion deficiency-I; transplantation for leukocyte adhesion deficiency-I; prenatal diagnosis of leukocyte adhesion deficiency-I; and association of autoimmune diseases with chronic granulomatous disease. JF - Current opinion in hematology AU - Malech, Harry L AU - Hickstein, Dennis D AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20982-1456, USA. hmalech@nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 29 EP - 36 VL - 14 IS - 1 SN - 1065-6251, 1065-6251 KW - Index Medicus KW - Models, Animal KW - Animals KW - Humans KW - Hematopoietic Stem Cell Transplantation KW - Dogs KW - Preimplantation Diagnosis KW - Female KW - Pregnancy KW - Neutrophils -- immunology KW - Leukocyte-Adhesion Deficiency Syndrome -- genetics KW - Genetic Therapy -- methods KW - Granulomatous Disease, Chronic -- therapy KW - Granulomatous Disease, Chronic -- genetics KW - Leukocyte-Adhesion Deficiency Syndrome -- diagnosis KW - Leukocyte-Adhesion Deficiency Syndrome -- therapy KW - Granulomatous Disease, Chronic -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68357553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+opinion+in+hematology&rft.atitle=Genetics%2C+biology+and+clinical+management+of+myeloid+cell+primary+immune+deficiencies%3A+chronic+granulomatous+disease+and+leukocyte+adhesion+deficiency.&rft.au=Malech%2C+Harry+L%3BHickstein%2C+Dennis+D&rft.aulast=Malech&rft.aufirst=Harry&rft.date=2007-01-01&rft.volume=14&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Current+opinion+in+hematology&rft.issn=10656251&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-23 N1 - Date created - 2006-11-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stage-specific alterations of the genome, transcriptome, and proteome during colorectal carcinogenesis. AN - 68356157; 17044061 AB - To identify sequential alterations of the genome, transcriptome, and proteome during colorectal cancer progression, we have analyzed tissue samples from 36 patients, including the complete mucosa-adenoma-carcinoma sequence from 8 patients. Comparative genomic hybridization (CGH) revealed patterns of stage specific, recurrent genomic imbalances. Gene expression analysis on 9K cDNA arrays identified 58 genes differentially expressed between normal mucosa and adenoma, 116 genes between adenoma and carcinoma, and 158 genes between primary carcinoma and liver metastasis (P < 0.001). Parallel analysis of our samples by CGH and expression profiling revealed a direct correlation of chromosomal copy number changes with chromosome-specific average gene expression levels. Protein expression was analyzed by two-dimensional gel electrophoresis and subsequent mass spectrometry. Although there was no direct match of differentially expressed proteins and genes, the majority of them belonged to identical pathways or networks. In conclusion, increasing genomic instability and a recurrent pattern of chromosomal imbalances as well as specific gene and protein expression changes correlate with distinct stages of colorectal cancer progression. Chromosomal aneuploidies directly affect average resident gene expression levels, thereby contributing to a massive deregulation of the cellular transcriptome. The identification of novel genes and proteins might deliver molecular targets for diagnostic and therapeutic interventions. Copyright Wiley-Liss, Inc. JF - Genes, chromosomes & cancer AU - Habermann, Jens K AU - Paulsen, Ulrike AU - Roblick, Uwe J AU - Upender, Madhvi B AU - McShane, Lisa M AU - Korn, Edward L AU - Wangsa, Danny AU - Krüger, Stefan AU - Duchrow, Michael AU - Bruch, Hans-Peter AU - Auer, Gert AU - Ried, Thomas AD - Genetics Branch, National Cancer Institute, NIH, Bethesda, MD 20892-8010, USA. habermaj@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 10 EP - 26 VL - 46 IS - 1 SN - 1045-2257, 1045-2257 KW - Proteome KW - 0 KW - Index Medicus KW - Gene Expression Profiling KW - Aneuploidy KW - Oligonucleotide Array Sequence Analysis KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Models, Biological KW - Male KW - Female KW - Proteome -- genetics KW - Gene Expression Regulation, Neoplastic KW - Genome, Human KW - Colorectal Neoplasms -- metabolism KW - Proteome -- metabolism KW - Transcription, Genetic KW - Colorectal Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68356157?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genes%2C+chromosomes+%26+cancer&rft.atitle=Stage-specific+alterations+of+the+genome%2C+transcriptome%2C+and+proteome+during+colorectal+carcinogenesis.&rft.au=Habermann%2C+Jens+K%3BPaulsen%2C+Ulrike%3BRoblick%2C+Uwe+J%3BUpender%2C+Madhvi+B%3BMcShane%2C+Lisa+M%3BKorn%2C+Edward+L%3BWangsa%2C+Danny%3BKr%C3%BCger%2C+Stefan%3BDuchrow%2C+Michael%3BBruch%2C+Hans-Peter%3BAuer%2C+Gert%3BRied%2C+Thomas&rft.aulast=Habermann&rft.aufirst=Jens&rft.date=2007-01-01&rft.volume=46&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Genes%2C+chromosomes+%26+cancer&rft.issn=10452257&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-29 N1 - Date created - 2006-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Experimental determination of calibration settings of a commercially available radionuclide calibrator for various clinical measurement geometries and radionuclides. AN - 68355471; 16996744 AB - Following the approach of the National Primary Laboratory of the UK (NPL) for the calibration of radionuclide calibrators, but using a commercially available instrument with no data available in the literature, the radionuclide calibrator response was investigated as a function of different measurement geometries at the "Regina Elena" National Cancer Institute (IRE) in Rome. Working with Italian National Metrology Institute for ionising radiation quantities (ENEA-INMRI), specific calibration factors with traceability to national primary standards were determined for different types of glass vials, solid capsules and plastic syringes, investigating three radionuclides with different energy spectra (Tc-99m, In-111, I-131). For each kind of syringe, calibration correction factors for different filling volumes were calculated. For Tc-99m and I-131 the difference between measured and true activity was in the range 2-7%, depending on measurement geometry. For In-111 a large percentage deviation from the true activity value was found in each geometry considered, reaching 35%. The magnitude of this difference is particularly dependent on the energies of the emitted photons. JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine AU - Ceccatelli, A AU - Benassi, M AU - D'Andrea, M AU - De Felice, P AU - Fazio, A AU - Nocentini, S AU - Strigari, L AD - Laboratorio di Fisica Medica e Sistemi Esperti, Regina Elena National Cancer Institute, via E. Chianesi, 53 - 00144 Rome, Italy. alessia.ceccatelli@tiscali.it Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 120 EP - 125 VL - 65 IS - 1 SN - 0969-8043, 0969-8043 KW - Radioisotopes KW - 0 KW - Radiopharmaceuticals KW - Index Medicus KW - Sensitivity and Specificity KW - Radiation Dosage KW - Reference Values KW - European Union KW - Reproducibility of Results KW - Reference Standards KW - Calibration KW - Radiopharmaceuticals -- analysis KW - Radiometry -- instrumentation KW - Radioisotopes -- standards KW - Guidelines as Topic KW - Radiopharmaceuticals -- standards KW - Radioisotopes -- analysis KW - Radiometry -- standards UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68355471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.atitle=Experimental+determination+of+calibration+settings+of+a+commercially+available+radionuclide+calibrator+for+various+clinical+measurement+geometries+and+radionuclides.&rft.au=Ceccatelli%2C+A%3BBenassi%2C+M%3BD%27Andrea%2C+M%3BDe+Felice%2C+P%3BFazio%2C+A%3BNocentini%2C+S%3BStrigari%2C+L&rft.aulast=Ceccatelli&rft.aufirst=A&rft.date=2007-01-01&rft.volume=65&rft.issue=1&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Applied+radiation+and+isotopes+%3A+including+data%2C+instrumentation+and+methods+for+use+in+agriculture%2C+industry+and+medicine&rft.issn=09698043&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-11-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular genetic structure-function analysis of translation initiation factor eIF5B. AN - 68343003; 17913624 AB - Recently, significant progress has been made in obtaining three-dimensional (3-D) structures of the factors that promote translation initiation, elongation, and termination. These structures, when interpreted in light of previous biochemical characterizations of the factors, provide significant insight into the function of the factors and the molecular mechanism of specific steps in the translation process. In addition, genetic analyses in yeast have helped elucidate the in vivo roles of the factors in various steps of the translation pathway. We have combined these two approaches and use molecular genetic studies to define the structure-function properties of translation initiation factors in the yeast Saccharomyces cerevisiae. In this chapter, we describe our multistep approach in which we first characterize a site-directed mutant of the factor of interest using in vivo and in vitro assays of protein synthesis. Next, we subject the mutant gene to random mutagenesis and screen for second-site mutations that restore the factor's function in vivo. Following biochemical and in vivo characterization of the suppressor mutant, we interpret the results in light of the 3-D structure of the factor to define the structure-function properties of the factor and to provide new molecular insights into the mechanism of translation. JF - Methods in enzymology AU - Shin, Byung-Sik AU - Dever, Thomas E AD - Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 185 EP - 201 VL - 429 SN - 0076-6879, 0076-6879 KW - Cell Extracts KW - 0 KW - Eukaryotic Initiation Factor-2 KW - Eukaryotic Initiation Factors KW - FUN12 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - eukaryotic initiation factor-5B KW - GTP Phosphohydrolases KW - EC 3.6.1.- KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Cell Fractionation KW - Saccharomyces cerevisiae Proteins -- genetics KW - Suppression, Genetic -- genetics KW - Polyribosomes -- physiology KW - GTP Phosphohydrolases -- analysis KW - Eukaryotic Initiation Factor-2 -- genetics KW - Ribosomes -- physiology KW - Saccharomyces cerevisiae -- genetics KW - Eukaryotic Initiation Factors -- chemistry KW - Eukaryotic Initiation Factors -- physiology KW - Eukaryotic Initiation Factors -- genetics KW - Saccharomyces cerevisiae -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68343003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+enzymology&rft.atitle=Molecular+genetic+structure-function+analysis+of+translation+initiation+factor+eIF5B.&rft.au=Shin%2C+Byung-Sik%3BDever%2C+Thomas+E&rft.aulast=Shin&rft.aufirst=Byung-Sik&rft.date=2007-01-01&rft.volume=429&rft.issue=&rft.spage=185&rft.isbn=&rft.btitle=&rft.title=Methods+in+enzymology&rft.issn=00766879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-12-03 N1 - Date created - 2007-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Osmotic stress and DNA damage. AN - 68286132; 17875421 AB - Mammalian renal inner medullary cells are normally exposed to extremely high NaCl concentrations. The interstitial NaCl concentration in parts of a normal renal medulla can be 500 mM or more, depending on the species. Remarkably, under these normal conditions, the high NaCl causes DNA damage, yet the cells survive and function both in cell culture and in vivo. Both in cell culture and in vivo the breaks are repaired rapidly if the NaCl concentration is lowered. This chapter describes two methods used to detect and study the DNA damage induced by osmotic stress: comet assay or single cell electrophoresis and TUNEL assay or in situ labeling of 3'-OH ends of DNA strands. This chapter also discusses how specifics of the protocols influence the conclusions about types of DNA damage and what the limitations of these methods are for detecting different types of DNA damage. JF - Methods in enzymology AU - Dmitrieva, Natalia I AU - Burg, Maurice B AD - Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 241 EP - 252 VL - 428 SN - 0076-6879, 0076-6879 KW - Index Medicus KW - Comet Assay -- methods KW - In Situ Nick-End Labeling -- methods KW - DNA Damage -- physiology KW - Osmotic Pressure KW - Apoptosis -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68286132?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+in+enzymology&rft.atitle=Osmotic+stress+and+DNA+damage.&rft.au=Dmitrieva%2C+Natalia+I%3BBurg%2C+Maurice+B&rft.aulast=Dmitrieva&rft.aufirst=Natalia&rft.date=2007-01-01&rft.volume=428&rft.issue=&rft.spage=241&rft.isbn=&rft.btitle=&rft.title=Methods+in+enzymology&rft.issn=00766879&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-05 N1 - Date created - 2007-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intentional exposure studies of environmental agents on human subjects: assessing benefits and risks. AN - 68261529; 17847606 AB - In this article, I assess the benefits and risks of studies that intentionally expose research subjects to environmental agents. I describe these types of studies, identify their benefits and risks, compare them to other research methods that can be used to investigate the relationship between environmental exposures and disease, and discuss some issues related to research design and risk minimization. I argue that the benefits of intentional environmental exposure studies outweigh the risks when 1) the knowledge gained is likely to improve our understanding of the relationship between environmental exposure and disease, 2) this knowledge cannot be obtained by other methods, 3) the experiments are well designed, 4) the subjects will receive some benefits, such as medical evaluations, 5) risks are minimized, and 6) the risks to human subjects are less than those encountered in a typical Phase I drug study. Only in rare circumstances (i.e., when an intentional environmental exposure study is needed to implement an important environmental or public health intervention or regulation) may such studies expose research subjects to risks as high as those encountered in a typical Phase I drug trail. JF - Accountability in research AU - Resnik, David B AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. resnikd@niehs.nih.gov PY - 2007 SP - 35 EP - 55 VL - 14 IS - 1 SN - 0898-9621, 0898-9621 KW - Pesticides KW - 0 KW - Bioethics KW - Index Medicus KW - United States KW - Animals KW - Humans KW - United States Environmental Protection Agency -- ethics KW - Risk Assessment -- ethics KW - Environmental Exposure -- ethics KW - Environmental Exposure -- adverse effects KW - Ethics, Research KW - Pesticides -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68261529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accountability+in+research&rft.atitle=Intentional+exposure+studies+of+environmental+agents+on+human+subjects%3A+assessing+benefits+and+risks.&rft.au=Resnik%2C+David+B&rft.aulast=Resnik&rft.aufirst=David&rft.date=2007-01-01&rft.volume=14&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Accountability+in+research&rft.issn=08989621&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-27 N1 - Date created - 2007-09-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Contemp Health Law Policy. 2000 Summer;16(2):427-58 [10921235] Environ Health Perspect. 2004 Mar;112(3):A150-1; author reply A151-2; discussion A152-6 [14998762] Environ Health Perspect. 2004 Feb;112(2):142-7 [14754567] J Natl Med Assoc. 2002 Oct;94(10 Suppl):1-26 [12401060] Environ Health Perspect. 2004 Jun;112(8):914-9 [15175182] Ann Neurol. 2006 Aug;60(2):197-203 [16802290] JAMA. 2000 May 24-31;283(20):2701-11 [10819955] Am J Bioeth. 2006 May-Jun;6(3):W1-13 [16754430] N Engl J Med. 2006 May 4;354(18):1869-71 [16672696] Environ Health Perspect. 2004 Jun;112(8):A458-9 [15175189] Environ Health Perspect. 2004 Sep;112(13):1275-81 [15345339] Am J Public Health. 2004 Nov;94(11):1908-16 [15514226] Environ Health Perspect. 1993 Oct;101(5):396-401 [8119247] Regul Toxicol Pharmacol. 1995 Feb;21(1):75-80; discussion 81-6 [7784639] Arch Toxicol. 2004 Oct;78(10):565-74 [15150681] J Nutr. 2005 Feb;135(2):283-6 [15671227] Environ Health Perspect. 2005 Jul;113(7):813-7 [16002367] Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:143-6 [16092721] JAMA. 2005 Aug 17;294(7):826-32 [16106008] Environ Health Perspect. 2006 Feb;114(2):209-12 [16451856] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - New approaches for monitoring CTL activity in clinical trials. AN - 68196300; 17713015 AB - We have developed a modification of the ELISPOT assay that measures Granzyme B (GrB) release from cytotoxic T lymphocytes (CTLs). The GrB ELISPOT assay is a superior alternative to the 51Cr-release assay since it is significantly more sensitive and provides an estimation of cytotoxic effector cell frequency. Additionally, unlike the IFN-gamma ELISPOT assay, the GrB ELISPOT directly measures the release of a cytolytic protein. We report that the GrB ELISPOT can be utilized to measure ex vivo antigen-specific cytotoxicity of peripheral blood mononuclear cells (PBMCs) from cancer patients vaccinated with a peptide-based cancer vaccine. We compare the reactivity of patients' PBMCs in the GrB ELISPOT, with reactivity in the tetramer, IFN-gamma ELISPOT and chromium (51Cr)-release assays. Differences in immune response over all assays tested were found between patients, and four response patterns were observed. Reactivity in the GrB ELISPOT was more closely associated with cytotoxicity in the 51Cr-release assay than the tetramer or IFN-gamma ELISPOT assays. We also optimized the GrB ELISPOT assay to directly measure immune responses against autologous primary tumor cells in vaccinated cancer patients. A perforin ELISPOT assay was also adapted to evaluate peptide-stimulated reactivity of PMBCs from vaccinated melanoma patients. Modifications of the ELISPOT assay described in this chapter allow a more comprehensive evaluation of low-frequency tumor-specific CTLs and their specific effector functions and can provide a valuable insight into immune responses in cancer vaccine trials. JF - Advances in experimental medicine and biology AU - Malyguine, Anatoli AU - Strobl, Susan AU - Zaritskaya, Liubov AU - Baseler, Michael AU - Shafer-Weaver, Kimberly AD - Applied and Developmental Research Support Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD, USA. amalyguine@ncifcrf.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 273 EP - 284 VL - 601 SN - 0065-2598, 0065-2598 KW - Cancer Vaccines KW - 0 KW - Chromium Radioisotopes KW - Membrane Glycoproteins KW - Pore Forming Cytotoxic Proteins KW - Perforin KW - 126465-35-8 KW - Granzymes KW - EC 3.4.21.- KW - Index Medicus KW - Membrane Glycoproteins -- chemistry KW - Cytotoxicity Tests, Immunologic -- methods KW - Animals KW - Cancer Vaccines -- chemistry KW - Humans KW - Granzymes -- chemistry KW - Chromium Radioisotopes -- chemistry KW - Pore Forming Cytotoxic Proteins -- chemistry KW - Immune System KW - Enzyme-Linked Immunosorbent Assay -- methods KW - T-Lymphocytes, Cytotoxic -- cytology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68196300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Advances+in+experimental+medicine+and+biology&rft.atitle=New+approaches+for+monitoring+CTL+activity+in+clinical+trials.&rft.au=Malyguine%2C+Anatoli%3BStrobl%2C+Susan%3BZaritskaya%2C+Liubov%3BBaseler%2C+Michael%3BShafer-Weaver%2C+Kimberly&rft.aulast=Malyguine&rft.aufirst=Anatoli&rft.date=2007-01-01&rft.volume=601&rft.issue=&rft.spage=273&rft.isbn=&rft.btitle=&rft.title=Advances+in+experimental+medicine+and+biology&rft.issn=00652598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-10-03 N1 - Date created - 2007-08-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An immortalized rat ventral mesencephalic cell line, RTC4, is protective in a rodent model of stroke. AN - 68182322; 17708338 AB - One therapeutic approach to stroke is the transplantation of cells capable of trophic support, reinnervation, and/or regeneration. Previously, we have described the use of novel truncated isoforms of SV40 large T antigen to generate unique cell lines from several primary rodent tissue types. Here we describe the generation of two cell lines, RTC3 and RTC4, derived from primary mesencephalic tissue using a fragment of mutant T antigen, T155c (cDNA) expressed from the RSV promoter. Both lines expressed the glial markers vimentin and S100beta, but not the neuronal markers NeuN, MAP2, or beta-III-tubulin. A screen for secreted trophic factors revealed substantially elevated levels of platelet-derived growth factor (PDGF) in RTC4, but not RTC3 cells. When transplanted into rat cortex, RTC4 cells survived for at least 22 days and expressed PDGF. Because PDGF has been reported to reduce ischemic injury, we examined the protective functions of RTC4 cells in an animal model of stroke. RTC4 or RTC3 cells, or vehicle, were injected into rat cortex 15-20 min prior to a 60-min middle cerebral artery ligation. Forty-eight hours later, animals were sacrificed and the stroke volume was assessed by triphenyl-tetrazolium chloride (TTC) staining. Compared to vehicle or RTC3 cells, transplanted RTC4 cells significantly reduced stroke volume. Overall, we generated a cell line with glial properties that produces PDGF and reduces ischemic injury in a rat model of stroke. JF - Cell transplantation AU - Harvey, B K AU - Chen, G J AU - Schoen, C J AU - Lee, C T AU - Howard, D B AU - Dillon-Carter, O AU - Coggiano, M AU - Freed, W J AU - Wang, Y AU - Hoffer, B J AU - Sanchez, J F AD - Molecular Neuropsychiatry Research Branch, National Institute on Drug Abuse, National Institutes of Health (NIH), Baltimore, MD 21224, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 483 EP - 491 VL - 16 IS - 5 SN - 0963-6897, 0963-6897 KW - Growth Substances KW - 0 KW - Platelet-Derived Growth Factor KW - Index Medicus KW - Rats KW - Phenotype KW - Animals KW - Rats, Sprague-Dawley KW - Growth Substances -- secretion KW - Cell Death KW - Cerebral Infarction -- prevention & control KW - Platelet-Derived Growth Factor -- secretion KW - Disease Models, Animal KW - Cell Line, Transformed KW - Male KW - Cerebral Infarction -- chemically induced KW - Cell Survival KW - Mesencephalon -- transplantation KW - Stroke -- prevention & control KW - Mesencephalon -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+transplantation&rft.atitle=An+immortalized+rat+ventral+mesencephalic+cell+line%2C+RTC4%2C+is+protective+in+a+rodent+model+of+stroke.&rft.au=Harvey%2C+B+K%3BChen%2C+G+J%3BSchoen%2C+C+J%3BLee%2C+C+T%3BHoward%2C+D+B%3BDillon-Carter%2C+O%3BCoggiano%2C+M%3BFreed%2C+W+J%3BWang%2C+Y%3BHoffer%2C+B+J%3BSanchez%2C+J+F&rft.aulast=Harvey&rft.aufirst=B&rft.date=2007-01-01&rft.volume=16&rft.issue=5&rft.spage=483&rft.isbn=&rft.btitle=&rft.title=Cell+transplantation&rft.issn=09636897&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-07 N1 - Date created - 2007-08-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Brain Res Mol Brain Res. 2003 May 12;113(1-2):44-51 [12750005] J Neurosci. 2003 Aug 27;23(21):7958-65 [12944527] Exp Neurol. 2003 Sep;183(1):47-55 [12957487] Gene Ther. 2003 Dec;10(26):2105-11 [14625564] Cell Transplant. 2004;13(3):319-27 [15191169] Kobe J Med Sci. 2004 Jan;50(1-2):21-30 [15342968] Proc Natl Acad Sci U S A. 1978 May;75(5):2473-7 [209467] Mol Cell Biol. 1986 Apr;6(4):1172-8 [3023875] Cell. 1987 Jan 30;48(2):321-30 [3026642] J Virol. 1992 Mar;66(3):1289-93 [1310750] Exp Neurol. 1993 Dec;124(2):368-71 [8287932] Exp Neurol. 1993 Dec;124(2):401-12 [7904571] Cell Transplant. 1993 Mar-Apr;2(2):151-62 [7908247] Brain Res. 1994 Apr 18;643(1-2):162-72 [8032912] Brain Res. 2001 May 11;900(2):268-76 [11334807] J Cereb Blood Flow Metab. 1999 Dec;19(12):1329-35 [10598937] Cancer Lett. 2003 Mar 20;192(1):97-107 [12637158] Exp Neurol. 2002 Jun;175(2):318-37 [12061863] Exp Neurol. 1994 Aug;128(2):191-201 [8076662] J Virol. 1998 Mar;72(3):2224-32 [9499080] Metab Brain Dis. 1997 Dec;12(4):271-80 [9475500] Cell Tissue Res. 1998 Feb;291(2):175-89 [9426306] J Cereb Blood Flow Metab. 1997 Oct;17(10):1097-106 [9346435] J Cereb Blood Flow Metab. 1997 May;17(5):500-6 [9183287] J Neurosci. 1997 Jun 1;17(11):4341-8 [9151750] J Mol Neurosci. 2005;27(2):245-60 [16186635] J Neurosurg. 2005 Jul;103(1):38-45 [16121971] Brain Res. 1999 Sep 18;842(1):211-4 [10526112] Stroke. 1998 Jul;29(7):1417-22 [9660398] Brain Res. 1998 Feb 16;784(1-2):250-5 [9518639] Neurosci Res. 1997 Dec;29(4):335-43 [9527625] Stroke. 1997 Mar;28(3):564-73 [9056612] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trastuzumab in the adjuvant treatment of breast cancer. AN - 68142515; 17685010 AB - Four large randomized trials to assess efficacy and toxicity of trastuzumab in adjuvant systemic therapy of breast cancer have been initiated. Results clearly demonstrate, that adjuvant treatment of trastuzumab significantly improves outcomes for women with HER2 positive breast cancer. The clinically most significant adverse events of trastuzumab are serious-infusion related reactions and cardiotoxicity. Benefit for patient should be considered according to advantage versus risk (Tab. 1, Fig. 2, Ref. 17) Full Text (Free, PDF) www.bmj.sk. JF - Bratislavske lekarske listy AU - Svetlovska, D AU - Mardiak, J AU - Kristova, V AD - National Cancer Institute, Bratislava, Slovakia. daniela.svetlovska@nou.sk Y1 - 2007 PY - 2007 DA - 2007 SP - 100 EP - 103 VL - 108 IS - 2 SN - 0006-9248, 0006-9248 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Trastuzumab KW - P188ANX8CK KW - Index Medicus KW - Humans KW - Female KW - Chemotherapy, Adjuvant KW - Breast Neoplasms -- drug therapy KW - Antineoplastic Agents -- therapeutic use KW - Antibodies, Monoclonal -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68142515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bratislavske+lekarske+listy&rft.atitle=Trastuzumab+in+the+adjuvant+treatment+of+breast+cancer.&rft.au=Svetlovska%2C+D%3BMardiak%2C+J%3BKristova%2C+V&rft.aulast=Svetlovska&rft.aufirst=D&rft.date=2007-01-01&rft.volume=108&rft.issue=2&rft.spage=100&rft.isbn=&rft.btitle=&rft.title=Bratislavske+lekarske+listy&rft.issn=00069248&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-18 N1 - Date created - 2007-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds. AN - 68110872; 17665847 AB - Four new ethylnitrosourea derivatives of substituted naphthalimides 3a-d have been synthesized from the respective N-(2-ethylamino) naphthalimides. Their chemical alkylating activity compared with the clinical drug CCNU and an experimental compound Mitonafide indicated that they possess lower alkylating activity than CCNU and comparable activity with the latter. Their anti-tumor efficacies were assessed in vivo in two murine ascites tumors namely Sarcoma-180 (S-180) and Ehrlich ascites carcinoma (EAC) by measuring the increase in median survival times (MST) of drug treated (T) over untreated control (C) mice. CCNU and Mitonafide were used as positive controls for comparison. The representative compound 3a has displayed marginal anti-tumoral activity in these tumors. Three compounds were further screened in vitro in 4 different human tumor cell lines but no significant activity was observed in those lines. These compounds moderately inhibit the synthesis of DNA and RNA in S-180 tumor cells. JF - Acta poloniae pharmaceutica AU - Pain, Anindita AU - Samanta, Suva AU - Dutta, Sushanta AU - Saxena, Ajit K AU - Shanmugavel, Mutiah AU - Sharma, Madhunika AU - Qazi, Gulam N AU - Sanyal, Utpal AD - Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata - 700026, India. PY - 2007 SP - 27 EP - 33 VL - 64 IS - 1 SN - 0001-6837, 0001-6837 KW - Antineoplastic Agents, Alkylating KW - 0 KW - Imides KW - Isoquinolines KW - Naphthalimides KW - Nitrosourea Compounds KW - mitonafide KW - 06Q0V17SI9 KW - RNA KW - 63231-63-0 KW - Lomustine KW - 7BRF0Z81KG KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Animals KW - Drug Screening Assays, Antitumor KW - Dose-Response Relationship, Drug KW - Humans KW - Lomustine -- pharmacology KW - Cell Line, Tumor KW - Imides -- pharmacology KW - Mice KW - DNA -- biosynthesis KW - RNA -- drug effects KW - Structure-Activity Relationship KW - DNA -- drug effects KW - RNA -- biosynthesis KW - Isoquinolines -- pharmacology KW - Nitrosourea Compounds -- pharmacology KW - Nitrosourea Compounds -- chemistry KW - Antineoplastic Agents, Alkylating -- chemical synthesis KW - Antineoplastic Agents, Alkylating -- pharmacology KW - Naphthalimides -- chemistry KW - Sarcoma 180 -- drug therapy KW - Nitrosourea Compounds -- chemical synthesis KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Nitrosourea Compounds -- administration & dosage KW - Naphthalimides -- chemical synthesis KW - Antineoplastic Agents, Alkylating -- chemistry KW - Naphthalimides -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110872?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+poloniae+pharmaceutica&rft.atitle=Synthesis+and+evaluation+of+ethylnitrosoureas+of+substituted+naphthalimides+as+anticancer+compounds.&rft.au=Pain%2C+Anindita%3BSamanta%2C+Suva%3BDutta%2C+Sushanta%3BSaxena%2C+Ajit+K%3BShanmugavel%2C+Mutiah%3BSharma%2C+Madhunika%3BQazi%2C+Gulam+N%3BSanyal%2C+Utpal&rft.aulast=Pain&rft.aufirst=Anindita&rft.date=2007-01-01&rft.volume=64&rft.issue=1&rft.spage=27&rft.isbn=&rft.btitle=&rft.title=Acta+poloniae+pharmaceutica&rft.issn=00016837&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-30 N1 - Date created - 2007-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans. AN - 68095240; 17472752 AB - Caenorhabditis elegans is an important model for the study of DNA damage and repair related processes such as aging, neurodegeneration, and carcinogenesis. However, DNA repair is poorly characterized in this organism. We adapted a quantitative polymerase chain reaction assay to characterize repair of DNA damage induced by ultraviolet type C (UVC) radiation in C. elegans, and then tested whether DNA repair rates were affected by age in adults. UVC radiation induced lesions in young adult C. elegans, with a slope of 0.4 to 0.5 lesions per 10 kilobases of DNA per 100 J/m2, in both nuclear and mitochondrial targets. L1 and dauer larvae were more than fivefold more sensitive to lesion formation than were young adults. Nuclear repair kinetics in a well expressed nuclear gene were biphasic in nongravid adult nematodes: a faster, first order (half-life about 16 hours) phase lasting approximately 24 hours and resulting in removal of about 60% of the photoproducts was followed by a much slower phase. Repair in ten nuclear DNA regions was 15% and 50% higher in more actively transcribed regions in young and aging adults, respectively. Finally, repair was reduced by 30% to 50% in each of the ten nuclear regions in aging adults. However, this decrease in repair could not be explained by a reduction in expression of nucleotide excision repair genes, and we present a plausible mechanism, based on gene expression data, to account for this decrease. Repair of UVC-induced DNA damage in C. elegans is similar kinetically and genetically to repair in humans. Furthermore, this important repair process slows significantly in aging C. elegans, the first whole organism in which this question has been addressed. JF - Genome biology AU - Meyer, Joel N AU - Boyd, Windy A AU - Azzam, Gregory A AU - Haugen, Astrid C AU - Freedman, Jonathan H AU - Van Houten, Bennett AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Alexander Drive, Research Triangle Park, NC 27709, USA. joel.meyer@duke.edu Y1 - 2007 PY - 2007 DA - 2007 SP - 1 VL - 8 IS - 5 KW - Index Medicus KW - Polymerase Chain Reaction KW - Animals KW - DNA Damage KW - Kinetics KW - Caenorhabditis elegans KW - Ultraviolet Rays -- adverse effects KW - DNA Repair -- physiology KW - Aging -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68095240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+biology&rft.atitle=Decline+of+nucleotide+excision+repair+capacity+in+aging+Caenorhabditis+elegans.&rft.au=Meyer%2C+Joel+N%3BBoyd%2C+Windy+A%3BAzzam%2C+Gregory+A%3BHaugen%2C+Astrid+C%3BFreedman%2C+Jonathan+H%3BVan+Houten%2C+Bennett&rft.aulast=Meyer&rft.aufirst=Joel&rft.date=2007-01-01&rft.volume=8&rft.issue=5&rft.spage=R70&rft.isbn=&rft.btitle=&rft.title=Genome+biology&rft.issn=1474-760X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-07-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Bioessays. 2003 Feb;25(2):168-73 [12539243] Genes Dev. 2003 Feb 15;17(4):443-8 [12600937] Nat Rev Genet. 2003 Mar;4(3):181-94 [12610523] Science. 2003 Feb 28;299(5611):1355-9 [12610296] Genome Biol. 2003;4(4):R28 [12702209] Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10670-5 [12960370] Cell Death Differ. 2004 Jan;11(1):21-8 [14685168] Exp Gerontol. 2003 Nov-Dec;38(11-12):1329-32 [14698813] Curr Biol. 2004 Jan 6;14(1):33-9 [14711411] Nat Genet. 2004 Feb;36(2):197-204 [14730301] Aging Cell. 2004 Apr;3(2):55-65 [15038819] Development. 2004 Jun;131(11):2565-75 [15115755] J Gerontol. 1988 Sep;43(5):B137-41 [3418030] Toxicol Ind Health. 1988 Dec;4(4):469-78 [3188044] Mutat Res. 1988 Nov-Dec;209(3-4):99-106 [3193983] Nucleic Acids Res. 1989 Jun 26;17(12):4433-9 [2664708] Genetics. 1989 Jun;122(2):379-85 [2767423] Photochem Photobiol. 1989 Jun;49(6):805-19 [2672059] EMBO J. 1990 Sep;9(9):2899-904 [2202594] Mutat Res. 1991 Sep;255(2):163-73 [1922148] Genetics. 1992 Mar;130(3):471-98 [1551572] J Biol Chem. 1992 Jun 15;267(17):12182-7 [1601884] Photochem Photobiol. 1992 Jan;55(1):103-11 [1603841] Mol Biol Cell. 1992 Nov;3(11):1199-213 [1457827] Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1614-8 [8434025] Nucleic Acids Res. 1994 Nov 25;22(23):4937-42 [7800483] Genome Biol. 2006;7 Suppl 1:S12.1-14 [16925834] DNA Repair (Amst). 2004 Oct 5;3(10):1375-83 [15336632] Cell Death Differ. 2004 Nov;11(11):1198-203 [15272318] Proc Natl Acad Sci U S A. 1979 Mar;76(3):1333-7 [286315] Genetics. 1980 Sep;96(1):147-64 [6894129] Genetics. 1982 Oct;102(2):159-78 [7152245] Mech Ageing Dev. 1983 Jul-Aug;22(3-4):253-63 [6355679] Photochem Photobiol. 1984 Feb;39(2):169-75 [6709723] Mutat Res. 1984 Sep-Oct;132(3-4):95-9 [6493262] J Biol Chem. 1986 Dec 15;261(35):16666-72 [3023360] Mutat Res. 1988 Jun;208(2):77-82 [3380112] Exp Cell Res. 2000 Apr 10;256(1):308-14 [10739678] Proc Natl Acad Sci U S A. 2000 May 9;97(10):5285-90 [10805788] Mutat Res. 2000 May 30;450(1-2):19-40 [10838132] Gene. 2000 May 30;250(1-2):15-30 [10854775] FASEB J. 2000 Jul;14(10):1325-34 [10877825] Mol Cell. 2000 Mar;5(3):435-43 [10882129] Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):258-62 [7816828] Photochem Photobiol. 1996 Feb;63(2):187-92 [8657732] Mutat Res. 1996 Oct 18;364(2):117-23 [8879277] J Biol Chem. 1998 Nov 27;273(48):31962-70 [9822667] Exp Cell Res. 1998 Nov 25;245(1):228-38 [9828120] Curr Biol. 1999 May 6;9(9):493-6 [10330373] Mutat Res. 1999 Jul 30;434(3):161-76 [10486590] Oncogene. 2004 Nov 1;23(51):8340-5 [15517014] Oncogene. 2004 Nov 1;23(51):8366-75 [15517018] Genome Biol. 2004;5(12):R95 [15575969] FEBS Lett. 2005 Feb 7;579(4):873-6 [15680966] Cell. 2005 Feb 25;120(4):449-60 [15734678] Cell. 2005 Feb 25;120(4):497-512 [15734682] Aging Cell. 2005 Apr;4(2):87-95 [15771612] Genes Dev. 2005 Jul 1;19(13):1544-55 [15998808] Comp Biochem Physiol B Biochem Mol Biol. 2005 Aug;141(4):453-60 [15979372] Oncogene. 2005 Jul 28;24(32):5026-42 [15897889] Bioinformatics. 2005 Aug 15;21(16):3448-9 [15972284] Mutat Res. 2005 Sep 4;577(1-2):252-9 [15916783] Arch Dermatol Res. 2006 Jan;297(7):294-302 [16328344] Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1727-31 [16443681] Science. 2006 Mar 10;311(5766):1481-4 [16527984] Cell Struct Funct. 2006;31(1):29-37 [16565574] Bioinformatics. 2006 May 1;22(9):1111-21 [16522673] Methods Mol Biol. 2006;314:183-99 [16673882] Neurobiol Aging. 2006 Aug;27(8):1129-36 [16005114] Mutat Res. 2000 Jul 25;460(2):81-94 [10882849] Mol Gen Genet. 2000 Sep;264(1-2):119-26 [11016841] Methods. 2000 Oct;22(2):135-47 [11020328] Exp Gerontol. 2000 Sep;35(6-7):687-94 [11053658] Science. 2000 Oct 27;290(5492):809-12 [11052945] Exp Gerontol. 2001 Jul;36(7):1049-62 [11404050] J Biol Chem. 2001 Nov 9;276(45):41553-8 [11527963] Arch Biochem Biophys. 2001 Nov 15;395(2):158-68 [11697852] Nucleic Acids Res. 2002 Jan 1;30(1):207-10 [11752295] Science. 2002 Jan 4;295(5552):127-31 [11778048] Biochem Biophys Res Commun. 2002 Feb 15;291(1):8-16 [11829454] Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2158-63 [11830642] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3264-9 [11867711] Genetics. 2002 Jun;161(2):651-60 [12072462] Bioinformatics. 2002;18 Suppl 1:S233-40 [12169552] Mol Cells. 2002 Aug 31;14(1):50-5 [12243352] Curr Biol. 2002 Sep 17;12(18):1566-73 [12372248] Oncogene. 2002 Dec 16;21(58):8949-56 [12483511] Science. 2002 Dec 20;298(5602):2398-401 [12471266] DNA Repair (Amst). 2002 Jan 22;1(1):59-75 [12509297] Nature. 2003 Jan 9;421(6919):182-7 [12483226] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The Impact Of Individual Ability, Favorable Team Member Scores, And Student Perception Of Course Importance On Student Preference Of Team-Based Learning And Grading Methods AN - 61667832; 200809818 AB - This study explores the impact of individual ability and favorable team member scores on student preference of team-based learning and grading methods, and examines the moderating effects of student perception of course importance on student preference of team-based learning and grading methods. The author also investigates the relationship between student perception of course importance and their responses to social loafing. Results indicate that individual ability on the preference of team-based learning was affected by the three levels of favorable team member scores. For students with a low level of individual ability, the preference for team-based learning was significant among students with each of three levels of favorable team member scores (p less than .05). However, the team-based learning and grading methods was not significant (p greater than .05). The findings also reveal a negative correlation between student perception of course importance and their responses to social loafing (p less than .05). Findings note the importance of teachers' grading methods, student perceptions of course importance as well as individual ability and favorable team member scores in the team selection process to promote student attitude toward team-based learning. Adapted from the source document. JF - Adolescence AU - Su, Allan Yen-Lun AD - Department of Hospitality and Recreation Management, National Pingtung University of Science and Technology, 1, Hseuh Fu Road, Nei-Pu, Pingtung 91201, Taiwan Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 805 EP - 826 PB - Libra Publishers, San Diego CA VL - 42 IS - 168 SN - 0001-8449, 0001-8449 KW - Groups KW - Grades (Scholastic) KW - Learning KW - Membership KW - Performance KW - Teaching Methods KW - article KW - 1432: sociology of education; sociology of education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61667832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Adolescence&rft.atitle=The+Impact+Of+Individual+Ability%2C+Favorable+Team+Member+Scores%2C+And+Student+Perception+Of+Course+Importance+On+Student+Preference+Of+Team-Based+Learning+And+Grading+Methods&rft.au=Su%2C+Allan+Yen-Lun&rft.aulast=Su&rft.aufirst=Allan&rft.date=2007-01-01&rft.volume=42&rft.issue=168&rft.spage=805&rft.isbn=&rft.btitle=&rft.title=Adolescence&rft.issn=00018449&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2008-04-02 N1 - Number of references - 37 N1 - Last updated - 2016-09-28 N1 - CODEN - ADOLAO N1 - SubjectsTermNotLitGenreText - Learning; Groups; Membership; Teaching Methods; Grades (Scholastic); Performance ER - TY - JOUR T1 - Identifying health disparities across the tobacco continuum AN - 61658240; 200810775 AB - Aims Few frameworks have addressed work-force diversity, inequities and inequalities as part of a comprehensive approach to eliminating tobacco-related health disparities. This paper summarizes the literature and describes the known disparities that exist along the tobacco disease continuum for minority racial and ethnic groups, those living in poverty, those with low education and blue-collar and service workers. The paper also discusses how work-force diversity, inequities in research practice and knowledge allocation and inequalities in access to and quality of health care are fundamental to addressing disparities in health. Methods We examined the available scientific literature and existing public health reports to identify disparities across the tobacco disease continuum by minority racial/ethnic group, poverty status, education level and occupation. Findings Results indicate that differences in risk indicators along the tobacco disease continuum do not explain fully tobacco-related cancer consequences among some minority racial/ethnic groups, particularly among the aggregate groups, blacks/African Americans and American Indians/Alaska Natives. The lack of within-race/ethnic group data and its interactions with socio-economic factors across the life-span contribute to the inconsistency we observe in the disease causal paradigm. Conclusions More comprehensive models are needed to understand the relationships among disparities, social context, diversity, inequalities and inequities. A systematic approach will also help researchers, practitioners, advocates and policy makers determine critical points for interventions, the types of studies and programs needed and integrative approaches needed to eliminate tobacco-related disparities. Adapted from the source document. JF - Addiction AU - Fagan, Pebbles AU - Moolchan, Eric T AU - Lawrence, Deirdre AU - Fernander, Anita AU - Ponder, Paris K AD - National Cancer Institute, Bethesda, MD, USA faganp@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 5 EP - 29 PB - Blackwell Publishing, Oxford UK VL - 102 IS - s2 SN - 0965-2140, 0965-2140 KW - Smoking KW - Black Americans KW - Minority Groups KW - Ethnic Groups KW - Health Problems KW - Social Inequality KW - Racial Differences KW - Cancer KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61658240?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Identifying+health+disparities+across+the+tobacco+continuum&rft.au=Fagan%2C+Pebbles%3BMoolchan%2C+Eric+T%3BLawrence%2C+Deirdre%3BFernander%2C+Anita%3BPonder%2C+Paris+K&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2007-01-01&rft.volume=102&rft.issue=s2&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01952.x LA - English DB - Sociological Abstracts N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-28 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Racial Differences; Ethnic Groups; Minority Groups; Black Americans; Social Inequality; Health Problems; Smoking; Cancer DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01952.x ER - TY - JOUR T1 - The Effect Of An International Embargo On Malnutrition And Childhood Mortality In Rural Haiti AN - 58767912; 2008-93109 AB - The study objective was to determine the effect of an international embargo against Haiti, from October 1991 through October 1994, on early childhood protein-energy malnutrition and all-cause mortality in a geographic area where humanitarian aid was continuously available to the children in the study. The authors used longitudinal anthropometric records on 1,593 children, 24 months old or younger, living in the rural Grand Anse Department of Haiti from 1989 through 1996. Kaplan-Meier graphs for all-cause mortality accounting for malnutrition status and stratified by calendar period were applied to the database and assessed using logrank tests. Adjusted relative risks were assessed by Cox regression. The results show that despite the continuous availability of preventive services (1989-1996), higher all-cause mortality was more strongly associated with a calendar period coinciding with the international embargo than with periods before and after the embargo. The incidence of childhood mortality and of severe malnutrition were also higher during the period of the embargo than in the periods before and after the embargo. The findings suggest that future international sanctions, even those with humanitarian/medical exceptions, could result in substantial infant death. Adapted from the source document. JF - International Journal of Health Services AU - Reid, Britt C AU - Psoter, Walter J AU - Gebrian, Bette AU - Wang, Min Qi AD - Epidemiology and Genetics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North, Room 5104, 6130 Executive Blvd., MSC 7324, Bethesda, MD 20892-7324 reidbr@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 501 EP - 513 PB - Baywood Publishing, Amityville NY VL - 37 IS - 3 SN - 0020-7314, 0020-7314 KW - Trade and trade policy - Free trade and protection KW - Health conditions and policy - Diseases and disorders KW - Health conditions and policy - Food and nutrition KW - Population groups, population policy, and demographics - Children and youth KW - Population groups, population policy, and demographics - Demography and census KW - Law and ethics - International law KW - Social conditions and policy - Rural conditions KW - Haiti KW - Infant mortality KW - Mortality KW - Embargo KW - Sanctions (international law) KW - Malnutrition KW - Humanitarian law KW - Rural conditions KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/58767912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apais&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Health+Services&rft.atitle=The+Effect+Of+An+International+Embargo+On+Malnutrition+And+Childhood+Mortality+In+Rural+Haiti&rft.au=Reid%2C+Britt+C%3BPsoter%2C+Walter+J%3BGebrian%2C+Bette%3BWang%2C+Min+Qi&rft.aulast=Reid&rft.aufirst=Britt&rft.date=2007-01-01&rft.volume=37&rft.issue=3&rft.spage=501&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Health+Services&rft.issn=00207314&rft_id=info:doi/ LA - English DB - PAIS Index N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-28 N1 - CODEN - IJHSC6 N1 - SubjectsTermNotLitGenreText - Embargo; Malnutrition; Haiti; Children; Mortality; Sanctions (international law); Humanitarian law; Rural conditions; Infant mortality ER - TY - JOUR T1 - Information needs and information seeking in a biomedical research setting: a study of scientists and science administrators. AN - 57704904; 200800657 AB - Objective: An information needs study of clinical specialists and biomedical researchers was conducted at the US National Institutes of Health (NIH) to inform library services and contribute to a broader understanding of information use in academic and research settings. Methods: A random stratified sample by job category of 500 NIH scientists was surveyed by telephone by an independent consultant using a standardized information industry instrument, augmented with locally developed questions. Results were analyzed for statistical significance using t-tests and chi square. Findings were compared with published studies and an aggregated dataset of information users in business, government, and health care from Outsell. Results: The study results highlighted similarities and differences with other studies and the industry standard, providing insights into user preferences, including new technologies. NIH scientists overwhelmingly used the NIH Library (424/500), began their searches at the library's Website rather than Google (P = < 0.001), were likely to seek information themselves (474/500), and valued desktop resources and services. Conclusion: While NIH staff work in a unique setting, they share some information characteristics with other researchers. The findings underscored the need to continue assessing specialized needs and seek innovative solutions. The study led to improvements or expansion of services such as developing a Website search engine, organizing gene sequence data, and assisting with manuscript preparation. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Grefsheim, Suzanne F AU - Rankin, Jocelyn A AD - Division of Library Services, National Institutes of Health, 10 Center Drive, MSC-1150, Bethesda, MD 20892 grefshes@nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 426 EP - 434 PB - Medical Library Association, Chicago, IL VL - 95 IS - 4 SN - 1536-5050, 1536-5050 KW - Scientists KW - User needs KW - Medicine KW - Information seeking behaviour KW - article KW - 4.14: USERS - OCCUPATIONAL GROUPS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57704904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Information+needs+and+information+seeking+in+a+biomedical+research+setting%3A+a+study+of+scientists+and+science+administrators.&rft.au=Grefsheim%2C+Suzanne+F%3BRankin%2C+Jocelyn+A&rft.aulast=Grefsheim&rft.aufirst=Suzanne&rft.date=2007-01-01&rft.volume=95&rft.issue=4&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.4.426 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Information seeking behaviour; User needs; Medicine; Scientists DO - http://dx.doi.org/10.3163/1536-5050.95.4.426 ER - TY - JOUR T1 - HIV/AIDS information outreach: a community-based approach. AN - 57704782; 200801867 AB - Objective: The paper provides an overview of the National Library of Medicine's (NLM's) AIDS Community Information Outreach Program during the years 1994 to 2005, discusses the impact of previously funded projects, and explores future implications for HIV/AIDS information outreach to communities in need. Methods: A qualitative assessment was conducted to provide information on the impact of projects funded by the AIDS Community Information Outreach Program during fiscal year 2002. Interviews were conducted and final reports were analyzed, resulting in themes based on roles and responsibilities of participants and the impact of the projects in the communities. Results: Results from the assessment suggest that access to HIV/AIDS information led to improved communication between patients and their health care providers and encouraged better health care decision making. Feedback from reports and interviews included examples of impact such as an increase in services provided to communities, national and global recognition of HIV/AIDS services, sustainability of projects, and improved communication. Conclusion: Community-based health information outreach projects may empower the HIV/AIDS community to become more involved in health care and improve communication with providers. NLM will continue to promote the AIDS Community Information Outreach Program to encourage community organizations to design local projects for their specific communities. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Dancy, Nicole C AU - Dutcher, Gale A AD - Office of Outreach and Special Populations, Division of Specialized Information Services National Library of Medicine, 6707 Democracy Boulevard, Suite 510, Bethesda, MD 20892 dancyn1@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 323 EP - 329 PB - Medical Library Association, Chicago, IL VL - 95 IS - 3 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - HIV KW - Consumer health information KW - Community information services KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57704782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=HIV%2FAIDS+information+outreach%3A+a+community-based+approach.&rft.au=Dancy%2C+Nicole+C%3BDutcher%2C+Gale+A&rft.aulast=Dancy&rft.aufirst=Nicole&rft.date=2007-01-01&rft.volume=95&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.3.323 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Community information services; Consumer health information; HIV; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.95.3.323 ER - TY - JOUR T1 - The Central American Network for Disaster and Health Information. AN - 57703276; 200800691 AB - Purpose: This paper describes an international outreach program to support rebuilding Central America's health information infrastructure after several natural disasters in the region, including Hurricane Mitch in 1998 and two major earthquakes in 2001. Setting, Participants, and Description: The National Library of Medicine joined forces with the Pan American Health Organization /World Health Organization, the United Nations International Strategy for Disaster Reduction, and the Regional Center of Disaster Information for Latin America and the Caribbean (CRID) to strengthen libraries and information centers in Central America and improve the availability of and access to health and disaster information in the region by developing the Central American Network for Disaster and Health Information (CANDHI). Through CRID, the program created ten disaster health information centers in medical libraries and disaster-related organizations in six countries. Results/Outcome: This project served as a catalyst for the modernization of several medical libraries in Central America. The resulting CANDHI provides much needed electronic access to public health 'gray literature' on disasters, as well as access to numerous health information resources. CANDHI members assist their institutions and countries in a variety of disaster preparedness activities through collecting and disseminating information. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Arnesen, Stacey J AU - Cid, Victor H AU - Scott, John C AU - Perez, Ricardo AU - Zervaas, Dave AD - National Library of Medicine, 6707 Democracy Boulevard, Suite 510, Bethesda, MD 20892 stacey_arnesen@nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 316 EP - 322 PB - Medical Library Association, Chicago, IL VL - 95 IS - 3 SN - 1536-5050, 1536-5050 KW - Disaster recovery KW - Consumer health information KW - Central America KW - Outreach services KW - article KW - 4.15: USER SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57703276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+Central+American+Network+for+Disaster+and+Health+Information.&rft.au=Arnesen%2C+Stacey+J%3BCid%2C+Victor+H%3BScott%2C+John+C%3BPerez%2C+Ricardo%3BZervaas%2C+Dave&rft.aulast=Arnesen&rft.aufirst=Stacey&rft.date=2007-01-01&rft.volume=95&rft.issue=3&rft.spage=316&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.3.316 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Outreach services; Consumer health information; Disaster recovery; Central America DO - http://dx.doi.org/10.3163/1536-5050.95.3.316 ER - TY - JOUR T1 - Enviro-health links: environmental health subject guides from the National Library of Medicine. AN - 57702285; 200802117 AB - Staff at the National Library of Medicine create Internet subject guides that direct users to reliable sites on environmental health topics and provide pre-formulated searches of the National Library of Medicine's toxicology and environmental health databases. Criteria were developed to evaluate Web sites for authority, content, intended audience, and technical reliability. Searches are created using the most appropriate subject headings and keywords and can be limited to the most recent five years or to review articles only. Thirteen subject guides have been produced covering lead, arsenic, chemical and biological warfare, environmental justice, toxicogenomics, dietary supplements, and pesticides. Future topics include mercury and hazards from art materials. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). Adapted from the source document. COPIES ARE AVAILABLE FROM: HAWORTH DOCUMENT DELIVERY CENTER, The Haworth Press, Inc., 10 Alice Street, Binghamton, NY 13904-1580 JF - Journal of Electronic Resources in Medical Libraries AU - Publicker, Stephanie AD - Specialized Information Services, National Library of Medicine, 2 Democracy Plaza, Suite 510, 6707 Democracy Blvd., MSC 5467, Bethesda, MD 20892-5467 publicks@nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1 EP - 9 PB - Haworth Press, Binghamton NY VL - 4 IS - 4 SN - 1542-4065, 1542-4065 KW - National Library of Medicine, USA KW - Environmental health KW - Searching KW - Subject indexing KW - article KW - 12.21: SUBJECT INDEXING UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57702285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.atitle=Enviro-health+links%3A+environmental+health+subject+guides+from+the+National+Library+of+Medicine.&rft.au=Publicker%2C+Stephanie&rft.aulast=Publicker&rft.aufirst=Stephanie&rft.date=2007-01-01&rft.volume=4&rft.issue=4&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Electronic+Resources+in+Medical+Libraries&rft.issn=15424065&rft_id=info:doi/10.1300%2FJ383v04n04_01 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Subject indexing; Searching; Environmental health; National Library of Medicine, USA DO - http://dx.doi.org/10.1300/J383v04n04_01 ER - TY - JOUR T1 - Use of the Internet to communicate with health care providers in the United States: estimates from the 2003 and 2005 Health Information National Trends Surveys (HINTS). AN - 57701010; 200801847 AB - Background: Despite substantial evidence that the public wants access to Internet-based communication with health care providers, online patient-provider communication remains relatively uncommon, and few studies have examined sociodemographic and health-related factors associated with the use of online communication with health care providers at a population level. Objective: The aim of the study was to use nationally representative data to report on the prevalence of and changes in use of online patient-provider communication in 2003 and 2005 and to describe sociodemographic and health-related factors associated with its use. Methods: Data for this study are from two iterations of the Health Information National Trends Survey (HINTS 2003, HINTS 2005). In both years, respondents were asked whether they had ever used email or the Internet to communicate with a doctor or a doctor's office. Adult Internet users in 2003 (n = 3982) and 2005 (n = 3244) were included in the present study. Multivariate logistic regression analysis was conducted to identify predictors for electronic communication with health care providers. Results: In 2003, 7% of Internet users had communicated online with an health care provider; this prevalence significantly increased to 10% in 2005. In multivariate analyses, Internet users with more years of education, who lived in a metro area, who reported poorer health status or who had a personal history of cancer were more likely to have used online patient-provider communication. Conclusions: Despite wide diffusion of the Internet, online patient-provider communication remains uncommon but is slowly increasing. Policy-level changes are needed to maximize the availability and effectiveness of online patient-provider communication for health care consumers and health care providers. Internet access remains a significant barrier to online patient-provider communication. Adapted from the source document. JF - Journal of Medical Internet Research AU - Burke Beckjord, Ellen AU - Finney Rutten, Lila J AU - Squiers, Linda AU - Arora, Neeraj K AU - Volckmann, Lindsey AU - Moser, Richard P AU - Hesse, Bradford W AD - National Cancer Institute, 6130 Executive Boulevard (EPN), 4051A, MSC 7365, Bethesda, MD 20892, USA beckjore@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 PB - Gunther Eysenbach MD MPH, Associate Professor, University of Toronto Senior Scientist, Centre for Global eHealth nnovation, Toronto, Canada VL - 9 IS - 3 SN - 1438-8871, 1438-8871 KW - Information communication KW - Consumer health information KW - Internet KW - Doctor-patient communication KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57701010?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Internet+Research&rft.atitle=Use+of+the+Internet+to+communicate+with+health+care+providers+in+the+United+States%3A+estimates+from+the+2003+and+2005+Health+Information+National+Trends+Surveys+%28HINTS%29.&rft.au=Burke+Beckjord%2C+Ellen%3BFinney+Rutten%2C+Lila+J%3BSquiers%2C+Linda%3BArora%2C+Neeraj+K%3BVolckmann%2C+Lindsey%3BMoser%2C+Richard+P%3BHesse%2C+Bradford+W&rft.aulast=Burke+Beckjord&rft.aufirst=Ellen&rft.date=2007-01-01&rft.volume=9&rft.issue=3&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Internet+Research&rft.issn=14388871&rft_id=info:doi/10.2196%2Fjmir.9.3.e20 L2 - http://www.jmir.org/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Doctor-patient communication; Information communication; Consumer health information; Internet DO - http://dx.doi.org/10.2196/jmir.9.3.e20 ER - TY - JOUR T1 - Addressing health disparities and environmental justice: the National Library of Medicine's Environmental Health Information Outreach Program. AN - 57699857; 200801872 AB - Purpose: Disparities in health between minority and majority populations have become a topic of high interest in the health care and information communities. This paper describes the National Library of Medicine's (NLM's) oldest outreach program to a minority population, a project that has been going on for over fifteen years. Setting/Participants/Resources: The overview is based on internal documentation and reports, interviews, personal communications, and project reports. Brief Description: This is a historical overview of the Environmental Health Information Outreach Program, from its beginnings in 1991 as the Toxicology Information Outreach Project. The initial collaboration began with nine historically black colleges and universities (HBCUs) that had graduate programs in biomedicine. The current program includes representation from HBCUs, institutions serving Hispanic students, and tribal colleges. In addition to working with these institutions to promote the use of and access to electronic health information and related technology, this program brings attention to scientific research related to health issues that disproportionately affect minorities. Results/Outcome: The program expanded due to its perceived success by the initial participants and NLM's management. Not only have faculty, staff, and students at the participating institutions received training in using NLM's toxicology, environmental health, and other electronic resources, but the participants ascribe other successes to their collaboration with NLM. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Dutcher, Gale A AU - Spann, Melvin AU - Gaines, Cynthia AD - Office of Outreach and Special Populations, Division of Specialized Information Services, National Library of Medicine, 6707 Democracy Boulevard, Suite 510, Bethesda, MD 20892 dutcherg@mail.nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 330 EP - 336 PB - Medical Library Association, Chicago, IL VL - 95 IS - 3 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - Environmental health KW - Consumer health information KW - Community information services KW - article KW - 10.14: INFORMATION SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57699857?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Addressing+health+disparities+and+environmental+justice%3A+the+National+Library+of+Medicine%27s+Environmental+Health+Information+Outreach+Program.&rft.au=Dutcher%2C+Gale+A%3BSpann%2C+Melvin%3BGaines%2C+Cynthia&rft.aulast=Dutcher&rft.aufirst=Gale&rft.date=2007-01-01&rft.volume=95&rft.issue=3&rft.spage=330&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.3.330 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Community information services; Consumer health information; Environmental health; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.95.3.330 ER - TY - JOUR T1 - The Partners in Information Access for the Public Health Workforce: a collaboration to improve and protect the public's health, 1995-2006. AN - 57699811; 200801848 AB - Objective: The paper provides a complete accounting of the Partners in Information Access for the Public Health Workforce (Partners) initiative since its inception in 1997, including antecedent activities since 1995. Methods: A descriptive overview is provided that is based on a review of meeting summaries, published reports, Websites, project reports, databases, usage statistics, and personal experiences from offices in the National Library of Medicine (NLM), six organizations that collaborate formally with NLM on the Partners initiative, and one outside funding partner. Results: With ten years of experience, the initiative is an effective and unique public-private collaboration that builds on the strengths and needs of the organizations that are involved and the constituencies that they serve. Partners-supported and sponsored projects include satellite broadcasts or Webcasts, training initiatives, Web resource development, a collection of historical literature, and strategies for workforce enumeration and expansion of public health systems research, which provide excellent examples of the benefits realized from collaboration between the public health community and health sciences libraries. Conclusions: With continued funding, existing and new Partners-sponsored projects will be able to fulfill many public health information needs. This collaboration provides excellent opportunities to strengthen the partnership between library science and public health in the use of health information and tools for purposes of improving and protecting the public's health. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Cahn, Marjorie A AU - Auston, Ione AU - Selden, Catherine R AU - Cogdill, Keith AU - Baker, Stacy AU - Cavanaugh, Debra AU - Elliott, Sterling AU - Foster, Allison J AU - Leep, Carolyn J AU - Perez, Debra Joy AU - Pomietto, Blakely R AD - National Information Center for Health Services Research and Health Care Technology, National Library of Medicine, 8600 Rockville Pike, Bethesda, MD 20894 nichsr@nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 301 EP - 309 PB - Medical Library Association, Chicago, IL VL - 95 IS - 3 SN - 1536-5050, 1536-5050 KW - Health professionals KW - Collaboration KW - Access to information KW - article KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57699811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=The+Partners+in+Information+Access+for+the+Public+Health+Workforce%3A+a+collaboration+to+improve+and+protect+the+public%27s+health%2C+1995-2006.&rft.au=Cahn%2C+Marjorie+A%3BAuston%2C+Ione%3BSelden%2C+Catherine+R%3BCogdill%2C+Keith%3BBaker%2C+Stacy%3BCavanaugh%2C+Debra%3BElliott%2C+Sterling%3BFoster%2C+Allison+J%3BLeep%2C+Carolyn+J%3BPerez%2C+Debra+Joy%3BPomietto%2C+Blakely+R&rft.aulast=Cahn&rft.aufirst=Marjorie&rft.date=2007-01-01&rft.volume=95&rft.issue=3&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.3.301 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Access to information; Collaboration; Health professionals DO - http://dx.doi.org/10.3163/1536-5050.95.3.301 ER - TY - JOUR T1 - Building better connections: the National Library of Medicine and public health. AN - 57699773; 200800718 AB - Purpose: The paper describes the expansion of the public health programs and services of the National Library of Medicine (NLM) in the 1990s and provides the context in which NLM's public health outreach programs arose and exist today. Brief Description: Although NLM has always had collections and services relevant to public health, the US public health workforce made relatively little use of the library's information services and programs in the twentieth century. In the 1990s, intensified emphases on outreach to health professionals, building national information infrastructure, and promoting health data standards provided NLM with new opportunities to reach the public health community. A seminal conference cosponsored by NLM in 1995 produced an agenda for improving public health access to and use of advanced information technology and electronic information services. NLM actively pursued this agenda by developing new services and outreach programs and promoting public health informatics initiatives. Method: Historical analysis is presented. Results /Outcome: NLM took advantage of a propitious environment to increase visibility and understanding of public health information challenges and opportunities. The library helped create partnerships that produced new information services, outreach initiatives, informatics innovations, and health data policies that benefit the public health workforce and the diverse populations it serves. Adapted from the source document. JF - Journal of the Medical Library Association (JMLA) AU - Humphreys, Betsy L AD - National Library of Medicine, National Institutes of Health, US Department of Health and Human Services, 8600 Rockville Pike, Bethesda, MD 20894 betsy.humphreys@nih.hhs.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 293 EP - 300 PB - Medical Library Association, Chicago, IL VL - 95 IS - 3 SN - 1536-5050, 1536-5050 KW - National Library of Medicine, USA KW - Environmental health KW - Outreach services KW - article KW - 4.15: USER SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57699773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.atitle=Building+better+connections%3A+the+National+Library+of+Medicine+and+public+health.&rft.au=Humphreys%2C+Betsy+L&rft.aulast=Humphreys&rft.aufirst=Betsy&rft.date=2007-01-01&rft.volume=95&rft.issue=3&rft.spage=293&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28JMLA%29&rft.issn=15365050&rft_id=info:doi/10.3163%2F1536-5050.95.3.293 L2 - http://www.mlanet.org/publications/jmla/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2008-05-15 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Outreach services; Environmental health; National Library of Medicine, USA DO - http://dx.doi.org/10.3163/1536-5050.95.3.293 ER - TY - JOUR T1 - Environmental health and toxicology resources of the United States National Library of Medicine. AN - 57697211; 00504671 AB - For over 40 years, the National Library of Medicine's (NLM) Toxicology and Environmental Health Information Program (TEHIP) has worked to organize and to provide access to an extensive array of environmental health and toxicology resources. During these years, the TEHIP program has evolved from a handful of databases developed primarily for researchers to a broad range of products and services that also serve industry, students, and the general public. TEHIP's resources include TOXNET(Registered) , a collection of databases, including online handbooks, bibliographic references, information on the release of chemicals in the environment, and a chemical dictionary. TEHIP also produces several resources aimed towards the general public, such as the Household Products Database , which helps users explore chemicals often found in common household products, and Tox Town(Registered) , an interactive guide to commonly encountered toxic substances, health, and the environment. This paper introduces some of NLM's environmental health and toxicology resources. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). (Author abstract) JF - Medical Reference Services Quarterly AU - Hochstein, Colette AU - Arnesen, Stacey AU - Goshorn, Jeanne AD - Division of Specialized Information Services (SIS), National Library of Medicine, 6707 Democracy Boulevard, Bethesda, MD 20892 colette@nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 21 EP - 45 PB - Haworth Press Inc VL - 26 IS - 3 SN - 0276-3869, 0276-3869 KW - National Library of Medicine, USA KW - Online databases KW - Environmental health KW - Medical informatics KW - Toxicology KW - 10.13: INFORMATION COMMUNICATION - SCIENCE, TECHNOLOGY, MEDICINE UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57697211?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Reference+Services+Quarterly&rft.atitle=Environmental+health+and+toxicology+resources+of+the+United+States+National+Library+of+Medicine.&rft.au=Hochstein%2C+Colette%3BArnesen%2C+Stacey%3BGoshorn%2C+Jeanne&rft.aulast=Hochstein&rft.aufirst=Colette&rft.date=2007-01-01&rft.volume=26&rft.issue=3&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Medical+Reference+Services+Quarterly&rft.issn=02763869&rft_id=info:doi/10.1300%2FJ115v26n03_02 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Medical informatics; Environmental health; Toxicology; Online databases; National Library of Medicine, USA DO - http://dx.doi.org/10.1300/J115v26n03_02 ER - TY - JOUR T1 - Empowering your institution through assessment. AN - 57687770; 00498322 AB - Objectives: The objectives of this study are to describe the process of linking Association of Academic Health Sciences Libraries (AAHSL) data with 2002 LibQUAL+ data and to address four analytical questions created by the AAHSL Task Force on Quality Assessment that relate both to user satisfaction and to services provided by AAHSL libraries. Methods: For the thirty-five AAHSL libraries that participated in the 2002 LibQUAL+ survey, nested-effect of variance was analyzed using a linear mixed model. Using the Pearson correlation coefficient, this study explored four questions about the effect of user demographics on perceived levels of satisfaction with library services. Results: The supposition that library user satisfaction may differ according to library institutional reporting structure was unsupported. Regarding effect on mean overall satisfaction, size of library staff is not significant (P = 0.860), number of constituents is slightly significant (P = 0.027), and ratio of staff to constituents has a moderate and significant effect (P = 0.004). Conclusions: From a demographic perspective, the 2002 LibQUAL+ survey represents the largest cross section of AAHSL libraries. Increased understanding of how qualitative assessment can supplement quantitative data supports evidence-based decision-making and practice. It also could promote changes in data collection and usage. (Author abstract) JF - Journal of the Medical Library Association ( JMLA ) AU - Joubert, Douglas J AU - Lee, Tamera P AD - National Institutes of Health, Library Bldg. 10 Room 1L09A, Bethesda, MD 20906-1150 joubertd@ors.od.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 46 EP - 53 PB - Medical Library Association VL - 95 IS - 1 SN - 1536-5050, 1536-5050 KW - Assessment KW - User services KW - Association of Academic Health Sciences Libraries KW - Service quality KW - Medical libraries KW - User satisfaction KW - 4.15: USER SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57687770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=Empowering+your+institution+through+assessment.&rft.au=Joubert%2C+Douglas+J%3BLee%2C+Tamera+P&rft.aulast=Joubert&rft.aufirst=Douglas&rft.date=2007-01-01&rft.volume=95&rft.issue=1&rft.spage=46&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-10-29 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - User services; User satisfaction; Medical libraries; Assessment; Service quality; Association of Academic Health Sciences Libraries ER - TY - JOUR T1 - DOCLINE(Registered): an overview of the DOCLINE system, its functions, purposes and descriptions of participating libraries. AN - 57664834; 00505035 AB - In March 2006, NLM released DOCLINE version 2.7 adding several major enhancements to the National Library of Medicine's interlibrary loan request routing and referral system. This paper presents an overview of the DOCLINE system, its functions, purposes, and descriptions of participating libraries. A summary of interlibrary loan statistics is also included. DOCLINE 2.7 provides new functionality to accommodate the growing shift to delivery of articles via electronic means. It also adds new features to request routing to provide a wider pool of potential lenders so that borrowers have access to the full resources of DOCLINE libraries. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). (Author abstract) JF - Journal of Interlibrary Loan, Document Supply and Electronic Reserve AU - Collins, Maria Elizabeth AD - DOCLINE Product Lead, National Library of Medicine, Public Services Division/Collection Access Section, 8600 Rockville Pike, Bethesda, MD 20894 maria_collins@nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 15 EP - 28 PB - Haworth Press Inc VL - 17 IS - 3 SN - 1072-303X, 1072-303X KW - Software KW - National Library of Medicine, USA KW - DOCLINE KW - Medical libraries KW - Online document delivery KW - Interloans KW - 4.21: INTERLOANS AND PHOTOCOPYING SERVICES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57664834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interlibrary+Loan%2C+Document+Supply+and+Electronic+Reserve&rft.atitle=DOCLINE%28Registered%29%3A+an+overview+of+the+DOCLINE+system%2C+its+functions%2C+purposes+and+descriptions+of+participating+libraries.&rft.au=Collins%2C+Maria+Elizabeth&rft.aulast=Collins&rft.aufirst=Maria&rft.date=2007-01-01&rft.volume=17&rft.issue=3&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interlibrary+Loan%2C+Document+Supply+and+Electronic+Reserve&rft.issn=1072303X&rft_id=info:doi/10.1300%2FJ474v17n03_05 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Interloans; Online document delivery; Software; Medical libraries; DOCLINE; National Library of Medicine, USA DO - http://dx.doi.org/10.1300/J474v17n03_05 ER - TY - JOUR T1 - The PubMed Central Archive and the back issue scanning project. AN - 57648225; 00505044 AB - This paper is a description of the National Library of Medicine's PubMed Central. PubMed Central comprises back issue scanning and digitization project of scanned back issues journals from the mid 1800s and current content from publishers. The National Library of Medicine's PubMed Central Archive is growing by thousands of articles per month. The back issues now account for two-thirds of the total archive of about 720,000 articles from 210 journals. (Copies of this article are available for a fee from the Haworth Document Delivery Service, Haworth Press, Inc. E-Mail: getinfo@haworthpressinc.com, Web site http://www.HaworthPress.com). (Author abstract) JF - Journal of Interlibrary Loan, Document Supply and Electronic Reserve AU - Fishel, Martha AU - Myers, Carol J AD - National Library of Medicine, 8066 Rockville Pike, Bethesda, MD 20894 martha.fishel@nlm.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 109 EP - 116 PB - Haworth Press Inc VL - 17 IS - 3 SN - 1072-303X, 1072-303X KW - Open access KW - National Library of Medicine, USA KW - PubMed Central KW - Electronic publishing KW - Digital archives KW - 3.2: ARCHIVES UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57648225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Interlibrary+Loan%2C+Document+Supply+and+Electronic+Reserve&rft.atitle=The+PubMed+Central+Archive+and+the+back+issue+scanning+project.&rft.au=Fishel%2C+Martha%3BMyers%2C+Carol+J&rft.aulast=Fishel&rft.aufirst=Martha&rft.date=2007-01-01&rft.volume=17&rft.issue=3&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Journal+of+Interlibrary+Loan%2C+Document+Supply+and+Electronic+Reserve&rft.issn=1072303X&rft_id=info:doi/10.1300%2FJ474v17n03_14 LA - English DB - Library & Information Science Abstracts (LISA) N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Digital archives; Electronic publishing; Open access; PubMed Central; National Library of Medicine, USA DO - http://dx.doi.org/10.1300/J474v17n03_14 ER - TY - JOUR T1 - Adolescents with Conduct Disorder: Early Smoking and Treatment Requests AN - 57288156; 200913658 AB - This study explored the relationship of a diagnosis of conduct disorder (CD) with the developmental smoking trajectory among 117 adolescent volunteers. Logistic regression analyses revealed that adolescents with CD smoked their first whole cigarette earlier (p = 0.03) and sought cessation treatment earlier (p = .01) compared to non-CD adolescents. Additionally, adolescents who smoked their first whole cigarette before the age of nine were eight times more likely to have CD. These findings suggest that in addition to addressing disruptive behaviors, early prevention and access to interventions for tobacco use are needed for youths with CD. Adapted from the source document. JF - The American Journal on Addictions AU - Bagot, Kara S AU - Berarducci, Jennifer M AU - Franken, Frederick H AU - Frazier, Matthew J AU - Ernst, Monique AU - Moolchan, Eric T AD - The National Institute on Drug Abuse, Intramural Research Program, Baltimore, Maryland Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 62 EP - 66 PB - Informa Healthcare, Taylor & Francis, New York NY VL - 16 IS - 1 SN - 1055-0496, 1055-0496 KW - Smoking KW - Initiation KW - Cessation KW - Conduct disordered adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57288156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+on+Addictions&rft.atitle=Adolescents+with+Conduct+Disorder%3A+Early+Smoking+and+Treatment+Requests&rft.au=Bagot%2C+Kara+S%3BBerarducci%2C+Jennifer+M%3BFranken%2C+Frederick+H%3BFrazier%2C+Matthew+J%3BErnst%2C+Monique%3BMoolchan%2C+Eric+T&rft.aulast=Bagot&rft.aufirst=Kara&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=62&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+on+Addictions&rft.issn=10550496&rft_id=info:doi/10.1080%2F10550490601080100 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-07-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Smoking; Cessation; Conduct disordered adolescents; Initiation DO - http://dx.doi.org/10.1080/10550490601080100 ER - TY - JOUR T1 - Infant childcare settings and the development of gender-specific adaptive behaviors AN - 57253684; 200815817 AB - In this study, we defined three distinct groups based on the infant's principal childcare experience: infants reared exclusively at home by their mothers, infants reared in their own homes but by a non-familial childcare provider, and infants reared in non-familial homes in group care. At 4.5 years of age, we compared mothers' and teachers' independent views of the communication, daily living, socialization and motor adaptive behaviors of girls and boys with these different infant childcare histories, after taking multiple family selection factors into consideration. Boys who had other-home-group-care in infancy expressed lower levels of overall adaptive functioning, as well as communication, daily living and socialization skills, than girls. Girls with other-home-group-care in infancy had better adaptive daily living and socialization skills than girls who had maternal care. Different infant childcare experiences appear to predict different adaptive behaviors in boys and girls. Adapted from the source document. JF - Early Child Development and Care AU - Bornstein, Marc H AU - Hahn, Chun-Shin AD - National Institute of Child Health and Human Development, Maryland, USA Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 15 EP - 41 PB - Routledge/Taylor & Francis, UK VL - 177 IS - 1 SN - 0300-4430, 0300-4430 KW - Day care centres KW - Mother-Infant interactions KW - Gender differences KW - Child development KW - Child care KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57253684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Early+Child+Development+and+Care&rft.atitle=Infant+childcare+settings+and+the+development+of+gender-specific+adaptive+behaviors&rft.au=Bornstein%2C+Marc+H%3BHahn%2C+Chun-Shin&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2007-01-01&rft.volume=177&rft.issue=1&rft.spage=15&rft.isbn=&rft.btitle=&rft.title=Early+Child+Development+and+Care&rft.issn=03004430&rft_id=info:doi/10.1080%2F03004430500317192 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Gender differences; Child care; Mother-Infant interactions; Day care centres; Child development DO - http://dx.doi.org/10.1080/03004430500317192 ER - TY - JOUR T1 - Russian Alcohol Policy In The Making AN - 57250595; 200816261 AB - Aims: This paper examines implementation of the 2005 federal alcohol control law in the Russian Federation. Methods: The documents on the Russian Federation federal legislation on the control of the production and turnover of ethyl alcohol, and ethyl alcohol containing products, news reports, research, and historical documents were gathered and analysed for implementation barriers. Results: Consumption of alcoholic beverages, especially spirits, has been one the most significant public health problems in Russia for many centuries. Prior attempts to control alcohol consumption have been unsuccessful, in part due to the government's reliance on alcohol revenue, and its inability to implement creative and manageable solutions in the light of the high drinking rates. Implementation of this legislation has been a challenge in Russia because of administrative oversight, lack of organizational preparation, and corruption. Conclusions: The law discussed in this paper presented a window of opportunity to ameliorate the deteriorating health status and reverse the impending mortality crisis. However, a number of barriers presented substantial setbacks toward realization of this legislation. Adapted from the source document. JF - Alcohol and Alcoholism AU - Levintova, Marya AD - Fogarty International Center National Institutes of Health 31 Center Drive, Room B2C11 Bethesda, MD 20892 levintovam@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 500 EP - 505 PB - Oxford University Press, UK VL - 42 IS - 5 SN - 0735-0414, 0735-0414 KW - Alcohol consumption KW - Health policy KW - Russian Federation KW - Legislation KW - Public health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57250595?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcohol+and+Alcoholism&rft.atitle=Russian+Alcohol+Policy+In+The+Making&rft.au=Levintova%2C+Marya&rft.aulast=Levintova&rft.aufirst=Marya&rft.date=2007-01-01&rft.volume=42&rft.issue=5&rft.spage=500&rft.isbn=&rft.btitle=&rft.title=Alcohol+and+Alcoholism&rft.issn=07350414&rft_id=info:doi/10.1093%2Falcalc%2Fagm040 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-08-04 N1 - Last updated - 2016-09-27 N1 - CODEN - ALALDD N1 - SubjectsTermNotLitGenreText - Public health; Russian Federation; Alcohol consumption; Health policy; Legislation DO - http://dx.doi.org/10.1093/alcalc/agm040 ER - TY - JOUR T1 - Does cannabis use predict the first incidence of mood and anxiety disorders in the adult population? AN - 57239975; 200808650 AB - Aims To investigate whether cannabis use predicted the first incidence of mood and anxiety disorders in adults during a 3-year follow-up period. Design and participants Data were derived from the Netherlands Mental Health Survey and Incidence Study (NEMESIS), a prospective study in the adult population of 18-64years. The analysis was carried out on 3881 people who had no life-time mood disorders and on 3854 people who had no life-time anxiety disorders at baseline. Measurements Life-time cannabis use and DSM-III-R mood and anxiety disorders, assessed with the Composite International Diagnostic Interview (CIDI). Findings After adjustment for strong confounders, any use of cannabis at baseline predicted a modest increase in the risk of a first major depression (odds ratio 1.62; 95% confidence interval 1.06-2.48) and a stronger increase in the risk of a first bipolar disorder (odds ratio 4.98; 95% confidence interval 1.80-13.81). The risk of 'any mood disorder' was elevated for weekly and almost daily users but not for less frequent use patterns. However, dose-response relationships were less clear for major depression and bipolar disorder separately. None of the associations between cannabis use and anxiety disorders remained significant after adjustment for confounders. Conclusions The associations between cannabis use and the first incidence of depression and bipolar disorder, which remained significant after adjustment for strong confounders, warrant research into the underlying mechanisms. Adapted from the source document. JF - Addiction AU - van Laar, Margriet AU - van Dorsselaer, Saskia AU - Monshouwer, Karin AU - de Graaf, Ron AD - Trimbos Institute, Netherlands National Institute of Mental Health and Addiction, Utrecht, the Netherlands Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1251 EP - 1260 PB - Blackwell Publishing, Oxford UK VL - 102 IS - 8 SN - 0965-2140, 0965-2140 KW - Users KW - Depression KW - Anxiety disorders KW - Predictors KW - Affective disorders KW - Cannabis KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57239975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Does+cannabis+use+predict+the+first+incidence+of+mood+and+anxiety+disorders+in+the+adult+population%3F&rft.au=van+Laar%2C+Margriet%3Bvan+Dorsselaer%2C+Saskia%3BMonshouwer%2C+Karin%3Bde+Graaf%2C+Ron&rft.aulast=van+Laar&rft.aufirst=Margriet&rft.date=2007-01-01&rft.volume=102&rft.issue=8&rft.spage=1251&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01875.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Predictors; Users; Cannabis; Anxiety disorders; Affective disorders; Depression DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01875.x ER - TY - JOUR T1 - Young Children's References to Temporal Attributes of Allegedly Experienced Events in the Course of Forensic Interviews AN - 57237694; 200807811 AB - Developmental differences in references to temporal attributes of allegedly experienced events were examined in 250 forensic interviews of 4- to 10-year-old alleged victims of sexual abuse. Children's ages, the specific temporal attributes referenced, and the types of memory tapped by the interviewers' questions significantly affected the quantity and quality of temporal references produced. The findings documented age-related increases in 4- to 10-year-olds' references to temporal attributes, using the appropriate relational terminology, both spontaneously and in response to temporal requests. More references to temporal attributes were elicited from recall than from recognition memory, highlighting spontaneous reporting capabilities. Implications for theories concerning the developing understanding of temporal concepts and for the design of effective, age-appropriate, forensic interview techniques are discussed. Adapted from the source document. JF - Child Development AU - Orbach, Yael AU - Lamb, Michael E AD - National Institute of Child Health and Human Development Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1100 EP - 1120 PB - Blackwell Publishers, Malden MA VL - 78 IS - 4 SN - 0009-3920, 0009-3920 KW - Quantity KW - Young children KW - Terminology KW - Interviewers KW - Capabilities KW - Recognition memory KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57237694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Child+Development&rft.atitle=Young+Children%27s+References+to+Temporal+Attributes+of+Allegedly+Experienced+Events+in+the+Course+of+Forensic+Interviews&rft.au=Orbach%2C+Yael%3BLamb%2C+Michael+E&rft.aulast=Orbach&rft.aufirst=Yael&rft.date=2007-01-01&rft.volume=78&rft.issue=4&rft.spage=1100&rft.isbn=&rft.btitle=&rft.title=Child+Development&rft.issn=00093920&rft_id=info:doi/10.1111%2Fj.1467-8624.2007.01055.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - CHDEAW N1 - SubjectsTermNotLitGenreText - Quantity; Terminology; Interviewers; Young children; Recognition memory; Capabilities DO - http://dx.doi.org/10.1111/j.1467-8624.2007.01055.x ER - TY - JOUR T1 - Research Review: A neuroscience framework for pediatric anxiety disorders AN - 57233310; 200807907 AB - Across a range of mammalian species, early developmental variations in fear-related behaviors constrain patterns of anxious behavior throughout life. Individual differences in anxiety among rodents and non-human primates have been shown to reflect early-life influences of genes and the environment on brain circuitry. However, in humans, the manner in which genes and the environment developmentally shape individual differences in anxiety and associated brain circuitry remains poorly specified. The current review presents a conceptual framework that facilitates clinical research examining developmental influences on brain circuitry and anxiety. Research using threat-exposure paradigms might most directly integrate basic and clinical perspectives on pediatric anxiety. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Pine, Daniel S AD - Section on Development and Affective Neuroscience, National Institute of Mental Health Intramural Research Program, Bethesda, MD, USA daniel.pine@nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 631 EP - 648 PB - Blackwell Publishing, Oxford UK VL - 48 IS - 7 SN - 0021-9630, 0021-9630 KW - Paediatrics KW - Individual differences KW - Anxiety disorders KW - Genes KW - Neurosciences KW - Brain KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57233310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Research+Review%3A+A+neuroscience+framework+for+pediatric+anxiety+disorders&rft.au=Pine%2C+Daniel+S&rft.aulast=Pine&rft.aufirst=Daniel&rft.date=2007-01-01&rft.volume=48&rft.issue=7&rft.spage=631&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2007.01751.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Brain; Paediatrics; Genes; Individual differences; Anxiety disorders; Neurosciences DO - http://dx.doi.org/10.1111/j.1469-7610.2007.01751.x ER - TY - JOUR T1 - Nurse Migration from a Source Country Perspective: Philippine Country Case Study AN - 57232511; 200807394 AB - Objectives: To describe nurse migration patterns in the Philippines and their benefits and costs. Principal Findings: The Philippines is a job-scarce environment and, even for those with jobs in the health care sector, poor working conditions often motivate nurses to seek employment overseas. The country has also become dependent on labor migration to ease the tight domestic labor market. National opinion has generally focused on the improved quality of life for individual migrants and their families, and on the benefits of remittances to the nation. However, a shortage of highly skilled nurses and the massive retraining of physicians to become nurses elsewhere has created severe problems for the Filipino health system, including the closure of many hospitals. As a result, policy makers are debating the need for new policies to manage migration such that benefits are also returned to the educational institutions and hospitals that are producing the emigrant nurses. Conclusions and Recommendations: There is new interest in the Philippines in identifying ways to mitigate the costs to the health system of nurse emigration. Many of the policy options being debated involve collaboration with those countries recruiting Filipino nurses. Bilateral agreements are essential for managing migration in such a way that both sending and receiving countries derive benefit from the exchange. Adapted from the source document. JF - Health Services Research AU - Lorenzo, Fely Marilyn E AU - Galvez-Tan, Jaime AU - Icamina, Kriselle AU - Javier, Lara AD - Institute of Health Policy and Development Studies, National Institutes of Health, University of the Philippines, Manila, 625 Pedro Gil St., 1000 Ermita, Manila, Philippines Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1406 EP - 1418 PB - Blackwell Publishers, Oxford UK VL - 42 IS - 3p2 SN - 0017-9124, 0017-9124 KW - Philippines KW - Labour market KW - Nurses KW - Retraining KW - Migration KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57232511?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Services+Research&rft.atitle=Nurse+Migration+from+a+Source+Country+Perspective%3A+Philippine+Country+Case+Study&rft.au=Lorenzo%2C+Fely+Marilyn+E%3BGalvez-Tan%2C+Jaime%3BIcamina%2C+Kriselle%3BJavier%2C+Lara&rft.aulast=Lorenzo&rft.aufirst=Fely+Marilyn&rft.date=2007-01-01&rft.volume=42&rft.issue=3p2&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Health+Services+Research&rft.issn=00179124&rft_id=info:doi/10.1111%2Fj.1475-6773.2007.00716.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - HESEA5 N1 - SubjectsTermNotLitGenreText - Nurses; Migration; Philippines; Retraining; Labour market DO - http://dx.doi.org/10.1111/j.1475-6773.2007.00716.x ER - TY - JOUR T1 - Incentive-related modulation of cognitive control in healthy, anxious, and depressed adolescents: development and psychopathology related differences AN - 57230962; 200806772 AB - Background: Developmental changes in cognitive and affective processes contribute to adolescent risk-taking behavior, emotional intensification, and psychopathology. The current study examined adolescent development of cognitive control processes and their modulation by incentive, in health and psychopathology. Predictions include 1) better cognitive control in adults than adolescents, and in healthy adolescents than anxious and depressed adolescents, and 2) a stronger influence of incentives in adolescents than adults, and in healthy adolescents than their depressed and anxious counterparts. Methods: Antisaccadic eye movement parameters, which provide a measure of cognitive control, were collected during a reward antisaccade task that included parameterized incentive levels. Participants were 20 healthy adults, 30 healthy adolescents, 16 adolescents with an anxiety disorder, and 11 adolescents with major depression. Performance accuracy and saccade latency were analyzed to test both developmental and psychopathology hypotheses. Results: Development and psychopathology group differences in cognitive control were found. Specifically, adults performed better than healthy adolescents, and healthy adolescents than anxious and depressed adolescents. Incentive improved accuracy for all groups; however, incremental increases were not sufficiently large to further modulate performance. Incentives also affected saccade latencies, pushing healthy adolescent latencies to adult levels, while being less effective in adolescents with depression or anxiety. This latter effect was partially mediated by anxiety symptom severity. Conclusions: Current findings evidence the modulation of cognitive control processes by incentives. While seen in both healthy adults and healthy adolescents, this modulatory effect was stronger in youth. While anxious and depressed adolescents exhibited improved cognitive control under incentives, this effect was smaller than that in healthy adolescents. These findings suggest differential incentive and/or cognitive control processing in anxiety and depression, and across development. Differences could result from disorder specific, or combined developmental and pathological mechanisms. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Hardin, Michael G AU - Schroth, Elizabeth AU - Pine, Daniel S AU - Ernst, Monique AD - Emotional Development and Affective Neuroscience Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH /DHHS, USA hardinm@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 446 EP - 454 PB - Blackwell Publishing, Oxford UK VL - 48 IS - 5 SN - 0021-9630, 0021-9630 KW - Depression KW - Anxiety KW - Executive control KW - Psychopathology KW - Incentives KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57230962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Incentive-related+modulation+of+cognitive+control+in+healthy%2C+anxious%2C+and+depressed+adolescents%3A+development+and+psychopathology+related+differences&rft.au=Hardin%2C+Michael+G%3BSchroth%2C+Elizabeth%3BPine%2C+Daniel+S%3BErnst%2C+Monique&rft.aulast=Hardin&rft.aufirst=Michael&rft.date=2007-01-01&rft.volume=48&rft.issue=5&rft.spage=446&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2006.01722.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Executive control; Incentives; Adolescents; Anxiety; Psychopathology; Depression DO - http://dx.doi.org/10.1111/j.1469-7610.2006.01722.x ER - TY - JOUR T1 - Enhancing employee capacity to prioritize health insurance benefits AN - 57230026; 200809953 AB - Objective: To demonstrate that employees can gain understanding of the financial constraints involved in designing health insurance benefits. Background: While employees who receive their health insurance through the workplace have much at stake as the cost of health insurance rises, they are not necessarily prepared to constructively participate in prioritizing their health insurance benefits in order to limit cost. Design: Structured group exercises. Setting and participants: Employees of 41 public and private organizations in Northern California. Intervention: Administration of the CHAT (Choosing Healthplans All Together) exercise in which participants engage in deliberation to design health insurance benefits under financial constraints. Main outcome measures: Change in priorities and attitudes about the need to exercise insurance cost constraints. Results: Participants ( N =744) became significantly more cognizant of the need to limit insurance benefits for the sake of affordability and capable of prioritizing benefit options. Those agreeing that it is reasonable to limit health insurance coverage given the cost increased from 47% to 72%. Conclusion: It is both possible and valuable to involve employees in priority setting regarding health insurance benefits through the use of structured decision tools. Adapted from the source document. JF - Health Expectations AU - Danis, Marion AU - Goold, Susan Dorr AU - Parise, Carol AU - Ginsburg, Marjorie AD - Head, Section on Ethics and Health Policy, National Institutes of Health, Bethesda, MD, USA mdanis@nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 236 EP - 247 PB - Blackwell Publishing, Oxford UK VL - 10 IS - 3 SN - 1369-6513, 1369-6513 KW - Affordability KW - Prioritizing KW - Priorities KW - Health insurance KW - Exercise KW - Workplaces KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57230026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Enhancing+employee+capacity+to+prioritize+health+insurance+benefits&rft.au=Danis%2C+Marion%3BGoold%2C+Susan+Dorr%3BParise%2C+Carol%3BGinsburg%2C+Marjorie&rft.aulast=Danis&rft.aufirst=Marion&rft.date=2007-01-01&rft.volume=10&rft.issue=3&rft.spage=236&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2007.00442.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - HEHPFM N1 - SubjectsTermNotLitGenreText - Health insurance; Exercise; Prioritizing; Priorities; Affordability; Workplaces DO - http://dx.doi.org/10.1111/j.1369-7625.2007.00442.x ER - TY - JOUR T1 - Perceived ambiguity about cancer prevention recommendations: associations with cancer-related perceptions and behaviours in a US population survey AN - 57228979; 200809989 AB - Background: Health information reaching the public today is often characterized by what decision theorists have termed 'ambiguity'- i.e. uncertainty regarding the information's reliability, credibility or adequacy. This is a critical problem, as growing research suggests that ambiguity has important effects-promoting pessimistic judgments about risks and potential outcomes of risk-reducing behaviours, and lowering adoption of these behaviours. However, little is known about the public's perceptions of ambiguity in the health information domain, the effects of these perceptions, and the factors that influence these effects. Objective: To examine associations between perceived ambiguity regarding cancer prevention recommendations and prevention-related perceptions and behaviours, and to explore how these associations differ by cancer type. Study design and participants: Cross-sectional analysis of data on 4070 adults participating in the 2005 US Health Information National Trends Survey. Main variables and outcome measuresWe examined associations between perceived ambiguity about colon, skin and lung cancer prevention recommendations and two main outcome variables: (i) risk-related cognitions (perceived cancer risk and preventability, cancer-related worry) and (ii) risk-modifying behaviours (colon cancer screening, sunscreen use and smoking abstinence). Results: Perceived ambiguity was inversely associated with perceptions of the preventability of all three cancers, and with cancer-specific risk-modifying behaviours including sigmoidoscopy-colonoscopy testing, sunscreen use and smoking abstinence. Relationships with cancer risk perceptions and worry varied across different cancer types. Conclusions: Perceived ambiguity about cancer prevention recommendations has significant and predictable associations with cancer prevention-related cognitions and behaviours, and some associations differ by cancer type. These findings have implications for future research and communication efforts. Adapted from the source document. JF - Health Expectations AU - Han, Paul K J AU - Moser, Richard P AU - Klein, William M P AD - Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA hanp@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 321 EP - 336 PB - Blackwell Publishing, Oxford UK VL - 10 IS - 4 SN - 1369-6513, 1369-6513 KW - Perceptions KW - Prevention KW - Risk behaviour KW - Behaviour KW - Ambiguity KW - Cancer KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57228979?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Expectations&rft.atitle=Perceived+ambiguity+about+cancer+prevention+recommendations%3A+associations+with+cancer-related+perceptions+and+behaviours+in+a+US+population+survey&rft.au=Han%2C+Paul+K+J%3BMoser%2C+Richard+P%3BKlein%2C+William+M+P&rft.aulast=Han&rft.aufirst=Paul+K&rft.date=2007-01-01&rft.volume=10&rft.issue=4&rft.spage=321&rft.isbn=&rft.btitle=&rft.title=Health+Expectations&rft.issn=13696513&rft_id=info:doi/10.1111%2Fj.1369-7625.2007.00456.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - CODEN - HEHPFM N1 - SubjectsTermNotLitGenreText - Cancer; Ambiguity; Prevention; Perceptions; Behaviour; Risk behaviour DO - http://dx.doi.org/10.1111/j.1369-7625.2007.00456.x ER - TY - JOUR T1 - Self-administration of drugs in animals and humans as a model and an investigative tool AN - 57227893; 200807841 AB - Aim To review briefly the methods, assumptions, models, accomplishments, drawbacks and future directions of research using drug self-administration in animals and humans. Background The use of drug self-administration to study addiction is based on the assumption that drugs reinforce the behavior that results in their delivery. A wide range of drug self-administration techniques have been developed to model specific aspects of addiction. These techniques are highly amenable to being combined with a wide variety of neuroscience techniques. Conclusions The identification of drug use as behavior that is reinforced by drugs has contributed greatly to the understanding and treatment of addiction. As part of a program of pre-clinical research that also involves screening with a variety of simpler behavioral techniques, drug self-administration procedures can provide an important last step in testing potential treatments for addiction. There is currently a concerted effort to develop self-administration procedures that model the extreme nature of the behavior engendered by addiction. As advances continue to be made in neuroscience techniques, self-administration should continue to provide a means of applying these techniques within a sophisticated and valid model of human drug addiction. Adapted from the source document. JF - Addiction AU - Panlilio, Leigh V AU - Goldberg, Steven R AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, USA Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1863 EP - 1870 PB - Blackwell Publishing, Oxford UK VL - 102 IS - 12 SN - 0965-2140, 0965-2140 KW - Animals KW - Neurosciences KW - Drug addiction KW - Selfmedication KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Self-administration+of+drugs+in+animals+and+humans+as+a+model+and+an+investigative+tool&rft.au=Panlilio%2C+Leigh+V%3BGoldberg%2C+Steven+R&rft.aulast=Panlilio&rft.aufirst=Leigh&rft.date=2007-01-01&rft.volume=102&rft.issue=12&rft.spage=1863&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02011.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Selfmedication; Drug addiction; Animals; Neurosciences DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02011.x ER - TY - JOUR T1 - The Alcohol Dependence Syndrome, 30years later: a commentary AN - 57227646; 200807349 AB - Aims Major classification systems for alcohol use disorders (DSM-IV and ICD-10) contain elements of the 1976 Edwards and Gross formulation of the Alcohol Dependence Syndrome (ADS). However, issues remain about the criteria that identify Alcohol Dependence (AD) as distinct from Alcohol Abuse (AA) in DSM-IV and Harmful Use in ICD-10. These issues, in part, have their roots in changing historical perceptions of alcohol use and its problems. We discuss current diagnostic criteria for AA and AD, collectively called Alcohol Use Disorders (AUDs), in the context of their historical evolution; research progress in understanding alcohol problems, including alcohol dependence; new findings on the severity of AUDs as classified by DSM-IV; and the role of alcohol consumption patterns in future classifications of AUDs. Methods This paper is based largely on the 2006 H. David Archibald Lecture. Parts of the original lecture have been modified to reflect more recent findings from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) of the US National Institute on Alcohol Abuse and Alcoholism (NIAAA). Results The original Edwards and Gross ADS construct is supported by advances in biological and behavioral science over the past 30years. New findings indicate that DSM-IV AA and AD are not diagnostically distinct entities, but represent a continuum of severity of AUDs. The ADS criteria may best represent one quantifiable dimension of alcohol use problems and this scale can be related to that of the frequency of harmful patterns of drinking. Conclusion The Edwards and Gross ADS criteria can be used as the basis for beginning the development of scalable multi-dimensional criteria for diagnosing AUDs in new initiatives to revise DSM-IV and ICD-10. Adapted from the source document. JF - Addiction AU - Li, Ting-Kai AU - Hewitt, Brenda G AU - Grant, Bridget F AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD, USA Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1522 EP - 1530 PB - Blackwell Publishing, Oxford UK VL - 102 IS - 10 SN - 0965-2140, 0965-2140 KW - Diagnostic and Statistical Manual IV KW - Classification KW - Alcohol related problems KW - Alcohol abuse KW - Alcohol dependence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227646?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=The+Alcohol+Dependence+Syndrome%2C+30years+later%3A+a+commentary&rft.au=Li%2C+Ting-Kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-01-01&rft.volume=102&rft.issue=10&rft.spage=1522&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01911.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Alcohol abuse; Alcohol dependence; Alcohol related problems; Classification; Diagnostic and Statistical Manual IV DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01911.x ER - TY - JOUR T1 - Addressing tobacco-related health disparities AN - 57227578; 200807662 AB - Aims The aim of this review is to outline a transdisciplinary research framework for identifying, explaining and intervening to address tobacco-related health disparities (TRHD). We will show the importance of an approach that integrates the human life-cycle (developmental) and tobacco addiction cycle (behavioral) for interventions that address group-specific vulnerabilities. Methods The existing empirical knowledge base on tobacco-related health disparities is mapped onto a conceptual framework built around life-cycle and addiction cycle trajectories for disparate population groups. Findings Current knowledge about developmental trajectories of tobacco use is based on general population studies with minimal information on group differences. At the national level, early onset of tobacco use is associated with a high level of tobacco dependence, low number of quit attempts, long-term smoking history and tobacco-related health harm. These relationships cannot be assumed for all population groups: African Americans and Asian Americans typically have a later age of tobacco use onset compared to European Americans, yet health consequences of smoking are higher among African Americans but not Asian Americans. Even less is known about group differences in the temporal progression from smoking onset to daily smoking. Determining the time-frame from initial to regular smoking seems crucial for targeted secondary prevention, before the establishment of addictive tobacco use patterns. Group-specific data characterizing the duration from daily tobacco use to a quit attempt or request for cessation treatment are also scant. Conclusions A comprehensive, integrated, transdisciplinary framework is needed to guide efforts to understand tobacco-related health disparities and to increase the effectiveness of evidence-based interventions delivered in culturally appropriate and economically practicable ways, while optimizing the balance between demand for and access to services. Adapted from the source document. JF - Addiction AU - Moolchan, Eric T AU - Fagan, Pebbles AU - Fernander, Anita F AU - Velicer, Wayne F AU - Hayward, Mark D AU - King, Gary AU - Clayton, Richard R AD - National Institute on Drug Abuse, Baltimore, MD Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 30 EP - 42 PB - Blackwell Publishing, Oxford UK VL - 102 IS - s2 SN - 0965-2140, 0965-2140 KW - Smoking KW - Health problems KW - Black American people KW - Health inequalities KW - Tobacco KW - Asian American people KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Addressing+tobacco-related+health+disparities&rft.au=Moolchan%2C+Eric+T%3BFagan%2C+Pebbles%3BFernander%2C+Anita+F%3BVelicer%2C+Wayne+F%3BHayward%2C+Mark+D%3BKing%2C+Gary%3BClayton%2C+Richard+R&rft.aulast=Moolchan&rft.aufirst=Eric&rft.date=2007-01-01&rft.volume=102&rft.issue=s2&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.01953.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Tobacco; Smoking; Health inequalities; Black American people; Asian American people; Health problems DO - http://dx.doi.org/10.1111/j.1360-0443.2007.01953.x ER - TY - JOUR T1 - THE ALCOHOL DEPENDENCE SYNDROME, 30YEARS LATER-A RESPONSE TO THE COMMENTARIES AN - 57227557; 200807348 AB - Abstract not provided by publisher. JF - Addiction AU - Li, Ting-Kai AU - Hewitt, Brenda G AU - Grant, Bridget F AD - National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-9304, USA. : Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1537 EP - 1538 PB - Blackwell Publishing, Oxford UK VL - 102 IS - 10 SN - 0965-2140, 0965-2140 KW - Alcohol dependence KW - Alcohol related disorders KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57227557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=THE+ALCOHOL+DEPENDENCE+SYNDROME%2C+30YEARS+LATER-A+RESPONSE+TO+THE+COMMENTARIES&rft.au=Li%2C+Ting-Kai%3BHewitt%2C+Brenda+G%3BGrant%2C+Bridget+F&rft.aulast=Li&rft.aufirst=Ting-Kai&rft.date=2007-01-01&rft.volume=102&rft.issue=10&rft.spage=1537&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02005.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Alcohol related disorders; Alcohol dependence DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02005.x ER - TY - JOUR T1 - A new perspective on the effects of price promotions in Taiwan: a longitudinal study of a Chinese society AN - 57226387; 200809967 AB - This study investigated the effects of price promotions on consumers' brand affect. Given the inconsistent findings in previous research, it is proposed that the effects of price promotion depend on two moderator variables: brand image and consumer loyalty. For high loyalty consumers of a prestigious brand, price incentive incompatible with the brand image can hurt the brand affect. When a non-prestigious brand is involved, brand affect is positively influenced. However, these effects are limited to high loyalty consumers only. There was no effect on low loyalty consumers. In a longitudinal study of the Taiwanese market using emails, these hypotheses were tested and supported. Adapted from the source document. JF - International Journal of Consumer Studies AU - Shen, Yung-Cheng AU - Chi, Chung-Hsing AU - Chen, Ja-Shen AD - Department of Business Administration, Yuan-ze University, Nei-Li, Taoyuan, Taiwan Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 385 EP - 390 PB - Blackwell Publishing, Malden, MA VL - 31 IS - 4 SN - 1470-6423, 1470-6423 KW - Promotion KW - Prices KW - Moderator variables KW - Consumers KW - Loyalty KW - Brands KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57226387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Consumer+Studies&rft.atitle=A+new+perspective+on+the+effects+of+price+promotions+in+Taiwan%3A+a+longitudinal+study+of+a+Chinese+society&rft.au=Shen%2C+Yung-Cheng%3BChi%2C+Chung-Hsing%3BChen%2C+Ja-Shen&rft.aulast=Shen&rft.aufirst=Yung-Cheng&rft.date=2007-01-01&rft.volume=31&rft.issue=4&rft.spage=385&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Consumer+Studies&rft.issn=14706423&rft_id=info:doi/10.1111%2Fj.1470-6431.2006.00569.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-05-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Brands; Consumers; Loyalty; Prices; Promotion; Moderator variables DO - http://dx.doi.org/10.1111/j.1470-6431.2006.00569.x ER - TY - JOUR T1 - IMAGEN: IMPLICATIONS FOR ADDICTION SCIENCE AND SCIENCE POLICY AN - 57226129; 200806827 AB - Abstract not provided by publisher. JF - Addiction AU - Heilig, Markus AD - Clinical Director, NIAAA, 10 Center Drive, 10/1-5334, Bethesda, MD 20892-1108, USA. : Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1699 EP - 1700 PB - Blackwell Publishing, Oxford UK VL - 102 IS - 11 SN - 0965-2140, 0965-2140 KW - Science policy KW - Addiction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57226129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=IMAGEN%3A+IMPLICATIONS+FOR+ADDICTION+SCIENCE+AND+SCIENCE+POLICY&rft.au=Heilig%2C+Markus&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2007-01-01&rft.volume=102&rft.issue=11&rft.spage=1699&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/10.1111%2Fj.1360-0443.2007.02004.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ADICE5 N1 - SubjectsTermNotLitGenreText - Addiction; Science policy DO - http://dx.doi.org/10.1111/j.1360-0443.2007.02004.x ER - TY - JOUR T1 - Dynamic mapping of cortical development before and after the onset of pediatric bipolar illness AN - 57219776; 200806634 AB - Background: There are, to date, no pre-post onset longitudinal imaging studies of bipolar disorder at any age. We report the first prospective study of cortical brain development in pediatric bipolar illness for 9 male children, visualized before and after illness onset. Method:We contrast this pattern with that observed in a matched group of healthy children as well as in a matched group of 8 children with 'atypical psychosis' who had similar initial presentation marked by mood dysregulation and transient psychosis (labeled as 'multi-dimensionally impaired' (MDI)) as in the bipolar group, but have not, to date, developed bipolar illness. Results: Dynamic maps, reconstructed by applying novel cortical pattern matching algorithms, for the children who became bipolar I showed subtle, regionally specific, bilaterally asymmetrical cortical changes. Cortical GM increased over the left temporal cortex and decreased bilaterally in the anterior (and sub genual) cingulate cortex. This was seen most strikingly after the illness onset, and showed a pattern distinct from that seen in childhood onset schizophrenia. The bipolar neurodevelopmental trajectory was generally shared by the children who remained with MDI diagnosis without converting to bipolar I, suggesting that this pattern of cortical development may reflect affective dysregulation (lability) in general. Conclusions: These dynamic trajectories of cortical development may explain age-related disparate findings from cross-sectional studies of bipolar illness, and suggest the importance of mood disordered non-bipolar control group in future studies. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Gogtay, Nitin AU - Ordonez, Anna AU - Herman, David H AU - Hayashi, Kiralee M AU - Greenstein, Deanna AU - Vaituzis, Cathy AU - Lenane, Marge AU - Clasen, Liv AU - Sharp, Wendy AU - Giedd, Jay N AU - Jung, David AU - Nugent, Tom F, III AU - Toga, Arthur W AU - Leibenluft, Ellen AU - Thompson, Paul M AU - Rapoport, Judith L AD - Child Psychiatry Branch gogtayn@intra.nimh.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 852 EP - 862 PB - Blackwell Publishing, Oxford UK VL - 48 IS - 9 SN - 0021-9630, 0021-9630 KW - Onset KW - Affective disorders KW - Bipolar affective disorder KW - Brain imaging KW - Children KW - Cortical malformation KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57219776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Dynamic+mapping+of+cortical+development+before+and+after+the+onset+of+pediatric+bipolar+illness&rft.au=Gogtay%2C+Nitin%3BOrdonez%2C+Anna%3BHerman%2C+David+H%3BHayashi%2C+Kiralee+M%3BGreenstein%2C+Deanna%3BVaituzis%2C+Cathy%3BLenane%2C+Marge%3BClasen%2C+Liv%3BSharp%2C+Wendy%3BGiedd%2C+Jay+N%3BJung%2C+David%3BNugent%2C+Tom+F%2C+III%3BToga%2C+Arthur+W%3BLeibenluft%2C+Ellen%3BThompson%2C+Paul+M%3BRapoport%2C+Judith+L&rft.aulast=Gogtay&rft.aufirst=Nitin&rft.date=2007-01-01&rft.volume=48&rft.issue=9&rft.spage=852&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2007.01747.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2015-12-01 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Cortical malformation; Brain imaging; Bipolar affective disorder; Children; Affective disorders; Onset DO - http://dx.doi.org/10.1111/j.1469-7610.2007.01747.x ER - TY - JOUR T1 - Specificity of facial expression labeling deficits in childhood psychopathology AN - 57197323; 200806725 AB - Background: We examined whether face-emotion labeling deficits are illness-specific or an epiphenomenon of generalized impairment in pediatric psychiatric disorders involving mood and behavioral dysregulation. Method: Two hundred fifty-two youths (7-18 years old) completed child and adult facial expression recognition subtests from the Diagnostic Analysis of Nonverbal Accuracy (DANVA) instrument. Forty-two participants had bipolar disorder (BD), 39 had severe mood dysregulation (SMD; i.e., chronic irritability, hyperarousal without manic episodes), 44 had anxiety and/or major depressive disorders (ANX/MDD), 35 had attention-deficit/hyperactivity and/or conduct disorder (ADHD/CD), and 92 were controls. Dependent measures were number of errors labeling happy, angry, sad, or fearful emotions. Results: BD and SMD patients made more errors than ANX/MDD, ADHD/CD, or controls when labeling adult or child emotional expressions. BD and SMD patients did not differ in their emotion-labeling deficits. Conclusions: Face-emotion labeling deficits differentiate BD and SMD patients from patients with ANX/MDD or ADHD/CD and controls. The extent to which such deficits cause vs. result from emotional dysregulation requires further study. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry AU - Guyer, Amanda E AU - McClure, Erin B AU - Adler, Abby D AU - Brotman, Melissa A AU - Rich, Brendan A AU - Kimes, Alane S AU - Pine, Daniel S AU - Ernst, Monique AU - Leibenluft, Ellen AD - Mood and Anxiety Program (MAP), National Institute of Mental Health (NIMH), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Bethesda, MD, USA amandaguyer@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 863 EP - 871 PB - Blackwell Publishing, Oxford UK VL - 48 IS - 9 SN - 0021-9630, 0021-9630 KW - Labelling KW - Facial expressions KW - Affective disorders KW - Attention deficit hyperactivity disorder KW - Emotion recognition KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57197323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry&rft.atitle=Specificity+of+facial+expression+labeling+deficits+in+childhood+psychopathology&rft.au=Guyer%2C+Amanda+E%3BMcClure%2C+Erin+B%3BAdler%2C+Abby+D%3BBrotman%2C+Melissa+A%3BRich%2C+Brendan+A%3BKimes%2C+Alane+S%3BPine%2C+Daniel+S%3BErnst%2C+Monique%3BLeibenluft%2C+Ellen&rft.aulast=Guyer&rft.aufirst=Amanda&rft.date=2007-01-01&rft.volume=48&rft.issue=9&rft.spage=863&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2007.01758.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-04-02 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Attention deficit hyperactivity disorder; Affective disorders; Facial expressions; Children; Labelling; Emotion recognition DO - http://dx.doi.org/10.1111/j.1469-7610.2007.01758.x ER - TY - JOUR T1 - DSM-IV alcohol dependence and abuse: Further evidence of validity in the general population AN - 57189435; 200713069 AB - Background: In order to understand the validity of the Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) alcohol abuse and dependence diagnoses, studies are needed in both clinical and general population samples. The purpose of this study was to examine the construct and criterion-oriented validity of DSM-IV alcohol dependence and abuse in the general population with respect to factor structure and their relationship to family history of alcoholism, treatment utilization, and psychiatric comorbidity. Methods: This analysis is based on data from the 2001-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), in which nationally representative data were collected in personal interviews conducted with one randomly selected adult in each sample household or group quarters. A subset (n = 26,946) of the NESARC sample (total n = 43,093) who reported drinking one or more drinks during the year preceding the interview formed the basis of analyses. Latent variable modeling was used to assess the concurrent validity of DSM-IV alcohol abuse and dependence symptom items. Results: The latent variable modeling yielded one major factor related to alcohol dependence, a second factor related to alcohol abuse and a third smaller factor defined by tolerance. The validity of alcohol dependence in general population samples was further supported by statistically significant associations with family history of alcoholism, treatment utilization, and psychiatric and medical comorbidities. Conclusions: The factor structure and relationship to external criterion variables observed in the study provide support for the further validity of DSM-IV alcohol dependence in the general population, whereas support for the validity of DSM-IV abuse was equivocal. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Grant, Bridget F AU - Harford, Thomas C AU - Muthen, Bengt O AU - Yi, Hsiao-ye AU - Hasin, Deborah S AU - Stinson, Frederick S AD - Laboratory Epidemiology & Biometry, Division Intramural Clinical & Biological Research, National Instit Health, Bethesda, MD bgrant@willco.niaaa.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 154 EP - 166 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 86 IS - 2-3 SN - 0376-8716, 0376-8716 KW - DSM-IV, Alcohol dependence, Alcohol abuse, MIMIC model, Validity KW - Diagnostic and Statistical Manual IV KW - Diagnosis KW - Alcohol abuse KW - Validity KW - Alcohol dependence KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57189435?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=DSM-IV+alcohol+dependence+and+abuse%3A+Further+evidence+of+validity+in+the+general+population&rft.au=Grant%2C+Bridget+F%3BHarford%2C+Thomas+C%3BMuthen%2C+Bengt+O%3BYi%2C+Hsiao-ye%3BHasin%2C+Deborah+S%3BStinson%2C+Frederick+S&rft.aulast=Grant&rft.aufirst=Bridget&rft.date=2007-01-01&rft.volume=86&rft.issue=2-3&rft.spage=154&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.05.019 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Alcohol dependence; Alcohol abuse; Diagnostic and Statistical Manual IV; Validity; Diagnosis DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.05.019 ER - TY - JOUR T1 - Serotonergic responsiveness in human cocaine users AN - 57189294; 200713014 AB - Background: Animal experiments show that repeated cocaine injections induce changes in brain serotonin (5-hydroxytryptamine, or 5-HT) function which can be detected by altered neuroendocrine responsiveness to serotonergic drug challenge. Studies of human cocaine users given a serotonergic challenge have produced inconsistent results. Methods: Hormone responses evoked by the 5-HT releaser D,L-fenfluramine (FEN) were examined in eight human cocaine users who resided on a closed research ward. FEN (60 mg oral) was given after a 7-day cocaine-free period and 3 days after a 5-day period of daily double-blind administration of intranasal cocaine (96 mg) and active placebo (4 mg cocaine). Plasma cortisol and prolactin levels were measured after FEN challenges, and after cocaine and placebo administration. Results: Cocaine significantly elevated plasma cortisol levels to a similar degree on the first and fifth days of administration, but did not alter prolactin levels on either day. The first FEN challenge significantly increased plasma prolactin and cortisol, whereas the second challenge increased only prolactin. Conclusions: Intranasal cocaine increases plasma cortisol without affecting prolactin, with no evidence for tolerance. The reduction in FEN-induced cortisol secretion after cocaine exposure suggests that deficits in 5-HT transmission during early cocaine abstinence might contribute to the maintenance of drug dependence. [Copyright 2006 Elsevier Ireland Ltd.] JF - Drug and Alcohol Dependence AU - Ghitza, Udi E AU - Rothman, Richard B AU - Gorelick, David A AU - Henningfield, Jack E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, IRP, NIDA, NIH, Baltimore, MD Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 207 EP - 213 PB - Elsevier Ireland, Amsterdam The Netherlands VL - 86 IS - 2-3 SN - 0376-8716, 0376-8716 KW - Abstinence, Cocaine, Cortisol, Fenfluramine, Prolactin, Serotonin KW - Prolactin KW - Brain serotonin KW - Drug abusers KW - Plasma levels KW - Cortisol KW - Cocaine KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57189294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Serotonergic+responsiveness+in+human+cocaine+users&rft.au=Ghitza%2C+Udi+E%3BRothman%2C+Richard+B%3BGorelick%2C+David+A%3BHenningfield%2C+Jack+E%3BBaumann%2C+Michael+H&rft.aulast=Ghitza&rft.aufirst=Udi&rft.date=2007-01-01&rft.volume=86&rft.issue=2-3&rft.spage=207&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.06.007 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - DADEDV N1 - SubjectsTermNotLitGenreText - Drug abusers; Cocaine; Brain serotonin; Plasma levels; Cortisol; Prolactin DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.06.007 ER - TY - JOUR T1 - Four Paradigms of Clinical Research and Research Oversight AN - 57160841; 200708930 AB - Delineates four periods & attendant paradigms of clinical biomedical research & ethical oversight in the US from the early 1940s through the mid 1990s: researcher paternalism, regulatory protectionism, participant access, & community partnership. Overlaps between paradigms & scandals or crises marking the transition from one paradigm to the next are described & directions for the future are discussed. Tables. K. Hyatt Stewart JF - Cambridge Quarterly of Healthcare Ethics AU - Emanuel, Ezekiel J AU - Grady, Christine AD - W.G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 82 EP - 96 PB - Cambridge University Press, New York NY VL - 16 IS - 1 SN - 0963-1801, 0963-1801 KW - Clinical research KW - Biomedicine KW - Historical perspectives KW - Paternalism KW - Models KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57160841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cambridge+Quarterly+of+Healthcare+Ethics&rft.atitle=Four+Paradigms+of+Clinical+Research+and+Research+Oversight&rft.au=Emanuel%2C+Ezekiel+J%3BGrady%2C+Christine&rft.aulast=Emanuel&rft.aufirst=Ezekiel&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=82&rft.isbn=&rft.btitle=&rft.title=Cambridge+Quarterly+of+Healthcare+Ethics&rft.issn=09631801&rft_id=info:doi/10.1017%2FS0963180107070090 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Historical perspectives; Clinical research; Models; Biomedicine; Paternalism DO - http://dx.doi.org/10.1017/S0963180107070090 ER - TY - JOUR T1 - A Cross-National Comparison of Youth Risk Behaviors in Latino Secondary School Students Living in El Salvador and the USA AN - 57151851; 200711990 AB - Objectives. As Latin Americans' exposure to the USA increases through migration patterns and US political and economic ties to their countries of origin, they become susceptible to adopting not only the cultural expressions of the USA such as fashion, but also the health-related behaviors of the US population. In assessing potential health risks for Salvadoran youth that may result from the connection between Latin Americans and the USA, this study compared the prevalence of health risk behaviors from four behavior domains (aggression and victimization, depression and suicidal ideation, substance use, and sexual behavior) between Salvadoran and US Latino secondary school students aged 14-17 years. Design. A secondary analysis was performed on two 1999 cross-sectional survey data. In the USA, results were based on 1,063 Latino high school students who answered the nationally representative Youth Risk Behavior Survey (YRBS) conducted by the Centers for Disease Control and Prevention. In El Salvador, results were based on 793 public secondary school students who answered a local YRBS survey conducted in coordination with the Ministry of Education of El Salvador. Results. The prevalence rates for aggression/victimization and for depression and suicidal ideation behaviors were similar between Salvadoran and US Latino adolescents. Substance use prevalence, however, was 10-40% higher for US Latino adolescents. While the prevalence of sexual intercourse was higher among US Latino youth (between 13 and 27% higher, depending on age), the prevalence of condom use was lower among sexually active Salvadoran youth (between 11 and 42% lower, depending on age). Conclusions. In the context of the transnationalization of the Salvadoran population, with potential for increased influence of the USA in Salvadoran culture, these differences in risk behavior are important for targeting effective interventions for Latino adolescents in El Salvador and in the USA. Adapted from the source document. JF - Ethnicity & Health AU - Springer, Andrew AU - Kelder, Steve AU - Orpinas, Pamela AU - Baumler, Elizabeth AD - National Cancer Institute Postdoctoral Fellow, The U Texas School Public Health, Center Health Promotion & Prevention Research, Houston, TX Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 69 EP - 88 PB - Taylor & Francis, Abingdon UK VL - 12 IS - 1 SN - 1355-7858, 1355-7858 KW - Adolescents, Risk Behavior, El Salvador, Latin America, Cross-National, Suicide, Aggression, Drugs, Sexual Behaviors KW - Latin American people KW - Risk behaviour KW - El Salvadorean people KW - Drug abuse KW - Adolescents KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57151851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ethnicity+%26+Health&rft.atitle=A+Cross-National+Comparison+of+Youth+Risk+Behaviors+in+Latino+Secondary+School+Students+Living+in+El+Salvador+and+the+USA&rft.au=Springer%2C+Andrew%3BKelder%2C+Steve%3BOrpinas%2C+Pamela%3BBaumler%2C+Elizabeth&rft.aulast=Springer&rft.aufirst=Andrew&rft.date=2007-01-01&rft.volume=12&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=Ethnicity+%26+Health&rft.issn=13557858&rft_id=info:doi/10.1080%2F13557850601002155 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - CODEN - ETHEFR N1 - SubjectsTermNotLitGenreText - Latin American people; Adolescents; Risk behaviour; El Salvadorean people; Health behaviour; Drug abuse DO - http://dx.doi.org/10.1080/13557850601002155 ER - TY - JOUR T1 - The Impact of Partner Alcohol Problems on Women's Physical and Mental Health AN - 57089256; 200801803 AB - Objective: The purpose of this study was to examine the association between partner alcohol problems and selected physical and mental health outcomes among married or cohabiting women, before and after adjusting for potential confounders, and to compare these associations with those reflecting the impact of the women's own alcohol-use disorders (AUDs). Method: This analysis is based on data from the Wave 1 200 1-2002 National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a cross-sectional, retrospective survey of a nationally representative sample of U.S. adults 18 years of age and older. The analytic sample consisted of 11,683 married or cohabiting women. Classification of their own AUDs was based on self-report of symptoms operationalizing the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), criteria for alcohol abuse or dependence. Current partner alcohol problems were identified by the women after an explanation that recapitulated the essence of these criteria. Physical health measures included criminal victimization of any type, injury, emergency-department and hospital visits, self-reported fair or poor health, and Short Form-12 Health Survey Questionnaire, Version 2 (SF-12v2), -based physical quality of life. Mental health measures included DSM-IV mood and anxiety disorders, number of past-year stressors, and SF-l 2v2-based mental/psychological quality life. All measures refer to the 12 months immediately preceding the interview. Associations were tested using bivariate and multivariate 101 and linear regression models. Results: At the bivariate level, which whose partners had alcohol problems were more likely to experience victimization, injury, mood disorders, anxiety disorders, and being fair or poor health than women whose partners did not have alcohol problems (odds ratio [OR]: 1.7-4.5). They also experienced more stressors and had lower mental/psychological quality-of-life scores but one of these differences remained significant after adjusting for potential confounders, which included the significantly greater rates of stance use and AUDs among women whose partners had alcohol problems. Although the magnitudes of the ORs decreased after adjustment (adjusted OR [AOR]: 2.1-3.4), they generally exceeded the A associated with the women's own AUDs. Conclusions: Partner ale problems pose diverse health threats for women that go beyond well-documented association with domestic violence. Mood, an stress, general health, and quality-of-life problems should be address by groups that provide couples' treatment or counseling to female partners of alcoholics. Adapted from the source document. JF - Journal of Studies on Alcohol and Drugs AU - Dawson, Deborah A AU - Grant, Bridget F AU - Chou, S Patricia AU - Stinson, Frederick S AD - Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health NIAAA/LEB Room 3071, 5635 Fishers Lane, MSC 9304, Bethesda, Maryland 20892-9304 ddawson@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 66 EP - 75 PB - Center of Alcohol Studies, Rutgers, The State University of New Jersey, Piscataway VL - 68 IS - 1 SN - 1937-1888, 1937-1888 KW - Partners KW - Alcohol abuse KW - Women KW - Health status KW - Problem drinking KW - Victimization KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57089256?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Studies+on+Alcohol+and+Drugs&rft.atitle=The+Impact+of+Partner+Alcohol+Problems+on+Women%27s+Physical+and+Mental+Health&rft.au=Dawson%2C+Deborah+A%3BGrant%2C+Bridget+F%3BChou%2C+S+Patricia%3BStinson%2C+Frederick+S&rft.aulast=Dawson&rft.aufirst=Deborah&rft.date=2007-01-01&rft.volume=68&rft.issue=1&rft.spage=66&rft.isbn=&rft.btitle=&rft.title=Journal+of+Studies+on+Alcohol+and+Drugs&rft.issn=19371888&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2008-02-04 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Women; Health status; Alcohol abuse; Problem drinking; Partners; Victimization ER - TY - JOUR T1 - Effects of Mild Early Life Stress on Abnormal Emotion-related Behaviors in 5-HTT Knockout Mice AN - 57076006; 200720266 AB - A low-expressing polymorphic variant of the serotonin transporter (5-HTT) gene has been associated with emotional disorders in humans and non-human primates following exposure to early life trauma. 5-HTT gene knockout (KO) mice exhibit increased anxiety- and depression-related behaviors, and provide a model to study interactions between 5-HTT gene variation and early life stress. The present study assessed the effects of postnatal footshock stress on the development of emotion-related behaviors in 5-HTT KO mice. Results showed that 5-HTT KO mice displayed a profile of suppressed exploratory behavior and increased anxiety- like behavior in the light/dark, elevated plus-maze and open field tests, as well as increased depression-related behavior in the forced swim test following repeated exposure to the test. Postnatal exposure to footshock stress did not affect emotion-related behaviors in non- mutant C57BL/6J mice or modify phenotypic abnormalities in 5-HTT KO. Data provide further evidence of emotional abnormalities following genetic disruption of the 5-HTT. Adapted from the source document. JF - Behavior Genetics AU - Carroll, Jenna C AU - Boyce-Rustay, Janel M AU - Millstein, Rachel AU - Yang, Rebecca AU - Wiedholz, Lisa M AU - Murphy, Dennis L AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, Bethesda, Rockville, MD 20852, USA E-mail: holmesan@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 214 EP - 222 PB - Springer Science+Business Media, Inc, New York, NY VL - 37 IS - 1 SN - 0001-8244, 0001-8244 KW - 5-HT, Serotonin transporter, Anxiety, Depression Gene, Mouse KW - Genes KW - Depression KW - Anxiety KW - Laboratory research KW - Serotonin KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57076006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Behavior+Genetics&rft.atitle=Effects+of+Mild+Early+Life+Stress+on+Abnormal+Emotion-related+Behaviors+in+5-HTT+Knockout+Mice&rft.au=Carroll%2C+Jenna+C%3BBoyce-Rustay%2C+Janel+M%3BMillstein%2C+Rachel%3BYang%2C+Rebecca%3BWiedholz%2C+Lisa+M%3BMurphy%2C+Dennis+L%3BHolmes%2C+Andrew&rft.aulast=Carroll&rft.aufirst=Jenna&rft.date=2007-01-01&rft.volume=37&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Behavior+Genetics&rft.issn=00018244&rft_id=info:doi/10.1007%2Fs10519-006-9129-9 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - BHGHAT N1 - SubjectsTermNotLitGenreText - Anxiety; Depression; Laboratory research; Genes; Serotonin DO - http://dx.doi.org/10.1007/s10519-006-9129-9 ER - TY - JOUR T1 - Associations of perceived risk and worry with cancer health-protective actions: data from the Health Information National Trends Survey (HINTS) AN - 36664911; 3420634 AB - This study examined the associations of susceptibility, conceptualized as both a cognition (risk) and as affect (worry) and their possible interaction, with cancer screening behaviors. Data for this study were obtained from the 2003 Health Information National Trends Survey (HINTS). Hierarchical regression models assessed the ability of risk, worry and their interaction (after controlling for other important variables) to predict cancer-screening behaviors. Results found that risk and worry (but not their interaction) were associated with regular mammography screening and having had a sigmoidoscopy or colonoscopy but with neither FOBT nor PSA screening. The findings suggest that risk and worry are both important in predicting some types of screening behavior and that these variables operate independently. Reprinted by permission of Sage Publications Ltd JF - Journal of health psychology AU - Moser, Richard P AU - McCaul, Kevin AU - Peters, Ellen AU - Nelson, Wendy AU - Marcus, Stephen E AD - National Cancer Institute ; North Dakota State University ; University of Oregon Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 53 EP - 65 VL - 12 IS - 1 SN - 1359-1053, 1359-1053 KW - Sociology KW - Risk KW - Medical sociology KW - Perception KW - Regression analysis KW - Data analysis KW - Cancer KW - Behavioural sciences KW - Health promotion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36664911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Associations+of+perceived+risk+and+worry+with+cancer+health-protective+actions%3A+data+from+the+Health+Information+National+Trends+Survey+%28HINTS%29&rft.au=Moser%2C+Richard+P%3BMcCaul%2C+Kevin%3BPeters%2C+Ellen%3BNelson%2C+Wendy%3BMarcus%2C+Stephen+E&rft.aulast=Moser&rft.aufirst=Richard&rft.date=2007-01-01&rft.volume=12&rft.issue=1&rft.spage=53&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105307071735 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7887 12008; 1542 11325; 3279 971 3286; 10739 12228 10919; 1939 3617 6220; 5790 5772; 9382; 11035 DO - http://dx.doi.org/10.1177/1359105307071735 ER - TY - JOUR T1 - Recent studies on the stages of change model AN - 36662455; 3420748 JF - Journal of health psychology AU - Joekes, Katherine AU - Elderen, Thérèse Van AU - Schreurs, Karlein AU - Mulholland, Ellen AU - Wersch, Anna Van AU - Hanson, Margaret D AU - Chen, Edith AU - Priest, Penny AU - Moser, Richard P AU - McCaul, Kevin AU - Peters, Ellen AU - Nelson, Wendy AU - Marcus, Stephen E AU - Blaine, Bruce E AU - Rodman, Jennifer AU - Newman, Jennifer M AU - Beauchamp, Mark R AU - Welch, Amy S AU - Hulley, Angie J AU - Pakenham, Kenneth I AU - Chiu, Jessica AU - Bursnall, Samantha AU - Cannon, Toni AU - Gooden, Rebecca J AU - Winefield, Helen R AU - Ekelund, Marie-Louise AU - Andersson, Sven Ingmar AU - Lafrance, Michelle N AU - Rutter, Claire L AU - Rutter, Derek R AU - Armitage, Christopher J AU - Arden, Madelynne A AU - Lawrence, Wendy T AU - Prochaska, James O AU - Prochaska, Janice M AU - Marter, Deborah Van AU - Johnson, Janet L AU - Wallace, Louise M AU - Evers, Kerry E AU - Wareing, Hilary AU - Dunn, Orla M AU - Newby, Kate AU - Paiva, Andrea AU - Whyshall, Zara J AU - Haslam, Cheryl AU - Haslam, Roger AD - Leiden University ; Roessingh Rehabilitation Centre, The Netherlands ; University of Teesside ; University of British Columbia ; University of Birmingham ; National Cancer Institute ; North Dakota State University ; University of Oregon ; St John Fisher College ; Hofstra University ; University of Leeds ; University of Queensland ; Griffith University ; Carers Queensland ; University of Adelaide ; Lund University ; St Thomas University ; University of Kent ; University of Sheffield ; Sheffield Hallam University ; University of Southampton ; University of Rhode Island ; Pro-Change Behavior Systems ; Coventry University ; Public Management Associates ; Loughborough University Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 4 EP - 200 VL - 12 IS - 1 SN - 1359-1053, 1359-1053 KW - Sociology KW - Self-evaluation KW - Medical sociology KW - Socioeconomic status KW - Substance use KW - Health services KW - Public health KW - Smoking KW - Behaviourism KW - Attitudes KW - Caring KW - Medical treatment KW - Group dynamics KW - Health promotion KW - Quality of life KW - Obesity KW - Social psychology KW - Mental stress KW - Adolescence KW - Well-being KW - Gender differentiation KW - Patients KW - Stigma KW - United Kingdom KW - Family studies KW - Sex education KW - Prevention KW - Contraception KW - Social support KW - Perception KW - Mental health KW - Occupations KW - Bullying KW - Leadership KW - Work place UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36662455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Recent+studies+on+the+stages+of+change+model&rft.au=Joekes%2C+Katherine%3BElderen%2C+Th%C3%A9r%C3%A8se+Van%3BSchreurs%2C+Karlein%3BMulholland%2C+Ellen%3BWersch%2C+Anna+Van%3BHanson%2C+Margaret+D%3BChen%2C+Edith%3BPriest%2C+Penny%3BMoser%2C+Richard+P%3BMcCaul%2C+Kevin%3BPeters%2C+Ellen%3BNelson%2C+Wendy%3BMarcus%2C+Stephen+E%3BBlaine%2C+Bruce+E%3BRodman%2C+Jennifer%3BNewman%2C+Jennifer+M%3BBeauchamp%2C+Mark+R%3BWelch%2C+Amy+S%3BHulley%2C+Angie+J%3BPakenham%2C+Kenneth+I%3BChiu%2C+Jessica%3BBursnall%2C+Samantha%3BCannon%2C+Toni%3BGooden%2C+Rebecca+J%3BWinefield%2C+Helen+R%3BEkelund%2C+Marie-Louise%3BAndersson%2C+Sven+Ingmar%3BLafrance%2C+Michelle+N%3BRutter%2C+Claire+L%3BRutter%2C+Derek+R%3BArmitage%2C+Christopher+J%3BArden%2C+Madelynne+A%3BLawrence%2C+Wendy+T%3BProchaska%2C+James+O%3BProchaska%2C+Janice+M%3BMarter%2C+Deborah+Van%3BJohnson%2C+Janet+L%3BWallace%2C+Louise+M%3BEvers%2C+Kerry+E%3BWareing%2C+Hilary%3BDunn%2C+Orla+M%3BNewby%2C+Kate%3BPaiva%2C+Andrea%3BWhyshall%2C+Zara+J%3BHaslam%2C+Cheryl%3BHaslam%2C+Roger&rft.aulast=Joekes&rft.aufirst=Katherine&rft.date=2007-01-01&rft.volume=12&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 18 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 11474 4551; 13530 13521; 10525 12162 3898; 9271 7890 5792 10484; 7887 12008; 5792 10484; 12258 11762 11859 11856; 1378 10404; 11988 4011 3974 9390 11932 2328 11935 5837 2360 2688 2449 10404 11936; 12357; 590 652 5676 646 6091; 4783; 11901 10404; 5648 5636 5676 971; 7947 5772 7954; 9382; 5790 5772; 8823; 7890 5792 10484; 7271 1411; 1543; 7953 7954; 2039 13521; 8864; 11938 11949 13521; 5423 3549 2688 2449 10404; 1829 6823; 11755 5707 6071 1542 11325; 10072; 11548 4049; 2836 1636 1635 11574; 10449 5772; 13673 4214; 438 462 129 302 ER - TY - JOUR T1 - Mixture cure survival models with dependent censoring AN - 36660345; 3428121 AB - The paper is motivated by cure detection among the prostate cancer patients in the National Institutes of Health surveillance epidemiology and end results programme, wherein the main end point (e.g. deaths from prostate cancer) and the censoring causes (e.g. deaths from heart diseases) may be dependent. Although many researchers have studied the mixture survival model to analyse survival data with non-negligible cure fractions, none has studied the mixture cure model in the presence of dependent censoring. To account for such dependence, we propose a more general cure model that allows for dependent censoring. We derive the cure models from the perspective of competing risks and model the dependence between the censoring time and the survival time by using a class of Archimedean copula models. Within this framework, we consider the parameter estimation, the cure detection and the two-sample comparison of latency distributions in the presence of dependent censoring when a proportion of patients is deemed cured. Large sample results by using martingale theory are obtained. We examine the finite sample performance of the proposed methods via simulation and apply them to analyse the surveillance epidemiology and end results prostate cancer data. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Li, Y. AU - Tiwari, R C AU - Guha, S AD - Harvard University ; National Cancer Institute, Bethesda Y1 - 2007 PY - 2007 DA - 2007 SP - 285 EP - 306 VL - 69 IS - 3 SN - 1369-7412, 1369-7412 KW - Sociology KW - Health KW - Patients KW - Censuses KW - Statistical methods KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36660345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Mixture+cure+survival+models+with+dependent+censoring&rft.au=Li%2C+Y.%3BTiwari%2C+R+C%3BGuha%2C+S&rft.aulast=Li&rft.aufirst=Y.&rft.date=2007-01-01&rft.volume=69&rft.issue=3&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 9271 7890 5792 10484; 5772; 2105 12429; 12228 10919 ER - TY - JOUR T1 - Estimating efficacy in a proposed randomized trial with initial and later non-compliance AN - 36613702; 3397346 AB - A controversial topic in obstetrics is the effect of walking on the probability of Caesarean section among women in labour. A major reason for the controversy is the presence of non-compliance that complicates the estimation of efficacy, the effect of treatment received on outcome. The intent-to-treat method does not estimate efficacy, and estimates of efficacy that are based directly on treatment received may be biased because they are not protected by randomization. However, when non-compliance occurs immediately after randomization, the use of a potential outcomes model with reasonable assumptions has made it possible to estimate efficacy and still to retain the benefits of randomization to avoid selection bias. In this obstetrics application, non-compliance occurs initially and later in one arm. Consequently some parameters cannot be uniquely estimated without making strong assumptions. This difficulty is circumvented by a new study design involving an additional randomization group and a novel potential outcomes model (principal stratification). Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Baker, S G AU - Frangakis, C AU - Lindeman, K S AD - National Institutes of Health, Bethesda ; Johns Hopkins University, Baltimore ; Johns Hopkins Medical Institution, Baltimore Y1 - 2007 PY - 2007 DA - 2007 SP - 211 EP - 222 VL - 56 IS - 2 SN - 0035-9254, 0035-9254 KW - Sociology KW - Medical research KW - Women KW - Statistical models KW - Estimation KW - Statistical methods KW - Pregnancy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36613702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Estimating+efficacy+in+a+proposed+randomized+trial+with+initial+and+later+non-compliance&rft.au=Baker%2C+S+G%3BFrangakis%2C+C%3BLindeman%2C+K+S&rft.aulast=Baker&rft.aufirst=S&rft.date=2007-01-01&rft.volume=56&rft.issue=2&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=00359254&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 12228 10919; 12230 8163; 7886 10902; 10020; 13598 5421 6091; 4403 7854 ER - TY - JOUR T1 - Maximum likelihood inference on a mixed conditionally and marginally specified regression model for genetic epidemiologic studies with two-phase sampling AN - 36599363; 3385594 AB - Two-phase stratified sampling designs can reduce the cost of genetic epidemiologic studies by limiting expensive ascertainments of genetic and environmental exposure to an efficiently selected subsample (phase II) of the main study (phase I). Family history and some covariate information, which may be cheaply gathered for all subjects at phase I, can be used for sampling of informative subjects at phase II. We develop alternative maximum likelihood methods for analysis of data from such studies by using a novel regression model that permits the estimation of `marginal' risk parameters that are associated with the genetic and environmental covariates of interest, while simultaneously characterizing the `conditional' risk of the disease associated with family history after adjusting for the other covariates. The methods and appropriate asymptotic theories are developed with and without an assumption of gene-environment independence, allowing the distribution of the environmental factors to remain non-parametric. The performance of the alternative methods and of sampling strategies is studied by using simulated data involving rare and common genetic variants. An application of the methods proposed is illustrated by using a case-control study of colorectal adenoma embedded within the prostate, lung, colorectal and ovarian cancer screening trial. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Chatterjee, N AU - Chen, Y H AD - National Cancer Institute ; Academia Sinica Y1 - 2007 PY - 2007 DA - 2007 SP - 123 EP - 142 VL - 69 IS - 2 SN - 1369-7412, 1369-7412 KW - Economics KW - Environment KW - Data collection KW - Human genetics KW - Epidemiology KW - Family history KW - Regression analysis KW - Health KW - Statistical methods KW - Data analysis KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36599363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Maximum+likelihood+inference+on+a+mixed+conditionally+and+marginally+specified+regression+model+for+genetic+epidemiologic+studies+with+two-phase+sampling&rft.au=Chatterjee%2C+N%3BChen%2C+Y+H&rft.aulast=Chatterjee&rft.aufirst=N&rft.date=2007-01-01&rft.volume=69&rft.issue=2&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4357 7894; 6081 5460 1615 8573 11325; 4309; 3286; 3279 971 3286; 12228 10919; 10739 12228 10919; 1939 3617 6220; 4767 5889; 5772 ER - TY - JOUR T1 - The insignificance of choice and Wallace's normative approach to responsibility AN - 36595902; 3388844 JF - Law and philosophy AU - Litton, P AD - National Institutes of Health Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 67 EP - 93 VL - 26 IS - 1 SN - 0167-5249, 0167-5249 KW - Political Science KW - Responsibility KW - Ethics KW - Law KW - Philosophy KW - Philosophy of law UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36595902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Law+and+philosophy&rft.atitle=The+insignificance+of+choice+and+Wallace%27s+normative+approach+to+responsibility&rft.au=Litton%2C+P&rft.aulast=Litton&rft.aufirst=P&rft.date=2007-01-01&rft.volume=26&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Law+and+philosophy&rft.issn=01675249&rft_id=info:doi/10.1007%2Fs10982-006-0001-0 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 10970; 9490 7253 9486; 4408 8282 8281 6085; 7253; 9486 DO - http://dx.doi.org/10.1007/s10982-006-0001-0 ER - TY - JOUR T1 - Empirical-likelihood-based inference in missing response problems and its application in observational studies AN - 36568568; 3371071 AB - The problem of missing response data is ubiquitous in medical and social science studies. In the case of responses that are missing at random (depending on some covariate information), analyses focused only on the complete data may lead to biased results. Various debias methods have been extensively studied in the literature, particularly the weighting method that was motivated by Horvitz and Thompson's estimators. To improve efficiency, Robins, Rotnitzky and Zhao proposed augmented estimating equations based on corrected complete-case analyses. A nice feature of the augmented method is its `double robustness', i.e. the estimator that is derived from the augmented method is asymptotically unbiased if either the underlying missing data mechanism or the underlying regression function is correctly specified. Furthermore, the augmented estimator can achieve full efficiency if both the missing data mechanism and the regression function are correctly specified. In general, however, it is very difficult to specify the regression function correctly, especially when the dimension of covariates is high-this is the so-called curse of dimensionality problem. The augmented estimator has much lower efficiency if the 'working regression model' is not close to the true regression model. In this paper, the empirical likelihood method is employed to seek a constrained empirical likelihood estimation of mean response with the assumption that responses are missing at random. The empirical-likelihood-based estimators enjoy the double-robustness property. Moreover, it is possible that the empirical-likelihood-based inference can produce asymptotically unbiased and efficient estimators even if the true regression function is not completely known. Simulation results indicate that the empirical-likelihood-based estimators are very robust to a misspecification of the propensity score and dominate other competitors in the sense of having smaller mean-square errors. Methods that are developed in this paper have a nice application in observational causal inferences. The propensity score is used to adjust for differences in pretreatment variables in the estimation of average treatment effects. Reprinted by permission of Blackwell Publishers JF - Journal of the Royal Statistical Society AU - Qin, J AU - Zhang, B AD - National Institute of Allergy and Infectious Diseases ; University of Toledo Y1 - 2007 PY - 2007 DA - 2007 SP - 101 EP - 122 VL - 69 IS - 1 SN - 1369-7412, 1369-7412 KW - Sociology KW - Statistics KW - Research methods KW - Empirical research KW - Statistical methods KW - Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36568568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Royal+Statistical+Society&rft.atitle=Empirical-likelihood-based+inference+in+missing+response+problems+and+its+application+in+observational+studies&rft.au=Qin%2C+J%3BZhang%2C+B&rft.aulast=Qin&rft.aufirst=J&rft.date=2007-01-01&rft.volume=69&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Royal+Statistical+Society&rft.issn=13697412&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 4200 10902; 7994; 10919; 12233; 12228 10919 ER - TY - JOUR T1 - Claudin proteins in ovarian cancer AN - 21352628; 8720038 AB - Members of the claudin family of tight junction proteins have been found altered in several malignancies, including ovarian cancer. Because claudin-3 and -4 are elevated in the vast majority of ovarian tumors, they may represent useful biomarkers for detection and prognosis, as well as ideal targets for therapy using the Clostridium perfringens enterotoxin. JF - Disease Markers AU - Morin, Patrice J AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA. Tel.: +1 410 558 8506; Fax: +1 410 558 8386; E-mail: Morinp[at]grc.nia.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 453 EP - 457 PB - IOS Press, Nieuwe Hemweg 6B VL - 23 IS - 5,6 SN - 0278-0240, 0278-0240 KW - Microbiology Abstracts B: Bacteriology KW - Ovarian cancer KW - Malignancy KW - Tight junctions KW - Clostridium perfringens KW - Prognosis KW - Enterotoxins KW - Tumors KW - biomarkers KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21352628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Disease+Markers&rft.atitle=Claudin+proteins+in+ovarian+cancer&rft.au=Morin%2C+Patrice+J&rft.aulast=Morin&rft.aufirst=Patrice&rft.date=2007-01-01&rft.volume=23&rft.issue=5%2C6&rft.spage=453&rft.isbn=&rft.btitle=&rft.title=Disease+Markers&rft.issn=02780240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Malignancy; Tight junctions; Prognosis; Enterotoxins; Tumors; biomarkers; Clostridium perfringens ER - TY - JOUR T1 - Role of Interleukin 10 during Persistent Infection with the Relapsing Fever Spirochete Borrelia turicatae AN - 21321792; 11664942 AB - Relapsing fever is an infection characterized by peaks of spirochetemia attributable to antibody selection against variable serotypes. In the absence of B cells, serotypes cannot be cleared, resulting in persistent infection. We previously identified differences in spirochetemia and disease severity during persistent infection of severe combined immunodeficiency mice with isogenic serotypes 1 (Bt1) or 2 (Bt2) of Borrelia turicatae. To investigate this further, we studied pathogen load, clinical disease, cytokine/chemokine production, and inflammation in mice deficient in B (Igh6 super(-/-)) or B and T (Rag1 super(-/-)) cells persistently infected with Bt1 or Bt2. The results showed that Igh6 super(-/-) mice, despite lower spirochetemia, had a significantly aggravated disease course compared with Rag1 super(-/-) mice. Measurement of cytokines revealed a significant positive correlation between pathogen load and interleukin (IL)-10 in blood, brain, and heart. Bt2-infected Rag1 super(-/-) mice harbored the highest spirochetemia and, at the same time, displayed the highest IL-10 plasma levels. In the brain, Bt1, which was five times more neurotropic than Bt2, caused higher IL-10 production. Activated microglia were the main source of IL-10 in brain. IL-10 injected systemically reduced disease and spirochetemia. The results suggest IL-10 plays a protective role as a down-regulator of inflammation and pathogen load during infection with relapsing fever spirochetes. JF - American Journal of Pathology AU - Gelderblom, H AU - Schmidt, J AU - Londono, D AU - Bai, Y AU - Quandt, J AU - Hornung, R AU - Marques, A AU - Martin, R AU - Cadavid, D AD - Cellular Immunology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 251 EP - 262 VL - 170 IS - 1 SN - 0002-9440, 0002-9440 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Heart KW - Chemokines KW - Serotypes KW - Lymphocytes B KW - Relapsing fever KW - Brain KW - Pathogens KW - Microglia KW - Borrelia turicatae KW - Persistent infection KW - Interleukin 10 KW - Inflammation KW - Blood KW - Spirochetes KW - Antibodies KW - Plasma levels KW - Cytokines KW - Severe combined immunodeficiency KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21321792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Role+of+Interleukin+10+during+Persistent+Infection+with+the+Relapsing+Fever+Spirochete+Borrelia+turicatae&rft.au=Gelderblom%2C+H%3BSchmidt%2C+J%3BLondono%2C+D%3BBai%2C+Y%3BQuandt%2C+J%3BHornung%2C+R%3BMarques%2C+A%3BMartin%2C+R%3BCadavid%2C+D&rft.aulast=Gelderblom&rft.aufirst=H&rft.date=2007-01-01&rft.volume=170&rft.issue=1&rft.spage=251&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2007.060407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Heart; Chemokines; Serotypes; Lymphocytes B; Relapsing fever; Brain; Pathogens; Microglia; Interleukin 10; Persistent infection; Inflammation; Spirochetes; Blood; Plasma levels; Antibodies; Cytokines; Severe combined immunodeficiency; Borrelia turicatae DO - http://dx.doi.org/10.2353/ajpath.2007.060407 ER - TY - JOUR T1 - Press Release: Study Identifies Common Flaws in Oncology Microarray Studies AN - 21290317; 7253596 JF - Journal of the National Cancer Institute AU - Widener, Andrea AD - 301-841-1287 , Journal of the National Cancer Institute, jncimedia@oxfordjournals.org Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 97 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 2 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - Oncology KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21290317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Press+Release%3A+Study+Identifies+Common+Flaws+in+Oncology+Microarray+Studies&rft.au=Widener%2C+Andrea&rft.aulast=Widener&rft.aufirst=Andrea&rft.date=2007-01-01&rft.volume=99&rft.issue=2&rft.spage=97&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Oncology ER - TY - JOUR T1 - Value Added by Data Sharing: Long-Term Potentiation of Neuroscience Research AN - 21220725; 11280723 AB - Abstract not available. JF - Neuroinformatics AU - Liu, Yuan AU - Ascoli, Giorgio A AD - NINDS, NIH, Bethesda, MD, USA, liuyuan@ninds.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 143 EP - 145 PB - Humana Press Inc., 999 Riverview Dr., Ste. 208 Totowa NJ 07512 USA VL - 5 IS - 3 SN - 1539-2791, 1539-2791 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Nervous system KW - Data processing KW - J1T KW - Long-term potentiation KW - Bioinformatics KW - J1L KW - N3 11029:Neurophysiology & biophysics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21220725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroinformatics&rft.atitle=Value+Added+by+Data+Sharing%3A+Long-Term+Potentiation+of+Neuroscience+Research&rft.au=Liu%2C+Yuan%3BAscoli%2C+Giorgio+A&rft.aulast=Liu&rft.aufirst=Yuan&rft.date=2007-01-01&rft.volume=5&rft.issue=3&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Neuroinformatics&rft.issn=15392791&rft_id=info:doi/10.1007%2Fs12021-007-0009-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - J1T; J1L; Long-term potentiation; Data processing; Nervous system; Bioinformatics DO - http://dx.doi.org/10.1007/s12021-007-0009-0 ER - TY - JOUR T1 - The biologic basis of in vivo angiogenesis imaging AN - 21161797; 11275924 AB - Knowledge of the different physiology and endothelial markers present in tumor vessels is essential to enable both the development of new anti-angiogenic chemotherapeutic agents and of more specific imaging techniques. Tumor blood vessels are disorganized, irregular in caliber, tortuous, and do not have specialized features of normal arterioles, capillaries or venules. Neo-angiogenic tumor vessels have large gaps between or through cells, loose pericytes, and discontinuities or redundant layers within the basement membrane, rendering these vessels hyper-permeable. Furthermore, the endothelia of tumor vessels may express unique markers on their surface. Imaging is becoming increasingly important in the evaluation of angiogenesis. Clinical imaging is minimally invasive and enables sampling of the whole tumor in a nondestructive manner. The patterns of increased permeability seen on Dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) mirror the known ultrastructural defects associated with angiogenic vessels. Conventional low-molecular weight contrast agents are currently in clinical use for DCE-MRI studies and have proven successful in detecting changes related to novel angiogenic inhibitors. However, they are relatively nonspecific. Macromolecular contrast media may be more suitable for imaging tumor vessels. It is hoped that imaging modalities can be adapted to specifically target markers expressed on the endothelium of tumor vessels. The number of cell surface markers of angiogenesis is relatively low, and only small amounts of contrast agents can bind to these receptors; currently only Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) tracers have sufficient sensitivity to allow detection at this low level. Despite limitations in their spatial resolution, PET and SPECT imaging are more likely to enter the clinic as targeted angiogenesis imaging methods. The quest for selective targets on the tumor vasculature continues, currently the integrin family of receptors offer the most promise but other targets are being pursued by investigators. Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis. JF - Frontiers in Bioscience AU - Ocak, I AU - Baluk, P AU - Barrett, T AU - McDonald, D M AU - Choyke, P AD - Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 3601 EP - 3616 VL - 12 SN - 1093-9946, 1093-9946 KW - Biotechnology and Bioengineering Abstracts KW - Cell surface KW - Macromolecules KW - Serial analysis of gene expression KW - Chemotherapy KW - Phage display KW - Magnetic resonance imaging KW - Angiogenesis KW - pericytes KW - spatial discrimination KW - Tumors KW - Capillaries KW - Single photon emission computed tomography KW - Tracers KW - Permeability KW - Blood vessels KW - Basement membranes KW - Integrins KW - Endothelium KW - Positron emission tomography KW - Contrast media KW - Sampling KW - Arterioles KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21161797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+Bioscience&rft.atitle=The+biologic+basis+of+in+vivo+angiogenesis+imaging&rft.au=Ocak%2C+I%3BBaluk%2C+P%3BBarrett%2C+T%3BMcDonald%2C+D+M%3BChoyke%2C+P&rft.aulast=Ocak&rft.aufirst=I&rft.date=2007-01-01&rft.volume=12&rft.issue=&rft.spage=3601&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+Bioscience&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Tumors; Angiogenesis; Single photon emission computed tomography; Contrast media; Positron emission tomography; Macromolecules; Sampling; Chemotherapy; Serial analysis of gene expression; Magnetic resonance imaging; spatial discrimination; Endothelium; Permeability; Basement membranes; Blood vessels; Phage display; Capillaries; Arterioles; Tracers; Cell surface; Integrins; pericytes ER - TY - JOUR T1 - Neural network models of tinnitus AN - 21061948; 8581736 AB - In this chapter we review the relatively recent effort on the part of neuroscientists to use computational neural network modeling to investigate the neural basis of subjective tinnitus. There are advantages and challenges in using a modeling framework to understand this complex auditory disorder. The foremost challenge to modeling a subjective condition such as tinnitus is the evaluation of the occurrence of tinnitus in the model. We propose comparing measures of the model's activities (simulated neuronal activity, behavioral activity, or neuroimaging activity) with experimental data obtained from studies of tinnitus in humans and animals; strong agreement with experimental data will provide support for the validity of the simulation of tinnitus in a particular model. A major advantage of neural network modeling is that it allows experimentation not possible in animals. Models make it possible to evaluate the contribution of different neural mechanisms affecting tinnitus in a principled manner. A model makes predictions that can be tested by experiments thus leading to the designing of focused experiments. We review several neural models of tinnitus and discuss published findings from simulations using these models. We conclude with a proposed scheme for investigating tinnitus that combines neural network modeling with brain imaging experiments. JF - Progress in Brain Research AU - Husain, Fatima T AD - Brain Imaging and Modeling Section, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bldg. 10, Rm 8S235D, MSC 1407, 9000 Rockville Pike, Bethesda, MD 20892, USA, husainf@nidcd.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 125 EP - 140 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl] VL - 166 SN - 0079-6123, 0079-6123 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - neuroimaging KW - electrophysiological KW - fMRI KW - auditory KW - cerebral cortex KW - thalamus KW - Neuroimaging KW - Data processing KW - Neural networks KW - Reviews KW - Animal models KW - Tinnitus KW - Computational neuroscience KW - N3 11002:Computational & theoretical neuroscience KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21061948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Progress+in+Brain+Research&rft.atitle=Neural+network+models+of+tinnitus&rft.au=Husain%2C+Fatima+T&rft.aulast=Husain&rft.aufirst=Fatima&rft.date=2007-01-01&rft.volume=166&rft.issue=&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Progress+in+Brain+Research&rft.issn=00796123&rft_id=info:doi/10.1016%2FS0079-6123%2807%2966011-7 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Data processing; Neural networks; Reviews; Animal models; Tinnitus; Computational neuroscience DO - http://dx.doi.org/10.1016/S0079-6123(07)66011-7 ER - TY - JOUR T1 - Production of adenoviral vectors and its recovery AN - 21059914; 8566295 AB - The current demands for adenoviral vectors are increasing to satisfy pre- clinical and clinical gene therapy protocols. Consequently, there is a necessity of methodologies to improve production and recovery of intact particles with the minimum effect upon bioactivity. The production of adenoviral vectors in HEK 293 cells and the potential of an alternative aqueous two-phase system (ATPS) composed of PEG 300-phosphate in recovery of adenoviral vectors were investigated. The production of adenoviral vectors was carried out using a 2 L bioreactor equipped with two Rushton impellers. Different parameters including initial cell density, harvesting time and the addition of a buffer (HEPES) were studied in order to improve the production of adenoviral vectors in HEK 293 cells. A yield of 8 x 10 super(11) infective particles was achieved under the conditions characterized by the addition of Pluronic F-68, inoculation at an initial cell density of 3.5 x 10 super(5) cells/mL and harvest of infected cells at 48 h post infection (hpi). This material was used for the evaluation of the ATPS recovery processes. It was demonstrated that the chemical components of the ATPS did not have a significant effect upon the infectivity of the adenoviral vectors and a total recovery of approximately 90% was obtained. These findings contribute to the process development for the manufacture of adenoviral vectors and other nanoparticulate bioproducts. JF - Process Biochemistry AU - Negrete, Alejandro AU - Ling, Tau Chuan AU - Lyddiatt, Andrew AD - Biochemical Recovery Group, Department of Chemical Engineering, School of Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK, negretea@nhlbi.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1107 EP - 1113 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 42 IS - 7 SN - 1359-5113, 1359-5113 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Adenoviral vectors KW - HEK 293 KW - ATPS KW - Yield KW - Recovery KW - Expression vectors KW - Infectivity KW - Gene therapy KW - Bioreactors KW - Cell density KW - Inoculation KW - ATP KW - Infection KW - nanoparticles KW - Polyethylene glycol KW - W 30905:Medical Applications KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21059914?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Process+Biochemistry&rft.atitle=Production+of+adenoviral+vectors+and+its+recovery&rft.au=Negrete%2C+Alejandro%3BLing%2C+Tau+Chuan%3BLyddiatt%2C+Andrew&rft.aulast=Negrete&rft.aufirst=Alejandro&rft.date=2007-01-01&rft.volume=42&rft.issue=7&rft.spage=1107&rft.isbn=&rft.btitle=&rft.title=Process+Biochemistry&rft.issn=13595113&rft_id=info:doi/10.1016%2Fj.procbio.2007.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Expression vectors; Infectivity; Gene therapy; Bioreactors; Cell density; Inoculation; ATP; Infection; Polyethylene glycol; nanoparticles DO - http://dx.doi.org/10.1016/j.procbio.2007.05.004 ER - TY - JOUR T1 - Discovering functional linkages and uncharacterized cellular pathways using phylogenetic profile comparisons: a comprehensive assessment AN - 21001080; 9022919 AB - Background A widely-used approach for discovering functional and physical interactions among proteins involves phylogenetic profile comparisons (PPCs). Here, proteins with similar profiles are inferred to be functionally related under the assumption that proteins involved in the same metabolic pathway or cellular system are likely to have been co-inherited during evolution. Results Our experimentation with E. coli and yeast proteins with 16 different carefully composed reference sets of genomes revealed that the phyletic patterns of proteins in prokaryotes alone could be adequate enough to make reasonably accurate functional linkage predictions. A slight improvement in performance is observed on adding few eukaryotes into the reference set, but a noticeable drop-off in performance is observed with increased number of eukaryotes. Inclusion of most parasitic, pathogenic or vertebrate genomes and multiple strains of the same species into the reference set do not necessarily contribute to an improved sensitivity or accuracy. Interestingly, we also found that evolutionary histories of individual pathways have a significant affect on the performance of the PPC approach with respect to a particular reference set. For example, to accurately predict functional links in carbohydrate or lipid metabolism, a reference set solely composed of prokaryotic (or bacterial) genomes performed among the best compared to one composed of genomes from all three super-kingdoms; this is in contrast to predicting functional links in translation for which a reference set composed of prokaryotic (or bacterial) genomes performed the worst. We also demonstrate that the widely used random null model to quantify the statistical significance of profile similarity is incomplete, which could result in an increased number of false-positives. Conclusion Contrary to previous proposals, it is not merely the number of genomes but a careful selection of informative genomes in the reference set that influences the prediction accuracy of the PPC approach. We note that the predictive power of the PPC approach, especially in eukaryotes, is heavily influenced by the primary endosymbiosis and subsequent bacterial contributions. The over-representation of parasitic unicellular eukaryotes and vertebrates additionally make eukaryotes less useful in the reference sets. Reference sets composed of highly non-redundant set of genomes from all three super-kingdoms fare better with pathways showing considerable vertical inheritance and strong conservation (e.g. translation apparatus), while reference sets solely composed of prokaryotic genomes fare better for more variable pathways like carbohydrate metabolism. Differential performance of the PPC approach on various pathways, and a weak positive correlation between functional and profile similarities suggest that caution should be exercised while interpreting functional linkages inferred from genome-wide large-scale profile comparisons using a single reference set. JF - BMC Bioinformatics AU - Jothi, Raja AU - Przytycka, Teresa M AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, jothi@ncbi.nlm.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 173 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Phylogeny KW - Genomes KW - Translation KW - Carbohydrate metabolism KW - Statistics KW - Heredity KW - Statistical analysis KW - Lipid metabolism KW - Escherichia coli KW - Metabolic pathways KW - Conservation KW - Prokaryotes KW - Carbohydrates KW - Bioinformatics KW - J 02320:Cell Biology KW - G 07770:Bacteria KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21001080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Discovering+functional+linkages+and+uncharacterized+cellular+pathways+using+phylogenetic+profile+comparisons%3A+a+comprehensive+assessment&rft.au=Jothi%2C+Raja%3BPrzytycka%2C+Teresa+M%3BAravind%2C+L&rft.aulast=Jothi&rft.aufirst=Raja&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=173&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-173 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Genomes; Phylogeny; Translation; Carbohydrate metabolism; Statistics; Heredity; Statistical analysis; Lipid metabolism; Metabolic pathways; Conservation; Bioinformatics; Carbohydrates; Prokaryotes; Escherichia coli DO - http://dx.doi.org/10.1186/1471-2105-8-173 ER - TY - JOUR T1 - Two Distinct Cytotoxic Activities of Subtilase Cytotoxin Produced by Shiga-Toxigenic Escherichia coli AN - 20988776; 7207627 AB - Subtilase cytotoxin (SubAB) is a recently identified AB5 subunit toxin produced by Shiga-toxigenic Escherichia coli. The A subunit is thought to be a subtilase-like, serine protease, whereas the B subunit binds to the toxin receptor on the cell surface. We cloned the genes from a clinical isolate; the toxin was produced as His-tagged proteins. SubAB induced vacuolation at concentrations greater than 1 mu g/ml after 8 h, in addition to the reported cytotoxicity induced at a ng/ml level after 48 h. Vacuolation was induced with the B, but not the A, subunit and was dependent on V-type ATPase. The cytotoxicity of SubAB at low concentrations was associated with the inhibition of protein synthesis; the 50% inhibitory dose was similar to 1 ng/ml. The A subunit, containing serine 272, which is thought to be a part of the catalytic triad of a subtilase-like serine protease, plus the B subunit was necessary for this activity, both in vivo and in vitro. SubAB did not cleave azocasein, bovine serum albumin, ovalbumin, or synthetic peptides. These data suggest that SubAB is a unique AB toxin: first, the B subunit alone can induce vacuolation; second, the A subunit containing serine 272 plus the B subunit inhibited protein synthesis, both in vivo and in vitro; and third, the A subunit proteolytic activity may have a strict range of substrate specificity. JF - Infection and Immunity AU - Morinaga, Naoko AU - Yahiro, Kinnosuke AU - Matsuura, Gen AU - Watanabe, Masaharu AU - Nomura, Fumio AU - Moss, Joel AU - Noda, Masatoshi AD - Department of Molecular Infectiology. Department of Pediatric Surgery. Department of Molecular Diagnosis and Clinical Genetics, Graduate School of Medicine. Division of Laboratory Medicine, Chiba University Hospital, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan. Pulmonary-Critical Care Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 488 EP - 496 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 1 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Clinical isolates KW - Cell surface KW - Ovalbumin KW - synthetic peptides KW - Adenosinetriphosphatase KW - Protein biosynthesis KW - Data processing KW - Serine proteinase KW - Cytotoxins KW - subtilase KW - Substrate specificity KW - Azocasein KW - Toxins KW - Cytotoxicity KW - Antibodies KW - Bovine serum albumin KW - Escherichia coli KW - Serine KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20988776?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Two+Distinct+Cytotoxic+Activities+of+Subtilase+Cytotoxin+Produced+by+Shiga-Toxigenic+Escherichia+coli&rft.au=Morinaga%2C+Naoko%3BYahiro%2C+Kinnosuke%3BMatsuura%2C+Gen%3BWatanabe%2C+Masaharu%3BNomura%2C+Fumio%3BMoss%2C+Joel%3BNoda%2C+Masatoshi&rft.aulast=Morinaga&rft.aufirst=Naoko&rft.date=2007-01-01&rft.volume=75&rft.issue=1&rft.spage=488&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Proteolysis; Ovalbumin; Cell surface; Data processing; Protein biosynthesis; Adenosinetriphosphatase; synthetic peptides; Serine proteinase; Cytotoxins; subtilase; Substrate specificity; Azocasein; Toxins; Antibodies; Cytotoxicity; Bovine serum albumin; Serine; Escherichia coli ER - TY - JOUR T1 - Variance of estimated DTI-derived parameters via first-order perturbation methods AN - 20860398; 8368364 AB - In typical applications of diffusion tensor imaging (DTI), DT-derived quantities are used to make a diagnostic, therapeutic, or scientific determination. In such cases it is essential to characterize the variability of these tensor-derived quantities. Parametric and empirical methods have been proposed to estimate the variance of the estimated DT, and quantities derived from it. However, the former method cannot be generalized since a parametric distribution cannot be found for all DT-derived quantities. Although powerful empirical methods, such as the bootstrap, are available, they require oversampling of the diffusion-weighted imaging (DWI) data. Statistical perturbation methods represent a hybrid between parametric and empirical approaches, and can overcome the primary limitations of both methods. In this study we used a first-order perturbation method to obtain analytic expressions for the variance of DT-derived quantities, such as the trace, fractional anisotropy (FA), eigenvalues, and eigenvectors, for a given experimental design. We performed Monte Carlo (MC) simulations of DTI experiments to test and validate these formulae, and to determine their range of applicability for different experimental design parameters, including the signal-to-noise ratio (SNR), diffusion gradient sampling scheme, and number of DWI acquisitions. This information should be useful for designing DTI studies and assessing the quality of inferences drawn from them. JF - Magnetic Resonance in Medicine AU - Chang, Lin-Ching AU - Koay, Cheng Guan AU - Pierpaoli, Carlo AU - Basser, Peter J AD - Section on Tissue Biophysics and Biomimetics, Laboratory of Integrative Medicine and Biophysics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA, changlin@nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 141 EP - 149 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Anisotropy KW - Data processing KW - Statistics KW - Hybrids KW - Magnetic resonance imaging KW - Diffusion KW - N.M.R. KW - Sampling KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Variance+of+estimated+DTI-derived+parameters+via+first-order+perturbation+methods&rft.au=Chang%2C+Lin-Ching%3BKoay%2C+Cheng+Guan%3BPierpaoli%2C+Carlo%3BBasser%2C+Peter+J&rft.aulast=Chang&rft.aufirst=Lin-Ching&rft.date=2007-01-01&rft.volume=57&rft.issue=1&rft.spage=141&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21111 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistics; imaging; Sampling; Data processing; N.M.R.; Diffusion; Anisotropy; Magnetic resonance imaging; Hybrids DO - http://dx.doi.org/10.1002/mrm.21111 ER - TY - JOUR T1 - High-resolution 3D arteriography of chronic total peripheral occlusions using a T1-W turbo spin-echo sequence with inner-volume imaging AN - 20860233; 8368354 AB - Percutaneous revascularization of peripheral artery chronic total occlusion (CTO) is challenging under X-ray guidance without direct image feedback, due to poor visualization of the obstructed segment and underappreciation of vessel tortuosity. Operators are required to steer interventional devices relatively blindly, and therefore procedural failure or perforation may occur. Alternatively, MRI may allow complete visualization of both patent and occluded arterial segments. We designed and implemented a 3D high-resolution, T1-weighted (T1-W) turbo spin-echo (TSE) MRI sequence with inner-volume (IV) imaging to enable detailed peripheral artery CTO imaging. Using this sequence, high-resolution volumes of interest (VOIs) around the vessel were achieved within 5-10 min. This imaging approach may be used for rapid pre- and postprocedural evaluations, and as a 3D roadmap that can be overlaid during real-time X-, MR-, or XMR-guided catheterization. Experiments were successfully performed on a carotid CTO model in swine ex vivo, and in peripheral arteries in normal volunteers and patients in vivo. Delineation of the vascular architecture, including contrast differences between the patent and occluded artery segments, and lesion morphology heterogeneity were visualized. JF - Magnetic Resonance in Medicine AU - Sampath, Smita AU - Raval, Amish N AU - Lederman, Robert J AU - McVeigh, Elliot R AD - Laboratory of Cardiac Energetics, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, sampaths@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 40 EP - 49 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 57 IS - 1 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Catheterization KW - Arteriography KW - Ionizing radiation KW - Occlusion KW - Patents KW - Arteries KW - Magnetic resonance imaging KW - Feedback KW - Vascular system KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=High-resolution+3D+arteriography+of+chronic+total+peripheral+occlusions+using+a+T1-W+turbo+spin-echo+sequence+with+inner-volume+imaging&rft.au=Sampath%2C+Smita%3BRaval%2C+Amish+N%3BLederman%2C+Robert+J%3BMcVeigh%2C+Elliot+R&rft.aulast=Sampath&rft.aufirst=Smita&rft.date=2007-01-01&rft.volume=57&rft.issue=1&rft.spage=40&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21098 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Arteries; Magnetic resonance imaging; Patents; Occlusion; Ionizing radiation; Feedback; Vascular system; Arteriography; Catheterization DO - http://dx.doi.org/10.1002/mrm.21098 ER - TY - JOUR T1 - GST, NAT1, CYP1A1 polymorphisms and risk of esophageal and gastric adenocarcinomas AN - 20739404; 8566939 AB - Background: Polymorphisms in glutathione-S-transferase (GST), N-acetyltransferase (NAT) 1, and CYP1A1 genes have been suggested as susceptibility factors for esophageal and gastric adenocarcinomas, but have not been consistently linked to elevated risks. In a population-based case-control study, we examined risks in relation to polymorphisms of the following genes: GSTP1; GSTM1; GSTT1; NAT1; and CYP1A1. Methods: Histologically confirmed incident cases, ages 30-79, were identified in three US locations. Population controls from the same catchment areas were frequency matched to expected age and sex distributions of esophageal and gastric cardia adenocarcinomas. DNA was extracted from buffy coat for PCR-based assays, with interpretable genotyping results obtained from 209 controls, 67 esophageal adenocarcinomas, 60 gastric cardia adenocarcinomas, and 56 noncardia gastric adenocarcinomas. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated among whites, adjusting for age, sex, and study center. Results: In all histologic subgroups, ORs were somewhat elevated for the GSTP1 Val/Val genotype (versus Ile/Ile), although 95% CIs included 1.00. The respective ORs for esophageal, cardia, and other gastric adenocarcinomas were 1.73 (0.75-4.02), 1.46 (0.57-3.73), and 1.22 (0.48-3.09). No consistent patterns of elevated risk were associated with the null GSTM1 or GSTT1 genotypes, one or two copies of NAT1*10 or *11 alleles, or CYP1A1 Val/Val or Ile/Val genotypes (versus Ile/Ile). Conclusions: Additional research in larger samples is needed to further assess polymorphisms and their interactions with epidemiologic risk factors, particularly for esophageal adenocarcinoma, which has been increasing markedly in incidence. JF - Cancer Detection and Prevention AU - Wideroff, Louise AU - Vaughan, Thomas L AU - Farin, Federico M AU - Gammon, Marilie D AU - Risch, Harvey AU - Stanford, Janet L AU - Chow, Wong-Ho AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, EPN 4005, 6130 Executive Boulevard, 7344, Bethesda, 20892-7344, USA, Wideroff@nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 233 EP - 236 PB - International Society for Preventive Oncology, University of Massachusetts Medical Center 55 Lake Avenue North, Box 20 Worcester MA 01655 USA, [URL:http://www.cancerprev.org/ISPO/] VL - 31 IS - 3 SN - 0361-090X, 0361-090X KW - Risk Abstracts KW - Polymorphism, genetic KW - Cancer risk KW - Gastrointestinal cancer KW - Adenocarcinoma, esophageal KW - Adenocarcinoma, gastric KW - Epidemiology KW - Age KW - prevention KW - DNA KW - Catchments KW - Genotypes KW - Cancer KW - population control KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20739404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Detection+and+Prevention&rft.atitle=GST%2C+NAT1%2C+CYP1A1+polymorphisms+and+risk+of+esophageal+and+gastric+adenocarcinomas&rft.au=Wideroff%2C+Louise%3BVaughan%2C+Thomas+L%3BFarin%2C+Federico+M%3BGammon%2C+Marilie+D%3BRisch%2C+Harvey%3BStanford%2C+Janet+L%3BChow%2C+Wong-Ho&rft.aulast=Wideroff&rft.aufirst=Louise&rft.date=2007-01-01&rft.volume=31&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Cancer+Detection+and+Prevention&rft.issn=0361090X&rft_id=info:doi/10.1016%2Fj.cdp.2007.03.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Age; Catchments; DNA; prevention; Genotypes; population control; Cancer DO - http://dx.doi.org/10.1016/j.cdp.2007.03.004 ER - TY - JOUR T1 - Genetic Polymorphisms in Folate Metabolism and the Risk of Stomach Cancer AN - 20725800; 7251313 AB - Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted DNA synthesis and repair. Enzyme-coding genes involved in folate metabolism are often polymorphic. In a population-based study of 305 cases and 427 controls in Warsaw, Poland, we evaluated the risk of stomach cancer in relation to polymorphisms in folate-metabolizing genes, including MTHFR (Ex5+79C>T and Ex8-62A>C), MTR (Ex26-20A>G), and MTRR (Ex2-64A>G, Ex5+123C>T, Ex15+572C>T, Ex15-405A>T, Ex9-85C>T, Ex15-526G>A, and Ex14+14C>T). Polymorphisms in the MTHFR gene were not associated with stomach cancer risk. No notable effect was found for polymorphisms in MTR or MTRR either, although MTR Ex26-20 A>G and MTRR Ex5+123C>T polymorphisms were associated with a borderline increased risk of stomach cancer (MTR Ex26-20A>G, AG/GG versus AA: odds ratio, 1.35; 95% confidence interval, 0.96-1.90; MTRR Ex5+123C>T, CT/TT versus CC: odds ratio, 1.30; 95% confidence interval, 0.93-1.82). We did not find significant interactions between polymorphisms in MTHFR, MTR, and MTRR genes and dietary folate and alcohol consumption. Our study did not identify strong genetic determinants in the folate metabolism pathway for stomach cancer risk. (Cancer Epidemiol Biomarkers Prev 2007; 16(1):115-21) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Zhang, Fang Fang AU - Terry, Mary Beth AU - Hou, Lifang AU - Chen, Jinbo AU - Lissowska, Jolanta AU - Yeager, Meredith AU - Zatonski, Witold AU - Chanock, Stephen AU - Morabia, Alfredo AU - Chow, Wong-Ho AD - Division of Cancer Epidemiology and Genetics and Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 115 EP - 121 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 1 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Bioindicators KW - Diets KW - Alcohol KW - DNA biosynthesis KW - Etiology KW - Gene polymorphism KW - Population studies KW - Methylenetetrahydrofolate reductase KW - DNA repair KW - biomarkers KW - Cancer KW - Poland KW - DNA KW - prevention KW - DNA methylation KW - Gastric cancer KW - Folic acid KW - Metabolism KW - Ethanol KW - G 07880:Human Genetics KW - N 14820:DNA Metabolism & Structure KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Genetic+Polymorphisms+in+Folate+Metabolism+and+the+Risk+of+Stomach+Cancer&rft.au=Zhang%2C+Fang+Fang%3BTerry%2C+Mary+Beth%3BHou%2C+Lifang%3BChen%2C+Jinbo%3BLissowska%2C+Jolanta%3BYeager%2C+Meredith%3BZatonski%2C+Witold%3BChanock%2C+Stephen%3BMorabia%2C+Alfredo%3BChow%2C+Wong-Ho&rft.aulast=Zhang&rft.aufirst=Fang&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=115&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Etiology; Gene polymorphism; DNA methylation; Population studies; Methylenetetrahydrofolate reductase; DNA repair; Folic acid; Gastric cancer; biomarkers; Metabolism; Ethanol; Diets; Bioindicators; Alcohol; prevention; DNA; Cancer; Poland ER - TY - JOUR T1 - Quantitative evaluation of bacteria released by bathers in a marine water AN - 20723472; 7171115 AB - Enterococci, a common fecal indicator, and Staphylococcus aureus, a common skin pathogen, can be shed by bathers affecting the quality of recreational waters and resulting in possible human health impacts. Due to limited information available concerning human shedding of these microbes, this study focused on estimating the amounts of enterococci and S. aureus shed by bathers directly off their skin and indirectly via sand adhered to skin. Two sets of experiments were conducted at a marine beach located in Miami-Dade County, Florida. The first study, referred to as the "large pool" study, involved 10 volunteers who immersed their bodies in 4700 L during four 15 min cycles with exposure to beach sand in cycles 3 and 4. The "small pool" study involved 10 volunteers who were exposed to beach sand for 30 min before they individually entered a small tub. After each individual was rinsed with off- shore marine water, sand and rinse water were collected and analyzed for enterococci. Results from the "large pool" study showed that bathers shed concentrations of enterococci and S. aureus on the order of 6x10 super(5) and 6x10 super(6) colony forming units (CFU) per person in the first 15 min exposure period, respectively. Significant reductions in the bacteria shed per bather (50% reductions for S. aureus and 40% for enterococci) were observed in the subsequent bathing cycles. The "small pool" study results indicated that the enterococci contribution from sand adhered to skin was small (about 2% of the total) in comparison with the amount shed directly from the bodies of the volunteers. Results indicated that bathers transport significant amounts of enterococci and S. aureus to the water column, and thus human microbial bathing load should be considered as a non-point source when designing recreational water quality models. JF - Water Research AU - Elmir, Samir M AU - Wright, Mary E AU - Abdelzaher, Amir AU - Solo-Gabriele, Helena M AU - Fleming, Lora E AU - Miller, Gary AU - Rybolowik, Michael AU - Shih, Meng-Ta Peter AU - Pillai, Segaran P AU - Cooper, Jennifer A AU - Quaye, Elesi A AD - NSF-NIEHS Oceans and Human Health Center, University of Miami, Rosenstiel School for Marine and Atmospheric Sciences,1801 NW 9 Avenue, Suite 200 (R-669), Miami, Florida 33136, USA, hmsolo@miami.edu Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 3 EP - 10 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl] VL - 41 IS - 1 SN - 0043-1354, 0043-1354 KW - Microbiology Abstracts B: Bacteriology; Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; ASFA Marine Biotechnology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Aqualine Abstracts; Water Resources Abstracts KW - Recreational water KW - Bacteria indicators KW - Enterococci KW - Staphylococcus aureus KW - Bathers KW - Sediments KW - Beach sand KW - Non-point pollution sources KW - Water quality models KW - shores KW - USA, Florida KW - Bathing KW - Pools KW - Shores KW - Water quality KW - Water column KW - Models KW - Public health KW - Evaluation KW - Colonies KW - Sand KW - Exposure KW - Recreational waters KW - ASW, USA, Florida KW - Bacteria KW - Beaches KW - Skin KW - Staphylococcus KW - Pathogens KW - Water pollution KW - Recreation areas KW - Colony-forming cells KW - water column KW - Exposed habitats KW - A 01450:Environmental Pollution & Waste Treatment KW - Q4 27760:Microorganisms KW - P 1000:MARINE POLLUTION KW - AQ 00008:Effects of Pollution KW - SW 3030:Effects of pollution KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Water+Research&rft.atitle=Quantitative+evaluation+of+bacteria+released+by+bathers+in+a+marine+water&rft.au=Elmir%2C+Samir+M%3BWright%2C+Mary+E%3BAbdelzaher%2C+Amir%3BSolo-Gabriele%2C+Helena+M%3BFleming%2C+Lora+E%3BMiller%2C+Gary%3BRybolowik%2C+Michael%3BShih%2C+Meng-Ta+Peter%3BPillai%2C+Segaran+P%3BCooper%2C+Jennifer+A%3BQuaye%2C+Elesi+A&rft.aulast=Elmir&rft.aufirst=Samir&rft.date=2007-01-01&rft.volume=41&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Water+Research&rft.issn=00431354&rft_id=info:doi/10.1016%2Fj.watres.2006.10.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Recreational waters; Bathing; Pathogens; Water pollution; Exposed habitats; Public health; Colonies; Beaches; Skin; Sand; Colony-forming cells; Shores; Water quality; Water column; Models; shores; Recreation areas; water column; Evaluation; Bacteria; Exposure; Staphylococcus; Pools; Staphylococcus aureus; ASW, USA, Florida; USA, Florida DO - http://dx.doi.org/10.1016/j.watres.2006.10.005 ER - TY - JOUR T1 - A Case-Control Investigation of Immune Function Gene Polymorphisms and Risk of Testicular Germ Cell Tumors AN - 20722666; 7251339 AB - There is reason to suspect that testicular germ cell tumor (TGCT) development may be influenced by cytokines, secreted proteins that modulate tumor immune surveillance activity as well as a variety of processes in the testis. To address this hypothesis, we conducted a case-control analysis (508 cases, 608 controls) of 32 putatively functional single-nucleotide polymorphisms (SNP) in 16 immune function genes among non-Hispanic Caucasian participants in the U.S. Servicemen's Testicular Tumor Environmental and Endocrine Determinants Study. The TGFB1 Ex5-73C>T variant was positively associated with TGCT (CT/TT versus CC: odds ratio, 1.73; 95% confidence interval, 1.01-2.95; P sub(trend) = 0.05); additionally, haplotypes of the assessed TGFB1 SNPs (-509C>T, 327C>T, Ex1-282C>G, and Ex5-73C>T) differed in frequency between cases and controls (all TGCT, P 0.07; seminoma, P 0.04; nonseminoma, P 0.11). We also observed excess frequencies among TGCT cases versus controls of LTA 252G (P sub(trend) = 0.08) and of the TNF variants -1042C (P sub(trend) = 0.06), -1036T (P sub(trend) = 0.07), and -238G (P sub(trend) = 0.09). Analyses of haplotypes for LTA-TNF SNPs (LTA -91C>A, LTA 252A>G, TNF -863C>A, TNF -857C>T, TNF -308G>A, and -238G>A) were similarly suggestive of an association with TGCT (P = 0.06) and nonseminoma (P = 0.04), but not seminoma (P = 0.21). Polymorphisms in other genes were found to be associated only with seminoma (IL2) or nonseminoma (IFNGR2 and IL10). However, none of the associations remained noteworthy after applying the false discovery rate method to control for multiple testing. In conclusion, our findings suggest that polymorphisms in TGFB1 and LTA/TNF, and possibly other immune function genes, may influence susceptibility to TGCT. (Cancer Epidemiol Biomarkers Prev 2007; 16(1):77-83) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Purdue, Mark P AU - Sakoda, Lori C AU - Graubard, Barry I AU - Welch, Robert AU - Chanock, Stephen J AU - Sesterhenn, Isabel A AU - Rubertone, Mark V AU - Erickson, RLoren AU - McGlynn, Katherine A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 77 EP - 83 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 16 IS - 1 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Risk Abstracts; Immunology Abstracts KW - Testes KW - Interleukin 2 KW - Gene polymorphism KW - Tumor necrosis factor KW - tumors KW - Interleukin 10 KW - Haplotypes KW - Immunosurveillance KW - prevention KW - Cytokines KW - Bioindicators KW - Transforming growth factor- beta 1 KW - Germ cells KW - haplotypes KW - Tumors KW - biomarkers KW - Cancer KW - USA KW - Single-nucleotide polymorphism KW - Proteins KW - Immune response KW - seminoma KW - G 07880:Human Genetics KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=A+Case-Control+Investigation+of+Immune+Function+Gene+Polymorphisms+and+Risk+of+Testicular+Germ+Cell+Tumors&rft.au=Purdue%2C+Mark+P%3BSakoda%2C+Lori+C%3BGraubard%2C+Barry+I%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BSesterhenn%2C+Isabel+A%3BRubertone%2C+Mark+V%3BErickson%2C+RLoren%3BMcGlynn%2C+Katherine+A&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=77&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Testes; Transforming growth factor- beta 1; Interleukin 2; Tumor necrosis factor; Gene polymorphism; Germ cells; Tumors; biomarkers; Cancer; Interleukin 10; Haplotypes; Single-nucleotide polymorphism; Immunosurveillance; Cytokines; Immune response; seminoma; Bioindicators; prevention; Proteins; tumors; haplotypes; USA ER - TY - JOUR T1 - Simian immunodeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft AN - 20703431; 7632486 AB - X-linked chronic granulomatous disease (X-CGD) is a primary immunodeficiency caused by mutations in the phagocyte nicotinamide dinucleotide phosphate oxidase catalytic subunit gp91 super(phox). Gene therapy targeting hematopoietic stem cells (HSCs) can correct CGD, but permanent correction remains a challenge. Lentiviral vectors have become attractive tools for gene transfer, and they may have the potential to transduce very primitive HSCs. We used a self-inactivating RD114/TR-pseudotyped simian immunodeficiency virus (SIVmac)-based vector encoding human gp91 super(phox) for ex vivo transduction of peripheral blood-mobilized stem cells (PBSCs) from patients with X-CGD. In PBSCs from two patients, ex vivo transduction efficiencies of 40.5 and 46% were achieved, and correction of oxidase activity was observed in myeloid cells differentiating in culture. When transduced PBSCs from these patients were transplanted into nonobese diabetic/severe combined immunodeficient mice and compared to normal control, 10.5 and 7.3% of the human myeloid cells in bone marrow developing at 6 weeks from the human xenografts expressed the gp91 super(phox) transgene. Sustained functional correction of oxidase activity was documented in myeloid cells differentiated from engrafted transduced PBSCs. Transgene marking was polyclonal as assessed by vector integration site analysis. These data suggest that RD114/TR SIVmac-based vectors might be suitable for gene therapy of CGD and other hereditary hematologic diseases. JF - Gene Therapy AU - Naumann, N AU - De Ravin, S S AU - Choi, U AU - Moayeri, M AU - Whiting-Theobald, N AU - Linton, G F AU - Ikeda, Y AU - Malech, H L AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, hmalech@niaid.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1513 EP - 1524 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 14 IS - 21 SN - 0969-7128, 0969-7128 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - chronic granulomatous disease KW - lentiviral vector KW - simian immunodeficiency virus KW - Gp91 super(phox) KW - hematopoietic stem cell KW - RD114 KW - Data processing KW - Gene therapy KW - nicotinamide KW - X chromosome KW - Transgenes KW - Bone marrow KW - Immunodeficiency KW - Catalytic subunits KW - Cell culture KW - Myeloid cells KW - Transgenic mice KW - Expression vectors KW - Diabetes mellitus KW - Integration KW - Stem cells KW - Phosphate KW - Phagocytes KW - Severe combined immunodeficiency KW - Xenografts KW - Chronic granulomatous disease KW - Mutation KW - Simian immunodeficiency virus KW - Bone marrow transplantation KW - W 30905:Medical Applications KW - V 22360:AIDS and HIV KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20703431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Simian+immunodeficiency+virus+lentivector+corrects+human+X-linked+chronic+granulomatous+disease+in+the+NOD%2FSCID+mouse+xenograft&rft.au=Naumann%2C+N%3BDe+Ravin%2C+S+S%3BChoi%2C+U%3BMoayeri%2C+M%3BWhiting-Theobald%2C+N%3BLinton%2C+G+F%3BIkeda%2C+Y%3BMalech%2C+H+L&rft.aulast=Naumann&rft.aufirst=N&rft.date=2007-01-01&rft.volume=14&rft.issue=21&rft.spage=1513&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fsj.gt.3303010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Gene therapy; nicotinamide; Transgenes; X chromosome; Immunodeficiency; Bone marrow; Catalytic subunits; Cell culture; Transgenic mice; Myeloid cells; Diabetes mellitus; Expression vectors; Integration; Stem cells; Phosphate; Phagocytes; Severe combined immunodeficiency; Xenografts; Chronic granulomatous disease; Mutation; Bone marrow transplantation; Simian immunodeficiency virus DO - http://dx.doi.org/10.1038/sj.gt.3303010 ER - TY - JOUR T1 - Development of recombinant adeno-associated virus vectors carrying small interfering RNA (shHec1)-mediated depletion of kinetochore Hec1 protein in tumor cells AN - 20702490; 7441383 AB - Transcript depletion using small interfering RNA (siRNA) technology represents a potentially valuable technique for the treatment of cancer. However, delivering therapeutic quantities of siRNA into solid tumors by chemical transfection is not feasible, whereas viral vectors efficiently transduce many human tumor cell lines. Yet producing sufficient quantities of viral vectors that elicit acute and selective cytotoxicity remains a major obstacle for preclinical and clinical trials. Using the invertebrate Spodoptera frugiperda (Sf9) cell line, we were able to produce high titer stocks of cytotoxic recombinant adeno-associated virus (rAAV) that express short hairpin RNA (shRNA) and that efficiently deplete Hec1 (highly expressed in cancer 1), or Kntc2 (kinetochore-associated protein 2), a kinetochore protein directly involved in kinetochore microtubule interactions, chromosome congression and spindle checkpoint signaling. Depletion of Hec1 protein results in persistent spindle checkpoint activation followed by cell death. Because Hec1 expression and activity are only present in mitotic cells, non-dividing cells were not affected by rAAV treatment. On the basis of the results of screening 56 human tumor cell lines with three different serotype vectors, we used a tumor xenograft model to test the effects in vivo. The effects of the shHec1 vector were evident in sectioned and stained tumors. The experiments with rAAV- shRNA vectors demonstrate the utility of producing vectors in invertebrate cells to obtain sufficient concentrations and quantities for solid tumor therapy. This addresses an important requirement for cancer gene therapy, to produce cytotoxic vectors in sufficient quantities and concentrations to enable quantitative transduction and selective killing of solid tumor cells. JF - Gene Therapy AU - Li, L AU - Yang, L AU - Scudiero, D A AU - Miller, S A AU - Yu, Z-X AU - Stukenberg, P T AU - Shoemaker, R H AU - Kotin, R M AD - Laboratory of Biochemical Genetics, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA, kotinr@nhlbi.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 814 EP - 827 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 14 IS - 10 SN - 0969-7128, 0969-7128 KW - Fall armyworm KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Entomology Abstracts KW - rAAV KW - Hec1 KW - RNA interference KW - cancer BEV KW - baculovirus expression vector KW - CGNS KW - cerebella granule neurons KW - CNS KW - central nervous system KW - dsRNA KW - double-strand RNA KW - eGFP KW - enhanced green fluorescence protein KW - highly expressed in cancer 1 KW - hrGFP KW - humanized Renilla green fluorescence protein KW - HSPG KW - heparan sulfate proteogylcans KW - kmts KW - kinetochore microtubles KW - Kntc2 KW - kinetochore-associated protein 2 KW - MOI KW - multiplicity of infection (encapsidated vector genome particles per cell) KW - recombinant adeno-associated virus KW - RNAi KW - Sf KW - Spodoptera frugiperda KW - shRNA KW - short hairpin RNA KW - siRNA KW - small interfering RNA KW - Microtubules KW - Serotypes KW - Gene therapy KW - Solid tumors KW - Transcription KW - Tumors KW - Clinical trials KW - Adeno-associated virus KW - Cancer KW - Cell activation KW - Expression vectors KW - Spindles KW - Cytotoxicity KW - Tumor cell lines KW - Chromosomes KW - Cell death KW - Transfection KW - Kinetochores KW - Xenografts KW - Signal transduction KW - W 30925:Genetic Engineering KW - N 14830:RNA KW - Z 05330:Reproduction and Development KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20702490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene+Therapy&rft.atitle=Development+of+recombinant+adeno-associated+virus+vectors+carrying+small+interfering+RNA+%28shHec1%29-mediated+depletion+of+kinetochore+Hec1+protein+in+tumor+cells&rft.au=Li%2C+L%3BYang%2C+L%3BScudiero%2C+D+A%3BMiller%2C+S+A%3BYu%2C+Z-X%3BStukenberg%2C+P+T%3BShoemaker%2C+R+H%3BKotin%2C+R+M&rft.aulast=Li&rft.aufirst=L&rft.date=2007-01-01&rft.volume=14&rft.issue=10&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Gene+Therapy&rft.issn=09697128&rft_id=info:doi/10.1038%2Fsj.gt.3302933 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Microtubules; Serotypes; Gene therapy; Solid tumors; Transcription; Tumors; Clinical trials; Cancer; Cell activation; Expression vectors; Cell death; Chromosomes; Tumor cell lines; Cytotoxicity; Spindles; siRNA; Kinetochores; Transfection; Xenografts; Signal transduction; Spodoptera frugiperda; Adeno-associated virus DO - http://dx.doi.org/10.1038/sj.gt.3302933 ER - TY - JOUR T1 - Intentional Exposure Studies of Environmental Agents on Human Subjects: Assessing Benefits and Risks 1 AN - 20700329; 10308439 AB - In this article, I assess the benefits and risks of studies that intentionally expose research subjects to environmental agents. I describe these types of studies, identify their benefits and risks, compare them to other research methods that can be used to investigate the relationship between environmental exposures and disease, and discuss some issues related to research design and risk minimization. I argue that the benefits of intentional environmental exposure studies outweigh the risks when 1) the knowledge gained is likely to improve our understanding of the relationship between environmental exposure and disease, 2) this knowledge cannot be obtained by other methods, 3) the experiments are well designed, 4) the subjects will receive some benefits, such as medical evaluations, 5) risks are minimized, and 6) the risks to human subjects are less than those encountered in a typical Phase I drug study. Only in rare circumstances (i.e., when an intentional environmental exposure study is needed to implement an important environmental or public health intervention or regulation) may such studies expose research subjects to risks as high as those encountered in a typical Phase I drug trail. JF - Accountability in Research AU - Resnik, D B AD - National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 35 EP - 55 VL - 14 IS - 1 SN - 0898-9621, 0898-9621 KW - Risk Abstracts KW - risk reduction KW - research methods KW - research design KW - intervention KW - accountability KW - Drugs KW - Public health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20700329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accountability+in+Research&rft.atitle=Intentional+Exposure+Studies+of+Environmental+Agents+on+Human+Subjects%3A+Assessing+Benefits+and+Risks+1&rft.au=Resnik%2C+D+B&rft.aulast=Resnik&rft.aufirst=D&rft.date=2007-01-01&rft.volume=14&rft.issue=1&rft.spage=35&rft.isbn=&rft.btitle=&rft.title=Accountability+in+Research&rft.issn=08989621&rft_id=info:doi/10.1080%2F08989620601122842 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-08-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; research methods; intervention; research design; accountability; Drugs; Public health DO - http://dx.doi.org/10.1080/08989620601122842 ER - TY - JOUR T1 - Identifying Biomarkers from Mass Spectrometry Data with Ordinal Outcome AN - 20667877; 9420473 AB - Summary: In recent years, there has been an increased interest in using protein mass spectroscopy to identify molecular markers that discriminate diseased from healthy individuals. Existing methods are tailored towards classifying observations into nominal categories. Sometimes, however, the outcome of interest may be measured on an ordered scale. Ignoring this natural ordering results in some loss of information. In this paper, we propose a Bayesian model for the analysis of mass spectrometry data with ordered outcome. The method provides a unified approach for identifying relevant markers and predicting class membership. This is accomplished by building a stochastic search variable selection method within an ordinal outcome model. We apply the methodology to mass spectrometry data on ovarian cancer cases and healthy individuals. We also utilize wavelet-based techniques to remove noise from the mass spectra prior to analysis. We identify protein markers associated with being healthy, having low grade ovarian cancer, or being a high grade case. For comparison, we repeated the analysis using conventional classification procedures and found improved predictive accuracy with our method. JF - Cancer Informatics AU - Kwon, Deukwoo AU - Tadesse, Mahlet G AU - Sha, Naijun AU - Pfeiffer, Ruth M AU - Vannucci, Marina AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, U.S.A Y1 - 2007 PY - 2007 DA - 2007 SP - 19 EP - 28 PB - Libertas Academica, PO Box 300-874 VL - 3 SN - 1176-9351, 1176-9351 KW - Biotechnology and Bioengineering Abstracts KW - Markov chain Monte Carlo KW - mass spectrometry KW - ordinal outcome KW - variable selection KW - Ovarian cancer KW - Data processing KW - Mathematical models KW - Informatics KW - Bayesian analysis KW - Stochasticity KW - biomarkers KW - Mass spectroscopy KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20667877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Informatics&rft.atitle=Identifying+Biomarkers+from+Mass+Spectrometry+Data+with+Ordinal+Outcome&rft.au=Kwon%2C+Deukwoo%3BTadesse%2C+Mahlet+G%3BSha%2C+Naijun%3BPfeiffer%2C+Ruth+M%3BVannucci%2C+Marina&rft.aulast=Kwon&rft.aufirst=Deukwoo&rft.date=2007-01-01&rft.volume=3&rft.issue=&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Cancer+Informatics&rft.issn=11769351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Mathematical models; Data processing; Bayesian analysis; Informatics; biomarkers; Stochasticity; Mass spectroscopy ER - TY - JOUR T1 - Analysis of Gene Expression Data Using BRB-Array Tools AN - 20663017; 9420477 AB - BRB-ArrayTools is an integrated software system for the comprehensive analysis of DNA microarray experiments. It was developed by professional biostatisticians experienced in the design and analysis of DNA microarray studies and incorporates methods developed by leading statistical laboratories. The software is designed for use by biomedical scientists who wish to have access to state-of-the-art statistical methods for the analysis of gene expression data and to receive training in the statistical analysis of high dimensional data. The software provides the most extensive set of tools available for predictive classifier development and complete cross-validation. It offers extensive links to genomic websites for gene annotation and analysis tools for pathway analysis. An archive of over 100 datasets of published microarray data with associated clinical data is provided and BRB-ArrayTools automatically imports data from the Gene Expression Omnibus public archive at the National Center for Biotechnology Information. JF - Cancer Informatics AU - Simon, Richard AU - Lam, Amy AU - Li, Ming-Chung AU - Ngan, Michael AU - Menenzes, Supriya AU - Zhao, Yingdong AD - Biometric Research Branch, National Cancer Institute, 9000 Rockville Pike, Bethesda MD Y1 - 2007 PY - 2007 DA - 2007 SP - 11 EP - 17 PB - Libertas Academica, PO Box 300-874 VL - 3 SN - 1176-9351, 1176-9351 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Bioinformatics KW - microarrays KW - gene expression KW - biostatistics KW - Gene expression KW - Computer programs KW - software KW - Data processing KW - Statistics KW - Informatics KW - Statistical analysis KW - genomics KW - DNA microarrays KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20663017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Informatics&rft.atitle=Analysis+of+Gene+Expression+Data+Using+BRB-Array+Tools&rft.au=Simon%2C+Richard%3BLam%2C+Amy%3BLi%2C+Ming-Chung%3BNgan%2C+Michael%3BMenenzes%2C+Supriya%3BZhao%2C+Yingdong&rft.aulast=Simon&rft.aufirst=Richard&rft.date=2007-01-01&rft.volume=3&rft.issue=&rft.spage=11&rft.isbn=&rft.btitle=&rft.title=Cancer+Informatics&rft.issn=11769351&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Computer programs; software; Statistics; Data processing; Informatics; Statistical analysis; genomics; DNA microarrays ER - TY - JOUR T1 - A perspective on microarrays: current applications, pitfalls, and potential uses AN - 20637740; 7275679 AB - With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly being used in laboratories around the world. In fact, fields as varied as: toxicology, evolutionary biology, drug development and production, disease characterization, diagnostics development, cellular physiology and stress responses, and forensics have benefiting from its use. However, for many researchers not familiar with microarrays, current articles and reviews often address neither the fundamental principles behind the technology nor the proper designing of experiments. Although, microarray technology is relatively simple, conceptually, its practice does require careful planning and detailed understanding of the limitations inherently present. Without these considerations, it can be exceedingly difficult to ascertain valuable information from microarray data. Therefore, this text aims to outline key features in microarray technology, paying particular attention to current applications as outlined in recent publications, experimental design, statistical methods, and potential uses. Furthermore, this review is not meant to be comprehensive, but rather substantive; highlighting important concepts and detailing steps necessary to conduct and interpret microarray experiments. Collectively, the information included in this text will highlight the versatility of microarray technology and provide a glimpse of what the future may hold. JF - Microbial Cell Factories AU - Jaluria, Pratik AU - Konstantopoulos, Konstantinos AU - Betenbaugh, Michael AU - Shiloach, Joseph AD - Department of Chemical and Biomolecular Engineering, Johns Hopkins University, 221 Maryland Hall, 3400 North Charles Street, Baltimore, MD 21218, USA, pratikj@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 6 SN - 1475-2859, 1475-2859 KW - Biotechnology Research Abstracts (through 1992) KW - Article No. 4 KW - Databases KW - Statistics KW - Forensic science KW - Stress KW - robotics KW - Drug development KW - genomics KW - Computer applications KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20637740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbial+Cell+Factories&rft.atitle=A+perspective+on+microarrays%3A+current+applications%2C+pitfalls%2C+and+potential+uses&rft.au=Jaluria%2C+Pratik%3BKonstantopoulos%2C+Konstantinos%3BBetenbaugh%2C+Michael%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2007-01-01&rft.volume=6&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Microbial+Cell+Factories&rft.issn=14752859&rft_id=info:doi/10.1186%2F1475-2859-6-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Statistics; Forensic science; Drug development; robotics; genomics; Databases; Stress; Computer applications DO - http://dx.doi.org/10.1186/1475-2859-6-4 ER - TY - JOUR T1 - Ginkgo Biloba Leave Extract: Biological, Medicinal, and Toxicological Effects AN - 20617427; 7965601 AB - Ginkgo biloba leave extract is among the most widely sold herbal dietary supplements in the United States. Its purported biological effects include: scavenging free radical; lowering oxidative stress; reducing neural damages, reducing platelets aggregation; anti-inflammation; anti-tumor activities; and anti-aging. Clinically, it has been prescribed to treat CNS disorders such as Alzheimer's disease and cognitive deficits. It exerts allergy and changes in bleeding time. While its mutagenicity or carcinogenic activity has not been reported, its components, quercetin, kaempferol and rutin have been shown to be genotoxic. There are no standards or guidelines regulating the constituent components of Ginkgo biloba leave extract nor are exposure limits imposed. Safety evaluation of Ginkgo biloba leave extract is being conducted by the U.S. National Toxicology Program. JF - Journal of Environmental Science and Health, Part C: Environmental Carcinogenesis and Ecotoxicology Reviews AU - Chan, P-C AU - Xia, Q AU - Fu, P P AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, chanp@niehs.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 211 EP - 244 VL - 25 IS - 1-4 SN - 1059-0501, 1059-0501 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Central nervous system KW - biological effects KW - Platelet aggregation KW - Alzheimer's disease KW - rutin KW - Allergies KW - Hypersensitivity KW - Carcinogenicity KW - guidelines KW - Oxidative stress KW - Toxicology KW - Mutagenicity KW - dietary supplements KW - Free radicals KW - Genotoxicity KW - Kaempferol KW - Antitumor agents KW - oxidative stress KW - Ginkgo biloba KW - Neurodegenerative diseases KW - USA KW - Cognitive ability KW - Reviews KW - Dietary supplements KW - Carcinogenesis KW - Bleeding KW - Quercetin KW - H 14000:Toxicology KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20617427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.atitle=Ginkgo+Biloba+Leave+Extract%3A+Biological%2C+Medicinal%2C+and+Toxicological+Effects&rft.au=Chan%2C+P-C%3BXia%2C+Q%3BFu%2C+P+P&rft.aulast=Chan&rft.aufirst=P-C&rft.date=2007-01-01&rft.volume=25&rft.issue=1-4&rft.spage=211&rft.isbn=&rft.btitle=&rft.title=Journal+of+Environmental+Science+and+Health%2C+Part+C%3A+Environmental+Carcinogenesis+and+Ecotoxicology+Reviews&rft.issn=10590501&rft_id=info:doi/10.1080%2F10590500701569414 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-02-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Central nervous system; Mutagenicity; Platelet aggregation; Free radicals; Genotoxicity; Alzheimer's disease; rutin; Kaempferol; Antitumor agents; Neurodegenerative diseases; Hypersensitivity; Cognitive ability; Oxidative stress; Dietary supplements; Carcinogenesis; Bleeding; Quercetin; dietary supplements; biological effects; guidelines; Carcinogenicity; Reviews; Allergies; oxidative stress; Toxicology; Ginkgo biloba; USA DO - http://dx.doi.org/10.1080/10590500701569414 ER - TY - JOUR T1 - Architecture of the Bacteriophage T4 Replication Complex Revealed with Nanoscale Biopointers AN - 20610489; 7252655 AB - Our previous electron microscopy of DNA replicated by the bacteriophage T4 proteins showed a single complex at the fork, thought to contain the leading and lagging strand proteins, as well as the protein-covered single-stranded DNA on the lagging strand folded into a compact structure. "Trombone" loops formed from nascent lagging strand fragments were present on a majority of the replicating molecules (Chastain, P., Makhov, A. M., Nossal, N. G., and Griffith, J. D. (2003) J. Biol. Chem. 278, 21276-21285). Here we probe the composition of this replication complex using nanoscale DNA biopointers to show the location of biotin-tagged replication proteins. We find that a large fraction of the molecules with a trombone loop had two pointers to polymerase, providing strong evidence that the leading and lagging strand polymerases are together in the replication complex. 6% of the molecules had two loops, and 31% of these had three pointers to biotin-tagged polymerase, suggesting that the two loops result from two fragments that are being extended simultaneously. Under fixation conditions that extend the lagging strand, occasional molecules show two nascent lagging strand fragments, each being elongated by a biotin-tagged polymerase. T4 41 helicase is present in the complex on a large fraction of actively replicating molecules but on a smaller fraction of molecules with a stalled polymerase. Unexpectedly, we found that 59 helicase-loading protein remains on the fork after loading the helicase and is present on molecules with extensive replication. JF - Journal of Biological Chemistry AU - Nossal, Nancy G AU - Makhov, Alexander M AU - Chastain, Paul DII AU - Jones, Charles E AU - Griffith, Jack D AD - Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-0830 and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7295 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1098 EP - 1108 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 2 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Bacteria KW - Replication KW - DNA probes KW - DNA KW - Single-stranded DNA KW - DNA helicase KW - Electron microscopy KW - N 14820:DNA Metabolism & Structure KW - V 22320:Replication KW - J 02430:Symbiosis, Antibiosis & Phages KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20610489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Architecture+of+the+Bacteriophage+T4+Replication+Complex+Revealed+with+Nanoscale+Biopointers&rft.au=Nossal%2C+Nancy+G%3BMakhov%2C+Alexander+M%3BChastain%2C+Paul+DII%3BJones%2C+Charles+E%3BGriffith%2C+Jack+D&rft.aulast=Nossal&rft.aufirst=Nancy&rft.date=2007-01-01&rft.volume=282&rft.issue=2&rft.spage=1098&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Replication; DNA probes; DNA; Single-stranded DNA; DNA helicase; Electron microscopy; Bacteria ER - TY - JOUR T1 - Detection of in Vitro Kinase Generated Protein Phosphorylation Sites Using gamma[ super(18)O sub(4)]-ATP and Mass Spectrometry AN - 20595004; 7986221 AB - A novel stable-isotope labeling approach for identification of phosphopeptides that utilizes adenosine triphosphate, in which four oxygen-16 atoms attached to the terminal phosphate group are substituted with oxygen-18 [gamma( super(18)O sub(4))-ATP], has been developed. The ability to use gamma( super(18)O sub(4))-ATP to monitor phosphorylation modification within various proteins was conducted by performing in vitro kinase reactions in the presence of a 1:1 mixture of gamma( super(18)O sub(4))-ATP and normal isotopic abundance ATP (ATP). After tryptic digestion, the peptides were analyzed using mass spectrometry (MS). Phosphorylated peptides are easily recognized within the MS spectrum owing to the presence of doublets separated by 6.01 Da; representing versions of the peptide modified by ATP and gamma( super(18)O sub(4))-ATP. Standard peptides phosphorylated using gamma( super(18)O sub(4))-ATP via in vitro kinase reactions showed no exchange loss of super(18)O with super(16)O. The identity of these doublets as phosphorylated peptides could be readily confirmed using tandem MS. The method described here provides the first direct stable-isotope labeling method to definitely detect phosphorylation sites within proteins. JF - Analytical Chemistry (Washington) AU - Zhou, Ming AU - Meng, Zhaojing AU - Jobson, Andrew G AU - Pommier, Yves AU - Veenstra, Timothy D AD - SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702-1201 Y1 - 2007 PY - 2007 DA - 2007 SP - 7603 EP - 7610 PB - American Chemical Society, Box 3337 Columbus OH 43210 USA, [mailto:service@acs.org] VL - 79 IS - 20 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phosphorylation KW - Phosphate KW - ATP KW - Mass spectroscopy KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20595004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Detection+of+in+Vitro+Kinase+Generated+Protein+Phosphorylation+Sites+Using+gamma%5B+super%2818%29O+sub%284%29%5D-ATP+and+Mass+Spectrometry&rft.au=Zhou%2C+Ming%3BMeng%2C+Zhaojing%3BJobson%2C+Andrew+G%3BPommier%2C+Yves%3BVeenstra%2C+Timothy+D&rft.aulast=Zhou&rft.aufirst=Ming&rft.date=2007-01-01&rft.volume=79&rft.issue=20&rft.spage=7603&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac071584r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Phosphate; Phosphorylation; ATP; Mass spectroscopy DO - http://dx.doi.org/10.1021/ac071584r ER - TY - JOUR T1 - Stability of Tubular Structures Based on beta2-Helical Proteins: Self- Assembled versus Polymerized Nanoconstructs and Wild-Type versus Mutated Sequences AN - 20563429; 8019652 AB - In this work we used atomistic molecular dynamics simulations to examine different aspects of tubular nanostructures constructed using protein building blocks with a beta2-helical conformation. Initially, we considered two different natural protein building blocks, which were extracted from the protein data base, to compare the relative stabilities of the nanotubes obtained made of self-assembled and covalently linked repeats. Results show nanotubes constructed by linking building blocks through covalent bonds are very stable suggesting that the basic principles of polymer physics are valid when the repeating units are made of large fragments of proteins. In contrast, the stability of self-assembled nanostructures strongly depends on the attractive nonbonding interactions associated to building blocks aligned in a complementary manner. On the other hand, we investigated the ability of a conformationally constrained synthetic amino acid to enhance the stability of both self-assembled and polymerized nanotubes when it is used to substitute natural residues. Specifically, we considered 1-aminocyclopentane- 1-caboxylic acid, which involves strong stereochemical constraints produced by the cyclopentane side chain. We found that the incorporation of this amino acid within the more flexible regions of the beta2-helical building blocks is an excellent strategy to enhance the stability of the nanotubes. Thus, when a single mutation is performed in the loop region of the beta2-helix, the bend architecture of the whole loop is stabilized since the conformational mobility is reduced not only at the mutated position but also at the adjacent positions. JF - Biomacromolecules AU - Zanuy, David AU - Rodriguez-Ropero, Francisco AU - Haspel, Nurit AU - Zheng, Jie AU - Nussinov, Ruth AU - Aleman, Carlos AD - Departament d'Enginyeria Quimica, E. T. S. d'Enginyeria Industrial de Barcelona, Universitat Politecnica de Catalunya, Diagonal 647, Barcelona E- 08028, Spain, Rice University, P.O. Box 1892, Houston, Texas 77251-1892, Basic Research Program, SAIC-Frederick Inc., Center for Cancer Research, Nanobiology Program, NCI-FCRDC, Frederick, Maryland 21702 Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 3135 EP - 3146 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 8 IS - 10 SN - 1525-7797, 1525-7797 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Amino acids KW - Mobility KW - nanotubes KW - Mutation KW - Cyclopentane KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20563429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=Stability+of+Tubular+Structures+Based+on+beta2-Helical+Proteins%3A+Self-+Assembled+versus+Polymerized+Nanoconstructs+and+Wild-Type+versus+Mutated+Sequences&rft.au=Zanuy%2C+David%3BRodriguez-Ropero%2C+Francisco%3BHaspel%2C+Nurit%3BZheng%2C+Jie%3BNussinov%2C+Ruth%3BAleman%2C+Carlos&rft.aulast=Zanuy&rft.aufirst=David&rft.date=2007-01-01&rft.volume=8&rft.issue=10&rft.spage=3135&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=15257797&rft_id=info:doi/10.1021%2Fbm700561tPII%3AS1525-7797%2870%2900561-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Databases; Amino acids; Mobility; nanotubes; Mutation; Cyclopentane DO - http://dx.doi.org/10.1021/bm700561tPII:S1525-7797(70)00561-5 ER - TY - JOUR T1 - Clinical Applications of Transcranial Doppler Sonography AN - 20558560; 7973523 AB - Transcranial Doppler sonography (TCD) is used to assess cerebral blood flow velocity in basal cerebral arteries and is a common tool for the diagnosis and follow-up of cerebrovascular disease. With more than 200 clinical studies using TCD published annually, indications for its use are expanding. The current article critically reviews standard and recent clinical applications for TCD including delayed vasospasm after subarachnoid hemorrhage, sickle cell disease, atherosclerosis of cranial vessels, ischemic stroke, brain trauma, brain death, carotid artery disease, cerebral venous thrombosis, intraoperative TCD monitoring, arteriovenous malformations, cardiac shunts and preeclampsia. JF - Reviews on Recent Clinical Trials AU - Schatlo, Bawarjan AU - Pluta, Ryszard M AD - Surgical Neurology Branch,NINDS, National Institutes of Health, 10 Center Drive, Room 5D37,Bethesda,MD 20892, USA. Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 49 EP - 57 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 2 IS - 1 SN - 1574-8871, 1574-8871 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Autoregulation KW - Cerebral blood flow KW - Cerebrovascular disease KW - Chemoregulation KW - Transcranial Dopplersonography KW - Stroke KW - subarachnoid hemorrhage KW - Brain injury KW - Vasoconstriction KW - Arteriosclerosis KW - Ischemia KW - Clinical trials KW - Thrombosis KW - Skull KW - Shunts KW - Reviews KW - Pre-eclampsia KW - Carotid artery KW - Traumatic brain injury KW - Sickle cell disease KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20558560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Reviews+on+Recent+Clinical+Trials&rft.atitle=Clinical+Applications+of+Transcranial+Doppler+Sonography&rft.au=Schatlo%2C+Bawarjan%3BPluta%2C+Ryszard+M&rft.aulast=Schatlo&rft.aufirst=Bawarjan&rft.date=2007-01-01&rft.volume=2&rft.issue=1&rft.spage=49&rft.isbn=&rft.btitle=&rft.title=Reviews+on+Recent+Clinical+Trials&rft.issn=15748871&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - subarachnoid hemorrhage; Brain injury; Stroke; Vasoconstriction; Ischemia; Arteriosclerosis; Clinical trials; Thrombosis; Skull; Reviews; Shunts; Pre-eclampsia; Carotid artery; Traumatic brain injury; Sickle cell disease; Cerebral blood flow ER - TY - JOUR T1 - The Use of Compressor Cycle Patterns: The Ability to Predict Freezer Failure AN - 20556387; 9264173 AB - Biorepositories are tasked with the care and storage of priceless collections of biological specimens. Critical to the success of biorepository operations is the safe, secure, viable storage of the specimens entrusted to its care. The primary means by which this is accomplished is to ensure proper function of ultralow freezers. For a large biorepository this involves the tracking and monitoring of hundreds of freezers. Biorepository procedures typically require recording of the temperature of each freezer on a daily basis. At the Central Repository of the National Cancer Institute in Frederick, Maryland, temperature monitoring has been taken one step further. New procedures utilize the in-house 24-h temperature monitoring system to produce daily printouts of the fluctuation of temperature with time. These graphs are reviewed, and based upon an understanding of freezer compressor cycles are used to identify potential problems with freezer function. These new procedures, which can be used to predict failure, have identified specific types of temperature traces that are indicative of a failure rate 2.9 times greater than normal. JF - Cell Preservation Technology AU - Groover, K AU - Drew, K AU - Franke, J AD - NCI Frederick Central Repository Services Fisher BioServices 4600 Wedgewood Boulevard, Suite H Frederick, MD 21703, USA, kathleen.groover@thermofisher.com Y1 - 2007 PY - 2007 DA - 2007 SP - 225 EP - 228 VL - 5 IS - 4 SN - 1538-344X, 1538-344X KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Reviews KW - Temperature requirements KW - Preservation KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20556387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Preservation+Technology&rft.atitle=The+Use+of+Compressor+Cycle+Patterns%3A+The+Ability+to+Predict+Freezer+Failure&rft.au=Groover%2C+K%3BDrew%2C+K%3BFranke%2C+J&rft.aulast=Groover&rft.aufirst=K&rft.date=2007-01-01&rft.volume=5&rft.issue=4&rft.spage=225&rft.isbn=&rft.btitle=&rft.title=Cell+Preservation+Technology&rft.issn=1538344X&rft_id=info:doi/10.1089%2Fcpt.2007.0510 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Temperature effects; Reviews; Temperature requirements; Preservation DO - http://dx.doi.org/10.1089/cpt.2007.0510 ER - TY - JOUR T1 - Modifications to a Standard Buccal Collection Protocol: Effects on Human DNA Yield AN - 20555448; 9264172 AB - A standard mouthwash protocol (a single 10-mL swish of mouthwash for 45 sec) was modified in an attempt to increase the amount of human buccal cell DNA per collection and to reduce the percentage of low yielding human DNA collections (<4 mu g). A group of 22 healthy individuals donated a buccal sample each week for several weeks according to the standard protocol without or with one of the following modifications: (1) decreasing the volume of mouthwash, (2) having participants externally rub or not rub their cheeks before donating a specimen, (3) donating two consecutive specimens at each collection, (4) substituting saline for mouthwash, and (5) having individuals expectorate into mouthwash. There was no significant difference in the amount of human DNA collected when 10 mL or 5 mL of mouthwash was used. Externally rubbing cheeks before donating did not significantly alter the amount of human DNA collected, regardless of whether it was one or two donations. Addition of a second donation resulted in 24% to 50% more human DNA than from only a single donation, regardless of whether 5 mL or 10 mL of mouthwash was used, with or without cheek rubbing. With two donations, the percentage of low-yielding human DNA samples was reduced up to 31%. Substituting saline for mouthwash resulted in a significantly lower amount of human buccal DNA collected, regardless of cheek rubbing, and a higher number of low-yielding samples. Expectorating directly into mouthwash while externally rubbing cheeks performed the best (17.70 mu g human DNA), followed by swishing 2-10 mL of mouthwash before expectorating (12.26 mu g). Both protocols had 95% of their samples yielding at least 4 mu g of human DNA without increasing cost; however, when selecting a collection protocol the age and health status of the cohort needs to be considered. JF - Cell Preservation Technology AU - Shao, W AU - Garcia-Closas, M AU - Alguacil, J AU - Rothman, N AU - Schatzkin, A AU - Vaught, J AU - Sigurdson, A AU - Cosentino, M AD - 1066 Boyles Street Room 100, P.O. Box B NCI-Frederick Frederick MD 21702, USA, mcosentino@ncifcrf.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 216 EP - 224 VL - 5 IS - 4 SN - 1538-344X, 1538-344X KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Cheek KW - Age KW - Mouthwashes KW - DNA KW - Preservation KW - W 30940:Products KW - N 14845:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20555448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Preservation+Technology&rft.atitle=Modifications+to+a+Standard+Buccal+Collection+Protocol%3A+Effects+on+Human+DNA+Yield&rft.au=Shao%2C+W%3BGarcia-Closas%2C+M%3BAlguacil%2C+J%3BRothman%2C+N%3BSchatzkin%2C+A%3BVaught%2C+J%3BSigurdson%2C+A%3BCosentino%2C+M&rft.aulast=Shao&rft.aufirst=W&rft.date=2007-01-01&rft.volume=5&rft.issue=4&rft.spage=216&rft.isbn=&rft.btitle=&rft.title=Cell+Preservation+Technology&rft.issn=1538344X&rft_id=info:doi/10.1089%2Fcpt.2007.0512 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cheek; Age; Mouthwashes; DNA; Preservation DO - http://dx.doi.org/10.1089/cpt.2007.0512 ER - TY - JOUR T1 - Biotechnology and the Treatment of Addictive Disorders: New Opportunities AN - 20552486; 7920732 AB - Addiction is a chronic relapsing illness with onset typically occurring in the early teenage years, followed by cycles of drug use and abstinence. The disease is mitigated by complex interactions between genes and environment. Viewed as such, the treatment of addiction could span the whole lifetime of the patient and, ideally, should be tailored to the illness cycle. The search for effective treatments has intensified recently due to our better understanding of the underlying neurobiologic mechanisms contributing to drug use and relapse. The three main types of treatment are behavioral, pharmacologic and, more recently, immunologic therapies. Vaccines and monoclonal antibodies are being developed mainly for stimulant use disorders and nicotine addiction. In addition, new molecular targets identified by preclinical research have shown promise and are awaiting proof- of-concept studies in humans. The main focus of this review is on the development of immunotherapy for stimulants and nicotine addiction as a model highlighting the current status of the science and potential emerging discoveries and development. JF - BioDrugs AU - Elkashef, Ahmed AU - Biswas, Jamie AU - Acri, Jane B AU - Vocci, Frank AD - Division of Pharmacotherapies and Medical Consequences of Drug Abuse (DPMC), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Bethesda, Maryland, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 259 EP - 267 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 21 IS - 4 SN - 1173-8804, 1173-8804 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cocaine abuse vaccine TA CD KW - Dependence KW - Drug withdrawal therapies KW - Immunological desensitisation KW - Immunostimulants KW - Nicotine abuse vaccine KW - Research and development KW - Substance abuse KW - Vaccines KW - Nicotine KW - Monoclonal antibodies KW - Immunotherapy KW - Reviews KW - Stimulants KW - Addiction KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20552486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs&rft.atitle=Biotechnology+and+the+Treatment+of+Addictive+Disorders%3A+New+Opportunities&rft.au=Elkashef%2C+Ahmed%3BBiswas%2C+Jamie%3BAcri%2C+Jane+B%3BVocci%2C+Frank&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2007-01-01&rft.volume=21&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=BioDrugs&rft.issn=11738804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Monoclonal antibodies; Nicotine; Reviews; Immunotherapy; Stimulants; Vaccines; Addiction ER - TY - JOUR T1 - Synthesis of Cetuximab-Immunoliposomes via a Cholesterol-Based Membrane Anchor for Targeting of EGFR AN - 20526693; 7599370 AB - The objective of the present study was to construct epidermal growth factor receptor (EGFR) targeting cetuximab-immunoliposomes (ILs) for targeted delivery of boron compounds to EGFR(+) glioma cells for neutron capture therapy. The ILs were synthesized by using a novel cholesterol-based membrane anchor, maleimido-PEG-cholesterol (Mal-PEG-Chol), to incorporate cetuximab into liposomes by either surface conjugation or a post-insertion method. For post-insertion, the transfer efficiency of MAb conjugates from micelles to liposome was examined at varying temperatures, mPEG sub(2000)-DSPE ratios, and micelle-to-liposome lipid ratios. Following this, the cetuximab-ILs were evaluated for targeted delivery of the encapsulated boron anion, dodecahydro-closo-dodecaborate (2-) (B sub(12)H super(2) sub(1) super(-) sub(2)), to human EGFR gene transfected F98 sub(EGFR) glioma cells as potential delivery agents for boron neutron capture therapy (BNCT). In addition, cellular uptake of cetuximab-ILs, encapsulating a fluorescence dye, was analyzed by confocal fluorescence microscopy and flow cytometry, and boron content was quantified by ICP-MS. Much greater ( similar to 8-fold) cellular uptake of boron was obtained using cetuximab-ILs in EGFR(+) F98 sub(EGFR) compared with nontargeted human IgG-ILs. On the basis of these observations, we have concluded that cholesterol can serve as an effective anchor for MAb in liposomes, and cetuximab-ILs are potentially useful delivery vehicles for BNCT of gliomas. JF - Bioconjugate Chemistry AU - Pan, X AU - Wu, G AU - Yang, W AU - Barth, R F AU - Tjarks, W AU - Lee, R J AD - Division of Pharmaceutics, College of Pharmacy, NSF Nanoscale Science and Engineering Center (NSEC), Center for Affordable Nanoengineering of Polymeric Biomedical Devices (CANPBD), Department of Pathology, Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, and NCI Comprehensive Cancer Center (CCC), The Ohio State University, Columbus, Ohio, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 101 EP - 108 VL - 18 IS - 1 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Temperature effects KW - Anions KW - Monoclonal antibodies KW - Lipids KW - Epidermal growth factor receptors KW - Cholesterol KW - Liposomes KW - Boron KW - Brain tumors KW - Flow cytometry KW - Neutrons KW - Micelles KW - Glioma cells KW - Glioma KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20526693?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=Synthesis+of+Cetuximab-Immunoliposomes+via+a+Cholesterol-Based+Membrane+Anchor+for+Targeting+of+EGFR&rft.au=Pan%2C+X%3BWu%2C+G%3BYang%2C+W%3BBarth%2C+R+F%3BTjarks%2C+W%3BLee%2C+R+J&rft.aulast=Pan&rft.aufirst=X&rft.date=2007-01-01&rft.volume=18&rft.issue=1&rft.spage=101&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc060174r LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Anions; Monoclonal antibodies; Lipids; Epidermal growth factor receptors; Cholesterol; Boron; Liposomes; Neutrons; Flow cytometry; Brain tumors; Micelles; Glioma cells; Glioma DO - http://dx.doi.org/10.1021/bc060174r ER - TY - JOUR T1 - Prevalence and Variation of Physical Restraint Use in Acute Care Settings in the US AN - 20464027; 9148098 AB - Purpose: To describe physical restraint (PR) rates and contexts in U.S. hospitals.Design: This 2003-2005 descriptive study was done to measure PR prevalence and contexts (census, gender, age, ventilation status, PR type, and rationale) at 40 randomly selected acute care hospitals in six U.S. metropolitan areas. All units except psychiatric, emergency, operative, obstetric, and long-term care were included.Methods: On 18 randomly selected days between 0500 and 0700 (5:00 am and 7:00 am), data collectors determined PR use and contexts via observation and nurse report.Findings: PR prevalence was 50 per 1,000 patient days (based on 155,412 patient days). Preventing disruption of therapy was the chief reason cited. PR rates varied by unit type, with adult ICU rates the highest obtained. Intra- and interinstitutional variation was as high as 10-fold. Ventilator use was strongly associated with PR use. Elderly patients were over-represented among the physically restrained on some units (e.g., medical) but on many unit types (including most ICUs) their PR use was consistent with those of other adults.Conclusions: Wide rate variation indicates the need to examine administratively mediated variables and the promotion of unit-based improvement efforts. Anesthetic and sedation practices have contributed to high variation in ICU PR rates. Determining the types of units to target to achieve improvements in care of older adults requires study of PR sequelae rate by unit type.Journal of Nursing Scholarship, 2007; 39:1, 30-37. [copy2007 Sigma Theta Tau International. JF - Journal of Nursing Scholarship AU - Minnick, Ann F AU - Mion, Lorraine C AU - Johnson, Mary E AU - Catrambone, Cathy AU - Leipzig, Rosanne AD - 1Ann F. Minnick, RN, PhD, FAAN, Gamma Phi, Chenault Professor of Nursing, School of Nursing, Vanderbilt University, Nashville, TN; Lorraine C. Mion, RN, PhD, FAAN, Alpha Mu, Director, Nursing Research, MetroHealth Care Medical Center, Cleveland, OH; Mary E. Johnson, RN, PhD, Associate Professor, College of Nursing, Rush University, Chicago, IL; Cathy Catrambone, RN, DNSc, Instructor, College of Nursing, Rush University, Chicago, IL; Rosanne Leipzig, MD, Professor, Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, NY. The project was supported by Grant 1R01AG19715-01 from the National Institute on Aging. Contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the National Institute on Aging, NIH. Correspondence to Dr. Minnick, Vanderbilt University, Godchaux Hall, Room 424, 21st Avenue South, Nashville, TN 37240, Ann.Minnick@vanderbilt.edu Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 30 EP - 37 PB - Blackwell Publishing Ltd., 9600 Garsington Road VL - 39 IS - 1 SN - 1527-6546, 1527-6546 KW - Health & Safety Science Abstracts KW - physical restraints KW - acute care hospitals KW - therapy disruption KW - patient safety KW - census KW - USA KW - Age KW - Ventilation KW - Gender KW - elderly KW - metropolitan areas KW - nursing KW - Medical personnel KW - Hospitals KW - H 13000:Medical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20464027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nursing+Scholarship&rft.atitle=Prevalence+and+Variation+of+Physical+Restraint+Use+in+Acute+Care+Settings+in+the+US&rft.au=Minnick%2C+Ann+F%3BMion%2C+Lorraine+C%3BJohnson%2C+Mary+E%3BCatrambone%2C+Cathy%3BLeipzig%2C+Rosanne&rft.aulast=Minnick&rft.aufirst=Ann&rft.date=2007-01-01&rft.volume=39&rft.issue=1&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nursing+Scholarship&rft.issn=15276546&rft_id=info:doi/10.1111%2Fj.1547-5069.2007.00140.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - census; Age; Ventilation; Gender; elderly; nursing; metropolitan areas; Medical personnel; Hospitals; USA DO - http://dx.doi.org/10.1111/j.1547-5069.2007.00140.x ER - TY - JOUR T1 - Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view AN - 20369777; 7730434 AB - Only a handful of radiolabeled antibodies (Abs) have gained US Food and Drag Administration (FDA) approval for use in clinical oncology, including four immunodiagnostic agents and two targeted radioimmunotherapeutic agents. Despite the advent of nonimmunogenic Abs and the availability of a diverse library of radionuclides, progress beyond early Phase II radioimmunotherapy (RIT) studies in solid tumors has been marginal. Furthermore, [ super(18)F]fluorodeoxyglucose continues to dominate the molecular imaging domain, underscored by a decade-long absence of any newly approved Ab-based imaging agent (none since 1996). Why has the development of clinically successful Abs for RIT been limited to lymphoma? What obstacles must be overcome to allow the FDA approval of immuno-positron emission tomography (immuno-PET) imaging agents? How can we address the unique challenges that have thus far prevented the introduction of Ab-based imaging agents and therapeutics for solid tumors? Many poor decisions have been made regarding radiolabeled Abs, but useful insight can be gained from these mistakes. The following review addresses the physical, chemical, biological, clinical, regulatory and financial limitations that impede the progress of this increasingly important class of drugs. JF - Nuclear Medicine and Biology AU - Boswell, CA AU - Brechbiel, M W AD - Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA, martmwb@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 757 EP - 778 VL - 34 IS - 7 SN - 0969-8051, 0969-8051 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Solid tumors KW - Food KW - Oncology KW - imaging KW - Antibodies KW - Reviews KW - Radioisotopes KW - Tomography KW - Drugs KW - Lymphoma KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20369777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nuclear+Medicine+and+Biology&rft.atitle=Development+of+radioimmunotherapeutic+and+diagnostic+antibodies%3A+an+inside-out+view&rft.au=Boswell%2C+CA%3BBrechbiel%2C+M+W&rft.aulast=Boswell&rft.aufirst=CA&rft.date=2007-01-01&rft.volume=34&rft.issue=7&rft.spage=757&rft.isbn=&rft.btitle=&rft.title=Nuclear+Medicine+and+Biology&rft.issn=09698051&rft_id=info:doi/10.1016%2Fj.nucmedbio.2007.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; Antibodies; Solid tumors; Reviews; Tomography; Lymphoma; Food; Drugs; Oncology; Radioisotopes DO - http://dx.doi.org/10.1016/j.nucmedbio.2007.04.001 ER - TY - JOUR T1 - Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study AN - 20365725; 9029212 AB - Background Echocardiographic left ventricular (LV) measurements, exercise responses to standardized treadmill test (ETT) and brachial artery (BA) vascular function are heritable traits that are associated with cardiovascular disease risk. We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study. Methods We estimated multivariable-adjusted residuals for quantitative echocardiography, ETT and BA function traits. Echocardiography residuals were averaged across 4 examinations and included LV mass, diastolic and systolic dimensions, wall thickness, fractional shortening, left atrial and aortic root size. ETT measures (single exam) included systolic blood pressure and heart rate responses during exercise stage 2, and at 3 minutes post-exercise. BA measures (single exam) included vessel diameter, flow-mediated dilation (FMD), and baseline and hyperemic flow responses. Generalized estimating equations (GEE), family-based association tests (FBAT) and variance-components linkage were used to relate multivariable-adjusted trait residuals to 70,987 SNPs (Human 100K GeneChip, Affymetrix) restricted to autosomal SNPs with minor allele frequency greater than or equal to 0.10, genotype call rate greater than or equal to 0.80, and Hardy-Weinberg equilibrium p greater than or equal to 0.001. Results We summarize results from 17 traits in up to 1238 related middle-aged to elderly men and women. Results of all association and linkage analyses are web-posted at . We confirmed modest-to-strong heritabilities (estimates 0.30-0.52) for several Echo, ETT and BA function traits. Overall, p & 10 super(-5 )in either GEE or FBAT models were observed for 21 SNPs (nine for echocardiography, eleven for ETT and one for BA function). The top SNPs associated were (GEE results): LV diastolic dimension, rs1379659 (SLIT2, p = 1.17*10 super(-7)); LV systolic dimension, rs10504543 (KCNB2, p = 5.18*10 super(-6)); LV mass, rs10498091 (p = 5.68*10 super(-6)); Left atrial size, rs1935881 (FAM5C, p = 6.56*10 super(-6)); exercise heart rate, rs6847149 (NOLA1, p = 2.74*10 super(-6)); exercise systolic blood pressure, rs2553268 (WRN, p = 6.3*10 super(-6)); BA baseline flow, rs3814219 (OBFC1, 9.48*10 super(-7)), and FMD, rs4148686 (CFTR, p = 1.13*10 super(-5)). Several SNPs are reasonable biological candidates, with some being related to multiple traits suggesting pleiotropy. The peak LOD score was for LV mass (4.38; chromosome 5); the 1.5 LOD support interval included NRG2. Conclusion In hypothesis-generating GWAS of echocardiography, ETT and BA vascular function in a moderate-sized community-based sample, we identified several SNPs that are candidates for replication attempts and we provide a web-based GWAS resource for the research community. JF - BMC Medical Genetics AU - Vasan, Ramachandran S AU - Larson, Martin G AU - Aragam, Jayashri AU - Wang, Thomas J AU - Mitchell, Gary F AU - Kathiresan, Sekar AU - Newton-Cheh, Christopher AU - Vita, Joseph A AU - Keyes, Michelle J AU - O'Donnell, Christopher J AU - Levy, Daniel AU - Benjamin, Emelia J AD - The National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA, USA, vasan@bu.edu Y1 - 2007 PY - 2007 DA - 2007 SP - S2 PB - BioMed Central Ltd., Middlesex House VL - 8 IS - Suppl 1 SN - 1471-2350, 1471-2350 KW - Genetics Abstracts; Physical Education Index KW - Arteries KW - Heart rate KW - Genotypes KW - chromosome 5 KW - Blood pressure KW - Models KW - Ventricle KW - Geriatrics KW - Diseases KW - Treadmill ergometry KW - Vascular system KW - Circulatory system KW - Heart KW - Mathematical models KW - Replication KW - Aorta KW - Echocardiography KW - Exercise KW - Physical training KW - pleiotropy KW - Linkage analysis KW - Vocalization behavior KW - Single-nucleotide polymorphism KW - Reviews KW - Analysis KW - Gene frequency KW - Cardiovascular diseases KW - Heritability KW - G 07880:Human Genetics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20365725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Genetics&rft.atitle=Genome-wide+association+of+echocardiographic+dimensions%2C+brachial+artery+endothelial+function+and+treadmill+exercise+responses+in+the+Framingham+Heart+Study&rft.au=Vasan%2C+Ramachandran+S%3BLarson%2C+Martin+G%3BAragam%2C+Jayashri%3BWang%2C+Thomas+J%3BMitchell%2C+Gary+F%3BKathiresan%2C+Sekar%3BNewton-Cheh%2C+Christopher%3BVita%2C+Joseph+A%3BKeyes%2C+Michelle+J%3BO%27Donnell%2C+Christopher+J%3BLevy%2C+Daniel%3BBenjamin%2C+Emelia+J&rft.aulast=Vasan&rft.aufirst=Ramachandran&rft.date=2007-01-01&rft.volume=8&rft.issue=Suppl+1&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Genetics&rft.issn=14712350&rft_id=info:doi/10.1186%2F1471-2350-8-S1-S2 LA - English DB - Physical Education Index N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Analysis; Heart rate; Echocardiography; Diseases; Exercise; Blood pressure; Treadmill ergometry; Circulatory system; Mathematical models; Replication; Arteries; Aorta; Genotypes; chromosome 5; Models; Physical training; pleiotropy; Ventricle; Linkage analysis; Vocalization behavior; Single-nucleotide polymorphism; Reviews; Geriatrics; Gene frequency; Cardiovascular diseases; Heritability; Vascular system DO - http://dx.doi.org/10.1186/1471-2350-8-S1-S2 ER - TY - JOUR T1 - Trinucleotide cassettes increase diversity of T7 phage-displayed peptide library AN - 20357820; 9030071 AB - Background Amino acid sequence diversity is introduced into a phage-displayed peptide library by randomizing library oligonucleotide DNA. We recently evaluated the diversity of peptide libraries displayed on T7 lytic phage and M13 filamentous phage and showed that T7 phage can display a more diverse amino acid sequence repertoire due to differing processes of viral morphogenesis. Methods In this study, we evaluated and compared the diversity of a 12-mer T7 phage-displayed peptide library randomized using codon-corrected trinucleotide cassettes with a T7 and an M13 12-mer phage-displayed peptide library constructed using the degenerate codon randomization method. Results We herein demonstrate that the combination of trinucleotide cassette amino acid codon randomization and T7 phage display construction methods resulted in a significant enhancement to the functional diversity of a 12-mer peptide library. This novel library exhibited superior amino acid uniformity and order-of-magnitude increases in amino acid sequence diversity as compared to degenerate codon randomized peptide libraries. Comparative analyses of the biophysical characteristics of the 12-mer peptide libraries revealed the trinucleotide cassette-randomized library to be a unique resource. Conclusion The combination of T7 phage display and trinucleotide cassette randomization resulted in a novel resource for the potential isolation of binding peptides for new and previously studied molecular targets. JF - BMC Biotechnology AU - Krumpe, Lauren RH AU - Schumacher, Kathryn M AU - McMahon, James B AU - Makowski, Lee AU - Mori, Toshiyuki AD - Molecular Targets Development Program, Center for Cancer Research, NCI-Frederick, Frederick, Maryland, 21702, USA, lhaugh@ncifcrf.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 65 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Nucleotide sequence KW - Phage display KW - Morphogenesis KW - Codons KW - Peptide libraries KW - Oligonucleotides KW - Amino acid sequence KW - N 14815:Nucleotide Sequence KW - W 30940:Products KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20357820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biotechnology&rft.atitle=Trinucleotide+cassettes+increase+diversity+of+T7+phage-displayed+peptide+library&rft.au=Krumpe%2C+Lauren+RH%3BSchumacher%2C+Kathryn+M%3BMcMahon%2C+James+B%3BMakowski%2C+Lee%3BMori%2C+Toshiyuki&rft.aulast=Krumpe&rft.aufirst=Lauren&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=65&rft.isbn=&rft.btitle=&rft.title=BMC+Biotechnology&rft.issn=1472-6750&rft_id=info:doi/10.1186%2F1472-6750-7-65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Nucleotide sequence; Morphogenesis; Phage display; Codons; Peptide libraries; Oligonucleotides; Amino acid sequence DO - http://dx.doi.org/10.1186/1472-6750-7-65 ER - TY - JOUR T1 - Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project AN - 20356713; 9029211 AB - Background Obesity is related to multiple cardiovascular disease (CVD) risk factors as well as CVD and has a strong familial component. We tested for association between SNPs on the Affymetrix 100K SNP GeneChip and measures of adiposity in the Framingham Heart Study. Methods A total of 1341 Framingham Heart Study participants in 310 families genotyped with the Affymetrix 100K SNP GeneChip had adiposity traits measured over 30 years of follow up. Body mass index (BMI), waist circumference (WC), weight change, height, and radiographic measures of adiposity (subcutaneous adipose tissue, visceral adipose tissue, waist circumference, sagittal height) were measured at multiple examination cycles. Multivariable-adjusted residuals, adjusting for age, age-squared, sex, smoking, and menopausal status, were evaluated in association with the genotype data using additive Generalized Estimating Equations (GEE) and Family Based Association Test (FBAT) models. We prioritized mean BMI over offspring examinations (1-7) and cohort examinations (10, 16, 18, 20, 22, 24, 26) and mean WC over offspring examinations (4-7) for presentation. We evaluated associations with 70,987 SNPs on autosomes with minor allele frequencies of at least 0.10, Hardy-Weinberg equilibrium p greater than or equal to 0.001, and call rates of at least 80%. Results The top SNPs to be associated with mean BMI and mean WC by GEE were rs110683 (p-value 1.22*10 super(-7)) and rs4471028 (p-values 1.96*10 super(-7)). Please see for the complete set of results. We were able to validate SNPs in known genes that have been related to BMI or other adiposity traits, including the ESR1 Xba1 SNP, PPARG, and ADIPOQ. Conclusion Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC. JF - BMC Medical Genetics AU - Fox, Caroline S AU - Heard-Costa, Nancy AU - Cupples, L Adrienne AU - Dupuis, Josee AU - Vasan, Ramachandran S AU - Atwood, Larry D AD - The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA, foxca@nhlbi.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - S18 PB - BioMed Central Ltd., Middlesex House VL - 8 IS - Suppl 1 SN - 1471-2350, 1471-2350 KW - Genetics Abstracts; Physical Education Index KW - Measurement KW - Age KW - Peroxisome proliferator-activated receptors KW - Body mass KW - Genotypes KW - Models KW - Evaluation KW - Smoking KW - Genetics KW - ESR1 protein KW - Risk factors KW - Heart KW - Obesity KW - Mathematical models KW - Data processing KW - Replication KW - Height KW - Vocalization behavior KW - Waist KW - Single-nucleotide polymorphism KW - Adipose tissue KW - Family KW - Fats KW - Gene frequency KW - Progeny KW - Cardiovascular diseases KW - Body mass index KW - G 07880:Human Genetics KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20356713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Genetics&rft.atitle=Genome-wide+association+to+body+mass+index+and+waist+circumference%3A+the+Framingham+Heart+Study+100K+project&rft.au=Fox%2C+Caroline+S%3BHeard-Costa%2C+Nancy%3BCupples%2C+L+Adrienne%3BDupuis%2C+Josee%3BVasan%2C+Ramachandran+S%3BAtwood%2C+Larry+D&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2007-01-01&rft.volume=8&rft.issue=Suppl+1&rft.spage=S18&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Genetics&rft.issn=14712350&rft_id=info:doi/10.1186%2F1471-2350-8-S1-S18 LA - English DB - Physical Education Index N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Heart; Evaluation; Genetics; Measurement; Waist; Body mass; Fats; Family; Height; Obesity; Age; Data processing; Mathematical models; Peroxisome proliferator-activated receptors; Replication; Genotypes; Models; Smoking; ESR1 protein; Vocalization behavior; Single-nucleotide polymorphism; Risk factors; Adipose tissue; Progeny; Gene frequency; Cardiovascular diseases; Body mass index DO - http://dx.doi.org/10.1186/1471-2350-8-S1-S18 ER - TY - JOUR T1 - Enhancement of cell proliferation in various mammalian cell lines by gene insertion of a cyclin-dependent kinase homolog AN - 20354172; 9030077 AB - Background Genomics tools, particularly DNA microarrays, have found application in a number of areas including gene discovery and disease characterization. Despite the vast utility of these tools, little work has been done to explore the basis of distinct cellular properties, especially those important to biotechnology such as growth. And so, with the intent of engineering cell lines by manipulating the expression of these genes, anchorage-independent and anchorage-dependent HeLa cells, displaying markedly different growth characteristics, were analyzed using DNA microarrays. Results Two genes, cyclin-dependent kinase like 3 (cdkl3) and cytochrome c oxidase subunit (cox15), were up-regulated in the faster growing, anchorage-independent (suspension) HeLa cells relative to the slower growing, anchorage-dependent (attached) HeLa cells. Enhanced expression of either gene in the attached HeLa cells resulted in elevated cell proliferation, though insertion of cdkl3 had a greater impact than that of cox15. Moreover, flow cytometric analysis indicated that cells with an insert of cdkl3 were able to transition from the G0/G1 phases to the S phase faster than control cells. In turn, expression of cox15 was seen to increase the maximum viable cell numbers achieved relative to the control, and to a greater extent than cdkl3. Quantitatively similar results were obtained with two Human Embryonic Kidney-293 (HEK-293) cell lines and a Chinese Hamster Ovary (CHO) cell line. Additionally, HEK-293 cells secreting adipocyte complement-related protein of 30 kDa (acrp30) exhibited a slight increase in specific protein production and higher total protein production in response to the insertion of either cdkl3 or cox15. Conclusion These results are consistent with previous studies on the functionalities of cdkl3 and cox15. For instance, the effect of cdkl3 on cell growth is consistent with its homology to the cdk3 gene which is involved in G1 to S phase transition. Likewise, the increase in cell viability due to cox15 expression is consistent with its role in oxidative phosphorylation as an assembly factor for cytochrome c oxidase and its involvement removing apoptosis-inducing oxygen radicals. Collectively, the present study illustrates the potential of using microarray technology to identify genes influential to specific cellular processes with the possibility of engineering cell lines as desired to meet production needs. JF - BMC Biotechnology AU - Jaluria, Pratik AU - Betenbaugh, Michael AU - Konstantopoulos, Konstantinos AU - Shiloach, Joseph AD - Department of Chemical and Biomolecular Engineering, Johns Hopkins University. 221 Maryland Hall, 3400 North Charles Street, Baltimore, MD 21218 USA, pratikj@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 71 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell number KW - Oxidative phosphorylation KW - Cytochrome-c oxidase KW - DNA microarrays KW - Flow cytometry KW - Reactive oxygen species KW - Mammalian cells KW - Homology KW - Cyclin-dependent kinase KW - S phase KW - Adipocytes KW - G1 phase KW - Embryos KW - genomics KW - Cell proliferation KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20354172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Biotechnology&rft.atitle=Enhancement+of+cell+proliferation+in+various+mammalian+cell+lines+by+gene+insertion+of+a+cyclin-dependent+kinase+homolog&rft.au=Jaluria%2C+Pratik%3BBetenbaugh%2C+Michael%3BKonstantopoulos%2C+Konstantinos%3BShiloach%2C+Joseph&rft.aulast=Jaluria&rft.aufirst=Pratik&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=BMC+Biotechnology&rft.issn=1472-6750&rft_id=info:doi/10.1186%2F1472-6750-7-71 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cell number; Oxidative phosphorylation; Cytochrome-c oxidase; DNA microarrays; Flow cytometry; Cyclin-dependent kinase; Homology; Mammalian cells; Reactive oxygen species; S phase; Adipocytes; G1 phase; Embryos; genomics; Cell proliferation DO - http://dx.doi.org/10.1186/1472-6750-7-71 ER - TY - JOUR T1 - Paradoxes in carcinogenesis: New opportunities for research directions AN - 20352552; 9029380 AB - Background The prevailing paradigm in cancer research is the somatic mutation theory that posits that cancer begins with a single mutation in a somatic cell followed by successive mutations. Much cancer research involves refining the somatic mutation theory with an ever increasing catalog of genetic changes. The problem is that such research may miss paradoxical aspects of carcinogenesis for which there is no likely explanation under the somatic mutation theory. These paradoxical aspects offer opportunities for new research directions that should not be ignored. Discussion Various paradoxes related to the somatic mutation theory of carcinogenesis are discussed: (1) the presence of large numbers of spatially distinct precancerous lesions at the onset of promotion, (2) the large number of genetic instabilities found in hyperplastic polyps not considered cancer, (3) spontaneous regression, (4) higher incidence of cancer in patients with xeroderma pigmentosa but not in patients with other comparable defects in DNA repair, (5) lower incidence of many cancers except leukemia and testicular cancer in patients with Down's syndrome, (6) cancer developing after normal tissue is transplanted to other parts of the body or next to stroma previously exposed to carcinogens, (7) the lack of tumors when epithelial cells exposed to a carcinogen were transplanted next to normal stroma, (8) the development of cancers when Millipore filters of various pore sizes were was inserted under the skin of rats, but only if the holes were sufficiently small. For the latter paradox, a microarray experiment is proposed to try to better understand the phenomena. Summary The famous physicist Niels Bohr said "How wonderful that we have met with a paradox. Now we have some hope of making progress." The same viewpoint should apply to cancer research. It is easy to ignore this piece of wisdom about the means to advance knowledge, but we do so at our peril. JF - BMC Cancer AU - Baker, Stuart G AU - Kramer, Barnett S AD - Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA, sb16i@nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 151 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Toxicology Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Testes KW - Stroma KW - Epithelial cells KW - Skin KW - Catalogs KW - Polyps KW - Tumors KW - Carcinogens KW - Somatic cells KW - DNA repair KW - Cancer KW - Filters KW - Leukemia KW - Pores KW - Carcinogenesis KW - Down's syndrome KW - Mutation KW - X 24310:Pharmaceuticals KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20352552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Cancer&rft.atitle=Paradoxes+in+carcinogenesis%3A+New+opportunities+for+research+directions&rft.au=Baker%2C+Stuart+G%3BKramer%2C+Barnett+S&rft.aulast=Baker&rft.aufirst=Stuart&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=BMC+Cancer&rft.issn=1471-2407&rft_id=info:doi/10.1186%2F1471-2407-7-151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stroma; Testes; Epithelial cells; Catalogs; Skin; Polyps; Carcinogens; Tumors; DNA repair; Somatic cells; Cancer; Filters; Leukemia; Pores; Carcinogenesis; Down's syndrome; Mutation DO - http://dx.doi.org/10.1186/1471-2407-7-151 ER - TY - JOUR T1 - A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression data AN - 20349509; 9022970 AB - Background Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, the regulation process in genetic systems is inherently non-linear in nature, and most studies employ a time-course analysis of mRNA expression. These considerations should be taken into account in the development of methods for the inference of regulatory interactions in genetic networks. Results We use an S-system based model for the transcription and translation process. We propose an optimization-based regulatory network inference approach that uses time-varying data from DNA microarray analysis. Currently, this seems to be the only model-based method that can be used for the analysis of time-course "relative" expressions (expression ratios). We perform an analysis of the dynamic behavior of the system when the number of experimental samples available is varied, when there are different levels of noise in the data and when there are genes that are not considered by the experimenter. Our studies show that the principal factor affecting the ability of a method to infer interactions correctly is the similarity in the time profiles of some or all the genes. The less similar the profiles are to each other the easier it is to infer the interactions. We propose a heuristic method for resolving networks and show that it displays reasonable performance on a synthetic network. Finally, we validate our approach using real experimental data for a chosen subset of genes involved in the sporulation cascade of Bacillus anthracis. We show that the method captures most of the important known interactions between the chosen genes. Conclusion The performance of any inference method for regulatory interactions between genes depends on the noise in the data, the existence of unknown genes affecting the network genes, and the similarity in the time profiles of some or all genes. Though subject to these issues, the inference method proposed in this paper would be useful because of its ability to infer important interactions, the fact that it can be used with time-course DNA microarray data and because it is based on a non-linear model of the process that explicitly accounts for the regulatory role of proteins. JF - BMC Bioinformatics AU - Thomas, Reuben AU - Paredes, Carlos J AU - Mehrotra, Sanjay AU - Hatzimanikatis, Vassily AU - Papoutsakis, Eleftherios T AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA, ThomasR3@niehs.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 228 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Translation KW - Data processing KW - Sporulation KW - Transcription KW - Problem solving KW - Bioinformatics KW - Bacillus anthracis KW - DNA microarrays KW - Models KW - J 02320:Cell Biology KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20349509?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=A+model-based+optimization+framework+for+the+inference+of+regulatory+interactions+using+time-course+DNA+microarray+expression+data&rft.au=Thomas%2C+Reuben%3BParedes%2C+Carlos+J%3BMehrotra%2C+Sanjay%3BHatzimanikatis%2C+Vassily%3BPapoutsakis%2C+Eleftherios+T&rft.aulast=Thomas&rft.aufirst=Reuben&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=228&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-228 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Translation; Data processing; Sporulation; Problem solving; Transcription; Bioinformatics; DNA microarrays; Models; Bacillus anthracis DO - http://dx.doi.org/10.1186/1471-2105-8-228 ER - TY - JOUR T1 - Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor AN - 20348018; 9023719 AB - Background Ovarian folliculogenesis in mammals is a complex process involving interactions between germ and somatic cells. Carefully orchestrated expression of transcription factors, cell adhesion molecules and growth factors are required for success. We have identified a germ-cell specific, basic helix-loop-helix transcription factor, FIGLA (Factor In the GermLine, Alpha) and demonstrated its involvement in two independent developmental processes: formation of the primordial follicle and coordinate expression of zona pellucida genes. Results Taking advantage of Figla null mouse lines, we have used a combined approach of microarray and Serial Analysis of Gene Expression (SAGE) to identify potential downstream target genes. Using high stringent cutoffs, we find that FIGLA functions as a key regulatory molecule in coordinating expression of the NALP family of genes, genes of known oocyte-specific expression and a set of functionally un-annotated genes. FIGLA also inhibits expression of male germ cell specific genes that might otherwise disrupt normal oogenesis. Conclusion These data implicate FIGLA as a central regulator of oocyte-specific genes that play roles in folliculogenesis, fertilization and early development. JF - BMC Developmental Biology AU - Joshi, Saurabh AU - Davies, Holly AU - Sims, Lauren Porter AU - Levy, Shawn E AU - Dean, Jurrien AD - Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA, saurabhj@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 67 PB - BioMed Central Ltd., Middlesex House VL - 7 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Serial analysis of gene expression KW - Data processing KW - Follicles KW - Germ cells KW - Somatic cells KW - Helix-loop-helix proteins KW - DNA microarrays KW - Fertilization KW - Zona pellucida KW - Transcription factors KW - Growth factors KW - Oogenesis KW - Cell adhesion molecules KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20348018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Developmental+Biology&rft.atitle=Ovarian+gene+expression+in+the+absence+of+FIGLA%2C+an+oocyte-specific+transcription+factor&rft.au=Joshi%2C+Saurabh%3BDavies%2C+Holly%3BSims%2C+Lauren+Porter%3BLevy%2C+Shawn+E%3BDean%2C+Jurrien&rft.aulast=Joshi&rft.aufirst=Saurabh&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=BMC+Developmental+Biology&rft.issn=1471-213X&rft_id=info:doi/10.1186%2F1471-213X-7-67 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Serial analysis of gene expression; Follicles; Germ cells; Somatic cells; DNA microarrays; Helix-loop-helix proteins; Fertilization; Zona pellucida; Transcription factors; Growth factors; Cell adhesion molecules; Oogenesis DO - http://dx.doi.org/10.1186/1471-213X-7-67 ER - TY - JOUR T1 - Accuracy of structure-based sequence alignment of automatic methods AN - 20346301; 9023095 AB - Background Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better conserved than sequence, structure alignments have been used to guide sequence alignments and are commonly used as the gold standard for sequence alignment evaluation. Nonetheless, as far as we know, there is no report of a systematic evaluation of pairwise structure alignment programs in terms of the sequence alignment accuracy. Results In this study, we evaluate CE, DaliLite, FAST, LOCK2, MATRAS, SHEBA and VAST in terms of the accuracy of the sequence alignments they produce, using sequence alignments from NCBI's human-curated Conserved Domain Database (CDD) as the standard of truth. We find that 4 to 9% of the residues on average are either not aligned or aligned with more than 8 residues of shift error and that an additional 6 to 14% of residues on average are misaligned by 1-8 residues, depending on the program and the data set used. The fraction of correctly aligned residues generally decreases as the sequence similarity decreases or as the RMSD between the C sub( alpha ) positions of the two structures increases. It varies significantly across CDD superfamilies whether shift error is allowed or not. Also, alignments with different shift errors occur between proteins within the same CDD superfamily, leading to inconsistent alignments between superfamily members. In general, residue pairs that are more than 3.0 Aa apart in the reference alignment are heavily (>= 25% on average) misaligned in the test alignments. In addition, each method shows a different pattern of relative weaknesses for different SCOP classes. CE gives relatively poor results for beta -sheet-containing structures (all- beta , alpha / beta , and alpha + beta classes), DaliLite for "others" class where all but the major four classes are combined, and LOCK2 and VAST for all- beta and "others" classes. Conclusion When the sequence similarity is low, structure-based methods produce better sequence alignments than by using sequence similarities alone. However, current structure-based methods still mis-align 11-19% of the conserved core residues when compared to the human-curated CDD alignments. The alignment quality of each program depends on the protein structural type and similarity, with DaliLite showing the most agreement with CDD on average. JF - BMC Bioinformatics AU - Kim, Changhoon AU - Lee, Byungkook AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, Maryland, USA, kimchan@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 355 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Biotechnology and Bioengineering Abstracts KW - Databases KW - Computer programs KW - Data processing KW - Homology KW - Nucleotide sequence KW - Conserved sequence KW - Bioinformatics KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20346301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Accuracy+of+structure-based+sequence+alignment+of+automatic+methods&rft.au=Kim%2C+Changhoon%3BLee%2C+Byungkook&rft.aulast=Kim&rft.aufirst=Changhoon&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-355 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Computer programs; Databases; Data processing; Homology; Nucleotide sequence; Conserved sequence; Bioinformatics; Models DO - http://dx.doi.org/10.1186/1471-2105-8-355 ER - TY - JOUR T1 - Extracting gene expression patterns and identifying co-expressed genes from microarray data reveals biologically responsive processes AN - 20342820; 9023166 AB - Background A common observation in the analysis of gene expression data is that many genes display similarity in their expression patterns and therefore appear to be co-regulated. However, the variation associated with microarray data and the complexity of the experimental designs make the acquisition of co-expressed genes a challenge. We developed a novel method for Extracting microarray gene expression Patterns and Identifying co-expressed Genes, designated as EPIG. The approach utilizes the underlying structure of gene expression data to extract patterns and identify co-expressed genes that are responsive to experimental conditions. Results Through evaluation of the correlations among profiles, the magnitude of variation in gene expression profiles, and profile signal-to-noise ratio's, EPIG extracts a set of patterns representing co-expressed genes. The method is shown to work well with a simulated data set and microarray data obtained from time-series studies of dauer recovery and L1 starvation in C. elegans and after ultraviolet (UV) or ionizing radiation (IR)-induced DNA damage in diploid human fibroblasts. With the simulated data set, EPIG extracted the appropriate number of patterns which were more stable and homogeneous than the set of patterns that were determined using the CLICK or CAST clustering algorithms. However, CLICK performed better than EPIG and CAST with respect to the average correlation between clusters/patterns of the simulated data. With real biological data, EPIG extracted more dauer-specific patterns than CLICK. Furthermore, analysis of the IR/UV data revealed 18 unique patterns and 2661 genes out of approximately 17,000 that were identified as significantly expressed and categorized to the patterns by EPIG. The time-dependent patterns displayed similar and dissimilar responses between IR and UV treatments. Gene Ontology analysis applied to each pattern-related subset of co-expressed genes revealed underlying biological processes affected by IR- and/or UV- induced DNA damage. Conclusion EPIG competed with CLICK and performed better than CAST in extracting patterns from simulated data. EPIG extracted more biological informative patterns and co-expressed genes from both C. elegans and IR/UV-treated human fibroblasts. Using Gene Ontology analysis of the genes in the patterns extracted by EPIG, several key biological categories related to p53-dependent cell cycle control were revealed from the IR/UV data. Among them were mitotic cell cycle, DNA replication, DNA repair, cell cycle checkpoint, and G sub(0)-like status transition. EPIG can be applied to data sets from a variety of experimental designs. JF - BMC Bioinformatics AU - Chou, Jeff W AU - Zhou, Tong AU - Kaufmann, William K AU - Paules, Richard S AU - Bushel, Pierre R AD - Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA, chou@niehs.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 427 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Starvation KW - DNA biosynthesis KW - Data processing KW - Diploids KW - Replication KW - Cell cycle KW - Algorithms KW - DNA repair KW - DNA microarrays KW - Fibroblasts KW - Gene expression KW - DNA damage KW - U.V. radiation KW - Ionizing radiation KW - Bioinformatics KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=Extracting+gene+expression+patterns+and+identifying+co-expressed+genes+from+microarray+data+reveals+biologically+responsive+processes&rft.au=Chou%2C+Jeff+W%3BZhou%2C+Tong%3BKaufmann%2C+William+K%3BPaules%2C+Richard+S%3BBushel%2C+Pierre+R&rft.aulast=Chou&rft.aufirst=Jeff&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=427&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-427 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Starvation; DNA biosynthesis; Data processing; Diploids; Replication; Cell cycle; Algorithms; DNA repair; DNA microarrays; Fibroblasts; Gene expression; DNA damage; U.V. radiation; Ionizing radiation; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-8-427 ER - TY - JOUR T1 - DAVID Knowledgebase: a gene-centered database integrating heterogeneous gene annotation resources to facilitate high-throughput gene functional analysis AN - 20342744; 9023165 AB - Background Due to the complex and distributed nature of biological research, our current biological knowledge is spread over many redundant annotation databases maintained by many independent groups. Analysts usually need to visit many of these bioinformatics databases in order to integrate comprehensive annotation information for their genes, which becomes one of the bottlenecks, particularly for the analytic task associated with a large gene list. Thus, a highly centralized and ready-to-use gene-annotation knowledgebase is in demand for high throughput gene functional analysis. Description The DAVID Knowledgebase is built around the DAVID Gene Concept, a single-linkage method to agglomerate tens of millions of gene/protein identifiers from a variety of public genomic resources into DAVID gene clusters. The grouping of such identifiers improves the cross-reference capability, particularly across NCBI and UniProt systems, enabling more than 40 publicly available functional annotation sources to be comprehensively integrated and centralized by the DAVID gene clusters. The simple, pair-wise, text format files which make up the DAVID Knowledgebase are freely downloadable for various data analysis uses. In addition, a well organized web interface allows users to query different types of heterogeneous annotations in a high-throughput manner. Conclusion The DAVID Knowledgebase is designed to facilitate high throughput gene functional analysis. For a given gene list, it not only provides the quick accessibility to a wide range of heterogeneous annotation data in a centralized location, but also enriches the level of biological information for an individual gene. Moreover, the entire DAVID Knowledgebase is freely downloadable or searchable at . JF - BMC Bioinformatics AU - Sherman, Brad T AU - Huang, Da Wei AU - Tan, Qina AU - Guo, Yongjian AU - Bour, Stephan AU - Liu, David AU - Stephens, Robert AU - Baseler, Michael W AU - Lane, H Clifford AU - Lempicki, Richard A AD - Laboratory of Immunopathogenesis and Bioinformatics, Clinical Services Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702, USA, bsherman@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 426 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Databases KW - Data processing KW - Information processing KW - Gene clusters KW - Proteins KW - Bioinformatics KW - genomics KW - G 07880:Human Genetics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20342744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=DAVID+Knowledgebase%3A+a+gene-centered+database+integrating+heterogeneous+gene+annotation+resources+to+facilitate+high-throughput+gene+functional+analysis&rft.au=Sherman%2C+Brad+T%3BHuang%2C+Da+Wei%3BTan%2C+Qina%3BGuo%2C+Yongjian%3BBour%2C+Stephan%3BLiu%2C+David%3BStephens%2C+Robert%3BBaseler%2C+Michael+W%3BLane%2C+H+Clifford%3BLempicki%2C+Richard+A&rft.aulast=Sherman&rft.aufirst=Brad&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-426 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Databases; Data processing; Information processing; Gene clusters; Proteins; genomics; Bioinformatics DO - http://dx.doi.org/10.1186/1471-2105-8-426 ER - TY - JOUR T1 - SEARCHPATTOOL: a new method for mining the most specific frequent patterns for binding sites with application to prokaryotic DNA sequences AN - 20341722; 9023094 AB - Background Computational methods to predict transcription factor binding sites (TFBS) based on exhaustive algorithms are guaranteed to find the best patterns but are often limited to short ones or impose some constraints on the pattern type. Many patterns for binding sites in prokaryotic species are not well characterized but are known to be large, between 16-30 base pairs (bp) and contain at least 2 conserved bases. The length of prokaryotic species promoters (about 400 bp) and our interest in studying a small set of genes that could be a cluster of co-regulated genes from microarray experiments led to the development of a new exhaustive algorithm targeting these large patterns. Results We present Searchpattool, a new method to search for and select the most specific (conservative) frequent patterns. This method does not impose restrictions on the density or the structure of the pattern. The best patterns (motifs) are selected using several statistics, including a new application of a z-score based on the number of matching sequences. We compared Searchpattool against other well known algorithms on a Bacillus subtilis group of 14 input sequences and found that in our experiments Searchpattool always performed the best based on performance scores. Conclusion Searchpattool is a new method for pattern discovery relative to transcription factor binding sites for species or genes with short promoters. It outputs the most specific significant patterns and helps the biologist to choose the best candidates. JF - BMC Bioinformatics AU - Elloumi, Fathi AU - Nason, Martha AD - Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 9000 Rockville Pike, Blg50/R5505, Bethesda, MD 20892, USA, elloumi.fathi@epa.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 354 PB - BioMed Central Ltd., Middlesex House VL - 8 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Promoters KW - Bacillus subtilis KW - Statistics KW - Transcription factors KW - Nucleotide sequence KW - Algorithms KW - Bioinformatics KW - Computer applications KW - DNA microarrays KW - Base pairs KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20341722?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=SEARCHPATTOOL%3A+a+new+method+for+mining+the+most+specific+frequent+patterns+for+binding+sites+with+application+to+prokaryotic+DNA+sequences&rft.au=Elloumi%2C+Fathi%3BNason%2C+Martha&rft.aulast=Elloumi&rft.aufirst=Fathi&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=354&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=1471-2105&rft_id=info:doi/10.1186%2F1471-2105-8-354 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Promoters; Statistics; Nucleotide sequence; Transcription factors; Algorithms; Bioinformatics; Computer applications; DNA microarrays; Base pairs; Bacillus subtilis DO - http://dx.doi.org/10.1186/1471-2105-8-354 ER - TY - JOUR T1 - Radioligand Development for PET Imaging of beta -Amyloid (A beta )-Current Status AN - 20337349; 7653320 AB - Two of the main pathological hallmarks of Alzheimers disease (AD) are neuritic plaques and neurofibrillary tangles. Significant evidence supports a critical and probable causative role of beta amyloid (A beta ) plaque formation. Since neuroprotective treatments are typically most effective at early stages of injury, the detection and measurement of A beta load in living brain should be performed at early and perhaps even presymptomatic stages of AD. Two primary targets of molecular imaging research with positron emission tomography (PET) are to develop surrogate markers (radioligands) for assessing disease progression and for monitoring the efficacy of developmental therapeutics. Here, we review the current status of radioligand development for PET imaging of A beta aggregates. General structure-activity relationships have emerged, including the identification of at least three different ligand binding sites in various A beta aggregates and recognition of the general structural requirements for ligand binding at each site. Also a few radioligands applicable to imaging A beta plaques in living human brain with positron emission tomography (PET) have emerged, including [11C]PIB, [11C]SB- 13 and [18F]FDDNP. JF - Current Medicinal Chemistry AU - Cai, Lisheng AU - Innis, Robert B AU - Pike, Victor W AD - Molecular Imaging Branch,National Institute of Mental Health, National Institutes of Health, Bethesda,MD 20892, USA. Y1 - 2007 PY - 2007 DA - 2007 SP - 19 EP - 52 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 14 IS - 1 SN - 0929-8673, 0929-8673 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - PET imaging KW - beta -amyloid KW - radioligand KW - assay KW - Alzheimers disease KW - Neuroimaging KW - Brain injury KW - Alzheimer's disease KW - Brain KW - Neuroprotection KW - Neurodegenerative diseases KW - Reviews KW - Computed tomography KW - Positron emission tomography KW - Plaques KW - Neurofibrillary tangles KW - beta -Amyloid KW - Structure-activity relationships KW - W 30910:Imaging KW - N3 11028:Neuropharmacology & toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20337349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Medicinal+Chemistry&rft.atitle=Radioligand+Development+for+PET+Imaging+of+beta+-Amyloid+%28A+beta+%29-Current+Status&rft.au=Cai%2C+Lisheng%3BInnis%2C+Robert+B%3BPike%2C+Victor+W&rft.aulast=Cai&rft.aufirst=Lisheng&rft.date=2007-01-01&rft.volume=14&rft.issue=1&rft.spage=19&rft.isbn=&rft.btitle=&rft.title=Current+Medicinal+Chemistry&rft.issn=09298673&rft_id=info:doi/10.2174%2F092986707779313471 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Neuroimaging; Brain injury; Alzheimer's disease; Brain; Neuroprotection; Neurodegenerative diseases; Reviews; Computed tomography; Positron emission tomography; Plaques; beta -Amyloid; Neurofibrillary tangles; Structure-activity relationships DO - http://dx.doi.org/10.2174/092986707779313471 ER - TY - JOUR T1 - Rational Modifications of HIV-1 Envelope Glycoproteins for Immunogen Design AN - 20318255; 7654936 AB - An effective vaccine against the human immunodeficiency virus type 1 (HIV-1) will likely require the elicitation of broadly neutralizing antibodies as well as cellular responses. The HIV exterior envelope glycoprotein trimers, gp120, and the transmembrane glycoprotein, gp41, mediate entry and are the sole viral targets for neutralizing antibodies. However, as subunit immunogens the envelope glycoproteins do not efficiently elicit antibodies capable of neutralizing the extremely diverse array of viruses circulating in the human population. The preponderance of data suggest that inefficient generation of broadly neutralizing antibodies is due to naturally evolved mechanisms of immune evasion inherent in the unmodified HIV envelope glycoproteins. Because the established modes of anti-viral vaccine development, liveattenuation and virus inactivation have not yet been successful for HIV, we and others have focused on subunit vaccine design. In this review, we describe current approaches of rational modification of the envelope glycoproteins based upon structure, antigenicity, biochemistry and biophysics to alter the properties of the envelope glycoproteins such that, as subunit immunogens, they now better elicit broadly neutralizing antibodies. The application of structure-assisted, rational subunit vaccine design may be a general paradigm for future efforts to develop vaccines against emerging human pathogens. JF - Current Pharmaceutical Design AU - Phogat, S AU - Wyatt, R AD - Structural Virology Section,Vaccine Research Center, National Institutes of Health, 40 Convent Dr.,Bldg. 40, Room 4512, Bethesda, MD 20892-3005, USA. Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 213 EP - 227 PB - Bentham Science Publishers B.V., P.O. Box 1673 Hilversum 1200 BR The Netherlands, [mailto:shidding@worldonline.nl], [URL:http://www.bentham.org] VL - 13 IS - 2 SN - 1381-6128, 1381-6128 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - HIV vaccine KW - envelope glycoproteins KW - structure-assisted immunogen design KW - Data processing KW - glycoprotein gp41 KW - Antigenicity KW - Pathogens KW - Biophysics KW - Glycoprotein gp120 KW - Antibodies KW - Envelopes KW - Antiviral agents KW - Reviews KW - Human immunodeficiency virus 1 KW - Vaccines KW - V 22360:AIDS and HIV KW - F 06955:Immunomodulation & Immunopharmacology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20318255?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Pharmaceutical+Design&rft.atitle=Rational+Modifications+of+HIV-1+Envelope+Glycoproteins+for+Immunogen+Design&rft.au=Phogat%2C+S%3BWyatt%2C+R&rft.aulast=Phogat&rft.aufirst=S&rft.date=2007-01-01&rft.volume=13&rft.issue=2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Current+Pharmaceutical+Design&rft.issn=13816128&rft_id=info:doi/10.2174%2F138161207779313632 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-11-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Glycoprotein gp120; Antibodies; Data processing; Envelopes; glycoprotein gp41; Antiviral agents; Antigenicity; Reviews; Pathogens; Vaccines; Biophysics; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.2174/138161207779313632 ER - TY - JOUR T1 - Exercise Capacity of Cardiac Asymptomatic Hereditary Hemochromatosis Subjects AN - 20254667; 7300969 AB - Purpose: The exercise capacity of cardiac asymptomatic subjects with hereditary hemochromatosis (HH) has not been well described. In this study, we tested whether the iron overload associated with HH affected exercise capacity with a case control study design. Methods: Forty-three HH and 21 normal control subjects who were New York Heart Association functional class I underwent metabolic stress testing using the Bruce protocol at the clinical center of the National Institutes of Health. Exercise capacity was assessed with minute ventilation (V sub(E)), oxygen uptake (VO sub(2)), and carbon dioxide production (VCO sub(2)) using a breath-by-breath respiratory gas analyzer. Results: The exercise capacity of HH subjects was not statistically different from that of control subjects (exercise time 564 plus or minus 135 vs 673 plus or minus 175 s, P = 0.191; peak VO sub(2) 29.6 plus or minus 6.4 vs 32.5 plus or minus 6.7 mL times kg super(-1) times min super(-1), P = 0.109; ventilatory threshold 19.0 plus or minus 3.4 vs 21.0 plus or minus 5.0 mL times min super(-1) times kg super(-1), P = 0.099; data are for HH vs control subjects). Ventilatory efficiency was comparable between groups (V sub(E)/VCO sub(2) slope 23.7 plus or minus 3.2 vs 23.4 plus or minus 4.2, P = 0.791). No significant correlation between the markers of iron levels and the markers of exercise capacity was noted. Iron depletion by 6-month phlebotomy therapy in 18 subjects who were newly diagnosed did not affect exercise testing variables (exercise time 562 plus or minus 119 vs 579 plus or minus 118 s, P = 0.691; peak VO sub(2) 29.5 plus or minus 3.7 vs 29.1 plus or minus 4.7 mL times kg super(-1) times min super(-1), P = 0.600; ventilatory threshold 18.5 plus or minus 2.8 vs 17.9 plus or minus 3.8 mL times kg super(-1) times min super(-1), P = 0.651; data are from before and after phlebotomy therapy). Abnormal ischemic electrocardiographic responses and complex arrhythmias were more frequently seen in HH subjects. Conclusions: The aerobic exercise capacity of asymptomatic HH subjects seems not to be statistically different from that of normal subjects. The iron levels do not seem to affect exercise capacity in asymptomatic HH subjects. JF - Medicine & Science in Sports & Exercise AU - Shizukuda, Y AU - Bolan, C D AU - Tripodi, D J AU - Yau, Y-Y AU - Smith, K P AU - Arena, R AU - Waclawiw, MA AU - Leitman, S F AU - Rosing AD - Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bldg. 10-CRC, Rm. 6-3142, MSC-1454, 10 Center Drive, Bethesda, MD, 20892, USA, shizukuy@nhlbi.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 3 EP - 7 VL - 39 IS - 1 SN - 0195-9131, 0195-9131 KW - Physical Education Index KW - Heart KW - Statistics KW - Aerobics KW - Pulmonary ventilation KW - Therapy KW - Stress KW - Sport science KW - Health KW - Exercise KW - Efficiency KW - Ventilatory threshold KW - Carbon dioxide KW - Maximum oxygen consumption KW - Iron KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20254667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medicine+%26+Science+in+Sports+%26+Exercise&rft.atitle=Exercise+Capacity+of+Cardiac+Asymptomatic+Hereditary+Hemochromatosis+Subjects&rft.au=Shizukuda%2C+Y%3BBolan%2C+C+D%3BTripodi%2C+D+J%3BYau%2C+Y-Y%3BSmith%2C+K+P%3BArena%2C+R%3BWaclawiw%2C+MA%3BLeitman%2C+S+F%3BRosing&rft.aulast=Shizukuda&rft.aufirst=Y&rft.date=2007-01-01&rft.volume=39&rft.issue=1&rft.spage=3&rft.isbn=&rft.btitle=&rft.title=Medicine+%26+Science+in+Sports+%26+Exercise&rft.issn=01959131&rft_id=info:doi/10.1249%2F01.mss.0000240323.08406.f3 LA - English DB - Physical Education Index N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Statistics; Aerobics; Pulmonary ventilation; Therapy; Sport science; Stress; Health; Exercise; Efficiency; Ventilatory threshold; Carbon dioxide; Iron; Maximum oxygen consumption DO - http://dx.doi.org/10.1249/01.mss.0000240323.08406.f3 ER - TY - JOUR T1 - RNAi Therapy for HIV Infection: Principles and Practicalities AN - 20251749; 7478977 AB - Inside eukaryotic cells, small RNA duplexes, called small interfering RNAs (siRNAs), activate a conserved RNA interference (RNAi) pathway which leads to specific degradation of complementary target mRNAs through base-pairing recognition. As with other viruses, studies have shown that replication of the HIV-1 in cultured cells can be targeted and inhibited by synthetic siRNAs. The relative ease of siRNA design and the versatility of RNAi to target a broad spectrum of mRNAs have led to the promise that drug discovery in the RNAi pathway could be effective against pathogens. This review discusses the current experimental principles that guide the application of RNAi against HIV and describes challenges and limitations that need to be surmounted in order for siRNAs to become practical antiviral drugs. The practical use of RNAi therapy for HIV infection will depend on overcoming several challenges, including the ability to establish long-term expression of siRNA without off-target effects and the capacity to counteract mutant escape viruses. JF - BioDrugs AU - Bennasser, Yamina AU - Man Lung Yeung, AU - Jeang, Kuan-Teh AD - Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 17 EP - 22 PB - Adis International Ltd., 41 Centorian Drive Private Bay 65901, Mairangi Bay Auckland 10 New Zealand, [mailto:sportsmed@adis.co.nz], [URL:http://www.adis.com] VL - 21 IS - 1 SN - 1173-8804, 1173-8804 KW - Virology & AIDS Abstracts; Biotechnology Research Abstracts (through 1992) KW - Replication KW - Drug development KW - Pathogens KW - Infection KW - mRNA KW - Drug discovery KW - Antiviral agents KW - siRNA KW - Reviews KW - Human immunodeficiency virus 1 KW - RNA-mediated interference KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20251749?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BioDrugs&rft.atitle=RNAi+Therapy+for+HIV+Infection%3A+Principles+and+Practicalities&rft.au=Bennasser%2C+Yamina%3BMan+Lung+Yeung%2C%3BJeang%2C+Kuan-Teh&rft.aulast=Bennasser&rft.aufirst=Yamina&rft.date=2007-01-01&rft.volume=21&rft.issue=1&rft.spage=17&rft.isbn=&rft.btitle=&rft.title=BioDrugs&rft.issn=11738804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; siRNA; RNA-mediated interference; mRNA; Infection; Drug discovery; Drug development; Pathogens; Replication; Reviews; Antiviral agents ER - TY - JOUR T1 - Sentra: a database of signal transduction proteins for comparative genome analysis AN - 20245598; 7254414 AB - Sentra (http://compbio.mcs.anl.gov/sentra), a database of signal transduction proteins encoded in completely sequenced prokaryotic genomes, has been updated to reflect recent advances in understanding signal transduction events on a whole-genome scale. Sentra consists of two principal components, a manually curated list of signal transduction proteins in 202 completely sequenced prokaryotic genomes and an automatically generated listing of predicted signaling proteins in 235 sequenced genomes that are awaiting manual curation. In addition to two-component histidine kinases and response regulators, the database now lists manually curated Ser/Thr/Tyr protein kinases and protein phosphatases, as well as adenylate and diguanylate cyclases and c-di-GMP phosphodiesterases, as defined in several recent reviews. All entries in Sentra are extensively annotated with relevant information from public databases (e.g. UniProt, KEGG, PDB and NCBI). Sentra's infrastructure was redesigned to support interactive cross-genome comparisons of signal transduction capabilities of prokaryotic organisms from a taxonomic and phenotypic perspective and in the framework of signal transduction pathways from KEGG. Sentra leverages the PUMA2 system to support interactive analysis and annotation of signal transduction proteins by the users. JF - Nucleic Acids Research AU - D'Souza, Mark AU - Glass, Elizabeth M AU - Syed, Mustafa H AU - Zhang, Yi AU - Rodriguez, Alexis AU - Maltsev, Natalia AU - Galperin, Michael Y AD - Computational Biology Group, Mathematics and Computer Science Division, Argonne National Laboratory Argonne, IL 60439, USA. Computation Institute, University of Chicago Chicago, IL 60637, USA. National Center for Biotechnology Information, National Library of Medicine MSC3830, National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D271 EP - D273 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Histidine kinase KW - Databases KW - Reviews KW - Protein kinase KW - protein phosphatase KW - phosphodiesterase KW - Signal transduction KW - G 07740:Evolution KW - N 14845:Miscellaneous KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20245598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Sentra%3A+a+database+of+signal+transduction+proteins+for+comparative+genome+analysis&rft.au=D%27Souza%2C+Mark%3BGlass%2C+Elizabeth+M%3BSyed%2C+Mustafa+H%3BZhang%2C+Yi%3BRodriguez%2C+Alexis%3BMaltsev%2C+Natalia%3BGalperin%2C+Michael+Y&rft.aulast=D%27Souza&rft.aufirst=Mark&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D271&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Histidine kinase; Genomes; Databases; Reviews; Protein kinase; protein phosphatase; phosphodiesterase; Signal transduction ER - TY - JOUR T1 - Critical Review of Published Microarray Studies for Cancer Outcome and Guidelines on Statistical Analysis and Reporting AN - 20226101; 7253589 AB - BACKGROUND: Both the validity and the reproducibility of microarray-based clinical research have been challenged. There is a need for critical review of the statistical analysis and reporting in published microarray studies that focus on cancer-related clinical outcomes. METHODS: Studies published through 2004 in which microarray-based gene expression profiles were analyzed for their relation to a clinical cancer outcome were identified through a Medline search followed by hand screening of abstracts and full text articles. Studies that were eligible for our analysis addressed one or more outcomes that were either an event occurring during follow-up, such as death or relapse, or a therapeutic response. We recorded descriptive characteristics for all the selected studies. A critical review of outcome-related statistical analyses was undertaken for the articles published in 2004. RESULTS: Ninety studies were identified, and their descriptive characteristics are presented. Sixty-eight (76%) were published in journals of impact factor greater than 6. A detailed account of the 42 studies (47%) published in 2004 is reported. Twenty-one (50%) of them contained at least one of the following three basic flaws: 1) in outcome-related gene finding, an unstated, unclear, or inadequate control for multiple testing; 2) in class discovery, a spurious claim of correlation between clusters and clinical outcome, made after clustering samples using a selection of outcome-related differentially expressed genes; or 3) in supervised prediction, a biased estimation of the prediction accuracy through an incorrect cross-validation procedure. CONCLUSIONS: The most common and serious mistakes and misunderstandings recorded in published studies are described and illustrated. Based on this analysis, a proposal of guidelines for statistical analysis and reporting for clinical microarray studies, presented as a checklist of "Do's and Don'ts," is provided. JF - Journal of the National Cancer Institute AU - Dupuy, Alain AU - Simon, Richard M AD - Biometric Research Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD (AD, RMS) Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 147 EP - 157 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 99 IS - 2 SN - 0027-8874, 0027-8874 KW - Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Reviews KW - Statistical analysis KW - Check lists KW - Hand KW - DNA microarrays KW - Cancer KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20226101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Critical+Review+of+Published+Microarray+Studies+for+Cancer+Outcome+and+Guidelines+on+Statistical+Analysis+and+Reporting&rft.au=Dupuy%2C+Alain%3BSimon%2C+Richard+M&rft.aulast=Dupuy&rft.aufirst=Alain&rft.date=2007-01-01&rft.volume=99&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Gene expression; Reviews; Statistical analysis; Hand; Check lists; DNA microarrays; Cancer ER - TY - JOUR T1 - Elicitation of T Cell Responses to Histologically Unrelated Tumors by Immunization with the Novel Cancer-Testis Antigen, Brother of the Regulator of Imprinted Sites AN - 20136920; 7209010 AB - Brother of the regulator of imprinted sites (BORIS) was previously described as a transcription factor for epigenetic reprogramming the expression of which is strictly confined to germ cells of adult testes but is aberrantly activated in the vast majority of neoplastic cells. Considering the critical role of BORIS in cancerogenesis and the fact that its expression pattern may preclude thymic tolerance, we generated DNA- and protein-based mouse BORIS antitumor vaccines using a non-DNA-binding version of the BORIS molecule. Clinical use of BORIS as a vaccine Ag would require that certain safety concerns be met. Specifically, administration of the functional BORIS protein would hypothetically pose a risk of BORIS accelerating the progression of cancer. To alleviate such safety concerns, we have developed vaccines based on the BORIS molecule lacking the DNA-binding zinc fingers domain. To enhance anti-BORIS cellular immune responses, we used a standard molecular adjuvant approach. It consisted of plasmids encoding murine IL-12 and IL-18 for a DNA-based vaccine and conventional Th1 type adjuvant, Quil A, for a protein-based vaccine. Both DNA- and protein-based vaccines induced Ag-specific CD4 super(+) T cell proliferation with Th1 and Th2 cytokine profiles, respectively. Protein-based, but not DNA-based, BORIS vaccine induced a significant level of Ab production in immunized animals. Importantly, potent anticancer CD8 super(+)-cytotoxic lymphocytes were generated after immunization with the DNA-based, but not protein-based, BORIS vaccine. These cytolytic responses were observed across a wide range of different mouse cancers including mammary adenocarcinoma, glioma, leukemia, and mastocytoma. JF - Journal of Immunology AU - Ghochikyan, Anahit AU - Mkrtichyan, Mikayel AU - Loukinov, Dmitri AU - Mamikonyan, Gregory AU - Pack, Svetlana D AU - Movsesyan, Nina AU - Ichim, Thomas E AU - Cribbs, David H AU - Lobanenkov, Victor V AU - Agadjanyan, Michael G AD - Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, CA 92647. Department of Neurology, Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852. OncoMune Inc., Miami, FL 33122 Y1 - 2007/01/01/ PY - 2007 DA - 2007 Jan 01 SP - 566 EP - 573 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 1 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Immunology Abstracts KW - Testes KW - Helper cells KW - mastocytoma KW - Zinc finger proteins KW - Adjuvants KW - Leukemia KW - Interleukin 12 KW - CD4 antigen KW - DNA vaccines KW - epigenetics KW - Interleukin 18 KW - Lymphocytes T KW - Glioma KW - Thymus KW - Germ cells KW - Tumors KW - Plasmids KW - Immunological tolerance KW - Immunization KW - Brain tumors KW - Antibodies KW - Transcription factors KW - Vaccines KW - Adenocarcinoma KW - Cell proliferation KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20136920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Elicitation+of+T+Cell+Responses+to+Histologically+Unrelated+Tumors+by+Immunization+with+the+Novel+Cancer-Testis+Antigen%2C+Brother+of+the+Regulator+of+Imprinted+Sites&rft.au=Ghochikyan%2C+Anahit%3BMkrtichyan%2C+Mikayel%3BLoukinov%2C+Dmitri%3BMamikonyan%2C+Gregory%3BPack%2C+Svetlana+D%3BMovsesyan%2C+Nina%3BIchim%2C+Thomas+E%3BCribbs%2C+David+H%3BLobanenkov%2C+Victor+V%3BAgadjanyan%2C+Michael+G&rft.aulast=Ghochikyan&rft.aufirst=Anahit&rft.date=2007-01-01&rft.volume=178&rft.issue=1&rft.spage=566&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Testes; Helper cells; mastocytoma; Zinc finger proteins; Adjuvants; Interleukin 12; Leukemia; CD4 antigen; DNA vaccines; epigenetics; Interleukin 18; Lymphocytes T; Glioma; Thymus; Germ cells; Tumors; Plasmids; Immunological tolerance; Immunization; Brain tumors; Antibodies; Transcription factors; Vaccines; Cell proliferation; Adenocarcinoma ER - TY - JOUR T1 - Rapamycin induces feedback activation of Akt signaling through an IGF-1R- dependent mechanism AN - 20130856; 7312764 AB - Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian target of rapamycin (mTOR) signaling by rapamycin leads to an increase of Akt phosphorylation in Rh30 and RD human rhabdomyosarcoma cell lines and xenografts, and insulin-like growth factor (IGF)-II-treated C2C12 mouse myoblasts and IGF-II-overexpressing Chinese hamster ovary cells. RNA interference-mediated knockdown of S6K1 also results in an increase of Akt phosphorylation. These data suggest that mTOR/S6K1 inhibition either by rapamycin or small interfering RNA (siRNA) triggers a negative feedback loop, resulting in the activation of Akt signaling. We next sought to investigate the mechanism of this negative feedback regulation from mTOR to Akt. Suppression of insulin receptor substrate (IRS)-1 and tuberous sclerosis complex-1 by siRNAs failed to abrogate rapamycin-induced upregulation of Akt phosphorylation in both Rh30 and RD cells. However, pretreatment with h7C10 antibody directed against insulin-like growth factor-1 receptor (IGF-1R) led to a blockade of rapamycin- induced Akt activation. Combined mTOR and IGF-1R inhibition with rapamycin and h7C10 antibody, respectively, resulted in additive inhibition of cell growth and survival. These data suggest that rapamycin mediates Akt activation through an IGF-1R-dependent mechanism. Thus, combining an mTOR inhibitor and an IGF-1R antibody/inhibitor may be an appropriate strategy to enhance mTOR-targeted anticancer therapy. JF - Oncogene AU - Wan, X AU - Harkavy, B AU - Shen, N AU - Grohar, P AU - Helman, L J AD - Molecular Oncology Section, Pediatric Oncology Branch, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, MD, USA, xiaolinw@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1932 EP - 1940 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 13 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - mTOR KW - rapamycin KW - Akt KW - IGF-1R KW - rhabdomyosarcoma KW - Cell survival KW - tuberous sclerosis KW - Insulin-like growth factor I KW - Data processing KW - Antitumor agents KW - Insulin receptors KW - Antibodies KW - Phosphorylation KW - siRNA KW - Insulin-like growth factors KW - AKT protein KW - Myoblasts KW - Feedback KW - Xenografts KW - TOR protein KW - Rapamycin KW - Rhabdomyosarcoma KW - Signal transduction KW - B 26600:Tyrosine Kinase Activity KW - W 30915:Pharmaceuticals & Vaccines KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20130856?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Rapamycin+induces+feedback+activation+of+Akt+signaling+through+an+IGF-1R-+dependent+mechanism&rft.au=Wan%2C+X%3BHarkavy%2C+B%3BShen%2C+N%3BGrohar%2C+P%3BHelman%2C+L+J&rft.aulast=Wan&rft.aufirst=X&rft.date=2007-01-01&rft.volume=26&rft.issue=13&rft.spage=1932&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1209990%3B LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - tuberous sclerosis; Cell survival; Insulin-like growth factor I; Data processing; Insulin receptors; Antitumor agents; Antibodies; siRNA; Phosphorylation; Insulin-like growth factors; Myoblasts; AKT protein; Feedback; Xenografts; TOR protein; Rapamycin; Signal transduction; Rhabdomyosarcoma DO - http://dx.doi.org/10.1038/sj.onc.1209990; ER - TY - JOUR T1 - NATsDB: Natural Antisense Transcripts DataBase AN - 20129258; 7254386 AB - Natural antisense transcripts (NATs) are reverse complementary at least in part to the sequences of other endogenous sense transcripts. Most NATs are transcribed from opposite strands of their sense partners. They regulate sense genes at multiple levels and are implicated in various diseases. Using an improved whole-genome computational pipeline, we identified abundant cis-encoded exon-overlapping sense-antisense (SA) gene pairs in human (7356), mouse (6806), fly (1554), and eight other eukaryotic species (total 6534). We developed NATsDB (Natural Antisense Transcripts DataBase, http://natsdb.cbi.pku.edu.cn/) to enable efficient browsing, searching and downloading of this currently most comprehensive collection of SA genes, grouped into six classes based on their overlapping patterns. NATsDB also includes non-exon-overlapping bidirectional (NOB) genes and non-bidirectional (NBD) genes. To facilitate the study of functions, regulations and possible pathological implications, NATsDB includes extensive information about gene structures, poly(A) signals and tails, phastCons conservation, homologues in other species, repeat elements, expressed sequence tag (EST) expression profiles and OMIM disease association. NATsDB supports interactive graphical display of the alignment of all supporting EST and mRNA transcripts of the SA and NOB genes to the genomic loci. It supports advanced search by species, gene name, sequence accession number, chromosome location, coding potential, OMIM association and sequence similarity. JF - Nucleic Acids Research AU - Zhang, Yong AU - Li, Jiongtang AU - Kong, Lei AU - Gao, Ge AU - Liu, Qing-Rong AU - Wei, Liping AD - Center for Bioinformatics, National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University Beijing 100871, PR China. Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program (NIDA-IRP), NIH, Department of Health and Human Services (DHHS) Box 5180, Baltimore, MD 21224, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D156 EP - D161 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Tails KW - Computer applications KW - expressed sequence tags KW - double prime sA gene KW - Gene expression KW - Databases KW - Antisense KW - Chromosomes KW - sA gene KW - Browsing KW - Conserved sequence KW - genomics KW - N 14840:Antisense, Nucleotide Analogs KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20129258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=NATsDB%3A+Natural+Antisense+Transcripts+DataBase&rft.au=Zhang%2C+Yong%3BLi%2C+Jiongtang%3BKong%2C+Lei%3BGao%2C+Ge%3BLiu%2C+Qing-Rong%3BWei%2C+Liping&rft.aulast=Zhang&rft.aufirst=Yong&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D156&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Databases; Chromosomes; Antisense; sA gene; Tails; Browsing; Conserved sequence; genomics; Computer applications; expressed sequence tags; double prime sA gene ER - TY - JOUR T1 - Analysis of Gene Coexpression by B-Spline Based CoD Estimation AN - 20064489; 9319928 AB - The gene coexpression study has emerged as a novel holistic approach for microarray data analysis. Different indices have been used in exploring coexpression relationship, but each is associated with certain pitfalls. The Pearson's correlation coefficient, for example, is not capable of uncovering nonlinear pattern and directionality of coexpression. Mutual information can detect nonlinearity but fails to show directionality. The coefficient of determination (CoD) is unique in exploring different patterns of gene coexpression, but so far only applied to discrete data and the conversion of continuous microarray data to the discrete format could lead to information loss. Here, we proposed an effective algorithm, CoexPro, for gene coexpression analysis. The new algorithm is based on B-spline approximation of coexpression between a pair of genes, followed by CoD estimation. The algorithm was justified by simulation studies and by functional semantic similarity analysis. The proposed algorithm is capable of uncovering both linear and a specific class of nonlinear relationships from continuous microarray data. It can also provide suggestions for possible directionality of coexpression to the researchers. The new algorithm presents a novel model for gene coexpression and will be a valuable tool for a variety of gene expression and network studies. The application of the algorithm was demonstrated by an analysis on ligand-receptor coexpression in cancerous and noncancerous cells. The software implementing the algorithm is available upon request to the authors. JF - Eurasip Journal on Bioinformatics and Systems Biology AU - Li, Huai AU - Sun, Yu AU - Zhan, Ming AD - Bioinformatics Unit Branch of Research Resources National Institute on Aging National Institutes of Health Baltimore MD 21224 USA, huaili@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - Hindawi Publishing Corporation, P.O. Box 3079 VL - 2007 SN - 1687-4145, 1687-4145 KW - Biotechnology and Bioengineering Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20064489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.atitle=Analysis+of+Gene+Coexpression+by+B-Spline+Based+CoD+Estimation&rft.au=Li%2C+Huai%3BSun%2C+Yu%3BZhan%2C+Ming&rft.aulast=Li&rft.aufirst=Huai&rft.date=2007-01-01&rft.volume=2007&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Eurasip+Journal+on+Bioinformatics+and+Systems+Biology&rft.issn=16874145&rft_id=info:doi/10.1155%2F2007%2F49478 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1155/2007/49478 ER - TY - JOUR T1 - Protein Secretion in Gram-Negative Bacteria Via the Autotransporter Pathway AN - 20028766; 8190385 AB - Autotransporters are a large and diverse superfamily of proteins produced by pathogenic gram-negative bacteria that are composed of an N-terminal passenger domain, which typically harbors a virulence function, and a C- terminal beta domain. It has long been known that the beta domain anchors the protein to the outer membrane and facilitates transport of the passenger domain into the extracellular space. Despite the apparent simplicity of the autotransporter pathway, several aspects of autotransporter biogenesis remain poorly understood, most notably the mechanism by which the passenger domain is translocated across the outer membrane. Here we review recent evidence that the enormous sequence diversity of both passenger and beta domains belies a remarkable conservation of structure. We also discuss insights into each stage of autotransporter biogenesis that have emerged from recent structural, biochemical, and imaging studies. JF - Annual Review of Microbiology AU - Dautin, Nathalie AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0538, nathalied@niddk.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 89 EP - 112 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 61 SN - 0066-4227, 0066-4227 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Reviews KW - Gram-negative bacteria KW - Secretion KW - Outer membranes KW - Conserved sequence KW - imaging KW - J 02330:Biochemistry KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20028766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Microbiology&rft.atitle=Protein+Secretion+in+Gram-Negative+Bacteria+Via+the+Autotransporter+Pathway&rft.au=Dautin%2C+Nathalie%3BBernstein%2C+Harris+D&rft.aulast=Dautin&rft.aufirst=Nathalie&rft.date=2007-01-01&rft.volume=61&rft.issue=&rft.spage=89&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Microbiology&rft.issn=00664227&rft_id=info:doi/10.1146%2Fannurev.micro.61.080706.093233 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Virulence; Secretion; Gram-negative bacteria; Reviews; Outer membranes; Conserved sequence; imaging DO - http://dx.doi.org/10.1146/annurev.micro.61.080706.093233 ER - TY - JOUR T1 - Probe Diffusion in Aqueous Poly(vinyl alcohol) Solutions Studied by Fluorescence Correlation Spectroscopy AN - 20023239; 8018748 AB - We report fluorescence correlation spectroscopy measurements of the translational diffusion coefficient of various probe particles in dilute and semidilute aqueous poly(vinyl alcohol) solutions. The range of sizes of the particles (fluorescent molecules, proteins, and polymers) was chosen to explore various length scales of the polymer solutions as defined by the polymer-polymer correlation length. For particles larger than the correlation length, we find that the diffusion coefficient, D, decreases exponentially with the polymer concentration. This can be explained by an exponential increase in the solution viscosity, consistent with the Stokes- Einstein equation. For probes on the order of the correlation length, the decrease of the diffusion coefficient cannot be accounted for by the Stokes- Einstein equation, but can be fit by a stretched exponential, D similar to exp(- alphac super(n)), where we find n = 0.73-0.84 and alpha is related to the probe size. These results are in accord with a diffusion model of Langevin and Rondelez (Polymer 1978, 19, 1875), where these values of n indicate a good solvent quality. JF - Biomacromolecules AU - Michelman-Ribeiro, Ariel AU - Horkay, Ferenc AU - Nossal, Ralph AU - Boukari, Hacene AD - Laboratory of Integrative and Medical Biophysics, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 1595 EP - 1600 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 8 IS - 5 SN - 1525-7797, 1525-7797 KW - Biotechnology and Bioengineering Abstracts KW - Translation KW - fluorescence spectroscopy KW - Mathematical models KW - Viscosity KW - alcohols KW - Probes KW - Solvents KW - Fluorescent indicators KW - Diffusion coefficient KW - Models KW - W 30935:Food Biotechnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20023239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=Probe+Diffusion+in+Aqueous+Poly%28vinyl+alcohol%29+Solutions+Studied+by+Fluorescence+Correlation+Spectroscopy&rft.au=Michelman-Ribeiro%2C+Ariel%3BHorkay%2C+Ferenc%3BNossal%2C+Ralph%3BBoukari%2C+Hacene&rft.aulast=Michelman-Ribeiro&rft.aufirst=Ariel&rft.date=2007-01-01&rft.volume=8&rft.issue=5&rft.spage=1595&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=15257797&rft_id=info:doi/10.1021%2Fbm061195rPII%3AS1525-7797%2806%2901195-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Translation; fluorescence spectroscopy; Viscosity; Mathematical models; Solvents; Probes; alcohols; Fluorescent indicators; Diffusion coefficient; Models DO - http://dx.doi.org/10.1021/bm061195rPII:S1525-7797(06)01195-0 ER - TY - JOUR T1 - Using Prior Knowledge in the Determination of Macromolecular Size- Distributions by Analytical Ultracentrifugation AN - 20013008; 7988864 AB - Analytical ultracentrifugation has reemerged as a widely used tool for the study of ensembles of biological macromolecules to understand, for example, their size-distribution and interactions in free solution. Such information can be obtained from the mathematical analysis of the concentration and signal gradients across the solution column and their evolution in time generated as a result of the gravitational force. In sedimentation velocity analytical ultracentrifugation, this analysis is frequently conducted using high resolution, diffusion-deconvoluted sedimentation coefficient distributions. They are based on Fredholm integral equations, which are ill-posed unless stabilized by regularization. In many fields, maximum entropy and Tikhonov-Phillips regularization are well- established and powerful approaches that calculate the most parsimonious distribution consistent with the data and prior knowledge, in accordance with Occam's razor. In the implementations available in analytical ultracentrifugation, to date, the basic assumption implied is that all sedimentation coefficients are equally likely and that the information retrieved should be condensed to the least amount possible. Frequently, however, more detailed distributions would be warranted by specific detailed prior knowledge on the macromolecular ensemble under study, such as the expectation of the sample to be monodisperse or paucidisperse or the expectation for the migration to establish a bimodal sedimentation pattern based on Gilbert-Jenkins' theory for the migration of chemically reacting systems. So far, such prior knowledge has remained largely unused in the calculation of the sedimentation coefficient or molecular weight distributions or was only applied as constraints. In the present paper, we examine how prior expectations can be built directly into the computational data analysis, conservatively in a way that honors the complete information of the experimental data, whether or not consistent with the prior expectation. Consistent with analogous results in other fields, we find that the use of available prior knowledge can have a dramatic effect on the resulting molecular weight, sedimentation coefficient, and size-and-shape distributions and can significantly increase both their sensitivity and their resolution. Further, the use of multiple alternative prior information allows us to probe the range of possible interpretations consistent with the data. JF - Biomacromolecules AU - Brown, Patrick H AU - Balbo, Andrea AU - Schuck, Peter AD - Protein Biophysics Resource, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 2011 EP - 2024 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 8 IS - 6 SN - 1525-7797, 1525-7797 KW - Biotechnology and Bioengineering Abstracts KW - Macromolecules KW - Mathematical models KW - Data processing KW - Gravity KW - Probes KW - Velocity KW - Computer applications KW - Migration KW - Ultracentrifugation KW - Information processing KW - Molecular weight KW - Sedimentation KW - Entropy KW - Evolution KW - W 30950:Waste Treatment & Pollution Clean-up UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20013008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biomacromolecules&rft.atitle=Using+Prior+Knowledge+in+the+Determination+of+Macromolecular+Size-+Distributions+by+Analytical+Ultracentrifugation&rft.au=Brown%2C+Patrick+H%3BBalbo%2C+Andrea%3BSchuck%2C+Peter&rft.aulast=Brown&rft.aufirst=Patrick&rft.date=2007-01-01&rft.volume=8&rft.issue=6&rft.spage=2011&rft.isbn=&rft.btitle=&rft.title=Biomacromolecules&rft.issn=15257797&rft_id=info:doi/10.1021%2Fbm070193j LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Macromolecules; Data processing; Mathematical models; Gravity; Probes; Velocity; Computer applications; Ultracentrifugation; Migration; Molecular weight; Information processing; Sedimentation; Evolution; Entropy DO - http://dx.doi.org/10.1021/bm070193j ER - TY - JOUR T1 - Bacteriophage Mu C protein is a new member of unusual leucine zipper-HTH class of proteins AN - 20002430; 7297176 AB - Transcription activator protein C of bacteriophage Mu activates transcription of the late genes, including mom, during the lytic cycle of the phage. C binding to its site leads to the alteration in DNA topology of the promoter elements resulting in RNA polymerase (RNAP) recruitment. At the next step, the transactivator enhances promoter clearance of RNAP from P sub(mom). The C protein binds DNA with a very high affinity using a carboxyl-terminal helix turn helix (HTH) motif which has similarity with the HTH from paired domain of Drosophila prd protein. Previous studies established that the protein is dimeric in free and DNA bound forms. We describe now the unique dimerization interface of the protein. Two heptad repeats of hydrophobic amino acids found in the protein were considered to be the candidates for dimerization region. Site-directed mutational analysis revealed that the amino-terminal coiled coil region is not the dimerization determinant. In contrast, similar mutagenesis studies indicated a role for the leucine zipper motif, located in the middle region of the protein, in dimerization. Mixed oligomerization assays confirmed the importance of leucine zipper in C dimer formation establishing the presence of an uncommon zipper-HTH domain in the transactivator. JF - Protein Engineering Design and Selection AU - Chakraborty, Atanu AU - Paul, Bindu Diana AU - Nagaraja, Valakunja AD - Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560 012, India. Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560 064, India Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1 EP - 5 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 20 IS - 1 SN - 1741-0126, 1741-0126 KW - Entomology Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology KW - Phages KW - Bacteria KW - Amino acids KW - protein C KW - Protein engineering KW - Oligomerization KW - Recruitment KW - Hydrophobicity KW - Mutagenesis KW - Promoters KW - DNA-directed RNA polymerase KW - Transcription factors KW - DNA KW - Leucine KW - C protein KW - double prime C protein KW - Leucine zipper proteins KW - Drosophila KW - W 30925:Genetic Engineering KW - Z 05300:General KW - J 02430:Symbiosis, Antibiosis & Phages KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20002430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Engineering+Design+and+Selection&rft.atitle=Bacteriophage+Mu+C+protein+is+a+new+member+of+unusual+leucine+zipper-HTH+class+of+proteins&rft.au=Chakraborty%2C+Atanu%3BPaul%2C+Bindu+Diana%3BNagaraja%2C+Valakunja&rft.aulast=Chakraborty&rft.aufirst=Atanu&rft.date=2007-01-01&rft.volume=20&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Protein+Engineering+Design+and+Selection&rft.issn=17410126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Amino acids; Protein engineering; protein C; Recruitment; Oligomerization; Hydrophobicity; Mutagenesis; Promoters; DNA-directed RNA polymerase; Transcription factors; DNA; double prime C protein; C protein; Leucine; Leucine zipper proteins; Bacteria; Drosophila ER - TY - JOUR T1 - Biosynthesis of Selenocysteine on Its tRNA in Eukaryotes AN - 20001942; 7261451 AB - Selenocysteine (Sec) is cotranslationally inserted into protein in response to UGA codons and is the 21st amino acid in the genetic code. However, the means by which Sec is synthesized in eukaryotes is not known. Herein, comparative genomics and experimental analyses revealed that the mammalian Sec synthase (SecS) is the previously identified pyridoxal phosphate-containing protein known as the soluble liver antigen. SecS required selenophosphate and O-phosphoseryl- tRNA super([Ser]Sec) as substrates to generate selenocysteyl-tRNA super([Ser]Sec). Moreover, it was found that Sec was synthesized on the tRNA scaffold from selenide, ATP, and serine using tRNA super([Ser]Sec), seryl-tRNA synthetase, O- phosphoseryl-tRNA super([Ser]Sec) kinase, selenophosphate synthetase, and SecS. By identifying the pathway of Sec biosynthesis in mammals, this study not only functionally characterized SecS but also assigned the function of the O- phosphoseryl-tRNA super([Ser]Sec) kinase. In addition, we found that selenophosphate synthetase 2 could synthesize monoselenophosphate in vitro but selenophosphate synthetase 1 could not. Conservation of the overall pathway of Sec biosynthesis suggests that this pathway is also active in other eukaryotes and archaea that synthesize selenoproteins. JF - PLoS Biology AU - Xu, Xue-Ming AU - Carlson, Bradley A AU - Mix, Heiko AU - Zhang, Yan AU - Saira, Kazima AU - Glass, Richard S AU - Berry, Marla J AU - Gladyshev, Vadim N AU - Hatfield, Dolph L AD - Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America Y1 - 2007 PY - 2007 DA - 2007 PB - Public Library of Science, 185 Berry Street Suite 1300 San Francisco CA 94107 USA, [mailto:plos@plos.org], [URL:http://www.plos.org] VL - 5 IS - 1 SN - 1544-9173, 1544-9173 KW - Sustainability Science Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - mammals KW - Biosynthesis KW - tRNA Sec KW - Amino acids KW - selenoproteins KW - Archaea KW - tRNA KW - selenophosphate KW - Selenocysteine KW - ATP KW - Serine-tRNA ligase KW - scaffolds KW - Liver KW - Codons KW - Proteins KW - Conservation KW - selenide KW - selenophosphate synthetase 2 KW - genomics KW - Serine KW - Genetic code KW - M3 1010:Issues in Sustainable Development KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20001942?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=PLoS+Biology&rft.atitle=Biosynthesis+of+Selenocysteine+on+Its+tRNA+in+Eukaryotes&rft.au=Xu%2C+Xue-Ming%3BCarlson%2C+Bradley+A%3BMix%2C+Heiko%3BZhang%2C+Yan%3BSaira%2C+Kazima%3BGlass%2C+Richard+S%3BBerry%2C+Marla+J%3BGladyshev%2C+Vadim+N%3BHatfield%2C+Dolph+L&rft.aulast=Xu&rft.aufirst=Xue-Ming&rft.date=2007-01-01&rft.volume=5&rft.issue=1&rft.spage=&rft.isbn=&rft.btitle=&rft.title=PLoS+Biology&rft.issn=15449173&rft_id=info:doi/10.1371%2Fjournal.pbio.0050004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - tRNA Sec; selenoproteins; Amino acids; tRNA; selenophosphate; Selenocysteine; ATP; Serine-tRNA ligase; scaffolds; Codons; Liver; selenophosphate synthetase 2; selenide; genomics; Serine; Genetic code; mammals; Biosynthesis; Conservation; Proteins; Archaea DO - http://dx.doi.org/10.1371/journal.pbio.0050004 ER - TY - JOUR T1 - The triphosphate of beta -d-4-C-ethynyl-2,3-dideoxycytidine is the preferred enantiomer substrate for HIV reverse transcriptase AN - 19997915; 7140148 AB - The enantioselective synthesis of the beta -d (1) enantiomer of 4-C- ethynyl-2,3-dideoxycytidine confirms an earlier stereochemical assignment that was strictly based on the ability of HIV reverse transcriptase and its M184V mutant to discriminate between the d- and l-configuration of nucleoside 5- triphosphates. JF - Bioorganic and Medicinal Chemistry AU - Siddiqui, Maqbool A AU - Marquez, Victor E AD - Laboratory of Medicinal Chemistry, Center for Cancer Research, NCI- Frederick, NIH, Frederick, MD 21702, USA, marquezv@dc37a.nci.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 283 EP - 287 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 15 IS - 1 SN - 0968-0896, 0968-0896 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - 4-C-ethynyldideoxynucleosides KW - Enantioselective synthesis KW - HIV reverse transcriptase KW - Enantiomers KW - Human immunodeficiency virus KW - nucleosides KW - RNA-directed DNA polymerase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19997915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=The+triphosphate+of+beta+-d-4-C-ethynyl-2%2C3-dideoxycytidine+is+the+preferred+enantiomer+substrate+for+HIV+reverse+transcriptase&rft.au=Siddiqui%2C+Maqbool+A%3BMarquez%2C+Victor+E&rft.aulast=Siddiqui&rft.aufirst=Maqbool&rft.date=2007-01-01&rft.volume=15&rft.issue=1&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.09.061 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Enantiomers; nucleosides; RNA-directed DNA polymerase; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.bmc.2006.09.061 ER - TY - JOUR T1 - Multimodal Nanoprobes for Radionuclide and Five-Color Near-Infrared Optical Lymphatic Imaging AN - 19992848; 8019273 AB - Current contrast agents generally have one function and can only be imaged in monochrome; therefore, the majority of imaging methods can only impart uniparametric information. A single nanoparticle has the potential to be loaded with multiple payloads. Such multimodality probes have the ability to be imaged by more than one imaging technique, which could compensate for the weakness or even combine the advantages of each individual modality. Furthermore, optical imaging using different optical probes enables us to achieve multicolor in vivo imaging, wherein multiple parameters can be read from a single image. To allow differentiation of multiple optical signals in vivo, each probe should have a close but different near-infrared emission. To this end, we synthesized nanoprobes with multimodal and multicolor potential, which employed a polyamidoamine dendrimer platform linked to both radionuclides and optical probes, permitting dual-modality scintigraphic and five-color near-infrared optical lymphatic imaging using a multiple- excitation spectrally resolved fluorescence imaging technique. JF - ACS Nano AU - Kobayashi, Hisataka AU - Koyama, Yoshinori AU - Barrett, Tristan AU - Hama, Yukihiro AU - Regino, Celeste AU - Shin, In AU - Jang, Beom-Su AU - Le, Nhat AU - Paik, Chang AU - Choyke, Peter AU - Urano, Yasuteru AD - Molecular Imaging Program and, Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, Nuclear Medicine Department, Warren Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 258 EP - 264 PB - American Chemical Society, [mailto:service@acs.org] VL - 1 IS - 4 SN - 1936-0851, 1936-0851 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Differentiation KW - Fluorescence KW - I.R. radiation KW - polyamidoamines KW - Radioisotopes KW - Contrast media KW - Probes KW - Fluorescent indicators KW - imaging KW - nanoparticles KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19992848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=ACS+Nano&rft.atitle=Multimodal+Nanoprobes+for+Radionuclide+and+Five-Color+Near-Infrared+Optical+Lymphatic+Imaging&rft.au=Kobayashi%2C+Hisataka%3BKoyama%2C+Yoshinori%3BBarrett%2C+Tristan%3BHama%2C+Yukihiro%3BRegino%2C+Celeste%3BShin%2C+In%3BJang%2C+Beom-Su%3BLe%2C+Nhat%3BPaik%2C+Chang%3BChoyke%2C+Peter%3BUrano%2C+Yasuteru&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2007-01-01&rft.volume=1&rft.issue=4&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=ACS+Nano&rft.issn=19360851&rft_id=info:doi/10.1021%2Fnn700062z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-03-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Differentiation; I.R. radiation; Fluorescence; polyamidoamines; Probes; Contrast media; Radioisotopes; Fluorescent indicators; nanoparticles; imaging DO - http://dx.doi.org/10.1021/nn700062z ER - TY - JOUR T1 - Use of Quantum Dot Luminescent Probes To Achieve Single-Cell Resolution of Human Oral Bacteria in Biofilms AN - 19973948; 7248913 AB - Oral biofilms are multispecies communities, and in their nascent stages of development, numerous bacterial species engage in interspecies interactions. Better insight into the spatial relationship between different species and how species diversity increases over time can guide our understanding of the role of interspecies interactions in the development of the biofilms. Quantum dots (QD) are semiconductor nanocrystals and have emerged as a promising tool for labeling and detection of bacteria. We sought to apply QD-based primary immunofluorescence for labeling of bacterial cells with in vitro and in vivo biofilms and to compare this approach with the fluorophore-based primary immunofluorescence approach we have used previously. To investigate QD-based primary immunofluorescence as the means to detect distinct targets with single-cell resolution, we conjugated polyclonal and monoclonal antibodies to the QD surface. We also conducted simultaneous QD conjugate-based and fluorophore conjugate-based immunofluorescence and showed that these conjugates were complementary tools in immunofluorescence applications. Planktonic and biofilm cells were labeled effectively by considering two factors: the final nanomolar concentration of QD conjugate and the amount of antibody conjugated to the QD, which we define as the degree of labeling. These advances in the application of QD-based immunofluorescence for the study of biofilms in vitro and in vivo will help to define bacterial community architecture and to facilitate investigations of interactions between bacterial species in these communities. JF - Applied and Environmental Microbiology AU - Chalmers, Natalia I AU - Palmer, Robert JJr AU - Du-Thumm, Laurence AU - Sullivan, Richard AU - Shi, Wenyuan AU - Kolenbrander, Paul E AD - Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201. National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 310, Bethesda, Maryland 20892. Colgate-Palmolive Company, Piscataway, New Jersey 08855. Department of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, California 90095. UCLA Molecular Biology Institute, Los Angeles, California 90025 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 630 EP - 636 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 73 IS - 2 SN - 0099-2240, 0099-2240 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Monoclonal antibodies KW - Quantum dots KW - Species diversity KW - Probes KW - Developmental stages KW - Immunofluorescence KW - Biofilms KW - fluorophores KW - J 02350:Immunology KW - W 30900:Methods KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19973948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Applied+and+Environmental+Microbiology&rft.atitle=Use+of+Quantum+Dot+Luminescent+Probes+To+Achieve+Single-Cell+Resolution+of+Human+Oral+Bacteria+in+Biofilms&rft.au=Chalmers%2C+Natalia+I%3BPalmer%2C+Robert+JJr%3BDu-Thumm%2C+Laurence%3BSullivan%2C+Richard%3BShi%2C+Wenyuan%3BKolenbrander%2C+Paul+E&rft.aulast=Chalmers&rft.aufirst=Natalia&rft.date=2007-01-01&rft.volume=73&rft.issue=2&rft.spage=630&rft.isbn=&rft.btitle=&rft.title=Applied+and+Environmental+Microbiology&rft.issn=00992240&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Quantum dots; Monoclonal antibodies; Species diversity; Probes; Developmental stages; fluorophores; Biofilms; Immunofluorescence ER - TY - JOUR T1 - Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts AN - 19876406; 7400045 AB - Telomerase activation is a critical event in cell immortalization, and an increase in human telomerase reverse transcriptase (hTERT) expression is the key step in activating telomerase. The phosphatase and tensin homolog (PTEN) gene encodes a double-specific phosphatase that induces cell cycle arrest, inhibits cell growth, and causes apoptotic cell death. Here, we evaluated a combined PTEN and antisense hTERT gene therapy for experimental glioma in vitro and in vivo. We demonstrated that infection with antisense-hTERT and wild-type-PTEN adenoviruses significantly inhibited human U251 glioma cell proliferation in vitro and glioma growth in a xenograft mouse model. The efficacy of therapy was obviously higher in the tumor xenografts infected with both PTEN and antisense hTERT than in the gliomas infected with either agent alone at the same total viral dose. Consistent with these results, we showed that telomerase activity and hTERT protein levels were markedly reduced in the glioma cells following adenovirus infection. In contrast, the levels of PTEN protein expression were dramatically increased in these cells. Our data indicate that combination treatment with antisense hTERT and wild-type PTEN effectively suppresses the malignant growth of human glioma cells in vitro and in tumor xenografts, suggesting a promising new approach in glioma gene therapy that warrants further investigation. JF - Cellular and Molecular Life Sciences AU - You, Y AU - Geng, X AU - Zhao, P AU - Fu, Z AU - Wang, C AU - Chao, S AU - Liu, N AU - Lu, A AU - Gardner, K AU - Pu, P AU - Kong, C AU - Ge, Y AU - Judge, SIV AU - Li, Q Q AD - Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 (USA), liquenti@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 621 EP - 631 VL - 64 IS - 5 SN - 1420-682X, 1420-682X KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell immortalization KW - Apoptosis KW - Data processing KW - Gene therapy KW - Cell cycle KW - Adenovirus KW - Animal models KW - Tumors KW - telomerase reverse transcriptase KW - PTEN protein KW - Infection KW - Brain tumors KW - Cell death KW - Antisense KW - Glioma cells KW - Xenografts KW - Glioma KW - Cell proliferation KW - W 30905:Medical Applications KW - V 22300:Methods KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19876406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Evaluation+of+combination+gene+therapy+with+PTEN+and+antisense+hTERT+for+malignant+glioma+in+vitro+and+xenografts&rft.au=You%2C+Y%3BGeng%2C+X%3BZhao%2C+P%3BFu%2C+Z%3BWang%2C+C%3BChao%2C+S%3BLiu%2C+N%3BLu%2C+A%3BGardner%2C+K%3BPu%2C+P%3BKong%2C+C%3BGe%2C+Y%3BJudge%2C+SIV%3BLi%2C+Q+Q&rft.aulast=You&rft.aufirst=Y&rft.date=2007-01-01&rft.volume=64&rft.issue=5&rft.spage=621&rft.isbn=&rft.btitle=&rft.title=Cellular+and+Molecular+Life+Sciences&rft.issn=1420682X&rft_id=info:doi/10.1007%2Fs00018-007-6424-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell immortalization; Data processing; Apoptosis; Gene therapy; Cell cycle; Animal models; PTEN protein; telomerase reverse transcriptase; Tumors; Infection; Brain tumors; Antisense; Cell death; Glioma cells; Glioma; Xenografts; Cell proliferation; Adenovirus DO - http://dx.doi.org/10.1007/s00018-007-6424-4 ER - TY - JOUR T1 - Roles of Smad3 in TGF- beta Signaling During Carcinogenesis AN - 19862865; 7551170 AB - Signaling of transforming growth factor beta (TGF- beta ) is mediated through a heteromeric complex of two types of transmembrane receptors and downstream intracellular proteins known as Smads. Alterations of TGF- beta signaling underlie various forms of human cancer and developmental diseases. Human genetic studies have revealed both point mutations and deletions of Smad2 or Smad4 in several types of cancers. However, the role of Smad3 in tumorigenesis is not clear. Recent data indicate that Smad3 also functions as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. In addition, Smad3 is essential for TGF- beta -mediated immune suppression, and it plays an important role in regulating transcriptional responses that are favorable to metastasis. Therefore, through regulating different transcriptional responses, Smad3 functions as both a negative and positive regulator of carcinogenesis depending on cell type and clinical stage of the tumor. JF - Critical Reviews in Eukaryotic Gene Expression AU - Millet, C AU - Zhang, YE AD - Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 2056B, Bethesda, MD 20892-4256, USA, yingz@helix.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 281 EP - 293 VL - 17 IS - 4 SN - 1045-4403, 1045-4403 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Intracellular signalling KW - Tumor suppressor genes KW - Apoptosis KW - Data processing KW - Tumorigenesis KW - Point mutation KW - Smad2 protein KW - Transcription KW - Smad protein KW - Smad4 protein KW - Cancer KW - Gene expression KW - Metastases KW - Carcinogenesis KW - Transforming growth factor- beta KW - Smad3 protein KW - Cell proliferation KW - Signal transduction KW - X 24500:Reviews, Legislation, Book & Conference Notices KW - B 26600:Tyrosine Kinase Activity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19862865?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+Reviews+in+Eukaryotic+Gene+Expression&rft.atitle=Roles+of+Smad3+in+TGF-+beta+Signaling+During+Carcinogenesis&rft.au=Millet%2C+C%3BZhang%2C+YE&rft.aulast=Millet&rft.aufirst=C&rft.date=2007-01-01&rft.volume=17&rft.issue=4&rft.spage=281&rft.isbn=&rft.btitle=&rft.title=Critical+Reviews+in+Eukaryotic+Gene+Expression&rft.issn=10454403&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Tumor suppressor genes; Intracellular signalling; Data processing; Apoptosis; Point mutation; Tumorigenesis; Smad2 protein; Transcription; Smad protein; Smad4 protein; Cancer; Metastases; Gene expression; Smad3 protein; Transforming growth factor- beta; Carcinogenesis; Cell proliferation; Signal transduction ER - TY - JOUR T1 - Exploring SCC-DFTB Paths for Mapping QM/MM Reaction Mechanisms AN - 19859423; 8113741 AB - A new first-order procedure for locating transition structures (TS) that employs hybrid quantum mechanical/molecular mechanical (QM/MM) potentials has been developed. This new technique (RPATh+RESD) combines the replica path method (RPATh) and standard reaction coordinate driving (RCD) techniques in an approach that both efficiently determines reaction barriers and successfully eliminates two key weaknesses of RCD calculations (i.e., hysteresis/discontinuities in the path and the sequential nature of the RCD procedure). In addition, we have extended CHARMM's QM/MM reaction pathway methods, the RPATh and nudged elastic band (NEB) methods, to incorporate SCC- DFTB wave functions. This newly added functionality has been applied to the chorismate mutase-catalyzed interconversion of chorismate to prephenate, which is a key step in the shikimate pathway of bacteria, fungi, and other higher plants. The RPATh+RESD barrier height (DeltaE super(thermod) = 5.7 kcal/mol) is in good agreement with previous results from full-energy surface mapping studies (Zhang, X.; Zhang, X.; Bruice, T. C. Biochemistry 2005, 44, 10443-10448). Full reaction paths were independently mapped with RPATh and NEB methods and showed good agreement with the final transition state from the RPATh+RESD "gold standard" and previous high-level QM/MM transition states (Woodcock, H. L.; Hodoscek, M.; Gilbert, T. B.; Gill, P. M. W.; Schaefer, H. F.; Brooks, B. R. J. Comput. Chem. 2007, 28, 1485- 1502). The SCC-DFTB TS geometry most closely approximates the MP2/6-31+G(d) QM/MM result. However, the barrier height is underestimated and possibly points to an area for improvement in SCC-DFTB parametrization. In addition, the steepest descents (SD) minimizer for the NEB method was modified to uncouple the in-path and off-path degrees of freedom during the minimization, which significantly improved performance. The convergence behavior of the RPATh and NEB was examined for SCC-DFTB wave functions, and it was determined that, in general, both methods converge at about the same rate, although the techniques used for convergence may be different. For instance, RPATh can effectively use the adopted basis Newton-Raphson (ABNR) minimizer, where NEB seems to require a combination of SD and ABNR. JF - Journal of Physical Chemistry A: Molecules, Spectroscopy, Kinetics, Environment and General Theory AU - Woodcock, HLee AU - Hodoscek, Milan AU - Brooks, Bernard R AD - Laboratory of Computational Biology, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 5720 EP - 5728 PB - American Chemical Society, P.O. Box 182426 Columbus OH 43218-2426 USA, [mailto:service@acs.org] VL - 111 IS - 26 SN - 1089-5639, 1089-5639 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts B: Bacteriology KW - Reaction mechanisms KW - Convergence KW - Kinetics KW - Fungi KW - Hybrids KW - Waves KW - Hysteresis KW - Mapping KW - Spectroscopy KW - Gills KW - K 03300:Methods KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19859423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Physical+Chemistry+A%3A+Molecules%2C+Spectroscopy%2C+Kinetics%2C+Environment+and+General+Theory&rft.atitle=Exploring+SCC-DFTB+Paths+for+Mapping+QM%2FMM+Reaction+Mechanisms&rft.au=Woodcock%2C+HLee%3BHodoscek%2C+Milan%3BBrooks%2C+Bernard+R&rft.aulast=Woodcock&rft.aufirst=HLee&rft.date=2007-01-01&rft.volume=111&rft.issue=26&rft.spage=5720&rft.isbn=&rft.btitle=&rft.title=Journal+of+Physical+Chemistry+A%3A+Molecules%2C+Spectroscopy%2C+Kinetics%2C+Environment+and+General+Theory&rft.issn=10895639&rft_id=info:doi/10.1021%2Fjp0714217PII%3AS1089-5639%2807%2901421-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Reaction mechanisms; Convergence; Hybrids; Fungi; Kinetics; Hysteresis; Waves; Mapping; Spectroscopy; Gills DO - http://dx.doi.org/10.1021/jp0714217PII:S1089-5639(07)01421-1 ER - TY - JOUR T1 - Entrez Gene: gene-centered information at NCBI AN - 19852367; 7254413 AB - Entrez Gene (www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene) is NCBI's database for gene-specific information. Entrez Gene includes records from genomes that have been completely sequenced, that have an active research community to contribute gene-specific information or that are scheduled for intense sequence analysis. The content of Entrez Gene represents the result of both curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases and from other databases within NCBI. Records in Entrez Gene are assigned unique, stable and tracked integers as identifiers. The content (nomenclature, map location, gene products and their attributes, markers, phenotypes and links to citations, sequences, variation details, maps, expression, homologs, protein domains and external databases) is provided via interactive browsing through NCBI's Entrez system, via NCBI's Entrez programing utilities (E-Utilities), and for bulk transfer by ftp. JF - Nucleic Acids Research AU - Maglott, Donna AU - Ostell, Jim AU - Pruitt, Kim D AU - Tatusova, Tatiana AD - National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD 20892-6510, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D26 EP - D31 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Databases KW - Integration KW - Data processing KW - Browsing KW - Gene mapping KW - Models KW - N 14845:Miscellaneous KW - G 07870:Mammals KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19852367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Entrez+Gene%3A+gene-centered+information+at+NCBI&rft.au=Maglott%2C+Donna%3BOstell%2C+Jim%3BPruitt%2C+Kim+D%3BTatusova%2C+Tatiana&rft.aulast=Maglott&rft.aufirst=Donna&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D26&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Integration; Databases; Data processing; Browsing; Models; Gene mapping ER - TY - JOUR T1 - RegTransBase-a database of regulatory sequences and interactions in a wide range of prokaryotic genomes AN - 19850378; 7254444 AB - RegTransBase is a manually curated database of regulatory interactions in prokaryotes that captures the knowledge in public scientific literature using a controlled vocabulary. Although several databases describing interactions between regulatory proteins and their binding sites are already being maintained, they either focus mostly on the model organisms Escherichia coli and Bacillus subtilis or are entirely computationally derived. RegTransBase describes a large number of regulatory interactions reported in many organisms and contains the following types of experimental data: the activation or repression of transcription by an identified direct regulator, determining the transcriptional regulatory function of a protein (or RNA) directly binding to DNA (RNA), mapping or prediction of a binding site for a regulatory protein and characterization of regulatory mutations. Currently, RegTransBase content is derived from about 3000 relevant articles describing over 7000 experiments in relation to 128 microbes. It contains data on the regulation of about 7500 genes and evidence for 6500 interactions with 650 regulators. RegTransBase also contains manually created position weight matrices (PWM) that can be used to identify candidate regulatory sites in over 60 species. RegTransBase is available at http://regtransbase.lbl.gov. JF - Nucleic Acids Research AU - Kazakov, Alexei E AU - Cipriano, Michael J AU - Novichkov, Pavel S AU - Minovitsky, Simon AU - Vinogradov, Dmitry V AU - Arkin, Adam AU - Mironov, Andrey A AU - Gelfand, Mikhail S AU - Dubchak, Inna AD - Institute for Information Transmission Problems, RAS. Bolshoi Karetny pereulok 19 Moscow, 127994, Russia. Lawrence Berkeley National Laboratory, 1 Cyclotron Road Berkeley, CA 94720, USA. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA. Howard Hughes Medical Institute 4000 Jones Bridge Road Chevy Chase, MD 20815-6789, USA. Department of Bioengineering, University of California Berkeley, CA, 94710, USA. Virtual Institute of Microbial Stress and Survival, Berkeley CA, 94710, USA. Faculty of Bioengineering and Bioinformatics, Moscow State University Vorobievy Gory 1-73, Moscow 119992, Russia. State Research Center GosNIIGenetika. 1-j Dorozhny proezd 1 Moscow, 117545, Russia. Department of Energy Joint Genome Institute 2800 Mitchell Drive,Walnut Creek, CA 94598, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D407 EP - D412 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Bacillus subtilis KW - Data processing KW - Peptide mapping KW - Regulatory sequences KW - Transcription KW - Models KW - Databases KW - regulatory proteins KW - RNA KW - Escherichia coli KW - DNA KW - Prokaryotes KW - Mutation KW - Gene mapping KW - Gene silencing KW - J 02310:Genetics & Taxonomy KW - N 14810:Methods KW - G 07770:Bacteria KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=RegTransBase-a+database+of+regulatory+sequences+and+interactions+in+a+wide+range+of+prokaryotic+genomes&rft.au=Kazakov%2C+Alexei+E%3BCipriano%2C+Michael+J%3BNovichkov%2C+Pavel+S%3BMinovitsky%2C+Simon%3BVinogradov%2C+Dmitry+V%3BArkin%2C+Adam%3BMironov%2C+Andrey+A%3BGelfand%2C+Mikhail+S%3BDubchak%2C+Inna&rft.aulast=Kazakov&rft.aufirst=Alexei&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D407&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Data processing; Peptide mapping; Regulatory sequences; Transcription; Models; Databases; RNA; regulatory proteins; DNA; Prokaryotes; Mutation; Gene silencing; Gene mapping; Bacillus subtilis; Escherichia coli ER - TY - JOUR T1 - Cleavage of a bacterial autotransporter by an evolutionarily convergent autocatalytic mechanism AN - 19847471; 7385934 AB - Bacterial autotransporters are comprised of an N-terminal 'passenger domain' and a C-terminal [beta] barrel ('[beta] domain') that facilitates transport of the passenger domain across the outer membrane. Following translocation, the passenger domains of some autotransporters are cleaved by an unknown mechanism. Here we show that the passenger domain of the Escherichia coli O157:H7 autotransporter EspP is released in a novel autoproteolytic reaction. After purification, the uncleaved EspP precursor underwent proteolytic processing in vitro. An analysis of protein topology together with mutational studies strongly suggested that the reaction occurs inside the [beta] barrel and revealed that two conserved residues, an aspartate within the [beta] domain (Asp super(1120)) and an asparagine (Asn super(1023)) at the P1 position of the cleavage junction, are essential for passenger domain cleavage. Interestingly, these residues were also essential for the proteolytic processing of two distantly related autotransporters. The data strongly suggest that Asp super(1120) and Asn super(1023) form an unusual catalytic dyad that mediates self-cleavage through the cyclization of the asparagine. Remarkably, a very similar mechanism has been proposed for the maturation of eukaryotic viral capsids. JF - EMBO Journal AU - Dautin, Nathalie AU - Barnard, Travis J AU - Anderson, D Eric AU - Bernstein, Harris D AD - Genetics and Biochemistry Branch, National Institutes of Health, Bethesda, MD, USA, harris_bernstein@nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1942 EP - 1952 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 7 SN - 0261-4189, 0261-4189 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - autotransporters KW - enzyme mechanism KW - E. coli KW - protease KW - secretion KW - Proteolysis KW - Capsids KW - Data processing KW - Outer membranes KW - Escherichia coli KW - Asparagine KW - Translocation KW - Evolution KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - V 22320:Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847471?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=EMBO+Journal&rft.atitle=Cleavage+of+a+bacterial+autotransporter+by+an+evolutionarily+convergent+autocatalytic+mechanism&rft.au=Dautin%2C+Nathalie%3BBarnard%2C+Travis+J%3BAnderson%2C+D+Eric%3BBernstein%2C+Harris+D&rft.aulast=Dautin&rft.aufirst=Nathalie&rft.date=2007-01-01&rft.volume=26&rft.issue=7&rft.spage=1942&rft.isbn=&rft.btitle=&rft.title=EMBO+Journal&rft.issn=02614189&rft_id=info:doi/10.1038%2Fsj.emboj.7601638 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Capsids; Proteolysis; Data processing; Outer membranes; Translocation; Asparagine; Evolution; Escherichia coli DO - http://dx.doi.org/10.1038/sj.emboj.7601638 ER - TY - JOUR T1 - Development of leiomyosarcoma of the uterus in MMTV-CR-1 transgenic mice AN - 19846473; 7185744 AB - Overexpression of Cripto-1 (CR-1) in FVB/N mice using the MMTV-LTR promoter results in increased mammary tumourigenesis in these female transgenic mice (MMTV-CR-1). Here, we characterize uterine tumours that developed in 15/76 (19.7%) of MMTV-CR-1 female nulliparous or multiparous mice during 24 months of observation compared with 0/33 (0%) of FVB/N normal control mice observed during the same time period (p < 0.01). The uterine tumours collected from the MMTV-CR-1 mice were classified as leiomyosarcomas and found to express the CR-1 transgene by polymerase chain reaction analysis and immunohistochemistry. Detection by western blot analysis showed higher levels of phosphorylated (P) forms of c-src, Akt, GSK-3 beta , and dephosphorylated (DP)- beta -catenin in lysates from MMTV-CR-1 uterine leiomyosarcomas in comparison with lysates from normal control FVB/N uteri. Immunostaining showed increased nuclear localization of beta - catenin in the MMTV-CR-1 uterine leiomyosarcomas. Increased immunostaining for CR-1 was detected in 9/13 (69.2%) cases of human leiomyosarcoma compared with staining in 3/15 (20%) human leiomyoma sections. Stronger immunostaining for P- src, P-Akt, P-GSK-3 beta and increased nuclear localization of beta -catenin was also seen in human leiomyosarcomas in comparison with leiomyomas. Normal human uterine smooth muscle (UtSM) cells treated with exogenous soluble rhCR-1 showed increased levels of P-src, P-Akt, P-GSK-3 beta and dephosphorylated (DP)- beta -catenin and increased proliferation (p < 0.05) and migration (p < 0.01) in comparison with untreated control UtSM cells. Inhibitors against c-src, Akt or beta -catenin, individually or in combination, significantly reduced CR-1-induced migration. These results suggest a role for CR-1 during uterine tumourigenesis either directly by activating c-src and Akt and/or via cross-talk with the canonical Wnt signalling pathway, as suggested by the increased expression of P- GSK-3 beta , DP- beta -catenin, and increased nuclear localization of beta -catenin in human and MMTV-CR-1 mice leiomyosarcomas. JF - Journal of Pathology AU - Strizzi, L AU - Bianco, C AU - Hirota, M AU - Watanabe, K AU - Mancino, M AU - Hamada, S AU - Raafat, A AU - Lawson, S AU - Ebert, Ad AU - DAntonio, A AU - Losito, S AU - Normanno, N AU - Salomon, Ds AD - Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD, USA, salomond@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 36 EP - 44 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 211 IS - 1 SN - 0022-3417, 0022-3417 KW - Biotechnology and Bioengineering Abstracts KW - Cripto-1 KW - transgenic mice KW - uterus KW - sarcoma KW - Smooth muscle KW - Western blotting KW - Uterus KW - Wnt protein KW - Tumorigenesis KW - Transgenic mice KW - Promoters KW - catenin KW - AKT protein KW - Src protein KW - Polymerase chain reaction KW - Cell migration KW - Cell proliferation KW - Immunohistochemistry KW - Signal transduction KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19846473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pathology&rft.atitle=Development+of+leiomyosarcoma+of+the+uterus+in+MMTV-CR-1+transgenic+mice&rft.au=Strizzi%2C+L%3BBianco%2C+C%3BHirota%2C+M%3BWatanabe%2C+K%3BMancino%2C+M%3BHamada%2C+S%3BRaafat%2C+A%3BLawson%2C+S%3BEbert%2C+Ad%3BDAntonio%2C+A%3BLosito%2C+S%3BNormanno%2C+N%3BSalomon%2C+Ds&rft.aulast=Strizzi&rft.aufirst=L&rft.date=2007-01-01&rft.volume=211&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pathology&rft.issn=00223417&rft_id=info:doi/10.1002%2Fpath.2083 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Western blotting; Uterus; Wnt protein; Tumorigenesis; Transgenic mice; Promoters; catenin; Src protein; AKT protein; Polymerase chain reaction; Cell migration; Cell proliferation; Immunohistochemistry; Signal transduction DO - http://dx.doi.org/10.1002/path.2083 ER - TY - JOUR T1 - Effect of Neutropenia and Treatment Delay on the Response to Antifungal Agents in Experimental Disseminated Candidiasis AN - 19843439; 7205167 AB - Disseminated candidiasis is associated with a high rate of morbidity and mortality. The presence of neutrophils and the timely administration of antifungal agents are likely to be critical factors for a favorable therapeutic outcome of this syndrome. The effect of neutropenia on the temporal profile of the burden of Candida albicans in untreated mice and those treated with amphotericin B was determined using a pharmacodynamic model of disseminated candidiasis. A mathematical model was developed to describe the rate and extent of the C. albicans killing attributable to neutrophils and to amphotericin B. The consequences of a delay in the administration of amphotericin B, flucytosine, or micafungin were studied by defining dose-response relationships. Neutrophils caused a logarithmic decline in fungal burden in treated and untreated mice. The combination of amphotericin B and neutrophils resulted in a high rate of Candida killing and a sustained anti-C. albicans effect. In neutropenic mice, 5 mg/kg of body weight of amphotericin B was required to prevent progressive logarithmic growth. An increased delay in drug administration resulted in a reduction in the maximum effect to a point at which no drug effect could be observed. Neutrophils and the timely initiation of antifungal agents are critical determinants in the treatment of experimental disseminated candidiasis. JF - Antimicrobial Agents & Chemotherapy AU - Hope, William W AU - Drusano, George L AU - Moore, Caroline B AU - Sharp, Andrew AU - Louie, Arnold AU - Walsh, Thomas J AU - Denning, David W AU - Warn, Peter A AD - School of Medicine, 1.800 Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom. Emerging Infections and Host Defense Section, Ordway Research Institute, Albany, New York 12208. Immunocompromised Host Section, Pediatric Oncology Branch, NCI/NIH, Bethesda, Maryland 20892. Wythenshawe Hospital, Manchester M23 9LT, United Kingdom Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 285 EP - 295 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 51 IS - 1 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Mortality KW - Amphotericin B KW - Antifungal agents KW - Mathematical models KW - Candidiasis KW - micafungin KW - Animal models KW - Leukocytes (neutrophilic) KW - Candida albicans KW - flucytosine KW - Morbidity KW - Antimicrobial agents KW - Neutropenia KW - Body weight KW - Dose-response effects KW - Drugs KW - Pharmacodynamics KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Effect+of+Neutropenia+and+Treatment+Delay+on+the+Response+to+Antifungal+Agents+in+Experimental+Disseminated+Candidiasis&rft.au=Hope%2C+William+W%3BDrusano%2C+George+L%3BMoore%2C+Caroline+B%3BSharp%2C+Andrew%3BLouie%2C+Arnold%3BWalsh%2C+Thomas+J%3BDenning%2C+David+W%3BWarn%2C+Peter+A&rft.aulast=Hope&rft.aufirst=William&rft.date=2007-01-01&rft.volume=51&rft.issue=1&rft.spage=285&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amphotericin B; Mortality; Antifungal agents; Mathematical models; Candidiasis; micafungin; Leukocytes (neutrophilic); Animal models; Morbidity; flucytosine; Antimicrobial agents; Neutropenia; Body weight; Dose-response effects; Drugs; Pharmacodynamics; Candida albicans ER - TY - JOUR T1 - Studies of the Biological Properties of Human beta -Defensin 1 AN - 19843429; 7252751 AB - Defensins are small (30-45 amino acid residues) cationic proteins with broad antimicrobial activity against many bacteria and fungi, some enveloped viruses, and other activities such as chemoattraction of a range of different cell types to the sites of inflammation. These proteins represent attractive targets for developing novel antimicrobial agents and modulators of immune responses with therapeutic applicability. In this report, we present the results of functional and structural studies of 26 single-site mutants of human beta -defensin 1 (hBD1). All mutants were assayed for antimicrobial activity against Escherichia coli (ATCC strain 25922) and for chemotactic activity with CCR6-transfected HEK293 cells. To analyze the structural implications of mutagenesis and to verify the correctness of the disulfide connectivity, we used x-ray crystallography to conduct complete structural studies for 10 mutants in which the topology of disulfides was the same as in the native hBD1. Mutations did not induce significant changes of the tertiary structure, suggesting that the observed alterations of biological properties of the mutants were solely associated with changes in the respective side chains. We found that cationic residues located near the C terminus (Arg super(29), Lys super(31), Lys super(33), and Lys super(36)) of hBD1 define most of the anti-E. coli in vitro activity of this protein. In turn, nearly all mutations altering the CCR6-mediated chemotaxis are located at one area of the protein, defined by the N-terminal alpha -helical region (Asp super(1)... Ser super(8)) and a few topologically adjacent residues (Lys super(22), Arg super(29), and Lys super(33)). These experimental results allow for the first time drafting of the CCR6-epitope for a defensin molecule. JF - Journal of Biological Chemistry AU - Pazgier, Marzena AU - Prahl, Adam AU - Hoover, David M AU - Lubkowski, Jacek AD - Macromolecular Crystallography Laboratory, NCI, National Institutes of Health, Frederick, Maryland 21702 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1819 EP - 1829 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 282 IS - 3 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Chemoreception Abstracts; Immunology Abstracts KW - Antimicrobial activity KW - Amino acids KW - Fungi KW - Chemotaxis KW - Antimicrobial agents KW - Mutagenesis KW - Inflammation KW - Protein structure KW - X-ray crystallography KW - Defensins KW - Structure-function relationships KW - Escherichia coli KW - Immune response KW - Tertiary structure KW - Mutation KW - R 18003:Chemotaxis KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19843429?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Studies+of+the+Biological+Properties+of+Human+beta+-Defensin+1&rft.au=Pazgier%2C+Marzena%3BPrahl%2C+Adam%3BHoover%2C+David+M%3BLubkowski%2C+Jacek&rft.aulast=Pazgier&rft.aufirst=Marzena&rft.date=2007-01-01&rft.volume=282&rft.issue=3&rft.spage=1819&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antimicrobial activity; Amino acids; Fungi; Chemotaxis; Inflammation; Mutagenesis; Antimicrobial agents; X-ray crystallography; Protein structure; Defensins; Structure-function relationships; Immune response; Tertiary structure; Mutation; Escherichia coli ER - TY - JOUR T1 - NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins AN - 19841818; 7254489 AB - NCBI's reference sequence (RefSeq) database (http://www.ncbi.nlm.nih.gov/RefSeq/) is a curated non-redundant collection of sequences representing genomes, transcripts and proteins. The database includes 3774 organisms spanning prokaryotes, eukaryotes and viruses, and has records for 2 879 860 proteins (RefSeq release 19). RefSeq records integrate information from multiple sources, when additional data are available from those sources and therefore represent a current description of the sequence and its features. Annotations include coding regions, conserved domains, tRNAs, sequence tagged sites (STS), variation, references, gene and protein product names, and database cross-references. Sequence is reviewed and features are added using a combined approach of collaboration and other input from the scientific community, prediction, propagation from GenBank and curation by NCBI staff. The format of all RefSeq records is validated, and an increasing number of tests are being applied to evaluate the quality of sequence and annotation, especially in the context of complete genomic sequence. JF - Nucleic Acids Research AU - Pruitt, Kim D AU - Tatusova, Tatiana AU - Maglott, Donna R AD - National Center for Biotechnology Information, National Library of Medicine National Institutes of Health Rm 6An.12J, 45 Center Drive, Bethesda, MD 20892-6510, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D61 EP - D65 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Databases KW - Data processing KW - Reviews KW - tRNA KW - Information processing KW - Conserved sequence KW - genomics KW - Prokaryotes KW - G 07880:Human Genetics KW - V 22320:Replication KW - N 14845:Miscellaneous KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19841818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=NCBI+reference+sequences+%28RefSeq%29%3A+a+curated+non-redundant+sequence+database+of+genomes%2C+transcripts+and+proteins&rft.au=Pruitt%2C+Kim+D%3BTatusova%2C+Tatiana%3BMaglott%2C+Donna+R&rft.aulast=Pruitt&rft.aufirst=Kim&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D61&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Genomes; Databases; Data processing; Information processing; tRNA; Reviews; Conserved sequence; Prokaryotes; genomics ER - TY - JOUR T1 - Inhibition of estrogen-independent mammary carcinogenesis by disruption of growth hormone signaling AN - 19840058; 7206697 AB - Clinical trials and laboratory-based studies indicate that the growth hormone/insulin-like growth factor-I axis may affect the development of breast cancer. The purpose of the present investigation was to develop a genetic model of mammary cancer to test the hypothesis that downregulation of GH signaling can substantially retard mammary cancer progression. We crossed the Laron mouse, in which the gene for the GH receptor/binding protein has been disrupted, with the C3(1)/TAg mouse, which develops estrogen receptor alpha negative mammary cancers. All mice used in our experiments were heterozygous for the large T antigen (TAg) and either homozygous wild-type for GHR (Ghr super(+/+)) or null for GHR (Ghr super(-/-)). Compared with the TAg/Ghr super(+/+) mice, the TAg/Ghr super(-/-) mice showed delayed mammary cancer latency with significantly decreased multiplicity (9.8 plus or minus 1.4 versus 3.2 plus or minus 1.2) and volume (776.1 plus or minus 284.4 versus 50.5 plus or minus 8.9 mm super(3)). Furthermore, the frequency of mammary hyperplasias was significantly reduced in the TAg/Ghr super(-/-) mice (15.0 plus or minus 1.7 versus 6.8 plus or minus 1.7). To establish that these mammary cancers were estrogen-independent, 12-week-old TAg/Ghr super(+/+) mice, which lack visible hyperplasia, were either ovariectomized (ovx) or sham operated (sham). Compared with the sham group, ovariectomy resulted in no difference in the frequency of mammary hyperplasia, mammary tumor latency, incidence, multiplicity or tumor size. Together, these data demonstrate that the disruption of GH signaling significantly retards TAg-driven mammary carcinogenesis, and suggest that disrupting GH signaling may be an effective strategy to inhibit the progression of estrogen-independent breast cancer. JF - Carcinogenesis AU - Zhang, Xiao AU - Mehta, Rajendra G AU - Lantvit, Daniel D AU - Coschigano, Karen T AU - Kopchick, John J AU - Green, Jeffrey E AU - Hedayat, Samad AU - Christov, Konstantin T AU - Ray, Vera H AU - Unterman, Terry G AU - Swanson, Steven M AD - Department of Medicinal Chemistry and Pharmacognosy University of Illinois at Chicago, Chicago, IL 60612. Department of Surgical Oncology University of Illinois at Chicago, Chicago, IL 60612. Department of Mathematics, Statistics and Computer Science University of Illinois at Chicago, Chicago, IL 60612. Department of Medicine University of Illinois at Chicago, Chicago, IL 60612. Department of Veterans Affairs Jesse Brown Medical Center, Chicago IL 60612. Illinois Institute of Technology Research Institute, Chicago IL 60616. Edison Biotechnology Institute and Department of Biomedical Sciences, Ohio University Athens, OH. Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute Bethesda, MD. Provident Hospital of Cook County, Chicago IL, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 143 EP - 150 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 1 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Growth hormone KW - Data processing KW - Mammary gland KW - Animal models KW - Tumors KW - Clinical trials KW - Models KW - Hyperplasia KW - Carcinogenesis KW - Breast cancer KW - Ovariectomy KW - Estrogen receptors KW - Signal transduction KW - B 26630:Nuclear & DNA-binding proteins KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19840058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Inhibition+of+estrogen-independent+mammary+carcinogenesis+by+disruption+of+growth+hormone+signaling&rft.au=Zhang%2C+Xiao%3BMehta%2C+Rajendra+G%3BLantvit%2C+Daniel+D%3BCoschigano%2C+Karen+T%3BKopchick%2C+John+J%3BGreen%2C+Jeffrey+E%3BHedayat%2C+Samad%3BChristov%2C+Konstantin+T%3BRay%2C+Vera+H%3BUnterman%2C+Terry+G%3BSwanson%2C+Steven+M&rft.aulast=Zhang&rft.aufirst=Xiao&rft.date=2007-01-01&rft.volume=28&rft.issue=1&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Growth hormone; Data processing; Mammary gland; Animal models; Tumors; Clinical trials; Models; Hyperplasia; Carcinogenesis; Breast cancer; Ovariectomy; Estrogen receptors; Signal transduction ER - TY - JOUR T1 - Applications of Rna Interference in Mammalian Systems AN - 19804738; 8190267 AB - Abstract RNA interference (RNAi) can mediate the long- or short-term silencing of gene expression at the DNA, RNA, and/or protein level. Although several triggers of RNAi have been identified, the best characterized of these are small interfering RNAs (siRNAs), which can decrease gene expression through mRNA transcript cleavage, and endogenous microRNAs (miRNAs), which primarily inhibit protein translation. An improved understanding of RNAi has provided new, powerful tools for conducting functional studies in a gene- specific manner. In various applications, RNAi has been used to create model systems, to identify novel molecular targets, to study gene function in a genome-wide fashion, and to create new avenues for clinical therapeutics. Here, we review many of the ongoing applications of RNAi in mammalian and human systems, and discuss how advances in our knowledge of the RNAi machinery have enhanced the use of these technologies. JF - Annual Review of Genomics & Human Genetics AU - Martin, Scott E AU - Caplen, Natasha J AD - Gene Silencing Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, martinsc@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 81 EP - 108 PB - Annual Reviews, Inc., 4139 El Camino Way Box 10139 Palo Alto CA 94303-0139 USA, [mailto:service@annualreviews.org], [URL:http://annualreviews.org] VL - 8 SN - 1527-8204, 1527-8204 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Translation KW - Molecular modelling KW - siRNA KW - Reviews KW - miRNA KW - DNA KW - RNA-mediated interference KW - Transcription KW - G 07880:Human Genetics KW - W 30940:Products KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19804738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annual+Review+of+Genomics+%26+Human+Genetics&rft.atitle=Applications+of+Rna+Interference+in+Mammalian+Systems&rft.au=Martin%2C+Scott+E%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=81&rft.isbn=&rft.btitle=&rft.title=Annual+Review+of+Genomics+%26+Human+Genetics&rft.issn=15278204&rft_id=info:doi/10.1146%2Fannurev.genom.8.080706.092424 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gene expression; Molecular modelling; Translation; siRNA; Reviews; miRNA; DNA; Transcription; RNA-mediated interference DO - http://dx.doi.org/10.1146/annurev.genom.8.080706.092424 ER - TY - JOUR T1 - A New CYP3A5 Variant, CYP3A5*11, Is Shown to Be Defective in Nifedipine Metabolism in a Recombinant cDNA Expression System AN - 19791585; 7207226 AB - A new CYP3A5 variant, CYP3A5*11, was found in a white European subject by DNA sequencing. The CYP3A5*11 allele contains a single nucleotide polymorphism (SNP) (g.3775A>G) in exon 2, which results in a Tyr53Cys substitution, and a g.6986A>G splice change, the latter SNP previously reported in the defective CYP3A5*3 allele. However, the CYP3A5*3 is not a null allele because this variant is associated with leaky splicing, resulting in small amounts of functional protein still being produced. Therefore, we constructed a cDNA coding for the newly identified CYP3A5.11 protein by site-directed mutagenesis, expressed it in Escherichia coli, and partially purified it. Whereas bacteria transformed with wild-type CYP3A5*1 cDNA expressed predominantly cytochrome P450 (P450), those transfected with CYP3A5*11 expressed a significant amount of denatured cytochrome P420 in addition to P450, suggesting the protein to be unstable. CYP3A5.11 exhibited a 38% decrease in the V sub(max) for nifedipine metabolism, a 2.7-fold increase in the K sub(m), and a 4.4-fold decrease in the CL sub(int) of nifedipine compared with CYP3A5.1. A polymerase chain reaction-restriction fragment length polymorphism genotyping procedure was developed and used to genotype DNA of 500 white individuals for CYP3A5*11. No additional examples of this allele were identified. In summary, individuals carrying the rare CYP3A5*11 allele are predicted to have lower metabolism of CYP3A5 substrates than individuals expressing CYP3A5*3. JF - Drug Metabolism and Disposition AU - Lee, Su-Jun AU - van der Heiden, Ilse P AU - Goldstein, Joyce A AU - van Schaik, Ron HN AD - Human Metabolism Section (S.-J.L., J.A.G.), Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 67 EP - 71 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 35 IS - 1 SN - 0090-9556, 0090-9556 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Site-directed mutagenesis KW - Splicing KW - DNA sequencing KW - Single-nucleotide polymorphism KW - Exons KW - Genotyping KW - Escherichia coli KW - Cytochrome P450 KW - Nifedipine KW - J 02320:Cell Biology KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19791585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=A+New+CYP3A5+Variant%2C+CYP3A5*11%2C+Is+Shown+to+Be+Defective+in+Nifedipine+Metabolism+in+a+Recombinant+cDNA+Expression+System&rft.au=Lee%2C+Su-Jun%3Bvan+der+Heiden%2C+Ilse+P%3BGoldstein%2C+Joyce+A%3Bvan+Schaik%2C+Ron+HN&rft.aulast=Lee&rft.aufirst=Su-Jun&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=67&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-06-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Site-directed mutagenesis; DNA sequencing; Splicing; Exons; Single-nucleotide polymorphism; Genotyping; Cytochrome P450; Nifedipine; Escherichia coli ER - TY - JOUR T1 - A novel superfamily containing the beta -grasp fold involved in binding diverse soluble ligands AN - 19787443; 7280270 AB - Domains containing the beta -grasp fold are utilized in a great diversity of physiological functions but their role, if any, in soluble or small molecule ligand recognition is poorly studied. Results Using sensitive sequence and structure similarity searches we identify a novel superfamily containing the beta - grasp fold. They are found in a diverse set of proteins that include the animal vitamin B12 uptake proteins transcobalamin and intrinsic factor, the bacterial polysaccharide export proteins, the competence DNA receptor ComEA, the cob(I)alamin generating enzyme PduS and the Nqo1 subunit of the respiratory electron transport chain. We present evidence that members of this superfamily are likely to bind a range of soluble ligands, including B12. There are two major clades within this superfamily, namely the transcobalamin-like clade and the Nqo1-like clade. The former clade is typified by an insert of a beta -hairpin after the helix of the beta -grasp fold, whereas the latter clade is characterized by an insert between strands 4 and 5 of the core fold. Conclusion Members of both clades within this superfamily are predicted to interact with ligands in a similar spatial location, with their specific inserts playing a role in the process. Both clades are widely represented in bacteria suggesting that this superfamily was derived early in bacterial evolution. The animal lineage appears to have acquired the transcobalamin-like proteins from low GC Gram-positive bacteria, and this might be correlated with the emergence of the ability to utilize B12 produced by gut bacteria.. JF - Biology Direct AU - Burroughs, A Maxwell AU - Balaji, S AU - Iyer, Lakshminarayan M AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, burrough@ncbi.nlm.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 2 SN - 1745-6150, 1745-6150 KW - Microbiology Abstracts B: Bacteriology KW - Article No. 4 KW - Guanylate cyclase KW - Digestive tract KW - Vitamin B12 KW - Gram-positive bacteria KW - DNA KW - Enzymes KW - NAD(P)H dehydrogenase (quinone) KW - Polysaccharides KW - Evolution KW - Electron transport chain KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787443?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+Direct&rft.atitle=A+novel+superfamily+containing+the+beta+-grasp+fold+involved+in+binding+diverse+soluble+ligands&rft.au=Burroughs%2C+A+Maxwell%3BBalaji%2C+S%3BIyer%2C+Lakshminarayan+M%3BAravind%2C+L&rft.aulast=Burroughs&rft.aufirst=A&rft.date=2007-01-01&rft.volume=2&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Biology+Direct&rft.issn=17456150&rft_id=info:doi/10.1186%2F1745-6150-2-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Guanylate cyclase; Digestive tract; Vitamin B12; Gram-positive bacteria; DNA; Enzymes; NAD(P)H dehydrogenase (quinone); Polysaccharides; Evolution; Electron transport chain DO - http://dx.doi.org/10.1186/1745-6150-2-4 ER - TY - JOUR T1 - Targeted therapy for cancer stem cells: the patched pathway and ABC transporters AN - 19787126; 7260975 AB - Data from certain leukemias as well as brain and breast cancer indicate that there is a small population of tumor cells with 'stem cell' characteristics and the capacity for self-renewal. The self-renewing cells have many of the properties of normal stem cells and have been termed 'cancer stem cells'. These cancer stem cells make up as few as 1% of the cells in a tumor, making them difficult to detect and study. Like normal stem cells, cancer stem cells have a number of properties permitting them to survive traditional cancer chemotherapy and radiation therapy. These cells express high levels of ATP-binding cassette (ABC) drug transporters, providing for a level of resistance; are relatively quiescent; have higher levels of DNA repair and a lowered ability to enter apoptosis. Combined cancer therapy approaches targeting the cancer stem cells and the non-stem cells may be developed with increased efficacy. Efforts to target the Hedgehog/Patched pathway, critical to embryonic growth and differentiation, and the ABCG2 drug efflux transporter will be presented. JF - Oncogene AU - Lou, H AU - Dean, M AD - National Cancer Institute-Frederick, Frederick, MD, USA, dean@ncifcrf.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1357 EP - 1360 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 26 IS - 9 SN - 0950-9232, 0950-9232 KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - cancer stem cell KW - hedgehog/patched pathway KW - smoothened KW - ABC transporters KW - ABCG2 KW - cyclopamine KW - Apoptosis KW - Data processing KW - ABC transporter KW - patched protein KW - Chemotherapy KW - Brain KW - Tumors KW - DNA repair KW - Tumor cells KW - Differentiation KW - Leukemia KW - Stem cells KW - Radiation KW - Breast cancer KW - Embryos KW - Patched protein KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07730:Development & Cell Cycle KW - B 26640:Cell Cycle & DNA Repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19787126?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Targeted+therapy+for+cancer+stem+cells%3A+the+patched+pathway+and+ABC+transporters&rft.au=Lou%2C+H%3BDean%2C+M&rft.aulast=Lou&rft.aufirst=H&rft.date=2007-01-01&rft.volume=26&rft.issue=9&rft.spage=1357&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/10.1038%2Fsj.onc.1210200 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Apoptosis; patched protein; ABC transporter; Chemotherapy; Brain; Tumors; DNA repair; Tumor cells; Leukemia; Differentiation; Stem cells; Radiation; Breast cancer; Embryos; Patched protein DO - http://dx.doi.org/10.1038/sj.onc.1210200 ER - TY - JOUR T1 - A Dominant-Negative Form of the Major Human Abasic Endonuclease Enhances Cellular Sensitivity to Laboratory and Clinical DNA-Damaging Agents AN - 19737317; 7254206 AB - Apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is the primary enzyme in mammals for the repair of abasic sites in DNA, as well as a variety of 3' damages that arise upon oxidation or as products of enzymatic processing. If left unrepaired, APE1 substrates can promote mutagenic and cytotoxic outcomes. We describe herein a dominant-negative form of APE1 that lacks detectable nuclease activity and binds substrate DNA with a 13-fold higher affinity than the wild-type protein. This mutant form of APE1, termed ED, possesses two amino acid substitutions at active site residues Glu super(96) (changed to Gln) and Asp super(210) (changed to Asn). In vitro biochemical assays reveal that ED impedes wild-type APE1 AP site incision function, presumably by binding AP-DNA and blocking normal lesion processing. Moreover, tetracycline-regulated (tet-on) expression of ED in Chinese hamster ovary cells enhances the cytotoxic effects of the laboratory DNA-damaging agents, methyl methanesulfonate (MMS; 5.4-fold) and hydrogen peroxide (1.5-fold). This MMS-induced, ED-dependent cell killing coincides with a hyperaccumulation of AP sites, implying that excessive DNA damage is the cause of cell death. Because an objective of the study was to identify a protein reagent that could be used in targeted gene therapy protocols, the effects of ED on cellular sensitivity to a number of chemotherapeutic compounds was tested. We show herein that ED expression sensitizes Chinese hamster ovary cells to the killing effects of the alkylating agent 1,3-bis(2-chloroethyl)-1-nitrosourea (also known as carmustine) and the chain terminating nucleoside analogue dideoxycytidine (also known as zalcitabine), but not to the radiomimetic bleomycin, the nucleoside analogue {szligbeta}-D-arabinofuranosylcytosine (also known as cytarabine), the topoisomerase inhibitors camptothecin and etoposide, or the cross-linking agents mitomycin C and cisplatin. Transient expression of ED in the human cancer cell line NCI-H1299 enhanced cellular sensitivity to MMS, 1,3-bis(2-chloroethyl)-1-nitrosourea, and dideoxycytidine, demonstrating the potential usefulness of this strategy in the treatment of human tumors. (Mol Cancer Res 2007; 5(1):61-70) JF - Molecular Cancer Research AU - McNeill, Daniel R AU - Wilson, David MIII AD - Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, Maryland Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 61 EP - 70 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 5 IS - 1 SN - 1541-7786, 1541-7786 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Amino acid substitution KW - Nuclease KW - Mitomycin C KW - Tumor cell lines KW - Cisplatin KW - Hydrogen peroxide KW - Endonuclease KW - Etoposide KW - dideoxycytidine KW - Methyl methanesulfonate KW - Alkylating agents KW - cytarabine KW - Gene therapy KW - Zalcitabine KW - Enzymes KW - Tumors KW - Bleomycin KW - Camptothecin KW - Cancer KW - nucleoside analogs KW - DNA damage KW - Cell death KW - Cytotoxicity KW - Oxidation KW - AP endonuclease KW - W 30905:Medical Applications KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19737317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Research&rft.atitle=A+Dominant-Negative+Form+of+the+Major+Human+Abasic+Endonuclease+Enhances+Cellular+Sensitivity+to+Laboratory+and+Clinical+DNA-Damaging+Agents&rft.au=McNeill%2C+Daniel+R%3BWilson%2C+David+MIII&rft.aulast=McNeill&rft.aufirst=Daniel&rft.date=2007-01-01&rft.volume=5&rft.issue=1&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Research&rft.issn=15417786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Amino acid substitution; Nuclease; Mitomycin C; Tumor cell lines; Cisplatin; Hydrogen peroxide; Endonuclease; Etoposide; dideoxycytidine; Alkylating agents; Methyl methanesulfonate; cytarabine; Gene therapy; Zalcitabine; Enzymes; Tumors; Bleomycin; Cancer; Camptothecin; nucleoside analogs; DNA damage; Cytotoxicity; Cell death; Oxidation; AP endonuclease ER - TY - JOUR T1 - Body mass index, physical activity, and dietary behaviors among members of an urban community fitness center: a questionnaire survey AN - 19723280; 9034154 AB - Background Development of effective behavioral interventions to promote weight control and physical activity among diverse, underserved populations is a public health priority. Community focused wellness organizations, such as YMCAs, could provide a unique channel with which to reach such populations. This study assessed health behaviors and related characteristics of members of an urban YMCA facility. Methods We surveyed 135 randomly selected members of an urban YMCA facility in Massachusetts to examine self-reported (1) physical activity, (2) dietary behaviors, (3) body mass index, and (4) correlates of behavior change among short-term (i.e., one year or less) and long-term (i.e., more than one year) members. Chi-square tests were used to assess bivariate associations between variables, and multivariate linear regression models were fit to examine correlates of health behaviors and weight status. Results Eighty-nine percent of short-term and 94% of long-term members reported meeting current physical activity recommendations. Only 24% of short-term and 19% of long-term members met fruit and vegetable consumption recommendations, however, and more than half were overweight or obese. Length of membership was not significantly related to weight status, dietary behaviors, or physical activity. Most respondents were interested in changing health behaviors, in the preparation stage of change, and had high levels of self-efficacy to change behaviors. Short-term members had less education (p = 0.02), lower household incomes (p = 0.02), and were less likely to identify as white (p = 0.005) than long-term members. In multivariate models, females had lower BMI than males (p = 0.003) and reported less physical activity (p = 0.008). Physical activity was also inversely associated with age (p = 0.0004) and education (p = 0.02). Conclusion Rates of overweight/obesity and fruit and vegetable consumption suggested that there is a need for a weight control intervention among members of an urban community YMCA. Membership in such a community wellness facility alone might not be sufficient to help members maintain a healthy weight. The data indicate that YMCA members are interested in making changes in their dietary and physical activity behaviors. Targeting newer YMCA members might be an effective way of reaching underserved populations. These data will help inform the development of a weight control intervention tailored to this setting. JF - BMC Public Health AU - Kaphingst, Kimberly A AU - Bennett, Gary G AU - Sorensen, Glorian AU - Kaphingst, Karen M AU - O'Neil, Amy E AU - McInnis, Kyle AD - Center for Community-Based Research, Dana-Farber Cancer Institute, Boston, MA 02115, USA, kkaphing@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 181 PB - BioMed Central Ltd., Middlesex House VL - 7 SN - 1471-2458, 1471-2458 KW - Physical Education Index UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19723280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Public+Health&rft.atitle=Body+mass+index%2C+physical+activity%2C+and+dietary+behaviors+among+members+of+an+urban+community+fitness+center%3A+a+questionnaire+survey&rft.au=Kaphingst%2C+Kimberly+A%3BBennett%2C+Gary+G%3BSorensen%2C+Glorian%3BKaphingst%2C+Karen+M%3BO%27Neil%2C+Amy+E%3BMcInnis%2C+Kyle&rft.aulast=Kaphingst&rft.aufirst=Kimberly&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=181&rft.isbn=&rft.btitle=&rft.title=BMC+Public+Health&rft.issn=14712458&rft_id=info:doi/10.1186%2F1471-2458-7-181 LA - English DB - Physical Education Index N1 - Date revised - 2009-04-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1471-2458-7-181 ER - TY - JOUR T1 - The two faces of short-range evolutionary dynamics of regulatory modes in bacterial transcriptional regulatory networks AN - 19700283; 7456434 AB - Studies on the conservation of the inferred transcriptional regulatory network of prokaryotes have suggested that specific transcription factors are less-widely conserved in comparison to their target genes. This observation implied that, at large evolutionary distances, the turnover of specific transcription factors through loss and non-orthologous displacement might be a major factor in the adaptive radiation of prokaryotes. However, the recent work of Hershberg and Margalit suggests that, at shorter phylogenetic scales, the evolutionary dynamics of the bacterial transcriptional regulatory network might exhibit distinct patterns. The authors find previously unnoticed relationships between the regulatory mode (activation or repression), the number of regulatory interactions and their conservation patterns in [gamma]- proteobacteria. These relationships might be shaped by the differences in the adaptive value and mode of operation of different regulatory interactions. BioEssays 29:625-629, 2007. JF - Bioessays AU - Balaji, S AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, sbalaji@ncbi.nlm.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 625 EP - 629 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 29 IS - 7 SN - 0265-9247, 0265-9247 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Phylogeny KW - Transcription factors KW - Conservation KW - Prokaryotes KW - Proteobacteria KW - Adaptive radiation KW - Evolution KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19700283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioessays&rft.atitle=The+two+faces+of+short-range+evolutionary+dynamics+of+regulatory+modes+in+bacterial+transcriptional+regulatory+networks&rft.au=Balaji%2C+S%3BAravind%2C+L&rft.aulast=Balaji&rft.aufirst=S&rft.date=2007-01-01&rft.volume=29&rft.issue=7&rft.spage=625&rft.isbn=&rft.btitle=&rft.title=Bioessays&rft.issn=02659247&rft_id=info:doi/10.1002%2Fbies.20600 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Transcription factors; Conservation; Prokaryotes; Evolution; Adaptive radiation; Proteobacteria DO - http://dx.doi.org/10.1002/bies.20600 ER - TY - JOUR T1 - Evidence-based medicine among internal medicine residents in a community AN - 19690961; 7458208 AB - Background: This study implemented and evaluated a point-of-care, wireless JF - BMC Medical Informatics and Decision Making AU - Leon, Sergio A AU - Fontelo, Paul AU - Green, Linda AU - Ackerman, Michael AU - Liu, Fang AD - Office of High Performance Computing and Communications, 8600 Rockville, sleon@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 7 SN - 1472-6947, 1472-6947 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 5 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19690961?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Medical+Informatics+and+Decision+Making&rft.atitle=Evidence-based+medicine+among+internal+medicine+residents+in+a+community&rft.au=Leon%2C+Sergio+A%3BFontelo%2C+Paul%3BGreen%2C+Linda%3BAckerman%2C+Michael%3BLiu%2C+Fang&rft.aulast=Leon&rft.aufirst=Sergio&rft.date=2007-01-01&rft.volume=7&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Medical+Informatics+and+Decision+Making&rft.issn=14726947&rft_id=info:doi/10.1186%2F1472-6947-7-5 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 DO - http://dx.doi.org/10.1186/1472-6947-7-5 ER - TY - JOUR T1 - Transmission-blocking activity induced by malaria vaccine candidates Pfs25/Pvs25 is a direct and predictable function of antibody titer AN - 19675076; 9034713 AB - Background Mosquito stage malaria vaccines are designed to induce an immune response in the human host that will block the parasite's growth in the mosquito and consequently block transmission of the parasite. A mosquito membrane-feeding assay (MFA) is used to test transmission-blocking activity (TBA), but in this technique cannot accommodate many samples. A clear understanding of the relationship between antibody levels and TBA may allow ELISA determinations to be used to predict TBA and assist in planning vaccine development. Methods Rabbit anti-Pfs25 sera and monkey anti-Pvs25 sera were generated and the antibody titers were determined by a standardized ELISA. The biological activity of the same sera was tested by MFA using Plasmodium gametocytes (cultured Plasmodium falciparum or Plasmodium vivax from malaria patients) and Anopheles mosquitoes. Results Anti-Pfs25 and anti-Pvs25 sera showed that ELISA antibody units correlate with the percent reduction in the oocyst density per mosquito (Spearman Rank correlations: 0.934 and 0.616, respectively), and fit a hyperbolic curve when percent reduction in oocyst density is plotted against antibody units of the tested sample. Antibody levels also correlated with the number of mosquitoes that failed to become infected, and this proportion can be calculated from the reduction in oocyst numbers and the distribution of oocysts per infected mosquito in control group. Conclusion ELISA data may be used as a surrogate for the MFA to evaluate transmission-blocking vaccine efficacy. This will facilitate the evaluation of transmission-blocking vaccines and implementation of this malaria control strategy. JF - Malaria Journal AU - Miura, Kazutoyo AU - Keister, David B AU - Muratova, Olga V AU - Sattabongkot, Jetsumon AU - Long, Carole A AU - Saul, Allan AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA, kmiura@niaid.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 107 PB - BioMed Central Ltd., Middlesex House VL - 6 SN - 1475-2875, 1475-2875 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Q5 01522:Protective measures and control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19675076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Transmission-blocking+activity+induced+by+malaria+vaccine+candidates+Pfs25%2FPvs25+is+a+direct+and+predictable+function+of+antibody+titer&rft.au=Miura%2C+Kazutoyo%3BKeister%2C+David+B%3BMuratova%2C+Olga+V%3BSattabongkot%2C+Jetsumon%3BLong%2C+Carole+A%3BSaul%2C+Allan&rft.aulast=Miura&rft.aufirst=Kazutoyo&rft.date=2007-01-01&rft.volume=6&rft.issue=&rft.spage=107&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=14752875&rft_id=info:doi/10.1186%2F1475-2875-6-107 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1475-2875-6-107 ER - TY - JOUR T1 - Susceptibility of Anopheles gambiae and Anopheles stephensi to tropical isolates of Plasmodium falciparum AN - 19673470; 9034745 AB - Background The susceptibility of anopheline mosquito species to Plasmodium infection is known to be variable with some mosquitoes more permissive to infection than others. Little work, however, has been carried out investigating the susceptibility of major malaria vectors to geographically diverse tropical isolates of Plasmodium falciparum aside from examining the possibility of infection extending its range from tropical regions into more temperate zones. Methods This study investigates the susceptibility of two major tropical mosquito hosts (Anopheles gambiae and Anopheles stephensi) to P. falciparum isolates of different tropical geographical origins. Cultured parasite isolates were fed via membrane feeders simultaneously to both mosquito species and the resulting mosquito infections were compared. Results Infection prevalence was variable with African parasites equally successful in both mosquito species, Thai parasites significantly more successful in An. stephensi, and PNG parasites largely unsuccessful in both species. Conclusion Infection success of P. falciparum was variable according to geographical origin of both the parasite and the mosquito. Data presented raise the possibility that local adaptation of tropical parasites and mosquitoes has a role to play in limiting gene flow between allopatric parasite populations. JF - Malaria Journal AU - Hume, Jennifer CC AU - Tunnicliff, Mark AU - Ranford-Cartwright, Lisa C AU - Day, Karen P AD - Peter Medawar Building for Pathogen Research and Department of Zoology, South Park road, University of Oxford, Oxford OX1 3SY, UK, humej@niaid.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 139 PB - BioMed Central Ltd., Middlesex House VL - 6 SN - 1475-2875, 1475-2875 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Q5 01524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19673470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Susceptibility+of+Anopheles+gambiae+and+Anopheles+stephensi+to+tropical+isolates+of+Plasmodium+falciparum&rft.au=Hume%2C+Jennifer+CC%3BTunnicliff%2C+Mark%3BRanford-Cartwright%2C+Lisa+C%3BDay%2C+Karen+P&rft.aulast=Hume&rft.aufirst=Jennifer&rft.date=2007-01-01&rft.volume=6&rft.issue=&rft.spage=139&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=14752875&rft_id=info:doi/10.1186%2F1475-2875-6-139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1475-2875-6-139 ER - TY - JOUR T1 - Standardizing estimates of the Plasmodium falciparum parasite rate AN - 19670708; 9034737 AB - Background The Plasmodium falciparum parasite rate (PfPR) is a commonly reported index of malaria transmission intensity. PfPR rises after birth to a plateau before declining in older children and adults. Studies of populations with different age ranges generally report average PfPR, so age is an important source of heterogeneity in reported PfPR data. This confounds simple comparisons of PfPR surveys conducted at different times or places. Methods Several algorithms for standardizing PfPR were developed using 21 studies that stratify in detail PfPR by age. An additional 121 studies were found that recorded PfPR from the same population over at least two different age ranges; these paired estimates were used to evaluate these algorithms. The best algorithm was judged to be the one that described most of the variance when converting the PfPR pairs from one age-range to another. Results The analysis suggests that the relationship between PfPR and age is predictable across the observed range of malaria endemicity. PfPR reaches a peak after about two years and remains fairly constant in older children until age ten before declining throughout adolescence and adulthood. The PfPR pairs were poorly correlated; using one to predict the other would explain only 5% of the total variance. By contrast, the PfPR predicted by the best algorithm explained 72% of the variance. Conclusion The PfPR in older children is useful for standardization because it has good biological, epidemiological and statistical properties. It is also historically consistent with the classical categories of hypoendemic, mesoendemic and hyperendemic malaria. This algorithm provides a reliable method for standardizing PfPR for the purposes of comparing studies and mapping malaria endemicity. The scripts for doing so are freely available to all. JF - Malaria Journal AU - Smith, David L AU - Guerra, Carlos A AU - Snow, Robert W AU - Hay, Simon I AD - Fogarty International Center, National Institutes of Health, Building 16, 16 Center Drive, Bethesda, Maryland 20892, USA, davesmith@ufl.edu Y1 - 2007 PY - 2007 DA - 2007 SP - 131 PB - BioMed Central Ltd., Middlesex House VL - 6 SN - 1475-2875, 1475-2875 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Q5 01524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19670708?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Malaria+Journal&rft.atitle=Standardizing+estimates+of+the+Plasmodium+falciparum+parasite+rate&rft.au=Smith%2C+David+L%3BGuerra%2C+Carlos+A%3BSnow%2C+Robert+W%3BHay%2C+Simon+I&rft.aulast=Smith&rft.aufirst=David&rft.date=2007-01-01&rft.volume=6&rft.issue=&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Malaria+Journal&rft.issn=14752875&rft_id=info:doi/10.1186%2F1475-2875-6-131 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-03-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1186/1475-2875-6-131 ER - TY - JOUR T1 - Employer and Healthcare Policy Interventions Aimed at Adult Obesity AN - 19656911; 8791199 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Fuemmeler, Bernard F AU - Baffi, Charlie AU - Masse, Louise C AU - Atienza, Audie A AU - Evans, W Doug AD - National Cancer Institute, Bethesda, Maryland, bernard.fuemmeler@duke.edu Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 44 EP - 51 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 32 IS - 1 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Obesity KW - Employers KW - Policy KW - Adults KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19656911?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Employer+and+Healthcare+Policy+Interventions+Aimed+at+Adult+Obesity&rft.au=Fuemmeler%2C+Bernard+F%3BBaffi%2C+Charlie%3BMasse%2C+Louise+C%3BAtienza%2C+Audie+A%3BEvans%2C+W+Doug&rft.aulast=Fuemmeler&rft.aufirst=Bernard&rft.date=2007-01-01&rft.volume=32&rft.issue=1&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2006.09.003 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Adults; Obesity; Employers; Policy DO - http://dx.doi.org/10.1016/j.amepre.2006.09.003 ER - TY - JOUR T1 - Comparing Genetically Engineered Mouse Mammary Cancer Models with Human Breast Cancer by Expression Profiling AN - 19618093; 8717186 AB - Breast cancer is a heterogeneous disease, and much of the molecular basis for this heterogeneity is being unraveled using advanced genomic technologies. More recently, global transcriptional profiling has proven to be an effective new tool for characterizing human tumors. Genomic ``signatures'' have been developed that classify tumors with varying prognoses and responses to treatment. Recent studies have begun to extend the use of global transcriptional profiling to better characterize genetically engineered mouse (GEM) models of breast cancer, which will improve the ability to translate basic research advances into clinical advances. GEM models of mammary carcinoma have proven to be invaluable tools to gain insight into mechanisms underlying tumor initiation, progression, and therapeutic responses in an in vivo system where tumors spontaneously develop in an appropriate tissue environment. This review will discuss the use of transcriptional profiling of breast cancer in tumors from both human patients and GEM models to improve prognostic measures, examine mechanisms of tumor initiation and progression, identify novel therapeutic targets, and improve pre-clinical testing for drug development. Together, these advances offer a framework for classifying human tumors, identifying appropriate GEM models for specific experimental purposes, and utilizing the combined data to identify more specific and effective cancer therapies. JF - Breast Disease AU - Shoushtari, Alexander N AU - Michalowska, Aleksandra M AU - Green, Jeffrey E AD - Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 39 EP - 51 PB - IOS Press, Nieuwe Hemweg 6B VL - 28 SN - 0888-6008, 0888-6008 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Mammary gland KW - Genetic engineering KW - Animal models KW - Breast cancer KW - Transcription KW - Drug development KW - Tumors KW - genomics KW - Models KW - Carcinoma KW - W 30925:Genetic Engineering KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19618093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Breast+Disease&rft.atitle=Comparing+Genetically+Engineered+Mouse+Mammary+Cancer+Models+with+Human+Breast+Cancer+by+Expression+Profiling&rft.au=Shoushtari%2C+Alexander+N%3BMichalowska%2C+Aleksandra+M%3BGreen%2C+Jeffrey+E&rft.aulast=Shoushtari&rft.aufirst=Alexander&rft.date=2007-01-01&rft.volume=28&rft.issue=&rft.spage=39&rft.isbn=&rft.btitle=&rft.title=Breast+Disease&rft.issn=08886008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Data processing; Mammary gland; Genetic engineering; Animal models; Transcription; Breast cancer; Drug development; genomics; Tumors; Carcinoma; Models ER - TY - JOUR T1 - SpliceMiner: a high-throughput database implementation of the NCBI Evidence Viewer for microarray splice variant analysis AN - 19612553; 7332965 AB - There are many fewer genes in the human genome than there are expressed transcripts. Alternative splicing is the reason. Alternatively spliced transcripts are often specific to tissue type, developmental stage, environmental condition, or disease state. Accurate analysis of microarray expression data and design of new arrays for alternative splicing require assessment of probes at the sequence and exon levels. Description SpliceMiner is a web interface for querying Evidence Viewer Database (EVDB). EVDB is a comprehensive, non-redundant compendium of splice variant data for human genes. We constructed EVDB as a queryable implementation of the NCBI Evidence Viewer (EV). EVDB is based on data obtained from NCBI Entrez Gene and EV. The automated EVDB build process uses only complete coding sequences, which may or may not include partial or complete 5' and 3' UTRs, and filters redundant splice variants. Unlike EV, which supports only one-at-a-time queries, SpliceMiner supports high-throughput batch queries and provides results in an easily parsable format. SpliceMiner maps probes to splice variants, effectively delineating the variants identified by a probe. Conclusion EVDB can be queried by gene symbol, genomic coordinates, or probe sequence via a user-friendly web-based tool we call SpliceMiner ( JF - BMC Bioinformatics AU - Kahn, Ari B AU - Ryan, Michael C AU - Liu, Hongfang AU - Zeeberg, Barry R AU - Jamison, D Curtis AU - Weinstein, John N AD - Department of Bioinformatics, George Mason University, Fairfax, Virginia, USA, arik@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 8 SN - 1471-2105, 1471-2105 KW - Biotechnology and Bioengineering Abstracts KW - Article No. 75 KW - Genomes KW - Exons KW - DNA probes KW - Developmental stages KW - DNA microarrays KW - Alternative splicing KW - Filters KW - Databases KW - Bioinformatics KW - genomics KW - Environmental conditions KW - Gene mapping KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19612553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Bioinformatics&rft.atitle=SpliceMiner%3A+a+high-throughput+database+implementation+of+the+NCBI+Evidence+Viewer+for+microarray+splice+variant+analysis&rft.au=Kahn%2C+Ari+B%3BRyan%2C+Michael+C%3BLiu%2C+Hongfang%3BZeeberg%2C+Barry+R%3BJamison%2C+D+Curtis%3BWeinstein%2C+John+N&rft.aulast=Kahn&rft.aufirst=Ari&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Bioinformatics&rft.issn=14712105&rft_id=info:doi/10.1186%2F1471-2105-8-75 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Filters; Genomes; Databases; Exons; DNA probes; Developmental stages; genomics; Bioinformatics; Environmental conditions; DNA microarrays; Gene mapping; Alternative splicing DO - http://dx.doi.org/10.1186/1471-2105-8-75 ER - TY - JOUR T1 - Parent involvement in novice teen driving: Rationale, evidence of effects, and potential for enhancing graduated driver licensing effectiveness AN - 19580364; 8549553 AB - Motor-vehicle crash rates are highly elevated immediately after licensure and then decline gradually over a period of years. Young age, risk taking, and inexperience contribute to the problem, but inexperience is particularly important early on. Driving is like other complex, skilled behaviors in which subtle improvements in perception and judgment develop gradually over a period of years. After all, safe driving is more a matter of attention and perception than physical management of the vehicle. Inexperience is particularly linked to driving performance and safety outcomes under certain driving conditions, with driving at night and with teen passengers as the most important cases. Surprisingly, driving outcomes do not appear to be affected by the pre-license training or supervised practice driving. Given the limits of training, safety effects can best be achieved by countermeasures that delay licensure or limit novice teen driving under high risk driving conditions while novices gain experience and develop safety competence. The two complementary approaches of Graduated Driver Licensing policies and parent management have been shown to provide safety effects by limiting the driving conditions of novice teenagers. JF - Journal of Safety Research AU - Simons-Morton, Bruce AD - Prevention Research Branch, Division of Epidemiology, Statistics, and Prevention Research; National Institute of Child Health and Human Development, 6100 Executive Blvd, 7B05, Bethesda, MD, 20892-7510, USA, mortonb@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 193 EP - 202 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 38 IS - 2 SN - 0022-4375, 0022-4375 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - Accidents KW - Driving ability KW - risk taking KW - graduated licensing KW - Adolescents KW - Training KW - Perception KW - Traffic safety KW - H 2000:Transportation KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19580364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Safety+Research&rft.atitle=Parent+involvement+in+novice+teen+driving%3A+Rationale%2C+evidence+of+effects%2C+and+potential+for+enhancing+graduated+driver+licensing+effectiveness&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2007-01-01&rft.volume=38&rft.issue=2&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Journal+of+Safety+Research&rft.issn=00224375&rft_id=info:doi/10.1016%2Fj.jsr.2007.02.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Training; graduated licensing; Perception; Accidents; Adolescents; risk taking; Traffic safety; Driving ability; Age DO - http://dx.doi.org/10.1016/j.jsr.2007.02.007 ER - TY - JOUR T1 - 3,4-Methylenedioxymethamphetamine (MDMA) neurotoxicity in rats: a reappraisal of past and present findings AN - 19579819; 7300498 AB - Rationale: 3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug. In animals, high-dose administration of MDMA produces deficits in serotonin (5-HT) neurons (e.g., depletion of forebrain 5-HT) that have been interpreted as neurotoxicity. Whether such 5-HT deficits reflect neuronal damage is a matter of ongoing debate. Objective: The present paper reviews four specific issues related to the hypothesis of MDMA neurotoxicity in rats: (1) the effects of MDMA on monoamine neurons, (2) the use of 'interspecies scaling' to adjust MDMA doses across species, (3) the effects of MDMA on established markers of neuronal damage, and (4) functional impairments associated with MDMA-induced 5-HT depletions. Results: MDMA is a substrate for monoamine transporters, and stimulated release of 5-HT, NE, and DA mediates effects of the drug. MDMA produces neurochemical, endocrine, and behavioral actions in rats and humans at equivalent doses (e.g., 1-2 mg/kg), suggesting that there is no reason to adjust doses between these species. Typical doses of MDMA causing long-term 5-HT depletions in rats (e.g., 10-20 mg/kg) do not reliably increase markers of neurotoxic damage such as cell death, silver staining, or reactive gliosis. MDMA-induced 5-HT depletions are accompanied by a number of functional consequences including reductions in evoked 5-HT release and changes in hormone secretion. Perhaps more importantly, administration of MDMA to rats induces persistent anxiety-like behaviors in the absence of measurable 5-HT deficits. Conclusions: MDMA-induced 5-HT depletions are not necessarily synonymous with neurotoxic damage. However, doses of MDMA which do not cause long-term 5-HT depletions can have protracted effects on behavior, suggesting even moderate doses of the drug may pose risks. JF - Psychopharmacology AU - Baumann, Michael H AU - Wang, Xiaoying AU - Rothman, Richard B AD - Clinical Psychopharmacology Section, Intramural Research Program (IRP), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), 5500 Nathan Shock Drive, Baltimore, MD, 21224, USA, mbaumann@intra.nida.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 407 EP - 424 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 189 IS - 4 SN - 0033-3158, 0033-3158 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - monoamines KW - Anxiety KW - Monoamine transporter KW - Drug abuse KW - Hormones KW - MDMA KW - Serotonin KW - Forebrain KW - Cell death KW - Reviews KW - Neurons KW - Neurotoxicity KW - gliosis KW - Scaling KW - X 24380:Social Poisons & Drug Abuse KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19579819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=3%2C4-Methylenedioxymethamphetamine+%28MDMA%29+neurotoxicity+in+rats%3A+a+reappraisal+of+past+and+present+findings&rft.au=Baumann%2C+Michael+H%3BWang%2C+Xiaoying%3BRothman%2C+Richard+B&rft.aulast=Baumann&rft.aufirst=Michael&rft.date=2007-01-01&rft.volume=189&rft.issue=4&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/10.1007%2Fs00213-006-0322-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - monoamines; Anxiety; Monoamine transporter; Drug abuse; MDMA; Hormones; Serotonin; Forebrain; Cell death; Neurons; Reviews; Neurotoxicity; gliosis; Scaling DO - http://dx.doi.org/10.1007/s00213-006-0322-6 ER - TY - JOUR T1 - Tryptophanase in sRNA control of the Escherichia coli cell cycle AN - 19563469; 7228977 AB - The field of gene regulation underwent a major revolution with the discovery of small non-coding RNAs (sRNAs) and the various roles they play in organisms from bacteria to man. Escherichia coli has more than 60 sRNAs that are transcribed primarily from intergenic regions. They usually target the leader region of mRNAs and prevent their translation. Protein targets are relatively rare. In this issue of Molecular Microbiology, Chant and Summers provide an example of a totally unexpected protein target. They show that dimers of plasmid ColE1 make an sRNA that interacts directly with the enzyme tryptophanase and enhances its affinity for its substrate, tryptophan. A breakdown product, indole, then arrests cell division until the dimers are resolved to monomers. The monomerization helps to prevent plasmid loss. Targeting a catabolic enzyme to buy time for recombination is an amazing example of adaptation, which illustrates the power of a selfish element (a plasmid in this case) to exploit the host cell machinery to its advantage. JF - Molecular Microbiology AU - Chattoraj, Dhruba K Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1 EP - 3 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 63 IS - 1 SN - 0950-382X, 0950-382X KW - Genetics Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - Tryptophan KW - Translation KW - Adaptations KW - Cell cycle KW - non-coding RNA KW - Enzymes KW - Plasmids KW - Monomers KW - Recombination KW - Cell division KW - Indole KW - Gene regulation KW - Reviews KW - Escherichia coli KW - Tryptophan 2,3-dioxygenase KW - J 02320:Cell Biology KW - N 14830:RNA KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19563469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Tryptophanase+in+sRNA+control+of+the+Escherichia+coli+cell+cycle&rft.au=Chattoraj%2C+Dhruba+K&rft.aulast=Chattoraj&rft.aufirst=Dhruba&rft.date=2007-01-01&rft.volume=63&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05517.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 1; references, 15. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Translation; Tryptophan; Adaptations; Cell cycle; non-coding RNA; Enzymes; Plasmids; Monomers; Recombination; Cell division; Indole; Reviews; Gene regulation; Tryptophan 2,3-dioxygenase; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05517.x ER - TY - JOUR T1 - research paper: Severity of pulmonary hypertension during vaso-occlusive pain crisis and exercise in patients with sickle cell disease AN - 19561280; 7225054 AB - Pulmonary hypertension is associated with sudden death and is a risk factor for mortality in adult patients with sickle cell disease. The high mortality despite only mild-to-moderate increases in pulmonary vascular resistance remains an unresolved paradox. Accordingly, little is known about the cardiovascular effects of stressors, such as vaso-occlusive pain crisis (VOC) and exercise, which may acutely increase pulmonary pressures and impair right heart function. We therefore evaluated pulmonary artery pressures by echocardiogram in 25 patients with sickle cell disease in steady-state and during VOC, and by right heart catheterisation with exercise in a second cohort of 21 patients to determine whether pulmonary hypertension worsens during acute cardiopulmonary stress. TRV increased during VOC (P < 0.001), and the increased pulmonary pressures during VOC were associated with decreases in haemoglobin levels (P < 0.001), and increases in lactate dehydrogenase (P < 0.001) and plasma haemoglobin levels (P = 0.03). During exercise stress performed during cardiac catheterisation, mean pulmonary artery pressures (P < 0.001) and pulmonary vascular resistance increased (P < 0.001) in all subjects. These data suggest that acute elevations in pulmonary pressures during VOC or exercise may contribute to morbidity and mortality in patients with sickle cell disease. JF - British Journal of Haematology AU - Machado, Roberto F AU - Kyle Mack, A AU - Martyr, Sabrina AU - Barnett, Christopher AU - MacArthur, Peter AU - Sachdev, Vandana AU - Ernst, Inez AU - Hunter, Lori A AU - Coles, Wynona A AU - Nichols, James P AU - Kato, Gregory J AU - Gladwin, Mark T AD - Vascular Medicine Branch, National Heart Lung and Blood Institute Critical Care Medicine Department, Clinical Center Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 319 EP - 325 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 136 IS - 2 SN - 0007-1048, 0007-1048 KW - Physical Education Index KW - Heart KW - Death KW - Exercise physiology KW - Stress KW - Pain KW - Patients KW - Adults KW - Risk factors KW - Lactic acid KW - Cardiorespiratory KW - Diseases KW - Circulatory system KW - Hypertension KW - PE 090:Sports Medicine & Exercise Sport Science UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19561280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Haematology&rft.atitle=research+paper%3A+Severity+of+pulmonary+hypertension+during+vaso-occlusive+pain+crisis+and+exercise+in+patients+with+sickle+cell+disease&rft.au=Machado%2C+Roberto+F%3BKyle+Mack%2C+A%3BMartyr%2C+Sabrina%3BBarnett%2C+Christopher%3BMacArthur%2C+Peter%3BSachdev%2C+Vandana%3BErnst%2C+Inez%3BHunter%2C+Lori+A%3BColes%2C+Wynona+A%3BNichols%2C+James+P%3BKato%2C+Gregory+J%3BGladwin%2C+Mark+T&rft.aulast=Machado&rft.aufirst=Roberto&rft.date=2007-01-01&rft.volume=136&rft.issue=2&rft.spage=319&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Haematology&rft.issn=00071048&rft_id=info:doi/10.1111%2Fj.1365-2141.2006.06417.x LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - SuppNotes - Figures, 2; tables, 1. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Exercise physiology; Death; Stress; Patients; Pain; Adults; Risk factors; Lactic acid; Cardiorespiratory; Diseases; Hypertension; Circulatory system DO - http://dx.doi.org/10.1111/j.1365-2141.2006.06417.x ER - TY - JOUR T1 - An annotated catalogue of salivary gland transcripts in the adult female mosquito, Aedes aegypti* AN - 19557997; 7273819 AB - Saliva of blood-sucking arthropods contains a cocktail of antihemostatic agents and immunomodulators that help blood feeding. Mosquitoes additionally feed on sugar meals and have specialized regions of their glands containing glycosidases and antimicrobials that might help control bacterial growth in the ingested meals. To expand our knowledge on the salivary cocktail of Aedes aegypti, a vector of dengue and yellow fevers, we analyzed a set of 4,232 expressed sequence tags from cDNA libraries of adult female mosquitoes. Results A nonredundant catalogue of 614 transcripts (573 of which are novel) is described, including 136 coding for proteins of a putative secretory nature. Additionally, a two-dimensional gel electrophoresis of salivary gland (SG) homogenates followed by tryptic digestion of selected protein bands and MS/MS analysis revealed the expression of 24 proteins. Analysis of tissue-specific transcription of a subset of these genes revealed at least 31 genes whose expression is specific or enriched in female SG, whereas 24 additional genes were expressed in female SG and in males but not in other female tissues. Most of the 55 proteins coded by these SG transcripts have no known function and represent high-priority candidates for expression and functional analysis as antihemostatic or antimicrobial agents. An unexpected finding is the occurrence of four protein families specific to SG that were probably a product of horizontal transfer from prokaryotic organisms to mosquitoes. Conclusion Overall, this paper contributes to the novel identification of 573 new transcripts, or near 3% of the Ae. aegypti proteome assuming a 20,000- protein set, and to the best-described sialome of any blood-feeding insect. JF - BMC Genomics AU - Ribeiro, Jose MC AU - Arca, Bruno AU - Lombardo, Fabrizio AU - Calvo, Eric AU - Phan, van My AU - Chandra, Prafulla K AU - Wikel, Stephen K AD - Section of Vector Biology, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12735 Twinbrook Parkway, Rockville, Maryland 20852, USA, Jribeiro@niaid.nih.gov Y1 - 2007 PY - 2007 DA - 2007 PB - BioMed Central Ltd., Middlesex House 34-42 Cleveland Street London W1T 4LB UK, [mailto:info@biomedcentral.com], [URL:http://www.biomedcentral.com] VL - 8 SN - 1471-2164, 1471-2164 KW - Yellow fever mosquito KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Genetics Abstracts KW - Article No. 6 KW - Sugar KW - Feeding KW - Aedes aegypti KW - protein families KW - Transcription KW - Salivary gland KW - Immunomodulation KW - expressed sequence tags KW - Horizontal transfer KW - Gel electrophoresis KW - Antimicrobial agents KW - Blood KW - Arthropoda KW - Dengue KW - Yellow fever KW - Saliva KW - G 07810:Insects KW - Z 05360:Genetics and Evolution KW - J 02350:Immunology KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19557997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+Genomics&rft.atitle=An+annotated+catalogue+of+salivary+gland+transcripts+in+the+adult+female+mosquito%2C+Aedes+aegypti*&rft.au=Ribeiro%2C+Jose+MC%3BArca%2C+Bruno%3BLombardo%2C+Fabrizio%3BCalvo%2C+Eric%3BPhan%2C+van+My%3BChandra%2C+Prafulla+K%3BWikel%2C+Stephen+K&rft.aulast=Ribeiro&rft.aufirst=Jose&rft.date=2007-01-01&rft.volume=8&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=BMC+Genomics&rft.issn=14712164&rft_id=info:doi/10.1186%2F1471-2164-8-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Feeding; Sugar; Transcription; protein families; Salivary gland; expressed sequence tags; Immunomodulation; Gel electrophoresis; Horizontal transfer; Antimicrobial agents; Blood; Dengue; Yellow fever; Saliva; Aedes aegypti; Arthropoda DO - http://dx.doi.org/10.1186/1471-2164-8-6 ER - TY - JOUR T1 - Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations AN - 19550260; 7255142 AB - To obtain quantitative information on the size and dynamics of unfolded proteins we combined single-molecule lifetime and intensity FRET measurements with molecular simulations. We compared the unfolded states of the 64-residue, alpha / beta protein L and the 66-residue, all- beta cold-shock protein CspTm. The average radius of gyration (R sub(g)) calculated from FRET data on freely diffusing molecules was identical for the two unfolded proteins at guanidinium chloride concentrations >3 M, and the FRET-derived R sub(g) of protein L agreed well with the R sub(g) previously measured by equilibrium small-angle x-ray scattering. As the denaturant concentration was lowered, the mean FRET efficiency of the unfolded subpopulation increased, signaling collapse of the polypeptide chain, with protein L being slightly more compact than CspTm. A decrease in R sub(g) with decreasing denaturant was also observed in all-atom molecular dynamics calculations in explicit water/urea solvent, and Langevin simulations of a simplified representation of the polypeptide suggest that collapse can result from either increased interresidue attraction or decreased excluded volume. In contrast to both the FRET and simulation results, previous time-resolved small-angle x-ray scattering experiments showed no collapse for protein L. Analysis of the donor fluorescence decay of the unfolded subpopulation of both proteins gives information about the end-to-end chain distribution and suggests that chain dynamics is slow compared with the donor life-time of approximately 2 ns, whereas the bin-size independence of the small excess width above the shot noise for the FRET efficiency distributions may result from incomplete conformational averaging on even the 1-ms time scale. JF - Proceedings of the National Academy of Sciences, USA AU - Merchant, Kusai A AU - Best, Robert B AU - Louis, John M AU - Gopich, Irina V AU - Eaton, William A AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1528 EP - 1533 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 104 IS - 5 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Subpopulations KW - Solvents KW - fluorescence resonance energy transfer KW - Chloride KW - Urea KW - Spectroscopy KW - protein L KW - Protein folding KW - X-ray scattering KW - Cold shock KW - Signal transduction KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19550260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Characterizing+the+unfolded+states+of+proteins+using+single-molecule+FRET+spectroscopy+and+molecular+simulations&rft.au=Merchant%2C+Kusai+A%3BBest%2C+Robert+B%3BLouis%2C+John+M%3BGopich%2C+Irina+V%3BEaton%2C+William+A&rft.aulast=Merchant&rft.aufirst=Kusai&rft.date=2007-01-01&rft.volume=104&rft.issue=5&rft.spage=1528&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - fluorescence resonance energy transfer; protein L; Protein folding; X-ray scattering; Subpopulations; Urea; Solvents; Signal transduction; Fluorescence; Spectroscopy; Chloride; Cold shock ER - TY - JOUR T1 - GenBank AN - 19543782; 7254402 AB - GenBank (R) is a comprehensive database that contains publicly available nucleotide sequences for more than 240 000 named organisms, obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects. Most submissions are made using the web-based BankIt or standalone Sequin programs and accession numbers are assigned by GenBank staff upon receipt. Daily data exchange with the EMBL Data Library in Europe and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through NCBI's retrieval system, Entrez, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. To access GenBank and its related retrieval and analysis services, begin at the NCBI Homepage (www.ncbi.nlm.nih.gov). JF - Nucleic Acids Research AU - Benson, Dennis A AU - Karsch-Mizrachi, Ilene AU - Lipman, David J AU - Ostell, James AU - Wheeler, David L AD - National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D21 EP - D25 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Peptide mapping KW - Nucleotide sequence KW - Protein structure KW - Data banks KW - Computer programs KW - Databases KW - DNA KW - Taxonomy KW - Amino acid sequence KW - Gene mapping KW - N 14845:Miscellaneous KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19543782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=GenBank&rft.au=Benson%2C+Dennis+A%3BKarsch-Mizrachi%2C+Ilene%3BLipman%2C+David+J%3BOstell%2C+James%3BWheeler%2C+David+L&rft.aulast=Benson&rft.aufirst=Dennis&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D21&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Nucleotide sequence; DNA; Data banks; Peptide mapping; Computer programs; Genomes; Gene mapping; Taxonomy; Protein structure; Amino acid sequence ER - TY - JOUR T1 - Database resources of the National Center for Biotechnology Information AN - 19543673; 7254485 AB - In addition to maintaining the GenBank super( registered ) nucleic acid sequence database, the National Center for Biotechnology Information (NCBI) provides analysis and retrieval resources for the data in GenBank and other biological data made available through NCBI's Web site. NCBI resources include Entrez, the Entrez Programming Utilities, My NCBI, PubMed, PubMed Central, Entrez Gene, the NCBI Taxonomy Browser, BLAST, BLAST Link(BLink), Electronic PCR, OrfFinder, Spidey, Splign, RefSeq, UniGene, HomoloGene, ProtEST, dbMHC, dbSNP, Cancer Chromosomes, Entrez Genome, Genome Project and related tools, the Trace and Assembly Archives, the Map Viewer, Model Maker, Evidence Viewer, Clusters of Orthologous Groups (COGs), Viral Genotyping Tools, Influenza Viral Resources, HIV-1/Human Protein Interaction Database, Gene Expression Omnibus (GEO), Entrez Probe, GENSAT, Online Mendelian Inheritance in Man (OMIM), Online Mendelian Inheritance in Animals (OMIA), the Molecular Modeling Database (MMDB), the Conserved Domain Database (CDD), the Conserved Domain Architecture Retrieval Tool (CDART) and the PubChem suite of small molecule databases. Augmenting many of the Web applications are custom implementations of the BLAST program optimized to search specialized data sets. These resources can be accessed through the NCBI home page at www.ncbi.nlm.nih.gov. JF - Nucleic Acids Research AU - Wheeler, David L AU - Barrett, Tanya AU - Benson, Dennis A AU - Bryant, Stephen H AU - Canese, Kathi AU - Chetvernin, Vyacheslav AU - Church, Deanna M AU - DiCuccio, Michael AU - Edgar, Ron AU - Federhen, Scott AU - Geer, Lewis Y AU - Kapustin, Yuri AU - Khovayko, Oleg AU - Landsman, David AU - Lipman, David J AU - Madden, Thomas L AU - Maglott, Donna R AU - Ostell, James AU - Miller, Vadim AU - Pruitt, Kim D AU - Schuler, Gregory D AU - Sequeira, Edwin AU - Sherry, Steven T AU - Sirotkin, Karl AU - Souvorov, Alexandre AU - Starchenko, Grigory AU - Tatusov, Roman L AU - Tatusova, Tatiana A AU - Wagner, Lukas AU - Yaschenko, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D5 EP - D12 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Molecular modelling KW - Heredity KW - DNA probes KW - Gene expression KW - Influenza KW - Computer programs KW - Chromosomes KW - Polymerase chain reaction KW - Genotyping KW - Cancer KW - Databases KW - nucleic acids KW - Taxonomy KW - Protein interaction KW - N 14810:Methods KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19543673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Database+resources+of+the+National+Center+for+Biotechnology+Information&rft.au=Wheeler%2C+David+L%3BBarrett%2C+Tanya%3BBenson%2C+Dennis+A%3BBryant%2C+Stephen+H%3BCanese%2C+Kathi%3BChetvernin%2C+Vyacheslav%3BChurch%2C+Deanna+M%3BDiCuccio%2C+Michael%3BEdgar%2C+Ron%3BFederhen%2C+Scott%3BGeer%2C+Lewis+Y%3BKapustin%2C+Yuri%3BKhovayko%2C+Oleg%3BLandsman%2C+David%3BLipman%2C+David+J%3BMadden%2C+Thomas+L%3BMaglott%2C+Donna+R%3BOstell%2C+James%3BMiller%2C+Vadim%3BPruitt%2C+Kim+D%3BSchuler%2C+Gregory+D%3BSequeira%2C+Edwin%3BSherry%2C+Steven+T%3BSirotkin%2C+Karl%3BSouvorov%2C+Alexandre%3BStarchenko%2C+Grigory%3BTatusov%2C+Roman+L%3BTatusova%2C+Tatiana+A%3BWagner%2C+Lukas%3BYaschenko%2C+Eugene&rft.aulast=Wheeler&rft.aufirst=David&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D5&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Databases; Heredity; Molecular modelling; Genomes; Influenza; Computer programs; Genotyping; Protein interaction; Gene expression; Chromosomes; Cancer; nucleic acids; Taxonomy; DNA probes; Polymerase chain reaction ER - TY - JOUR T1 - Oral Vaccination with Salmonella Simultaneously Expressing Yersinia pestis F1 and V Antigens Protects against Bubonic and Pneumonic Plague AN - 19543631; 7253289 AB - The gut provides a large area for immunization enabling the development of mucosal and systemic Ab responses. To test whether the protective Ags to Yersinia pestis can be orally delivered, the Y. pestis caf1 operon, encoding the F1-Ag and virulence Ag (V-Ag) were cloned into attenuated Salmonella vaccine vectors. F1-Ag expression was controlled under a promoter from the caf1 operon; two different promoters (P), PtetA in pV3, PphoP in pV4, as well as a chimera of the two in pV55 were tested. F1-Ag was amply expressed; the chimera in the pV55 showed the best V-Ag expression. Oral immunization with Salmonella-F1 elicited elevated secretory (S)-IgA and serum IgG titers, and Salmonella-V-Ag(pV55) elicited much greater S-IgA and serum IgG Ab titers than Salmonella-V-Ag(pV3) or Salmonella-V-Ag(pV4). Hence, a new Salmonella vaccine, Salmonella-(F1+V)Ags, made with a single plasmid containing the caf1 operon and the chimeric promoter for V-Ag allowed the simultaneous expression of F1 capsule and V-Ag. Salmonella-(F1+V)Ags elicited elevated Ab titers similar to their monotypic derivatives. For bubonic plague, mice dosed with Salmonella-(F1+V)Ags and Salmonella-F1-Ag showed similar efficacy (>83% survival) against similar to 1000 LD sub(50) Y. pestis. For pneumonic plague, immunized mice required immunity to both F1- and V-Ags because the mice vaccinated with Salmonella-(F1+V)Ags protected against 100 LD sub(50) Y. pestis. These results show that a single Salmonella vaccine can deliver both F1- and V-Ags to effect both systemic and mucosal immune protection against Y. pestis. JF - Journal of Immunology AU - Yang, Xinghong AU - Hinnebusch, BJoseph AU - Trunkle, Theresa AU - Bosio, Catharine M AU - Suo, Zhiyong AU - Tighe, Mike AU - Harmsen, Ann AU - Becker, Todd AU - Crist, Kathryn AU - Walters, Nancy AU - Avci, Recep AU - Pascual, David W AD - Veterinary Molecular Biology, Montana State University, Bozeman, MT 59717. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840. Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80521. Physics Department, Montana State University, Bozeman, MT 59717 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1059 EP - 1067 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 178 IS - 2 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mucosal immunity KW - Yersinia pestis KW - Survival KW - Immunity KW - Plasmids KW - Vaccination KW - Virulence KW - Chimeras KW - Promoters KW - Digestive tract KW - Immunoglobulin G KW - Vaccines KW - Plague KW - Operons KW - Salmonella KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19543631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Oral+Vaccination+with+Salmonella+Simultaneously+Expressing+Yersinia+pestis+F1+and+V+Antigens+Protects+against+Bubonic+and+Pneumonic+Plague&rft.au=Yang%2C+Xinghong%3BHinnebusch%2C+BJoseph%3BTrunkle%2C+Theresa%3BBosio%2C+Catharine+M%3BSuo%2C+Zhiyong%3BTighe%2C+Mike%3BHarmsen%2C+Ann%3BBecker%2C+Todd%3BCrist%2C+Kathryn%3BWalters%2C+Nancy%3BAvci%2C+Recep%3BPascual%2C+David+W&rft.aulast=Yang&rft.aufirst=Xinghong&rft.date=2007-01-01&rft.volume=178&rft.issue=2&rft.spage=1059&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mucosal immunity; Survival; Immunity; Plasmids; Vaccination; Virulence; Promoters; Chimeras; Digestive tract; Immunoglobulin G; Plague; Vaccines; Operons; Yersinia pestis; Salmonella ER - TY - JOUR T1 - Association of Physical Activity with Development of Uterine Leiomyoma AN - 19537969; 7250303 AB - The relation between physical activity and uterine leiomyomata (fibroids) has received little study, but exercise is protective for breast cancer, another hormonally mediated tumor. Participants in this study were randomly selected members of a health plan based in Washington, DC, aged 35-49 years (734 African Americans, 455 Whites) enrolled between 1996 and 1999. Fibroid status was based on ultrasound screening. Physical activity was based on detailed interview questions. Logistic regression with adjustment for body mass index and other risk factors showed that women in the highest category of physical activity were significantly less likely to have fibroids (odds ratio = 0.6, 95% confidence interval = 0.4, 0.9 for the highest vs. the lowest category (equivalent to approximately greater than or equal to 7 hours/week vs. <2 hours/week)). There was a dose-response pattern; a significant trend was seen for both African-American and White women. A multistate Bayesian analysis indicated that exercise was associated with tumor onset more strongly than with tumor growth. When data for women who reported major fibroid-related symptoms were excluded, results remained essentially unchanged, suggesting that the observed association could not be attributed to reverse causation (fibroids preventing exercise). The authors concluded that regular exercise might help women prevent fibroids. JF - American Journal of Epidemiology AU - Baird, Donna Day AU - Dunson, David B AU - Hill, Michael C AU - Cousins, Deborah AU - Schectman, Joel M AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 157 EP - 163 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 2 SN - 0002-9262, 0002-9262 KW - Physical Education Index KW - Blacks KW - Preventive health KW - Body mass KW - Women KW - Breasts KW - Tumors KW - Exercise KW - Cancer KW - Epidemiology KW - Risk factors KW - Analysis KW - Interviews KW - Trends KW - Ultrasound KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19537969?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Association+of+Physical+Activity+with+Development+of+Uterine+Leiomyoma&rft.au=Baird%2C+Donna+Day%3BDunson%2C+David+B%3BHill%2C+Michael+C%3BCousins%2C+Deborah%3BSchectman%2C+Joel+M&rft.aulast=Baird&rft.aufirst=Donna&rft.date=2007-01-01&rft.volume=165&rft.issue=2&rft.spage=157&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Preventive health; Blacks; Body mass; Women; Breasts; Exercise; Tumors; Cancer; Epidemiology; Analysis; Risk factors; Interviews; Trends; Ultrasound ER - TY - JOUR T1 - Lung injury after ozone exposure is iron dependent AN - 19532826; 7250243 AB - We tested the hypothesis that oxidative stress and biological effect after ozone (O sub(3)) exposure are dependent on changes in iron homeostasis. After O sub(3) exposure, healthy volunteers demonstrated increased lavage concentrations of iron, transferrin, lactoferrin, and ferritin. In normal rats, alterations of iron metabolism after O sub(3) exposure were immediate and preceded the inflammatory influx. To test for participation of this disruption in iron homeostasis in lung injury following O sub(3) inhalation, we exposed Belgrade rats, which are functionally deficient in divalent metal transporter 1 (DMT1) as a means of iron uptake, and controls to O sub(3). Iron homeostasis was disrupted to a greater extent and the extent of injury was greater in Belgrade rats than in control rats. Nonheme iron and ferritin concentrations were higher in human bronchial epithelial (HBE) cells exposed to O sub(3) than in HBE cells exposed to filtered air. Aldehyde generation and IL-8 release by the HBE cells was also elevated following O sub(3) exposure. Human embryonic kidney (HEK 293) cells with elevated expression of a DMT1 construct were exposed to filtered air and O sub(3). With exposure to O sub(3), elevated DMT1 expression diminished oxidative stress (i.e., aldehyde generation) and IL-8 release. We conclude that iron participates critically in the oxidative stress and biological effects after O sub(3) exposure. JF - American Journal of Physiology: Lung Cellular and Molecular Physiology AU - Ghio, Andrew J AU - Turi, Jennifer L AU - Madden, Michael C AU - Dailey, Lisa A AU - Richards, Judy D AU - Stonehuerner, Jacqueline G AU - Morgan, Daniel L AU - Singleton, Steven AU - Garrick, Laura M AU - Garrick, Michael D AD - National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, and National Institute of Environmental Health Sciences and National Toxicology Program, Research Triangle Park Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - L134 EP - L143 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 292 IS - 1 SN - 1040-0605, 1040-0605 KW - Toxicology Abstracts KW - Inhalation KW - Injuries KW - Homeostasis KW - Interleukin 8 KW - Inflammation KW - Divalent metal transporter-1 KW - Transferrin KW - Lung KW - Oxidative stress KW - lactoferrin KW - Embryos KW - Ferritin KW - Aldehydes KW - Iron KW - Metabolism KW - Ozone KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19532826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.atitle=Lung+injury+after+ozone+exposure+is+iron+dependent&rft.au=Ghio%2C+Andrew+J%3BTuri%2C+Jennifer+L%3BMadden%2C+Michael+C%3BDailey%2C+Lisa+A%3BRichards%2C+Judy+D%3BStonehuerner%2C+Jacqueline+G%3BMorgan%2C+Daniel+L%3BSingleton%2C+Steven%3BGarrick%2C+Laura+M%3BGarrick%2C+Michael+D&rft.aulast=Ghio&rft.aufirst=Andrew&rft.date=2007-01-01&rft.volume=292&rft.issue=1&rft.spage=L134&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Lung+Cellular+and+Molecular+Physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Injuries; Homeostasis; Interleukin 8; Inflammation; Transferrin; Divalent metal transporter-1; Oxidative stress; Lung; lactoferrin; Ferritin; Embryos; Aldehydes; Iron; Metabolism; Ozone ER - TY - JOUR T1 - Methodological issues regarding confounding and exposure misclassification in epidemiological studies of occupational exposures AN - 19521186; 7349975 AB - Background: Confounding and exposure misclassification are issues that concern epidemiologists because of their potential to bias results of studies and complicate interpretations. In occupational epidemiology both are routinely raised to argue that an observed result is either a false positive or a false negative finding. Although it is important to consider the potential for limitations of epidemiologic investigations, judgment regarding their importance should be based on their actual likelihood of occurrence. Methods: This paper is based on our experience in epidemiologic analyses and a brief review of the literature regarding confounding and exposure misclassification. Results: Examples of substantial confounding are rare in occupational epidemiology. In fact, even for studies of occupational exposures and lung cancer, tobacco- adjusted relative risks rarely differ appreciably from the unadjusted estimates. This is surprising because it seems the perfect situation for confounding to occur. Yet, despite the lack of evidence that confounding is a common problem, nearly every epidemiologic paper includes a lengthy discussion on uncontrolled or residual confounding. On the other hand, exposure misclassification probably occurs in all studies. The only question is, how much? The direction and magnitude of nondifferential exposure misclassification (the type most likely to occur in cohort studies) on estimates of relative risks can be largely predicted given knowledge on the degree of misclassification, that is, relatively small amounts of misclassification can bias relative risks substantially towards the null. The literature, however, is full of discussions implying that misclassification of exposure is an explanation for a positive finding. Conclusions: These comments are not to suggest that all potential limitations for epidemiologic studies should not be considered and evaluated. We do believe, however, that the likelihood of occurrence and the direction and magnitude of the effect should be more carefully and realistically considered when making judgments about study design or data interpretation. Am. J. Ind. Med. 50: 199- 207, 2007. JF - American Journal of Industrial Medicine AU - Blair, Aaron AU - Stewart, Patricia AU - Lubin, Jay H AU - Forastiere, Francesco AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland Y1 - 2007 PY - 2007 DA - 2007 SP - 199 EP - 207 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 50 IS - 3 SN - 0271-3586, 0271-3586 KW - Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - confounding KW - exposure misclassification KW - methods KW - occupational epidemiology KW - Risk assessment KW - Epidemiology KW - Reviews KW - Occupational exposure KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 1000:Occupational Safety and Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521186?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Industrial+Medicine&rft.atitle=Methodological+issues+regarding+confounding+and+exposure+misclassification+in+epidemiological+studies+of+occupational+exposures&rft.au=Blair%2C+Aaron%3BStewart%2C+Patricia%3BLubin%2C+Jay+H%3BForastiere%2C+Francesco&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2007-01-01&rft.volume=50&rft.issue=3&rft.spage=199&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Industrial+Medicine&rft.issn=02713586&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Epidemiology; Reviews; Occupational exposure; Lung cancer ER - TY - JOUR T1 - Can Biomarkers Help Us Understand the Nutritional and Lifestyle Factors Important in Cancer Prognosis? AN - 19519405; 7210034 AB - In attempting to discover the causes of cancer, investigators have recognized that biomarkers can confirm biological plausibility, enhance relative risks, and serve as surrogate endpoints in observational and intervention studies. In the arena of cancer survival, the potential value of biomarkers is increasingly appreciated. A broad range of histological, cellular, and molecular markers have been identified among persons diagnosed with cancer. Molecular and cellular markers are being used to stage disease, predict prognosis, and target therapeutic interventions. Biomarkers in survivors can also help us to understand factors that influence prognosis by both elucidating pertinent biological pathways and sharpening risk estimates. However, as in the case of incident cancer, the use of biomarkers as surrogate endpoints postdiagnosis is problematic because of the potential existence of alternative pathways to recurrence and death that bypass the surrogate endpoint. In evaluating potential surrogates, an understanding of the causal structure underlying the interrelations of exposures, surrogate, and recurrence or death is essential. Three questions can help to shed light on this structure: 1) What is the relation of the surrogate endpoint to recurrence or death? 2) What is the relation of the intervention (or exposure) to the surrogate? 3) To what extent does the surrogate endpoint mediate the relation between intervention (exposure) and recurrence or death? To address these questions, it is imperative to integrate biomarker studies into ongoing pharmacotherapeutic and lifestyle intervention studies with recurrence or mortality as explicit endpoints. JF - Journal of Nutrition AU - Schatzkin, Arthur AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20815 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 249S EP - 252S PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 137 IS - 1 SN - 0022-3166, 0022-3166 KW - Risk Abstracts KW - Bioindicators KW - Mortality KW - intervention KW - survival KW - Nutrition KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19519405?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=Can+Biomarkers+Help+Us+Understand+the+Nutritional+and+Lifestyle+Factors+Important+in+Cancer+Prognosis%3F&rft.au=Schatzkin%2C+Arthur&rft.aulast=Schatzkin&rft.aufirst=Arthur&rft.date=2007-01-01&rft.volume=137&rft.issue=1&rft.spage=249S&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Bioindicators; Mortality; intervention; survival; Nutrition; Cancer ER - TY - JOUR T1 - Binge Eating in Overweight Treatment-Seeking Adolescents AN - 19518936; 7209364 AB - OBJECTIVE: To examine the frequency and recency of binge eating in relation to psychopathology in overweight, treatment-seeking adolescents. METHODS: We investigated psychological correlates of the frequency and recency of reported loss of control (LOC) eating episodes in 160 overweight (body mass index [BMI]: 40.7 plus or minus 8.8 kg/m super(2)) adolescents. On the basis of the responses to the eating disorder examination (EDE), participants were categorized into one of four groups: full-syndrome binge eating disorder (BED); recent but infrequent binge eating (episodes within the 3 months before interview; RECENT-BINGE); remote and infrequent LOC eating (episodes occurring >3 months before assessment; PAST-LOC), or no history of LOC episodes (NE). RESULTS: The BED group reported higher EDE scores (global, p < .01), and more negative mood and anxiety than all other groups (p's < .01). Compared with NE, RECENT-BINGE also reported more anxiety and higher EDE scores (p's < .01). CONCLUSIONS: Overweight, treatment-seeking adolescents with BED are clearly distinguishable from teens without the disorder on measures of eating-related psychopathology, mood, and anxiety. RECENT-BINGE, but not PAST-LOC, is also associated with significantly greater eating-related and general psychopathology. JF - Journal of Pediatric Psychology AU - Glasofer, Deborah R AU - Tanofsky-Kraff, Marian AU - Eddy, Kamryn T AU - Yanovski, Susan Z AU - Theim, Kelly R AU - Mirch, Margaret C AU - Ghorbani, Samareh AU - Ranzenhofer, Lisa M AU - Haaga, David AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development. Department of Psychology, American University. Center for Anxiety and Related Disorders, Boston University. Optimal Weight for Life Clinic, Children's Hospital. Division of Digestive Diseases and Nutrition, and. Division of Nutrition Research Coordination, National Institute of Diabetes and Digestive Kidney Diseases, National Institutes of Health, DHHS Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 95 EP - 105 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 32 IS - 1 SN - 0146-8693, 0146-8693 KW - Physical Education Index KW - Obesity KW - Anxiety KW - Eating disorders KW - Psychology KW - Pediatrics KW - Adolescence KW - Body mass KW - Evaluation KW - Moods KW - Diet KW - Interviews KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19518936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Pediatric+Psychology&rft.atitle=Binge+Eating+in+Overweight+Treatment-Seeking+Adolescents&rft.au=Glasofer%2C+Deborah+R%3BTanofsky-Kraff%2C+Marian%3BEddy%2C+Kamryn+T%3BYanovski%2C+Susan+Z%3BTheim%2C+Kelly+R%3BMirch%2C+Margaret+C%3BGhorbani%2C+Samareh%3BRanzenhofer%2C+Lisa+M%3BHaaga%2C+David%3BYanovski%2C+Jack+A&rft.aulast=Glasofer&rft.aufirst=Deborah&rft.date=2007-01-01&rft.volume=32&rft.issue=1&rft.spage=95&rft.isbn=&rft.btitle=&rft.title=Journal+of+Pediatric+Psychology&rft.issn=01468693&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Obesity; Anxiety; Pediatrics; Psychology; Eating disorders; Body mass; Adolescence; Moods; Interviews; Diet; Youth ER - TY - JOUR T1 - Analysis and prediction of functionally important sites in proteins AN - 19517972; 7210595 AB - The rapidly increasing volume of sequence and structure information available for proteins poses the daunting task of determining their functional importance. Computational methods can prove to be very useful in understanding and characterizing the biochemical and evolutionary information contained in this wealth of data, particularly at functionally important sites. Therefore, we perform a detailed survey of compositional and evolutionary constraints at the molecular and biological function level for a large set of known functionally important sites extracted from a wide range of protein families. We compare the degree of conservation across different functional categories and provide detailed statistical insight to decipher the varying evolutionary constraints at functionally important sites. The compositional and evolutionary information at functionally important sites has been compiled into a library of functional templates. We developed a module that predicts functionally important columns (FIC) of an alignment based on the detection of a significant "template match score" to a library template. Our template match score measures an alignment column's similarity to a library template and combines a term explicitly representing a column's residue composition with various evolutionary conservation scores (information content and position-specific scoring matrix-derived statistics). Our benchmarking studies show good sensitivity/specificity for the prediction of functional sites and high accuracy in attributing correct molecular function type to the predicted sites. This prediction method is based on information derived from homologous sequences and no structural information is required. Therefore, this method could be extremely useful for large-scale functional annotation. JF - Protein Science AU - Chakrabarti, Saikat AU - Lanczycki, Christopher J AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 4 EP - 13 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 1 SN - 0961-8368, 0961-8368 KW - Biotechnology and Bioengineering Abstracts KW - Evolutionary conservation KW - Statistical analysis KW - protein families KW - Computer applications KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19517972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Analysis+and+prediction+of+functionally+important+sites+in+proteins&rft.au=Chakrabarti%2C+Saikat%3BLanczycki%2C+Christopher+J&rft.aulast=Chakrabarti&rft.aufirst=Saikat&rft.date=2007-01-01&rft.volume=16&rft.issue=1&rft.spage=4&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Evolutionary conservation; Statistical analysis; protein families; Computer applications ER - TY - JOUR T1 - CYP2E1 AN - 19517315; 7207219 AB - Bernard B. Brodie's laboratory was the first to examine the mechanisms of drug-induced toxicity at the molecular level. They found that acetaminophen hepatotoxicity was due to the metabolic activation of the drug to a highly reactive toxic metabolite that depleted cellular glutathione and covalently bound to protein. Subsequent studies revealed that activation of acetaminophen to an active metabolite is primarily carried out by CYP2E1, an ethanol-inducible cytochrome P450 that was first suggested by characterization of the microsomal ethanol oxidation system. CYP2E1 is developmentally regulated, under liver-specific control, and undergoes substrate-induced protein stabilization. It is also regulated by starvation and diabetes through insulin-dependent mRNA stabilization. In addition to acetaminophen, CYP2E1 metabolically activates a large number of low M sub(r) toxicants and carcinogens and thus is of great toxicological importance. The mechanism of regulation CYP2E1 and its role in acetaminophen toxicity will be discussed. JF - Drug Metabolism and Disposition AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 1 EP - 8 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 35 IS - 1 SN - 0090-9556, 0090-9556 KW - Toxicology Abstracts KW - Starvation KW - Toxicants KW - Glutathione KW - Metabolites KW - Carcinogens KW - Toxicity KW - Drug abuse KW - hepatotoxicity KW - mRNA KW - Diabetes mellitus KW - Oxidation KW - Metabolic activation KW - Cytochrome P450 KW - Acetaminophen KW - Ethanol KW - X 24310:Pharmaceuticals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19517315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=CYP2E1&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2007-01-01&rft.volume=35&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Starvation; Toxicants; Glutathione; Metabolites; Toxicity; Carcinogens; Drug abuse; hepatotoxicity; mRNA; Diabetes mellitus; Oxidation; Metabolic activation; Cytochrome P450; Acetaminophen; Ethanol ER - TY - JOUR T1 - Cerebrospinal Fluid-Infiltrating CD4 super(+) T Cells Recognize Borrelia burgdorferi Lysine-Enriched Protein Domains and Central Nervous System Autoantigens in Early Lyme Encephalitis AN - 19516097; 7207598 AB - Neurological manifestations of Lyme disease are usually accompanied by inflammatory changes in the cerebrospinal fluid (CSF) and the recruitment of activated T cells into the CSF compartment. In order to characterize the phenotype and identify target antigens of CSF-infiltrating T cells in early neuroborreliosis with central nervous system (CNS) involvement, we combined T-cell cloning, functional testing of T-cell responses with positional scanning synthetic combinatorial peptide libraries, and biometric data analysis. We demonstrate that CD4 super(+) gamma interferon-producing T cells specifically responding to Borrelia burgdorferi lysate were present in the CSF of a patient with acute Lyme encephalitis. Some T-cell clones recognized previously uncharacterized B. burgdorferi epitopes which show a specific enrichment for lysine, such as the heat shock-induced chaperone HSP90. Degenerate T-cell recognition that included T-cell responses to borrelia-specific and CNS-specific autoantigens derived from the myelin protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) could be demonstrated for one representative clone. Our results show that spirochetal antigen-specific and Th1-polarized CD4 super(+) lymphocytes infiltrate the CSF during monophasic CNS symptoms of Lyme disease and demonstrate that cross-recognition of CNS antigens by B. burgdorferi-specific T cells is not restricted to chronic and treatment-resistant manifestations. JF - Infection and Immunity AU - Luenemann, Jan D AU - Gelderblom, Harald AU - Sospedra, Mireia AU - Quandt, Jacqueline A AU - Pinilla, Clemencia AU - Marques, Adriana AU - Martin, Roland AD - Neuroimmunology Branch, Cellular Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892. Institute for Neuroimmunology and Clinical MS Research (INiMS), Center for Molecular Neurobiology Hamburg (ZMNH), University Clinic Eppendorf, Falkenried 94, 20251 Hamburg, Germany. Mixture Science and Torrey Pines Institute for Molecular Studies, San Diego, California 92121. Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892. Laboratory of Viral Immunobiology, The Rockefeller University, New York, New York 10021. Department of Neurology and Psychiatry, Charite Medical Center, Humboldt University, 10098 Berlin, Germany Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 243 EP - 251 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 1 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Central nervous system KW - Data processing KW - Myelin KW - Borrelia burgdorferi KW - Lymphocytes B KW - Lysine KW - Biometrics KW - Peptide libraries KW - Encephalitis KW - Autoantigens KW - Nucleotides KW - Inflammation KW - Hsp90 protein KW - CD4 antigen KW - Cerebrospinal fluid KW - Scanning KW - Heat KW - Borreliosis KW - Lymphocytes T KW - Chaperones KW - Epitopes KW - Lyme disease KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites KW - N3 11024:Neuroimmunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19516097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Cerebrospinal+Fluid-Infiltrating+CD4+super%28%2B%29+T+Cells+Recognize+Borrelia+burgdorferi+Lysine-Enriched+Protein+Domains+and+Central+Nervous+System+Autoantigens+in+Early+Lyme+Encephalitis&rft.au=Luenemann%2C+Jan+D%3BGelderblom%2C+Harald%3BSospedra%2C+Mireia%3BQuandt%2C+Jacqueline+A%3BPinilla%2C+Clemencia%3BMarques%2C+Adriana%3BMartin%2C+Roland&rft.aulast=Luenemann&rft.aufirst=Jan&rft.date=2007-01-01&rft.volume=75&rft.issue=1&rft.spage=243&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Central nervous system; Data processing; Myelin; Lymphocytes B; Lysine; Biometrics; Peptide libraries; Nucleotides; Autoantigens; Encephalitis; Inflammation; Hsp90 protein; Cerebrospinal fluid; CD4 antigen; Scanning; Heat; Borreliosis; Lymphocytes T; Chaperones; Epitopes; Lyme disease; Borrelia burgdorferi ER - TY - JOUR T1 - Inhalational Exposure to Carbonyl Sulfide Produces Altered Brainstem Auditory and Somatosensory-Evoked Potentials in Fischer 344N Rats AN - 19515662; 7210974 AB - Carbonyl sulfide (COS), a chemical listed by the original Clean Air Act, was tested for neurotoxicity by a National Institute of Environmental Health Sciences/National Toxicology Program and U.S. Environmental Protection Agency collaborative investigation. Previous studies demonstrated that COS produced cortical and brainstem lesions and altered auditory neurophysiological responses to click stimuli. This paper reports the results of expanded neurophysiological examinations that were an integral part of the previously published experiments (Morgan et al., 2004, TOXICOL: Appl. Pharmacol. 200, 131-145; Sills et al., 2004, TOXICOL: Pathol. 32, 1-10). Fisher 334N rats were exposed to 0, 200, 300, or 400 ppm COS for 6 h/day, 5 days/week for 12 weeks, or to 0, 300, or 400 ppm COS for 2 weeks using whole-body inhalation chambers. After treatment, the animals were studied using neurophysiological tests to examine: peripheral nerve function, somatosensory-evoked potentials (SEPs) (tail/hindlimb and facial cortical regions), brainstem auditory-evoked responses (BAERs), and visual flash-evoked potentials (2-week study). Additionally, the animals exposed for 2 weeks were examined using a functional observational battery (FOB) and response modification audiometry (RMA). Peripheral nerve function was not altered for any exposure scenario. Likewise, amplitudes of SEPs recorded from the cerebellum were not altered by treatment with COS. In contrast, amplitudes and latencies of SEPs recorded from cortical areas were altered after 12-week exposure to 400 ppm COS. The SEP waveforms were changed to a greater extent after forelimb stimulation than tail stimulation in the 2-week study. The most consistent findings were decreased amplitudes of BAER peaks associated with brainstem regions after exposure to 400 ppm COS. Additional BAER peaks were affected after 12 weeks, compared to 2 weeks of treatment, indicating that additional regions of the brainstem were damaged with longer exposures. The changes in BAERs were observed in the absence of altered auditory responsiveness in FOB or RMA. This series of experiments demonstrates that COS produces changes in brainstem auditory and cortical somatosensory neurophysiological responses that correlate with previously described histopathological damage. JF - Toxicological Sciences AU - Herr, David W AU - Graff, Jaimie E AU - Moser, Virginia C AU - Crofton, Kevin M AU - Little, Peter B AU - Morgan, Daniel L AU - Sills, Robert C AD - Neurotoxicology Division, MD B105-05, NHEERL, ORD, USEPA, Research Triangle Park, North Carolina 27711. Pathology Associates Division of Charles River Laboratories, Durham, North Carolina 27713. Respiratory Toxicology, NIEHS, Research Triangle Park, North Carolina 27709. Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina 27709 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 118 EP - 135 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 95 IS - 1 SN - 1096-6080, 1096-6080 KW - Health & Safety Science Abstracts; CSA Neurosciences Abstracts; Toxicology Abstracts KW - Inhalation KW - Cerebellum KW - Environmental health KW - Histopathology KW - Rats KW - Clean Air Act KW - Somatosensory evoked potentials KW - Cortex KW - Batteries KW - Lesions KW - carbonyl compounds KW - Toxicology KW - Tails KW - Sulfides KW - Brain stem KW - EPA KW - Sulfide KW - USA KW - Neurotoxicity KW - carbonyls KW - Peripheral nerves KW - N3 11028:Neuropharmacology & toxicology KW - H 12000:Epidemiology and Public Health KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Inhalational+Exposure+to+Carbonyl+Sulfide+Produces+Altered+Brainstem+Auditory+and+Somatosensory-Evoked+Potentials+in+Fischer+344N+Rats&rft.au=Herr%2C+David+W%3BGraff%2C+Jaimie+E%3BMoser%2C+Virginia+C%3BCrofton%2C+Kevin+M%3BLittle%2C+Peter+B%3BMorgan%2C+Daniel+L%3BSills%2C+Robert+C&rft.aulast=Herr&rft.aufirst=David&rft.date=2007-01-01&rft.volume=95&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inhalation; Somatosensory evoked potentials; Sulfide; Cortex; Batteries; Tails; Neurotoxicity; Brain stem; Cerebellum; carbonyls; Peripheral nerves; Clean Air Act; Rats; EPA; Sulfides; Lesions; Histopathology; Environmental health; carbonyl compounds; Toxicology; USA ER - TY - JOUR T1 - Proteome and Antigen Profiling of Coxiella burnetii Developmental Forms AN - 19514184; 7207603 AB - A biphasic developmental cycle whereby highly resistant small-cell variants (SCVs) are generated from large-cell variants (LCVs) is considered fundamental to the virulence of Coxiella burnetii, the causative agent of human Q fever. In this study a proteome analysis of C. burnetii developmental forms was conducted to provide insight into their unique biological and immunological properties. Silver-stained gels of SCV and LCV lysates separated by two-dimensional (2-D) gel electrophoresis resolved over 675 proteins in both developmental forms. Forty-eight proteins were greater than twofold more abundant in LCVs than in SCVs, with six proteins greater than twofold more abundant in SCVs than in LCVs. Four and 15 upregulated proteins of SCVs and LCVs, respectively, were identified by mass spectrometry, and their predicted functional roles are consistent with a metabolically active LCV and a structurally resistant SCV. One-dimensional and 2-D immunoblots of cell form lysates probed with sera from infected/vaccinated guinea pigs and convalescent-phase serum from human patients who had recovered from acute Q fever, respectively, revealed both unique SCV/LCV antigens and common SCV/LCV antigens that were often differentially synthesized. Antigens recognized during human infection were identified by mass spectroscopy and included both previously described immunodominant proteins of C. burnetii and novel immunogenic proteins that may be important in the pathophysiology of clinical Q fever and/or the induction of protective immunity. JF - Infection and Immunity AU - Coleman, Sherry A AU - Fischer, Elizabeth R AU - Cockrell, Diane C AU - Voth, Daniel E AU - Howe, Dale AU - Mead, David J AU - Samuel, James E AU - Heinzen, Robert A AD - Coxiella Pathogenesis Section. Host-Parasite Interactions Section, Laboratory of Intracellular Parasites. Microscopy Unit, Research Technology Section, Research Technology Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Medical Microbiology and Immunology, Texas A&M University System Health Science Center, College Station, Texas 77843-1114 Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 290 EP - 298 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 75 IS - 1 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Virulence KW - Coxiella burnetii KW - Immunity KW - Infection KW - Q fever KW - double prime Q fever KW - Gel electrophoresis KW - Mass spectroscopy KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19514184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Proteome+and+Antigen+Profiling+of+Coxiella+burnetii+Developmental+Forms&rft.au=Coleman%2C+Sherry+A%3BFischer%2C+Elizabeth+R%3BCockrell%2C+Diane+C%3BVoth%2C+Daniel+E%3BHowe%2C+Dale%3BMead%2C+David+J%3BSamuel%2C+James+E%3BHeinzen%2C+Robert+A&rft.aulast=Coleman&rft.aufirst=Sherry&rft.date=2007-01-01&rft.volume=75&rft.issue=1&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virulence; Immunity; Infection; Q fever; Mass spectroscopy; Gel electrophoresis; double prime Q fever; Coxiella burnetii ER - TY - JOUR T1 - Personal Hair Dye Use and Risks of Glioma, Meningioma, and Acoustic Neuroma among Adults AN - 19508288; 7205578 AB - Previous studies have suggested an association of personal hair dye use with bladder and hematopoietic cancers. Risks for brain tumors are not well understood. The authors investigated associations between use of synthetic hair dyes and risk of brain tumors in a hospital-based case-control study. The study included adults newly diagnosed with glioma (n = 489), meningioma (n = 197), or acoustic neuroma (n = 96) between 1994 and 1998 at three urban US hospitals and 799 controls. Odds ratios were estimated and 95% confidence intervals were calculated using unconditional logistic regression. Detailed exposure histories were obtained by interview. There was no consistent pattern of elevated odds ratios for glioma, meningioma, or acoustic neuroma with use or prolonged use of permanent, semipermanent, temporary, or gradual hair dyes. Although use of permanent brown hair dye for 20 or more years was associated with glioma among women, the estimate was imprecise (odds ratio = 3.8, 95% confidence interval: 1.2, 12.5) and was based on just 13 exposed cases; thus, this could be a chance finding. Overall, there was little consistent evidence for an association of synthetic hair dye use with glioma, meningioma, or acoustic neuroma. However, prolonged use of dark-colored permanent dyes warrants further investigation given the high prevalence of hair dyeing. JF - American Journal of Epidemiology AU - Bluhm, Elizabeth C AU - Zahm, Shelia Hoar AU - Fine, Howard A AU - Black, Peter M AU - Loeffler, Jay S AU - Shapiro, William R AU - Selker, Robert G AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD Y1 - 2007/01/01/ PY - 2007 DA - 2007 Jan 01 SP - 63 EP - 71 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 165 IS - 1 SN - 0002-9262, 0002-9262 KW - CSA Neurosciences Abstracts; Health & Safety Science Abstracts; Risk Abstracts; Toxicology Abstracts KW - Historical account KW - Consumer products KW - Urinary bladder KW - Hair KW - Cancer KW - Neoplasia KW - Brain tumors KW - Dyes KW - Hemopoiesis KW - Hair dyes KW - Glioma KW - brain tumors KW - meningioma KW - Hospitals KW - X 24340:Cosmetics, Toiletries & Household Products KW - H 11000:Diseases/Injuries/Trauma KW - N3 11028:Neuropharmacology & toxicology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19508288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=Personal+Hair+Dye+Use+and+Risks+of+Glioma%2C+Meningioma%2C+and+Acoustic+Neuroma+among+Adults&rft.au=Bluhm%2C+Elizabeth+C%3BZahm%2C+Shelia+Hoar%3BFine%2C+Howard+A%3BBlack%2C+Peter+M%3BLoeffler%2C+Jay+S%3BShapiro%2C+William+R%3BSelker%2C+Robert+G%3BInskip%2C+Peter+D&rft.aulast=Bluhm&rft.aufirst=Elizabeth&rft.date=2007-01-01&rft.volume=165&rft.issue=1&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain tumors; Dyes; Urinary bladder; Hemopoiesis; Hair dyes; Glioma; Hair; Neoplasia; meningioma; Hospitals; Historical account; Consumer products; brain tumors; Cancer ER - TY - JOUR T1 - In vitro induction and selection of fluoroquinolone-resistant mutants of Streptococcus pyogenes strains with multiple emm types AN - 19506859; 7207694 AB - OBJECTIVES: To perform a systematic analysis of point mutations in the quinolone resistance determining regions (QRDRs) of the DNA gyrase and topoisomerase genes of emm type 6 and other emm types of Streptococcus pyogenes strains after in vitro exposure to stepwise increasing concentrations of levofloxacin. METHODS: Twelve parent strains of S. pyogenes, each with a different emm type, were chosen for stepwise exposure to increasing levels of levofloxacin followed by selection of resistant mutants. The QRDRs of gyrA, gyrB, parC and parE correlating to mutants with increased MICs were analysed for point mutations. RESULTS: Multiple mutants with significantly increased MICs were generated from each strain. The amino acid substitutions identified were consistent regardless of emm type and were similar to the mechanisms of resistance reported in clinical isolates of S. pyogenes. The number of induction/selection cycles required for the emergence of key point mutations in gyrA and parC was variable among strains. For each parent-mutant set, when MIC increased, serine-81 of gyrA and serine-79 of parC were the primary targets for amino acid substitutions. No point mutations were found in the QRDRs of gyrB and parE in any of the resistant mutants sequenced. CONCLUSIONS: Despite its intrinsic polymorphism in the QRDR of parC, emm type 6 is not more likely to develop high-level resistance to fluoroquinolones when compared with other emm types. All emm types seem equally inducible to high-level fluoroquinolone resistance. JF - Journal of Antimicrobial Chemotherapy AU - Billal, Dewan S AU - Fedorko, Daniel P AU - Yan, SSteve AU - Hotomi, Muneki AU - Fujihara, Keiji AU - Nelson, Nancy AU - Yamanaka, Noboru AD - Department of Otolaryngology-Head and Neck Surgery, Wakayama Medical University 811-1 Kimiidera, Wakayama, 641-8510, Japan. Clinical Center, National Institutes of Health, Department of Health and Human Services Bethesda, MD 20892, USA. Food and Drug Administration, Department of Health and Human Services Rockville, MD 20855, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 28 EP - 34 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 59 IS - 1 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Amino acid substitution KW - Fluoroquinolones KW - Levofloxacin KW - Point mutation KW - Quinolones KW - DNA topoisomerase KW - Resistant mutant KW - Minimum inhibitory concentration KW - Streptococcus pyogenes KW - DNA topoisomerase IV KW - A 01350:Microbial Resistance KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=In+vitro+induction+and+selection+of+fluoroquinolone-resistant+mutants+of+Streptococcus+pyogenes+strains+with+multiple+emm+types&rft.au=Billal%2C+Dewan+S%3BFedorko%2C+Daniel+P%3BYan%2C+SSteve%3BHotomi%2C+Muneki%3BFujihara%2C+Keiji%3BNelson%2C+Nancy%3BYamanaka%2C+Noboru&rft.aulast=Billal&rft.aufirst=Dewan&rft.date=2007-01-01&rft.volume=59&rft.issue=1&rft.spage=28&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Amino acid substitution; Fluoroquinolones; Levofloxacin; Quinolones; Point mutation; DNA topoisomerase; Resistant mutant; Minimum inhibitory concentration; DNA topoisomerase IV; Streptococcus pyogenes ER - TY - JOUR T1 - Polymorphisms in Th1-type cell-mediated response genes and risk of gastric cancer AN - 19504316; 7206692 AB - Helicobacter pylori infection, the dominant risk factor for gastric cancers, has been shown to elicit T helper type 1 (Th1) polarized immunological responses. We conducted a population-based study of 305 gastric cancer cases and 427 age- and gender-matched controls in Warsaw, Poland, to evaluate the association with several variants in genes responsible for Th1-cell-mediated response. Genotyping was performed on genomic DNA by TaqMan super(TM) assays to determine TNFA (-308 G>A, -417 G>A, -555 G>A, -1036 C>T, -1042 C>A, -1210 T>C), IL1A (-889 C>T), IFNGR2 (Ex7-128 T>C, Ex2-34 C>G and Ex2-16 A>G) and IL12A (IVS2-798 T>A, IVS2-701 C>A and Ex7+277 G>A) polymorphisms. We used unconditional logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for sex, age, education and smoking status. Out of six single nucleotide polymorphisms (SNPs) tested in TNFA, gastric cancer risk was significantly associated with the TNFA (-308 G>A) polymorphism, with ORs of 1.4 (95% CI: 1.0-2.0) for the G/A and 2.5 (95% CI: 1.3-4.9) for the A/A genotype carriers, when compared with the more frequent genotype (G/G) (P-trend T polymorphism was associated with increased risk, with ORs of 1.5 (95% CI: 1.0-2.3) for T/C and 1.7 (95% CI: 1.1-2.7) for C/C carriers when compared with T/T carriers (P-trend = 0.01). Subjects carrying both IFNGR2 Ex7-128 C/C and TNFA -308 A/A genotypes had the highest risk (OR = 5.5, 95% CI: 1.5-19.4), although the interaction was not statistically significant. IL1A (-889 C>T) and the three examined IL12A variants were unrelated to gastric cancer risk. Our findings suggest that two Th1-related polymorphisms (TNFA -308 A>G and IFNGR2 Ex7-128 C>T) may increase the risk of gastric cancer. JF - Carcinogenesis AU - Hou, L AU - El-Omar, E M AU - Chen, J AU - Grillo, P AU - Rabkin, C S AU - Baccarelli, A AU - Yeager, M AU - Chanock, S J AU - Zatonski, W AU - Sobin, L H AU - Lissowska, J AU - Fraumeni, JFJr AU - Chow, W H AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute 6120 Executive Boulevard, EPS 8123, Bethesda, MD 20852-7242, USA. Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen Foresterhill, Aberdeen, AB25 2ZD, UK. Molecular and Genetic Epidemiology Center-Epidemiology Unit, Department of Occupational, Clinical and Preventive Medicine, IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, I-20122 Milan, Italy. EPOCA Research Center for Clinical, Occupational and Environmental Epidemiology, Department of Occupational Medicine, University of Milan I-20122 Milan, Italy. Core Genotyping Facility, Advanced Technology Center, National Cancer Institute Gaithersburg, MD 20892, USA. Division of Cancer Epidemiology and Prevention, Cancer Center and M.Sklodowska-Curie Institute of Oncology 02-781 Warsaw, Poland. Department of Hepatic and Gastrointestinal Pathology, Armed Forces Institute of Pathology Washington, DC, 20306, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 118 EP - 123 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 28 IS - 1 SN - 0143-3334, 0143-3334 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Helicobacter pylori KW - Age KW - Helper cells KW - Genotyping KW - Gene polymorphism KW - Interleukin 1 KW - Statistical analysis KW - Population studies KW - Infection KW - Smoking KW - Single-nucleotide polymorphism KW - Risk factors KW - Carcinogenesis KW - Lymphocytes T KW - Tumor necrosis factor- alpha KW - genomics KW - Gastric cancer KW - Sex KW - G 07720:Immunogenetics KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19504316?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+Th1-type+cell-mediated+response+genes+and+risk+of+gastric+cancer&rft.au=Hou%2C+L%3BEl-Omar%2C+E+M%3BChen%2C+J%3BGrillo%2C+P%3BRabkin%2C+C+S%3BBaccarelli%2C+A%3BYeager%2C+M%3BChanock%2C+S+J%3BZatonski%2C+W%3BSobin%2C+L+H%3BLissowska%2C+J%3BFraumeni%2C+JFJr%3BChow%2C+W+H&rft.aulast=Hou&rft.aufirst=L&rft.date=2007-01-01&rft.volume=28&rft.issue=1&rft.spage=118&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Gene polymorphism; Genotyping; Helper cells; Interleukin 1; Statistical analysis; Population studies; Infection; Smoking; Single-nucleotide polymorphism; Risk factors; Carcinogenesis; Lymphocytes T; genomics; Tumor necrosis factor- alpha; Gastric cancer; Sex; Helicobacter pylori ER - TY - JOUR T1 - Engineering controllable anisotropy in electrospun biodegradable nanofibrous scaffolds for musculoskeletal tissue engineering AN - 19503803; 8792212 AB - Many musculoskeletal tissues exhibit significant anisotropic mechanical properties reflective of a highly oriented underlying extracellular matrix. For tissue engineering, recreating this organization of the native tissue remains a challenge. To address this issue, this study explored the fabrication of biodegradable nanofibrous scaffolds composed of aligned fibers via electrospinning onto a rotating target, and characterized their mechanical anisotropy as a function of the production parameters. The characterization showed that nanofiber organization was dependent on the rotation speed of the target; randomly oriented fibers (33% fiber alignment) were produced on a stationary shaft, whereas highly oriented fibers (94% fiber alignment) were produced when rotation speed was increased to 9.3 m/s. Non-aligned scaffolds had an isotropic tensile modulus of 2.1±0.4 MPa, compared to highly anisotropic scaffolds whose modulus was 11.6±3.1 MPa in the presumed fiber direction, suggesting that fiber alignment has a profound effect on the mechanical properties of scaffolds. Mechanical anisotropy was most pronounced at higher rotation speeds, with a greater than 33-fold enhancement of the Young's modulus in the fiber direction compared to perpendicular to the fiber direction when the rotation speed reached 8 m/s. In cell culture, both the organization of actin filaments of human mesenchymal stem cells and the cellular alignment of meniscal fibroblasts were dictated by the prevailing nanofiber orientation. This study demonstrates that controllable and anisotropic mechanical properties of nanofibrous scaffolds can be achieved by dictating nanofiber organization through intelligent scaffold design. JF - Journal of Biomechanics AU - Li, Wan-Ju AU - Mauck, Robert L AU - Cooper, James A AU - Yuan, Xiaoning AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA, tuanr@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 1686 EP - 1693 PB - Elsevier Science, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 40 IS - 8 SN - 0021-9290, 0021-9290 KW - Biotechnology and Bioengineering Abstracts KW - Tissue engineering KW - Tensile properties KW - Anisotropy KW - Mechanical testing KW - Biodegradable scaffolds KW - Cell culture KW - scaffolds KW - Fibroblasts KW - Fibers KW - Stem cells KW - Extracellular matrix KW - meniscus KW - Actin KW - Mesenchyme KW - Filaments KW - Mechanical properties KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19503803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomechanics&rft.atitle=Engineering+controllable+anisotropy+in+electrospun+biodegradable+nanofibrous+scaffolds+for+musculoskeletal+tissue+engineering&rft.au=Li%2C+Wan-Ju%3BMauck%2C+Robert+L%3BCooper%2C+James+A%3BYuan%2C+Xiaoning%3BTuan%2C+Rocky+S&rft.aulast=Li&rft.aufirst=Wan-Ju&rft.date=2007-01-01&rft.volume=40&rft.issue=8&rft.spage=1686&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomechanics&rft.issn=00219290&rft_id=info:doi/10.1016%2Fj.jbiomech.2006.09.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Anisotropy; Cell culture; Tissue engineering; scaffolds; Fibroblasts; Fibers; Stem cells; meniscus; Extracellular matrix; Actin; Mesenchyme; Filaments; Mechanical properties DO - http://dx.doi.org/10.1016/j.jbiomech.2006.09.004 ER - TY - JOUR T1 - Stem cells of the melanocyte lineage AN - 19499419; 8718907 AB - Melanocytes are pigment-producing cells responsible for coloration of skin and hair. Studies using mouse models have allowed identification of putative melanocyte stem cells within the hair follicle and understanding of hair graying caused by abnormal melanocyte stem cell maintenance. The malignant transformation of melanocytes results in melanoma, the sixth most common cancer in the United States. Recent studies have offered compelling evidence for the existence of cancer stem cells in numerous tumor types, including melanoma. In this review we provide an overview of some of the current findings on follicular melanocyte stem cells, the genetic pathways involved in their regulation and maintenance, and discuss recent studies that support the existence of cancer stem cells in melanoma. JF - Cancer Biomarkers AU - Pavan, William J AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health Bethesda, MD 20892-4472, USA Y1 - 2007 PY - 2007 DA - 2007 SP - 203 EP - 209 PB - IOS Press, Nieuwe Hemweg 6B VL - 3 IS - 4,5 SN - 1574-0153, 1574-0153 KW - Biotechnology and Bioengineering Abstracts KW - Melanocyte stem cells KW - melanoma KW - cancer stem cells KW - Transformation KW - Skin KW - Follicles KW - Animal models KW - Melanocytes KW - Tumors KW - Hair KW - Cancer KW - Melanoma KW - Stem cells KW - Coloration KW - Reviews KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19499419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Cancer+Biomarkers&rft.atitle=Stem+cells+of+the+melanocyte+lineage&rft.au=Pavan%2C+William+J&rft.aulast=Pavan&rft.aufirst=William&rft.date=2007-01-01&rft.volume=3&rft.issue=4%2C5&rft.spage=203&rft.isbn=&rft.btitle=&rft.title=Cancer+Biomarkers&rft.issn=15740153&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Transformation; Stem cells; Skin; Coloration; Follicles; Reviews; Animal models; Tumors; Melanocytes; Hair; Cancer; Melanoma ER - TY - JOUR T1 - Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome AN - 19492216; 7186088 AB - One goal in sequencing the Plasmodium falciparum genome, the agent of the most lethal form of malaria, is to discover vaccine and drug targets super(1). However, identifying those targets in a genome in which [math]60% of genes have unknown functions is an enormous challenge. Because the majority of known malaria antigens and drug-resistant genes are highly polymorphic and under various selective pressures super(2, ) super(3, ) super(4, ) super(5, ) super(6), genome-wide analysis for signatures of selection may lead to discovery of new vaccine and drug candidates. Here we surveyed 3,539 P. falciparum genes ([math]65% of the predicted genes) for polymorphisms and identified various highly polymorphic loci and genes, some of which encode new antigens that we confirmed using human immune sera. Our collections of genome-wide SNPs ([math]65% nonsynonymous) and polymorphic microsatellites and indels provide a high-resolution map (one marker per [math]4 kb) for mapping parasite traits and studying parasite populations. In addition, we report new antigens, providing urgently needed vaccine candidates for disease control. JF - Nature Genetics AU - Mu, Jianbing AU - Awadalla, Philip AU - Duan, Junhui AU - McGee, Kate M AU - Keebler, Jon AU - Seydel, Karl AU - McVean, Gilean A T AU - Su, Xin-Zhuan AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., xsu@niaid.nih.gov Y1 - 2007/01// PY - 2007 DA - January 2007 SP - 126 EP - 130 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com] VL - 39 IS - 1 SN - 1061-4036, 1061-4036 KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts C: Algology, Mycology & Protozoology; Genetics Abstracts KW - Genomes KW - Parasites KW - Human diseases KW - Gene polymorphism KW - Drug resistance KW - Microsatellites KW - Disease control KW - Drug development KW - Malaria KW - Plasmodium falciparum KW - Biopolymorphism KW - Public health KW - Single-nucleotide polymorphism KW - Vaccines KW - Drugs KW - Gene mapping KW - G 07790:Other Microorganisms KW - Q1 08484:Species interactions: parasites and diseases KW - Q5 08524:Public health, medicines, dangerous organisms KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19492216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Genome-wide+variation+and+identification+of+vaccine+targets+in+the+Plasmodium+falciparum+genome&rft.au=Mu%2C+Jianbing%3BAwadalla%2C+Philip%3BDuan%2C+Junhui%3BMcGee%2C+Kate+M%3BKeebler%2C+Jon%3BSeydel%2C+Karl%3BMcVean%2C+Gilean+A+T%3BSu%2C+Xin-Zhuan&rft.aulast=Mu&rft.aufirst=Jianbing&rft.date=2007-01-01&rft.volume=39&rft.issue=1&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/10.1038%2Fng1924 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Genomes; Parasites; Human diseases; Disease control; Malaria; Vaccines; Biopolymorphism; Drugs; Public health; Single-nucleotide polymorphism; Drug resistance; Gene polymorphism; Microsatellites; Drug development; Gene mapping; Plasmodium falciparum DO - http://dx.doi.org/10.1038/ng1924 ER - TY - JOUR T1 - A second-generation autologous chondrocyte implantation approach to the treatment of focal articular cartilage defects AN - 19487053; 8522243 AB - Autologous chondrocyte implantation (ACI) is the most widely used cell-based surgical procedure for the repair of articular cartilage defects. Challenges to successful ACI outcomes include limitation in defect size and geometry as well as inefficient cell retention. Second-generation ACI procedures have thus focused on developing three-dimensional constructs using native and synthetic biomaterials. Clinically significant and satisfactory results from applying autologous chondrocytes seeded in fibrin within a biodegradable polymeric material were recently reported. In the future, third-generation cell-based articular cartilage repair should focus on the use of chondroprogenitor cells and biofunctionalized biomaterials for more extensive and permanent repair. JF - Arthritis Research & Therapy AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA, tuanr@mail.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 109 PB - BioMed Central Ltd., Middlesex House VL - 9 IS - 5 SN - 1478-6354, 1478-6354 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - fibrin KW - Biomaterials KW - Chondrocytes KW - Cartilage (articular) KW - T 2030:Cartilage and Cartilage Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19487053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Arthritis+Research+%26+Therapy&rft.atitle=A+second-generation+autologous+chondrocyte+implantation+approach+to+the+treatment+of+focal+articular+cartilage+defects&rft.au=Tuan%2C+Rocky+S&rft.aulast=Tuan&rft.aufirst=Rocky&rft.date=2007-01-01&rft.volume=9&rft.issue=5&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Arthritis+Research+%26+Therapy&rft.issn=14786354&rft_id=info:doi/10.1186%2Far2310 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - fibrin; Biomaterials; Chondrocytes; Cartilage (articular) DO - http://dx.doi.org/10.1186/ar2310 ER - TY - JOUR T1 - Investigating emotion in moral cognition: a review of evidence from functional neuroimaging and neuropsychology AN - 19485687; 8510339 AB - Introduction Human moral decision-making has long been a topic of philosophical debate, and, more recently, a topic for empirical investigation. Central to this investigation is the extent to which emotional processes underlie our decisions about moral right and wrong. Neuroscience offers a unique perspective on this question by addressing whether brain regions associated with emotional processing are involved in moral cognition.Method We conduct a narrative review of neuroscientific studies focused on the role of emotion in morality. Specifically, we describe evidence implicating the ventromedial prefrontal cortex (VMPC), a brain region known to be important for emotional processing.Results Functional imaging studies demonstrate VMPC activation during tasks probing moral cognition. Studies of clinical populations, including patients with VMPC damage, reveal an association between impairments in emotional processing and impairments in moral judgement and behaviour.Conclusions Considered together, these studies indicate that not only are emotions engaged during moral cognition, but that emotions, particularly those mediated by VMPC, are in fact critical for human morality. JF - British Medical Bulletin AU - Young, Liane AU - Koenigs, Michael AD - Department of Psychology , Harvard University , 33 Kirkland Street, 984 William James Hall, Cambridge, MA 02138 , USA,; koenigsm@ninds.nih.gov] lyoung@fas.harvard.edu Y1 - 2007 PY - 2007 DA - 2007 SP - 69 EP - 79 PB - Oxford University Press, Oxford Journals, Great Clarendon Street VL - 84 IS - 1 SN - 0007-1420, 0007-1420 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroscience KW - emotion KW - morality KW - ventromedial prefrontal cortex KW - Emotions KW - Decision making KW - Neuroimaging KW - Ethics KW - Computed tomography KW - Population studies KW - Cognition KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19485687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Medical+Bulletin&rft.atitle=Investigating+emotion+in+moral+cognition%3A+a+review+of+evidence+from+functional+neuroimaging+and+neuropsychology&rft.au=Young%2C+Liane%3BKoenigs%2C+Michael&rft.aulast=Young&rft.aufirst=Liane&rft.date=2007-01-01&rft.volume=84&rft.issue=1&rft.spage=69&rft.isbn=&rft.btitle=&rft.title=British+Medical+Bulletin&rft.issn=00071420&rft_id=info:doi/10.1093%2Fbmb%2Fldm031 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-10-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Decision making; Emotions; Neuroimaging; Ethics; Computed tomography; Population studies; Cortex (prefrontal); Cognition DO - http://dx.doi.org/10.1093/bmb/ldm031 ER - TY - JOUR T1 - Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract AN - 19480728; 7174092 AB - Kava (Piper methysticum), used for relaxation and pain relief, has been one of the leading dietary supplements and several reports linking hepatic functional disturbances and liver failure to kava have resulted in a ban on sales in Europe and Canada and the issuance of warnings by the US FDA. The National Toxicology Program conducted 14-week rat studies to characterize the toxicology of kava exposure in Fischer 344 rats [National Toxicity Program. 90 day gavage toxicity studies of KAVA KAVA EXTRACT in Fischer rats and B6C3F1 mice. Research Triangle Park, NC; 2005a; National Toxicity Program. Testing status of agents at NTP (KAVA KAVA EXTRACT M990058). Research Triangle Park, NC; 2005b. (http://ntp.niehs.nih.gov/index.cfm?objectid=071516E-C6E1-7AAA- C90C751E23D14C1B)]. Groups of 10 male and 10 female rats were administered kava extract by gavage at 0, 0.125, 0.25, 0.5, 1.0, and 2.0 g/kg/day. Increased gamma -glutamyl-transpeptidase (GGT) activities were observed in the 2.0 g/kg males and 1.0 and 2.0 g/kg females, as well as increased serum cholesterol levels in males and females at 0.5 g/kg and higher. Increases in incidence and severity of hepatocellular hypertrophy (HP) were noted in males at 1.0 g/kg and females at 0.5 g/kg and higher, as well as increased liver weights. Immunohistochemical analyses of the expression of cytochrome-P450 (CYP) enzymes in liver of the control and 1.0- and 2.0-g/kg-treated groups indicated decreased expression of CYP2D1 (human CYP2D6 homolog) in 2.0 g/kg females and increased expression of CYP1A2, 2B1, and 3A1 in 1.0 and 2.0 g/kg groups of both sexes. The no observed adverse effect levels were decided as 0.25 g/kg in both genders, based on neurotoxic effects, increases in GGT, cholesterol, liver weight, and HP and decreases in body weight. Kava-induced hepatic functional changes in the F344 rat might be relevant to human clinical cases of hepatotoxicity following exposure. JF - Experimental and Toxicologic Pathology AU - Clayton, Natasha P AU - Yoshizawa, Katsuhiko AU - Kissling, Grace E AU - Burka, Leo T AU - Chan, Po-Chuen AU - Nyska, Abraham AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA, anyska@bezeqint.net Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 223 EP - 236 PB - Elsevier GmbH, Office Jena, P.O. Box 100537 Jena D-07705 Germany, [mailto:journals@elsevier.com], [URL:http://www.elsevier.de/] VL - 58 IS - 4 SN - 0940-2993, 0940-2993 KW - Toxicology Abstracts KW - Kava KW - Piper methysticum KW - Herb KW - Hepatocellular hypertrophy KW - Cytochrome P450 KW - F344 rat KW - Liver diseases KW - Enzymes KW - Pain KW - Cholesterol KW - Toxicity KW - hepatotoxicity KW - Hypertrophy KW - Body weight KW - Dietary supplements KW - Neurotoxicity KW - Parks KW - Liver KW - Side effects KW - CYP2D6 protein KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19480728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+and+Toxicologic+Pathology&rft.atitle=Immunohistochemical+analysis+of+expressions+of+hepatic+cytochrome+P450+in+F344+rats+following+oral+treatment+with+kava+extract&rft.au=Clayton%2C+Natasha+P%3BYoshizawa%2C+Katsuhiko%3BKissling%2C+Grace+E%3BBurka%2C+Leo+T%3BChan%2C+Po-Chuen%3BNyska%2C+Abraham&rft.aulast=Clayton&rft.aufirst=Natasha&rft.date=2007-01-01&rft.volume=58&rft.issue=4&rft.spage=223&rft.isbn=&rft.btitle=&rft.title=Experimental+and+Toxicologic+Pathology&rft.issn=09402993&rft_id=info:doi/10.1016%2Fj.etp.2006.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Liver diseases; Enzymes; Pain; Toxicity; Cholesterol; hepatotoxicity; Hypertrophy; Body weight; Dietary supplements; Neurotoxicity; Liver; Parks; Cytochrome P450; Side effects; CYP2D6 protein; Piper methysticum DO - http://dx.doi.org/10.1016/j.etp.2006.08.002 ER - TY - JOUR T1 - Mapping the MRI voxel volume in which thermal noise matches physiological noise - Implications for fMRI AN - 19476834; 7162232 AB - This work addresses the choice of the imaging voxel volume in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). Noise of physiological origin that is present in the voxel time course is a prohibitive factor in the detection of small activation-induced BOLD signal changes. If the physiological noise contribution dominates over the temporal fluctuation contribution in the imaging voxel, further increases in the voxel signal-to- noise ratio (SNR) will have diminished corresponding increases in temporal signal-to-noise (TSNR), resulting in reduced corresponding increases in the ability to detect activation induced signal changes. On the other hand, if the thermal and system noise dominate (suggesting a relatively low SNR) further decreases in SNR can prohibit detection of activation-induced signal changes. Here we have proposed and called the "suggested" voxel volume for fMRI the volume where thermal plus system-related and physiological noise variances are equal. Based on this condition we have created maps of fMRI suggested voxel volume from our experimental data at 3T, since this value will spatially vary depending on the contribution of physiologic noise in each voxel. Based on our fast EPI segmentation technique we have found that for gray matter (GM), white matter (WM), and cerebral spinal fluid (CSF) brain compartments the mean suggested cubical voxel volume is: (1.8 mm) super(3), (2.1 mm) super(3) and (1.4 mm) super(3), respectively. Serendipitously, (1.8 mm) super(3) cubical voxel volume for GM approximately matches the cortical thickness, thus optimizing BOLD contrast by minimizing partial volume averaging. The introduced suggested fMRI voxel volume can be a useful parameter for choice of imaging volume for functional studies. JF - NeuroImage AU - Bodurka, J AU - Ye, F AU - Petridou, N AU - Murphy, K AU - Bandettini, P A AD - Functional MRI Facility, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), 10 Center Drive, Building 10, Room 1D80, Bethesda, MD 20892-1148, USA, bodurkaj@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 542 EP - 549 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Functional magnetic resonance imaging KW - Brain KW - Image processing KW - Substantia alba KW - Maps KW - Cerebrospinal fluid KW - Cortex KW - Segmentation KW - Mapping KW - Substantia grisea KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19476834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Mapping+the+MRI+voxel+volume+in+which+thermal+noise+matches+physiological+noise+-+Implications+for+fMRI&rft.au=Bodurka%2C+J%3BYe%2C+F%3BPetridou%2C+N%3BMurphy%2C+K%3BBandettini%2C+P+A&rft.aulast=Bodurka&rft.aufirst=J&rft.date=2007-01-01&rft.volume=34&rft.issue=2&rft.spage=542&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.09.039 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Neuroimaging; Cerebrospinal fluid; Maps; Substantia alba; Brain; Substantia grisea; Segmentation; Image processing; Mapping; Cortex DO - http://dx.doi.org/10.1016/j.neuroimage.2006.09.039 ER - TY - JOUR T1 - Neural dynamics for facial threat processing as revealed by gamma band synchronization using MEG AN - 19473799; 7162255 AB - Facial threat conveys important information about imminent environmental danger. The rapid detection of this information is critical for survival and social interaction. However, due to technical and methodological difficulties, the spatiotemporal profile for facial threat processing is unknown. By utilizing magnetoencephalography (MEG), a brain-imaging technique with superb temporal resolution and fairly good spatial resolution, Synthetic Aperture Magnetometry (SAM), a recently developed source analysis technique, and a sliding window analysis, we identified the spatiotemporal development of facial threat processing in the gamma frequency band. We also tested the dual-route hypothesis by LeDoux who proposed, based on animal research, that there are two routes to the amygdala: a quick subcortical route and a slower and cortical route. Direct evidence with humans supporting this model has been lacking. Moreover, it has been unclear whether the subcortical route responds specifically to fearful expressions or to threatening expressions in general. We found early event- related synchronizations (ERS) in response to fearful faces in the hypothalamus/thalamus area (10-20 ms) and then the amygdala (20-30 ms). This was even earlier than the ERS response seen to fearful faces in visual cortex (40-50 ms). These data support LeDouxs suggestion of a quick, subcortical thamalo- amygdala route. Moreover, this route was specific for fear expressions; the ERS response in the amygdala to angry expressions had a late onset (150-160 ms). The ERS onset in prefrontal cortex followed that seen within the amygdala (around 160-210 ms). This is consistent with its role in higher-level emotional/cognitive processing. JF - NeuroImage AU - Luo, Qian AU - Holroyd, Tom AU - Jones, Matthew AU - Hendler, Talma AU - Blair, James AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-2670, USA, luoj@mail.nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 839 EP - 847 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetoencephalography KW - Emotions KW - Fear KW - Synchronization KW - Survival KW - Thalamus KW - Cortex KW - Information processing KW - Social interactions KW - Cognitive ability KW - Cortex (visual) KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19473799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Neural+dynamics+for+facial+threat+processing+as+revealed+by+gamma+band+synchronization+using+MEG&rft.au=Luo%2C+Qian%3BHolroyd%2C+Tom%3BJones%2C+Matthew%3BHendler%2C+Talma%3BBlair%2C+James&rft.aulast=Luo&rft.aufirst=Qian&rft.date=2007-01-01&rft.volume=34&rft.issue=2&rft.spage=839&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.09.023 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Amygdala; Cortex (prefrontal); Synchronization; Cortex (visual); Emotions; Social interactions; Survival; Information processing; Thalamus; Cognitive ability; Magnetoencephalography; Cortex; Fear DO - http://dx.doi.org/10.1016/j.neuroimage.2006.09.023 ER - TY - JOUR T1 - Environmental Exposure and Children's Health in China AN - 19473340; 8127903 AB - Concerns regarding adverse health effects of exposure to environmental pollutants among children are increasing. This subject area is particularly important in China because of environmental pollution problems associated with rapid development and a large population. The authors provide what is, to their knowledge, the first review in China of English- and Chinese-language literature regarding the current status of environmental exposures to children in China and the impact of these exposures on the health of children. Children in China are exposed to diverse environmental pollutants, including traditional pollutants such as lead and mercury and emerging pollutants such as phthalates and perfluorinated compounds. Incidence and prevalence of certain childhood diseases have increased in last decades. In China, a limited number of data on environmental exposure and children's health are available, and further high-quality studies are needed. JF - Archives of Environmental and Occupational Health AU - Ye, X AU - Fu, H AU - Guidotti, T AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), 111 TW Alexander Dr, MD A305, Research Triangle Park, NC 27709, USA, yex2@niehs.nih.gov Y1 - 2007 PY - 2007 DA - 2007 SP - 61 EP - 73 VL - 62 IS - 2 SN - 1933-8244, 1933-8244 KW - Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Environmental health KW - Pollution effects KW - Children KW - Lead KW - Phthalic acid KW - phthalates KW - Pollutants KW - Reviews KW - Mercury KW - China, People's Rep. KW - Pollution KW - X 24360:Metals KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19473340?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+Environmental+and+Occupational+Health&rft.atitle=Environmental+Exposure+and+Children%27s+Health+in+China&rft.au=Ye%2C+X%3BFu%2C+H%3BGuidotti%2C+T&rft.aulast=Ye&rft.aufirst=X&rft.date=2007-01-01&rft.volume=62&rft.issue=2&rft.spage=61&rft.isbn=&rft.btitle=&rft.title=Archives+of+Environmental+and+Occupational+Health&rft.issn=19338244&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Pollutants; Reviews; Mercury; Children; Pollution; Phthalic acid; phthalates; Pollution effects; Environmental health; Lead; China, People's Rep. ER - TY - JOUR T1 - How long to scan? The relationship between fMRI temporal signal to noise ratio and necessary scan duration AN - 19470958; 7162234 AB - Recent advances in MRI receiver and coil technologies have significantly improved image signal-to-noise ratios (SNR) and thus temporal SNR (TSNR). These gains in SNR and TSNR have allowed the detection of fMRI signal changes at higher spatial resolution and therefore have increased the potential to localize small brain structures such as cortical layers and columns. The majority of current fMRI processing strategies employ multi-subject averaging and therefore require spatial smoothing and normalization, effectively negating these gains in spatial resolution higher than about 10 mm super(3). Reliable detection of activation in single subjects at high resolution is becoming a more common desire among fMRI researchers who are interested in comparing individuals rather than populations. Since TSNR decreases with voxel volume, detection of activation at higher resolutions requires longer scan durations. The relationship between TSNR, voxel volume and detectability is highly non-linear. In this study, the relationship between TSNR and the necessary fMRI scan duration required to obtain significant results at varying P values is determined both experimentally and theoretically. The results demonstrate that, with a TSNR of 50, detection of activation of above 2% requires at most 350 scan volumes (when steps are taken to remove the influence of physiological noise from the data). Importantly, these results also demonstrate that, for activation magnitude on the order of 1%, the scan duration required is more sensitive to the TSNR level than at 2%. This study showed that with voxel volumes of 10 mm super(3) at 3 T, and a corresponding TSNR of 50, the required number of time points that guarantees detection of signal changes of 1% is about 860, but if TSNR increases by only 20%, the time for detection decreases by more than 30%. More than just being an exercise in numbers, these results imply that imaging of columnar resolution (effect size = 1% and assuming a TR of 1 s) at 3 T will require either 10 min for a TSNR of 60 or 40 min for a TSNR of 30. The implication is that at these resolutions, TSNR is likely to be critical for determining success or failure of an experiment. JF - NeuroImage AU - Murphy, Kevin AU - Bodurka, Jerzy AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, National Institute of Mental Health, NIH, Bethesda, MD 20892-1148, USA, bandettini@nih.gov Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - 565 EP - 574 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 34 IS - 2 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Cortex KW - Functional magnetic resonance imaging KW - Brain KW - Physical training KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19470958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=How+long+to+scan%3F+The+relationship+between+fMRI+temporal+signal+to+noise+ratio+and+necessary+scan+duration&rft.au=Murphy%2C+Kevin%3BBodurka%2C+Jerzy%3BBandettini%2C+Peter+A&rft.aulast=Murphy&rft.aufirst=Kevin&rft.date=2007-01-01&rft.volume=34&rft.issue=2&rft.spage=565&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.09.032 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Neuroimaging; Cortex; Brain; Physical training DO - http://dx.doi.org/10.1016/j.neuroimage.2006.09.032 ER - TY - JOUR T1 - MMDB: annotating protein sequences with Entrez's 3D-structure database AN - 19463495; 7254418 AB - Three-dimensional (3D) structure is now known for a large fraction of all protein families. Thus, it has become rather likely that one will find a homolog with known 3D structure when searching a sequence database with an arbitrary query sequence. Depending on the extent of similarity, such neighbor relationships may allow one to infer biological function and to identify functional sites such as binding motifs or catalytic centers. Entrez's 3D-structure database, the Molecular Modeling Database (MMDB), provides easy access to the richness of 3D structure data and its large potential for functional annotation. Entrez's search engine offers several tools to assist biologist users: (i) links between databases, such as between protein sequences and structures, (ii) pre-computed sequence and structure neighbors, (iii) visualization of structure and sequence/structure alignment. Here, we describe an annotation service that combines some of these tools automatically, Entrez's 'Related Structure' links. For all proteins in Entrez, similar sequences with known 3D structure are detected by BLAST and alignments are recorded. The 'Related Structure' service summarizes this information and presents 3D views mapping sequence residues onto all 3D structures available in MMDB (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=structure). JF - Nucleic Acids Research AU - Wang, Yanli AU - Addess, Kenneth J AU - Chen, Jie AU - Geer, Lewis Y AU - He, Jane AU - He, Siqian AU - Lu, Shennan AU - Madej, Thomas AU - Marchler-Bauer, Aron AU - Thiessen, Paul A AU - Zhang, Naigong AU - Bryant, Stephen H AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA Y1 - 2007/01// PY - 2007 DA - Jan 2007 SP - D298 EP - D300 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 35 SN - 0305-1048, 0305-1048 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Molecular modelling KW - Databases KW - protein families KW - N 14845:Miscellaneous KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=MMDB%3A+annotating+protein+sequences+with+Entrez%27s+3D-structure+database&rft.au=Wang%2C+Yanli%3BAddess%2C+Kenneth+J%3BChen%2C+Jie%3BGeer%2C+Lewis+Y%3BHe%2C+Jane%3BHe%2C+Siqian%3BLu%2C+Shennan%3BMadej%2C+Thomas%3BMarchler-Bauer%2C+Aron%3BThiessen%2C+Paul+A%3BZhang%2C+Naigong%3BBryant%2C+Stephen+H&rft.aulast=Wang&rft.aufirst=Yanli&rft.date=2007-01-01&rft.volume=35&rft.issue=&rft.spage=D298&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Databases; Molecular modelling; protein families ER - TY - JOUR T1 - Assessing the efficacy, effectiveness, and cost-effectiveness of assistive technology interventions for enhancing mobility AN - 1347817020; 201306144 AB - Purpose. The aim of this paper is to highlight the contributions that complementary efficacy, effectiveness, and cost-effectiveness studies can make to assessing the outcomes of assistive technology interventions for enhancing mobility. Method. The terms, 'assistive technology outcomes research' and 'assistive technology interventions', are defined. Several bases are examined for the shortage of outcomes research pertaining to mobility-related assistive technology interventions. Three presuppositions are described for the research strategy of interlocking studies being recommended. They are assigning priority to evaluating both recently developed assistive technologies and ones that have long been available, acknowledging the complexity of assistive technology as an intervention, and appreciating the trade-offs necessary for strengthening studies' internal and external validity. Some key study preparations are considered, including treatment theory, treatment specification, and the selection of outcome domains and measures. The essential features of efficacy, effectiveness, and cost-effectiveness studies are outlined, and their interdependence is stressed. Results and Conclusions. To assess the outcomes of assistive technology interventions for mobility in ways that are both methodologically sound and relevant to stakeholder needs, a research strategy is required involving mutually reinforcing efficacy, effectiveness, and cost-effectiveness studies. Collaborative arrangements and funding methods are discussed for fostering the needed research. Adapted from the source document. JF - Disability and Rehabilitation: Assistive Technology AU - Fuhrer, Marcus J AD - National Center for Medical Rehabilitation Research, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA fuhrerm@mail.nih.gov Y1 - 2007///0, PY - 2007 DA - 0, 2007 SP - 149 EP - 158 PB - Informa HealthCare, Abingdon UK VL - 2 IS - 3 SN - 1748-3107, 1748-3107 KW - Assistive technology, mobility, outcomes research, efficacy, effectiveness, cost-effectiveness KW - Mobility KW - Efficacy KW - Interventions KW - Specification KW - Cost effectiveness KW - Technical aids KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1347817020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.atitle=Assessing+the+efficacy%2C+effectiveness%2C+and+cost-effectiveness+of+assistive+technology+interventions+for+enhancing+mobility&rft.au=Fuhrer%2C+Marcus+J&rft.aulast=Fuhrer&rft.aufirst=Marcus&rft.date=2007-01-01&rft.volume=2&rft.issue=3&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Disability+and+Rehabilitation%3A+Assistive+Technology&rft.issn=17483107&rft_id=info:doi/10.1080%2F17483100701374355 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2013-05-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Technical aids; Interventions; Cost effectiveness; Efficacy; Mobility; Specification DO - http://dx.doi.org/10.1080/17483100701374355 ER - TY - JOUR T1 - New psittacosaurid highlights skull enlargement in horned dinosaurs AN - 1244669552; 2013-006285 AB - Anew psittacosaurid is based on a nearly complete articulated skeleton from northeastern China that differs principally in skull size as compared to the most common and widespread species, Psittacosaurus mongoliensis. The skull of Psittacosaurus major sp. nov., is 25% larger despite very similar postcranial skeletal dimensions. Such selective skull enlargement is very unusual. Skull size in ceratopsians, in general, scales with positive allometry relative to body mass: species of greater mass have proportionately larger skulls. This pattern stands in marked contrast to that for other vertebrate herbivores, in which larger-bodied species either have proportionately similar or smaller skulls relative to body mass. Larger-bodied ceratopsians evolved skulls that are 50% or more of trunk length-as measured without their expansive cranial frill. Although contemporaneous duck-billed dinosaurs also exhibit some positive allometry in the skull, skull length remains approximately 35% of trunk length. The evolution of extraordinary absolute and relative skull size among ceratopsians appears to have been driven by sexual selection and involved the tandem evolution of reduced head mobility and an obligate quadrupedal posture. JF - Acta Palaeontologica Polonica AU - Sereno, Paul C AU - Zhao, Xijin AU - Brown, Lorin AU - Tan, Lin Y1 - 2007 PY - 2007 DA - 2007 SP - 275 EP - 284 PB - Panstwowe Wydawnictwo Naukowe, Warsaw VL - 52 IS - 2 SN - 0567-7920, 0567-7920 KW - Diapsida KW - Far East KW - Psittacosaurus major KW - Cretaceous KW - northeastern China KW - Liaoning China KW - new taxa KW - Psittacosauridae KW - Archosauria KW - skull KW - Ceratopsia KW - upper Mesozoic KW - Psittacosaurus KW - dinosaurs KW - taxonomy KW - Asia KW - China KW - Chordata KW - Beipiao China KW - Mesozoic KW - Reptilia KW - Yixian Formation KW - Marginocephalia KW - Vertebrata KW - Ornithischia KW - Tetrapoda KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1244669552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+Palaeontologica+Polonica&rft.atitle=New+psittacosaurid+highlights+skull+enlargement+in+horned+dinosaurs&rft.au=Sereno%2C+Paul+C%3BZhao%2C+Xijin%3BBrown%2C+Lorin%3BTan%2C+Lin&rft.aulast=Sereno&rft.aufirst=Paul&rft.date=2007-01-01&rft.volume=52&rft.issue=2&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=Acta+Palaeontologica+Polonica&rft.issn=05677920&rft_id=info:doi/ L2 - http://www.app.pan.pl/archive/published/app52/app52-275.pdf http://app.pan.pl/ LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2013, American Geosciences Institute. Reference includes data supplied by Panstwowy Instytut Geologiczny, Warsaw, Poland N1 - Date revised - 2013-01-01 N1 - Number of references - 52 N1 - Document feature - illus. incl. 3 tables N1 - SuppNotes - Accessed on Dec. 14, 2012 N1 - Last updated - 2012-12-27 N1 - CODEN - APGPAC N1 - SubjectsTermNotLitGenreText - Archosauria; Asia; Beipiao China; Ceratopsia; China; Chordata; Cretaceous; Diapsida; dinosaurs; Far East; Liaoning China; Marginocephalia; Mesozoic; new taxa; northeastern China; Ornithischia; Psittacosauridae; Psittacosaurus; Psittacosaurus major; Reptilia; skull; taxonomy; Tetrapoda; upper Mesozoic; Vertebrata; Yixian Formation ER - TY - JOUR T1 - Reduced repair of 8-hydroxyguanine in the human breast cancer cell line, HCC1937. AN - 68295031; 17192190 AB - Breast cancer is the second leading cause of cancer deaths in women in the United States. Although the causes of this disease are incompletely understood, oxidative DNA damage is presumed to play a critical role in breast carcinogenesis. A common oxidatively induced DNA lesion is 8-hydroxyguanine (8-OH-Gua), which has been implicated in carcinogenesis. The aim of this study was to investigate the ability of HCC1937 and MCF-7 breast cancer cell lines to repair 8-OH-Gua relative to a nonmalignant human mammary epithelial cell line, AG11134. We used oligonucleotide incision assay to analyze the ability of the two breast cancer cell lines to incise 8-OH-Gua relative to the control cell line. Liquid chromatography/mass spectrometry (LC/MS) was used to measure the levels of 8-OH-Gua as its nucleoside, 8-OH-dG in the cell lines after exposure to H2O2 followed by 30 min repair period. Protein expression levels were determined by Western blot analysis, while the hOGG1 mRNA levels were analyzed by RT-PCR. Complementation of hOGG1 activity in HCC1937 cells was assessed by addition of the purified protein in the incision assay, and in vivo by transfection of pFlagCMV-4-hOGG1. Clonogenic survival assay was used to determine sensitivity after H2O2-mediated oxidative stress. We show that the HCC1937 breast cancer cells have diminished ability to incise 8-OH-Gua and they accumulate higher levels of 8-OH-dG in the nuclear genome after H2O2 treatment despite a 30 min repair period when compared to the nonmalignant mammary cells. The defective incision of 8-OH-Gua was consistent with expression of undetectable amounts of hOGG1 in HCC1937 cells. The reduced incision activity was significantly stimulated by addition of purified hOGG1. Furthermore, transfection of pFlagCMV-4-hOGG1 in HCC1937 cells resulted in enhanced incision of 8-OH-Gua. HCC1937 cells are more sensitive to high levels of H2O2 and have up-regulated SOD1 and SOD2. This study provides evidence for inefficient repair of 8-OH-Gua in HCC1937 breast cancer cell line and directly implicates hOGG1 in this defect. JF - BMC cancer AU - Nyaga, Simon G AU - Lohani, Althaf AU - Jaruga, Pawel AU - Trzeciak, Andrzej R AU - Dizdaroglu, Miral AU - Evans, Michele K AD - Laboratory of Cellular and Molecular Biology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA. nyagas@grc.nia.nih.gov Y1 - 2006/12/27/ PY - 2006 DA - 2006 Dec 27 SP - 297 VL - 6 KW - Cell Extracts KW - 0 KW - DNA Primers KW - Oligodeoxyribonucleotides KW - RNA, Neoplasm KW - 8-hydroxyguanine KW - 5614-64-2 KW - Guanine KW - 5Z93L87A1R KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Mitochondria -- physiology KW - DNA Repair KW - Carcinoma, Ductal -- genetics KW - Cell Nucleus -- ultrastructure KW - Humans KW - Hydrogen Peroxide -- pharmacology KW - Cell Line, Tumor KW - RNA, Neoplasm -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Extracts -- isolation & purification KW - Base Sequence KW - RNA, Neoplasm -- isolation & purification KW - Mitochondria -- ultrastructure KW - Transfection KW - Cell Nucleus -- physiology KW - Female KW - Breast Neoplasms -- genetics KW - Guanine -- analogs & derivatives KW - Guanine -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68295031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Reduced+repair+of+8-hydroxyguanine+in+the+human+breast+cancer+cell+line%2C+HCC1937.&rft.au=Nyaga%2C+Simon+G%3BLohani%2C+Althaf%3BJaruga%2C+Pawel%3BTrzeciak%2C+Andrzej+R%3BDizdaroglu%2C+Miral%3BEvans%2C+Michele+K&rft.aulast=Nyaga&rft.aufirst=Simon&rft.date=2006-12-27&rft.volume=6&rft.issue=&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-02 N1 - Date created - 2007-01-17 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: FASEB J. 2003 Apr;17(6):668-74 [12665480] J Bacteriol. 1992 Oct;174(20):6321-5 [1328155] Toxicol Sci. 2003 Sep;75(1):74-81 [12805649] Mutat Res. 2003 Oct 29;531(1-2):231-51 [14637258] J Biol Chem. 2003 Dec 26;278(52):52914-8 [14578343] Nucleic Acids Res. 2004;32(11):e87 [15215337] Carcinogenesis. 2004 Aug;25(8):1359-70 [15044326] Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5 [10557315] Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61 [10725358] Nucleic Acids Res. 2000 Jul 15;28(14):2672-8 [10908322] Nucleic Acids Res. 2001 Jan 15;29(2):430-8 [11139613] Nucleic Acids Res. 2001 Mar 15;29(6):1285-92 [11238994] Mutat Res. 2001 Jun 5;486(1):31-40 [11356334] Carcinogenesis. 2001 Sep;22(9):1459-63 [11532868] Mol Carcinog. 2001 Aug;31(4):214-23 [11536371] Prog Nucleic Acid Res Mol Biol. 2001;68:193-205 [11554297] Cancer. 1993 May 15;71(10):3036-43 [8387875] Trends Genet. 1993 Jul;9(7):246-9 [8379000] Mutat Res. 1995 May;336(3):257-67 [7739614] Nat Genet. 1996 Jul;13(3):266-8 [8673121] Br J Cancer. 1996 Jul;74(1):1-5 [8679441] Curr Biol. 1996 Aug 1;6(8):968-80 [8805338] FEBS Lett. 1997 Jan 2;400(1):25-30 [9000507] FASEB J. 1997 Jan;11(1):68-76 [9034168] Mol Gen Genet. 1997 Mar 26;254(2):171-8 [9108279] Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7429-34 [9207108] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8010-5 [9223305] Cancer Res. 1998 Aug 1;58(15):3237-42 [9699648] J Biol Chem. 1998 Dec 11;273(50):33811-6 [9837971] Oncogene. 1998 Dec 17;17(24):3115-24 [9872327] Nucleic Acids Res. 1999 Mar 1;27(5):1365-8 [9973627] J Biol Chem. 1999 Jun 25;274(26):18808-12 [10373498] Nucleic Acids Res. 1999 Oct 15;27(20):4001-7 [10497264] Biochemistry. 2004 Dec 21;43(50):15909-14 [15595846] Oncogene. 2005 Jun 30;24(28):4496-508 [15856018] FASEB J. 2006 Jan;20(1):112-4 [16293709] Nucleic Acids Res. 2006;34(5):1620-32 [16549874] Nucleic Acids Res. 2002 Feb 1;30(3):782-93 [11809892] Cancer Res. 2002 Mar 1;62(5):1349-55 [11888904] Methods Mol Biol. 2002;197:227-44 [12013799] Am J Physiol Lung Cell Mol Physiol. 2002 Jul;283(1):L205-10 [12060578] J Biol Chem. 2002 Nov 22;277(47):44932-7 [12244119] Oncogene. 2002 Dec 16;21(58):8935-48 [12483510] Cancer Res. 2002 Dec 15;62(24):7230-3 [12499263] Cancer Res. 2004 Sep 1;64(17):6233-9 [15342409] Biochemistry. 2004 Sep 14;43(36):11596-604 [15350146] Nucleic Acids Res. 1988 Feb 11;16(3):1215 [3344216] Proc Natl Acad Sci U S A. 1988 Sep;85(17):6465-7 [3413108] Arch Biochem Biophys. 1991 Mar;285(2):317-24 [1654771] Cancer Res. 1991 Oct 1;51(19):5430-2 [1655250] FEBS Lett. 1992 Sep 7;309(2):193-8 [1324197] FASEB J. 2003 Jul;17(10):1195-214 [12832285] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mutagenesis and modeling of the peroxiredoxin (Prx) complex with the NMR structure of ATP-bound human sulfiredoxin implicate aspartate 187 of Prx I as the catalytic residue in ATP hydrolysis. AN - 68252271; 17176052 AB - The catalytic cysteine of certain members of the peroxiredoxin (Prx) family can be hyperoxidized to cysteinesulfinic acid during reduction of peroxides. Sulfiredoxin is responsible for the ATP-dependent reduction of cysteinesulfinic acid (SO2H) of hyperoxidized Prx. Here we report the NMR solution structure of human sulfiredoxin (hSrx), both with and without bound ATP, and we model the complex of ATP-bound hSrx with Prx. Binding ATP causes only small changes in the NMR structure of hSrx, and the bound ATP conformation is quite similar to that seen for the previously reported X-ray structure of the ADP-hSrx complex. Although hSrx binds ATP, it does not catalyze hydrolysis by itself and has no catalytic acid residue typical of most ATPase and kinase family proteins. For modeling the complex, the ATP-bound hSrx was docked to hyperoxidized Prx II using EMAP of CHARMM. In the model complex, Asn186 of Prx II (Asp187 of Prx I) is in contact with the hSrx-bound ATP beta- and gamma-phosphate groups. Asp187 of Prx I was mutated to alanine and asparagine, and binding and activity of the mutants with hSrx were compared to those of the wild type. For the D187N mutant, both binding and hydrolysis and reduction activities were comparable to those of the wild type, whereas for D187A, binding was unimpaired but ATP hydrolysis and reduction did not occur. The modeling and mutagenesis analyses strongly implicate Asp187 of Prx I as the catalytic residue responsible for ATP hydrolysis in the cysteinesulfinic acid reduction of Prx by hSrx. JF - Biochemistry AU - Lee, Duck-Yeon AU - Park, Sung Jun AU - Jeong, Woojin AU - Sung, Ho Jin AU - Oho, Taena AU - Wu, Xiongwu AU - Rhee, Sue Goo AU - Gruschus, James M AD - Laboratory of Cell Signaling, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-0301, USA. Y1 - 2006/12/26/ PY - 2006 DA - 2006 Dec 26 SP - 15301 EP - 15309 VL - 45 IS - 51 KW - cysteine sulfinic acid KW - 2381-08-0 KW - Aspartic Acid KW - 30KYC7MIAI KW - Asparagine KW - 7006-34-0 KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Oxidoreductases KW - EC 1.- KW - Peroxiredoxins KW - EC 1.11.1.15 KW - Oxidoreductases Acting on Sulfur Group Donors KW - EC 1.8.- KW - SRXN1 protein, human KW - EC 1.8.98.2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Oxidation-Reduction KW - Mutagenesis, Site-Directed KW - Cysteine -- chemistry KW - Humans KW - Asparagine -- genetics KW - Crystallography, X-Ray KW - Protein Structure, Tertiary KW - Hydrolysis KW - Cysteine -- analogs & derivatives KW - Asparagine -- chemistry KW - Magnetic Resonance Spectroscopy KW - Catalysis KW - Aspartic Acid -- genetics KW - Oxidoreductases -- genetics KW - Peroxiredoxins -- chemistry KW - Oxidoreductases -- metabolism KW - Peroxiredoxins -- metabolism KW - Models, Molecular KW - Peroxiredoxins -- genetics KW - Adenosine Triphosphate -- metabolism KW - Oxidoreductases -- chemistry KW - Models, Chemical KW - Aspartic Acid -- chemistry KW - Adenosine Triphosphate -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68252271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Mutagenesis+and+modeling+of+the+peroxiredoxin+%28Prx%29+complex+with+the+NMR+structure+of+ATP-bound+human+sulfiredoxin+implicate+aspartate+187+of+Prx+I+as+the+catalytic+residue+in+ATP+hydrolysis.&rft.au=Lee%2C+Duck-Yeon%3BPark%2C+Sung+Jun%3BJeong%2C+Woojin%3BSung%2C+Ho+Jin%3BOho%2C+Taena%3BWu%2C+Xiongwu%3BRhee%2C+Sue+Goo%3BGruschus%2C+James+M&rft.aulast=Lee&rft.aufirst=Duck-Yeon&rft.date=2006-12-26&rft.volume=45&rft.issue=51&rft.spage=15301&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=1520-4995&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-01-11 N1 - Date created - 2007-03-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 1YZS; PDB; 2B6F N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selection of a novel gp41-specific HIV-1 neutralizing human antibody by competitive antigen panning AN - 19531787; 7245976 AB - The HIV envelope glycoprotein (Env) is composed of two non-covalently associated subunits: gp120 and gp41. Panning of phage-displayed antibody libraries against Env-based antigens has resulted mostly in selection of anti-gp120 antibodies. Native gp41 in the absence of gp120 is unstable. The use of gp41 fragments as antigens has resulted in selection of antibodies with only relatively modest neutralizing activity. To enhance selection of antibodies specific for gp41 in the context of the whole Env we developed a methodology termed competitive antigen panning (CAP). Using CAP, we identified a novel gp41-specific human monoclonal antibody (hmAb), m48, from an immune library derived from long-term nonprogressors with high titers of broadly cross-reactive neutralizing antibodies (bcnAbs). Selection of m48 was only successful using CAP and not through the conventional pre-incubation methodology. In assays based on spreading infection in peripheral blood mononuclear cells (PBMCs) m48 neutralized a panel of HIV-1 primary isolates from different clades more potently than the well-characterized broadly cross-reactive HIV-1-neutralizing antibodies IgG1 4E10 and Fab Z13. These results may have implications for the selection of novel gp41-specific bcnAbs and other antibodies, and for the development of HIV-1 inhibitors and vaccine immunogens. JF - Journal of Immunological Methods AU - Zhang, MY AU - Choudhry, V AU - Sidorov, IA AU - Tenev, V AU - Vu, B K AU - Choudhary, A AU - Lu, H AU - Stiegler, G M AU - Katinger, HWD AU - Jiang, S AU - Broder, C C AU - Dimitrov, D S AD - CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, USA, zhangm@ncifcrf.gov Y1 - 2006/12/20/ PY - 2006 DA - 2006 Dec 20 SP - 21 EP - 30 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 317 IS - 1-2 SN - 0022-1759, 0022-1759 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Spreading KW - Infection KW - Glycoprotein gp120 KW - Peripheral blood mononuclear cells KW - Envelopes KW - Human immunodeficiency virus 1 KW - antibody libraries KW - glycoprotein gp41 KW - Monoclonal antibodies KW - Panning KW - Immunoglobulin G KW - Vaccines KW - Fab KW - F 06900:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19531787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunological+Methods&rft.atitle=Selection+of+a+novel+gp41-specific+HIV-1+neutralizing+human+antibody+by+competitive+antigen+panning&rft.au=Zhang%2C+MY%3BChoudhry%2C+V%3BSidorov%2C+IA%3BTenev%2C+V%3BVu%2C+B+K%3BChoudhary%2C+A%3BLu%2C+H%3BStiegler%2C+G+M%3BKatinger%2C+HWD%3BJiang%2C+S%3BBroder%2C+C+C%3BDimitrov%2C+D+S&rft.aulast=Zhang&rft.aufirst=MY&rft.date=2006-12-20&rft.volume=317&rft.issue=1-2&rft.spage=21&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunological+Methods&rft.issn=00221759&rft_id=info:doi/10.1016%2Fj.jim.2006.09.016 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; glycoprotein gp41; Panning; Glycoprotein gp120; Spreading; Fab; Vaccines; Peripheral blood mononuclear cells; Monoclonal antibodies; antibody libraries; Infection; Immunoglobulin G; Envelopes DO - http://dx.doi.org/10.1016/j.jim.2006.09.016 ER - TY - JOUR T1 - Synergism between CpG-containing oligodeoxynucleotides and IL-2 causes dramatic enhancement of vaccine-elicited CD8+ T cell responses. AN - 68208541; 17142789 AB - Novel anticancer vaccination regimens that can elicit large numbers of Ag-specific T cells are needed. When we administered therapeutic vaccines containing the MHC class I-presented self-peptide tyrosinase-related protein (TRP)-2(180-188) and CpG-containing oligodeoxynucleotides (CpG ODN) to mice, growth of the TRP-2-expressing B16F1 melanoma was not inhibited compared with growth in mice that received control vaccinations. When we added systemic IL-2 to the TRP-2(180-188) plus CpG ODN vaccines, growth of B16F1 was inhibited in a CD8-dependent, epitope-specific manner. Vaccines containing TRP-2(180-188) without CpG ODN did not cause epitope-specific tumor growth inhibition when administered with IL-2. The antitumor efficacy of the different regimens correlated with their ability to elicit TRP-2(180-188)-specific CD8+ T cell responses. When we administered TRP-2(180-188) plus CpG ODN-containing vaccines with systemic IL-2, 18.2% of CD8+ T cells were specific for TRP-2(180-188). Identical TRP-2(180-188) plus CpG ODN vaccines given without IL-2 elicited a TRP-2(180-188)-specific CD8+ T cell response of only 1.1% of CD8+ T cells. Vaccines containing TRP-2(180-188) without CpG ODN elicited TRP-2(180-188)-specific responses of 2.8% of CD8+ T cells when administered with IL-2. There was up to a 221-fold increase in the absolute number of TRP-2(180-188)-specific CD8+ T cells when IL-2 was added to TRP-2(180-188) plus CpG ODN-containing vaccines. Peptide plus CpG ODN vaccines administered with IL-2 generated epitope-specific CD8+ T cells by a mechanism that depended on endogenous IL-6. This is the first report of synergism between CpG ODN and IL-2. This synergism caused a striking increase in vaccine-elicited CD8+ T cells and led to epitope-specific antitumor immunity. JF - Journal of immunology (Baltimore, Md. : 1950) AU - Kochenderfer, James N AU - Chien, Christopher D AU - Simpson, Jessica L AU - Gress, Ronald E AD - Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA. kochendj@mail.nih.gov Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 8860 EP - 8873 VL - 177 IS - 12 SN - 0022-1767, 0022-1767 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - Epitopes, T-Lymphocyte KW - Interleukin-2 KW - Oligodeoxyribonucleotides KW - Intramolecular Oxidoreductases KW - EC 5.3.- KW - dopachrome isomerase KW - EC 5.3.3.12 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - CpG Islands KW - Mice KW - Intramolecular Oxidoreductases -- immunology KW - Immunity -- drug effects KW - Drug Synergism KW - Interleukin-2 -- pharmacology KW - Cancer Vaccines -- immunology KW - CD8-Positive T-Lymphocytes -- drug effects KW - Oligodeoxyribonucleotides -- therapeutic use KW - Cancer Vaccines -- chemistry KW - CD8-Positive T-Lymphocytes -- immunology KW - Interleukin-2 -- therapeutic use KW - Oligodeoxyribonucleotides -- pharmacology KW - Melanoma, Experimental -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68208541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.atitle=Synergism+between+CpG-containing+oligodeoxynucleotides+and+IL-2+causes+dramatic+enhancement+of+vaccine-elicited+CD8%2B+T+cell+responses.&rft.au=Kochenderfer%2C+James+N%3BChien%2C+Christopher+D%3BSimpson%2C+Jessica+L%3BGress%2C+Ronald+E&rft.aulast=Kochenderfer&rft.aufirst=James&rft.date=2006-12-15&rft.volume=177&rft.issue=12&rft.spage=8860&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunology+%28Baltimore%2C+Md.+%3A+1950%29&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Human papillomavirus prevalence in women who have and have not undergone hysterectomies. AN - 68157809; 17109342 AB - We compared human papillomavirus (HPV) prevalence in an age-stratified random sample of women who have undergone a hysterectomy (WH) (n=573) with the HPV prevalence in age-matched women with intact cervices (women who have not undergone a hysterectomy [WNH]) (n=581) participating in a study at Kaiser Permanente in Portland, Oregon. Testing cervicovaginal lavage fluids for >40 HPV genotypes using an MY09/11 L1 consensus primer polymerase chain reaction method, we found no statistical differences in the prevalence of HPV (16% for WNH vs. 13.9% for WH) or carcinogenic HPV (6.5% for WNH vs. 4.5% for WH) between the 2 groups of women. Although WH have a similar prevalence of carcinogenic HPV infection, compared with WNH without a cervix, they have minimal risk of HPV-induced cancer and are unlikely to benefit from HPV testing. JF - The Journal of infectious diseases AU - Castle, Philip E AU - Schiffman, Mark AU - Glass, Andrew G AU - Rush, Brenda B AU - Scott, David R AU - Wacholder, Sholom AU - Dunn, Anne AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD, USA. castlep@mail.nih.gov Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 1702 EP - 1705 VL - 194 IS - 12 SN - 0022-1899, 0022-1899 KW - DNA Primers KW - 0 KW - DNA, Viral KW - Abridged Index Medicus KW - Index Medicus KW - Human papillomavirus 16 -- isolation & purification KW - Humans KW - Vaginal Douching KW - Aged KW - Oregon KW - Polymerase Chain Reaction KW - Adult KW - Middle Aged KW - Human papillomavirus 16 -- genetics KW - DNA, Viral -- genetics KW - Species Specificity KW - Female KW - Papillomaviridae -- classification KW - Hysterectomy KW - Papillomaviridae -- isolation & purification KW - Vagina -- virology KW - Papillomavirus Infections -- virology KW - Uterine Cervical Neoplasms -- surgery KW - Papillomaviridae -- genetics KW - Papillomavirus Infections -- surgery KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68157809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Human+papillomavirus+prevalence+in+women+who+have+and+have+not+undergone+hysterectomies.&rft.au=Castle%2C+Philip+E%3BSchiffman%2C+Mark%3BGlass%2C+Andrew+G%3BRush%2C+Brenda+B%3BScott%2C+David+R%3BWacholder%2C+Sholom%3BDunn%2C+Anne%3BBurk%2C+Robert+D&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2006-12-15&rft.volume=194&rft.issue=12&rft.spage=1702&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-17 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Buprenorphine and HIV primary care: new opportunities for integrated treatment. AN - 68151099; 17109302 AB - Drug abuse and infection with human immunodeficiency virus (HIV) are associated with high rates of morbidity and mortality, but, because of medical, social, and legal factors, opiate addiction/dependence is a major obstacle to successful treatment of disease--for example, treatment of acquired immunodeficiency syndrome (AIDS) with highly active antiretroviral therapy. In an effort to improve the opportunity for treatment of drug abuse and HIV infection, the Forum for Collaborative HIV Research, in collaboration with the Substance Abuse and Mental Health Services Administration, the National Institute on Drug Abuse, the Centers for Disease Control and Prevention, and other agencies, presented a workshop entitled "Buprenorphine in the Primary HIV Care Setting." Participants reviewed and discussed current issues, such as the introduction of and sources for the provision of buprenorphine in HIV primary care settings and strategies for integrating treatment of HIV-infected drug abusers, all of which are covered in this supplement. JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America AU - Khalsa, Jag AU - Vocci, Francis AU - Altice, Frederick AU - Fiellin, David AU - Miller, Veronica AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892-9551, USA. jk98p@nih.gov Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - S169 EP - S172 VL - 43 Suppl 4 KW - Narcotic Antagonists KW - 0 KW - Buprenorphine KW - 40D3SCR4GZ KW - Index Medicus KW - United States KW - Humans KW - Health Services Research KW - Treatment Outcome KW - Incidence KW - Follow-Up Studies KW - Primary Prevention -- methods KW - Antiretroviral Therapy, Highly Active -- methods KW - Male KW - Female KW - Survival Analysis KW - Risk Assessment KW - Opioid-Related Disorders -- mortality KW - Buprenorphine -- therapeutic use KW - Narcotic Antagonists -- therapeutic use KW - HIV Infections -- drug therapy KW - HIV Infections -- mortality KW - Primary Health Care -- methods KW - Opioid-Related Disorders -- drug therapy KW - Delivery of Health Care, Integrated -- methods KW - HIV Infections -- diagnosis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68151099?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.atitle=Buprenorphine+and+HIV+primary+care%3A+new+opportunities+for+integrated+treatment.&rft.au=Khalsa%2C+Jag%3BVocci%2C+Francis%3BAltice%2C+Frederick%3BFiellin%2C+David%3BMiller%2C+Veronica&rft.aulast=Khalsa&rft.aufirst=Jag&rft.date=2006-12-15&rft.volume=43+Suppl+4&rft.issue=&rft.spage=S169&rft.isbn=&rft.btitle=&rft.title=Clinical+infectious+diseases+%3A+an+official+publication+of+the+Infectious+Diseases+Society+of+America&rft.issn=1537-6591&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-13 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 Candidate Vaccine Delivered by a Replication-Defective Recombinant Adenovirus Vector AN - 19522515; 7211371 AB - Background. The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. Here, we report the safety, tolerability, and immunogenicity of a replication-defective recombinant adenovirus serotype 5 (rAd5) vector HIV-1 candidate vaccine. Methods. The vaccine is a mixture of 4 rAd5 vectors that express HIV-1 subtype B Gag-Pol fusion protein and envelope (Env) from subtypes A, B, and C. Healthy, uninfected adults were randomized to receive 1 intramuscular injection of placebo (n = 6) or vaccine at dose levels of 10 super(9) (n = 10), 10 super(10) (n = 10), or 10 super(11) (n = 10) particle units and were followed for 24 weeks to assess immunogenicity and safety. Results. The vaccine was well tolerated but was associated with more reactogenicity at the highest dose. At week 4, vaccine antigen-specific T cell responses were detected in 28 (93.3%) and 18 (60%) of 30 vaccine recipients for CD4 super(+) and CD8 super(+) T cells, respectively, by intracellular cytokine staining assay and in 22 (73%) of 30 vaccine recipients by enzyme-linked immunospot assay. Env-specific antibody responses were detected in 15 (50%) of 30 vaccine recipients by enzyme-linked immunosorbant assay and in 28 (93.3%) of 30 vaccine recipients by immunoprecipitation followed by Western blotting. No neutralizing antibody was detected. Conclusions. A single injection induced HIV-1 antigen-specific CD4 T cell, CD8 super(+) T cell, and antibody responses in the majority of vaccine recipients. This multiclade rAd5 HIV-1 vaccine is now being evaluated in combination with a multiclade HIV-1 DNA plasmid vaccine. JF - Journal of Infectious Diseases AU - Catanzaro, A T AU - Koup, R A AU - Roederer, M AU - Bailer, R T AU - Enama, ME AU - Moodie, Z AU - Gu, L AU - Martin, JE AU - Novik, L AU - Chakrabarti, B K AU - Butman, B T AU - Gall, JGD AU - King, C R AU - Andrews, CA AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 1638 EP - 1649 VL - 194 IS - 12 SN - 0022-1899, 0022-1899 KW - Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts KW - Western blotting KW - vaccines KW - Enzyme-linked immunosorbent assay KW - Serotypes KW - Adenovirus KW - Immunoprecipitation KW - CD8 antigen KW - Plasmids KW - Expression vectors KW - CD4 antigen KW - Antibodies KW - Envelopes KW - DNA vaccines KW - Immunogenicity KW - Human immunodeficiency virus 1 KW - DNA KW - Lymphocytes T KW - Proteins KW - Cytokines KW - Fusion protein KW - Vaccines KW - Side effects KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522515?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Phase+1+Safety+and+Immunogenicity+Evaluation+of+a+Multiclade+HIV-1+Candidate+Vaccine+Delivered+by+a+Replication-Defective+Recombinant+Adenovirus+Vector&rft.au=Catanzaro%2C+A+T%3BKoup%2C+R+A%3BRoederer%2C+M%3BBailer%2C+R+T%3BEnama%2C+ME%3BMoodie%2C+Z%3BGu%2C+L%3BMartin%2C+JE%3BNovik%2C+L%3BChakrabarti%2C+B+K%3BButman%2C+B+T%3BGall%2C+JGD%3BKing%2C+C+R%3BAndrews%2C+CA&rft.aulast=Catanzaro&rft.aufirst=A&rft.date=2006-12-15&rft.volume=194&rft.issue=12&rft.spage=1638&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Western blotting; Enzyme-linked immunosorbent assay; Serotypes; Immunoprecipitation; CD8 antigen; Plasmids; Expression vectors; Antibodies; CD4 antigen; Envelopes; DNA vaccines; Immunogenicity; Lymphocytes T; Cytokines; Vaccines; Fusion protein; vaccines; DNA; Proteins; Side effects; Human immunodeficiency virus 1; Adenovirus ER - TY - JOUR T1 - Escherichia coli BL21(DE3) chromosome contains a group II capsular gene cluster AN - 19520002; 7203397 AB - During our study of de novo synthesis of Escherichia coli K1 capsular polysaccharides, we found that E. coli BL21(DE3) has a capsular gene cluster, similar to those of group II capsular E. coli strains. Analysis of the nucleotide sequence of the E. coli BL21(DE3) gene cluster showed homologues to all group II regions 1 and 3 genes and the presence of an IS1 element in one of the region 2 ORFs, which likely prevents capsule expression. Complementation analysis showed that region 1 and 3 genes encode functional proteins that are sufficient for the export of newly synthesized polysaccharide. The gene products of Bl21(DE3) kpsC and kpsS supported in vitro de novo synthesis of K1 polysaccharide when co-expressed with K1 NeuE and NeuS. Sequence homology between BL21(DE3) region 2 open reading frames and capsule-related genes in other bacteria such as Haemophilus influenzae serotype b, suggests that the encapsulated ancestor of BL21(DE3) may have produced a ribose/ribitol-phosphate containing polysaccharide. JF - Gene AU - Andreishcheva, EN AU - Vann, W F AD - Center for Biologics Evaluation and Research, Building 29, Room 103, 8800 Rockville Pike, Bethesda, MD 20892, USA, wvann@helix.nih.gov Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 113 EP - 119 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 384 SN - 0378-1119, 0378-1119 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Haemophilus influenzae KW - Serotypes KW - Nucleotide sequence KW - Ribose KW - Polysaccharides KW - Chromosomes KW - Complementation KW - Homology KW - Neu protein KW - Gene clusters KW - Escherichia coli KW - Open reading frames KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19520002?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Escherichia+coli+BL21%28DE3%29+chromosome+contains+a+group+II+capsular+gene+cluster&rft.au=Andreishcheva%2C+EN%3BVann%2C+W+F&rft.aulast=Andreishcheva&rft.aufirst=EN&rft.date=2006-12-15&rft.volume=384&rft.issue=&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2006.07.020 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chromosomes; Complementation; Serotypes; Homology; Nucleotide sequence; Neu protein; Ribose; Gene clusters; Polysaccharides; Open reading frames; Haemophilus influenzae; Escherichia coli DO - http://dx.doi.org/10.1016/j.gene.2006.07.020 ER - TY - JOUR T1 - Human Cytolytic T Cell Recognition of Yersinia pestis Virulence Proteins That Target Innate Immune Responses AN - 19519291; 7211385 AB - Cell contact by the plague bacterium Yersinia pestis initiates the injection of several virulence factors that target biochemical pathways critical for host clearance of bacteria. Despite this impairment of innate immunity, it is unclear whether antigen recognition by T cells is equally affected. We present evidence that human cytolytic T cells respond to Y. pestis virulence proteins presented by infected monocytes and dendritic cells. These T cell antigens consisted of a panel of proteins encoded by pCD1, a 70-kDa plasmid that harbors virulence factors and transport proteins of the cell contact-dependent, type III secretion system. Infected cells retained the ability to process and present tetanus toxoid to T cells, which indicates that responses to unrelated antigens were also maintained. Our results indicate that T cell immunity remains functional during Y. pestis infection, which thus suggests the potential benefits of therapeutic vaccination and strategies that emphasize the inclusion of cytotoxic T lymphocyte responses. JF - Journal of Infectious Diseases AU - Saikh, K U AU - Kissner, T L AU - Dyas, B AU - Tropea, JE AU - Waugh, D S AU - Ulrich, R G AD - Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, and Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland, USA Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 1753 EP - 1760 VL - 194 IS - 12 SN - 0022-1899, 0022-1899 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - virulence factors KW - Yersinia pestis KW - Toxoids KW - Plasmids KW - Tetanus KW - Infection KW - Vaccination KW - Virulence KW - Dendritic cells KW - Cytotoxicity KW - Lymphocytes T KW - Monocytes KW - Plague KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19519291?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Human+Cytolytic+T+Cell+Recognition+of+Yersinia+pestis+Virulence+Proteins+That+Target+Innate+Immune+Responses&rft.au=Saikh%2C+K+U%3BKissner%2C+T+L%3BDyas%2C+B%3BTropea%2C+JE%3BWaugh%2C+D+S%3BUlrich%2C+R+G&rft.aulast=Saikh&rft.aufirst=K&rft.date=2006-12-15&rft.volume=194&rft.issue=12&rft.spage=1753&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Virulence; Dendritic cells; Cytotoxicity; virulence factors; Lymphocytes T; Toxoids; Plague; Monocytes; Infection; Tetanus; Plasmids; Vaccination; Yersinia pestis ER - TY - JOUR T1 - Phase 1 Safety and Immunogenicity Evaluation of a Multiclade HIV-1 DNA Candidate Vaccine AN - 19515759; 7211372 AB - Background. Gene-based vaccine delivery is an important strategy in the development of a preventive vaccine for acquired immunodeficiency syndrome (AIDS). Vaccine Research Center (VRC) 004 is the first phase 1 dose-escalation study of a multiclade HIV-1 DNA vaccine. Methods. VRC-HIVDNA009-00-VP is a 4-plasmid mixture encoding subtype B Gag-Pol-Nef fusion protein and modified envelope (Env) constructs from subtypes A, B, and C. Fifty healthy, uninfected adults were randomized to receive either placebo (n = 10) or study vaccine at 2 mg (n = 5), 4 mg (n = 20), or 8 mg (n = 15) by needle-free intramuscular injection. Humoral responses (measured by enzyme-linked immunosorbant assay, Western blotting, and neutralization assay) and T cell responses (measured by enzyme-linked immunospot assay and intracellular cytokine staining after stimulation with antigen-specific peptide pools) were measured. Results. The vaccine was well tolerated and induced cellular and humoral responses. The maximal CD4 super(+) and CD8 super(+) T cell responses occurred after 3 injections and were in response to Env peptide pools. The pattern of cytokine expression by vaccine-induced HIV-specific T cells evolved over time, with a diminished frequency of interferon- gamma -producing T cells and an increased frequency of interleukin-2-producing T cells at 1 year. Conclusions. DNA vaccination induced antibody to and T cell responses against 3 major HIV-1 subtypes and will be further evaluated as a potential component of a preventive AIDS vaccine regimen. JF - Journal of Infectious Diseases AU - Graham, B S AU - Koup, R A AU - Roederer, M AU - Bailer, R T AU - Enama, ME AU - Moodie, Z AU - Martin, JE AU - McCluskey, M M AU - Chakrabarti, B K AU - Lamoreaux, L AU - Andrews, CA AU - Gomez, P L AU - Mascola, J R AU - Nabel, G J AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/12/15/ PY - 2006 DA - 2006 Dec 15 SP - 1650 EP - 1660 VL - 194 IS - 12 SN - 0022-1899, 0022-1899 KW - HIV-1 KW - Biochemistry Abstracts 2: Nucleic Acids; Health & Safety Science Abstracts; Virology & AIDS Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Western blotting KW - vaccines KW - Enzyme-linked immunosorbent assay KW - Acquired immune deficiency syndrome KW - Immunodeficiency KW - CD8 antigen KW - Vaccination KW - CD4 antigen KW - Antibodies KW - Envelopes KW - DNA vaccines KW - Immunogenicity KW - Human immunodeficiency virus 1 KW - DNA KW - Lymphocytes T KW - Proteins KW - Cytokines KW - Fusion protein KW - Vaccines KW - Neutralization KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines KW - N 14810:Methods KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515759?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Infectious+Diseases&rft.atitle=Phase+1+Safety+and+Immunogenicity+Evaluation+of+a+Multiclade+HIV-1+DNA+Candidate+Vaccine&rft.au=Graham%2C+B+S%3BKoup%2C+R+A%3BRoederer%2C+M%3BBailer%2C+R+T%3BEnama%2C+ME%3BMoodie%2C+Z%3BMartin%2C+JE%3BMcCluskey%2C+M+M%3BChakrabarti%2C+B+K%3BLamoreaux%2C+L%3BAndrews%2C+CA%3BGomez%2C+P+L%3BMascola%2C+J+R%3BNabel%2C+G+J&rft.aulast=Graham&rft.aufirst=B&rft.date=2006-12-15&rft.volume=194&rft.issue=12&rft.spage=1650&rft.isbn=&rft.btitle=&rft.title=Journal+of+Infectious+Diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Western blotting; Acquired immune deficiency syndrome; Enzyme-linked immunosorbent assay; Immunodeficiency; CD8 antigen; Vaccination; Antibodies; CD4 antigen; Envelopes; DNA vaccines; Immunogenicity; Lymphocytes T; Cytokines; Vaccines; Fusion protein; vaccines; DNA; Proteins; Neutralization; Human immunodeficiency virus 1 ER - TY - CPAPER T1 - HER-2 Overexpression Promotes the Brain Metastasis of Breast Cancer. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40486489; 4481109 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Steeg, P S AU - Palmieri, D AU - Bronder, J L AU - Herring, J L AU - Halverson, D AU - Vega-Valle, E AU - Feigenbaum, L AU - Yoneda, T AU - Weil, R J AU - Stark, A M AU - Vortmeyer, A O AU - Kurek, R AU - Aldape, K Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Brain KW - Breast cancer KW - ErbB-2 protein KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40486489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=HER-2+Overexpression+Promotes+the+Brain+Metastasis+of+Breast+Cancer.&rft.au=Steeg%2C+P+S%3BPalmieri%2C+D%3BBronder%2C+J+L%3BHerring%2C+J+L%3BHalverson%2C+D%3BVega-Valle%2C+E%3BFeigenbaum%2C+L%3BYoneda%2C+T%3BWeil%2C+R+J%3BStark%2C+A+M%3BVortmeyer%2C+A+O%3BKurek%2C+R%3BAldape%2C+K&rft.aulast=Steeg&rft.aufirst=P&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risk Factor- and Age-Specific Interactions Suggest different Etiologies for Early-Onset and Late-Onset Types of Breast Cancer T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40485369; 4481175 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Anderson, W F AU - Matsuno, R K AU - Yang, X AU - Sherman, M E AU - Garcia-Closas, M Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Etiology KW - Breast cancer KW - Age KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40485369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Risk+Factor-+and+Age-Specific+Interactions+Suggest+different+Etiologies+for+Early-Onset+and+Late-Onset+Types+of+Breast+Cancer&rft.au=Anderson%2C+W+F%3BMatsuno%2C+R+K%3BYang%2C+X%3BSherman%2C+M+E%3BGarcia-Closas%2C+M&rft.aulast=Anderson&rft.aufirst=W&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Influence of Antibiotic Treatment on Breast Carcinoma Development and Mammary Gland Morphogenesis in Murine Models. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40483104; 4481169 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Rossini, A AU - Rumio, C AU - Sfondrini, L AU - Tagliabue, E AU - Morelli, D AU - Miceli, R AU - Mariani, L AU - Palazzo, M AU - Menard, S AU - Balsari, A Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Antibiotics KW - Mammary gland KW - Animal models KW - Breast carcinoma KW - Morphogenesis KW - Tumors KW - Glands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40483104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Influence+of+Antibiotic+Treatment+on+Breast+Carcinoma+Development+and+Mammary+Gland+Morphogenesis+in+Murine+Models.&rft.au=Rossini%2C+A%3BRumio%2C+C%3BSfondrini%2C+L%3BTagliabue%2C+E%3BMorelli%2C+D%3BMiceli%2C+R%3BMariani%2C+L%3BPalazzo%2C+M%3BMenard%2C+S%3BBalsari%2C+A&rft.aulast=Rossini&rft.aufirst=A&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microarray Analysis of Resected Brain Metastases of Breast Cancer. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40482550; 4481110 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Steeg, P S AU - Palmieri, D AU - Bronder, J L AU - Halverson, D AU - Yoneda, T AU - Weil, R J AU - Stark, A M AU - Vortmeyer, A O AU - Kurek, R AU - Davis, S AU - Meltzer, P S Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Brain KW - Breast cancer KW - Metastases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40482550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Microarray+Analysis+of+Resected+Brain+Metastases+of+Breast+Cancer.&rft.au=Steeg%2C+P+S%3BPalmieri%2C+D%3BBronder%2C+J+L%3BHalverson%2C+D%3BYoneda%2C+T%3BWeil%2C+R+J%3BStark%2C+A+M%3BVortmeyer%2C+A+O%3BKurek%2C+R%3BDavis%2C+S%3BMeltzer%2C+P+S&rft.aulast=Steeg&rft.aufirst=P&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling to Predict Response to Neoadjuvant Docetaxel and Capecitabine for Breast Cancer. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40468191; 4480902 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Korde, L AU - Zujewski, J AU - McShane, L AU - Lukes, L AU - Lebowitz, P AU - Finney, R AU - Hunter, K Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Breast cancer KW - Gene expression KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40468191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Gene+Expression+Profiling+to+Predict+Response+to+Neoadjuvant+Docetaxel+and+Capecitabine+for+Breast+Cancer.&rft.au=Korde%2C+L%3BZujewski%2C+J%3BMcShane%2C+L%3BLukes%2C+L%3BLebowitz%2C+P%3BFinney%2C+R%3BHunter%2C+K&rft.aulast=Korde&rft.aufirst=L&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preliminary Evaluation of p53 Mutation Type, Tumor Characteristics and Clinical Response among Neoadjuvantly Treated Breast Cancer Patients in I-SPY1 (CALGB 150007/ACRIN 6657). T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40468161; 4480891 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Conway, K AU - Edmiston, S N AU - Tolbert, D AU - Moore, D Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Mutation KW - Breast cancer KW - P53 protein KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40468161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Preliminary+Evaluation+of+p53+Mutation+Type%2C+Tumor+Characteristics+and+Clinical+Response+among+Neoadjuvantly+Treated+Breast+Cancer+Patients+in+I-SPY1+%28CALGB+150007%2FACRIN+6657%29.&rft.au=Conway%2C+K%3BEdmiston%2C+S+N%3BTolbert%2C+D%3BMoore%2C+D&rft.aulast=Conway&rft.aufirst=K&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Are we Closer to Preventing Breast Cancer? Progress in Phase III Clinical Trials T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40466351; 4481477 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Ford, Leslie G Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Clinical trials KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40466351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Are+we+Closer+to+Preventing+Breast+Cancer%3F+Progress+in+Phase+III+Clinical+Trials&rft.au=Ford%2C+Leslie+G&rft.aulast=Ford&rft.aufirst=Leslie&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluation of E-Cadherin Expression and Lymphatic Involvement in Inflammatory Breast Cancer. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40465162; 4481022 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Portera, C C AU - Yang, S X AU - Wedam, S B AU - Nguyen, D AU - Vatas, U AU - Takikita, M AU - Hewitt, S M AU - Liewehr, D J AU - Steinberg, S M AU - Sherman, M AU - Levine, P H AU - Swain, S M Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Breast cancer KW - Inflammation KW - E-Cadherin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40465162?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Evaluation+of+E-Cadherin+Expression+and+Lymphatic+Involvement+in+Inflammatory+Breast+Cancer.&rft.au=Portera%2C+C+C%3BYang%2C+S+X%3BWedam%2C+S+B%3BNguyen%2C+D%3BVatas%2C+U%3BTakikita%2C+M%3BHewitt%2C+S+M%3BLiewehr%2C+D+J%3BSteinberg%2C+S+M%3BSherman%2C+M%3BLevine%2C+P+H%3BSwain%2C+S+M&rft.aulast=Portera&rft.aufirst=C&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Sharp Decrease in Breast Cancer Incidence in the United States in 2003. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40464578; 4481435 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Ravdin, P M AU - Cronin, K A AU - Howlander, N AU - Chlebowski, R T AU - Berry, D A Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - USA KW - Breast cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40464578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=A+Sharp+Decrease+in+Breast+Cancer+Incidence+in+the+United+States+in+2003.&rft.au=Ravdin%2C+P+M%3BCronin%2C+K+A%3BHowlander%2C+N%3BChlebowski%2C+R+T%3BBerry%2C+D+A&rft.aulast=Ravdin&rft.aufirst=P&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Dimethylbenzanthracene (DMBA) to Facilitate Carcinogenesis in Virgin Female FVB Mice Expressing MMTV-Neu or MMTV-Neu/p53 knock-Out. T2 - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AN - 40463068; 4480671 JF - 29th Annual San Antonio Breast Cancer Symposium (SABCS 2006) AU - Lubet, R A AU - Ruppert, M J AU - Juliana, M M AU - Lobo-Ruppert, S M AU - Grubbs, C J Y1 - 2006/12/14/ PY - 2006 DA - 2006 Dec 14 KW - Mice KW - Carcinogenesis KW - P53 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40463068?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.atitle=Use+of+Dimethylbenzanthracene+%28DMBA%29+to+Facilitate+Carcinogenesis+in+Virgin+Female+FVB+Mice+Expressing+MMTV-Neu+or+MMTV-Neu%2Fp53+knock-Out.&rft.au=Lubet%2C+R+A%3BRuppert%2C+M+J%3BJuliana%2C+M+M%3BLobo-Ruppert%2C+S+M%3BGrubbs%2C+C+J&rft.aulast=Lubet&rft.aufirst=R&rft.date=2006-12-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=29th+Annual+San+Antonio+Breast+Cancer+Symposium+%28SABCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.sabcs.org/ProgramSchedule/ScheduleGlance.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Integrating Transcriptome and Proteome Profiling at the Sympathoadrenal Synapse: Non-Linear Pathways for Intracellular Signaling in Neuroendocrine Cells. T2 - 2006 Mediterranean Conference of Neurosciences AN - 39337967; 4530559 JF - 2006 Mediterranean Conference of Neurosciences AU - Eiden, Lee E Y1 - 2006/12/13/ PY - 2006 DA - 2006 Dec 13 KW - Adrenal glands KW - Sympathetic nervous system KW - Intracellular signalling KW - Synapses KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39337967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Mediterranean+Conference+of+Neurosciences&rft.atitle=Integrating+Transcriptome+and+Proteome+Profiling+at+the+Sympathoadrenal+Synapse%3A+Non-Linear+Pathways+for+Intracellular+Signaling+in+Neuroendocrine+Cells.&rft.au=Eiden%2C+Lee+E&rft.aulast=Eiden&rft.aufirst=Lee&rft.date=2006-12-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Mediterranean+Conference+of+Neurosciences&rft.issn=&rft_id=info:doi/ L2 - http://www.ucam.ac.ma/neurosci.med2006/index_Eng.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Renal atrial natriuretic peptide receptors binding properties and function are resistant to DOCA-salt-induced hypertension in rats. AN - 68238702; 16904201 AB - Atrial natriuretic peptide receptor types A (NPR-A) and C (NPR-C) binding properties and functional characteristics in renal glomeruli have been investigated in deoxycorticosterone acetate (DOCA)-treated hypertensive Wistar-Kyoto (WKY) rats and their respective controls. We found that DOCA administration had no significant effect on the maximum binding capacity or the affinity of renal NPR-A and NPR-C. NPR-C is involved in the regulation of cAMP production. Our results indicate that the cAMP production by NPR-C is not altered in DOCA-induced hypertension, since ANP(1-28), CNP(1-22) and C-ANP, which specifically bind to NPR-C, show a similar inhibitory effect on cAMP production stimulated by the physiological agonist histamine in glomeruli from DOCA-treated rats and controls. Finally, we have found that DOCA-induced hypertension does not modify NPR-A or NPR-C expression in rat glomerular membranes. These findings indicate that NPR-A and NPR-C binding properties and NPR-C-mediated inhibition of cAMP generation remain unaltered in DOCA-treated rats. JF - Regulatory peptides AU - Li, Xiaohong AU - Woodard, Geoffrey E AU - Brown, John AU - Rosado, Juan A AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, Rm 8C-208, 10 Center Drive, MSC 1752, Bethesda, MD 20892-1752, USA. GeoffreyW@intra.niddk.nih.gov Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 SP - 114 EP - 120 VL - 137 IS - 3 SN - 0167-0115, 0167-0115 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - Atrial Natriuretic Factor KW - 85637-73-6 KW - Cyclic AMP KW - E0399OZS9N KW - Guanylate Cyclase KW - EC 4.6.1.2 KW - Receptors, Atrial Natriuretic Factor KW - atrial natriuretic factor receptor A KW - atrial natriuretic factor receptor C KW - Index Medicus KW - Rats KW - Guanylate Cyclase -- metabolism KW - Animals KW - Desoxycorticosterone -- toxicity KW - Rats, Inbred WKY KW - Binding, Competitive KW - Cyclic AMP -- metabolism KW - Atrial Natriuretic Factor -- metabolism KW - Kidney Glomerulus -- metabolism KW - Male KW - Kidney -- metabolism KW - Hypertension -- chemically induced KW - Receptors, Atrial Natriuretic Factor -- metabolism KW - Hypertension -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68238702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Regulatory+peptides&rft.atitle=Renal+atrial+natriuretic+peptide+receptors+binding+properties+and+function+are+resistant+to+DOCA-salt-induced+hypertension+in+rats.&rft.au=Li%2C+Xiaohong%3BWoodard%2C+Geoffrey+E%3BBrown%2C+John%3BRosado%2C+Juan+A&rft.aulast=Li&rft.aufirst=Xiaohong&rft.date=2006-12-10&rft.volume=137&rft.issue=3&rft.spage=114&rft.isbn=&rft.btitle=&rft.title=Regulatory+peptides&rft.issn=01670115&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-07 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Regul Pept. 2008 Apr 10;147(1-3):111 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - P-selectin activates integrin-mediated colon carcinoma cell adhesion to fibronectin. AN - 68214146; 17056038 AB - During hematogenous cancer metastasis, tumor cells separate from a primary mass, enter the bloodstream, disperse throughout the body, migrate across vessel walls, and generate distant colonies. The later steps of metastasis superficially resemble leukocyte extravasation, a process initiated by selectin-mediated cell tethering to the blood vessel wall followed by integrin-mediated arrest and transendothelial migration. Some cancer cells express P-selectin ligands and attach to immobilized P-selectin, suggesting that these cells can arrest in blood vessels using sequential selectin- and integrin-mediated adhesion, as do leukocytes. We hypothesize that selectin binding may regulate subsequent integrin-mediated steps in metastasis. Using a model system of cultured Colo 320 human colon adenocarcinoma cells incubated with soluble P-selectin-IgG chimeric protein, we have found that P-selectin can stimulate activation of the alpha(5)beta(1) integrin resulting in a specific increase of adhesion and spreading of these cells on fibronectin substrates. P-selectin binding also induced activation of p38 mitogen-activated protein kinase (p38 MAPK) and phosphatidylinositol 3-kinase (PI3-K). PI3-K inhibitors blocked P-selectin-mediated integrin activation, cell attachment, and cell spreading. Inhibition of p38 MAPK activation blocked cell spreading, but not cell attachment. P-selectin binding also resulted in formation of a signaling complex containing PI3-K and p38 MAPK. These results suggest that P-selectin binding to tumor cells can activate alpha(5)beta(1) integrin via PI3-K and p38 MAPK signaling pathways leading to increased cell adhesion. We propose that P-selectin ligands are important tumor cell signaling molecules that modulate integrin-mediated cell adhesion in the metastatic process. JF - Experimental cell research AU - Reyes-Reyes, Merit E AU - George, Margaret D AU - Roberts, John D AU - Akiyama, Steven K AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA. Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 SP - 4056 EP - 4069 VL - 312 IS - 20 SN - 0014-4827, 0014-4827 KW - Fibronectins KW - 0 KW - Integrin alpha5beta1 KW - P-Selectin KW - Phosphatidylinositol 3-Kinases KW - EC 2.7.1.- KW - p38 Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Index Medicus KW - MAP Kinase Signaling System KW - Phosphatidylinositol 3-Kinases -- metabolism KW - Enzyme Activation KW - Humans KW - Cell Line, Tumor KW - Protein Binding KW - p38 Mitogen-Activated Protein Kinases -- metabolism KW - Cell Adhesion KW - Adenocarcinoma -- metabolism KW - Integrin alpha5beta1 -- physiology KW - Integrin alpha5beta1 -- metabolism KW - Fibronectins -- metabolism KW - P-Selectin -- pharmacology KW - Colonic Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68214146?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=P-selectin+activates+integrin-mediated+colon+carcinoma+cell+adhesion+to+fibronectin.&rft.au=Reyes-Reyes%2C+Merit+E%3BGeorge%2C+Margaret+D%3BRoberts%2C+John+D%3BAkiyama%2C+Steven+K&rft.aulast=Reyes-Reyes&rft.aufirst=Merit&rft.date=2006-12-10&rft.volume=312&rft.issue=20&rft.spage=4056&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-13 N1 - Date created - 2006-12-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2004 Jan 15;10(2):701-7 [14760093] Cancer Res. 2004 Apr 15;64(8):2743-50 [15087389] J Biol Chem. 2004 Apr 23;279(17):17897-904 [14973141] Crit Rev Oncol Hematol. 2004 May;50(2):87-100 [15157658] Mol Cells. 2004 Apr 30;17(2):188-202 [15179030] Biochem Biophys Res Commun. 2004 Jul 30;320(3):773-80 [15240115] Pancreas. 2005 Oct;31(3):263-74 [16163059] Cell Cycle. 2005 Sep;4(9):1189-92 [16103752] Curr Top Med Chem. 2005;5(10):921-8 [16178737] Breast Cancer Res Treat. 2005 Sep;93(2):159-68 [16187236] Int J Cancer. 2006 Jul 1;119(1):8-16 [16450376] Clin Exp Metastasis. 1999 Jul;17(5):377-87 [10651304] Mol Cell Biol. 2000 Mar;20(6):1956-69 [10688643] J Biol Chem. 2000 Apr 14;275(15):11284-90 [10753939] J Immunol. 2000 Apr 15;164(8):4348-58 [10754335] FASEB J. 2000 Aug;14(11):1629-40 [10928998] Exp Cell Res. 2001 Feb 1;263(1):65-76 [11161706] Nat Immunol. 2001 Jan;2(1):29-36 [11135575] J Cell Sci. 2001 Apr;114(Pt 8):1579-89 [11282033] FEBS Lett. 2001 Jun 15;499(1-2):176-81 [11418135] APMIS. 2001 Apr;109(4):241-62 [11469496] Thromb Haemost. 2001 Jul;86(1):316-23 [11487020] J Biol Chem. 2001 Sep 7;276(36):33762-72 [11448946] Cell Tissue Res. 2001 Sep;305(3):285-98 [11572082] J Cell Physiol. 2001 Oct;189(1):1-13 [11573199] EMBO J. 2001 Nov 15;20(22):6327-36 [11707404] Oncogene. 2001 Dec 6;20(56):8066-74 [11781819] Mol Endocrinol. 2002 Mar;16(3):552-62 [11875115] J Clin Invest. 2002 Apr;109(7):863-7 [11927612] Nat Cell Biol. 2002 Apr;4(4):E65-8 [11944032] J Cell Biol. 2002 Sep 2;158(5):833-9 [12213832] Cell. 2002 Sep 20;110(6):673-87 [12297042] Bioessays. 2002 Oct;24(10):885-93 [12325121] Nat Rev Cancer. 2002 Feb;2(2):91-100 [12635172] J Biol Chem. 2003 Mar 21;278(12):10556-61 [12522146] J Clin Invest. 2003 Mar;111(6):833-41 [12639989] Dev Cell. 2003 Aug;5(2):257-71 [12919677] Circ Res. 2003 Nov 28;93(11):1026-8 [14593000] Biophys J. 2004 Jan;86(1 Pt 1):544-54 [14695299] Gut. 1992 Mar;33(3):342-6 [1568652] Cancer Metastasis Rev. 1992 Nov;11(3-4):227-35 [1423815] Cell. 1996 Aug 23;86(4):643-53 [8752218] Am J Pathol. 1996 Nov;149(5):1661-73 [8909255] Cell Growth Differ. 1997 Jan;8(1):83-90 [8993837] Int J Cancer. 1997 Jan 17;70(2):201-7 [9009161] J Immunol. 1997 Feb 1;158(3):1061-7 [9013943] Surgery. 2004 Aug;136(2):143-9 [15300173] J Biol Chem. 2004 Sep 24;279(39):40807-18 [15272025] Ann N Y Acad Sci. 1981;370:101-18 [6943955] Thromb Res. 1982 Jul 1;27(1):1-14 [6812233] J Biol Chem. 1985 Apr 10;260(7):4492-500 [3920218] J Cell Biol. 1986 Feb;102(2):442-8 [2935540] J Cell Biol. 1989 Aug;109(2):863-75 [2527241] Nature. 1989 Dec 14;342(6251):811-3 [2574829] J Pathol. 1990 Jan;160(1):35-40 [2179505] Science. 1990 Nov 23;250(4984):1132-5 [1701275] Am J Pathol. 1991 Mar;138(3):741-50 [2000944] J Biol Chem. 1991 Apr 25;266(12):7345-52 [1902217] J Exp Med. 1991 Jun 1;173(6):1493-500 [1709677] Lab Invest. 1992 Mar;66(3):324-30 [1371572] Biochem Biophys Res Commun. 1992 Feb 14;182(3):1376-82 [1371681] Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2292-6 [1372439] Eur J Immunol. 1998 Feb;28(2):433-43 [9521050] Br J Cancer. 1998 Jun;77(12):2069-75 [9649116] J Immunol. 1998 Jul 15;161(2):836-42 [9670961] Biochemistry. 1998 Jul 21;37(29):10514-21 [9671523] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9325-30 [9689079] FASEB J. 1998 Sep;12(12):1241-51 [9737727] Biochim Biophys Acta. 1998 Dec 8;1436(1-2):127-50 [9838078] Physiol Rev. 1999 Jan;79(1):181-213 [9922371] J Immunol. 1999 Mar 1;162(5):2850-7 [10072533] Science. 1999 Aug 13;285(5430):1028-32 [10446041] J Clin Invest. 2005 Feb;115(2):339-47 [15668738] Curr Opin Cell Biol. 2005 Apr;17(2):141-9 [15780590] Oncogene. 2005 Mar 24;24(13):2218-28 [15688026] Cancer Res. 1993 Jan 15;53(2):354-61 [7678075] Eur J Surg Oncol. 1993 Feb;19(1):50-60 [8436241] J Cell Biol. 1993 Apr;121(2):449-59 [7682218] Int J Cancer. 1993 Jul 30;54(6):972-7 [7687590] J Clin Invest. 1993 Aug;92(2):804-13 [7688763] J Biol Chem. 1993 Oct 15;268(29):21459-62 [7691809] Semin Cancer Biol. 1993 Oct;4(5):319-24 [7903054] Cell. 1993 Dec 17;75(6):1179-86 [7505206] J Biol Chem. 1994 Jan 14;269(2):1425-31 [7507108] Cell. 1994 Jan 28;76(2):301-14 [7507411] Anticancer Res. 1993 Nov-Dec;13(6A):2229-37 [8297138] J Cell Biol. 1994 Sep;126(5):1287-98 [8063864] J Immunol. 1994 Oct 1;153(7):3199-209 [7522253] Proc Natl Acad Sci U S A. 1994 Sep 13;91(19):8767-71 [7522321] Clin Exp Metastasis. 1994 Nov;12(6):357-67 [7923988] Int Immunol. 1994 Jul;6(7):1027-36 [7524641] J Biol Chem. 1994 Nov 4;269(44):27224-30 [7525548] Int J Cancer. 1995 Jan 27;60(3):426-31 [7530236] Eur J Cancer. 1994;30A(14):2166-70 [7857718] EMBO J. 1995 Feb 1;14(3):473-83 [7532131] J Immunol. 1995 Mar 1;154(5):2291-302 [7532664] Nat Struct Biol. 1994 Dec;1(12):898-907 [7773779] J Immunol. 1995 Aug 1;155(3):1502-14 [7543524] Exp Cell Res. 1995 Aug;219(2):571-8 [7641809] Blood. 1995 Sep 15;86(6):2086-90 [7545020] Cancer Res. 1995 Oct 1;55(19):4425-31 [7545541] Cancer Surv. 1995;24:67-79 [7553663] Br J Cancer. 1996 Apr;73(7):887-92 [8611401] J Biol Chem. 1996 May 10;271(19):11067-75 [8626649] Blood. 1997 May 1;89(9):3385-95 [9129046] Int J Cancer. 1997 May 16;71(4):645-53 [9178821] J Biol Chem. 1998 Jan 9;273(2):763-70 [9422729] J Biol Chem. 1998 Jan 9;273(2):940-4 [9422753] Trends Biochem Sci. 1998 Jan;23(1):30-4 [9478133] Cancer Res. 1998 Feb 15;58(4):848-53 [9485045] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Cancer Biomedical Informatics Grid (caBIG): Enabling Patient-Centric Molecular Medicine T2 - 17th IBC Antibody Engineering Conference AN - 39345167; 4508430 JF - 17th IBC Antibody Engineering Conference AU - Buetow, Kenneth H Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Cancer KW - Informatics KW - Bioinformatics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+IBC+Antibody+Engineering+Conference&rft.atitle=The+Cancer+Biomedical+Informatics+Grid+%28caBIG%29%3A+Enabling+Patient-Centric+Molecular+Medicine&rft.au=Buetow%2C+Kenneth+H&rft.aulast=Buetow&rft.aufirst=Kenneth&rft.date=2006-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+IBC+Antibody+Engineering+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng/2740.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The NIAID Program for the Development of Antibody-Based Treatments for Biodefense and Emerging Infectious Diseases T2 - 17th IBC Antibody Engineering Conference AN - 39345112; 4508420 JF - 17th IBC Antibody Engineering Conference AU - Taylor, Katherine A Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Infectious diseases KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39345112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=17th+IBC+Antibody+Engineering+Conference&rft.atitle=The+NIAID+Program+for+the+Development+of+Antibody-Based+Treatments+for+Biodefense+and+Emerging+Infectious+Diseases&rft.au=Taylor%2C+Katherine+A&rft.aulast=Taylor&rft.aufirst=Katherine&rft.date=2006-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=17th+IBC+Antibody+Engineering+Conference&rft.issn=&rft_id=info:doi/ L2 - http://www.ibclifesciences.com/antibodyeng/2740.xml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Search for Tick Salivary Antigens Inducing Cellular Immunity using Reverse Antigen Screening T2 - 2006 Annual Meeting of the Entomological Society of America AN - 39338590; 4482465 JF - 2006 Annual Meeting of the Entomological Society of America AU - Anderson, Jennifer M AU - Miller, Nathan AU - Reynoso, David AU - Mather, Thomas N AU - Valenzuela, Jesus G Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Immunity (cell-mediated) KW - Antigens KW - Screening KW - Immunity KW - Ixodides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39338590?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=The+Search+for+Tick+Salivary+Antigens+Inducing+Cellular+Immunity+using+Reverse+Antigen+Screening&rft.au=Anderson%2C+Jennifer+M%3BMiller%2C+Nathan%3BReynoso%2C+David%3BMather%2C+Thomas+N%3BValenzuela%2C+Jesus+G&rft.aulast=Anderson&rft.aufirst=Jennifer&rft.date=2006-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2006/techprogram/meeting_2006.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Aspects of Leishmania Transmission by Sand Flies T2 - 2006 Annual Meeting of the Entomological Society of America AN - 39293123; 4482541 JF - 2006 Annual Meeting of the Entomological Society of America AU - Kamhawi, Shaden AU - Lawyer, Phillip G Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Sand KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293123?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+the+Entomological+Society+of+America&rft.atitle=Molecular+Aspects+of+Leishmania+Transmission+by+Sand+Flies&rft.au=Kamhawi%2C+Shaden%3BLawyer%2C+Phillip+G&rft.aulast=Kamhawi&rft.aufirst=Shaden&rft.date=2006-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+the+Entomological+Society+of+America&rft.issn=&rft_id=info:doi/ L2 - http://esa.confex.com/esa/2006/techprogram/meeting_2006.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaccines Against SARS-Coronavirus T2 - 2006 Keystone Symposia on Respiratory Viruses of Animals Causing Disease in Humans (E7) AN - 39275517; 4471567 JF - 2006 Keystone Symposia on Respiratory Viruses of Animals Causing Disease in Humans (E7) AU - Subbarao, Kanta Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Vaccines KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39275517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Respiratory+Viruses+of+Animals+Causing+Disease+in+Humans+%28E7%29&rft.atitle=Vaccines+Against+SARS-Coronavirus&rft.au=Subbarao%2C+Kanta&rft.aulast=Subbarao&rft.aufirst=Kanta&rft.date=2006-12-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Respiratory+Viruses+of+Animals+Causing+Disease+in+Humans+%28E7%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=81 9&subTab=program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Potent Human Monoclonal Antibodies Against SARS-CoV, Nipah and Hendra Viruses T2 - 17th IBC Antibody Engineering Conference AN - 39267870; 4508425 JF - 17th IBC 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N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polyreactive Antibodies are a Major Component of the Natural Antibody Repertoire: Properties and Function T2 - 17th IBC Antibody Engineering Conference AN - 39264306; 4508397 JF - 17th IBC Antibody Engineering Conference AU - Notkins, Abner Louis Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Antibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264306?accountid=14244 L2 - 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Baraouli Health District, Mali T2 - 2006 Annual Meeting of the Entomological Society of America AN - 39247313; 4482947 JF - 2006 Annual Meeting of the Entomological Society of America AU - Anderson, Jennifer M AU - Samake, Sibiry AU - Sissoko, Ibrahim Moussa AU - Coulibaly, Cheick Amadou AU - Sangare, Constance Souko AU - Traore, Sekou F AU - Kamhawi, Shaden AU - Lawyer, Phillip G AU - Oliveira, Fabiano AU - Keita, Somita AU - Traore, Pierre AU - Ousmane, Faye AU - Koureichi, Tall AU - Cisse, Moumine AU - Doumbia, Seydou AU - Valenzuela, Jesus G Y1 - 2006/12/10/ PY - 2006 DA - 2006 Dec 10 KW - Mali KW - Cutaneous leishmaniasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39247313?accountid=14244 L2 - 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the C-Terminal b sub(2) Determinant T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39358553; 4477441 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Lao, Q AU - Kobrinsky, E AU - Harry, J AU - Soldatov, N M Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Calcium channels KW - Calcium channels (voltage-gated) KW - Channel gating KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39358553?accountid=14244 L2 - 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sub(1A)-Adrenergic Receptor and Modulates its Effect on F-Actin Reorganization through Balancing ERK1/2 and p38 MAPK Pathway T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39352531; 4477845 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Zhang, T AU - Xu, Q. 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AU - Reid, E R AU - Mehta, A AU - Ralston, E Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Leaves KW - Golgi apparatus KW - Myogenesis KW - Inhibitors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Disrupted+Golgi+Complex+Reorganization+during+Myogenesis+by+GSK3-b+Inhibitors+Leaves+VSV-G+Trafficking+Intact&rft.au=Zaal%2C+K.J.M.%3BReid%2C+E+R%3BMehta%2C+A%3BRalston%2C+E&rft.aulast=Zaal&rft.aufirst=K.J.M.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nucleolar Transcription Levels Regulate Cell Cycle Dynamics of Condensin Distribution in the Yeast Genome T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39339373; 4479214 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Wang, B AU - Butylin, P AU - Basrai, M AU - Lichten, M AU - Strunnikov, A Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Genomes KW - Cell cycle KW - Transcription KW - Condensin KW - Nucleoli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39339373?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Nucleolar+Transcription+Levels+Regulate+Cell+Cycle+Dynamics+of+Condensin+Distribution+in+the+Yeast+Genome&rft.au=Wang%2C+B%3BButylin%2C+P%3BBasrai%2C+M%3BLichten%2C+M%3BStrunnikov%2C+A&rft.aulast=Wang&rft.aufirst=B&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Cell Imaging of Interactions between Hematopoietic Progenitor Cells and Osteoblastic Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39338254; 4480182 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Gillette, J M AU - Pruefer, F AU - Zhou, J AU - Lippincott-Schwartz, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Hemopoiesis KW - Imaging techniques KW - Osteoblasts KW - Osteoprogenitor cells KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39338254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Live+Cell+Imaging+of+Interactions+between+Hematopoietic+Progenitor+Cells+and+Osteoblastic+Cells&rft.au=Gillette%2C+J+M%3BPruefer%2C+F%3BZhou%2C+J%3BLippincott-Schwartz%2C+J&rft.aulast=Gillette&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tumor Formation via Loss of a Molecular Motor Involved in Maintenance of Chromosome Structure T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39335052; 4477578 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Mazumdar, M AU - Lee, J AU - Sengupta, K AU - Ried, T AU - Rane, S AU - Misteli, T Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Chromosomes KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39335052?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Tumor+Formation+via+Loss+of+a+Molecular+Motor+Involved+in+Maintenance+of+Chromosome+Structure&rft.au=Mazumdar%2C+M%3BLee%2C+J%3BSengupta%2C+K%3BRied%2C+T%3BRane%2C+S%3BMisteli%2C+T&rft.aulast=Mazumdar&rft.aufirst=M&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissection of the Pathway for Tail-Anchored Membrane Protein Insertion T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39311962; 4477880 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Stefanovic, S AU - Hegde, R S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Membrane proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39311962?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Dissection+of+the+Pathway+for+Tail-Anchored+Membrane+Protein+Insertion&rft.au=Stefanovic%2C+S%3BHegde%2C+R+S&rft.aulast=Stefanovic&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phosphatidylinositol 4-kinase III beta Regulates the Transport of Ceramide between the Endoplasmic Reticulum and Golgi T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39307912; 4477446 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Toth, B AU - Balla, A AU - Ma, H. AU - Knight, Z A AU - Shokat, K M AU - Balla, T Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - 1-Phosphatidylinositol 4-kinase KW - Golgi apparatus KW - Ceramide KW - Endoplasmic reticulum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39307912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Phosphatidylinositol+4-kinase+III+beta+Regulates+the+Transport+of+Ceramide+between+the+Endoplasmic+Reticulum+and+Golgi&rft.au=Toth%2C+B%3BBalla%2C+A%3BMa%2C+H.%3BKnight%2C+Z+A%3BShokat%2C+K+M%3BBalla%2C+T&rft.aulast=Toth&rft.aufirst=B&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lack of Erythropoietin Receptor in Non-hematopoietic Tissues Results in Insulin Resistance T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39306451; 4477179 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Teng, R AU - Gavrilova, O AU - Suzuki, N AU - Yamamoto, M AU - Noguchi, C Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Insulin KW - Erythropoietin receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Lack+of+Erythropoietin+Receptor+in+Non-hematopoietic+Tissues+Results+in+Insulin+Resistance&rft.au=Teng%2C+R%3BGavrilova%2C+O%3BSuzuki%2C+N%3BYamamoto%2C+M%3BNoguchi%2C+C&rft.aulast=Teng&rft.aufirst=R&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Cycle Dependent Changes in Mitochondrial Morphology T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39306324; 4478798 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Mitra, K AU - Lippincott-Schwartz, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Morphology KW - Mitochondria KW - Cell cycle KW - Cytology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Cell+Cycle+Dependent+Changes+in+Mitochondrial+Morphology&rft.au=Mitra%2C+K%3BLippincott-Schwartz%2C+J&rft.aulast=Mitra&rft.aufirst=K&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Type III Phosphatidylinositol 4-kinase a is Required for Pectoral Fin Development in Zebrafish T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39306261; 4477146 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Ma, H. AU - Blake, T AU - Liu, P AU - Balla, T Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - 1-Phosphatidylinositol 4-kinase KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39306261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Type+III+Phosphatidylinositol+4-kinase+a+is+Required+for+Pectoral+Fin+Development+in+Zebrafish&rft.au=Ma%2C+H.%3BBlake%2C+T%3BLiu%2C+P%3BBalla%2C+T&rft.aulast=Ma&rft.aufirst=H.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations of the Dynamin-Like GTPase Drp1 that Affect Self Assembly and Mitochondrial Morphology T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39305591; 4478010 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Chang, C AU - Stadler, J AU - Blackstone, C Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mutation KW - Morphology KW - Mitochondria KW - Guanosinetriphosphatase KW - Self KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39305591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mutations+of+the+Dynamin-Like+GTPase+Drp1+that+Affect+Self+Assembly+and+Mitochondrial+Morphology&rft.au=Chang%2C+C%3BStadler%2C+J%3BBlackstone%2C+C&rft.aulast=Chang&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Seeing More by Seeing Less: New Actin Cytoskeletal Dynamics Revealed by Photoactivatible Thresholding T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39302293; 4477686 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Galbraith, C G AU - Galbraith, J A Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Cytoskeleton KW - Actin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39302293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Seeing+More+by+Seeing+Less%3A+New+Actin+Cytoskeletal+Dynamics+Revealed+by+Photoactivatible+Thresholding&rft.au=Galbraith%2C+C+G%3BGalbraith%2C+J+A&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tyr53-Phosphorylation of Dictyostelium Actin Inhibits Filament Nucleation, Elongation, and Stability T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39299810; 4478889 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Liu, X AU - Shu, S AU - Hong, M AU - Levine, R L AU - Korn, E D Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Nucleation KW - Actin KW - Filaments KW - Elongation KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39299810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Tyr53-Phosphorylation+of+Dictyostelium+Actin+Inhibits+Filament+Nucleation%2C+Elongation%2C+and+Stability&rft.au=Liu%2C+X%3BShu%2C+S%3BHong%2C+M%3BLevine%2C+R+L%3BKorn%2C+E+D&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Transgenic Mice Expressing HA-GLUT4-GFP in Muscle T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39298292; 4477869 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Lisinski, I AU - Yver, D AU - Al-Hasani, H AU - Holman, G D AU - Cushman, S W Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mice KW - Muscles KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Characterization+of+Transgenic+Mice+Expressing+HA-GLUT4-GFP+in+Muscle&rft.au=Lisinski%2C+I%3BYver%2C+D%3BAl-Hasani%2C+H%3BHolman%2C+G+D%3BCushman%2C+S+W&rft.aulast=Lisinski&rft.aufirst=I&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Lamin A-Dependent Nuclear Defects in Human Aging T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39298218; 4479813 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Scaffidi, P AU - Misteli, T Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Aging KW - Lamins KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Lamin+A-Dependent+Nuclear+Defects+in+Human+Aging&rft.au=Scaffidi%2C+P%3BMisteli%2C+T&rft.aulast=Scaffidi&rft.aufirst=P&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Critical Roles of ATF3 on Streptozotocin-Induced Diabetic Liver Injury in Mouse: ATF3 Mediates STAT1 Overexpression T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39297780; 4478141 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Lee, S AU - Lee, H AU - Oh, Y. AU - Mo, J. AU - Kwon, Y AU - Park, S AU - Kim, W Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Injuries KW - Liver KW - Activating transcription factor 3 KW - Stat1 protein KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39297780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Critical+Roles+of+ATF3+on+Streptozotocin-Induced+Diabetic+Liver+Injury+in+Mouse%3A+ATF3+Mediates+STAT1+Overexpression&rft.au=Lee%2C+S%3BLee%2C+H%3BOh%2C+Y.%3BMo%2C+J.%3BKwon%2C+Y%3BPark%2C+S%3BKim%2C+W&rft.aulast=Lee&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mucolipin-2 Localizes to the Arf6-Associated Pathway and Regulates Trafficking of GPI-Proteins T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39296322; 4477318 DE: JF - 46th Annual Meeting of the American Society for Cell Biology AU - Karacsonyi, C V AU - Miguel, A San AU - Puertollano, R Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39296322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mucolipin-2+Localizes+to+the+Arf6-Associated+Pathway+and+Regulates+Trafficking+of+GPI-Proteins&rft.au=Karacsonyi%2C+C+V%3BMiguel%2C+A+San%3BPuertollano%2C+R&rft.aulast=Karacsonyi&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism of Alternative Splicing of Nonmuscle Myosin Heavy Chain II-B and II-C Pre-mRNAs: Role of Fox-1 Family Proteins T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39295940; 4479530 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Nakahata, S AU - Kawamoto, S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Myosin KW - Alternative splicing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39295940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mechanism+of+Alternative+Splicing+of+Nonmuscle+Myosin+Heavy+Chain+II-B+and+II-C+Pre-mRNAs%3A+Role+of+Fox-1+Family+Proteins&rft.au=Nakahata%2C+S%3BKawamoto%2C+S&rft.aulast=Nakahata&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pkd1L3 and Pkd2L1, Two Members of the TRP Family of Ion Channels, are Co-Expressed in a Subset of Taste Receptor Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39292078; 4478476 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Jimenez, N.D. Lopez AU - Cavenagh, M M AU - Sainz, E AU - Cruz-Ithier, M A AU - Battey, J F AU - Sullivan, S L Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Channels KW - Ion channels KW - Taste receptor neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Pkd1L3+and+Pkd2L1%2C+Two+Members+of+the+TRP+Family+of+Ion+Channels%2C+are+Co-Expressed+in+a+Subset+of+Taste+Receptor+Cells&rft.au=Jimenez%2C+N.D.+Lopez%3BCavenagh%2C+M+M%3BSainz%2C+E%3BCruz-Ithier%2C+M+A%3BBattey%2C+J+F%3BSullivan%2C+S+L&rft.aulast=Jimenez&rft.aufirst=N.D.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Homogeneous Mutant Collagen in Brtl/Mov Compound Mice is Associated with a Milder Osteogenesis Imperfecta Phenotype than Occurs in Heterozygous Brtl/+ Mice, Despite Increased Matrix Insufficiency Due to the Mov13 Null Allele T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39291248; 4477769 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Uveges, T E AU - Meganck, J A AU - Daley, E.L.H. AU - Goldstein, S A AU - Marini, J C Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mice KW - Mutants KW - Osteogenesis imperfecta KW - Collagen KW - Allelles KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39291248?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Homogeneous+Mutant+Collagen+in+Brtl%2FMov+Compound+Mice+is+Associated+with+a+Milder+Osteogenesis+Imperfecta+Phenotype+than+Occurs+in+Heterozygous+Brtl%2F%2B+Mice%2C+Despite+Increased+Matrix+Insufficiency+Due+to+the+Mov13+Null+Allele&rft.au=Uveges%2C+T+E%3BMeganck%2C+J+A%3BDaley%2C+E.L.H.%3BGoldstein%2C+S+A%3BMarini%2C+J+C&rft.aulast=Uveges&rft.aufirst=T&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Quantitative Differential Sulfation Pattern of Chondroitin Regulates Axonal Guidance T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39290926; 4477781 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Katagiri, Y AU - Wang, H AU - McCann, T AU - Yu, Z. AU - Tan, F AU - Unsworth, E AU - Goldsmith, P AU - Wang, Y AU - Symes, A AU - Geller, H M Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Axon guidance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Quantitative+Differential+Sulfation+Pattern+of+Chondroitin+Regulates+Axonal+Guidance&rft.au=Katagiri%2C+Y%3BWang%2C+H%3BMcCann%2C+T%3BYu%2C+Z.%3BTan%2C+F%3BUnsworth%2C+E%3BGoldsmith%2C+P%3BWang%2C+Y%3BSymes%2C+A%3BGeller%2C+H+M&rft.aulast=Katagiri&rft.aufirst=Y&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Cdk5 Sustains Mapk (Erk1/2) Activation in Cortical Neurons and Induces Apoptosis T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39290254; 4477004 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Zheng, Y AU - Li, B. AU - Kanungo, J AU - Kesavapany, S AU - Amin, N AU - Grant, P AU - Pant, H C Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - MAP kinase KW - Apoptosis KW - Cyclin-dependent kinase 5 KW - Cortex KW - Extracellular signal-regulated kinase KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Inhibition+of+Cdk5+Sustains+Mapk+%28Erk1%2F2%29+Activation+in+Cortical+Neurons+and+Induces+Apoptosis&rft.au=Zheng%2C+Y%3BLi%2C+B.%3BKanungo%2C+J%3BKesavapany%2C+S%3BAmin%2C+N%3BGrant%2C+P%3BPant%2C+H+C&rft.aulast=Zheng&rft.aufirst=Y&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inhibition of Cyclin Dependent Kinase 5 (Cdk5) Regulates E-cadherin Degradation and Trafficking in Madin-Darby Canine Kidney (MDCK) Epithelial Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39290159; 4477811 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Saravanamuthu, S S AU - Gao, C Y AU - Zelenka, P S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Kidneys KW - Epithelial cells KW - Cyclin-dependent kinase 5 KW - E-Cadherin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290159?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Inhibition+of+Cyclin+Dependent+Kinase+5+%28Cdk5%29+Regulates+E-cadherin+Degradation+and+Trafficking+in+Madin-Darby+Canine+Kidney+%28MDCK%29+Epithelial+Cells&rft.au=Saravanamuthu%2C+S+S%3BGao%2C+C+Y%3BZelenka%2C+P+S&rft.aulast=Saravanamuthu&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Progerin, the Abnormal Protein Expressed in Hutchinson-Gilford Progeria Syndrome, Interferes with Mitosis in Both Progeria and Normal Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39289417; 4479988 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Cao, K AU - Capell, B AU - Erdos, M AU - Djabali, K AU - Collins, F Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Progeria KW - Mitosis KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39289417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Progerin%2C+the+Abnormal+Protein+Expressed+in+Hutchinson-Gilford+Progeria+Syndrome%2C+Interferes+with+Mitosis+in+Both+Progeria+and+Normal+Cells&rft.au=Cao%2C+K%3BCapell%2C+B%3BErdos%2C+M%3BDjabali%2C+K%3BCollins%2C+F&rft.aulast=Cao&rft.aufirst=K&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determinants of the Interaction of GAK/Auxilin-2 with the AP-1 Complex T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39289029; 4479915 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Kametaka, S AU - Moriyama, K AU - Burgos, P AU - Greene, L AU - Eisenberg, E AU - Bonifacino, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Lysosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39289029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Determinants+of+the+Interaction+of+GAK%2FAuxilin-2+with+the+AP-1+Complex&rft.au=Kametaka%2C+S%3BMoriyama%2C+K%3BBurgos%2C+P%3BGreene%2C+L%3BEisenberg%2C+E%3BBonifacino%2C+J&rft.aulast=Kametaka&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In cellula Pulse-Chase Experiments with Photoactivatable Proteins Reveal Stress-Dependent Turnover Kinetics of Autophagosomes T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39288965; 4479910 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Hailey, D W AU - Lippincott-Schwartz, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Kinetics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39288965?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=In+cellula+Pulse-Chase+Experiments+with+Photoactivatable+Proteins+Reveal+Stress-Dependent+Turnover+Kinetics+of+Autophagosomes&rft.au=Hailey%2C+D+W%3BLippincott-Schwartz%2C+J&rft.aulast=Hailey&rft.aufirst=D&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of SZY-5 in C. elegans Centrosome Duplication T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39287976; 4478378 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Miliaras, N B AU - Addepalli, M K AU - O'Connell, K F Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Role+of+SZY-5+in+C.+elegans+Centrosome+Duplication&rft.au=Miliaras%2C+N+B%3BAddepalli%2C+M+K%3BO%27Connell%2C+K+F&rft.aulast=Miliaras&rft.aufirst=N&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Leishmania Kinesin with a Potential Role in Kinetoplast Morphology T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39287684; 4478278 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Gerald, N J AU - Coppens, I AU - Dwyer, D M Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Morphology KW - Kinetoplasts KW - Kinesin KW - Leishmania KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Novel+Leishmania+Kinesin+with+a+Potential+Role+in+Kinetoplast+Morphology&rft.au=Gerald%2C+N+J%3BCoppens%2C+I%3BDwyer%2C+D+M&rft.aulast=Gerald&rft.aufirst=N&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Gingival Fibroblasts Carried SOS1 Mutation on 3-D Collagen Matrices T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39285184; 4479661 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Jang, S AU - Lee, E AU - Pallos, D AU - Hart, T C Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mutation KW - Fibroblasts KW - Gingiva KW - Collagen KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39285184?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Effects+of+Gingival+Fibroblasts+Carried+SOS1+Mutation+on+3-D+Collagen+Matrices&rft.au=Jang%2C+S%3BLee%2C+E%3BPallos%2C+D%3BHart%2C+T+C&rft.aulast=Jang&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SZY-20 Regulates Centrosome Size and Centriole Assembly in C. elegans T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39284703; 4478187 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Song, M AU - O'Connell, K F Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Centrioles KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39284703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=SZY-20+Regulates+Centrosome+Size+and+Centriole+Assembly+in+C.+elegans&rft.au=Song%2C+M%3BO%27Connell%2C+K+F&rft.aulast=Song&rft.aufirst=M&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Mesothelin is Increased by Taxol at the G sub(2)/M Phase of Cell Cycle in Human Lung Carcinoma Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39284365; 4479467 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Ho, M. AU - Bera, T AU - Willingham, M AU - Onda, M AU - Hassan, R AU - FitzGerald, D AU - Pastan, I Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Lung KW - Taxol KW - Cell cycle KW - Lung carcinoma KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39284365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Expression+of+Mesothelin+is+Increased+by+Taxol+at+the+G+sub%282%29%2FM+Phase+of+Cell+Cycle+in+Human+Lung+Carcinoma+Cells&rft.au=Ho%2C+M.%3BBera%2C+T%3BWillingham%2C+M%3BOnda%2C+M%3BHassan%2C+R%3BFitzGerald%2C+D%3BPastan%2C+I&rft.aulast=Ho&rft.aufirst=M.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of a Novel Gene, Jxc1, Which is Associated with the Development of Hearing in Mouse T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39280930; 4477460 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Chen, Z AU - Noben-Trauth, K Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Hearing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39280930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Characterization+of+a+Novel+Gene%2C+Jxc1%2C+Which+is+Associated+with+the+Development+of+Hearing+in+Mouse&rft.au=Chen%2C+Z%3BNoben-Trauth%2C+K&rft.aulast=Chen&rft.aufirst=Z&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Function of the C1 Inserted Isoform of Nonmuscle Myosin II-C in Tumor Cell Lines and Mice T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39279402; 4480167 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Jana, S S AU - Adelstein, R S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mice KW - Myosin KW - Tumor cell lines KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39279402?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Function+of+the+C1+Inserted+Isoform+of+Nonmuscle+Myosin+II-C+in+Tumor+Cell+Lines+and+Mice&rft.au=Jana%2C+S+S%3BAdelstein%2C+R+S&rft.aulast=Jana&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - H-Ras Traffics through and Regulates Clathrin-Independent Endocytosis T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39279097; 4479146 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Porat-Shliom, N AU - Kloog, Y AU - Donaldson, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Endocytosis KW - Traffic KW - H-Ras protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39279097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=H-Ras+Traffics+through+and+Regulates+Clathrin-Independent+Endocytosis&rft.au=Porat-Shliom%2C+N%3BKloog%2C+Y%3BDonaldson%2C+J&rft.aulast=Porat-Shliom&rft.aufirst=N&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - CAPC is Associated with Intermediate Filament Cytokeratin18 and Expression of CAPC Stimulates Malignant Phenotypes In Vitro T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39275808; 4479031 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Liu, X AU - Bera, T AU - Ha, D. AU - Man, Y AU - Lee, B AU - Pastan, I Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Intermediate filaments KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39275808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=CAPC+is+Associated+with+Intermediate+Filament+Cytokeratin18+and+Expression+of+CAPC+Stimulates+Malignant+Phenotypes+In+Vitro&rft.au=Liu%2C+X%3BBera%2C+T%3BHa%2C+D.%3BMan%2C+Y%3BLee%2C+B%3BPastan%2C+I&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Requirement of hCenexin for Proper Mitotic Functions of Polo-Like Kinase 1 at the Centrosomes T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39275634; 4478188 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Soung, N AU - Kang, Y H AU - Kamijo, K AU - Seong, Y AU - Kuo, Y AU - Miki, T AU - Kim, S R AU - Kuriyama, R AU - Giam, C AU - Lee, K S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Polo-like kinase 1 KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39275634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Requirement+of+hCenexin+for+Proper+Mitotic+Functions+of+Polo-Like+Kinase+1+at+the+Centrosomes&rft.au=Soung%2C+N%3BKang%2C+Y+H%3BKamijo%2C+K%3BSeong%2C+Y%3BKuo%2C+Y%3BMiki%2C+T%3BKim%2C+S+R%3BKuriyama%2C+R%3BGiam%2C+C%3BLee%2C+K+S&rft.aulast=Soung&rft.aufirst=N&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Interferon Response Factor 8 (IRF8) in Development of Follicular Dendritic Cells of IRF8 Knock Out Mice T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39274617; 4478667 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Qi, C. Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mice KW - Interferon KW - Dendritic cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39274617?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+of+Interferon+Response+Factor+8+%28IRF8%29+in+Development+of+Follicular+Dendritic+Cells+of+IRF8+Knock+Out+Mice&rft.au=Qi%2C+C.&rft.aulast=Qi&rft.aufirst=C.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visualization of the Endoplasmic Reticulum-Associated Degradation of CD3delta T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39273974; 4477882 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Lorenz, H AU - Lippincott-Schwartz, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Protein folding KW - Endoplasmic reticulum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39273974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Visualization+of+the+Endoplasmic+Reticulum-Associated+Degradation+of+CD3delta&rft.au=Lorenz%2C+H%3BLippincott-Schwartz%2C+J&rft.aulast=Lorenz&rft.aufirst=H&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Self-Regulated Plk1 Recruitment to Kinetochores by the Plk1-PBIP1 Interaction is Critical for Proper Chromosome Segregation T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39273655; 4478201 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Kang, Y H AU - Park, J AU - Yu, L. AU - Soung, N AU - Yun, S AU - Bang, J K AU - Seong, Y AU - Yu, H. AU - Garfield, S AU - Veenstra, T D AU - Lee, K S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Recruitment KW - Chromosomes KW - Kinetochores KW - Polo-like kinase 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39273655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Self-Regulated+Plk1+Recruitment+to+Kinetochores+by+the+Plk1-PBIP1+Interaction+is+Critical+for+Proper+Chromosome+Segregation&rft.au=Kang%2C+Y+H%3BPark%2C+J%3BYu%2C+L.%3BSoung%2C+N%3BYun%2C+S%3BBang%2C+J+K%3BSeong%2C+Y%3BYu%2C+H.%3BGarfield%2C+S%3BVeenstra%2C+T+D%3BLee%2C+K+S&rft.aulast=Kang&rft.aufirst=Y&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of STAT1/IRF-1 on Hepatic Liver Injury Induced by LPS/D-Galactosamine T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39273463; 4478140 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Lee, H AU - Oh, Y. AU - Lee, S AU - Kwon, Y AU - Park, S AU - Kim, W Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Injuries KW - Liver KW - D-Galactosamine KW - Lipopolysaccharides KW - Interferon regulatory factor 1 KW - Stat1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39273463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Role+of+STAT1%2FIRF-1+on+Hepatic+Liver+Injury+Induced+by+LPS%2FD-Galactosamine&rft.au=Lee%2C+H%3BOh%2C+Y.%3BLee%2C+S%3BKwon%2C+Y%3BPark%2C+S%3BKim%2C+W&rft.aulast=Lee&rft.aufirst=H&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Keeps Reticulons in the Peripheral ER? T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39272304; 4477337 DE: JF - 46th Annual Meeting of the American Society for Cell Biology AU - Voss, C AU - Prinz, W Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39272304?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=What+Keeps+Reticulons+in+the+Peripheral+ER%3F&rft.au=Voss%2C+C%3BPrinz%2C+W&rft.aulast=Voss&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanosensory Signal Transduction: Potential Mechanism for Induction of Sperm Acrosome Exocytosis T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39270700; 4477949 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Baibakov, B AU - Gauthier, L AU - Rankin, T L AU - Talbot, P AU - Dean, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Signal transduction KW - Exocytosis KW - Acrosomes KW - Sperm KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270700?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mechanosensory+Signal+Transduction%3A+Potential+Mechanism+for+Induction+of+Sperm+Acrosome+Exocytosis&rft.au=Baibakov%2C+B%3BGauthier%2C+L%3BRankin%2C+T+L%3BTalbot%2C+P%3BDean%2C+J&rft.aulast=Baibakov&rft.aufirst=B&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mosaic Eyes Stabilizes Delta and Restricts Notch Acitvity to Rhombomere Boundaries T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39269902; 4478090 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Rand, K AU - Itoh, M AU - Yeo, S AU - Palardy, G AU - Chitnis, A B Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Deltas KW - Notch protein KW - Mosaics KW - Boundaries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39269902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Mosaic+Eyes+Stabilizes+Delta+and+Restricts+Notch+Acitvity+to+Rhombomere+Boundaries&rft.au=Rand%2C+K%3BItoh%2C+M%3BYeo%2C+S%3BPalardy%2C+G%3BChitnis%2C+A+B&rft.aulast=Rand&rft.aufirst=K&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction between Heterotrimeric Gialpha Proteins and their Regulator, RGS14 in the Mammalian Centrosomes T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39269497; 4477063 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Cho, H AU - Kehr, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Centrosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39269497?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Interaction+between+Heterotrimeric+Gialpha+Proteins+and+their+Regulator%2C+RGS14+in+the+Mammalian+Centrosomes&rft.au=Cho%2C+H%3BKehr%2C+J&rft.aulast=Cho&rft.aufirst=H&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bub1 is Essential for Assembly of the Inner Centromere T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39269071; 4480049 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Boyarchuk, Y AU - Salic, A AU - Dasso, M AU - Arnaoutov, A Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Centromeres KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39269071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Bub1+is+Essential+for+Assembly+of+the+Inner+Centromere&rft.au=Boyarchuk%2C+Y%3BSalic%2C+A%3BDasso%2C+M%3BArnaoutov%2C+A&rft.aulast=Boyarchuk&rft.aufirst=Y&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role and Regulation of Barx1 in the Zebrafish Pharyngeal Arches T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39267226; 4477330 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Sperber, S M AU - Dawid, I B Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Pharynx KW - Freshwater fish KW - Danio rerio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39267226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Role+and+Regulation+of+Barx1+in+the+Zebrafish+Pharyngeal+Arches&rft.au=Sperber%2C+S+M%3BDawid%2C+I+B&rft.aulast=Sperber&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Double Knockout Nonmuscle Myosin II-B and II-C Mice to Study Cardiac Myocyte Development T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39264311; 4479531 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Ma, X. AU - Kawamoto, S AU - Homayounfar, G AU - Adelstein, R S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mice KW - Cardiomyocytes KW - Myosin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Using+Double+Knockout+Nonmuscle+Myosin+II-B+and+II-C+Mice+to+Study+Cardiac+Myocyte+Development&rft.au=Ma%2C+X.%3BKawamoto%2C+S%3BHomayounfar%2C+G%3BAdelstein%2C+R+S&rft.aulast=Ma&rft.aufirst=X.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - From Birth to Death: Systematic Comparative Analysis of the Fate of Disease-Causing PrP Mutants T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39260738; 4478726 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Ashok, A AU - Hegde, R S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mortality KW - Mutants KW - Birth KW - Parturition KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=From+Birth+to+Death%3A+Systematic+Comparative+Analysis+of+the+Fate+of+Disease-Causing+PrP+Mutants&rft.au=Ashok%2C+A%3BHegde%2C+R+S&rft.aulast=Ashok&rft.aufirst=A&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trans-Acting Modifiers of Protein Aggregate Dynamics in the Cytosol T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39260634; 4478725 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Chakrabarti, O AU - Rane, N S AU - Hegde, R S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Cytosol KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Trans-Acting+Modifiers+of+Protein+Aggregate+Dynamics+in+the+Cytosol&rft.au=Chakrabarti%2C+O%3BRane%2C+N+S%3BHegde%2C+R+S&rft.aulast=Chakrabarti&rft.aufirst=O&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Essential Role of Syntaphilin in the Control of Axonal Mitochondrial Motility T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39260336; 4478022 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Kang, J AU - Tian, J AU - Zald, P AU - Pan, P AU - Li, C. AU - Deng, C AU - Sheng, Z Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Motility KW - Mitochondria KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260336?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Essential+Role+of+Syntaphilin+in+the+Control+of+Axonal+Mitochondrial+Motility&rft.au=Kang%2C+J%3BTian%2C+J%3BZald%2C+P%3BPan%2C+P%3BLi%2C+C.%3BDeng%2C+C%3BSheng%2C+Z&rft.aulast=Kang&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploring Syncytium Formation and Subsequent Cellular Reorganization T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39258032; 4479753 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Richard, J P AU - Leikina, E AU - Chernomordik, L V Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Membrane fusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Exploring+Syncytium+Formation+and+Subsequent+Cellular+Reorganization&rft.au=Richard%2C+J+P%3BLeikina%2C+E%3BChernomordik%2C+L+V&rft.aulast=Richard&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fusion between Nuclear Membrane Vesicles and Protein-Free Liposomes Results in Nuclear Assembly T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39256500; 4477327 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Rafikova, E AU - Melikov, K AU - Ramos, C AU - Chernomordik, L Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Nuclear membranes KW - Membrane vesicles KW - Membrane fusion KW - Liposomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39256500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Fusion+between+Nuclear+Membrane+Vesicles+and+Protein-Free+Liposomes+Results+in+Nuclear+Assembly&rft.au=Rafikova%2C+E%3BMelikov%2C+K%3BRamos%2C+C%3BChernomordik%2C+L&rft.aulast=Rafikova&rft.aufirst=E&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Elasticity and Molecular Construct of Clathrin Coated Vesicles via Atomic Force Microscopy T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39254470; 4478505 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Jin, A J AU - Prasad, K AU - Smith, P D AU - Lafer, E M AU - Nossal, R J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Atomic force microscopy KW - Clathrin KW - Coated vesicles KW - Elasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39254470?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Elasticity+and+Molecular+Construct+of+Clathrin+Coated+Vesicles+via+Atomic+Force+Microscopy&rft.au=Jin%2C+A+J%3BPrasad%2C+K%3BSmith%2C+P+D%3BLafer%2C+E+M%3BNossal%2C+R+J&rft.aulast=Jin&rft.aufirst=A&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Localization of Pdlim2 at Cell-Matrix Adhesion Sites Requires an Intact Actin Cytoskeleton and Rho Activity T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39252885; 4477771 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Gao, C Y AU - Sun, D AU - Tomarev, S AU - Zelenka, P Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Cytoskeleton KW - Actin KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39252885?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Localization+of+Pdlim2+at+Cell-Matrix+Adhesion+Sites+Requires+an+Intact+Actin+Cytoskeleton+and+Rho+Activity&rft.au=Gao%2C+C+Y%3BSun%2C+D%3BTomarev%2C+S%3BZelenka%2C+P&rft.aulast=Gao&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - S-Adenosylhomocysteine Hydrolase Concentration with F-Actin at the Front of Chemotaxing Dictyostelium and Neutrophils Suggests a Role for Transmethylation during Chemotaxis T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39252695; 4477698 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Shu, S AU - Liu, X AU - Mahadeo, D AU - Parent, C A AU - Liu, W AU - Korn, E D Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Chemotaxis KW - Actin KW - Hydrolase KW - Leukocytes (neutrophilic) KW - Dictyostelium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39252695?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=S-Adenosylhomocysteine+Hydrolase+Concentration+with+F-Actin+at+the+Front+of+Chemotaxing+Dictyostelium+and+Neutrophils+Suggests+a+Role+for+Transmethylation+during+Chemotaxis&rft.au=Shu%2C+S%3BLiu%2C+X%3BMahadeo%2C+D%3BParent%2C+C+A%3BLiu%2C+W%3BKorn%2C+E+D&rft.aulast=Shu&rft.aufirst=S&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Coordinate Regulation of Gia, RGS1, and CXCR4 in B Lymphocyte Chemotaxis T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39252202; 4476936 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Huang, N AU - Shi, C AU - Hwang, I AU - Kehr, J H Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Lymphocytes KW - Lymphocytes B KW - CXCR4 protein KW - Chemotaxis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39252202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Coordinate+Regulation+of+Gia%2C+RGS1%2C+and+CXCR4+in+B+Lymphocyte+Chemotaxis&rft.au=Huang%2C+N%3BShi%2C+C%3BHwang%2C+I%3BKehr%2C+J+H&rft.aulast=Huang&rft.aufirst=N&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adenosine 2,3-dialdehyde (AdOx) Causes Reactivation of p53 and Induction of the G2/M Checkpoint Resulting in Programmed Cell Death in HTLV-1 Transformed Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39248834; 4477493 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Dasgupta, A AU - Jeong, S AU - Jung, K AU - Brady, J N Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mortality KW - Apoptosis KW - P53 protein KW - Adenosine KW - Transformed cells KW - Human T-lymphotropic virus 1 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39248834?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Adenosine+2%2C3-dialdehyde+%28AdOx%29+Causes+Reactivation+of+p53+and+Induction+of+the+G2%2FM+Checkpoint+Resulting+in+Programmed+Cell+Death+in+HTLV-1+Transformed+Cells&rft.au=Dasgupta%2C+A%3BJeong%2C+S%3BJung%2C+K%3BBrady%2C+J+N&rft.aulast=Dasgupta&rft.aufirst=A&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The GARP (Vps52-Vps53-Vps54) Complex is Essential for Transport from Endosomes to the TGN in Mammalian Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39248076; 4479894 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Perez-Victoria, F J AU - Bonifacino, J S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Mammalian cells KW - Endosomes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39248076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+GARP+%28Vps52-Vps53-Vps54%29+Complex+is+Essential+for+Transport+from+Endosomes+to+the+TGN+in+Mammalian+Cells&rft.au=Perez-Victoria%2C+F+J%3BBonifacino%2C+J+S&rft.aulast=Perez-Victoria&rft.aufirst=F&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of NK Cell Inhibitory Receptor Clustering by FRET T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39246035; 4479705 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Srinivasan, P AU - Long, E O Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Fluorescence resonance energy transfer KW - Receptor density KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Analysis+of+NK+Cell+Inhibitory+Receptor+Clustering+by+FRET&rft.au=Srinivasan%2C+P%3BLong%2C+E+O&rft.aulast=Srinivasan&rft.aufirst=P&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Active Arf6 Recruits ARNO/Cytohesin GEFS to the PM through an Interaction with their PH Domains Leading to Sequential Arf Activation T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39244268; 4479148 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Cohen, L A AU - Varnai, P AU - Honda, A AU - Balla, T AU - Donaldson, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - PH KW - Recruitment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39244268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Active+Arf6+Recruits+ARNO%2FCytohesin+GEFS+to+the+PM+through+an+Interaction+with+their+PH+Domains+Leading+to+Sequential+Arf+Activation&rft.au=Cohen%2C+L+A%3BVarnai%2C+P%3BHonda%2C+A%3BBalla%2C+T%3BDonaldson%2C+J&rft.aulast=Cohen&rft.aufirst=L&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Three-Dimensional Visualization of Cell and Tissue Architecture using Dual Beam Electron Microscopy T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39243688; 4479883 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Heymann, J AU - Subramaniam, S Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Electron microscopy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39243688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Three-Dimensional+Visualization+of+Cell+and+Tissue+Architecture+using+Dual+Beam+Electron+Microscopy&rft.au=Heymann%2C+J%3BSubramaniam%2C+S&rft.aulast=Heymann&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Live Cell Assay to Visualize the Activation of Integrin Adhesion Receptors T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39242542; 4478405 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Galbraith, J A AU - Galbraith, C G Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Integrins KW - Adhesion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39242542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Live+Cell+Assay+to+Visualize+the+Activation+of+Integrin+Adhesion+Receptors&rft.au=Galbraith%2C+J+A%3BGalbraith%2C+C+G&rft.aulast=Galbraith&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Clathrin- and Lipid Raft Independent Macropinocytic Pathway for Internalization of the CD94/NKG2A Inhibitory Receptor in Natural Killer Cells T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39240935; 4479145 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Masilamani, M AU - Prieto, M E AU - Borrego, F AU - Coligan, J E Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Lipid rafts KW - Natural killer cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=A+Novel+Clathrin-+and+Lipid+Raft+Independent+Macropinocytic+Pathway+for+Internalization+of+the+CD94%2FNKG2A+Inhibitory+Receptor+in+Natural+Killer+Cells&rft.au=Masilamani%2C+M%3BPrieto%2C+M+E%3BBorrego%2C+F%3BColigan%2C+J+E&rft.aulast=Masilamani&rft.aufirst=M&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Krp1, a Muscle-Specific Kelch-Related Protein, is Required for Mature Myofibril Accumulation in Primary Mouse Embryonic Cardiomyocytes T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39240859; 4479542 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Greenberg, C C AU - Horowits, R Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Cardiomyocytes KW - Kelch-related protein KW - Embryos KW - Myofibrils KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Krp1%2C+a+Muscle-Specific+Kelch-Related+Protein%2C+is+Required+for+Mature+Myofibril+Accumulation+in+Primary+Mouse+Embryonic+Cardiomyocytes&rft.au=Greenberg%2C+C+C%3BHorowits%2C+R&rft.aulast=Greenberg&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mammary Stem Cell Niche Modifies Neural Stem Cell Repertoire T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39240598; 4480180 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Boulanger, C A AU - Androutsellis-Theotokis, A AU - Booth, B W AU - Mack, D L AU - McKay, R AU - Smith, G H Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Stem cells KW - Niches KW - Neural stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240598?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+Mammary+Stem+Cell+Niche+Modifies+Neural+Stem+Cell+Repertoire&rft.au=Boulanger%2C+C+A%3BAndroutsellis-Theotokis%2C+A%3BBooth%2C+B+W%3BMack%2C+D+L%3BMcKay%2C+R%3BSmith%2C+G+H&rft.aulast=Boulanger&rft.aufirst=C&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo and In Vitro Studies on SENP1 SUMO Protease T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39236500; 4479225 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Kametaka, A AU - Mukhopadhyay, D AU - Kolli, N AU - Wilkinson, K AU - Dasso, M Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Proteinase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39236500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=In+Vivo+and+In+Vitro+Studies+on+SENP1+SUMO+Protease&rft.au=Kametaka%2C+A%3BMukhopadhyay%2C+D%3BKolli%2C+N%3BWilkinson%2C+K%3BDasso%2C+M&rft.aulast=Kametaka&rft.aufirst=A&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Diphtheria Toxin Alters Endosome Morphology during Translocation T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39236343; 4479143 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Antignani, A AU - Youle, R Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Translocation KW - Toxins KW - Morphology KW - Endosomes KW - Diphtheria toxin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39236343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Diphtheria+Toxin+Alters+Endosome+Morphology+during+Translocation&rft.au=Antignani%2C+A%3BYoule%2C+R&rft.aulast=Antignani&rft.aufirst=A&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production of a Human Artificial Chromosome with a Conditional Centromere T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39232794; 4478841 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Nakano, M AU - Cardinale, S AU - Noskov, V N AU - Gassmann, R AU - Vagnarelli, P AU - Kandels-Lewis, S AU - Larionov, V AU - Earnshaw, W C AU - Masumoto, H Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Chromosomes KW - Human artificial chromosomes KW - Centromeres KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39232794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Production+of+a+Human+Artificial+Chromosome+with+a+Conditional+Centromere&rft.au=Nakano%2C+M%3BCardinale%2C+S%3BNoskov%2C+V+N%3BGassmann%2C+R%3BVagnarelli%2C+P%3BKandels-Lewis%2C+S%3BLarionov%2C+V%3BEarnshaw%2C+W+C%3BMasumoto%2C+H&rft.aulast=Nakano&rft.aufirst=M&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vegf Controls Endothelial Cell Permeability by Promoting the Rac-Dependent Endocytosis of Ve-Cadherin T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39219096; 4476958 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Gavard, J AU - Gutkind, J Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Permeability KW - Endocytosis KW - Endothelial cells KW - Vascular endothelial growth factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39219096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Vegf+Controls+Endothelial+Cell+Permeability+by+Promoting+the+Rac-Dependent+Endocytosis+of+Ve-Cadherin&rft.au=Gavard%2C+J%3BGutkind%2C+J&rft.aulast=Gavard&rft.aufirst=J&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The CREB-Binding Protein has a Dual Effect on Ezrin Gene Transcription T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39217714; 4479823 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Yu, Y. AU - Merlino, G Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Transcription KW - Ezrin KW - CREB-binding protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39217714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=The+CREB-Binding+Protein+has+a+Dual+Effect+on+Ezrin+Gene+Transcription&rft.au=Yu%2C+Y.%3BMerlino%2C+G&rft.aulast=Yu&rft.aufirst=Y.&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Characterization and Functional Analyses of a Unique, Class-I, Secretory Nuclease from the Human Pathogen, Leishmania donovani T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39212694; 4479312 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Joshi, M B AU - Dwyer, D M Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Pathogens KW - Nuclease KW - Functional analysis KW - Leishmania donovani KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Molecular+Characterization+and+Functional+Analyses+of+a+Unique%2C+Class-I%2C+Secretory+Nuclease+from+the+Human+Pathogen%2C+Leishmania+donovani&rft.au=Joshi%2C+M+B%3BDwyer%2C+D+M&rft.aulast=Joshi&rft.aufirst=M&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acanthamoeba Myosin IC has Equal Affinity for Phosphatidylserine and Phosphatidylinositol Bisphosphate T2 - 46th Annual Meeting of the American Society for Cell Biology AN - 39211822; 4477633 JF - 46th Annual Meeting of the American Society for Cell Biology AU - Hwang, K AU - Mahmoodian, F AU - Gruschus, J AU - Ferretti, J AU - Korn, E D AU - Brzeska, H Y1 - 2006/12/09/ PY - 2006 DA - 2006 Dec 09 KW - Myosin KW - Phosphatidylinositol KW - Phosphatidylserine KW - Acanthamoeba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39211822?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.atitle=Acanthamoeba+Myosin+IC+has+Equal+Affinity+for+Phosphatidylserine+and+Phosphatidylinositol+Bisphosphate&rft.au=Hwang%2C+K%3BMahmoodian%2C+F%3BGruschus%2C+J%3BFerretti%2C+J%3BKorn%2C+E+D%3BBrzeska%2C+H&rft.aulast=Hwang&rft.aufirst=K&rft.date=2006-12-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Meeting+of+the+American+Society+for+Cell+Biology&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B0C1CA8A7%2D4052%2D4C63% 2D8057%2D193FDAECCB64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes. AN - 68238859; 17157259 AB - Using a yeast two-hybrid screen, we found that SNIP1 (Smad nuclear-interacting protein 1) associates with c-Myc, a key regulator of cell proliferation and transformation. We demonstrate that SNIP1 functions as an important regulator of c-Myc activity, binding the N terminus of c-Myc through its own C terminus, and that SNIP1 enhances the transcriptional activity of c-Myc both by stabilizing it against proteosomal degradation and by bridging the c-Myc/p300 complex. These effects of SNIP1 on c-Myc likely contribute to synergistic effects of SNIP1, c-Myc, and H-Ras in inducing formation of foci in an in vitro transformation assay and also in supporting anchorage-independent growth. The significant association of SNIP1 and c-Myc staining in a non-small cell lung cancer tissue array is further evidence that their activities might be linked and suggests that SNIP1 might be an important modulator of c-Myc activity in carcinogenesis. JF - Molecular cell AU - Fujii, Makiko AU - Lyakh, Lyudmila A AU - Bracken, Cameron P AU - Fukuoka, Junya AU - Hayakawa, Morisada AU - Tsukiyama, Tadasuke AU - Soll, Steven J AU - Harris, Melissa AU - Rocha, Sonia AU - Roche, Kevin C AU - Tominaga, Shin-ichi AU - Jen, Jin AU - Perkins, Neil D AU - Lechleider, Robert J AU - Roberts, Anita B AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA. Y1 - 2006/12/08/ PY - 2006 DA - 2006 Dec 08 SP - 771 EP - 783 VL - 24 IS - 5 SN - 1097-2765, 1097-2765 KW - Intracellular Signaling Peptides and Proteins KW - 0 KW - Proto-Oncogene Proteins c-myc KW - RNA, Small Interfering KW - S-Phase Kinase-Associated Proteins KW - SNIP1 protein, human KW - Index Medicus KW - Sensitivity and Specificity KW - Tissue Array Analysis KW - Cells, Cultured KW - S-Phase Kinase-Associated Proteins -- metabolism KW - Humans KW - Two-Hybrid System Techniques KW - Chromatin Immunoprecipitation KW - Reverse Transcriptase Polymerase Chain Reaction KW - RNA, Small Interfering -- metabolism KW - Immunohistochemistry KW - Cell Line KW - Intracellular Signaling Peptides and Proteins -- genetics KW - Intracellular Signaling Peptides and Proteins -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - Transcription, Genetic KW - Promoter Regions, Genetic -- genetics KW - Proto-Oncogene Proteins c-myc -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68238859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cell&rft.atitle=SNIP1+is+a+candidate+modifier+of+the+transcriptional+activity+of+c-Myc+on+E+box-dependent+target+genes.&rft.au=Fujii%2C+Makiko%3BLyakh%2C+Lyudmila+A%3BBracken%2C+Cameron+P%3BFukuoka%2C+Junya%3BHayakawa%2C+Morisada%3BTsukiyama%2C+Tadasuke%3BSoll%2C+Steven+J%3BHarris%2C+Melissa%3BRocha%2C+Sonia%3BRoche%2C+Kevin+C%3BTominaga%2C+Shin-ichi%3BJen%2C+Jin%3BPerkins%2C+Neil+D%3BLechleider%2C+Robert+J%3BRoberts%2C+Anita+B&rft.aulast=Fujii&rft.aufirst=Makiko&rft.date=2006-12-08&rft.volume=24&rft.issue=5&rft.spage=771&rft.isbn=&rft.btitle=&rft.title=Molecular+cell&rft.issn=10972765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Mol Cell. 2006 Dec 28;24(6):811-2 [17189184] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export. AN - 68213397; 17043357 AB - The retinoblastoma (RB) tumor suppressor protein is a negative regulator of cell proliferation that is functionally inactivated in the majority of human tumors. Elevated Cdk activity via RB pathway mutations is observed in virtually every human cancer. Thus, Cdk inhibitors have tremendous promise as anticancer agents although detailed mechanistic knowledge of their effects on RB function is needed to harness their full potential. Here, we illustrate a novel function for Cdks in regulating the subcellular localization of RB. We present evidence of significant cytoplasmic mislocalization of ordinarily nuclear RB in cells harboring Cdk4 mutations. Our findings uncover a novel mechanism to circumvent RB-mediated growth suppression by altered nucleocytoplasmic trafficking via the Exportin1 pathway. Cytoplasmically mislocalized RB could be efficiently confined to the nucleus by inhibiting the Exportin1 pathway, reducing Cdk activity, or mutating the Cdk-dependent phosphorylation sites in RB that result in loss of RB-Exportin1 association. Thus RB-mediated tumor suppression can be subverted by phosphorylation-dependent enhancement of nuclear export. These results support the notion that tumor cells can modulate the protein transport machinery thereby making the protein transport process a viable therapeutic target. JF - The Journal of biological chemistry AU - Jiao, Wan AU - Datta, Jashodeep AU - Lin, Huei-Min AU - Dundr, Miroslav AU - Rane, Sushil G AD - Cell Cycle and Human Diseases Group, Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/12/08/ PY - 2006 DA - 2006 Dec 08 SP - 38098 EP - 38108 VL - 281 IS - 49 SN - 0021-9258, 0021-9258 KW - DNA Primers KW - 0 KW - Karyopherins KW - Receptors, Cytoplasmic and Nuclear KW - Recombinant Fusion Proteins KW - Retinoblastoma Protein KW - exportin 1 protein KW - CDK4 protein, human KW - EC 2.7.11.22 KW - Cdk4 protein, mouse KW - Cyclin-Dependent Kinase 4 KW - Index Medicus KW - Active Transport, Cell Nucleus KW - Animals KW - Karyopherins -- metabolism KW - DNA Primers -- genetics KW - Humans KW - Mice KW - Models, Biological KW - Recombinant Fusion Proteins -- chemistry KW - Recombinant Fusion Proteins -- metabolism KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Phosphorylation KW - Cells, Cultured KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Recombinant Fusion Proteins -- genetics KW - Cell Cycle KW - Cell Line KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Retinoblastoma Protein -- chemistry KW - Retinoblastoma Protein -- metabolism KW - Cyclin-Dependent Kinase 4 -- genetics KW - Retinoblastoma Protein -- genetics KW - Cyclin-Dependent Kinase 4 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68213397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Nucleocytoplasmic+shuttling+of+the+retinoblastoma+tumor+suppressor+protein+via+Cdk+phosphorylation-dependent+nuclear+export.&rft.au=Jiao%2C+Wan%3BDatta%2C+Jashodeep%3BLin%2C+Huei-Min%3BDundr%2C+Miroslav%3BRane%2C+Sushil+G&rft.aulast=Jiao&rft.aufirst=Wan&rft.date=2006-12-08&rft.volume=281&rft.issue=49&rft.spage=38098&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-25 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A Three-dimensional Model of Human Organic Anion Transporter 1: AROMATIC AMINO ACIDS REQUIRED FOR SUBSTRATE TRANSPORT AN - 19790906; 7208087 AB - Organic anion transporters (OATs) play a critical role in the handling of endogenous and exogenous organic anions by excretory and barrier tissues. Little is known about the OAT three-dimensional structure or substrate/protein interactions involved in transport. In this investigation, a theoretical three-dimensional model was generated for human OAT1 (hOAT1) based on fold recognition to the crystal structure of the glycerol 3-phosphate transporter (GlpT) from Escherichia coli. GlpT and hOAT1 share several sequence motifs as major facilitator superfamily members. The structural hOAT1 model shows that helices 5, 7, 8, 10, and 11 surround an electronegative putative active site ( similar to 830Aa super(3)). The site opens to the cytoplasm and is surrounded by three residues not previously examined for function (Tyr super(230) (domain 5) and Lys super(431) and Phe super(438) (domain 10)). Effects of these residues on p-aminohippurate (PAH) and cidofovir transport were assessed by point mutations in a Xenopus oocyte expression system. Membrane protein expression was severely limited for the Y230A mutant. For the K431A and F438A mutants, [ super(3)H]PAH uptake was less than 30% of wild-type hOAT1 uptake after protein expression correction. Reduced V sub(max) values for the F438A mutant confirmed lower protein expression. In addition, the F438A mutant exhibited an increased affinity for cidofovir but was not significantly different for PAH. Differences in handling of PAH and cidofovir were also observed for the Y230F mutant. Little uptake was determined for cidofovir, whereas PAH uptake was similar to wild-type hOAT1. Therefore, the hOAT1 structural model has identified two new residues, Tyr super(230) and Phe super(438), which are important for substrate/protein interactions. JF - Journal of Biological Chemistry AU - Perry, Jennifer L AU - Dembla-Rajpal, Neetu AU - Hall, Laura A AU - Pritchard, John B AD - Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 Y1 - 2006/12/08/ PY - 2006 DA - 2006 Dec 08 SP - 38071 EP - 38079 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 49 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Cidofovir KW - Anions KW - Point mutation KW - Membrane proteins KW - Models KW - Glycerol KW - p-aminohippurate KW - Cytoplasm KW - Escherichia coli KW - Crystal structure KW - Xenopus KW - Oocytes KW - Protein interaction KW - Aromatics KW - J 02420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19790906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Three-dimensional+Model+of+Human+Organic+Anion+Transporter+1%3A+AROMATIC+AMINO+ACIDS+REQUIRED+FOR+SUBSTRATE+TRANSPORT&rft.au=Perry%2C+Jennifer+L%3BDembla-Rajpal%2C+Neetu%3BHall%2C+Laura+A%3BPritchard%2C+John+B&rft.aulast=Perry&rft.aufirst=Jennifer&rft.date=2006-12-08&rft.volume=281&rft.issue=49&rft.spage=38071&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-04-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Cidofovir; Glycerol; Anions; Cytoplasm; p-aminohippurate; Point mutation; Crystal structure; Oocytes; Membrane proteins; Aromatics; Protein interaction; Models; Escherichia coli; Xenopus ER - TY - JOUR T1 - Identification of a Lipase-linked Cell Membrane Receptor for Pigment Epithelium-derived Factor AN - 19521909; 7208083 AB - Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of retina, retinoblastoma, and CNS cells. This study was designed to reveal a receptor involved in the biological activities of PEDF. Using a yeast two-hybrid screening, we identified a novel gene from pigment epithelium of the human retina that codes for a PEDF-binding partner, which we term PEDF-R. The derived polypeptide has putative transmembrane, intracellular and extracellular regions, and a phospholipase domain. Recently, PEDF-R (TTS-2.2/independent phospholipase A sub(2) (PLA sub(2)) zeta and mouse desnutrin/ATGL) has been described in adipose cells as a member of the new calcium-independent PLA sub(2)/nutrin/patatin-like phospholipase domain-containing 2 (PNPLA2) family that possesses triglyceride lipase and acylglycerol transacylase activities. Here we describe the PEDF-R gene expression in the retina and its heterologous expression by bacterial and eukaryotic systems, and we demonstrate that its protein product has specific and high binding affinity for PEDF, has a potent phospholipase A sub(2) activity that liberates fatty acids, and is associated with eukaryotic cell membranes. Most importantly, PEDF binding stimulates the enzymatic phospholipase A sub(2) activity of PEDF-R. In conclusion, we have identified a novel PEDF-R gene in the retina for a phospholipase-linked membrane protein with high affinity for PEDF, suggesting a molecular pathway by which ligand/receptor interaction on the cell surface could generate a cellular signal. JF - Journal of Biological Chemistry AU - Notari, Luigi AU - Baladron, Victoriano AU - Aroca-Aguilar, JDaniel AU - Balko, Natalia AU - Heredia, Raul AU - Meyer, Christina AU - Notario, Patricia M AU - Saravanamuthu, Senthil AU - Nueda, Maria-Luisa AU - Sanchez-Sanchez, Francisco AU - Escribano, Julio AU - Laborda, Jorge AU - Becerra, SPatricia AD - National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, the Food and Drug Administration, Bethesda, Maryland 20892, School of Medicine/Centro Regional de Investigaciones Biomedicas, University of Castilla-La Mancha, Albacete 02071, Spain, and Georgetown University, Washington, D. C. 20057 Y1 - 2006/12/08/ PY - 2006 DA - 2006 Dec 08 SP - 38022 EP - 38037 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 49 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Central nervous system KW - Cell surface KW - Retina KW - Phospholipase A2 KW - phospholipase KW - Membrane proteins KW - retinoblastoma KW - Gene expression KW - Triacylglycerol lipase KW - pigment epithelium-derived factor KW - Cell membranes KW - Plasma membranes KW - Triglycerides KW - Pigments KW - Fatty acids KW - Epithelium KW - acylglycerols KW - Neuronal-glial interactions KW - serpins KW - J 02310:Genetics & Taxonomy KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Identification+of+a+Lipase-linked+Cell+Membrane+Receptor+for+Pigment+Epithelium-derived+Factor&rft.au=Notari%2C+Luigi%3BBaladron%2C+Victoriano%3BAroca-Aguilar%2C+JDaniel%3BBalko%2C+Natalia%3BHeredia%2C+Raul%3BMeyer%2C+Christina%3BNotario%2C+Patricia+M%3BSaravanamuthu%2C+Senthil%3BNueda%2C+Maria-Luisa%3BSanchez-Sanchez%2C+Francisco%3BEscribano%2C+Julio%3BLaborda%2C+Jorge%3BBecerra%2C+SPatricia&rft.aulast=Notari&rft.aufirst=Luigi&rft.date=2006-12-08&rft.volume=281&rft.issue=49&rft.spage=38022&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Central nervous system; Retina; Phospholipase A2; phospholipase; Membrane proteins; retinoblastoma; Gene expression; Triacylglycerol lipase; pigment epithelium-derived factor; Cell membranes; Plasma membranes; Pigments; Triglycerides; Fatty acids; Epithelium; acylglycerols; Neuronal-glial interactions; serpins ER - TY - JOUR T1 - Serine-phosphorylated STAT1 is a prosurvival factor in Wilms' tumor pathogenesis. AN - 68228572; 16799645 AB - Wilms' tumor (WT), one of the most common pediatric solid cancers, arises in the developing kidney as a result of genetic and epigenetic changes that lead to the abnormal proliferation and differentiation of the metanephric blastema. As activation of signal transducers and activators of transcription (STATs) plays an important role in the maintenance/growth and differentiation of the metanephric blastema, and constitutively activated STATs facilitate neoplastic behaviors of a variety of cancers, we hypothesized that dysregulation of STAT signaling may also contribute to WT pathogenesis. Accordingly, we evaluated STAT phosphorylation patterns in tumors and found that STAT1 was constitutively phosphorylated on serine 727 (S727) in 19 of 21 primary WT samples and two WT cell lines. An inactivating mutation of S727 to alanine reduced colony formation of WT cells in soft agar by more than 80% and induced apoptosis under conditions of growth stress. S727-phosphorylated STAT1 provided apoptotic resistance for WT cells via upregulation of expression of the heat-shock protein (HSP)27 and antiapoptotic protein myeloid cell leukemia (MCL)-1. The kinase responsible for STAT1 S727 phosphorylation in WT cells was identified based upon the use of selective inhibitors as protein kinase CK2, not p38, MAP-kinase kinase (MEK)1/2, phosphatidylinositol 3'-kinase, protein kinase C or Ca/calmodulin-dependent protein kinase II (CaMKII). The inhibition of CK2 blocked the anchorage-independent growth of WT cells and induced apoptosis under conditions of growth stress. Our findings suggest that serine-phosphorylated STAT1, as a downstream target of protein kinase CK2, plays a critical role in the pathogenesis of WT and possibly other neoplasms with similar STAT1 phosphorylation patterns. JF - Oncogene AU - Timofeeva, O A AU - Plisov, S AU - Evseev, A A AU - Peng, S AU - Jose-Kampfner, M AU - Lovvorn, H N AU - Dome, J S AU - Perantoni, A O AD - Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2006/12/07/ PY - 2006 DA - 2006 Dec 07 SP - 7555 EP - 7564 VL - 25 IS - 58 SN - 0950-9232, 0950-9232 KW - Apoptosis Regulatory Proteins KW - 0 KW - HSP27 Heat-Shock Proteins KW - HSPB1 protein, human KW - Heat-Shock Proteins KW - Myeloid Cell Leukemia Sequence 1 Protein KW - Neoplasm Proteins KW - Proto-Oncogene Proteins c-bcl-2 KW - STAT1 Transcription Factor KW - STAT1 protein, human KW - enhanced green fluorescent protein KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Phosphoserine KW - 17885-08-4 KW - Casein Kinase II KW - EC 2.7.11.1 KW - Index Medicus KW - Casein Kinase II -- metabolism KW - Heat-Shock Proteins -- metabolism KW - Kidney -- pathology KW - Humans KW - Cell Line, Tumor KW - Child KW - Phosphoserine -- metabolism KW - Green Fluorescent Proteins -- genetics KW - Phosphorylation KW - Transfection KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis Regulatory Proteins -- metabolism KW - Neoplasm Proteins -- metabolism KW - Cell Line KW - Kidney Neoplasms -- pathology KW - Wilms Tumor -- metabolism KW - Kidney Neoplasms -- metabolism KW - Wilms Tumor -- pathology KW - STAT1 Transcription Factor -- metabolism KW - Cell Survival UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68228572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Serine-phosphorylated+STAT1+is+a+prosurvival+factor+in+Wilms%27+tumor+pathogenesis.&rft.au=Timofeeva%2C+O+A%3BPlisov%2C+S%3BEvseev%2C+A+A%3BPeng%2C+S%3BJose-Kampfner%2C+M%3BLovvorn%2C+H+N%3BDome%2C+J+S%3BPerantoni%2C+A+O&rft.aulast=Timofeeva&rft.aufirst=O&rft.date=2006-12-07&rft.volume=25&rft.issue=58&rft.spage=7555&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peginterferon and ribavirin for chronic hepatitis C. AN - 68225354; 17151366 JF - The New England journal of medicine AU - Hoofnagle, Jay H AU - Seeff, Leonard B AD - Liver Disease Research Branch, Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA. hoofnaglej@extra.niddk.nih.gov Y1 - 2006/12/07/ PY - 2006 DA - 2006 Dec 07 SP - 2444 EP - 2451 VL - 355 IS - 23 KW - Antiviral Agents KW - 0 KW - Interferon-alpha KW - RNA, Viral KW - Recombinant Proteins KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - interferon alfa-2a KW - 47RRR83SK7 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2b KW - G8RGG88B68 KW - peginterferon alfa-2a KW - Q46947FE7K KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Humans KW - Adult KW - Practice Guidelines as Topic KW - Female KW - RNA, Viral -- blood KW - Antiviral Agents -- therapeutic use KW - Interferon-alpha -- pharmacology KW - Ribavirin -- therapeutic use KW - Interferon-alpha -- therapeutic use KW - Polyethylene Glycols -- therapeutic use KW - Hepacivirus -- isolation & purification KW - Hepatitis C, Chronic -- drug therapy KW - Antiviral Agents -- economics KW - Polyethylene Glycols -- adverse effects KW - Polyethylene Glycols -- pharmacology KW - Ribavirin -- adverse effects KW - Interferon-alpha -- adverse effects KW - Antiviral Agents -- pharmacology KW - Antiviral Agents -- adverse effects KW - Hepacivirus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68225354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Peginterferon+and+ribavirin+for+chronic+hepatitis+C.&rft.au=Hoofnagle%2C+Jay+H%3BSeeff%2C+Leonard+B&rft.aulast=Hoofnagle&rft.aufirst=Jay&rft.date=2006-12-07&rft.volume=355&rft.issue=23&rft.spage=2444&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-13 N1 - Date created - 2006-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2007 Mar 22;356(12):1269; author reply 1271 [17377169] N Engl J Med. 2007 Mar 22;356(12):1270; author reply 1271 [17380578] N Engl J Med. 2007 Mar 22;356(12):1270-1; author reply 1271 [17378100] N Engl J Med. 2007 Mar 22;356(12):1269; author reply 1271 [17380576] N Engl J Med. 2007 Mar 22;356(12):1269-70; author reply 1271 [17380575] N Engl J Med. 2007 Mar 22;356(12):1270; author reply 1271 [17380577] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Biotech Solutions for Genetic Diseases: Molecular Diagnostics T2 - 33rd Annual Convention of the Philippine Society for Biochemistry and Molecular Biology (PSBMB 2007) AN - 39329078; 4508472 JF - 33rd Annual Convention of the Philippine Society for Biochemistry and Molecular Biology (PSBMB 2007) AU - Eva Maria C. Cutiongco-de laPaz Y1 - 2006/12/07/ PY - 2006 DA - 2006 Dec 07 KW - Biotechnology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39329078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=33rd+Annual+Convention+of+the+Philippine+Society+for+Biochemistry+and+Molecular+Biology+%28PSBMB+2007%29&rft.atitle=Biotech+Solutions+for+Genetic+Diseases%3A+Molecular+Diagnostics&rft.au=Eva+Maria+C.+Cutiongco-de+laPaz&rft.aulast=Eva+Maria+C.+Cutiongco-de+laPaz&rft.aufirst=&rft.date=2006-12-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=33rd+Annual+Convention+of+the+Philippine+Society+for+Biochemistry+and+Molecular+Biology+%28PSBMB+2007%29&rft.issn=&rft_id=info:doi/ L2 - http://www.psbmb.org/33rdannualconvention.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Perinatal factors, growth and development, and osteosarcoma risk AN - 954575827; 13759403 AB - Osteosarcoma incidence patterns suggest an aetiologic role for perinatal factors, and growth and development. Osteosarcoma patients (n=158) and controls with benign orthopaedic conditions (n=141) under age 40 were recruited from US orthopaedic surgery departments. Exposures were ascertained by interview, birth, and growth records. Age- and sex-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated. Current height and age- and sex-specific height percentiles were not associated with osteosarcoma risk. Male cases, however, appeared to have an earlier adolescent growth period, and earlier attainment of final height (OR=7.1; 95% CI=1.6-50 for <19 vs 19+ years), whereas earlier puberty appeared protective with ORs of 0.41 (95% CI 0.18-0.89) and 0.68 (95% CI 0.31-1.5) for developing facial and pubic hair, respectively. High birth weight was associated with an elevated osteosarcoma risk (OR=3.9; CI=1.7-10 for 4000g vs 3000-3500g), although there was no trend in risk with increasing weight. These data provide some evidence that osteosarcoma is related to size at birth and in early adolescence, while earlier puberty in male subjects may be protective.British Journal of Cancer (2006) 95, 1603-1607. doi:10.1038/sj.bjc.6603474 www.bjcancer.com Published online 14 November 2006 JF - British Journal of Cancer AU - Troisi, R AU - Masters, M N AU - Joshipura, K AU - Douglass, C AU - Cole, B F AU - Hoover, R N AD - [1] 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA [2] 2 Department of Community and Family Medicine, Dartmouth Medical School, Hanover, NH, USA Y1 - 2006/12/04/ PY - 2006 DA - 2006 Dec 04 SP - 1603 EP - 1607 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 95 IS - 11 SN - 0007-0920, 0007-0920 KW - Calcium & Calcified Tissue Abstracts; Risk Abstracts KW - Birth weight KW - Age KW - Body height KW - Bone growth KW - Development KW - surgery KW - Growth KW - Surgery KW - birth weight KW - Adolescents KW - Benign KW - Data processing KW - Adolescence KW - Osteosarcoma KW - Hair KW - Cancer KW - Internet KW - Puberty KW - R2 23060:Medical and environmental health KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954575827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Perinatal+factors%2C+growth+and+development%2C+and+osteosarcoma+risk&rft.au=Troisi%2C+R%3BMasters%2C+M+N%3BJoshipura%2C+K%3BDouglass%2C+C%3BCole%2C+B+F%3BHoover%2C+R+N&rft.aulast=Troisi&rft.aufirst=R&rft.date=2006-12-04&rft.volume=95&rft.issue=11&rft.spage=1603&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603474 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - Birth weight; Age; Data processing; Body height; Adolescence; Bone growth; Osteosarcoma; Development; Hair; Cancer; Surgery; Internet; Puberty; Benign; Growth; birth weight; surgery; Adolescents DO - http://dx.doi.org/10.1038/sj.bjc.6603474 ER - TY - CPAPER T1 - Effects of Early Experience and Lack of Social Support on the Endocrine and Behavioral Responses of Rhesus Macaques (Macaca mulatta) to Separation Stress T2 - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AN - 40472719; 4487153 JF - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AU - Schwandt, Melanie L AU - Erickson, Kristine AU - Barr, Christina S AU - Lindell, Stephen G AU - Suomi, Stephen J AU - Dee Higley, James Y1 - 2006/12/03/ PY - 2006 DA - 2006 Dec 03 KW - Stress KW - Early experience KW - Endocrinology KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40472719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.atitle=Effects+of+Early+Experience+and+Lack+of+Social+Support+on+the+Endocrine+and+Behavioral+Responses+of+Rhesus+Macaques+%28Macaca+mulatta%29+to+Separation+Stress&rft.au=Schwandt%2C+Melanie+L%3BErickson%2C+Kristine%3BBarr%2C+Christina+S%3BLindell%2C+Stephen+G%3BSuomi%2C+Stephen+J%3BDee+Higley%2C+James&rft.aulast=Schwandt&rft.aufirst=Melanie&rft.date=2006-12-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/Docs/2006%20Program%20Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Variation at the Rat CRH-R1 Locus and Sensitivity to Relapse into Alcohol Seeking Induced by Environmental Stress T2 - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AN - 40472345; 4487148 JF - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AU - Hansson, Anita Christiane AU - Cippitelli, Andrea AU - Sommer, Wolfgang H AU - Fedeli, Amalia AU - Bjork, Karl AU - Soverchia, Laura AU - Terasmaa, Anton AU - Massi, Maurizio AU - Markus, Heilig] AU - Ciccocioppo, Roberto Y1 - 2006/12/03/ PY - 2006 DA - 2006 Dec 03 KW - Alcohols KW - Environmental stress KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40472345?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.atitle=Variation+at+the+Rat+CRH-R1+Locus+and+Sensitivity+to+Relapse+into+Alcohol+Seeking+Induced+by+Environmental+Stress&rft.au=Hansson%2C+Anita+Christiane%3BCippitelli%2C+Andrea%3BSommer%2C+Wolfgang+H%3BFedeli%2C+Amalia%3BBjork%2C+Karl%3BSoverchia%2C+Laura%3BTerasmaa%2C+Anton%3BMassi%2C+Maurizio%3BMarkus%2C+Heilig%5D%3BCiccocioppo%2C+Roberto&rft.aulast=Hansson&rft.aufirst=Anita&rft.date=2006-12-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/Docs/2006%20Program%20Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Connectivity in Children with Bipolar Disorder: Impairment in the Face Emotion Processing Circuit T2 - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AN - 40471908; 4487158 JF - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AU - Rich, Brendan A AU - Berghorst, Lisa AU - Fromm, Stephen AU - Dickstein, Daniel AU - Brotman, Melissa AU - Pine, Daniel AU - Leibenluft, Ellen Y1 - 2006/12/03/ PY - 2006 DA - 2006 Dec 03 KW - Children KW - Pattern recognition KW - Circuits KW - Face KW - Emotions KW - Bipolar disorder KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40471908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.atitle=Neural+Connectivity+in+Children+with+Bipolar+Disorder%3A+Impairment+in+the+Face+Emotion+Processing+Circuit&rft.au=Rich%2C+Brendan+A%3BBerghorst%2C+Lisa%3BFromm%2C+Stephen%3BDickstein%2C+Daniel%3BBrotman%2C+Melissa%3BPine%2C+Daniel%3BLeibenluft%2C+Ellen&rft.aulast=Rich&rft.aufirst=Brendan&rft.date=2006-12-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/Docs/2006%20Program%20Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association of a Functional Variant in the Mu-Opioid Receptor Gene (OPRM1 C77g) with Attachment Behavior in Infant Rhesus Macaques T2 - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AN - 40471841; 4487147 JF - 45th Annual Meeting of the American College of Neuropsychopharmacology (ACNP 2006) AU - Barr, Christina S AU - Schwandt, Melanie L AU - Lindell, Stephen G AU - Maestripieri, Dario AU - Goldman, David AU - Suomi, Stephen J AU - Higley, J Dee AU - Heilig, Markus Y1 - 2006/12/03/ PY - 2006 DA - 2006 Dec 03 KW - Infants KW - Opioid receptors (type mu) KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40471841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.atitle=Association+of+a+Functional+Variant+in+the+Mu-Opioid+Receptor+Gene+%28OPRM1+C77g%29+with+Attachment+Behavior+in+Infant+Rhesus+Macaques&rft.au=Barr%2C+Christina+S%3BSchwandt%2C+Melanie+L%3BLindell%2C+Stephen+G%3BMaestripieri%2C+Dario%3BGoldman%2C+David%3BSuomi%2C+Stephen+J%3BHigley%2C+J+Dee%3BHeilig%2C+Markus&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2006-12-03&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=45th+Annual+Meeting+of+the+American+College+of+Neuropsychopharmacology+%28ACNP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.acnp.org/Docs/2006%20Program%20Book.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The Importance of the Lexicon in Tagging Biological Text AN - 85646114; 200703864 AB - A part-of-speech tagger is a fundamental and indispensable tool in computational linguistics, typically employed at the critical early stages of processing. Although taggers are widely available that achieve high accuracy in very general domains, these do not perform nearly as well when applied to novel specialized domains, and this is especially true with biological text. We present a stochastic tagger that achieves over 97.44% accuracy on MEDLINE abstracts. A primary component of the tagger is its lexicon which enumerates the permitted parts-of-speech for the 10000 words most frequently occurring in MEDLINE. We present evidence for the conclusion that the lexicon is as vital to tagger accuracy as a training corpus, and more important than previously thought. Tables, Figures, References. Adapted from the source document JF - Natural Language Engineering AU - Smith, Lawrence H AU - Rindflesch, Thomas C AU - Wilbur, W John AD - National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD, USA [lsmith@ncbi.nlm.nih.gov] Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 335 EP - 351 VL - 12 IS - 4 SN - 1351-3249, 1351-3249 KW - Tagging (Computational Linguistics) (87380) KW - Scientific Technical Language (75350) KW - Form Classes (25250) KW - Lexicon (47150) KW - Electronic Dictionaries (21400) KW - Natural Language Processing (56550) KW - article KW - 5113: descriptive linguistics; computational and mathematical linguistics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85646114?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Natural+Language+Engineering&rft.atitle=The+Importance+of+the+Lexicon+in+Tagging+Biological+Text&rft.au=Smith%2C+Lawrence+H%3BRindflesch%2C+Thomas+C%3BWilbur%2C+W+John&rft.aulast=Smith&rft.aufirst=Lawrence&rft.date=2006-12-01&rft.volume=12&rft.issue=4&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Natural+Language+Engineering&rft.issn=13513249&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2007-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - NLENFE N1 - SubjectsTermNotLitGenreText - Tagging (Computational Linguistics) (87380); Lexicon (47150); Scientific Technical Language (75350); Natural Language Processing (56550); Form Classes (25250); Electronic Dictionaries (21400) ER - TY - JOUR T1 - Characterization of rat spiral ligament cell line immortalized by adenovirus 12-simian virus 40 hybrid virus. AN - 85402878; pmid-17214269 AB - Spiral ligament fibrocytes play an important role in inner ear ion homeostasis and are classified into several subtypes according to expression of specific enzymes such as Na+, K+ -ATPase, Ca++ -ATPase, and carbonic anhydrase. Although our understanding of the cell and molecular biology of spiral ligament fibrocytes has increased over time, access to these cells still remains a significant hurdle hindering future studies. In this study, we aimed to establish a rat spiral ligament cell line with minimal disruption of the original characteristics.The primary spiral ligament fibrocytes were exposed to adenovirus 12-simian virus 40 hybrid virus for immortalization. Karyotypic analysis was performed after stabilization of the infected cells, and the population doubling time was compared to that of the primary cell. The cell line was characterized by immunolabeling and electron microscopy.We describe the establishment and characterization of a line of type I spiral ligament fibrocytes immortalized with an adenovirus 12-simian virus 40 hybrid virus.This cell line can be a useful research tool for investigating the role of spiral ligament fibrocytes in homeostasis and inflammation of the inner ear. JF - The Annals of otology, rhinology, and laryngology AU - Yian, Christopher AU - Moon, Sung K AU - Jin, Sunji AU - Webster, Paul AU - Rhim, Johng S AU - Andalibi, Ali AU - Lim, David J AD - Laboratory of Cell Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, USA. Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 930 EP - 938 VL - 115 IS - 12 SN - 0003-4894, 0003-4894 KW - National Library of Medicine KW - *Adenoviridae: genetics KW - Animals KW - Cell Culture Techniques KW - Cell Line KW - Cell Transformation, Viral KW - *Cochlea: cytology KW - Connexins: metabolism KW - Fluorescent Antibody Technique, Indirect KW - Hybridization, Genetic KW - Rats KW - Rats, Inbred WKY KW - *Simian virus 40: genetics KW - Vimentin: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.atitle=Characterization+of+rat+spiral+ligament+cell+line+immortalized+by+adenovirus+12-simian+virus+40+hybrid+virus.&rft.au=Yian%2C+Christopher%3BMoon%2C+Sung+K%3BJin%2C+Sunji%3BWebster%2C+Paul%3BRhim%2C+Johng+S%3BAndalibi%2C+Ali%3BLim%2C+David+J&rft.aulast=Yian&rft.aufirst=Christopher&rft.date=2006-12-01&rft.volume=115&rft.issue=12&rft.spage=930&rft.isbn=&rft.btitle=&rft.title=The+Annals+of+otology%2C+rhinology%2C+and+laryngology&rft.issn=00034894&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Biotinylated biphenyl ketone-containing 2,4-dioxobutanoic acids designed as HIV-1 integrase photoaffinity ligands. AN - 68975711; 16908168 AB - The diketo acid (DKA) class of HIV-1 integrase inhibitors are thought to function by chelating divalent metal ions within the enzyme catalytic center. However, differences in mutations conferring resistance among sub-families of DKA inhibitors suggest that multiple binding orientations may exist. In order to facilitate identification of DKA-binding sites, biotin-tagged biphenyl ketone-containing 2,4-dioxobutanoic acids were prepared as DKA photoaffinity probes. Introduction of biotin was obtained by means of Huisgen [3+2] cycloaddition 'click chemistry.' Two photoprobes, 5a and 5b, were prepared bearing short and long linker segments, respectively, between the biotin and DKA nucleus. The greatest inhibitory potency was shown by 5b, which inhibited 3'-processing and strand transfer reactions with IC50 values of > 333 microM and 12.4 microM, respectively. In cross-linking assays designed to measure disruption of substrate DNA binding, the photoprobes behaved similarly to a reference DKA inhibitor. Analogues 5a and 5b represent novel photoaffinity ligands, which may be useful in clarifying the HIV-1 binding interactions of DKA inhibitors. JF - Bioorganic & medicinal chemistry AU - Zhao, Xue Zhi AU - Semenova, Elena A AU - Liao, Chenzhong AU - Nicklaus, Marc AU - Pommier, Yves AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, CCR, NCI, NIH, Frederick, MD 21702, USA. Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 7816 EP - 7825 VL - 14 IS - 23 SN - 0968-0896, 0968-0896 KW - Acetoacetates KW - 0 KW - Anti-HIV Agents KW - Biphenyl Compounds KW - Cross-Linking Reagents KW - HIV Integrase Inhibitors KW - Ligands KW - Photoaffinity Labels KW - acetoacetic acid KW - 4ZI204Y1MC KW - HIV Integrase KW - EC 2.7.7.- KW - Index Medicus KW - Acetoacetates -- pharmacology KW - Acetoacetates -- metabolism KW - Humans KW - Inhibitory Concentration 50 KW - Drug Design KW - Acetoacetates -- chemical synthesis KW - Biotinylation KW - Structure-Activity Relationship KW - Binding Sites KW - Anti-HIV Agents -- chemistry KW - Biphenyl Compounds -- chemical synthesis KW - Photoaffinity Labels -- chemistry KW - HIV Integrase Inhibitors -- chemistry KW - Anti-HIV Agents -- pharmacology KW - HIV Integrase Inhibitors -- pharmacology KW - Biphenyl Compounds -- pharmacology KW - HIV Integrase -- chemistry KW - Biphenyl Compounds -- metabolism KW - HIV Integrase Inhibitors -- metabolism KW - HIV Integrase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68975711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+%26+medicinal+chemistry&rft.atitle=Biotinylated+biphenyl+ketone-containing+2%2C4-dioxobutanoic+acids+designed+as+HIV-1+integrase+photoaffinity+ligands.&rft.au=Zhao%2C+Xue+Zhi%3BSemenova%2C+Elena+A%3BLiao%2C+Chenzhong%3BNicklaus%2C+Marc%3BPommier%2C+Yves%3BBurke%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2006-12-01&rft.volume=14&rft.issue=23&rft.spage=7816&rft.isbn=&rft.btitle=&rft.title=Bioorganic+%26+medicinal+chemistry&rft.issn=09680896&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-30 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Miltefosine: issues to be addressed in the future. AN - 68947414; 16750231 AB - Future issues that need to be addressed for miltefosine are efficacy against non-Indian visceral leishmaniasis, efficacy in HIV-coinfected patients, efficacy against the many forms of cutaneous and mucosal disease, effectiveness under clinical practice conditions, generation of drug resistance and the need to provide a second antileishmanial agent to protect against this disastrous event, and the ability to maintain reproductive contraceptive practices under routine clinical conditions. JF - Transactions of the Royal Society of Tropical Medicine and Hygiene AU - Berman, J AU - Bryceson, A D M AU - Croft, S AU - Engel, J AU - Gutteridge, W AU - Karbwang, J AU - Sindermann, H AU - Soto, J AU - Sundar, S AU - Urbina, J A AD - bermanjo@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - S41 EP - S44 VL - 100 Suppl 1 SN - 0035-9203, 0035-9203 KW - Antiprotozoal Agents KW - 0 KW - Phosphorylcholine KW - 107-73-3 KW - miltefosine KW - 53EY29W7EC KW - Index Medicus KW - HIV Infections -- complications KW - Pregnancy Complications, Parasitic -- drug therapy KW - Humans KW - Drug Resistance KW - Forecasting KW - Abnormalities, Drug-Induced -- prevention & control KW - Female KW - Pregnancy KW - Phosphorylcholine -- therapeutic use KW - Leishmaniasis -- complications KW - Leishmaniasis -- drug therapy KW - Antiprotozoal Agents -- therapeutic use KW - Phosphorylcholine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68947414?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Transactions+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Miltefosine%3A+issues+to+be+addressed+in+the+future.&rft.au=Berman%2C+J%3BBryceson%2C+A+D+M%3BCroft%2C+S%3BEngel%2C+J%3BGutteridge%2C+W%3BKarbwang%2C+J%3BSindermann%2C+H%3BSoto%2C+J%3BSundar%2C+S%3BUrbina%2C+J+A&rft.aulast=Berman&rft.aufirst=J&rft.date=2006-12-01&rft.volume=100+Suppl+1&rft.issue=&rft.spage=S41&rft.isbn=&rft.btitle=&rft.title=Transactions+of+the+Royal+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=00359203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-22 N1 - Date created - 2006-10-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2. AN - 68824727; 16808938 AB - Hepatogenous photosensitization occurs in livestock following damage to the liver or biliary apparatus that results in impaired excretion of phytoporphyrin (phylloerythrin), a photosensitizer. Based on earlier observations that porphyrin-based photosensitizers are substrates of the ATP-binding cassette transporter ABCG2, we examined the ability of the hepatic transporters ABCB1 (P-glycoprotein) and ABCG2 to transport phytoporphyrin. Transport of phytoporphyrin was blocked by the ABCG2-specific inhibitor fumitremorgin C (FTC) in human embryonic kidney cells transfected with full length human ABCG2, while no transport by cells transfected with human ABCB1 was noted. FTC-inhibited transport of phytoporphyrin was also demonstrated in ABCG2-expressing LLC-PK1 pig kidney cells, consistent with the idea that the pig orthologue, like human ABCG2, transports the photosensitizer. ABCG2 expression was confirmed by immunohistochemistry in the hepatocytes of cow, pig and sheep livers. We conclude that phytoporphyrin is a substrate for ABCG2 and that the transporter is likely responsible for its biliary excretion. JF - Research in veterinary science AU - Robey, Robert W AU - Fetsch, Patricia A AU - Polgar, Orsolya AU - Dean, Michael AU - Bates, Susan E AD - Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. robeyr@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 345 EP - 349 VL - 81 IS - 3 SN - 0034-5288, 0034-5288 KW - ABCB1 protein, human KW - 0 KW - ABCG2 protein, human KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Neoplasm Proteins KW - Organic Anion Transporters KW - P-Glycoprotein KW - P-Glycoproteins KW - Chlorophyll KW - 1406-65-1 KW - phytoporphyrin KW - 26359-43-3 KW - Index Medicus KW - Swine KW - Animals KW - Liver -- cytology KW - Pancreas -- cytology KW - Sheep KW - Humans KW - Liver -- metabolism KW - Amino Acid Sequence KW - Cattle KW - Pancreas -- metabolism KW - Molecular Sequence Data KW - Gene Expression Regulation KW - Cell Line KW - Chlorophyll -- adverse effects KW - Chlorophyll -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - ATP-Binding Cassette Transporters -- chemistry KW - Organic Anion Transporters -- metabolism KW - Neoplasm Proteins -- chemistry KW - Neoplasm Proteins -- metabolism KW - Chlorophyll -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68824727?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Research+in+veterinary+science&rft.atitle=The+livestock+photosensitizer%2C+phytoporphyrin+%28phylloerythrin%29%2C+is+a+substrate+of+the+ATP-binding+cassette+transporter+ABCG2.&rft.au=Robey%2C+Robert+W%3BFetsch%2C+Patricia+A%3BPolgar%2C+Orsolya%3BDean%2C+Michael%3BBates%2C+Susan+E&rft.aulast=Robey&rft.aufirst=Robert&rft.date=2006-12-01&rft.volume=81&rft.issue=3&rft.spage=345&rft.isbn=&rft.btitle=&rft.title=Research+in+veterinary+science&rft.issn=00345288&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of cyclins and cyclins inhibitors in the multistep process of HPV-associated cervical carcinoma. AN - 68400606; 18301453 AB - Human papillomavirus (HPV) types 16 and 18 are associated with cervical carcinogenesis. This is possibly achieved through an interaction between HPV oncogenic proteins and some cell cycle regulatory genes. However, the exact pathogenetic mechanisms are not well defined yet. We investigated 110 subjects (43 invasive squamous cell carcinoma (ISCC), 38 CIN III, 11 CIN II, 18 CIN I) confirmed to be positive for HPV16 and/or 18 as well as 20 normal cervical tissue (NCT) samples for abnormal expression of cyclin D1, cyclin E, CDK4, cyclin inhibitors (p21 (waf), p27, p16 (INK4A)) and Ki-67 using immunohistochemistry and differential PCR techniques. There was a significant increase in the expression of Ki-67, cyclin E, CDK4, p16 (INK4A) (p=0.003, 0.001, 0.001) and a significant decrease in p27 (Kip1) from NCT to ISCC (p=0.003). There was a significant correlation between altered expression of p27 (KIP1) and p16(INK4A) (p<0.001), cyclin D1 and CDK4 (p=0.001), cyclin E and p27 (Kip1) (p=0.011) in all studied groups. In ISCC, there was significant relationship between standard clinicopathological prognostic factors and high Ki-67 index , increased cyclin D1 and cyclin E, reduced p27 (Kip1) and p21 (waf). 1) Aberrations involving p27 (KIP1), cyclin E, CDK4 and p16 (INK4A) are considered early events in HPV 16 and 18-associated cervical carcinogenesis (CINI & II), whereas cyclin D1 aberrations are late events (CINIII & ISCC) 2) Immunohistochemical tests for p16 (INK4A) and cyclin E could help in early diagnosis of cervical carcinoma 3) Only FIGO stage, cyclin D1, p27 (Kip1) and Ki-67 are independent prognostic factors that might help in predicting outcome of cervical cancer patients. JF - Journal of the Egyptian National Cancer Institute AU - Bahnassy, Abeer A AU - Zekri, Abdel Rahman N AU - Alam El-Din, Hanaa M AU - Aboubakr, Amany A AU - Kamel, Khaled AU - El-Sabah, Mahmoud T AU - Mokhtar, Nadia M AD - The Departments of Pathology, National Cancer Institute, Cairo, Egypt. chaya2000@hotmail.com Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 292 EP - 302 VL - 18 IS - 4 SN - 1110-0362, 1110-0362 KW - Cyclin E KW - 0 KW - Cyclin-Dependent Kinase Inhibitor Proteins KW - Cyclins KW - Ki-67 Antigen KW - Cyclin-Dependent Kinase Inhibitor p27 KW - 147604-94-2 KW - CDC2 Protein Kinase KW - EC 2.7.11.22 KW - CDK4 protein, human KW - Cyclin-Dependent Kinase 4 KW - Cyclin-Dependent Kinases KW - Index Medicus KW - Cyclin E -- genetics KW - CDC2 Protein Kinase -- genetics KW - CDC2 Protein Kinase -- metabolism KW - Humans KW - Ki-67 Antigen -- metabolism KW - Human papillomavirus 18 KW - Genes, p16 KW - Cyclin-Dependent Kinase Inhibitor p27 -- metabolism KW - Cyclin E -- metabolism KW - Cyclin-Dependent Kinase 4 -- metabolism KW - Cyclin-Dependent Kinase Inhibitor p27 -- genetics KW - Gene Expression Regulation, Neoplastic KW - Genes, bcl-1 KW - Ki-67 Antigen -- genetics KW - Tumor Cells, Cultured KW - Human papillomavirus 16 KW - Cyclin-Dependent Kinase 4 -- genetics KW - Female KW - Cyclin-Dependent Kinases -- metabolism KW - Cyclin-Dependent Kinases -- genetics KW - Carcinoma, Squamous Cell -- enzymology KW - Uterine Cervical Neoplasms -- enzymology KW - Carcinoma, Squamous Cell -- diagnosis KW - Cervical Intraepithelial Neoplasia -- pathology KW - Papillomavirus Infections -- enzymology KW - Cyclin-Dependent Kinases -- physiology KW - Papillomavirus Infections -- complications KW - Uterine Cervical Neoplasms -- diagnosis KW - Papillomavirus Infections -- genetics KW - Cervical Intraepithelial Neoplasia -- enzymology KW - Cyclins -- physiology KW - Cervical Intraepithelial Neoplasia -- genetics KW - Carcinoma, Squamous Cell -- pathology KW - Cyclin-Dependent Kinase Inhibitor Proteins -- metabolism KW - Cyclin-Dependent Kinase Inhibitor Proteins -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Cyclins -- metabolism KW - Uterine Cervical Neoplasms -- genetics KW - Cyclin-Dependent Kinase Inhibitor Proteins -- physiology KW - Cervical Intraepithelial Neoplasia -- diagnosis KW - Uterine Cervical Neoplasms -- pathology KW - Cyclins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68400606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=The+role+of+cyclins+and+cyclins+inhibitors+in+the+multistep+process+of+HPV-associated+cervical+carcinoma.&rft.au=Bahnassy%2C+Abeer+A%3BZekri%2C+Abdel+Rahman+N%3BAlam+El-Din%2C+Hanaa+M%3BAboubakr%2C+Amany+A%3BKamel%2C+Khaled%3BEl-Sabah%2C+Mahmoud+T%3BMokhtar%2C+Nadia+M&rft.aulast=Bahnassy&rft.aufirst=Abeer&rft.date=2006-12-01&rft.volume=18&rft.issue=4&rft.spage=292&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of differentiating agents on interferon-gamma (INF-gamma) level in leukemic cells propagated ex-vivo. AN - 68397490; 18301452 AB - Leukemia is a type of cancer that starts in the bone marrow. The anticancer drugs used in the treatment of patients suffering from the disease have many side effects due to their toxicity. This fact has prompted researchers to search for other agents instead of, or in combination with, these anticancer drugs. Differentiating agents (DAs) including Na-Butyrate (NaBu), trans-retinoic acid (TRA), dibutyryl- cAMP (Bu-cAMP) and many others have been used for this purpose. In this investigation, we studied 120 patients with acute myeloid leukemia (AML),presenting to the Oncology Institute of Tanta, Egypt. We studied the effect of some differentiating agents (DAs)mainly Na-Butyrate (Na-Bu., 1mM), trans-retinoic acid (TRA, l micro M) and dibutyryl-cAMP (Bu-cAMP, lmM) on the morphology of leukemia cells propagated ex-vivo for 3 and 6 days. We also studied the level of interferon- gamma and its release in the conditioned media of the leukemic cells compared to normal leukocytes. The results revealed that DAs enhanced the conversion of the immature granulocytes into mature ones clearly at 6 days of treatment when we used the agents in combination. The results also showed that statistically significant elevation (p<0.001) of interferon- gamma level was found to be in the conditioned media of the treated leukemic cells (3 and 6 days) using the previously mentioned agents alone or in combination; that could reach almost the level in the cultured media of normal leukocytes. In conclusion, this work could highlight the possibility of using DAs as a novel complementary therapy in the management of acute myeloid leukemia (AML) via the activation of the immune surveillance of patients suffering from AML through raising the interferon- gamma level. Further work is recommended to use DAs in clinical trials with and without conventional anticancer drugs for the management of patient with AML. JF - Journal of the Egyptian National Cancer Institute AU - El-Houseini, Motawa E AU - Amer, Iman R AU - Hussein, Tarek D AD - The Department of Cancer Biology NCI, Cairo University. Motawa_matter@yahoo.com Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 283 EP - 291 VL - 18 IS - 4 SN - 1110-0362, 1110-0362 KW - Antineoplastic Agents KW - 0 KW - Butyrates KW - Culture Media, Conditioned KW - Drug Combinations KW - Tretinoin KW - 5688UTC01R KW - Bucladesine KW - 63X7MBT2LQ KW - Interferon-gamma KW - 82115-62-6 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Tumor Cells, Cultured KW - Culture Media, Conditioned -- chemistry KW - Humans KW - Cell Shape -- drug effects KW - Cell Culture Techniques KW - Culture Media, Conditioned -- metabolism KW - Bucladesine -- pharmacology KW - Tretinoin -- pharmacology KW - Leukemia, Myeloid, Acute -- metabolism KW - Butyrates -- pharmacology KW - Interferon-gamma -- metabolism KW - Leukemia, Myeloid, Acute -- pathology KW - Cell Differentiation -- drug effects KW - Interferon-gamma -- analysis KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68397490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Effect+of+differentiating+agents+on+interferon-gamma+%28INF-gamma%29+level+in+leukemic+cells+propagated+ex-vivo.&rft.au=El-Houseini%2C+Motawa+E%3BAmer%2C+Iman+R%3BHussein%2C+Tarek+D&rft.aulast=El-Houseini&rft.aufirst=Motawa&rft.date=2006-12-01&rft.volume=18&rft.issue=4&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-04-09 N1 - Date created - 2008-02-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The importance of usability testing in the development of an internet-based smoking cessation treatment resource. AN - 68351163; 17491175 AB - It has been cogently argued that Web-based interventions hold substantial promise to deliver effective cessation to a wide audience. However, the potential effectiveness of a site is constrained by fundamental issues such as ease of navigation and structure of information, which impact a visitor's ability to find relevant information. Use of content and Web-design experts to assist in the development of cessation sites is a common approach. This approach, although highly useful, may fail to adequately identify problems that a more typical, target user would experience when visiting the site. Formal usability testing provides a user-centric approach to assessing a site's functionality. In this paper, we provide an example of this approach used in the development of a cessation Web site. JF - Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco AU - Stoddard, Jacqueline L AU - Augustson, Erik M AU - Mabry, Patricia L AD - National Cancer Institute, Tobacco Control Research Branch, 6130 Executive Blvd MSC7337, Bethesda, MD 20892-7337, USA. stoddaja@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - S87 EP - S93 VL - 8 Suppl 1 SN - 1462-2203, 1462-2203 KW - Index Medicus KW - Information Storage and Retrieval -- statistics & numerical data KW - Reproducibility of Results KW - Tobacco Use Disorder -- rehabilitation KW - Humans KW - Information Dissemination KW - Health Education -- statistics & numerical data KW - Adult KW - Middle Aged KW - Program Evaluation KW - Information Services -- utilization KW - United States -- epidemiology KW - Quality Control KW - Female KW - Male KW - Internet -- utilization KW - Smoking Cessation -- methods KW - User-Computer Interface KW - Smoking -- prevention & control KW - Internet -- organization & administration KW - Consumer Behavior -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68351163?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.atitle=The+importance+of+usability+testing+in+the+development+of+an+internet-based+smoking+cessation+treatment+resource.&rft.au=Stoddard%2C+Jacqueline+L%3BAugustson%2C+Erik+M%3BMabry%2C+Patricia+L&rft.aulast=Stoddard&rft.aufirst=Jacqueline&rft.date=2006-12-01&rft.volume=8+Suppl+1&rft.issue=&rft.spage=S87&rft.isbn=&rft.btitle=&rft.title=Nicotine+%26+tobacco+research+%3A+official+journal+of+the+Society+for+Research+on+Nicotine+and+Tobacco&rft.issn=14622203&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-19 N1 - Date created - 2007-05-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic and environmental influences on the development of alcoholism: resilience vs. risk. AN - 68326434; 17347351 AB - The physiological changes of adolescence may promote risk-taking behaviors, including binge drinking. Approximately 40% of alcoholics were already drinking heavily in late adolescence. Most cases of alcoholism are established by the age of 30 years with the peak prevalence at 18-23 years of age. Therefore the key time frame for the development, and prevention, of alcoholism lies in adolescence and young adulthood. Severe childhood stressors have been associated with increased vulnerability to addiction, however, not all stress-exposed children go on to develop alcoholism. Origins of resilience can be both genetic (variation in alcohol-metabolizing genes, increased susceptibility to alcohol's sedative effects) and environmental (lack of alcohol availability, positive peer and parental support). Genetic vulnerability is likely to be conferred by multiple genes of small to modest effects, possibly only apparent in gene-environment interactions. For example, it has been shown that childhood maltreatment interacts with a monoamine oxidase A (MAOA) gene variant to predict antisocial behavior that is often associated with alcoholism, and an interaction between early life stress and a serotonin transporter promoter variant predicts alcohol abuse in nonhuman primates and depression in humans. In addition, a common Met158 variant in the catechol-O-methyltransferase (COMT) gene can confer both risk and resilience to alcoholism in different drinking environments. It is likely that a complex mix of gene(s)-environment(s) interactions underlie addiction vulnerability and development. Risk-resilience factors can best be determined in longitudinal studies, preferably starting during pregnancy. This kind of research is important for planning future measures to prevent harmful drinking in adolescence. JF - Annals of the New York Academy of Sciences AU - Enoch, Mary-Anne AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland, USA. maenoch@niaaa.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 193 EP - 201 VL - 1094 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Risk Factors KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Environment KW - Alcoholism -- etiology KW - Adaptation, Psychological KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68326434?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Genetic+and+environmental+influences+on+the+development+of+alcoholism%3A+resilience+vs.+risk.&rft.au=Enoch%2C+Mary-Anne&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2006-12-01&rft.volume=1094&rft.issue=&rft.spage=193&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2007-03-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Motion-perception deficits and reading impairment: it's the noise, not the motion. AN - 68280466; 17201786 AB - We tested the hypothesis that deficits on sensory-processing tasks frequently associated with poor reading and dyslexia are the result of impairments in external-noise exclusion, rather than motion perception or magnocellular processing. We compared the motion-direction discrimination thresholds of adults and children with good or poor reading performance, using coherent-motion displays embedded in external noise. Both adults and children who were poor readers had higher thresholds than their respective peers in the presence of high external noise, but not in the presence of low external noise or when the signal was clearly demarcated. Adults' performance in high external noise correlated with their general reading ability, whereas children's performance correlated with their language and verbal abilities. The results support the hypothesis that noise-exclusion deficits impair reading and language development and suggest that the impact of such deficits on the development of reading skills changes with age. JF - Psychological science AU - Sperling, Anne J AU - Lu, Zhong-Lin AU - Manis, Franklin R AU - Seidenberg, Mark S AD - Georgetown University Medical Center, USA. sperlinga@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1047 EP - 1053 VL - 17 IS - 12 SN - 0956-7976, 0956-7976 KW - Index Medicus KW - Students -- psychology KW - Language Tests KW - Perceptual Masking -- physiology KW - Age Factors KW - Discrimination (Psychology) -- physiology KW - Humans KW - Verbal Behavior -- physiology KW - Child KW - Cognition -- physiology KW - Auditory Perception -- physiology KW - Adult KW - Task Performance and Analysis KW - Psychoacoustics KW - Language KW - Adolescent KW - Female KW - Male KW - Motion KW - Dyslexia -- psychology KW - Motion Perception -- physiology KW - Noise UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68280466?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+science&rft.atitle=Motion-perception+deficits+and+reading+impairment%3A+it%27s+the+noise%2C+not+the+motion.&rft.au=Sperling%2C+Anne+J%3BLu%2C+Zhong-Lin%3BManis%2C+Franklin+R%3BSeidenberg%2C+Mark+S&rft.aulast=Sperling&rft.aufirst=Anne&rft.date=2006-12-01&rft.volume=17&rft.issue=12&rft.spage=1047&rft.isbn=&rft.btitle=&rft.title=Psychological+science&rft.issn=09567976&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-23 N1 - Date created - 2007-01-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CT fluoroscopy shielding: decreases in scattered radiation for the patient and operator. AN - 68270635; 17185699 AB - High-radiation exposure occurs during computed tomographic (CT) fluoroscopy. Patient and operator doses during thoracic and abdominal interventional procedures were studied in the present experiment, and a novel shielding device to reduce exposure to the patient and operator was evaluated. With a 16-slice CT scanner in CT fluoroscopy mode (120 kVp, 30 mA), surface dosimetry was performed on adult and pediatric phantoms. The shielding was composed of tungsten antimony in the form of a lightweight polymer sheet. Doses to the patient were measured with and without shielding for thoracic and abdominal procedures. Doses to the operator were recorded with and without phantom, gantry, and table shielding in place. Double-layer lead-free gloves were used by the operator during the procedures. Tungsten antimony shielding adjacent to the scan plane resulted in a maximum dose reduction of 92.3% to the patient. Maximum 85.6%, 93.3%, and 85.1% dose reductions were observed for the operator's torso, gonads, and hands, respectively. The use of double-layer lead-free gloves resulted in a maximum radiation dose reduction of 97%. Methods to reduce exposure during CT fluoroscopy are effective and should be searched for. Significant reduction in radiation doses to the patient and operator can be accomplished with tungsten antimony shielding. JF - Journal of vascular and interventional radiology : JVIR AU - Neeman, Ziv AU - Dromi, Sergio A AU - Sarin, Shawn AU - Wood, Bradford J AD - Department of Diagnostic Radiology, National Institutes of Health, Clinical Center, Building 10, Room 1C 660, 10 Center Drive, Bethesda, Maryland 20892-1182, USA. zneeman@cc.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1999 EP - 2004 VL - 17 IS - 12 SN - 1051-0443, 1051-0443 KW - Antimony KW - 9IT35J3UV3 KW - Tungsten KW - V9306CXO6G KW - Index Medicus KW - Phantoms, Imaging KW - Radiation Dosage KW - Gloves, Protective KW - Occupational Exposure -- prevention & control KW - Scattering, Radiation KW - Humans KW - Tomography, X-Ray Computed KW - Fluoroscopy KW - Radiation Injuries -- prevention & control KW - Radiography, Interventional KW - Radiation Protection -- instrumentation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68270635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.atitle=CT+fluoroscopy+shielding%3A+decreases+in+scattered+radiation+for+the+patient+and+operator.&rft.au=Neeman%2C+Ziv%3BDromi%2C+Sergio+A%3BSarin%2C+Shawn%3BWood%2C+Bradford+J&rft.aulast=Neeman&rft.aufirst=Ziv&rft.date=2006-12-01&rft.volume=17&rft.issue=12&rft.spage=1999&rft.isbn=&rft.btitle=&rft.title=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.issn=10510443&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2006-12-22 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Radiology. 2001 May;219(2):515-20 [11323481] J Vasc Interv Radiol. 2000 Jul-Aug;11(7):879-84 [10928526] Radiology. 2000 Jul;216(1):180-4 [10887246] AJR Am J Roentgenol. 2000 Apr;174(4):939-42 [10749226] BMJ. 2000 Mar 4;320(7235):593-4 [10698858] Radiology. 2002 Oct;225(1):277-82 [12355016] Cardiovasc Intervent Radiol. 2005 Sep-Oct;28(5):589-94 [16132384] AJR Am J Roentgenol. 2003 Feb;180(2):407-11 [12540443] Radiology. 1976 Mar;118(3):603-7 [1251009] Radiology. 1984 Jun;151(3):799 [6718743] Radiology. 1985 Jun;155(3):825 [4001386] Radiology. 1986 Jun;159(3):801-3 [3704160] N Engl J Med. 1990 May 10;322(19):1364-74 [2183060] Health Phys. 1991 May;60(5):661-4 [2019497] Health Phys. 1991 Dec;61(6):917-8 [1955342] J Vasc Interv Radiol. 1994 Jan-Feb;5(1):71-84 [8136601] Radiology. 1996 Sep;200(3):851-6 [8756943] Radiology. 1996 Nov;201(2):576-8 [8888264] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Fonofos exposure and cancer incidence in the agricultural health study. AN - 68264639; 17185272 AB - The Agricultural Health Study (AHS) is a prospective cohort study of licensed pesticide applicators from Iowa and North Carolina enrolled 1993-1997 and followed for incident cancer through 2002. A previous investigation in this cohort linked exposure to the organophosphate fonofos with incident prostate cancer in subjects with family history of prostate cancer. This finding along with findings of associations between organophosphate pesticides and cancer more broadly led to this study of fonofos and risk of any cancers among 45,372 pesticide applicators enrolled in the AHS. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Relative to the unexposed, leukemia risk was elevated in the highest category of lifetime (RR = 2.24; 95% CI, 0.94-5.34, Ptrend = 0.07) and intensity-weighted exposure-days (RR = 2.67; 95% CI, 1.06-6.70, Ptrend = 0.04), a measure that takes into account factors that modify pesticide exposure. Although prostate cancer risk was unrelated to fonofos use overall, among applicators with a family history of prostate cancer, we observed a significant dose-response trend for lifetime exposure-days (Ptrend = 0.02, RR highest tertile vs. unexposed = 1.77, 95% CI, 1.03-3.05; RRinteraction = 1.28, 95% CI, 1.07-1.54). Intensity-weighted results were similar. No associations were observed with other examined cancer sites. Further study is warranted to confirm findings with respect to leukemia and determine whether genetic susceptibility modifies prostate cancer risk from pesticide exposure. JF - Environmental health perspectives AU - Mahajan, Rajeev AU - Blair, Aaron AU - Lynch, Charles F AU - Schroeder, Paul AU - Hoppin, Jane A AU - Sandler, Dale P AU - Alavanja, Michael C R AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1838 EP - 1842 VL - 114 IS - 12 SN - 0091-6765, 0091-6765 KW - Organophosphorus Compounds KW - 0 KW - Organothiophosphorus Compounds KW - Pesticides KW - Fonofos KW - P4VT8081QO KW - Index Medicus KW - Pesticides -- analysis KW - Organophosphorus Compounds -- analysis KW - Regression Analysis KW - Humans KW - North Carolina -- epidemiology KW - Poisson Distribution KW - Adult KW - Organothiophosphorus Compounds -- analysis KW - Organothiophosphorus Compounds -- poisoning KW - Family Health KW - Male KW - Iowa -- epidemiology KW - Prostatic Neoplasms -- epidemiology KW - Organophosphate Poisoning KW - Agricultural Workers' Diseases -- chemically induced KW - Pesticides -- poisoning KW - Prostatic Neoplasms -- genetics KW - Prostatic Neoplasms -- etiology KW - Prospective Studies KW - Risk Factors KW - Agricultural Workers' Diseases -- epidemiology KW - Cohort Studies KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - Female KW - Agriculture KW - Occupational Exposure -- statistics & numerical data KW - Fonofos -- poisoning KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Occupational Exposure -- adverse effects KW - Fonofos -- analysis KW - Occupational Exposure -- analysis KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68264639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Fonofos+exposure+and+cancer+incidence+in+the+agricultural+health+study.&rft.au=Mahajan%2C+Rajeev%3BBlair%2C+Aaron%3BLynch%2C+Charles+F%3BSchroeder%2C+Paul%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BAlavanja%2C+Michael+C+R&rft.aulast=Mahajan&rft.aufirst=Rajeev&rft.date=2006-12-01&rft.volume=114&rft.issue=12&rft.spage=1838&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-13 N1 - Date created - 2006-12-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Feb 7;143(1):1-118 [10675783] Epidemiology. 2006 Jan;17(1):69-74 [16357597] Cancer Causes Control. 2001 Aug;12(6):509-17 [11519759] J Pharmacol Exp Ther. 2001 Dec;299(3):825-31 [11714865] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):418-26 [12415490] Drug Metab Dispos. 2003 Apr;31(4):384-91 [12642463] Am J Epidemiol. 2003 May 1;157(9):800-14 [12727674] Occup Environ Med. 2003 Sep;60(9):E11 [12937207] Life Sci. 2003 Dec 26;74(6):675-96 [14654162] Int J Cancer. 2004 Aug 20;111(2):298-302 [15197786] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Mutat Res. 1982 Mar;101(1):19-29 [7043246] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] Arch Environ Health. 1993 Sep-Oct;48(5):353-8 [8215601] Environ Health Perspect. 1996 Apr;104(4):362-9 [8732939] Scand J Work Environ Health. 1996 Aug;22(4):285-93 [8881017] Drug Metab Dispos. 2001 Sep;29(9):1201-4 [11502728] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin. AN - 68253805; 17172403 AB - Although expressing adequate levels of functional tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR4/DR5, significant proportion of cancer cells exhibit resistance to the cytotoxic effect of this ligand. Exposure of Apo2L/TRAIL-refractory cancer cells to cytotoxic chemotherapeutic agents enhances their sensitivity to Apo2L/TRAIL cytotoxicity. This study aims to elucidate the molecular mechanism responsible for the cisplatin-mediated enhancement of Apo2L/TRAIL sensitivity in cultured esophageal cancer cells. Exposure of cancer cells to sublethal concentrations of cisplatin resulted in profound potentiation of their susceptibility to Apo2L/TRAIL cytotoxicity as indicated by 2- to >20-fold reduction in Apo2L/TRAIL IC50 values. Significant activation of caspase-8, caspase-9, and caspase-3 was observed only in cells treated with cisplatin/Apo2L/TRAIL combination and not in those exposed to either agent alone. More importantly, activation of these key caspases was significantly abrogated by overexpression of Bcl2 or by the selective caspase-9 inhibitor. This observation strongly suggested that caspase-8 activation in cells treated with the cisplatin/Apo2L/TRAIL combination was secondary to the mitochondria-mediated amplification feedback loop and activation of the executioner caspase-3 was dependent on the recruitment of the intrinsic pathway characteristic of the type II cell. Profound combination-mediated cytotoxicity and induction of apoptosis was completely suppressed either by Bcl2 overexpression or by inhibition of caspase-9 activity, which conclusively pointed to the essential role of the mitochondria-dependent death signaling cascade in this process. Cisplatin sensitizes esophageal cancer cells to Apo2L/TRAIL cytotoxicity by potentiation of the mitochondria-dependent death signaling pathway that leads to amplification of caspase activation, particularly caspase-8, by the feedback loop to efficiently induce apoptosis. JF - Molecular cancer therapeutics AU - Tsai, Wilson S AU - Yeow, Wen-Shuz AU - Chua, Alex AU - Reddy, Rishindra M AU - Nguyen, Duc M AU - Schrump, David S AU - Nguyen, Dao M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Room 4-4W-3940, 10 Center Drive, Bethesda, MD 20892-1502, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2977 EP - 2990 VL - 5 IS - 12 SN - 1535-7163, 1535-7163 KW - Death Domain Receptor Signaling Adaptor Proteins KW - 0 KW - Isoenzymes KW - Proto-Oncogene Proteins c-bcl-2 KW - TNF-Related Apoptosis-Inducing Ligand KW - Caspases KW - EC 3.4.22.- KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Proto-Oncogene Proteins c-bcl-2 -- biosynthesis KW - Death Domain Receptor Signaling Adaptor Proteins -- biosynthesis KW - Drug Screening Assays, Antitumor KW - Enzyme Activation KW - Humans KW - Mitochondria -- drug effects KW - Apoptosis -- drug effects KW - Mitochondria -- metabolism KW - Cell Line, Tumor KW - Drug Synergism KW - Isoenzymes -- metabolism KW - Caspases -- metabolism KW - TNF-Related Apoptosis-Inducing Ligand -- pharmacology KW - Esophageal Neoplasms -- metabolism KW - TNF-Related Apoptosis-Inducing Ligand -- administration & dosage KW - Cisplatin -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Esophageal Neoplasms -- pathology KW - Esophageal Neoplasms -- drug therapy KW - Cisplatin -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68253805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Enhancement+of+Apo2L%2FTRAIL-mediated+cytotoxicity+in+esophageal+cancer+cells+by+cisplatin.&rft.au=Tsai%2C+Wilson+S%3BYeow%2C+Wen-Shuz%3BChua%2C+Alex%3BReddy%2C+Rishindra+M%3BNguyen%2C+Duc+M%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Tsai&rft.aufirst=Wilson&rft.date=2006-12-01&rft.volume=5&rft.issue=12&rft.spage=2977&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2006-12-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Very high-dose methotrexate (33.6 g/m(2)) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children's Cancer Group trials CCG-191P, CCG-134P and CCG-144P. AN - 68248300; 17169794 AB - Between 1977 and 1991, the Children's Cancer Group and the National Cancer Institute conducted three trials of very high-dose methotrexate (33.6 g/m2; VHD-MTX) in place of cranial radiation (CRT) as central nervous system (CNS) preventive therapy, and assessed efficacy, acute toxicity and long-term neurocognitive outcome. CCG-191P compared VHD-MTX to CRT plus intrathecal methotrexate (IT-MTX) in 181 patients and demonstrated equivalent survival. However, patients treated with CRT had poorer performance on neurocognitive testing over time. CCG-134P evaluated the addition of intensified systemic and intrathecal therapy to VHD-MTX in 128 patients with high-risk acute lymphoblastic leukemia (ALL) and demonstrated reduced CNS relapse compared to the CCG-191P trial, but equivalent survival. CCG-144P compared VHD-MTX to IT-MTX alone in 175 patients with average-risk ALL and demonstrated equivalent survival. VHD-MTX was associated with significant toxicities, particularly neutropenia, transient hepatic dysfunction and sepsis. VHD-MTX achieved similar survival to other CNS-directed therapies without the long-term impact on intelligence, but with substantial acute toxicities. JF - Leukemia & lymphoma AU - Nathan, Paul C AU - Whitcomb, Trish AU - Wolters, Pamela L AU - Steinberg, Seth M AU - Balis, Frank M AU - Brouwers, Pim AU - Hunsberger, Sally AU - Feusner, James AU - Sather, Harland AU - Miser, James AU - Odom, Lorrie F AU - Poplack, David AU - Reaman, Gregory AU - Bleyer, W Archie AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2488 EP - 2504 VL - 47 IS - 12 SN - 1042-8194, 1042-8194 KW - Methotrexate KW - YL5FZ2Y5U1 KW - Index Medicus KW - Infant KW - Risk KW - Cognition -- drug effects KW - Humans KW - Adult KW - Treatment Outcome KW - Pilot Projects KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Methotrexate -- therapeutic use KW - Central Nervous System Neoplasms -- prevention & control KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68248300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia+%26+lymphoma&rft.atitle=Very+high-dose+methotrexate+%2833.6+g%2Fm%282%29%29+as+central+nervous+system+preventive+therapy+for+childhood+acute+lymphoblastic+leukemia%3A+results+of+National+Cancer+Institute%2FChildren%27s+Cancer+Group+trials+CCG-191P%2C+CCG-134P+and+CCG-144P.&rft.au=Nathan%2C+Paul+C%3BWhitcomb%2C+Trish%3BWolters%2C+Pamela+L%3BSteinberg%2C+Seth+M%3BBalis%2C+Frank+M%3BBrouwers%2C+Pim%3BHunsberger%2C+Sally%3BFeusner%2C+James%3BSather%2C+Harland%3BMiser%2C+James%3BOdom%2C+Lorrie+F%3BPoplack%2C+David%3BReaman%2C+Gregory%3BBleyer%2C+W+Archie&rft.aulast=Nathan&rft.aufirst=Paul&rft.date=2006-12-01&rft.volume=47&rft.issue=12&rft.spage=2488&rft.isbn=&rft.btitle=&rft.title=Leukemia+%26+lymphoma&rft.issn=10428194&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-26 N1 - Date created - 2006-12-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - "Similarity trap" in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains. AN - 68244133; 17161371 AB - Similar binding sites often imply similar protein-protein interactions and similar functions; however, similar binding sites may also constitute traps for nonfunctional associations. How are similar sites distinguished to prevent misassociations? BRCT domains from breast cancer-susceptibility gene product BRCA1 and protein 53BP1 have similar structures yet different binding behaviors with p53 core domain. 53BP1-BRCT domain forms a stable complex with p53. In contrast, BRCA1-p53 interaction is weak or other mechanisms operate. To delineate the difference, we designed 13 BRCA1-BRCT mutants and computationally investigated the structural and stability changes compared to the experimental p53-53BP1 structure. Interestingly, of the 13, the 2 mutations that are cancerous and involve nonconserved residues are those that enforced p53 core domain binding with BRCA1-BRCT in a way similar to p53-53BP1 binding. Hence, falling into the "similarity trap" may disrupt normal BRCA1 and p53 functions. Our results illustrate how this trap is avoided in the native state. JF - Structure (London, England : 1993) AU - Liu, Jin AU - Pan, Yongping AU - Ma, Buyong AU - Nussinov, Ruth AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1811 EP - 1821 VL - 14 IS - 12 SN - 0969-2126, 0969-2126 KW - BRCA1 Protein KW - 0 KW - Intracellular Signaling Peptides and Proteins KW - Phosphoproteins KW - TP53 protein, human KW - TP53BP1 protein, human KW - Tumor Suppressor Protein p53 KW - Tumor Suppressor p53-Binding Protein 1 KW - Index Medicus KW - Protein Structure, Secondary KW - Computer Simulation KW - Thermodynamics KW - Models, Molecular KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Protein Structure, Tertiary KW - Protein Binding KW - Mutation KW - Binding Sites KW - Phosphoproteins -- chemistry KW - Intracellular Signaling Peptides and Proteins -- chemistry KW - Tumor Suppressor Protein p53 -- chemistry KW - Protein Interaction Mapping -- methods KW - BRCA1 Protein -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68244133?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Structure+%28London%2C+England+%3A+1993%29&rft.atitle=%22Similarity+trap%22+in+protein-protein+interactions+could+be+carcinogenic%3A+simulations+of+p53+core+domain+complexed+with+53BP1+and+BRCA1+BRCT+domains.&rft.au=Liu%2C+Jin%3BPan%2C+Yongping%3BMa%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Liu&rft.aufirst=Jin&rft.date=2006-12-01&rft.volume=14&rft.issue=12&rft.spage=1811&rft.isbn=&rft.btitle=&rft.title=Structure+%28London%2C+England+%3A+1993%29&rft.issn=09692126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 2002 Mar 1;16(5):583-93 [11877378] Mol Cell Biol. 2002 Jun;22(12):4280-92 [12024039] EMBO J. 2002 Jul 15;21(14):3863-72 [12110597] Genome Res. 2002 Oct;12(10):1540-8 [12368246] Proc Natl Acad Sci U S A. 2003 May 13;100(10):5772-7 [12730379] J Comput Chem. 2003 Aug;24(11):1348-56 [12827676] Bioinformatics. 2003;19 Suppl 1:i158-68 [12855452] J Mol Biol. 2003 Oct 3;332(5):989-98 [14499603] Science. 2003 Oct 24;302(5645):636-9 [14576432] Science. 2003 Oct 24;302(5645):639-42 [14576433] J Mol Med (Berl). 2003 Nov;81(11):700-7 [13679996] Protein Sci. 2004 Mar;13(3):617-25 [14978302] Science. 2004 Mar 26;303(5666):2026-9 [15044803] Adv Cancer Res. 2000;77:81-137 [10549356] Nat Struct Mol Biol. 2004 Jun;11(6):519-25 [15133503] Trends Biochem Sci. 2004 Nov;29(11):579-85 [15501676] Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6098-102 [8016121] Science. 1994 Oct 7;266(5182):120-2 [7939630] Science. 1994 Oct 7;266(5182):66-71 [7545954] Nat Genet. 1996 Jul;13(3):266-8 [8673121] Oncogene. 1998 Apr 2;16(13):1713-21 [9582019] J Biol Chem. 1998 Oct 2;273(40):26061-8 [9748285] Oncogene. 1999 Jan 7;18(1):263-8 [9926942] Science. 1999 Jul 30;285(5428):751-3 [10427000] J Mol Biol. 2005 Jan 14;345(2):275-87 [15571721] Biochemistry. 2004 Dec 28;43(51):15983-95 [15609993] Biochemistry. 2005 Aug 23;44(33):10941-6 [16101277] BMC Bioinformatics. 2005;6:240 [16194281] Genes Dev. 2001 May 15;15(10):1188-93 [11358863] Cancer Biol Ther. 2005 Dec;4(12):1409-14 [16357511] Nat Struct Biol. 2001 Dec;8(12):1015-9 [11702069] Nat Struct Biol. 2001 Oct;8(10):838-42 [11573086] Nat Struct Mol Biol. 2004 Jun;11(6):512-8 [15133502] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Identification of a novel gene, URE2, that functionally complements a urease-negative clinical strain of Cryptococcus neoformans. AN - 68242442; 17159224 AB - A urease-negative serotype A strain of Cryptococcus neoformans (B-4587) was isolated from the cerebrospinal fluid of an immunocompetent patient with a central nervous system infection. The URE1 gene encoding urease failed to complement the mutant phenotype. Urease-positive clones of B-4587 obtained by complementing with a genomic library of strain H99 harboured an episomal plasmid containing DNA inserts with homology to the sudA gene of Aspergillus nidulans. The gene harboured by these plasmids was named URE2 since it enabled the transformants to grow on media containing urea as the sole nitrogen source while the transformants with an empty vector failed to grow. Transformation of strain B-4587 with a plasmid construct containing a truncated version of the URE2 gene failed to complement the urease-negative phenotype. Disruption of the native URE2 gene in a wild-type serotype A strain H99 and a serotype D strain LP1 of C. neoformans resulted in the inability of the strains to grow on media containing urea as the sole nitrogen source, suggesting that the URE2 gene product is involved in the utilization of urea by the organism. Virulence in mice of the urease-negative isolate B-4587, the urease-positive transformants containing the wild-type copy of the URE2 gene, and the urease-negative vector-only transformants was comparable to that of the H99 strain of C. neoformans regardless of the infection route. Virulence of the URE2 disruption stain of H99 was slightly reduced compared to the wild-type strain in the intravenous model but was significantly attenuated in the inhalation model. These results indicate that the importance of urease activity in pathogenicity varies depending on the strains of C. neoformans used and/or the route of infection. Furthermore, this study shows that complementation cloning can serve as a useful tool to functionally identify genes such as URE2 that have otherwise been annotated as hypothetical proteins in genomic databases. JF - Microbiology (Reading, England) AU - Varma, Ashok AU - Wu, Shaoxi AU - Guo, Ningru AU - Liao, Wanqing AU - Lu, Guxia AU - Li, Anshen AU - Hu, Yonglin AU - Bulmer, Glenn AU - Kwon-Chung, Kyung J AD - Molecular Microbiology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 3723 EP - 3731 VL - 152 SN - 1350-0872, 1350-0872 KW - DNA, Fungal KW - 0 KW - Urea KW - 8W8T17847W KW - Urease KW - EC 3.5.1.5 KW - Nitrogen KW - N762921K75 KW - Index Medicus KW - Urea -- metabolism KW - Animals KW - Central Nervous System Fungal Infections -- microbiology KW - Electroporation KW - Humans KW - Cerebrospinal Fluid -- microbiology KW - Disease Models, Animal KW - Mice KW - Sequence Analysis, DNA KW - Genomic Library KW - Nitrogen -- metabolism KW - Gene Deletion KW - Aspergillus nidulans -- genetics KW - Cryptococcosis -- microbiology KW - Transformation, Genetic KW - Genetic Complementation Test KW - Sequence Homology, Amino Acid KW - Mutagenesis, Insertional KW - Cryptococcus neoformans -- isolation & purification KW - Cryptococcus neoformans -- enzymology KW - Urease -- genetics KW - Virulence -- genetics KW - Cryptococcus neoformans -- genetics KW - Cryptococcus neoformans -- pathogenicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68242442?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Microbiology+%28Reading%2C+England%29&rft.atitle=Identification+of+a+novel+gene%2C+URE2%2C+that+functionally+complements+a+urease-negative+clinical+strain+of+Cryptococcus+neoformans.&rft.au=Varma%2C+Ashok%3BWu%2C+Shaoxi%3BGuo%2C+Ningru%3BLiao%2C+Wanqing%3BLu%2C+Guxia%3BLi%2C+Anshen%3BHu%2C+Yonglin%3BBulmer%2C+Glenn%3BKwon-Chung%2C+Kyung+J&rft.aulast=Varma&rft.aufirst=Ashok&rft.date=2006-12-01&rft.volume=152&rft.issue=&rft.spage=3723&rft.isbn=&rft.btitle=&rft.title=Microbiology+%28Reading%2C+England%29&rft.issn=13500872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer. AN - 68238428; 17157789 AB - A serious obstacle to successful treatment of estrogen receptor (ER)-positive human breast cancer is cell resistance to tamoxifen (TAM) therapy. Here we show that the electrophile disulfide benzamide (DIBA), an ER zinc finger inhibitor, blocks ligand-dependent and -independent cell growth of TAM-resistant breast cancer in vitro and in vivo. Such inhibition depends on targeting disruption of the ER DNA-binding domain and its communication with neighboring functional domains, facilitating ERalpha dissociation from its coactivator AIB1 and concomitant association with its corepressor NCoR bound to chromatin. DIBA does not affect phosphorylation of HER2, MAPK, AKT, and AIB1, suggesting that DIBA-modified ERalpha may induce a switch from agonistic to antagonistic effects of TAM on resistant breast cancer cells. JF - Cancer cell AU - Wang, Li Hua AU - Yang, Xiao Yi AU - Zhang, Xiaohu AU - An, Ping AU - Kim, Han-Jong AU - Huang, Jiaqiang AU - Clarke, Robert AU - Osborne, C Kent AU - Inman, John K AU - Appella, Ettore AU - Farrar, William L AD - Basic Research Program, SAIC-Frederick, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA. lhwang@ncifcrf.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 487 EP - 499 VL - 10 IS - 6 SN - 1535-6108, 1535-6108 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Benzamides KW - Estrogen Receptor alpha KW - Tamoxifen KW - 094ZI81Y45 KW - benzamide KW - 6X80438640 KW - DNA KW - 9007-49-2 KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Proto-Oncogene Proteins c-akt KW - EC 2.7.11.1 KW - Index Medicus KW - Animals KW - Proto-Oncogene Proteins c-akt -- metabolism KW - Receptor, ErbB-2 -- metabolism KW - Humans KW - Cell Line, Tumor KW - Drug Resistance, Neoplasm KW - Mice KW - Binding Sites KW - Promoter Regions, Genetic KW - Phosphorylation KW - Response Elements KW - Drug Synergism KW - Cell Cycle -- drug effects KW - Female KW - Breast Neoplasms -- drug therapy KW - Tamoxifen -- pharmacology KW - Benzamides -- pharmacology KW - DNA -- metabolism KW - Antineoplastic Agents, Hormonal -- pharmacology KW - Estrogen Receptor alpha -- metabolism KW - Estrogen Receptor alpha -- chemistry KW - Estrogen Receptor alpha -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68238428?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+cell&rft.atitle=Disruption+of+estrogen+receptor+DNA-binding+domain+and+related+intramolecular+communication+restores+tamoxifen+sensitivity+in+resistant+breast+cancer.&rft.au=Wang%2C+Li+Hua%3BYang%2C+Xiao+Yi%3BZhang%2C+Xiaohu%3BAn%2C+Ping%3BKim%2C+Han-Jong%3BHuang%2C+Jiaqiang%3BClarke%2C+Robert%3BOsborne%2C+C+Kent%3BInman%2C+John+K%3BAppella%2C+Ettore%3BFarrar%2C+William+L&rft.aulast=Wang&rft.aufirst=Li&rft.date=2006-12-01&rft.volume=10&rft.issue=6&rft.spage=487&rft.isbn=&rft.btitle=&rft.title=Cancer+cell&rft.issn=15356108&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological treatment of psychiatric comorbidity in bipolar disorder: a review of controlled trials. AN - 68233959; 17156156 AB - Little is known about the treatment of psychiatric comorbidities in bipolar disorder. The aim of this review was to summarize the literature on controlled pharmacological trials that have been conducted in psychiatric conditions that commonly co-occur in bipolar disorder. A Medline search (1980-October 2005) using the terms bipolar disorder and randomized controlled trials, comorbidity, anxiety disorders, alcohol abuse or dependence, substance abuse or dependence, eating disorder, impulse control disorders, attention-deficit disorder, lithium, anticonvulsants, atypical antipsychotic drugs, antidepressants, stimulants was used. The literature establishes a strong association between bipolar disorder and substance abuse/dependence, anxiety disorders, impulse control disorders, eating disorders and attention-deficit hyperactivity disorder. Comorbidity often complicates the diagnosis and the treatment of bipolar disorder and worsens its course of illness and prognosis. Few controlled pharmacological studies have examined the treatment of comorbid conditions in patients with bipolar disorder. Treatment of psychiatric comorbidities in bipolar disorder is not based on controlled data but is largely empirically based. Controlled trials in patients with bipolar disorder and comorbidity are urgently needed. JF - Bipolar disorders AU - Singh, Jaskaran B AU - Zarate, Carlos A AD - Mood and Anxiety Disorders Research Program, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 696 EP - 709 VL - 8 IS - 6 SN - 1398-5647, 1398-5647 KW - Antidepressive Agents KW - 0 KW - Antimanic Agents KW - Index Medicus KW - Humans KW - Comorbidity KW - Disruptive, Impulse Control, and Conduct Disorders -- drug therapy KW - Randomized Controlled Trials as Topic KW - Attention Deficit Disorder with Hyperactivity -- drug therapy KW - Disruptive, Impulse Control, and Conduct Disorders -- epidemiology KW - Anxiety Disorders -- drug therapy KW - Attention Deficit Disorder with Hyperactivity -- epidemiology KW - Bipolar Disorder -- epidemiology KW - Bipolar Disorder -- drug therapy KW - Substance-Related Disorders -- drug therapy KW - Antidepressive Agents -- therapeutic use KW - Antimanic Agents -- therapeutic use KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68233959?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bipolar+disorders&rft.atitle=Pharmacological+treatment+of+psychiatric+comorbidity+in+bipolar+disorder%3A+a+review+of+controlled+trials.&rft.au=Singh%2C+Jaskaran+B%3BZarate%2C+Carlos+A&rft.aulast=Singh&rft.aufirst=Jaskaran&rft.date=2006-12-01&rft.volume=8&rft.issue=6&rft.spage=696&rft.isbn=&rft.btitle=&rft.title=Bipolar+disorders&rft.issn=13985647&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. AN - 68229366; 17162207 AB - Pulmonary function (PF) was studied in 69 consecutive patients with hematologic diseases, with a minimum 5-year (range, 5-13 years) follow-up after allogeneic stem cell transplantation from an HLA-matched sibling. Fifty-six patients (81%) received total body irradiation based myeloablative stem cell transplantation (MT) and 13 (19%) underwent nonmyeloablative stem cell transplantation (NST). Thirty-one patients (45%) developed a late decrease in PF from baseline, 25 with a restrictive and 6 with an obstructive pattern PF abnormality. Twelve patients (17%) were symptomatic, 8 with a severe restrictive PF defect, but none required supplemental oxygen. The incidence of developing a late PF abnormality was comparable in MT (24 of 56) and NST (5 of 13; P = .51). In multivariate analysis, chronic graft-versus-host disease (relative risk, 16) and pretransplantation diffusion capacity for carbon monoxide or forced expiratory volume in the first second <80% predicted were independently associated with a late decrease in PF from baseline (relative risk, 7). Our results indicate that late PF abnormality is common after MT and NST. Patients with a low pretransplantation diffusion capacity for carbon monoxide of or forced expiratory volume in the first second who developed chronic graft-versus-host disease were most severely affected. Longer follow-up is needed to determine whether PF will continue to decrease or reach a plateau and whether more patients with PF abnormality will eventually become symptomatic. JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Savani, Bipin N AU - Montero, Aldemar AU - Srinivasan, Ramaprasad AU - Singh, Anurag AU - Shenoy, Aarthi AU - Mielke, Stephan AU - Rezvani, Katayoun AU - Karimpour, Shervin AU - Childs, Richard AU - Barrett, A John AD - Hematology Branch, National Heart, Lung and Blood, National Institutes of Health, Bethesda, Maryland 20892-1202, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1261 EP - 1269 VL - 12 IS - 12 SN - 1083-8791, 1083-8791 KW - Carbon Monoxide KW - 7U1EE4V452 KW - Index Medicus KW - Humans KW - Hematologic Diseases -- physiopathology KW - Disease Progression KW - Respiratory Insufficiency -- etiology KW - Child KW - Pulmonary Disease, Chronic Obstructive -- physiopathology KW - Forced Expiratory Volume KW - Carbon Monoxide -- pharmacokinetics KW - Comorbidity KW - Transplantation Conditioning -- adverse effects KW - Hematologic Diseases -- surgery KW - Adult KW - Treatment Outcome KW - Adolescent KW - Male KW - Survival Analysis KW - Pulmonary Diffusing Capacity KW - Whole-Body Irradiation -- adverse effects KW - Pulmonary Disease, Chronic Obstructive -- complications KW - Follow-Up Studies KW - Chronic Disease KW - Middle Aged KW - Respiratory Insufficiency -- physiopathology KW - Female KW - Proportional Hazards Models KW - Hematologic Neoplasms -- physiopathology KW - Lung Diseases -- physiopathology KW - Hematologic Neoplasms -- surgery KW - Peripheral Blood Stem Cell Transplantation -- adverse effects KW - Lung Diseases -- complications KW - Postoperative Complications -- etiology KW - Lung -- physiopathology KW - Graft vs Host Disease -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68229366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Chronic+GVHD+and+pretransplantation+abnormalities+in+pulmonary+function+are+the+main+determinants+predicting+worsening+pulmonary+function+in+long-term+survivors+after+stem+cell+transplantation.&rft.au=Savani%2C+Bipin+N%3BMontero%2C+Aldemar%3BSrinivasan%2C+Ramaprasad%3BSingh%2C+Anurag%3BShenoy%2C+Aarthi%3BMielke%2C+Stephan%3BRezvani%2C+Katayoun%3BKarimpour%2C+Shervin%3BChilds%2C+Richard%3BBarrett%2C+A+John&rft.aulast=Savani&rft.aufirst=Bipin&rft.date=2006-12-01&rft.volume=12&rft.issue=12&rft.spage=1261&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=10838791&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-14 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Blood. 1994 Nov 1;84(9):3212-20 [7949192] J Clin Invest. 1995 Jul;96(1):250-9 [7542280] Transplantation. 1997 Apr 27;63(8):1079-86 [9133468] Eur J Med Res. 1996 Apr 18;1(7):343-8 [9364037] Eur Respir J. 1997 Oct;10(10):2301-6 [9387957] Bone Marrow Transplant. 1998 Mar;21(5):431-40 [9535034] Am J Pathol. 1998 Sep;153(3):825-32 [9736031] Blood. 1999 Apr 1;93(7):2196-201 [10090927] Biol Blood Marrow Transplant. 2005 Mar;11(3):223-30 [15744241] Biol Blood Marrow Transplant. 2005 Apr;11(4):288-96 [15812394] Semin Hematol. 2006 Jan;43(1):42-52 [16412788] Curr Opin Oncol. 2006 Mar;18(2):115-9 [16462178] Biol Blood Marrow Transplant. 2006 May;12(5):560-5 [16635791] Bone Marrow Transplant. 2000 Jun;25(12):1263-8 [10871731] Int J Exp Pathol. 2001 Apr;82(2):101-13 [11454101] Bone Marrow Transplant. 2001 Sep;28(5):425-34 [11593314] Chest. 2001 Dec;120(6):1900-6 [11742920] Cancer. 2001 Oct 1;92(7):1949-58 [11745270] Bone Marrow Transplant. 2003 May;31(9):783-8 [12732885] Biol Blood Marrow Transplant. 2004 Jan;10(1):49-57 [14752779] Bone Marrow Transplant. 2004 Mar;33(5):509-17 [14716347] Br J Haematol. 2004 Mar;124(6):777-86 [15009066] Am J Respir Crit Care Med. 2004 Jul 1;170(1):22-48 [15070821] Chest. 1985 Feb;87(2):237-46 [2981658] Ann Intern Med. 1987 Nov;107(5):648-56 [3310793] Blood. 1988 Aug;72(2):621-7 [3042044] Clin Chest Med. 1990 Jun;11(2):323-32 [2189666] Transplantation. 1992 Nov;54(5):802-8 [1359684] Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1393-400 [8503550] Am Rev Respir Dis. 1993 Jun;147(6 Pt 1):1601-6 [8503576] Bone Marrow Transplant. 1993 Sep;12(3):225-31 [8241981] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in the prevalence of major depression and comorbid substance use disorders in the United States between 1991-1992 and 2001-2002. AN - 68227920; 17151166 AB - The authors examined changes in the prevalence of major depression in the United States between 1991-1992 and 2001-2002 and sought to determine whether changes in depression rates were associated with changes in rates of comorbid substance use disorder. Data were drawn from two large (Ns exceeding 42,000) cross-sectional surveys of representative samples of the U.S. population conducted 10 years apart. Both surveys used face-to-face interviews, the same diagnostic criteria, and consistent assessment instruments. Rates of past-year major depressive episode in the total samples and among subjects with and without co-occurring substance use disorders in major demographic groups were compared. From 1991-1992 to 2001-2002, the prevalence of major depression among U.S. adults increased from 3.33% to 7.06%. Increases were statistically significant for whites, blacks, and Hispanics and for all age groups. For Hispanic men overall and Hispanic women 18-29 years of age, rates increased but not significantly. The hypothesis that increases in the rates of depression could be explained by concomitant increases in co-occurring substance use disorders was supported only for black men 18-29 years of age. Rates of major depression rose markedly over the past decade in the United States, and increases were noted for most sociodemographic subgroups of the population. If the prevalence continues to increase at the rate it did during the past decade, the demand for services will increase dramatically in the coming years. JF - The American journal of psychiatry AU - Compton, Wilson M AU - Conway, Kevin P AU - Stinson, Frederick S AU - Grant, Bridget F AD - Division of Epidemiology, Services, and Prevention Research, National Institute on Drug Abuse, NIH, M.S. 9304, 5635 Fishers Lane, Bethesda, MD 20892-9304, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2141 EP - 2147 VL - 163 IS - 12 SN - 0002-953X, 0002-953X KW - Abridged Index Medicus KW - Index Medicus KW - Health Services Accessibility -- trends KW - Cross-Sectional Studies KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - United States -- epidemiology KW - Ethnic Groups -- psychology KW - Male KW - Female KW - Ethnic Groups -- statistics & numerical data KW - Comorbidity KW - Prevalence KW - Substance-Related Disorders -- diagnosis KW - Depressive Disorder, Major -- diagnosis KW - Depressive Disorder, Major -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68227920?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Changes+in+the+prevalence+of+major+depression+and+comorbid+substance+use+disorders+in+the+United+States+between+1991-1992+and+2001-2002.&rft.au=Compton%2C+Wilson+M%3BConway%2C+Kevin+P%3BStinson%2C+Frederick+S%3BGrant%2C+Bridget+F&rft.aulast=Compton&rft.aufirst=Wilson&rft.date=2006-12-01&rft.volume=163&rft.issue=12&rft.spage=2141&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-16 N1 - Date created - 2006-12-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. AN - 68217923; 17133483 AB - Liver fibrosis, a common scarring response to chronic liver injury, is a precursor to cirrhosis and liver cancer. Here, we identified signal transducer and activator of transcription 1 (STAT1) as an important negative regulator in liver fibrosis. Our findings show that disruption of the STAT1 gene accelerated liver fibrosis and hepatic stellate cell (HSC) proliferation in an in vivo model of carbon tetrachloride (CCl4)-induced liver fibrosis. In vitro treatment with IFN-gamma inhibited proliferation and activation of wild-type HSCs, but not STAT1-/- HSCs. Moreover, compared to wild-type cells, cellular proliferation stimulated by serum or platelet-derived growth factor (PDGF) was enhanced and accelerated in STAT1-/- HSCs, which was partially mediated via elevated PDGF receptor beta expression on such cells. Polyinosinic-polycytidylic acid (poly I:C) or IFN-gamma treatment inhibited liver fibrosis in wild-type mice but not in STAT1-/- mice. Induction of NK cell killing of activated HSCs by poly I:C was attenuated in STAT1-/- mice compared to wild-type mice, which was likely due to reduced NKG2D and TRAIL expression on STAT1-/- NK cells. Finally, activation of TGF-beta/Smad3 signaling pathway was accelerated, whereas induction of Smad7 was diminished in the liver of STAT1-/- mice after CCl4 administration compared to wild-type mice. In conclusion, activation of STAT1 attenuates liver fibrosis through inhibition of HSC proliferation, attenuation of TGF-beta signaling, and stimulation of NK cell killing of activated HSCs. STAT1 could be a new therapeutic target for treating liver fibrosis. JF - Hepatology (Baltimore, Md.) AU - Jeong, Won-Il AU - Park, Ogyi AU - Radaeva, Svetlana AU - Gao, Bin AD - Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1441 EP - 1451 VL - 44 IS - 6 SN - 0270-9139, 0270-9139 KW - Platelet-Derived Growth Factor KW - 0 KW - Proto-Oncogene Proteins c-sis KW - STAT1 Transcription Factor KW - Smad3 Protein KW - Smad3 protein, mouse KW - Stat1 protein, mouse KW - becaplermin KW - 1B56C968OA KW - Poly I-C KW - 24939-03-5 KW - Interferon-gamma KW - 82115-62-6 KW - Receptor, Platelet-Derived Growth Factor beta KW - EC 2.7.10.1 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Hepatocytes -- drug effects KW - Apoptosis -- physiology KW - Interferon-gamma -- pharmacology KW - Mice KW - Poly I-C -- pharmacology KW - Signal Transduction -- drug effects KW - Hepatocytes -- cytology KW - Smad3 Protein -- physiology KW - Receptor, Platelet-Derived Growth Factor beta -- biosynthesis KW - Platelet-Derived Growth Factor -- physiology KW - Liver Cirrhosis -- prevention & control KW - Carbon Tetrachloride Poisoning -- pathology KW - STAT1 Transcription Factor -- physiology KW - STAT1 Transcription Factor -- deficiency KW - Killer Cells, Natural -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68217923?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=STAT1+inhibits+liver+fibrosis+in+mice+by+inhibiting+stellate+cell+proliferation+and+stimulating+NK+cell+cytotoxicity.&rft.au=Jeong%2C+Won-Il%3BPark%2C+Ogyi%3BRadaeva%2C+Svetlana%3BGao%2C+Bin&rft.aulast=Jeong&rft.aufirst=Won-Il&rft.date=2006-12-01&rft.volume=44&rft.issue=6&rft.spage=1441&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hepatic precursors derived from murine embryonic stem cells contribute to regeneration of injured liver. AN - 68215369; 17133486 AB - We established an efficient system for differentiation, expansion and isolation of hepatic progenitor cells from mouse embryonic stem (ES) cells and evaluated their capacity to repopulate injured liver. Using mouse ES cells transfected with the green fluorescent protein (GFP) reporter gene regulated by albumin (ALB) enhancer/promoter, we found that a serum-free chemically defined medium supports formation of embryoid bodies (EBs) and differentiation of hepatic lineage cells in the absence of exogenous growth factors or feeder cell layers. The first GFP+ cells expressing ALB were detected in close proximity to "beating" myocytes after 7 days of EB cultures. GFP+ cells increased in number, acquired hepatocyte-like morphology and hepatocyte-specific markers (i.e., ALB, AAT, TO, and G6P), and by 28 days represented more than 30% of cells isolated from EB outgrowths. The FACS-purified GFP+ cells developed into functional hepatocytes without evidence of cell fusion and participated in the repairing of diseased liver when transplanted into MUP-uPA/SCID mice. The ES cell-derived hepatocytes were responsive to normal growth regulation and proliferated at the same rate as the host hepatocytes after an additional growth stimulus from CCl(4)-induced liver injury. The transplanted GFP+ cells also differentiated into biliary epithelial cells. In conclusion, a highly enriched population of committed hepatocyte precursors can be generated from ES cells in vitro for effective cell replacement therapy. JF - Hepatology (Baltimore, Md.) AU - Heo, Jeonghoon AU - Factor, Valentina M AU - Uren, Tania AU - Takahama, Yasushi AU - Lee, Ju-Seog AU - Major, Marian AU - Feinstone, Stephen M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1478 EP - 1486 VL - 44 IS - 6 SN - 0270-9139, 0270-9139 KW - Albumins KW - 0 KW - Proteins KW - enhanced green fluorescent protein KW - major urinary proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Urokinase-Type Plasminogen Activator KW - EC 3.4.21.73 KW - Index Medicus KW - Animals KW - Urokinase-Type Plasminogen Activator -- genetics KW - Promoter Regions, Genetic KW - Green Fluorescent Proteins -- biosynthesis KW - Enhancer Elements, Genetic KW - Albumins -- genetics KW - Mice KW - Flow Cytometry KW - Mice, SCID KW - Cell Proliferation KW - Proteins -- genetics KW - Green Fluorescent Proteins -- genetics KW - Embryonic Stem Cells -- physiology KW - Cell Differentiation KW - Liver Regeneration -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68215369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Hepatic+precursors+derived+from+murine+embryonic+stem+cells+contribute+to+regeneration+of+injured+liver.&rft.au=Heo%2C+Jeonghoon%3BFactor%2C+Valentina+M%3BUren%2C+Tania%3BTakahama%2C+Yasushi%3BLee%2C+Ju-Seog%3BMajor%2C+Marian%3BFeinstone%2C+Stephen+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Heo&rft.aufirst=Jeonghoon&rft.date=2006-12-01&rft.volume=44&rft.issue=6&rft.spage=1478&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gossypol, a phytochemical with BH3-mimetic property, sensitizes cultured thoracic cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand. AN - 68212767; 17140955 AB - Chemotherapeutic agents sensitize cancer cells to Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) via recruitment of the mitochondria-dependent activation of caspase and induction of apoptosis. This study was designed to evaluate whether gossypol, a phytochemical compound with BH3-mimetic property that functions as an inhibitor of Bcl2/BclXL, would sensitize cultured thoracic cancer cells to this death-inducing ligand. Cancer cell lines from the lung (H460, H322), the esophagus (TE2, TE12), and the pleura (H290, H211) or primary normal cells were treated with gossypol+Apo2L/TRAIL combinations. Cell viability and apoptosis were evaluated by (4,5-dimethylthiazo-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and terminal deoxynucleotidyltransferase-mediated dUTP nick-end labeling (TUNEL) assays, respectively. Caspase 9 and 3 specific proteolytic activity in combination-treated cells was determined by fluorometric enzymatic assay. Gossypol, selectively cytotoxic to cancer cells and not primary normal cells, significantly sensitized thoracic cancer cells to Apo2L/TRAIL as indicated by 1.5- to more than 10-fold reduction of Apo2L/TRAIL 50% inhibitory concentration values in cells treated with gossypol+Apo2L/TRAIL combinations. Whereas less than 20% of cancer cells exposed to either gossypol (5 micromol/L) or Apo2L/TRAIL (20 ng/mL) were dead, more than 90% of cells treated with the drug combinations were apoptotic. Combination-induced cytotoxicity and apoptosis was completely abrogated either by overexpression of Bcl2 or by the selective caspase 9 inhibitor. This combination was not toxic to normal cells. Gossypol profoundly sensitizes thoracic cancer cells to the cytotoxic effect of Apo2L/TRAIL via activation of the mitochondria-dependent death signaling pathway. This study provides evidence for the profound anticancer activity of this drug combination and should be further evaluated as a novel targeted molecular therapeutic for thoracic cancers. JF - The Journal of thoracic and cardiovascular surgery AU - Yeow, Wen-Shuz AU - Baras, Aris AU - Chua, Alex AU - Nguyen, Duc M AU - Sehgal, Shailen S AU - Schrump, David S AU - Nguyen, Dao M AD - Section of Thoracic Oncology, Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Md, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1356 EP - 1362 VL - 132 IS - 6 KW - TNF-Related Apoptosis-Inducing Ligand KW - 0 KW - Gossypol KW - KAV15B369O KW - Abridged Index Medicus KW - Index Medicus KW - Tumor Cells, Cultured KW - Humans KW - Cell Death -- drug effects KW - TNF-Related Apoptosis-Inducing Ligand -- drug effects KW - Apoptosis -- drug effects KW - Pleural Neoplasms -- pathology KW - Mesothelioma -- pathology KW - TNF-Related Apoptosis-Inducing Ligand -- physiology KW - Gossypol -- pharmacology KW - Lung Neoplasms -- pathology KW - Esophageal Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68212767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+thoracic+and+cardiovascular+surgery&rft.atitle=Gossypol%2C+a+phytochemical+with+BH3-mimetic+property%2C+sensitizes+cultured+thoracic+cancer+cells+to+Apo2+ligand%2Ftumor+necrosis+factor-related+apoptosis-inducing+ligand.&rft.au=Yeow%2C+Wen-Shuz%3BBaras%2C+Aris%3BChua%2C+Alex%3BNguyen%2C+Duc+M%3BSehgal%2C+Shailen+S%3BSchrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Yeow&rft.aufirst=Wen-Shuz&rft.date=2006-12-01&rft.volume=132&rft.issue=6&rft.spage=1356&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+thoracic+and+cardiovascular+surgery&rft.issn=1097-685X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-25 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 3-Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP-elicited damage both in vivo and in vitro. AN - 68209955; 17142799 AB - We investigated the neuroprotective property of analogs of dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify neuroprotective drugs for Parkinson's disease (PD). In vivo studies showed that daily injections with DM analogs protected dopamine (DA) neurons in substantia nigra pars compacta and restored DA levels in striatum using two different models for PD. Of the five analogs studied, 3-hydroxymorphinan (3-HM), a metabolite of DM, was the most potent, and restored DA neuronal loss and DA depletion up to 90% of the controls. Behavioral studies showed an excellent correlation between potency for preventing toxin-induced decrease in motor activities and neuroprotective effects among the DM analogs studied, of which 3-HM was the most potent in attenuating behavioral damage. In vitro studies revealed two glia-dependent mechanisms for the neuroprotection by 3-HM. First, astroglia mediated the 3-HM-induced neurotrophic effect by increasing the gene expression of neurotrophic factors, which was associated with the increased acetylation of histone H3. Second, microglia participated in 3-HM-mediated neuroprotection by reducing MPTP-elicited reactive microgliosis as evidenced by the decreased production of reactive oxygen species. In summary, we show the potent neuroprotection by 3-HM in LPS and MPTP PD models investigated. With its high efficacy and low toxicity, 3-HM may be a novel therapy for PD. JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology AU - Zhang, Wei AU - Shin, Eun-Joo AU - Wang, Tongguang AU - Lee, Phil Ho AU - Pang, Hao AU - Wie, Myung-Bok AU - Kim, Won-Ki AU - Kim, Seong-Jin AU - Huang, Wen-Hsin AU - Wang, Yongjun AU - Zhang, Wanqin AU - Hong, Jau-Shyong AU - Kim, Hyoung-Chun AD - Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Science/National Institutes of Health, Research Triangle Park, North Carolina, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2496 EP - 2511 VL - 20 IS - 14 KW - Anti-Inflammatory Agents KW - 0 KW - Lipopolysaccharides KW - Reactive Oxygen Species KW - Dextromethorphan KW - 7355X3ROTS KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine KW - 9P21XSP91P KW - norlevorphanol KW - IL94262N7K KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Molecular Structure KW - Animals KW - Dose-Response Relationship, Drug KW - Astrocytes -- drug effects KW - Anti-Inflammatory Agents -- therapeutic use KW - Substantia Nigra -- drug effects KW - Dopamine -- metabolism KW - Mice KW - Lipopolysaccharides -- adverse effects KW - Substantia Nigra -- metabolism KW - Rats KW - Behavior, Animal -- drug effects KW - Anti-Inflammatory Agents -- chemistry KW - Substantia Nigra -- pathology KW - Mice, Inbred C57BL KW - Astrocytes -- metabolism KW - Dextromethorphan -- metabolism KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- adverse effects KW - Dextromethorphan -- analogs & derivatives KW - Dextromethorphan -- chemistry KW - Parkinsonian Disorders -- chemically induced KW - Dextromethorphan -- therapeutic use KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine -- antagonists & inhibitors KW - Parkinsonian Disorders -- drug therapy KW - Parkinson Disease -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68209955?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.atitle=3-Hydroxymorphinan%2C+a+metabolite+of+dextromethorphan%2C+protects+nigrostriatal+pathway+against+MPTP-elicited+damage+both+in+vivo+and+in+vitro.&rft.au=Zhang%2C+Wei%3BShin%2C+Eun-Joo%3BWang%2C+Tongguang%3BLee%2C+Phil+Ho%3BPang%2C+Hao%3BWie%2C+Myung-Bok%3BKim%2C+Won-Ki%3BKim%2C+Seong-Jin%3BHuang%2C+Wen-Hsin%3BWang%2C+Yongjun%3BZhang%2C+Wanqin%3BHong%2C+Jau-Shyong%3BKim%2C+Hyoung-Chun&rft.aulast=Zhang&rft.aufirst=Wei&rft.date=2006-12-01&rft.volume=20&rft.issue=14&rft.spage=2496&rft.isbn=&rft.btitle=&rft.title=FASEB+journal+%3A+official+publication+of+the+Federation+of+American+Societies+for+Experimental+Biology&rft.issn=1530-6860&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-01 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Combined breast ductal lavage and ductal endoscopy for the evaluation of the high-risk breast: a feasibility study. AN - 68208787; 17048242 AB - Evaluation of the ductal epithelium of the breast at increased risk for breast cancer is needed to define the carcinogenic pathway, for risk assessment, and to improve selection of women for chemoprevention therapy. We studied the feasibility of combining breast ductal endoscopy with ductal lavage in the high-risk contralateral breast of women with ipsilateral breast cancer for the evaluation of high-risk ducts and acquisition of ductal epithelial cells for analysis. Breast ducts were studied by ductal lavage and ductal endoscopy, and epithelial cell content studied cytologically and quantitatively. Twenty-five subjects and 44 ducts, including 22 (50.0%) which did not produce nipple aspirate fluid (NAF), were studied. Cellular atypia was present in five subjects. Ductal endoscopy was performed on 1 or more ducts in 24 subjects. Structural changes were noted in 63.6% of the ducts, most commonly fibrous stranding or bridging. Ductal sampling with endoscopic brush and coil sampling devices provided additional cellular samples of relatively pure ductal epithelial content (> or = 91% purity) in 8/11 subjects. Breast ductal endoscopy combined with ductal lavage represents a feasible approach for characterizing the ducts and ductal epithelium of the high-risk breast, especially in a research setting. (c) 2006 Wiley-Liss, Inc. JF - Journal of surgical oncology AU - Danforth, David N AU - Abati, Andrea AU - Filie, Armando AU - Prindiville, Shiela A AU - Palmieri, Diane AU - Simon, Richard AU - Ried, Thomas AU - Steeg, Patricia S AD - Surgery Branch, The Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. david_danforth@nih.gov Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 555 EP - 564 VL - 94 IS - 7 SN - 0022-4790, 0022-4790 KW - Index Medicus KW - Evaluation Studies as Topic KW - Risk KW - Feasibility Studies KW - Carcinoma, Intraductal, Noninfiltrating -- pathology KW - Therapeutic Irrigation KW - Cell Count KW - Carcinoma, Ductal, Breast -- pathology KW - Cytodiagnosis KW - Body Fluids -- cytology KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Female KW - Risk Assessment KW - Mammary Glands, Human -- cytology KW - Breast Neoplasms -- pathology KW - Endoscopy -- methods KW - Breast Neoplasms -- prevention & control KW - Mammary Glands, Human -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68208787?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+surgical+oncology&rft.atitle=Combined+breast+ductal+lavage+and+ductal+endoscopy+for+the+evaluation+of+the+high-risk+breast%3A+a+feasibility+study.&rft.au=Danforth%2C+David+N%3BAbati%2C+Andrea%3BFilie%2C+Armando%3BPrindiville%2C+Shiela+A%3BPalmieri%2C+Diane%3BSimon%2C+Richard%3BRied%2C+Thomas%3BSteeg%2C+Patricia+S&rft.aulast=Danforth&rft.aufirst=David&rft.date=2006-12-01&rft.volume=94&rft.issue=7&rft.spage=555&rft.isbn=&rft.btitle=&rft.title=Journal+of+surgical+oncology&rft.issn=00224790&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-12-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Surg Oncol. 2006 Dec 1;94(7):553-4 [17111391] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of cytokines in hepatocellular carcinoma. AN - 68204508; 16946019 AB - Hepatocellular carcinoma (HCC) is a frequent malignancy worldwide with a high rate of metastasis. The hepatitis B and C viruses are considered major etiological factors associated with the development of HCC, particularly as a result of their induction of chronic inflammation. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including HCC. Specifically, this review aims to cover evidence for the potential roles of cytokines, an important component of the immune system, in promoting HCC carcinogenesis and progression. A global summary of cytokine levels, functions, polymorphisms, and therapies with regard to HCC is presented. In particular, the role of proinflammatory Th1 and anti-inflammatory Th2 cytokine imbalances in the microenvironment of HCC patients with metastasis and the possible clinical significance of these findings are addressed. Overall, multiple studies, spanning many decades, have begun to elucidate the important role of cytokines in HCC. JF - Journal of leukocyte biology AU - Budhu, Anuradha AU - Wang, Xin Wei AD - National Cancer Institute, 37 Convent Dr., Bldg. 37, Rm. 3044A, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1197 EP - 1213 VL - 80 IS - 6 SN - 0741-5400, 0741-5400 KW - Cytokines KW - 0 KW - Index Medicus KW - Th1 Cells -- immunology KW - Animals KW - Hepatitis B -- immunology KW - Hepatitis C -- complications KW - Humans KW - Hepatitis C -- pathology KW - Hepatitis C -- immunology KW - Hepatitis B -- complications KW - Hepatitis B -- pathology KW - Neoplasm Metastasis KW - Inflammation -- immunology KW - Th2 Cells -- immunology KW - Inflammation -- complications KW - Inflammation -- pathology KW - Cytokines -- genetics KW - Cytokines -- immunology KW - Cell Transformation, Neoplastic -- immunology KW - Liver Neoplasms -- pathology KW - Liver Neoplasms -- therapy KW - Carcinoma, Hepatocellular -- etiology KW - Carcinoma, Hepatocellular -- genetics KW - Carcinoma, Hepatocellular -- therapy KW - Carcinoma, Hepatocellular -- pathology KW - Liver Neoplasms -- etiology KW - Carcinoma, Hepatocellular -- immunology KW - Liver Neoplasms -- genetics KW - Liver Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68204508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=The+role+of+cytokines+in+hepatocellular+carcinoma.&rft.au=Budhu%2C+Anuradha%3BWang%2C+Xin+Wei&rft.aulast=Budhu&rft.aufirst=Anuradha&rft.date=2006-12-01&rft.volume=80&rft.issue=6&rft.spage=1197&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-18 N1 - Date created - 2006-12-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. AN - 68189863; 16969367 AB - Valproate (VPA), one of the mood stabilizers and antiepileptic drugs, was recently found to inhibit histone deacetylases (HDAC). Increasing reports demonstrate that VPA has neurotrophic effects in diverse cell types including midbrain dopaminergic (DA) neurons. However, the origin and nature of the mediator of the neurotrophic effects are unclear. We have previously demonstrated that VPA prolongs the survival of midbrain DA neurons in lipopolysaccharide (LPS)-treated neuron-glia cultures through the inhibition of the release of pro-inflammatory factors from microglia. In this study, we report that VPA upregulates the expression of neurotrophic factors, including glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) from astrocytes and these effects may play a major role in mediating VPA-induced neurotrophic effects on DA neurons. Moreover, VPA pretreatment protects midbrain DA neurons from LPS or 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity. Our study identifies astrocyte as a novel target for VPA to induce neurotrophic and neuroprotective actions in rat midbrain and shows a potential new role of cellular interactions between DA neurons and astrocytes. The neurotrophic and neuroprotective effects of VPA also suggest a utility of this drug for treating neurodegenerative disorders including Parkinson's disease. Moreover, the neurotrophic effects of VPA may contribute to the therapeutic action of this drug in treating bipolar mood disorder that involves a loss of neurons and glia in discrete brain areas. JF - Molecular psychiatry AU - Chen, P-S AU - Peng, G-S AU - Li, G AU - Yang, S AU - Wu, X AU - Wang, C-C AU - Wilson, B AU - Lu, R-B AU - Gean, P-W AU - Chuang, D-M AU - Hong, J-S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1116 EP - 1125 VL - 11 IS - 12 SN - 1359-4184, 1359-4184 KW - Anticonvulsants KW - 0 KW - Brain-Derived Neurotrophic Factor KW - Glial Cell Line-Derived Neurotrophic Factor KW - Valproic Acid KW - 614OI1Z5WI KW - Index Medicus KW - Animals KW - Coculture Techniques KW - Humans KW - Parkinson Disease -- metabolism KW - Parkinson Disease -- drug therapy KW - Rats KW - Rats, Inbred F344 KW - Cell Communication -- drug effects KW - Cells, Cultured KW - Up-Regulation -- drug effects KW - Bipolar Disorder -- drug therapy KW - Bipolar Disorder -- metabolism KW - Female KW - Valproic Acid -- pharmacology KW - Mesencephalon -- metabolism KW - Anticonvulsants -- pharmacology KW - Astrocytes -- cytology KW - Neurons -- metabolism KW - Brain-Derived Neurotrophic Factor -- biosynthesis KW - Glial Cell Line-Derived Neurotrophic Factor -- biosynthesis KW - Neurons -- cytology KW - Mesencephalon -- cytology KW - Astrocytes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68189863?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=Valproate+protects+dopaminergic+neurons+in+midbrain+neuron%2Fglia+cultures+by+stimulating+the+release+of+neurotrophic+factors+from+astrocytes.&rft.au=Chen%2C+P-S%3BPeng%2C+G-S%3BLi%2C+G%3BYang%2C+S%3BWu%2C+X%3BWang%2C+C-C%3BWilson%2C+B%3BLu%2C+R-B%3BGean%2C+P-W%3BChuang%2C+D-M%3BHong%2C+J-S&rft.aulast=Chen&rft.aufirst=P-S&rft.date=2006-12-01&rft.volume=11&rft.issue=12&rft.spage=1116&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=13594184&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-02 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug addiction: the neurobiology of disrupted self-control. AN - 68188886; 17070107 AB - The nature of addiction is often debated along moral versus biological lines. However, recent advances in neuroscience offer insights that might help bridge the gap between these opposing views. Current evidence shows that most drugs of abuse exert their initial reinforcing effects by inducing dopamine surges in limbic regions, affecting other neurotransmitter systems and leading to characteristic plastic adaptations. Importantly, there seem to be intimate relationships between the circuits disrupted by abused drugs and those that underlie self-control. Significant changes can be detected in circuits implicated in reward, motivation and/or drive, salience attribution, inhibitory control and memory consolidation. Therefore, addiction treatments should attempt to reduce the rewarding properties of drugs while enhancing those of alternative reinforcers, inhibit conditioned memories and strengthen cognitive control. We posit that the time has come to recognize that the process of addiction erodes the same neural scaffolds that enable self-control and appropriate decision making. JF - Trends in molecular medicine AU - Baler, Ruben D AU - Volkow, Nora D AD - National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 559 EP - 566 VL - 12 IS - 12 SN - 1471-4914, 1471-4914 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Brain -- physiopathology KW - Models, Psychological KW - Neurobiology KW - Humans KW - Dopamine -- physiology KW - Models, Neurological KW - Neuronal Plasticity KW - Signal Transduction KW - Substance-Related Disorders -- physiopathology KW - Substance-Related Disorders -- etiology KW - Substance-Related Disorders -- drug therapy KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68188886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+molecular+medicine&rft.atitle=Drug+addiction%3A+the+neurobiology+of+disrupted+self-control.&rft.au=Baler%2C+Ruben+D%3BVolkow%2C+Nora+D&rft.aulast=Baler&rft.aufirst=Ruben&rft.date=2006-12-01&rft.volume=12&rft.issue=12&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Trends+in+molecular+medicine&rft.issn=14714914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-11-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A novel imaging technique for experimental choroidal neovascularization. AN - 68182023; 17122098 AB - Choroidal neovascularization (CNV) is the end point of several ocular diseases that lead to blindness. The authors developed an imaging technique for visualizing and quantifying morphologic changes associated with experimental laser-induced CNV. CNV was induced using laser energy to disrupt Bruch's membrane. Rats were euthanatized immediately after laser injury and at 1, 2, 3, 4, 7, 14, and 60 days. Nonlasered eyes were used as the control. Eyes were enucleated and fixed, and the posterior eye cups were fluorescently labeled with markers for nuclei (DAPI; 4',6'-diamino-2-phenylindole), endothelial cells (isolectin IB4), microglia (CD11b), and filamentous actin (phalloidin). FITC-dextran perfusion was compared with our technique. A confocal microscope was used to evaluate flatmounted specimens. Computer software generated three-dimensional reconstructions for qualitative and quantitative analysis of confocal image stacks. In nonlasered areas, RPE cells were visualized as a uniform hexagonal array. Immediately after laser exposure, a circular area devoid of fluorescent labeling was observed, indicating disruption of the choroid-Bruch's membrane-RPE complex. One day after laser exposure, cellular debris and fragmented nuclei were present, and an autofluorescent ring was visible at the site of Bruch's membrane disruption. The ring correlated with bubble formation and CNV induction. Three days after laser injury, phalloidin-labeled RPE cells and isolectin-labeled endothelial cells increased significantly, reflecting cell proliferation and migration. By day 4, isolectin-positive cells forming vascular tubes were visualized. The volume of CNV vessels increased exponentially during the next 3 days. By 7 days, a well-defined isolectin-labeled CNV network was present, and its volume was preserved for several weeks. CNV volumes calculated on the basis of FITC-dextran perfusion were significantly lower than volumes obtained using lectin-labeled samples. A novel imaging technique was developed that allows a three-dimensional reconstruction and measurement of laser-induced CNV lesions in rat choroid/RPE flatmounts. This technique provides excellent morphologic detail and facilitates the study of critical early events in CNV, including the rupture of Bruch's membrane and the formation of endothelial clusters before vessel formation. CNV complexes are labeled at an earlier stage and more reproducibly than with FITC-dextran perfusion, providing a more accurate preclinical evaluation of antiangiogenic molecules. JF - Investigative ophthalmology & visual science AU - Campos, Mercedes AU - Amaral, Juan AU - Becerra, S Patricia AU - Fariss, Robert N AD - Biological Imaging Core, National Eye Institute, NIH, Bethesda, Maryland 20892-0703, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 5163 EP - 5170 VL - 47 IS - 12 SN - 0146-0404, 0146-0404 KW - Actins KW - 0 KW - Antigens, CD11b KW - Biomarkers KW - Dextrans KW - Fluorescent Dyes KW - Glycoproteins KW - Indoles KW - Lectins KW - fluorescein isothiocyanate dextran KW - isolectin B4-binding glycoprotein, rat KW - Phalloidine KW - 17466-45-4 KW - DAPI KW - 47165-04-8 KW - Fluorescein-5-isothiocyanate KW - I223NX31W9 KW - Index Medicus KW - Microscopy, Confocal KW - Animals KW - Fluorescein-5-isothiocyanate -- analogs & derivatives KW - Cell Nucleus -- pathology KW - Fluorescent Dyes -- metabolism KW - Endothelium, Vascular -- metabolism KW - Antigens, CD11b -- metabolism KW - Cell Nucleus -- metabolism KW - Pigment Epithelium of Eye -- metabolism KW - Actins -- metabolism KW - Rats, Inbred BN KW - Rats KW - Phalloidine -- metabolism KW - Glycoproteins -- metabolism KW - Endothelium, Vascular -- pathology KW - Indoles -- metabolism KW - Biomarkers -- metabolism KW - Pigment Epithelium of Eye -- pathology KW - Microglia -- pathology KW - Image Processing, Computer-Assisted KW - Male KW - Lectins -- metabolism KW - Microglia -- metabolism KW - Choroidal Neovascularization -- metabolism KW - Imaging, Three-Dimensional -- methods KW - Disease Models, Animal KW - Choroidal Neovascularization -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68182023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=A+novel+imaging+technique+for+experimental+choroidal+neovascularization.&rft.au=Campos%2C+Mercedes%3BAmaral%2C+Juan%3BBecerra%2C+S+Patricia%3BFariss%2C+Robert+N&rft.aulast=Campos&rft.aufirst=Mercedes&rft.date=2006-12-01&rft.volume=47&rft.issue=12&rft.spage=5163&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dose-ranging study of lutein supplementation in persons aged 60 years or older. AN - 68181673; 17122107 AB - To examine the dose-response relationship between oral lutein supplementation and serum lutein concentrations in persons aged 60 years and older, with or without age-related macular degeneration (AMD). Forty-five participants with no AMD, large drusen, or advanced AMD, were randomized to receive one of three doses (2.5, 5, or 10 mg) of lutein for 6 months and to be observed for 6 additional months after the cessation of lutein supplementation. The mean age of the participants (33 women) was 71 years (range: 60-91). The serum lutein concentrations of each dose group were similar before supplementation, increased at 1 month, and peaked by 3 months. Median serum concentrations of the 2.5-, 5-, and 10-mg groups from baseline to month 6 increased from 18.7 to 35.1 microg/dL (2-fold increase), from 17.8 to 59.2 microg/dL (2.9-fold increase), and from 15.1 to 66.8 microg/dL (4-fold increase), respectively (all P < 0.001). The increases in lutein serum concentrations did not vary with AMD disease severity (P = 0.98). No toxicity was observed with any dose of lutein. No significant changes were detected in visual acuity or visual field tests. Increasing doses of lutein supplements significantly increased the serum levels of lutein and zeaxanthin, and doses up to 10 mg were safely administered. A long-term large clinical trial is necessary to investigate the safety and efficacy of lutein in reducing the risk of the development of advanced AMD. JF - Investigative ophthalmology & visual science AU - Rosenthal, Julie M AU - Kim, Jonghyeon AU - de Monasterio, Francisco AU - de Monastario, Francisco AU - Thompson, Darby J S AU - Bone, Richard A AU - Landrum, John T AU - de Moura, Fabiana F AU - Khachik, Frederick AU - Chen, Huiping AU - Schleicher, Rosemary L AU - Ferris, Frederick L AU - Chew, Emily Y AD - Clinical Trials Branch, Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 5227 EP - 5233 VL - 47 IS - 12 SN - 0146-0404, 0146-0404 KW - Xanthophylls KW - 0 KW - Zeaxanthins KW - Lutein KW - X72A60C9MT KW - Index Medicus KW - Administration, Oral KW - Xanthophylls -- blood KW - Dose-Response Relationship, Drug KW - Humans KW - Aged KW - Pilot Projects KW - Feeding Behavior KW - Visual Fields KW - Chromatography, High Pressure Liquid KW - Aged, 80 and over KW - Dietary Supplements KW - Middle Aged KW - Visual Acuity KW - Female KW - Male KW - Lutein -- blood KW - Lutein -- administration & dosage KW - Macular Degeneration -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68181673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigative+ophthalmology+%26+visual+science&rft.atitle=Dose-ranging+study+of+lutein+supplementation+in+persons+aged+60+years+or+older.&rft.au=Rosenthal%2C+Julie+M%3BKim%2C+Jonghyeon%3Bde+Monasterio%2C+Francisco%3Bde+Monastario%2C+Francisco%3BThompson%2C+Darby+J+S%3BBone%2C+Richard+A%3BLandrum%2C+John+T%3Bde+Moura%2C+Fabiana+F%3BKhachik%2C+Frederick%3BChen%2C+Huiping%3BSchleicher%2C+Rosemary+L%3BFerris%2C+Frederick+L%3BChew%2C+Emily+Y&rft.aulast=Rosenthal&rft.aufirst=Julie&rft.date=2006-12-01&rft.volume=47&rft.issue=12&rft.spage=5227&rft.isbn=&rft.btitle=&rft.title=Investigative+ophthalmology+%26+visual+science&rft.issn=01460404&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Invest Ophthalmol Vis Sci. 2007 Jan;48(1):17 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol-related behaviors in serotonin transporter knockout mice. AN - 68167386; 17117959 AB - Increasing evidence supports a role for 5-hydroxytryptamine (5-HT) and the 5-HT transporter (5-HTT) in modulating the neural and behavioral actions of ethanol (EtOH) and other drugs of abuse. We used a 5-HTT knockout (KO) mouse model to further study this relationship. 5-Hydroxytryptamine transporter KO mice were tested for the sedative/hypnotic, hypothermia-inducing, motor-incoordinating (via accelerating rotarod), and depression-related (via tail suspension test) effects of acute EtOH administration. Reward-related effects of EtOH were assessed in 5-HTT KO mice using the conditioned place preference (CPP) paradigm. 5-Hydroxytryptamine transporter KO mice were tested for voluntary consumption of EtOH in a modified 2-bottle choice test that measured the temporal organization of drinking over the circadian cycle via "lickometers." Replicating previous findings, 5-HTT KO mice exhibited significantly increased sensitivity to EtOH-induced sedation/hypnosis relative to wild-type controls. Additionally, 5-HTT KO mice showed motor-coordination deficits at baseline and in response to EtOH. Hypothermic, pro-depressive-like, and reward-related effects of EtOH were no different across genotypes. Gross EtOH consumption was modestly reduced in 5-HTT KO mice, due to significantly lesser consumption during the peak period of drinking in the early dark phase. Data extend the finding that loss of 5-HTT gene function alters certain neural and behavioral effects of EtOH, with implications for better understanding the pathophysiology and treatment of alcoholism. JF - Alcoholism, clinical and experimental research AU - Boyce-Rustay, Janel M AU - Wiedholz, Lisa M AU - Millstein, Rachel A AU - Carroll, Jenna AU - Murphy, Dennis L AU - Daws, Lynette C AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA. janel.boyce-rustay@abbott.com Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1957 EP - 1965 VL - 30 IS - 12 SN - 0145-6008, 0145-6008 KW - Central Nervous System Depressants KW - 0 KW - Serotonin Plasma Membrane Transport Proteins KW - Slc6a4 protein, mouse KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Body Temperature -- drug effects KW - Dose-Response Relationship, Drug KW - Mice KW - Mice, Knockout KW - Sleep -- drug effects KW - Reward KW - Circadian Rhythm KW - Psychomotor Performance -- drug effects KW - Hypothermia -- chemically induced KW - Mice, Inbred C57BL KW - Motor Activity -- drug effects KW - Time Factors KW - Depression -- chemically induced KW - Behavior, Animal -- drug effects KW - Central Nervous System Depressants -- toxicity KW - Ethanol -- toxicity KW - Alcohol Drinking -- genetics KW - Serotonin Plasma Membrane Transport Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68167386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Alcoholism%2C+clinical+and+experimental+research&rft.atitle=Ethanol-related+behaviors+in+serotonin+transporter+knockout+mice.&rft.au=Boyce-Rustay%2C+Janel+M%3BWiedholz%2C+Lisa+M%3BMillstein%2C+Rachel+A%3BCarroll%2C+Jenna%3BMurphy%2C+Dennis+L%3BDaws%2C+Lynette+C%3BHolmes%2C+Andrew&rft.aulast=Boyce-Rustay&rft.aufirst=Janel&rft.date=2006-12-01&rft.volume=30&rft.issue=12&rft.spage=1957&rft.isbn=&rft.btitle=&rft.title=Alcoholism%2C+clinical+and+experimental+research&rft.issn=01456008&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-19 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dual dopamine-5-HT releasers: potential treatment agents for cocaine addiction. AN - 68164860; 17056126 AB - Biogenic amine transporters (BATs) are integral membrane proteins that translocate biogenic amine neurotransmitters [norepinephrine, dopamine (DA) and 5-hydroxytryptamine (5-HT)] across cell membranes. BATs are the principal sites of action for many psychotropic drugs, including abused stimulants such as cocaine and methamphetamine. Preclinical and human data demonstrate that withdrawal from long-term cocaine administration produces a dual deficit of synaptic DA and 5-HT in the brain, indicating the advantage of developing medications that normalize impairments in both neurotransmitter systems. In this article, we review data supporting the notion that stimulant effects normally produced by increased levels of extracellular DA can be antagonized by concurrent increases in levels of extracellular 5-HT. Accordingly, nonselective BAT substrates that can release both DA and 5-HT, such as the novel compound PAL287, have low abuse potential while maintaining the ability to suppress drug-seeking behavior. The collective findings indicate that such drugs will provide neurochemical normalization therapy for cocaine addiction and might also be useful for treating depression, obsessive-compulsive disorder, attention deficit disorder and obesity. JF - Trends in pharmacological sciences AU - Rothman, Richard B AU - Blough, Bruce E AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, PO Box 5180, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. rrothman@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 612 EP - 618 VL - 27 IS - 12 SN - 0165-6147, 0165-6147 KW - SLC6A4 protein, human KW - 0 KW - Serotonin Plasma Membrane Transport Proteins KW - Vesicular Biogenic Amine Transport Proteins KW - Serotonin KW - 333DO1RDJY KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Humans KW - Brain -- drug effects KW - Brain -- metabolism KW - Vesicular Biogenic Amine Transport Proteins -- physiology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Serotonin -- physiology KW - Dopamine -- deficiency KW - Vesicular Biogenic Amine Transport Proteins -- classification KW - Cocaine-Related Disorders -- drug therapy KW - Dopamine -- physiology KW - Dopamine -- metabolism KW - Serotonin -- metabolism KW - Vesicular Biogenic Amine Transport Proteins -- metabolism KW - Serotonin Plasma Membrane Transport Proteins -- physiology KW - Serotonin -- deficiency UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68164860?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+pharmacological+sciences&rft.atitle=Dual+dopamine-5-HT+releasers%3A+potential+treatment+agents+for+cocaine+addiction.&rft.au=Rothman%2C+Richard+B%3BBlough%2C+Bruce+E%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2006-12-01&rft.volume=27&rft.issue=12&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=Trends+in+pharmacological+sciences&rft.issn=01656147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic inhibition of HIV-1 envelope-mediated membrane fusion by inhibitors targeting the N and C-terminal heptad repeats of gp41. AN - 68163552; 17010381 AB - The human immunodeficiency virus type-1 (HIV-1) envelope (Env) proteins that mediate membrane fusion represent a major target for the development of new AIDS therapies. Three classes of Env-mediated membrane fusion inhibitors have been described that specifically target the pre-hairpin intermediate conformation of gp41. Class 2 inhibitors bind to the C-terminal heptad repeat (C-HR) of gp41. The single example of a class 3 inhibitor targets the trimeric N-terminal heptad repeat (N-HR) of gp41 and has been postulated to sequestrate the N-HR of the pre-hairpin intermediate through the formation of fusion incompetent heterotrimers. Here, we show that N(CCG)-gp41, a class 2 inhibitor, and N36(Mut(e,g)), a class 3 inhibitor, synergistically inhibit Env-mediated membrane fusion for several representative HIV-1 strains (X4 and R5) in both a cell fusion assay (with membrane-bound CD4) and an Env-pseudo-typed virus neutralization assay. The mechanistic, as well as potential therapeutic, implications of these observations for HIV-Env-mediated membrane fusion are discussed. JF - Journal of molecular biology AU - Gustchina, Elena AU - Louis, John M AU - Bewley, Carole A AU - Clore, G Marius AD - Laboratory of Chemical Physics, Building 5, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 283 EP - 289 VL - 364 IS - 3 SN - 0022-2836, 0022-2836 KW - HIV Envelope Protein gp41 KW - 0 KW - HIV Fusion Inhibitors KW - Peptides KW - Index Medicus KW - Animals KW - Amino Acid Motifs KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Drug Synergism KW - Cell Line KW - Protein Conformation KW - HIV-1 -- metabolism KW - Membrane Fusion KW - HIV Envelope Protein gp41 -- metabolism KW - Peptides -- chemistry KW - Peptides -- pharmacology KW - HIV Fusion Inhibitors -- pharmacology KW - HIV Envelope Protein gp41 -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68163552?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Synergistic+inhibition+of+HIV-1+envelope-mediated+membrane+fusion+by+inhibitors+targeting+the+N+and+C-terminal+heptad+repeats+of+gp41.&rft.au=Gustchina%2C+Elena%3BLouis%2C+John+M%3BBewley%2C+Carole+A%3BClore%2C+G+Marius&rft.aulast=Gustchina&rft.aufirst=Elena&rft.date=2006-12-01&rft.volume=364&rft.issue=3&rft.spage=283&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 2003 Feb 28;278(9):7573-9 [12486032] J Biol Chem. 2002 Apr 19;277(16):14238-45 [11859089] Biochemistry. 2004 Jun 29;43(25):8230-3 [15209519] J Mol Biol. 1982 Mar 15;155(4):447-66 [6283096] Adv Enzyme Regul. 1984;22:27-55 [6382953] J Virol. 1994 Sep;68(9):5411-22 [8057423] J Biol Chem. 1995 Oct 13;270(41):23883-6 [7592573] J Virol. 1996 Sep;70(9):6136-42 [8709238] Cell. 1997 Apr 18;89(2):263-73 [9108481] Nature. 1997 May 22;387(6631):426-30 [9163431] Curr Opin Immunol. 1997 Aug;9(4):551-62 [9287172] Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12303-8 [9356444] Nat Struct Biol. 1998 Apr;5(4):276-9 [9546217] Cell. 1998 May 29;93(5):681-4 [9630213] EMBO J. 1998 Aug 17;17(16):4572-84 [9707417] J Virol. 1999 Jul;73(7):6089-92 [10364363] J Med Chem. 2005 Apr 21;48(8):3036-44 [15828842] J Biol Chem. 2005 May 20;280(20):19852-7 [15772068] J Virol. 2005 Aug;79(16):10108-25 [16051804] Biochemistry. 2005 Sep 20;44(37):12471-9 [16156659] Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14759-64 [16203977] J Mol Biol. 2005 Nov 11;353(5):945-51 [16216270] J Virol. 2006 Feb;80(3):1414-26 [16415019] J Virol. 2000 Jan;74(1):326-33 [10590121] Science. 2001 Feb 2;291(5505):884-8 [11229405] J Biol Chem. 2001 Jan 12;276(2):1391-7 [11027678] J Am Chem Soc. 2001 May 2;123(17):3892-902 [11457139] J Biol Chem. 2001 Aug 3;276(31):29485-9 [11418583] Annu Rev Biochem. 2001;70:777-810 [11395423] J Biol Chem. 2003 May 30;278(22):20278-85 [12654905] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited commentary: disinfection by-products and pregnancy loss--lessons. AN - 68162558; 16957028 JF - American journal of epidemiology AU - Howards, Penelope P AU - Hertz-Picciotto, Irva AD - Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA. Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 1052 EP - 1055 VL - 164 IS - 11 SN - 0002-9262, 0002-9262 KW - Disinfectants KW - 0 KW - Hydrocarbons, Halogenated KW - Trihalomethanes KW - Water Pollutants, Chemical KW - Index Medicus KW - United States KW - Risk Factors KW - Humans KW - Adult KW - Environmental Exposure KW - Female KW - Pregnancy KW - Disinfectants -- adverse effects KW - Pregnancy Outcome -- epidemiology KW - Abortion, Spontaneous -- chemically induced KW - Water Pollutants, Chemical -- analysis KW - Water Pollutants, Chemical -- adverse effects KW - Hydrocarbons, Halogenated -- analysis KW - Water Supply KW - Trihalomethanes -- adverse effects KW - Abortion, Spontaneous -- epidemiology KW - Water Purification -- methods KW - Hydrocarbons, Halogenated -- adverse effects KW - Trihalomethanes -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68162558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+disinfection+by-products+and+pregnancy+loss--lessons.&rft.au=Howards%2C+Penelope+P%3BHertz-Picciotto%2C+Irva&rft.aulast=Howards&rft.aufirst=Penelope&rft.date=2006-12-01&rft.volume=164&rft.issue=11&rft.spage=1052&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-30 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2006 Dec 1;164(11):1043-51 [16957027] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic fluoxetine upregulates arachidonic acid incorporation into the brain of unanesthetized rats. AN - 68158882; 16517130 AB - Serotonergic 5-HT(2A/2C) receptors can be coupled to phospholipase A(2) (PLA(2)) activation to release the second messenger, arachidonic acid (AA), from membrane phospholipids. We wished to see if this signaling process in rat brain would be altered by chronic administration followed by 3days of washout of the selective serotonin reuptake inhibitor, fluoxetine. We injected [(3)H]AA intravenously in unanesthetized rats and used quantitative autoradiography to determine the incorporation coefficient k() for AA (regional brain radioactivity/integrated plasma radioactivity), a marker of PLA(2) activation, in each of 86 brain regions. k() was measured following acute i.p. saline or (+/-)-2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI, 1.0mg/kg i.p.), a 5-HT(2A/2C) receptor agonist, in rats injected for 21days with 10mg/kg i.p. fluoxetine or saline daily, followed by 3days without injection. Acute DOI produced statistically significant increments in k() in brain regions with high densities of 5-HT(2A/2C) receptors, but the increments did not differ significantly between the chronic fluoxetine- and saline-treated rats. Additionally, chronic fluoxetine compared with saline widely and significantly increased baseline values of k(). These results suggest that 5-HT(2A/2C) receptor-initiated AA signaling is unaffected by chronic fluoxetine plus 3days of washout in the rat, but that baseline AA signaling is nevertheless upregulated. This upregulation likely occurs independently of significant active drug in brain, considering the short brain half-lives of it and its norfluoxetine metabolite. Such upregulation may contribute to fluoxetine's efficacy against human depression. JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology AU - Qu, Ying AU - Chang, Lisa AU - Klaff, Justin AU - Seemann, Ruth AU - Greenstein, Deanna AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, Building 9, Room 1S128, National Institute on Aging, National Institutes of Health, 9 Memorial Drive, Bethesda, MD 20892, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 561 EP - 571 VL - 16 IS - 8 SN - 0924-977X, 0924-977X KW - Amphetamines KW - 0 KW - Serotonin Receptor Agonists KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Tritium KW - 10028-17-8 KW - Arachidonic Acid KW - 27YG812J1I KW - 4-iodo-2,5-dimethoxyphenylisopropylamine KW - OOM10GW9UE KW - Index Medicus KW - Tritium -- pharmacokinetics KW - Serotonin Receptor Agonists -- pharmacology KW - Animals KW - Drug Administration Schedule KW - Drug Interactions KW - Autoradiography KW - Drug Administration Routes KW - Rats KW - Brain Mapping KW - Rats, Inbred F344 KW - Amphetamines -- pharmacology KW - Wakefulness KW - Male KW - Infusions, Intravenous -- methods KW - Serotonin Uptake Inhibitors -- administration & dosage KW - Fluoxetine -- administration & dosage KW - Brain -- drug effects KW - Arachidonic Acid -- pharmacokinetics KW - Up-Regulation -- drug effects KW - Brain -- metabolism KW - Arachidonic Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68158882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.atitle=Chronic+fluoxetine+upregulates+arachidonic+acid+incorporation+into+the+brain+of+unanesthetized+rats.&rft.au=Qu%2C+Ying%3BChang%2C+Lisa%3BKlaff%2C+Justin%3BSeemann%2C+Ruth%3BGreenstein%2C+Deanna%3BRapoport%2C+Stanley+I&rft.aulast=Qu&rft.aufirst=Ying&rft.date=2006-12-01&rft.volume=16&rft.issue=8&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=European+neuropsychopharmacology+%3A+the+journal+of+the+European+College+of+Neuropsychopharmacology&rft.issn=0924977X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - DRD2 genetic variation in relation to smoking and obesity in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. AN - 68156046; 17108814 AB - Cigarette smoking is the leading cause of morbidity and mortality worldwide. We investigated the association between smoking behavior and genetic variations in the D2 dopamine receptor (DRD2), which mediates nicotine dependence. To assess the specificity of genetic effects, we also investigated other reward-motivated characteristics (obesity, alcohol consumption). Four single nucleotide polymorphisms in DRD2 were genotyped in 2374 participants selected randomly from the screening arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial after stratifying by sex, age, and smoking status. Smoking, obesity, and alcohol consumption were assessed by questionnaire. Single nucleotide polymorphism and haplotype associations were estimated using odds ratios (ORs) and 95% confidence intervals derived from conditional logistic regression models, adjusted for race/ethnicity. DRD2 polymorphisms were associated with the risk of remaining a current smoker and obesity. Current smokers were more likely than former smokers to possess the variant TaqIA allele (rsmusical sharp1800497) in a dose-dependent model (ORCT=1.2, ORTT=1.5, P for linear trend=0.007). The DRD2 haplotype T-C-T-A [TaqIA(C/T)-957(T/C)-IVS6-83(G/T)- -50977(A/G)] was more common among current than former smokers (OR=1.3, P=0.006), particularly among heavy smokers (21+ cigarettes per day; OR=1.6, P=0.006), and was more common among obese than normal weight individuals (OR=1.4, P=0.02). Genetic variation in DRD2 is a modifier of the reward-motivated characteristics, smoking and obesity. As fewer than 15% of smokers who attempt to quit are able to maintain abstinence for greater than 3 months, our results support that DRD2 is an appropriate molecular target for smoking cessation treatments. Our results further support evaluation of DRD2 antagonists for obesity therapies. JF - Pharmacogenetics and genomics AU - Morton, Lindsay M AU - Wang, Sophia S AU - Bergen, Andrew W AU - Chatterjee, Nilanjan AU - Kvale, Paul AU - Welch, Robert AU - Yeager, Meredith AU - Hayes, Richard B AU - Chanock, Stephen J AU - Caporaso, Neil E AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20852, USA. mortonli@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 901 EP - 910 VL - 16 IS - 12 SN - 1744-6872, 1744-6872 KW - Receptors, Dopamine D2 KW - 0 KW - Index Medicus KW - Genetic Variation KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Body Mass Index KW - Haplotypes KW - Reward KW - Tobacco Use Disorder -- genetics KW - Smoking Cessation KW - Alcohol Drinking -- psychology KW - Tobacco Use Disorder -- psychology KW - Middle Aged KW - Alcohol Drinking -- genetics KW - Female KW - Male KW - Obesity -- genetics KW - Obesity -- psychology KW - Smoking -- psychology KW - Receptors, Dopamine D2 -- genetics KW - Smoking -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68156046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=DRD2+genetic+variation+in+relation+to+smoking+and+obesity+in+the+Prostate%2C+Lung%2C+Colorectal%2C+and+Ovarian+Cancer+Screening+Trial.&rft.au=Morton%2C+Lindsay+M%3BWang%2C+Sophia+S%3BBergen%2C+Andrew+W%3BChatterjee%2C+Nilanjan%3BKvale%2C+Paul%3BWelch%2C+Robert%3BYeager%2C+Meredith%3BHayes%2C+Richard+B%3BChanock%2C+Stephen+J%3BCaporaso%2C+Neil+E&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2006-12-01&rft.volume=16&rft.issue=12&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-31 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - An in vitro model of human dopaminergic neurons derived from embryonic stem cells: MPP+ toxicity and GDNF neuroprotection. AN - 68154224; 17109014 AB - Human embryonic stem cells (hESCs) can proliferate indefinitely yet also differentiate in vitro, allowing normal human neurons to be generated in unlimited numbers. Here, we describe the development of an in vitro neurotoxicity assay using human dopaminergic neurons derived from hESCs. We showed that the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium (MPP(+)), which produces features of Parkinson's disease in humans, was toxic for hESC-derived dopaminergic neurons. Treatment with glial cell line-derived neurotrophic factor protected tyrosine hydroxylase-positive neurons against MPP(+)-induced apoptotic cell death and loss of neuronal processes as well as against the formation of intracellular reactive oxygen species. The availability of human dopaminergic neurons, derived from hESCs, therefore allows for the possibility of directly examining the unique features of human dopaminergic neurons with respect to their responses to pharmacological agents as well as environmental and chemical toxins. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Zeng, Xianmin AU - Chen, Jia AU - Deng, Xiaolin AU - Liu, Ying AU - Rao, Mahendra S AU - Cadet, Jean-Lud AU - Freed, William J AD - Intramural Research Program (IRP), Cellular Neurobiology Research Branch, Department of Health and Human Services (DHHS), National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH), Baltimore, MD, USA. xzeng@buckinstitute.org Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2708 EP - 2715 VL - 31 IS - 12 SN - 0893-133X, 0893-133X KW - Glial Cell Line-Derived Neurotrophic Factor KW - 0 KW - Neuroprotective Agents KW - Neurotoxins KW - Reactive Oxygen Species KW - 1-Methyl-4-phenylpyridinium KW - R865A5OY8J KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Reactive Oxygen Species -- metabolism KW - Animals KW - MPTP Poisoning -- drug therapy KW - Apoptosis -- physiology KW - Humans KW - Substantia Nigra -- drug effects KW - Dopamine -- metabolism KW - Mice KW - Cytoprotection -- drug effects KW - Neurotoxins -- toxicity KW - Neurotoxins -- antagonists & inhibitors KW - Neuroprotective Agents -- pharmacology KW - MPTP Poisoning -- physiopathology KW - Substantia Nigra -- metabolism KW - Substantia Nigra -- physiopathology KW - Oxidative Stress -- physiology KW - MPTP Poisoning -- metabolism KW - Apoptosis -- drug effects KW - Oxidative Stress -- drug effects KW - Toxicology -- methods KW - Neuroprotective Agents -- therapeutic use KW - Cell Line KW - Cytoprotection -- physiology KW - Glial Cell Line-Derived Neurotrophic Factor -- pharmacology KW - Embryonic Stem Cells -- metabolism KW - Embryonic Stem Cells -- drug effects KW - Neurons -- metabolism KW - 1-Methyl-4-phenylpyridinium -- toxicity KW - Neurons -- drug effects KW - Colony-Forming Units Assay -- methods KW - 1-Methyl-4-phenylpyridinium -- antagonists & inhibitors KW - Models, Biological KW - Glial Cell Line-Derived Neurotrophic Factor -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68154224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=An+in+vitro+model+of+human+dopaminergic+neurons+derived+from+embryonic+stem+cells%3A+MPP%2B+toxicity+and+GDNF+neuroprotection.&rft.au=Zeng%2C+Xianmin%3BChen%2C+Jia%3BDeng%2C+Xiaolin%3BLiu%2C+Ying%3BRao%2C+Mahendra+S%3BCadet%2C+Jean-Lud%3BFreed%2C+William+J&rft.aulast=Zeng&rft.aufirst=Xianmin&rft.date=2006-12-01&rft.volume=31&rft.issue=12&rft.spage=2708&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Neurosci. 2000 Dec;3(12):1301-6 [11100151] J Neurosci. 2000 Dec 15;20(24):9207-14 [11124998] Brain Res. 2001 Jun 15;904(1):67-75 [11516412] J Neurosci. 2001 Oct 15;21(20):8108-18 [11588183] Brain Res Dev Brain Res. 2002 Jan 31;133(1):27-35 [11850061] Neurotoxicology. 2002 Oct;23(4-5):487-502 [12428721] Mov Disord. 2003 Feb;18(2):121-9 [12539204] Neurosci Res. 2003 Jul;46(3):349-58 [12804796] Lancet Neurol. 2003 Sep;2(9):531-8 [12941575] Brain Res Dev Brain Res. 2003 Oct 10;145(1):107-15 [14519498] Stem Cells. 2003;21(6):647-53 [14595124] Neurosci Lett. 2004 May 6;361(1-3):52-5 [15135891] Stem Cells. 2004;22(3):292-312 [15153607] Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12543-8 [15310843] Stem Cells. 2004;22(5):669-74 [15342931] FASEB J. 2004 Oct;18(13):1618-20 [15319363] Cancer Res. 1973 Nov;33(11):2643-52 [4748425] Proc Natl Acad Sci U S A. 1976 Jul;73(7):2424-8 [1065897] Psychiatry Res. 1979 Dec;1(3):249-54 [298352] Science. 1983 Feb 25;219(4587):979-80 [6823561] Proc Natl Acad Sci U S A. 1983 Jul;80(14):4546-50 [6192438] Life Sci. 1985 Jan 21;36(3):219-24 [3871242] J Neurochem. 1986 Dec;47(6):1849-56 [3772380] Proc Natl Acad Sci U S A. 1987 May;84(10):3521-5 [3495000] Nature. 1987 May 28-Jun 3;327(6120):324-6 [2884568] J Neurochem. 1987 Sep;49(3):856-64 [2886556] Proc Natl Acad Sci U S A. 1987 Aug;84(16):5995-9 [3497401] Life Sci. 1988;42(23):2359-63 [3259663] Science. 1993 May 21;260(5111):1130-2 [8493557] J Neural Transm Gen Sect. 1993;93(1):75-82 [8373557] J Pharmacol Exp Ther. 1994 Sep;270(3):1008-14 [7932148] Nature. 1995 Jan 26;373(6512):335-9 [7830766] Cell Tissue Res. 1997 Aug;289(2):207-10 [9211823] J Pharmacol Exp Ther. 1997 Sep;282(3):1396-401 [9316852] Adv Pharmacol. 1998;42:911-5 [9328046] Neurochem Int. 1998 Feb;32(2):117-31 [9542724] Brain Res Mol Brain Res. 1998 May;56(1-2):84-8 [9602072] Science. 1998 Nov 6;282(5391):1145-7 [9804556] J Neurosci. 1999 Jan 1;19(1):10-20 [9870933] Brain Res. 1999 Jan 9;815(2):317-25 [9878807] JAMA. 1999 Jan 27;281(4):341-6 [9929087] Front Biosci. 2003 Sep 1;8:s826-37 [12957870] Stem Cells. 2004;22(6):925-40 [15536184] Stem Cells Dev. 2004 Dec;13(6):585-97 [15684826] Biomaterials. 2005 Oct;26(28):5746-54 [15878380] Stem Cells. 2005 Jun-Jul;23(6):781-90 [15917474] Stem Cells Dev. 2005 Oct;14(5):517-34 [16305337] Neurosci Res. 1999 Nov;35(2):135-44 [10616917] J Pharmacol Exp Ther. 2000 May;293(2):329-35 [10772999] J Neurosci. 2000 May 1;20(9):3182-90 [10777782] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. AN - 68149852; 16452993 AB - The goal of the present study was to develop and validate an animal model of unlimited access to intravenous heroin self-administration combined with responding for food and water to characterize the transition to drug dependence. Male Wistar rats were allowed to lever press for heroin (60 microg/kg/0.1 ml infusion/s; fixed ratio 1; 20-s time out) and nosepoke for food and water in consecutive, daily 23-h sessions. Daily heroin intake increased over days, reaching significance by Day 14. Drug-taking increased across the circadian cycle, reflected as increases in both the nocturnal peak and diurnal nadir of heroin intake. Changes in the circadian pattern of food intake and meal patterning preceded and paralleled the changes in heroin intake. By Day 7, the circadian amplitude of feeding was blunted. Nocturnal intake decreased because rats consumed smaller and briefer meals. Diurnal intake increased due to increased meal frequency, whereas total daily food intake decreased. To control for time or experience in the self-administration boxes as a possible confound, rats with saline (no drug) tethers were tested and did not display significant changes in food intake pattern. Body weight gain slowed slightly in heroin rats relative to saline controls. Separate groups of rats revealed that significant physical dependence as measured by physical signs of opiate withdrawal following a naloxone injection (1.0 mg/kg, subcutaneous (s.c.)) was reached by Day 14. Significant increases in heroin intake could be produced using low doses of naloxone (0.003-0.03 mg/kg, s.c.) on days 28-31 of heroin access. After 6 weeks of heroin self-administration, rats injected with buprenorphine (0, 0.01, 0.04, and 0.2 mg/kg, s.c.) showed a dose-dependent reduction in heroin intake. Changes in the pattern of drug and food intake in the present unlimited heroin access model may serve as independent motivational markers for the transition to a drug-dependent state. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Chen, Scott A AU - O'Dell, Laura E AU - Hoefer, Michael E AU - Greenwell, Thomas N AU - Zorrilla, Eric P AU - Koob, George F AD - Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA, USA. scott.chen@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 2692 EP - 2707 VL - 31 IS - 12 SN - 0893-133X, 0893-133X KW - Analgesics, Opioid KW - 0 KW - Biomarkers KW - Narcotic Antagonists KW - Narcotics KW - Buprenorphine KW - 40D3SCR4GZ KW - Heroin KW - 70D95007SX KW - Index Medicus KW - Eating -- drug effects KW - Eating -- physiology KW - Animals KW - Substance Withdrawal Syndrome -- physiopathology KW - Injections, Intravenous KW - Feeding Behavior -- physiology KW - Dose-Response Relationship, Drug KW - Buprenorphine -- pharmacology KW - Circadian Rhythm -- drug effects KW - Body Weight -- physiology KW - Narcotics -- adverse effects KW - Disease Models, Animal KW - Drug Interactions -- physiology KW - Rats KW - Self Administration KW - Circadian Rhythm -- physiology KW - Analgesics, Opioid -- pharmacology KW - Biomarkers -- analysis KW - Body Weight -- drug effects KW - Rats, Wistar KW - Narcotic Antagonists -- pharmacology KW - Feeding Behavior -- drug effects KW - Male KW - Opioid-Related Disorders -- diagnosis KW - Brain -- physiopathology KW - Opioid-Related Disorders -- physiopathology KW - Heroin -- adverse effects KW - Motivation KW - Brain -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68149852?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Unlimited+access+to+heroin+self-administration%3A+independent+motivational+markers+of+opiate+dependence.&rft.au=Chen%2C+Scott+A%3BO%27Dell%2C+Laura+E%3BHoefer%2C+Michael+E%3BGreenwell%2C+Thomas+N%3BZorrilla%2C+Eric+P%3BKoob%2C+George+F&rft.aulast=Chen&rft.aufirst=Scott&rft.date=2006-12-01&rft.volume=31&rft.issue=12&rft.spage=2692&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Neuropsychopharmacology. 2006 Dec;31(12):2802 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Venlafaxine-induced ecchymoses and impaired platelet aggregation. AN - 68149364; 16978240 AB - To describe a case of venlafaxine-induced ecchymoses. A patient with a history of ecchymoses coincident with venlafaxine therapy was rechallenged with the drug. Her platelet function was assessed with aggregation and ATP release studies before the rechallenge and after she developed ecchymoses. In addition, the effect of venlafaxine on platelet aggregation and ATP release was studied in vitro by adding the drug to platelet-rich plasma from normal donors. After 4 wk of treatment with venlafaxine our patient developed extensive ecchymoses. At that time her platelet aggregation and release responses to epinephrine, ADP, collagen, and arachidonic acid were markedly suppressed. Adding venlafaxine to normal platelet-rich plasma also dramatically reduced the aggregation and release responses to the same agonists as well as to serotonin, but the concentrations of venlafaxine required were 1000-fold greater than those normally achieved clinically. Our patient demonstrated an idiosyncratic hypersensitivity to the platelet inhibitory effects of venlafaxine. Because venlafaxine is an inhibitor of serotonin uptake by platelets and neurons, this mechanism may contribute to the impact of this drug on platelet function. However, our in vitro studies suggest that this hypothesis is inadequate to explain the observations completely. JF - European journal of haematology AU - Sarma, Anita AU - Horne, McDonald K AD - Hematology Service, Department of Laboratory Medicine, W. G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 533 EP - 537 VL - 77 IS - 6 SN - 0902-4441, 0902-4441 KW - Cyclohexanols KW - 0 KW - Serotonin Uptake Inhibitors KW - Arachidonic Acid KW - 27YG812J1I KW - Serotonin KW - 333DO1RDJY KW - Venlafaxine Hydrochloride KW - 7D7RX5A8MO KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Collagen KW - 9007-34-5 KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Collagen -- metabolism KW - Humans KW - Epinephrine -- pharmacology KW - Arachidonic Acid -- pharmacology KW - Adult KW - Adenosine Triphosphate -- metabolism KW - Collagen -- pharmacology KW - Serotonin -- metabolism KW - Time Factors KW - Female KW - Ecchymosis -- chemically induced KW - Cyclohexanols -- pharmacology KW - Serotonin Uptake Inhibitors -- pharmacology KW - Cyclohexanols -- adverse effects KW - Platelet Aggregation -- drug effects KW - Serotonin Uptake Inhibitors -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68149364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+haematology&rft.atitle=Venlafaxine-induced+ecchymoses+and+impaired+platelet+aggregation.&rft.au=Sarma%2C+Anita%3BHorne%2C+McDonald+K&rft.aulast=Sarma&rft.aufirst=Anita&rft.date=2006-12-01&rft.volume=77&rft.issue=6&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=European+journal+of+haematology&rft.issn=09024441&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemotherapy in neoplastic meningitis. AN - 68145504; 16949298 AB - Neoplastic meningitis (NM) is the result of the diffuse or multifocal localization of cancer cells in the cerebral spinal fluid (CSF). NM is more often a late complication of solid tumor or lymphoproliferative malignancies. At present, the goal of therapeutic strategies is palliative and the evaluation of high or low risk is important in identifying which patients could benefit from aggressive treatments such as radiation therapy and chemotherapy. Given that NM is a cancer complication that can spread throughout the entire subarachnoid space, chemotherapy, whether intrathecal or systemic, is currently considered the best treatment option, but optimal treatment is still controversial. This review summarizes intrathecal and systemic chemotherapeutic options in the treatment of NM and the related toxicities. JF - Critical reviews in oncology/hematology AU - Pace, Andrea AU - Fabi, Alessandra AD - Regina Elena National Cancer Institute, Rome, Italy. pace@ifo.it Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 194 EP - 200 VL - 60 IS - 3 SN - 1040-8428, 1040-8428 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Humans KW - Neoplasms -- drug therapy KW - Neoplasms -- complications KW - Neoplasms -- cerebrospinal fluid KW - Meningitis -- physiopathology KW - Meningitis -- complications KW - Meningitis -- cerebrospinal fluid KW - Antineoplastic Agents -- therapeutic use KW - Meningitis -- drug therapy KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68145504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Critical+reviews+in+oncology%2Fhematology&rft.atitle=Chemotherapy+in+neoplastic+meningitis.&rft.au=Pace%2C+Andrea%3BFabi%2C+Alessandra&rft.aulast=Pace&rft.aufirst=Andrea&rft.date=2006-12-01&rft.volume=60&rft.issue=3&rft.spage=194&rft.isbn=&rft.btitle=&rft.title=Critical+reviews+in+oncology%2Fhematology&rft.issn=10408428&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-23 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inhibition of spontaneous mutagenesis by vanillin and cinnamaldehyde in Escherichia coli: Dependence on recombinational repair. AN - 68138195; 16999979 AB - Vanillin (VAN) and cinnamaldehyde (CIN) are dietary antimutagens that effectively inhibit both induced and spontaneous mutations. We have shown previously that VAN and CIN reduced the spontaneous mutant frequency in Salmonella TA104 (hisG428, rfa, DeltauvrB, pKM101) by approximately 50% and that both compounds significantly reduced mutations at GC sites but not at AT sites. Previous studies have suggested that VAN and CIN may reduce mutations in bacterial model systems by modulating DNA repair pathways, particularly by enhancing recombinational repair. To further explore the basis for inhibition of spontaneous mutation by VAN and CIN, we have determined the effects of these compounds on survival and mutant frequency in five Escherichia coli strains derived from the wild-type strain NR9102 with different DNA repair backgrounds. At nontoxic doses, both VAN and CIN significantly reduced mutant frequency in the wild-type strain NR9102, in the nucleotide excision repair-deficient strain NR11634 (uvrB), and in the recombination-proficient but SOS-deficient strain NR11475 (recA430). In contrast, in the recombination-deficient and SOS-deficient strain NR11317 (recA56), both VAN and CIN not only failed to inhibit the spontaneous mutant frequency but actually increased the mutant frequency. In the mismatch repair-defective strain NR9319 (mutL), only CIN was antimutagenic. Our results show that the antimutagenicity of VAN and CIN against spontaneous mutation required the RecA recombination function but was independent of the SOS and nucleotide excision repair pathways. Thus, we propose the counterintuitive notion that these antimutagens actually produce a type of DNA damage that elicits recombinational repair (but not mismatch, SOS, or nucleotide excision repair), which then repairs not only the damage induced by VAN and CIN but also other DNA damage-resulting in an antimutagenic effect on spontaneous mutation. JF - Mutation research AU - Shaughnessy, Daniel T AU - Schaaper, Roel M AU - Umbach, David M AU - DeMarini, David M AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Research Triangle Park, NC 27709, USA. Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 54 EP - 64 VL - 602 IS - 1-2 SN - 0027-5107, 0027-5107 KW - Antimutagenic Agents KW - 0 KW - Benzaldehydes KW - Acrolein KW - 7864XYD3JJ KW - vanillin KW - CHI530446X KW - cinnamic aldehyde KW - SR60A3XG0F KW - Index Medicus KW - SOS Response (Genetics) KW - Dose-Response Relationship, Drug KW - Acrolein -- pharmacology KW - Escherichia coli -- metabolism KW - Antimutagenic Agents -- pharmacology KW - Acrolein -- analogs & derivatives KW - Recombination, Genetic -- drug effects KW - Escherichia coli -- drug effects KW - Escherichia coli -- genetics KW - Benzaldehydes -- pharmacology KW - DNA Repair -- drug effects KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68138195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Inhibition+of+spontaneous+mutagenesis+by+vanillin+and+cinnamaldehyde+in+Escherichia+coli%3A+Dependence+on+recombinational+repair.&rft.au=Shaughnessy%2C+Daniel+T%3BSchaaper%2C+Roel+M%3BUmbach%2C+David+M%3BDeMarini%2C+David+M&rft.aulast=Shaughnessy&rft.aufirst=Daniel&rft.date=2006-12-01&rft.volume=602&rft.issue=1-2&rft.spage=54&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2006-11-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mutat Res. 2000 Jul 10;468(2):93-108 [10882888] Environ Mol Mutagen. 2004;44(5):394-400 [15515154] Mutat Res. 2000 Sep 20;469(2):207-14 [10984681] J Food Prot. 2001 Mar;64(3):379-84 [11252483] Mutat Res. 2001 Sep 1;480-481:55-69 [11506799] Mutat Res. 2001 Oct 18;497(1-2):185-97 [11525922] Mutat Res. 2001 Nov 1;483(1-2):1-11 [11600126] Redox Rep. 2002;7(1):35-40 [11981453] Cancer Lett. 2003 Jul 10;196(2):143-52 [12860272] Mutagenesis. 2003 Sep;18(5):465-70 [12960416] Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12871-6 [14566050] Mutagenesis. 2004 May;19(3):169-85 [15123782] J Bacteriol. 1982 Oct;152(1):351-6 [6288664] Mutat Res. 1983 May;113(3-4):173-215 [6341825] Mutat Res. 1983 Feb;107(2):219-27 [6408465] Mol Gen Genet. 1983;192(3):309-15 [6419019] Gene. 1985;39(2-3):181-9 [4092929] Food Chem Toxicol. 1986 Jan;24(1):51-4 [3512393] J Mol Biol. 1986 May 20;189(2):273-84 [3018259] Basic Life Sci. 1986;39:181-96 [3533041] Mutat Res. 1987 Jan;187(1):11-9 [3540656] Mutat Res. 1988 Sep;201(1):107-12 [3047569] Contact Dermatitis. 1989 Mar;20(3):161-6 [2721181] Mutat Res. 1990 Feb;243(2):151-8 [2304483] Mutat Res. 1990 Mar;229(1):1-10 [2314406] Biochem Pharmacol. 1991 Aug 22;42(6):1177-9 [1653565] Genetics. 1991 Oct;129(2):317-26 [1660424] Mutat Res. 1992 Aug;268(2):231-7 [1379329] Crit Rev Toxicol. 1993;23(2):127-46 [8329113] Neuropharmacology. 1993 Jul;32(7):659-69 [7689708] J Biol Chem. 1993 Nov 15;268(32):23762-5 [8226906] Mutat Res. 1994 May 1;307(1):157-67 [7513793] Mutat Res. 1994 Jun;324(1-2):51-7 [7515470] Mutat Res. 1995 Jan;336(1):39-48 [7528894] Genetics. 1994 Oct;138(2):263-70 [7828810] Mutat Res. 1996 Oct 25;357(1-2):1-15 [8876675] Mutagenesis. 1997 Jul;12(4):297-303 [9237777] Genetics. 1998 Apr;148(4):1667-86 [9560386] Prog Nucleic Acid Res Mol Biol. 1999;63:311-66 [10506835] Mutat Res. 1999 Aug 18;444(2):355-65 [10521675] Mol Cell Biochem. 2000 Jun;209(1-2):47-53 [10942200] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Double-blind, placebo-controlled trial of selegiline transdermal system (STS) for the treatment of cocaine dependence. AN - 68112660; 16730924 AB - Cocaine dependence is a major public health problem for which there is no FDA-approved pharmacological treatment. Selegiline is an irreversible selective inhibitor of monoamine oxidase type B (MAO-B) which may affect cocaine addiction through several potential mechanisms. In this study, selegiline transdermal system (STS) was compared to placebo as a treatment for cocaine dependence. This multi-site, double-blind trial of 300 subjects with cocaine dependence assessed the efficacy of selegiline using subject self-reported cocaine use substantiated by urine benzoylecgonine (BE) as the primary outcome measure. Analysis of the data did not show a significant effect for selegiline over placebo. This study does not support a role for selegiline in treating cocaine dependence. The contrast of this result to earlier, promising preclinical and human pilot data could be due to factors associated with sample size, patient characteristics, dose, or poor predictive validity of preclinical models. JF - Drug and alcohol dependence AU - Elkashef, Ahmed AU - Fudala, Paul J AU - Gorgon, Liza AU - Li, Shou-Hua AU - Kahn, Roberta AU - Chiang, Nora AU - Vocci, Frank AU - Collins, Joseph AU - Jones, Karen AU - Boardman, Kathy AU - Sather, Mike AD - National Institute on Drug Abuse (NIDA), Division of Pharmacotherapies and Medical Consequences of Drug Abuse (DPMCDA), MSC 9551 Bethesda, MD 20892, USA. ae8a@nih.gov Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 191 EP - 197 VL - 85 IS - 3 SN - 0376-8716, 0376-8716 KW - Monoamine Oxidase Inhibitors KW - 0 KW - Selegiline KW - 2K1V7GP655 KW - Index Medicus KW - Administration, Cutaneous KW - Double-Blind Method KW - Humans KW - Adult KW - Male KW - Female KW - Drug Delivery Systems KW - Selegiline -- administration & dosage KW - Selegiline -- therapeutic use KW - Monoamine Oxidase Inhibitors -- administration & dosage KW - Cocaine-Related Disorders -- rehabilitation KW - Monoamine Oxidase Inhibitors -- therapeutic use KW - Cocaine-Related Disorders -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68112660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+alcohol+dependence&rft.atitle=Double-blind%2C+placebo-controlled+trial+of+selegiline+transdermal+system+%28STS%29+for+the+treatment+of+cocaine+dependence.&rft.au=Elkashef%2C+Ahmed%3BFudala%2C+Paul+J%3BGorgon%2C+Liza%3BLi%2C+Shou-Hua%3BKahn%2C+Roberta%3BChiang%2C+Nora%3BVocci%2C+Frank%3BCollins%2C+Joseph%3BJones%2C+Karen%3BBoardman%2C+Kathy%3BSather%2C+Mike&rft.aulast=Elkashef&rft.aufirst=Ahmed&rft.date=2006-12-01&rft.volume=85&rft.issue=3&rft.spage=191&rft.isbn=&rft.btitle=&rft.title=Drug+and+alcohol+dependence&rft.issn=03768716&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-27 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Weekly docetaxel as second line chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. AN - 68111472; 16919884 AB - Docetaxel has to be considered as the reference control arm for second line chemotherapy for advanced NSCLC. Weekly docetaxel has been compared to standard 3-weekly schedule in a randomized fashion to determine if such schedule improves survival and quality of life. We performed a literature-based meta-analysis of all randomized clinical trials (RCTs) comparing weekly over 3-weekly docetaxel in advanced NSCLC. All randomized trials were considered eligible. A literature-based meta-analysis was accomplished, and event-based relative risk ratios (RR) with 95% confidence interval (CI) were derived. A fixed- and a random-effect model according to the inverse variance and the Mantel-Haenszel method were applied. Heterogeneity test was applied as well. We found six RCTs (three phase III, two phase II, 1018 patients), in which data for overall survival (OS), overall response rate (ORR) and grade 3-4 (G3-4) WHO neutropenia were available. When considering only phase III RCTs, OS did not significantly differ between the two arms (RR 1.01, 95% CI 0.76, 1.42, p=0.785) with no significant heterogeneity (p=0.42). Regarding activity, no significant differences in favour of weekly docetaxel were found, although a trend for 3-weekly schedule was observed (RR 0.81, 95% CI 0.47, 1.40, p=0.485), with no significant heterogeneity (p=0.27). No differences were found in the overall population also considering the phase II trials. Regarding G3-4 neutropenia, a significant homogenous advantage in favour of weekly docetaxel was found, with an absolute benefit of 15-19%. Although considering all drawbacks related to literature-based meta-analyses, weekly docetaxel seems not to improve survival when compared to 3-weekly docetaxel. The significant benefit in grade 3-4 neutropenia seems to suggest this approach in patients with NSCLC pretreated for advanced disease. The quality of life of both schedules needs to be evaluated in an individual patient data meta-analysis. JF - Cancer treatment reviews AU - Bria, Emilio AU - Cuppone, Federica AU - Ciccarese, Mariangela AU - Nisticò, Cecilia AU - Facciolo, Francesco AU - Milella, Michele AU - Izzo, Fiorentino AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Giannarelli, Diana AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Roma, Italy. emiliobria@yahoo.com.it Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 583 EP - 587 VL - 32 IS - 8 SN - 0305-7372, 0305-7372 KW - Antineoplastic Agents, Phytogenic KW - 0 KW - Taxoids KW - docetaxel KW - 15H5577CQD KW - Index Medicus KW - Randomized Controlled Trials as Topic KW - Drug Administration Schedule KW - Neoplasm Staging KW - Infusions, Intravenous KW - Humans KW - Salvage Therapy KW - Neutropenia -- chemically induced KW - Survival Analysis KW - Carcinoma, Non-Small-Cell Lung -- mortality KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Antineoplastic Agents, Phytogenic -- therapeutic use KW - Lung Neoplasms -- drug therapy KW - Taxoids -- adverse effects KW - Lung Neoplasms -- mortality KW - Taxoids -- therapeutic use KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Antineoplastic Agents, Phytogenic -- administration & dosage KW - Taxoids -- administration & dosage KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68111472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reviews&rft.atitle=Weekly+docetaxel+as+second+line+chemotherapy+for+advanced+non-small-cell+lung+cancer%3A+meta-analysis+of+randomized+trials.&rft.au=Bria%2C+Emilio%3BCuppone%2C+Federica%3BCiccarese%2C+Mariangela%3BNistic%C3%B2%2C+Cecilia%3BFacciolo%2C+Francesco%3BMilella%2C+Michele%3BIzzo%2C+Fiorentino%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BGiannarelli%2C+Diana&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2006-12-01&rft.volume=32&rft.issue=8&rft.spage=583&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reviews&rft.issn=03057372&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-21 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Religion and HIV Risk Behaviors Among Married Men: Initial Results from a Study in Rural Sub-Saharan Africa AN - 61640006; 200717171 AB - Although some scholars have identified religion as a possible protective factor in the AIDS pandemic in sub-Saharan Africa, evidence concerning the relationship between religion and AIDS behavior there remains sparse. Using a sample of married men from rural Malawi, we examine whether AIDS risk behavior and perceived risk are associated with religious affiliation or with religious involvement. Our analyses of data from the Malawi Diffusion and Ideational Change Project (2001) reveal substantial variation according to religious affiliation and religious involvement. Men belonging to Pentecostal churches consistently report lower levels of both HIV risk behavior and perceived risk. Regular attendance at religious services is associated both with reduced odds of reporting extramarital partners and with lower levels of perceived risk of infection. Tables, Figures, References. Adapted from the source document. JF - Journal for the Scientific Study of Religion AU - Trinitapoli, Jenny AU - Regnerus, Mark D AD - Department of Sociology and an NICHD predoctoral trainee at the Population Research Center at the University of Texas at Austin, 1 University Station G1800, Austin, TX 78712-0118 Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 505 EP - 528 PB - Blackwell Publishers, Malden MA VL - 45 IS - 4 SN - 0021-8294, 0021-8294 KW - Husbands KW - Risk KW - Risk Factors KW - Sub Saharan Africa KW - Acquired Immune Deficiency Syndrome KW - Malawi KW - Church Attendance KW - Church Membership KW - article KW - 2045: sociology of health and medicine; sociology of medicine & health care KW - 1535: sociology of religion; sociology of religion UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61640006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:book&rft.genre=book&rft.jtitle=&rft.atitle=&rft.au=Avery%2C+Christopher%3BHoxby%2C+Caroline+M&rft.aulast=Avery&rft.aufirst=Christopher&rft.date=2004-01-01&rft.volume=&rft.issue=&rft.spage=239&rft.isbn=0226355357&rft.btitle=Do+and+Should+Financial+Aid+Packages+Affect+Students%27+College+Choices%3F&rft.title=Do+and+Should+Financial+Aid+Packages+Affect+Students%27+College+Choices%3F&rft.issn=&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-02 N1 - Last updated - 2016-09-28 N1 - CODEN - JSSRBT N1 - SubjectsTermNotLitGenreText - Acquired Immune Deficiency Syndrome; Risk; Church Membership; Husbands; Malawi; Sub Saharan Africa; Risk Factors; Church Attendance DO - http://dx.doi.org/10.1111/j.1468-5906.2006.00325.x ER - TY - JOUR T1 - A pilot project of a cancer patient library in Italy: results of a customer-satisfaction survey and its products. AN - 57643164; 00495582 AB - Aims: The purpose of this study is to determine the degree of satisfaction of users of the Cancer Information Point section of the Library for Patients (CIP-LP), active since 1998 at the National Cancer Institute of Aviano, Italy. The CIP-LP is based on a skilled intermediary, adequate informative material and a specific location, within the Scientific Library of the Institute. Patients and methods: A survey was developed to assess service functionality and quality from the users' viewpoint. During a 6-month period, a questionnaire was mailed to 194 patients and relatives who previously used the CIP-LP; 113 (58%) were returned and processed. Results: Of the respondents, 91% were pleased with the CIP-LP and 95% would recommend the service to other people. The information obtained contributed to a clearer understanding of the illness and treatment (45% as first answer) and a better control of the situation (33%). Fifty-one per cent evaluated the information received as 'good', 42% 'excellent' and 4% 'of sufficient quality'. Conclusion: This survey shows the appreciation and usefulness in the users' perception of a specific hospital library for cancer patients and their relatives, providing an information service supplementary to doctor-patient communication. (Author abstract) JF - Health Information and Libraries Journal AU - Truccolo, Ivana AU - Bianchet, Katia AU - Capello, Fabia AU - Russell-Edu, William AU - Dal Maso, Luigino AU - Colombatti, Alfonso AU - Ciolfi, Laura AU - Tirelli, Umberto AU - De Paoli, Paolo AD - Scientific Library, CRO Aviano National Cancer Institute, V. Pedemontana Occidentale, 12. 33081 Aviano (PN), Italy itruccolo@cro.it Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 266 EP - 274 PB - Blackwell Publishing Ltd VL - 23 IS - 4 SN - 1471-1834, 1471-1834 KW - Information services KW - Medical informatics KW - Patients KW - User satisfaction KW - Hospital libraries KW - Italy KW - Cancer KW - 4.13: USERS - SOCIAL GROUPS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57643164?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Information+and+Libraries+Journal&rft.atitle=A+pilot+project+of+a+cancer+patient+library+in+Italy%3A+results+of+a+customer-satisfaction+survey+and+its+products.&rft.au=Truccolo%2C+Ivana%3BBianchet%2C+Katia%3BCapello%2C+Fabia%3BRussell-Edu%2C+William%3BDal+Maso%2C+Luigino%3BColombatti%2C+Alfonso%3BCiolfi%2C+Laura%3BTirelli%2C+Umberto%3BDe+Paoli%2C+Paolo&rft.aulast=Truccolo&rft.aufirst=Ivana&rft.date=2006-12-01&rft.volume=23&rft.issue=4&rft.spage=266&rft.isbn=&rft.btitle=&rft.title=Health+Information+and+Libraries+Journal&rft.issn=14711834&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-05-28 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Hospital libraries; Information services; User satisfaction; Patients; Medical informatics; Cancer; Italy ER - TY - JOUR T1 - Depressive Symptomatology among HIV-Positive Women in the Era of HAART: A Stress and Coping Model AN - 57195412; 200714054 AB - Objective: An enhanced stress and coping model was used to explain depression among HIV-positive women in healthcare and community settings where highly active anti-retroviral treatment (HAART) was commonplace. Method: HIV-infected women in four cities (N = 978) were assessed, cross-sectionally, for mental and physical health, stress, social support, and other background factors. Results: Self-reported level of depressive symptomatology was high. Number of physical symptoms, illness intrusiveness, and perceived stress were positively associated with depressed mood, while coping self-efficacy and social support were negatively associated. Stress mediated the effect of health status on depression and coping self-efficacy mediated the effect of psychosocial resources on depression. Our enhanced stress and coping model accounted for 52% of variance in depressive symtpomatology. Conclusions: Interventions focused on improving coping self-efficacy, bolstering social supports, and decreasing stress in the lives of HIV-positive women may help to reduce the negative effects of HIV disease on mood. Tables, Figures, References. Adapted from the source document. JF - American Journal of Community Psychology AU - Remien, Robert H AU - Exner, Theresa AU - Kertzner, Robert M AU - Ehrhardt, Anke A AU - Rotheram-Borus, Mary Jane AU - Johnson, Mallory O AU - Weinhardt, Lance S AU - Kittel, Lauren E AU - Goldstein, Rise B AU - Pinto, Rogerio M AU - Morin, Stephen F AU - Chesney, Margaret A AU - Lightfoot, Marguerita AU - Gore-Felton, Cheryl AU - Dodge, Brian AU - Kelly, Jeffrey A AU - NIMH Health Living Project Trial Group AD - NIMH Healthy Living Project Group, HIV Center Clinical & Behavioral Studies, New York State Psychiatric Instit, NY Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 275 EP - 285 PB - Springer, Dordrecht The Netherlands VL - 38 IS - 3-4 SN - 0091-0562, 0091-0562 KW - HIV, Depression, Women, Coping, Stress, Health KW - Selfefficacy KW - Coping skills KW - Depression KW - Stress KW - Antiretroviral therapy KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57195412?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Community+Psychology&rft.atitle=Depressive+Symptomatology+among+HIV-Positive+Women+in+the+Era+of+HAART%3A+A+Stress+and+Coping+Model&rft.au=Remien%2C+Robert+H%3BExner%2C+Theresa%3BKertzner%2C+Robert+M%3BEhrhardt%2C+Anke+A%3BRotheram-Borus%2C+Mary+Jane%3BJohnson%2C+Mallory+O%3BWeinhardt%2C+Lance+S%3BKittel%2C+Lauren+E%3BGoldstein%2C+Rise+B%3BPinto%2C+Rogerio+M%3BMorin%2C+Stephen+F%3BChesney%2C+Margaret+A%3BLightfoot%2C+Marguerita%3BGore-Felton%2C+Cheryl%3BDodge%2C+Brian%3BKelly%2C+Jeffrey+A%3BNIMH+Health+Living+Project+Trial+Group&rft.aulast=Remien&rft.aufirst=Robert&rft.date=2006-12-01&rft.volume=38&rft.issue=3-4&rft.spage=275&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Community+Psychology&rft.issn=00910562&rft_id=info:doi/10.1007%2Fs10464-006-9083-y LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - AJCPCK N1 - SubjectsTermNotLitGenreText - Depression; HIV; Antiretroviral therapy; Stress; Coping skills; Selfefficacy DO - http://dx.doi.org/10.1007/s10464-006-9083-y ER - TY - JOUR T1 - DSM-IV Alcohol Dependence: a Categorical Or Dimensional Phenotype? AN - 57179474; 200711293 AB - Background. Etiologic research on complex disorders including alcohol dependence requires informative phenotypes. Information is lost when categorical variables represent inherently dimensional conditions. We investigated the validity of DSM-IV alcohol dependence as a dimensional phenotype by examining evidence for linearity and thresholds in associations with validating variables. Method. Current drinkers in the National Longitudinal Alcohol Epidemiologic Survey (NLAES) ('n'=18352) and National Epidemiologic Survey of Alcohol and Related Conditions (NESARC) ('n'=20836) were analyzed. Validating variables included family alcoholism, early-onset drinking, and alcohol treatment. Logistic or Poisson regression modeled the relationships between the validating variables and dependence in categorical, dimensional or hybrid forms, with severity defined as number of current DSM-IV alcohol-dependence criteria. Wald tests assessed differences between models. Results. No evidence was found for boundaries between categories. Instead, the association of alcohol dependence with the validating variables generally increased in linear fashion as the number of alcohol-dependence criteria increased. For NLAES models of family alcoholism, early-onset drinking and treatment, the lines had zero intercepts, with slopes of 0.18, 0.27, 0.70, respectively. For NESARC models of family history and early-onset drinking, the zero intercept lines had slopes of 0.20, 0.33, and 0.77, respectively. Wald tests indicated that models representing alcohol dependence as a dimensional linear predictor best described the association between dependence criteria and the validating variables. Conclusions. The sample sizes allowed strong tests. Diagnoses are necessary for clinical decision-making, but a dimensional alcohol-dependence indicator should provide more information for research purposes. (Published Online October 12 2006). Adapted from the source document. JF - Psychological Medicine AU - Hasin, Deborah S AU - Liu, Xinhua AU - Alderson, Donald AU - Grant, Bridget F AD - Department of Epidemiology, Mailman School of Public Health, and Department of Psychiatry, College of Physicians and Surgeons, Columbia University, NY, USA Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1695 EP - 1705 PB - Cambridge University Press, UK VL - 36 IS - 12 SN - 0033-2917, 0033-2917 KW - Clinical decision making KW - Alcohol consumption KW - Diagnostic and Statistical Manual IV KW - Alcohol dependence KW - Phenotypes KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57179474?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+Medicine&rft.atitle=DSM-IV+Alcohol+Dependence%3A+a+Categorical+Or+Dimensional+Phenotype%3F&rft.au=Hasin%2C+Deborah+S%3BLiu%2C+Xinhua%3BAlderson%2C+Donald%3BGrant%2C+Bridget+F&rft.aulast=Hasin&rft.aufirst=Deborah&rft.date=2006-12-01&rft.volume=36&rft.issue=12&rft.spage=1695&rft.isbn=&rft.btitle=&rft.title=Psychological+Medicine&rft.issn=00332917&rft_id=info:doi/10.1017%2FS0033291706009068 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-02 N1 - Last updated - 2016-09-27 N1 - CODEN - PSMDCO N1 - SubjectsTermNotLitGenreText - Alcohol consumption; Alcohol dependence; Diagnostic and Statistical Manual IV; Phenotypes; Clinical decision making DO - http://dx.doi.org/10.1017/S0033291706009068 ER - TY - JOUR T1 - Functioning and Quality of Life in the Treatment for Adolescents with Depression Study (TADS) AN - 57161686; 200710385 AB - Objective: To test whether 12-week treatment of major depression improved the level of functioning, global health, & quality of life of adolescents. Method: The Treatment for Adolescents With Depression Study was a multisite, randomized clinical trial of fluoxetine, cognitive-behavioral therapy (CBT), their combination (COMB), or clinical management with placebo in 439 adolescents with major depression. Functioning was measured with the Children's Global Assessment Scale (CGAS), global health with the Health of the Nation Outcome Scales for Children & Adolescents (HoNOSCA), & quality of life with the Pediatric Quality of Life Enjoyment & Satisfaction Questionnaire (PQ-LES-Q). Random-effects regression models were applied to the data. Results: Compared with placebo, COMB was effective on the CGAS (p < .0001), HoNOSCA (p < .05), & PQ-LES-Q (p < .001), whereas fluoxetine was superior to placebo on the CGAS only (p < .05). COMB was superior to fluoxetine on the CGAS (p < .05) & PQ-LES-Q (p = .001). Fluoxetine was superior to CBT on the CGAS (p < .01). CBT monotherapy was not statistically different from the placebo group on any of the measures assessed. Treatment effects were mediated by improvement in depressive symptoms measured on the Child Depression Rating Scale -- Revised. Conclusions: The combination of fluoxetine & CBT was effective in improving functioning, global health, & quality of life in depressed adolescents. Fluoxetine monotherapy improved functioning. Tables, Figures, References. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Vitiello, Benedetto AU - Rohde, Paul AU - Silva, Susan AU - Wells, Karen AU - Casat, Charles AU - Waslick, Bruce AU - Simons, Anne AU - Reinecke, Mark AU - Weller, Elizabeth AU - Kratochvil, Christopher AU - Walkup, John AU - Pathak, Sanjeev AU - Robins, Michele AU - March, John AU - Team, TADS AD - NIMH, Bethesda, MD Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 1419 EP - 1426 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 45 IS - 12 SN - 0890-8567, 0890-8567 KW - depression, treatment, functioning, impairment KW - Depression KW - Outcomes KW - Treatment KW - Adolescents KW - Quality of life KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57161686?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Functioning+and+Quality+of+Life+in+the+Treatment+for+Adolescents+with+Depression+Study+%28TADS%29&rft.au=Vitiello%2C+Benedetto%3BRohde%2C+Paul%3BSilva%2C+Susan%3BWells%2C+Karen%3BCasat%2C+Charles%3BWaslick%2C+Bruce%3BSimons%2C+Anne%3BReinecke%2C+Mark%3BWeller%2C+Elizabeth%3BKratochvil%2C+Christopher%3BWalkup%2C+John%3BPathak%2C+Sanjeev%3BRobins%2C+Michele%3BMarch%2C+John%3BTeam%2C+TADS&rft.aulast=Vitiello&rft.aufirst=Benedetto&rft.date=2006-12-01&rft.volume=45&rft.issue=12&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2F01.chi.0000242229.52646.6e LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Quality of life; Depression; Treatment; Outcomes; Adolescents DO - http://dx.doi.org/10.1097/01.chi.0000242229.52646.6e ER - TY - JOUR T1 - Examining the Origins of Gender Differences in Marital Quality: A Behavior Genetic Analysis AN - 57156652; 200706858 AB - Numerous researchers have examined gender differences in marital quality, with mixed results. In this study, the authors further this investigation by looking for genetic and environmental sources of variation in marital quality. The 1st aim of the study was to replicate previous findings of genetic and nonshared environmental influences on marital quality. The 2nd was to explore the etiology of gender differences in marital quality. The Virginia Adult Twin Study of Psychiatric and Substance Use Disorders sample of twin men and twin women was used. Genetic and nonshared environmental factors were again found to influence marital quality. Findings also suggest small differences between men and women in the levels of genetic and environmental influence on variance in marital quality. The men's reports of marital warmth and conflict were influenced by the same genetic factors, but women's reports of marital warmth and conflict were influenced by different genetic factors. Results are discussed in the context of previous research on social support and implications for future studies of the etiology of marital quality. [Copyright 2006 Elsevier Ltd.] JF - Journal of Environmental Psychology AU - Spotts, Erica L AU - Prescott, Carol AU - Kendler, Kenneth AD - Center for Family Research, George Washington University spottse@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 605 EP - 613 VL - 20 IS - 4 SN - 0272-4944, 0272-4944 KW - marital quality, gender differences, genetics, nonshared environment KW - Behaviour genetics KW - Gender differences KW - Marital quality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57156652?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+Computer+Review&rft.atitle=Old+Wine+in+a+New+Wineskin%3A+College+Choice%2C+College+Access+Using+Agent-Based+Modeling&rft.au=Henrickson%2C+Leslie&rft.aulast=Henrickson&rft.aufirst=Leslie&rft.date=2002-01-01&rft.volume=20&rft.issue=4&rft.spage=400&rft.isbn=&rft.btitle=&rft.title=Social+Science+Computer+Review&rft.issn=08944393&rft_id=info:doi/10.1177%2F089443902237319 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JEPSEO N1 - SubjectsTermNotLitGenreText - Marital quality; Gender differences; Behaviour genetics DO - http://dx.doi.org/10.1037/0893-3200.20.4.605 ER - TY - JOUR T1 - Evolution of the Colored Eco-Genetic Relationship Map (CEGRM) for Assessing Social Functioning in Women in Hereditary Breast-Ovarian (HBOC) Families AN - 57119718; 200708147 AB - The CEGRM was initially conceived as a simple, concise, visual representation of the social interaction domains of information, tangible services and emotional exchanges (Kenen, R., & Peters, J. (2001). J Genet Counsel, 10, 289-309). A blend of the genetic pedigree, genogram, and ecomap, the CEGRM was developed to facilitate contemporary genetic counseling goals. An exploratory pilot study of 20 subjects showed that it was feasible, comfortable and efficiently accomplished, and that the process was useful both for assessment and as an intervention with study participants (Peters, J. A., Kenen, R., Giusti, R., Loud, J., Weissman, N., & Greene, M. H. (2004). Am J Med Genet Part A, 130A, 258-264). Subsequently, we have extended the CEGRM to 150 women from hereditary breast/ovarian cancer (HBOC) families; three different investigators have successfully administered this tool. The preliminary findings from the exploratory study were confirmed in the larger sample. Engaging in the interactive, insight-promoting CEGRM process provides a novel tool for assessing the social context of genetic testing, and helping high-risk women better understand and integrate genetic information into their personal and family identities, health beliefs, and decisions. Adapted from the source document. JF - Journal of Genetic Counseling AU - Peters, June A AU - Hoskins, Lindsey AU - Prindiville, Sheila AU - Kenen, Regina AU - Greene, Mark H AD - Department of Health and Human Services (DHHS), 6120 Executive Blvd. #EPS 7026, Rockville, MD. E-mail: petersju@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 477 EP - 489 PB - Springer Science+Business Media, New York NY VL - 15 IS - 6 SN - 1059-7700, 1059-7700 KW - genetic counseling KW - breast cancer genetics KW - genetic testing KW - family KW - friends KW - relationships KW - kin KW - social network KW - communications KW - pedigree KW - genogram KW - ecomap KW - psychosocial KW - psychological KW - social KW - familial cancer KW - hereditary cancer KW - Ovarian cancer KW - Genetic screening KW - Breast cancer KW - Social interaction KW - Genetic family histories KW - Genetic counselling KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57119718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Genetic+Counseling&rft.atitle=Evolution+of+the+Colored+Eco-Genetic+Relationship+Map+%28CEGRM%29+for+Assessing+Social+Functioning+in+Women+in+Hereditary+Breast-Ovarian+%28HBOC%29+Families&rft.au=Peters%2C+June+A%3BHoskins%2C+Lindsey%3BPrindiville%2C+Sheila%3BKenen%2C+Regina%3BGreene%2C+Mark+H&rft.aulast=Peters&rft.aufirst=June&rft.date=2006-12-01&rft.volume=15&rft.issue=6&rft.spage=477&rft.isbn=&rft.btitle=&rft.title=Journal+of+Genetic+Counseling&rft.issn=10597700&rft_id=info:doi/10.1007%2Fs10897-006-9042-7 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JGCOET N1 - SubjectsTermNotLitGenreText - Genetic counselling; Breast cancer; Genetic screening; Genetic family histories; Ovarian cancer; Social interaction DO - http://dx.doi.org/10.1007/s10897-006-9042-7 ER - TY - JOUR T1 - Heroin and cocaine craving and use during treatment: Measurement validation and potential relationships AN - 57078562; 200720703 AB - Although commonly assessed with unidimensional scales, craving has been suggested to be multifaceted and to have a complex relationship with drug use and relapse. This study assessed the consistency and predictive validity of unidimensional and multidimensional craving scales. At the beginning of a 12-week outpatient treatment trial, opiate users (n = 101) and cocaine users (n = 72) completed unidimensional visual analog scales (VASs) assessing 'want,' 'need,' and 'craving' and multidimensional 14- and 45-item versions of the Cocaine Craving Questionnaire (CCQ) or Heroin Craving Questionnaire (HCQ). Spearman correlations between the VASs and the first-order factors from the 45-item CCQ/HCQ were .20-.40, suggesting that the two types of assessment were not redundant. Treatment dropout and in-treatment drug use were more frequently predicted by scores on the 14- or 45-item CCQ than by VAS ratings. Results suggest that the CCQ/HCQ and the 14-item CCQ provide information that unidimensional VASs do not. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Heinz, Adrienne J AU - Epstein, David H AU - Schroeder, Jennifer R AU - Singleton, Edward G AU - Heishman, Stephen J AU - Preston, Kenzie L AD - Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA email: heinza@intra.nida.nih.gov Y1 - 2006/12// PY - 2006 DA - December 2006 SP - 355 EP - 364 PB - Elsevier, New York NY VL - 31 IS - 4 SN - 0740-5472, 0740-5472 KW - Craving KW - Cocaine KW - Heroin KW - Treatment KW - Measure KW - Relapse KW - Substance Abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57078562?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Heroin+and+cocaine+craving+and+use+during+treatment%3A+Measurement+validation+and+potential+relationships&rft.au=Heinz%2C+Adrienne+J%3BEpstein%2C+David+H%3BSchroeder%2C+Jennifer+R%3BSingleton%2C+Edward+G%3BHeishman%2C+Stephen+J%3BPreston%2C+Kenzie+L&rft.aulast=Heinz&rft.aufirst=Adrienne&rft.date=2006-12-01&rft.volume=31&rft.issue=4&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.05.009 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-12-10 N1 - Last updated - 2016-09-27 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Substance Abuse; Heroin; Cocaine; Treatment; Craving; Relapse DO - http://dx.doi.org/10.1016/j.jsat.2006.05.009 ER - TY - JOUR T1 - The development of children's ideal and ought self-guides: parenting, temperament, and individual differences in guide strength AN - 36662890; 3426477 AB - Regulatory focus theory (RFT; Higgins, 1997) predicts that individual differences in the strength of promotion (ideal) and prevention (ought) orientations emerge from patterns of parent/child interactions that emphasize making good things happen versus keeping bad things from happening. This article examines the development of individual differences in the strength of children's promotion and prevention goals and presents selected findings from three studies exploring the origins of regulatory focus. We found a three-factor structure for parenting behaviors that differentiated between the presence/absence of positive outcomes versus the presence/absence of negative outcomes in two different data sets and validated that factor structure by examining its associations with maternal temperament. In turn, the parenting factors predicted individual differences in children's orientations to ideal and ought guides, and those associations were moderated by individual differences in child temperament. Reprinted by permission of Blackwell Publishers JF - Journal of personality AU - Manian, Nanmathi AU - Papadakis, Alison A AU - Strauman, Timothy J AU - Essex, Marilyn J AD - National Institute of Child Health and Human Development ; Duke University ; University of Wisconsin Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1619 EP - 1646 VL - 74 IS - 6 SN - 0022-3506, 0022-3506 KW - Sociology KW - Psychology KW - Parenting KW - Behavioural psychology KW - Parent-child relations KW - Personality KW - Child development KW - Adaptation to change UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36662890?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=The+development+of+children%27s+ideal+and+ought+self-guides%3A+parenting%2C+temperament%2C+and+individual+differences+in+guide+strength&rft.au=Manian%2C+Nanmathi%3BPapadakis%2C+Alison+A%3BStrauman%2C+Timothy+J%3BEssex%2C+Marilyn+J&rft.aulast=Manian&rft.aufirst=Nanmathi&rft.date=2006-12-01&rft.volume=74&rft.issue=6&rft.spage=1619&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/10.1111%2Fj.1467-6494.2006.00422.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9416 2153; 2197 2212 6075 3483; 9183; 9178 4777 6093 6823; 1540 1543 10404; 559; 10404 DO - http://dx.doi.org/10.1111/j.1467-6494.2006.00422.x ER - TY - JOUR T1 - Personality and self-regulation AN - 36660217; 3426744 JF - Journal of personality AU - Hoyle, Rick H AU - Morf, Carolyn C AU - Ryan, Richard M AU - Deci, Edward L AU - Kochanska, Grazyna AU - Aksan, Nazan AU - Manian, Nanmathi AU - Papadakis, Alison A AU - Strauman, Timothy J AU - Essex, Marilyn J AU - Brazy, Paige C AU - Shah, James Y AU - Sherrill, Michelle R AU - Sansone, Carol AU - Thoman, Dustin B AU - Rasmussen, Heather N AU - Wrosch, Carsten AU - Scheier, Michael F AU - Carver, Charles S AU - Crocker, Jennifer AU - Brook, Amara T AU - Niiya, Yu AU - Villacorta, Mark AU - Baumeister, Roy F AU - Gailliot, Matthew AU - DeWall, C Nathan AU - Oaten, Megan AU - Leary, Mark R AU - Adams, Claire E AU - Tate, Eleanor B AD - Universität Bern ; University of Rochester ; University of Iowa ; National Institute of Child Health and Human Development ; Duke University ; University of Wisconsin ; University of Utah ; University of Pittsburgh ; Concordia University ; Carnegie Mellon University ; University of Miami ; University of Michigan ; Florida State University ; MacQuarie University ; Louisiana State University Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1507 EP - 1831 VL - 74 IS - 6 SN - 0022-3506, 0022-3506 KW - Sociology KW - Emotions KW - Human nature KW - Motivation KW - Psychology KW - Parent-child relations KW - Social interaction KW - Self-determination KW - Autonomy KW - Optimism KW - Child development KW - Cultural studies KW - Cognition KW - Family studies KW - Information KW - Consciousness KW - Parenting KW - Personality traits KW - Mental health KW - Social environment KW - Interpersonal relations KW - Human behaviour KW - Self-esteem UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36660217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+personality&rft.atitle=Personality+and+self-regulation&rft.au=Hoyle%2C+Rick+H%3BMorf%2C+Carolyn+C%3BRyan%2C+Richard+M%3BDeci%2C+Edward+L%3BKochanska%2C+Grazyna%3BAksan%2C+Nazan%3BManian%2C+Nanmathi%3BPapadakis%2C+Alison+A%3BStrauman%2C+Timothy+J%3BEssex%2C+Marilyn+J%3BBrazy%2C+Paige+C%3BShah%2C+James+Y%3BSherrill%2C+Michelle+R%3BSansone%2C+Carol%3BThoman%2C+Dustin+B%3BRasmussen%2C+Heather+N%3BWrosch%2C+Carsten%3BScheier%2C+Michael+F%3BCarver%2C+Charles+S%3BCrocker%2C+Jennifer%3BBrook%2C+Amara+T%3BNiiya%2C+Yu%3BVillacorta%2C+Mark%3BBaumeister%2C+Roy+F%3BGailliot%2C+Matthew%3BDeWall%2C+C+Nathan%3BOaten%2C+Megan%3BLeary%2C+Mark+R%3BAdams%2C+Claire+E%3BTate%2C+Eleanor+B&rft.aulast=Hoyle&rft.aufirst=Rick&rft.date=2006-12-01&rft.volume=74&rft.issue=6&rft.spage=1507&rft.isbn=&rft.btitle=&rft.title=Journal+of+personality&rft.issn=00223506&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 12 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 9429 9416 2153; 6515; 10404; 6071 1542 11325; 11829 6077 4309; 8322; 2449 10404; 6823; 1425 2119 2116 5551 7506 5586 9792; 11470; 4196; 2724; 9178 4777 6093 6823; 4783; 9183; 2197 2212 6075 3483; 11860 11907; 7947 5772 7954; 8965; 11473 11442 6191; 6085; 3185 ER - TY - JOUR T1 - Analysis of Human Phagocyte Flavocytochrome b sub(558) by Mass Spectrometry AN - 21345786; 7193134 AB - The catalytic core of the phagocyte NADPH oxidase is a heterodimeric integral membrane protein (flavocytochrome b (Cyt b)) that generates superoxide and initiates a cascade of reactive oxygen species critical for the host inflammatory response. In order to facilitate structural characterization, the present study reports the first direct analysis of human phagocyte Cyt b by matrix-assisted laser desorption/ionization and nanoelectrospray mass spectrometry. Mass analysis of in-gel tryptic digest samples provided 73% total sequence coverage of the gp91 super(phox) subunit, including three of the six proposed transmembrane domains. Similar analysis of the p22 super(phox) subunit provided 72% total sequence coverage, including assignment of the hydrophobic N-terminal region and residues that are polymorphic in the human population. To initiate mass analysis of Cyt b post-translational modifications, the isolated gp91 super(phox) subunit was subject to sequential in-gel digestion with Flavobacterium meningosepticum peptide N-glycosidase F and trypsin, with matrix-assisted laser desorption/ionization and liquid chromatography-mass spectrometry/mass spectrometry used to demonstrate that Asn-132, -149, and -240 are genuinely modified by N-linked glycans in human neutrophils. Since the PLB-985 cell line represents an important model system for analysis of the NADPH oxidase, methods were developed for the purification of Cyt b from PLB-985 membrane fractions in order to confirm the appropriate modification of N-linked glycosylation sites on the recombinant gp91 super(phox) subunit. This study reports extensive sequence coverage of the integral membrane protein Cyt b by mass spectrometry and provides analytical methods that will be useful for evaluating posttranslational modifications involved in the regulation of superoxide production. JF - Journal of Biological Chemistry AU - Taylor, Ross M AU - Baniulis, Danas AU - Burritt, James B AU - Gripentrog, Jeannie M AU - Lord, Connie I AU - Riesselman, Marcia H AU - Maaty, Walid S AU - Bothner, Brian P AU - Angel, Thomas E AU - Dratz, Edward A AU - Linton, Gilda F AU - Malech, Harry L AU - Jesaitis, Algirdas J AD - Departments of Microbiology and Chemistry and Biochemistry, Montana State University, Bozeman, Montana 59717 and the Laboratory of Host Defenses, NIAID, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 37045 EP - 37056 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 48 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology KW - Trypsin KW - Flavobacterium meningosepticum KW - Leukocytes (neutrophilic) KW - N-glycosidase KW - Hydrophobicity KW - Membrane proteins KW - Glycosylation KW - Transmembrane domains KW - Mass spectroscopy KW - Inflammation KW - N-linked glycans KW - Post-translation KW - Reactive oxygen species KW - Phagocytes KW - Superoxide KW - NAD(P)H oxidase KW - Lasers KW - Ionization KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21345786?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Analysis+of+Human+Phagocyte+Flavocytochrome+b+sub%28558%29+by+Mass+Spectrometry&rft.au=Taylor%2C+Ross+M%3BBaniulis%2C+Danas%3BBurritt%2C+James+B%3BGripentrog%2C+Jeannie+M%3BLord%2C+Connie+I%3BRiesselman%2C+Marcia+H%3BMaaty%2C+Walid+S%3BBothner%2C+Brian+P%3BAngel%2C+Thomas+E%3BDratz%2C+Edward+A%3BLinton%2C+Gilda+F%3BMalech%2C+Harry+L%3BJesaitis%2C+Algirdas+J&rft.aulast=Taylor&rft.aufirst=Ross&rft.date=2006-12-01&rft.volume=281&rft.issue=48&rft.spage=37045&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-02-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Trypsin; Leukocytes (neutrophilic); N-glycosidase; Hydrophobicity; Glycosylation; Membrane proteins; Transmembrane domains; Mass spectroscopy; Inflammation; Reactive oxygen species; Post-translation; N-linked glycans; Phagocytes; Superoxide; Lasers; NAD(P)H oxidase; Ionization; Flavobacterium meningosepticum ER - TY - JOUR T1 - The Analysis of Stratified 2 X 2 Contingency Tables AN - 21102180; 11132911 AB - We consider the problem of testing for independence against the consistent superiority of one treatment over another when the response variable is binary and is compared across two treatments in each of several strata. Specifically, we consider the randomized clinical trial setting. A number of issues arise in this context. First, should tables be combined if there are small or zero margins? Second, should one assume a common odds ratio across strata? Third, if the odds ratios differ across strata, then how does the standard test (based on a common odds ratio) perform? Fourth, are there other analyzes that are more appropriate for handling a situation in which the odds ratios may differ across strata? In addressing these issues we find that the frequently used Cochran-Mantel-Haenszel test may have a poor power profile, despite being optimal when the odds ratios are common. We develop novel tests that are analogous to the Smirnov, modified Smirnov, convex hull, and adaptive tests that have been proposed for ordered categorical data. JF - Biometrical Journal AU - Berger, Vance W AU - Stefanescu, Catalina AU - Zhou, Yan Yan AD - University of Maryland Baltimore County and National Cancer Institute, Executive Plaza North, Suite 3131, Bethesda, MD 20892-7354, USA, cstefanescu@london.edu Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 992 EP - 1007 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 6 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Clinical trials KW - Contingency KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21102180?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=The+Analysis+of+Stratified+2+X+2+Contingency+Tables&rft.au=Berger%2C+Vance+W%3BStefanescu%2C+Catalina%3BZhou%2C+Yan+Yan&rft.aulast=Berger&rft.aufirst=Vance&rft.date=2006-12-01&rft.volume=48&rft.issue=6&rft.spage=992&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610277 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Data processing; Clinical trials; Contingency DO - http://dx.doi.org/10.1002/bimj.200610277 ER - TY - JOUR T1 - Non-inferiority of New Procedure to Standard Procedure in Stratified Matched-Pair Design AN - 21089563; 11132908 AB - We consider the statistical testing for non-inferiority of a new treatment compared with the standard one under matched-pair setting in a stratified study or in several trials. A non-inferiority test based on the efficient scores and a Mantel-Haenszel (M-H) like procedure with restricted maximum likelihood estimators (RMLEs) of nuisance parameters and their corresponding sample size formulae are presented. We evaluate the above tests and the M-H type Wald test in level and power. The stratified score test is conservative and provides the best power. The M-H like procedure with RMLEs gives an accurate level. However, the Wald test is anti-conservative and we suggest caution when it is used. The unstratified score test is not biased but it is less powerful than the stratified score test when base-line probabilities related to strata are not the same. This investigation shows that the stratified score test possesses optimum statistical properties in testing non-inferiority. A common difference between two proportions across strata is the basic assumption of the stratified tests, we present appropriate tests to validate the assumption and related remarks. JF - Biometrical Journal AU - Nam, Jun-mo AD - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health & Human Services, Executive Plaza South, Room 8028, 6120 Executive Boulevard, MSC 7240, Rockville, Maryland 20892-7240, USA, namj@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 966 EP - 977 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 6 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21089563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Non-inferiority+of+New+Procedure+to+Standard+Procedure+in+Stratified+Matched-Pair+Design&rft.au=Nam%2C+Jun-mo&rft.aulast=Nam&rft.aufirst=Jun-mo&rft.date=2006-12-01&rft.volume=48&rft.issue=6&rft.spage=966&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200510283 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Statistics DO - http://dx.doi.org/10.1002/bimj.200510283 ER - TY - JOUR T1 - Clustering of Helicobacter pylori VacA in Lipid Rafts, Mediated by Its Receptor, Receptor-Like Protein Tyrosine Phosphatase {beta}, Is Required for Intoxication in AZ-521 Cells AN - 20988908; 7192744 AB - Helicobacter pylori vacuolating cytotoxin, VacA, induces multiple effects on epithelial cells through different cellular events: one involves pore formation, leading to vacuolation, mitochondrial damage, and apoptosis, and the second involves cell signaling, resulting in stimulation of proinflammatory responses and cell detachment. Our recent data demonstrated that VacA uses receptor-like protein tyrosine phosphatase {beta} (RPTP{beta}) as a receptor, of which five residues (QTTQP) at positions 747 to 751 are involved in binding. In AZ-521 cells, which mainly express RPTP{beta}, VacA, after binding to RPTP{beta} in non-lipid raft microdomains on the cell surface, is localized with RPTP{beta} in lipid rafts in a temperature- and VacA concentration-dependent process. Methyl-{beta}-cyclodextrin (MCD) did not block binding to RPTP{beta} but inhibited translocation of VacA with RPTP{beta} to lipid rafts and all subsequent events. On the other hand, 5-nitro-2-(3-phenylpropylamino)-benzoic acid (NPPB), which disrupts anion channels, did not inhibit translocation of VacA to lipid rafts or VacA-induced activation of p38 mitogen-activated protein (MAP) kinase, but inhibited VacA internalization followed by vacuolation. Thus, p38 MAP kinase activation did not appear to be required for internalization. In contrast, phosphatidylinositol-specific phospholipase C (PI-PLC) inhibited translocation, as well as p38 MAP kinase/ATF-2 activation, internalization, and VacA-induced vacuolation. Neither NPPB nor PI-PLC affected VacA binding to cells and to its receptor, RPTP{beta}. Thus, receptor-dependent translocation of VacA to lipid rafts is critical for signaling pathways leading to p38 MAP kinase/ATF-2 activation and vacuolation. JF - Infection and Immunity AU - Nakayama, Masaaki AU - Hisatsune, Jyunzo AU - Yamasaki, Eiki AU - Nishi, Yoshito AU - Wada, Akihiro AU - Kurazono, Hisao AU - Sap, Jan AU - Yahiro, Kinnosuke AU - Moss, Joel AU - Hirayama, Toshiya AD - Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan. Laboratory of Veterinary Public Health, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Sakai, Osaka 599-8531. Department of Molecular Pathology, University of Copenhagen, Copenhagen DK-2100, Denmark. Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1590 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 6571 EP - 6580 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Intoxication KW - Helicobacter pylori KW - Cell surface KW - Protein transport KW - Epithelial cells KW - MAP kinase KW - Apoptosis KW - Data processing KW - Channel pores KW - Cytotoxins KW - Activating transcription factor 2 KW - Phospholipase C KW - Mitochondria KW - Inflammation KW - Protein-tyrosine-phosphatase KW - Lipid rafts KW - Anion channels KW - Translocation KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20988908?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Clustering+of+Helicobacter+pylori+VacA+in+Lipid+Rafts%2C+Mediated+by+Its+Receptor%2C+Receptor-Like+Protein+Tyrosine+Phosphatase+%7Bbeta%7D%2C+Is+Required+for+Intoxication+in+AZ-521+Cells&rft.au=Nakayama%2C+Masaaki%3BHisatsune%2C+Jyunzo%3BYamasaki%2C+Eiki%3BNishi%2C+Yoshito%3BWada%2C+Akihiro%3BKurazono%2C+Hisao%3BSap%2C+Jan%3BYahiro%2C+Kinnosuke%3BMoss%2C+Joel%3BHirayama%2C+Toshiya&rft.aulast=Nakayama&rft.aufirst=Masaaki&rft.date=2006-12-01&rft.volume=74&rft.issue=12&rft.spage=6571&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Intoxication; Epithelial cells; Protein transport; Cell surface; MAP kinase; Data processing; Apoptosis; Channel pores; Phospholipase C; Activating transcription factor 2; Cytotoxins; Mitochondria; Lipid rafts; Protein-tyrosine-phosphatase; Inflammation; Anion channels; Translocation; Signal transduction; Helicobacter pylori ER - TY - JOUR T1 - Identification of Potential Virulence Determinants by Himar1 Transposition of Infectious Borrelia burgdorferi B31 AN - 20977088; 7192756 AB - Lyme disease Borrelia organisms are highly invasive spirochetes that alternate between vertebrate and arthropod hosts and that establish chronic infections and elicit inflammatory reactions in mammals. Although progress has been made in the targeted mutagenesis of individual genes in infectious Borrelia burgdorferi, the roles of the vast majority of gene products in pathogenesis remain unresolved. In this study, we examined the feasibility of using transposon mutagenesis to identify infectivity-related factors in B. burgdorferi. The transformable, infectious strain 5A18 NP1 was transformed with the spirochete-adapted Himar1 transposon delivery vector pMarGent to create a small library of 33 insertion mutants. Single mouse inoculations followed by culture of four tissue sites and serology were used to screen the mutants for infectivity phenotypes. Mutants that appeared attenuated (culture positive at some sites) or noninfectious (negative at all sites) and contained the virulence-associated plasmids lp25 and lp28-1 were examined in more extensive animal studies. Three of these mutants (including those with insertions in the putative fliG-1-encoded flagellar motor switch protein and the guaB-encoded IMP dehydrogenase) were noninfectious, whereas four clones appeared to exhibit reduced infectivity. Serological reactivity in VlsE enzyme-linked immunosorbent assays correlated with the assignment of mutants to the noninfectious or attenuated-infectivity groups. The results of this study indicate that random transposon mutagenesis of infectious B. burgdorferi is feasible and will be of value in studying the pathogenesis of Lyme disease BORRELIA: JF - Infection and Immunity AU - Botkin, Douglas J AU - Abbott, April N AU - Stewart, Philip E AU - Rosa, Patricia A AU - Kawabata, Hiroki AU - Watanabe, Haruo AU - Norris, Steven J AD - Graduate School of Biomedical Sciences. Program in Microbiology and Molecular Genetics. Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at Houston, Houston, Texas 77030. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 6690 EP - 6699 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Enzyme-linked immunosorbent assay KW - IMP dehydrogenase KW - Borrelia burgdorferi KW - Transposition KW - Vectors KW - Tissue culture KW - Plasmids KW - Serology KW - Inflammation KW - Transposons KW - Virulence KW - Spirochetes KW - Infectivity KW - Arthropoda KW - transposon mutagenesis KW - Chronic infection KW - Inoculation KW - targeted mutagenesis KW - Flagella KW - Lyme disease KW - J 02400:Human Diseases KW - F 06910:Microorganisms & Parasites KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20977088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Identification+of+Potential+Virulence+Determinants+by+Himar1+Transposition+of+Infectious+Borrelia+burgdorferi+B31&rft.au=Botkin%2C+Douglas+J%3BAbbott%2C+April+N%3BStewart%2C+Philip+E%3BRosa%2C+Patricia+A%3BKawabata%2C+Hiroki%3BWatanabe%2C+Haruo%3BNorris%2C+Steven+J&rft.aulast=Botkin&rft.aufirst=Douglas&rft.date=2006-12-01&rft.volume=74&rft.issue=12&rft.spage=6690&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzyme-linked immunosorbent assay; IMP dehydrogenase; Transposition; Vectors; Tissue culture; Plasmids; Serology; Inflammation; Virulence; Transposons; Spirochetes; Infectivity; transposon mutagenesis; Chronic infection; Inoculation; targeted mutagenesis; Lyme disease; Flagella; Arthropoda; Borrelia burgdorferi ER - TY - JOUR T1 - Imaging of the lymphatic system: new horizons AN - 20811272; 10921614 AB - The lymphatic system is a complex network of lymph vessels, lymphatic organs and lymph nodes. Traditionally, imaging of the lymphatic system has been based on conventional imaging methods like computed tomography (CT) and magnetic resonance imaging (MRI), whereby enlargement of lymph nodes is considered the primary diagnostic criterion for disease. This is particularly true in oncology, where nodal enlargement can be indicative of nodal metastases or lymphoma. CT and MRI on their own are, however, anatomical imaging methods. Newer imaging methods such as positron emission tomography (PET), dynamic contrast-enhanced MRI (DCE-MRI) and color Doppler ultrasound (CDUS) provide a functional assessment of node status. None of these techniques is capable of detecting flow within the lymphatics and, thus, several intra-lymphatic imaging methods have been developed. Direct lymphangiography is an all-but-extinct method of visualizing the lymphatic drainage from an extremity using oil-based iodine contrast agents. More recently, interstitially injected intra-lymphatic imaging, such as lymphoscintigraphy, has been used for lymphedema assessment and sentinel node detection. Nevertheless, radionuclide-based imaging has the disadvantage of poor resolution. This has lead to the development of novel systemic and interstitial imaging techniques which are minimally invasive and have the potential to provide both structural and functional information; this is a particular advantage for cancer imaging, where anatomical depiction alone often provides insufficient information. At present the respective role each modality plays remains to be determined. Indeed, multi-modal imaging may be more appropriate for certain lymphatic disorders. The field of lymphatic imaging is ever evolving, and technological advances, combined with the development of new contrast agents, continue to improve diagnostic accuracy. Published in 2006 by John Wiley & Sons, Ltd. JF - Contrast Media and Molecular Imaging AU - Barrett, Tristan AU - Choyke, Peter L AU - Kobayashi, Hisataka AD - Molecular Imaging Program, National Cancer Institute, Building 10, Room 1B40, Bethesda, MD 20892-1088, USA, kobayash@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 230 EP - 245 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA, [mailto:info@wiley.com], [URL:http://www.wiley.com/WileyCDA/Brand/id-35.html] VL - 1 IS - 6 SN - 1555-4309, 1555-4309 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Invasiveness KW - Magnetic resonance imaging KW - Oncology KW - Lymphangiography KW - Metastases KW - Structure-function relationships KW - Positron emission tomography KW - Contrast media KW - Iodine KW - Ultrasound KW - Lymphoma KW - Lymphatic system KW - Doppler effect KW - Drainage KW - Lymph KW - Cancer KW - Lymph nodes KW - Color KW - Lymphedema KW - Computed tomography KW - W 30910:Imaging KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20811272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Contrast+Media+and+Molecular+Imaging&rft.atitle=Imaging+of+the+lymphatic+system%3A+new+horizons&rft.au=Barrett%2C+Tristan%3BChoyke%2C+Peter+L%3BKobayashi%2C+Hisataka&rft.aulast=Barrett&rft.aufirst=Tristan&rft.date=2006-12-01&rft.volume=1&rft.issue=6&rft.spage=230&rft.isbn=&rft.btitle=&rft.title=Contrast+Media+and+Molecular+Imaging&rft.issn=15554309&rft_id=info:doi/10.1002%2Fcmmi.116 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Contrast media; Computed tomography; Lymphatic system; Positron emission tomography; Lymph nodes; Lymph; Invasiveness; Drainage; Doppler effect; Lymphedema; Structure-function relationships; Cancer; Iodine; Lymphoma; Ultrasound; Lymphangiography; Oncology; Metastases; Color DO - http://dx.doi.org/10.1002/cmmi.116 ER - TY - JOUR T1 - Risk of Multiple Myeloma following Medication Use and Medical Conditions: A Case-Control Study in Connecticut Women AN - 20725445; 7206732 AB - Background: Certain commonly used drugs and medical conditions characterized by chronic immune dysfunction and/or antigen stimulation have been suggested to affect important pathways in multiple myeloma tumor cell growth and survival. We conducted a population-based case-control study to investigate the role of medical history in the etiology of multiple myeloma among Connecticut women. Methods: A total of 179 incident multiple myeloma cases (21-84 years, diagnosed 1996-2002) and 691 population-based controls was included in this study. Information on medical conditions, medications, and medical radiation was obtained by in-person interviews. We calculated odds ratios (OR) as measures of relative risks using logistic regression models. Results: A reduced multiple myeloma risk was found among women who had used antilipid statin therapy [OR, 0.4; 95% confidence interval (95% CI), 0.2-0.8] or estrogen replacement therapy (OR, 0.6; 95% CI, 0.4-0.99) or who had a medical history of allergy (OR, 0.4; 95% CI, 0.3-0.7), scarlet fever (OR, 0.5; 95% CI, 0.2-0.9), or bursitis (OR, 0.4; 95% CI, 0.2-0.7). An increased risk of multiple myeloma was found among women who used prednisone (OR, 5.1; 95% CI, 1.8-14.4), insulin (OR, 3.1; 95% CI, 1.1-9.0), or gout medication (OR, 6.7; 95% CI, 1.2-38.0). Conclusions: If our results are confirmed, mechanistic studies examining how prior use of insulin, prednisone, and, perhaps, gout medication might promote increased occurrence of multiple myeloma and how antilipid statins, estrogen replacement therapy, and certain medical conditions might protect against multiple myeloma may provide insights to the as yet unknown etiology of multiple myeloma. (Cancer Epidemiol Biomarkers Prev 2006; 15(12):2342-7) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Landgren, Ola AU - Zhang, Yawei AU - Zahm, Sheila Hoar AU - Inskip, Peter AU - Zheng, Tongzhang AU - Baris, Dalsu AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland and Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2342 EP - 2347 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 12 SN - 1055-9965, 1055-9965 KW - Risk Abstracts KW - Bioindicators KW - Historical account KW - Etiology KW - USA, Connecticut KW - multiple myeloma KW - insulin KW - estrogen replacement therapy KW - statins KW - tumors KW - Allergies KW - Cancer KW - prevention KW - Females KW - survival KW - Drugs KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20725445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Risk+of+Multiple+Myeloma+following+Medication+Use+and+Medical+Conditions%3A+A+Case-Control+Study+in+Connecticut+Women&rft.au=Landgren%2C+Ola%3BZhang%2C+Yawei%3BZahm%2C+Sheila+Hoar%3BInskip%2C+Peter%3BZheng%2C+Tongzhang%3BBaris%2C+Dalsu&rft.aulast=Landgren&rft.aufirst=Ola&rft.date=2006-12-01&rft.volume=15&rft.issue=12&rft.spage=2342&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Bioindicators; Historical account; Etiology; multiple myeloma; insulin; estrogen replacement therapy; statins; tumors; Allergies; Cancer; prevention; Females; survival; Drugs; USA, Connecticut ER - TY - JOUR T1 - Reduced fertility among HIV-infected women associated with viral load in Rakai district, Uganda AN - 20586235; 7296322 AB - We assessed whether HIV-1 viral load affects the likelihood of live birth among HIV-positive women in a nested case-control study of HIV-positive women from a community cohort in Rakai District, Uganda. Cases were women who had a live birth (n = 270), and controls were sexually active women who did not use contraception and did not become pregnant during follow-up (n = 263). In women with a live birth and non-pregnant controls, median HIV viral loads were 4.12 log sub(10) copies/mL and 4.41 log sub(10) copies/mL, respectively (P = 0.001). A non-linear association was observed, and a segmented linear regression with spline knot at 4.5 log sub(10) copies/mL was fit. We observed a decline in the log (adjusted odds ratio [adj. OR])=-0.08 (95% confidence interval [CI]: -0.36, 0.20) between 3.0 and 4.49 log sub(10) viral load and -0.92 (95% CI: -1.21, -0.63) between 4.5 and 6.5 log sub(10) viral load. The two reductions differed significantly from one another (P<0.001). Each increase in log sub(10) viral load after 4.5 log sub(10) resulted in an adj. OR of live birth which was 12% of the previous viral load category. Our data suggest that there may be considerable differences in the ability to produce a live birth among HIV-positive women with high viral loads. JF - International Journal of STD & AIDS AU - Nguyen, RHN AU - Gange, S J AU - Wabwire-Mangen, F AU - Sewankambo, N K AU - Serwadda, D AU - Wawer, MJ AU - Quinn, T C AU - Gray, R H AD - Epidemiology Branch, NIEHS/NIH, 111 TW Alexander Drive, PO Box 12233, MD A3-05, Research Triangle Park, NC 27709, USA, nguyen5@niehs.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 842 EP - 846 VL - 17 IS - 12 SN - 0956-4624, 0956-4624 KW - Sustainability Science Abstracts; Virology & AIDS Abstracts KW - Acquired immune deficiency syndrome KW - Fertility KW - Contraception KW - Human immunodeficiency virus KW - Human immunodeficiency virus 1 KW - Uganda KW - Females KW - sexually transmitted diseases KW - Pregnancy KW - V 22360:AIDS and HIV KW - M3 1010:Issues in Sustainable Development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20586235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+STD+%26+AIDS&rft.atitle=Reduced+fertility+among+HIV-infected+women+associated+with+viral+load+in+Rakai+district%2C+Uganda&rft.au=Nguyen%2C+RHN%3BGange%2C+S+J%3BWabwire-Mangen%2C+F%3BSewankambo%2C+N+K%3BSerwadda%2C+D%3BWawer%2C+MJ%3BQuinn%2C+T+C%3BGray%2C+R+H&rft.aulast=Nguyen&rft.aufirst=RHN&rft.date=2006-12-01&rft.volume=17&rft.issue=12&rft.spage=842&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+STD+%26+AIDS&rft.issn=09564624&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fertility; Contraception; Pregnancy; Acquired immune deficiency syndrome; Human immunodeficiency virus; Females; sexually transmitted diseases; Human immunodeficiency virus 1; Uganda ER - TY - JOUR T1 - Magnetic resonance imaging at 1.5 T with immunospecific contrast agent in vitro and in vivo in a xenotransplant model AN - 20341330; 7748913 AB - Object: Demonstrating the feasibility of magnetic resonance imaging (MRI) at 1.5 T of ultrasmall particle iron oxide (USPIO)-antibody bound to tumor cells in vitro and in a murine xenotransplant model. Methods: Human D430B cells or Raji Burkitt lymphoma cells were incubated in vitro with different amounts of commercially available USPIO-anti-CD20 antibodies and cell pellets were stratified in a test tube. For in vivo studies, D430B cells and Raji lymphoma cells were inoculated subcutaneously in immunodeficient mice. MRI at 1.5 T was performed with T1-weighted three-dimensional fast field echo sequences (17/4.6/13 degree ) and T2-weighted three-dimensional fast-field echo sequences (50/12/7 degree ). For in vivo studies MRI was performed before and 24 h after USPIO-anti-CD20 administration. Results: USPIO-anti-CD20-treated D430B cells, showed a dose-dependent decrease in signal intensity (SI) on T2*-weighted images and SI enhancement on T1-weighted images in vitro. Raji cells showed lower SI changes, in accordance to the fivefold lower expression of CD20 on Raji with respect to D430B cells. In vivo 24 h after USPIO-anti-CD20 administration, both tumors showed an inhomogeneous decrease of SI on T2*-weighted images and SI enhancement on T1-weighted images. Conclusions: MRI at 1.5 T is able to detect USPIO-antibody conjugates targeting a tumor-associated antigen in vitro and in vivo. JF - Magnetic Resonance Materials in Biology, Physics, and Medicine AU - Baio, G AU - Fabbi, M AU - de Totero, D AU - Ferrini, S AU - Cilli, M AU - Derchi, LE AU - Neumaier, CE AD - Department of Diagnostic Imaging, IST, National Cancer Institute, Largo Rosanna Benzi 10, 16100 Genoa, Italy Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 313 EP - 320 VL - 19 IS - 6 SN - 0968-5243, 0968-5243 KW - Biotechnology and Bioengineering Abstracts KW - iron oxides KW - Magnetic resonance imaging KW - Immunodeficiency KW - Animal models KW - Tumors KW - Tumor cells KW - Burkitt's lymphoma KW - Antibodies KW - CD20 antigen KW - Antigen (tumor-associated) KW - Contrast media KW - N.M.R. KW - Lymphoma KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20341330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Materials+in+Biology%2C+Physics%2C+and+Medicine&rft.atitle=Magnetic+resonance+imaging+at+1.5+T+with+immunospecific+contrast+agent+in+vitro+and+in+vivo+in+a+xenotransplant+model&rft.au=Baio%2C+G%3BFabbi%2C+M%3Bde+Totero%2C+D%3BFerrini%2C+S%3BCilli%2C+M%3BDerchi%2C+LE%3BNeumaier%2C+CE&rft.aulast=Baio&rft.aufirst=G&rft.date=2006-12-01&rft.volume=19&rft.issue=6&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Materials+in+Biology%2C+Physics%2C+and+Medicine&rft.issn=09685243&rft_id=info:doi/10.1007%2Fs10334-006-0059-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - iron oxides; Magnetic resonance imaging; Animal models; Immunodeficiency; Tumors; Tumor cells; Burkitt's lymphoma; Antibodies; Antigen (tumor-associated); CD20 antigen; Contrast media; N.M.R.; Lymphoma DO - http://dx.doi.org/10.1007/s10334-006-0059-6 ER - TY - JOUR T1 - Augmented Designs to Assess Immune Response in Vaccine Trials AN - 20283062; 7215167 AB - This article introduces methods for use in vaccine clinical trials to help determine whether the immune response to a vaccine is actually causing a reduction in the infection rate. This is not easy because immune response to the (say HIV) vaccine is only observed in the HIV vaccine arm. If we knew what the HIV-specific immune response in placebo recipients would have been, had they been vaccinated, this immune response could be treated essentially like a baseline covariate and an interaction with treatment could be evaluated. Relatedly, the rate of infection by this baseline covariate could be compared between the two groups and a causative role of immune response would be supported if infection risk decreased with increasing HIV immune response only in the vaccine group. We introduce two methods for inferring this HIV-specific immune response. The first involves vaccinating everyone before baseline with an irrelevant vaccine, for example, rabies. Randomization ensures that the relationship between the immune responses to the rabies and HIV vaccines observed in the vaccine group is the same as what would have been seen in the placebo group. We infer a placebo volunteer's response to the HIV vaccine using their rabies response and a prediction model from the vaccine group. The second method entails vaccinating all uninfected placebo patients at the closeout of the trial with the HIV vaccine and recording immune response. We pretend this immune response at closeout is what they would have had at baseline. We can then infer what the distribution of immune response among placebo infecteds would have been. Such designs may help elucidate the role of immune response in preventing infections. More pointedly, they could be helpful in the decision to improve or abandon an HIV vaccine with mediocre performance in a phase III trial. JF - Biometrics AU - Follmann, Dean AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700B Rockledge Drive MSC 7609, Bethesda, Maryland 20892, U.S.A, dfollmann@niaid.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1161 EP - 1169 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 62 IS - 4 SN - 0006-341X, 0006-341X KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Human immunodeficiency virus KW - Rabies KW - Rabies virus KW - Vaccines KW - Immune response KW - Biometrics KW - Infection KW - Clinical trials KW - Models KW - V 22360:AIDS and HIV KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20283062?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Augmented+Designs+to+Assess+Immune+Response+in+Vaccine+Trials&rft.au=Follmann%2C+Dean&rft.aulast=Follmann&rft.aufirst=Dean&rft.date=2006-12-01&rft.volume=62&rft.issue=4&rft.spage=1161&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.1541-0420.2006.00569.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 3; tables, 4; formulas, 110; references, 21. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Rabies; Biometrics; Immune response; Vaccines; Infection; Clinical trials; Models; Human immunodeficiency virus; Rabies virus DO - http://dx.doi.org/10.1111/j.1541-0420.2006.00569.x ER - TY - JOUR T1 - Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement AN - 20129622; 7208766 AB - Cells lining the gastrointestinal tract serve as both a barrier to and a pathway for infectious agent entry. Dendritic cells (DCs) present in the lamina propria under the columnar villus epithelium of the small bowel extend processes across this epithelium and capture bacteria, but previous studies provided limited information on the nature of the stimuli, receptors, and signaling events involved in promoting this phenomenon. Here, we use immunohistochemical as well as dynamic explant and intravital two-photon imaging to investigate this issue. Analysis of CD11c-enhanced green fluorescent protein (EGFP) or major histocompatibility complex CII-EGFP mice revealed that the number of trans-epithelial DC extensions, many with an unusual "balloon" shape, varies along the length of the small bowel. High numbers of such extensions were found in the proximal jejunum, but only a few were present in the terminal ileum. The extensions in the terminal ileum markedly increased upon the introduction of invasive or noninvasive Salmonella organisms, and chimeric mouse studies revealed the key role of MyD88-dependent Toll-like receptor (TLR) signaling by nonhematopoietic (epithelial) elements in the DC extension response. Collectively, these findings support a model in which epithelial cell TLR signaling upon exposure to microbial stimuli induces active DC sampling of the gut lumen at sites distant from organized lymphoid tissues. JF - Journal of Experimental Medicine AU - Chieppa, Marcello AU - Rescigno, Maria AU - Huang, Alex YC AU - Germain, Ronald N AD - Lymphocyte Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892. Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2841 EP - 2852 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 203 IS - 13 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Epithelial cells KW - Green fluorescent protein KW - Animal models KW - Major histocompatibility complex KW - Ileum KW - imaging KW - Lymphoid tissue KW - Balloons KW - Dendritic cells KW - Villus KW - Digestive tract KW - Jejunum KW - Intestine KW - Epithelium KW - Sampling KW - Gastrointestinal tract KW - Salmonella KW - lamina propria KW - Explants KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20129622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Dynamic+imaging+of+dendritic+cell+extension+into+the+small+bowel+lumen+in+response+to+epithelial+cell+TLR+engagement&rft.au=Chieppa%2C+Marcello%3BRescigno%2C+Maria%3BHuang%2C+Alex+YC%3BGermain%2C+Ronald+N&rft.aulast=Chieppa&rft.aufirst=Marcello&rft.date=2006-12-01&rft.volume=203&rft.issue=13&rft.spage=2841&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Animal models; Green fluorescent protein; Major histocompatibility complex; Ileum; imaging; Lymphoid tissue; Balloons; Dendritic cells; Villus; Digestive tract; Jejunum; Intestine; Epithelium; Gastrointestinal tract; Sampling; Explants; lamina propria; Toll-like receptors; Signal transduction; Salmonella ER - TY - JOUR T1 - Transforming Growth Factor-{beta}1 Sensitivity Is Altered in Abl-Myc- and Raf-Myc-Induced Mouse Pre-B-Cell Tumors AN - 20014046; 7210875 AB - Understanding the mechanisms leading to transformation of early B-lineage precursors is an important step leading to rational design of new treatments for precursor (pre)-B-cell leukemia. We used normal mouse pre-B cells to determine if and how transforming growth factor (TGF)-{beta}1 affects these precursors to the B-cell lineage and whether transformed pre-B cells respond to TGF-{beta}1. We found that normal pre-B cells proliferating in the presence of interleukin (IL)-7 enter cell-cycle arrest after exposure to TGF-{beta}1. However, clonally related IL-7-independent tumors induced by oncogenes abl + myc or raf + myc have reduced sensitivity to TGF-{beta}1. In contrast, tumor cells induced by myc alone remain sensitive to TGF-{beta}1 growth suppression. These results suggest that lesions in different molecular signaling pathways can lead to loss of TGF-{beta}1 sensitivity in a single cell type. The approach of using normal pre-B-cell lines and transformation by overexpression of different oncogenes provides a system to compare and contrast molecular pathways that lead to full malignancy. JF - Stem Cells AU - Letterio, John AU - Rudikoff, Eva AU - Voong, Nga AU - Bauer, Steven R AD - Case Western Reserve University, Division of Pediatric Hematology/Oncology, The Ireland Cancer Center, Cleveland, Ohio, USA. Food and Drug Administration, Center for Biologics Evaluation and Research, Cell and Tissue Therapy Branch, Rockville, Maryland, USA. National Institutes of Health, National Cancer Institute, Laboratory of Cell Regulation and Carcinogenesis, Bethesda, Maryland, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2611 EP - 2617 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Transformation KW - Transforming growth factor KW - Lymphocytes B KW - Tumors KW - Tumor cells KW - Myc protein KW - Leukemia KW - Malignancy KW - Stem cells KW - Raf protein KW - Oncogenes KW - Signal transduction KW - W 30925:Genetic Engineering KW - B 26630:Nuclear & DNA-binding proteins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20014046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Transforming+Growth+Factor-%7Bbeta%7D1+Sensitivity+Is+Altered+in+Abl-Myc-+and+Raf-Myc-Induced+Mouse+Pre-B-Cell+Tumors&rft.au=Letterio%2C+John%3BRudikoff%2C+Eva%3BVoong%2C+Nga%3BBauer%2C+Steven+R&rft.aulast=Letterio&rft.aufirst=John&rft.date=2006-12-01&rft.volume=24&rft.issue=12&rft.spage=2611&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Myc protein; Leukemia; Transforming growth factor; Raf protein; Stem cells; Malignancy; Oncogenes; Lymphocytes B; Tumors; Tumor cells; Signal transduction ER - TY - JOUR T1 - Identification of key genes responsible for cytokine-induced erythroid and myeloid differentiation and switching of hematopoietic stem cells by RAGE AN - 19993330; 7355102 AB - We utilized a unique culture system to analyze the expression patterns of gene, protein, and cell surface antigen, and the biological process of the related genes in erythroid and myeloid differentiation and switching of hematopoietic stem cells (HSCs) in response to cytokine alterations. Gene-specific fragments (266) identified from five populations of cytokine-stimutated HSCs were categorized into three groups: (1) expressed specifically in a single cell population; (2) expressed in two cell populations, and (3) expressed in three or more populations. Of 145 defined cDNAs, three (2%) were novel genes. Protein two-dimensional gel electrophoresis and flow cytometry analyses showed overlapped and distinguished protein expression profiles in the cell populations studied. Biological process mapping of mRNAs expressed in erythroid and myeloid lineages indicated that mRNAs shared by both lineages attended 'core processes,' whereas genes specifically expressed in either lineage alone were related to specific processes or cellular maturation. Data from this study support the hypothesis that committed HSCs (E14 or G14) cells can still be redirected to develop into myeloid or erythroid cells when erythropoietin (EPO) is replaced with granulocyte-colony stimulating factor (G-CSF) under erythroid-cultured condition or G-CSF with EPO in myeloid-cultured environment, respectively. Our results suggest that genes or proteins co-expressed in erythroid and myeloid lineages may be essential for the lineage maintenance and switching in hematopoiesis. JF - Cell Research AU - Chen, L AU - Zhang, H AU - Shi, Y AU - Chin, K L AU - Tang, D C AU - Rodgers, G P AD - Molecular and Clinical Hematology Branch (MCHB), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA, gprod@helix.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 923 EP - 939 VL - 16 IS - 12 SN - 1001-0602, 1001-0602 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Cell surface KW - Data processing KW - Erythroid cells KW - Population studies KW - Granulocyte colony-stimulating factor KW - Gel electrophoresis KW - mRNA KW - Flow cytometry KW - Differentiation KW - Stem cells KW - Erythropoietin KW - Hemopoiesis KW - Cytokines KW - Gene mapping KW - G 07720:Immunogenetics KW - W 30900:Methods KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19993330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell+Research&rft.atitle=Identification+of+key+genes+responsible+for+cytokine-induced+erythroid+and+myeloid+differentiation+and+switching+of+hematopoietic+stem+cells+by+RAGE&rft.au=Chen%2C+L%3BZhang%2C+H%3BShi%2C+Y%3BChin%2C+K+L%3BTang%2C+D+C%3BRodgers%2C+G+P&rft.aulast=Chen&rft.aufirst=L&rft.date=2006-12-01&rft.volume=16&rft.issue=12&rft.spage=923&rft.isbn=&rft.btitle=&rft.title=Cell+Research&rft.issn=10010602&rft_id=info:doi/10.1038%2Fsj.cr.7310115 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell surface; Data processing; Erythroid cells; Population studies; Granulocyte colony-stimulating factor; Gel electrophoresis; mRNA; Flow cytometry; Differentiation; Stem cells; Erythropoietin; Cytokines; Hemopoiesis; Gene mapping DO - http://dx.doi.org/10.1038/sj.cr.7310115 ER - TY - JOUR T1 - Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion AN - 19980234; 7210897 AB - Epithelial stem cells (EP-SCs) located in the bulge region of a hair follicle (HF) have the potential to give rise to hair follicle stem/progenitor cells that migrate down to regenerate HFs. Bone morphogenetic protein (BMP) signaling has been shown to regulate the HF cycle by inhibiting anagen induction. Here we show that active BMP signaling functions to prevent EP-SC activation and expansion. Dynamic expression of Noggin, a BMP antagonist, releases EP-SCs from BMP-mediated restriction, leading to EP-SC activation and initiation of the anagen phase. Experimentally induced conditional inactivation of the BMP type IA receptor (Bmpr1a) in EP-SCs leads to overproduction of HF stem/progenitor cells and the eventual formation of matricomas. This genetic manipulation of the BMP signaling pathway also reveals unexpected activation of {szligbeta}-catenin, a major mediator of Wnt signaling. We propose that BMP activity controls the HF cycle by antagonizing Wnt/{szligbeta}-catenin activity. This is at least partially achieved by BMP-mediated enhancement of transforming growth factor-{szligbeta}-regulated epithelial cell-specific phosphatase (PTEN) function. Subsequently, PTEN, through phosphatidyl inositol 3-kinase-Akt, inhibits the activity of {szligbeta}-catenin, the convergence point of the BMP and Wnt signaling pathways. JF - Stem Cells AU - Zhang, Jiwang AU - He, Xi C AU - Tong, Wei-Gang AU - Johnson, Teri AU - Wiedemann, Leanne M AU - Mishina, Yuji AU - Feng, Jian Q AU - Li, Linheng AD - Stowers Institute for Medical Research, Kansas City, Missouri, USA. Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA. Department of Oral Biology, School of Dentistry, University of Missouri-Kansas City, Kansas City, Missouri, USA. Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, Kansas, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2826 EP - 2839 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 12 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Wnt protein KW - Follicles KW - Inositol KW - PTEN protein KW - Noggin protein KW - Hair KW - Cell activation KW - Bone morphogenetic proteins KW - Stem cells KW - Convergence KW - Cell migration KW - Signal transduction KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19980234?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Bone+Morphogenetic+Protein+Signaling+Inhibits+Hair+Follicle+Anagen+Induction+by+Restricting+Epithelial+Stem%2FProgenitor+Cell+Activation+and+Expansion&rft.au=Zhang%2C+Jiwang%3BHe%2C+Xi+C%3BTong%2C+Wei-Gang%3BJohnson%2C+Teri%3BWiedemann%2C+Leanne+M%3BMishina%2C+Yuji%3BFeng%2C+Jian+Q%3BLi%2C+Linheng&rft.aulast=Zhang&rft.aufirst=Jiwang&rft.date=2006-12-01&rft.volume=24&rft.issue=12&rft.spage=2826&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Stem cells; Bone morphogenetic proteins; Wnt protein; Follicles; Convergence; Inositol; Cell migration; Noggin protein; PTEN protein; Hair; Cell activation; Signal transduction ER - TY - JOUR T1 - Sporadic Lymphangioleiomyomatosis and Tuberous Sclerosis Complex with Lymphangioleiomyomatosis: Comparison of CT Features AN - 19968154; 7210637 AB - PURPOSE: To retrospectively compare the frequencies of computed tomographic (CT) findings in patients with lymphangioleiomyomatosis (LAM) and patients with tuberous sclerosis complex (TSC) and LAM. MATERIALS AND METHODS: Institutional review board approval and informed consent were obtained for the HIPAA-compliant study. In 256 patients with LAM (mean age, 44 years) and 67 patients with TSC/LAM (mean age, 40 years), CT scans of the chest, abdomen, and pelvis were reviewed by a single radiologist. The fraction of lung involvement with cysts was estimated from high-spatial-resolution CT scans. Other findings assessed included noncalcified pulmonary nodules, pleural effusion, thoracic duct dilatation, hepatic and renal angiomyolipomas (AMLs), lymphangioleiomyoma (LALM), ascites, nephrectomy, and renal embolization. Confidence intervals and hypothesis tests of differences in frequencies, comparison of age quartiles, RIDIT analysis, analysis of variance, and correlation coefficients were used in the statistical analysis. RESULTS: Patients with LAM had more extensive lung involvement (RIDIT score, 0.36) and higher frequency of LALM (29% vs 9%, P < .001), thoracic duct dilatation (4% vs 0, P = .3), pleural effusion (12% vs 6%, P = .2), or ascites (10% vs 6%, P = .3). Patients with TSC/LAM had higher frequency of noncalcified pulmonary nodules (12% vs 1%, P < .01), hepatic (33% vs 2%, P < .001) and renal (93% vs 32%, P < .001) AMLs, nephrectomy (25% vs 7%, P < .001), or renal artery embolization (9% vs 2%, P < .05). CONCLUSION: The extent of lung disease is greater in LAM than TSC/LAM. Hepatic and renal AMLs and noncalcified lung nodules are more common in TSC/LAM, while lymphatic involvement-thoracic duct dilatation, chylous pleural effusion, ascites, and LALM-is more common in LAM. [copy ] RSNA, 2006 JF - Radiology AU - Avila, Nilo A AU - Dwyer, Andrew J AU - Rabel, Antoinette AU - Moss, Joel AD - Diagnostic Radiology Department, Warren G. Magnuson Clinical Center (N.A.A., A.J.D.), and Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute (A.R., J.M.), National Institutes of Health, Bldg 10, Room 1C-660, 10 Center Dr, MSC 1182, Bethesda, MD 20892-1182 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 277 EP - 285 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 242 IS - 1 SN - 0033-8419, 0033-8419 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - tuberous sclerosis KW - Age KW - Renal artery KW - Statistical analysis KW - Pleural effusion KW - Angiomyolipoma KW - Chest KW - Nodules KW - Embolization KW - Abdomen KW - Lung diseases KW - Lung nodules KW - Thoracic duct KW - Cysts KW - Pelvis KW - Nephrectomy KW - Ascites KW - Computed tomography KW - Kidney KW - Liver KW - W 30910:Imaging KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19968154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Sporadic+Lymphangioleiomyomatosis+and+Tuberous+Sclerosis+Complex+with+Lymphangioleiomyomatosis%3A+Comparison+of+CT+Features&rft.au=Avila%2C+Nilo+A%3BDwyer%2C+Andrew+J%3BRabel%2C+Antoinette%3BMoss%2C+Joel&rft.aulast=Avila&rft.aufirst=Nilo&rft.date=2006-12-01&rft.volume=242&rft.issue=1&rft.spage=277&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Computed tomography; Pleural effusion; Ascites; Lung nodules; Liver; Age; Nephrectomy; Thoracic duct; Embolization; tuberous sclerosis; Cysts; Angiomyolipoma; Statistical analysis; Chest; Pelvis; Lung diseases; Renal artery; Abdomen; Kidney; Nodules ER - TY - JOUR T1 - Deficient expression of monoamine oxidase A in the endometrium is associated with implantation failure in women participating as recipients in oocyte donation AN - 19961631; 7193767 AB - Successful implantation depends both on the quality of the embryo and on the endometrial receptivity. The latter depends on progesterone-induced changes in gene expression, a process that has been characterized by microarray analysis. One of the genes whose transcription appears to be enhanced during the receptive period is monoamine oxidase A (MAO-A). Our first objective was to confirm the increased expression of MAO-A in the endometrium during the receptive phase of spontaneous normal cycles using real time PCR and immunofluorescence. The second objective was to examine the endometrial expression of MAO-A during the receptive phase induced by exogenous estradiol (E sub(2)) and progesterone in patients whose endometrium was shown to have been either receptive or non-receptive to embryo implantation in repeated cycles of oocyte donation. Results showed that MAO-A transcript levels increased between the pre-receptive (LH+3) and receptive phase (LH+7) in all spontaneous cycles examined, with a median increase of 25-fold. Immunofluorescent labelling demonstrated MAO-A localization to the glandular and luminal epithelium with an increasing positive score between LH+3 and LH+7. Conversely, prior failure of embryo implantation was associated with a 29-fold decrease in MAO-A mRNA levels and a substantial reduction in MAO-A protein immunofluorescent label score. These results show a strong association between endometrial receptivity and MAO-A expression in the endometrial epithelium, suggesting an important role for this enzyme in normal implantation. JF - Molecular Human Reproduction AU - Henriquez, S AU - Tapia, A AU - Quezada, M AU - Vargas, M AU - Cardenas, H AU - Rios, M AU - Salvatierra, A M AU - Croxatto, H AU - Orihuela, P AU - Zegers-Hochschild, F AU - Munroe, D J AU - Velasquez, L AD - Laboratorio de Inmunologia de la Reproduccion, Universidad de Santiago de Chile, Instituto Chileno de Medicina Reproductiva, Millenium Institute for Fundamental and Applied Biology, Clinica Las Condes, Santiago, Chile and Laboratory of Molecular Technology, SAIC-Frederick, National Cancer Institute at Frederick, Frederick, MD, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 749 EP - 754 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 12 IS - 12 SN - 1360-9947, 1360-9947 KW - Biotechnology and Bioengineering Abstracts KW - Endometrium KW - Progesterone KW - Amine oxidase (flavin-containing) KW - Enzymes KW - Transcription KW - Immunofluorescence KW - DNA microarrays KW - Estradiol KW - Gene expression KW - Polymerase chain reaction KW - Oocytes KW - Epithelium KW - Embryos KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19961631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Human+Reproduction&rft.atitle=Deficient+expression+of+monoamine+oxidase+A+in+the+endometrium+is+associated+with+implantation+failure+in+women+participating+as+recipients+in+oocyte+donation&rft.au=Henriquez%2C+S%3BTapia%2C+A%3BQuezada%2C+M%3BVargas%2C+M%3BCardenas%2C+H%3BRios%2C+M%3BSalvatierra%2C+A+M%3BCroxatto%2C+H%3BOrihuela%2C+P%3BZegers-Hochschild%2C+F%3BMunroe%2C+D+J%3BVelasquez%2C+L&rft.aulast=Henriquez&rft.aufirst=S&rft.date=2006-12-01&rft.volume=12&rft.issue=12&rft.spage=749&rft.isbn=&rft.btitle=&rft.title=Molecular+Human+Reproduction&rft.issn=13609947&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Endometrium; Progesterone; Amine oxidase (flavin-containing); Transcription; Enzymes; Immunofluorescence; DNA microarrays; Estradiol; Gene expression; Oocytes; Polymerase chain reaction; Embryos; Epithelium ER - TY - JOUR T1 - Microbial translocation is a cause of systemic immune activation in chronic HIV infection AN - 19929136; 7161778 AB - Chronic activation of the immune system is a hallmark of progressive HIV infection and better predicts disease outcome than plasma viral load, yet its etiology remains obscure. Here we show that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation. Circulating lipopolysaccharide, which we used as an indicator of microbial translocation, was significantly increased in chronically HIV-infected individuals and in simian immunodeficiency virus (SIV)-infected rhesus macaques (P < 0.002). We show that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation. Effective antiretroviral therapy seemed to reduce microbial translocation partially. Furthermore, in nonpathogenic SIV infection of sooty mangabeys, microbial translocation did not seem to occur. These data establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection. JF - Nature Medicine AU - Brenchley, Jason M AU - Price, David A AU - Schacker, Timothy W AU - Asher, Tedi E AU - Silvestri, Guido AU - Rao, Srinivas AU - Kazzaz, Zachary AU - Bornstein, Ethan AU - Lambotte, Olivier AU - Altmann, Daniel AU - Blazar, Bruce R AU - Rodriguez, Benigno AU - Teixeira-Johnson, Leia AU - Landay, Alan AU - Martin, Jeffrey N AU - Hecht, Frederick M AU - Picker, Louis J AU - Lederman, Michael M AU - Deeks, Steven G AU - Douek, Daniel C AD - Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA., ddouek@mail.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1365 EP - 1371 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 12 IS - 12 SN - 1078-8956, 1078-8956 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Virology & AIDS Abstracts KW - Etiology KW - Data processing KW - Immune system KW - Mucosa KW - antiretroviral therapy KW - Therapeutic applications KW - Infection KW - Digestive tract KW - Human immunodeficiency virus KW - Chronic infection KW - Lipopolysaccharides KW - Macaca mulatta KW - Gastrointestinal tract KW - Immune response KW - Translocation KW - Simian immunodeficiency virus KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19929136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Microbial+translocation+is+a+cause+of+systemic+immune+activation+in+chronic+HIV+infection&rft.au=Brenchley%2C+Jason+M%3BPrice%2C+David+A%3BSchacker%2C+Timothy+W%3BAsher%2C+Tedi+E%3BSilvestri%2C+Guido%3BRao%2C+Srinivas%3BKazzaz%2C+Zachary%3BBornstein%2C+Ethan%3BLambotte%2C+Olivier%3BAltmann%2C+Daniel%3BBlazar%2C+Bruce+R%3BRodriguez%2C+Benigno%3BTeixeira-Johnson%2C+Leia%3BLanday%2C+Alan%3BMartin%2C+Jeffrey+N%3BHecht%2C+Frederick+M%3BPicker%2C+Louis+J%3BLederman%2C+Michael+M%3BDeeks%2C+Steven+G%3BDouek%2C+Daniel+C&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2006-12-01&rft.volume=12&rft.issue=12&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1511 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Etiology; Data processing; Immune system; antiretroviral therapy; Mucosa; Therapeutic applications; Infection; Digestive tract; Chronic infection; Lipopolysaccharides; Immune response; Gastrointestinal tract; Translocation; Human immunodeficiency virus; Macaca mulatta; Simian immunodeficiency virus DO - http://dx.doi.org/10.1038/nm1511 ER - TY - JOUR T1 - Acquisition of direct antiviral effector functions by CMV-specific CD4 super(+) T lymphocytes with cellular maturation AN - 19856602; 7208768 AB - The role of CD4 super(+) T cells in the control of persistent viral infections beyond the provision of cognate help remains unclear. We used polychromatic flow cytometry to evaluate the production of the cytokines interferon (IFN)- gamma , tumor necrosis factor (TNF)- alpha , and interleukin (IL)-2, the chemokine macrophage inflammatory protein (MIP)-1{beta}, and surface mobilization of the degranulation marker CD107a by CD4 super(+) T cells in response to stimulation with cytomegalovirus (CMV)-specific major histocompatibility complex class II peptide epitopes. Surface expression of CD45RO, CD27, and CD57 on responding cells was used to classify CD4 super(+) T cell maturation. The functional profile of virus-specific CD4 super(+) T cells in chronic CMV infection was unique compared with that observed in other viral infections. Salient features of this profile were: (a) the simultaneous production of MIP-1{beta}, TNF- alpha , and IFN- gamma in the absence of IL-2; and (b) direct cytolytic activity associated with surface mobilization of CD107a and intracellular expression of perforin and granzymes. This polyfunctional profile was associated with a terminally differentiated phenotype that was not characterized by a distinct clonotypic composition. Thus, mature CMV-specific CD4 super(+) T cells exhibit distinct functional properties reminiscent of antiviral CD8 super(+) T lymphocytes. JF - Journal of Experimental Medicine AU - Casazza, Joseph P AU - Betts, Michael R AU - Price, David A AU - Precopio, Melissa L AU - Ruff, Laura E AU - Brenchley, Jason M AU - Hill, Brenna J AU - Roederer, Mario AU - Douek, Daniel C AU - Koup, Richard A AD - Immunology Laboratory, Human Immunology Section, and Immunotechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892. Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2865 EP - 2877 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 203 IS - 13 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Perforin KW - Chemokines KW - Interleukin 2 KW - Serine proteinase KW - Major histocompatibility complex KW - CD8 antigen KW - Infection KW - Antiviral activity KW - Cytomegalovirus KW - Flow cytometry KW - CD4 antigen KW - Cytolytic activity KW - CD57 antigen KW - CD27 antigen KW - Degranulation KW - Chronic infection KW - Lymphocytes T KW - Tumor necrosis factor- alpha KW - Macrophage inflammatory protein KW - Epitopes KW - endopeptidase KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19856602?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=Acquisition+of+direct+antiviral+effector+functions+by+CMV-specific+CD4+super%28%2B%29+T+lymphocytes+with+cellular+maturation&rft.au=Casazza%2C+Joseph+P%3BBetts%2C+Michael+R%3BPrice%2C+David+A%3BPrecopio%2C+Melissa+L%3BRuff%2C+Laura+E%3BBrenchley%2C+Jason+M%3BHill%2C+Brenna+J%3BRoederer%2C+Mario%3BDouek%2C+Daniel+C%3BKoup%2C+Richard+A&rft.aulast=Casazza&rft.aufirst=Joseph&rft.date=2006-12-01&rft.volume=203&rft.issue=13&rft.spage=2865&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Perforin; gamma -Interferon; Chemokines; Serine proteinase; Interleukin 2; Major histocompatibility complex; CD8 antigen; Antiviral activity; Infection; Flow cytometry; CD4 antigen; Cytolytic activity; CD27 antigen; CD57 antigen; Degranulation; Chronic infection; Lymphocytes T; Tumor necrosis factor- alpha; Macrophage inflammatory protein; Epitopes; endopeptidase; Cytomegalovirus ER - TY - JOUR T1 - Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model AN - 19852589; 7078587 AB - Swertia chirata, is a bitter plant, used in the Indian system of medicine (Ayurveda) for various human ailments. Our laboratory was the first to report the chemopreventive effect of this plant. The antiproliferative and pro- apoptotic action of amarogentin rich fraction of S. chirata is now demonstrated on a mouse skin carcinogenesis model. Immunohistochemical localization revealed a reduction in proliferating and increase in apoptotic cells in skin lesion following treatment, also reflected in the expression of molecular markers - Cox-II and caspase-3 proteins. It may be possible to calculate relative risk, relative protection and attributable risk from the action of test agents on proliferation and apoptosis. JF - Cancer Letters AU - Saha, Prosenjit AU - Mandal, Suvra AU - Das, Ashes AU - Das, Sukta AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India, prosenjit_cnci@yahoo.co.in Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 252 EP - 259 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 244 IS - 2 SN - 0304-3835, 0304-3835 KW - Toxicology Abstracts KW - Swertia KW - Amarogentin KW - Chemoprevention KW - Apoptosis KW - Cox-II KW - Caspase-3 KW - Risk assessment KW - Swertia chirata KW - Skin diseases KW - Bitter taste KW - Carcinogenesis KW - Medicinal plants KW - Animal models KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19852589?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Letters&rft.atitle=Amarogentin+can+reduce+hyperproliferation+by+downregulation+of+Cox-II+and+upregulation+of+apoptosis+in+mouse+skin+carcinogenesis+model&rft.au=Saha%2C+Prosenjit%3BMandal%2C+Suvra%3BDas%2C+Ashes%3BDas%2C+Sukta&rft.aulast=Saha&rft.aufirst=Prosenjit&rft.date=2006-12-01&rft.volume=244&rft.issue=2&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Cancer+Letters&rft.issn=03043835&rft_id=info:doi/10.1016%2Fj.canlet.2005.12.036 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Apoptosis; Skin diseases; Bitter taste; Medicinal plants; Carcinogenesis; Caspase-3; Animal models; Swertia chirata DO - http://dx.doi.org/10.1016/j.canlet.2005.12.036 ER - TY - JOUR T1 - Review article: The role of inflammation in preterm birth-focus on periodontitis AN - 19827899; 7225088 AB - It is universally accepted that acute inflammation is responsible for a substantial fraction of preterm births, particularly early cases. Much of this inflammation is caused by intrauterine infection. There is also evidence that infection and perhaps inflammation remote from the genitourinary tract can trigger preterm labour. Several studies have suggested that periodontitis during pregnancy increases the risk of preterm birth. Periodontitis may cause preterm birth by causing low-grade bacteraemia, which lodges in the decidua, chorion and amnion or by releasing endotoxin into the maternal circulation, which triggers intrauterine inflammation and preterm birth. Alternatively, it may release cytokines and other inflammatory products, which then trigger preterm labour. It is also conceivable that periodontitis might serve as a marker for other unhealthy behaviours, or immune hyperresponsiveness and that hyperresponsiveness to low-grade intrauterine infection itself might cause preterm birth. Currently, there are few data available to distinguish these possibilities. Such distinctions are important since they have clear implications for whether treatment of periodontitis might reduce the incidence of preterm birth. Several clinical trials of treatment of periodontitis are continuing, but until their results are known there is currently little evidence that treatment of periodontitis during pregnancy reduces the incidence of preterm birth. JF - BJOG AU - Klebanoff, M AU - Searle, K AD - Department of Health and Human Services, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA, klebanom@exchange.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 43 EP - 45 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 113 IS - s3 SN - 1470-0328, 1470-0328 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Endotoxins KW - decidua KW - Data processing KW - Bacteremia KW - Genitourinary tract KW - Infection KW - Clinical trials KW - Pregnancy KW - Inflammation KW - Birth KW - Periodontitis KW - Cytokines KW - Chorion KW - Amnion KW - A 01490:Miscellaneous KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19827899?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BJOG&rft.atitle=Review+article%3A+The+role+of+inflammation+in+preterm+birth-focus+on+periodontitis&rft.au=Klebanoff%2C+M%3BSearle%2C+K&rft.aulast=Klebanoff&rft.aufirst=M&rft.date=2006-12-01&rft.volume=113&rft.issue=s3&rft.spage=43&rft.isbn=&rft.btitle=&rft.title=BJOG&rft.issn=14700328&rft_id=info:doi/10.1111%2Fj.1471-0528.2006.01121.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - SuppNotes - References, 15. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - decidua; Endotoxins; Data processing; Bacteremia; Genitourinary tract; Infection; Clinical trials; Inflammation; Pregnancy; Birth; Periodontitis; Cytokines; Amnion; Chorion DO - http://dx.doi.org/10.1111/j.1471-0528.2006.01121.x ER - TY - JOUR T1 - Dissecting carbohydrate-Cyanovirin-N binding by structure-guided mutagenesis: functional implications for viral entry inhibition AN - 19792245; 7194078 AB - The HIV-inactivating protein Cyanovirin-N (CV-N) is a cyanobacterial lectin that exhibits potent antiviral activity at nanomolar concentrations by interacting with high-mannose carbohydrates on viral glycoproteins. To date there is no molecular explanation for this potent virucidal activity, given the experimentally measured micromolar affinities for small sugars and the problems encountered with aggregation and precipitation of high-mannose/CV-N complexes. Here, we present results for two CV-N variants, CV-N super(mutDA) and CV-N super(mutDB), compare their binding properties with monomeric [P51G]CV-N (a stabilized version of wtCV-N) and test their in vitro activities. The mutations in CV-N super(mutDA) and CV-N super(mutDB) comprise changes in amino acids that alter the trimannose specificity of domain A super(M) and abolish the sugar binding site on domain B super(M), respectively. We demonstrate that carbohydrate binding via domain B super(M) is essential for antiviral activity, whereas alterations in sugar binding specificity on domain A super(M) have little effect on envelope glycoprotein recognition and antiviral activity. Changes in A super(M), however, affect the cross-linking activity of CV-N. Our findings augment and clarify the existing models of CV-N binding to N-linked glycans on viral glycoproteins, and demonstrate that the nanomolar antiviral potency of CV-N is related to the constricted and spatially crowded arrangement of the mannoses in the glycan clusters on viral glycoproteins and not due to CV-N induced virus particle agglutination, making CV-N a true viral entry inhibitor. JF - Protein Engineering Design and Selection AU - Barrientos, Laura G AU - Matei, Elena AU - Lasala, Fatima AU - Delgado, Rafael AU - Gronenborn, Angela M AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD 20892, USA. Special Pathogens Branch, Division of Viral and Rickettsial Diseases National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. Laboratory of Molecular Microbiology, Hospital Universitario 12 de Octubre Madrid, Spain. Department of Structural Biology, University of Pittsburgh Medical School Pittsburgh, PA 15260, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 525 EP - 535 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 19 IS - 12 SN - 1741-0126, 1741-0126 KW - HIV KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Amino acids KW - Protein engineering KW - Mannose KW - Lectins KW - Precipitation KW - Polysaccharides KW - Antiviral activity KW - Models KW - Mutagenesis KW - Agglutination KW - cyanovirin-N KW - Envelopes KW - N-linked glycans KW - Human immunodeficiency virus KW - Carbohydrates KW - Glycoproteins KW - Mutation KW - Amino acid sequence KW - W 30925:Genetic Engineering KW - V 22360:AIDS and HIV KW - K 03310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19792245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Engineering+Design+and+Selection&rft.atitle=Dissecting+carbohydrate-Cyanovirin-N+binding+by+structure-guided+mutagenesis%3A+functional+implications+for+viral+entry+inhibition&rft.au=Barrientos%2C+Laura+G%3BMatei%2C+Elena%3BLasala%2C+Fatima%3BDelgado%2C+Rafael%3BGronenborn%2C+Angela+M&rft.aulast=Barrientos&rft.aufirst=Laura&rft.date=2006-12-01&rft.volume=19&rft.issue=12&rft.spage=525&rft.isbn=&rft.btitle=&rft.title=Protein+Engineering+Design+and+Selection&rft.issn=17410126&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acids; Protein engineering; Mannose; Lectins; Precipitation; Antiviral activity; Polysaccharides; Mutagenesis; Models; cyanovirin-N; Agglutination; Envelopes; N-linked glycans; Glycoproteins; Carbohydrates; Mutation; Amino acid sequence; Human immunodeficiency virus ER - TY - JOUR T1 - Structure of the Escherichia coli DNA Polymerase III epsilon -HOT Proofreading Complex AN - 19791365; 7208132 AB - The epsilon subunit of Escherichia coli DNA polymerase III possesses 3'-exonucleolytic proofreading activity. Within the Pol III core, epsilon is tightly bound between the alpha subunit (DNA polymerase) and {theta} subunit. Here, we present the crystal structure of epsilon in complex with HOT, the bacteriophage P1-encoded homolog of {theta}, at 2.1 Aa resolution. The epsilon -HOT interface is defined by two areas of contact: an interaction of the previously unstructured N terminus of HOT with an edge of the epsilon central beta -sheet as well as interactions between HOT and the catalytically important helix alpha 1-loop-helix alpha 2 motif of epsilon . This structure provides insight into how HOT and, by implication, {theta} may stabilize the epsilon subunit, thus promoting efficient proofreading during chromosomal replication. JF - Journal of Biological Chemistry AU - Kirby, Thomas W AU - Harvey, Scott AU - DeRose, Eugene F AU - Chalov, Sergey AU - Chikova, Anna K AU - Perrino, Fred W AU - Schaaper, Roel M AU - London, Robert E AU - Pedersen, Lars C AD - Laboratory of Structural Biology and the Laboratory of Molecular Genetics, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709 and Department of Biochemistry, Wake Forest University, Winston-Salem, North Carolina 27157 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 38466 EP - 38471 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 50 SN - 0021-9258, 0021-9258 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Replication KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Crystal structure KW - Proofreading KW - J 02330:Biochemistry KW - V 22320:Replication KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19791365?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Structure+of+the+Escherichia+coli+DNA+Polymerase+III+epsilon+-HOT+Proofreading+Complex&rft.au=Kirby%2C+Thomas+W%3BHarvey%2C+Scott%3BDeRose%2C+Eugene+F%3BChalov%2C+Sergey%3BChikova%2C+Anna+K%3BPerrino%2C+Fred+W%3BSchaaper%2C+Roel+M%3BLondon%2C+Robert+E%3BPedersen%2C+Lars+C&rft.aulast=Kirby&rft.aufirst=Thomas&rft.date=2006-12-01&rft.volume=281&rft.issue=50&rft.spage=38466&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phages; Replication; DNA-directed DNA polymerase; Crystal structure; Proofreading; Escherichia coli ER - TY - JOUR T1 - super(13)C-detected HN(CA)C and HMCMC experiments using a single methyl-reprotonated sample for unambiguous methyl resonance assignment AN - 19781299; 7299129 AB - Methyl groups provide an important source of structural and dynamic information in NMR studies of proteins and their complexes. For this purpose sequence-specific assignments of methyl super(1)H and super(13)C resonances are required. In this paper we propose the use of super(13)C-detected 3D HN(CA)C and HMCMC experiments for assignment of methyl super(1)H and super(13)C resonances using a single selectively methyl protonated, perdeuterated and super(13)C/ super(15)N-labeled sample. The high resolution afforded in the super(13)C directly-detected dimension allows one to rapidly and unambiguously establish correlations between backbone H sub(N) strips from the 3D HN(CA)C spectrum and methyl group H sub(m)C sub(m) strips from the HMCMC spectrum by aligning all possible side-chain carbon chemical shifts and their multiplet splitting patterns. The applicability of these experiments for the assignment of methyl super(1)H and super(13)C resonances is demonstrated using the 18.6 kDa B domain of the Escherichia coli mannose transporter (IIB super(Mannose)). JF - Journal of Biomolecular NMR AU - Hu, Kaifeng AU - Voegeli, Beat AU - Clore, GMarius AD - National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892-0520, USA, mariusc@intra.niddk.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 259 EP - 266 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 36 IS - 4 SN - 0925-2738, 0925-2738 KW - Microbiology Abstracts B: Bacteriology KW - Carbon KW - Mannose KW - Escherichia coli KW - N.M.R. KW - Splitting KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19781299?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+NMR&rft.atitle=super%2813%29C-detected+HN%28CA%29C+and+HMCMC+experiments+using+a+single+methyl-reprotonated+sample+for+unambiguous+methyl+resonance+assignment&rft.au=Hu%2C+Kaifeng%3BVoegeli%2C+Beat%3BClore%2C+GMarius&rft.aulast=Hu&rft.aufirst=Kaifeng&rft.date=2006-12-01&rft.volume=36&rft.issue=4&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/10.1007%2Fs10858-006-9090-1 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Carbon; Mannose; N.M.R.; Splitting; Escherichia coli DO - http://dx.doi.org/10.1007/s10858-006-9090-1 ER - TY - JOUR T1 - Dietary deprivation extends lifespan in Caenorhabditis elegans AN - 19775294; 7213218 AB - Dietary restriction (DR) is well known as a nongenetic intervention that robustly extends lifespan in a variety of species; however, its underlying mechanisms remain unclear. We have found in Caenorhabditis elegans that dietary deprivation (DD) during adulthood, defined as removal of their food source Escherichia coli after the completion of larval development, increased lifespan and enhanced thermotolerance and resistance to oxidative stress. DD-induced longevity was independent of one C. elegans SIRTUIN, sir-2.1, which is required for the effects of DR, and was independent of the daf-2/insulin-like signaling pathway that independently regulates longevity and larval diapause in C. elegans. DD did not significantly alter lifespan of fem-1(hc17); eat-2(ad465) worms, a genetic model of DR. These findings suggest that DD and DR share some downstream effectors. In addition, DD was detrimental for longevity when imposed on reproductively active young adults, suggesting that DD may only be beneficial in the absence of competing metabolic demands, such as fertility. Adult-onset DD offers a new paradigm for investigating dietary regulation of longevity in C. elegans. This study presents the first evidence that long-term DD, instead of being detrimental, can extend lifespan of a multicellular adult organism. JF - Aging Cell AU - Lee, Garrick D AU - Wilson, Mark A AU - Zhu, Min AU - Wolkow, Catherine A AU - de Cabo, Rafael AU - Ingram, Donald K AU - Zou, Sige AD - Laboratory of Experimental Gerontology, zous@grc.nia.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 515 EP - 524 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 5 IS - 6 SN - 1474-9718, 1474-9718 KW - Microbiology Abstracts B: Bacteriology KW - Fertility KW - Dietary restrictions KW - Life span KW - Aging KW - Sirtuins KW - Longevity KW - Oxidative stress KW - Food sources KW - Caenorhabditis elegans KW - Escherichia coli KW - Diapause KW - Signal transduction KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19775294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aging+Cell&rft.atitle=Dietary+deprivation+extends+lifespan+in+Caenorhabditis+elegans&rft.au=Lee%2C+Garrick+D%3BWilson%2C+Mark+A%3BZhu%2C+Min%3BWolkow%2C+Catherine+A%3Bde+Cabo%2C+Rafael%3BIngram%2C+Donald+K%3BZou%2C+Sige&rft.aulast=Lee&rft.aufirst=Garrick&rft.date=2006-12-01&rft.volume=5&rft.issue=6&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Aging+Cell&rft.issn=14749718&rft_id=info:doi/10.1111%2Fj.1474-9726.2006.00241.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - SuppNotes - Figures, 6; tables, 3; references, 55. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Fertility; Oxidative stress; Dietary restrictions; Food sources; Aging; Life span; Sirtuins; Diapause; Longevity; Signal transduction; Caenorhabditis elegans; Escherichia coli DO - http://dx.doi.org/10.1111/j.1474-9726.2006.00241.x ER - TY - JOUR T1 - Implications of High-Risk Family Studies for Prevention of Depression AN - 19752416; 8791158 AB - The high-risk family study is a powerful design that facilitates identification of early forms of expression of depression and premorbid vulnerability, risk, and protective factors that are important for defining prevention targets and program foci. This paper (1) highlights the strengths of high-risk studies for informing early intervention efforts; (2) summarizes findings of familial aggregation from controlled high-risk studies of depression; and (3) briefly reviews evidence for potential mediators (i.e., early forms of expression, vulnerability factors) that explain familial risk and for moderators (i.e., interactive risk and protective factors) that enhance or minimize familial risk. New data from the Yale High-Risk Study of Comorbidity of Substance Use and Affective Disorders are presented to exemplify strategies for identifying specific familial pathways to depression among offspring of parents with substance and anxiety disorders. Likewise, parental depression is associated with a range of emotional and behavioral problems, including anxiety and conduct disorder, in their offspring. These nonspecific effects, together with emerging findings on mechanisms of risk, support early intervention efforts that target a range of youth at risk for depression through multipronged approaches that attend to the individual characteristics of the child and parent, clinical comorbidity, and the broader family and social context. JF - American Journal of Preventive Medicine AU - Avenevoli, Shelli AU - Merikangas, Kathleen Ries AD - Division of Pediatric Translational Research and Treatment Development, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, shelli.avenevoli@nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 126 EP - 135 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 31 IS - 6 SN - 0749-3797, 0749-3797 KW - Risk Abstracts KW - substance use KW - depression KW - Morbidity KW - Family studies KW - Reviews KW - intervention KW - prevention KW - vulnerability KW - offspring KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19752416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Implications+of+High-Risk+Family+Studies+for+Prevention+of+Depression&rft.au=Avenevoli%2C+Shelli%3BMerikangas%2C+Kathleen+Ries&rft.aulast=Avenevoli&rft.aufirst=Shelli&rft.date=2006-12-01&rft.volume=31&rft.issue=6&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2006.07.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - depression; offspring; prevention; vulnerability; intervention; Morbidity; Reviews; Family studies; substance use DO - http://dx.doi.org/10.1016/j.amepre.2006.07.003 ER - TY - JOUR T1 - Weight, Height, and Body Mass Index and Risk for Ovarian Cancer in a Cohort Study AN - 19597134; 7262407 AB - PURPOSE: Reported associations between ovarian cancer and body size are inconsistent. We assessed ovarian cancer and anthropometry in the Breast Cancer Detection Demonstration Project Follow-Up Study. METHODS: The 46,026 participants completed a baseline interview and mailed questionnaires between 1979 and 1998. By using multiple sources, we identified 346 incident ovarian cancers during follow-up. We calculated rate ratios (RRs) and 95% confidence intervals (CIs) to estimate relative risks for developing ovarian cancer associated with height and weight (measured 1973 to 1980) and self-reported current and usual adult weight (collected during follow-up). RESULTS: Neither taller height (3 greater than or equal to 66 versus <62 inches; RR, 0.90; 95% CI, 0.64-1.26) nor greater weight ( greater than or equal to 161 versus less than or equal to 120 lbs; RR, 1.09; 95% CI, 0.77-1.55) was associated with ovarian cancer. Compared with normal weight (body mass index [BMI], 18.5 to 24.9 kg/m super(2)), overweight (BMI, 25 to 29.9 kg/m super(2); RR, 1.00; 95% CI, 0.78-1.29) and obesity (BMI, 30 to 34.9 kg/m super(2); RR, 0.94; 95% CI, 0.59-1.48) were not associated with ovarian cancer. Severe obesity (BMI greater than or equal to 35 kg/m super(2)) produced a nonsignificantly elevated RR (1.55; 95% CI, 0.84-2.84). Associations with histologic types and statistical interactions with menopausal status and hormone therapy use were null. CONCLUSIONS: Based on height and weight measured before baseline, overweight and obesity were not significantly associated with ovarian cancer in this cohort. JF - Annals of Epidemiology AU - Lacey, JV Jr AU - Leitzmann, M AU - Brinton, LA AU - Lubin, J H AU - Sherman, ME AU - Schatzkin, A AU - Schairer, C AD - National Cancer Institute, Division of Epidemiology and Genetics, 6120 Executive Blvd, MSC 7234, Rockville, MD 20852-7234, USA, jimlacey@nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 869 EP - 876 VL - 16 IS - 12 SN - 1047-2797, 1047-2797 KW - ovarian carcinoma KW - Risk Abstracts; Health & Safety Science Abstracts KW - body mass KW - obesity KW - Females KW - Hormones KW - Cancer KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19597134?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+Epidemiology&rft.atitle=Weight%2C+Height%2C+and+Body+Mass+Index+and+Risk+for+Ovarian+Cancer+in+a+Cohort+Study&rft.au=Lacey%2C+JV+Jr%3BLeitzmann%2C+M%3BBrinton%2C+LA%3BLubin%2C+J+H%3BSherman%2C+ME%3BSchatzkin%2C+A%3BSchairer%2C+C&rft.aulast=Lacey&rft.aufirst=JV&rft.date=2006-12-01&rft.volume=16&rft.issue=12&rft.spage=869&rft.isbn=&rft.btitle=&rft.title=Annals+of+Epidemiology&rft.issn=10472797&rft_id=info:doi/10.1016%2Fj.annepidem.2006.07.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - body mass; obesity; Females; Hormones; Cancer DO - http://dx.doi.org/10.1016/j.annepidem.2006.07.011 ER - TY - JOUR T1 - Association Between Hormones and Metabolic Syndrome in Older Italian Men AN - 19561087; 7228131 AB - OBJECTIVES: To determine whether low levels of testosterone, sex hormone binding globulin (SHBG), insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone sulfate (DHEAS) and high levels of cortisol and leptin would be associated with metabolic syndrome (MS). DESIGN: Cross-sectional. SETTING: Population-based sample of older Italian men. PARTICIPANTS: Four hundred fifty-two men aged 65 and older enrolled in the Invecchiare in Chianti (InCHIANTI) study. MEASUREMENTS: Complete data on testosterone, cortisol, DHEAS, SHBG, fasting insulin, IGF-1 and leptin. MS was defined according to Adult Treatment Panel III criteria. RESULTS: MS was present in 73 men (15.8% of the sample). After adjusting for confounders, total testosterone (P<.05) and log (SHBG) (P<.001) were inversely associated, whereas log (leptin) was positively associated with MS (P<.001). Independent of age, log (SHBG) was positively associated with high-density lipoprotein cholesterol (P<.05) and negatively associated with abdominal obesity (P<.001) and triglycerides (P<.001). Log (leptin) was significantly associated with each component of MS. Cortisol, DHEAS, free and bioavailable testosterone, and IGF-1 were not associated with MS. Having three or more hormones in the lower (for hormones lower in MS) or the upper (for hormones higher in MS) quartile was associated with three times the risk of being affected by MS (odds ratio=2.8, 95% confidence interval=1.3-6.9) (P=.005), compared with not having this condition. CONCLUSION: Total testosterone and SHBG are negatively and leptin is positively associated with MS in older men. Whether specific patterns of hormonal dysregulation predict the development of MS should be tested in longitudinal studies. JF - Journal of the American Geriatrics Society AU - Maggio, Marcello AU - Lauretani, Fulvio AU - Ceda, Gian Paolo AU - Bandinelli, Stefania AU - Basaria, Shehzad AU - Ble, Alessandro AU - Egan, Josephine AU - Paolisso, Giuseppe AU - Najjar, Samer AU - Jeffrey Metter, E AU - Valenti, Giorgio AU - Guralnik, Jack M AU - Ferrucci, Luigi AD - Marcello Maggio, MD, PhD, National Institute on Aging, NIH, NIA-ASTRA Unit at Harbor Hospital, 3001 S. Hanover Street, Baltimore, MD 21225, maggiom@grc.nia.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1832 EP - 1838 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 54 IS - 12 SN - 0002-8614, 0002-8614 KW - Risk Abstracts KW - Sulfates KW - Bioavailability KW - obesity KW - males KW - Hormones KW - longitudinal studies KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19561087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Geriatrics+Society&rft.atitle=Association+Between+Hormones+and+Metabolic+Syndrome+in+Older+Italian+Men&rft.au=Maggio%2C+Marcello%3BLauretani%2C+Fulvio%3BCeda%2C+Gian+Paolo%3BBandinelli%2C+Stefania%3BBasaria%2C+Shehzad%3BBle%2C+Alessandro%3BEgan%2C+Josephine%3BPaolisso%2C+Giuseppe%3BNajjar%2C+Samer%3BJeffrey+Metter%2C+E%3BValenti%2C+Giorgio%3BGuralnik%2C+Jack+M%3BFerrucci%2C+Luigi&rft.aulast=Maggio&rft.aufirst=Marcello&rft.date=2006-12-01&rft.volume=54&rft.issue=12&rft.spage=1832&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Geriatrics+Society&rft.issn=00028614&rft_id=info:doi/10.1111%2Fj.1532-5415.2006.00963.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 2; tables, 3; references, 37. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sulfates; Bioavailability; obesity; males; Hormones; longitudinal studies DO - http://dx.doi.org/10.1111/j.1532-5415.2006.00963.x ER - TY - JOUR T1 - Statistical Analysis for Haplotype-Based Matched Case-Control Studies AN - 19559136; 7215166 AB - Using unphased genotype data, we studied statistical inference for association between a disease and a haplotype in matched case-control studies. Statistical inference for haplotype data is complicated due to ambiguity of genotype phases. An estimating equation-based method is developed for estimating odds ratios and testing disease-haplotype association. The method potentially can also be applied to testing haplotype-environment interaction. Simulation studies show that the proposed method has good performance. The performance of the method in the presence of departures from Hardy-Weinberg equilibrium is also studied. JF - Biometrics AU - Zhang, H AU - Zheng, G AU - Li, Z AD - Department of Statistics, George Washington University, 2140 Pennsylvania Avenue NW, Washington, DC 20052, U.S.A. Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, 6120 Executive Boulevard, EPS, Bethesda, Maryland 20892, U.S.A, zli@gwu.edu Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1124 EP - 1131 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 62 IS - 4 SN - 0006-341X, 0006-341X KW - Biotechnology and Bioengineering Abstracts KW - Haplotypes KW - Statistical analysis KW - Biometrics KW - Genotypes KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19559136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrics&rft.atitle=Statistical+Analysis+for+Haplotype-Based+Matched+Case-Control+Studies&rft.au=Zhang%2C+H%3BZheng%2C+G%3BLi%2C+Z&rft.aulast=Zhang&rft.aufirst=H&rft.date=2006-12-01&rft.volume=62&rft.issue=4&rft.spage=1124&rft.isbn=&rft.btitle=&rft.title=Biometrics&rft.issn=0006341X&rft_id=info:doi/10.1111%2Fj.1541-0420.2006.00568.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - SuppNotes - Tables, 5; formulas, 81; references, 38. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Haplotypes; Genotypes; Biometrics; Statistical analysis DO - http://dx.doi.org/10.1111/j.1541-0420.2006.00568.x ER - TY - JOUR T1 - IHF-dependent activation of P1 plasmid origin by DnaA AN - 19556927; 7220164 AB - In bacteria, many DNA-protein interactions that initiate transcription, replication and recombination require the mediation of DNA architectural proteins such as IHF and HU. For replication initiation, plasmid P1 requires three origin binding proteins: the architectural protein HU, a plasmid-specific initiator, RepA, and the Escherichia coli chromosomal initiator, DnaA. The two initiators bind in the origin of replication to multiple sites, called iterons and DnaA boxes respectively. We show here that all five known DnaA boxes can be deleted from the plasmid origin provided the origin is extended by about 120 bp. The additional DNA provides an IHF site and most likely a weak DnaA binding site, because replacing the putative site with an authentic DnaA box enhanced plasmid replication in an IHF-dependent manner. IHF most likely brings about interactions between distally bound DnaA and RepA by bending the intervening DNA. The role of IHF in activating P1 origin by allowing DnaA binding to a weak site is reminiscent of the role the protein plays in initiating the host chromosomal replication. JF - Molecular Microbiology AU - Fekete, Richard A AU - Venkova-Canova, Tatiana AU - Park, Kyusung AU - Chattoraj, Dhruba K Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1739 EP - 1751 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 62 IS - 6 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Recombination KW - Replication initiation KW - Replication KW - Escherichia coli KW - DNA KW - Replication origins KW - Transcription KW - Plasmids KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19556927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=IHF-dependent+activation+of+P1+plasmid+origin+by+DnaA&rft.au=Fekete%2C+Richard+A%3BVenkova-Canova%2C+Tatiana%3BPark%2C+Kyusung%3BChattoraj%2C+Dhruba+K&rft.aulast=Fekete&rft.aufirst=Richard&rft.date=2006-12-01&rft.volume=62&rft.issue=6&rft.spage=1739&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05479.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 6; tables, 2; references, 52. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Recombination; Replication initiation; Replication; Replication origins; DNA; Transcription; Plasmids; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05479.x ER - TY - JOUR T1 - Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging AN - 19522205; 7210567 AB - The plasma membrane (PM) contains redox enzymes that provide electrons for energy metabolism and recycling of antioxidants such as coenzyme Q and alpha -tocopherol. Brain aging and neurodegenerative disorders involve impaired energy metabolism and oxidative damage, but the involvement of the PM redox system (PMRS) in these processes is unknown. Caloric restriction (CR), a manipulation that protects the brain against aging and disease, increased activities of PMRS enzymes (NADH-ascorbate free radical reductase, NADH-quinone oxidoreductase 1, NADH-ferrocyanide reductase, NADH-coenzyme Q10 reductase, and NADH-cytochrome c reductase) and antioxidant levels ( alpha -tocopherol and coenzyme Q10) in brain PM during aging. Age-related increases in PM lipid peroxidation, protein carbonyls, and nitrotyrosine were attenuated by CR, levels of PMRS enzyme activities were higher, and markers of oxidative stress were lower in cultured neuronal cells treated with CR serum compared with those treated with ad libitum serum. These findings suggest important roles for the PMRS in protecting brain cells against age-related increases in oxidative and metabolic stress. JF - Proceedings of the National Academy of Sciences, USA AU - Hyun, Dong-Hoon AU - Emerson, Scott S AU - Jo, Dong-Gyu AU - Mattson, Mark P AU - de Cabo, Rafael AD - Laboratory of Neurosciences and Laboratory of Experimental Gerontology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 19908 EP - 19912 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 52 SN - 0027-8424, 0027-8424 KW - Sustainability Science Abstracts; CSA Neurosciences Abstracts KW - nitrotyrosine KW - Antioxidants KW - Lipids KW - Aging KW - Recycling KW - Waste management KW - Coenzyme Q10 KW - Plasma membranes KW - Oxidative stress KW - coenzyme Q KW - aging KW - Membranes KW - NADH-quinone oxidoreductase KW - Energy metabolism KW - Dietary restrictions KW - Free radicals KW - Brain KW - Stress KW - Enzymes KW - peroxidation KW - Lipid peroxidation KW - Neurodegenerative diseases KW - Vitamin E KW - Nutrient deficiency KW - carbonyls KW - Metabolism KW - M3 1010:Issues in Sustainable Development KW - N3 11008:Neurochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Calorie+restriction+up-regulates+the+plasma+membrane+redox+system+in+brain+cells+and+suppresses+oxidative+stress+during+aging&rft.au=Hyun%2C+Dong-Hoon%3BEmerson%2C+Scott+S%3BJo%2C+Dong-Gyu%3BMattson%2C+Mark+P%3Bde+Cabo%2C+Rafael&rft.aulast=Hyun&rft.aufirst=Dong-Hoon&rft.date=2006-12-01&rft.volume=103&rft.issue=52&rft.spage=19908&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antioxidants; NADH-quinone oxidoreductase; nitrotyrosine; Energy metabolism; Dietary restrictions; Free radicals; Aging; Brain; Recycling; Lipid peroxidation; Coenzyme Q10; Neurodegenerative diseases; Nutrient deficiency; Vitamin E; Plasma membranes; Oxidative stress; coenzyme Q; carbonyls; Membranes; Lipids; Enzymes; Stress; peroxidation; Metabolism; Waste management; aging ER - TY - JOUR T1 - Proinflammatory and Antimicrobial Nitric Oxide in Gingival Fluid of Diabetic Patients with Periodontal Disease AN - 19519773; 7192791 AB - Abnormal nitric oxide (NO) synthesis has been implicated in the pathogenesis of both periodontal disease and diabetes mellitus. In diabetic patients, increased inducible NO synthase in inflamed gingiva correlated with NO in gingival crevicular fluid. Although increased NO reflected more-severe inflammation, it was associated with reductions in CFU of Prevotella intermedia, a major periodontopathogen, highlighting dual roles for NO. JF - Infection and Immunity AU - Skaleric, Uros AU - Gaspirc, Boris AU - McCartney-Francis, Nancy AU - Masera, Andrej AU - Wahl, Sharon M AD - Department of Oral Medicine & Periodontology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. Oral Infection & Immunity Branch, NIDCR, NIH, Bethesda, Maryland. Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 7010 EP - 7013 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 12 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Diabetes mellitus KW - Periodontal diseases KW - Nitric-oxide synthase KW - Colony-forming cells KW - Gingiva KW - Prevotella intermedia KW - Nitric oxide KW - Inflammation KW - A 01340:Antibiotics & Antimicrobials KW - F 06930:Autoimmunity KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19519773?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Proinflammatory+and+Antimicrobial+Nitric+Oxide+in+Gingival+Fluid+of+Diabetic+Patients+with+Periodontal+Disease&rft.au=Skaleric%2C+Uros%3BGaspirc%2C+Boris%3BMcCartney-Francis%2C+Nancy%3BMasera%2C+Andrej%3BWahl%2C+Sharon+M&rft.aulast=Skaleric&rft.aufirst=Uros&rft.date=2006-12-01&rft.volume=74&rft.issue=12&rft.spage=7010&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Nitric-oxide synthase; Periodontal diseases; Diabetes mellitus; Colony-forming cells; Gingiva; Nitric oxide; Inflammation; Prevotella intermedia ER - TY - JOUR T1 - Kinase Activity of Overexpressed HipA Is Required for Growth Arrest and Multidrug Tolerance in Escherichia coli AN - 19518406; 7207892 AB - Overexpression of the HipA protein of the HipBA toxin/antitoxin module leads to multidrug tolerance in Escherichia coli. HipA is a "toxin" that causes reversible dormancy, whereas HipB is an antitoxin that binds HipA and acts as a transcriptional repressor of the hipBA operon. Comparative sequence analysis shows that HipA is a member of the phosphatidylinositol 3/4-kinase superfamily. The kinase activity of HipA was examined. HipA was autophosphorylated in the presence of ATP in vitro, and the purified protein appeared to carry a single phosphate group on serine 150. Thus, HipA is a serine kinase that is at least partially phosphorylated in vivo. Overexpression of HipA caused inhibition of cell growth and increase in persister formation. Replacing conserved aspartate 309 in the conserved kinase active site or aspartate 332 in the Mg super(2+)-binding site with glutamine produced mutant proteins that lost the ability to stop cellular growth upon overexpression. Replacing serine 150 with alanine yielded a similarly inactive protein. The mutant proteins were then examined for their ability to increase antibiotic tolerance. Cells overexpressing wild-type HipA were highly tolerant to cefotaxime, a cell wall synthesis inhibitor, to ofloxacin, a fluoroquinolone inhibitor of DNA gyrase, and to topoisomerase IV and were almost completely resistant to killing by mitomycin C, which forms DNA adducts. The mutant proteins did not protect cells from cefotaxime or ofloxacin and had an impaired ability to protect from mitomycin C. Taken together, these results suggest that the protein kinase activity of HipA is essential for persister formation. JF - Journal of Bacteriology AU - Correia, Frederick F AU - D'Onofrio, Anthony AU - Rejtar, Tomas AU - Li, Lingyun AU - Karger, Barry L AU - Makarova, Kira AU - Koonin, Eugene V AU - Lewis, Kim AD - Department of Biology and Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts 02115. Barnett Institute and Department of Chemistry, Northeastern University, Boston, Massachusetts 02115. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 8360 EP - 8367 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Antitoxins KW - DNA adducts KW - Glutamine KW - protein-serine kinase KW - Cefotaxime KW - Fluoroquinolones KW - Alanine KW - Ofloxacin KW - DNA topoisomerase KW - Transcription KW - ATP KW - Mitomycin C KW - DNA topoisomerase IV KW - Toxins KW - Antibiotic tolerance KW - Phosphate KW - Escherichia coli KW - Protein kinase KW - Operons KW - Dormancy KW - Repressors KW - Cell walls KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19518406?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Kinase+Activity+of+Overexpressed+HipA+Is+Required+for+Growth+Arrest+and+Multidrug+Tolerance+in+Escherichia+coli&rft.au=Correia%2C+Frederick+F%3BD%27Onofrio%2C+Anthony%3BRejtar%2C+Tomas%3BLi%2C+Lingyun%3BKarger%2C+Barry+L%3BMakarova%2C+Kira%3BKoonin%2C+Eugene+V%3BLewis%2C+Kim&rft.aulast=Correia&rft.aufirst=Frederick&rft.date=2006-12-01&rft.volume=188&rft.issue=24&rft.spage=8360&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antitoxins; DNA adducts; Glutamine; Cefotaxime; protein-serine kinase; Alanine; Fluoroquinolones; Ofloxacin; DNA topoisomerase; ATP; Transcription; Mitomycin C; Toxins; DNA topoisomerase IV; Antibiotic tolerance; Phosphate; Protein kinase; Dormancy; Operons; Repressors; Cell walls; Escherichia coli ER - TY - JOUR T1 - Characterization of the B Cell Epitopes Associated with a Truncated Form of Pseudomonas Exotoxin (PE38) Used to Make Immunotoxins for the Treatment of Cancer Patients AN - 19517027; 7208948 AB - Recombinant immunotoxins composed of an Ab Fv fragment joined to a truncated portion of Pseudomonas exotoxin A (termed PE38) have been evaluated in clinical trials for the treatment of various human cancers. Immunotoxin therapy is very effective in hairy cell leukemia and also has activity in other hemological malignancies; however, a neutralizing Ab response to PE38 in patients with solid tumors prevents repeated treatments to maximize the benefit. In this study, we analyze the murine Ab response as a model to study the B cell epitopes associated with PE38. Sixty distinct mAbs to PE38 were characterized. Mutual competitive binding of the mAbs indicated the presence of 7 major epitope groups and 13 subgroups. The competition pattern indicated that the epitopes are discrete and could not be reproduced using a computer simulation program that created epitopes out of random surface residues on PE38. Using sera from immunotoxin-treated patients, the formation of human Abs to each of the topographical epitopes was demonstrated. One epitope subgroup, E1a, was identified as the principal neutralizing epitope. The location of each epitope on PE38 was determined by preparing 41 mutants of PE38 in which bulky surface residues were mutated to either alanine or glycine. All 7 major epitope groups and 9 of 13 epitope subgroups were identified by 14 different mutants and these retained high cytotoxic activity. Our results indicate that a relatively small number of discrete immunogenic sites are associated with PE38, most of which can be eliminated by point mutations. JF - Journal of Immunology AU - Onda, Masanori AU - Nagata, Satoshi AU - FitzGerald, David J AU - Beers, Richard AU - Fisher, Robert J AU - Vincent, James J AU - Lee, Byungkook AU - Nakamura, Michihiro AU - Hwang, Jaulang AU - Kreitman, Robert J AU - Hassan, Raffit AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892. Protein Chemistry Laboratory, Research Technology Program, Science Applications International Corporation, National Cancer Institute, Frederick, MD 21702 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 8822 EP - 8834 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 12 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Mathematical models KW - Alanine KW - Solid tumors KW - Lymphocytes B KW - Monoclonal antibodies KW - Glycine KW - Point mutation KW - Animal models KW - Pseudomonas KW - Antibody response KW - exotoxin A KW - Clinical trials KW - Cancer KW - Fv KW - Immunotoxins KW - Exotoxins KW - Antibodies KW - Cytotoxicity KW - Malignancy KW - Hairy cell leukemia KW - Epitopes KW - F 06915:Cancer Immunology KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19517027?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Characterization+of+the+B+Cell+Epitopes+Associated+with+a+Truncated+Form+of+Pseudomonas+Exotoxin+%28PE38%29+Used+to+Make+Immunotoxins+for+the+Treatment+of+Cancer+Patients&rft.au=Onda%2C+Masanori%3BNagata%2C+Satoshi%3BFitzGerald%2C+David+J%3BBeers%2C+Richard%3BFisher%2C+Robert+J%3BVincent%2C+James+J%3BLee%2C+Byungkook%3BNakamura%2C+Michihiro%3BHwang%2C+Jaulang%3BKreitman%2C+Robert+J%3BHassan%2C+Raffit%3BPastan%2C+Ira&rft.aulast=Onda&rft.aufirst=Masanori&rft.date=2006-12-01&rft.volume=177&rft.issue=12&rft.spage=8822&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Mathematical models; Alanine; Glycine; Monoclonal antibodies; Lymphocytes B; Solid tumors; Point mutation; Animal models; Antibody response; Clinical trials; exotoxin A; Exotoxins; Immunotoxins; Fv; Cancer; Malignancy; Cytotoxicity; Antibodies; Hairy cell leukemia; Epitopes; Pseudomonas ER - TY - JOUR T1 - Higher Self-reported Physical Activity Is Associated With Lower Systolic Blood Pressure: The Dietary Intervention Study in Childhood (DISC) AN - 19515956; 7210149 AB - OBJECTIVE. Children participating in a dietary clinical trial were studied to (1) assess physical activity patterns in boys and girls longitudinally from late childhood through puberty and (2) determine the association of level of physical activity on systolic blood pressure, low-density lipoprotein cholesterol, and BMI. PATIENTS AND METHODS. In the Dietary Intervention Study in Childhood, a randomized clinical trial of a reduced saturated fat and cholesterol diet in 8- to 10-year-olds with elevated low-density lipoprotein, a questionnaire that determined time spent in 5 intensity levels of physical activity was completed at baseline and at 1 and 3 years. An estimated-metabolic-equivalent score was calculated for weekly activity; hours per week were calculated for intense activities. We hypothesized that weekly self-reported physical activity would be associated with lower systolic blood pressure, low-density lipoprotein, and BMI over 3 years. Longitudinal data analyses were performed for each outcome (systolic blood pressure, low-density lipoprotein, and BMI) by using generalized estimating equations with estimated-metabolic-equivalent score per week as the independent variable adjusted for visit, gender, and Tanner stage (BMI was included in models for systolic blood pressure and low-density lipoprotein). RESULTS. The initial study cohort comprised 663 youths (362 boys [mean age: 9.7 years] and 301 girls [mean age: 9.0 years), of whom 623 (94%) completed the 3-year visit. For every 100 estimated-metabolic-equivalent hours of physical activity, there was a decrease of 1.15 mmHg of systolic blood pressure. There was a 1.28 mg/dL decline in low-density lipoprotein for a similar energy expenditure. For BMI, an analysis of intense physical activity showed that for every 10 hours of intense activity, there was a trend toward significance with a 0.2 kg/m super(2) decrease. CONCLUSIONS. Children with elevated cholesterol levels who lead a more physically active lifestyle have lower systolic blood pressure and a trend toward lower low-density lipoprotein over a 3-year interval. Long-term participation in intense physical activity may reduce BMI as well. JF - Pediatrics AU - Gidding, Samuel S AU - Barton, Bruce A AU - Dorgan, Joanne A AU - Kimm, Sue YS AU - Kwiterovich, Peter O AU - Lasser, Normal L AU - Robson, Alan M AU - Stevens, Victor J AU - Van Horn, Linda AU - Simons-Morton, Denise G AD - Nemours Cardiac Center, A.I. duPont Children's Hospital and Thomas Jefferson University, Wilmington, Delaware. Maryland Medical Research Institute, Baltimore, Maryland. Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania. Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland. Department of Internal Medicine, New Jersey Medical School, Newark, New Jersey. Department of Nephrology, Children's Hospital, New Orleans, Louisiana. Kaiser-Permanente Center for Health Research, Portland, Oregon. Department of Preventive Medicine, Northwestern University Medical School, Chicago, Illinois. National Heart, Lung, and Blood Institute, Bethesda, Maryland Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2388 EP - 2393 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 118 IS - 6 SN - 0031-4005, 0031-4005 KW - Physical Education Index KW - Age KW - Boys KW - Pediatrics KW - Lipids KW - Surveys KW - Patients KW - Exercise KW - Children KW - Blood pressure KW - Lifestyle KW - Energy cost KW - Participation KW - Girls KW - Analysis KW - Gender KW - Diet KW - Trends KW - Youth KW - Puberty KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19515956?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Higher+Self-reported+Physical+Activity+Is+Associated+With+Lower+Systolic+Blood+Pressure%3A+The+Dietary+Intervention+Study+in+Childhood+%28DISC%29&rft.au=Gidding%2C+Samuel+S%3BBarton%2C+Bruce+A%3BDorgan%2C+Joanne+A%3BKimm%2C+Sue+YS%3BKwiterovich%2C+Peter+O%3BLasser%2C+Normal+L%3BRobson%2C+Alan+M%3BStevens%2C+Victor+J%3BVan+Horn%2C+Linda%3BSimons-Morton%2C+Denise+G&rft.aulast=Gidding&rft.aufirst=Samuel&rft.date=2006-12-01&rft.volume=118&rft.issue=6&rft.spage=2388&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Age; Pediatrics; Boys; Lipids; Surveys; Patients; Exercise; Children; Blood pressure; Lifestyle; Energy cost; Participation; Analysis; Girls; Gender; Diet; Trends; Youth; Puberty ER - TY - JOUR T1 - Lead, Genetic Susceptibility, and Risk of Adult Brain Tumors AN - 19514970; 7206759 AB - Background: Although few etiologic factors for brain tumors have been identified, limited data suggest that lead may increase the risk of brain tumors, particularly meningioma. The ALAD G177C polymorphism affects the toxicokinetics of lead and may confer genetic susceptibility to adverse effects of lead exposure. Methods: We examined occupational exposure to lead and risk of brain tumors in a multisite, hospital-based, case-control study of 489 patients with glioma, 197 with meningioma, and 799 non-cancer controls frequency matched on hospital, age, sex, race/ethnicity, and residential proximity to hospital. ALAD genotype was assessed by a Taqman assay for 355 glioma patients, 151 meningioma patients, and 505 controls. Exposure to lead was estimated using a rigorous questionnaire-based exposure assessment strategy incorporating lead measurement and other occupational data abstracted from published articles and reports. Results: Increased risk of meningioma with occupational lead exposure (estimated by odds ratios and 95% confidence intervals) was most apparent in individuals with the ALAD2 variant allele, for whom risk increased from 1.1 (0.3-4.5) to 5.6 (0.7-45.5) and 12.8 (1.4-120.8) for estimated cumulative lead exposures of 1 to 49 mu g/m super(3)-y, 50 to 99 mu g/m super(3)-y, and greater than or equal to 100 mu g/m super(3)-y, respectively, compared with unexposed individuals (two-sided P trend = 0.06). This relationship became stronger after excluding occupational lead exposures characterized by a low confidence level or occurring in the 10 years before meningioma diagnosis. Occupational lead exposure was not associated with glioma risk. Conclusions: Although our results indicate that lead may be implicated in meningioma risk in genetically susceptible individuals, these results need to be interpreted with caution given the small numbers of exposed cases with a variant genotype. (Cancer Epidemiol Biomarkers Prev 2006; 15(12):2514-20) JF - Cancer Epidemiology, Biomarkers & Prevention AU - Rajaraman, Preetha AU - Stewart, Patricia A AU - Samet, Jonathan M AU - Schwartz, Brian S AU - Linet, Martha S AU - Zahm, Shelia Hoar AU - Rothman, Nathaniel AU - Yeager, Meredith AU - Fine, Howard A AU - Black, Peter M AU - Loeffler, Jay AU - Shapiro, William R AU - Selker, Robert G AU - Inskip, Peter D AD - Division of Cancer Epidemiology and Genetics, Core Genotyping Facility, and Neuro-Oncology Branch, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2514 EP - 2520 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 15 IS - 12 SN - 1055-9965, 1055-9965 KW - Genetics Abstracts; Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts; CSA Neurosciences Abstracts KW - Bioindicators KW - Heavy metals KW - Gene polymorphism KW - Genotypes KW - biomarkers KW - Cancer KW - Lead KW - Brain tumors KW - prevention KW - Glioma KW - brain tumors KW - Ethnic groups KW - Occupational exposure KW - meningioma KW - Side effects KW - Hospitals KW - G 07880:Human Genetics KW - N3 11023:Neurogenetics KW - H 11000:Diseases/Injuries/Trauma KW - X 24360:Metals KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19514970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.atitle=Lead%2C+Genetic+Susceptibility%2C+and+Risk+of+Adult+Brain+Tumors&rft.au=Rajaraman%2C+Preetha%3BStewart%2C+Patricia+A%3BSamet%2C+Jonathan+M%3BSchwartz%2C+Brian+S%3BLinet%2C+Martha+S%3BZahm%2C+Shelia+Hoar%3BRothman%2C+Nathaniel%3BYeager%2C+Meredith%3BFine%2C+Howard+A%3BBlack%2C+Peter+M%3BLoeffler%2C+Jay%3BShapiro%2C+William+R%3BSelker%2C+Robert+G%3BInskip%2C+Peter+D&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2006-12-01&rft.volume=15&rft.issue=12&rft.spage=2514&rft.isbn=&rft.btitle=&rft.title=Cancer+Epidemiology%2C+Biomarkers+%26+Prevention&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Brain tumors; Gene polymorphism; Glioma; biomarkers; Side effects; Lead; meningioma; Occupational exposure; Hospitals; Bioindicators; Heavy metals; prevention; Genotypes; brain tumors; Ethnic groups; Cancer ER - TY - JOUR T1 - Specificity of DNA Binding and Dimerization by CspE from Escherichia coli AN - 19509648; 7208318 AB - The CspE protein from Escherichia coli K12 is a single-stranded nucleic acid-binding protein that plays a role in chromosome condensation in vivo. We report here that CspE binds to single-stranded DNA containing 6 or more contiguous dT residues with high affinity (K sub(D) < 30 nM). The interactions are predominantly through base-specific contacts. When an oligonucleotide contains fewer than 6 contiguous dT residues, the CspE interactions with single-stranded DNA are primarily electrostatic. The minimal length of single-stranded DNA to which CspE binds in a salt-resistant manner is eight nucleotides. We also show that CspE exists as a dimer in solution. We present a possible mechanism to explain the role of CspE in chromosome condensation in vivo by CspE binding to distant DNA regions in the chromosome and dimerizing, thereby condensing the intervening DNA. JF - Journal of Biological Chemistry AU - Johnston, Danielle AU - Tavano, Christine AU - Wickner, Sue AU - Trun, Nancy AD - Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282 and the Laboratory of Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20895 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 40208 EP - 40215 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 52 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - CspE protein KW - Chromosomes KW - Escherichia coli KW - Condensation KW - Oligonucleotides KW - Nucleotides KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19509648?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Specificity+of+DNA+Binding+and+Dimerization+by+CspE+from+Escherichia+coli&rft.au=Johnston%2C+Danielle%3BTavano%2C+Christine%3BWickner%2C+Sue%3BTrun%2C+Nancy&rft.aulast=Johnston&rft.aufirst=Danielle&rft.date=2006-12-01&rft.volume=281&rft.issue=52&rft.spage=40208&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - CspE protein; Chromosomes; Condensation; Oligonucleotides; Nucleotides; Escherichia coli ER - TY - JOUR T1 - Escherichia coli RNA Polymerase Recognition of a sigma super(70)-Dependent Promoter Requiring a -35 DNA Element and an Extended -10 TGn Motif AN - 19506215; 7207891 AB - Escherichia coli sigma super(70)-dependent promoters have typically been characterized as either -10/-35 promoters, which have good matches to both the canonical -10 and the -35 sequences or as extended -10 promoters (TGn/-10 promoters), which have the TGn motif and an excellent match to the -10 consensus sequence. We report here an investigation of a promoter, P sub(minor), that has a nearly perfect match to the -35 sequence and has the TGn motif. However, P sub(minor) contains an extremely poor sigma super(70) -10 element. We demonstrate that P sub(minor) is active both in vivo and in vitro and that mutations in either the -35 or the TGn motif eliminate its activity. Mutation of the TGn motif can be compensated for by mutations that make the -10 element more canonical, thus converting the -35/TGn promoter to a -35/-10 promoter. Potassium permanganate footprinting on the nontemplate and template strands indicates that when polymerase is in a stable (open) complex with P sub(minor), the DNA is single stranded from positions -11 to +4. We also demonstrate that transcription from P sub(minor) incorporates nontemplated ribonucleoside triphosphates at the 5' end of the P sub(minor) transcript, which results in an anomalous assignment for the start site when primer extension analysis is used. P sub(minor) represents one of the few -35/TGn promoters that have been characterized and serves as a model for investigating functional differences between these promoters and the better-characterized -10/-35 and extended -10 promoters used by E. coli RNA polymerase. JF - Journal of Bacteriology AU - Hook-Barnard, India AU - Johnson, Xanthia B AU - Hinton, Deborah M AD - Gene Expression and Regulation Section, Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg. 8, Room 2A-13, Bethesda, Maryland 20892-0830 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 8352 EP - 8359 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Promoters KW - DNA-directed RNA polymerase KW - Footprinting KW - Escherichia coli KW - Transcription KW - Conserved sequence KW - potassium permanganate KW - Mutation KW - Models KW - J 02310:Genetics & Taxonomy KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Escherichia+coli+RNA+Polymerase+Recognition+of+a+sigma+super%2870%29-Dependent+Promoter+Requiring+a+-35+DNA+Element+and+an+Extended+-10+TGn+Motif&rft.au=Hook-Barnard%2C+India%3BJohnson%2C+Xanthia+B%3BHinton%2C+Deborah+M&rft.aulast=Hook-Barnard&rft.aufirst=India&rft.date=2006-12-01&rft.volume=188&rft.issue=24&rft.spage=8352&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Promoters; DNA-directed RNA polymerase; Footprinting; Conserved sequence; Transcription; potassium permanganate; Mutation; Models; Escherichia coli ER - TY - JOUR T1 - A public health perspective on research ethics AN - 19506140; 7209679 AB - Ethical guidelines for conducting clinical trials have historically been based on a perceived therapeutic obligation to treat and benefit the patient-participants. The origins of this ethical framework can be traced to the Hippocratic oath originally written to guide doctors in caring for their patients, where the overriding moral obligation of doctors is strictly to do what is best for the individual patient, irrespective of other social considerations. In contrast, although medicine focuses on the health of the person, public health is concerned with the health of the entire population, and thus, public health ethics is founded on the societal responsibility to protect and promote the health of the population as a whole. From a public health perspective, research ethics should be guided by giving due consideration to the risks and benefits to society in addition to the individual research participants. On the basis of a duty to protect the population as a whole, a fiduciary obligation to realise the social value of the research and the moral responsibility to distribute the benefits and burdens of research fairly across society, how a public health perspective on research ethics results in fundamental re-assessments of the proper course of action for two salient topical issues in research ethics is shown: stopping trials early for reasons of efficacy and the conduct of research on less expensive yet less effective interventions. JF - Journal of Medical Ethics AU - Buchanan, D R AU - Miller, F G AD - University of Massachusetts, Amherst, Massachusetts, USA. National Institutes of Health, Bethesda, Maryland, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 729 EP - 733 PB - British Medical Association, BMA House Square Tavistock Square London WC1H 9JP UK, [mailto:info.web@bma.org.uk], [URL:http://www.bma.org.uk/] VL - 32 IS - 12 SN - 0306-6800, 0306-6800 KW - Risk Abstracts KW - social values KW - Historical account KW - guidelines KW - Ethics KW - intervention KW - clinical trials KW - Medical personnel KW - Public health KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Medical+Ethics&rft.atitle=A+public+health+perspective+on+research+ethics&rft.au=Buchanan%2C+D+R%3BMiller%2C+F+G&rft.aulast=Buchanan&rft.aufirst=D&rft.date=2006-12-01&rft.volume=32&rft.issue=12&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+Medical+Ethics&rft.issn=03066800&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Historical account; social values; guidelines; intervention; Ethics; clinical trials; Medical personnel; Public health ER - TY - JOUR T1 - Asbestos Redirects Nitric Oxide Signaling through Rapid Catalytic Conversion to Nitrite AN - 19506007; 7206637 AB - Asbestos exposure is strongly associated with the development of malignant mesothelioma, yet the mechanistic basis of this observation has not been resolved. Carcinogenic transformation or tumor progression mediated by asbestos may be related to the generation of free radical species and perturbation of cell signaling and transcription factors. We report here that exposure of human mesothelioma or lung carcinoma cells to nitric oxide (NO) in the presence of crocidolite asbestos resulted in a marked decrease in intracellular nitrosation and diminished NO-induced posttranslational modifications of tumor-associated proteins (hypoxia-inducible factor-1 alpha and p53). Crocidolite rapidly scavenged NO with concomitant conversion to nitrite (NO sub(2) super(-)). Crocidolite also catalyzed the nitration of cellular proteins in the presence of NO sub(2) super(-) and hydrogen peroxide. Nitrated protein adducts are a prominent feature of asbestos-induced lung injury. These data highlight the ability of asbestos to induce phenotypic cellular changes through two processes: (a) by directly reducing bioactive NO levels and preventing its subsequent interaction with target molecules and (b) by increasing oxidative damage and protein modifications through NO sub(2) production and 3-nitrotyrosine formation. (Cancer Res 2006; 66(24): 11600-4) JF - Cancer Research AU - Thomas, Douglas D AU - Espey, Michael G AU - Pociask, Derek A AU - Ridnour, Lisa A AU - Donzelli, Sonia AU - Wink, David A AD - Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, Maryland and Lung Biology Program, Tulane Medical Center, New Orleans, Louisiana Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 11600 EP - 11604 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 24 SN - 0008-5472, 0008-5472 KW - Toxicology Abstracts KW - Transformation KW - Asbestos KW - nitrotyrosine KW - Injuries KW - Lung carcinoma KW - Free radicals KW - Crocidolite KW - Tumors KW - p53 protein KW - Protein adducts KW - Hydrogen peroxide KW - Transcription factors KW - Nitration KW - mesothelioma KW - Nitric oxide KW - Nitrosation KW - Nitrite KW - Signal transduction KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Asbestos+Redirects+Nitric+Oxide+Signaling+through+Rapid+Catalytic+Conversion+to+Nitrite&rft.au=Thomas%2C+Douglas+D%3BEspey%2C+Michael+G%3BPociask%2C+Derek+A%3BRidnour%2C+Lisa+A%3BDonzelli%2C+Sonia%3BWink%2C+David+A&rft.aulast=Thomas&rft.aufirst=Douglas&rft.date=2006-12-01&rft.volume=66&rft.issue=24&rft.spage=11600&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Asbestos; nitrotyrosine; Injuries; Lung carcinoma; Free radicals; Crocidolite; Tumors; p53 protein; Hydrogen peroxide; Protein adducts; Transcription factors; Nitration; mesothelioma; Nitric oxide; Nitrosation; Nitrite; Signal transduction ER - TY - JOUR T1 - Preconditioning with low concentration NO attenuates subsequent NO-induced apoptosis in vascular smooth muscle cells via HO-1-dependent mitochondrial death pathway AN - 19506006; 7204797 AB - Nitric oxide (NO) signaling pathways are important in both the maintenance of vascular homeostasis and disease progression. Overproduction of NO has been associated with ischemia/reperfusion (I/R) injury. Growing evidences suggest that NO preconditioning has cytoprotective effects against I/R injury. However, the mechanism with which NO mediates these effects remains to be elucidated. The purpose of this study was to examine the mechanism of how NO preconditioning inhibits subsequent NO-induced apoptosis in vascular smooth muscle cells (VSMC), specifically focusing on heme oxygenase-1 (HO-1). According to our data, sodium nitroprusside (SNP) increased HO-1 expression in a concentration dependent manner. Preconditioning with low concentration SNP (0.3mM) inhibited subsequent high concentration SNP (1.5mM)-induced apoptosis, and this effect was reversed by the HO-1 inhibitor SnPP. Low concentration SNP-mediated protection involved p38 kinase inactivation and increased Bcl-2 expression. Furthermore, mitochondrial membrane potential was concomitantly increased with decreased expressions of Bax, Apaf-1, and activity of caspase-3, which was reversed by SnPP treatment. Our results show that low concentration SNP preconditioning suppresses subsequent high concentration SNP-induced apoptosis by inhibiting p38 kinase and mitochondrial death pathway via HO-1-dependent mechanisms in VSMC. JF - Toxicology and Applied Pharmacology AU - Kwak, HJ AU - Park, K M AU - Lee, S AU - Lim, HJ AU - Go, SH AU - Eom, S M AU - Park, HY AD - Center for Biomedical Sciences, National Institutes of Health, Nokbun-dong, Eunpyung-gu, Seoul 122-701, Republic of Korea, hypark65@nih.go.kr Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 176 EP - 184 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 217 IS - 2 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Smooth muscle KW - Apoptosis KW - Injuries KW - Mitochondria KW - Heme oxygenase (decyclizing) KW - sodium nitroprusside KW - Homeostasis KW - Ischemia KW - Reperfusion KW - Bax protein KW - Caspase-3 KW - Nitric oxide KW - Bcl-2 protein KW - Apaf-1 protein KW - Signal transduction KW - Vascular system KW - Membrane potential KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Preconditioning+with+low+concentration+NO+attenuates+subsequent+NO-induced+apoptosis+in+vascular+smooth+muscle+cells+via+HO-1-dependent+mitochondrial+death+pathway&rft.au=Kwak%2C+HJ%3BPark%2C+K+M%3BLee%2C+S%3BLim%2C+HJ%3BGo%2C+SH%3BEom%2C+S+M%3BPark%2C+HY&rft.aulast=Kwak&rft.aufirst=HJ&rft.date=2006-12-01&rft.volume=217&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Smooth muscle; Apoptosis; Injuries; Mitochondria; sodium nitroprusside; Heme oxygenase (decyclizing); Ischemia; Homeostasis; Reperfusion; Bax protein; Caspase-3; Nitric oxide; Bcl-2 protein; Apaf-1 protein; Membrane potential; Vascular system; Signal transduction DO - http://dx.doi.org/10.1016/j.taap.2006.08.010 ER - TY - JOUR T1 - Mutational Analysis To Define an Activating Region on the Redox-Sensitive Transcriptional Regulator OxyR AN - 19505083; 7207889 AB - The OxyR transcription factor is a key regulator of the Escherichia coli response to oxidative stress. Previous studies showed that OxyR binding to a target promoter enhances RNA polymerase binding and vice versa, suggesting a direct interaction between OxyR and RNA polymerase. To identify the region of OxyR that might contact RNA polymerase, we carried out alanine scanning and random mutagenesis of oxyR. The combination of these approaches led to the identification of several mutants defective in the activation of an OxyR target gene. A subset of the mutations map to the DNA-binding domain, other mutations appear to affect dimerization of the regulatory domain, while another group is suggested to affect disulfide bond formation. The two mutations, D142A and R273H, giving the most dramatic phenotype are located in a patch on the surface of the oxidized OxyR protein and possibly define an activating region on OxyR. JF - Journal of Bacteriology AU - Wang, Xunde AU - Mukhopadhyay, Partha AU - Wood, Matthew J AU - Outten, FWayne AU - Opdyke, Jason A AU - Storz, Gisela AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 8335 EP - 8342 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 24 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Promoters KW - DNA-directed RNA polymerase KW - random mutagenesis KW - Alanine KW - Oxidative stress KW - Transcription factors KW - Escherichia coli KW - Disulfide bonds KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19505083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mutational+Analysis+To+Define+an+Activating+Region+on+the+Redox-Sensitive+Transcriptional+Regulator+OxyR&rft.au=Wang%2C+Xunde%3BMukhopadhyay%2C+Partha%3BWood%2C+Matthew+J%3BOutten%2C+FWayne%3BOpdyke%2C+Jason+A%3BStorz%2C+Gisela&rft.aulast=Wang&rft.aufirst=Xunde&rft.date=2006-12-01&rft.volume=188&rft.issue=24&rft.spage=8335&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Promoters; random mutagenesis; DNA-directed RNA polymerase; Alanine; Oxidative stress; Transcription factors; Disulfide bonds; Mutation; Escherichia coli ER - TY - JOUR T1 - Using Rasch modeling to re-evaluate three scales related to physical activity: enjoyment, perceived benefits and perceived barriers AN - 19502810; 7192646 AB - Studies suggest that enjoyment, perceived benefits and perceived barriers may be important mediators of physical activity. However, the psychometric properties of these scales have not been assessed using Rasch modeling. The purpose of this study was to use Rasch modeling to evaluate the properties of three scales commonly used in physical activity studies: the Physical Activity Enjoyment Scale, the Benefits of Physical Activity Scale and the Barriers to Physical Activity Scale. The scales were administered to 378 healthy adults, aged 25-75 years (50% women, 62% Whites), at the baseline assessment for a lifestyle physical activity intervention trial. The ConQuest software was used to assess model fit, item difficulty, item functioning and standard error of measurement. For all scales, the partial credit model fit the data. Item content of one scale did not adequately cover all respondents. Response options of each scale were not targeting respondents appropriately, and standard error of measurement varied across the total score continuum of each scale. These findings indicate that each scale's effectiveness at detecting differences among individuals may be limited unless changes in scale content and response format are made. JF - Health Education Research AU - Heesch, K C AU - Masse, L C AU - Dunn, AL AD - School of Human Movement Studies, University of Queensland, Brisbane, QLD 4072, Australia. Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA. Health Promotion Research Branch, National Cancer Institute, Bethesda, MD 20892, USA. The Cooper Institute, Dallas, TX 75230, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - i58 EP - i72 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 SN - 0268-1153, 0268-1153 KW - Physical Education Index KW - Evaluation KW - Measurement KW - Barriers KW - Computers KW - Women KW - Health KW - Exercise KW - Adults KW - Modeling KW - Lifestyle KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19502810?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+Research&rft.atitle=Using+Rasch+modeling+to+re-evaluate+three+scales+related+to+physical+activity%3A+enjoyment%2C+perceived+benefits+and+perceived+barriers&rft.au=Heesch%2C+K+C%3BMasse%2C+L+C%3BDunn%2C+AL&rft.aulast=Heesch&rft.aufirst=K&rft.date=2006-12-01&rft.volume=21&rft.issue=&rft.spage=i58&rft.isbn=&rft.btitle=&rft.title=Health+Education+Research&rft.issn=02681153&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Evaluation; Measurement; Barriers; Computers; Women; Health; Adults; Exercise; Modeling; Lifestyle ER - TY - JOUR T1 - The Forum Theatre of Augusto Boal: A Dramatic Model for Dialogue and Community-Based Environmental Science AN - 19502755; 7196192 AB - Community oriented environmental science combines the inclusive, action-oriented goals of environmental justice communities and the rationalist methodologies of science in an effort to balance urgent social and physical needs with research protocols, precise analysis and carefully measured conclusions. Community-based participatory research acknowledges that local expertise and networks, adverse social and economic consequences of environmental degradation and community beliefs and attitudes are vital factors that affect both overall community health and research outcomes. A unique CBPR approach to inclusive outreach and education is Community Environmental Forum Theatre (CEFT), developed through the National Institute of Environmental Health Sciences Center in Environmental Toxicology at the University of Texas Medical Branch/Galveston TX. CEFT integrates the dramaturgy of Augusto Boal's Theatre of the Oppressed and the democratizing dialogic process of Paulo Freire into the design and implementation of environmental health research, community health care and education. CEFT projects throughout the Texas petrochemical belt have used this form of interactive workshop and energized public performance to increase knowledge of toxicological concepts, develop risk awareness, extend and strengthen coalitions, create action agendas and promote community advocacy skills. Boal image-making techniques help to deconstruct concepts such as exposure pathways, dose response, differential susceptibilities, multiple stressors/cumulative risk and the healthy worker effect. Image-based ethnographies provide insight into risk perceptions, risk communication outcomes and overarching community dynamics impacting environmental justice. CEFT project efficacy is evaluated via a multi-frame process focused on goals specific to the roles of the scientific/environmental health outreach specialist, the community development artist/practitioner and the advocate for environmental health and justice issues. JF - Local Environment AU - Sullivan, J AU - Lloyd, R S AD - SCEHM/NIEHS Center, 301 University Boulevard, UTMB at Galveston, Galveston, TX 77555-1071, USA, josulliv@utmb.edu Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 627 EP - 646 VL - 11 IS - 6 SN - 1354-9839, 1354-9839 KW - Health & Safety Science Abstracts; Sustainability Science Abstracts KW - Environmental degradation KW - USA, Texas, Galveston KW - Socioeconomics KW - Environmental health KW - Petrochemicals KW - community development KW - community involvement KW - attitudes KW - ethnography KW - Environmental equity KW - Education KW - Communications KW - Health care KW - Perception KW - USA, Texas KW - Toxicology KW - Occupational exposure KW - M3 1010:Issues in Sustainable Development KW - H 12000:Epidemiology and Public Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19502755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Local+Environment&rft.atitle=The+Forum+Theatre+of+Augusto+Boal%3A+A+Dramatic+Model+for+Dialogue+and+Community-Based+Environmental+Science&rft.au=Sullivan%2C+J%3BLloyd%2C+R+S&rft.aulast=Sullivan&rft.aufirst=J&rft.date=2006-12-01&rft.volume=11&rft.issue=6&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Local+Environment&rft.issn=13549839&rft_id=info:doi/10.1080%2F13549830600853684 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Environmental degradation; Petrochemicals; Environmental health; Socioeconomics; community development; community involvement; attitudes; ethnography; Education; Environmental equity; Communications; Health care; Perception; Occupational exposure; Toxicology; USA, Texas, Galveston; USA, Texas DO - http://dx.doi.org/10.1080/13549830600853684 ER - TY - JOUR T1 - Comparative Metabolism and Disposition of Trichloroethylene in Cyp2e1-/-and Wild-Type Mice AN - 19501711; 7192536 AB - Trichloroethylene (TCE)1 is an important environmental contaminant, a well established rodent carcinogen, and a "probable human carcinogen". Metabolism of TCE occurs primarily via cytochrome P450 (P450)-dependent oxidation. In vitro studies suggested that CYP2E1 is the principal high-affinity enzyme responsible for TCE metabolism. The objective of the present work is to more directly assess the role of CYP2E1 in the metabolism and disposition of 1,2- super(14)C-TCE administered at 250 or 1000 mg/kg (gavage) using Cyp2e1-/-[knockout (KO)] versus wild-type (WT) mice. After dosing, animals were individually placed in glass metabolism cages that allowed the collection of expired air, urine, and feces. Exhalation of TCE-derived super(14)CO sub(2) increased in a dose-dependent manner in mice of both genotypes and was significantly higher in WT versus KO mice. A significantly greater percentage of the dose was exhaled in KO versus WT mice as organic volatiles (mainly as TCE). Urinary excretion was the major route of TCE metabolism in WT mice, and the percentage of dose eliminated in urine was significantly higher at the 250 versus 1000 mg/kg dose. Furthermore, urinary excretion and CO sub(2) exhalation significantly decreased in KO versus WT mice. Pretreatment with 1-aminobenzotriazole clearly inhibited TCE metabolism as evident from increased exhalation of parent TCE, and decreased urinary excretion and CO sub(2) exhalation in mice of both genotypes. In conclusion, these data showed that whereas CYP2E1 plays an important role in TCE metabolism and disposition, other P450s also play a significant role and may explain earlier results showing that TCE causes lung damage in KO and WT mice. JF - Drug Metabolism and Disposition AU - Kim, Dojung AU - Ghanayem, Burhan I AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 2020 EP - 2027 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 34 IS - 12 SN - 0090-9556, 0090-9556 KW - Toxicology Abstracts KW - Enzymes KW - Disposition KW - Genotypes KW - Carcinogens KW - Lung KW - Volatiles KW - Urine KW - Oxidation KW - Excretion KW - Cytochrome P450 KW - Trichloroethylene KW - Feces KW - Contaminants KW - Carbon dioxide KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19501711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Comparative+Metabolism+and+Disposition+of+Trichloroethylene+in+Cyp2e1-%2F-and+Wild-Type+Mice&rft.au=Kim%2C+Dojung%3BGhanayem%2C+Burhan+I&rft.aulast=Kim&rft.aufirst=Dojung&rft.date=2006-12-01&rft.volume=34&rft.issue=12&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Drug+Metabolism+and+Disposition&rft.issn=00909556&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzymes; Disposition; Carcinogens; Genotypes; Urine; Volatiles; Lung; Oxidation; Excretion; Trichloroethylene; Cytochrome P450; Carbon dioxide; Contaminants; Feces ER - TY - JOUR T1 - Antifungal interactions within the triple combination of amphotericin B, caspofungin and voriconazole against Aspergillus species AN - 19500778; 7192841 AB - OBJECTIVES: The in vitro effects of caspofungin combined with voriconazole and amphotericin B were tested in triplicate experiments against nine clinical isolates of Aspergillus fumigatus, Aspergillus flavus and Aspergillus terreus. METHODS: The isolates were tested against a range of concentrations of voriconazole (0.015-1.0 mg/L), caspofungin (0.125-256 mg/L) and five concentrations of amphotericin B (0.1-0.5 mg/L) with a microdilution chequerboard method based on the CLSI M38-A reference method and the results were analysed with the fractional inhibitory concentration (FIC) index. The effect of individual drugs on the FIC index of each of the double combinations was also evaluated. RESULTS: The triple combination of voriconazole, caspofungin and amphotericin B against all Aspergillus spp. was synergistic (FIC index 0.49-0.57) at low median concentrations of amphotericin B (0.10-0.22 mg/L) and voriconazole (0.07-0.15 mg/L) over a wide range of caspofungin concentrations (4.32-17.28 mg/L). Antagonistic interactions (FIC index 1.65-2.15) were found at higher median concentrations of amphotericin B (0.3-0.5 mg/L) and voriconazole (0.23-0.68 mg/L) over a similarly wide range of caspofungin concentrations (1.47-32 mg/L). CONCLUSIONS: These concentration-dependent interactions may have important clinical implications, which require further evaluation in animal models of invasive aspergillosis. JF - Journal of Antimicrobial Chemotherapy AU - O'Shaughnessy, Elizabeth M AU - Meletiadis, Joseph AU - Stergiopoulou, Theodouli AU - Demchok, Joanne P AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, Clinical Cancer Research, National Cancer Institute National Institutes of Health, Bethesda, MD, USA Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1168 EP - 1176 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 58 IS - 6 SN - 0305-7453, 0305-7453 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Clinical isolates KW - Amphotericin B KW - Aspergillus flavus KW - Aspergillus fumigatus KW - Caspofungin KW - Voriconazole KW - Animal models KW - Aspergillosis KW - Aspergillus terreus KW - Drugs KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Antimicrobial+Chemotherapy&rft.atitle=Antifungal+interactions+within+the+triple+combination+of+amphotericin+B%2C+caspofungin+and+voriconazole+against+Aspergillus+species&rft.au=O%27Shaughnessy%2C+Elizabeth+M%3BMeletiadis%2C+Joseph%3BStergiopoulou%2C+Theodouli%3BDemchok%2C+Joanne+P%3BWalsh%2C+Thomas+J&rft.aulast=O%27Shaughnessy&rft.aufirst=Elizabeth&rft.date=2006-12-01&rft.volume=58&rft.issue=6&rft.spage=1168&rft.isbn=&rft.btitle=&rft.title=Journal+of+Antimicrobial+Chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Amphotericin B; Voriconazole; Caspofungin; Animal models; Aspergillosis; Drugs; Aspergillus flavus; Aspergillus fumigatus; Aspergillus terreus ER - TY - JOUR T1 - Evaluation of pan-fungal PCR assay and Aspergillus antigen detection in the diagnosis of invasive fungal infections in high risk paediatric cancer patients AN - 19500233; 7195077 AB - Profound and prolonged neutropenia following chemotherapy is a major risk factor for systemic fungal infection. As the early diagnosis of invasive fungal infection (IFI) is difficult, these infections are still associated with high morbidity and mortality. Recently, Pan-fungal polymerase chain reaction (PCR) has been a promising aid in rapid, early diagnosis of IFI. During the past few years, increasing numbers of suspected IFIs were encountered at our institution in patients with prolonged neutropenia after intensified immunosuppressive chemotherapy. The aim of this study was to investigate the diagnostic utility of both the aspergillus galactomannan (GM) antigen and the pan-fungal PCR assay in the diagnosis of IFI in high risk febrile neutropenic paediatric cancer patients. During one year period, 91 febrile neutropenic (FN) paediatric cases at high risk for developing IFI while receiving chemotherapy were investigated at National Cancer Institute, Egypt. These patients were subjected to clinical evaluation, chest CT scan, conventional blood cultures for bacterial and fungal pathogens, aspergillus GM antigen detection and PCR assay utilizing pan-fungal primers. Of the 91 FN episodes, 15 were proven IFI; whereas 27 cases were either probable (n=13) or possible IFI (n=14), and 49 were unlikely to be IFI episodes. Based on positive results for proven/probable IFI and compared to culture results, Pan-fungal PCR showed sensitivity, specificity, positive and negative predictive values of 75%, 92%, 84% and 87%; respectively. Aspergillus antigen test showed a sensitivity of 79%, specificity of 61%, positive and negative predictive values of 54% and 83%; respectively. A negative PCR in the proven and probable cases was closely related to previous antifungal therapy for a prior history of IFI. In patients at high risk for IFI, neither the sensitivity, nor specificity of the GM test was sufficient. The results of PCR assay was reasonably specific but not very sensitive and had a chance of missing the diagnosis of IFI. The PCR assay seems a promising test for objectively defining IFI, but is not recommended as the only tool for diagnosing IFI. Combining microscopy, culture, and PCR may improve the diagnostic outcome. JF - Medical Mycology AU - El-Mahallawy, HA AU - Shaker, H H AU - Helmy, HA AU - Mostafa, T AU - Abo-Sedah, A R AD - Departments of Clinical Pathology, National Cancer Institute, Faculty of Medicine, Cairo University, Department of Microbiology, Faculty of Science El-Azhar University, Cairo, Egypt Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 733 EP - 739 VL - 44 IS - 8 SN - 1369-3786, 1369-3786 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Blood culture KW - Risk assessment KW - Mortality KW - Invasiveness KW - Pediatrics KW - Chemotherapy KW - Aspergillus KW - Pathogens KW - Infection KW - Chest KW - Morbidity KW - Cancer KW - Neutropenia KW - Risk factors KW - Microscopy KW - Computed tomography KW - Polymerase chain reaction KW - Primers KW - K 03300:Methods KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+Mycology&rft.atitle=Evaluation+of+pan-fungal+PCR+assay+and+Aspergillus+antigen+detection+in+the+diagnosis+of+invasive+fungal+infections+in+high+risk+paediatric+cancer+patients&rft.au=El-Mahallawy%2C+HA%3BShaker%2C+H+H%3BHelmy%2C+HA%3BMostafa%2C+T%3BAbo-Sedah%2C+A+R&rft.aulast=El-Mahallawy&rft.aufirst=HA&rft.date=2006-12-01&rft.volume=44&rft.issue=8&rft.spage=733&rft.isbn=&rft.btitle=&rft.title=Medical+Mycology&rft.issn=13693786&rft_id=info:doi/10.1080%2F13693780600939955 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Risk assessment; Blood culture; Mortality; Invasiveness; Pediatrics; Chemotherapy; Pathogens; Chest; Infection; Cancer; Morbidity; Neutropenia; Risk factors; Computed tomography; Microscopy; Polymerase chain reaction; Primers; Aspergillus DO - http://dx.doi.org/10.1080/13693780600939955 ER - TY - JOUR T1 - Preclinical Model To Test Human Papillomavirus Virus (HPV) Capsid Vaccines In Vivo Using Infectious HPV/Cottontail Rabbit Papillomavirus Chimeric Papillomavirus Particles AN - 19498308; 7193641 AB - A human papillomavirus (HPV) vaccine consisting of virus-like particles (VLPs) was recently approved for human use. It is generally assumed that VLP vaccines protect by inducing type-specific neutralizing antibodies. Preclinical animal models cannot be used to test for protection against HPV infections due to species restriction. We developed a model using chimeric HPV capsid/cottontail rabbit papillomavirus (CRPV) genome particles to permit the direct testing of HPV VLP vaccines in rabbits. Animals vaccinated with CRPV, HPV type 16 (HPV-16), or HPV-11 VLPs were challenged with both homologous (CRPV capsid) and chimeric (HPV-16 capsid) particles. Strong type-specific protection was observed, demonstrating the potential application of this approach. JF - Journal of Virology AU - Mejia, Andres F AU - Culp, Timothy D AU - Cladel, Nancy M AU - Balogh, Karla K AU - Budgeon, Lynn R AU - Buck, Christopher B AU - Christensen, Neil D AD - Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania. Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 12393 EP - 12397 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 24 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Genomes KW - Virus-like particles KW - Animal models KW - Cottontail rabbit papillomavirus KW - Infection KW - Capsids KW - Antibodies KW - Vaccines KW - Human papillomavirus KW - V 22350:Immunology KW - F 06905:Vaccines KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19498308?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Preclinical+Model+To+Test+Human+Papillomavirus+Virus+%28HPV%29+Capsid+Vaccines+In+Vivo+Using+Infectious+HPV%2FCottontail+Rabbit+Papillomavirus+Chimeric+Papillomavirus+Particles&rft.au=Mejia%2C+Andres+F%3BCulp%2C+Timothy+D%3BCladel%2C+Nancy+M%3BBalogh%2C+Karla+K%3BBudgeon%2C+Lynn+R%3BBuck%2C+Christopher+B%3BChristensen%2C+Neil+D&rft.aulast=Mejia&rft.aufirst=Andres&rft.date=2006-12-01&rft.volume=80&rft.issue=24&rft.spage=12393&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human papillomavirus; Cottontail rabbit papillomavirus; Vaccines; Capsids; Animal models; Genomes; Infection; Antibodies; Virus-like particles ER - TY - JOUR T1 - Evidence for Recombination in Mycobacterium tuberculosis AN - 19497487; 7192952 AB - Due to its mostly isolated living environment, Mycobacterium tuberculosis is generally believed to be highly clonal, and thus recombination between different strains must be rare and is not critical for the survival of the species. To investigate the roles recombination could have possibly played in the evolution of M. tuberculosis, an analysis was conducted on previously determined genotypes of 36 synonymous single nucleotide polymorphisms (SNPs) in 3,320 M. tuberculosis isolates. The results confirmed the predominant clonal structure of the M. tuberculosis population. However, recombination between different strains was also suggested. To further resolve the issue, 175 intergenic SNPs and 234 synonymous SNPs were genotyped in 37 selected representative strains. A clear mosaic polymorphic pattern ahead of the MT0105 locus encoding a PPE (Pro-Pro-Glu) protein was obtained, which is most likely a result of recombination hot spot. Given that PPE proteins are thought to be critical in host-pathogen interactions, we hypothesize that recombination has been influential in the history of M. tuberculosis and possibly a major contributor to the diversity observed ahead of the MT0105 locus. JF - Journal of Bacteriology AU - Liu, Xiaoming AU - Gutacker, Michaela M AU - Musser, James M AU - Fu, Yun-Xin AD - Human Genetics Center, University of Texas at Houston, Houston, Texas 77225. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, Montana 59840. Center for Human Bacterial Pathogenesis Research, Department of Pathology, Baylor College of Medicine, Houston, Texas 77030 Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 8169 EP - 8177 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 23 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Recombination KW - Single-nucleotide polymorphism KW - Hot spots KW - Host-pathogen interactions KW - Mosaics KW - Survival KW - Tuberculosis KW - Evolution KW - Mycobacterium tuberculosis KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19497487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Evidence+for+Recombination+in+Mycobacterium+tuberculosis&rft.au=Liu%2C+Xiaoming%3BGutacker%2C+Michaela+M%3BMusser%2C+James+M%3BFu%2C+Yun-Xin&rft.aulast=Liu&rft.aufirst=Xiaoming&rft.date=2006-12-01&rft.volume=188&rft.issue=23&rft.spage=8169&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Recombination; Hot spots; Single-nucleotide polymorphism; Host-pathogen interactions; Mosaics; Survival; Tuberculosis; Evolution; Mycobacterium tuberculosis ER - TY - JOUR T1 - Adding sequence context to a Markov background model improves the identification of regulatory elements AN - 19496328; 7191955 AB - MOTIVATION: Many computational methods for identifying regulatory elements use a likelihood ratio between motif and background models. Often, the methods use a background model of independent bases. At least two different Markov background models have been proposed with the aim of increasing the accuracy of predicting regulatory elements. Both Markov background models suffer theoretical drawbacks, so this article develops a third, context-dependent Markov background model from fundamental statistical principles. RESULTS: Datasets containing known regulatory elements in eukaryotes provided a basis for comparing the predictive accuracies of the different background models. Non-parametric statistical tests indicated that Markov models of order 3 constituted a statistically significant improvement over the background model of independent bases. Our model performed slightly better than the previous Markov background models. We also found that for discriminating between the predictive accuracies of competing background models, the correlation coefficient is a more sensitive measure than the performance coefficient. AVAILABILITY: Our C++ program is available at ftp://ftp.ncbi.nih.gov/pub/spouge/papers/archive/AGLAM/2006-07-19 CONTACT: spougecbi.nlm.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Kim, Nak-Kyeong AU - Tharakaraman, Kannan AU - Spouge, John L AD - National Center for Biotechnology Information, National Library of Medicine National Institutes of Health, Bethesda, MD 20894, USA Y1 - 2006/12/01/ PY - 2006 DA - 2006 Dec 01 SP - 2870 EP - 2875 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 23 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Computer programs KW - Mathematical models KW - Regulatory sequences KW - Statistical analysis KW - Bioinformatics KW - Computer applications KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19496328?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=Adding+sequence+context+to+a+Markov+background+model+improves+the+identification+of+regulatory+elements&rft.au=Kim%2C+Nak-Kyeong%3BTharakaraman%2C+Kannan%3BSpouge%2C+John+L&rft.aulast=Kim&rft.aufirst=Nak-Kyeong&rft.date=2006-12-01&rft.volume=22&rft.issue=23&rft.spage=2870&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Models; Statistical analysis; Regulatory sequences; Bioinformatics; Mathematical models; Computer programs; Computer applications ER - TY - JOUR T1 - Polyps: Linear and Volumetric Measurement at CT Colonography AN - 19494797; 7194169 AB - PURPOSE: To retrospectively determine which of several computed tomographic (CT) colonography-based polyp measurements is most compatible with the linear measurement at optical colonoscopy and which is best for assessing change in polyp size. MATERIALS AND METHODS: This HIPAA-compliant study had institutional review board approval; informed consent was obtained. Prone and supine CT colonography with same-day optical colonoscopy was performed in 216 patients (147 men and 69 women; age range, 46-79 years; mean age, 59.2 years) with 338 polyps detected at CT colonography. Polyp size was measured with three linear measurements and two volume measurements. One linear measurement and one volume measurement were performed by using automated segmentation; remaining measurements were performed manually. Compatibility with linear size at optical colonoscopy and measurement reproducibility were assessed three ways: variation from size measurement at optical colonoscopy, change between prone and supine scans, and variability between observers. Confidence analysis assessed the ability of each measurement to identify polyps with an optical colonoscopy measurement of 1 cm or greater. RESULTS: Two hundred fifty-one segmentable polyps were present on both supine and prone scans. Linear polyp diameter manually measured on a three-dimensional endoluminally viewed surface (L sub(M3D)) indicated with 95% confidence that a polyp measured as 0.8 cm or smaller was less than 1.0 cm at optical colonoscopy. Prone and supine polyp size difference was smallest for L sub(M3D) and the linear diameter computed from manual and automated volume measurements, with interquartile ranges smaller than or equal to 0.3, 0.2, and 0.5 cm, respectively. Interobserver and intraobserver variability was smallest for linear polyp diameter measurements on a two-dimensional display, with a mean percentage difference of 2.8% (95% Bland-Altman limits of agreement: -17.8%, 23.4%) and 5.0% (95% Bland-Altman limits of agreement: -28.3%, 38.3%), respectively. CONCLUSION: L sub(M3D) best approximated polyp size measurements at optical colonoscopy. Linear diameter calculated from automated volume measurements showed the smallest variation between supine and prone scans while avoiding observer variability and may be best for assessing polyp size changes with serial examinations. [copy ] RSNA, 2006 JF - Radiology AU - Yeshwant, Srinath C AU - Summers, Ronald M AU - Yao, Jianhua AU - Brickman, Daniel S AU - Choi, JRichard AU - Pickhardt, Perry J AD - Diagnostic Radiology Department, Clinical Center, National Institutes of Health, Bldg 10, Room 1C351, 10 Center Dr, MSC 1182, Bethesda, MD 20892-1182 (S.C.Y., R.M.S., J.Y., D.S.B.) Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 802 EP - 811 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 241 IS - 3 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Segmentation KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19494797?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=Polyps%3A+Linear+and+Volumetric+Measurement+at+CT+Colonography&rft.au=Yeshwant%2C+Srinath+C%3BSummers%2C+Ronald+M%3BYao%2C+Jianhua%3BBrickman%2C+Daniel+S%3BChoi%2C+JRichard%3BPickhardt%2C+Perry+J&rft.aulast=Yeshwant&rft.aufirst=Srinath&rft.date=2006-12-01&rft.volume=241&rft.issue=3&rft.spage=802&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Polyps; Computed tomography; Segmentation ER - TY - JOUR T1 - Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp. AN - 19491976; 7192762 AB - Relapsing fever Borrelia spp. undergo antigenic variation, achieve high levels in blood, and require rapid production of immunoglobulin M (IgM) for clearance. MyD88-deficient mice display defective clearance of many pathogens; however, the IgM response to persistent infection is essentially normal. Therefore, MyD88 super(-/-) mice provided a unique opportunity to study the effect of nonantibody, innate host defenses to relapsing fever BORRELIA: Infected MyD88 super(-/-) mice harbored extremely high levels of B. hermsii in the blood compared to wild-type littermates. In the comparison of MyD88 super(-/-) mice and B- and T-cell-deficient scid mice, two features stood out: (i) bacterial numbers in blood were at least 10-fold greater in MyD88 super(-/-) mice than scid mice, even though the production of IgM still occurred in MyD88 super(-/-) mice; and (ii) many of the MyD88 super(-/-) mice were able to exert partial clearance, although with delayed kinetics relative to wild-type mice, a feature not seen in scid mice. Further analysis revealed a delay in the IgM response to lipoproteins expressed by the original inoculum; however, by 6 days of infection antibodies were produced in MyD88 super(-/-) mice that could clear spirochetemia in scid mice. While these results indicated that the production of IgM was delayed in MyD88 super(-/-) mice, they also point to a second, antibody-independent role for MyD88 signaling in host defense to relapsing fever BORRELIA: This second defect was apparent only when antibody levels were limiting. JF - Infection and Immunity AU - Bolz, Devin D AU - Sundsbak, Rhianna S AU - Ma, Ying AU - Akira, Shizuo AU - Weis, John H AU - Schwan, Tom G AU - Weis, Janis J AD - Department of Pathology, University of Utah, Salt Lake City, Utah 84112. Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan. Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Disease, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 6750 EP - 6760 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 12 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - MyD88 protein KW - Relapsing fever KW - Pathogens KW - Persistent infection KW - Blood KW - Kinetics KW - Lipoproteins KW - Inoculum KW - Lymphocytes T KW - Borrelia KW - Immunoglobulin M KW - Signal transduction KW - J 02350:Immunology KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19491976?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Dual+Role+of+MyD88+in+Rapid+Clearance+of+Relapsing+Fever+Borrelia+spp.&rft.au=Bolz%2C+Devin+D%3BSundsbak%2C+Rhianna+S%3BMa%2C+Ying%3BAkira%2C+Shizuo%3BWeis%2C+John+H%3BSchwan%2C+Tom+G%3BWeis%2C+Janis+J&rft.aulast=Bolz&rft.aufirst=Devin&rft.date=2006-12-01&rft.volume=74&rft.issue=12&rft.spage=6750&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Blood; MyD88 protein; Kinetics; Relapsing fever; Lipoproteins; Lymphocytes T; Inoculum; Pathogens; Persistent infection; Immunoglobulin M; Signal transduction; Borrelia ER - TY - JOUR T1 - An adaptive filter for suppression of cardiac and respiratory noise in MRI time series data AN - 19474912; 7161260 AB - The quality of MRI time series data, which allows the study of dynamic processes, is often affected by confounding sources of signal fluctuation, including the cardiac and respiratory cycle. An adaptive filter is described, reducing these signal fluctuations as long as they are repetitive and their timing is known. The filter, applied in image domain, does not require temporal oversampling of the artifact-related fluctuations. Performance is demonstrated for suppression of cardiac and respiratory artifacts in 10-minute brain scans on 6 normal volunteers. Experimental parameters resemble a typical fMRI experiment (17 slices; 1700 ms TR). A second dataset was acquired at a rate well above the Nyquist frequency for both cardiac and respiratory cycle (single slice; 100 ms TR), allowing identification of artifacts specific to the cardiac and respiratory cycles, aiding assessment of filtering performance. Results show significant reduction in temporal standard deviation (SD sub(t)) in all subjects. For all 6 datasets with 1700 ms TR combined, the filtering method resulted in an average reduction in SD sub(t) of 9.2% in 2046 voxels substantially affected by respiratory artifacts, and 12.5% for the 864 voxels containing substantial cardiac artifacts. The maximal SD sub(t) reduction achieved was 52.7% for respiratory and 55.3% for cardiac filtering. Performance was found to be at least equivalent to the previously published RETROICOR method. Furthermore, the interaction between the filter and fMRI activity detection was investigated using Monte Carlo simulations, demonstrating that filtering algorithms introduce a systematic error in the detected BOLD-related signal change if applied sequentially. It is demonstrated that this can be overcome by combining physiological artifact filtering and detection of BOLD-related signal changes simultaneously. Visual fMRI data from 6 volunteers were analyzed with and without the filter proposed here. Inclusion of the cardio-respiratory regressors in the design matrix yielded a 4.6% t-score increase and 4.0% increase in the number of significantly activated voxels. JF - NeuroImage AU - Deckers, Roel HR AU - Van Gelderen, Peter AU - Ries, Mario AU - Barret, Olivier AU - Duyn, Jeff H AU - Ikonomidou, Vasiliki N AU - Fukunaga, Masaki AU - Glover, Gary H AU - De Zwart, Jacco A AD - Advanced MRI section, LFMI, NINDS, National Institutes of Health, Bldg. 10, Rm. B1D-728, MSC 1065, 9000 Rockville Pike, Bethesda, MD 20892-1065, USA, Jacco.deZwart@nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 1072 EP - 1081 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 33 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Monte Carlo simulation KW - Heart KW - Functional magnetic resonance imaging KW - Brain KW - Algorithms KW - Filters KW - Standard deviation KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19474912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=An+adaptive+filter+for+suppression+of+cardiac+and+respiratory+noise+in+MRI+time+series+data&rft.au=Deckers%2C+Roel+HR%3BVan+Gelderen%2C+Peter%3BRies%2C+Mario%3BBarret%2C+Olivier%3BDuyn%2C+Jeff+H%3BIkonomidou%2C+Vasiliki+N%3BFukunaga%2C+Masaki%3BGlover%2C+Gary+H%3BDe+Zwart%2C+Jacco+A&rft.aulast=Deckers&rft.aufirst=Roel&rft.date=2006-12-01&rft.volume=33&rft.issue=4&rft.spage=1072&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.08.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Filters; Functional magnetic resonance imaging; Heart; Algorithms; Monte Carlo simulation; Standard deviation; Brain DO - http://dx.doi.org/10.1016/j.neuroimage.2006.08.006 ER - TY - JOUR T1 - Segmentation of brain tumors in 4D MR images using the hidden Markov model AN - 19473952; 7140195 AB - Tumor size is an objective measure that is used to evaluate the effectiveness of anticancer agents. Responses to therapy are categorized as complete response, partial response, stable disease and progressive disease. Implicit in this scheme is the change in the tumor over time; however, most tumor segmentation algorithms do not use temporal information. Here we introduce an automated method using probabilistic reasoning over both space and time to segment brain tumors from 4D spatio-temporal MRI data. The 3D expectation- maximization method is extended using the hidden Markov model to infer tumor classification based on previous and subsequent segmentation results. Spatial coherence via a Markov Random Field was included in the 3D spatial model. Simulated images as well as patient images from three independent sources were used to validate this method. The sensitivity and specificity of tumor segmentation using this spatio-temporal model is improved over commonly used spatial or temporal models alone. JF - Computer Methods and Programs in Biomedicine AU - Solomon, Jeffrey AU - Butman, John A AU - Sood, Arun AD - Medical Numerics Inc., Sterling, VA, USA, jsolomon@cc.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 76 EP - 85 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo@elsevier.com], [URL:http://www.elsevier.nl] VL - 84 IS - 2-3 SN - 0169-2607, 0169-2607 KW - Biotechnology and Bioengineering Abstracts KW - Brain tumors KW - Classification KW - hidden Markov models KW - Magnetic resonance imaging KW - Algorithms KW - Segmentation KW - Automation KW - Image processing KW - Tumors KW - Computer applications KW - Antitumor agents KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19473952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computer+Methods+and+Programs+in+Biomedicine&rft.atitle=Segmentation+of+brain+tumors+in+4D+MR+images+using+the+hidden+Markov+model&rft.au=Solomon%2C+Jeffrey%3BButman%2C+John+A%3BSood%2C+Arun&rft.aulast=Solomon&rft.aufirst=Jeffrey&rft.date=2006-12-01&rft.volume=84&rft.issue=2-3&rft.spage=76&rft.isbn=&rft.btitle=&rft.title=Computer+Methods+and+Programs+in+Biomedicine&rft.issn=01692607&rft_id=info:doi/10.1016%2Fj.cmpb.2006.09.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Segmentation; Image processing; hidden Markov models; Brain tumors; Classification; Antitumor agents; Algorithms; Computer applications; Magnetic resonance imaging; Automation DO - http://dx.doi.org/10.1016/j.cmpb.2006.09.007 ER - TY - JOUR T1 - Docking studies of agonists and antagonists suggest an activation pathway of the A sub(3) adenosine receptor AN - 19464678; 7139467 AB - Structural determinants of ligand efficacy in the human A sub(3) adenosine receptor (AR) were studied using pharmacophore and docking analyses of various categories of A sub(3) selective ligands: inverse agonist, neutral antagonist (nonnucleoside and nucleoside), and agonist (partial and full). The homology modeling of GPCRs was adapted to provide two templates: the rhodopsin-based resting state for antagonist binding and a putative Meta I state, conformationally altered at a key residue (W6.48), for agonist binding. The preferential binding domains and/or local conformational changes associated with docking of three high affinity A sub(3)AR ligands were compared: inverse agonist PSB-11 1 ((R)-8-ethyl-4-methyl-2-phenyl-imidazo[2,1-i]purin-5-one); neutral antagonist MRE-3008F20 7 (5-[[(4-methoxyphenyl)amino]carbonyl]amino-8-methyl-2- (2-furyl)pyra-zolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine), and full agonist Cl- IB-MECA 21 (2-chloro-N super(6)-(3-iodobenzyl)-5-N- methylcarboxamidoadenosine) to define a distinct recognition mode for each. Ribose-containing agonists were more hydrophilic than nonnucleoside antagonists, and H-bonding ability at the ribose 3- and 5-positions was required for agonism. From the receptor perspective, common requirements for activation included the destabilization of H-bond networks at W6.48 and H7.43, the specific interactions of the ribose moiety in its putative hydrophilic pocket at T3.36, S7.42, and H7.43, the stabilization of the complex by inward movement of F5.43, and the characteristic rotation of W6.48. By analogy, outward rotation of the W6.48 side-chain upon activation of an internally-crosslinking mutant M sub(3) muscarinic receptor was indicated by constrained molecular dynamics (MD). Our results are consistent with an anti-clockwise rotation (from the extracellular view) of transmembrane domains 3, 5, 6, and 7, as proposed for other Family A GPCRs. Thus, the putative conformational changes associated with A sub(3)AR activation indicate a shared mechanism of GPCR activation similar to rhodopsin. JF - Journal of Molecular Graphics and Modelling AU - Kim, Soo-Kyung AU - Gao, Zhan-Guo AU - Jeong, Lak Shin AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA, kajacobs@helix.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 562 EP - 577 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 4 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - Purines KW - G-protein-coupled receptor KW - Homology modeling KW - 7TM receptor KW - Binding site KW - Nucleoside KW - Inverse agonists KW - Adenosine receptors KW - double prime G protein-coupled receptors KW - Ribose KW - Acetylcholine receptors (muscarinic) KW - Chloride KW - Transmembrane domains KW - Antagonists KW - Rhodopsin KW - Homology KW - nucleosides KW - pharmacophores KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Docking+studies+of+agonists+and+antagonists+suggest+an+activation+pathway+of+the+A+sub%283%29+adenosine+receptor&rft.au=Kim%2C+Soo-Kyung%3BGao%2C+Zhan-Guo%3BJeong%2C+Lak+Shin%3BJacobson%2C+Kenneth+A&rft.aulast=Kim&rft.aufirst=Soo-Kyung&rft.date=2006-12-01&rft.volume=25&rft.issue=4&rft.spage=562&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Inverse agonists; Homology; Rhodopsin; double prime G protein-coupled receptors; Adenosine receptors; nucleosides; Acetylcholine receptors (muscarinic); Ribose; Chloride; Transmembrane domains; pharmacophores; Antagonists DO - http://dx.doi.org/10.1016/j.jmgm.2006.05.004 ER - TY - JOUR T1 - Computational prediction of homodimerization of the A sub(3) adenosine receptor AN - 19464000; 7139466 AB - Increasing evidence suggests that G protein-coupled receptors form functional dimers or larger oligomeric complexes through homo- or heterodimerization, and that various transmembrane (TM) domains contribute dimerization interfaces. In this study, monomeric receptor structures - either the monomeric crystallographic structure of bovine rhodopsin or an A sub(3) adenosine receptor (AR) homology model - were dimerized by computational methods assuming various TM contact regions, optimized, and compared. The semi-empirical oligomeric structure of mouse rhodopsin studied in a native disc membrane with atomic force microscopy was used to establish the distance between monomers in the initial dimeric models. Among eight variations of symmetrical homodimers of bovine rhodopsin, the favored dimeric assembly closely resembled the semi- empirical model, in which TM domains 4 and 5 were the contact site, thus validating this approach. We used similar methods to generate eight homodimers of the A sub(3)AR and found the favored dimeric interface similarly to be TM4-5. By this method, dimeric variations - TM1-2, TM2-3, TM2-4, TM3-4, TM4-5, TM5-6, TM6-7, and TM7-1 - were constructed with the SYBYL 7.0 program by using a novel "fit-centroids-normal" method. Fitting atoms considered one of eight TM-TM centroids or seven-TM centroids, two centroids of each monomer, and a normal atom passing through the plane containing all centroids. Following molecular dynamics, the most energetically favorable contact modes were identified. In addition to TM4-5, which was favored in both rhodopsin and A sub(3)AR dimeric models, TM1-2 dimers in which helices 8 also contacted each other were judged favorable. The largest contact surface area between the monomers among the various homodimers, determined by van der Waals calculation with the MOLCAD surface program, was for the TM4-5 dimer. This contact surface also showed a high degree of shape complementarity. In addition, the TM4-5 dimers made by this theoretical method were more stable than the semi-empirically determined dimer. JF - Journal of Molecular Graphics and Modelling AU - Kim, Soo-Kyung AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, MD 20892, USA, kajacobs@helix.nih.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 549 EP - 561 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 4 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts KW - GPCRs KW - Purine receptors KW - Rhodopsin KW - Homology modeling KW - Protein-protein docking KW - Monomers KW - Homology KW - Adenosine receptors KW - double prime G protein-coupled receptors KW - Surface area KW - atomic force microscopy KW - Computer applications KW - Complementarity KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Computational+prediction+of+homodimerization+of+the+A+sub%283%29+adenosine+receptor&rft.au=Kim%2C+Soo-Kyung%3BJacobson%2C+Kenneth+A&rft.aulast=Kim&rft.aufirst=Soo-Kyung&rft.date=2006-12-01&rft.volume=25&rft.issue=4&rft.spage=549&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.03.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Monomers; Homology; Rhodopsin; double prime G protein-coupled receptors; Adenosine receptors; Surface area; atomic force microscopy; Computer applications; Complementarity; Models DO - http://dx.doi.org/10.1016/j.jmgm.2006.03.003 ER - TY - JOUR T1 - Graphical exploratory data analysis of RNA secondary structure dynamics predicted by the massively parallel genetic algorithm AN - 19460477; 7139463 AB - Studies indicate that RNA may enter intermediate and multiple conformational states, which may impact gene expression and molecular function. It is known that the biologically functional states of RNA molecules may not correspond to their minimum energy conformations, that kinetic barriers may trap the molecule in a local minimum, that folding often occurs during transcription, and that cases exist in which a molecule will transition between one or more functional conformations. Thus, methods for simulating the folding pathway and dynamic behavior of an RNA molecule are important for the prediction of RNA structure and its associated functions. We have developed several data mining techniques guided by interactive visualization tools associated with our massively parallel genetic algorithm for RNA/DNA secondary structure prediction, MPGAfold, and StructureLab analysis workbench. Most of the methods and tools are also applicable to dynamic programming algorithm (DPA) folding data analysis. When applied to MPGAfold results these methodologies are used to determine the significant intermediate and final structures associated with co-transcriptional and full length RNA folding. Since the genetic algorithm is essentially stochastic, multiple runs are required to develop a consensus understanding of an RNA structure. The interactive visualizations facilitate interpretation of results from sequential or full length individual MPGAfold runs, final results of multiple folding runs, including multiple population sizes, and the results from multiple RNA sequences of one family. This paper describes several of these techniques and shows how they are used to help solve this highly combinatoric problem. JF - Journal of Molecular Graphics and Modelling AU - Shapiro, Bruce A AU - Kasprzak, Wojciech AU - Grunewald, Calvin AU - Aman, Javed AD - Center for Cancer Research Nanobiology Program, National Cancer Institute, Building 469, Room 150, Frederick, MD 21702, United States, bshapiro@ncifcrf.gov Y1 - 2006/12// PY - 2006 DA - Dec 2006 SP - 514 EP - 531 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 4 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - RNA secondary structure KW - HIV-1 structural metastability KW - Folding pathway KW - Visual datamining KW - Massively parallel genetic algorithm (MPGAfold) KW - StructureLab analysis workbench KW - Protein structure KW - Gene expression KW - Data processing KW - DNA structure KW - RNA KW - Protein folding KW - Kinetics KW - Secondary structure KW - Algorithms KW - Transcription KW - Conformation KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19460477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Graphical+exploratory+data+analysis+of+RNA+secondary+structure+dynamics+predicted+by+the+massively+parallel+genetic+algorithm&rft.au=Shapiro%2C+Bruce+A%3BKasprzak%2C+Wojciech%3BGrunewald%2C+Calvin%3BAman%2C+Javed&rft.aulast=Shapiro&rft.aufirst=Bruce&rft.date=2006-12-01&rft.volume=25&rft.issue=4&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Protein structure; DNA structure; Data processing; Protein folding; RNA; Kinetics; Secondary structure; Algorithms; Transcription; Conformation DO - http://dx.doi.org/10.1016/j.jmgm.2006.04.004 ER - TY - JOUR T1 - NSAID activated gene (NAG-1), a modulator of tumorigenesis. AN - 68189994; 17129398 AB - The NSAID activated gene (NAG-1), a member of the TGF-beta superfamily, is involved in tumor progression and development. The over-expression of NAG-1 in cancer cells results in growth arrest and increase in apoptosis, suggesting that NAG-1 has anti-tumorigenic activity. This conclusion is further supported by results of experiments with transgenic mice that ubiquitously express human NAG-1. These transgenic mice are resistant to the development of intestinal tumors following treatment with azoxymethane or by introduction of a mutant APC gene. In contrast, other data suggest a pro-tumorigenic role for NAG-1, for example, high expression of NAG-1 is frequently observed in tumors. NAG-1 may be like other members of the TGF-beta superfamily, acting as a tumor suppressor in the early stages, but acting pro-tumorigenic at the later stages of tumor progression. The expression of NAG-1 can be increased by treatment with drugs and chemicals documented to prevent tumor formation and development. Most notable is the increase in NAG-1 expression by the inhibitors of cyclooxygenases that prevent human colorectal cancer development. The regulation of NAG-1 is complex, but these agents act through either p53 or EGR-1 related pathways. In addition, an increase in NAG-1 is observed in inhibition of the AKT/GSK-3beta pathway, suggesting NAG-1 alters cell survival. Thus, NAG-1 expression is regulated by tumor suppressor pathways and appears to modulate tumor progression. JF - Journal of biochemistry and molecular biology AU - Eling, Thomas E AU - Baek, Seung Joon AU - Shim, Minsub AU - Lee, Chang Ho AD - National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC 27709, USA. eling@niehs.nih.gov Y1 - 2006/11/30/ PY - 2006 DA - 2006 Nov 30 SP - 649 EP - 655 VL - 39 IS - 6 SN - 1225-8687, 1225-8687 KW - Anti-Inflammatory Agents, Non-Steroidal KW - 0 KW - Cytokines KW - GDF15 protein, human KW - Gdf15 protein, mouse KW - Growth Differentiation Factor 15 KW - Transforming Growth Factor beta KW - Index Medicus KW - Prostatic Neoplasms -- metabolism KW - Animals KW - Gene Expression Regulation -- physiology KW - Humans KW - Carcinogenicity Tests KW - Mice KW - Gene Expression Regulation -- drug effects KW - Transforming Growth Factor beta -- chemistry KW - Mice, Transgenic KW - Transforming Growth Factor beta -- metabolism KW - Male KW - Anti-Inflammatory Agents, Non-Steroidal -- pharmacology KW - Cell Transformation, Neoplastic -- metabolism KW - Cytokines -- physiology KW - Genes, Tumor Suppressor -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68189994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biochemistry+and+molecular+biology&rft.atitle=NSAID+activated+gene+%28NAG-1%29%2C+a+modulator+of+tumorigenesis.&rft.au=Eling%2C+Thomas+E%3BBaek%2C+Seung+Joon%3BShim%2C+Minsub%3BLee%2C+Chang+Ho&rft.aulast=Eling&rft.aufirst=Thomas&rft.date=2006-11-30&rft.volume=39&rft.issue=6&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Journal+of+biochemistry+and+molecular+biology&rft.issn=12258687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-11-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genome-wide loss of heterozygosity and copy number alteration in esophageal squamous cell carcinoma using the Affymetrix GeneChip Mapping 10 K array. AN - 68221203; 17134496 AB - Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide. Comprehensive genomic characterization of ESCC will further our understanding of the carcinogenesis process in this disease. Genome-wide detection of chromosomal changes was performed using the Affymetrix GeneChip 10 K single nucleotide polymorphism (SNP) array, including loss of heterozygosity (LOH) and copy number alterations (CNA), for 26 pairs of matched germ-line and micro-dissected tumor DNA samples. LOH regions were identified by two methods--using Affymetrix's genotype call software and using Affymetrix's copy number alteration tool (CNAT) software--and both approaches yielded similar results. Non-random LOH regions were found on 10 chromosomal arms (in decreasing order of frequency: 17p, 9p, 9q, 13q, 17q, 4q, 4p, 3p, 15q, and 5q), including 20 novel LOH regions (10 kb to 4.26 Mb). Fifteen CNA-loss regions (200 kb to 4.3 Mb) and 36 CNA-gain regions (200 kb to 9.3 Mb) were also identified. These studies demonstrate that the Affymetrix 10 K SNP chip is a valid platform to integrate analyses of LOH and CNA. The comprehensive knowledge gained from this analysis will enable improved strategies to prevent, diagnose, and treat ESCC. JF - BMC genomics AU - Hu, Nan AU - Wang, Chaoyu AU - Hu, Ying AU - Yang, Howard H AU - Kong, Li-Hui AU - Lu, Ning AU - Su, Hua AU - Wang, Quan-Hong AU - Goldstein, Alisa M AU - Buetow, Kenneth H AU - Emmert-Buck, Michael R AU - Taylor, Philip R AU - Lee, Maxwell P AD - Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, USA. nh38k@nih.gov Y1 - 2006/11/29/ PY - 2006 DA - 2006 Nov 29 SP - 299 VL - 7 KW - Index Medicus KW - Polymorphism, Single Nucleotide KW - Humans KW - Chromosomes, Human KW - Chromosome Aberrations KW - Aged KW - Middle Aged KW - Chromosome Mapping -- methods KW - Male KW - Female KW - Loss of Heterozygosity KW - Genome, Human KW - Oligonucleotide Array Sequence Analysis -- methods KW - Esophageal Neoplasms -- genetics KW - Carcinoma, Squamous Cell -- genetics KW - Gene Dosage -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68221203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+genomics&rft.atitle=Genome-wide+loss+of+heterozygosity+and+copy+number+alteration+in+esophageal+squamous+cell+carcinoma+using+the+Affymetrix+GeneChip+Mapping+10+K+array.&rft.au=Hu%2C+Nan%3BWang%2C+Chaoyu%3BHu%2C+Ying%3BYang%2C+Howard+H%3BKong%2C+Li-Hui%3BLu%2C+Ning%3BSu%2C+Hua%3BWang%2C+Quan-Hong%3BGoldstein%2C+Alisa+M%3BBuetow%2C+Kenneth+H%3BEmmert-Buck%2C+Michael+R%3BTaylor%2C+Philip+R%3BLee%2C+Maxwell+P&rft.aulast=Hu&rft.aufirst=Nan&rft.date=2006-11-29&rft.volume=7&rft.issue=&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=BMC+genomics&rft.issn=1471-2164&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-01 N1 - Date created - 2006-12-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Hum Genet. 2004 May;74(5):886-97 [15060841] Genome Res. 2005 Aug;15(8):1168-76 [16077016] Genes Chromosomes Cancer. 2005 Nov;44(3):271-8 [16015646] Am J Hum Genet. 2005 Sep;77(3):420-9 [16080117] Clin Cancer Res. 1999 Nov;5(11):3476-82 [10589761] Genes Chromosomes Cancer. 2000 Mar;27(3):217-28 [10679910] Carcinogenesis. 2000 Nov;21(11):2019-26 [11062163] Clin Cancer Res. 2001 Apr;7(4):883-91 [11309337] Cancer Res. 2001 May 15;61(10):4098-104 [11358832] Cancer Res. 2002 Aug 1;62(15):4191-3 [12154016] Nat Genet. 2003 Mar;33(3):382-7 [12590262] Cancer Detect Prev. 2003;27(2):132-8 [12670525] Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Feb;23(1):10-4 [12905809] Nat Biotechnol. 2003 Oct;21(10):1233-7 [12960966] Bioinformatics. 2003 Dec 12;19(18):2397-403 [14668223] Oncogene. 2004 Apr 8;23(15):2716-26 [15048096] Cancer Res. 2004 May 1;64(9):3060-71 [15126342] Nucleic Acids Res. 2004;32(9):e69 [15148342] Natl Cancer Inst Monogr. 1982;62:113-20 [7167171] Science. 1996 Nov 8;274(5289):998-1001 [8875945] Hum Genet. 2004 Sep;115(4):327-30 [15290239] Hum Genomics. 2004 May;1(4):287-99 [15588488] Cancer Res. 2005 Jan 1;65(1):34-45 [15665277] Genomics. 2005 Mar;85(3):392-400 [15718106] Cancer Res. 2005 Apr 1;65(7):2542-6 [15805246] Cancer Res. 2005 Apr 15;65(8):3053-8 [15833833] Cancer Res. 2005 Oct 1;65(19):8597-603 [16204023] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - HCV-Related Immunocytoma and Tumor-Associated Autoantibodies T2 - 5th International Congress on Autoimmunity AN - 39336936; 4498069 JF - 5th International Congress on Autoimmunity AU - De Re, V. AU - Simula, M P AU - Caggiari, L AU - Marzotto, A AU - Gloghini, A Y1 - 2006/11/29/ PY - 2006 DA - 2006 Nov 29 KW - Autoantibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39336936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+International+Congress+on+Autoimmunity&rft.atitle=HCV-Related+Immunocytoma+and+Tumor-Associated+Autoantibodies&rft.au=De+Re%2C+V.%3BSimula%2C+M+P%3BCaggiari%2C+L%3BMarzotto%2C+A%3BGloghini%2C+A&rft.aulast=De+Re&rft.aufirst=V.&rft.date=2006-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+International+Congress+on+Autoimmunity&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/autoimmunity/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain-Specific Autoantibodies in the Plasma of Patients with Autism Spectrum Disorder T2 - 5th International Congress on Autoimmunity AN - 39325607; 4498237 JF - 5th International Congress on Autoimmunity AU - Van De Water, J.A. AU - Cabanlit, M AU - Wills, S AU - Ashwood, P Y1 - 2006/11/29/ PY - 2006 DA - 2006 Nov 29 KW - Autism KW - Autoantibodies KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39325607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+International+Congress+on+Autoimmunity&rft.atitle=Brain-Specific+Autoantibodies+in+the+Plasma+of+Patients+with+Autism+Spectrum+Disorder&rft.au=Van+De+Water%2C+J.A.%3BCabanlit%2C+M%3BWills%2C+S%3BAshwood%2C+P&rft.aulast=Van+De+Water&rft.aufirst=J.A.&rft.date=2006-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+International+Congress+on+Autoimmunity&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/autoimmunity/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Regulation of Cell Death and Lymphocyte Function T2 - 5th International Congress on Autoimmunity AN - 39260809; 4498439 JF - 5th International Congress on Autoimmunity AU - Lenardo, M AU - Bidere, N Y1 - 2006/11/29/ PY - 2006 DA - 2006 Nov 29 KW - Mortality KW - Lymphocytes KW - Cell death KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+International+Congress+on+Autoimmunity&rft.atitle=Molecular+Regulation+of+Cell+Death+and+Lymphocyte+Function&rft.au=Lenardo%2C+M%3BBidere%2C+N&rft.aulast=Lenardo&rft.aufirst=M&rft.date=2006-11-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+International+Congress+on+Autoimmunity&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/autoimmunity/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Reversal of drug resistance in P-glycoprotein-expressing T-cell acute lymphoblastic CEM leukemia cells by copper N-(2-hydroxy acetophenone) glycinate and oxalyl bis (N-phenyl) hydroxamic acid. AN - 68934800; 16410038 AB - Multiple drug resistance (MDR) represents a major obstacle to successful application of chemotherapy and a basic problem in cancer biology. MDR occurs at the cellular level and is multi-factorial in nature. The multidrug resistance gene, MDR1, and its gene product P-glycoprotein (P-gp) are now well known as an important determinant of MDR. Much effort has been devoted to develop P-gp inhibitors to modulate resistance. However, most of these resistance-modifying agents (RMA) are too toxic at the required doses. Therefore, the development of novel RMAs to overcome MDR represents a major challenge to modern cancer chemotherapy. In the present investigation, we describe the effect of oxalyl bis (N-phenyl) hydroxamic acid (OBPHA) and copper N-(2-hydroxy acetophenone) glycinate (CuNG) on multidrug-resistant P-gp-expressing CEM/ADR5000 T-cell acute lymphoblastic leukemia cells. CuNG, a known depleting agent for glutathione (GSH) and inhibitor of glutathione S-transferase (GST) and multidrug resistance-related protein 1 (MRP1), also inhibited P-gp-mediated doxorubicin accumulation and retention. The resistance-modifying effects of OBPHA were stronger than that of CuNG. Both novel RMAs overcame drug resistance more efficiently than verapamil, a well-known P-gp inhibitor. OBPHA and CuNG exposure resulted in an increased doxorubicin accumulation after 1-3h incubation by down-regulation of P-gp expression after 24h incubation. This is a clue that different mechanisms may contribute to modulation of P-gp-mediated drug resistance by these compounds. JF - Cancer letters AU - Majumder, S AU - Dutta, P AU - Mukherjee, P AU - Datta, E R AU - Efferth, T AU - Bhattacharya, S AU - Choudhuri, S K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta 700026, India. Y1 - 2006/11/28/ PY - 2006 DA - 2006 Nov 28 SP - 16 EP - 23 VL - 244 IS - 1 SN - 0304-3835, 0304-3835 KW - Antibiotics, Antineoplastic KW - 0 KW - Benzeneacetamides KW - Calcium Channel Blockers KW - Hydroxamic Acids KW - Organometallic Compounds KW - Oxalates KW - P-Glycoprotein KW - copper (N-2-hydroxyacetophenone)glycinate KW - oxalyl bis(N-phenyl)hydroxamic acid KW - Doxorubicin KW - 80168379AG KW - Verapamil KW - CJ0O37KU29 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Tumor Cells, Cultured KW - Doxorubicin -- pharmacology KW - Calcium Channel Blockers -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Humans KW - Verapamil -- pharmacology KW - Benzeneacetamides -- pharmacology KW - Oxalates -- pharmacology KW - Organometallic Compounds -- pharmacology KW - P-Glycoprotein -- metabolism KW - Glycine -- pharmacology KW - Leukemia-Lymphoma, Adult T-Cell -- metabolism KW - Drug Resistance, Multiple -- drug effects KW - Drug Resistance, Neoplasm KW - Leukemia-Lymphoma, Adult T-Cell -- drug therapy KW - Glycine -- analogs & derivatives KW - Hydroxamic Acids -- pharmacology KW - P-Glycoprotein -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68934800?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Reversal+of+drug+resistance+in+P-glycoprotein-expressing+T-cell+acute+lymphoblastic+CEM+leukemia+cells+by+copper+N-%282-hydroxy+acetophenone%29+glycinate+and+oxalyl+bis+%28N-phenyl%29+hydroxamic+acid.&rft.au=Majumder%2C+S%3BDutta%2C+P%3BMukherjee%2C+P%3BDatta%2C+E+R%3BEfferth%2C+T%3BBhattacharya%2C+S%3BChoudhuri%2C+S+K&rft.aulast=Majumder&rft.aufirst=S&rft.date=2006-11-28&rft.volume=244&rft.issue=1&rft.spage=16&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-25 N1 - Date created - 2006-10-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways. AN - 68165046; 17012228 AB - Three highly homologous small ubiquitin-related modifier (SUMO) proteins have been identified in mammals. Modifications of proteins by SUMO-1 have been shown to regulate transcription, nucleocytoplasmic transport, protein stability, and protein-protein interactions. Relative to SUMO-1, little is known about the functions of SUMO-2 or SUMO-3 (referred to as SUMO-2/3). Here, stable cell lines overexpressing processed forms of SUMO-2/3 (SUMO-2/3GG) as well as their non-conjugatable derivatives, SUMO-2/3DeltaGG, were established. Cells overexpressing SUMO-2/3GG showed a premature senescence phenotype as revealed by cellular morphology and senescence-associated galactosidase activity. The senescence pathway protein p21 was up-regulated in cells overexpressing SUMO-2/3GG. In contrast, cells overexpressing non-conjugatable forms of SUMO-2/3DeltaGG showed neither an apparent senescent phenotype nor elevated p21. Both p53 and pRB were found to be modified by SUMO-2/3. Site-directed mutagenesis studies showed that Lys-386 of p53, the SUMO-1 modification site, is also the modification site for SUMO-2/3. In addition, H2O2 treatment of untransfected cells caused an increase in p53 sumoylation by SUMO-2/3, whereas that by SUMO-1 remained unchanged. Moreover, knocking down tumor suppressor proteins p53 or pRB using small interfering RNA significantly alleviated the premature senescence phenotypes in SUMO-2/3GG overexpressing cells. Together, our results reveal that p53 and pRB can be sumoylated by SUMO-2/3 in vivo, and such modification of p53 and pRB may play roles in premature senescence and stress response. JF - The Journal of biological chemistry AU - Li, Tianwei AU - Santockyte, Rasa AU - Shen, Rong-Fong AU - Tekle, Ephrem AU - Wang, Guanghui AU - Yang, David C H AU - Chock, P Boon AD - Laboratory of Biochemistry and Proteomics Core Facility, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/11/24/ PY - 2006 DA - 2006 Nov 24 SP - 36221 EP - 36227 VL - 281 IS - 47 SN - 0021-9258, 0021-9258 KW - RNA, Small Interfering KW - 0 KW - Retinoblastoma Protein KW - SUMO2 protein, human KW - SUMO2 protein, mouse KW - SUMO3 protein, human KW - Small Ubiquitin-Related Modifier Proteins KW - Sumo3 protein, mouse KW - Tumor Suppressor Protein p53 KW - Ubiquitins KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Animals KW - Cytoplasm -- metabolism KW - Cell Nucleus -- metabolism KW - Cell Aging KW - Humans KW - Mice KW - RNA, Small Interfering -- metabolism KW - NIH 3T3 Cells KW - Ubiquitins -- physiology KW - Retinoblastoma Protein -- metabolism KW - Gene Expression Regulation KW - Tumor Suppressor Protein p53 -- metabolism KW - Small Ubiquitin-Related Modifier Proteins -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68165046?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Expression+of+SUMO-2%2F3+induced+senescence+through+p53-+and+pRB-mediated+pathways.&rft.au=Li%2C+Tianwei%3BSantockyte%2C+Rasa%3BShen%2C+Rong-Fong%3BTekle%2C+Ephrem%3BWang%2C+Guanghui%3BYang%2C+David+C+H%3BChock%2C+P+Boon&rft.aulast=Li&rft.aufirst=Tianwei&rft.date=2006-11-24&rft.volume=281&rft.issue=47&rft.spage=36221&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal Pulse Oximetry and Cesarean Delivery AN - 223926681; 17124017 AB - Background Knowledge of fetal oxygen saturation, as an adjunct to electronic fetal monitoring, may be associated with a significant change in the rate of cesarean deliveries or the infant's condition at birth. Methods We randomly assigned 5341 nulliparous women who were at term and in early labor to either "open" or "masked" fetal pulse oximetry. In the open group, fetal oxygen saturation values were displayed to the clinician. In the masked group, the fetal oxygen sensor was inserted and the values were recorded by computer, but the data were hidden. Labor complicated by a nonreassuring fetal heart rate before randomization was documented for subsequent analysis. Results There was no significant difference in the overall rates of cesarean delivery between the open and masked groups (26.3% and 27.5%, respectively; P=0.31). The rates of cesarean delivery associated with the separate indications of a nonreassuring fetal heart rate (7.1% and 7.9%, respectively; P=0.30) and dystocia (18.6% and 19.2%, respectively; P=0.59) were similar between the two groups. Similar findings were observed in the subgroup of 2168 women in whom a nonreassuring fetal heart rate was detected before randomization. The condition of the infants at birth did not differ significantly between the two groups. Conclusions Knowledge of the fetal oxygen saturation is not associated with a reduction in the rate of cesarean delivery or with improvement in the condition of the newborn. (ClinicalTrials.gov number, NCT00098709 .) JF - The New England Journal of Medicine AU - Bloom, Steven L, MD AU - Spong, Catherine Y, MD AU - Thom, Elizabeth, PhD AU - Varner, Michael W, MD AU - Rouse, Dwight J, MD AU - Weininger, Sandy, PhD AU - Ramin, Susan M, MD AU - Caritis, Steve N, MD AU - Peaceman, Alan, MD AU - Sorokin, Yoram, MD AU - Sciscione, Anthony, MD AU - Carpenter, Marshall, MD AU - Mercer, Brian, MD AU - Thorp, John, MD AU - Malone, Fergal, MD AU - Harper, Margaret, MD AU - Iams, Jay, MD AU - Anderson, Garland, MD Y1 - 2006/11/23/ PY - 2006 DA - 2006 Nov 23 SP - 2195 EP - 202 CY - Boston PB - Massachusetts Medical Society VL - 355 IS - 21 SN - 00284793 KW - Medical Sciences KW - Pregnancy KW - Cesarean section KW - Births KW - Obstetrics KW - Oxygen KW - Prenatal development KW - Women KW - Delivery, Obstetric KW - Asphyxia -- diagnosis KW - Dystocia KW - Heart Rate, Fetal KW - Humans KW - Adult KW - Infant, Newborn KW - Fetal Diseases -- diagnosis KW - Female KW - Pregnancy Outcome KW - Fetal Monitoring KW - Cesarean Section -- statistics & numerical data KW - Oximetry -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/223926681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=Fetal+Pulse+Oximetry+and+Cesarean+Delivery&rft.au=Bloom%2C+Steven+L%2C+MD%3BSpong%2C+Catherine+Y%2C+MD%3BThom%2C+Elizabeth%2C+PhD%3BVarner%2C+Michael+W%2C+MD%3BRouse%2C+Dwight+J%2C+MD%3BWeininger%2C+Sandy%2C+PhD%3BRamin%2C+Susan+M%2C+MD%3BCaritis%2C+Steve+N%2C+MD%3BPeaceman%2C+Alan%2C+MD%3BSorokin%2C+Yoram%2C+MD%3BSciscione%2C+Anthony%2C+MD%3BCarpenter%2C+Marshall%2C+MD%3BMercer%2C+Brian%2C+MD%3BThorp%2C+John%2C+MD%3BMalone%2C+Fergal%2C+MD%3BHarper%2C+Margaret%2C+MD%3BIams%2C+Jay%2C+MD%3BAnderson%2C+Garland%2C+MD&rft.aulast=Bloom&rft.aufirst=Steven&rft.date=2006-11-23&rft.volume=355&rft.issue=21&rft.spage=2195&rft.isbn=&rft.btitle=&rft.title=The+New+England+Journal+of+Medicine&rft.issn=00284793&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright © 2006 Massachusetts Medical Society. All rights reserved. N1 - Document feature - Charts; Tables; References N1 - Last updated - 2014-03-28 N1 - CODEN - NEJMAG ER - TY - JOUR T1 - Somatodendritic Kv7/KCNQ/M channels control interspike interval in hippocampal interneurons. AN - 68183593; 17122058 AB - The M-current (I(M)), comprised of Kv7 channels, is a voltage-activated K+ conductance that plays a key role in the control of cell excitability. In hippocampal principal cells, I(M) controls action potential (AP) accommodation and contributes to the medium-duration afterhyperpolarization, but the role of I(M) in control of interneuron excitability remains unclear. Here, we investigated I(M) in hippocampal stratum oriens (SO) interneurons, both from wild-type and transgenic mice in which green fluorescent protein (GFP) was expressed in somatostatin-containing interneurons. Somatodendritic expression of Kv7.2 or Kv7.3 subunits was colocalized in a subset of GFP+ SO interneurons, corresponding to oriens-lacunosum moleculare (O-LM) cells. Under voltage clamp (VC) conditions at -30 mV, the Kv7 channel antagonists linopirdine/XE-991 abolished the I(M) amplitude present during relaxation from -30 to -50 mV and reduced the holding current (I(hold)). In addition, 0.5 mM tetraethylammonium reduced I(M), suggesting that I(M) was composed of Kv7.2-containing channels. In contrast, the Kv7 channel opener retigabine increased I(M) amplitude and I(hold). When strongly depolarized in VC, the linopirdine-sensitive outward current activated rapidly and comprised up to 20% of the total current. In current-clamp recordings from GFP+ SO cells, linopirdine induced depolarization and increased AP frequency, whereas retigabine induced hyperpolarization and arrested firing. In multicompartment O-LM interneuron models that incorporated I(M), somatodendritic placement of Kv7 channels best reproduced experimentally measured I(M). The models suggest that Kv3- and Kv7-mediated channels both rapidly activate during single APs; however, Kv3 channels control rapid repolarization of the AP, whereas Kv7 channels primarily control the interspike interval. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Lawrence, J Josh AU - Saraga, Fernanda AU - Churchill, Joseph F AU - Statland, Jeffrey M AU - Travis, Katherine E AU - Skinner, Frances K AU - McBain, Chris J AD - Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. lawrenjo@mail.nih.gov Y1 - 2006/11/22/ PY - 2006 DA - 2006 Nov 22 SP - 12325 EP - 12338 VL - 26 IS - 47 KW - 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone KW - 0 KW - Anthracenes KW - Carbamates KW - Indoles KW - KCNQ Potassium Channels KW - Phenylenediamines KW - Potassium Channel Blockers KW - Pyridines KW - linopirdine KW - 105431-72-9 KW - ezogabine KW - 12G01I6BBU KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Tetraethylammonium KW - 66-40-0 KW - Index Medicus KW - Carbamates -- pharmacology KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Membrane Potentials -- radiation effects KW - Tetraethylammonium -- pharmacology KW - Humans KW - Membrane Potentials -- physiology KW - Mice, Transgenic KW - Green Fluorescent Proteins -- genetics KW - In Vitro Techniques KW - Models, Neurological KW - Phenylenediamines -- pharmacology KW - Green Fluorescent Proteins -- metabolism KW - Patch-Clamp Techniques -- methods KW - Computer Simulation KW - Anthracenes -- pharmacology KW - Immunohistochemistry -- methods KW - Mice KW - Dose-Response Relationship, Radiation KW - Transfection -- methods KW - Potassium Channel Blockers -- pharmacology KW - Indoles -- pharmacology KW - Membrane Potentials -- drug effects KW - Pyridines -- pharmacology KW - Cell Line KW - Action Potentials -- physiology KW - Hippocampus -- cytology KW - Interneurons -- physiology KW - KCNQ Potassium Channels -- metabolism KW - KCNQ Potassium Channels -- classification KW - Dendrites -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68183593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Somatodendritic+Kv7%2FKCNQ%2FM+channels+control+interspike+interval+in+hippocampal+interneurons.&rft.au=Lawrence%2C+J+Josh%3BSaraga%2C+Fernanda%3BChurchill%2C+Joseph+F%3BStatland%2C+Jeffrey+M%3BTravis%2C+Katherine+E%3BSkinner%2C+Frances+K%3BMcBain%2C+Chris+J&rft.aulast=Lawrence&rft.aufirst=J&rft.date=2006-11-22&rft.volume=26&rft.issue=47&rft.spage=12325&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolution and expression of chimeric POTE-actin genes in the human genome. AN - 68177952; 17101985 AB - We previously described a primate-specific gene family, POTE, that is expressed in many cancers but in a limited number of normal organs. The 13 POTE genes are dispersed among eight different chromosomes and evolved by duplications and remodeling of the human genome from an ancestral gene, ANKRD26. Based on sequence similarity, the POTE gene family members can be divided into three groups. By genome database searches, we identified an actin retroposon insertion at the carboxyl terminus of one of the ancestral POTE paralogs. By Northern blot analysis, we identified the expected 7.5-kb POTE-actin chimeric transcript in a breast cancer cell line. The protein encoded by the POTE-actin transcript is predicted to be 120 kDa in size. Using anti-POTE mAbs that recognize the amino-terminal portion of the POTE protein, we detected the 120-kDa POTE-actin fusion protein in breast cancer cell lines known to express the fusion transcript. These data demonstrate that insertion of a retroposon produced an altered functional POTE gene. This example indicates that new functional human genes can evolve by insertion of retroposons. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Lee, Yoomi AU - Ise, Tomoko AU - Ha, Duc AU - Saint Fleur, Ashley AU - Hahn, Yoonsoo AU - Liu, Xiu-Fen AU - Nagata, Satoshi AU - Lee, Byungkook AU - Bera, Tapan K AU - Pastan, Ira AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4264, USA. Y1 - 2006/11/21/ PY - 2006 DA - 2006 Nov 21 SP - 17885 EP - 17890 VL - 103 IS - 47 SN - 0027-8424, 0027-8424 KW - Actins KW - 0 KW - Proteins KW - Recombinant Fusion Proteins KW - Retroelements KW - Index Medicus KW - Phylogeny KW - Animals KW - Base Sequence KW - Sequence Alignment KW - Humans KW - Molecular Sequence Data KW - Breast Neoplasms KW - Cell Line, Tumor KW - Tissue Distribution KW - Mutagenesis, Insertional KW - Haplorhini KW - Female KW - Recombinant Fusion Proteins -- metabolism KW - Proteins -- chemistry KW - Genome, Human KW - Actins -- genetics KW - Multigene Family KW - Recombinant Fusion Proteins -- genetics KW - Actins -- metabolism KW - Proteins -- metabolism KW - Proteins -- genetics KW - Evolution, Molecular UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Evolution+and+expression+of+chimeric+POTE-actin+genes+in+the+human+genome.&rft.au=Lee%2C+Yoomi%3BIse%2C+Tomoko%3BHa%2C+Duc%3BSaint+Fleur%2C+Ashley%3BHahn%2C+Yoonsoo%3BLiu%2C+Xiu-Fen%3BNagata%2C+Satoshi%3BLee%2C+Byungkook%3BBera%2C+Tapan+K%3BPastan%2C+Ira&rft.aulast=Lee&rft.aufirst=Yoomi&rft.date=2006-11-21&rft.volume=103&rft.issue=47&rft.spage=17885&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2001 Oct;21(19):6507-14 [11533239] Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3220-5 [16492757] Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4448-53 [11904380] Science. 2001 Feb 16;291(5507):1293-7 [11181993] Genomics. 2002 May;79(5):628-34 [11991712] Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16975-80 [12475935] Nat Rev Genet. 2003 Nov;4(11):865-75 [14634634] Gene. 2004 Jan 21;325:103-13 [14697515] Science. 2004 Mar 12;303(5664):1626-32 [15016989] Gene. 2004 Aug 4;337:45-53 [15276201] Nature. 2004 Jul 29;430(6999):569-73 [15243629] Mol Carcinog. 1992;6(1):43-52 [1354442] Science. 1993 Apr 2;260(5104):91-5 [7682012] Genome Res. 1999 Sep;9(9):868-77 [10508846] Am J Hum Genet. 2005 May;76(5):717-28 [15806441] Nature. 2005 Jun 16;435(7044):903-10 [15959507] Genome Res. 2005 Aug;15(8):1073-8 [16024818] Cancer Res. 2006 Jan 1;66(1):52-6 [16397215] Gene. 2006 Feb 1;366(2):238-45 [16364570] Mol Biol Evol. 2002 Jan;19(1):110-7 [11752196] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lipid defect underlies selective skin barrier impairment of an epidermal-specific deletion of Gata-3. AN - 68172404; 17116754 AB - Skin lies at the interface between the complex physiology of the body and the external environment. This essential epidermal barrier, composed of cornified proteins encased in lipids, prevents both water loss and entry of infectious or toxic substances. We uncover that the transcription factor GATA-3 is required to establish the epidermal barrier and survive in the ex utero environment. Analysis of Gata-3 mutant transcriptional profiles at three critical developmental stages identifies a specific defect in lipid biosynthesis and a delay in differentiation. Genomic analysis identifies highly conserved GATA-3 binding sites bound in vivo by GATA-3 in the first intron of the lipid acyltransferase gene AGPAT5. Skin from both Gata-3-/- and previously characterized barrier-deficient Kruppel-like factor 4-/- newborns up-regulate antimicrobial peptides, effectors of innate immunity. Comparison of these animal models illustrates how impairment of the skin barrier by two genetically distinct mechanisms leads to innate immune responses, as observed in the common human skin disorders psoriasis and atopic dermatitis. JF - The Journal of cell biology AU - de Guzman Strong, Cristina AU - Wertz, Philip W AU - Wang, Chenwei AU - Yang, Fan AU - Meltzer, Paul S AU - Andl, Thomas AU - Millar, Sarah E AU - Ho, I-Cheng AU - Pai, Sung-Yun AU - Segre, Julia A AD - National Human Genome Research Institute and 2National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/11/20/ PY - 2006 DA - 2006 Nov 20 SP - 661 EP - 670 VL - 175 IS - 4 SN - 0021-9525, 0021-9525 KW - GATA3 Transcription Factor KW - 0 KW - GKLF protein KW - Keratin-13 KW - Kruppel-Like Transcription Factors KW - Index Medicus KW - Embryonic Development KW - Animals KW - Immunity, Innate -- immunology KW - Skin Transplantation KW - Cell Differentiation KW - Transcription, Genetic KW - Mice KW - Keratin-13 -- metabolism KW - Cell Proliferation KW - Protein Binding KW - Introns -- genetics KW - Binding Sites KW - Exons -- genetics KW - Animals, Newborn KW - Base Sequence KW - Embryo, Mammalian -- embryology KW - Molecular Sequence Data KW - Kruppel-Like Transcription Factors -- genetics KW - Epidermis -- physiopathology KW - GATA3 Transcription Factor -- genetics KW - Epidermis -- abnormalities KW - GATA3 Transcription Factor -- deficiency KW - Lipid Metabolism KW - Epidermis -- ultrastructure KW - Epidermis -- embryology KW - Gene Deletion KW - GATA3 Transcription Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68172404?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+cell+biology&rft.atitle=Lipid+defect+underlies+selective+skin+barrier+impairment+of+an+epidermal-specific+deletion+of+Gata-3.&rft.au=de+Guzman+Strong%2C+Cristina%3BWertz%2C+Philip+W%3BWang%2C+Chenwei%3BYang%2C+Fan%3BMeltzer%2C+Paul+S%3BAndl%2C+Thomas%3BMillar%2C+Sarah+E%3BHo%2C+I-Cheng%3BPai%2C+Sung-Yun%3BSegre%2C+Julia+A&rft.aulast=de+Guzman+Strong&rft.aufirst=Cristina&rft.date=2006-11-20&rft.volume=175&rft.issue=4&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+cell+biology&rft.issn=00219525&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-25 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Arch Oral Biol. 1995 Dec;40(12):1085-91 [8850646] Nat Genet. 1995 Sep;11(1):40-4 [7550312] Development. 1998 Apr;125(8):1541-52 [9502735] Chem Phys Lipids. 1998 Feb;91(2):85-96 [9569614] Annu Rev Immunol. 1999;17:149-87 [10358756] J Biol Chem. 1999 Jul 23;274(30):21180-5 [10409672] Nat Genet. 1999 Aug;22(4):356-60 [10431239] Differentiation. 2004 Oct;72(8):364-70 [15606495] Biochem J. 2005 Jan 15;385(Pt 2):469-77 [15367102] J Med Genet. 2005 Jun;42(6):e37 [15937077] Nucleic Acids Res. 2000 Jan 1;28(1):316-9 [10592259] Blood. 2000 Mar 1;95(5):1652-5 [10688820] J Cell Biol. 2000 Oct 16;151(2):389-400 [11038185] Development. 2001 Aug;128(15):2867-80 [11532911] Mol Cell Biol. 2001 Oct;21(20):7047-53 [11564887] J Invest Dermatol. 2005 Jul;125(1):viii-ix; discussion x-xi [15982292] J Invest Dermatol. 2005 Jul;125(1):9-13 [15982297] J Invest Dermatol. 2005 Aug;125(2):183-200 [16098026] Nature. 2005 Sep 8;437(7056):275-80 [16094321] Dev Cell. 2005 Dec;9(6):855-61 [16326396] Nat Med. 2005 Dec;11(12):1351-4 [16288281] J Invest Dermatol. 2005 Dec;125(6):1163-73 [16354186] Immunity. 2006 Mar;24(3):341-8 [16546102] Nat Genet. 2006 Apr;38(4):441-6 [16550169] J Clin Invest. 2006 May;116(5):1150-8 [16670755] Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13031-6 [11698679] J Cell Biol. 2002 Mar 18;156(6):1099-111 [11889141] Development. 2002 May;129(9):2233-46 [11959831] Oncogene. 2002 May 23;21(23):3765-79 [12032844] N Engl J Med. 2002 Oct 10;347(15):1199-200 [12374882] Br J Dermatol. 2002 Dec;147(6):1127-34 [12452861] Nature. 2002 Dec 5;420(6915):520-62 [12466850] Development. 2003 Jun;130(12):2767-77 [12736219] Nucleic Acids Res. 2003 May 15;31(10):e57 [12736323] Nucleic Acids Res. 2003 Jul 1;31(13):3518-24 [12824357] Genes Dev. 2003 Sep 1;17(17):2108-22 [12923059] J Cell Biol. 2003 Oct 27;163(2):327-37 [14568992] J Cell Biol. 2003 Nov 24;163(4):901-10 [14638864] Immunity. 2003 Dec;19(6):863-75 [14670303] Science. 2004 Jan 16;303(5656):359-63 [14671312] Nat Biotechnol. 2004 Apr;22(4):411-7 [15024388] Development. 2004 May;131(10):2257-68 [15102710] Cell. 2004 Sep 3;118(5):635-48 [15339667] Curr Opin Cell Biol. 2004 Oct;16(5):486-92 [15363797] Curr Opin Genet Dev. 2004 Oct;14(5):485-91 [15380238] Mol Carcinog. 1988;1(2):96-108 [3076454] J Clin Invest. 1991 May;87(5):1668-73 [2022737] Pediatr Res. 1992 Oct;32(4):494-8 [1437405] J Clin Invest. 1993 Jun;91(6):2703-8 [8514877] Mol Cell Biol. 1993 Jul;13(7):3999-4010 [8321207] J Clin Invest. 1994 Apr;93(4):1756-64 [8163674] Development. 1994 Sep;120(9):2369-83 [7525178] Genes Dev. 1997 Jul 1;11(13):1651-61 [9224715] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Copper toxicity across salinities from freshwater to seawater in the euryhaline fish Fundulus heteroclitus: is copper an ionoregulatory toxicant in high salinities? AN - 68985714; 16996624 AB - Two waterborne Cu exposures were performed to investigate if Cu is an ionoregulatory toxicant at all salinities in the killifish, Fundulus heteroclitus. A 30-day flow through exposure in 0 (FW), 5, 11, 22, and 28 ppt (SW) and three [Cu]'s (nominal 0, 30, and 150 microg Cu L(-1)) revealed no apparent Cu induced mortality at the intermediate salinities and high mortality in FW and SW. Fish were sampled at 4, 12, and 30 days after the start of the exposure and both Na+/K+ adenosine triphosphatase (Na+/K+ ATPase) and carbonic anhydrase (CA) activity in the gill and intestine as well as whole body [Na+], and [Cl-] were measured. At the high [Cu] a reduction of whole body [Na+] after 4 days of exposure in FW was the only physiological parameter influenced. A second static 24h Cu exposure was performed in FW, 5, 13, and 29 ppt (SW) and two [Cu]'s (nominal 0 and 110 microg Cu L(-1)). In addition to the parameters listed above, ammonia flux was measured at all salinities and Na+ flux was measured in FW fish. Cu affected ionoregulation in FW where decreased Na+ uptake associated with inhibition of Na+/K+ ATPase led to decreased whole body [Na+] after 24h. The only affected parameter in SW was net ammonia excretion suggesting that Cu is not an ionoregulatory toxicant in SW at the concentrations employed. We propose that physiology rather than chemistry explain much of the variation in Cu toxicity seen across salinities. JF - Aquatic toxicology (Amsterdam, Netherlands) AU - Blanchard, Jonathan AU - Grosell, Martin AD - Rosenstiel School of Marine and Atmospheric Science, Division of Marine Biology and Fisheries, NIEHS Marine and Freshwater Biomedical Sciences Center, University of Miami, 4600 Rickenbacker Cswy, Miami, FL 33149, USA. jblanchard@rsmas.miami.edu Y1 - 2006/11/16/ PY - 2006 DA - 2006 Nov 16 SP - 131 EP - 139 VL - 80 IS - 2 SN - 0166-445X, 0166-445X KW - Water Pollutants, Chemical KW - 0 KW - Sodium Chloride KW - 451W47IQ8X KW - Chlorine KW - 4R7X1O2820 KW - Ammonia KW - 7664-41-7 KW - Copper KW - 789U1901C5 KW - Sodium KW - 9NEZ333N27 KW - Adenosine Triphosphatases KW - EC 3.6.1.- KW - Carbonic Anhydrases KW - EC 4.2.1.1 KW - Index Medicus KW - Animals KW - Adenosine Triphosphatases -- drug effects KW - Intestines -- drug effects KW - Chlorine -- analysis KW - Ammonia -- analysis KW - Sodium -- analysis KW - Sodium Chloride -- analysis KW - Adenosine Triphosphatases -- analysis KW - Carbonic Anhydrases -- drug effects KW - Time Factors KW - Gills -- drug effects KW - Carbonic Anhydrases -- analysis KW - Survival Analysis KW - Seawater -- chemistry KW - Fresh Water -- chemistry KW - Water Pollutants, Chemical -- toxicity KW - Fundulidae -- physiology KW - Copper -- analysis KW - Copper -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68985714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.atitle=Copper+toxicity+across+salinities+from+freshwater+to+seawater+in+the+euryhaline+fish+Fundulus+heteroclitus%3A+is+copper+an+ionoregulatory+toxicant+in+high+salinities%3F&rft.au=Blanchard%2C+Jonathan%3BGrosell%2C+Martin&rft.aulast=Blanchard&rft.aufirst=Jonathan&rft.date=2006-11-16&rft.volume=80&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Aquatic+toxicology+%28Amsterdam%2C+Netherlands%29&rft.issn=0166445X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-01 N1 - Date created - 2006-10-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Visualization of transient encounter complexes in protein-protein association. AN - 68151209; 17051159 AB - Kinetic data on a number of protein-protein associations have provided evidence for the initial formation of a pre-equilibrium encounter complex that subsequently relaxes to the final stereospecific complex. Site-directed mutagenesis and brownian dynamics simulations have suggested that the rate of association can be modulated by perturbations in charge distribution outside the direct interaction surfaces. Furthermore, rate enhancement through non-specific binding may occur by either a reduction in dimensionality or the presence of a short-range, non-specific attractive potential. Here, using paramagnetic relaxation enhancement, we directly demonstrate the existence and visualize the distribution of an ensemble of transient, non-specific encounter complexes under equilibrium conditions for a relatively weak protein-protein complex between the amino-terminal domain of enzyme I and the phosphocarrier protein HPr. Neither the stereospecific complex alone nor any single alternative conformation can account fully for the intermolecular paramagnetic relaxation enhancement data. Restrained rigid-body simulated annealing refinement against the paramagnetic relaxation enhancement data enables us to obtain an atomic probability distribution map of the non-specific encounter complex ensemble that qualitatively correlates with the electrostatic surface potentials on the interacting proteins. Qualitatively similar results are presented for two other protein-protein complexes. JF - Nature AU - Tang, Chun AU - Iwahara, Junji AU - Clore, G Marius AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, USA. Y1 - 2006/11/16/ PY - 2006 DA - 2006 Nov 16 SP - 383 EP - 386 VL - 444 IS - 7117 KW - Bacterial Proteins KW - 0 KW - Enzymes KW - Multiprotein Complexes KW - Phosphoenolpyruvate Sugar Phosphotransferase System KW - EC 2.7.1.- KW - phosphocarrier protein HPr KW - Index Medicus KW - Static Electricity KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Multiprotein Complexes -- chemistry KW - Kinetics KW - Protein Binding KW - Protein Conformation KW - Multiprotein Complexes -- metabolism KW - Bacterial Proteins -- chemistry KW - Phosphoenolpyruvate Sugar Phosphotransferase System -- chemistry KW - Phosphoenolpyruvate Sugar Phosphotransferase System -- metabolism KW - Bacterial Proteins -- metabolism KW - Enzymes -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68151209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Visualization+of+transient+encounter+complexes+in+protein-protein+association.&rft.au=Tang%2C+Chun%3BIwahara%2C+Junji%3BClore%2C+G+Marius&rft.aulast=Tang&rft.aufirst=Chun&rft.date=2006-11-16&rft.volume=444&rft.issue=7117&rft.spage=383&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Nature. 2006 Nov 16;444(7117):279-80 [17051147] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A novel copper complex induces ROS generation in doxorubicin resistant Ehrlich ascitis carcinoma cells and increases activity of antioxidant enzymes in vital organs in vivo. AN - 68180353; 17107616 AB - In search of a suitable GSH-depleting agent, a novel copper complex viz., copper N-(2-hydroxyacetophenone) glycinate (CuNG) has been synthesized, which was initially found to be a potential resistance modifying agent and later found to be an immunomodulator in mice model in different doses. The objective of the present work was to decipher the effect of CuNG on reactive oxygen species (ROS) generation and antioxidant enzymes in normal and doxorubicin-resistant Ehrlich ascites carcinoma (EAC/Dox)-bearing Swiss albino mice. The effect of CuNG has been studied on ROS generation, multidrug resistance-associated protein1 (MRP1) expression and on activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). CuNG increased ROS generation and reduced MRP1 expression in EAC/Dox cells while only temporarily depleted glutathione (GSH) within 2 h in heart, kidney, liver and lung of EAC/Dox bearing mice, which were restored within 24 h. The level of liver Cu was observed to be inversely proportional to the level of GSH. Moreover, CuNG modulated SOD, CAT and GPx in different organs and thereby reduced oxidative stress. Thus nontoxic dose of CuNG may be utilized to reduce MRP1 expression and thus sensitize EAC/Dox cells to standard chemotherapy. Moreover, CuNG modulated SOD, CAT and and GPx activities to reduce oxidative stress in some vital organs of EAC/Dox bearing mice. CuNG treatment also helped to recover liver and renal function in EAC/Dox bearing mice. Based on our studies, we conclude that CuNG may be a promising candidate to sensitize drug resistant cancers in the clinic. JF - BMC cancer AU - Mookerjee, Ananda AU - Basu, Jayati Mookerjee AU - Majumder, Surajit AU - Chatterjee, Shilpak AU - Panda, Gouri S AU - Dutta, Pranabananda AU - Pal, Smarajit AU - Mukherjee, Pratima AU - Efferth, Thomas AU - Roy, Syamal AU - Choudhuri, Soumitra K AD - Department of Environmental Carcinogenesis and Toxicology, Chittaranjan National Cancer Institute (CNCI), 37 S, P, Mukherjee Road, Calcutta-700026, India. anandamookerjee@yahoo.com Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 SP - 267 VL - 6 KW - Antibiotics, Antineoplastic KW - 0 KW - Multidrug Resistance-Associated Proteins KW - Organometallic Compounds KW - Reactive Oxygen Species KW - copper (N-2-hydroxyacetophenone)glycinate KW - Doxorubicin KW - 80168379AG KW - Catalase KW - EC 1.11.1.6 KW - Glutathione Peroxidase KW - EC 1.11.1.9 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Glycine KW - TE7660XO1C KW - multidrug resistance-associated protein 1 KW - Y49M64GZ4Q KW - Index Medicus KW - Catalase -- metabolism KW - Animals KW - Glutathione Peroxidase -- metabolism KW - Multidrug Resistance-Associated Proteins -- metabolism KW - Superoxide Dismutase -- metabolism KW - Mice KW - Drug Resistance, Neoplasm KW - Organometallic Compounds -- pharmacology KW - Doxorubicin -- pharmacology KW - Glycine -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Glycine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68180353?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=A+novel+copper+complex+induces+ROS+generation+in+doxorubicin+resistant+Ehrlich+ascitis+carcinoma+cells+and+increases+activity+of+antioxidant+enzymes+in+vital+organs+in+vivo.&rft.au=Mookerjee%2C+Ananda%3BBasu%2C+Jayati+Mookerjee%3BMajumder%2C+Surajit%3BChatterjee%2C+Shilpak%3BPanda%2C+Gouri+S%3BDutta%2C+Pranabananda%3BPal%2C+Smarajit%3BMukherjee%2C+Pratima%3BEfferth%2C+Thomas%3BRoy%2C+Syamal%3BChoudhuri%2C+Soumitra+K&rft.aulast=Mookerjee&rft.aufirst=Ananda&rft.date=2006-11-15&rft.volume=6&rft.issue=&rft.spage=267&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-26 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Ann Hepatol. 2004 Jul-Sep;3(3):86-92 [15505592] Toxicology. 2006 Jan 16;217(2-3):155-68 [16221516] Anal Biochem. 1971 Nov;44(1):276-87 [4943714] J Nutr. 1974 May;104(5):580-7 [4823943] Anal Biochem. 1976 May 7;72:248-54 [942051] Cancer Treat Rep. 1985 Jun;69(6):677-82 [4016771] J Pharmacol Exp Ther. 1985 Aug;234(2):498-506 [4020683] Jpn J Cancer Res. 1989 Jan;80(1):89-94 [2496064] Cancer Res. 1990 Oct 15;50(20):6449-54 [2208103] Redox Rep. 2005;10(5):237-45 [16354412] Chem Biol Interact. 2006 Feb 1;159(2):90-103 [16289015] J Cardiovasc Pharmacol. 2006 Jan;47(1):158-63 [16424801] Mutat Res. 2006 Jan 29;593(1-2):64-79 [16085125] Indian J Physiol Pharmacol. 2005 Jul-Sep;49(3):341-4 [16440854] Chem Biol Interact. 2006 Mar 10;160(1):1-40 [16430879] Med Chem. 2005 Nov;1(6):563-73 [16787340] Clin Cancer Res. 2006 Jul 15;12(14 Pt 1):4339-49 [16857809] Cancer Lett. 2006 Nov 28;244(1):16-23 [16410038] J Biol Chem. 2001 May 18;276(20):17420-8 [11279018] Cell Physiol Biochem. 2001;11(4):173-86 [11509825] Clin Exp Metastasis. 2002;19(8):681-7 [12553373] Eur J Med Chem. 2003 Oct;38(10):893-8 [14575936] Antioxid Redox Signal. 2004 Jun;6(3):561-70 [15130282] Cell Death Differ. 2004 Jul;11(7):737-46 [15002036] Int J Cancer. 2004 Nov 10;112(3):385-92 [15382062] Adv Exp Med Biol. 1990;264:45-50 [2173879] Toxicology. 1994 Sep 6;92(1-3):75-90 [7940570] Cell. 1994 Oct 21;79(2):315-28 [7525077] Hepatology. 1997 Apr;25(4):840-6 [9096586] Biochem Pharmacol. 1997 Sep 1;54(5):597-603 [9337076] Anticancer Drugs. 1998 Oct;9(9):825-32 [9840730] Blood. 2005 Feb 15;105(4):1724-33 [15486061] Chem Biol Interact. 2005 Jan 15;151(2):71-82 [15698579] Apoptosis. 2005 Jan;10(1):111-21 [15711927] Biochem Biophys Res Commun. 2005 Jul 1;332(2):433-40 [15896711] Free Radic Res. 2005 Sep;39(9):979-86 [16087479] Cancer Res. 2005 Aug 15;65(16):7436-45 [16103097] Anticancer Res. 2005 May-Jun;25(3B):1945-51 [16158929] Anal Biochem. 1968 Oct 24;25(1):192-205 [4973948] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Redox Reactions of Nitrite with oxy- and deoxy- hemoglobin and Myoglobin T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40537326; 4524308 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Grubina, Rozalina AU - Huang, Zhi AU - Shiva, Sruti AU - Gladwin, Mark T Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Nitrite KW - Myoglobin KW - Hemoglobin KW - Redox reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40537326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Redox+Reactions+of+Nitrite+with+oxy-+and+deoxy-+hemoglobin+and+Myoglobin&rft.au=Grubina%2C+Rozalina%3BHuang%2C+Zhi%3BShiva%2C+Sruti%3BGladwin%2C+Mark+T&rft.aulast=Grubina&rft.aufirst=Rozalina&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bigger Needles in Smaller Haystacks: Identifying the Site of Spin-Trapping in Proteins by a Combination of Liquid Chromatography, ELISA and Off-Line Tandem Mass Spectrometry. T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40536486; 4524186 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Lardinois, Olivier AU - Deterding, Leesa AU - Tomer, Kenneth AU - Mason, Ronald Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Mass spectroscopy KW - Liquid chromatography KW - ELISA KW - Chromatography KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40536486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Bigger+Needles+in+Smaller+Haystacks%3A+Identifying+the+Site+of+Spin-Trapping+in+Proteins+by+a+Combination+of+Liquid+Chromatography%2C+ELISA+and+Off-Line+Tandem+Mass+Spectrometry.&rft.au=Lardinois%2C+Olivier%3BDeterding%2C+Leesa%3BTomer%2C+Kenneth%3BMason%2C+Ronald&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metal Catalyzed Oxidation of mRNA Leads to Formation of Dysfunctional Polypeptides. T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40536381; 4524330 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Tanaka, Mikiei AU - Hirata, Yoko AU - Chock, Boon AU - Stadtman, Earl Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Oxidation KW - Metals KW - MRNA KW - Polypeptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40536381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Metal+Catalyzed+Oxidation+of+mRNA+Leads+to+Formation+of+Dysfunctional+Polypeptides.&rft.au=Tanaka%2C+Mikiei%3BHirata%2C+Yoko%3BChock%2C+Boon%3BStadtman%2C+Earl&rft.aulast=Tanaka&rft.aufirst=Mikiei&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitrite Mediates Both Classical and Long Term Preconditioning from Ischemia/Reperfusion Injury at the Mitochondrial Level T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40535689; 4524251 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Shiva, Sruti AU - Sack, Michael AU - Duranski, Mark AU - Ringwood, Lorna AU - Wang, Xunde AU - Raghavachari, Nalini AU - Macarthur, Peter AU - Burwell, Lindsey AU - Brookes, Paul AU - Lefer, David AU - Gladwin, Mark Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Nitrite KW - Injuries KW - Ischemia KW - Mitochondria KW - Reperfusion KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535689?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Nitrite+Mediates+Both+Classical+and+Long+Term+Preconditioning+from+Ischemia%2FReperfusion+Injury+at+the+Mitochondrial+Level&rft.au=Shiva%2C+Sruti%3BSack%2C+Michael%3BDuranski%2C+Mark%3BRingwood%2C+Lorna%3BWang%2C+Xunde%3BRaghavachari%2C+Nalini%3BMacarthur%2C+Peter%3BBurwell%2C+Lindsey%3BBrookes%2C+Paul%3BLefer%2C+David%3BGladwin%2C+Mark&rft.aulast=Shiva&rft.aufirst=Sruti&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of Free Radical Metabolites by Ketones in Rats with Endotoxaemia T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40535280; 4524310 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Stadler, Krisztian AU - Jiang, JinJie AU - Augusto, Ohara AU - Kadiiska, Maria Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Ketones KW - Metabolites KW - Rats KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Generation+of+Free+Radical+Metabolites+by+Ketones+in+Rats+with+Endotoxaemia&rft.au=Stadler%2C+Krisztian%3BJiang%2C+JinJie%3BAugusto%2C+Ohara%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Enzymes and Regulatory Proteins in E. coli that are Uniquely Oxidized under Phosphate Starvation T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40535051; 4524057 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Noda, Yasuko AU - Berlett, Barbara AU - Stadtman, Earl AU - Aponte, Angel AU - Morgan, Meghan AU - Shen, Rong-Fong Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Phosphate KW - Enzymes KW - Regulatory proteins KW - Starvation KW - Escherichia coli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40535051?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Identification+of+Enzymes+and+Regulatory+Proteins+in+E.+coli+that+are+Uniquely+Oxidized+under+Phosphate+Starvation&rft.au=Noda%2C+Yasuko%3BBerlett%2C+Barbara%3BStadtman%2C+Earl%3BAponte%2C+Angel%3BMorgan%2C+Meghan%3BShen%2C+Rong-Fong&rft.aulast=Noda&rft.aufirst=Yasuko&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Copper Dependence of the Biotin Switch Assay T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40534623; 4524351 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Wang, Xunde AU - Liu, Geng AU - Macarthur, Peter AU - Hogg, Neil AU - Gladwin, Mark Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Copper KW - Biotin KW - Vitamin B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Copper+Dependence+of+the+Biotin+Switch+Assay&rft.au=Wang%2C+Xunde%3BLiu%2C+Geng%3BMacarthur%2C+Peter%3BHogg%2C+Neil%3BGladwin%2C+Mark&rft.aulast=Wang&rft.aufirst=Xunde&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deoxymyoglobin is a Nitrite Reductase that Generates NO T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40534064; 4524218 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Shiva, Sruti AU - Huang, Zhi AU - Grubina, Rozalina AU - Ringwood, Lorna AU - MacArthur, Peter AU - Gladwin, Mark Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Nitrite KW - Nitrite reductase KW - Nitric oxide KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40534064?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Deoxymyoglobin+is+a+Nitrite+Reductase+that+Generates+NO&rft.au=Shiva%2C+Sruti%3BHuang%2C+Zhi%3BGrubina%2C+Rozalina%3BRingwood%2C+Lorna%3BMacArthur%2C+Peter%3BGladwin%2C+Mark&rft.aulast=Shiva&rft.aufirst=Sruti&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The "Radical" Side of Diabetes - Unraveling a Free Radical Mechanism In Vivo and the Causative Role of iNOS T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40533088; 4524088 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Stadler, Krisztian AU - Bonini, Marcelo AU - Dallas, Shannon AU - Jiang, JinJie AU - Mason, Ronald AU - Kadiiska, Maria Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Free radicals KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533088?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=The+%22Radical%22+Side+of+Diabetes+-+Unraveling+a+Free+Radical+Mechanism+In+Vivo+and+the+Causative+Role+of+iNOS&rft.au=Stadler%2C+Krisztian%3BBonini%2C+Marcelo%3BDallas%2C+Shannon%3BJiang%2C+JinJie%3BMason%2C+Ronald%3BKadiiska%2C+Maria&rft.aulast=Stadler&rft.aufirst=Krisztian&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intravenous Ascorbic Acid as a Pro-Drug for Ascorbate Radical and H@@d2@O@@d2@ Delivery to Tissues: Implications in Cancer Treatment T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40532762; 4524005 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Chen, Qi AU - Lee, Je-Hyuk AU - Sun, Andrew AU - Zhang, Liqun AU - Espey, Michael AU - Krishna, Murali AU - Pooput, Chaya AU - Kirk, Kenneth AU - Choyke, Peter AU - Buettner, Garry AU - Shacter, Emily AU - Levine, Mark Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Cancer KW - Ascorbic acid KW - Radicals KW - Hydrogen peroxide KW - Intravenous administration KW - Vitamin C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Intravenous+Ascorbic+Acid+as+a+Pro-Drug+for+Ascorbate+Radical+and+H%40%40d2%40O%40%40d2%40+Delivery+to+Tissues%3A+Implications+in+Cancer+Treatment&rft.au=Chen%2C+Qi%3BLee%2C+Je-Hyuk%3BSun%2C+Andrew%3BZhang%2C+Liqun%3BEspey%2C+Michael%3BKrishna%2C+Murali%3BPooput%2C+Chaya%3BKirk%2C+Kenneth%3BChoyke%2C+Peter%3BBuettner%2C+Garry%3BShacter%2C+Emily%3BLevine%2C+Mark&rft.aulast=Chen&rft.aufirst=Qi&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reactions of Nitrite Ions with Cell-Free and Intra-Erythrocytic Oxyhemoglobin and the Formation of Nitrosylhemoglobin. T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40532746; 4524066 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Piknova, Barbora AU - Keszler, Agnes AU - Hogg, Neil AU - Schechter, Alan Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Ions KW - Nitrite KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Reactions+of+Nitrite+Ions+with+Cell-Free+and+Intra-Erythrocytic+Oxyhemoglobin+and+the+Formation+of+Nitrosylhemoglobin.&rft.au=Piknova%2C+Barbora%3BKeszler%2C+Agnes%3BHogg%2C+Neil%3BSchechter%2C+Alan&rft.aulast=Piknova&rft.aufirst=Barbora&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Production of Reactive Oxygen Species by Mast Cells Following FcgR Aggregation is 5-Lipoxygenase- and Cyclooxygenase-Dependent and NADPH Oxidase-Independent T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40531545; 4524158 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Swindle, Emily AU - DeLeo, Frank AU - Metcalfe, Dean Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Reactive oxygen species KW - Mast cells KW - NADPH oxidase KW - Fc receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531545?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Production+of+Reactive+Oxygen+Species+by+Mast+Cells+Following+FcgR+Aggregation+is+5-Lipoxygenase-+and+Cyclooxygenase-Dependent+and+NADPH+Oxidase-Independent&rft.au=Swindle%2C+Emily%3BDeLeo%2C+Frank%3BMetcalfe%2C+Dean&rft.aulast=Swindle&rft.aufirst=Emily&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitric Oxide Regulates MMP-9 Activity at the Protein Level T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40529916; 4524271 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Ridnour, Lisa AU - Windhausen, Alisha AU - Isenberg, Jeffery AU - Yeung, Nolan AU - Vitek, Michael AU - Roberts, David AU - Wink, David Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Nitric oxide KW - Gelatinase B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Nitric+Oxide+Regulates+MMP-9+Activity+at+the+Protein+Level&rft.au=Ridnour%2C+Lisa%3BWindhausen%2C+Alisha%3BIsenberg%2C+Jeffery%3BYeung%2C+Nolan%3BVitek%2C+Michael%3BRoberts%2C+David%3BWink%2C+David&rft.aulast=Ridnour&rft.aufirst=Lisa&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of Protein Radicals Formed in the Human Neuroglobin-H@@d2@O@@d2@ Reaction T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40529845; 4524189 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Lardinois, Olivier AU - Deterding, Leesa AU - Tomer, Kenneth AU - Mason, Ronald Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Identification+of+Protein+Radicals+Formed+in+the+Human+Neuroglobin-H%40%40d2%40O%40%40d2%40+Reaction&rft.au=Lardinois%2C+Olivier%3BDeterding%2C+Leesa%3BTomer%2C+Kenneth%3BMason%2C+Ronald&rft.aulast=Lardinois&rft.aufirst=Olivier&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nitroxyl Formation from NH@@d2@OH and NOHA Oxidation T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40529571; 4524142 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Donzelli, Sonia AU - Switzer, Christopher H AU - Espey, Michael G AU - Thomas, Douglas D AU - Ridnour, Lisa A AU - Miranda, Katrina M AU - Tocchetti, Carlo G AU - Lazzarino, Giuseppe AU - Paolocci, Nazareno AU - Wink, David A Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Oxidation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529571?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Nitroxyl+Formation+from+NH%40%40d2%40OH+and+NOHA+Oxidation&rft.au=Donzelli%2C+Sonia%3BSwitzer%2C+Christopher+H%3BEspey%2C+Michael+G%3BThomas%2C+Douglas+D%3BRidnour%2C+Lisa+A%3BMiranda%2C+Katrina+M%3BTocchetti%2C+Carlo+G%3BLazzarino%2C+Giuseppe%3BPaolocci%2C+Nazareno%3BWink%2C+David+A&rft.aulast=Donzelli&rft.aufirst=Sonia&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Susceptibility to Environmental Oxidant Lung Injury T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40528938; 4524092 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Kleeberger, Steven Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Lung KW - Oxidants KW - Injuries KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528938?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Genetic+Susceptibility+to+Environmental+Oxidant+Lung+Injury&rft.au=Kleeberger%2C+Steven&rft.aulast=Kleeberger&rft.aufirst=Steven&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Asbestos Redirects Nitric Oxide Signaling through Rapid Catalytic Conversion to Nitrite. T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40528904; 4524060 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Thomas, Douglas AU - Ridnour, Lisa AU - Espey, Michael AU - Wink, David Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Nitrite KW - Asbestos KW - Nitric oxide KW - Signal transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Asbestos+Redirects+Nitric+Oxide+Signaling+through+Rapid+Catalytic+Conversion+to+Nitrite.&rft.au=Thomas%2C+Douglas%3BRidnour%2C+Lisa%3BEspey%2C+Michael%3BWink%2C+David&rft.aulast=Thomas&rft.aufirst=Douglas&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Immunospin-Trapping Based Protein Free Radical Imaging in Sub-Cellular Structures T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40528654; 4524121 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Bonini, Marcelo AU - Mason, Ronald Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Imaging techniques KW - Free radicals KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528654?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Immunospin-Trapping+Based+Protein+Free+Radical+Imaging+in+Sub-Cellular+Structures&rft.au=Bonini%2C+Marcelo%3BMason%2C+Ronald&rft.aulast=Bonini&rft.aufirst=Marcelo&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superoxide-Dependent Hepatotoxicity of the Hsp-90 Inhibiting Anti-Cancer Drugs Geldanamycin, and its Two Derivatives T2 - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AN - 40528529; 4524107 JF - 13th Annual Meeting of the Society for Free Radical Biology and Medicine (SFRBM 2006) AU - Ishii, Hisanari AU - Hyodo, Fuminori AU - Krishna, Murali AU - Mitchell, James Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Hepatotoxicity KW - Drugs KW - Geldanamycin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528529?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.atitle=Superoxide-Dependent+Hepatotoxicity+of+the+Hsp-90+Inhibiting+Anti-Cancer+Drugs+Geldanamycin%2C+and+its+Two+Derivatives&rft.au=Ishii%2C+Hisanari%3BHyodo%2C+Fuminori%3BKrishna%2C+Murali%3BMitchell%2C+James&rft.aulast=Ishii&rft.aufirst=Hisanari&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+Annual+Meeting+of+the+Society+for+Free+Radical+Biology+and+Medicine+%28SFRBM+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://submissions.miracd.com/sfrbm2006/Itinerary/SearchResults.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering the 'O-GlcNAc Code': Lessons from C. elegans and Human Disease T2 - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AN - 40526929; 4518907 DE: JF - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AU - Hanover, John A Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40526929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.atitle=Deciphering+the+%27O-GlcNAc+Code%27%3A+Lessons+from+C.+elegans+and+Human+Disease&rft.au=Hanover%2C+John+A&rft.aulast=Hanover&rft.aufirst=John&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/default.aspx?tabid=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disruption of O-GlcNAc Cycling Mimics Diabetes Mellitus in C. elegans T2 - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AN - 40524805; 4518970 JF - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AU - Forsythe, Michele E AU - Love, Dona C AU - Kim, Eun Ju AU - Lazarus, Brooke C AU - Prinz, William AU - Ashwell, Gilbert AU - Krause, Michael W AU - Hanover, John A Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Diabetes mellitus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40524805?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.atitle=Disruption+of+O-GlcNAc+Cycling+Mimics+Diabetes+Mellitus+in+C.+elegans&rft.au=Forsythe%2C+Michele+E%3BLove%2C+Dona+C%3BKim%2C+Eun+Ju%3BLazarus%2C+Brooke+C%3BPrinz%2C+William%3BAshwell%2C+Gilbert%3BKrause%2C+Michael+W%3BHanover%2C+John+A&rft.aulast=Forsythe&rft.aufirst=Michele&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/default.aspx?tabid=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Mucin-Type O-Glycosyltransferase is Required during Multiple Stages of Drosophila Development T2 - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AN - 40524194; 4518919 JF - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AU - Tian, E AU - Hagen, Kelly G. Ten Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Developmental stages KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40524194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.atitle=A+Mucin-Type+O-Glycosyltransferase+is+Required+during+Multiple+Stages+of+Drosophila+Development&rft.au=Tian%2C+E%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Tian&rft.aufirst=E&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/default.aspx?tabid=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Functional Studies of the UDP-GalNAc:Polypeptide N-Acetylgalactosaminyltransferases in Drosophila melanogaster T2 - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AN - 40521559; 4519047 JF - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AU - Zhang, Ying AU - Hagen, Kelly G. Ten Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - N-Acetylgalactosaminyltransferase KW - Drosophila melanogaster KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.atitle=In+Vivo+Functional+Studies+of+the+UDP-GalNAc%3APolypeptide+N-Acetylgalactosaminyltransferases+in+Drosophila+melanogaster&rft.au=Zhang%2C+Ying%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Zhang&rft.aufirst=Ying&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/default.aspx?tabid=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dissecting the Biological Role of Mucin Type O-Glycosylation using RNA Interference in Drosophila Cell Culture T2 - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AN - 40521142; 4519046 JF - 2006 Annual Conference of the Society for Glycobiology (Glycobiology 2006) AU - Zhang, Liping AU - Hagen, Kelly G. Ten Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 KW - Mucins KW - Cell culture KW - RNA-mediated interference KW - Glycosylation KW - Drosophila KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40521142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.atitle=Dissecting+the+Biological+Role+of+Mucin+Type+O-Glycosylation+using+RNA+Interference+in+Drosophila+Cell+Culture&rft.au=Zhang%2C+Liping%3BHagen%2C+Kelly+G.+Ten&rft.aulast=Zhang&rft.aufirst=Liping&rft.date=2006-11-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+of+the+Society+for+Glycobiology+%28Glycobiology+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.glycobiology.org/default.aspx?tabid=108 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - First Manifestation of Multiple Myeloma as Lethal Streptococcal Sepsis TT - Fulminante Streptokokkensepsis als Erstmanifestation eines multiplen Myeloms AN - 19733907; 7581308 AB - Background: The multiple myeloma has the highest incidence among tumors of the bone and the bone marrow. Due to its rather mild and uncharacteristic clinical onset, first diagnosis of multiple myeloma is often delayed. Case Report: The case of a 60-year-old female patient is reported who had been admitted to the authors' hospital in a state of severe septicemia. The patient's medical history had been unremarkable, apart from osteoporotic complaints. Smears of both peripheral blood as well as bone marrow samples showed a massive streptococcal infestation as demonstrated by light microscopy. In addition, plasma cells were the dominant cell type in these samples allowing the diagnosis of a yet unknown full-blown multiple myeloma. Conclusion: The case suggests that in the event of indistinct bone ache, a routine serum electrophoresis is advisable to minimize the risk of missing an underlying multiple myeloma. JF - Medizinische Klinik AU - Austein, T AU - Kerstan, H AU - Aue, G AU - Schnieder, I AU - von Bloh, J AU - Badge, S AD - Medizinische Klinik, St. Bernhard Hospital, Brake, Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 SP - 905 EP - 907 VL - 101 IS - 11 SN - 0723-5003, 0723-5003 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Streptococcus KW - Electrophoresis KW - Septicemia KW - Bone marrow KW - Osteoporosis KW - Peripheral blood KW - Bone tumors KW - Infestation KW - Sepsis KW - Multiple myeloma KW - Case reports KW - Plasma cells KW - Hospitals KW - F 06915:Cancer Immunology KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19733907?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medizinische+Klinik&rft.atitle=First+Manifestation+of+Multiple+Myeloma+as+Lethal+Streptococcal+Sepsis&rft.au=Austein%2C+T%3BKerstan%2C+H%3BAue%2C+G%3BSchnieder%2C+I%3Bvon+Bloh%2C+J%3BBadge%2C+S&rft.aulast=Austein&rft.aufirst=T&rft.date=2006-11-15&rft.volume=101&rft.issue=11&rft.spage=905&rft.isbn=&rft.btitle=&rft.title=Medizinische+Klinik&rft.issn=07235003&rft_id=info:doi/10.1007%2Fs00063-006-1113-x LA - German DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Sepsis; Infestation; Bone tumors; Electrophoresis; Septicemia; Case reports; Multiple myeloma; Bone marrow; Osteoporosis; Peripheral blood; Plasma cells; Hospitals; Streptococcus DO - http://dx.doi.org/10.1007/s00063-006-1113-x ER - TY - JOUR T1 - Kinetics of mouse antibody and lymphocyte responses during intranasal vaccination with a lipooligosaccharide-based conjugate vaccine AN - 19517279; 7204730 AB - We investigated the kinetics of humoral immunity and its related cellular immune responses to intranasal (IN) immunization with a detoxified lipooligosaccharide (dLOS)-tetanus toxoid (TT) conjugate against nontypeable Haemophilus influenzae (NTHi) in mice. IN vaccination with dLOS-TT elicited high titers of LOS-specific IgA in nasal washes and IgG in sera during a course of 4 inoculations while high titers of TT-specific IgA and IgG were found in sera. A significant increase of LOS-specific IgA antibody forming cells (AFCs) was observed in nasopharyngeal-associated lymphoid tissue (NALT) and nasal passages. However, TT induced broad responses with higher numbers of IgA and IgG AFCs found in NALT and nasal passages, less but significant IgA AFCs in cervical lymphoid nodes (CLN), spleen, and lungs. Phenotypic analysis revealed a significant rise of total B220+ B-lymphocytes in NALT and CLN, particularly a rise in IgA+/IgM+ cells in the NALT after the immunization. The latter result was complied with a significant rise of IL-4 but not IFN-gamma positive CD4+ T-lymphocytes in NALT. Analysis of IgG antibody subclasses showed that an IgG1 response to both LOS and TT epitopes dominated in serum when compared to IgG2a. These kinetic antibody patterns and cellular responses may provide useful information regarding to effective mucosal vaccines against NTHi infections. JF - Immunology Letters AU - Hirano, T AU - Jiao, X AU - Chen, Z AU - Van Waes, C AU - Gu, X X AD - National Institute on Deafness and Other Communication Disorders, Rockville, MD, USA, guxx@nidcd.nih.gov Y1 - 2006/11/15/ PY - 2006 DA - 2006 Nov 15 SP - 131 EP - 139 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 107 IS - 2 SN - 0165-2478, 0165-2478 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Interleukin 4 KW - Haemophilus influenzae KW - Lymphocytes B KW - Spleen KW - Toxoids KW - Infection KW - Lymphoid tissue KW - Lipooligosaccharides KW - Immunity (humoral) KW - CD4 antigen KW - Immunoglobulin A KW - Lung KW - Kinetics KW - Lymphocytes T KW - Inoculation KW - Immunoglobulin G KW - Vaccines KW - Epitopes KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19517279?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunology+Letters&rft.atitle=Kinetics+of+mouse+antibody+and+lymphocyte+responses+during+intranasal+vaccination+with+a+lipooligosaccharide-based+conjugate+vaccine&rft.au=Hirano%2C+T%3BJiao%2C+X%3BChen%2C+Z%3BVan+Waes%2C+C%3BGu%2C+X+X&rft.aulast=Hirano&rft.aufirst=T&rft.date=2006-11-15&rft.volume=107&rft.issue=2&rft.spage=131&rft.isbn=&rft.btitle=&rft.title=Immunology+Letters&rft.issn=01652478&rft_id=info:doi/10.1016%2Fj.imlet.2006.08.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Interleukin 4; Lymphocytes B; Spleen; Toxoids; Infection; Lymphoid tissue; Lipooligosaccharides; Immunity (humoral); Immunoglobulin A; CD4 antigen; Lung; Kinetics; Immunoglobulin G; Inoculation; Lymphocytes T; Vaccines; Epitopes; Haemophilus influenzae DO - http://dx.doi.org/10.1016/j.imlet.2006.08.005 ER - TY - JOUR T1 - Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features. AN - 68151576; 17079493 AB - We have determined the crystal structure of the human base excision repair enzyme DNA polymerase beta (Pol beta) in complex with a 1-nt gapped DNA substrate containing a template N2-guanine adduct of the tumorigenic (-)-benzo[c]phenanthrene 4R,3S-diol 2S,1R-epoxide in the gap. Nucleotide insertion opposite this adduct favors incorrect purine nucleotides over the correct dCMP and hence can be mutagenic. The structure reveals that the phenanthrene ring system is stacked with the base pair immediately 3' to the modified guanine, thereby occluding the normal binding site for the correct incoming nucleoside triphosphate. The modified guanine base is displaced downstream and prevents the polymerase from achieving the catalytically competent closed conformation. The incoming nucleotide binding pocket is distorted, and the adducted deoxyguanosine is in a syn conformation, exposing its Hoogsteen edge, which can hydrogen-bond with dATP or dGTP. In a reconstituted base excision repair system, repair of a deaminated cytosine (i.e., uracil) opposite the adducted guanine was dramatically decreased at the Pol beta insertion step, but not blocked. The efficiency of gap-filling dCMP insertion opposite the adduct was diminished by >6 orders of magnitude compared with an unadducted templating guanine. In contrast, significant misinsertion of purine nucleotides (but not dTMP) opposite the adducted guanine was observed. Pol beta also misinserts a purine nucleotide opposite the adduct with ungapped DNA and exhibits limited bypass DNA synthesis. These results indicate that Pol beta-dependent base excision repair of uracil opposite, or replication through, this bulky DNA adduct can be mutagenic. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Batra, Vinod K AU - Shock, David D AU - Prasad, Rajendra AU - Beard, William A AU - Hou, Esther W AU - Pedersen, Lars C AU - Sayer, Jane M AU - Yagi, Haruhiko AU - Kumar, Subodh AU - Jerina, Donald M AU - Wilson, Samuel H AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Y1 - 2006/11/14/ PY - 2006 DA - 2006 Nov 14 SP - 17231 EP - 17236 VL - 103 IS - 46 SN - 0027-8424, 0027-8424 KW - DNA Adducts KW - 0 KW - Phenanthrenes KW - 1,2-epoxy-3,4-dihydroxy-1,2,3,4-tetrahydrobenzo(c)phenanthrene KW - 111001-48-0 KW - Uracil KW - 56HH86ZVCT KW - DNA Polymerase beta KW - EC 2.7.7.- KW - Index Medicus KW - Models, Molecular KW - Uracil -- metabolism KW - Mutation -- genetics KW - Templates, Genetic KW - Protein Structure, Tertiary KW - Nucleic Acid Conformation KW - DNA Adducts -- genetics KW - Phenanthrenes -- metabolism KW - DNA Adducts -- chemistry KW - DNA Polymerase beta -- chemistry KW - Phenanthrenes -- chemistry KW - DNA Polymerase beta -- metabolism KW - DNA Adducts -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68151576?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Structure+of+DNA+polymerase+beta+with+a+benzo%5Bc%5Dphenanthrene+diol+epoxide-adducted+template+exhibits+mutagenic+features.&rft.au=Batra%2C+Vinod+K%3BShock%2C+David+D%3BPrasad%2C+Rajendra%3BBeard%2C+William+A%3BHou%2C+Esther+W%3BPedersen%2C+Lars+C%3BSayer%2C+Jane+M%3BYagi%2C+Haruhiko%3BKumar%2C+Subodh%3BJerina%2C+Donald+M%3BWilson%2C+Samuel+H&rft.aulast=Batra&rft.aufirst=Vinod&rft.date=2006-11-14&rft.volume=103&rft.issue=46&rft.spage=17231&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - 219G; PDB N1 - SuppNotes - Cited By: Structure. 2006 Apr;14(4):757-66 [16615916] J Biol Chem. 2005 Feb 4;280(5):3764-70 [15548515] Cancer Res. 2000 Apr 1;60(7):1849-56 [10766171] Mutat Res. 2000 Apr;462(2-3):149-58 [10767626] Mutat Res. 2000 Oct;463(3):215-46 [11018743] Biochemistry. 2000 Nov 28;39(47):14603-10 [11087416] Genes Dev. 2001 Mar 1;15(5):507-21 [11238373] J Mol Biol. 2001 Mar 9;306(5):1059-80 [11237618] Biochemistry. 2001 Mar 6;40(9):2923-31 [11258904] Chem Res Toxicol. 2001 Jun;14(6):708-19 [11409942] Chem Res Toxicol. 2001 Dec;14(12):1629-42 [11743746] J Biol Chem. 2002 Apr 5;277(14):11765-71 [11821420] Biochemistry. 2002 May 14;41(19):6100-6 [11994005] Science. 2002 May 31;296(5573):1627-30 [12040171] J Mol Biol. 2002 Aug 2;321(1):29-47 [12139931] Nucleic Acids Res. 2002 Aug 1;30(15):3422-32 [12140327] J Biol Chem. 2002 Aug 23;277(34):30488-94 [12063247] Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15548-53 [12432099] Chem Res Toxicol. 2002 Dec;15(12):1619-26 [12482245] J Biol Chem. 2002 Dec 20;277(51):50046-53 [12388548] Structure. 2003 Jan;11(1):121-7 [12517346] Structure. 2003 May;11(5):489-96 [12737815] Proc Natl Acad Sci U S A. 2004 Feb 24;101(8):2265-9 [14982998] Carcinogenesis. 2004 Jun;25(6):1045-51 [14742311] Nature. 2004 Jul 15;430(6997):377-80 [15254543] J Biol Chem. 2004 Jul 23;279(30):31921-9 [15145936] Nat Struct Mol Biol. 2004 Aug;11(8):784-90 [15235589] Nature. 1977 Mar 24;266(5600):378-80 [859608] Cancer Res. 1978 Feb;38(2):354-8 [620406] Proc Natl Acad Sci U S A. 1978 Nov;75(11):5358-61 [281685] Cancer Res. 1980 Nov;40(11):3910-4 [7471042] Proc Natl Acad Sci U S A. 1981 Jan;78(1):110-4 [6165985] Cancer Res. 1984 Jun;44(6):2320-4 [6372992] Cancer Res. 1986 May;46(5):2257-61 [3697970] Nucleic Acids Res. 1990 Oct 11;18(19):5617-23 [2216754] Biochemistry. 1991 Feb 5;30(5):1342-50 [1846752] Bioessays. 1991 Feb;13(2):79-84 [2029269] Adv Exp Med Biol. 1991;283:533-53 [2069024] Proc Natl Acad Sci U S A. 1993 Feb 1;90(3):804-8 [8430089] Biochemistry. 1993 Jul 6;32(26):6523-30 [8329382] Cancer Res. 1994 Jan 1;54(1):21-4 [8261440] Biochemistry. 1995 Nov 21;34(46):15334-50 [7578150] J Biol Chem. 1996 Jun 28;271(26):15386-92 [8663082] Science. 1996 Oct 18;274(5286):430-2 [8832894] Biochemistry. 1996 Dec 24;35(51):16646-51 [8988000] Biochemistry. 1997 Sep 16;36(37):11205-15 [9287163] Mutat Res. 1998 Jun 18;402(1-2):67-75 [9675247] Carcinogenesis. 1998 Jul;19(7):1239-46 [9683183] J Biol Chem. 1998 Aug 14;273(33):21203-9 [9694877] Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12586-90 [9770529] Biochimie. 1999 Jan-Feb;81(1-2):39-44 [10214908] Mutat Res. 1999 Jul 15;443(1-2):139-47 [10415437] Chem Rev. 2006 Feb;106(2):361-82 [16464010] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Fluorescent Protein Assays using 1536-Well-Plate-Based Laser-Scanning Microplate Cytometry and qHTS T2 - 2006 Conference on Fluorescent Proteins in Drug Development AN - 40426276; 4450630 JF - 2006 Conference on Fluorescent Proteins in Drug Development AU - Auld, Doug Y1 - 2006/11/13/ PY - 2006 DA - 2006 Nov 13 KW - Cytometry KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+on+Fluorescent+Proteins+in+Drug+Development&rft.atitle=Fluorescent+Protein+Assays+using+1536-Well-Plate-Based+Laser-Scanning+Microplate+Cytometry+and+qHTS&rft.au=Auld%2C+Doug&rft.aulast=Auld&rft.aufirst=Doug&rft.date=2006-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+on+Fluorescent+Proteins+in+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2006/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Cellular MRI: Tracking Magnetically Labeled Cells in Disease Models T2 - 2006 Conference on Fluorescent Proteins in Drug Development AN - 40424662; 4450638 JF - 2006 Conference on Fluorescent Proteins in Drug Development AU - Frank, Joseph Y1 - 2006/11/13/ PY - 2006 DA - 2006 Nov 13 KW - Magnetic resonance imaging KW - Tracking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40424662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+on+Fluorescent+Proteins+in+Drug+Development&rft.atitle=In+Vivo+Cellular+MRI%3A+Tracking+Magnetically+Labeled+Cells+in+Disease+Models&rft.au=Frank%2C+Joseph&rft.aulast=Frank&rft.aufirst=Joseph&rft.date=2006-11-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+on+Fluorescent+Proteins+in+Drug+Development&rft.issn=&rft_id=info:doi/ L2 - http://www.healthtech.com/2006/gfp/index.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Generation of Additional Live Attenuated Vaccine Candidates for Dengue Virus Serotypes 1 and 3 using Reverse Genetics T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40540072; 4517785 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Blaney, Joseph AU - Sathe, Neeraj AU - Murphy, Brian AU - Whitehead, Stephen Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vaccines KW - Genetics KW - Dengue KW - Serotypes KW - Disease control KW - Dengue virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40540072?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Generation+of+Additional+Live+Attenuated+Vaccine+Candidates+for+Dengue+Virus+Serotypes+1+and+3+using+Reverse+Genetics&rft.au=Blaney%2C+Joseph%3BSathe%2C+Neeraj%3BMurphy%2C+Brian%3BWhitehead%2C+Stephen&rft.aulast=Blaney&rft.aufirst=Joseph&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct P. vivax Populations in Mexico Differentially Infect Two Local Vectors T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40539541; 4517880 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Joy, Deirdre A AU - Gonzalez-Ceron, Lilia AU - McCutchan, Thomas F AU - Sandoval, M A AU - Nettel, Jose A AU - Santillan, Frida AU - Su, Xin-zhuan Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mexico KW - Malaria KW - Vectors KW - Disease transmission KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40539541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Distinct+P.+vivax+Populations+in+Mexico+Differentially+Infect+Two+Local+Vectors&rft.au=Joy%2C+Deirdre+A%3BGonzalez-Ceron%2C+Lilia%3BMcCutchan%2C+Thomas+F%3BSandoval%2C+M+A%3BNettel%2C+Jose+A%3BSantillan%2C+Frida%3BSu%2C+Xin-zhuan&rft.aulast=Joy&rft.aufirst=Deirdre&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Microfilariae of Brugia Malayi Induce Apoptosis in Human Dendritic Cells through a TNF- And TRAIL-Dependent Mechanism and Promote the Development of Regulatory T Cells T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40538774; 4517825 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Semnani, Roshanak T AU - Goel, Priyanka AU - Kubofcik, Joseph AU - Nutman, Thomas B Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Dendritic cells KW - Apoptosis KW - Lymphocytes T KW - Immunoregulation KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40538774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Live+Microfilariae+of+Brugia+Malayi+Induce+Apoptosis+in+Human+Dendritic+Cells+through+a+TNF-+And+TRAIL-Dependent+Mechanism+and+Promote+the+Development+of+Regulatory+T+Cells&rft.au=Semnani%2C+Roshanak+T%3BGoel%2C+Priyanka%3BKubofcik%2C+Joseph%3BNutman%2C+Thomas+B&rft.aulast=Semnani&rft.aufirst=Roshanak&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase 1 Safety and Immunogenicity Trial of MSP142-FVO/Alhydrogel and MSP142-3D7/Alhydrogel Blood-Stage Malaria Vaccines in US Adults T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40536224; 4517902 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Martin, Laura B AU - Malkin, Elissa AU - Orcutt, Andrew C AU - Muratova, Olga V AU - Zhou, Hong AU - Moretz, Samuel AU - Narum, David L AU - Miles, Aaron P AU - Medina, Sarimar AU - Mahanty, Siddhartha AU - Long, Carole A AU - Miller, Louis H AU - Saul, Allan Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vaccines KW - Malaria KW - Immunogenicity KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40536224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Phase+1+Safety+and+Immunogenicity+Trial+of+MSP142-FVO%2FAlhydrogel+and+MSP142-3D7%2FAlhydrogel+Blood-Stage+Malaria+Vaccines+in+US+Adults&rft.au=Martin%2C+Laura+B%3BMalkin%2C+Elissa%3BOrcutt%2C+Andrew+C%3BMuratova%2C+Olga+V%3BZhou%2C+Hong%3BMoretz%2C+Samuel%3BNarum%2C+David+L%3BMiles%2C+Aaron+P%3BMedina%2C+Sarimar%3BMahanty%2C+Siddhartha%3BLong%2C+Carole+A%3BMiller%2C+Louis+H%3BSaul%2C+Allan&rft.aulast=Martin&rft.aufirst=Laura&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-Efficiency Gene Targeting with C57BL/6J Embryonic Stem Cells Established in a Defined Serum-Free Media T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40533871; 4522380 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Cheng, J AU - Schwartzberg, P AU - Garrett-Beal, L Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Stem cells KW - Gene targeting KW - Embryo cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533871?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=High-Efficiency+Gene+Targeting+with+C57BL%2F6J+Embryonic+Stem+Cells+Established+in+a+Defined+Serum-Free+Media&rft.au=Cheng%2C+J%3BSchwartzberg%2C+P%3BGarrett-Beal%2C+L&rft.aulast=Cheng&rft.aufirst=J&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impaired Cytoadherence of Plasmodium Falciparum- Infected Erythrocytes: Implications for the Malaria Protective Effect of Sickle Trait T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40533719; 4517800 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Cholera, Rushina AU - Fairhurst, Rick M AU - Brittain, Nathaniel J AU - Arie, Takayuki AU - Dvorak, James A AU - Wellems, Thomas E Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Malaria KW - Erythrocytes KW - Plasmodium KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40533719?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Impaired+Cytoadherence+of+Plasmodium+Falciparum-+Infected+Erythrocytes%3A+Implications+for+the+Malaria+Protective+Effect+of+Sickle+Trait&rft.au=Cholera%2C+Rushina%3BFairhurst%2C+Rick+M%3BBrittain%2C+Nathaniel+J%3BArie%2C+Takayuki%3BDvorak%2C+James+A%3BWellems%2C+Thomas+E&rft.aulast=Cholera&rft.aufirst=Rushina&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Live Microfilariae of Brugia Malayi Downregulate the Gene Expression of TLR3, 4, 5 and 7, and Diminish the Production of Cytokines in Response to a TLR3 Ligand T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40532690; 4517823 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Goel, Priyanka AU - Kubofcik, Joseph AU - Nutman, Thomas B AU - Semnani, Roshanak Tolouei Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - TLR3 protein KW - Toll-like receptors KW - Gene expression KW - Cytokines KW - Ligands KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532690?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Live+Microfilariae+of+Brugia+Malayi+Downregulate+the+Gene+Expression+of+TLR3%2C+4%2C+5+and+7%2C+and+Diminish+the+Production+of+Cytokines+in+Response+to+a+TLR3+Ligand&rft.au=Goel%2C+Priyanka%3BKubofcik%2C+Joseph%3BNutman%2C+Thomas+B%3BSemnani%2C+Roshanak+Tolouei&rft.aulast=Goel&rft.aufirst=Priyanka&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Spatio-Temporal Distribution and Ecological Determinants of Enteric Diseases in Vietnam, 1991-2001. T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40532618; 4517968 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Kelly-Hope, Louise A AU - Alonso, Wladimir J AU - Thiem, Vu Dinh AU - Anh, Dang Duc AU - Canh, Do Gia AU - Lee, Hyejon AU - Smith, David L AU - Miller, Mark A Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vietnam KW - Spatial distribution KW - Temporal variations KW - Ecological distribution KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Spatio-Temporal+Distribution+and+Ecological+Determinants+of+Enteric+Diseases+in+Vietnam%2C+1991-2001.&rft.au=Kelly-Hope%2C+Louise+A%3BAlonso%2C+Wladimir+J%3BThiem%2C+Vu+Dinh%3BAnh%2C+Dang+Duc%3BCanh%2C+Do+Gia%3BLee%2C+Hyejon%3BSmith%2C+David+L%3BMiller%2C+Mark+A&rft.aulast=Kelly-Hope&rft.aufirst=Louise&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Craniofacial and Other Skeletal Defects in Mutant Mice Reveal Shared and Gene-Specific Functions of the Three Ga@@di@ Proteins in Neural Crest and Somites T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40532194; 4522388 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Plummer, N W AU - Spicher, K AU - Birnbaumer, L Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mice KW - Mutants KW - Somites KW - Neural crest KW - Defects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=Craniofacial+and+Other+Skeletal+Defects+in+Mutant+Mice+Reveal+Shared+and+Gene-Specific+Functions+of+the+Three+Ga%40%40di%40+Proteins+in+Neural+Crest+and+Somites&rft.au=Plummer%2C+N+W%3BSpicher%2C+K%3BBirnbaumer%2C+L&rft.aulast=Plummer&rft.aufirst=N&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mammalian NURF is an Essential Component of TGFb Signaling in the Pre-Gastrulating Embryo T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40532007; 4522253 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Landry, J AU - Xiao, H AU - Southton, E AU - Tessarollo, L AU - Zhang, Y AU - Yamaguchi, T AU - Wu, C. Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Embryos KW - Signal transduction KW - Transforming growth factor-b KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40532007?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=Mammalian+NURF+is+an+Essential+Component+of+TGFb+Signaling+in+the+Pre-Gastrulating+Embryo&rft.au=Landry%2C+J%3BXiao%2C+H%3BSouthton%2C+E%3BTessarollo%2C+L%3BZhang%2C+Y%3BYamaguchi%2C+T%3BWu%2C+C.&rft.aulast=Landry&rft.aufirst=J&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Genomic Approach to Identify Cis-Acting Transcriptional Regulatory Elements T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40531825; 4522273 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Loftus, S K AU - Antonellis, A AU - Umayam, L AU - Wolfsberg, T G AU - Green, E D AU - Pavan, W J Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Regulatory sequences KW - Transcription KW - Genomics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531825?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=A+Genomic+Approach+to+Identify+Cis-Acting+Transcriptional+Regulatory+Elements&rft.au=Loftus%2C+S+K%3BAntonellis%2C+A%3BUmayam%2C+L%3BWolfsberg%2C+T+G%3BGreen%2C+E+D%3BPavan%2C+W+J&rft.aulast=Loftus&rft.aufirst=S&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allelic Variants in the Coding and Promoter Regions of Two Tumor Susceptibility Genes, p16 and mTOR, have a Compound Effect in Promoting Plasmacytoma Development T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40531655; 4522305 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Zhang, S AU - DuBois, W AU - Bliskovsky, V AU - Zhang, K AU - Robinson, R AU - Patel, J AU - Mock, B Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Promoters KW - Tumors KW - Plasmacytoma KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=Allelic+Variants+in+the+Coding+and+Promoter+Regions+of+Two+Tumor+Susceptibility+Genes%2C+p16+and+mTOR%2C+have+a+Compound+Effect+in+Promoting+Plasmacytoma+Development&rft.au=Zhang%2C+S%3BDuBois%2C+W%3BBliskovsky%2C+V%3BZhang%2C+K%3BRobinson%2C+R%3BPatel%2C+J%3BMock%2C+B&rft.aulast=Zhang&rft.aufirst=S&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Successful and Consistent Cryopreservation and Recovery of Frozen Sperm from Inbred Mouse Strains T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40531346; 4522381 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Chen, A AU - Garrett-Beal, L Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Sperm KW - Cryopreservation KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40531346?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=Successful+and+Consistent+Cryopreservation+and+Recovery+of+Frozen+Sperm+from+Inbred+Mouse+Strains&rft.au=Chen%2C+A%3BGarrett-Beal%2C+L&rft.aulast=Chen&rft.aufirst=A&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Mouse Knockout Project T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40530718; 4522265 DE: JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Fletcher, C Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40530718?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=The+Mouse+Knockout+Project&rft.au=Fletcher%2C+C&rft.aulast=Fletcher&rft.aufirst=C&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutation in Inositol 1,4,5-Triphosphate Receptor Type 1 Gene Underlies a Severe Movement Disorder in Mice T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40528579; 4522325 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - van de Leemput, J AU - Chandran, J AU - Hardy, J AU - Fisher, E AU - Cai, H AU - Singleton, A Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mutation KW - Mice KW - Movement disorders KW - Inositol 1,4,5-trisphosphate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=Mutation+in+Inositol+1%2C4%2C5-Triphosphate+Receptor+Type+1+Gene+Underlies+a+Severe+Movement+Disorder+in+Mice&rft.au=van+de+Leemput%2C+J%3BChandran%2C+J%3BHardy%2C+J%3BFisher%2C+E%3BCai%2C+H%3BSingleton%2C+A&rft.aulast=van+de+Leemput&rft.aufirst=J&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Sensitized Mouse Mutagenesis Screen for Novel Loci Regulating Mammalian Neural Crest Development T2 - 20th Annual Mammalian Genome Conference (IMGC 20) AN - 40528138; 4522292 JF - 20th Annual Mammalian Genome Conference (IMGC 20) AU - Watkins-Chow, D AU - Matera, I AU - Silver, D AU - Loftus, S K AU - Larson, D AU - Buac, K AU - Rivas, C AU - Elliot, E AU - Pavan, W J Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mutagenesis KW - Neural crest KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.atitle=A+Sensitized+Mouse+Mutagenesis+Screen+for+Novel+Loci+Regulating+Mammalian+Neural+Crest+Development&rft.au=Watkins-Chow%2C+D%3BMatera%2C+I%3BSilver%2C+D%3BLoftus%2C+S+K%3BLarson%2C+D%3BBuac%2C+K%3BRivas%2C+C%3BElliot%2C+E%3BPavan%2C+W+J&rft.aulast=Watkins-Chow&rft.aufirst=D&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+Annual+Mammalian+Genome+Conference+%28IMGC+20%29&rft.issn=&rft_id=info:doi/ L2 - http://www.imgs.org/abstracts/2006abstracts/index.shtml LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conjugating Recombinant Proteins to Pseudomonas Aeruginosa Exotoxin A: A Strategy for Significantly Enhancing Immunogenicity of Malaria Vaccine Candidates T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40523431; 4518791 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Qian, Feng AU - Wu, Yimin AU - Muratova, Olga AU - Zhou, Hong AU - Dobrescu, Gelu AU - Duggan, Peter AU - Lynn, Lambert AU - Song, Guanhong AU - Zhang, Yanling AU - Reiter, Karine AU - MacDonald, Nicholas AU - Narum, David AU - Long, Carole A AU - Saul, Allan AU - Miller, Louis AU - Mullen, Gregory E Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vaccines KW - Malaria KW - Immunogenicity KW - Exotoxin A KW - Disease control KW - Recombinants KW - Pseudomonas aeruginosa KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Conjugating+Recombinant+Proteins+to+Pseudomonas+Aeruginosa+Exotoxin+A%3A+A+Strategy+for+Significantly+Enhancing+Immunogenicity+of+Malaria+Vaccine+Candidates&rft.au=Qian%2C+Feng%3BWu%2C+Yimin%3BMuratova%2C+Olga%3BZhou%2C+Hong%3BDobrescu%2C+Gelu%3BDuggan%2C+Peter%3BLynn%2C+Lambert%3BSong%2C+Guanhong%3BZhang%2C+Yanling%3BReiter%2C+Karine%3BMacDonald%2C+Nicholas%3BNarum%2C+David%3BLong%2C+Carole+A%3BSaul%2C+Allan%3BMiller%2C+Louis%3BMullen%2C+Gregory+E&rft.aulast=Qian&rft.aufirst=Feng&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sustained High Antibody Responses Induced by Conjugation of a Poor Protein Immunogen to OMPC for Malarial Vaccine Development T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40523322; 4518780 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Wu, Yimin AU - Przysiecki, Craig AU - Flanagan, Elizabeth AU - Bello-Irizarry, Sheila N AU - Ionescu, Roxana AU - Muratova, Olga AU - Dobrescu, Gelu AU - Keister, David AU - Rippeon, Yvette AU - Long, Carole AU - Li, Shi AU - Caulfield, Michael AU - Shaw, Alan AU - Saul, Allan AU - Shiver, John AU - Miller, Louis Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vaccines KW - Antibodies KW - Conjugation KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40523322?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Sustained+High+Antibody+Responses+Induced+by+Conjugation+of+a+Poor+Protein+Immunogen+to+OMPC+for+Malarial+Vaccine+Development&rft.au=Wu%2C+Yimin%3BPrzysiecki%2C+Craig%3BFlanagan%2C+Elizabeth%3BBello-Irizarry%2C+Sheila+N%3BIonescu%2C+Roxana%3BMuratova%2C+Olga%3BDobrescu%2C+Gelu%3BKeister%2C+David%3BRippeon%2C+Yvette%3BLong%2C+Carole%3BLi%2C+Shi%3BCaulfield%2C+Michael%3BShaw%2C+Alan%3BSaul%2C+Allan%3BShiver%2C+John%3BMiller%2C+Louis&rft.aulast=Wu&rft.aufirst=Yimin&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Evaluating Trade off between Bacterial Resistance and Life History Traits of Anopheles Gambiae T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40520706; 4518729 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Lehmann, Tovi AU - DeJong, Randy AU - Diabate, Abdoulaye AU - Crawford, Jacob AU - Armbruster, Peter AU - Koebele, Carey AU - Molina-Cruz, Alvaro AU - Kumar, Sanjeev AU - Dao, Adama AU - Yaro, Alpha AU - Jaramillo-Guiterrez, Giovana AU - Adamou, Abdoulaye AU - Gupta, Lalita AU - Traore, Sekou AU - Gwadz, Robert AU - Barillas-Muray, Carolina Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Life history KW - Aquatic insects KW - Pest control KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40520706?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Evaluating+Trade+off+between+Bacterial+Resistance+and+Life+History+Traits+of+Anopheles+Gambiae&rft.au=Lehmann%2C+Tovi%3BDeJong%2C+Randy%3BDiabate%2C+Abdoulaye%3BCrawford%2C+Jacob%3BArmbruster%2C+Peter%3BKoebele%2C+Carey%3BMolina-Cruz%2C+Alvaro%3BKumar%2C+Sanjeev%3BDao%2C+Adama%3BYaro%2C+Alpha%3BJaramillo-Guiterrez%2C+Giovana%3BAdamou%2C+Abdoulaye%3BGupta%2C+Lalita%3BTraore%2C+Sekou%3BGwadz%2C+Robert%3BBarillas-Muray%2C+Carolina&rft.aulast=Lehmann&rft.aufirst=Tovi&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Evolution of Immune Genes in Members of the Anopheles Gambiae Complex T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40520650; 4518719 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Hume, Jen AU - Licht, Monica AU - Simard, Fred AU - Besansky, Nora AU - Lehmann, Tovi Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Evolutionary genetics KW - Molecular evolution KW - Aquatic insects KW - Anopheles gambiae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40520650?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Molecular+Evolution+of+Immune+Genes+in+Members+of+the+Anopheles+Gambiae+Complex&rft.au=Hume%2C+Jen%3BLicht%2C+Monica%3BSimard%2C+Fred%3BBesansky%2C+Nora%3BLehmann%2C+Tovi&rft.aulast=Hume&rft.aufirst=Jen&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Plasmodium Falciparum AMA1-C1/Alhydrogel@@u®@ + CPG 7909 Elicits Higher Antibody Titres in Mice Than Alternate Toll-Like Receptor Ligands Alone Or in Combination with CPG 7909 T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40520560; 4518501 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Rausch, Kelly M AU - Qian, Feng AU - Saul, Allan AU - Long, Carole A AU - Mullen, Gregory E Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mice KW - CpG islands KW - Antibodies KW - Toll-like receptors KW - Ligands KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40520560?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Plasmodium+Falciparum+AMA1-C1%2FAlhydrogel%40%40u%26amp%3Breg%3B%40+%2B+CPG+7909+Elicits+Higher+Antibody+Titres+in+Mice+Than+Alternate+Toll-Like+Receptor+Ligands+Alone+Or+in+Combination+with+CPG+7909&rft.au=Rausch%2C+Kelly+M%3BQian%2C+Feng%3BSaul%2C+Allan%3BLong%2C+Carole+A%3BMullen%2C+Gregory+E&rft.aulast=Rausch&rft.aufirst=Kelly&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temperature-Induced Differential Gene Expression Patterns in Third Stage Brugia Malayi Larvae T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40520252; 4518632 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Schmid, Laura J AU - Su, Qin AU - Zhu, Jack AU - Myers, Tim AU - Kubofcik, Joseph AU - Nutman, Thomas B AU - Klion, Amy D Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Larvae KW - Gene expression KW - Brugia malayi KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40520252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Temperature-Induced+Differential+Gene+Expression+Patterns+in+Third+Stage+Brugia+Malayi+Larvae&rft.au=Schmid%2C+Laura+J%3BSu%2C+Qin%3BZhu%2C+Jack%3BMyers%2C+Tim%3BKubofcik%2C+Joseph%3BNutman%2C+Thomas+B%3BKlion%2C+Amy+D&rft.aulast=Schmid&rft.aufirst=Laura&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Memory B Cell Response to AMA1-C1/Alhydrogel@@u®@ Vaccination in Malaria Naive Individuals, with Or Without the CpG Oligodeoxynucleotide Adjuvant T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40519591; 4518516 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Crompton, Peter D AU - Topham, David J AU - Mullen, Gregory E AU - Baer, Jane AU - Treanor, John AU - Miller, Louis H AU - Pierce, Susan K Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Malaria KW - Vaccination KW - Lymphocytes B KW - Memory cells KW - Oligonucleotides KW - Immunological memory KW - Adjuvants KW - CpG islands KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40519591?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=The+Memory+B+Cell+Response+to+AMA1-C1%2FAlhydrogel%40%40u%26amp%3Breg%3B%40+Vaccination+in+Malaria+Naive+Individuals%2C+with+Or+Without+the+CpG+Oligodeoxynucleotide+Adjuvant&rft.au=Crompton%2C+Peter+D%3BTopham%2C+David+J%3BMullen%2C+Gregory+E%3BBaer%2C+Jane%3BTreanor%2C+John%3BMiller%2C+Louis+H%3BPierce%2C+Susan+K&rft.aulast=Crompton&rft.aufirst=Peter&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome-Wide Gene Expression and Mechanism of Chloroquine Resistance in the Human Malaria Parasite Plasmodium Falciparum T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40519020; 4518401 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Jiang, Hongying AU - Ding, Jinhui AU - Furuya, Tetsuya AU - Mu, Jianbin AU - Cooper, Roland A AU - Su, Xinzhuan Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Parasites KW - Malaria KW - Gene expression KW - Chloroquine KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40519020?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Genome-Wide+Gene+Expression+and+Mechanism+of+Chloroquine+Resistance+in+the+Human+Malaria+Parasite+Plasmodium+Falciparum&rft.au=Jiang%2C+Hongying%3BDing%2C+Jinhui%3BFuruya%2C+Tetsuya%3BMu%2C+Jianbin%3BCooper%2C+Roland+A%3BSu%2C+Xinzhuan&rft.aulast=Jiang&rft.aufirst=Hongying&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Functional Characterization of Refolded DBL1a Domain of Plasmodium Falciparum Erthrocyte Membrane Protein-1 T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40516038; 4518655 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Zepeda, Orlando AU - Makobongo, Morris AU - Hickman, Merrit AU - MacDonald, Nicholas AU - Miller, Louis H AU - Singh, Sanjay Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Membranes KW - Plasmodium falciparum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40516038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Functional+Characterization+of+Refolded+DBL1a+Domain+of+Plasmodium+Falciparum+Erthrocyte+Membrane+Protein-1&rft.au=Zepeda%2C+Orlando%3BMakobongo%2C+Morris%3BHickman%2C+Merrit%3BMacDonald%2C+Nicholas%3BMiller%2C+Louis+H%3BSingh%2C+Sanjay&rft.aulast=Zepeda&rft.aufirst=Orlando&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parasite-Derived Lymphangiogenic Molecules: Putative Role in Mediating the Lymphatic Dysfunction Seen in Filarial Lymphedema. T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40515626; 4517738 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Bennuru, Sasisekhar AU - Nutman, Thomas B Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Molecular biology KW - Filariasis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40515626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Parasite-Derived+Lymphangiogenic+Molecules%3A+Putative+Role+in+Mediating+the+Lymphatic+Dysfunction+Seen+in+Filarial+Lymphedema.&rft.au=Bennuru%2C+Sasisekhar%3BNutman%2C+Thomas+B&rft.aulast=Bennuru&rft.aufirst=Sasisekhar&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Distinct Host Expression Signatures Induced by Closely Related Filarial Parasites T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40515599; 4517736 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Kubofcik, Joseph AU - Klimczak, Leszek J AU - Nutman, Thomas B Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Parasites KW - Hosts KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40515599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Distinct+Host+Expression+Signatures+Induced+by+Closely+Related+Filarial+Parasites&rft.au=Kubofcik%2C+Joseph%3BKlimczak%2C+Leszek+J%3BNutman%2C+Thomas+B&rft.aulast=Kubofcik&rft.aufirst=Joseph&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in the Spatial Dynamics of Seasonal Diarrhea in Mexico in 1979-2001 T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40514859; 4517590 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Alonso, Wladimir J AU - Kelly-Hope, Louise A AU - Viboud, Cecile AU - Hirano, Eduardo W AU - Miller, Mark A Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mexico KW - Seasonal variations KW - Sulfur dioxide KW - Diarrhea KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40514859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Changes+in+the+Spatial+Dynamics+of+Seasonal+Diarrhea+in+Mexico+in+1979-2001&rft.au=Alonso%2C+Wladimir+J%3BKelly-Hope%2C+Louise+A%3BViboud%2C+Cecile%3BHirano%2C+Eduardo+W%3BMiller%2C+Mark+A&rft.aulast=Alonso&rft.aufirst=Wladimir&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reversible Lymphatic Dysfunction Caused by Gnathostoma Spinigerum Infection T2 - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AN - 40512998; 4518294 JF - 55th Annual Meeting of the American Society of Tropical Medicine and Hygiene AU - Talaat, Kawsar R AU - VanHook, Robert AU - Nutman, Thomas Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Infection KW - Gnathostoma spinigerum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40512998?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.atitle=Reversible+Lymphatic+Dysfunction+Caused+by+Gnathostoma+Spinigerum+Infection&rft.au=Talaat%2C+Kawsar+R%3BVanHook%2C+Robert%3BNutman%2C+Thomas&rft.aulast=Talaat&rft.aufirst=Kawsar&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=55th+Annual+Meeting+of+the+American+Society+of+Tropical+Medicine+and+Hygiene&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B3C8365CF%2DB5A9%2D49EE% 2DA796%2D37F55F357B64%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Aortic Calpain-1 Increases with Aging, Activates Matrix Metalloproteinase II, and Promotes Vascular Smooth Muscle Cell Migration T2 - 2006 Scientific Sessions of the American Heart Association AN - 40437532; 4454721 JF - 2006 Scientific Sessions of the American Heart Association AU - Jiang, Li-Qun AU - Lakatta, Edward G Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Aging KW - Smooth muscle KW - Vascular system KW - Cell migration KW - Matrix metalloproteinase KW - Aorta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40437532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Aortic+Calpain-1+Increases+with+Aging%2C+Activates+Matrix+Metalloproteinase+II%2C+and+Promotes+Vascular+Smooth+Muscle+Cell+Migration&rft.au=Jiang%2C+Li-Qun%3BLakatta%2C+Edward+G&rft.aulast=Jiang&rft.aufirst=Li-Qun&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Transapical Aortic Valve Replacement using Real-Time Magnetic Resonance Imaging Guidance T2 - 2006 Scientific Sessions of the American Heart Association AN - 40437070; 4453603 JF - 2006 Scientific Sessions of the American Heart Association AU - Horvath, Keith AU - McVeigh, Elliot Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Magnetic resonance imaging KW - Aortic valve KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40437070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Transapical+Aortic+Valve+Replacement+using+Real-Time+Magnetic+Resonance+Imaging+Guidance&rft.au=Horvath%2C+Keith%3BMcVeigh%2C+Elliot&rft.aulast=Horvath&rft.aufirst=Keith&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Calorie Restriction Reduces MMP-2 Activity and Retards Age-associated Aortic Restructuring in Rats T2 - 2006 Scientific Sessions of the American Heart Association AN - 40435970; 4455056 JF - 2006 Scientific Sessions of the American Heart Association AU - Wang, Mingyi AU - Lakatta, Edward G Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Rats KW - Gelatinase A KW - Nutrient deficiency KW - Aorta KW - Calories KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Calorie+Restriction+Reduces+MMP-2+Activity+and+Retards+Age-associated+Aortic+Restructuring+in+Rats&rft.au=Wang%2C+Mingyi%3BLakatta%2C+Edward+G&rft.aulast=Wang&rft.aufirst=Mingyi&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Baboon CD4+ CD25+ T Regulatory Cells Inhibit Anti Porcine Xenogeneic Response T2 - 2006 Scientific Sessions of the American Heart Association AN - 40435371; 4454741 JF - 2006 Scientific Sessions of the American Heart Association AU - Mohiuddin, Muhammad M Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Lymphocytes T KW - Immunoregulation KW - CD25 antigen KW - CD4 antigen KW - Papio KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Baboon+CD4%2B+CD25%2B+T+Regulatory+Cells+Inhibit+Anti+Porcine+Xenogeneic+Response&rft.au=Mohiuddin%2C+Muhammad+M&rft.aulast=Mohiuddin&rft.aufirst=Muhammad&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Prognostic Value of Cardiac MRI in Patients Referred to Evaluate Known or Possible Coronary Artery Disease T2 - 2006 Scientific Sessions of the American Heart Association AN - 40434995; 4455167 JF - 2006 Scientific Sessions of the American Heart Association AU - Cao, Jie J AU - Arai, Andrew E Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Heart diseases KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Prognostic+Value+of+Cardiac+MRI+in+Patients+Referred+to+Evaluate+Known+or+Possible+Coronary+Artery+Disease&rft.au=Cao%2C+Jie+J%3BArai%2C+Andrew+E&rft.aulast=Cao&rft.aufirst=Jie&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High-throughput Mass Spectrometry Identifies Peptide Signature Clusters Predictive of Heart Failure Outcome: the Bucindolol Evaluation Survial Trial (BEST) Proteomic Substudy T2 - 2006 Scientific Sessions of the American Heart Association AN - 40434878; 4456873 JF - 2006 Scientific Sessions of the American Heart Association AU - Plehn, Jonathan AU - Whiteley, Gordon Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mass spectroscopy KW - Proteomics KW - Prediction KW - Peptides KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434878?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=High-throughput+Mass+Spectrometry+Identifies+Peptide+Signature+Clusters+Predictive+of+Heart+Failure+Outcome%3A+the+Bucindolol+Evaluation+Survial+Trial+%28BEST%29+Proteomic+Substudy&rft.au=Plehn%2C+Jonathan%3BWhiteley%2C+Gordon&rft.aulast=Plehn&rft.aufirst=Jonathan&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome Wide Association Study of In-stent Restenosis Identifies Multiple Candidate Susceptibility Loci T2 - 2006 Scientific Sessions of the American Heart Association AN - 40433812; 4455117 JF - 2006 Scientific Sessions of the American Heart Association AU - Ganesh, Santhi K AU - Nabel, Elizabeth G Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Genomes KW - Restenosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40433812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Genome+Wide+Association+Study+of+In-stent+Restenosis+Identifies+Multiple+Candidate+Susceptibility+Loci&rft.au=Ganesh%2C+Santhi+K%3BNabel%2C+Elizabeth+G&rft.aulast=Ganesh&rft.aufirst=Santhi&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Family History and Genetic Testing T2 - 2006 Scientific Sessions of the American Heart Association AN - 40432439; 4457381 JF - 2006 Scientific Sessions of the American Heart Association AU - O'Donnell, Christopher J Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Historical account KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40432439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Family+History+and+Genetic+Testing&rft.au=O%27Donnell%2C+Christopher+J&rft.aulast=O%27Donnell&rft.aufirst=Christopher&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Women Differ from Men in the Contribution of Vascular Progenitor Cells to Endothelial Function and Cardiovascular Risk T2 - 2006 Scientific Sessions of the American Heart Association AN - 40432426; 4456199 JF - 2006 Scientific Sessions of the American Heart Association AU - Lippincott, Margaret F AU - Cannon, Richard O Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Vascular system KW - Cardiovascular diseases KW - Stem cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40432426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Women+Differ+from+Men+in+the+Contribution+of+Vascular+Progenitor+Cells+to+Endothelial+Function+and+Cardiovascular+Risk&rft.au=Lippincott%2C+Margaret+F%3BCannon%2C+Richard+O&rft.aulast=Lippincott&rft.aufirst=Margaret&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Joint Impact of Visceral Adipose Tissue and Body Mass Index on Metabolic Risk Factors for Cardiovascular Disease: the Framingham Heart Study T2 - 2006 Scientific Sessions of the American Heart Association AN - 40432313; 4454615 JF - 2006 Scientific Sessions of the American Heart Association AU - Fox, Caroline S AU - O'Donnell, Christopher J Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Cardiovascular diseases KW - Body mass KW - Heart diseases KW - Adipose tissue KW - Body mass index KW - Risk factors KW - Joints KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40432313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=The+Joint+Impact+of+Visceral+Adipose+Tissue+and+Body+Mass+Index+on+Metabolic+Risk+Factors+for+Cardiovascular+Disease%3A+the+Framingham+Heart+Study&rft.au=Fox%2C+Caroline+S%3BO%27Donnell%2C+Christopher+J&rft.aulast=Fox&rft.aufirst=Caroline&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Socioeconomic Factors Predict the Development of the Metabolic Syndrome in Different Ethnic Groups in Mid-life Women: the Study of Women's Health Across the Nation (SWAN) T2 - 2006 Scientific Sessions of the American Heart Association AN - 40428624; 4456591 JF - 2006 Scientific Sessions of the American Heart Association AU - Scuteri, Angelo AU - Matthews, Karen A Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Socio-economic aspects KW - Ethnic groups KW - Metabolic disorders KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40428624?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Socioeconomic+Factors+Predict+the+Development+of+the+Metabolic+Syndrome+in+Different+Ethnic+Groups+in+Mid-life+Women%3A+the+Study+of+Women%27s+Health+Across+the+Nation+%28SWAN%29&rft.au=Scuteri%2C+Angelo%3BMatthews%2C+Karen+A&rft.aulast=Scuteri&rft.aufirst=Angelo&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Genetic Contribution To Heart Rate And Heart Rate Variability in Mice T2 - 2006 Scientific Sessions of the American Heart Association AN - 40426214; 4456240 JF - 2006 Scientific Sessions of the American Heart Association AU - Howden, Reuben AU - Kleeberger, Steven R Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Heart rate KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=The+Genetic+Contribution+To+Heart+Rate+And+Heart+Rate+Variability+in+Mice&rft.au=Howden%2C+Reuben%3BKleeberger%2C+Steven+R&rft.aulast=Howden&rft.aufirst=Reuben&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Echocardiographic Associations of Prevalent Stroke in an Elderly Cohort: the Age/Gene Environmental Susceptibility Reykjavik Study (AGES-Reykjavik) T2 - 2006 Scientific Sessions of the American Heart Association AN - 40425323; 4455521 JF - 2006 Scientific Sessions of the American Heart Association AU - Plehn, Jonathan F AU - Harris, Tamara Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Elderly KW - Stroke KW - Geriatrics KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Echocardiographic+Associations+of+Prevalent+Stroke+in+an+Elderly+Cohort%3A+the+Age%2FGene+Environmental+Susceptibility+Reykjavik+Study+%28AGES-Reykjavik%29&rft.au=Plehn%2C+Jonathan+F%3BHarris%2C+Tamara&rft.aulast=Plehn&rft.aufirst=Jonathan&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Prevalence of Myocardial Fibrosis and Left Ventricular Hypertrophy in Pediatric Friedreichs Ataxia: A Cardiac Magnetic Resonance Imaging Study T2 - 2006 Scientific Sessions of the American Heart Association AN - 40425300; 4454404 JF - 2006 Scientific Sessions of the American Heart Association AU - Hasbani, Keren AU - Arai, Andrew E Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Pediatrics KW - Magnetic resonance imaging KW - Friedreich's ataxia KW - Hypertrophy KW - Fibrosis KW - Heart KW - Circulatory system KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=High+Prevalence+of+Myocardial+Fibrosis+and+Left+Ventricular+Hypertrophy+in+Pediatric+Friedreichs+Ataxia%3A+A+Cardiac+Magnetic+Resonance+Imaging+Study&rft.au=Hasbani%2C+Keren%3BArai%2C+Andrew+E&rft.aulast=Hasbani&rft.aufirst=Keren&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The ApoA-I Peptide Mimetic 5A Protects Against Atherosclerosis in ApoE Deficient Mice T2 - 2006 Scientific Sessions of the American Heart Association AN - 40425216; 4455359 JF - 2006 Scientific Sessions of the American Heart Association AU - Amar, Marcelo J AU - Remaley, Alan T Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Mice KW - Arteriosclerosis KW - Apolipoprotein E KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40425216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=The+ApoA-I+Peptide+Mimetic+5A+Protects+Against+Atherosclerosis+in+ApoE+Deficient+Mice&rft.au=Amar%2C+Marcelo+J%3BRemaley%2C+Alan+T&rft.aulast=Amar&rft.aufirst=Marcelo&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Complexation of an ApoA-I Mimetic Peptide with Phospholipid Increases ABCA1-specific Cholesterol Efflux T2 - 2006 Scientific Sessions of the American Heart Association AN - 40424514; 4456353 JF - 2006 Scientific Sessions of the American Heart Association AU - Sethi, Amar A AU - Remaley, Alan T Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Cholesterol KW - Phospholipids KW - Peptides KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40424514?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Complexation+of+an+ApoA-I+Mimetic+Peptide+with+Phospholipid+Increases+ABCA1-specific+Cholesterol+Efflux&rft.au=Sethi%2C+Amar+A%3BRemaley%2C+Alan+T&rft.aulast=Sethi&rft.aufirst=Amar&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Survival in the Current Funding Environment T2 - 2006 Scientific Sessions of the American Heart Association AN - 40421551; 4457264 JF - 2006 Scientific Sessions of the American Heart Association AU - Nabel, Elizabeth G Y1 - 2006/11/12/ PY - 2006 DA - 2006 Nov 12 KW - Survival KW - Financing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40421551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.atitle=Survival+in+the+Current+Funding+Environment&rft.au=Nabel%2C+Elizabeth+G&rft.aulast=Nabel&rft.aufirst=Elizabeth&rft.date=2006-11-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Scientific+Sessions+of+the+American+Heart+Association&rft.issn=&rft_id=info:doi/ L2 - http://scientificsessions.americanheart.org/portal/scientificsessions/ ss/program LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility. AN - 68111069; 16973615 AB - The ING4 gene is a candidate tumor suppressor gene that functions in cell proliferation, contact inhibition, and angiogenesis. We identified three novel splice variants of ING4 with differing activities in controlling cell proliferation, cell spreading, and cell migration. ING4_v1 (the longest splice variant), originally identified as ING4, encodes an intact nuclear localization signal (NLS), whereas the other three splice variants (ING4_v2, ING4_v3, and ING4_v4) lack the full NLS, resulting in increased cytoplasmic localization of these proteins. We found that one of the three ING4 variants, ING4_v2, is expressed at the same level as the original ING4 (ING4_v1), suggesting that ING4 variants may have significant biological functions. Growth suppressive effects of the variants that have a partial NLS (ING4_v2 and ING4_v4) were attenuated by a weaker effect of the variants on p21(WAF1) promoter activation. ING4_v4 lost cell spreading and migration suppressive effects; on the other hand, ING4_v2 retained a cell migration suppressive effect but lost a cell spreading suppressive effect. Therefore, ING4_v2, which localized primarily into cytoplasm, might have an important role in the regulation of cell migration. We also found that ING4_v4 played dominant-negative roles in the induction of p21(WAF1) promoter activation and in the suppression of cell motility by ING4_v1. In addition, ING4 variants had different binding affinities to two cytoplasmic proteins, protein-tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha1, and G3BP2a. Understanding the functions of the four splice variants may aid in defining their roles in human carcinogenesis. JF - The Journal of biological chemistry AU - Unoki, Motoko AU - Shen, Jiang Cheng AU - Zheng, Zhi-Ming AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USa. Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 SP - 34677 EP - 34686 VL - 281 IS - 45 SN - 0021-9258, 0021-9258 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Carrier Proteins KW - Cell Cycle Proteins KW - Cyclin-Dependent Kinase Inhibitor p21 KW - DNA Primers KW - G3BP protein, human KW - Growth Inhibitors KW - Homeodomain Proteins KW - ING4 protein, human KW - NF-kappa B KW - Nuclear Localization Signals KW - PPFIA1 protein, human KW - Phosphoproteins KW - Tumor Suppressor Proteins KW - Index Medicus KW - Carrier Proteins -- metabolism KW - Fluorescent Antibody Technique, Indirect KW - Humans KW - Immunoprecipitation KW - NF-kappa B -- genetics KW - Polymerase Chain Reaction KW - Blotting, Western KW - Neoplasms -- pathology KW - Tumor Cells, Cultured KW - Polymorphism, Restriction Fragment Length KW - Cytoplasm -- metabolism KW - Cyclin-Dependent Kinase Inhibitor p21 -- metabolism KW - Molecular Sequence Data KW - Colony-Forming Units Assay KW - Phosphoproteins -- metabolism KW - Neoplasms -- metabolism KW - NF-kappa B -- metabolism KW - Growth Inhibitors -- metabolism KW - Cell Movement KW - Genetic Variation KW - Homeodomain Proteins -- genetics KW - Cell Cycle Proteins -- genetics KW - Alternative Splicing KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Homeodomain Proteins -- metabolism KW - Cell Proliferation KW - Cell Cycle Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68111069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Novel+splice+variants+of+ING4+and+their+possible+roles+in+the+regulation+of+cell+growth+and+motility.&rft.au=Unoki%2C+Motoko%3BShen%2C+Jiang+Cheng%3BZheng%2C+Zhi-Ming%3BHarris%2C+Curtis+C&rft.aulast=Unoki&rft.aufirst=Motoko&rft.date=2006-11-10&rft.volume=281&rft.issue=45&rft.spage=34677&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-21 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AB197695; GENBANK; AB197696; AB197697 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Quantitative MRI Assessment of Salivary Glands in Healthy Controls and Patients with Sjogren's Syndrome using Apparent Diffusion Coefficient (ADC) and T1 and T2 Parametric Maps T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40448734; 4459440 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Danielides, Matina AU - Kotys, Melanie AU - Leakan, Rose Anne AU - Lee, Christabel AU - Thomasson, David AU - Baker, Eva H AU - Illei, Gabor G Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Diffusion coefficients KW - Magnetic resonance imaging KW - Salivary gland KW - Maps KW - Glands KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40448734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Quantitative+MRI+Assessment+of+Salivary+Glands+in+Healthy+Controls+and+Patients+with+Sjogren%27s+Syndrome+using+Apparent+Diffusion+Coefficient+%28ADC%29+and+T1+and+T2+Parametric+Maps&rft.au=Danielides%2C+Matina%3BKotys%2C+Melanie%3BLeakan%2C+Rose+Anne%3BLee%2C+Christabel%3BThomasson%2C+David%3BBaker%2C+Eva+H%3BIllei%2C+Gabor+G&rft.aulast=Danielides&rft.aufirst=Matina&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cognitive Dysfunction and Serum Neuropeptides in Systemic Lupus Erythematosus T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40446006; 4459549 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Lapteva, Larissa AU - Yarboro, Cheryl H AU - Roebuck-Spencer, Tresa AU - Weickert, Thomas AU - Nowak, Miroslawa AU - Takada, Kazuki AU - Bleiberg, Joseph AU - Lipsky, Peter E AU - Phillips, Terry AU - Illei, Gabor G Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Systemic lupus erythematosus KW - Neuropeptides KW - Cognitive ability KW - Serum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40446006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Cognitive+Dysfunction+and+Serum+Neuropeptides+in+Systemic+Lupus+Erythematosus&rft.au=Lapteva%2C+Larissa%3BYarboro%2C+Cheryl+H%3BRoebuck-Spencer%2C+Tresa%3BWeickert%2C+Thomas%3BNowak%2C+Miroslawa%3BTakada%2C+Kazuki%3BBleiberg%2C+Joseph%3BLipsky%2C+Peter+E%3BPhillips%2C+Terry%3BIllei%2C+Gabor+G&rft.aulast=Lapteva&rft.aufirst=Larissa&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Periodic Fever, Aphthous Stomatitis, Pharyngitis and Adenitis (PFAPA) Syndrome - Clinical characterization T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40440845; 4458591 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Chitkara, Puja AU - Feder, Henry AU - Salazar, Juan AU - Barham, Beverly AU - Plass, Nicole AU - Barron, Karyl S AU - Kastner, Daniel L AU - Stojanov, Silvia Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Pharyngitis KW - Adenitis KW - Aphthous stomatitis KW - Foot-and-mouth disease KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40440845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Periodic+Fever%2C+Aphthous+Stomatitis%2C+Pharyngitis+and+Adenitis+%28PFAPA%29+Syndrome+-+Clinical+characterization&rft.au=Chitkara%2C+Puja%3BFeder%2C+Henry%3BSalazar%2C+Juan%3BBarham%2C+Beverly%3BPlass%2C+Nicole%3BBarron%2C+Karyl+S%3BKastner%2C+Daniel+L%3BStojanov%2C+Silvia&rft.aulast=Chitkara&rft.aufirst=Puja&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Tocilizumab (Humanized Anti IL-6 Receptor Monoclonal Antibody) in Patients with Systemic Lupus Erythematosus (SLE): Safety, Tolerability and Preliminary Efficacy T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40439344; 4458737 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Illei, Gabor G AU - Yarboro, Cheryl AU - Shirota, Yuko AU - Tackey, Edward AU - Lapteva, Larissa AU - Fleisher, Thomas AU - Balow, James AU - Lipsky, Peter Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Monoclonal antibodies KW - Systemic lupus erythematosus KW - Interleukin 6 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40439344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Tocilizumab+%28Humanized+Anti+IL-6+Receptor+Monoclonal+Antibody%29+in+Patients+with+Systemic+Lupus+Erythematosus+%28SLE%29%3A+Safety%2C+Tolerability+and+Preliminary+Efficacy&rft.au=Illei%2C+Gabor+G%3BYarboro%2C+Cheryl%3BShirota%2C+Yuko%3BTackey%2C+Edward%3BLapteva%2C+Larissa%3BFleisher%2C+Thomas%3BBalow%2C+James%3BLipsky%2C+Peter&rft.aulast=Illei&rft.aufirst=Gabor&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Gene Expression Analyses in Pyrin-Null Mice T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40439129; 4458020 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Stojanov, Silvia AU - Sun, Hong-Wei AU - Balow, James AU - Aksentijevich, Ivona AU - Kastner, Daniel L AU - Chae, Jae J Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Mice KW - Gene expression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40439129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Comparative+Gene+Expression+Analyses+in+Pyrin-Null+Mice&rft.au=Stojanov%2C+Silvia%3BSun%2C+Hong-Wei%3BBalow%2C+James%3BAksentijevich%2C+Ivona%3BKastner%2C+Daniel+L%3BChae%2C+Jae+J&rft.aulast=Stojanov&rft.aufirst=Silvia&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - RNA Interference of MEFV Reveals Potential Genes Regulated by Pyrin, The Familial Mediterranean Fever Protein T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40439093; 4458018 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Wood, Geryl M Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - MED KW - RNA-mediated interference KW - Fever KW - Pyrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40439093?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=RNA+Interference+of+MEFV+Reveals+Potential+Genes+Regulated+by+Pyrin%2C+The+Familial+Mediterranean+Fever+Protein&rft.au=Wood%2C+Geryl+M&rft.aulast=Wood&rft.aufirst=Geryl&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine and HLA Alleles Modulate Disease Severity in Juvenile Dermatomyositis (JDM) T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40438678; 4458179 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Mamyrova, G AU - Sillers, L AU - O'Hanlon, T AU - Pandey, J AU - Malley, J AU - Adams, S AU - James-Newton, L AU - Wallace, C AU - Sherry, D AU - Imundo, L AU - Lindsley, C AU - Madson, K AU - Perez, M AU - Miller, F AU - Rider, L Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Histocompatibility antigen HLA KW - Cytokines KW - Dermatomyositis KW - Allelles KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40438678?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Cytokine+and+HLA+Alleles+Modulate+Disease+Severity+in+Juvenile+Dermatomyositis+%28JDM%29&rft.au=Mamyrova%2C+G%3BSillers%2C+L%3BO%27Hanlon%2C+T%3BPandey%2C+J%3BMalley%2C+J%3BAdams%2C+S%3BJames-Newton%2C+L%3BWallace%2C+C%3BSherry%2C+D%3BImundo%2C+L%3BLindsley%2C+C%3BMadson%2C+K%3BPerez%2C+M%3BMiller%2C+F%3BRider%2C+L&rft.aulast=Mamyrova&rft.aufirst=G&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Epidemiology of Childhood Uveitis T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40437567; 4458516 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Smith, Janine A AU - Goldstein, Deborah AU - Mackensen, Friederike AU - Sen, Nida AU - Friedlin, Julie AU - Watkins, Angela AU - Pyatetsky, Dimitry AU - Nussenblatt, Robert AU - Tessler, Howard AU - Rosenbaum, Jim AU - Smith, Justine R Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Uveitis KW - Children KW - Epidemiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40437567?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Epidemiology+of+Childhood+Uveitis&rft.au=Smith%2C+Janine+A%3BGoldstein%2C+Deborah%3BMackensen%2C+Friederike%3BSen%2C+Nida%3BFriedlin%2C+Julie%3BWatkins%2C+Angela%3BPyatetsky%2C+Dimitry%3BNussenblatt%2C+Robert%3BTessler%2C+Howard%3BRosenbaum%2C+Jim%3BSmith%2C+Justine+R&rft.aulast=Smith&rft.aufirst=Janine&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blockade of IL-21 Inhibits B Cell Proliferation and Plasma Cell Differentiation Induced By Activated T Cells in Vitro T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40437035; 4458471 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Kuchen, Stefan AU - Robbins, Rachel AU - Sims, Gary P AU - Phillips, Terry AU - Lipsky, Peter E AU - Ettinger, Rachel Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Lymphocytes B KW - Cell proliferation KW - Interleukin 21 KW - Plasma cells KW - Differentiation KW - Lymphocytes T KW - Cell differentiation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40437035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Blockade+of+IL-21+Inhibits+B+Cell+Proliferation+and+Plasma+Cell+Differentiation+Induced+By+Activated+T+Cells+in+Vitro&rft.au=Kuchen%2C+Stefan%3BRobbins%2C+Rachel%3BSims%2C+Gary+P%3BPhillips%2C+Terry%3BLipsky%2C+Peter+E%3BEttinger%2C+Rachel&rft.aulast=Kuchen&rft.aufirst=Stefan&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Undifferentiated Periodic Fever Syndrome - a long term follow up study T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40435781; 4458586 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Chitkara, Puja AU - Jayamuni, Salini AU - Athreya, Balu H AU - Kastner, Daniel L AU - Barron, Karyl S Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Fever KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435781?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Undifferentiated+Periodic+Fever+Syndrome+-+a+long+term+follow+up+study&rft.au=Chitkara%2C+Puja%3BJayamuni%2C+Salini%3BAthreya%2C+Balu+H%3BKastner%2C+Daniel+L%3BBarron%2C+Karyl+S&rft.aulast=Chitkara&rft.aufirst=Puja&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Modifiers of SLE and Btk-Dependent Anti-RNA B Cells in Yaa Mice due to Tlr7 Gene Duplication T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40435761; 4458562 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Pisitkun, Prapaporn AU - Deane, Jonathan A AU - Difilippantonio, Michael J AU - Tarasenko, Tatyana AU - Satterthwaite, Anne B AU - Bolland, Silvia Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Mice KW - Lymphocytes B KW - Gene duplication KW - Toll-like receptors KW - TLR7 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Genetic+Modifiers+of+SLE+and+Btk-Dependent+Anti-RNA+B+Cells+in+Yaa+Mice+due+to+Tlr7+Gene+Duplication&rft.au=Pisitkun%2C+Prapaporn%3BDeane%2C+Jonathan+A%3BDifilippantonio%2C+Michael+J%3BTarasenko%2C+Tatyana%3BSatterthwaite%2C+Anne+B%3BBolland%2C+Silvia&rft.aulast=Pisitkun&rft.aufirst=Prapaporn&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imbalance between Pro- and Anti-Inflammatory Roles of TGF-b in Sjogrens Syndrome T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40435227; 4457517 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Katsifis, G E AU - Rekka, S A AU - Moutsopoulos, N M AU - Kapsogeorgou, E K AU - Moutsopoulos, H M AU - Wahl, S M Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Transforming growth factor-b KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40435227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Imbalance+between+Pro-+and+Anti-Inflammatory+Roles+of+TGF-b+in+Sjogrens+Syndrome&rft.au=Katsifis%2C+G+E%3BRekka%2C+S+A%3BMoutsopoulos%2C+N+M%3BKapsogeorgou%2C+E+K%3BMoutsopoulos%2C+H+M%3BWahl%2C+S+M&rft.aulast=Katsifis&rft.aufirst=G&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Immune Depletion Following Novel Lymphoablative Regimen for Autologous Hematopoietic Stem Cell Transplantation (AutoHSCT) in Systemic Lupus Erythematosus (SLE) T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40434740; 4457686 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Nikolov, Nikolay P AU - Illei, Gabor G AU - Yarboro, Cheryl AU - Hakim, Frances AU - Leitman, Susan AU - Read, Elizabeth AU - Khuu, Hanh AU - Grammer, Amrie AU - Fischer, Randy AU - Balow, James AU - Austin, Howard AU - Gea-Banacloche, Juan AU - Muraro, Paolo AU - Babb, Rebecca AU - Krumlauf, Michael AU - Sportes, Claude AU - Lipsky, Peter AU - Gress, Ronald AU - Pavletic, Steven Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Stem cells KW - Systemic lupus erythematosus KW - Autografts KW - Transplantation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434740?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Effective+Immune+Depletion+Following+Novel+Lymphoablative+Regimen+for+Autologous+Hematopoietic+Stem+Cell+Transplantation+%28AutoHSCT%29+in+Systemic+Lupus+Erythematosus+%28SLE%29&rft.au=Nikolov%2C+Nikolay+P%3BIllei%2C+Gabor+G%3BYarboro%2C+Cheryl%3BHakim%2C+Frances%3BLeitman%2C+Susan%3BRead%2C+Elizabeth%3BKhuu%2C+Hanh%3BGrammer%2C+Amrie%3BFischer%2C+Randy%3BBalow%2C+James%3BAustin%2C+Howard%3BGea-Banacloche%2C+Juan%3BMuraro%2C+Paolo%3BBabb%2C+Rebecca%3BKrumlauf%2C+Michael%3BSportes%2C+Claude%3BLipsky%2C+Peter%3BGress%2C+Ronald%3BPavletic%2C+Steven&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Autoimmunity and Impaired T Cell Apoptosis in Wiskott-Aldrich Syndrome Protein Deficiency: A FasL Connection T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40434656; 4458335 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Nikolov, Nikolay P AU - Bailey, Daniel AU - Candotti, Fabio AU - Schwartzberg, Pamela L AU - Strom, Ted AU - Siegel, Richard M Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - FasL protein KW - Protein deficiency KW - Apoptosis KW - Wiskott-Aldrich syndrome KW - Lymphocytes T KW - Autoimmunity KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40434656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Autoimmunity+and+Impaired+T+Cell+Apoptosis+in+Wiskott-Aldrich+Syndrome+Protein+Deficiency%3A+A+FasL+Connection&rft.au=Nikolov%2C+Nikolay+P%3BBailey%2C+Daniel%3BCandotti%2C+Fabio%3BSchwartzberg%2C+Pamela+L%3BStrom%2C+Ted%3BSiegel%2C+Richard+M&rft.aulast=Nikolov&rft.aufirst=Nikolay&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Density SNP-Typing Identifies Two Regions on Chromosome 18q that are Associated with Susceptibility to Rheumatoid Arthritis T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40433326; 4458910 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Remmers, Elaine F AU - Le, Julie M AU - Li, Wentian AU - Lee, Annette T AU - Chen, Wei AU - Seldin, Michael F AU - Criswell, Lindsey A AU - Amos, Christopher I AU - Gregersen, Peter K AU - Kastner, Daniel L Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Chromosomes KW - Chromosome 18 KW - Rheumatoid arthritis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40433326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=High+Density+SNP-Typing+Identifies+Two+Regions+on+Chromosome+18q+that+are+Associated+with+Susceptibility+to+Rheumatoid+Arthritis&rft.au=Remmers%2C+Elaine+F%3BLe%2C+Julie+M%3BLi%2C+Wentian%3BLee%2C+Annette+T%3BChen%2C+Wei%3BSeldin%2C+Michael+F%3BCriswell%2C+Lindsey+A%3BAmos%2C+Christopher+I%3BGregersen%2C+Peter+K%3BKastner%2C+Daniel+L&rft.aulast=Remmers&rft.aufirst=Elaine&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Successful Anti-TNF Therapy Improves the Suppressor Function of CD4+CD25hi T Regulatory Cells in RA T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40432687; 4457493 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Valencia, Xavier AU - Simone, James AU - Goldbach-Mansky, Raphaela AU - Wilson, Mildred AU - Lipsky, Peter Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Lymphocytes T KW - Immunoregulation KW - Suppressors KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40432687?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Successful+Anti-TNF+Therapy+Improves+the+Suppressor+Function+of+CD4%2BCD25hi+T+Regulatory+Cells+in+RA&rft.au=Valencia%2C+Xavier%3BSimone%2C+James%3BGoldbach-Mansky%2C+Raphaela%3BWilson%2C+Mildred%3BLipsky%2C+Peter&rft.aulast=Valencia&rft.aufirst=Xavier&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Analysis of the Pyrin B30.2 Domain and its Interaction with Caspase-1 - the Consequences of FMF Mutations T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40430550; 4457634 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Masters, Seth L AU - Chae, Jae Jin AU - Yao, Shenggen AU - Nicola, Nicos A AU - Norton, Raymond S AU - Nicholson, Sandra E AU - Smith, Brian J AU - Kastner, Daniel L Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Mutation KW - Structural analysis KW - Caspase-1 KW - Pyrin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430550?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Structural+Analysis+of+the+Pyrin+B30.2+Domain+and+its+Interaction+with+Caspase-1+-+the+Consequences+of+FMF+Mutations&rft.au=Masters%2C+Seth+L%3BChae%2C+Jae+Jin%3BYao%2C+Shenggen%3BNicola%2C+Nicos+A%3BNorton%2C+Raymond+S%3BNicholson%2C+Sandra+E%3BSmith%2C+Brian+J%3BKastner%2C+Daniel+L&rft.aulast=Masters&rft.aufirst=Seth&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - TNFSF5/CD154/CD40L Engagement on Activated B Cells from SLE Periphery or the Tonsil Induces Proximal Signaling Events and Differentiation to Plasma Cells T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40430536; 4457824 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Fiorini, Claudia AU - Lougaris, Vassilios AU - Lugar, Patricia L AU - Slota, Rebecca AU - van der Zouwen, Boris AU - Melchers, Mark AU - Withers, David R AU - Fischer, Randy T AU - Phillips, Terry AU - Plebani, Alessandro AU - Lipsky, Peter E AU - Amrie, C Grammer Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Signal transduction KW - Lymphocytes B KW - Plasma cells KW - Differentiation KW - CD154 antigen KW - Tonsil KW - CD40L protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40430536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=TNFSF5%2FCD154%2FCD40L+Engagement+on+Activated+B+Cells+from+SLE+Periphery+or+the+Tonsil+Induces+Proximal+Signaling+Events+and+Differentiation+to+Plasma+Cells&rft.au=Fiorini%2C+Claudia%3BLougaris%2C+Vassilios%3BLugar%2C+Patricia+L%3BSlota%2C+Rebecca%3Bvan+der+Zouwen%2C+Boris%3BMelchers%2C+Mark%3BWithers%2C+David+R%3BFischer%2C+Randy+T%3BPhillips%2C+Terry%3BPlebani%2C+Alessandro%3BLipsky%2C+Peter+E%3BAmrie%2C+C+Grammer&rft.aulast=Fiorini&rft.aufirst=Claudia&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Familial Mediterranean Fever Protein, Pyrin, Modulates Il-1ss Production by C-terminal Interaction With Caspase-1, and Activates Nf-?B Through its N-terminal Cleaved Fragment T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40429994; 4459794 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Chae, Jae Jin AU - Wood, Geryl AU - Richard, Katharina AU - Masters, Seth AU - Jaffe, Howard AU - Colburn, Nona AU - Gumucio, Deborah L AU - Shoham, Nitza G AU - Kastner, Daniel L Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - MED KW - Caspase-1 KW - Pyrin KW - Fever KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40429994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=The+Familial+Mediterranean+Fever+Protein%2C+Pyrin%2C+Modulates+Il-1ss+Production+by+C-terminal+Interaction+With+Caspase-1%2C+and+Activates+Nf-%3FB+Through+its+N-terminal+Cleaved+Fragment&rft.au=Chae%2C+Jae+Jin%3BWood%2C+Geryl%3BRichard%2C+Katharina%3BMasters%2C+Seth%3BJaffe%2C+Howard%3BColburn%2C+Nona%3BGumucio%2C+Deborah+L%3BShoham%2C+Nitza+G%3BKastner%2C+Daniel+L&rft.aulast=Chae&rft.aufirst=Jae&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Race is a Risk Factor for ECG Abnormalities in Polymyositis (PM)/Dermatomyositis (DM) T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40429492; 4458094 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Gourley, Mark F AU - Diamond, Shari B AU - Rosing, Douglas AU - Naeem, Mehmooda AU - James-Newton, Laura AU - Miller, Frederick Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Polymyositis KW - EKG KW - Races KW - Dermatomyositis KW - Risk factors KW - Abnormalities KW - Subpopulations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40429492?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Race+is+a+Risk+Factor+for+ECG+Abnormalities+in+Polymyositis+%28PM%29%2FDermatomyositis+%28DM%29&rft.au=Gourley%2C+Mark+F%3BDiamond%2C+Shari+B%3BRosing%2C+Douglas%3BNaeem%2C+Mehmooda%3BJames-Newton%2C+Laura%3BMiller%2C+Frederick&rft.aulast=Gourley&rft.aufirst=Mark&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Chinese Shar-Pei Dog is a Natural Model of Human Autoinflammatory Diseases: Screening for Mutations in the Canine Mefv, Tnfrsf1a, Cias1 and Mvk. T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40429293; 4459796 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Puppo, Francesca AU - Tintle, Linda AU - Wong, Austin AU - Aksentijevich, Ivona AU - Avery, Anne AU - Remmers, Elaine AU - Kastner, Daniel Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Mutation KW - Models KW - Screening KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40429293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=The+Chinese+Shar-Pei+Dog+is+a+Natural+Model+of+Human+Autoinflammatory+Diseases%3A+Screening+for+Mutations+in+the+Canine+Mefv%2C+Tnfrsf1a%2C+Cias1+and+Mvk.&rft.au=Puppo%2C+Francesca%3BTintle%2C+Linda%3BWong%2C+Austin%3BAksentijevich%2C+Ivona%3BAvery%2C+Anne%3BRemmers%2C+Elaine%3BKastner%2C+Daniel&rft.aulast=Puppo&rft.aufirst=Francesca&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Studies In Neonatal-Onset Multisystem Inflammatory Disease (NOMID) Patients Broaden the Role of Cias1 in the Regulation of Inflammation T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40428604; 4459795 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Aksentijevich, Ivona AU - Balow Jr, James AU - Dozmorov, Igor AU - Sun, Hong-Wei AU - Jones, Janet AU - Dailey, Natalie AU - Canna, Scott AU - Goldbach-Mansky, Raphaela AU - Kastner, Daniel L Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Gene expression KW - Inflammatory diseases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40428604?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=Gene+Expression+Studies+In+Neonatal-Onset+Multisystem+Inflammatory+Disease+%28NOMID%29+Patients+Broaden+the+Role+of+Cias1+in+the+Regulation+of+Inflammation&rft.au=Aksentijevich%2C+Ivona%3BBalow+Jr%2C+James%3BDozmorov%2C+Igor%3BSun%2C+Hong-Wei%3BJones%2C+Janet%3BDailey%2C+Natalie%3BCanna%2C+Scott%3BGoldbach-Mansky%2C+Raphaela%3BKastner%2C+Daniel+L&rft.aulast=Aksentijevich&rft.aufirst=Ivona&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Relationship between Subchondral Bone and Bone Mineral Density in a Non-Human Primate Model of Osteoarthritis T2 - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AN - 40422892; 4457619 JF - 70th Annual Meeting of the American College of Rheumatology and the 41st Annual Meeting of the Association of Rheumatology Health Professionals (ACR/ARHP 2006) AU - Blair-Levy, Joy M AU - Watts, Christopher E AU - Fiorentino, Niccolo M AU - Wylie, James AU - Lipsky, Peter E Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 KW - Bone mineral density KW - Bone (subchondral) KW - Primates KW - Osteoarthritis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40422892?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.atitle=The+Relationship+between+Subchondral+Bone+and+Bone+Mineral+Density+in+a+Non-Human+Primate+Model+of+Osteoarthritis&rft.au=Blair-Levy%2C+Joy+M%3BWatts%2C+Christopher+E%3BFiorentino%2C+Niccolo+M%3BWylie%2C+James%3BLipsky%2C+Peter+E&rft.aulast=Blair-Levy&rft.aufirst=Joy&rft.date=2006-11-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=70th+Annual+Meeting+of+the+American+College+of+Rheumatology+and+the+41st+Annual+Meeting+of+the+Association+of+Rheumatology+Health+Professionals+%28ACR%2FARHP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7BC297FA F7%2D2B4C%2D45F5%2DA662%2D0972E559ED7D%7D&AKey=%7BAA45DD66%2DF113%2D 4CDD%2D8E62%2D01A05F613C0D%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Mutational Analysis of sigma super(7) super(0) Region 4 Needed for Appropriation by the Bacteriophage T4 Transcription Factors AsiA and MotA AN - 19774161; 7147562 AB - Transcriptional activation of bacteriophage T4 middle promoters requires sigma super(7) super(0)-containing Escherichia coli RNA polymerase, the T4 activator MotA, and the T4 co-activator AsiA. T4 middle promoters contain the sigma super(7) super(0) -10 DNA element. However, these promoters lack the sigma super(7) super(0) -35 element, having instead a MotA box centered at -30, which is bound by MotA. Previous work has indicated that AsiA and MotA interact with region 4 of sigma super(7) super(0), the C-terminal portion that normally contacts -35 DNA and the beta -flap structure in core. AsiA binding prevents the sigma super(7) super(0) / beta -flap and sigma super(7) super(0)/-35 DNA interactions, inhibiting transcription from promoters that require a -35 element. To test the importance of residues within sigma super(7) super(0) region 4 for MotA and AsiA function, we investigated how sigma super(7) super(0) region 4 mutants interact with AsiA, MotA, and the beta -flap and function in transcription assays in vitro. We find that alanine substitutions at residues 584-588 (region 4.2) do not impair the interaction of region 4 with the beta -flap or MotA, but they eliminate the interaction with AsiA and prevent AsiA inhibition and MotA/AsiA activation. In contrast, alanine substitutions at 551-552, 554-555 (region 4.1) eliminate the region 4/ beta -flap interaction, significantly impair the AsiA / sigma super(7) super(0) interaction, and eliminate AsiA inhibition. However, the 4.1 mutant sigma super(7) super(0) is still fully competent for activation if both MotA and AsiA are present. A previous NMR structure shows AsiA binding to sigma super(7) super(0) region 4, dramatically distorting regions 4.1 and 4.2 and indirectly changing the conformation of the MotA interaction site at the sigma super(7) super(0) C terminus. Our analyses provide biochemical relevance for the sigma super(7) super(0) residues identified in the structure, indicate that the interaction of AsiA with sigma super(7) super(0) region 4.2 is crucial for activation, and support the idea that AsiA binding facilitates an interaction between MotA and the far C terminus of sigma super(7) super(0). JF - Journal of Molecular Biology AU - Baxter, K AU - Lee, J AU - Minakhin, L AU - Severinov, K AU - Hinton, D M AD - Laboratory of Molecular and Cellular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-0830, USA, dhinton@helix.nih.gov Y1 - 2006/11/10/ PY - 2006 DA - 2006 Nov 10 SP - 931 EP - 944 VL - 363 IS - 5 SN - 0022-2836, 0022-2836 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Promoters KW - DNA-directed RNA polymerase KW - Alanine KW - Transcription factors KW - Escherichia coli KW - DNA KW - N.M.R. KW - Transcription activation KW - Conformation KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19774161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Biology&rft.atitle=Mutational+Analysis+of+sigma+super%287%29+super%280%29+Region+4+Needed+for+Appropriation+by+the+Bacteriophage+T4+Transcription+Factors+AsiA+and+MotA&rft.au=Baxter%2C+K%3BLee%2C+J%3BMinakhin%2C+L%3BSeverinov%2C+K%3BHinton%2C+D+M&rft.aulast=Baxter&rft.aufirst=K&rft.date=2006-11-10&rft.volume=363&rft.issue=5&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Biology&rft.issn=00222836&rft_id=info:doi/10.1016%2Fj.jmb.2006.08.074 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Promoters; DNA-directed RNA polymerase; Alanine; Transcription factors; DNA; N.M.R.; Transcription activation; Conformation; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmb.2006.08.074 ER - TY - JOUR T1 - Compartmentalized Ca(2+) channel regulation at divergent mossy-fiber release sites underlies target cell-dependent plasticity. AN - 68136297; 17088215 AB - Hippocampal mossy fibers (MFs) innervate CA3 targets via anatomically distinct presynaptic elements: MF boutons (MFBs) innervate pyramidal cells (PYRs), whereas filopodial extensions (Fils) of MFBs innervate st. lucidum interneurons (SLINs). Surprisingly, the same high-frequency stimulation (HFS) protocol induces presynaptically expressed LTP and LTD at PYR and SLIN inputs, respectively. This differential distribution of plasticity indicates that neighboring, functionally divergent presynaptic elements along the same axon serve as autonomous computational elements capable of modifying release independently. Indeed we report that HFS persistently depresses voltage-gated calcium channel (VGCC) function in Fil terminals, leaving MFB VGCCs unchanged despite similar contributions of N- and P/Q-type VGCCs to transmission at each terminal. Selective Fil VGCC depression results from HFS-induced mGluR7 activation leading to persistent P/Q-type VGCC inhibition. Thus, mGluR7 localization to MF-SLIN terminals and not MFBs allows for MF-SLIN LTD expression via depressed presynaptic VGCC function, whereas MF-PYR plasticity proceeds independently of VGCC alterations. JF - Neuron AU - Pelkey, Kenneth A AU - Topolnik, Lisa AU - Lacaille, Jean-Claude AU - McBain, Chris J AD - Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Building 35, Bethesda, Maryland 20892, USA. pelkeyk2@mail.nih.gov Y1 - 2006/11/09/ PY - 2006 DA - 2006 Nov 09 SP - 497 EP - 510 VL - 52 IS - 3 SN - 0896-6273, 0896-6273 KW - 2-amino-4-phosphono-propinate KW - 0 KW - Calcium Channel Blockers KW - Calcium Channels KW - Cyclopropanes KW - Propionates KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor 3 KW - 2-(2,3-dicarboxycyclopropyl)glycine KW - 147782-19-2 KW - Calcium KW - SY7Q814VUP KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Presynaptic Terminals -- radiation effects KW - Glycine -- analogs & derivatives KW - Receptors, Metabotropic Glutamate -- physiology KW - Presynaptic Terminals -- drug effects KW - Excitatory Postsynaptic Potentials -- drug effects KW - Calcium Channel Blockers -- pharmacology KW - Glycine -- pharmacology KW - Excitatory Postsynaptic Potentials -- radiation effects KW - In Vitro Techniques KW - Presynaptic Terminals -- physiology KW - Excitatory Postsynaptic Potentials -- physiology KW - Patch-Clamp Techniques -- methods KW - Synaptic Transmission -- radiation effects KW - Synaptic Transmission -- drug effects KW - Propionates -- pharmacology KW - Cyclopropanes -- pharmacology KW - Mice KW - Synaptic Transmission -- physiology KW - Dose-Response Relationship, Radiation KW - Neural Inhibition -- physiology KW - Hippocampus -- cytology KW - Mice, Inbred C57BL KW - Mossy Fibers, Hippocampal -- physiology KW - Calcium Channels -- metabolism KW - Neurons -- cytology KW - Neurons -- physiology KW - Neuronal Plasticity -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68136297?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Compartmentalized+Ca%282%2B%29+channel+regulation+at+divergent+mossy-fiber+release+sites+underlies+target+cell-dependent+plasticity.&rft.au=Pelkey%2C+Kenneth+A%3BTopolnik%2C+Lisa%3BLacaille%2C+Jean-Claude%3BMcBain%2C+Chris+J&rft.aulast=Pelkey&rft.aufirst=Kenneth&rft.date=2006-11-09&rft.volume=52&rft.issue=3&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - GABAergic input onto CA3 hippocampal interneurons remains shunting throughout development. AN - 68126698; 17093093 AB - In hippocampus, the net flow of excitability is controlled by inhibitory input provided by the many populations of local circuit inhibitory interneurons. In principal cells, GABA(A) receptor-mediated synaptic input undergoes a highly coordinated shift from depolarizing early in life to a more conventional hyperpolarizing inhibition on maturation. This switch in inhibitory input polarity is controlled by the developmental regulation of two chloride cotransporters (NKCC1 and KCC2) that results in a net shift from high to low intracellular Cl(-). Whether inhibitory input onto inhibitory interneurons demonstrates a similar developmental shift in intracellular Cl(-) is unexplored. Using the gramicidin perforated-patch configuration, we recorded from CA3 hippocampal stratum lucidum interneurons and pyramidal cells to monitor inhibitory input across a broad developmental range. GABA(A) receptor-mediated synaptic input onto stratum lucidum inhibitory interneurons was shunting in nature across the entire developmental age range tested, as resting membrane potential and the IPSC reversal potential remained within a few millivolts (1-4 mV) between postnatal day 5 (P5) and P31. Furthermore, sensitivity to block of the two chloride cotransporters KCC2 and NKCC1 did not differ across the same age range, suggesting that their relative expression is fixed across development. In contrast, pyramidal cell synaptic inhibition demonstrated the well described switch from depolarizing to hyperpolarizing over the same age range. Thus, in contrast to principal cells, inhibitory synaptic input onto CA3 interneurons remains shunting throughout development. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Banke, Tue G AU - McBain, Chris J AD - Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/11/08/ PY - 2006 DA - 2006 Nov 08 SP - 11720 EP - 11725 VL - 26 IS - 45 KW - GABA Antagonists KW - 0 KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - biocytin KW - G6D6147J22 KW - Lysine KW - K3Z4F929H6 KW - Bicuculline KW - Y37615DVKC KW - Index Medicus KW - Patch-Clamp Techniques -- methods KW - Bicuculline -- pharmacology KW - Animals KW - Age Factors KW - Electric Stimulation -- methods KW - Mice KW - Dose-Response Relationship, Radiation KW - GABA Antagonists -- pharmacology KW - Inhibitory Postsynaptic Potentials -- drug effects KW - Inhibitory Postsynaptic Potentials -- physiology KW - Lysine -- metabolism KW - Inhibitory Postsynaptic Potentials -- radiation effects KW - Animals, Newborn KW - In Vitro Techniques KW - Lysine -- analogs & derivatives KW - Interneurons -- radiation effects KW - Synaptic Transmission -- radiation effects KW - Neural Inhibition -- radiation effects KW - Synapses -- drug effects KW - Synaptic Transmission -- drug effects KW - Synapses -- radiation effects KW - Neural Inhibition -- drug effects KW - Synaptic Transmission -- physiology KW - Neural Inhibition -- physiology KW - Synapses -- physiology KW - Hippocampus -- growth & development KW - Interneurons -- drug effects KW - Hippocampus -- cytology KW - Interneurons -- cytology KW - Interneurons -- physiology KW - gamma-Aminobutyric Acid -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68126698?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=GABAergic+input+onto+CA3+hippocampal+interneurons+remains+shunting+throughout+development.&rft.au=Banke%2C+Tue+G%3BMcBain%2C+Chris+J&rft.aulast=Banke&rft.aufirst=Tue&rft.date=2006-11-08&rft.volume=26&rft.issue=45&rft.spage=11720&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-11-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. AN - 68126411; 17093100 AB - Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease is caused by a selective loss of motor neurons. One form of juvenile onset autosomal recessive ALS (ALS2) has been linked to the loss of function of the ALS2 gene. The pathogenic mechanism of ALS2-deficiency, however, remains unclear. To further understand the function of alsin that is encoded by the full-length ALS2 gene, we screened proteins interacting with alsin. Here, we report that alsin interacted with glutamate receptor interacting protein 1 (GRIP1) both in vitro and in vivo, and colocalized with GRIP1 in neurons. In support of the physiological interaction between alsin and GRIP1, the subcellular distribution of GRIP1 was altered in ALS2(-/-) spinal motor neurons, which correlates with a significant reduction of AMPA-type glutamate receptor subunit 2 (GluR2) at the synaptic/cell surface of ALS2(-/-) neurons. The decrease of calcium-impermeable GluR2-containing AMPA receptors at the cell/synaptic surface rendered ALS2(-/-) neurons more susceptible to glutamate receptor-mediated neurotoxicity. Our findings reveal a novel function of alsin in AMPA receptor trafficking and provide a novel pathogenic link between ALS2-deficiency and motor neuron degeneration, suggesting a protective role of alsin in maintaining the survival of motor neurons. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Lai, Chen AU - Xie, Chengsong AU - McCormack, Stefanie G AU - Chiang, Hsueh-Cheng AU - Michalak, Marta K AU - Lin, Xian AU - Chandran, Jayanth AU - Shim, Hoon AU - Shimoji, Mika AU - Cookson, Mark R AU - Huganir, Richard L AU - Rothstein, Jeffrey D AU - Price, Donald L AU - Wong, Philip C AU - Martin, Lee J AU - Zhu, J Julius AU - Cai, Huaibin AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892-3707, USA. Y1 - 2006/11/08/ PY - 2006 DA - 2006 Nov 08 SP - 11798 EP - 11806 VL - 26 IS - 45 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Als2 protein, mouse KW - Excitatory Amino Acid Agonists KW - Grip1 protein, mouse KW - Guanine Nucleotide Exchange Factors KW - Nerve Tissue Proteins KW - Receptors, AMPA KW - glutamate receptor ionotropic, AMPA 2 KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - Index Medicus KW - Animals KW - Cerebral Cortex -- cytology KW - Protein Transport -- drug effects KW - Neurons -- drug effects KW - Humans KW - Disease Models, Animal KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - Mice KW - Cell Membrane -- physiology KW - Mice, Knockout KW - Subcellular Fractions -- drug effects KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Transfection -- methods KW - Cell Survival -- drug effects KW - Biotinylation -- methods KW - In Vitro Techniques KW - Neurons -- physiology KW - Nerve Tissue Proteins -- metabolism KW - Excitatory Amino Acid Agonists -- pharmacology KW - Immunoprecipitation -- methods KW - Subcellular Fractions -- metabolism KW - Cell Line KW - Spinal Cord -- cytology KW - Guanine Nucleotide Exchange Factors -- deficiency KW - Amyotrophic Lateral Sclerosis -- metabolism KW - Receptors, AMPA -- metabolism KW - Guanine Nucleotide Exchange Factors -- genetics KW - Amyotrophic Lateral Sclerosis -- complications KW - Nerve Degeneration -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68126411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Amyotrophic+lateral+sclerosis+2-deficiency+leads+to+neuronal+degeneration+in+amyotrophic+lateral+sclerosis+through+altered+AMPA+receptor+trafficking.&rft.au=Lai%2C+Chen%3BXie%2C+Chengsong%3BMcCormack%2C+Stefanie+G%3BChiang%2C+Hsueh-Cheng%3BMichalak%2C+Marta+K%3BLin%2C+Xian%3BChandran%2C+Jayanth%3BShim%2C+Hoon%3BShimoji%2C+Mika%3BCookson%2C+Mark+R%3BHuganir%2C+Richard+L%3BRothstein%2C+Jeffrey+D%3BPrice%2C+Donald+L%3BWong%2C+Philip+C%3BMartin%2C+Lee+J%3BZhu%2C+J+Julius%3BCai%2C+Huaibin&rft.aulast=Lai&rft.aufirst=Chen&rft.date=2006-11-08&rft.volume=26&rft.issue=45&rft.spage=11798&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Neurosci. 2000 Nov;3(11):1098-106 [11036266] Ann Neurol. 2006 Jul;60(1):105-17 [16802292] Neuron. 2000 Dec;28(3):873-86 [11163273] Nat Genet. 2001 Oct;29(2):160-5 [11586297] Nat Genet. 2001 Oct;29(2):166-73 [11586298] Nat Rev Neurosci. 2001 Nov;2(11):806-19 [11715057] J Neurosci. 2002 Apr 15;22(8):3005-15 [11943803] Nature. 2002 May 2;417(6884):83-7 [11986669] J Neurosci. 2002 Aug 15;22(16):6991-7005 [12177197] Trends Neurosci. 2002 Nov;25(11):578-88 [12392933] Am J Hum Genet. 2002 Nov;71(5):1189-94 [12355402] Neurochem Res. 2002 Oct;27(10):1093-104 [12462407] Neurosci Lett. 2003 Feb 27;338(2):107-10 [12566164] Hum Mol Genet. 2003 Jul 15;12(14):1671-87 [12837691] Neuron. 2003 Dec 18;40(6):1199-212 [14687553] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16041-6 [14668431] J Biol Chem. 2004 Jun 4;279(23):24612-23 [15033976] Annu Rev Neurosci. 2004;27:723-49 [15217349] Neuron. 2004 Jul 22;43(2):221-36 [15260958] Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6591-5 [8393571] Neurology. 1996 Oct;47(4 Suppl 2):S19-25; discussion S26 [8858047] J Comp Neurol. 1997 Feb 3;378(1):88-104 [9120056] Nature. 1997 Mar 20;386(6622):279-84 [9069286] J Neurol. 1997 May;244 Suppl 2:S3-14 [9178165] J Neurosci. 1997 Oct 1;17(19):7351-8 [9295381] Nat Neurosci. 1998 Nov;1(7):572-8 [10196564] Science. 1999 Jun 11;284(5421):1805-11 [10364547] Science. 1999 Jun 11;284(5421):1811-6 [10364548] J Neurosci. 1999 Aug 1;19(15):6519-27 [10414980] J Neurosci. 1999 Aug 1;19(15):6528-37 [10414981] J Neurosci. 1999 Aug 15;19(16):6930-41 [10436050] Biochim Biophys Acta. 2005 Aug 15;1745(1):84-100 [16085057] J Neurosci. 2005 Aug 17;25(33):7567-74 [16107644] Genes Dev. 2005 Sep 1;19(17):2000-15 [16107614] Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14434-9 [16186507] J Biol Chem. 2005 Oct 14;280(41):34735-40 [16049005] Ann Neurol. 2005 Nov;58(5):800-3 [16240357] Hum Mol Genet. 2006 Jan 15;15(2):233-50 [16321985] Neuron. 2006 Apr 6;50(1):75-88 [16600857] Nat Neurosci. 2006 May;9(5):636-41 [16582902] Nat Neurosci. 2006 May;9(5):602-4 [16582904] Ann Neurol. 2006 Jun;59(6):976-80 [16718699] Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600 [16769894] Curr Opin Neurobiol. 2006 Jun;16(3):281-7 [16698262] Curr Opin Neurobiol. 2006 Jun;16(3):288-97 [16713244] Brain. 2006 Jul;129(Pt 7):1710-9 [16670179] Ann Neurol. 2006 Jul;60(1):95-104 [16802286] Nat Neurosci. 2000 Dec;3(12):1282-90 [11100149] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Development of a substrate-based cyclic phosphopeptide inhibitor of protein phosphatase 2Cdelta, Wip1. AN - 69020789; 17073441 AB - The wild-type p53-induced phosphatase, Wip1 (PP2Cdelta or PPM1D) is a member of the protein phosphatase 2C (PP2C) family and functions as a negative regulator of the p38 MAP kinase-p53 signaling pathway. PPM1D is amplified or Wip1 is overexpressed in several human cancers, and it acts as a weak oncogene. Although inhibition of Wip1 may have therapeutic value, no specific inhibitors are available. In this study, we designed phosphopeptide inhibitors for Wip1 on the basis of its optimal substrate sequence. We found that phosphoserine-containing diphosphorylated peptides with the sequence pSXpY inhibited Wip1 phosphatase activity, whereas phosphothreonine-containing peptides with the sequence pTXpY were physiological substrates. Moreover, the X residue in the pSXpY sequence modulated inhibitor activity, and beta-branched amino acid-substituted (Ile or Val) phosphopeptides showed high inhibitory potencies. A thioether cyclic phosphopeptide c(MpSIpYVA) had a K(i) <1.0 microM. Two serine/threonine phosphatases, PP2Calpha and PP2A, were not significantly inhibited by the cyclic phosphopeptide with a nonhydrolyzable phosphoserine mimetic. A homology model of Wip1 bound to a cyclic phosphopeptide and site-directed mutagenesis helped to identify residues important for Wip1 inhibitor selectivity among the PP2C family. These results provide the first proof of concept of a specific inhibitor of the catalytic site of Wip1 and should be useful for developing potential anti-cancer drugs. JF - Biochemistry AU - Yamaguchi, Hiroshi AU - Durell, Stewart R AU - Feng, Hanqiao AU - Bai, Yawen AU - Anderson, Carl W AU - Appella, Ettore AD - Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/11/07/ PY - 2006 DA - 2006 Nov 07 SP - 13193 EP - 13202 VL - 45 IS - 44 SN - 0006-2960, 0006-2960 KW - Enzyme Inhibitors KW - 0 KW - Phosphopeptides KW - PPM1A protein, human KW - EC 3.1.3.16 KW - PPM1B protein, human KW - PPM1D protein, human KW - PPM1G protein, human KW - Phosphoprotein Phosphatases KW - Protein Phosphatase 2C KW - Index Medicus KW - Models, Molecular KW - Nuclear Magnetic Resonance, Biomolecular KW - Humans KW - Molecular Sequence Data KW - Catalytic Domain KW - Circular Dichroism KW - Amino Acid Sequence KW - Substrate Specificity KW - Phosphoprotein Phosphatases -- antagonists & inhibitors KW - Phosphopeptides -- pharmacology KW - Enzyme Inhibitors -- chemistry KW - Phosphoprotein Phosphatases -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Phosphoprotein Phosphatases -- chemistry KW - Phosphopeptides -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69020789?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Development+of+a+substrate-based+cyclic+phosphopeptide+inhibitor+of+protein+phosphatase+2Cdelta%2C+Wip1.&rft.au=Yamaguchi%2C+Hiroshi%3BDurell%2C+Stewart+R%3BFeng%2C+Hanqiao%3BBai%2C+Yawen%3BAnderson%2C+Carl+W%3BAppella%2C+Ettore&rft.aulast=Yamaguchi&rft.aufirst=Hiroshi&rft.date=2006-11-07&rft.volume=45&rft.issue=44&rft.spage=13193&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-15 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases. AN - 68123622; 17075046 AB - The silent information regulator 2 (Sir2) family of NAD-dependent N-acetyl-protein deacetylases participates in the regulation of gene silencing, chromatin structure, and longevity. In the Sir2-catalyzed reaction, the acetyl moiety of N-acetyl-histone is transferred to the ADP-ribose of NAD, yielding O-acetyl-ADP-ribose and nicotinamide. We hypothesized that, if O-acetyl-ADP-ribose were an important signaling molecule, a specific hydrolase would cleave the (O-acetyl)-(ADP-ribose) linkage. We report here that the poly(ADP-ribose) glycohydrolase ARH3 hydrolyzed O-acetyl-ADP-ribose to produce ADP-ribose in a time- and Mg(2+)-dependent reaction and thus could participate in two signaling pathways. This O-acetyl-ADP-ribose hydrolase belongs to a family of three structurally related 39-kDa ADP-ribose-binding proteins (ARH1-ARH3). ARH1 was reported to hydrolyze ADP-ribosylarginine, whereas ARH3 degraded poly(ADP-ribose). ARH3-catalyzed generation of ADP-ribose from O-acetyl-ADP-ribose was significantly faster than from poly(ADP-ribose). Like the degradation of poly(ADP-ribose) by ARH3, hydrolysis of O-acetyl-ADP-ribose was abolished by replacement of the vicinal aspartates at positions 77 and 78 of ARH3 with asparagine. The rate of O-acetyl-ADP-ribose hydrolysis by recombinant ARH3 was 250-fold that observed with ARH1; ARH2 and poly(ADP-ribose) glycohydrolase were inactive. All data support the conclusion that the Sir2 reaction product O-acetyl-ADP-ribose is degraded by ARH3. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Ono, Tohru AU - Kasamatsu, Atsushi AU - Oka, Shunya AU - Moss, Joel AD - Pulmonary-Critical Care Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1590, USA. Y1 - 2006/11/07/ PY - 2006 DA - 2006 Nov 07 SP - 16687 EP - 16691 VL - 103 IS - 45 SN - 0027-8424, 0027-8424 KW - O-Acetyl-ADP-Ribose KW - 0 KW - Recombinant Proteins KW - Glycoside Hydrolases KW - EC 3.2.1.- KW - ADPRHL2 protein, human KW - EC 3.2.1.143 KW - SIRT1 protein, human KW - EC 3.5.1.- KW - Sirtuin 1 KW - Sirtuins KW - Magnesium KW - I38ZP9992A KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Magnesium -- metabolism KW - Recombinant Proteins -- metabolism KW - Kinetics KW - Humans KW - In Vitro Techniques KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization KW - Recombinant Proteins -- chemistry KW - Recombinant Proteins -- genetics KW - Hydrolysis KW - Molecular Weight KW - Amino Acid Substitution KW - Glycoside Hydrolases -- chemistry KW - Sirtuins -- metabolism KW - Glycoside Hydrolases -- metabolism KW - Glycoside Hydrolases -- genetics KW - O-Acetyl-ADP-Ribose -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68123622?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=The+39-kDa+poly%28ADP-ribose%29+glycohydrolase+ARH3+hydrolyzes+O-acetyl-ADP-ribose%2C+a+product+of+the+Sir2+family+of+acetyl-histone+deacetylases.&rft.au=Ono%2C+Tohru%3BKasamatsu%2C+Atsushi%3BOka%2C+Shunya%3BMoss%2C+Joel&rft.aulast=Ono&rft.aufirst=Tohru&rft.date=2006-11-07&rft.volume=103&rft.issue=45&rft.spage=16687&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-20 N1 - Date created - 2006-11-08 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):415-20 [11134535] Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14178-82 [11106374] EMBO J. 2002 May 15;21(10):2383-96 [12006491] J Biol Chem. 2002 May 24;277(21):18535-44 [11893743] Protein Sci. 2002 Jul;11(7):1657-70 [12070318] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13653-8 [12374852] J Biol Chem. 2002 Dec 6;277(49):47114-22 [12370179] Mol Cell. 2003 Feb;11(2):437-44 [12620231] Microbiol Mol Biol Rev. 2003 Sep;67(3):376-99, table of contents [12966141] Proc Natl Acad Sci U S A. 1985 Sep;82(17):5603-7 [2994036] Biochemistry. 1986 Sep 23;25(19):5408-14 [3778868] J Biol Chem. 1992 May 25;267(15):10481-8 [1375222] J Biol Chem. 1993 Aug 25;268(24):17837-43 [8349667] Physiol Rev. 1995 Oct;75(4):725-48 [7480160] J Biol Chem. 1998 Sep 11;273(37):23617-20 [9726960] J Biol Chem. 1999 Jun 11;274(24):16736-40 [10358013] Biochem Biophys Res Commun. 1999 Jun 24;260(1):273-9 [10381378] Biochem J. 2005 Jun 1;388(Pt 2):493-500 [15658938] Cell. 2005 May 20;121(4):515-27 [15907466] Nat Struct Mol Biol. 2005 Jul;12(7):624-5 [15965484] Mol Biol Cell. 2005 Oct;16(10):4623-35 [16079181] J Biol Chem. 2006 Jan 13;281(2):705-13 [16278211] Cell Mol Life Sci. 2006 Jan;63(2):123-43 [16378245] Genes Dev. 2000 May 1;14(9):1021-6 [10809662] Biochem Biophys Res Commun. 2000 Jul 5;273(2):793-8 [10873683] J Biol Chem. 2002 Apr 12;277(15):12632-41 [11812793] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CLA-1 and its splicing variant CLA-2 mediate bacterial adhesion and cytosolic bacterial invasion in mammalian cells AN - 19396735; 7167590 AB - CD36 and LIMPII analog 1, CLA-1, and its splicing variant, CLA-2 (SR-BI and SR-BII in rodents), are human high density lipoprotein receptors with an identical extracellular domain which binds a spectrum of ligands including bacterial cell wall components. In this study, CLA-1- and CLA-2-stably transfected HeLa and HEK293 cells demonstrated several-fold increases in the uptake of various bacteria over mock-transfected cells. All bacteria tested, including both Gram-negatives (Escherichia coli K12, K1 and Salmonella typhimurium) and Gram-positives (Staphylococcus aureus and Listeria monocytogenes), demonstrated various degrees of lower uptake in control cells. This result is consistent with the presence of high-density lipoprotein-receptor-independent bacterial uptake that is enhanced by CLA-1/CLA-2 overexpression. Bacterial lipopolysaccharides, lipoteichoic acid, and synthetic amphipathic helical peptides (L-37pA and D-37pA) competed with E. coli K12 for CLA-1 and CLA-2 binding. Transmission electron microscopy and confocal microscopy revealed cytosolic accumulation of bacteria in CLA-1/CLA-2-overexpressing HeLa cells. The antibiotic protection assay confirmed that E. coli K12 was able to survive and replicate intracellularly in CLA-1- and CLA-2-overexpressing HeLa, but both L-37pA and D-37pA prevented E. coli K12 invasion. Peritoneal macrophages isolated from SR-BI/BII-knockout mice demonstrated a 30% decrease in bacterial uptake when compared with macrophages from normal mice. Knockout macrophages were also characterized by decreased bacterial cytosolic invasion, ubiquitination, and proteasome mobilization while retaining bacterial lysosomal accumulation. These results indicate that, by facilitating bacterial adhesion and cytosolic invasion, CLA-1 and CLA-2 may play an important role in infection and sepsis. JF - Proceedings of the National Academy of Sciences, USA AU - Vishnyakova, Tatyana G AU - Kurlander, Roger AU - Bocharov, Alexander V AU - Baranova, Irina N AU - Chen, Zhigang AU - Abu-Asab, Mones S AU - Tsokos, Maria AU - Malide, Daniela AU - Basso, Federica AU - Remaley, Alan AU - Csako, Gyorgy AU - Eggerman, Thomas L AU - Patterson, Amy P AD - National Heart, Lung, and Blood Institute, Light Microscopy Core Facility, National Heart, Lung, and Blood Institute, Department of Laboratory Medicine, Clinical Center, National Cancer Institute, and the Division of Diabetes, Endocrinology, and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/11/07/ PY - 2006 DA - 2006 Nov 07 SP - 16888 EP - 16893 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 45 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Listeria monocytogenes KW - CD36 antigen KW - Transmission electron microscopy KW - Peritoneum KW - proteasomes KW - Antibiotics KW - Salmonella typhimurium KW - Infection KW - Lipoteichoic acid KW - ubiquitination KW - Lipoprotein (high density) receptors KW - Splicing KW - Sepsis KW - Mammalian cells KW - Confocal microscopy KW - Escherichia coli KW - Lipopolysaccharides KW - Staphylococcus aureus KW - Cell walls KW - A 01340:Antibiotics & Antimicrobials KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19396735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=CLA-1+and+its+splicing+variant+CLA-2+mediate+bacterial+adhesion+and+cytosolic+bacterial+invasion+in+mammalian+cells&rft.au=Vishnyakova%2C+Tatyana+G%3BKurlander%2C+Roger%3BBocharov%2C+Alexander+V%3BBaranova%2C+Irina+N%3BChen%2C+Zhigang%3BAbu-Asab%2C+Mones+S%3BTsokos%2C+Maria%3BMalide%2C+Daniela%3BBasso%2C+Federica%3BRemaley%2C+Alan%3BCsako%2C+Gyorgy%3BEggerman%2C+Thomas+L%3BPatterson%2C+Amy+P&rft.aulast=Vishnyakova&rft.aufirst=Tatyana&rft.date=2006-11-07&rft.volume=103&rft.issue=45&rft.spage=16888&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; CD36 antigen; Transmission electron microscopy; Peritoneum; proteasomes; Antibiotics; Infection; Lipoteichoic acid; ubiquitination; Sepsis; Splicing; Lipoprotein (high density) receptors; Mammalian cells; Confocal microscopy; Lipopolysaccharides; Cell walls; Listeria monocytogenes; Escherichia coli; Staphylococcus aureus; Salmonella typhimurium ER - TY - CPAPER T1 - The use of Gene Expression Profiles with Traditional Toxicology to Better Understand Adverse Effects from Environmental Exposures on Human Health T2 - 27th Annual Meeting of the American College of Toxicology AN - 40529388; 4515629 JF - 27th Annual Meeting of the American College of Toxicology AU - Paules, Richard S Y1 - 2006/11/05/ PY - 2006 DA - 2006 Nov 05 KW - Side effects KW - Gene expression KW - Public health KW - Environmental factors KW - Toxicology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40529388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.atitle=The+use+of+Gene+Expression+Profiles+with+Traditional+Toxicology+to+Better+Understand+Adverse+Effects+from+Environmental+Exposures+on+Human+Health&rft.au=Paules%2C+Richard+S&rft.aulast=Paules&rft.aufirst=Richard&rft.date=2006-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.actox.org/attmtg/PROGRAM.06.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Institute for Environmental Health Sciences Efforts to Evaluate the Human Health Hazards Associated with Exposure to Nanomaterials T2 - 27th Annual Meeting of the American College of Toxicology AN - 40528806; 4515690 JF - 27th Annual Meeting of the American College of Toxicology AU - Walker, Nigel Y1 - 2006/11/05/ PY - 2006 DA - 2006 Nov 05 KW - Environmental health KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40528806?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.atitle=National+Institute+for+Environmental+Health+Sciences+Efforts+to+Evaluate+the+Human+Health+Hazards+Associated+with+Exposure+to+Nanomaterials&rft.au=Walker%2C+Nigel&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2006-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.actox.org/attmtg/PROGRAM.06.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building a Model from Direct Measurements of Components of the Model T2 - 27th Annual Meeting of the American College of Toxicology AN - 40524086; 4515667 JF - 27th Annual Meeting of the American College of Toxicology AU - Portier, Christopher J Y1 - 2006/11/05/ PY - 2006 DA - 2006 Nov 05 KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40524086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.atitle=Building+a+Model+from+Direct+Measurements+of+Components+of+the+Model&rft.au=Portier%2C+Christopher+J&rft.aulast=Portier&rft.aufirst=Christopher&rft.date=2006-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=27th+Annual+Meeting+of+the+American+College+of+Toxicology&rft.issn=&rft_id=info:doi/ L2 - http://www.actox.org/attmtg/PROGRAM.06.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vaginal Reconstruction Using a Combined Greater Omentum-Pedicled Flap and Vicryl Mesh Repair Following Anterior Pelvic Excentration T2 - XVIII FIGO World Congress of Gynecology and Obstetrics (FIGO 2006) AN - 40477886; 4489201 JF - XVIII FIGO World Congress of Gynecology and Obstetrics (FIGO 2006) AU - Elaffandi, Ahmed Y1 - 2006/11/05/ PY - 2006 DA - 2006 Nov 05 KW - Vagina KW - Pelvis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40477886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVIII+FIGO+World+Congress+of+Gynecology+and+Obstetrics+%28FIGO+2006%29&rft.atitle=Vaginal+Reconstruction+Using+a+Combined+Greater+Omentum-Pedicled+Flap+and+Vicryl+Mesh+Repair+Following+Anterior+Pelvic+Excentration&rft.au=Elaffandi%2C+Ahmed&rft.aulast=Elaffandi&rft.aufirst=Ahmed&rft.date=2006-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVIII+FIGO+World+Congress+of+Gynecology+and+Obstetrics+%28FIGO+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.figo2006kl.com/marketroot/figo2006kl/catalog/file/FigoProgr amme.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Current NIH Support for Dietary Supplement Research T2 - 7th International Conference and Exhibition on Nutraceuticals and Functional Foods (Worldnutra 2006) AN - 40426804; 4451635 JF - 7th International Conference and Exhibition on Nutraceuticals and Functional Foods (Worldnutra 2006) AU - Swanson, Christine Y1 - 2006/11/05/ PY - 2006 DA - 2006 Nov 05 KW - Dietary supplements KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40426804?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=7th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28Worldnutra+2006%29&rft.atitle=Current+NIH+Support+for+Dietary+Supplement+Research&rft.au=Swanson%2C+Christine&rft.aulast=Swanson&rft.aufirst=Christine&rft.date=2006-11-05&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=7th+International+Conference+and+Exhibition+on+Nutraceuticals+and+Functional+Foods+%28Worldnutra+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.worldnutra.com/2006/conference/program/details/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health Intervention after the 2004 Mid Niigata Earthquake ---Part 2: Team Management T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40502209; 4492709 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Nakajima, Satomi AU - Kim, Yoshiharu AU - Shimada, Kyoko AU - Fukushima, Noboru Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Earthquakes KW - Health promotion KW - Seismic activity KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40502209?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=Mental+Health+Intervention+after+the+2004+Mid+Niigata+Earthquake+---Part+2%3A+Team+Management&rft.au=Nakajima%2C+Satomi%3BKim%2C+Yoshiharu%3BShimada%2C+Kyoko%3BFukushima%2C+Noboru&rft.aulast=Nakajima&rft.aufirst=Satomi&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PTSD among those who Experienced Loss of their Family Members by Traffic Accident in Japan T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40500469; 4492593 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Shirai, Akemi AU - Konishi, Takako Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Japan KW - Traffic KW - Accidents KW - Post-traumatic stress disorder UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40500469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=PTSD+among+those+who+Experienced+Loss+of+their+Family+Members+by+Traffic+Accident+in+Japan&rft.au=Shirai%2C+Akemi%3BKonishi%2C+Takako&rft.aulast=Shirai&rft.aufirst=Akemi&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mental Health Intervention after the 2004 Mid Niigata Earthquake---Part 1: Individual Distress T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40500460; 4492702 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Kim, Yoshiharu AU - Nakajima, Satomi AU - Shimada, Kyoko AU - Fukushima, Noboru Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Health promotion KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40500460?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=Mental+Health+Intervention+after+the+2004+Mid+Niigata+Earthquake---Part+1%3A+Individual+Distress&rft.au=Kim%2C+Yoshiharu%3BNakajima%2C+Satomi%3BShimada%2C+Kyoko%3BFukushima%2C+Noboru&rft.aulast=Kim&rft.aufirst=Yoshiharu&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NIH Support for Alcohol, Drug Abuse and Mental Health Research T2 - 2006 Annual Meeting of International Society for Traumatic Stress Studies AN - 40490934; 4492800 JF - 2006 Annual Meeting of International Society for Traumatic Stress Studies AU - Tuma, Farris AU - Price, LeShawndra AU - Juliano, Denise AU - Noursi, Samia AU - Boyce, Cheryl Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Alcohols KW - Drug abuse KW - Ethanol KW - Mental disorders UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40490934?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.atitle=NIH+Support+for+Alcohol%2C+Drug+Abuse+and+Mental+Health+Research&rft.au=Tuma%2C+Farris%3BPrice%2C+LeShawndra%3BJuliano%2C+Denise%3BNoursi%2C+Samia%3BBoyce%2C+Cheryl&rft.aulast=Tuma&rft.aufirst=Farris&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+of+International+Society+for+Traumatic+Stress+Studies&rft.issn=&rft_id=info:doi/ L2 - http://www.istss.org/meetings/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developing Research and Researchers to Address Drugs and Criminalization in African Americans T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39353330; 4463901 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Beatty, Lula Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Ethnic groups KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Developing+Research+and+Researchers+to+Address+Drugs+and+Criminalization+in+African+Americans&rft.au=Beatty%2C+Lula&rft.aulast=Beatty&rft.aufirst=Lula&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - It's Broke. Can we Fix It?: A Community Forum Theater Dialogue on Disparities in Access to Health Care T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39298656; 4463396 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, John Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Health care KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39298656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=It%27s+Broke.+Can+we+Fix+It%3F%3A+A+Community+Forum+Theater+Dialogue+on+Disparities+in+Access+to+Health+Care&rft.au=Sullivan%2C+John&rft.aulast=Sullivan&rft.aufirst=John&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dietary Intakes of Nutrients in Drinkers: National Health and Nutrition Examination Survey (NHANES 1999-2002) T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39297227; 4461404 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Breslow, Rosalind A AU - Juan, Wenyen AU - Guenther, Patricia M Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Nutrition KW - Ingestion KW - Diets KW - Dietary intake KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39297227?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Dietary+Intakes+of+Nutrients+in+Drinkers%3A+National+Health+and+Nutrition+Examination+Survey+%28NHANES+1999-2002%29&rft.au=Breslow%2C+Rosalind+A%3BJuan%2C+Wenyen%3BGuenther%2C+Patricia+M&rft.aulast=Breslow&rft.aufirst=Rosalind&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Right to Choose? CAM use and Health Decision Making in Minority Patients with Rheumatic Diseases T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39296640; 4464369 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Rivera-Goba, Migdalia V AU - Wallen, Gwenyth R AU - Mendoza, Juan AU - Longstaff, Laura AU - Schuett, Nicole AU - Miranda-Acevedo, Robert AU - Carrington, Keli AU - Austin, Janet AU - Koziol, Deloris AU - Dennis, Gregory AU - Mittlleman, Barbara Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Rheumatic diseases KW - Decision making KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39296640?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=A+Right+to+Choose%3F+CAM+use+and+Health+Decision+Making+in+Minority+Patients+with+Rheumatic+Diseases&rft.au=Rivera-Goba%2C+Migdalia+V%3BWallen%2C+Gwenyth+R%3BMendoza%2C+Juan%3BLongstaff%2C+Laura%3BSchuett%2C+Nicole%3BMiranda-Acevedo%2C+Robert%3BCarrington%2C+Keli%3BAustin%2C+Janet%3BKoziol%2C+Deloris%3BDennis%2C+Gregory%3BMittlleman%2C+Barbara&rft.aulast=Rivera-Goba&rft.aufirst=Migdalia&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - States' Role in Increasing Priority Populations' Accrual to Cancer Clinical Trials T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39295342; 4460579 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Arculli, Regina El AU - Baker, Carissa AU - Lowrey, Kerri M AU - Schober, Melissa Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Clinical trials KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39295342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=States%27+Role+in+Increasing+Priority+Populations%27+Accrual+to+Cancer+Clinical+Trials&rft.au=Arculli%2C+Regina+El%3BBaker%2C+Carissa%3BLowrey%2C+Kerri+M%3BSchober%2C+Melissa&rft.aulast=Arculli&rft.aufirst=Regina&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acknowledging the Forgotten Child: Using a National Cancer Institute Model to Develop a Resource for Young People who have a Sibling with Cancer T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39293102; 4463346 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Sienche, Carol AU - Inokuchi, Derek AU - Ammary, Neyal J AU - Thakkar, Sona S Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Cancer KW - Siblings KW - Models KW - Resource development KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39293102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Acknowledging+the+Forgotten+Child%3A+Using+a+National+Cancer+Institute+Model+to+Develop+a+Resource+for+Young+People+who+have+a+Sibling+with+Cancer&rft.au=Sienche%2C+Carol%3BInokuchi%2C+Derek%3BAmmary%2C+Neyal+J%3BThakkar%2C+Sona+S&rft.aulast=Sienche&rft.aufirst=Carol&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - African Americans and the Triad of Drugs, HIV and Criminalization: Research, Training and Service Needs T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39292642; 4463902 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Vereen, Donald Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Training KW - Drugs KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=African+Americans+and+the+Triad+of+Drugs%2C+HIV+and+Criminalization%3A+Research%2C+Training+and+Service+Needs&rft.au=Vereen%2C+Donald&rft.aulast=Vereen&rft.aufirst=Donald&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LactMed: A New Database on Drugs and Lactation from the National Library of Medicine T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39290109; 4462935 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Wexler, Philip AU - Anderson, Philip O AU - Knoben, James E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Drugs KW - Lactation KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=LactMed%3A+A+New+Database+on+Drugs+and+Lactation+from+the+National+Library+of+Medicine&rft.au=Wexler%2C+Philip%3BAnderson%2C+Philip+O%3BKnoben%2C+James+E&rft.aulast=Wexler&rft.aufirst=Philip&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy Vision Community Awards Program T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39287628; 4463533 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Janiszewski, Rosemary AU - Ammary, Neyal J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Healthy+Vision+Community+Awards+Program&rft.au=Janiszewski%2C+Rosemary%3BAmmary%2C+Neyal+J&rft.aulast=Janiszewski&rft.aufirst=Rosemary&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Worksite Wellness in Obesity Prevention Efforts T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39286008; 4461078 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Johnson-Taylor, Wendy Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Prevention KW - Obesity KW - Working conditions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39286008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Role+of+Worksite+Wellness+in+Obesity+Prevention+Efforts&rft.au=Johnson-Taylor%2C+Wendy&rft.aulast=Johnson-Taylor&rft.aufirst=Wendy&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Tobacco Withdrawal Continuum using Item Response Theory T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39280609; 4460124 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Saha, Tulshi D Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39280609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Assessing+Tobacco+Withdrawal+Continuum+using+Item+Response+Theory&rft.au=Saha%2C+Tulshi+D&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effective Intervention Strategies to Reduce Drugs, HIV and Incarceration among African Americans T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39270724; 4463904 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Jones, Dionne J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Ethnic groups KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Effective+Intervention+Strategies+to+Reduce+Drugs%2C+HIV+and+Incarceration+among+African+Americans&rft.au=Jones%2C+Dionne+J&rft.aulast=Jones&rft.aufirst=Dionne&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Assessing Smoking in University Students in Rio De Janeiro T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39270422; 4460025 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Figueiredo, Valeska AU - Wong, Julio AU - Smith, Katherine Clegg AU - Stillman, Frances Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Brazil, Rio de Janeiro KW - Smoking KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Assessing+Smoking+in+University+Students+in+Rio+De+Janeiro&rft.au=Figueiredo%2C+Valeska%3BWong%2C+Julio%3BSmith%2C+Katherine+Clegg%3BStillman%2C+Frances&rft.aulast=Figueiredo&rft.aufirst=Valeska&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do Human Rights Provide an Adequate Moral Framework for Public Health?: A Critical Appraisal T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39270067; 4464526 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Wasson, Katherine Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Public health KW - Human rights KW - Ethics KW - Evaluation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Do+Human+Rights+Provide+an+Adequate+Moral+Framework+for+Public+Health%3F%3A+A+Critical+Appraisal&rft.au=Wasson%2C+Katherine&rft.aulast=Wasson&rft.aufirst=Katherine&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building a Model for Research Dissemination: Gaining Adoption for Body & Soul T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39267161; 4461073 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Lenora E AU - Solomon, Felicia M AU - Baum, Herb AU - Williams, Alexis AU - McCoy, Lisa AU - Bartholomew, Jill AU - Duncan, Taira AU - Robinson, JaMuir Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Models KW - Adoption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39267161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Building+a+Model+for+Research+Dissemination%3A+Gaining+Adoption+for+Body+%26amp%3B+Soul&rft.au=Johnson%2C+Lenora+E%3BSolomon%2C+Felicia+M%3BBaum%2C+Herb%3BWilliams%2C+Alexis%3BMcCoy%2C+Lisa%3BBartholomew%2C+Jill%3BDuncan%2C+Taira%3BRobinson%2C+JaMuir&rft.aulast=Johnson&rft.aufirst=Lenora&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Talks & Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk & Assessing Needs in the Wake of Hurricanes Katrina & Rita T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39266368; 4460862 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, John AU - Bryan, L Parras AU - Gorenstein, Jennifer AU - Fuchs-Young, Robin AU - Diamond, Pam Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Hurricanes KW - Environmental health KW - Public health KW - Environmental assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39266368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=How+Color+Coding+Formulaic+Writing+Enhances+Organization%3A+A+Qualitative+Approach+for+Measuring+Student+Affect&rft.au=Geigle%2C+Bryce+A.&rft.aulast=Geigle&rft.aufirst=Bryce&rft.date=2014-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Self-Medication with Alcohol and Co-Morbid Alcohol use Disorders among Individuals with Mood and Anxiety Disorders T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39264948; 4460090 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Lakins, Nekisha E AU - Yi, Hsiao-ye AU - Yahr, Harold T AU - Falk, Daniel E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Alcohols KW - Anxiety KW - Mood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Relationship+between+Self-Medication+with+Alcohol+and+Co-Morbid+Alcohol+use+Disorders+among+Individuals+with+Mood+and+Anxiety+Disorders&rft.au=Lakins%2C+Nekisha+E%3BYi%2C+Hsiao-ye%3BYahr%2C+Harold+T%3BFalk%2C+Daniel+E&rft.aulast=Lakins&rft.aufirst=Nekisha&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Analysis of the Willingness of Cardiac Patients for Referral Treatment from a Military Medical Center to Affiliated Community Clinics in Taiwan T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39263812; 4462560 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Ying, Lai Chao Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Taiwan KW - Military KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=An+Analysis+of+the+Willingness+of+Cardiac+Patients+for+Referral+Treatment+from+a+Military+Medical+Center+to+Affiliated+Community+Clinics+in+Taiwan&rft.au=Ying%2C+Lai+Chao&rft.aulast=Ying&rft.aufirst=Lai&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Tailored Fruit and Vegetable Print Intervention for African Americans Based on Motivational Interviewing and Self Determination Theory T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39248919; 4463370 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Shaikh, Abdul R I AU - Stone, Jana L AU - Martin, Lisa A AU - Davis, Rachel AU - Zhang, Guangyu AU - Hawkins, Jennifer J AU - Hinchman, Josephine AU - Alexander, Gwen L AU - Resnicow, Ken Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Fruits KW - Ethnic groups KW - Vegetables KW - Self KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39248919?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=A+Tailored+Fruit+and+Vegetable+Print+Intervention+for+African+Americans+Based+on+Motivational+Interviewing+and+Self+Determination+Theory&rft.au=Shaikh%2C+Abdul+R+I%3BStone%2C+Jana+L%3BMartin%2C+Lisa+A%3BDavis%2C+Rachel%3BZhang%2C+Guangyu%3BHawkins%2C+Jennifer+J%3BHinchman%2C+Josephine%3BAlexander%2C+Gwen+L%3BResnicow%2C+Ken&rft.aulast=Shaikh&rft.aufirst=Abdul+R&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Library of Medicine Tools and Resources for Responding to Chemical and Radiological Events T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39246993; 4461879 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Szczur, Marti AU - Chang, Florence AU - Mashayekhi, Bijan Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Disasters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=National+Library+of+Medicine+Tools+and+Resources+for+Responding+to+Chemical+and+Radiological+Events&rft.au=Szczur%2C+Marti%3BChang%2C+Florence%3BMashayekhi%2C+Bijan&rft.aulast=Szczur&rft.aufirst=Marti&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Do Tobacco Control Policies Reduce Tobacco use among Low SES Women and Girls? T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39245738; 4460284 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Fagan, Pebbles AU - McLellan, Deborah L AU - Levy, Anna T AU - Kaufman, Nancy J AU - Jones, Wanda K Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39245738?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Do+Tobacco+Control+Policies+Reduce+Tobacco+use+among+Low+SES+Women+and+Girls%3F&rft.au=Fagan%2C+Pebbles%3BMcLellan%2C+Deborah+L%3BLevy%2C+Anna+T%3BKaufman%2C+Nancy+J%3BJones%2C+Wanda+K&rft.aulast=Fagan&rft.aufirst=Pebbles&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Drugs, HIV and Incarceration among African Americans: Research Needs and Intervention Strategies T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39220746; 4463903 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Jones, Dionne J AU - Beatty, Lula Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Ethnic groups KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39220746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Drugs%2C+HIV+and+Incarceration+among+African+Americans%3A+Research+Needs+and+Intervention+Strategies&rft.au=Jones%2C+Dionne+J%3BBeatty%2C+Lula&rft.aulast=Jones&rft.aufirst=Dionne&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Cancer Education Messages: Reactions of At-Risk African American Men in Washington, D.C T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39205660; 4462479 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Boehm, Karina AU - Daum, Mary AU - Doner, Lynne Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, Washington KW - Africa KW - Ethnic groups KW - Education KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39205660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Oral+Cancer+Education+Messages%3A+Reactions+of+At-Risk+African+American+Men+in+Washington%2C+D.C&rft.au=Boehm%2C+Karina%3BDaum%2C+Mary%3BDoner%2C+Lynne&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Jonathan Mann, HIV/AIDS, and Human Rights T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39204465; 4464193 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Fee, Elizabeth AU - Parry, Manon Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Human immunodeficiency virus KW - Human rights KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Jonathan+Mann%2C+HIV%2FAIDS%2C+and+Human+Rights&rft.au=Fee%2C+Elizabeth%3BParry%2C+Manon&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2006-11-04&rft.volume=15&rft.issue=11&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER -