TY - CPAPER T1 - Developing Research and Researchers to Address Drugs and Criminalization in African Americans T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39353330; 4463901 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Beatty, Lula Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Ethnic groups KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Developing+Research+and+Researchers+to+Address+Drugs+and+Criminalization+in+African+Americans&rft.au=Beatty%2C+Lula&rft.aulast=Beatty&rft.aufirst=Lula&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Patient Reported Outcomes in Medical Practice and Research: Update on the NIH PROMIS Initiative T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39351008; 4462589 DE: JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Riley, William AU - Reeve, Bryce Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Measurement+of+Patient+Reported+Outcomes+in+Medical+Practice+and+Research%3A+Update+on+the+NIH+PROMIS+Initiative&rft.au=Riley%2C+William%3BReeve%2C+Bryce&rft.aulast=Riley&rft.aufirst=William&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's Small Grants Program for Behavioral Research in Cancer Control: Boosts Careers for Junior Investigators and Fulfils NIH goal T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39349110; 4463435 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Chollette, Veronica Y AU - Crowley, Kathleen Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Cancer KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=National+Cancer+Institute%27s+Small+Grants+Program+for+Behavioral+Research+in+Cancer+Control%3A+Boosts+Careers+for+Junior+Investigators+and+Fulfils+NIH+goal&rft.au=Chollette%2C+Veronica+Y%3BCrowley%2C+Kathleen&rft.aulast=Chollette&rft.aufirst=Veronica&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - African Americans and the Triad of Drugs, HIV and Criminalization: Research, Training and Service Needs T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39292642; 4463902 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Vereen, Donald Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Training KW - Drugs KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=African+Americans+and+the+Triad+of+Drugs%2C+HIV+and+Criminalization%3A+Research%2C+Training+and+Service+Needs&rft.au=Vereen%2C+Donald&rft.aulast=Vereen&rft.aufirst=Donald&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LactMed: A New Database on Drugs and Lactation from the National Library of Medicine T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39290109; 4462935 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Wexler, Philip AU - Anderson, Philip O AU - Knoben, James E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Drugs KW - Lactation KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=LactMed%3A+A+New+Database+on+Drugs+and+Lactation+from+the+National+Library+of+Medicine&rft.au=Wexler%2C+Philip%3BAnderson%2C+Philip+O%3BKnoben%2C+James+E&rft.aulast=Wexler&rft.aufirst=Philip&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy Vision Community Awards Program T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39287628; 4463533 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Janiszewski, Rosemary AU - Ammary, Neyal J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Healthy+Vision+Community+Awards+Program&rft.au=Janiszewski%2C+Rosemary%3BAmmary%2C+Neyal+J&rft.aulast=Janiszewski&rft.aufirst=Rosemary&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building a Model for Research Dissemination: Gaining Adoption for Body & Soul T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39267161; 4461073 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Lenora E AU - Solomon, Felicia M AU - Baum, Herb AU - Williams, Alexis AU - McCoy, Lisa AU - Bartholomew, Jill AU - Duncan, Taira AU - Robinson, JaMuir Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Models KW - Adoption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39267161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Building+a+Model+for+Research+Dissemination%3A+Gaining+Adoption+for+Body+%26amp%3B+Soul&rft.au=Johnson%2C+Lenora+E%3BSolomon%2C+Felicia+M%3BBaum%2C+Herb%3BWilliams%2C+Alexis%3BMcCoy%2C+Lisa%3BBartholomew%2C+Jill%3BDuncan%2C+Taira%3BRobinson%2C+JaMuir&rft.aulast=Johnson&rft.aufirst=Lenora&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Talks & Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk & Assessing Needs in the Wake of Hurricanes Katrina & Rita T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39266368; 4460862 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, John AU - Bryan, L Parras AU - Gorenstein, Jennifer AU - Fuchs-Young, Robin AU - Diamond, Pam Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Hurricanes KW - Environmental health KW - Public health KW - Environmental assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39266368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=How+Color+Coding+Formulaic+Writing+Enhances+Organization%3A+A+Qualitative+Approach+for+Measuring+Student+Affect&rft.au=Geigle%2C+Bryce+A.&rft.aulast=Geigle&rft.aufirst=Bryce&rft.date=2014-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Self-Medication with Alcohol and Co-Morbid Alcohol use Disorders among Individuals with Mood and Anxiety Disorders T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39264948; 4460090 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Lakins, Nekisha E AU - Yi, Hsiao-ye AU - Yahr, Harold T AU - Falk, Daniel E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Alcohols KW - Anxiety KW - Mood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Relationship+between+Self-Medication+with+Alcohol+and+Co-Morbid+Alcohol+use+Disorders+among+Individuals+with+Mood+and+Anxiety+Disorders&rft.au=Lakins%2C+Nekisha+E%3BYi%2C+Hsiao-ye%3BYahr%2C+Harold+T%3BFalk%2C+Daniel+E&rft.aulast=Lakins&rft.aufirst=Nekisha&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Analysis of the Willingness of Cardiac Patients for Referral Treatment from a Military Medical Center to Affiliated Community Clinics in Taiwan T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39263812; 4462560 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Ying, Lai Chao Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Taiwan KW - Military KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=An+Analysis+of+the+Willingness+of+Cardiac+Patients+for+Referral+Treatment+from+a+Military+Medical+Center+to+Affiliated+Community+Clinics+in+Taiwan&rft.au=Ying%2C+Lai+Chao&rft.aulast=Ying&rft.aufirst=Lai&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research Priorities: Tobacco Control Policies to Reduce Tobacco use among Low SES Women and Girls T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39260896; 4460286 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Levy, Anna T AU - McLellan, Deborah L AU - Fagan, Pebbles AU - Jones, Wanda K AU - Kaufman, Nancy J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Research+Priorities%3A+Tobacco+Control+Policies+to+Reduce+Tobacco+use+among+Low+SES+Women+and+Girls&rft.au=Levy%2C+Anna+T%3BMcLellan%2C+Deborah+L%3BFagan%2C+Pebbles%3BJones%2C+Wanda+K%3BKaufman%2C+Nancy+J&rft.aulast=Levy&rft.aufirst=Anna&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Perceived Racism and Race-Based Residential Segregation on Cancer Behavioral Risk Profiles: A Study of Asian Americans and Pacific Islanders in California T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39258609; 4464316 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Shariff-Marco, Salma N Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, California KW - Pacific KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Role+of+Perceived+Racism+and+Race-Based+Residential+Segregation+on+Cancer+Behavioral+Risk+Profiles%3A+A+Study+of+Asian+Americans+and+Pacific+Islanders+in+California&rft.au=Shariff-Marco%2C+Salma+N&rft.aulast=Shariff-Marco&rft.aufirst=Salma&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Cancer Education Messages: Reactions of At-Risk African American Men in Washington, D.C T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39205660; 4462479 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Boehm, Karina AU - Daum, Mary AU - Doner, Lynne Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, Washington KW - Africa KW - Ethnic groups KW - Education KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39205660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Oral+Cancer+Education+Messages%3A+Reactions+of+At-Risk+African+American+Men+in+Washington%2C+D.C&rft.au=Boehm%2C+Karina%3BDaum%2C+Mary%3BDoner%2C+Lynne&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Jonathan Mann, HIV/AIDS, and Human Rights T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39204465; 4464193 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Fee, Elizabeth AU - Parry, Manon Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Human immunodeficiency virus KW - Human rights KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Jonathan+Mann%2C+HIV%2FAIDS%2C+and+Human+Rights&rft.au=Fee%2C+Elizabeth%3BParry%2C+Manon&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2006-11-04&rft.volume=15&rft.issue=11&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms. AN - 69022025; 16950780 AB - The C1 domain zinc finger structure is highly conserved among the protein kinase C (PKC) superfamily members. As the interaction site for the second messenger sn-1,2-diacylglycerol (DAG) and for the phorbol esters, the C1 domain has been an important target for developing selective ligands for different PKC isoforms. However, the C1 domains of the atypical PKC members are DAG/phorbol ester-insensitive. Compared with the DAG/phorbol ester-sensitive C1 domains, the rim of the binding cleft of the atypical PKC C1 domains possesses four additional positively charged arginine residues (at positions 7, 10, 11, and 20). In this study, we showed that mutation to arginines of the four corresponding sites in the C1b domain of PKCdelta abolished its high potency for phorbol 12,13-dibutyrate in vitro, with only marginal remaining activity for phorbol 12-myristate 13-acetate in vivo. We also demonstrated both in vitro and in vivo that the loss of potency to ligands was cumulative with the introduction of the arginine residues along the rim of the binding cavity rather than the consequence of loss of a single, specific residue. Computer modeling reveals that these arginine residues reduce access of ligands to the binding cleft and change the electrostatic profile of the C1 domain surface, whereas the basic structure of the binding cleft is still maintained. Finally, mutation of the four arginine residues of the atypical PKC C1 domains to the corresponding residues in the deltaC1b domain conferred response to phorbol ester. We speculate that the arginine residues of the C1 domain of atypical PKCs may provide an opportunity for the design of ligands selective for the atypical PKCs. JF - The Journal of biological chemistry AU - Pu, Yongmei AU - Peach, Megan L AU - Garfield, Susan H AU - Wincovitch, Stephen AU - Marquez, Victor E AU - Blumberg, Peter M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/11/03/ PY - 2006 DA - 2006 Nov 03 SP - 33773 EP - 33788 VL - 281 IS - 44 SN - 0021-9258, 0021-9258 KW - Ions KW - 0 KW - Isoenzymes KW - Ligands KW - Arginine KW - 94ZLA3W45F KW - PKC-3 protein KW - EC 2.7.11.13 KW - Protein Kinase C KW - Index Medicus KW - Isoenzymes -- chemistry KW - Animals KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Computational Biology KW - Protein Binding KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Static Electricity KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Ions -- chemistry KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Protein Transport KW - Cricetinae KW - Protein Kinase C -- metabolism KW - Cell Membrane -- enzymology KW - Arginine -- metabolism KW - Arginine -- genetics KW - Arginine -- chemistry KW - Protein Kinase C -- genetics KW - Protein Kinase C -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69022025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Effects+on+ligand+interaction+and+membrane+translocation+of+the+positively+charged+arginine+residues+situated+along+the+C1+domain+binding+cleft+in+the+atypical+protein+kinase+C+isoforms.&rft.au=Pu%2C+Yongmei%3BPeach%2C+Megan+L%3BGarfield%2C+Susan+H%3BWincovitch%2C+Stephen%3BMarquez%2C+Victor+E%3BBlumberg%2C+Peter+M&rft.aulast=Pu&rft.aufirst=Yongmei&rft.date=2006-11-03&rft.volume=281&rft.issue=44&rft.spage=33773&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Design and Synthesis of a Novel Photoaffinity Ligand for the Dopamine and Serotonin Transporters Based on 2 beta -Carbomethoxy-3 beta -biphenyltropane AN - 19735417; 7543287 AB - Tropane-based photoaffinity ligands covalently bind to discrete points of attachment on the dopamine transporter (DAT). To further explore structure-activity relations, a ligand in which the photoactivated group was extended from the 3-position of the tropane ring was synthesized from cocaine via a Stille or Suzuki coupling strategy. 3-(4'-Azido-3'-iodo-biphenyl-4-yl)-8-methyl-8- aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (11; K sub(i) = 15.1 plus or minus 2.2 nM) demonstrated high binding affinity for the DAT. Moreover, this compound showed moderate binding affinity for the serotonin transporter (SERT, K sub(i) = 109 plus or minus 14 nM), suggesting the potential utility of [ super(125)I]11 in both DAT and SERT protein structure studies. JF - Journal of Medicinal Chemistry AU - Newman, AH AU - Cha, J H AU - Cao, J AU - Kopajtic, T AU - Katz, J L AU - Parnas, M L AU - Vaughan, R AU - Lever, J R AD - Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA Y1 - 2006/11/02/ PY - 2006 DA - 2006 Nov 02 SP - 6621 EP - 6625 VL - 49 IS - 22 SN - 0022-2623, 0022-2623 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Dopamine transporter KW - tropane KW - Serotonin transporter KW - Cocaine KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Gene+expression+patterns+distinguish+colonoscopically+isolated+human+aberrant+crypt+foci+from+normal+colonic+mucosa.&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; tropane; Dopamine transporter; Cocaine; Serotonin transporter DO - http://dx.doi.org/10.1021/jm0603973 ER - TY - JOUR T1 - Temporal bone histopathologic abnormalities associated with mitochondrial mutation T7511C. AN - 85402107; pmid-17075421 AB - We previously reported a mitochondrial T7511C mutation in the tRNA gene in a Japanese family with nonsyndromic hearing loss (HL). However, the temporal bone histopathology associated with T7511C has not been reported. The aim of the present study is to report histopathologic findings of a temporal bone from a patient in the Japanese family with this mutation.Single case study.A temporal bone was obtained from the right ear of a male subject with progressive HL from 5 years of age and who died at 60 years of age from cerebral infarction. The bone was embedded, sectioned, and stained with hematoxylin-eosin for light microscopic study. Graphic reconstruction of the cochlea was performed using the method described by Schuknecht to determine loss of the stria vascularis and neurosensory elements including hair cells and spiral ganglion neurons.The most significant histopathologic finding was severe loss of spiral ganglion cells in all turns of the cochlea. Severe loss of neuronal filaments in Rosenthal's canal was also observed. The organ of Corti showed scattered loss of inner and outer hair cells in the basal turn. Partial atrophy of the stria vascularis was observed in all turns of the cochlea.Our results suggest that severe loss of spiral ganglion cells was the main cause of sensorineural HL associated with the T7511C mutation. JF - The Laryngoscope AU - Ishikawa, Kotaro AU - Tamagawa, Yuya AU - Takahashi, Katsumasa AU - Iino, Yukiko AU - Murakami, Yoshihiko AU - Kakizaki, Keiko AU - Kimura, Hiroshi AU - Kusakari, Jun AU - Hara, Akira AU - Ichimura, Keiichi AD - Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan. ishikawak@nidcd.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1982 EP - 1986 VL - 116 IS - 11 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Atrophy KW - Hearing Loss, Sensorineural: genetics KW - *Hearing Loss, Sensorineural: pathology KW - Humans KW - Male KW - Middle Aged KW - Mitochondria: genetics KW - Mutation KW - Organ of Corti: pathology KW - Spiral Ganglion: cytology KW - Spiral Ganglion: pathology KW - Stria Vascularis: pathology KW - *Temporal Bone: pathology KW - Vestibule, Labyrinth: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Temporal+bone+histopathologic+abnormalities+associated+with+mitochondrial+mutation+T7511C.&rft.au=Ishikawa%2C+Kotaro%3BTamagawa%2C+Yuya%3BTakahashi%2C+Katsumasa%3BIino%2C+Yukiko%3BMurakami%2C+Yoshihiko%3BKakizaki%2C+Keiko%3BKimura%2C+Hiroshi%3BKusakari%2C+Jun%3BHara%2C+Akira%3BIchimura%2C+Keiichi&rft.aulast=Ishikawa&rft.aufirst=Kotaro&rft.date=2006-11-01&rft.volume=116&rft.issue=11&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Characteristic findings of auditory brainstem response and otoacoustic emission in the Bronx waltzer mouse. AN - 85400039; pmid-16730938 AB - Auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs) were evaluated serially from 1 to 22 months in Bronx waltzer homozygotes (bv/bv), heterozygotes (+/bv) and control (+/+) mice, which were differentiated by means of PCR of marker DNA (D5Mit209). The wave IV threshold of the click-evoked ABR was higher than the DPOAE threshold with the DP growth method in each bv/bv, although the two thresholds were almost the same in the +/+ group. The DP value at 2f(1) - f(2) in the bv/bv showed an apparent decrease at 2 to 3 months of age with 80 dB SPL stimulation using f(2) frequency 7996 Hz and frequency ratio f(2)/f(1) = 1.22, compared to control or heterozygote mice. It was characteristic that the 2f(2) - f(1) DP signal-to-noise ratio (SNR) value was more preserved from 80 to 60 dB SPL than the 2f(1) - f(2) DP value at f(2) frequency 7996 Hz in most bv/bv, however, control mice showed almost the same levels of 2f(1) - f(2) and 2f(2) - f(1) SNR value at both f(2) frequencies of 6006 and 7996 Hz. The preservation of a substantial 2f(2) - f(1) DP suggested that it would be generated basal to the primary-tone place on the basilar membrane and there might be a reflection of the unique function of the remaining outer hair cells in the Bronx waltzer mice. These findings suggest that combination of ABR with DPOAE could offer useful information about differentiating the mechanism of hair cell dysfunction of the hereditary hearing impairment in the clinical fields. JF - Brain & development AU - Inagaki, Masumi AU - Kon, Kaori AU - Suzuki, Seiko AU - Kobayashi, Naoko AU - Kaga, Makiko AU - Nanba, Eiji AD - Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawa Higashi, Kodaira 187-8553, Japan. inagaki@ncnp-k.go.jp Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 617 EP - 624 VL - 28 IS - 10 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation: methods KW - Age Factors KW - Animals KW - Animals, Newborn KW - Auditory Threshold: physiology KW - Disease Models, Animal KW - Dose-Response Relationship, Radiation KW - *Evoked Potentials, Auditory, Brain Stem: physiology KW - Female KW - Hearing Disorders: genetics KW - *Hearing Disorders: physiopathology KW - Male KW - Mice KW - Mice, Mutant Strains KW - *Otoacoustic Emissions, Spontaneous KW - RNA, Messenger: biosynthesis KW - Reaction Time: physiology KW - Reverse Transcriptase Polymerase Chain Reaction: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Characteristic+findings+of+auditory+brainstem+response+and+otoacoustic+emission+in+the+Bronx+waltzer+mouse.&rft.au=Inagaki%2C+Masumi%3BKon%2C+Kaori%3BSuzuki%2C+Seiko%3BKobayashi%2C+Naoko%3BKaga%2C+Makiko%3BNanba%2C+Eiji&rft.aulast=Inagaki&rft.aufirst=Masumi&rft.date=2006-11-01&rft.volume=28&rft.issue=10&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. AN - 85397609; pmid-16962269 AB - Jackson circler (jc) is a spontaneous, recessive mouse mutation that results in circling behavior and an impaired acoustic startle response. In this study, we refined the phenotypic and genetic parameters of the original jc mutation and characterized a new mutant allele, jc(2J). In open-field behavior tests, homozygous jc mutants exhibited abnormal circling and ambulatory behavior that was indistinguishable from that of phenotypically similar mutants with defects in the vestibule of the inner ear. The jc/jc and jc(2J)/jc(2J) mice had stable elevated auditory-evoked brainstem response (ABR) thresholds at the 16kHz stimulus of 88+/-9dB sound pressure levels (SPL) and 43+/-11dB SPL, respectively. Peak latencies and peak time intervals were normal in jc mutants. The jc mice showed no measurable distortion-product otoacoustic emissions (DPOAEs) above the system noise floor. In the mutant cochlea, the apical turn failed to form due to the developmental growth arrest of the cochlear duct at the level of the first turn at gestational day 13.5. In a large intrasubspecific intercross, jc localized to a 0.2cM interval at position 25cM on chromosome 10, which is homologous to the human 6q21 region. On CZECHII/Ei and CAST/Ei backgrounds jc/jc mutant hearing thresholds at the 16kHz stimulus were significantly lower than those observed on the C57BL/6J background, with means of 62+/-22dB SPL and 55+/-18dB SPL, respectively. Genome-wide linkage scans of backcross, intercross, and congenic progeny revealed a complex pattern of genetic and stochastic effects. JF - Hearing research AU - Calderon, Alfredo AU - Derr, Adam AU - Stagner, Barden B AU - Johnson, Kenneth R AU - Martin, Glen AU - Noben-Trauth, Konrad AD - Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA. Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 44 EP - 58 VL - 221 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - *Auditory Threshold KW - *Cochlea: abnormalities KW - Crosses, Genetic KW - Evoked Potentials, Auditory, Brain Stem KW - Hyperkinesis: etiology KW - Mice KW - Mice, Inbred C57BL KW - Mice, Mutant Strains KW - Startle Reaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Cochlear+developmental+defect+and+background-dependent+hearing+thresholds+in+the+Jackson+circler+%28jc%29+mutant+mouse.&rft.au=Calderon%2C+Alfredo%3BDerr%2C+Adam%3BStagner%2C+Barden+B%3BJohnson%2C+Kenneth+R%3BMartin%2C+Glen%3BNoben-Trauth%2C+Konrad&rft.aulast=Calderon&rft.aufirst=Alfredo&rft.date=2006-11-01&rft.volume=221&rft.issue=1-2&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Functional outcome of supracricoid partial laryngectomy with cricohyoidopexy: radiation failure vs previously untreated cases. AN - 85395607; pmid-17116818 AB - To evaluate the postoperative course and functional outcomes achieved in patients treated with supracricoid partial laryngectomy (SPL) with cricohyoidopexy.Retrospective analysis.National Cancer Institute "Regina Elena."Eighty-two consecutive patients who underwent SPL with cricohyoidopexy between September 1, 1988, and June 30, 2005, were evaluated. The patient cohort was divided into 2 groups: one affected by untreated laryngeal cancer and the other with laryngeal recurrence after radiotherapy.The postoperative complications and functional outcomes of both patient groups were evaluated and statistically compared.No statistical differences were found between the functional results of the 2 groups of patients analyzed.Although a slightly delayed recovery of physiological functions of the larynx could be termed a disadvantage of SCL with cricohyoidopexy after radiotherapy, this operation is a reliable and useful procedure for selected patients with recurrent cancer who would otherwise have been operated on and received a total laryngectomy. JF - Archives of otolaryngology--head & neck surgery AU - Pellini, Raul AU - Manciocco, Valentina AU - Spriano, Giuseppe AD - Department of Otorhinolaryngology--Head and Neck Surgery, National Cancer Institute "Regina Elena," Rome, Italy. Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1221 EP - 1225 VL - 132 IS - 11 SN - 0886-4470, 0886-4470 KW - National Library of Medicine KW - Adult KW - Aged KW - *Carcinoma, Squamous Cell: surgery KW - *Cricoid Cartilage: surgery KW - Deglutition: physiology KW - Female KW - Humans KW - Laryngeal Neoplasms: radiotherapy KW - *Laryngeal Neoplasms: surgery KW - *Laryngectomy: methods KW - Male KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Phonation: physiology KW - Postoperative Complications KW - Retrospective Studies KW - Salvage Therapy KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Functional+outcome+of+supracricoid+partial+laryngectomy+with+cricohyoidopexy%3A+radiation+failure+vs+previously+untreated+cases.&rft.au=Pellini%2C+Raul%3BManciocco%2C+Valentina%3BSpriano%2C+Giuseppe&rft.aulast=Pellini&rft.aufirst=Raul&rft.date=2006-11-01&rft.volume=132&rft.issue=11&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The importance of gene-environment interactions and exposure assessment in understanding human diseases AN - 807259651; 13653099 JF - Journal of Exposure Science and Environmental Epidemiology AU - Schwartz, David A AD - 1 Director, National Institute of Environmental Health Sciences and National Toxicology Program, PO Box 12233, Research Triangle Park, NC 27709, USA. E-mail: david.schwartz[AT]niehs.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 474 EP - 476 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 6 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Genetics KW - Environmental effects KW - Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807259651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=The+importance+of+gene-environment+interactions+and+exposure+assessment+in+understanding+human+diseases&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=6&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genetics; Environmental effects; Diseases DO - http://dx.doi.org/10.1038/sj.jes.7500531 ER - TY - JOUR T1 - NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). AN - 733098059; 19407857 AB - The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an updated evaluation of the potential for DEHP to cause adverse effects on reproduction and development in humans. The first CERHR expert panel evaluation of DEHP was completed in 2000 by the Phthalates Expert Panel. CERHR selected DEHP for an updated evaluation because of: (1) widespread human exposure, (2) public and government interest in adverse health effects, (3) recently available human exposure studies, and (4) the large number of relevant toxicity papers published since the earlier evaluation. DEHP (CAS RN: 117-81-7) is a high production volume chemical used as a plasticizer of polyvinyl chloride in the manufacture of a wide variety of consumer goods, such as building products, car products, clothing, food packaging, children's products (but not in toys intended for mouthing), and in medical devices made of polyvinyl chloride. The public can be exposed to DEHP by ingesting food, drink or dust that has been in contact with DEHP-containing materials, by inhaling contaminated air or dust, or by undergoing a medical procedure that uses polyvinyl chloride medical tubing or storage bags. It is estimated that the general population of the United States is exposed to DEHP levels ranging from 1 to 30 microg/kg bw/day (micrograms per kilogram body weight per day). The results of this DEHP update evaluation are published in an NTP-CERHR monograph that includes: (1) the NTP Brief, (2) the Expert Panel Update on the Reproductive and Developmental Toxicity of DEHP, and (3) public comments on the expert panel report. The NTP reached the following conclusions on the possible effects of exposure to DEHP on human development and reproduction. Note that the possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and serious concern. There is serious concern that certain intensive medical treatments of male infants may result in DEHP exposure levels that adversely affect development of the male reproductive tract. DEHP exposure from medical procedures in infants was estimated to be as high as 6000 microg/kg bw/day. There is concern for adverse effects on development of the reproductive tract in male offspring of pregnant and breast feeding women undergoing certain medical procedures that may result in exposure to high levels of DEHP. There is concern for effects of DEHP exposure on development of the male reproductive tract for infants less than one year old. Diet, mouthing of DEHP-containing objects, and certain medical treatments may lead to DEHP exposures that are higher than those experienced by the general population. There is some concern for effects of DEHP exposure on development of the reproductive tract of male children older than one year. As in infants, exposures of children to DEHP may be higher than in the general population. There is some concern for adverse effects of DEHP exposure on development of the male reproductive tract in male offspring of pregnant women not medically exposed to DEHP. Although DEHP exposures are assumed to be the same as for the general population, the developing male reproductive tract is sensitive to the adverse effects of DEHP. There is minimal concern for reproductive toxicity in adults exposed to DEHP at 1 - 30 microg/kg bw/day. This level of concern is not altered for adults medically exposed to DEHP. NTP will transmit the NTP-CERHR Monograph on DEHP to federal and state agencies, interested parties, and the public and it will be available in electronic PDF format on the CERHR web site http://cerhr.niehs.nih.gov and in printed text or CD-ROM from the CERHR. JF - NTP CERHR MON AU - Shelby, Michael D AD - NIEHS, Research Triangle Park, NC 27709, USA. shelby@niehs.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - v, vii EP - 7, II-iii-xiii passim IS - 18 SN - 1556-2271, 1556-2271 KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Environmental Exposure KW - Male KW - Female KW - Pregnancy KW - Fetus -- drug effects KW - Reproduction -- drug effects KW - Diethylhexyl Phthalate -- toxicity KW - Diethylhexyl Phthalate -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733098059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NTP+CERHR+MON&rft.atitle=NTP-CERHR+monograph+on+the+potential+human+reproductive+and+developmental+effects+of+di+%282-ethylhexyl%29+phthalate+%28DEHP%29.&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2006-11-01&rft.volume=&rft.issue=18&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=NTP+CERHR+MON&rft.issn=15562271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysis. AN - 69028440; 16980914 AB - Syringe-sharing behaviors among injection drug users (IDUs) are typically based on self-reports and subject to socially desirable responding. We used 3 short tandem repeat (STR) genetic biomarkers to detect sharing in 2,512 syringes exchanged by 315 IDUs in the Baltimore needle exchange program (NEP; 738 person-visits). Demographic characteristics as well as direct and indirect needle-sharing behaviors corresponding to the closest AIDS Link to Intravenous Experience (ALIVE) study visits were examined for association with multiperson use (MPU) of syringes. Overall, 56% of the syringes exchanged at the Baltimore NEP had evidence of MPU. Less MPU of syringes (48% vs. 71%; P < 0.0001) was seen with more rapid syringe turnaround (<3 days). IDUs always exchanging their own syringes ("primary" syringes) were less likely to return syringes with evidence of MPU (52%) than those who exchanged syringes for others ("secondary" syringes; 64%; P = 0.0001) and those exchanging primary and secondary syringes (58%; P = 0.004). In a multivariate analysis restricted to primary exchangers, MPU of syringes was associated with sharing cotton (adjusted odds ratio [AOR] = 2.06, 95% confidence interval [CI]: 1.30 to 3.28), lending syringes (AOR = 1.70, 95% CI: 1.24 to 2.34), and injecting less than daily (AOR = 0.64, 95% CI: 0.43 to 0.95). These findings support additional public health interventions such as expanded syringe access to prevent HIV and other blood-borne infections. Testing of STRs represents a promising approach to examining and accessing complex behavioral data, including syringe sharing. JF - Journal of acquired immune deficiency syndromes (1999) AU - Shrestha, Sadeep AU - Smith, Michael W AU - Broman, Karl W AU - Farzadegan, Homayoon AU - Vlahov, David AU - Strathdee, Steffanie A AD - Laboratory of Genomic Diversity, National Cancer Institute, NCI-Frederick, MD 21702, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 335 EP - 343 VL - 43 IS - 3 SN - 1525-4135, 1525-4135 KW - DNA, Viral KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Prospective Studies KW - Risk-Taking KW - Needle-Exchange Programs -- statistics & numerical data KW - Humans KW - Needle-Exchange Programs -- legislation & jurisprudence KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Algorithms KW - Middle Aged KW - Tandem Repeat Sequences KW - Male KW - Female KW - HIV-1 -- genetics KW - Needle Sharing -- statistics & numerical data KW - HIV Infections -- transmission KW - Syringes -- utilization KW - HIV-1 -- classification KW - DNA, Viral -- analysis KW - HIV Infections -- prevention & control KW - Needle Sharing -- adverse effects KW - Syringes -- adverse effects KW - Substance Abuse, Intravenous -- complications KW - HIV Infections -- epidemiology KW - Syringes -- standards KW - Substance Abuse, Intravenous -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69028440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Multiperson+use+of+syringes+among+injection+drug+users+in+a+needle+exchange+program%3A+a+gene-based+molecular+epidemiologic+analysis.&rft.au=Shrestha%2C+Sadeep%3BSmith%2C+Michael+W%3BBroman%2C+Karl+W%3BFarzadegan%2C+Homayoon%3BVlahov%2C+David%3BStrathdee%2C+Steffanie+A&rft.aulast=Shrestha&rft.aufirst=Sadeep&rft.date=2006-11-01&rft.volume=43&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. AN - 69027566; 16775253 AB - Prostate cancer (PCa) is one of the most common cancers in men. Androgen deprivation therapy (ADT) is employed in the treatment of patients with metastatic or recurrent PCa, resulting in castrate levels of testosterone. Recent studies have shown that male hypogonadism is associated with increased levels of proinflammatory and diminished concentrations of anti-inflammatory cytokines, which normalize upon testosterone treatment. Furthermore, an inflammatory state is associated with osteoporosis, sarcopenia and metabolic abnormalities. We examined 3 groups of men: 1) 20 men with PCa undergoing ADT for at least 12 months prior to the onset of the study (ADT group); 2) 18 age-matched men with non-metastatic PCa who had undergone local surgery and/or radiotherapy and had not yet received ADT and were eugonadal (non-ADT group); and 3) 20 age-matched healthy eugonadal men (control group). None of the subjects were suffering from any acute or chronic inflammatory conditions. Mean age was similar in the 3 groups (P = .41). Men in the ADT and non-ADT groups had higher BMI compared to the control group (P = .0005 and P = .01, respectively). Men in the ADT group had significantly lower mean serum total (P < .0001) and free (P < .0001) testosterone and estradiol (P < .0001) levels compared to the other 2 groups. No significant differences in serum levels of pro-inflammatory or anti-inflammatory cytokines were observed between the 3 groups. These data suggest that men with PCa undergoing long-term ADT do not have elevated levels of pro-inflammatory cytokines compared to age and disease matched controls. Prospective studies are needed to evaluate for any acute changes in these inflammatory markers that might occur after the initiation of ADT. JF - Journal of andrology AU - Maggio, Marcello AU - Blackford, Amanda AU - Taub, Dennis AU - Carducci, Michael AU - Ble, Alessandro AU - Metter, E Jeffrey AU - Braga-Basaria, Milena AU - Dobs, Adrian AU - Basaria, Shehzad AD - Longitudinal Studies Section, Clinical Research Branch and the Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Baltimore, MD, USA. PY - 2006 SP - 725 EP - 728 VL - 27 IS - 6 SN - 0196-3635, 0196-3635 KW - Androgen Antagonists KW - 0 KW - Interleukins KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Hypogonadism -- chemically induced KW - Interleukins -- blood KW - Androgen Antagonists -- therapeutic use KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personnel+Journal+%28pre-1986%29&rft.atitle=Smart+%28and+Legal%29+Maternity%2FPaternity%2FParental+Leave+Policies&rft.au=Howells%2C+Dana+D%3BBrophy%2C+Jonathan+L&rft.aulast=Howells&rft.aufirst=Dana+D&rft.date=2016-03-01&rft.volume=53&rft.issue=3&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Benefits+Magazine&rft.issn=21576157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions. AN - 69025585; 17055706 AB - The interaction between polyenes and azoles is not well understood. We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates (9 itraconazole susceptible and 5 itraconazole resistant) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions: the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories. Synergy was found at combinations with low concentrations of amphotericin B (0.5 mg/L). Synergy was more frequently observed for the itraconazole-resistant isolates than for the itraconazole-susceptible isolates. JF - International journal of antimicrobial agents AU - Meletiadis, Joseph AU - te Dorsthorst, Debbie T A AU - Verweij, Paul E AD - National Cancer Institute, Pediatric Oncology Branch, Bethesda, MD 20892, USA. meletiaj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 439 EP - 449 VL - 28 IS - 5 SN - 0924-8579, 0924-8579 KW - Itraconazole KW - 304NUG5GF4 KW - Amphotericin B KW - 7XU7A7DROE KW - Index Medicus KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Drug Resistance, Fungal KW - Algorithms KW - Drug Synergism KW - Drug Antagonism KW - Microbial Sensitivity Tests KW - Itraconazole -- pharmacology KW - Aspergillus fumigatus -- drug effects KW - Amphotericin B -- pharmacology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=The+concentration-dependent+nature+of+in+vitro+amphotericin+B-itraconazole+interaction+against+Aspergillus+fumigatus%3A+isobolographic+and+response+surface+analysis+of+complex+pharmacodynamic+interactions.&rft.au=Meletiadis%2C+Joseph%3Bte+Dorsthorst%2C+Debbie+T+A%3BVerweij%2C+Paul+E&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=28&rft.issue=5&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-22 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. AN - 69015838; 17075621 AB - The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory. Inhalation and dermal exposure loading were measured simultaneously in 70 subjects on multiple days resulting in 113 observations. Dermal exposure loading was assessed by ACC patches attached to likely exposed skin areas (e.g. the palm of the hand and abdomen). A control patch at the chest and an organic vapor monitor (OVM) were used to adjust the hand and abdomen patches for the contribution from the air through passive absorption of benzene and toluene on the ACC patches. Systemic exposure was assessed by quantification of unmetabolized benzene (UBz) and toluene (UTol) in urine. Mean air concentrations for the study population were 1.5 and 7.5 ppm for benzene and toluene, respectively. Iterative regression analyses between the control patch, OVM and the dermal patches showed that only a small proportion of the ACC patches at the hand had likely benzene (n = 4; mean 133 microg cm(-2) h(-1)) or toluene (n = 5; mean 256 microg cm(-2) h(-1)) contamination. Positive patches were exclusively observed among subjects performing the task of gluing. Significant dermal exposure loading to the abdomen was detected only for toluene (n = 2; mean 235 microg cm(-2) h(-1)). No relation was found between having a positive hand or abdomen ACC patch and UBz or UTol levels. In contrast a strong association was found between air levels of benzene (p = 0.0016) and toluene (p < 0.0001) and their respective urinary levels. ACC patches are shown to be a useful technique for quantifying the probability of dermal exposure to organic solvents and to provide estimates of the potential contribution of the dermal pathway to systemic exposure. Using ACC patches we show that dermal exposure to benzene and toluene in a shoe manufacturing factory is probably rare, and when it occurred exposures were relatively low and did not significantly contribute to systemic exposure. JF - Journal of environmental monitoring : JEM AU - Vermeulen, Roel AU - Lan, Qing AU - Li, Guilan AU - Rappaport, Stephen M AU - Kim, Sungkyoon AU - van Wendel de Joode, Berna AU - Shen, Min AU - Bohong, Xu AU - Smith, Martyn T AU - Zhang, Luoping AU - Yin, Songnian AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA. R.Vermeulen@iras.uu.nl Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1143 EP - 1148 VL - 8 IS - 11 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Charcoal KW - 16291-96-6 KW - Toluene KW - 3FPU23BG52 KW - Benzene KW - J64922108F KW - Index Medicus KW - Inhalation KW - Textiles KW - Humans KW - Abdomen KW - Hand KW - Urine -- chemistry KW - Charcoal -- chemistry KW - Occupational Exposure KW - Skin -- chemistry KW - Benzene -- analysis KW - Air Pollutants, Occupational -- analysis KW - Shoes KW - Toluene -- urine KW - Toluene -- analysis KW - Patch Tests -- methods KW - Air Pollutants, Occupational -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69015838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Assessment+of+dermal+exposure+to+benzene+and+toluene+in+shoe+manufacturing+by+activated+carbon+cloth+patches.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BLi%2C+Guilan%3BRappaport%2C+Stephen+M%3BKim%2C+Sungkyoon%3Bvan+Wendel+de+Joode%2C+Berna%3BShen%2C+Min%3BBohong%2C+Xu%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BYin%2C+Songnian%3BRothman%2C+Nathaniel&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2006-11-01&rft.volume=8&rft.issue=11&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. AN - 69006324; 17000014 AB - Diets rich in vegetables and fruits are associated with reduced risk of several major diseases, including neurodegenerative disorders. Although some beneficial phytochemicals might function solely as antioxidants, it is becoming clear that many of the beneficial chemicals in vegetables and fruits evolved as toxins (to dissuade insects and other predators) that, at subtoxic doses, activate adaptive cellular stress-response pathways in a variety of cells including neurons. Examples of such 'preconditioning' or 'neurohormesis' pathways include those involving cell-survival signaling kinases, the transcription factors NRF2 and CREB, and histone deacetylases of the sirtuin family. In these ways, neurohormetic phytochemicals such as resveratrol, sulforaphanes and curcumin might protect neurons against injury and disease by stimulating the production of antioxidant enzymes, neurotrophic factors, protein chaperones and other proteins that help cells to withstand stress. Thus, as we discuss in this review, highly conserved longevity and survival pathways in neurons are the targets of many phytochemicals. JF - Trends in neurosciences AU - Mattson, Mark P AU - Cheng, Aiwu AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 632 EP - 639 VL - 29 IS - 11 SN - 0166-2236, 0166-2236 KW - Antioxidants KW - 0 KW - Neuroprotective Agents KW - Plant Extracts KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Neuroprotective Agents -- administration & dosage KW - Humans KW - Neuroprotective Agents -- toxicity KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Antioxidants -- toxicity KW - Plant Extracts -- toxicity KW - Neuronal Plasticity -- drug effects KW - Heat-Shock Response -- drug effects KW - Models, Biological KW - Plant Extracts -- administration & dosage KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69006324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+neurosciences&rft.atitle=Neurohormetic+phytochemicals%3A+Low-dose+toxins+that+induce+adaptive+neuronal+stress+responses.&rft.au=Mattson%2C+Mark+P%3BCheng%2C+Aiwu&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2006-11-01&rft.volume=29&rft.issue=11&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Trends+in+neurosciences&rft.issn=01662236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung cancer among nonsmokers. AN - 68999783; 17068413 JF - Epidemiology (Cambridge, Mass.) AU - Blair, Aaron AU - Freeman, Laura Beane AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda 20892, MD, USA. blaira@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 601 EP - 603 VL - 17 IS - 6 SN - 1044-3983, 1044-3983 KW - Index Medicus KW - Risk Factors KW - Humans KW - Male KW - Female KW - Occupational Exposure KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68999783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Lung+cancer+among+nonsmokers.&rft.au=Blair%2C+Aaron%3BFreeman%2C+Laura+Beane&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2006-11-01&rft.volume=17&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 2006 Nov;17(6):615-23 [17068414] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. AN - 68993041; 17058263 AB - Increased oxidative/nitrosative stress is a major contributing factor to alcohol-mediated mitochondrial dysfunction. However, which mitochondrial proteins are oxidatively modified under alcohol-induced oxidative/nitrosative stress is poorly understood. The aim of this study was to systematically investigate oxidized and/or S-nitrosylated mitochondrial proteins and to use a biotin-N-maleimide probe to evaluate their inactivation in alcoholic fatty livers of rats. Binge or chronic alcohol exposure significantly elevated nitric oxide, inducible nitric oxide synthase, and ethanol-inducible CYP2E1. The biotin-N-maleimide-labeled oxidized and/or S-nitrosylated mitochondrial proteins from pair-fed controls or alcohol-fed rat livers were subsequently purified with streptavidin-agarose. The overall patterns of oxidized and/or S-nitrosylated proteins resolved by 2-dimensional polyacrylamide gel electrophoresis were very similar in the chronic and binge alcohol treatment groups. Seventy-nine proteins that displayed differential spot intensities from those of control rats were identified by mass spectrometry. These include mitochondrial aldehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA dehydrogenase, 3-ketoacyl-CoA thiolase, and many proteins involved in chaperone activity, mitochondrial electron transfer, and ion transport. The activity of 3-ketoacyl-CoA thiolase involved in mitochondrial beta-oxidation of fatty acids was significantly inhibited in alcohol-exposed rat livers, consistent with hepatic fat accumulation, as determined by biochemical and histological analyses. Measurement of activity and immunoblot results showed that ALDH2 and ATP synthase were also inhibited through oxidative modification of their cysteine or tyrosine residues in alcoholic fatty livers of rats. In conclusion, our results help to explain the underlying mechanism for mitochondrial dysfunction and increased susceptibility to alcohol-mediated liver damage. JF - Hepatology (Baltimore, Md.) AU - Moon, Kwan-Hoon AU - Hood, Brian L AU - Kim, Bong-Jo AU - Hardwick, James P AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Song, Byoung J AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1218 EP - 1230 VL - 44 IS - 5 SN - 0270-9139, 0270-9139 KW - Central Nervous System Depressants KW - 0 KW - Isoenzymes KW - Maleimides KW - Mitochondrial Proteins KW - Nitrites KW - maleimide KW - 2519R1UGP8 KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Nitrites -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Maleimides -- metabolism KW - Isoenzymes -- metabolism KW - Sequence Analysis, Protein KW - Oxidation-Reduction KW - Rats KW - Rats, Sprague-Dawley KW - Oxidative Stress KW - Nitrosation KW - Nitric Oxide Synthase -- metabolism KW - Male KW - Ethanol -- adverse effects KW - Mitochondria, Liver -- enzymology KW - Central Nervous System Depressants -- adverse effects KW - Fatty Liver, Alcoholic -- metabolism KW - Fatty Liver, Alcoholic -- etiology KW - Mitochondrial Proteins -- metabolism KW - Mitochondrial Proteins -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68993041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Inactivation+of+oxidized+and+S-nitrosylated+mitochondrial+proteins+in+alcoholic+fatty+liver+of+rats.&rft.au=Moon%2C+Kwan-Hoon%3BHood%2C+Brian+L%3BKim%2C+Bong-Jo%3BHardwick%2C+James+P%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BSong%2C+Byoung+J&rft.aulast=Moon&rft.aufirst=Kwan-Hoon&rft.date=2006-11-01&rft.volume=44&rft.issue=5&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. AN - 68983323; 16887932 AB - Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site. In a tubulin assembly system containing microtubule-associated proteins and GTP, however, peloruside A was significantly less active than laulimalide, inducing assembly in a manner that was most similar to sarcodictyins A and B. Because peloruside A thus far seems to be the only compound that mimics the action of laulimalide, we examined combinations of microtubule-stabilizing agents for synergistic effects on tubulin assembly. We found that peloruside A and laulimalide showed no synergism but that both compounds could act synergistically with a number of taxoid site agents [paclitaxel, epothilones A/B, discodermolide, dictyostatin, eleutherobin, the steroid derivative 17beta-acetoxy-2-ethoxy-6-oxo-B-homo-estra-1,3,5(10)-trien-3-ol, and cyclostreptin]. None of the taxoid site compounds showed any synergism with each other. From an initial study with peloruside A and cyclostreptin, we conclude that the synergism phenomenon derives, at least in part, from an apparent lowering of the tubulin critical concentration with drug combinations compared with single drugs. The apparent binding of peloruside A in the laulimalide site led us to attempt construction of a pharmacophore model based on superposition of an energy-minimized structure of peloruside A on the crystal structure of laulimalide. Although the different sizes of the macrocycles limited our ability to superimpose the two molecules, atom correspondences that were observed were consistent with the difficulty so far experienced in creation of fully active analogs of laulimalide. JF - Molecular pharmacology AU - Hamel, Ernest AU - Day, Billy W AU - Miller, John H AU - Jung, M Katherine AU - Northcote, Peter T AU - Ghosh, Arun K AU - Curran, Dennis P AU - Cushman, Mark AU - Nicolaou, K C AU - Paterson, Ian AU - Sorensen, Erik J AD - Toxicology and Pharmacology Branch, Developmental Threapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, MD 21702, USA. hamele@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1555 EP - 1564 VL - 70 IS - 5 SN - 0026-895X, 0026-895X KW - Bridged Bicyclo Compounds, Heterocyclic KW - 0 KW - Lactones KW - Macrolides KW - Microtubule-Associated Proteins KW - Taxoids KW - Tubulin KW - laulimalide KW - peloruside A KW - Glutamic Acid KW - 3KX376GY7L KW - Guanosine Triphosphate KW - 86-01-1 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Microtubule-Associated Proteins -- metabolism KW - Glutamic Acid -- metabolism KW - Tumor Cells, Cultured KW - Models, Molecular KW - Humans KW - Temperature KW - Paclitaxel -- pharmacology KW - Drug Synergism KW - Guanosine Triphosphate -- metabolism KW - Bridged Bicyclo Compounds, Heterocyclic -- chemistry KW - Bridged Bicyclo Compounds, Heterocyclic -- pharmacology KW - Lactones -- chemistry KW - Tubulin -- metabolism KW - Taxoids -- pharmacology KW - Taxoids -- chemistry KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68983323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Synergistic+effects+of+peloruside+A+and+laulimalide+with+taxoid+site+drugs%2C+but+not+with+each+other%2C+on+tubulin+assembly.&rft.au=Hamel%2C+Ernest%3BDay%2C+Billy+W%3BMiller%2C+John+H%3BJung%2C+M+Katherine%3BNorthcote%2C+Peter+T%3BGhosh%2C+Arun+K%3BCurran%2C+Dennis+P%3BCushman%2C+Mark%3BNicolaou%2C+K+C%3BPaterson%2C+Ian%3BSorensen%2C+Erik+J&rft.aulast=Hamel&rft.aufirst=Ernest&rft.date=2006-11-01&rft.volume=70&rft.issue=5&rft.spage=1555&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. AN - 68976753; 17019567 AB - The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question. We assess the reinstatement model in terms of criterion and construct validity. We find that the reinstatement model has adequate criterion validity in the broad sense of the term, as evidenced by the fact that reinstatement in laboratory animals is induced by conditions reported to provoke relapse in humans. The model's criterion validity in the narrower sense, as a medication screen, seems promising for relapse to heroin, nicotine, and alcohol. For relapse to cocaine, criterion validity has not yet been established primarily because clinical studies have examined medication's effects on reductions in cocaine intake rather than relapse during abstinence. The model's construct validity faces more substantial challenges and is yet to be established, but we argue that some of the criticisms of the model in this regard may have been overstated. JF - Psychopharmacology AU - Epstein, David H AU - Preston, Kenzie L AU - Stewart, Jane AU - Shaham, Yavin AD - Clinical Pharmacology and Therapeutics Research Branch, IRP/NIDA/NIH/DHHS, Baltimore, MD 21224, USA. depstein@intra.nida.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1 EP - 16 VL - 189 IS - 1 SN - 0033-3158, 0033-3158 KW - Index Medicus KW - Animals KW - Extinction, Psychological KW - Reproducibility of Results KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Recurrence KW - Cocaine-Related Disorders -- prevention & control KW - Stress, Psychological KW - Motor Activity KW - Conditioning, Operant KW - Cues KW - Heroin Dependence -- prevention & control KW - Tobacco Use Disorder -- psychology KW - Tobacco Use Disorder -- prevention & control KW - Heroin Dependence -- psychology KW - Alcoholism -- prevention & control KW - Models, Animal KW - Behavior, Addictive -- prevention & control KW - Behavior, Addictive -- psychology KW - Substance-Related Disorders -- psychology KW - Behavior, Animal KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68976753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Toward+a+model+of+drug+relapse%3A+an+assessment+of+the+validity+of+the+reinstatement+procedure.&rft.au=Epstein%2C+David+H%3BPreston%2C+Kenzie+L%3BStewart%2C+Jane%3BShaham%2C+Yavin&rft.aulast=Epstein&rft.aufirst=David&rft.date=2006-11-01&rft.volume=189&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited 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[7675970] J Consult Clin Psychol. 1996 Apr;64(2):366-79 [8871421] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. AN - 68975392; 16891616 AB - Microglial activation is implicated in the progressive nature of numerous neurodegenerative diseases, including Parkinson's disease. Using primary rat mesencephalic neuron-glia cultures, we found that pituitary adenylate cyclase-activating polypeptide (PACAP) 38, PACAP27, and its internal peptide, Gly-Ile-Phe (GIF; PACAP4-6), are neuroprotective at 10(-13) M against lipopolysaccharide (LPS)-induced dopaminergic (DA) neurotoxicity, as determined by [(3)H]DA uptake and the number of tyrosine hydroxylase-immunoreactive neurons. PACAP38 and GIF also protected against 1-methyl-4-phenylpyridinium(+)-induced neurotoxicity but only in cultures containing microglia. PACAP38 and GIF ameliorated the production of microglia-derived reactive oxygen species (ROS), where both LPS- and phorbol 12-myristate 13-acetate-induced superoxide and intracellular ROS were inhibited. The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS-induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase (PHOX(-/-)), where PACAP38 and GIF reduced tumor necrosis factor alpha production and were neuroprotective only in PHOX(+/+) cultures and not in PHOX(-/-) cultures. Pretreatment with PACAP6-38 (3 microM; PACAP-specific receptor antagonist) was unable to attenuate PACAP38, PACAP27, or GIF (10(-13) M) neuroprotection. PACAP38 and GIF (10(-13) M) failed to induce cAMP in neuronglia cultures, supporting that the neuroprotective effect was independent of traditional high-affinity PACAP receptors. Pharmacophore analysis revealed that GIF shares common chemical properties (hydrogen bond acceptor, positive ionizable, and hydrophobic regions) with other subpicomolar-acting compounds known to inhibit NADPH oxidase: naloxone, dextromethorphan, and Gly-Gly-Phe. These results indicate a common high-affinity site of action across numerous diverse peptides and compounds, revealing a basic neuropeptide regulatory mechanism that inhibits microglia-derived oxidative stress and promotes neuron survival. JF - The Journal of pharmacology and experimental therapeutics AU - Yang, Sufen AU - Yang, Jun AU - Yang, Zhengqin AU - Chen, Posee AU - Fraser, Alison AU - Zhang, Wei AU - Pang, Hao AU - Gao, Xi AU - Wilson, Belinda AU - Hong, Jau-Shyong AU - Block, Michelle L AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD F1-01, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 595 EP - 603 VL - 319 IS - 2 SN - 0022-3565, 0022-3565 KW - Lipopolysaccharides KW - 0 KW - Neuroprotective Agents KW - Oligopeptides KW - Pituitary Adenylate Cyclase-Activating Polypeptide KW - Cyclic AMP KW - E0399OZS9N KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Rats KW - Cyclic AMP -- biosynthesis KW - Animals KW - Rats, Inbred F344 KW - Lipopolysaccharides -- toxicity KW - Female KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- pharmacology KW - NADPH Oxidase -- antagonists & inhibitors KW - Oxidative Stress -- drug effects KW - Oligopeptides -- pharmacology KW - NADPH Oxidase -- physiology KW - Microglia -- drug effects KW - Neuroprotective Agents -- pharmacology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68975392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Pituitary+adenylate+cyclase-activating+polypeptide+%28PACAP%29+38+and+PACAP4-6+are+neuroprotective+through+inhibition+of+NADPH+oxidase%3A+potent+regulators+of+microglia-mediated+oxidative+stress.&rft.au=Yang%2C+Sufen%3BYang%2C+Jun%3BYang%2C+Zhengqin%3BChen%2C+Posee%3BFraser%2C+Alison%3BZhang%2C+Wei%3BPang%2C+Hao%3BGao%2C+Xi%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Yang&rft.aufirst=Sufen&rft.date=2006-11-01&rft.volume=319&rft.issue=2&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis". AN - 68964751; 16759730 AB - Contemporary phytase research is primarily concerned with ameliorating the problem of inadequate digestion of inositol hexakisphosphate (phytate; InsP6) in monogastric farm animal feed, so as to reduce the pollution that results from the high phosphate content of the manure. In the current study we pursue a new, safe and cost-effective solution. We demonstrate that the rate of hydrolysis of InsP6 by recombinant avian MINPP (0.7 micromol/mg protein/min) defines it as by far the most active phytase found to date in any animal cell (the corresponding activity of recombinant mammalian MINPP is only 0.006 micromol/mg protein/min). Although avian MINPP has less than 20% sequence identity with microbial phytases, we create a homology model of MINPP in which it is predicted that the structure of the phytase active site is well-conserved. This model is validated by site-directed mutagenesis and by use of a substrate analogue, scyllo-InsP6, which we demonstrate is only a weak MINPP substrate. In a model chicken cell line, we overexpressed a mutant form of MINPP that is secretion-competent. This version of the enzyme was actively secreted without affecting either cell viability or the cellular levels of any inositol phosphates. Our studies offer a genetic strategy for greatly improving dietary InsP6 digestion in poultry. JF - Journal of biotechnology AU - Cho, Jaiesoon AU - Choi, Kuicheon AU - Darden, Thomas AU - Reynolds, Paul R AU - Petitte, James N AU - Shears, Stephen B AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, PO Box 12233, NC 27709, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 248 EP - 259 VL - 126 IS - 2 SN - 0168-1656, 0168-1656 KW - Phosphates KW - 0 KW - Phytic Acid KW - 7IGF0S7R8I KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - 6-Phytase KW - EC 3.1.3.26 KW - multiple inositol-polyphosphate phosphatase KW - EC 3.1.3.62 KW - Index Medicus KW - Phosphates -- metabolism KW - Animals KW - Cells, Cultured KW - Male KW - Conservation of Natural Resources KW - 6-Phytase -- metabolism KW - Phytic Acid -- metabolism KW - Protein Engineering -- methods KW - Phosphoric Monoester Hydrolases -- genetics KW - 6-Phytase -- genetics KW - Phosphoric Monoester Hydrolases -- metabolism KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68964751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biotechnology&rft.atitle=Avian+multiple+inositol+polyphosphate+phosphatase+is+an+active+phytase+that+can+be+engineered+to+help+ameliorate+the+planet%27s+%22phosphate+crisis%22.&rft.au=Cho%2C+Jaiesoon%3BChoi%2C+Kuicheon%3BDarden%2C+Thomas%3BReynolds%2C+Paul+R%3BPetitte%2C+James+N%3BShears%2C+Stephen+B&rft.aulast=Cho&rft.aufirst=Jaiesoon&rft.date=2006-11-01&rft.volume=126&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Journal+of+biotechnology&rft.issn=01681656&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-13 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 Sep;20(17):6496-507 [10938126] Biochem Biophys Res Commun. 2000 Aug 28;275(2):279-85 [10964658] Cell Signal. 2001 Mar;13(3):151-8 [11282453] Nat Biotechnol. 2001 May;19(5):415-6 [11329002] Nat Biotechnol. 2001 Aug;19(8):741-5 [11479566] Allergy. 2002 Oct;57(10):943-5 [12269943] Biochem Biophys Res Commun. 2002 Oct 4;297(4):1016-20 [12359257] Poult Sci. 2002 Oct;81(10):1522-32 [12412919] Adv Appl Microbiol. 2000;47:157-99 [12876797] Biochem Biophys Res Commun. 2003 Dec 5;312(1):179-84 [14630039] Biotechnol Lett. 2003 Nov;25(21):1787-94 [14677699] Appl Microbiol Biotechnol. 2004 Jan;63(4):362-72 [14586576] Cancer Res. 1987 Aug 15;47(16):4460-4 [3607775] J Biol Chem. 1991 Sep 5;266(25):16499-506 [1653239] J Biol Chem. 1993 Mar 25;268(9):6161-7 [8384201] J Biol Chem. 1993 Apr 5;268(10):7465-8 [8385108] Adv Appl Microbiol. 1996;42:263-302 [8865587] Nat Struct Biol. 1997 Mar;4(3):185-90 [9164457] Biochem J. 1997 Nov 15;328 ( Pt 1):75-81 [9359836] J Cell Sci. 1998 Mar;111 ( Pt 6):803-13 [9472008] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13597-602 [9811845] FEBS Lett. 1999 Jan 8;442(1):99-104 [9923613] Appl Environ Microbiol. 1999 Feb;65(2):359-66 [9925554] Appl Environ Microbiol. 1999 Feb;65(2):367-73 [9925555] Genomics. 1999 Mar 15;56(3):324-36 [10087200] Science. 1999 Mar 26;283(5410):2015 [10206902] Poult Sci. 1999 May;78(5):674-82 [10228963] Structure. 2004 Nov;12(11):2015-24 [15530366] Biochem Biophys Res Commun. 2005 Mar 11;328(2):404-8 [15694362] J Inorg Biochem. 2005 Mar;99(3):828-40 [15708805] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10002-5 [15972805] Appl Microbiol Biotechnol. 2005 Sep;68(5):588-97 [16041577] Cell Signal. 2006 Apr;18(4):488-98 [15979280] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. AN - 68952426; 16984405 AB - Lipid rafts are membrane microdomains rich in cholesterol and glycosphingolipids that have been implicated in the regulation of intracellular protein trafficking. During exocytosis, a class of proteins termed SNAREs mediate secretory granule-plasma membrane fusion. To investigate the role of lipid rafts in secretory granule exocytosis, we examined the raft association of SNARE proteins and SNARE complexes in rat basophilic leukemia (RBL) mast cells. The SNARE protein SNAP-23 co-localized with a lipid raft marker and was present in detergent-insoluble lipid raft microdomains in RBL cells. By contrast, only small amounts (<20%) of the plasma membrane SNARE syntaxin 4 or the granule-associated SNARE vesicle-associated membrane protein (VAMP)-2 were present in these microdomains. Despite this, essentially all syntaxin 4 and most of VAMP-2 in these rafts were present in SNARE complexes containing SNAP-23, while essentially none of these complexes were present in nonraft membranes. Whereas SNAP-23 is membrane anchored by palmitoylation, the association of the transmembrane protein syntaxin 4 with lipid rafts was because of its binding to SNAP-23. After stimulating mast cells exocytosis, the amount of syntaxin 4 and VAMP-2 present in rafts increased twofold, and these proteins were now present in raft-associated phospho-SNAP-23/syntaxin 4/VAMP-2 complexes, revealing differential association of SNARE fusion complexes during the process of regulated exocytosis. JF - Traffic (Copenhagen, Denmark) AU - Puri, Niti AU - Roche, Paul A AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1482 EP - 1494 VL - 7 IS - 11 SN - 1398-9219, 1398-9219 KW - Dinitrophenols KW - 0 KW - Qa-SNARE Proteins KW - Receptors, IgE KW - SNARE Proteins KW - Serum Albumin, Bovine KW - Snap23 protein, rat KW - Snap25 protein, mouse KW - Synaptosomal-Associated Protein 25 KW - Vesicle-Associated Membrane Protein 2 KW - Vesicular Transport Proteins KW - dinitrophenyl-bovine serum albumin KW - Immunoglobulin E KW - 37341-29-0 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Vesicular Transport Proteins -- genetics KW - Immunoglobulin E -- pharmacology KW - HeLa Cells KW - Humans KW - Dinitrophenols -- immunology KW - Mice KW - Receptors, IgE -- agonists KW - Protein Binding KW - Vesicle-Associated Membrane Protein 2 -- metabolism KW - Phosphorylation -- drug effects KW - Rats KW - Receptors, IgE -- metabolism KW - Qa-SNARE Proteins -- metabolism KW - Immunoglobulin E -- immunology KW - Transfection KW - Synaptosomal-Associated Protein 25 -- metabolism KW - Serum Albumin, Bovine -- immunology KW - Serum Albumin, Bovine -- pharmacology KW - Dinitrophenols -- pharmacology KW - Gangliosidosis, GM1 -- metabolism KW - Synaptosomal-Associated Protein 25 -- genetics KW - Vesicular Transport Proteins -- metabolism KW - Cholera Toxin -- metabolism KW - Exocytosis -- physiology KW - Exocytosis -- drug effects KW - Membrane Microdomains -- metabolism KW - Mast Cells -- metabolism KW - SNARE Proteins -- genetics KW - Mast Cells -- drug effects KW - SNARE Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68952426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+%28Copenhagen%2C+Denmark%29&rft.atitle=Ternary+SNARE+complexes+are+enriched+in+lipid+rafts+during+mast+cell+exocytosis.&rft.au=Puri%2C+Niti%3BRoche%2C+Paul+A&rft.aulast=Puri&rft.aufirst=Niti&rft.date=2006-11-01&rft.volume=7&rft.issue=11&rft.spage=1482&rft.isbn=&rft.btitle=&rft.title=Traffic+%28Copenhagen%2C+Denmark%29&rft.issn=13989219&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cerebellar and other neurological soft signs in antipsychotic-naïve schizophrenia. AN - 68926493; 17022795 AB - Cerebellar neurological abnormalities in schizophrenia have been associated with severe negative symptoms, cognitive deficits, and smaller cerebellar volume. This study assessed the comparative discriminant validity between Cerebellar Soft Signs (CSS) vs. other neurological soft signs (ONSS) [in discriminating between schizophrenia patients and healthy controls] as well as the relationship between the soft signs and psychopathology. Antipsychotic-naïve schizophrenia patients (n = 32) and healthy subjects (n = 32) were examined using International Co-Operative Ataxia Rating Scale and Neurological Evaluation Scale. Mean CSS scores, ONSS total score, and Sensory Integration Signs sub-score were significantly higher in patients. Discriminant analysis revealed two CSS sub-scores (but none of the ONSS scores) to be significant (P < 0.0001) accounting for 78% of classification. CSS total score, Posture sub-score, and Oculomotor sub-score had significant positive correlation with negative syndrome score. Findings support intrinsic cerebellar dysfunction in schizophrenia. The observations are discussed in relationship with cognitive dysmetria. JF - Acta psychiatrica Scandinavica AU - Varambally, S AU - Venkatasubramanian, G AU - Thirthalli, J AU - Janakiramaiah, N AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 352 EP - 356 VL - 114 IS - 5 SN - 0001-690X, 0001-690X KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Dysarthria -- epidemiology KW - Alcoholism -- epidemiology KW - Dysarthria -- diagnosis KW - Humans KW - Adult KW - Posture KW - Neuropsychological Tests KW - Male KW - Female KW - Prevalence KW - Ataxia -- physiopathology KW - Ataxia -- diagnosis KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Schizophrenia -- diagnosis KW - Ataxia -- epidemiology KW - Schizophrenia -- epidemiology KW - Schizophrenia -- physiopathology KW - Cerebellum -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68926493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Cerebellar+and+other+neurological+soft+signs+in+antipsychotic-na%C3%AFve+schizophrenia.&rft.au=Varambally%2C+S%3BVenkatasubramanian%2C+G%3BThirthalli%2C+J%3BJanakiramaiah%2C+N%3BGangadhar%2C+B+N&rft.aulast=Varambally&rft.aufirst=S&rft.date=2006-11-01&rft.volume=114&rft.issue=5&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. AN - 68917612; 17016643 AB - Several years after the isolation of deleted in liver cancer 1 (DLC-1), a gene that encodes a Rho GTPase activating protein, the closely related DLC-2 gene was identified. DLC-1 and DLC-2 are approximately 50% identical and share the same SAM-RhoGAP-START domain organization. Since DLC-1 and -2 are located at chromosome regions that are commonly deleted in cancer cells and have been found to function as tumor suppressor genes, we sought to compare their expression profiles in several common types of cancer and to determine whether dlc1 and dlc2 proteins cooperate in tumor development. Using cancer-profiling arrays, we detected for the first time down-regulation of DLC-1 expression in renal, uterine and rectal cancers and down-regulation of DLC-2 expression in lung, ovarian, renal, breast, uterine, gastric, colon and rectal tumors. Since DLC-1 also functions as a metastasis suppressor gene in breast cancer, DLC-1 and DLC-2 expression were examined in a series of primary ductal carcinomas derived from patients with regional lymph node metastases. Using quantitative RT-PCR we detected a significantly lower expression of DLC-1 and DLC-2 in high percentage of tumors, suggesting that deficiency of either DLC gene facilitates dissemination of breast carcinoma cells to secondary sites. We examined DLC-2 expression in DLC-1-negative cell lines derived from human breast, non-small cell lung, and hepatocellular carcinomas, that could be rendered less or non-tumorigenic by ectopic expression of DLC-1. DLC-2 transcripts were detected in all cell lines, indicating that none of the cells were deficient in both members of the DLC family. This comparative expression analysis of DLC-1 and -2 identifies down-regulation of the two emerging bona fide tumor suppressor genes in additional types of solid tumors. The large spectrum of cancers with dysregulated DLC genes underlines the involvement of this family of genes in cancer development. JF - International journal of oncology AU - Ullmannova, Veronika AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1127 EP - 1132 VL - 29 IS - 5 SN - 1019-6439, 1019-6439 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - STARD13 protein, human KW - Tumor Suppressor Proteins KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cell Line, Tumor KW - Gene Expression Profiling KW - Genes, Tumor Suppressor KW - Tumor Suppressor Proteins -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68917612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Expression+profile+of+the+tumor+suppressor+genes+DLC-1+and+DLC-2+in+solid+tumors.&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicholas+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-11-01&rft.volume=29&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative analysis of in vivo cell proliferation. AN - 68394853; 18428635 AB - Injection and immunohistochemical detection of 5-bromo-2'-deoxyuridine (BrdU) has become the standard method for studying the birth and survival of neurons, glia, and other cell types in the nervous system. BrdU, a thymidine analog, becomes stably incorporated into DNA during the S-phase of mitosis. Because DNA containing BrdU can be specifically recognized by antibodies, this method allows dividing cells to be marked at any given time and then identified at time points from a few minutes to several years later. BrdU immunohistochemistry is suitable for cell counting to examine the regulation of cell proliferation and cell fate. It can be combined with labeling by other antibodies, allowing confocal analysis of cell phenotype or expression of other proteins. The potential for nonspecific labeling and toxicity are discussed. Although BrdU immunohistochemistry has almost completely replaced tritiated thymidine autoradiography for labeling dividing cells, this method and situations in which it is still useful are also described. JF - Current protocols in neuroscience AU - Cameron, Heather A AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 VL - Chapter 3 KW - Antibodies KW - 0 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Antibodies -- immunology KW - Animals KW - Cells, Cultured KW - Cell Count -- methods KW - Cell Culture Techniques -- methods KW - Autoradiography -- methods KW - Biological Assay -- methods KW - Nervous System -- cytology KW - Nervous System -- embryology KW - Nervous System -- growth & development KW - Immunohistochemistry -- methods KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68394853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+neuroscience&rft.atitle=Quantitative+analysis+of+in+vivo+cell+proliferation.&rft.au=Cameron%2C+Heather+A&rft.aulast=Cameron&rft.aufirst=Heather&rft.date=2006-11-01&rft.volume=Chapter+3&rft.issue=&rft.spage=Unit+3.9&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+neuroscience&rft.issn=1934-8576&rft_id=info:doi/10.1002%2FN0471142301.ns0309s37 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-29 N1 - Date created - 2008-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/N0471142301.ns0309s37 ER - TY - JOUR T1 - Hormonal treatment of human hepatocellular carcinoma. AN - 68305213; 17261772 AB - Animal models of experimental liver carcinogenesis and epidemiological studies in humans suggest a relationship between sex hormones and hepatocellular carcinoma (HCC). In 1997, a systematic review of the existing, small randomized trials evaluating the antiestrogen tamoxifen yielded a positive result, but the large randomized CLIP-1 trial showed no survival advantage from the addition of tamoxifen to best supportive care. A possible explanation for the negative results is the lack of patient selection, but the expression of estrogen (ER) and progesterone (PgR) receptors in HCC does not clearly affect the survival outcome of the patients treated with tamoxifen. In the last years, it has been proposed that negative results might be due to the fact that tamoxifen in HCC could act via an ER-independent pathway, which requires much higher doses than those usually administered, but a double-blind Asian randomized trial conducted to assess possible dose-response effect showed no efficacy for tamoxifen, with an inversely negative impact with increasing dose. According to the results of large trials and of the Cochrane systematic review, neither further trials are warranted with tamoxifen in HCC, nor should any use in clinical practice be considered. Interesting results have been obtained when the type of hormonal treatment (tamoxifen or megestrol) has been chosen according to the presence of wild-type or variant ER, but these results should be confirmed in large randomized trials. Negative results have been obtained with antiandrogen therapy. In conclusion, hormonal treatment should not be a part of the current management of HCC patients. JF - Annals of the New York Academy of Sciences AU - Di Maio, Massimo AU - De Maio, Ermelinda AU - Morabito, Alessandro AU - D'Aniello, Roberta AU - De Feo, Gianfranco AU - Gallo, Ciro AU - Perrone, Francesco AD - Clinical Trials Unit, National Cancer Institute, via Mariano Semmola, 80131 Napoli, Italy. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 252 EP - 261 VL - 1089 SN - 0077-8923, 0077-8923 KW - Androgen Antagonists KW - 0 KW - Antineoplastic Agents, Hormonal KW - Estrogen Antagonists KW - Index Medicus KW - Treatment Failure KW - Randomized Controlled Trials as Topic KW - Humans KW - Treatment Outcome KW - Meta-Analysis as Topic KW - Androgen Antagonists -- adverse effects KW - Carcinoma, Hepatocellular -- drug therapy KW - Androgen Antagonists -- therapeutic use KW - Liver Neoplasms -- drug therapy KW - Estrogen Antagonists -- adverse effects KW - Estrogen Antagonists -- therapeutic use KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68305213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Hormonal+treatment+of+human+hepatocellular+carcinoma.&rft.au=Di+Maio%2C+Massimo%3BDe+Maio%2C+Ermelinda%3BMorabito%2C+Alessandro%3BD%27Aniello%2C+Roberta%3BDe+Feo%2C+Gianfranco%3BGallo%2C+Ciro%3BPerrone%2C+Francesco&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2006-11-01&rft.volume=1089&rft.issue=&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implications of recent clinical trials of postmenopausal hormone therapy for management of cardiovascular disease. AN - 68303499; 17261787 AB - Estrogen therapy, originally used for the treatment of menopausal vasomotor symptoms, had by 1990 become a mainstay for the prevention of coronary heart disease (CHD) in postmenopausal women. The recommendations for use of estrogen in CHD were based on epidemiologic, animal, and laboratory data. However, a series of clinical trials published from 1998 onward have failed uniformly to confirm a CHD benefit. When the disappointing results of the secondary prevention trials were announced, there was widespread anticipation of more promising results from the primary prevention trials of the Women's Health Initiative (WHI). The WHI trials in generally healthy women also did not provide evidence of benefit, and the use of HT for disease prevention is now discouraged. In response, some commentators have incorrectly stated that the WHI was not a true primary prevention trial. A more appropriate way to frame the question is whether the effects of HT on cardiovascular disease (CVD) differ by age or years since menopause. Some preliminary data suggest that more recently menopausal women starting HT could be at lower risk of CHD (but not stroke) than women more distant from the menopause. However, even if ongoing studies provide evidence that HT can slow the initiation of early atherosclerosis in younger women, this is unlikely to translate into a reconsideration of the use of HT for the prevention of disease, because the long-term effects on cardiovascular events are unknown and unknowable, HT has other adverse effects, and there are more effective and safer ways of preventing cardiovascular disease. JF - Annals of the New York Academy of Sciences AU - Rossouw, Jacques E AD - Women's Health Initiative, National Heart, Lung, and Blood Institute, Rockledge 2, Room 8106, 6701 Rockledge Drive, Bethesda, MD 20892, USA. rossouwj@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 444 EP - 453 VL - 1089 SN - 0077-8923, 0077-8923 KW - Estrogens KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Female KW - Cardiovascular Diseases -- prevention & control KW - Estrogens -- therapeutic use KW - Coronary Disease -- prevention & control KW - Postmenopause KW - Estrogen Replacement Therapy -- adverse effects KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68303499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Implications+of+recent+clinical+trials+of+postmenopausal+hormone+therapy+for+management+of+cardiovascular+disease.&rft.au=Rossouw%2C+Jacques+E&rft.aulast=Rossouw&rft.aufirst=Jacques&rft.date=2006-11-01&rft.volume=1089&rft.issue=&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting the epigenome for the treatment of thoracic malignancies. AN - 68298066; 17240824 AB - Despite considerable efforts to improve the diagnosis and treatment of lung cancer, this disease remains the leading cause of cancer-related mortality worldwide. Recent elucidation of epigenetic regulation of gene expression during malignant transformation, together with the identification of agents that modulate DNA methylation and histone acetylation, provide new opportunities for the treatment and prevention of lung cancer via chromatin remodeling mechanisms. Further analysis of molecular response in tumor tissues following exposure to chromatin remodeling agents may enable us to identify novel mechanisms pertaining to lung cancer epigenetics, and design more efficacious regimens. JF - Thoracic surgery clinics AU - Schrump, David S AU - Nguyen, Dao M AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Room 4-3940, 10 Center Drive, MSC 1201, Bethesda, MD 20892-1201, USA. david_schrump@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 367 EP - 77, vi VL - 16 IS - 4 SN - 1547-4127, 1547-4127 KW - Antibiotics, Antineoplastic KW - 0 KW - Antimetabolites, Antineoplastic KW - Chromatin KW - Depsipeptides KW - decitabine KW - 776B62CQ27 KW - romidepsin KW - CX3T89XQBK KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Azacitidine -- therapeutic use KW - Chromatin -- metabolism KW - Humans KW - Azacitidine -- analogs & derivatives KW - Depsipeptides -- therapeutic use KW - Antibiotics, Antineoplastic -- therapeutic use KW - Antimetabolites, Antineoplastic -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Depsipeptides -- pharmacology KW - Drug Evaluation, Preclinical KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Cell Transformation, Neoplastic -- genetics KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Epigenesis, Genetic KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68298066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thoracic+surgery+clinics&rft.atitle=Targeting+the+epigenome+for+the+treatment+of+thoracic+malignancies.&rft.au=Schrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Thoracic+surgery+clinics&rft.issn=15474127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Platelet activation, upregulation of CD11b/ CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smoke. AN - 68285029; 17211980 AB - The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta2 Mac-1 integrin (CD11b/CD18) expression on polymorphonuclear leukocytes (PMN) and monocytes, and P-selectin (CD62P) expression on the platelets of 165 women from eastern India, who cook solely with wood, dung and agricultural wastes, and 155 age- and socio-economic condition-matched control subjects, who used relatively cleaner fuel, liquefied petroleum gas (LPG). Leukocyte-platelet aggregates were defined as CD11b-positive PMN and monocytes co-expressing platelet-specific markers CD41 or CD62P. A significant increase in leukocyte-platelet aggregates was found in women who used biomass as cooking fuel. In addition, they showed increased surface expression of CD11b/CD18 in circulating PMN and monocytes and CD62P expression on platelets. The mean fluorescence intensity (MFI) of CD11b on the surface of circulating monocytes and PMN of biomass users increased by 50 and 68%, respectively. Similarly, a 62 and 48% increase in MFI was observed in CD18 expression on the surface of these cells in biomass users. The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis. JF - Human & experimental toxicology AU - Ray, M R AU - Mukherjee, S AU - Roychoudhury, S AU - Bhattacharya, P AU - Banerjee, M AU - Siddique, S AU - Chakraborty, S AU - Lahiri, T AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute, Kolkata 700 026, India. manasrray@rediffmail.com Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 627 EP - 635 VL - 25 IS - 11 SN - 0960-3271, 0960-3271 KW - Antigens, CD11b KW - 0 KW - Antigens, CD18 KW - Manure KW - P-Selectin KW - Particulate Matter KW - Smoke KW - Index Medicus KW - Antigens, CD11b -- biosynthesis KW - Humans KW - Wood KW - Platelet Activation KW - Particulate Matter -- analysis KW - P-Selectin -- biosynthesis KW - Leukocyte Count KW - India KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Adult KW - Plants KW - Particulate Matter -- adverse effects KW - Middle Aged KW - Up-Regulation KW - Female KW - Antigens, CD18 -- biosynthesis KW - Smoke -- adverse effects KW - Blood Platelets -- immunology KW - Neutrophils -- immunology KW - Monocytes -- immunology KW - Cooking KW - Smoke -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68285029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Platelet+activation%2C+upregulation+of+CD11b%2F+CD18+expression+on+leukocytes+and+increase+in+circulating+leukocyte-platelet+aggregates+in+Indian+women+chronically+exposed+to+biomass+smoke.&rft.au=Ray%2C+M+R%3BMukherjee%2C+S%3BRoychoudhury%2C+S%3BBhattacharya%2C+P%3BBanerjee%2C+M%3BSiddique%2C+S%3BChakraborty%2C+S%3BLahiri%2C+T&rft.aulast=Ray&rft.aufirst=M&rft.date=2006-11-01&rft.volume=25&rft.issue=11&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-07 N1 - Date created - 2007-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperthermic isolation limb perfusion with TNFalpha in the treatment of in-transit melanoma metastasis. AN - 68283351; 17203758 AB - Hyperthermic isolation limb perfusion (HILP) with tumor necrosis factor alpha (TNFalpha) and IFNgamma was pioneered by Liénard and Lejeune in 1988. The TNFalpha was empirically employed at a dosage of 3-4 mg, that is ten times the systemic maximum tolerated dose (MTD). After eighteen years from its first clinical application, more than 300 patients have been treated. The aim of this study is to clarify two major arguments: the TNFalpha dose and eligibility criteria for patient selection. A phase I-II study has previously been conducted in 20 patients with in-transit melanoma metastases using a combination of melphalan and TNFalpha at dosages ranging from 0.5 to 3.3 mg. Twenty patients were treated and a complete pathological response of 70% was recorded, with no correlation between tumor response and TNFalpha. The dose of 1 mg of TNFalpha provided the best results regarding efficacy and toxicity. On the basis of this results a large phase II SITILO study was undertaken. Patients with stage IIIA - IIIAB (presence of in transit metastases and/or regional node involvement) were considered eligible; a total of 113 patients were enrolled in the study. The disease was bulky (> 10 nodules or fewer nodules with a diameter > or = 3 cm) in 42.5% of the patients and unresectable in 33%. Forty patients were treated with a TNFalpha dosage > 1 mg and 73 with 1 mg. All the patients were submitted to HILP via axillary and iliac vessels for tumor of upper and lower limb, respectively. TNFalpha was injected in the extracorporal circuit at the pre-established dose, followed after 30 minutes by melphalan (13 and 10 mg/L of limb volume for upper and lower limbs, respectively). A grade 1 and 2 limb toxicity was found in 52.9% and 30.1% of the patients, respectively, 5.5% of patients exhibited a grade 3 and 4, whereas grade 5 limb toxicity was not found. The complete and partial responses were 63% and 24.5%, respectively, with an objective response of 87.5%. We tried to correlate the typed tumor response (CR or not CR) and the TNFalpha dosage 1 mg, but no statistically significant difference was found between the two groups. The bulky disease was the only prognostic factor able to influence the tumor response. Only patients with bulky melanoma disease can benefit from HILP with TNFalpha at a low dose of 1 mg. JF - In vivo (Athens, Greece) AU - Di Filippo, Franco AU - Rossi, Carlo Riccardo AU - Santinami, Mario AU - Cavaliere, Francesco AU - Garinei, Rosa AU - Anzà, Michele AU - Perri, Pasquale AU - Botti, Claudio AU - Di Angelo, Piera AU - Pasqualoni, Rossella AU - Di Filippo, Simona AD - Regina Elena National Cancer Institute, Rome, Italy. difilippo@ifo.it PY - 2006 SP - 739 EP - 742 VL - 20 IS - 6A SN - 0258-851X, 0258-851X KW - Antineoplastic Agents, Alkylating KW - 0 KW - Tumor Necrosis Factor-alpha KW - Melphalan KW - Q41OR9510P KW - Index Medicus KW - Neoplasm Staging KW - Combined Modality Therapy KW - Chemotherapy, Cancer, Regional Perfusion KW - Humans KW - Aged KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Drug Therapy, Combination KW - Extremities KW - Aged, 80 and over KW - Melphalan -- administration & dosage KW - Adult KW - Middle Aged KW - Female KW - Male KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Melanoma -- secondary KW - Hyperthermia, Induced KW - Skin Neoplasms -- therapy KW - Skin Neoplasms -- pathology KW - Melanoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68283351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Hyperthermic+isolation+limb+perfusion+with+TNFalpha+in+the+treatment+of+in-transit+melanoma+metastasis.&rft.au=Di+Filippo%2C+Franco%3BRossi%2C+Carlo+Riccardo%3BSantinami%2C+Mario%3BCavaliere%2C+Francesco%3BGarinei%2C+Rosa%3BAnz%C3%A0%2C+Michele%3BPerri%2C+Pasquale%3BBotti%2C+Claudio%3BDi+Angelo%2C+Piera%3BPasqualoni%2C+Rossella%3BDi+Filippo%2C+Simona&rft.aulast=Di+Filippo&rft.aufirst=Franco&rft.date=2006-11-01&rft.volume=20&rft.issue=6A&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2007-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liposomal doxorubicin with and without TNFalpha in the perfusional treatment of advanced soft tissue limb sarcoma: preliminary results. AN - 68277918; 17203757 AB - A combination of doxorubicin and tumor necrosis factor alpha (TNFalpha) has been proven to be very effective in the perfusional treatment of advanced soft tissue limb sarcoma both in terms of tumor necrosis and limb conservative surgery rate. Unfortunately, in some patients a grade IV limb reaction has been recorded. The key solution might be the use of liposomal doxorubicin (Caelyx) because the carrier seems to release the drug preferentially in the tumor rather than in the healthy tissue. Twenty patients were treated with Caelyx: 14 with Caelyx alone and 6 in combination with a low TNFalpha dose (1 mg). In the first series of 14 patients a dose escalation study was carried out starting from a dose of 10 mg/L of limb volume. Six patients were treated with Caelyx (16 mg) and TNFalpha (1 mg). The maximum tolerated dose (MTD) was 16 mg/L as in two patients treated with 18 mg/L a grade IV limb reaction was observed. Tumor response was satisfactory and conservative surgery was carried out in 13 patients. In 6 patients treated with Caelyx and TNFalpha, only a grade I limb reaction was recorded, thus, confirming that TNFalpha did not increase toxicity, at least at a dose of 1 mg. The Caelyx-TNFalpha combination did increase treatment efficacy. Tumor necrosis > or = 70% was observed in 4 out of 6 patients, one with 100% necrosis (pathological complete response). All the patients underwent conservative surgery. The Caelyx-TNFalpha combination was proven to increase the efficacy of Caelyx alone, with a very low toxicity. These preliminary results have to be tested in a larger patient population. JF - In vivo (Athens, Greece) AU - Di Filippo, Franco AU - Anzà, Michele AU - Garinei, Rosa AU - Cavaliere, Francesco AU - Perri, Pasquale AU - Botti, Claudio AU - Di Angelo, Piera AU - Di Filippo, Simona AU - Maini, Carlo Ludovico AU - Pasqualoni, Rossella AU - Di Segni, Susanna AU - Colantonio, Simona AU - Bruno, Pietro AU - Piarulli, Loredana AU - Principi, Francesca AD - Department of Surgery, Regina Elena National Cancer Institute, Rome, Italy. difilippo@ifo.it PY - 2006 SP - 735 EP - 738 VL - 20 IS - 6A SN - 0258-851X, 0258-851X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Dose-Response Relationship, Drug KW - Combined Modality Therapy KW - Humans KW - Chemotherapy, Cancer, Regional Perfusion KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Male KW - Female KW - Soft Tissue Neoplasms -- pathology KW - Soft Tissue Neoplasms -- drug therapy KW - Sarcoma -- surgery KW - Sarcoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Soft Tissue Neoplasms -- surgery KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68277918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Liposomal+doxorubicin+with+and+without+TNFalpha+in+the+perfusional+treatment+of+advanced+soft+tissue+limb+sarcoma%3A+preliminary+results.&rft.au=Di+Filippo%2C+Franco%3BAnz%C3%A0%2C+Michele%3BGarinei%2C+Rosa%3BCavaliere%2C+Francesco%3BPerri%2C+Pasquale%3BBotti%2C+Claudio%3BDi+Angelo%2C+Piera%3BDi+Filippo%2C+Simona%3BMaini%2C+Carlo+Ludovico%3BPasqualoni%2C+Rossella%3BDi+Segni%2C+Susanna%3BColantonio%2C+Simona%3BBruno%2C+Pietro%3BPiarulli%2C+Loredana%3BPrincipi%2C+Francesca&rft.aulast=Di+Filippo&rft.aufirst=Franco&rft.date=2006-11-01&rft.volume=20&rft.issue=6A&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2007-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. AN - 68258455; 17069536 AB - Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of radiation-damaged salivary glands, we have conducted a detailed toxicity and biodistribution study in adult rats. AdhAQP1 (2x108-2x1011 particles) was delivered to a single submandibular gland by retroductal cannulation. Administration of this vector resulted in no animal mortality or morbidities, and no adverse signs of clinical toxicity. In addition, over the 92-day time course of the study, with both male and female rats, there were no consistent treatment-related changes in serum indicators of hepatic, renal, and cardiac functions. Importantly, we also observed no vector-associated effects on either water consumption by, or hematocrit levels in, study animals. However, three suggestive mild gender-related response differences were seen. Female, but not male, rats exhibited small reductions in food consumption (10-15%) and body weight gain (5-10%), and evidence of persistent inflammation, after vector treatment. These were vector, but not dose, related. Three days after delivery of 2x1011 particles of AdhAQP1, vector was detected primarily in the targeted gland; 9 of 10 samples from the targeted gland were positive, whereas only 5 of 90 nonoral samples were positive. There was no evidence of the generation of replication-competent adenovirus in saliva or blood samples. In aggregate, these findings show that localized delivery of AdhAQP1 to salivary glands appears to occur without significant toxicity. JF - Human gene therapy AU - Zheng, Changyu AU - Goldsmith, Corinne M AU - Mineshiba, Fumi AU - Chiorini, John A AU - Kerr, Andrew AU - Wenk, Martin L AU - Vallant, Molly AU - Irwin, Richard D AU - Baum, Bruce J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1122 EP - 1133 VL - 17 IS - 11 SN - 1043-0342, 1043-0342 KW - Antibodies KW - 0 KW - Aqp1 protein, rat KW - Recombinant Proteins KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Rats KW - Animals KW - Antibodies -- blood KW - Recombinant Proteins -- biosynthesis KW - Transgenes KW - Gene Expression KW - Tissue Distribution KW - Recombinant Proteins -- genetics KW - Male KW - Female KW - Drug Administration Routes KW - Genetic Vectors -- administration & dosage KW - Aquaporin 1 -- genetics KW - Aquaporin 1 -- biosynthesis KW - Submandibular Gland -- drug effects KW - Genetic Vectors -- toxicity KW - Genetic Vectors -- genetics KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68258455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+gene+therapy&rft.atitle=Toxicity+and+biodistribution+of+a+first-generation+recombinant+adenoviral+vector%2C+encoding+aquaporin-1%2C+after+retroductal+delivery+to+a+single+rat+submandibular+gland.&rft.au=Zheng%2C+Changyu%3BGoldsmith%2C+Corinne+M%3BMineshiba%2C+Fumi%3BChiorini%2C+John+A%3BKerr%2C+Andrew%3BWenk%2C+Martin+L%3BVallant%2C+Molly%3BIrwin%2C+Richard+D%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2006-11-01&rft.volume=17&rft.issue=11&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Human+gene+therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. AN - 68177937; 17088436 AB - L-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient asparagine for their own needs. Molecular profiling of the NCI-60 cancer cell lines using five different microarray platforms showed strong negative correlations of asparagine synthetase (ASNS) expression and DNA copy number with sensitivity to l-ASP in the leukemia and ovarian cancer cell subsets. To assess whether the ovarian relationship is causal, we used RNA interference to silence ASNS in three ovarian lines and observed 4- to 5-fold potentiation of sensitivity to l-ASP with two of the lines. For OVCAR-8, the line that expresses the least ASNS, the potentiation was >500-fold. Significantly, that potentiation was >700-fold in the multidrug-resistant derivative OVCAR-8/ADR, showing that the causal relationship between ASNS expression and l-ASP activity survives development of classical multidrug resistance. Tissue microarrays confirmed low ASNS expression in a subset of clinical ovarian cancers as well as other tumor types. Overall, this pharmacogenomic/pharmacoproteomic study suggests the use of l-ASP for treatment of a subset of ovarian cancers (and perhaps other tumor types), with ASNS as a biomarker for patient selection. JF - Molecular cancer therapeutics AU - Lorenzi, Philip L AU - Reinhold, William C AU - Rudelius, Martina AU - Gunsior, Michele AU - Shankavaram, Uma AU - Bussey, Kimberly J AU - Scherf, Uwe AU - Eichler, Gabriel S AU - Martin, Scott E AU - Chin, Koei AU - Gray, Joe W AU - Kohn, Elise C AU - Horak, Ivan D AU - Von Hoff, Daniel D AU - Raffeld, Mark AU - Goldsmith, Paul K AU - Caplen, Natasha J AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Room 5056B, 37 Convent Drive, Bethesda, MD 20892, USA. jw4i@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2613 EP - 2623 VL - 5 IS - 11 SN - 1535-7163, 1535-7163 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - DNA, Neoplasm KW - RNA, Messenger KW - Asparaginase KW - EC 3.5.1.1 KW - Aspartate-Ammonia Ligase KW - EC 6.3.1.1 KW - Index Medicus KW - Gene Expression Profiling KW - RNA, Messenger -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cell Line, Tumor KW - RNA Interference KW - Time Factors KW - DNA, Neoplasm -- metabolism KW - Female KW - Drug Resistance, Multiple KW - Biomarkers, Tumor -- metabolism KW - Aspartate-Ammonia Ligase -- metabolism KW - Aspartate-Ammonia Ligase -- genetics KW - Ovarian Neoplasms -- pathology KW - Asparaginase -- toxicity KW - Antineoplastic Agents -- toxicity KW - Ovarian Neoplasms -- enzymology KW - Asparaginase -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=The+concentration-dependent+nature+of+in+vitro+amphotericin+B-itraconazole+interaction+against+Aspergillus+fumigatus%3A+isobolographic+and+response+surface+analysis+of+complex+pharmacodynamic+interactions.&rft.au=Meletiadis%2C+Joseph%3Bte+Dorsthorst%2C+Debbie+T+A%3BVerweij%2C+Paul+E&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=28&rft.issue=5&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression patterns distinguish colonoscopically isolated human aberrant crypt foci from normal colonic mucosa. AN - 68173185; 17119054 AB - Aberrant crypt foci (ACF) are considered the earliest identifiable preneoplastic colonic lesions; thus, a greater understanding of the nature of genetic changes underlying the transformation of normal colonic mucosa (NM) into ACF may provide insight into the mechanisms of carcinogenesis. ACF were identified by indigo carmine spraying onto colonic mucosa during colonoscopy and isolated as standard pinch biopsies of the mucosal areas containing the ACF. RNAs isolated from ACF and matched NM biopsies from the ascending and descending colons of 13 patients were analyzed on arrays containing 9128 cDNAs. Thirty-four differentially expressed (P < 0.001) genes were found in a paired comparison of the ACF and NM samples, and 25 of 26 matched pairs of ACF and NM could be correctly classified in leave-one-out cross-validation. Differential expression for seven of eight genes was confirmed by real-time reverse transcription-PCR. Furthermore, ACF and NM samples, including six pairs of ACF and NM samples that had not previously been analyzed by array hybridization, can be correctly classified on the basis of the overexpression in ACF of three selected genes (REG4, SRPN-B5, and TRIM29) evaluated by real-time reverse transcription-PCR. In a separate analysis of 13 biopsy pairs from either ascending or descending colon, ACF and NM samples could also be correctly classified by the gene expression patterns. Analysis of gene expression differences in ACF from the ascending and descending colon versus NM samples indicates that ACF from these distinct colonic locations are converging toward similar gene expression profiles and losing differences in gene expression characteristic of NM from the ascending versus descending colon. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Glebov, Oleg K AU - Rodriguez, Luz M AU - Soballe, Peter AU - DeNobile, John AU - Cliatt, Janet AU - Nakahara, Kenneth AU - Kirsch, Ilan R AD - Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2253 EP - 2262 VL - 15 IS - 11 SN - 1055-9965, 1055-9965 KW - DNA, Complementary KW - 0 KW - Index Medicus KW - Colonoscopy KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - DNA, Complementary -- metabolism KW - Adult KW - Aged KW - Middle Aged KW - Biopsy KW - Nucleic Acid Hybridization KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Female KW - Gene Expression Regulation, Neoplastic KW - Colon -- pathology KW - Intestinal Mucosa -- pathology KW - Precancerous Conditions -- diagnosis KW - Gene Expression Regulation KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- diagnosis KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68173185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Gene+expression+patterns+distinguish+colonoscopically+isolated+human+aberrant+crypt+foci+from+normal+colonic+mucosa.&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of second primary cancers. AN - 68169847; 17057028 AB - Due to improvements in early detection, supportive care, and treatment, the number of cancer survivors in the United States has tripled since 1971 and is growing by 2% each year. In 2001, there were approximately 10 million cancer survivors, representing 3.5% of the population. As survival after a diagnosis of cancer improves, quantification of the late effects of cancer and its therapy become critical. One of the most serious events experienced by cancer survivors is the diagnosis of a new cancer. Second- or higher-order cancers now account for approximately 16% of incident cancers reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Subsequent neoplasms may not necessarily be attributable to prior cancer treatment but may also reflect the effect of shared etiologic factors, environmental exposures, host characteristics, and combinations of influences, including gene-environment and gene-gene interactions. This review will focus on selected highlights and recent findings in treatment-associated malignancies, with an emphasis on survivors of adult cancer. Current study methods will also be summarized. Important opportunities for future research include the prospective identification of patient subgroups that might be at heightened susceptibility of developing therapy-associated second cancers to modify planned treatments or select alternative management strategies. For the burgeoning population of cancer survivors treated successfully with past regimens, including those therapies that have been subsequently refined, continued quantification of late effects, including second cancers, remains highly relevant in terms of raising clinician and patient awareness, for informed counseling, and for the development of risk-adapted long-term management strategies. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Executive Plaza South, Suite 7086, Bethesda, MD 20892, USA. duongd@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2020 EP - 2026 VL - 15 IS - 11 SN - 1055-9965, 1055-9965 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Risk KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Neoplasms, Second Primary -- epidemiology KW - Neoplasms, Second Primary -- etiology KW - Neoplasms, Second Primary -- diagnosis KW - Neoplasms -- therapy KW - Neoplasms, Second Primary -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68169847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=The+epidemiology+of+second+primary+cancers.&rft.au=Travis%2C+Lois+B&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia. AN - 68131445; 16950614 AB - Here, we evaluated the relationships between ABCB1 (P-glycoprotein, MDR1) polymorphisms and paclitaxel (Taxol)-induced toxicity and pharmacokinetics. Twenty-six patients were assessable for pharmacogenetics and pharmacokinetics, 22 for neurotoxicity and 18 for myelotoxicity. Patients carrying two reference alleles for the ABCB1 3435C>T polymorphism trended toward a reduced risk to develop neuropathy as compared to patients carrying at least one variant allele (P=0.09). Additionally, patients who were homozygous variant at the 2677 and 3435 loci had a significantly greater percent decrease in absolute neutrophil count at nadir (P=0.02). Neither polymorphism correlated with paclitaxel pharmacokinetics. This pilot study suggests that paclitaxel-induced neuropathy and neutropenia might be linked to inherited variants of ABCB1 through a mechanism that is unrelated to altered plasma pharmacokinetics. JF - European journal of cancer (Oxford, England : 1990) AU - Sissung, Tristan M AU - Mross, Klaus AU - Steinberg, Seth M AU - Behringer, Dirk AU - Figg, William D AU - Sparreboom, Alex AU - Mielke, Stephan AD - Clinical Pharmacology Research Core, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2893 EP - 2896 VL - 42 IS - 17 SN - 0959-8049, 0959-8049 KW - ABCB1 protein, human KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Organic Anion Transporters KW - P-Glycoprotein KW - P-Glycoproteins KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Genotype KW - Humans KW - Organic Anion Transporters -- genetics KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Polymorphism, Genetic -- genetics KW - Peripheral Nervous System Diseases -- genetics KW - Neutropenia -- chemically induced KW - Neutropenia -- genetics KW - Peripheral Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68131445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Association+of+ABCB1+genotypes+with+paclitaxel-mediated+peripheral+neuropathy+and+neutropenia.&rft.au=Sissung%2C+Tristan+M%3BMross%2C+Klaus%3BSteinberg%2C+Seth+M%3BBehringer%2C+Dirk%3BFigg%2C+William+D%3BSparreboom%2C+Alex%3BMielke%2C+Stephan&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2006-11-01&rft.volume=42&rft.issue=17&rft.spage=2893&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=09598049&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacokinet. 2004;43(9):553-76 [15217301] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] Blood. 1992 Dec 1;80(11):2729-34 [1360266] Cell. 1994 May 20;77(4):491-502 [7910522] Drug Metab Dispos. 1998 Apr;26(4):343-6 [9531522] Pharmacogenet Genomics. 2005 Oct;15(10):693-704 [16141795] J Clin Pharmacol. 2006 Mar;46(3):373-9 [16490813] Anticancer Drugs. 2003 Nov;14(10):785-92 [14597872] J Clin Oncol. 2002 Jan 15;20(2):574-81 [11786588] Pharmacogenetics. 2001 Jun;11(4):293-8 [11434506] Br J Cancer. 2001 Jan 5;84(1):42-7 [11139311] Recent Results Cancer Res. 1998;144:93-115 [9304712] Proc Natl Acad Sci U S A. 1989 Jan;86(2):695-8 [2563168] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality associated with fenbendazole administration in pigeons (Columba livia). AN - 68130083; 17089995 AB - A group of 12 domestic pigeons (Columba livia domestica) was treated for capillariasis by use of fenbendazole at 30 mg/kg orally once daily for 5 d. After treatment, 8 of the 12 pigeons exhibited signs of anorexia, lethargy, and dehydration; these birds died within 2 d after the onset of clinical signs. A total of 6 birds were necropsied, and all had unremarkable gross findings. Microscopic examination of tissues revealed acute hemorrhagic enteritis, diffuse lymphoplasmacytic enteritis, small intestinal crypt necrosis, periportal lymphoplasmacytic hepatitis, bile duct hyperplasia, and renal tubular necrosis. Erythrocytes in blood samples collected from surviving birds demonstrated polychromasia compatible with a regenerative anemia. The clinical and histopathologic findings in these pigeons were consistent with recent reports of fenbendazole toxicity in domestic pigeons and other columbiform birds. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Gozalo, Alfonso S AU - Schwiebert, Rebecca S AU - Lawson, Gregory W AD - Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. gozaloa@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 63 EP - 66 VL - 45 IS - 6 SN - 1559-6109, 1559-6109 KW - Antinematodal Agents KW - 0 KW - Fenbendazole KW - 621BVT9M36 KW - Index Medicus KW - Mortality KW - Animals KW - Liver -- pathology KW - Kidney -- pathology KW - Liver -- drug effects KW - Kidney -- drug effects KW - Intestine, Small -- drug effects KW - Capillaria -- physiology KW - Intestine, Small -- pathology KW - Antinematodal Agents -- administration & dosage KW - Fenbendazole -- adverse effects KW - Fenbendazole -- therapeutic use KW - Antinematodal Agents -- therapeutic use KW - Antinematodal Agents -- adverse effects KW - Fenbendazole -- administration & dosage KW - Columbidae -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68130083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Mortality+associated+with+fenbendazole+administration+in+pigeons+%28Columba+livia%29.&rft.au=Gozalo%2C+Alfonso+S%3BSchwiebert%2C+Rebecca+S%3BLawson%2C+Gregory+W&rft.aulast=Gozalo&rft.aufirst=Alfonso&rft.date=2006-11-01&rft.volume=45&rft.issue=6&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Subjective unmet need for mental health services in depressed children grown up. AN - 68129213; 16823630 AB - Limited attention has been devoted to characterizing unmet need for treatment among individuals with mental disorders. A longitudinal follow-up of depressed, anxious, and psychiatrically normal children into adulthood provided an opportunity to examine factors associated with subjective unmet need. Respondents (n = 208) comprise a subsample of a cohort ascertained between 1977 and 1985 consisting of three subgroups: one with major depressive disorder (MDD), one with anxiety disorders but no MDD, and controls with no psychiatric disorder up to ascertainment. Psychiatric status was reassessed in adulthood using the SADS-LA by interviewers blind to childhood diagnoses. Best-estimate diagnoses describing participants' lifetime clinical course were formulated by senior clinicians. Participants who completed SADS-LA interviews about themselves were invited to complete an additional interview about experiences with health care, including subjective unmet need for and barriers to mental health treatment. About 37% of respondents reported lifetime histories of subjective unmet need for mental health services. Unmet need was associated with female gender and lifetime mood and substance dependence disorders. The most commonly cited barriers included attitudes toward treatment, not knowing where to obtain it, and financial concerns. Subjective unmet need was common in this sample. Approaches to reducing it might include public health initiatives to foster more favorable attitudes toward treatment, increase knowledge of where to obtain it, and lower financial barriers. JF - Administration and policy in mental health AU - Goldstein, Risë B AU - Olfson, Mark AU - Martens, Elaine Goff AU - Wolk, Susan I AD - Division of Clinical-Genetic Epidemiology, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA. goldster@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 666 EP - 673 VL - 33 IS - 6 SN - 0894-587X, 0894-587X KW - Index Medicus KW - Socioeconomic Factors KW - New York KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Interviews as Topic KW - Follow-Up Studies KW - Child KW - Adolescent KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Anxiety Disorders -- therapy KW - Mental Health Services -- utilization KW - Depressive Disorder, Major -- therapy KW - Needs Assessment KW - Mental Health Services -- organization & administration KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68129213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Phase+II+trial+of+PN401%2C+5-FU%2C+and+leucovorin+in+unresectable+or+metastatic+adenocarcinoma+of+the+stomach%3A+A+Southwest+Oncology+Group+study&rft.au=Doroshow%2C+James+H%3BMcCoy%2C+Sheryl%3BMacdonald%2C+John+S%3BIssell%2C+Brian+F%3BPatel%2C+Taral%3BCobb%2C+Patrick+W%3BYost%2C+Kathleen+J%3BAbbruzzese%2C+James+L&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2006-11-01&rft.volume=24&rft.issue=6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-006-9244-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2006-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. AN - 68128364; 17093175 AB - A meta-analysis of 19 trials suggested a small increase in the risk of all-cause mortality with high-dose vitamin E supplementation. Little is known, however, about the relation between mortality and circulating concentrations of vitamin E resulting from dietary intake, low-dose supplementation, or both. We examined whether baseline serum alpha-tocopherol concentrations are associated with total and cause-specific mortality. A prospective cohort study of 29 092 Finnish male smokers aged 50-69 y who participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study was carried out. Fasting serum alpha-tocopherol was measured at baseline by using HPLC. Only 10% of participants reported vitamin E supplement use at baseline, and thus serum concentrations of vitamin E mainly reflected dietary intake and other host factors. Risks of total and cause-specific mortality were estimated by using proportional hazards models. During up to 19 y of follow-up, 13 380 deaths (including 4518 and 5776 due to cancer and cardiovascular disease, respectively) were identified. Men in the higher quintiles of serum alpha-tocopherol had significantly lower risks of total and cause-specific mortality than did those in the lowest quintile [relative risk (RR) = 0.82 (95% CI: 0.78, 0.86) for total mortality and 0.79 (0.72, 0.86), 0.81 (0.75, 0.88), and 0.70 (0.63, 0.79) for deaths due to cancer, cardiovascular disease, and other causes, respectively; P for trend for all < 0.0001]. Cubic regression spline analysis of continuous serum alpha-tocopherol values indicated greater risk reductions with increasing concentrations up to approximately 13-14 mg/L, after which no further benefit was noted. Higher circulating concentrations of alpha-tocopherol within the normal range are associated with significantly lower total and cause-specific mortality in older male smokers. JF - The American journal of clinical nutrition AU - Wright, Margaret E AU - Lawson, Karla A AU - Weinstein, Stephanie J AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch and the Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. wrighmar@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1200 EP - 1207 VL - 84 IS - 5 SN - 0002-9165, 0002-9165 KW - Vitamin E KW - 1406-18-4 KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Abridged Index Medicus KW - Index Medicus KW - Mortality KW - Odds Ratio KW - alpha-Tocopherol -- blood KW - Dose-Response Relationship, Drug KW - Finland KW - Humans KW - Aged KW - Fasting KW - Cause of Death KW - Smoking KW - Prospective Studies KW - Cohort Studies KW - Chromatography, High Pressure Liquid -- methods KW - Confidence Intervals KW - Middle Aged KW - Dietary Supplements KW - Follow-Up Studies KW - Meta-Analysis as Topic KW - Male KW - Proportional Hazards Models KW - Cardiovascular Diseases -- mortality KW - Neoplasms -- mortality KW - Cardiovascular Diseases -- epidemiology KW - Cardiovascular Diseases -- blood KW - Neoplasms -- blood KW - Neoplasms -- epidemiology KW - Vitamin E -- adverse effects KW - Diet KW - Vitamin E -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68128364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Higher+baseline+serum+concentrations+of+vitamin+E+are+associated+with+lower+total+and+cause-specific+mortality+in+the+Alpha-Tocopherol%2C+Beta-Carotene+Cancer+Prevention+Study.&rft.au=Wright%2C+Margaret+E%3BLawson%2C+Karla+A%3BWeinstein%2C+Stephanie+J%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Wright&rft.aufirst=Margaret&rft.date=2006-11-01&rft.volume=84&rft.issue=5&rft.spage=1200&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-14 N1 - Date created - 2006-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Clin Nutr. 2006 Nov;84(5):959-60 [17093143] Am J Clin Nutr. 2007 Jul;86(1):261-2; author reply 262-4 [17616790] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology. AN - 68122527; 16971652 AB - We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (P(Trend) < 0.0005) and histologic diagnoses (P(Trend) < 0.0005). JF - Journal of clinical microbiology AU - Castle, Philip E AU - Sadorra, Mark AU - Garcia, Francisco AU - Holladay, E Blair AU - Kornegay, Janet AD - Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 3915 EP - 3917 VL - 44 IS - 11 SN - 0095-1137, 0095-1137 KW - Index Medicus KW - Genotype KW - Cytodiagnosis KW - Humans KW - Cervical Intraepithelial Neoplasia -- virology KW - Pilot Projects KW - Female KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- pathology KW - Papillomaviridae -- classification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68122527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Pilot+study+of+a+commercialized+human+papillomavirus+%28HPV%29+genotyping+assay%3A+comparison+of+HPV+risk+group+to+cytology+and+histology.&rft.au=Castle%2C+Philip+E%3BSadorra%2C+Mark%3BGarcia%2C+Francisco%3BHolladay%2C+E+Blair%3BKornegay%2C+Janet&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2006-11-01&rft.volume=44&rft.issue=11&rft.spage=3915&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Lancet. 2005 Sep 17-23;366(9490):991-8 [16168781] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Br J Cancer. 2006 Jan 16;94(1):171-5 [16404371] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1394-9 [12433717] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Obstet Gynecol. 1992 Mar;79(3):328-37 [1310805] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Int J Cancer. 2005 Nov 1;117(2):177-81 [15900579] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation. AN - 68113894; 17085308 AB - The primary objective of this clinical trial was to evaluate the safety, feasibility, and biologic effects of administering costimulated, interleukin (IL)-4 polarized donor CD4(+) T cells in the setting of HLA-matched sibling, T cell-replete allogeneic hematopoietic cell transplantation (HCT). Forty-seven subjects with hematologic malignancy received granulocyte colony-stimulating factor-mobilized allogeneic hematopoietic cell transplants and cyclosporine graft-versus-host disease (GVHD) prophylaxis after reduced intensity conditioning. Initial subjects received no additional cells (n = 19); subsequent subjects received additional donor CD4(+) T cells generated ex vivo by CD3/CD28 costimulation in medium containing IL-4 and IL-2 (administered day 1 after HCT at 5, 25, or 125 x 10(6) cells/kg). Studies after HCT included measurement of monocyte IL-1alpha and tumor necrosis factor alpha, detection of T cells with antitumor specificity, and characterization of T cell cytokine phenotype. The culture method generated donor CD4(+) T cells that secreted increased T helper 2 (Th2) cytokines and decreased T helper 1 (Th1) cytokines. Such Th2-like cells were administered without infusional or dose-limiting toxicity. The Th2 cohort had accelerated lymphocyte reconstitution; both cohorts had rapid hematopoietic recovery and alloengraftment. Acute GVHD and overall survival were similar in the Th2 and non-Th2 cohorts. Th2 cell recipients tended to have increased monocyte IL-1alpha and had increased tumor necrosis factor alpha secretion. CD8(+) T cells with antitumor specificity were observed in Th2 and non-Th2 cohorts. Post-transplantation T cells from Th2 cell recipients secreted IL-4 and IL-10 (Th2 cytokines) and IL-2 and interferon gamma (Th1 cytokines). Allograft augmentation with costimulated, IL-4-polarized donor CD4(+) T cells resulted in activated Th1, Th2, and inflammatory cytokine pathways without an apparent increase in GVHD. JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Fowler, Daniel H AU - Odom, Jeanne AU - Steinberg, Seth M AU - Chow, Catherine K AU - Foley, Jason AU - Kogan, Yelena AU - Hou, Jeannie AU - Gea-Banacloche, Juan AU - Sportes, Claude AU - Pavletic, Steven AU - Leitman, Susan AU - Read, Elizabeth J AU - Carter, Charles AU - Kolstad, Arne AU - Fox, Rebecca AU - Beatty, Gregory L AU - Vonderheide, Robert H AU - Levine, Bruce L AU - June, Carl H AU - Gress, Ronald E AU - Bishop, Michael R AD - Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA. dhfowler@helix.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1150 EP - 1160 VL - 12 IS - 11 SN - 1083-8791, 1083-8791 KW - Cytokines KW - 0 KW - IL4 protein, human KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Hematologic Neoplasms -- therapy KW - Humans KW - Adult KW - Aged KW - Transplantation, Homologous -- methods KW - Middle Aged KW - Cytokines -- metabolism KW - Male KW - Female KW - Interleukin-4 -- immunology KW - Interleukin-4 -- pharmacology KW - Th2 Cells -- drug effects KW - CD4-Positive T-Lymphocytes -- immunology KW - Th2 Cells -- transplantation KW - CD4-Positive T-Lymphocytes -- transplantation KW - Graft vs Host Disease -- prevention & control KW - Th2 Cells -- immunology KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68113894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Phase+I+clinical+trial+of+costimulated%2C+IL-4+polarized+donor+CD4%2B+T+cells+as+augmentation+of+allogeneic+hematopoietic+cell+transplantation.&rft.au=Fowler%2C+Daniel+H%3BOdom%2C+Jeanne%3BSteinberg%2C+Seth+M%3BChow%2C+Catherine+K%3BFoley%2C+Jason%3BKogan%2C+Yelena%3BHou%2C+Jeannie%3BGea-Banacloche%2C+Juan%3BSportes%2C+Claude%3BPavletic%2C+Steven%3BLeitman%2C+Susan%3BRead%2C+Elizabeth+J%3BCarter%2C+Charles%3BKolstad%2C+Arne%3BFox%2C+Rebecca%3BBeatty%2C+Gregory+L%3BVonderheide%2C+Robert+H%3BLevine%2C+Bruce+L%3BJune%2C+Carl+H%3BGress%2C+Ronald+E%3BBishop%2C+Michael+R&rft.aulast=Fowler&rft.aufirst=Daniel&rft.date=2006-11-01&rft.volume=12&rft.issue=11&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=10838791&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-23 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. AN - 68112294; 17085670 AB - Loss of p53 function impairs apoptosis induced by DNA-damaging agents used for cancer therapy. Here, we examined the effect of the heat shock protein 90 (HSP90) inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG) on doxorubicin-induced apoptosis in lymphoma. We aimed to establish the optimal schedule for administration of both drugs in combination and the molecular basis for their interaction. Isogenic lymphoblastoid and nonisogenic lymphoma cell lines differing in p53 status were exposed to each drug or combination. Drug effects were examined using Annexin V, active caspase-3, cell cycle, and cytotoxicity assays. Synergy was evaluated by median effect/combination index. Protein expression and kinase inhibition provided insight into the molecular mechanisms of drug interaction. Presence of mutant p53 conferred increased survival to single agents. Nevertheless, DMAG showed synergistic toxicity with doxorubicin independently of p53 status. Synergy required exposure to doxorubicin before DMAG. DMAG-mediated down-regulation of CHK1, a known HSP90 client, forced doxorubicin-treated cells into premature mitosis followed by apoptosis. A CHK1 inhibitor, SB-218078, reproduced the effect of DMAG. Administration of DMAG before doxorubicin resulted in G1-S arrest and protection from apoptosis, leading to additive or antagonistic interactions that were exacerbated by p53 mutation. Administration of DMAG to doxorubicin-primed cells induced premature mitosis and had a synergistic effect on apoptosis regardless of p53 status. These observations provide a rationale for prospective clinical trials and stress the need to consider schedule of exposure as a critical determinant of the overall response when DMAG is combined with chemotherapeutic agents for the treatment of patients with relapsed/refractory disease. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Robles, Ana I AU - Wright, Mollie H AU - Gandhi, Bheru AU - Feis, Steven S AU - Hanigan, Christin L AU - Wiestner, Adrian AU - Varticovski, Lyuba AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute and Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA. roblesa@mail.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 6547 EP - 6556 VL - 12 IS - 21 SN - 1078-0432, 1078-0432 KW - Benzoquinones KW - 0 KW - HSP90 Heat-Shock Proteins KW - Lactams, Macrocyclic KW - Tumor Suppressor Protein p53 KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Immunoblotting KW - Drug Administration Schedule KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Apoptosis -- drug effects KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Cell Line, Tumor KW - Drug Synergism KW - Mutation KW - Cell Cycle -- drug effects KW - Doxorubicin -- pharmacology KW - Benzoquinones -- pharmacology KW - Lymphoma -- drug therapy KW - Lactams, Macrocyclic -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Tumor Suppressor Protein p53 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68112294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Schedule-dependent+synergy+between+the+heat+shock+protein+90+inhibitor+17-%28dimethylaminoethylamino%29-17-demethoxygeldanamycin+and+doxorubicin+restores+apoptosis+to+p53-mutant+lymphoma+cell+lines.&rft.au=Robles%2C+Ana+I%3BWright%2C+Mollie+H%3BGandhi%2C+Bheru%3BFeis%2C+Steven+S%3BHanigan%2C+Christin+L%3BWiestner%2C+Adrian%3BVarticovski%2C+Lyuba&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2006-11-01&rft.volume=12&rft.issue=21&rft.spage=6547&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. AN - 68110277; 17079483 AB - Human primary intraocular lymphoma (PIOL) is predominantly a B cell-originated malignant disease with no appropriate animal models and effective therapies available. This study aimed to establish a mouse model to closely mimic human B-cell PIOL and to test the therapeutic potential of a recently developed immunotoxin targeting human B-cell lymphomas. Human B-cell lymphoma cells were intravitreally injected into severe combined immunodeficient mice. The resemblance of this tumor model to human PIOL was examined by fundoscopy, histopathology, immunohistochemistry, and evaluated for molecular markers. The therapeutic effectiveness of immunotoxin HA22 was tested by injecting the drug intravitreally. Results showed that the murine model resembles human PIOL closely. Pathologic examination revealed that the tumor cells initially colonized on the retinal surface, followed by infiltrating through the retinal layers, expanding preferentially in the subretinal space, and eventually penetrating through the retinal pigment epithelium into the choroid. Several putative molecular markers for human PIOL were expressed in vivo in this model. Tumor metastasis into the central nervous system was also observed. A single intravitreal injection of immunotoxin HA22 after the establishment of the PIOL resulted in complete regression of the tumor. This is the first report of a murine model that closely mimics human B-cell PIOL. This model may be a valuable tool in understanding the molecular pathogenesis of human PIOL and for the evaluation of new therapeutic approaches. The results of B cell-specific immunotoxin therapy may have clinical implications in treating human PIOL. JF - Cancer research AU - Li, Zhuqing AU - Mahesh, Sankaranarayana P AU - Shen, De Fen AU - Liu, Baoying AU - Siu, Willie O AU - Hwang, Frank S AU - Wang, Qing-Chen AU - Chan, Chi-Chao AU - Pastan, Ira AU - Nussenblatt, Robert B AD - Laboratory of Immunology, National Eye Institute and Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10586 EP - 10593 VL - 66 IS - 21 SN - 0008-5472, 0008-5472 KW - CD22 protein, human KW - 0 KW - CXCR5 protein, human KW - Immunotoxins KW - Receptors, CXCR4 KW - Receptors, CXCR5 KW - Receptors, Chemokine KW - Sialic Acid Binding Ig-like Lectin 2 KW - Index Medicus KW - Receptors, Chemokine -- analysis KW - Neoplasm Invasiveness KW - Animals KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Mice, SCID KW - Sialic Acid Binding Ig-like Lectin 2 -- analysis KW - Receptors, CXCR4 -- analysis KW - Eye Neoplasms -- therapy KW - B-Lymphocytes -- drug effects KW - Lymphoma, B-Cell -- therapy KW - Lymphoma, B-Cell -- immunology KW - Lymphoma, B-Cell -- pathology KW - Immunotoxins -- therapeutic use KW - Eye Neoplasms -- pathology KW - Eye Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Eradication+of+tumor+colonization+and+invasion+by+a+B+cell-specific+immunotoxin+in+a+murine+model+for+human+primary+intraocular+lymphoma.&rft.au=Li%2C+Zhuqing%3BMahesh%2C+Sankaranarayana+P%3BShen%2C+De+Fen%3BLiu%2C+Baoying%3BSiu%2C+Willie+O%3BHwang%2C+Frank+S%3BWang%2C+Qing-Chen%3BChan%2C+Chi-Chao%3BPastan%2C+Ira%3BNussenblatt%2C+Robert+B&rft.aulast=Li&rft.aufirst=Zhuqing&rft.date=2006-11-01&rft.volume=66&rft.issue=21&rft.spage=10586&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1997 Jun 15;79(12):2409-13 [9191531] Arch Ophthalmol. 1997 Sep;115(9):1157-60 [9298057] Clin Cancer Res. 2005 Feb 15;11(4):1545-50 [15746059] J Neuroophthalmol. 2005 Mar;25(1):33-6 [15756131] Hematol Oncol Clin North Am. 2005 Aug;19(4):739-49, viii [16083834] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] Curr Opin Oncol. 2001 May;13(3):137-42 [11307054] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Vision Res. 2002 Feb;42(4):487-95 [11853765] Curr Mol Med. 2001 May;1(2):259-72 [11899075] J Leukoc Biol. 2002 Jul;72(1):1-8 [12101256] Cancer. 2002 Jul 1;95(1):193-202 [12115333] Curr Opin Ophthalmol. 2002 Dec;13(6):411-8 [12441846] Blood. 2003 Feb 1;101(3):815-21 [12393412] Ophthalmology. 2003 Feb;110(2):421-6 [12578791] Methods Mol Biol. 2004;248:503-18 [14970517] Trans Am Ophthalmol Soc. 2003;101:275-92 [14971583] Ocul Immunol Inflamm. 2004 Mar;12(1):7-16 [15209459] J Leukoc Biol. 2004 Aug;76(2):462-71 [15155773] Can J Ophthalmol. 1986 Jun;21(4):144-9 [3755372] Ophthalmology. 1988 May;95(5):625-30 [3050698] Cancer. 1988 Dec 1;62(11):2461-5 [3179963] Science. 1991 Nov 22;254(5035):1173-7 [1683495] Cancer. 1993 Aug 1;72(3):843-9 [8334638] Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2462-3 [10476821] Ophthalmology. 1999 Sep;106(9):1805-10 [10485554] Clin Cancer Res. 1999 Sep;5(9):2311-5 [10499598] Graefes Arch Clin Exp Ophthalmol. 2004 Nov;242(11):901-13 [15565454] Curr Oncol Rep. 2005 Jan;7(1):74-9 [15610690] Invest Ophthalmol Vis Sci. 2005 Feb;46(2):415-9 [15671263] J Biol Chem. 1994 Jul 15;269(28):18327-31 [7913461] Recent Results Cancer Res. 1994;135:155-69 [8047690] J Natl Cancer Inst. 1996 May 15;88(10):675-9 [8627644] Br J Ophthalmol. 1997 Jan;81(1):31-6 [9135405] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression. AN - 68110048; 17039256 AB - Overexpression of pituitary tumor-transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma (TRbeta(PV/PV) mice). Here we examined the molecular mechanisms underlying elevated PTTG1 levels and the contribution of increased PTTG1 to thyroid carcinogenesis. We showed that PTTG1 was physically associated with thyroid hormone beta receptor (TRbeta) as well as its mutant, designated PV. Concomitant with thyroid hormone-induced (T3-induced) degradation of TRbeta, PTTG1 proteins were degraded by the proteasomal machinery, but no such degradation occurred when PTTG1 was associated with PV. The degradation of PTTG1/TRbeta was activated by the direct interaction of the liganded TRbeta with steroid receptor coactivator 3 (SRC-3), which recruits proteasome activator PA28gamma. PV, which does not bind T3, could not interact directly with SRC-3/PA28gamma to activate proteasome degradation, resulting in elevated PTTG1 levels. The accumulated PTTG1 impeded mitotic progression in cells expressing PV. Our results unveil what we believe to be a novel mechanism by which PTTG1, an oncogene, is regulated by the liganded TRbeta. The loss of this regulatory function in PV led to an aberrant accumulation of PTTG1 disrupting mitotic progression that could contribute to thyroid carcinogenesis. JF - The Journal of clinical investigation AU - Ying, Hao AU - Furuya, Fumihiko AU - Zhao, Li AU - Araki, Osamu AU - West, Brian L AU - Hanover, John A AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2972 EP - 2984 VL - 116 IS - 11 SN - 0021-9738, 0021-9738 KW - Ligands KW - 0 KW - Neoplasm Proteins KW - RNA, Small Interfering KW - Securin KW - Thyroid Hormone Receptors beta KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Mice KW - RNA, Small Interfering -- genetics KW - Mice, Transgenic KW - Protein Binding KW - Proteasome Endopeptidase Complex -- metabolism KW - Mutation -- genetics KW - Thyroid Neoplasms -- pathology KW - Cell Line KW - Cell Transformation, Neoplastic -- genetics KW - Thyroid Hormone Receptors beta -- metabolism KW - Mitosis KW - Neoplasm Proteins -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Functional+Compensation+for+Adipose+Differentiation-related+Protein+%28ADFP%29+by+Tip47+in+an+ADFP+Null+Embryonic+Cell+Line&rft.au=Sztalryd%2C+Carole%3BBell%2C+Ming%3BLu%2C+Xinyue%3BMertz%2C+Pamela%3BHickenbottom%2C+Sabrina%3BChang%2C+Benny+H-J%3BChan%2C+Lawrence%3BKimmel%2C+Alan+R%3BLondos%2C+Constantine&rft.aulast=Sztalryd&rft.aufirst=Carole&rft.date=2006-11-01&rft.volume=281&rft.issue=45&rft.spage=34341&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2000 Jan 20;19(3):403-9 [10656688] Cell. 2006 Jan 27;124(2):381-92 [16439211] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8985-90 [10908671] Mol Endocrinol. 2000 Aug;14(8):1137-46 [10935539] J Biol Chem. 2000 Nov 24;275(47):36502-5 [11013229] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Brain Pathol. 2001 Jul;11(3):328-41 [11414475] Mol Cell Biol. 2001 Oct;21(20):6782-95 [11564863] J Clin Endocrinol Metab. 2001 Oct;86(10):5025-32 [11600580] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] Thyroid. 2002 Nov;12(11):963-9 [12490073] Genes Chromosomes Cancer. 2003 Mar;36(3):292-302 [12557229] Cancer Genet Cytogenet. 2003 Feb;141(1):26-31 [12581895] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Clin Otolaryngol Allied Sci. 2003 Oct;28(5):386-95 [12969338] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Endocrinology. 2003 Nov;144(11):4991-8 [12960092] Methods Enzymol. 2003;364:257-84 [14631850] Arch Biochem Biophys. 2004 May 15;425(2):158-64 [15111123] J Biol Chem. 2004 Aug 6;279(32):33909-18 [15166217] Mol Endocrinol. 1991 Apr;5(4):485-92 [1922081] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7737-41 [1502193] J Clin Invest. 1993 Oct;92(4):1986-93 [8408652] Biochemistry. 1995 Aug 22;34(33):10591-9 [7544615] Mol Endocrinol. 1997 Apr;11(4):433-41 [9092795] Genes Chromosomes Cancer. 1997 May;19(1):43-51 [9135994] Cell. 1998 Apr 3;93(1):81-91 [9546394] Oncogene. 1998 Oct 29;17(17):2187-93 [9811450] J Clin Endocrinol Metab. 1999 Feb;84(2):761-7 [10022450] Science. 1999 Jul 16;285(5426):418-22 [10411507] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Trends Biochem Sci. 2005 Mar;30(3):126-32 [15752984] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] Oncogene. 2005 Jul 14;24(30):4861-6 [15897900] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Cancer Treat Res. 2004;122:85-105 [16209039] Lancet. 2000 Feb 26;355(9205):716-9 [10703804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. AN - 68107071; 17021608 AB - Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We aimed to discover biomarkers in urinary exosomes to detect acute kidney injury (AKI), which has a high mortality and morbidity. Animals were injected with cisplatin. Urinary exosomes were isolated by differential centrifugation. Protein changes were evaluated by two-dimensional difference in gel electrophoresis and changed proteins were identified by mass spectrometry. The identified candidate biomarkers were validated by Western blotting in individual urine samples from rats subjected to cisplatin injection; bilateral ischemia and reperfusion (I/R); volume depletion; and intensive care unit (ICU) patients with and without AKI. We identified 18 proteins that were increased and nine proteins that were decreased 8 h after cisplatin injection. Most of the candidates could not be validated by Western blotting. However, exosomal Fetuin-A increased 52.5-fold at day 2 (1 day before serum creatinine increase and tubule damage) and remained elevated 51.5-fold at day 5 (peak renal injury) after cisplatin injection. By immunoelectron microscopy and elution studies, Fetuin-A was located inside urinary exosomes. Urinary Fetuin-A was increased 31.6-fold in the early phase (2-8 h) of I/R, but not in prerenal azotemia. Urinary exosomal Fetuin-A also increased in three ICU patients with AKI compared to the patients without AKI. We conclude that (1) proteomic analysis of urinary exosomes can provide biomarker candidates for the diagnosis of AKI and (2) urinary Fetuin-A might be a predictive biomarker of structural renal injury. JF - Kidney international AU - Zhou, H AU - Pisitkun, T AU - Aponte, A AU - Yuen, P S T AU - Hoffert, J D AU - Yasuda, H AU - Hu, X AU - Chawla, L AU - Shen, R-F AU - Knepper, M A AU - Star, R A AD - Renal Diagnostics and Therapeutics Unit, NIDDK, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1847 EP - 1857 VL - 70 IS - 10 SN - 0085-2538, 0085-2538 KW - AHSG protein, human KW - 0 KW - Antineoplastic Agents KW - Biomarkers KW - Blood Proteins KW - alpha-2-HS-Glycoprotein KW - alpha-Fetoproteins KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Models, Animal KW - Animals KW - Kidney -- pathology KW - alpha-Fetoproteins -- urine KW - Humans KW - Kidney -- drug effects KW - Aged KW - Biomarkers -- urine KW - Antineoplastic Agents -- adverse effects KW - Rats KW - Aged, 80 and over KW - Kidney -- injuries KW - Adult KW - Cisplatin -- pharmacology KW - Middle Aged KW - Cell Membrane -- metabolism KW - Cisplatin -- adverse effects KW - Antineoplastic Agents -- pharmacology KW - Male KW - Female KW - Reperfusion Injury -- etiology KW - Proteomics -- methods KW - Acute Kidney Injury -- pathology KW - Blood Proteins -- urine KW - Acute Kidney Injury -- etiology KW - Reperfusion Injury -- urine KW - Reperfusion Injury -- pathology KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Exosomal+Fetuin-A+identified+by+proteomics%3A+a+novel+urinary+biomarker+for+detecting+acute+kidney+injury.&rft.au=Zhou%2C+H%3BPisitkun%2C+T%3BAponte%2C+A%3BYuen%2C+P+S+T%3BHoffert%2C+J+D%3BYasuda%2C+H%3BHu%2C+X%3BChawla%2C+L%3BShen%2C+R-F%3BKnepper%2C+M+A%3BStar%2C+R+A&rft.aulast=Zhou&rft.aufirst=H&rft.date=2006-11-01&rft.volume=70&rft.issue=10&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-08 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: N Engl J Med. 1996 May 30;334(22):1448-60 [8618585] Am J Physiol. 1996 Sep;271(3 Pt 2):F477-88 [8853409] Am J Kidney Dis. 1997 May;29(5):793-9 [9159318] Anat Embryol (Berl). 1998 Feb;197(2):125-33 [9497155] Kidney Int. 1998 Dec;54(6):1817-31 [9853246] Am J Transplant. 2005 Apr;5(4 Pt 1):729-38 [15760396] Proteomics. 2005 Mar;5(4):1033-42 [15669002] J Clin Invest. 2005 Mar;115(3):610-21 [15711640] Lancet. 2005 Apr 2-8;365(9466):1231-8 [15811456] Kidney Int. 2005 Jun;67(6):2159-67 [15882259] Nephrology (Carlton). 2005 Jun;10(3):283-90 [15958043] Ther Apher Dial. 2005 Jun;9(3):208-10 [15966990] Clin Chim Acta. 2005 Jul 24;357(2):151-8 [15896729] J Am Soc Nephrol. 2005 Oct;16(10):2920-30 [16093453] J Am Soc Nephrol. 2005 Oct;16(10):3046-52 [16148039] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] Diabetes Care. 2006 Feb;29(2):468 [16443916] Nephrol Dial Transplant. 2006 Mar;21(3):616-23 [16384831] Am J Pathol. 1992 Apr;140(4):831-8 [1562048] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73 [15326289] Am J Nephrol. 2004 May-Jun;24(3):307-15 [15148457] Clin Chem. 2004 Mar;50(3):552-8 [14709451] Am J Kidney Dis. 2004 Mar;43(3):405-14 [14981598] Diabetes Care. 2006 Apr;29(4):853-7 [16567827] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Am J Physiol Renal Physiol. 2004 Jan;286(1):F170-9 [12965894] Nephron Exp Nephrol. 2003;95(2):e69-78 [14610326] J Am Soc Nephrol. 2003 Oct;14(10):2534-43 [14514731] Am J Kidney Dis. 2003 Sep;42(3):497-506 [12955677] J Clin Invest. 2003 Aug;112(3):357-66 [12897203] Lancet. 2003 Mar 8;361(9360):827-33 [12642050] Clin Biochem. 2002 Nov;35(8):581-9 [12498991] Kidney Int. 2002 Nov;62(5):1601-10 [12371960] Kidney Int. 2002 Oct;62(4):1461-9 [12234320] Am J Physiol Renal Physiol. 2006 May;290(5):F1187-93 [16368740] Kidney Int. 2006 Apr;69(8):1471-6 [16501490] Proc Natl Acad Sci U S A. 2006 May 2;103(18):7159-64 [16641100] Kidney Int. 2006 Jul;70(1):199-203 [16710348] Kidney Int. 2006 Aug;70(3):496-506 [16760904] J Lab Clin Med. 1999 Dec;134(6):649-58 [10595794] Blood Purif. 2001;19(2):233-7 [11150816] Shock. 2001 Mar;15(3):181-5 [11236900] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Household Work Complexity, Intellectual Functioning, and Self-Esteem in Men and Women AN - 61677945; 200717434 AB - Using data from a U.S. longitudinal investigation of psychological effects of occupational conditions (a project of the National Institute of Mental Health's unit on Socioenvironmental Studies), we examined the relationship between the complexity of household work & 2 psychological variables: intellectual flexibility & self-esteem. Longitudinal reciprocal effects analyses revealed that for men (n = 351) & women (n = 355), more complex household work was associated with increased intellectual flexibility. For women, complex household work was also associated with increased self-confidence & decreased self-deprecation. For men, complex household work was associated with decreased self-confidence. The results are discussed in terms of theories of the cognitive & neurological effects of environmental complexity & of theories of self-esteem. Tables, Figures, References. Adapted from the source document. JF - Journal of Marriage and Family AU - Caplan, Leslie J AU - Schooler, Carmi AD - Section Socioenvironmental Studies, National Instit Mental Health, Bethesda, MD leslie.caplan@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 883 EP - 900 PB - Blackwell Publishers, Malden MA VL - 68 IS - 4 SN - 0022-2445, 0022-2445 KW - family roles, housework/division of labor, personality, self-esteem KW - Self Esteem KW - Housework KW - Working Women KW - Working Men KW - Flexibility KW - Sex Differences KW - Cognitive Functioning KW - Home Environment KW - Sexual Division of Labor KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61677945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+Family&rft.atitle=Household+Work+Complexity%2C+Intellectual+Functioning%2C+and+Self-Esteem+in+Men+and+Women&rft.au=Caplan%2C+Leslie+J%3BSchooler%2C+Carmi&rft.aulast=Caplan&rft.aufirst=Leslie&rft.date=2006-11-01&rft.volume=68&rft.issue=4&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+Family&rft.issn=00222445&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-02 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Housework; Self Esteem; Working Men; Working Women; Sexual Division of Labor; Sex Differences; Cognitive Functioning; Flexibility; Home Environment ER - TY - JOUR T1 - Childhood onset schizophrenia: cortical brain abnormalities as young adults AN - 57197201; 200713078 AB - Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient-control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naive and medicated adult onset patients. Tables, Figures. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry and Allied Disciplines AU - Greenstein, Deanna AU - Lerch, Jason AU - Shaw, Philip AU - Clasen, Liv AU - Giedd, Jay AU - Gochman, Peter AU - Rapoport, Judith AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH/NIH, Bethesda, MD Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1003 EP - 1012 PB - Blackwell Publishing, Oxford UK VL - 47 IS - 10 SN - 0021-9630, 0021-9630 KW - Childhood onset schizophrenia KW - MRI KW - cortical thickness KW - development KW - neurodevelopment KW - schizophrenia KW - Schizophrenia KW - Neurodevelopmental aspects KW - Prospective studies KW - Magnetic resonance imaging KW - Comparative research KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57197201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.atitle=Childhood+onset+schizophrenia%3A+cortical+brain+abnormalities+as+young+adults&rft.au=Greenstein%2C+Deanna%3BLerch%2C+Jason%3BShaw%2C+Philip%3BClasen%2C+Liv%3BGiedd%2C+Jay%3BGochman%2C+Peter%3BRapoport%2C+Judith%3BGogtay%2C+Nitin&rft.aulast=Greenstein&rft.aufirst=Deanna&rft.date=2006-11-01&rft.volume=47&rft.issue=10&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2006.01658.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Schizophrenia; Childhood onset; Comparative research; Magnetic resonance imaging; Neurodevelopmental aspects; Prospective studies DO - http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x ER - TY - JOUR T1 - Leptin As a Marker of Body Fat and Hyperinsulinemia in College Students AN - 57139368; 200705264 AB - Little is known about obesity & insulin resistance in college students. Leptin is a hormone secreted by fat cells & has been shown to strongly correlate with both obesity & insulin resistance in children & adults. We investigated associations of leptin with insulin secretion & action in 119 normal-weight students aged 18-24 years. Leptin was strongly correlated with total fat mass (r = .67, p < .001), percentage body fat (r = .81, p < .001), & to a lesser degree Body Mass Index, or BMI, (r = .23, p < .02). Leptin was associated with fasting insulin (b - SE = 0.30 - 0.06, p < .001) & insulin resistance (b - SE = 0.41 - 0.20, p < .001) independent of total fat, gender, & age, suggesting other mechanisms of leptin & insulin regulation besides obesity. Leptin resistance is present even among young & normal-weight college students. Leptin, even more so than BMI, is an important marker of adiposity & hyperinsulinemia in normal-weight college students & may potentially be used to predict type 2 diabetes. Tables, References. Adapted from the source document. JF - Journal of American College Health AU - Kempf, Angela M AU - Strother, Myra L AU - Li, Chaoyang AU - Kaur, Harsohena AU - Huang, Terry T.-K. AD - c/o Huang -- Endocrinology/Nutrition/Growth Branch, Center Research Mothers & Children, National Instit Child Health & Human Development, Rockville, MD Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 175 EP - 180 PB - Heldref Publications, Washington DC VL - 55 IS - 3 SN - 0744-8481, 0744-8481 KW - insulin resistance, insulin secretion, leptin, obesity KW - Obesity KW - Resistance KW - Body fat KW - Insulin KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57139368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+American+College+Health&rft.atitle=Leptin+As+a+Marker+of+Body+Fat+and+Hyperinsulinemia+in+College+Students&rft.au=Kempf%2C+Angela+M%3BStrother%2C+Myra+L%3BLi%2C+Chaoyang%3BKaur%2C+Harsohena%3BHuang%2C+Terry+T.-K.&rft.aulast=Kempf&rft.aufirst=Angela&rft.date=2006-11-01&rft.volume=55&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+American+College+Health&rft.issn=07448481&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Undergraduate students; Insulin; Obesity; Body fat; Resistance ER - TY - JOUR T1 - Changes in Genetic and Environmental Influences on Depressive Symptoms across Adolescence and Young Adulthood AN - 57110724; 200704092 AB - Background: Depression rises markedly in adolescence, a time when increased & new genetic influences have been reported. Aims: To examine 'new' & 'stable' genetic & environmental factors on depressive symptoms in adolescence & young adulthood. Method: Aquestionnaire survey investigated a sample of twin & sibling pairs at three time points over an approximately 3-year period. Over 1800 twin & sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models. Results: Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave 1 genetic factors accounted for continuity of symptoms at waves 2 & 3. 'New' genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point. Conclusions: New genetic & environmental influences may explain age-related increases in depression across development. Tables, Figures, References. Adapted from the source document. JF - The British Journal of Psychiatry AU - Lau, Jennifer Y F AU - Eley, Thalia C AD - National Instit Health, Bethesda, MD lauj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 422 EP - 427 PB - Royal College of Psychiatrists, London UK VL - 189 SN - 0007-1250, 0007-1250 KW - Genetic factors KW - Depression KW - Environmental aspects KW - Familial factors KW - Young adults KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Changes+in+Genetic+and+Environmental+Influences+on+Depressive+Symptoms+across+Adolescence+and+Young+Adulthood&rft.au=Lau%2C+Jennifer+Y+F%3BEley%2C+Thalia+C&rft.aulast=Lau&rft.aufirst=Jennifer+Y&rft.date=2006-11-01&rft.volume=189&rft.issue=&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.105.018721 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Adolescents; Young adults; Depression; Genetic factors; Familial factors; Environmental aspects DO - http://dx.doi.org/10.1192/bjp.bp.105.018721 ER - TY - JOUR T1 - Association of Executive Function and Performance of Dual-Task Physical Tests among Older Adults: Analyses from the InChianti Study AN - 57110055; 200703769 AB - Background: previous studies have reported an association between cognitive function & physical performance, particularly among older adults. Objective: to examine the association between executive function & performance difference on complex versus usual walking tasks in a sample of non-demented older adults. Design: population-based epidemiological study of older people residing in the Chianti area (Tuscany, Italy). Participants: 737 community-dwelling individuals aged 65 years & older. Methods: gait speed (m/s) was measured during the performance of complex walking tasks (walking/talking, walking/picking-up an object, walking/carrying a large package, walking over obstacles, walking with a weighted vest) & reference walking tasks (7 m usual pace, 7 m fast pace & 60 m fast pace). Executive function was assessed using the Trail Making Test (TMT). Other measures included Mini-Mental State Examination (MMSE), sociodemographic characteristics & selected physiological impairments. Results: gait speed for the selected reference & complex walk tasks was consistently lower among participants with poor executive function. Per cent decline in gait speed compared with the reference task differed by executive function for certain tasks (e.g. walking/obstacles: 30 versus 24% decline in low versus high executive function respectively, P = 0.0006) but not for others. Conclusions: poor executive function is associated with measures of gait, including specific challenges. Overall, the results showed that the cost associated with the addition of a challenge to the basic walking task differs by executive function & the nature of the task. Further research is needed to determine whether improvement in executive function abilities translates to better performance on selected complex walking tasks. Tables, References. Adapted from the source document. JF - Age and Ageing AU - Coppin, Antonia K AU - Shumway-Cook, Anne AU - Saczynski, Jane S AU - Patel, Kushang V AU - Ble, Alessandro AU - Ferrucci, Luigi AU - Guralnik, Jack M AD - National Instit Aging, National Instit Health, Bethesda, MD coppina@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 619 EP - 624 PB - Oxford University Press, UK VL - 35 IS - 6 SN - 0002-0729, 0002-0729 KW - executive function, older adults, physical performance KW - dual tasks KW - mobility KW - elderly KW - Elderly people KW - Mobility KW - Physical activity KW - Gait KW - Walking speed KW - Executive function KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Age+and+Ageing&rft.atitle=Association+of+Executive+Function+and+Performance+of+Dual-Task+Physical+Tests+among+Older+Adults%3A+Analyses+from+the+InChianti+Study&rft.au=Coppin%2C+Antonia+K%3BShumway-Cook%2C+Anne%3BSaczynski%2C+Jane+S%3BPatel%2C+Kushang+V%3BBle%2C+Alessandro%3BFerrucci%2C+Luigi%3BGuralnik%2C+Jack+M&rft.aulast=Coppin&rft.aufirst=Antonia&rft.date=2006-11-01&rft.volume=35&rft.issue=6&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Age+and+Ageing&rft.issn=00020729&rft_id=info:doi/10.1093%2Fageing%2Fafl107 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Elderly people; Walking speed; Gait; Mobility; Physical activity; Executive function DO - http://dx.doi.org/10.1093/ageing/afl107 ER - TY - JOUR T1 - Possible Selves and Proximal Goals for the Academy AN - 57092803; 200703249 AB - This article features the 2006 Presidential inaugural address presented at the American Academy of Health Behavior Annual Meeting by Bruce Simons-Morton. Dr. Simons-Morton proposes several organizational goals for the Academy. Tables. Adapted from the source document. JF - American Journal of Health Behavior AU - Simons-Morton, Bruce AD - Prevention Research Branch, Division Statistics/Epidemiology/Prevention Research, National Instit Child Heal mortonb@nail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 598 EP - 601 PB - PNG Publications, Star City WV VL - 30 IS - 6 SN - 1087-3244, 1087-3244 KW - Goals KW - Professional associations KW - Conferences KW - Speeches KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=Possible+Selves+and+Proximal+Goals+for+the+Academy&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2006-11-01&rft.volume=30&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Conferences; Health behaviour; Professional associations; Speeches; Goals ER - TY - JOUR T1 - Decision Making about Children with Psychotic Symptoms: Using the Best Evidence in Choosing a Treatment AN - 57088081; 200703229 AB - This article examines the decision making involved to treat children diagnosed with psychosis & childhood schizophrenia. Tables, References. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Shaw, Philip AU - Rapoport, Judith L AD - Child Psychiatry Branch, National Instit Mental Health, Bethesda, MD shawp@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1381 EP - 1386 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 45 IS - 11 SN - 0890-8567, 0890-8567 KW - Schizophrenia KW - Clinical decision making KW - Childhood KW - Child psychotherapy KW - Psychoses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57088081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Decision+Making+about+Children+with+Psychotic+Symptoms%3A+Using+the+Best+Evidence+in+Choosing+a+Treatment&rft.au=Shaw%2C+Philip%3BRapoport%2C+Judith+L&rft.aulast=Shaw&rft.aufirst=Philip&rft.date=2006-11-01&rft.volume=45&rft.issue=11&rft.spage=1381&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2F01.chi.0000233780.53785.a4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinical decision making; Psychoses; Child psychotherapy; Schizophrenia; Childhood DO - http://dx.doi.org/10.1097/01.chi.0000233780.53785.a4 ER - TY - JOUR T1 - NIH to Map Genomic Changes of 3 Cancers AN - 219249546; 17133706 AB - The National Cancer Institute (NCI) und the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), announced on September 13 the first 3 cancers that will be studied in the pilot phase of The Cancer Genome Atlas TCGA* project: lung, brain (glioblastoma), and ovarian cancers. JF - The Journal of Nuclear Medicine AU - National Cancer Institute AU - National Human Genome Research Institute AD - National Cancer Institute ; National Human Genome Research Institute Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 22N EP - 27N CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Genomics KW - Medical research KW - Ovarian cancer KW - Pilot projects KW - Studies KW - Cancer KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Computational Biology -- methods KW - Chromosome Mapping KW - Male KW - Female KW - Genome, Human KW - Brain Neoplasms -- genetics KW - Ovarian Neoplasms -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219249546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIH+to+Map+Genomic+Changes+of+3+Cancers&rft.au=National+Cancer+Institute%3BNational+Human+Genome+Research+Institute&rft.aulast=National+Cancer+Institute&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=22N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - NIAID Awards $4 Million to Develop Anti-Radiation Treatments AN - 219184135; 17139786 AB - On September 25, the National Institute of Allergy and Infectious Diseases (NIAID), part of me National Institutes of Health (NIH), announced 5 awards totaling $4 million to fund the development of products that eliminate radioactive materials from the human body after radiologie or nuclear exposure. JF - The Journal of Nuclear Medicine AU - National Institute of Allergy and Infectious Diseases AD - National Institute of Allergy and Infectious Diseases Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1 CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Radioactive materials KW - Product development KW - Infectious diseases KW - Radiation KW - Allergies KW - Awards & honors KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Research -- trends KW - Radiation Injuries -- prevention & control KW - Research Support as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219184135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIAID+Awards+%244+Million+to+Develop+Anti-Radiation+Treatments&rft.au=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aulast=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - Cancer Death Rates Continue to Drop AN - 219181166; 17133705 AB - The report finds that for 1999 to 2003, Latinos had louer incidence rales than non-Hispanic whites (NHW) for most cancers, but were less likely than the NHW population to he diagnosed with localized stage disease for cancers of the lung, colon and rectum, prostate, female breast, and cervix. The report points to several important considerations in developing health inlerventions for Latinos, including: higher incidence of some infection-related cancers; elevated exposures to environmental risk factors in Latinos' living and work places; lower education, health literacy, and income; limited English proficiency; reduced use of screening services; limited access to health care, often because of lack of insurance; and less information available regarding possible genetic predisposition to cancer. JF - The Journal of Nuclear Medicine AU - National Institutes of Health AD - National Institutes of Health Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1 CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Womens health KW - Breast cancer KW - Tropical diseases KW - Risk factors KW - United States KW - Registries KW - Ethnic Groups KW - Humans KW - Incidence KW - Male KW - Female KW - Neoplasms -- mortality KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219181166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=Cancer+Death+Rates+Continue+to+Drop&rft.au=National+Institutes+of+Health&rft.aulast=National+Institutes+of+Health&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - REporting recommendations for tumor MARKer prognostic studies (REMARK) AN - 212473553; 16932852 AB - Despite years of research and hundreds of reports on tumor markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodologic problems have been cited to explain these discrepancies. Unfortunately, many tumor marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalizability of study results. The development of guidelines for the reporting of tumor marker studies was a major recommendation of the National Cancer Institute-European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. As for the successful CONSORT initiative for randomized trials and for the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, pre-planned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.[PUBLICATION ABSTRACT] JF - Breast Cancer Research and Treatment AU - Lisa M. McShaneDouglas G. AltmanWilli SauerbreiSheila E. TaubeMassimo GionGary M. Clark Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 229 EP - 35 CY - Dordrecht PB - Springer Science & Business Media VL - 100 IS - 2 SN - 01676806 KW - Medical Sciences--Oncology KW - Tumor Markers, Biological KW - Medical prognosis KW - Guidelines KW - Research methodology KW - Tumors KW - Humans KW - Prognosis KW - Guidelines as Topic KW - Research Design KW - Neoplasms -- diagnosis KW - Biomedical Research -- standards KW - Tumor Markers, Biological -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/212473553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Assessment+of+dermal+exposure+to+benzene+and+toluene+in+shoe+manufacturing+by+activated+carbon+cloth+patches.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BLi%2C+Guilan%3BRappaport%2C+Stephen+M%3BKim%2C+Sungkyoon%3Bvan+Wendel+de+Joode%2C+Berna%3BShen%2C+Min%3BBohong%2C+Xu%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BYin%2C+Songnian%3BRothman%2C+Nathaniel&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2006-11-01&rft.volume=8&rft.issue=11&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2006 N1 - Last updated - 2014-08-16 N1 - CODEN - BCTRD6 DO - http://dx.doi.org/10.1007/s10549-006-9242-8 ER - TY - JOUR T1 - An improved recombinant mammalian cell expression system for human transforming growth factor- beta 2 and - beta 3 preparations AN - 21035538; 8586352 AB - Transforming growth factor- beta 2 and - beta 3 (TGF- beta 2 and - beta 3) are important members of TGF- beta family which play important roles in the growth, maintenance, and repair processes of developing embryos, neonates, and adults. Preparation of large quantities of these two cytokines, which is necessary for structural studies and other applications, has proven to be extremely difficult. We have developed a novel Chinese hamster ovary cell-based expression system for high-level expression and high recovery of recombinant human TGF- beta 2 and - beta 3. In this system, we used a mammalian expression vector which contains a glutamine synthetase coding region for amplification, together with a modified TGF- beta 2 or - beta 3 open reading frame for expression. The leader peptide of TGF- beta 2 or - beta 3 was replaced by that from the V-J2-C region of a mouse immunoglobulin [kappa]-chain, and a poly-histidine tag was inserted immediately after the leader sequence to facilitate protein purification without changing the mature TGF- beta 2 or - beta 3 amino acid sequence. In addition, the extreme N-terminal cysteine residue of TGF- beta 2 or - beta 3 was replaced by a serine residue. The resulting expression constructs produced two stable cell clones expressing 10 mg of TGF- beta 2 and 8 mg of TGF- beta 3 per liter of spent medium. The purification scheme involved the use of two simple chromatographic steps with a typical yield of 5 mg of TGF- beta 2 and 4 mg of TGF- beta 3. This method represents a significant improvement over previously published methods and may be applicable to other TGF- beta superfamily members. We further confirmed that latent TGF- beta 2 and - beta 3 can be activated by proteolysis and glycolysis, which have not been reported before. JF - Protein Expression and Purification AU - Zou, Zhongcheng AU - Sun, Peter D AD - Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA, psun@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 9 EP - 17 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - protein purification KW - Protein sorting signals KW - Expression vectors KW - Glutamate-ammonia ligase KW - Mammalian cells KW - Cysteine KW - Cytokines KW - Transforming growth factor-^b KW - Embryos KW - Neonates KW - Glycolysis KW - Open reading frames KW - Serine KW - Amino acid sequence KW - Immunoglobulins KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=An+improved+recombinant+mammalian+cell+expression+system+for+human+transforming+growth+factor-+beta+2+and+-+beta+3+preparations&rft.au=Zou%2C+Zhongcheng%3BSun%2C+Peter+D&rft.aulast=Zou&rft.aufirst=Zhongcheng&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.06.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Transforming growth factor-^b; protein purification; Neonates; Glutamate-ammonia ligase; Serine; Protein sorting signals; Cytokines; Proteolysis; Embryos; Glycolysis; Cysteine; Expression vectors; Mammalian cells; Open reading frames; Immunoglobulins; Amino acid sequence DO - http://dx.doi.org/10.1016/j.pep.2006.06.022 ER - TY - JOUR T1 - Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: A Southwest Oncology Group study AN - 20864069; 7137474 AB - From February, 2001 to September, 2002, the Southwest Oncology Group (SWOG) accrued 65 patients with advanced gastric adenocarcinoma to a phase II trial of weekly 5-FU, leucovorin, and the orally-administered uridine analog PN401. Of these 65 patients, 57 were assessable for survival and toxicity, which were the endpoints for the study. Treatment consisted of the administration of 1200 mg/m super(2) of 5-FU, 500 mg/m super(2) of leucovorin, and 6 grams of PN401 every 8 h, beginning 8 h after the completion of the 5-FU infusion, and continuing for a total of 8 doses (48 grams) during each weekly chemotherapy session. Therapy was delivered for six weeks out of every 8-week treatment cycle. The gastrointestinal toxicity of this regimen was mild with 2 patients experiencing grade 3 stomatitis, and 6 patients having grade 3 diarrhea; and the hematologic toxicity was acceptable with 6 of 57 patients found to have had grade 3 or 4 leukopenia, and 14 of 57 patients experiencing grade 3 or 4 neutropenia. There were two deaths judged possibly related to treatment; one in a patient who experienced a variety of Grade 2 gastrointestinal toxicities and died at home with an unknown cause of death; and a second patient who also died at home, and for whom treatment-related sepsis could not be ruled out. The overall median survival was 7.2 months. The ability to safely deliver twice the usual dose of 5-FU with leucovorin on a weekly schedule suggests that oral uridine analog supplementation with PN401 may enhance the therapeutic index of the fluoropyrimidines. JF - Investigational New Drugs AU - Doroshow, James H AU - McCoy, Sheryl AU - Macdonald, John S AU - Issell, Brian F AU - Patel, Taral AU - Cobb, Patrick W AU - Yost, Kathleen J AU - Abbruzzese, James L AD - National Cancer Institute, City of Hope National Medical Center, Duarte, CA, doroshoj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 537 EP - 542 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 24 IS - 6 SN - 0167-6997, 0167-6997 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Diarrhea KW - Stomatitis KW - Chemotherapy KW - Survival KW - Oncology KW - Toxicity KW - Clinical trials KW - Supplementation KW - Metastases KW - Neutropenia KW - Sepsis KW - Uridine KW - Leukopenia KW - Adenocarcinoma KW - Stomach KW - X 24310:Pharmaceuticals KW - J 02400:Human Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20864069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Phase+II+trial+of+PN401%2C+5-FU%2C+and+leucovorin+in+unresectable+or+metastatic+adenocarcinoma+of+the+stomach%3A+A+Southwest+Oncology+Group+study&rft.au=Doroshow%2C+James+H%3BMcCoy%2C+Sheryl%3BMacdonald%2C+John+S%3BIssell%2C+Brian+F%3BPatel%2C+Taral%3BCobb%2C+Patrick+W%3BYost%2C+Kathleen+J%3BAbbruzzese%2C+James+L&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2006-11-01&rft.volume=24&rft.issue=6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-006-9244-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diarrhea; Stomatitis; Chemotherapy; Survival; Oncology; Toxicity; Clinical trials; Supplementation; Metastases; Neutropenia; Sepsis; Uridine; Adenocarcinoma; Leukopenia; Stomach DO - http://dx.doi.org/10.1007/s10637-006-9244-8 ER - TY - JOUR T1 - T measurement during first-pass contrast-enhanced cardiac perfusion imaging AN - 20860543; 8368314 AB - First-pass contrast-enhanced (CE) myocardial perfusion imaging will experience T effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T losses as well as off-resonance due to the bolus susceptibility. We hypothesized that T losses would not be significant for measurement of the AIF in full-dose studies using a short echo time (TE = 0.6 ms). The purpose of this study was to directly measure T in the LV cavity during first-pass perfusion. For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T signal intensity loss will be less than 10% using TE = 0.6 ms. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Aletras, Anthony H AU - Hsu, Li-yueh AU - McVeigh, Elliot R AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1132 EP - 1134 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cavities KW - Blood KW - Perfusion KW - Magnetic resonance imaging KW - Contrast media KW - Apoptosis-inducing factor KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=T+measurement+during+first-pass+contrast-enhanced+cardiac+perfusion+imaging&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=6&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Perfusion; imaging; Apoptosis-inducing factor; Blood; Magnetic resonance imaging; Cavities; Contrast media; Heart DO - http://dx.doi.org/10.1002/mrm.21061 ER - TY - JOUR T1 - Real-time interactive MRI-guided cardiac surgery: Aortic valve replacement using a direct apical approach AN - 20855451; 8368293 AB - Minimally invasive cardiac surgery requires arresting and emptying of the heart, which compromises visualization of the surgical field. In this feasibility study a novel surgical procedure is demonstrated in which real-time MRI is used to guide the placement of a prosthetic aortic valve in the beating heart via direct apical access in eight porcine hearts. A clinical stentless bioprosthetic valve affixed to a platinum stent was compressed onto a balloon-tipped catheter. This was fed through a 15-18-mm delivery port inserted into the left ventricular (LV) apex via a minimally invasive subxyphoid incision. Using interactive real-time MRI, the surgeon implanted the prosthetic valve in the correct location at the aortic annulus within 90 s. In four of the animals immediately after implantation, ventricular function, blood flow through the valve, and myocardial perfusion were evaluated with MRI. MRI-guided beating-heart surgery may provide patients with a less morbid and more durable solution to structural heart disease. JF - Magnetic Resonance in Medicine AU - McVeigh, Elliot R AU - Guttman, Michael A AU - Lederman, Robert J AU - Li, Ming AU - Kocaturk, Ozgur AU - Hunt, Timothy AU - Kozlov, Shawn AU - Horvath, Keith A AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, mcveigh@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 958 EP - 964 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Perfusion KW - Aortic valve KW - Aorta KW - Magnetic resonance imaging KW - prosthetic valves KW - Surgery KW - Platinum KW - Catheters KW - N.M.R. KW - Prosthetics KW - Heart diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+interactive+MRI-guided+cardiac+surgery%3A+Aortic+valve+replacement+using+a+direct+apical+approach&rft.au=McVeigh%2C+Elliot+R%3BGuttman%2C+Michael+A%3BLederman%2C+Robert+J%3BLi%2C+Ming%3BKocaturk%2C+Ozgur%3BHunt%2C+Timothy%3BKozlov%2C+Shawn%3BHorvath%2C+Keith+A&rft.aulast=McVeigh&rft.aufirst=Elliot&rft.date=2006-11-01&rft.volume=56&rft.issue=5&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Heart; Surgery; Magnetic resonance imaging; Aortic valve; Heart diseases; Prosthetics; N.M.R.; Aorta; Catheters; prosthetic valves; Platinum; Perfusion DO - http://dx.doi.org/10.1002/mrm.21044 ER - TY - JOUR T1 - Review of reported cholera outbreaks worldwide, 1995-2005 AN - 20753877; 7728299 AB - The global temporal and spatial distribution of cholera is underappreciated, given the lack of surveillance in endemic areas and economic disincentives to report outbreaks. To judge the use of specific novel interventions such as vaccines or anti-secretory agents, we compiled a database and analyzed cholera reports from the Program for Monitoring Emerging Diseases from 1995 to 2005. Of the 632 reports meeting the search criteria, 66% originated in Sub-Saharan Africa, followed by 16.8% from Southeast Asia. Reported outbreaks in Africa tended to be larger in size. The most common risk factors were water source contamination, heavy rainfall and flooding, and population dislocation. While cholera reporting is sub-optimal, this review provides a detailed sub-national quantification of cholera, identifies foci of endemicity in Africa, and describes risk factors by region. We highlight the need for more extensive outbreak reporting to justify investments in new interventions. JF - American Journal of Tropical Medicine and Hygiene AU - Griffith, D C AU - Kelly-Hope, LA AU - Miller, MA AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, 16 Center Drive, Bethesda, MD 20892, USA, millermark@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 973 EP - 977 VL - 75 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality KW - Environmental monitoring KW - Pollution monitoring KW - Spatial distribution KW - Contamination KW - Pathogenic bacteria KW - Rainfall KW - Bacterial diseases KW - Computer programs KW - Databases KW - Endemic species KW - Dislocation KW - Literature reviews KW - Reviews KW - Risk factors KW - Economics KW - Flooding KW - Africa KW - Cholera KW - Vaccines KW - Southeast Asia KW - Hygiene KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Review+of+reported+cholera+outbreaks+worldwide%2C+1995-2005&rft.au=Griffith%2C+D+C%3BKelly-Hope%2C+LA%3BMiller%2C+MA&rft.aulast=Griffith&rft.aufirst=D&rft.date=2006-11-01&rft.volume=75&rft.issue=5&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Pollution monitoring; Endemic species; Literature reviews; Pathogenic bacteria; Bacterial diseases; Flooding; Vaccines; Hygiene; Databases; Computer programs; Dislocation; Contamination; Spatial distribution; Rainfall; Risk factors; Reviews; Economics; Cholera; Africa; Southeast Asia ER - TY - JOUR T1 - Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex AN - 20727619; 7194055 AB - The development of protein subunit vaccines to combat some of the world's deadliest pathogens such as a malaria parasite, Plasmodium falciparum, is stalled, due in part to the inability to induce and sustain high-titer antibody responses. Here, we show the induction of persistent, high-titer antibody responses to recombinant Pfs25H, a human malarial transmission-blocking protein vaccine candidate, after chemical conjugation to the outer-membrane protein complex (OMPC) of Neisseria meningitidis serogroup B and adsorption to aluminum hydroxyphosphate. In mice, the Pfs25H-OMPC conjugate vaccine was >1,000 times more potent in generating anti-Pfs25H ELISA reactivity than a similar 0.5- mu g dose of Pfs25H alone in Montanide ISA720, a water-in-oil adjuvant. The immune enhancement requires covalent conjugation between Pfs25H and the OMPC, given that physically mixed Pfs25H and OMPC on aluminum hydroxyphosphate failed to induce greater activity than the nonconjugated Pfs25H on aluminum hydroxyphosphate. The conjugate vaccine Pfs25H-OMPC also was highly immunogenic in rabbits and rhesus monkeys. In rhesus monkeys, the antibody responses were sustained over 18 months, at which time another vaccination with nonconjugated Pfs25H induced strong anamnestic responses. The vaccine-induced anti-Pfs25-specific antibodies in all animal species blocked the transmission of parasites to mosquitoes. Protein antigen conjugation to OMPC or other protein carrier may have general application to a spectrum of protein subunit vaccines to increase immunogenicity without the need for potentially reactogenic adjuvants. JF - Proceedings of the National Academy of Sciences, USA AU - Wu, Yimin AU - Przysiecki, Craig AU - Flanagan, Elizabeth AU - Bello-Irizarry, Sheila N AU - Ionescu, Roxana AU - Muratova, Olga AU - Dobrescu, Gelu AU - Lambert, Lynn AU - Keister, David AU - Rippeon, Yvette AU - Long, Carole A AU - Shi, Li AU - Caulfield, Michael AU - Shaw, Alan AU - Saul, Allan AU - Shiver, John AU - Miller, Louis H AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 18243 EP - 18248 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 48 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Enzyme-linked immunosorbent assay KW - Conjugation KW - Disease control KW - Malaria KW - Neisseria meningitidis KW - Plasmodium falciparum KW - Adjuvants KW - Pathogens KW - Antibodies KW - Antigens KW - Immunogenicity KW - Aluminum KW - Aluminium KW - Adsorption KW - ELISA KW - Macaca mulatta KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Sustained+high-titer+antibody+responses+induced+by+conjugating+a+malarial+vaccine+candidate+to+outer-membrane+protein+complex&rft.au=Wu%2C+Yimin%3BPrzysiecki%2C+Craig%3BFlanagan%2C+Elizabeth%3BBello-Irizarry%2C+Sheila+N%3BIonescu%2C+Roxana%3BMuratova%2C+Olga%3BDobrescu%2C+Gelu%3BLambert%2C+Lynn%3BKeister%2C+David%3BRippeon%2C+Yvette%3BLong%2C+Carole+A%3BShi%2C+Li%3BCaulfield%2C+Michael%3BShaw%2C+Alan%3BSaul%2C+Allan%3BShiver%2C+John%3BMiller%2C+Louis+H&rft.aulast=Wu&rft.aufirst=Yimin&rft.date=2006-11-01&rft.volume=103&rft.issue=48&rft.spage=18243&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Conjugation; Antibodies; Antigens; Aluminium; Disease control; ELISA; Pathogens; Vaccines; Enzyme-linked immunosorbent assay; Immunogenicity; Aluminum; Adsorption; Malaria; Adjuvants; Macaca mulatta; Plasmodium falciparum; Neisseria meningitidis ER - TY - JOUR T1 - The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria AN - 20724558; 7120598 AB - Toxin-antitoxin systems (TAS) are abundant, diverse, horizontally mobile gene modules that encode powerful resistance mechanisms in prokaryotes. We use the comparative-genomic approach to predict a new TAS that consists of a two-gene cassette encoding uncharacterized HicA and HicB proteins. Numerous bacterial and archaeal genomes encode from one to eight HicAB modules which appear to be highly prone to horizontal gene transfer. The HicB protein (COG1598/COG4226) has a partially degraded RNAse H fold, whereas HicA (COG1724) contains a double-stranded RNA-binding domain. The stable combination of these two domains suggests a link to RNA metabolism, possibly, via an RNA interference-type mechanism. In most HicB proteins, the RNAse H-like domain is fused to a DNA-binding domain, either of the ribbon-helix-helix or of the helix-turn-helix class; in other TAS, proteins containing these DNA-binding domains function as antitoxins. Thus, the HicAB module is predicted to be a novel TAS whose mechanism involves RNA-binding and, possibly, cleavage. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Makarova, Kira S AU - Grishin, Nick V AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA. Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard, Dallas, TX 75390-9050, USA, koonin@ncbi.nlm.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 2581 EP - 2584 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 21 SN - 1367-4803, 1367-4803 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Antitoxins KW - Data processing KW - Archaea KW - ribonuclease A KW - RNA KW - Gene transfer KW - Ribonuclease H KW - ribonuclease H KW - Ribonuclease KW - Bioinformatics KW - Prokaryotes KW - Metabolism KW - A 01490:Miscellaneous KW - J 02330:Biochemistry KW - X 24490:Other KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=The+HicAB+cassette%2C+a+putative+novel%2C+RNA-targeting+toxin-antitoxin+system+in+archaea+and+bacteria&rft.au=Makarova%2C+Kira+S%3BGrishin%2C+Nick+V%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2006-11-01&rft.volume=22&rft.issue=21&rft.spage=2581&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antitoxins; Genomes; ribonuclease A; Data processing; RNA; Gene transfer; Ribonuclease H; ribonuclease H; Ribonuclease; Prokaryotes; Bioinformatics; Metabolism; Archaea ER - TY - JOUR T1 - A Comparison of the Emission Efficiency of Four Common Green Fluorescence Dyes after Internalization into Cancer Cells AN - 20358055; 7598594 AB - In vivo optical imaging to enhance the detection of cancer during endoscopy or surgery requires a targeted fluorescent probe with high emission efficiency and high signal-to-background ratio. One strategy to accurately detect cancers is to have the fluorophore internalize within the cancer cells permitting nonbound fluorophores to be washed away or absorbed. The choice of fluorophores for this task must be carefully considered. For depth of penetration, near-infrared probes are ordinarily preferred but suffer from relatively low quantum efficiency. Although green fluorescent protein has been widely used to image tumors on internal organs in mice, green fluorescent probes are better suited for imaging the superficial tissues because of the short penetration distance of green light in tissue and the highly efficient production of signal. While the fluorescence properties of green fluorophores are well-known in vitro, less attention has been paid to their fluorescence once they are internalized within cells. In this study, the emission efficiency after cellular internalization of four common green fluorophores conjugated to avidin (Av-fluorescein, Av-Oregon green, Av-BODIPY-FL, and Av-rhodamine green) were compared after each conjugate was incubated with SHIN3 ovarian cancer cells. Using the lectin binding receptor system, the avidin-fluorophore conjugates were endocytosed, and their fluorescence was evaluated with fluorescence microscopy and flow cytometry. While fluorescein demonstrated the highest signal outside the cell, among the four fluorophores, internalized Av-rhodamine green emitted the most light from SHIN3 ovarian cancer cells both in vitro and in vivo. The internalized Av-rhodamine green complex appeared to localize to the endoplasmic vesicles. Thus, among the four common green fluorescent dyes, rhodamine green is the brightest green fluorescence probe after cellular internalization. This information could have implications for the design of tumor-targeted fluorescent probes that rely on cellular internalization for cancer detection. JF - Bioconjugate Chemistry AU - Hama, Y AU - Urano, Y AU - Koyama, Y AU - Bernardo, M AU - Choyke, P L AU - Kobayashi, H AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1426 EP - 1431 VL - 17 IS - 6 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Green fluorescent protein KW - Probes KW - Lectins KW - Tumors KW - fluorophores KW - imaging KW - Light effects KW - Endoscopy KW - fluorescein KW - Flow cytometry KW - Avidin KW - Dyes KW - Surgery KW - Fluorescent indicators KW - Vesicles KW - rhodamine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=A+Comparison+of+the+Emission+Efficiency+of+Four+Common+Green+Fluorescence+Dyes+after+Internalization+into+Cancer+Cells&rft.au=Hama%2C+Y%3BUrano%2C+Y%3BKoyama%2C+Y%3BBernardo%2C+M%3BChoyke%2C+P+L%3BKobayashi%2C+H&rft.aulast=Hama&rft.aufirst=Y&rft.date=2006-11-01&rft.volume=17&rft.issue=6&rft.spage=1426&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0601626 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Probes; Green fluorescent protein; Lectins; fluorophores; Tumors; imaging; fluorescein; Endoscopy; Light effects; Flow cytometry; Avidin; Dyes; Surgery; Fluorescent indicators; Vesicles; rhodamine DO - http://dx.doi.org/10.1021/bc0601626 ER - TY - JOUR T1 - Molecular Analysis of Base Damage Clustering Associated with a Site-Specific Radiation-Induced DNA Double-Strand Break AN - 20277584; 7235230 AB - Base damage flanking a radiation-induced DNA double-strand break (DSB) may contribute to DSB complexity and affect break repair. However, to date, an isolated radiation-induced DSB has not been assessed for such structures at the molecular level. In this study, an authentic site-specific radiation-induced DSB was produced in plasmid DNA by triplex forming oligonucleotide-targeted super(125)I decay. A restriction fragment terminated by the DSB was isolated and probed for base damage with the E. coli DNA repair enzymes endonuclease III and formamidopyrimidine-DNA glycosylase. Our results demonstrate base damage clustering within 8 bases of the super(125)I-targeted base in the DNA duplex. An increased yield of base damage (purine > pyrimidine) was observed for DSBs formed by irradiation in the absence of DMSO. An internal control fragment 1354 bp upstream from the targeted base was insensitive to enzymatic probing, indicating that the damage detected proximal to the DSB was produced by the super(125)I decay that formed the DSB. Gas chromatography-mass spectrometry identified three types of damaged bases in the similar to 32-bp region proximal to the DSB. These base lesions were 8-hydroxyguanine, 8-hydroxyadenine and 5-hydroxycytosine. Finally, evidence is presented for base damage >24 bp upstream from the super(125)I-decay site that may form via a charge migration mechanism. JF - Radiation Research AU - Datta, K AU - Jaruga, P AU - Dizdaroglu, M AU - Neumann, R D AU - Winters, T A AD - Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 767 EP - 781 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 166 IS - 5 SN - 0033-7587, 0033-7587 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Enzymes KW - Double-strand break repair KW - DNA repair KW - Plasmids KW - Migration KW - Mass spectroscopy KW - purines KW - DNA damage KW - 8-Hydroxyguanine KW - Gas chromatography KW - Escherichia coli KW - pyrimidines KW - formamidopyrimidine-DNA glycosylase KW - Endonuclease KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20277584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Molecular+Analysis+of+Base+Damage+Clustering+Associated+with+a+Site-Specific+Radiation-Induced+DNA+Double-Strand+Break&rft.au=Datta%2C+K%3BJaruga%2C+P%3BDizdaroglu%2C+M%3BNeumann%2C+R+D%3BWinters%2C+T+A&rft.aulast=Datta&rft.aufirst=K&rft.date=2006-11-01&rft.volume=166&rft.issue=5&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0628.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=166&issue=5&page=767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzymes; Plasmids; DNA repair; Double-strand break repair; Migration; purines; Mass spectroscopy; DNA damage; 8-Hydroxyguanine; Gas chromatography; formamidopyrimidine-DNA glycosylase; pyrimidines; Endonuclease; Escherichia coli DO - http://dx.doi.org/10.1667/RR0628.1 ER - TY - JOUR T1 - Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line AN - 20240809; 7166416 AB - Ectopic accumulation of lipid droplets in non-adipose tissues correlates with the degree of insulin resistance in these tissues. Emerging evidence indicates that lipid droplets are specialized organelles that participate in lipid metabolism and intracellular trafficking. These properties are thought to derive from the lipid droplet-associated PAT protein family (perilipin, ADFP, and Tip47). The functions of the ubiquitously distributed adipose differentiation-related protein (ADFP) and Tip47 remain unknown. To evaluate the roles of ADFP and Tip47 in lipid biogenesis and metabolism, ADFP null and wild type (wt) clonal cell lines were established from ADFP null and wt mice, respectively. In ADFP null cells, Tip47 was identified as the sole lipid droplet-associated protein from the PAT family by mass spectroscopy, which was further confirmed by immunoblotting and immunocytochemistry. Following incubation with oleic acid, ADFP null cells were able to form lipid droplets to the same extent as wt cells. No statistical differences between the two cell types were observed in NEFA uptake or lipolysis. Small interference RNAs (siRNAs) against Tip47 were found to down-regulate protein levels for Tip47 by 85%. ADFP null cells treated with Tip47 siRNA retained the ability to form lipid droplets but to a lesser extent and shunted the utilization of exogenously added NEFA from triglycerides to phospholipids. These data support the hypothesis that Tip47 plays an important role in lipid metabolism. Tip47 and ADFP in peripheral tissues may play a critical role in regulating the formation and turnover, and hence metabolic consequences, of ectopic fat. JF - Journal of Biological Chemistry AU - Sztalryd, Carole AU - Bell, Ming AU - Lu, Xinyue AU - Mertz, Pamela AU - Hickenbottom, Sabrina AU - Chang, Benny H-J AU - Chan, Lawrence AU - Kimmel, Alan R AU - Londos, Constantine AD - Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, the Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-8028, and the Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas 77030 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 34341 EP - 34348 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 45 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Immunocytochemistry KW - Data processing KW - Statistics KW - Null cells KW - protein families KW - Insulin KW - Lipid metabolism KW - siRNA KW - Triglycerides KW - Embryos KW - Lipolysis KW - Organelles KW - Oleic acid KW - Phospholipids KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Anti-HIV-1+immunotoxin+3B3%28Fv%29-PE38%3A+Enhanced+potency+against+clinical+isolates+in+human+PBMCs+and+macrophages%2C+and+negligible+hepatotoxicity+in+macaques&rft.au=Kennedy%2C+P+E%3BBera%2C+T+K%3BWang%2C+Q-C%3BGallo%2C+M%3BWagner%2C+W%3BLewis%2C+M+G%3BBerger%2C+E+A%3BPastan%2C+I&rft.aulast=Kennedy&rft.aufirst=P&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immunocytochemistry; Immunoblotting; Statistics; Data processing; Null cells; protein families; Insulin; Lipid metabolism; siRNA; Triglycerides; Embryos; Lipolysis; Organelles; Oleic acid; Phospholipids ER - TY - JOUR T1 - Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis AN - 20235975; 7166862 AB - Prior studies indicated the ability of Abs to complement receptor 3 (CR3, CD11b/CD18) to suppress the production of IL-12 from immune cells. Therefore, we tested the ability of an anti-CR3 Ab (clone M1/70) to treat established IL-12-dependent Th1-mediated inflammation in murine models. Systemic administration of anti-CR3 significantly ameliorated established intestinal inflammation following the intrarectal administration of trinitrobenzene sulfonic acid (TNBS-colitis), as well as colitis and skin inflammation in C57BL/10 RAG-2 super(-/-) mice reconstituted with CD4 super(+)CD45RB super(high) T cells. The hyperproliferative skin inflammation in this novel murine model demonstrated many characteristics of human psoriasis, and was prevented by the adoptive transfer of CD45RB super(low) T cells. In vitro and in vivo studies suggest that anti-CR3 treatment may act, at least in part, by directly inhibiting IL-12 production by APCs. Administration of anti-CR3 may be a useful therapeutic approach to consider for the treatment of inflammatory bowel disease and psoriasis in humans. JF - Journal of Immunology AU - Leon, Francisco AU - Contractor, Nikhat AU - Fuss, Ivan AU - Marth, Thomas AU - Lahey, Edward AU - Iwaki, Shoko AU - la Sala, Andrea AU - Hoffmann, Victoria AU - Strober, Warren AU - Kelsall, Brian L AD - Laboratory of Molecular Immunology, Laboratory of Host Defense, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Office of Research Services, Division of Veterinary Resources, Office of the Director, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6974 EP - 6982 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Skin KW - sulfonic acid KW - Animal models KW - CD18 antigen KW - Interleukin 12 KW - Antibodies KW - Inflammatory bowel diseases KW - Psoriasis KW - CD11b antigen KW - Adoptive transfer KW - Lymphocytes T KW - Intestine KW - complement receptor 3 KW - Antigen-presenting cells KW - Colitis KW - Dermatitis KW - W 30940:Products KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Antibodies+to+Complement+Receptor+3+Treat+Established+Inflammation+in+Murine+Models+of+Colitis+and+a+Novel+Model+of+Psoriasiform+Dermatitis&rft.au=Leon%2C+Francisco%3BContractor%2C+Nikhat%3BFuss%2C+Ivan%3BMarth%2C+Thomas%3BLahey%2C+Edward%3BIwaki%2C+Shoko%3Bla+Sala%2C+Andrea%3BHoffmann%2C+Victoria%3BStrober%2C+Warren%3BKelsall%2C+Brian+L&rft.aulast=Leon&rft.aufirst=Francisco&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=6974&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Skin; Animal models; sulfonic acid; CD18 antigen; Interleukin 12; Antibodies; Inflammatory bowel diseases; Psoriasis; CD11b antigen; Intestine; Lymphocytes T; Adoptive transfer; complement receptor 3; Antigen-presenting cells; Colitis; Dermatitis ER - TY - JOUR T1 - Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates AN - 20234574; 7079049 AB - A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. To evaluate the preventive potential of the Se compounds against Cd induced hepatic lipid peroxidation and oxidative stress, female Swiss Albino mice were exposed to Cd (as CdCl sub(2)) during 20 days at a dose of 1 or 2 mg/kg bw given ip and the selenium compounds were given at the dose of 3 mg/kg bw orally in a pretreatment and concomitant treatment schedule. Hepatic lipid peroxidation level was increased significantly by Cd, whereas the glutathione-S-transferase (GST), superoxide dismutase(SOD), reduced glutathione(GSH) and catalase(CAT) levels were decreased. The selenium compounds effectively decreased the hepatic lipid peroxidation level of the animals treated with Cd. The compounds were also effective in restoring the GST, SOD, and GSH as well as CAT level towards normal. Cadmium induced enhanced Serum alanine aminotransferase (ALT) and aspertate aminotransferase (AST) le JF - Environmental Toxicology and Pharmacology AU - Sk, Ugir Hossain AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700 026, West Bengal, India, sudinb19572004@yahoo.co.in Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 298 EP - 308 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 1382-6689, 1382-6689 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Organoselenocyanates KW - Lipid peroxidation KW - Cadmium KW - Liver KW - Mice KW - Selenium compounds KW - Oxidative stress KW - Superoxide dismutase KW - Glutathione KW - Enzymes KW - Glutathione transferase KW - Alanine transaminase KW - W 30940:Products KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Prevention+of+cadmium+induced+lipid+peroxidation%2C+depletion+of+some+antioxidative+enzymes+and+glutathione+by+a+series+of+novel+organoselenocyanates&rft.au=Sk%2C+Ugir+Hossain%3BBhattacharya%2C+Sudin&rft.aulast=Sk&rft.aufirst=Ugir&rft.date=2006-11-01&rft.volume=22&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Selenium compounds; Glutathione; Superoxide dismutase; Oxidative stress; Liver; Enzymes; Cadmium; Alanine transaminase; Glutathione transferase; Lipid peroxidation DO - http://dx.doi.org/10.1016/j.etap.2006.04.004 ER - TY - JOUR T1 - The RNase a superfamily: Generation of diversity and innate host defense AN - 20201639; 7309920 AB - The Ribonuclease A superfamily includes an extensive network of distinct and divergent gene lineages. Although all ribonu cleases of this superfamily share invariant structural and catalytic elements and some degree of enzymatic activity, the primary sequences have diverged significantly, ostensibly to promote novel function. We will review the literature on the evolution and biology of the RNase A ribonuclease lineages that have been characterized specifically as involved in host defense including: (1) RNases 2 and RNases 3, also known as the eosinophil ribonucleases, which are rapidly-evolving cationic proteins released from eosinophilic leukocytes, (2) RNase 7, an anti-pathogen ribonuclease identified in human skin, and (3) RNase 5, also known as angiogenin, another rapidly-evolving ribonuclease known to promote blood vessel growth with recently-discovered antibacterial activity. Interestingly, some of the characterized anti-pathogen activities do not depend on ribonuclease activity per se. We discuss the ways in which the anti-pathogen activities characterized in vitro might translate into experimental confirmation in vivo. We will also consider the possibility that other ribonucleases, such as the dimeric bovine seminal ribonuclease and the frog oocyte ribonucleases, may have host defense functions and therapeutic value that remain to be explored. JF - Molecular Diversity AU - Dyer, K D AU - Rosenberg, H F AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, hrosenberg@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 585 EP - 597 VL - 10 IS - 4 SN - 1381-1991, 1381-1991 KW - Frogs KW - Toads KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Skin KW - Antibacterial activity KW - Anura KW - Leukocytes (eosinophilic) KW - ribonuclease 7 KW - ribonuclease A KW - Angiogenin KW - Blood vessels KW - Reviews KW - Oocytes KW - Ribonuclease KW - Enzymatic activity KW - Offense KW - Evolution KW - N 14835:Protein-Nucleic Acids Association KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20201639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Diversity&rft.atitle=The+RNase+a+superfamily%3A+Generation+of+diversity+and+innate+host+defense&rft.au=Dyer%2C+K+D%3BRosenberg%2C+H+F&rft.aulast=Dyer&rft.aufirst=K&rft.date=2006-11-01&rft.volume=10&rft.issue=4&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Molecular+Diversity&rft.issn=13811991&rft_id=info:doi/10.1007%2Fs11030-006-9028-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - SuppNotes - Special Issue: Molecular Diversity of Proteins in Biological offense and Defense Systems. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Skin; Antibacterial activity; Leukocytes (eosinophilic); ribonuclease 7; ribonuclease A; Angiogenin; Blood vessels; Reviews; Ribonuclease; Oocytes; Enzymatic activity; Offense; Evolution; Anura DO - http://dx.doi.org/10.1007/s11030-006-9028-2 ER - TY - JOUR T1 - Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide AN - 20098459; 7148286 AB - Exposure of cells to ionizing radiation (IR) produces changes in the expression level of a large number of genes. However, less is known of gene-expression changes caused by local radiation exposure from radionuclides within cells. We studied changes in the genome-wide gene expression induced by decay of super(1) super(2) super(5)I incorporated into DNA as [ super(1) super(2) super(5)I]-iododeoxyuridine ( super(1) super(2) super(5)I-IUdR) in normal IMR-90 human lung fibroblasts and compared them with the changes produced by external gamma -radiation delivered at high (HDR) or low (LDR) dose rate. We found that more than 2000 genes were consistently up- or down-regulated following HDR and LDR gamma -radiation. The profiles of differentially expressed genes following HDR and LDR shared about 64% (up) and 74% (down) genes in common, with many genes identified as radiation-responsive for the first time. In contrast, in all only 206 genes changed their expression level in the super(1) super(2) super(5)I-IUdR-treated cells, even though the total number of DNA double-strand breaks (DSB) produced by super(1) super(2) super(5)I-IUdR exceeded that produced by the gamma -radiation. With few exceptions, the expression levels of super(1) super(2) super(5)I-IUdR-responsive genes were also altered following gamma -irradiation. Therefore, nuclear DNA-localized decays of super(1) super(2) super(5)I produce 10 times fewer differentially expressed genes than whole-cell exposure to gamma -radiation of comparable dose. These results suggest that the effect of IR on the changes in global gene expression depends on the distribution of energy depositions within the cell. In contrast to cell survival, DNA DSB may not be the major factor modulating changes in gene expression following irradiation. JF - Gene AU - Sokolov, M V AU - Smirnova, NA AU - Camerini-Otero, R D AU - Neumann, R D AU - Panyutin, I G AD - Clinical Center, NIH, Bldg. 10 Room 4D45, 9000 Rockville Pike, Bethesda, MD 20892, United States, igorp@helix.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 47 EP - 56 PB - Elsevier B.V. VL - 382 SN - 0378-1119, 0378-1119 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Cell survival KW - Gene expression KW - DNA damage KW - Lung KW - Ionizing radiation KW - Energy KW - Radioisotopes KW - DNA KW - Fibroblasts KW - G 07710:Chemical Mutagenesis & Radiation KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20098459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Microarray+analysis+of+differentially+expressed+genes+after+exposure+of+normal+human+fibroblasts+to+ionizing+radiation+from+an+external+source+and+from+DNA-incorporated+iodine-125+radionuclide&rft.au=Sokolov%2C+M+V%3BSmirnova%2C+NA%3BCamerini-Otero%2C+R+D%3BNeumann%2C+R+D%3BPanyutin%2C+I+G&rft.aulast=Sokolov&rft.aufirst=M&rft.date=2006-11-01&rft.volume=382&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2006.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Cell survival; DNA damage; Lung; Energy; Ionizing radiation; DNA; Radioisotopes; Fibroblasts DO - http://dx.doi.org/10.1016/j.gene.2006.06.008 ER - TY - JOUR T1 - The Minimal Instrumentation Requirements for Hoechst Side Population Analysis: Stem Cell Analysis on Low-Cost Flow Cytometry Platforms AN - 20010991; 7126889 AB - The Hoechst side population (SP) technique is a critical method of identifying stem cells and early progenitors in rodent, nonhuman primate, and human hematopoietic and nonhematopoietic tissues. In this technique, the cell-permeable DNA-binding dye Hoechst 33342 is loaded into the cell population of interest; stem cells and early progenitors subsequently pump this dye out via an ATP-binding cassette membrane pump-dependent mechanism, resulting in a low-fluorescence "tail" (the SP) when the cells are analyzed by flow cytometry. This population contains stem cells and early progenitors. One significant drawback of this method is the requirement of an UV laser to excite the Hoechst 33342. Unfortunately, flow cytometers equipped with UV sources are expensive to own and operate and are not readily available to many laboratories or institutions. In the interests of designing a less expensive flow cytometric system for stem cell analysis, we determined the minimum UV excitation and instrumentation requirements for measuring Hoechst SP. Less than 3 mW of UV laser output was required for adequate resolution of Hoechst SP on two cuvette-based flow cytometers, one of which was a simple, inexpensive benchtop analyzer (the Quanta Analyzer; NPE Systems). Furthermore, Hoechst SP could also be adequately resolved on this epifluorescence-based cytometer platform using two nonlaser UV sources, a mercury arc lamp with a UV bandpass filter and a UV-emitting light-emitting diode. These results suggest that an economical flow cytometric system can be designed that is capable of resolving Hoechst SP, with a cost far lower than most UV laser-equipped commercial systems. An inexpensive system of this type would make Hoechst SP analysis available to a much broader group of stem cell investigators. JF - Stem Cells AU - Cabana, Raquel AU - Frolova, Ella G AU - Kapoor, Veena AU - Thomas, Richard A AU - Krishan, Awtar AU - Telford, William G AD - NPE Systems, Pembroke Pines, Florida, USA. Metabolism Branch, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute-NIH, Bethesda, Maryland, USA. University of Miami School of Medicine, Miami, Florida, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2573 EP - 2581 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Filters KW - Stem cells KW - Tails KW - Hemopoiesis KW - Mercury KW - Lasers KW - Primates KW - Substance P KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20010991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Minimal+Instrumentation+Requirements+for+Hoechst+Side+Population+Analysis%3A+Stem+Cell+Analysis+on+Low-Cost+Flow+Cytometry+Platforms&rft.au=Cabana%2C+Raquel%3BFrolova%2C+Ella+G%3BKapoor%2C+Veena%3BThomas%2C+Richard+A%3BKrishan%2C+Awtar%3BTelford%2C+William+G&rft.aulast=Cabana&rft.aufirst=Raquel&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=2573&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Filters; Flow cytometry; Stem cells; Tails; Mercury; Hemopoiesis; Lasers; Substance P; Primates ER - TY - JOUR T1 - Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: Enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques AN - 20000842; 7307083 AB - Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, leading invariably to viral rebound upon cessation of treatment. Toxins engineered to target the Env glycoprotein on the surface of productively infected cells represent a complementary strategy to deplete these reservoirs. We described previously highly selective killing of Env-expressing cell lines by CD4(178)-PE40 and 3B3(Fv)-PE38, recombinant derivatives of Pseudomonas aeruginosa exotoxin A containing distinct targeting moieties against gp120. In the present report, we compare the in vitro potency and breadth of these chimeric toxins against multiple clinical HIV-1 isolates, replicating in biologically relevant primary human target cell types. In PBMCs, 3B3(Fv)-PE38 blocked spreading infection by all isolates examined, with greater potency than CD4(178)-PE40. 3B3(Fv)-PE38 also potently inhibited spreading HIV-1 infection in primary macrophages. Control experiments demonstrated that in both target cell types, most of the 3B3(Fv)-PE38 activity was due to selective killing of infected cells, and not merely to neutralization by the antibody moiety of the chimeric toxin. High-dose treatment of rhesus macaques with 3B3(Fv)-PE38 did not induce liver toxicity, whereas equivalent dosage of CD4(178)-PE40 induced mild hepatotoxicity. These findings highlight the potential use of 3B3 (Fv)-PE38 for depleting HIV-infected cell reservoirs persisting in the face of HAART. JF - Journal of Leukocyte Biology AU - Kennedy, P E AU - Bera, T K AU - Wang, Q-C AU - Gallo, M AU - Wagner, W AU - Lewis, M G AU - Berger, E A AU - Pastan, I AD - Laboratory of Viral Diseases, NIAID National Institutes of Health Building 4, Room 237 Bethesda, MD 20892, USA, edward_berger@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1175 EP - 1182 VL - 80 IS - 5 SN - 0741-5400, 0741-5400 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Clinical isolates KW - Macrophages KW - Mortality KW - Spreading KW - Replication KW - Leukocytes KW - Toxicity KW - Infection KW - exotoxin A KW - Morbidity KW - Immunotoxins KW - hepatotoxicity KW - Toxins KW - Glycoprotein gp120 KW - Antibodies KW - highly active antiretroviral therapy KW - Human immunodeficiency virus 1 KW - Liver KW - Macaca mulatta KW - Pseudomonas aeruginosa KW - V 22360:AIDS and HIV KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20000842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Anti-HIV-1+immunotoxin+3B3%28Fv%29-PE38%3A+Enhanced+potency+against+clinical+isolates+in+human+PBMCs+and+macrophages%2C+and+negligible+hepatotoxicity+in+macaques&rft.au=Kennedy%2C+P+E%3BBera%2C+T+K%3BWang%2C+Q-C%3BGallo%2C+M%3BWagner%2C+W%3BLewis%2C+M+G%3BBerger%2C+E+A%3BPastan%2C+I&rft.aulast=Kennedy&rft.aufirst=P&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Clinical isolates; Mortality; Spreading; Replication; Leukocytes; Toxicity; Infection; exotoxin A; Toxins; hepatotoxicity; Immunotoxins; Morbidity; Glycoprotein gp120; Antibodies; highly active antiretroviral therapy; Liver; Human immunodeficiency virus 1; Macaca mulatta; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1189/jlb.0306139 ER - TY - JOUR T1 - Mycobacterium avium-induced SOCS contributes to resistance to IFN- gamma -mediated mycobactericidal activity in human macrophages AN - 19973613; 7307079 AB - Mycobacterium avium is an opportunistic pathogen that commonly infects individuals colonized with HIV-1, although it is less frequent in the post-HAART era. These microorganisms invade macrophages after interacting with TLR2 and/or CD14 co-receptors, but signaling pathways promoting survival in macrophages are not well defined. Although IFN- gamma plays an important role in protective immunity against bacterial infections, IFN- gamma responses are compromised in AIDS patients and evidence suggests that exogenous IFN- gamma is inadequate to clear the mycobacteria. To determine the mechanism by which M. avium survives intracellularly, even in the presence of IFN- gamma , we studied the effect of mycobacteria infection in macrophages during early IFN- gamma signaling events. M. avium infected cells exhibited a reduced response to IFN- gamma , with suppressed phosphorylation of STAT-1 compared with uninfected cells. Interaction of M. avium with macrophage receptors increased gene expression of the suppressors of cytokine signaling (SOCS) to diminish IFN responsiveness. Specifically, we observed an increase in mRNA for both SOCS-3 and SOCS-1, which correlates with elevated levels of SOCS protein and positive immunostaining in M. avium/HIV-1 co-infected tissues. We also linked the p38 MAPK signaling pathway to mycobacterial-induced SOCS gene transcription. The induction of SOCS may be part of the strategy that allows the invader to render the macrophages unresponsive to IFN- gamma , which otherwise promotes clearance of the infection. Our data provide new insights into the manipulation of the host response by this opportunistic pathogen and the potential for modulating SOCS to influence the outcome of M. avium infection in immunocompromised hosts. JF - Journal of Leukocyte Biology AU - Vazquez, N AU - Teresa, G-W AU - Rekka, S AU - Orenstein, J M AU - Wahl, S M AD - Building 30, 30 Convent Dr., MSC 4352, OIIB NIDCR, NIH, Bethesda, MD 20892-4352, USA, nvazquez@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1136 EP - 1144 VL - 80 IS - 5 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Cell survival KW - gamma -Interferon KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - TLR2 protein KW - Infection KW - CD14 antigen KW - Gene expression KW - Phosphorylation KW - Human immunodeficiency virus 1 KW - MAP kinase KW - soc gene KW - Data processing KW - Leukocytes KW - Transcription KW - Pathogens KW - Immunity KW - Opportunist infection KW - Interferon KW - Stat1 protein KW - Immunocompromised hosts KW - Microorganisms KW - Toll-like receptors KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19973613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Mycobacterium+avium-induced+SOCS+contributes+to+resistance+to+IFN-+gamma+-mediated+mycobactericidal+activity+in+human+macrophages&rft.au=Vazquez%2C+N%3BTeresa%2C+G-W%3BRekka%2C+S%3BOrenstein%2C+J+M%3BWahl%2C+S+M&rft.aulast=Vazquez&rft.aufirst=N&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Macrophages; gamma -Interferon; MAP kinase; Acquired immune deficiency syndrome; Data processing; soc gene; Leukocytes; TLR2 protein; Transcription; Immunity; Pathogens; CD14 antigen; Infection; Opportunist infection; Gene expression; Interferon; Phosphorylation; Stat1 protein; Immunocompromised hosts; Microorganisms; Toll-like receptors; Signal transduction; Mycobacterium avium; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1189/jlb.0306206 ER - TY - JOUR T1 - Refined Spatial Manipulation of Neuronal Function by Combinatorial Restriction of Transgene Expression AN - 19967411; 7139355 AB - Selective genetic manipulation of neuronal function in vivo requires techniques for targeting gene expression to specific cells. Existing systems accomplish this using the promoters of endogenous genes to drive expression of transgenes directly in cells of interest or, in "binary" systems, to drive expression of a transcription factor or recombinase that subsequently activates the expression of other transgenes. All such techniques are constrained by the limited specificity of the available promoters. We introduce here a combinatorial system in which the DNA-binding (DBD) and transcription-activation (AD) domains of a transcription factor are independently targeted using two different promoters. The domains heterodimerize to become transcriptionally competent and thus drive transgene expression only at the intersection of the expression patterns of the two promoters. We use this system to dissect a neuronal network in Drosophila by selectively targeting expression of the cell death gene reaper to subsets of neurons within the network. JF - Neuron AU - Luan, Haojiang AU - Peabody, Nathan C AU - Vinson, Charles R AU - White, Benjamin H AD - Laboratory of Molecular Biology, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, benjaminwhite@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 425 EP - 436 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 52 IS - 3 SN - 0896-6273, 0896-6273 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Entomology Abstracts KW - MOLNEURO KW - Gene expression KW - Promoters KW - Cell death KW - Neural networks KW - Transcription factors KW - recombinase KW - Transgenes KW - Drosophila KW - W 30925:Genetic Engineering KW - N3 11007:Neurobiology KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Refined+Spatial+Manipulation+of+Neuronal+Function+by+Combinatorial+Restriction+of+Transgene+Expression&rft.au=Luan%2C+Haojiang%3BPeabody%2C+Nathan+C%3BVinson%2C+Charles+R%3BWhite%2C+Benjamin+H&rft.aulast=Luan&rft.aufirst=Haojiang&rft.date=2006-11-01&rft.volume=52&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/10.1016%2Fj.neuron.2006.08.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Promoters; Cell death; Neural networks; recombinase; Transcription factors; Transgenes; Drosophila DO - http://dx.doi.org/10.1016/j.neuron.2006.08.028 ER - TY - JOUR T1 - Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis, Structural Features, and Relative Activities AN - 19931518; 7119341 AB - Recently, using structure-inspired drug design, we demonstrated that aminoalkyl derivatives of {szligbeta}-cyclodextrin inhibited anthrax lethal toxin action by blocking the transmembrane pore formed by the protective antigen (PA) subunit of the toxin. In the present study, we evaluate a series of new {szligbeta}-cyclodextrin derivatives with the goal of identifying potent inhibitors of anthrax toxins. Newly synthesized hepta-6-thioaminoalkyl and hepta-6-thioguanidinoalkyl derivatives of {szligbeta}-cyclodextrin with alkyl spacers of various lengths were tested for the ability to inhibit cytotoxicity of lethal toxin in cells as well as to block ion conductance through PA channels reconstituted in planar bilayer lipid membranes. Most of the tested derivatives were protective against anthrax lethal toxin action at low or submicromolar concentrations. They also blocked ion conductance through PA channels at concentrations as low as 0.1 nM. The activities of the derivatives in both cell protection and channel blocking were found to depend on the length and chemical nature of the substituent groups. One of the compounds was also shown to block the edema toxin activity. It is hoped that these results will help to identify a new class of drugs for anthrax treatment, i.e., drugs that block the pathway for toxin translocation into the cytosol, the PA channel. JF - Antimicrobial Agents & Chemotherapy AU - Karginov, Vladimir A AU - Nestorovich, Ekaterina M AU - Yohannes, Adiamseged AU - Robinson, Tanisha M AU - Fahmi, Nour Eddine AU - Schmidtmann, Frank AU - Hecht, Sidney M AU - Bezrukov, Sergey M AD - Innovative Biologics, Inc., 10900 University Blvd., Manassas, Virginia 20110. Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20982. Pinnacle Pharmaceuticals, Inc., Emerging Technology Center One, 1670 Discovery Dr., Charlottesville, Virginia 22911. Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3740 EP - 3753 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 11 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Anthrax lethal toxin KW - Channel pores KW - Conductance KW - protective antigen KW - Edema KW - Drug development KW - Spacer KW - Antimicrobial agents KW - Cytotoxicity KW - Lipid membranes KW - Cytosol KW - Anthrax KW - Translocation KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19931518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Search+for+Cyclodextrin-Based+Inhibitors+of+Anthrax+Toxins%3A+Synthesis%2C+Structural+Features%2C+and+Relative+Activities&rft.au=Karginov%2C+Vladimir+A%3BNestorovich%2C+Ekaterina+M%3BYohannes%2C+Adiamseged%3BRobinson%2C+Tanisha+M%3BFahmi%2C+Nour+Eddine%3BSchmidtmann%2C+Frank%3BHecht%2C+Sidney+M%3BBezrukov%2C+Sergey+M&rft.aulast=Karginov&rft.aufirst=Vladimir&rft.date=2006-11-01&rft.volume=50&rft.issue=11&rft.spage=3740&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Conductance; Channel pores; protective antigen; Edema; Spacer; Drug development; Antimicrobial agents; Cytotoxicity; Lipid membranes; Cytosol; Anthrax; Drugs; Translocation ER - TY - JOUR T1 - Connecting genes, drugs and diseases AN - 19853731; 7333135 AB - A large-scale chemical genetic approach for systematically linking gene expression profiles with compounds and phenotypes offers promise for both basic and applied biomedical research. JF - Nature Biotechnology AU - Weinstein, J N AU - Pommier, Y AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Building 37, Room 5068, 37 Convent Drive, Bethesda, Maryland 20892, USA, weinstein@dtpax2.ncifcrf.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1365 EP - 1366 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 11 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Phenotypes KW - Drugs KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19853731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIAID+Awards+%244+Million+to+Develop+Anti-Radiation+Treatments&rft.au=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aulast=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Drugs; Phenotypes DO - http://dx.doi.org/10.1038/nbt1106-1365 ER - TY - JOUR T1 - Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or Obese Subjects AN - 19848666; 7122098 AB - Glucosamine is a popular nutritional supplement used to treat osteoarthritis. Intravenous administration of glucosamine causes insulin resistance and endothelial dysfunction. However, rigorous clinical studies evaluating the safety of oral glucosamine with respect to metabolic and cardiovascular pathophysiology are lacking. Therefore, we conducted a randomized, placebo-controlled, double-blind, crossover trial of oral glucosamine at standard doses (500 mg p.o. t.i.d.) in lean (n = 20) and obese (n = 20) subjects. Glucosamine or placebo treatment for 6 weeks was followed by a 1-week washout and crossover to the other arm. At baseline, and after each treatment period, insulin sensitivity was assessed by hyperinsulinemic-isoglycemic glucose clamp (SI sub(Clamp)) and endothelial function evaluated by brachial artery blood flow (BAF; Doppler ultrasound) and forearm skeletal muscle microvascular recruitment (ultrasound with microbubble contrast) before and during steady-state hyperinsulinemia. Plasma glucosamine pharmacokinetics after oral dosing were determined in each subject using a high-performance liquid chromatography method. As expected, at baseline, obese subjects had insulin resistance and endothelial dysfunction when compared with lean subjects (SI sub(Clamp) [median {25th-75th percentile}] = 4.3 [2.9-5.3] vs. 7.3 [5.7-11.3], P < 0.0001; insulin-stimulated changes in BAF [% over basal] = 12 [-6 to 84] vs. 39 [2-108], P < 0.04). When compared with placebo, glucosamine did not cause insulin resistance or endothelial dysfunction in lean subjects or significantly worsen these findings in obese subjects. The half-life of plasma glucosamine after oral dosing was similar to 150 min, with no significant changes in steady-state glucosamine levels detectable after 6 weeks of therapy. We conclude that oral glucosamine at standard doses for 6 weeks does not cause or significantly worsen insulin resistance or endothelial dysfunction in lean or obese subjects. JF - Diabetes AU - Muniyappa, Ranganath AU - Karne, Rajaram J AU - Hall, Gail AU - Crandon, Sonja K AU - Bronstein, Joel A AU - Ver, Maria R AU - Hortin, Glen L AU - Quon, Michael J AD - Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3142 EP - 3150 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA, [mailto:customerservice@diabetes.org], [URL:http://www.diabetes.org] VL - 55 IS - 11 SN - 0012-1797, 0012-1797 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Obesity KW - Microvasculature KW - Intravenous administration KW - Doppler effect KW - Osteoarthritis KW - Arteries KW - Glucosamine KW - Recruitment KW - Glucose KW - Hyperinsulinemia KW - Clinical trials KW - Insulin KW - Pharmacokinetics KW - Diabetes mellitus KW - Dietary supplements KW - Skeletal muscle KW - Ultrasound KW - Forearm KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Oral+Glucosamine+for+6+Weeks+at+Standard+Doses+Does+Not+Cause+or+Worsen+Insulin+Resistance+or+Endothelial+Dysfunction+in+Lean+or+Obese+Subjects&rft.au=Muniyappa%2C+Ranganath%3BKarne%2C+Rajaram+J%3BHall%2C+Gail%3BCrandon%2C+Sonja+K%3BBronstein%2C+Joel+A%3BVer%2C+Maria+R%3BHortin%2C+Glen+L%3BQuon%2C+Michael+J&rft.aulast=Muniyappa&rft.aufirst=Ranganath&rft.date=2006-11-01&rft.volume=55&rft.issue=11&rft.spage=3142&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Microvasculature; Obesity; Intravenous administration; Osteoarthritis; Doppler effect; Glucosamine; Arteries; Recruitment; Glucose; Hyperinsulinemia; Clinical trials; Pharmacokinetics; Insulin; Diabetes mellitus; Dietary supplements; Skeletal muscle; Ultrasound; Forearm ER - TY - JOUR T1 - Experience with experimental biological treatment and local gene therapy in Sjoegren's syndrome: implications for exocrine pathogenesis and treatment AN - 19847701; 7120260 AB - Sjoegren's syndrome is an autoimmune exocrinopathy, mainly affecting the lacrimal and salivary glands, and resulting in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown, and only palliative treatment is currently available. Data obtained from experimental animal and human studies using biological agents or gene therapeutics can offer insight into the disease process of Sjoegren's syndrome. This article reviews the current literature on these approaches and assesses the lessons learnt about the pathogenesis of Sjoegren's syndrome. JF - Annals of the Rheumatic Diseases AU - Lodde, B M AU - Baum, B J AU - Tak, P P AU - Illei, G AD - Gene Therapy and Therapeutics Branch/NIDCR, National Institutes of Health, DHHS, Bethesda, Maryland, USA. Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1406 EP - 1413 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 11 SN - 0003-4967, 0003-4967 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Sjogren's syndrome KW - Data processing KW - Gene therapy KW - Salivary gland KW - Keratoconjunctivitis KW - xerostomia KW - G 07720:Immunogenetics KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+Rheumatic+Diseases&rft.atitle=Experience+with+experimental+biological+treatment+and+local+gene+therapy+in+Sjoegren%27s+syndrome%3A+implications+for+exocrine+pathogenesis+and+treatment&rft.au=Lodde%2C+B+M%3BBaum%2C+B+J%3BTak%2C+P+P%3BIllei%2C+G&rft.aulast=Lodde&rft.aufirst=B&rft.date=2006-11-01&rft.volume=65&rft.issue=11&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+Rheumatic+Diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Data processing; Gene therapy; Salivary gland; Keratoconjunctivitis; xerostomia ER - TY - JOUR T1 - Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors AN - 19845016; 7385838 AB - Antiangiogenic gene therapy is a promising strategy for cancer treatment, which generally requires highly efficient delivery systems. To date, success of this strategy has depended almost exclusively on the delivery of high titers of viral vectors, which can result in effective transgene expression. However, their cytotoxicity and immunogenicity are a major concern for clinical applications. Recent advances in delivery efficiency of naked DNA could potentially meet the requirement for both high transgene expression and minimal side effects. To investigate whether naked DNA can be used for antiangiogenic cancer therapy, an expression plasmid was generated that encodes a soluble form of fetal liver kinase-1 (Flk-1) gene, a receptor for vascular endothelial growth factor (VEGF). Hydrodynamic injection of this plasmid resulted in close to 0.1 mg/ml of soluble Flk-1 protein in mouse serum and blocked VEGF-driven angiogenesis in matrigel in vivo. The same delivery significantly suppressed the growth of two different pre-existing subcutaneous tumors, Renca renal cell carcinoma and 3LL lung carcinoma. CD31 immunohistochemistry revealed that the tumor-associated angiogenesis was also highly attenuated in soluble Flk-1- treated mice. Thus, expression of genes by hydrodynamics-based gene delivery of naked DNA appears to be a promising approach for antiangiogenic cancer gene therapy. JF - Cancer Gene Therapy AU - Yazawa, H AU - Murakami, T AU - Li, H-M AU - Back, T AU - Kurosaka, K AU - Suzuki, Y AU - Shorts, L AU - Akiyama, Y AU - Maruyama, K AU - Parsoneault, E AU - Wiltrout, R H AU - Watanabe, M AD - Laboratory of Experimental Immunology, NCI Center for Cancer Research, Frederick, MD, USA, watanabm@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 993 EP - 1001 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 13 IS - 11 SN - 0929-1903, 0929-1903 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - hydrodynamics-based gene delivery KW - VEGF KW - Flk-1 KW - angiogenesis KW - renal cell carcinoma KW - lung carcinoma KW - Vascular endothelial growth factor KW - vascular endothelial growth factor receptor 2 KW - Hydrodynamics KW - Gene therapy KW - Lung carcinoma KW - Angiogenesis KW - Therapeutic applications KW - Tumors KW - Plasmids KW - Expression vectors KW - Cytotoxicity KW - Immunogenicity KW - Gene transfer KW - DNA KW - Vascular endothelial growth factor receptor 2 KW - Immunohistochemistry KW - Side effects KW - W 30905:Medical Applications KW - V 22350:Immunology KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19845016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Hydrodynamics-based+gene+delivery+of+naked+DNA+encoding+fetal+liver+kinase-1+gene+effectively+suppresses+the+growth+of+pre-existing+tumors&rft.au=Yazawa%2C+H%3BMurakami%2C+T%3BLi%2C+H-M%3BBack%2C+T%3BKurosaka%2C+K%3BSuzuki%2C+Y%3BShorts%2C+L%3BAkiyama%2C+Y%3BMaruyama%2C+K%3BParsoneault%2C+E%3BWiltrout%2C+R+H%3BWatanabe%2C+M&rft.aulast=Yazawa&rft.aufirst=H&rft.date=2006-11-01&rft.volume=13&rft.issue=11&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fsj.cgt.7700970 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; vascular endothelial growth factor receptor 2; Gene therapy; Hydrodynamics; Lung carcinoma; Angiogenesis; Therapeutic applications; Tumors; Plasmids; Expression vectors; Cytotoxicity; renal cell carcinoma; Gene transfer; Immunogenicity; DNA; Vascular endothelial growth factor receptor 2; Immunohistochemistry; Side effects DO - http://dx.doi.org/10.1038/sj.cgt.7700970 ER - TY - JOUR T1 - Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes AN - 19844723; 7106728 AB - Aims: Microbial invasion of the amniotic cavity (MIAC) elicits a fetal inflammatory response such as funisitis and chorionic vasculitis. However, little is known about the changes of fetal skin during MIAC. Toll-like receptors recognize microbial products and initiate an immune response. The aims of this study were to examine histopathological features of fetal skin exposed to MIAC and to assess the changes in Toll-like receptor (TLR)-2 and TLR-4 expression. Methods and results: Skin samples were obtained from fetal autopsies (n = 12). The cases were classified according to the presence (n = 8) or absence (n = 4) of acute chorioamnionitis and analysed by immunohistochemistry using a panel of antibodies. Leucocytic infiltrates into the superficial dermis were observed in cases with chorioamnionitis; the majority of inflammatory cells were neutrophils, lymphocytes and histiocytes. TLR-2 immunoreactivity in the skin was stronger in fetuses with chorioamnionitis than in those without this condition. However, immunoreactivity of TLR-4 in the fetal skin was constitutively expressed, regardless of the presence or absence of chorioamnionitis. Conclusions: This study demonstrates for the first time that fetal dermatitis can be detected and is part of the fetal inflammatory response syndrome (FIRS). We propose that this 'FIRS-associated fetal dermatitis' is a fetal counterpart of chorioamnionitis. JF - Histopathology AU - Kim, Y M AU - Romero, R AU - Chaiworapongsa, T AU - Espinoza, J AU - Mor, G AU - Kim, C J AD - Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD and Detroit, MI Center for Molecular Medicine and Genetics, warfiela@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 506 EP - 514 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 49 IS - 5 SN - 0309-0167, 0309-0167 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cavities KW - Autopsy KW - Dermis KW - Vasculitis KW - Skin KW - TLR2 protein KW - Leukocytes (neutrophilic) KW - Lymphocytes KW - Fetuses KW - Inflammation KW - Antibodies KW - Chorioamnionitis KW - Immune response KW - Keratinocytes KW - Immunohistochemistry KW - Toll-like receptors KW - Dermatitis KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Histopathology&rft.atitle=Dermatitis+as+a+component+of+the+fetal+inflammatory+response+syndrome+is+associated+with+activation+of+Toll-like+receptors+in+epidermal+keratinocytes&rft.au=Kim%2C+Y+M%3BRomero%2C+R%3BChaiworapongsa%2C+T%3BEspinoza%2C+J%3BMor%2C+G%3BKim%2C+C+J&rft.aulast=Kim&rft.aufirst=Y&rft.date=2006-11-01&rft.volume=49&rft.issue=5&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Histopathology&rft.issn=03090167&rft_id=info:doi/10.1111%2Fj.1365-2559.2006.02542.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - SuppNotes - Figures, 4; tables, 2; references, 31. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Autopsy; Cavities; Dermis; Skin; Vasculitis; TLR2 protein; Leukocytes (neutrophilic); Lymphocytes; Fetuses; Inflammation; Antibodies; Chorioamnionitis; Keratinocytes; Immune response; Immunohistochemistry; Toll-like receptors; Dermatitis DO - http://dx.doi.org/10.1111/j.1365-2559.2006.02542.x ER - TY - JOUR T1 - Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice AN - 19838459; 7167020 AB - We developed a genetic mouse model of open-angle glaucoma by expression of mutated mouse myocilin (Myoc) in transgenic (Tg) mice. The Tyr423His point mutation, corresponding to the severe glaucoma-causing Tyr437His mutation in the human MYOC gene, was introduced into bacterial artificial chromosome DNA encoding the full-length mouse Myoc gene and long flanking regions. Both wild-type (Wt) and Tg animals expressed Myoc in tissues of the irido-corneal angle and the sclera. Expression of mutated Myoc induced the accumulation of Myoc in cell cytoplasm and prevented its secretion into the extracellular space. The levels of ATPase-1 were reduced in the irido-corneal angle of Tg mice compared with Wt animals. Tg mice demonstrated a moderate elevation of intraocular pressure, the loss of similar to 20% of the retinal ganglion cells (RGCs) in the peripheral retina, and axonal degeneration in the optic nerve. RGC depletion was associated with the shrinkage of their nuclei and DNA fragmentation in the peripheral retina. Pathological changes observed in the eyes of Tg mice are similar to those observed in glaucoma patients. JF - Journal of Neuroscience AU - Senatorov, Vladimir AU - Malyukova, Irina AU - Fariss, Robert AU - Wawrousek, Eric F AU - Swaminathan, Srividya AU - Sharan, Shyam K AU - Tomarev, Stanislav AD - Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, and Biological Imaging Core, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, and Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 11903 EP - 11914 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 46 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Retina KW - Retinal ganglion cells KW - Secretion KW - Point mutation KW - Animal models KW - MYOC gene KW - Transgenic mice KW - Neurodegeneration KW - Optic nerve KW - Bacterial artificial chromosomes KW - DNA fragmentation KW - Nervous system KW - Glaucoma KW - Cytoplasm KW - Atrophy KW - Pressure KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - N3 11004:Motor & sensory systems KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Expression+of+Mutated+Mouse+Myocilin+Induces+Open-Angle+Glaucoma+in+Transgenic+Mice&rft.au=Senatorov%2C+Vladimir%3BMalyukova%2C+Irina%3BFariss%2C+Robert%3BWawrousek%2C+Eric+F%3BSwaminathan%2C+Srividya%3BSharan%2C+Shyam+K%3BTomarev%2C+Stanislav&rft.aulast=Senatorov&rft.aufirst=Vladimir&rft.date=2006-11-01&rft.volume=26&rft.issue=46&rft.spage=11903&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Retina; Retinal ganglion cells; Secretion; Point mutation; Animal models; MYOC gene; Transgenic mice; Neurodegeneration; Bacterial artificial chromosomes; Optic nerve; DNA fragmentation; Nervous system; Glaucoma; Cytoplasm; Atrophy; Pressure ER - TY - JOUR T1 - Derivation of an In Vivo Drug Exposure Breakpoint for Flucytosine against Candida albicans and Impact of the MIC, Growth Rate, and Resistance Genotype on the Antifungal Effect AN - 19838169; 7119333 AB - Drug exposure or pharmacodynamic breakpoints refer to a magnitude of drug exposure which separates a population into groups with high and low probabilities of attaining a desired outcome. We used a pharmacodynamic model of disseminated candidiasis to define an in vivo drug exposure breakpoint for flucytosine (5FC) against Candida albicans. The results were bridged to humans by using population pharmacokinetics and Monte Carlo simulation. An in vivo drug exposure breakpoint for 5FC was apparent when serum levels were above the MIC for 45% of the dosing interval. The Monte Carlo simulations suggested that using a human dose of 100 mg/kg of body weight/day in four divided doses, 5FC resistance was defined at an MIC of 32 mg/liter. Target attainment rates following administration of 25, 50, and 100 mg/kg/day were similar, suggesting that the use of a lower dose of 5FC is possible. Using six isolates of C. albicans with MICs ranging from 0.06 to >64 mg/liter, we also explored the influence that the MIC, the fraction of the dosing interval that the serum levels of 5FC remained above the MIC (T>MIC), the 5FC resistance genotype, and the in vivo growth rate had on the response to 5FC. The MIC and T>MIC were both critical measures affecting the generation of a drug effect but had no bearing on the magnitude of the maximal kill induced by 5FC. The in vivo growth rate was a critical additional determinant of the exposure-response relationship. There was a relationship between the 5FC resistance genotype and the exposure-response relationship. JF - Antimicrobial Agents & Chemotherapy AU - Hope, William W AU - Warn, Peter A AU - Sharp, Andrew AU - Howard, Susan AU - Kasai, Miki AU - Louie, Arnold AU - Walsh, Thomas J AU - Drusano, George L AU - Denning, David W AD - School of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom. Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., Bethesda, Maryland 20892. Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208. Wythenshawe Hospital, Southmoor Rd., Manchester, M23 9LT, United Kingdom Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3680 EP - 3688 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Monte Carlo simulation KW - Growth rate KW - Candidiasis KW - Candida albicans KW - Genotypes KW - Minimum inhibitory concentration KW - Pharmacokinetics KW - flucytosine KW - Models KW - Antimicrobial agents KW - Serum levels KW - Breakpoints KW - Body weight KW - Dose-response effects KW - Drugs KW - Pharmacodynamics KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Derivation+of+an+In+Vivo+Drug+Exposure+Breakpoint+for+Flucytosine+against+Candida+albicans+and+Impact+of+the+MIC%2C+Growth+Rate%2C+and+Resistance+Genotype+on+the+Antifungal+Effect&rft.au=Hope%2C+William+W%3BWarn%2C+Peter+A%3BSharp%2C+Andrew%3BHoward%2C+Susan%3BKasai%2C+Miki%3BLouie%2C+Arnold%3BWalsh%2C+Thomas+J%3BDrusano%2C+George+L%3BDenning%2C+David+W&rft.aulast=Hope&rft.aufirst=William&rft.date=2006-11-01&rft.volume=50&rft.issue=11&rft.spage=3680&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Growth rate; Monte Carlo simulation; Candidiasis; Genotypes; Minimum inhibitory concentration; flucytosine; Pharmacokinetics; Antimicrobial agents; Models; Serum levels; Breakpoints; Body weight; Dose-response effects; Drugs; Pharmacodynamics; Candida albicans ER - TY - JOUR T1 - Cytoplasmic Targeting Motifs Control Localization of Toll-like Receptor 9 AN - 19835784; 7166544 AB - Toll-like receptors (TLRs) are essential for host defense. Although several TLRs reside on the cell surface, nucleic acid recognition of TLRs occurs intracellularly. For example, the receptor for CpG containing bacterial and viral DNA, TLR9, is retained in the endoplasmic reticulum. Recent evidence suggests that the localization of TLR9 is critical for appropriate ligand recognition. Here we have defined which structural features of the TLR9 molecule control its intracellular localization. Both the cytoplasmic and ectodomains of TLR9 contain sufficient information, whereas the transmembrane domain plays no role in intracellular localization. We identify a 14-amino acid stretch that directs TLR9 intracellularly and confers intracellular localization to the normally cell surface-expressed TLR4. Truncation or mutation of the cytoplasmic tail of TLR9 reveals a vesicle localization motif that targets early endosomes. We propose a model whereby modification of the cytoplasmic tail of TLR9 results in trafficking to early endosomes where it encounters CpG DNA. JF - Journal of Biological Chemistry AU - Leifer, Cynthia A AU - Brooks, James C AU - Hoelzer, Karin AU - Lopez, Jody AU - Kennedy, Margaret N AU - Mazzoni, Alessandra AU - Segal, David M AD - Cornell University College of Veterinary Medicine, Ithaca, New York 14853 and Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892-1360 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 35585 EP - 35592 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 46 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Cell surface KW - Protein transport KW - TLR9 protein KW - CpG islands KW - Transmembrane domains KW - Endoplasmic reticulum KW - endosomes KW - nucleic acids KW - Vesicles KW - TLR4 protein KW - Mutation KW - Toll-like receptors KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19835784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cytoplasmic+Targeting+Motifs+Control+Localization+of+Toll-like+Receptor+9&rft.au=Leifer%2C+Cynthia+A%3BBrooks%2C+James+C%3BHoelzer%2C+Karin%3BLopez%2C+Jody%3BKennedy%2C+Margaret+N%3BMazzoni%2C+Alessandra%3BSegal%2C+David+M&rft.aulast=Leifer&rft.aufirst=Cynthia&rft.date=2006-11-01&rft.volume=281&rft.issue=46&rft.spage=35585&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Cell surface; Endoplasmic reticulum; endosomes; nucleic acids; TLR9 protein; Vesicles; CpG islands; Transmembrane domains; Mutation; TLR4 protein; Toll-like receptors ER - TY - JOUR T1 - Long-term safety of cardiac magnetic resonance imaging performed in the first few days after bare-metal stent implantation AN - 19685070; 7459268 AB - To investigate the long-term safety of cardiac magnetic resonance imaging (CMR) performed one to seven days after coronary artery stent (bare metal) implantation. We analyzed 119 consecutive patients with acute myocardial infarction (MI) who underwent emergency coronary stent implantation with a bare- metal stent. CMR using a 1.5T scanner was performed on 51 patients (42.9%) at a mean of 2.7 +/- 3.1 days after stent implantation (CMR+ group), and the remaining 68 patients (57.1%) served as controls (CMR- group). The patients were followed up to six months for major adverse cardiac events. The average stent size was 3.3 +/- 0.5 X 18.4 +/- 6.7 mm, and 86% of the stents were made of 316L stainless steel. There were no significant differences between the CMR+ and CMR- groups in terms of infarct features, angiographic findings, or stent characteristics. Over a mean follow-up of 4.4 +/- 2.1 months, 12 patients (10.1%) had 16 events (13.4%). Two patients had adverse events after early MRI scan (4.3%), a rate that is lower than the event rate in the patients who did not undergo MRI (16%, P = 0.04), and one of the two events was clearly not MRI related. CMR on a 1.5T scanner can be safely performed within one to seven days after coronary bare-metal stent implantation and is not associated with an increased risk of adverse clinical cardiac outcomes. In the light of accumulating data, the guidelines by stent manufacturers should be revised. J. Magn. Reson. Imaging 2006. JF - Journal of Magnetic Resonance Imaging AU - Syed, Mushabbar A AU - Carlson, Karen AU - Murphy, Mandy AU - Ingkanisorn, WPatricia AU - Rhoads, Kenneth L AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nhlbi.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1056 EP - 1061 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 24 IS - 5 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - magnetic resonance imaging KW - heart KW - safety KW - stent KW - myocardial infarction KW - Heart KW - Metals KW - Magnetic resonance imaging KW - Myocardial infarction KW - coronary artery KW - stainless steel KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19685070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Long-term+safety+of+cardiac+magnetic+resonance+imaging+performed+in+the+first+few+days+after+bare-metal+stent+implantation&rft.au=Syed%2C+Mushabbar+A%3BCarlson%2C+Karen%3BMurphy%2C+Mandy%3BIngkanisorn%2C+WPatricia%3BRhoads%2C+Kenneth+L%3BArai%2C+Andrew+E&rft.aulast=Syed&rft.aufirst=Mushabbar&rft.date=2006-11-01&rft.volume=24&rft.issue=5&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20740 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Metals; Magnetic resonance imaging; Myocardial infarction; stainless steel; coronary artery DO - http://dx.doi.org/10.1002/jmri.20740 ER - TY - JOUR T1 - The Mortality Risk of Smoking and Obesity Combined AN - 19657012; 8791141 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Freedman, D Michal AU - Sigurdson, Alice J AU - Rajaraman, Preetha AU - Doody, Michele M AU - Linet, Martha S AU - Ron, Elaine AD - National Cancer Institute, Division of Epidemiology and Genetics, Bethesda, Maryland, mf101e@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 355 EP - 362 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 31 IS - 5 SN - 0749-3797, 0749-3797 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - Obesity KW - Death KW - obesity KW - Smoking KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19657012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Mortality+Risk+of+Smoking+and+Obesity+Combined&rft.au=Freedman%2C+D+Michal%3BSigurdson%2C+Alice+J%3BRajaraman%2C+Preetha%3BDoody%2C+Michele+M%3BLinet%2C+Martha+S%3BRon%2C+Elaine&rft.aulast=Freedman&rft.aufirst=D&rft.date=2006-11-01&rft.volume=31&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2006.07.022 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Smoking; Death; Mortality; obesity DO - http://dx.doi.org/10.1016/j.amepre.2006.07.022 ER - TY - JOUR T1 - Overproduction, purification, and biochemical characterization of the dual specificity H1 protein phosphatase encoded by variola major virus AN - 19608431; 8586343 AB - Smallpox, a highly contagious infectious disease caused by the variola major virus, has an overall mortality rate of about 30%. Because there currently is no specific treatment for smallpox, and the only prevention is vaccination, there is an urgent need for the development of effective antiviral drugs. The dual specificity protein phosphatase encoded by the smallpox virus (H1) is essential for the production of infectious viral particles, making it a promising molecular target for antiviral therapeutics. Here, we report the molecular cloning, overproduction, purification, and initial biochemical characterization of H1 phosphatase, thereby paving the way for the discovery of small molecule inhibitors. JF - Protein Expression and Purification AU - Tropea, Joseph E AU - Phan, Jason AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD, USA, waughd@ncifcrf.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 31 EP - 36 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Smallpox KW - Variola major KW - Dual specificity phosphatase KW - H1 phosphatase KW - H1L KW - Mortality KW - Antiviral agents KW - Infectious diseases KW - Variola KW - Drug development KW - protein purification KW - protein phosphatase KW - Vaccination KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Overproduction%2C+purification%2C+and+biochemical+characterization+of+the+dual+specificity+H1+protein+phosphatase+encoded+by+variola+major+virus&rft.au=Tropea%2C+Joseph+E%3BPhan%2C+Jason%3BWaugh%2C+David+S&rft.aulast=Tropea&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smallpox; Mortality; Infectious diseases; Antiviral agents; Drug development; protein purification; Vaccination; protein phosphatase; Variola DO - http://dx.doi.org/10.1016/j.pep.2006.05.007 ER - TY - JOUR T1 - Production and characterization of clinical grade Escherichia coli derived Plasmodium falciparum 42 kDa merozoite surface protein 1 (MSP1 sub(42)) in the absence of an affinity tag AN - 19607894; 8586347 AB - The 42 kDa cleavage product from the carboxyl end of the Plasmodium falciparum merozoite surface protein 1 (MSP1 sub(42)) is an important blood-stage malaria vaccine target. Several recombinant protein expression systems have been used for production of MSP1 sub(42) including yeast (Saccharomyces cerevisiae and Pichia pastoris), Escherichia coli, baculovirus and transgenic animals. To date, all of the reported recombinant proteins include a 6x His affinity tag to facilitate purification, including three MSP1 sub(42) clinical grade proteins currently in human trials. Under some circumstances, the presence of the 6x His tag may not be desirable. Therefore, we were interested to produce clinical grade MSP1 sub(42) without a 6x His affinity tag from E. coli inclusion bodies. We produced a recombinant MSP1 sub(42) with a P. falciparum FUP (Uganda-Palo Alto) phenotype which accounts for a substantial proportion of the MSP1 sub(42) protein observed in African isolates. EcMSP1 sub(42)-FUP was produced in E. coli inclusion bodies by high cell mass induction with IPTG using 5 L and 60 L bioreactors. Isolated inclusion bodies were solubilized in 8 M guanidine-HCl and the EcMSP1 sub(42)-FUP protein refolded by rapid dilution. Refolded EcMSP1 sub(42)-FUP was purified using hydrophobic interaction chromatography, anion exchange chromatography, and size exclusion chromatography, and subject to biochemical characterization for integrity, identity, and purity. Endotoxin and host cell protein levels were within acceptable limits for human use. The process was successfully transferred to pilot-scale production in a cGMP environment. A final recovery of 87.8 mg of clinical-grade material per liter of fermentation broth was achieved. The EcMSP1 sub(42)-FUP clinical antigen is available for preclinical evaluation and human studies. JF - Protein Expression and Purification AU - Shimp, Richard L AU - Martin, Laura B AU - Zhang, Yanling AU - Henderson, Brian S AU - Duggan, Peter AU - MacDonald, Nicholas J AU - Lebowitz, Jacob AU - Saul, Allan AU - Narum, David L AD - Malaria Vaccine Development Branch (MVDB), NIAID/NIH/DHHS, Rockville, MD, USA, dnarum@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 58 EP - 67 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Analytical Methods KW - Africa KW - Proteins KW - protein purification KW - Baculovirus KW - AQ 00001:Water Resources and Supplies KW - J 02410:Animal Diseases KW - K 03330:Biochemistry KW - A 01490:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Production+and+characterization+of+clinical+grade+Escherichia+coli+derived+Plasmodium+falciparum+42+kDa+merozoite+surface+protein+1+%28MSP1+sub%2842%29%29+in+the+absence+of+an+affinity+tag&rft.au=Shimp%2C+Richard+L%3BMartin%2C+Laura+B%3BZhang%2C+Yanling%3BHenderson%2C+Brian+S%3BDuggan%2C+Peter%3BMacDonald%2C+Nicholas+J%3BLebowitz%2C+Jacob%3BSaul%2C+Allan%3BNarum%2C+David+L&rft.aulast=Shimp&rft.aufirst=Richard&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - protein purification; Proteins; Baculovirus; Africa DO - http://dx.doi.org/10.1016/j.pep.2006.06.018 ER - TY - JOUR T1 - Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus Kurz AN - 19586398; 7305088 AB - We previously observed that rhinacanthins-C, -N and -Q, three main naphthoquinone esters isolated from the roots of Thai medicinal plant; Rhinacanthus nasutus Kurz. (Acanthaceae) induced apoptosis of human cervical carcinoma HeLaS3 cells. Since these rhinacanthins showed limited solubility in aqueous medium, we attempted to entrap them into liposomal membrane: Liposomalization enabled injection of the drugs and the drugs were expected to transfer to lipoproteins in the bloodstream. Liposomal formulations of rhinacanthins-C, -N and -Q showed strong antiproliferative activity against HeLaS3 cells with the IC sub(50) values of 32,17, 70 mu M; 19, 17, 52 mu m and 2.7, 2.0 and 5.0 mu M for the exposure time of 24, 48, and 72 h, respectively. These liposomes suppressed the tumor growth in Meth-A sarcoma-bearing BALB/c mice at the dose of 5.0 mg/kg/d for 10 d. Among rhinacanthins, liposomal rhinacanthin-N significantly suppressed solid tumor growth. Based on these results, our findings demonstrated that rhinacanthin-N suppressed tumor growth in vivo, and suggested that liposomes are useful for preparing injectable formulation of hydrophobic drugs. JF - Biological & Pharmaceutical Bulletin AU - Siripong, P AU - Yahuafai, J AU - Shimizu, K AU - Ichikawa, K AU - Yonezawa, S AU - Asai, T AU - Kanokmedakul, K AU - Ruchirawat, S AU - Oku, N AD - Natural Products Research Section, Research Division, National Cancer Institute; Bangkok 10400, Thailand, Oku@u-shizuoka-ken.ac.jp Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2279 EP - 2283 VL - 29 IS - 11 SN - 0918-6158, 0918-6158 KW - Acanthus KW - Biotechnology and Bioengineering Abstracts KW - Cervical carcinoma KW - Solubility KW - Apoptosis KW - Solid tumors KW - Medicinal plants KW - Hydrophobicity KW - Tumors KW - Acanthaceae KW - Esters KW - Liposomes KW - Lipoproteins KW - Rhinacanthus nasutus KW - Drugs KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19586398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+%26+Pharmaceutical+Bulletin&rft.atitle=Antitumor+Activity+of+Liposomal+Naphthoquinone+Esters+Isolated+from+Thai+Medicinal+Plant%3A+Rhinacanthus+nasutus+Kurz&rft.au=Siripong%2C+P%3BYahuafai%2C+J%3BShimizu%2C+K%3BIchikawa%2C+K%3BYonezawa%2C+S%3BAsai%2C+T%3BKanokmedakul%2C+K%3BRuchirawat%2C+S%3BOku%2C+N&rft.aulast=Siripong&rft.aufirst=P&rft.date=2006-11-01&rft.volume=29&rft.issue=11&rft.spage=2279&rft.isbn=&rft.btitle=&rft.title=Biological+%26+Pharmaceutical+Bulletin&rft.issn=09186158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cervical carcinoma; Apoptosis; Solubility; Solid tumors; Lipoproteins; Medicinal plants; Hydrophobicity; Tumors; Esters; Liposomes; Drugs; Antitumor activity; Rhinacanthus nasutus; Acanthaceae ER - TY - JOUR T1 - Granulibacter bethesdensis gen. nov., sp. nov., a distinctive pathogenic acetic acid bacterium in the family Acetobacteraceae AN - 19556214; 7271383 AB - A Gram-negative, aerobic, coccobacillus to rod-shaped bacterium was isolated from three patients with chronic granulomatous disease. The organism was subjected to a polyphasic taxonomic study. A multilocus phylogenetic analysis based on the 16S rRNA gene, the internal transcribed spacer (ITS) region and the RecA protein demonstrated that the organism belongs to a new sublineage within the acetic acid bacteria in the family Acetobacteraceae. Phenotypic features are summarized as follows: the organism grew at an optimum temperature of 35-37 not equal to and optimum pH of 5.0-6.5. It produced a yellow pigment, oxidized lactate and acetate, the latter weakly, produced little acetic acid from ethanol and could use methanol as a sole carbon source. The two major fatty acids were a straight-chain unsaturated acid (C18 : 1[omega]7c) and C16 : 0. The DNA base composition was 59.1 mol% G+C. The very weak production of acetic acid from ethanol, the ability to use methanol, the yellow pigmentation and high optimum temperature for growth distinguished this organism from other acetic acid bacteria. The unique phylogenetic and phenotypic characteristics suggest that the bacterium should be classified within a separate genus, for which the name Granulibacter bethesdensis gen. nov., sp. nov. is proposed. The type strain is CGDNIH1 super(T) (=ATCC BAA-1260 super(T)=DSM 17861 super(T)). JF - International Journal of Systematic and Evolutionary Microbiology AU - Greenberg, David E AU - Porcella, Stephen F AU - Stock, Frida AU - Wong, Alexandra AU - Conville, Patricia S AU - Murray, Patrick R AU - Holland, Steven M AU - Zelazny, Adrian M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, US Department of Health and Human Services, Bethesda, MD 20892, USA, degreenberg@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2609 EP - 2616 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 56 IS - 11 SN - 1466-5026, 1466-5026 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Temperature effects KW - Pigmentation KW - Methanol KW - Carbon sources KW - Base composition KW - Pigments KW - Lactic acid KW - Fatty acids KW - DNA KW - Acetic acid bacteria KW - Chronic granulomatous disease KW - rRNA 16S KW - pH effects KW - RecA protein KW - Ethanol KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19556214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.atitle=Granulibacter+bethesdensis+gen.+nov.%2C+sp.+nov.%2C+a+distinctive+pathogenic+acetic+acid+bacterium+in+the+family+Acetobacteraceae&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BStock%2C+Frida%3BWong%2C+Alexandra%3BConville%2C+Patricia+S%3BMurray%2C+Patrick+R%3BHolland%2C+Steven+M%3BZelazny%2C+Adrian+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2006-11-01&rft.volume=56&rft.issue=11&rft.spage=2609&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.issn=14665026&rft_id=info:doi/10.1099%2Fijs.0.64412-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Phylogeny; Pigmentation; Methanol; Carbon sources; Base composition; Pigments; DNA; Fatty acids; Lactic acid; Acetic acid bacteria; Chronic granulomatous disease; pH effects; rRNA 16S; RecA protein; Ethanol DO - http://dx.doi.org/10.1099/ijs.0.64412-0 ER - TY - JOUR T1 - Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function AN - 19543544; 7168612 AB - Despite sharing little sequence identity, most type III chaperones display a similar homodimeric structure characterized by negative charges distributed broadly over their entire surface, interspersed with hydrophobic patches. Here we have used SigE from Salmonella as a model for class IA type III chaperones to investigate the role of these surface-exposed residues in chaperone function. SigE is essential for the stability, secretion and translocation of its cognate effector, SopB (SigD). We analysed the effect of mutating nine conserved hydrophobic and electronegative surface-exposed amino acids of SigE on SopB binding, stability, secretion and translocation. Six of these mutations affected some aspect of SigE function (Leu14, Asp20, Leu22, Leu23, Ile25 and Asp51) and three were without effect (Leu54, Glu92 and Glu99). Our results highlight that both hydrophobic and electronegative surfaces are required for the function of SigE and provide an important basis for the prediction of side-chain requirements for other chaperone-effector pairs. JF - Molecular Microbiology AU - Knodler, Leigh A AU - Bertero, Michela AU - Yip, Calvin AU - Strynadka, Natalie CJ AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA, lknodler@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 928 EP - 940 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 62 IS - 4 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Amino acids KW - Hydrophobicity KW - Chaperones KW - Salmonella KW - Translocation KW - Mutation KW - Mutagenesis KW - Models KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19543544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure-based+mutagenesis+of+SigE+verifies+the+importance+of+hydrophobic+and+electrostatic+residues+in+type+III+chaperone+function&rft.au=Knodler%2C+Leigh+A%3BBertero%2C+Michela%3BYip%2C+Calvin%3BStrynadka%2C+Natalie+CJ%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2006-11-01&rft.volume=62&rft.issue=4&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05418.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 5; tables, 3; references, 58. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acids; Chaperones; Hydrophobicity; Mutation; Translocation; Models; Mutagenesis; Salmonella DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05418.x ER - TY - JOUR T1 - Platelet activation, upregulation of CDllb/CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smoke AN - 19504323; 7194793 AB - The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta sub(2) Mac-1 integrin (CDllb/CD18) expression on polymorphonuclear leukocytes (PMN) and monocytes, and P-selectin (CD62P) expression on the platelets of 165 women from eastern India, who cook solely with wood, dung and agricultural wastes, and 155 age- and socio-economic condition-matched control subjects, who used relatively cleaner fuel, liquefied petroleum gas (LPG). Leukocyte-platelet aggregates were defined as CD11b-positive PMN and monocytes co-expressing platelet-specific markers CD41 or CD62P. A significant increase in leukocyte-platelet aggregates was found in women who used biomass as cooking fuel. In addition, they showed increased surface expression of CDllb/CD18 in circulating PMN and monocytes and CD62P expression on platelets. The mean fluorescence intensity (MFI) of CD11b on the surface of circulating monocytes and PMN of biomass users increased by 50 and 68%, respectively. Similarly, a 62 and 48% increase in MFI was observed in CD18 expression on the surface of these cells in biomass users. The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis. JF - Human & Experimental Toxicology AU - Ray, M R AU - Mukherjee, S AU - Roychoudhury, S AU - Bhattacharya, P AU - Banerjee, M AU - Siddique, S AU - Chakraborty, S AU - Lahiri, T AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute, 37, SP Mukherjee Road, Kolkata 700 026, India, manasrray@rediffmail.com Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 627 EP - 635 VL - 25 IS - 11 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Fluorescence KW - Fuels KW - Leukocytes (polymorphonuclear) KW - Agricultural wastes KW - Leukocytes KW - P-selectin KW - Biomass KW - CD18 antigen KW - Thrombosis KW - Cell activation KW - Flow cytometry KW - Smoke KW - Chronic exposure KW - Mac1 protein KW - Integrins KW - CD11b antigen KW - Energy KW - Petroleum KW - Risk factors KW - Cooking KW - Dung KW - Platelets KW - Monocytes KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19504323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Platelet+activation%2C+upregulation+of+CDllb%2FCD18+expression+on+leukocytes+and+increase+in+circulating+leukocyte-platelet+aggregates+in+Indian+women+chronically+exposed+to+biomass+smoke&rft.au=Ray%2C+M+R%3BMukherjee%2C+S%3BRoychoudhury%2C+S%3BBhattacharya%2C+P%3BBanerjee%2C+M%3BSiddique%2C+S%3BChakraborty%2C+S%3BLahiri%2C+T&rft.aulast=Ray&rft.aufirst=M&rft.date=2006-11-01&rft.volume=25&rft.issue=11&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327106074603 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fluorescence; Agricultural wastes; Leukocytes (polymorphonuclear); Fuels; Leukocytes; P-selectin; Biomass; CD18 antigen; Thrombosis; Cell activation; Smoke; Flow cytometry; Integrins; Mac1 protein; Chronic exposure; Risk factors; Petroleum; Energy; CD11b antigen; Cooking; Platelets; Dung; Monocytes DO - http://dx.doi.org/10.1177/0960327106074603 ER - TY - JOUR T1 - Role of DNA Polymerase IV in Escherichia coli SOS Mutator Activity AN - 19471496; 7166359 AB - Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product). JF - Journal of Bacteriology AU - Kuban, Wojciech AU - Banach-Orlowska, Magdalena AU - Schaaper, Roel M AU - Jonczyk, Piotr AU - Fijalkowska, Iwona J AD - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02 106 Warsaw, Poland. Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 7977 EP - 7980 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 22 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - umuDC gene KW - dinB gene KW - DNA-directed DNA polymerase KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19471496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+DNA+Polymerase+IV+in+Escherichia+coli+SOS+Mutator+Activity&rft.au=Kuban%2C+Wojciech%3BBanach-Orlowska%2C+Magdalena%3BSchaaper%2C+Roel+M%3BJonczyk%2C+Piotr%3BFijalkowska%2C+Iwona+J&rft.aulast=Kuban&rft.aufirst=Wojciech&rft.date=2006-11-01&rft.volume=188&rft.issue=22&rft.spage=7977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - umuDC gene; dinB gene; DNA-directed DNA polymerase; Escherichia coli ER - TY - JOUR T1 - CT Colonography with Computer-aided Polyp Detection: Volume and Attenuation Thresholds to Reduce False-Positive Findings Owing to the Ileocecal Valve AN - 19464827; 7126607 AB - PURPOSE: To retrospectively identify volume and average attenuation thresholds for differentiating between ileocecal valve (ICV) and polyp at computed tomographic (CT) colonography with computer-aided detection (CAD). MATERIALS AND METHODS: Informed consent (with consent for future retrospective research) and institutional review board (IRB) approval were obtained for the original prospective study. This retrospective study had IRB approval, as well, and was HIPAA-compliant. A total of 496 patients were selected from a larger screening population. CT colonographic images from 394 patients (227 men, 167 women; mean age, 58.0 years; range, 40-79 years) were used as a training set, and images from 102 patients (76 men, 26 women; mean age, 59.8 years; range, 46-79 years) were used as a test set. A series of 2742 volume and attenuation thresholds, for which segmented findings both larger in volume and lower in average attenuation were labeled as ICVs and remaining findings were labeled polyps, were applied to the training set to determine settings with 100% sensitivity for polyp detection and the highest specificity for ICV detection. The optimal settings were then applied to the test set. Significance was assessed with the Fisher exact test, and 95% confidence intervals (CIs) were computed for sensitivity and specificity. RESULTS: A total of 386 ICVs and 67 adenomatous polyps from the training set and 102 ICVs and 138 adenomatous polyps from the test set could be segmented with a three-dimensional segmentation algorithm. When supine and prone images were counted individually, 746 nonunique ICVs from the training set and 191 from the test set were segmentable. In the training set, a volume of 600 mm super(3) and an attenuation of 36 HU provided 100% sensitivity (67 polyps; 95% CI: 93%, 100%) and the optimal 83% specificity (618 of 746 ICVs; 95% CI: 80%, 85%). When applied to the test set, this combination provided 97% sensitivity (134 of 138 polyps; 95% CI: 92%, 99%) and 84% specificity (160 of 191 ICVs; 95% CI: 78%, 89%). Differences in sensitivity and specificity in the detection of polyps between the sets were not significant. CONCLUSION: Volume and average CT attenuation thresholds can help differentiate most ICVs from true polyps. [copy ] RSNA, 2006 JF - Radiology AU - O'Connor, Stacy D AU - Summers, Ronald M AU - Yao, Jianhua AU - Pickhardt, Perry J AU - Choi, JRichard AD - Department of Radiology, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 1C351, MSC 1182, Bethesda, MD 20892-1182 (S.D.O., R.M.S., J.Y.) Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 426 EP - 432 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 241 IS - 2 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Segmentation KW - Algorithms KW - Image processing KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+interactive+MRI-guided+cardiac+surgery%3A+Aortic+valve+replacement+using+a+direct+apical+approach&rft.au=McVeigh%2C+Elliot+R%3BGuttman%2C+Michael+A%3BLederman%2C+Robert+J%3BLi%2C+Ming%3BKocaturk%2C+Ozgur%3BHunt%2C+Timothy%3BKozlov%2C+Shawn%3BHorvath%2C+Keith+A&rft.aulast=McVeigh&rft.aufirst=Elliot&rft.date=2006-11-01&rft.volume=56&rft.issue=5&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Polyps; Computed tomography; Algorithms; Segmentation; Image processing ER - TY - JOUR T1 - Mesenchymal Stem Cell-Organized Bone Marrow Elements: An Alternative Hematopoietic Progenitor Resource AN - 19463841; 7126873 AB - Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of {szligbeta}-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value. JF - Stem Cells AU - Miura, Yasuo AU - Gao, Zhigang AU - Miura, Masako AU - Seo, Byoung-Moo AU - Sonoyama, Wataru AU - Chen, WanJun AU - Gronthos, Stan AU - Zhang, Li AU - Shi, Songtao AD - National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA. Division of Immunology/Hematology, The Sidney-Kimmel Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. Department of Physiology, The University of Maryland School of Medicine, Rockville, Maryland, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2428 EP - 2436 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Platelet-derived growth factor KW - Bone diseases KW - Bone marrow KW - Hemopoiesis KW - Graft-versus-host reaction KW - Mesenchyme KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Mesenchymal+Stem+Cell-Organized+Bone+Marrow+Elements%3A+An+Alternative+Hematopoietic+Progenitor+Resource&rft.au=Miura%2C+Yasuo%3BGao%2C+Zhigang%3BMiura%2C+Masako%3BSeo%2C+Byoung-Moo%3BSonoyama%2C+Wataru%3BChen%2C+WanJun%3BGronthos%2C+Stan%3BZhang%2C+Li%3BShi%2C+Songtao&rft.aulast=Miura&rft.aufirst=Yasuo&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=2428&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hemopoiesis; Stem cells; Bone marrow; Platelet-derived growth factor; Mesenchyme; Graft-versus-host reaction; Bone diseases ER - TY - JOUR T1 - NK Cell-Derived IFN- gamma Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis AN - 19394348; 7166875 AB - Although it is known that IFN- gamma -secreting T cells are critical for control of Mycobacterium tuberculosis infection, the contribution of IFN- gamma produced by NK cells to host resistance to the pathogen is less well understood. By using T cell-deficient RAG super(-/-) mice, we showed that M. tuberculosis stimulates NK cell-dependent IFN- gamma production in naive splenic cultures and in lungs of infected animals. More importantly, common cytokine receptor gamma -chain super(-/-)RAG super(-/-) animals deficient in NK cells, p40 super(-/-)RAG super(-/-), or anti-IFN- gamma mAb-treated RAG super(-/-) mice displayed significantly increased susceptibility to M. tuberculosis infection compared with untreated NK-sufficient RAG super(-/-) controls. Studies comparing IL-12 p40- and p35-deficient RAG super(-/-) mice indicated that IL-12 plays a more critical role in the induction of IFN- gamma -mediated antimycobacterial effector functions than IL-23 or other p40-containing IL-12 family members. The increased susceptibility of IL-12-deficient or anti-IFN- gamma mAb-treated RAG super(-/-) mice was associated not only with elevated bacterial loads, but also with the development of granulocyte-enriched foci in lungs. This tissue response correlated with increased expression of the granulocyte chemotactic chemokines KC and MIP-2 in NK as well as other leukocyte populations. Interestingly, depletion of granulocytes further increased bacterial burdens and exacerbated pulmonary pathology in these animals, revealing a compensatory function for neutrophils in the absence of IFN- gamma . The above observations indicate that NK cell-derived IFN- gamma differentially regulates T-independent resistance and granulocyte function in M. tuberculosis infection and suggest that this response could serve as an important barrier in AIDS patients or other individuals with compromised CD4 super(+) T cell function. JF - Journal of Immunology AU - Feng, Carl G AU - Kaviratne, Mallika AU - Rothfuchs, Antonio Gigliotti AU - Cheever, Allen AU - Hieny, Sara AU - Young, Howard A AU - Wynn, Thomas A AU - Sher, Alan AD - Immunobiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Biomedical Research Institute, Rockville, MD 20852. Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 7086 EP - 7093 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Acquired immune deficiency syndrome KW - Leukocytes (neutrophilic) KW - Natural killer cells KW - Spleen KW - Cell culture KW - Pathogens KW - Infection KW - Leukocytes (granulocytic) KW - Interleukin 12 KW - CD4 antigen KW - chemokine KC KW - Interleukin 23 KW - Lung KW - Cytokine receptors KW - Lymphocytes T KW - Tuberculosis KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=NK+Cell-Derived+IFN-+gamma+Differentially+Regulates+Innate+Resistance+and+Neutrophil+Response+in+T+Cell-Deficient+Hosts+Infected+with+Mycobacterium+tuberculosis&rft.au=Feng%2C+Carl+G%3BKaviratne%2C+Mallika%3BRothfuchs%2C+Antonio+Gigliotti%3BCheever%2C+Allen%3BHieny%2C+Sara%3BYoung%2C+Howard+A%3BWynn%2C+Thomas+A%3BSher%2C+Alan&rft.aulast=Feng&rft.aufirst=Carl&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=7086&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Acquired immune deficiency syndrome; Natural killer cells; Leukocytes (neutrophilic); Spleen; Cell culture; Pathogens; Infection; Interleukin 12; Leukocytes (granulocytic); CD4 antigen; Interleukin 23; chemokine KC; Lung; Lymphocytes T; Cytokine receptors; Tuberculosis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Pertussis Toxin Is Superior to TLR Ligands in Enhancing Pathogenic Autoimmunity, Targeted at a Neo-Self Antigen, by Triggering Robust Expansion of Th1 Cells and Their Cytokine Production AN - 19394320; 7166854 AB - Microbial products are assumed to play a major role in triggering pathogenic autoimmunity. Recently accumulated data have shown that these products stimulate the immune system by interacting with TLRs, expressed on APCs. To examine the capacity of various TLR ligands to trigger pathogenic autoimmunity, we used a system in which naive CD4 cells, specific against hen egg lysozyme (HEL), are injected into recipient mice expressing HEL in their eyes. Only when stimulated, the naive cells acquire pathogenic capacity and induce ocular inflammation. Seven TLR ligands were tested in this system: lipoteichoic acid/peptidoglycan, zymosan, poly (I:C), LPS, pertussis toxin (PTX), flagellin, and CpG oligodeoxynucleotide. Treatment of recipient mice with HEL alone stimulated proliferation of the transferred cells, but no disease, whereas ocular inflammation did develop in recipient mice coinjected with HEL and any one of the seven TLR ligands. Inflammation induced by PTX surpassed by its severity those induced by all other tested TLR ligands and was accompanied by a dramatic increase in number of the transferred cells that acquired features of effector Th1 lymphocytes. Ocular inflammation and number of transferred cells in recipients injected with PTX and HEL were substantially reduced by treatment with Abs against IFN- gamma or IL-12, thus indicating the role of these cytokines in the PTX effect. Overall, our observations demonstrate that various TLR ligands are capable of triggering pathogenic autoimmunity and that PTX surpasses other microbial products in this activity, by stimulating excessive proliferation and polarization toward Th1 of naive T cells. JF - Journal of Immunology AU - Fujimoto, Chiaki AU - Yu, Cheng-Rong AU - Shi, Guangpu AU - Vistica, Barbara P AU - Wawrousek, Eric F AU - Klinman, Dennis M AU - Chan, Chi-Chao AU - Egwuagu, Charles E AU - Gery, Igal AD - Laboratory of Immunology and Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6896 EP - 6903 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Lysozyme KW - Poly (I:C) KW - Data processing KW - Helper cells KW - Immune system KW - Autoimmunity KW - peptidoglycans KW - CpG islands KW - Polarization KW - Oligonucleotides KW - pertussis toxin KW - Inflammation KW - Lipoteichoic acid KW - Interleukin 12 KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - Antigen-presenting cells KW - Cell proliferation KW - Flagellin KW - X 24490:Other KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Pertussis+Toxin+Is+Superior+to+TLR+Ligands+in+Enhancing+Pathogenic+Autoimmunity%2C+Targeted+at+a+Neo-Self+Antigen%2C+by+Triggering+Robust+Expansion+of+Th1+Cells+and+Their+Cytokine+Production&rft.au=Fujimoto%2C+Chiaki%3BYu%2C+Cheng-Rong%3BShi%2C+Guangpu%3BVistica%2C+Barbara+P%3BWawrousek%2C+Eric+F%3BKlinman%2C+Dennis+M%3BChan%2C+Chi-Chao%3BEgwuagu%2C+Charles+E%3BGery%2C+Igal&rft.aulast=Fujimoto&rft.aufirst=Chiaki&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=6896&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Lysozyme; gamma -Interferon; Data processing; Poly (I:C); Immune system; Helper cells; peptidoglycans; Autoimmunity; CpG islands; Polarization; Oligonucleotides; Inflammation; pertussis toxin; Lipoteichoic acid; Interleukin 12; CD4 antigen; Lymphocytes T; Lipopolysaccharides; Cytokines; Antigen-presenting cells; Cell proliferation; Flagellin ER - TY - JOUR T1 - Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells AN - 19393808; 7147837 AB - Chronic arsenic exposure of rat liver epithelial TRL1215 cells induced malignant transformation in a concentration-dependent manner. To further define the molecular events of these arsenic-transformed cells (termed CAsE cells), gene expressions associated with arsenic carcinogenesis or influenced by methylation were examined. Real-time RT-PCR showed that at carcinogenic concentrations (500 nM, and to a less extent 250 nM of arsenite), the expressions of alpha -fetoprotein (AFP), Wilm's tumor protein-1 (WT-1), c-jun, c-myc, H-ras, c-met and hepatocyte growth factor, heme oxygenase-1, superoxide dismutase-1, glutathione-S-transferase- pi and metallothionein-1 (MT) were increased between 3 to 12-fold, while expressions of insulin-like growth factor II (IGF-II) and fibroblast growth factor receptor (FGFR1) were essentially abolished. These changes were not significant at the non-carcinogenic concentration (125 nM), except for IGF-II. The positive cell-cycle regulators cyclin D1 and PCNA were overexpressed in CAsE cells, while the negative regulators p21 and p16 were suppressed. Western-blot confirmed increases in AFP, WT-1, cyclin D1 and decreases in p16 and p21 protein in CAsE cells. The CAsE cells over-expressed MT but the demethylating agent 5-aza-deoxycytidine (5-aza-dC, 2.5 mu M, 72 h) stimulated further MT expression. 5-Aza-deoxycytidine restored the loss of expression of p21 in CAsE cells to control levels, but did not restore the expression of p16, IGF-II, or FGFR1, indicating the loss of expression of these genes is due to factors other than DNA methylation changes. Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation. JF - Toxicology and Applied Pharmacology AU - Liu, J AU - Benbrahim-Tallaa, L AU - Qian, X AU - Yu, L AU - Xie, Y AU - Boos, J AU - Qu, W AU - Waalkes, M P AD - Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F-09, Research Triangle Park, NC 27709, USA, Liu6@niehs.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 407 EP - 415 VL - 216 IS - 3 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Toxicology Abstracts KW - Transformation KW - Fibroblast growth factor receptors KW - Hepatocytes KW - H-Ras protein KW - alpha -fetoprotein KW - Gene expression KW - Oncogenes KW - cyclin-dependent kinase inhibitor p21 KW - DNA methylation KW - Polymerase chain reaction KW - Azacytidine KW - Insulin-like growth factor II KW - c-Myc protein KW - cyclin D1 KW - Arsenic KW - Fibroblast growth factor receptor 1 KW - Arsenite KW - Heme oxygenase (decyclizing) KW - Tumors KW - Proliferating cell nuclear antigen KW - c-Jun protein KW - Superoxide KW - Transcription factors KW - Carcinogenesis KW - Cyclin-dependent kinase inhibitor p21 KW - Hepatocyte growth factor KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Further+studies+on+aberrant+gene+expression+associated+with+arsenic-induced+malignant+transformation+in+rat+liver+TRL1215+cells&rft.au=Liu%2C+J%3BBenbrahim-Tallaa%2C+L%3BQian%2C+X%3BYu%2C+L%3BXie%2C+Y%3BBoos%2C+J%3BQu%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-11-01&rft.volume=216&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Fibroblast growth factor receptors; Hepatocytes; H-Ras protein; alpha -fetoprotein; Gene expression; Oncogenes; cyclin-dependent kinase inhibitor p21; DNA methylation; Azacytidine; Polymerase chain reaction; Insulin-like growth factor II; c-Myc protein; cyclin D1; Arsenic; Fibroblast growth factor receptor 1; Arsenite; Heme oxygenase (decyclizing); Tumors; c-Jun protein; Proliferating cell nuclear antigen; Transcription factors; Superoxide; Carcinogenesis; Cyclin-dependent kinase inhibitor p21; Hepatocyte growth factor DO - http://dx.doi.org/10.1016/j.taap.2006.06.006 ER - TY - JOUR T1 - HIV gp120-induced Interaction between CD4 and CCR5 Requires Cholesterol-rich Microenvironments Revealed by Live Cell Fluorescence Resonance Energy Transfer Imaging AN - 19393326; 7166531 AB - Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the plasma membrane initiates the viral entry process. Although plasma membrane cholesterol plays an important role in HIV entry, its modulating effect on the viral entry process is unclear. Using fluorescence resonance energy transfer imaging, we have provided evidence here that CD4 and CCR5 localize in different microenvironments on the surface of resting cells. Binding of the third variable region V3-containing gp120 core to CD4 and CCR5 induced association between these receptors, which could be directly monitored by fluorescence resonance energy transfer on the plasma membrane of live cells. Depletion of cholesterol from the plasma membrane abolished the gp120 core-induced associations between CD4 and CCR5, and reloading cholesterol restored the associations in live cells. Our studies suggest that, during the first step of the HIV entry process, gp120 binding alters the microenvironments of unbound CD4 and CCR5, with plasma membrane cholesterol required for the formation of the HIV entry complex. JF - Journal of Biological Chemistry AU - Yi, Ling AU - Fang, Jun AU - Isik, Nilgun AU - Chim, Jimmy AU - Jin, Tian AD - Laboratory of Immunogenetics, Twinbrook II Facility, NIAID, National Institutes of Health, Rockville, Maryland 20852 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 35446 EP - 35453 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 46 SN - 0021-9258, 0021-9258 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - fluorescence resonance energy transfer KW - CCR5 protein KW - Glycoprotein gp120 KW - CD4 antigen KW - Envelopes KW - Cores KW - Plasma membranes KW - Cholesterol KW - imaging KW - Human immunodeficiency virus KW - Microenvironments KW - Variable region KW - V 22360:AIDS and HIV KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=HIV+gp120-induced+Interaction+between+CD4+and+CCR5+Requires+Cholesterol-rich+Microenvironments+Revealed+by+Live+Cell+Fluorescence+Resonance+Energy+Transfer+Imaging&rft.au=Yi%2C+Ling%3BFang%2C+Jun%3BIsik%2C+Nilgun%3BChim%2C+Jimmy%3BJin%2C+Tian&rft.aulast=Yi&rft.aufirst=Ling&rft.date=2006-11-01&rft.volume=281&rft.issue=46&rft.spage=35446&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; CCR5 protein; CD4 antigen; Plasma membranes; Glycoprotein gp120; Cholesterol; fluorescence resonance energy transfer; Microenvironments; imaging; Variable region; Cores; Envelopes ER - TY - JOUR T1 - Functional Analysis of CbpA, a DnaJ Homolog and Nucleoid-associated DNA-binding Protein AN - 19391538; 7166417 AB - DnaK/Hsp70 proteins are universally conserved ATP-dependent molecular chaperones that help proteins adopt and maintain their native conformations. DnaJ/Hsp40 and GrpE are co-chaperones that assist DnaK. CbpA is an Escherichia coli DnaJ homolog. It acts as a multicopy suppressor for dnaJ mutations and functions in vitro in combination with DnaK and GrpE in protein remodeling reactions. CbpA binds nonspecifically to DNA with preference for curved DNA and is a nucleoid-associated protein. The DNA binding and co-chaperone activities of CbpA are modulated by CbpM, a small protein that binds specifically to CbpA. To identify the regions of CbpA involved in the interaction of CbpA with CbpM and those involved in DNA binding, we constructed and characterized deletion and substitution mutants of CbpA. We discovered that CbpA interacted with CbpM through its N-terminal J-domain. We found that the region C-terminal to the J-domain was required for DNA binding. Moreover, we found that the CbpM interaction, DNA binding, and co-chaperone activities were separable; some mutants were proficient in some functions and defective in others. JF - Journal of Biological Chemistry AU - Bird, Jeremy G AU - Sharma, Suveena AU - Roshwalb, Sara C AU - Hoskins, Joel R AU - Wickner, Sue AD - Laboratory of Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 34349 EP - 34356 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 45 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - HSP40 protein KW - Deletion KW - Hsp70 protein KW - DNA-binding protein KW - Escherichia coli KW - Chaperones KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Functional+Analysis+of+CbpA%2C+a+DnaJ+Homolog+and+Nucleoid-associated+DNA-binding+Protein&rft.au=Bird%2C+Jeremy+G%3BSharma%2C+Suveena%3BRoshwalb%2C+Sara+C%3BHoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Bird&rft.aufirst=Jeremy&rft.date=2006-11-01&rft.volume=281&rft.issue=45&rft.spage=34349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - HSP40 protein; Deletion; Hsp70 protein; DNA-binding protein; Chaperones; Mutation; Escherichia coli ER - TY - JOUR T1 - Litter production, decomposition and nutrient return of uplifted coral reef tropical forest AN - 19381656; 7148320 AB - Four habitat types in a 10-ha permanent plot of an uplifted coral reef forest in southern Taiwan were chosen and subjected to systematic litterfall related processes. Ebenaceae and Euphorbiaceae were the dominant families. The common species in the four habitats were Diospyros maritime, Ficus benjamina and Melanolepis multiglandulosa. Habitat I on the flat terrace was dominated by Bischofia javanica and Palaquium formosanum; habitat II on the ridge of exposed coral reef was dominated by Aglaia formosana and Pouteria obovata; habitat III on the sedimentary basin was dominated by Macaranga tanariu; habitat IV at the bottom of valley was dominated by Pisonia umbellifera. Litter productions, decomposition processes and nutrient returns were monitored over a 12-month period in the four habitats. Bulk litter was gathered from traps for monthly accession of litterfall. Mixed-species litter bags containing equal portions of the individual species were used to measure the decomposition constants of the leaf litter. Fresh and decomposing litters were analyzed for C, N, P, Ca, Mg, K and Na. Experimental results indicated that mean monthly litterfall in all the habitats displayed a marked seasonal pattern, with spring troughs and summer, autumn and winter peaks associated with the typhoon and monsoon seasons. The annual litterfall ranged from 6.98 to 9.13Mgha super(-) super(1)year super(-) super(1), is within but in the higher range for tropical forests. The litterfall production in habitats I and IV was significantly (pMg=N>Na>K>P>mass>C. Carbon was returned to the forest floor in the highest amount, and the next element was Ca which ranged from 196 to 324kgha super(-) super(1)year super(-) super(1). Surprisingly, the annual returns of Ca significantly exceeded those of N, and differed significantly from those of other tropical forests. JF - Forest Ecology and Management AU - Liao, J H AU - Wang, H H AU - Tsai, C C AU - Hseu, Z Y AD - National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu, Pingtung 91201, Taiwan, zyhseu@mail.npust.edu.tw Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 174 EP - 185 PB - Elsevier B.V. VL - 235 IS - 1-3 SN - 0378-1127, 0378-1127 KW - Ecology Abstracts; Sustainability Science Abstracts KW - Diospyros KW - Ficus benjamina KW - Litter KW - Macaranga tanarius KW - Bischofia javanica KW - Forests KW - Nutrients KW - Habitat KW - Decomposition KW - Leaf litter KW - Pisonia KW - Ebenaceae KW - Coral reefs KW - Euphorbiaceae KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19381656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forest+Ecology+and+Management&rft.atitle=Litter+production%2C+decomposition+and+nutrient+return+of+uplifted+coral+reef+tropical+forest&rft.au=Liao%2C+J+H%3BWang%2C+H+H%3BTsai%2C+C+C%3BHseu%2C+Z+Y&rft.aulast=Liao&rft.aufirst=J&rft.date=2006-11-01&rft.volume=235&rft.issue=1-3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Forest+Ecology+and+Management&rft.issn=03781127&rft_id=info:doi/10.1016%2Fj.foreco.2006.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Leaf litter; Litter; Coral reefs; Forests; Nutrients; Habitat; Decomposition; Ficus benjamina; Diospyros; Pisonia; Macaranga tanarius; Ebenaceae; Bischofia javanica; Euphorbiaceae DO - http://dx.doi.org/10.1016/j.foreco.2006.08.010 ER - TY - JOUR T1 - Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations AN - 19376565; 7121319 AB - Epidemiological studies suggest that UV exposure from sunlight is the major etiology for skin cancers, both melanocytic and non-melanocytic. However, the radiation-related risk for skin cancer among atomic bomb survivors of Hiroshima and Nagasaki is primarily derived from the excess risk of basal cell carcinoma (BCC), with no demonstrable excess in squamous cell carcinoma or melanoma. The BCCs in this cohort are therefore unusual in being potentially attributable to two types of radiation-UV and ionizing (IR). BCCs have been associated with PTCH and/or p53 tumor suppressor gene alterations. To investigate the roles of these genes in relation to IR and UV exposures, we analyzed both genes in BCC samples from atomic bomb survivors. We examined 47 tumors, of which 70% had non-silent base-substitution p53 mutations independent of IR or UV exposure. However, the distribution of mutation type depends on UV and/or IR exposure. For example, C-to-T transitions at CpG sites adjacent to pyrimidine-pyrimidine (PyPy) sequences were more prevalent in tumors from UV-exposed than UV-shielded body areas and CpG-mutations at non-PyPy sequences were more prevalent in tumors from UV-shielded body areas with high-IR ( greater than or equal to 1 Gy) than low-IR (<0.2 Gy) exposure. And notably, although p53 deletion-frequencies demonstrated no IR-dose associations, deletions at the PTCH locus were more frequent (79% versus 44%) in tumors with high-IR than low-IR exposure. Moreover, 60% of high-IR tumors harbored both p53 and PTCH abnormalities compared with 23% of low-IR tumors. Therefore, alteration of both genes is likely to play a role in radiation-induced basal cell carcinogenesis. JF - Carcinogenesis AU - Mizuno, Terumi AU - Tokuoka, Shoji AU - Kishikawa, Masao AU - Nakashima, Eiji AU - Mabuchi, Kiyohiko AU - Iwamoto, Keisuke S AD - Department of Radiobiology/Molecular Epidemiology Hiroshima 732-0815, Japan. Department of Epidemiology Hiroshima 732-0815, Japan. Department of Statistics at the Radiation Effects Research Foundation Hiroshima 732-0815, Japan. Nagasaki Institute for Diagnostic Pathology Isahaya, Japan. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, 20892-1611, USA. Roy E. Coats Research Laboratories, Department of Radiation Oncology, University of California Los Angeles, CA, 90095-1714, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2286 EP - 2294 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 11 SN - 0143-3334, 0143-3334 KW - Genetics Abstracts; Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Ptch protein KW - Etiology KW - Atomic bombs KW - Skin cancer KW - squamous cell carcinoma KW - CpG islands KW - Tumors KW - p53 protein KW - Melanoma KW - Gene deletion KW - Basal cells KW - Carcinogenesis KW - Sunlight KW - Mutation KW - X 24390:Radioactive Materials KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19376565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Molecular+basis+of+basal+cell+carcinogenesis+in+the+atomic-bomb+survivor+population%3A+p53+and+PTCH+gene+alterations&rft.au=Mizuno%2C+Terumi%3BTokuoka%2C+Shoji%3BKishikawa%2C+Masao%3BNakashima%2C+Eiji%3BMabuchi%2C+Kiyohiko%3BIwamoto%2C+Keisuke+S&rft.aulast=Mizuno&rft.aufirst=Terumi&rft.date=2006-11-01&rft.volume=27&rft.issue=11&rft.spage=2286&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ptch protein; Tumor suppressor genes; Etiology; Atomic bombs; Skin cancer; squamous cell carcinoma; Tumors; CpG islands; Melanoma; p53 protein; Basal cells; Gene deletion; Carcinogenesis; Sunlight; Mutation ER - TY - JOUR T1 - Possible Therapeutic Vaccine Strategy against Human Immunodeficiency Virus Escape from Reverse Transcriptase Inhibitors Studied in HLA-A2 Transgenic Mice AN - 19367468; 7125109 AB - Mutation of human immunodeficiency virus (HIV) leading to escape from anti-HIV drugs is the greatest challenge to the treatment of HIV infection. High-grade resistance to the nucleoside reverse transcriptase (RT) inhibitor lamivudine (also known as 3TC) is associated with a substitution of valine for methionine at position 184 of RT. This amino acid residue is contained within the HLA-A2-restricted epitope VIYQYMDDL (RT-WT). Here, we sought to determine whether a peptide vaccine could be developed using an epitope enhancement strategy that could induce a cytotoxic T-lymphocyte (CTL) response specific for an epitope containing the drug resistance mutation M184V to exert an opposing selective pressure. RT-WT-specific CTLs developed from HLA-A2 transgenic mice did not recognize the M184V mutation of RT-WT (RT-M184V). However, RT-M184V exhibited higher binding affinity for HLA-A2 than RT-WT. Also, both anchor-enhanced RT-WT (RT-2L9V) and RT-2L9V-M184V-specific CTLs recognized RT-M184V and displayed cross-reactivity to RT-WT. Nevertheless, the CTL repertoire elicited by the epitope-enhanced RT-2L9V-M184V appeared more selective for the RT inhibitor-induced M184V mutation. Peptide vaccines based on such strategies may be worth testing for their ability to exert selective pressure against drug-resistant strains and thus delay or prevent the development of HIV with the M184V resistance mutation. JF - Journal of Virology AU - Okazaki, Takahiro AU - Terabe, Masaki AU - Catanzaro, Andrew T AU - Pendleton, CDavid AU - Yarchoan, Robert AU - Berzofsky, Jay A AD - Vaccine Branch. HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1578 Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10645 EP - 10651 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 21 SN - 0022-538X, 0022-538X KW - HIV KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Histocompatibility antigen HLA KW - Amino acid substitution KW - Cross-reactivity KW - Lamivudine KW - Lymphocytes T KW - RNA-directed DNA polymerase KW - Amino acids KW - valine KW - Vaccines KW - Mutation KW - Drug resistance KW - Infection KW - Methionine KW - Epitopes KW - Transgenic mice KW - Cytotoxicity KW - Human immunodeficiency virus KW - nucleosides KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Possible+Therapeutic+Vaccine+Strategy+against+Human+Immunodeficiency+Virus+Escape+from+Reverse+Transcriptase+Inhibitors+Studied+in+HLA-A2+Transgenic+Mice&rft.au=Okazaki%2C+Takahiro%3BTerabe%2C+Masaki%3BCatanzaro%2C+Andrew+T%3BPendleton%2C+CDavid%3BYarchoan%2C+Robert%3BBerzofsky%2C+Jay+A&rft.aulast=Okazaki&rft.aufirst=Takahiro&rft.date=2006-11-01&rft.volume=80&rft.issue=21&rft.spage=10645&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Cytotoxicity; Lymphocytes T; Mutation; Histocompatibility antigen HLA; Vaccines; Epitopes; Transgenic mice; Drug resistance; RNA-directed DNA polymerase; Cross-reactivity; Amino acids; Amino acid substitution; Lamivudine; nucleosides; valine; Infection; Methionine ER - TY - JOUR T1 - Nonsegmented Negative-Strand Viruses as Vaccine Vectors AN - 19364287; 7125076 JF - Journal of Virology AU - Bukreyev, Alexander AU - Skiadopoulos, Mario H AU - Murphy, Brian R AU - Collins, Peter L AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10293 EP - 10306 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 21 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Vaccines KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19364287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Nonsegmented+Negative-Strand+Viruses+as+Vaccine+Vectors&rft.au=Bukreyev%2C+Alexander%3BSkiadopoulos%2C+Mario+H%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2006-11-01&rft.volume=80&rft.issue=21&rft.spage=10293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccines ER - TY - JOUR T1 - Patterns in food intake correlate with body mass index AN - 19359634; 7119719 AB - Quantifying eating behavior may give clues to both the physiological and behavioral mechanisms behind weight regulation. We analyzed year-long dietary records of 29 stable-weight subjects. The records showed wide daily variations of food intake. We computed the temporal autocorrelation and skewness of food intake mass, energy, carbohydrate, fat, and protein. We also computed the cross-correlation coefficient between intake mass and intake energy. The mass of the food intake exhibited long-term trends that were positively skewed, with wide variability among individuals. The average duration of the trends (P = 0.003) and the skewness (P = 0.006) of the food intake mass were significantly correlated with mean body mass index (BMI). We also found that the lower the correlation coefficient between the energy content and the mass of food intake, the higher the BMI. Our results imply that humans in neutral energy balance eating ad libitum exhibit a long-term positive bias in the food intake that operates partially through the mass of food eaten to defend against eating too little more vigorously than eating too much. JF - American Journal of Physiology: Endocrinology and Metabolism AU - Periwal, Vipul AU - Chow, Carson C AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - E929 EP - E936 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 291 IS - 5 SN - 0193-1849, 0193-1849 KW - Physical Education Index KW - Behavior KW - Body mass KW - Analysis KW - Physiology KW - Diet (weight control) KW - Discrimination KW - Proteins KW - Carbohydrates KW - Trends KW - Balance KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19359634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Endocrinology+and+Metabolism&rft.atitle=Patterns+in+food+intake+correlate+with+body+mass+index&rft.au=Periwal%2C+Vipul%3BChow%2C+Carson+C&rft.aulast=Periwal&rft.aufirst=Vipul&rft.date=2006-11-01&rft.volume=291&rft.issue=5&rft.spage=E929&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Endocrinology+and+Metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Behavior; Analysis; Body mass; Physiology; Diet (weight control); Proteins; Discrimination; Carbohydrates; Trends; Balance ER - TY - JOUR T1 - Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process AN - 19359503; 7127069 AB - Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and regulatory agencies worldwide. A workshop was held at the Research Triangle Park campus of the Environmental Protection Agency to discuss the current state-of-the-science of "immunotoxicogenomics" and to explore the potential role of genomics techniques for immunotoxicity testing. The genesis of the workshop was the current lack of widely accepted triggering criteria for Tier 1 immunotoxicity testing in the context of routine toxicity testing data, the realization that traditional screening methods would require an inordinate number of animals and are inadequate to handle the number of chemicals that may need to be screened (e.g., high production volume compounds) and the absence of an organized effort to address the state-of-the-science of toxicogenomics in the identification of immunotoxic compounds. The major focus of the meeting was on the theoretical and practical utility of genomics techniques to (1) replace or supplement current immunotoxicity screening procedures, (2) provide insight into potential modes or mechanisms of action, and (3) provide data suitable for immunotoxicity hazard identification or risk assessment. The latter goal is of considerable interest to a variety of stakeholders as a means to reduce animal use and to decrease the cost of conducting and interpreting standard toxicity tests. A number of data gaps were identified that included a lack of dose response and kinetic data for known immunotoxic compounds and a general lack of data correlating genomic alterations to functional changes observed in vivo. Participants concluded that a genomics approach to screen chemicals for immunotoxic potential or to generate data useful to risk assessors holds promise but that routine use of these methods is years in the future. However, recent progress in molecular immunology has made mode and mechanism of action studies much more practical. Furthermore, a variety of published immunotoxicity studies suggest that microarray analysis is already a practical means to explore pathway-level changes that lead to altered immune function. To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development. JF - Toxicological Sciences AU - Luebke, Robert W AU - Holsapple, Michael P AU - Ladics, Gregory S AU - Luster, Michael I AU - Selgrade, MaryJane AU - Smialowicz, Ralph J AU - Woolhiser, Michael R AU - Germolec, Dori R AD - Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. International Life Sciences Institute, Health and Environmental Sciences Institute, Washington, District of Columbia 20005. DuPont Crop Genetics, Wilmington, Delaware 19880. Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505. Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 22 EP - 27 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 94 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Data processing KW - Toxicants KW - Conferences KW - Toxicity KW - Gene expression KW - Immunotoxicity KW - Quality control KW - Kinetics KW - Parks KW - Immune response KW - genomics KW - Toxicity testing KW - G 07720:Immunogenetics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19359503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Immunotoxicogenomics%3A+The+Potential+of+Genomics+Technology+in+the+Immunotoxicity+Risk+Assessment+Process&rft.au=Luebke%2C+Robert+W%3BHolsapple%2C+Michael+P%3BLadics%2C+Gregory+S%3BLuster%2C+Michael+I%3BSelgrade%2C+MaryJane%3BSmialowicz%2C+Ralph+J%3BWoolhiser%2C+Michael+R%3BGermolec%2C+Dori+R&rft.aulast=Luebke&rft.aufirst=Robert&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1106-1365 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Conferences; Toxicants; Toxicity; Gene expression; Immunotoxicity; Kinetics; Quality control; Parks; genomics; Immune response; Toxicity testing ER - TY - JOUR T1 - Risk factors for Mycobacterium tuberculosis in US chronic dialysis patients AN - 19289801; 7125751 AB - BACKGROUND: End-stage renal disease is known to disrupt the cell-mediated immune response that is responsible for the killing of intracellular organisms such as Mycobacterium tuberculosis. Risk factors that contribute to the development of tuberculosis (TB) disease in the US dialysis population have not been studied on a large scale. METHODS: A retrospective cohort study of TB disease in 272 024 patients in the US Renal Data System initiated on dialysis therapy between 1 April 1995 and 31 December 1999 with Medicare or Medicaid as primary payer were analysed. A total of 21 risk factors were analysed. RESULTS: Among the US population studied, there is a 1.2 and 1.6% cumulative incidence of TB in patients undergoing either peritoneal or haemodialysis, respectively. Ten risk factors for TB that proved to be statistically significant included advanced age (P < 0.001), unemployment (P < 0.001), Medicaid insurance (P < 0.001), reduced body mass index (P < 0.001), decreased serum albumin (P < 0.001), haemodialysis (P = 0.019), both Asian (P = 0.010) and Native American (P = 0.020) race, ischaemic heart disease (P = 0.032), smoking (P = 0.010), illicit drug use (P = 0.018) and anaemia (P = 0.028). TB was independently associated with increased mortality, adjusted hazard ratio (AHR) 1.42 (95% CI 1.18-1.70, P < 0.001). CONCLUSIONS: The prevalence of TB disease in the US dialysis population is low compared with worldwide rates; however, the disease is associated with increased mortality. Of the 10 significant risk factors identified, five are potentially modifiable. JF - Nephrology, Dialysis and Transplantation AU - Klote, Mary M AU - Agodoa, Lawrence Y AU - Abbott, Kevin C AD - Allergy Immunology Department, Walter Reed Army Medical Center, Washington, DC, NIDDK, NIH, Bethesda, MD, Nephrology Service, Walter Reed Army Medical Center, Washington, DC and Uniformed Services University of the Health Sciences, Bethesda, MD, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3287 EP - 3292 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 11 SN - 0931-0509, 0931-0509 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Age KW - Data processing KW - Peritoneum KW - Statistical analysis KW - Anemia KW - Population studies KW - Hemodialysis KW - Smoking KW - Immune response (cell-mediated) KW - Risk factors KW - Albumin KW - Kidney KW - Tuberculosis KW - Body mass index KW - Drugs KW - Races KW - Mycobacterium tuberculosis KW - Heart diseases KW - End-stage renal disease KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19289801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephrology%2C+Dialysis+and+Transplantation&rft.atitle=Risk+factors+for+Mycobacterium+tuberculosis+in+US+chronic+dialysis+patients&rft.au=Klote%2C+Mary+M%3BAgodoa%2C+Lawrence+Y%3BAbbott%2C+Kevin+C&rft.aulast=Klote&rft.aufirst=Mary&rft.date=2006-11-01&rft.volume=21&rft.issue=11&rft.spage=3287&rft.isbn=&rft.btitle=&rft.title=Nephrology%2C+Dialysis+and+Transplantation&rft.issn=09310509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Data processing; Peritoneum; Anemia; Statistical analysis; Population studies; Hemodialysis; Smoking; Immune response (cell-mediated); Risk factors; Albumin; Kidney; Tuberculosis; Body mass index; Drugs; Races; End-stage renal disease; Heart diseases; Mycobacterium tuberculosis ER - TY - JOUR T1 - Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic AN - 1500756559; 19046453 AB - There are important gaps in our current understanding of the influenza virus behavior. In particular, it remains unclear why some inter-pandemic seasons are associated with unusually high mortality impact, sometimes comparable to that of pandemics. Here we compare the epidemiological patterns of the unusually deadly 1951 influenza epidemic (A/H1N1) in England and Wales and Canada with those of surrounding epidemic and pandemic seasons, in terms of overall mortality impact and transmissibility. Based on the statistical and mathematical analysis of vital statistics and morbidity epidemic curves in these two countries, we show that the 1951 epidemic was associated with both higher mortality impact and higher transmissibility than the 1957 and 1968 pandemics. Surprisingly in Liverpool, considered the 'epicenter' of the severe 1951 epidemic, the mortality impact and transmissibility even surpassed the 1918 pandemic. JF - Vaccine AU - Viboud, Cecile AU - Tam, Theresa AU - Fleming, Douglas AU - Handel, Andreas AU - Miller, Mark A AU - Simonsen, Lone AD - Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6701 EP - 6707 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 24 IS - 44 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Mortality KW - Epidemics KW - Statistics KW - British Isles, England KW - Vital statistics KW - Statistical analysis KW - British Isles, Wales KW - Morbidity KW - Influenza KW - pandemics KW - Influenza virus KW - British Isles, England, Merseyside, Liverpool KW - Vaccines KW - V 22490:Miscellaneous KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500756559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Transmissibility+and+mortality+impact+of+epidemic+and+pandemic+influenza%2C+with+emphasis+on+the+unusually+deadly+1951+epidemic&rft.au=Viboud%2C+Cecile%3BTam%2C+Theresa%3BFleming%2C+Douglas%3BHandel%2C+Andreas%3BMiller%2C+Mark+A%3BSimonsen%2C+Lone&rft.aulast=Viboud&rft.aufirst=Cecile&rft.date=2006-11-01&rft.volume=24&rft.issue=44&rft.spage=6701&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Influenza; Mortality; pandemics; Statistics; Epidemics; Statistical analysis; Morbidity; Vital statistics; Vaccines; Influenza virus; British Isles, England; British Isles, England, Merseyside, Liverpool; British Isles, Wales DO - http://dx.doi.org/10.1016/j.vaccine.2006.05.067 ER - TY - JOUR T1 - The role of peripheral and central sodium channels in mediating brain temperature fluctuations induced by intravenous cocaine. AN - 68983532; 16956595 AB - While cocaine's interaction with the dopamine (DA) transporter and subsequent increase in DA transmission are usually considered key factors responsible for its locomotor stimulatory and reinforcing properties, many centrally mediated physiological and psychoemotional effects of cocaine are resistant to DA receptor blockade, suggesting the importance of other non-DA mechanisms. To explore the role of cocaine's interaction with Na+ channels, rats were used to compare locomotor stimulatory and temperature (NAcc, temporal muscle and skin) effects of repeated iv injections of cocaine (1 mg/kg) with those induced by procaine (PRO 5 mg/kg), a short-acting local anesthetic with negligible effect on the DA transporter, and cocaine methiodide (COC-MET 1.31 mg/kg), a quaternary cocaine derivative that is unable to cross the blood-brain barrier. While PRO, unlike cocaine, did not induce locomotor activation, it mimicked cocaine in its ability to increase brain temperature following the initial injection and to induce biphasic, down-up fluctuations following repeated injections. This similarity suggests that both these effects of cocaine may be driven by its action on Na+ channels, a common action of both drugs. While COC-MET also did not affect locomotor activity, it shared with cocaine and PRO their ability to increase brain temperature but failed to induce temperature decreases after repeated injections. These findings point toward activation of peripheral Na+ channels as the primary mechanism of rapid excitatory effects of cocaine and inhibition of centrally located Na+ channels as the primary mechanism for transient inhibitory effects of cocaine. DA receptor blockade (SCH23390+eticlopride) fully eliminated locomotor stimulatory and temperature-increasing effects of cocaine, but its temperature-decreasing effects remained intact. Surprisingly, DA receptor blockade also altered the temperature fluctuations caused by PRO and COC-MET, suggesting that some of the central effects triggered via Na+ channels are in fact DA-dependent. Finally, repeated administration of PRO to animals that had previous cocaine experience led to conditioned locomotion and potentiated temperature-increasing effects of this drug. It appears, therefore, that, in addition to the central effects of cocaine mediated via interaction with the DA transporter and potentiation of DA uptake, interaction with peripheral and central Na+ channels is important for the initial physiological and, perhaps, affective effects of cocaine, likely contributing to the unique abuse potential of this drug. JF - Brain research AU - Kiyatkin, Eugene A AU - Brown, P Leon AD - Cellular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA. ekiyatki@intra.nida.nih.gov Y1 - 2006/10/30/ PY - 2006 DA - 2006 Oct 30 SP - 38 EP - 53 VL - 1117 IS - 1 SN - 0006-8993, 0006-8993 KW - Anesthetics, Local KW - 0 KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - Receptors, Dopamine KW - Sodium Channels KW - Procaine KW - 4Z8Y51M438 KW - cocaine methiodide KW - 5937-29-1 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Animals KW - Rats, Long-Evans KW - Peripheral Nervous System -- metabolism KW - Anesthetics, Local -- pharmacology KW - Injections, Intravenous KW - Nucleus Accumbens -- drug effects KW - Dopamine Antagonists -- pharmacology KW - Muscle, Skeletal -- innervation KW - Procaine -- pharmacology KW - Blood-Brain Barrier -- physiology KW - Peripheral Nervous System -- drug effects KW - Motor Activity -- physiology KW - Nucleus Accumbens -- physiopathology KW - Muscle, Skeletal -- drug effects KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Skin -- drug effects KW - Skin -- innervation KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- drug effects KW - Male KW - Receptors, Dopamine -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacology KW - Body Temperature -- drug effects KW - Brain -- drug effects KW - Brain Chemistry -- drug effects KW - Sodium Channels -- metabolism KW - Brain -- metabolism KW - Brain -- physiopathology KW - Cocaine -- analogs & derivatives KW - Cocaine-Related Disorders -- physiopathology KW - Body Temperature -- physiology KW - Cocaine -- pharmacology KW - Cocaine-Related Disorders -- metabolism KW - Sodium Channels -- drug effects KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68983532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+role+of+peripheral+and+central+sodium+channels+in+mediating+brain+temperature+fluctuations+induced+by+intravenous+cocaine.&rft.au=Kiyatkin%2C+Eugene+A%3BBrown%2C+P+Leon&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2006-10-30&rft.volume=1117&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 1998 Feb;28(2):111-6 [9450511] Pharmacol Biochem Behav. 1998 Feb;59(2):305-12 [9476974] J Neurosci. 1998 Mar 15;18(6):1979-86 [9482784] J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):148-59 [9608403] Prog Biophys Mol Biol. 1973;26:147-87 [4145345] Biochem Pharmacol. 1975 Apr 15;24(8):847-52 [1125084] Am J Physiol. 1976 Feb;230(2):449-55 [816208] Psychopharmacology (Berl). 1978 Apr 14;57(1):13-20 [96463] Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):67-75 [684280] Oral Surg Oral Med Oral Pathol. 1979 Oct;48(4):292-7 [291855] Brain Res. 1983 Jan 10;258(2):217-28 [6824912] Pharmacol Biochem Behav. 1983 May;18(5):711-6 [6856646] Br J Anaesth. 1985 Oct;57(10):1006-11 [4041306] Brain Res. 1985 Dec 30;361(1-2):339-50 [4084803] J Biol Chem. 1986 Jun 5;261(16):7300-5 [2423518] Psychopharmacology (Berl). 1986;90(1):142-3 [2876452] Synapse. 2001 Jan;39(1):32-41 [11071707] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6859-64 [11381119] Synapse. 2001 Sep 15;41(4):301-10 [11494401] Psychopharmacology (Berl). 2001 Sep;157(3):260-8 [11605081] Psychopharmacology (Berl). 2002 Jan;159(2):154-60 [11862343] Ann Intern Med. 2002 Jun 4;136(11):785-91 [12044126] J Neurophysiol. 2002 Jul;88(1):300-5 [12091555] Eur J Neurosci. 2002 Jul;16(1):164-8 [12153543] J Physiol. 2002 Dec 1;545(Pt 2):697-704 [12456844] Neuroscience. 2003;116(2):525-38 [12559108] Pharmacology. 2003 May;68(1):49-56 [12660479] J Neurosci. 2003 May 15;23(10):3959-62 [12764079] Brain Res. 2004 Apr 16;1005(1-2):101-16 [15044070] Am J Physiol. 1966 Sep;211(3):755-69 [5927906] Exp Neurol. 1967 Mar;17(3):293-312 [6019262] Am J Physiol. 1968 Aug;215(2):389-403 [4969787] Physiol Rev. 1991 Jan;71(1):155-234 [1986388] Eur J Pharmacol. 1991 Jun 6;198(2-3):203-5 [1864307] J Pharmacol Exp Ther. 1992 Nov;263(2):734-41 [1432699] J Pharmacol Exp Ther. 1992 Nov;263(2):757-61 [1359115] Brain Res. 1993 Oct 29;626(1-2):117-26 [8281422] Neurosci Lett. 1993 Dec 24;164(1-2):175-8 [8152597] J Physiol. 1994 Jan 15;474(2):233-43 [8006810] Eur J Pharmacol. 1994 Nov 3;264(3):391-8 [7698180] Life Sci. 1987 Mar 16;40(11):1099-111 [3821374] Pharmacol Biochem Behav. 1987 Feb;26(2):453-61 [3033700] Science. 1987 Sep 4;237(4819):1219-23 [2820058] Psychol Rev. 1987 Oct;94(4):469-92 [3317472] Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):345-64 [3423267] J Neurosci. 1988 Jan;8(1):100-12 [3339402] Int J Neurosci. 1988 Sep;42(1-2):21-43 [3209370] Psychiatry Res. 1989 Feb;27(2):117-25 [2652168] Neuropharmacology. 1989 Dec;28(12):1383-8 [2533329] NIDA Res Monogr. 1989;95:146-51 [2561820] J Pharmacol Exp Ther. 1990 Oct;255(1):154-60 [2213551] Stroke. 1990 Dec;21(12):1710-4 [2175959] Eur J Pharmacol. 1998 Dec 18;363(2-3):147-52 [9881582] J Cardiovasc Pharmacol. 1999 Jan;33(1):36-42 [9890394] Nat Neurosci. 1998 May;1(1):36-41 [10195106] Nat Neurosci. 1998 Jun;1(2):132-7 [10195128] J Neurosci. 1999 May 1;19(9):3594-609 [10212318] J Neurochem. 1999 Sep;73(3):1043-50 [10461893] Eur J Neurosci. 2004 Nov;20(10):2838-42 [15548229] Physiol Behav. 2005 Mar 31;84(4):563-70 [15811391] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10023-8 [16006505] Eur J Neurosci. 2005 Aug;22(4):930-8 [16115216] Arch Int Pharmacodyn Ther. 1971 Jan;189(1):198-208 [5130150] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] J Cereb Blood Flow Metab. 2006 Jan;26(1):68-78 [15959461] Mol Cells. 2005 Dec 31;20(3):315-24 [16404144] J Neurosci. 2006 Mar 22;26(12):3206-9 [16554471] Synapse. 1996 Dec;24(4):399-402 [10638828] Eur J Neurosci. 2000 May;12(5):1789-800 [10792456] Neuroscience. 2000;98(4):729-41 [10891616] Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H1-6 [10899035] Eur J Neurosci. 2000 Aug;12(8):2985-92 [10971639] J Pharmacol Exp Ther. 1995 Apr;273(1):128-37 [7714758] Neuroscience. 1995 Feb;64(3):599-617 [7715774] Brain Topogr. 1995 Spring;7(3):209-16 [7599020] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] Neurosci Lett. 1995 Aug 25;196(3):161-4 [7501273] Neurosci Lett. 1996 Jun 21;211(2):73-6 [8830847] Neuron. 1997 Sep;19(3):591-611 [9331351] Psychopharmacology (Berl). 1997 Sep;133(1):7-16 [9335075] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Monte Carlo Geant4 Code for Internal Dose Assessment in Nuclear Medicine T2 - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AN - 40498875; 4502935 JF - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AU - Strigari, L AU - Benassi, M AU - DAndrea, M AU - Menghi, E AU - Pressello, M C AU - dAngelo, A Y1 - 2006/10/29/ PY - 2006 DA - 2006 Oct 29 KW - Statistical analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40498875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Nuclear+Science+Symposium%2C+Medical+Imaging+Conference+and+15th+International+Room+Temperature+Semiconductor+Detector+Workshop&rft.atitle=Monte+Carlo+Geant4+Code+for+Internal+Dose+Assessment+in+Nuclear+Medicine&rft.au=Strigari%2C+L%3BBenassi%2C+M%3BDAndrea%2C+M%3BMenghi%2C+E%3BPressello%2C+M+C%3BdAngelo%2C+A&rft.aulast=Strigari&rft.aufirst=L&rft.date=2006-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Nuclear+Science+Symposium%2C+Medical+Imaging+Conference+and+15th+International+Room+Temperature+Semiconductor+Detector+Workshop&rft.issn=&rft_id=info:doi/ L2 - http://www.nss-mic.org/2006/program/ProgramBook1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Light Decay Time/gain Shift in a LaBr(3):Ce/LYSO:Ce Phoswich Detector T2 - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AN - 40498331; 4503107 JF - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AU - Green, M V AU - Seidel, J AU - Choyke, P AU - Xi, W. Y1 - 2006/10/29/ PY - 2006 DA - 2006 Oct 29 KW - Decay KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40498331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NTP+CERHR+MON&rft.atitle=NTP-CERHR+monograph+on+the+potential+human+reproductive+and+developmental+effects+of+di+%282-ethylhexyl%29+phthalate+%28DEHP%29.&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2006-11-01&rft.volume=&rft.issue=18&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=NTP+CERHR+MON&rft.issn=15562271&rft_id=info:doi/ L2 - http://www.nss-mic.org/2006/program/ProgramBook1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1. AN - 68981260; 16945929 AB - The laminin alpha1 chain is a subunit of laminin-1, a heterotrimeric basement membrane protein. The LG4-5 module at the C terminus of laminin alpha1 contains major binding sites for heparin, sulfatide, and alpha-dystroglycan and plays a critical role in early embryonic development. We previously identified active synthetic peptides AG73 and EF-1 from the sequence of laminin alpha1 LG4 for binding to syndecan and integrin alpha2beta1, respectively. However, their activity and functional relationship within the laminin-1 and LG4 as well as the functional relation between these sites and alpha-dystroglycan binding sites in LG4 are not clear. To address these questions, we created mutant recombinant LG4 proteins containing alanine substitutions within the AG73 (M1), EF-1 (M2, M3), and alpha-dystroglycan binding sites (M4, M5) and analyzed their activities. We found that recombinant proteins rec-M1 and rec-M5, containing mutations within M1 and M5, respectively, did not bind heparin or lymphoid cell lines expressing syndecans. These results suggest that LG4 binds to heparin and syndecans through M1 and M5. Rec-M1 and rec-M5 reduced fibroblast attachment, whereas mutant rec-M2 and rec-M3 retained cell attachment activity but did not promote cell spreading. Fibroblast attachment to rec-LG4 was inhibited by heparin but not by integrin antibodies. Spreading of fibroblasts on rec-LG4 was inhibited by anti-integrin alpha2 and beta1 but not by anti-integrin alpha1 and alpha6. These results suggest that the M1 and M5 sites are necessary for cell attachment on LG4 through syndecans and that the EF-1 site is for cell spreading activity through integrin alpha2beta1. In contrast, laminin-1-mediated fibroblast attachment and spreading were not inhibited by heparin or anti-integrin alpha2. Our findings indicate that LG4 has a unique function distinct from laminin-1 and suggest that laminin alpha1 LG4-5 may also be produced by a proteolytic cleavage in certain tissues where it exerts its activity. JF - The Journal of biological chemistry AU - Hozumi, Kentaro AU - Suzuki, Nobuharu AU - Nielsen, Peter K AU - Nomizu, Motoyoshi AU - Yamada, Yoshihiko AD - Molecular Biology Section, Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, MD 20892-4370, USA. Y1 - 2006/10/27/ PY - 2006 DA - 2006 Oct 27 SP - 32929 EP - 32940 VL - 281 IS - 43 SN - 0021-9258, 0021-9258 KW - Integrin alpha2beta1 KW - 0 KW - Laminin KW - Recombinant Proteins KW - Syndecans KW - laminin A KW - 151186-83-3 KW - Heparin KW - 9005-49-6 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Epithelial Cells -- physiology KW - Humans KW - Mice KW - Binding Sites KW - Fibroblasts -- physiology KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Fluorescent Antibody Technique, Direct KW - Recombinant Proteins -- metabolism KW - Alanine -- metabolism KW - Cells, Cultured KW - Skin -- cytology KW - Heparin -- metabolism KW - Recombinant Proteins -- chemistry KW - Male KW - Amino Acid Substitution KW - Cell Line KW - Cell Adhesion KW - Laminin -- chemistry KW - Laminin -- metabolism KW - Syndecans -- metabolism KW - Laminin -- genetics KW - Cell Movement -- physiology KW - Integrin alpha2beta1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68981260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Laminin+alpha1+chain+LG4+module+promotes+cell+attachment+through+syndecans+and+cell+spreading+through+integrin+alpha2beta1.&rft.au=Hozumi%2C+Kentaro%3BSuzuki%2C+Nobuharu%3BNielsen%2C+Peter+K%3BNomizu%2C+Motoyoshi%3BYamada%2C+Yoshihiko&rft.aulast=Hozumi&rft.aufirst=Kentaro&rft.date=2006-10-27&rft.volume=281&rft.issue=43&rft.spage=32929&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of MTHFR gene polymorphisms with breast cancer survival. AN - 68120626; 17069650 AB - Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women. African-American (n = 143) and Caucasian (n = 105) women, who had incident breast cancer with surgery, were recruited between 1993 and 2003 from the greater Baltimore area, Maryland, USA. Kaplan-Meier survival and multivariate Cox proportional hazards regression analyses were used to examine the relationship between MTHFR SNPs and disease-specific survival. We observed opposite effects of the MTHFR polymorphisms A1298C and C677T on breast cancer survival. Carriers of the variant allele at codon 1298 (A/C or C/C) had reduced survival when compared to homozygous carriers of the common A allele [Hazard ratio (HR) = 2.05; 95% confidence interval (CI), 1.05-4.00]. In contrast, breast cancer patients with the variant allele at codon 677 (C/T or T/T) had improved survival, albeit not statistically significant, when compared to individuals with the common C/C genotype (HR = 0.65; 95% CI, 0.31-1.35). The effects were stronger in patients with estrogen receptor-negative tumors (HR = 2.70; 95% CI, 1.17-6.23 for A/C or C/C versus A/A at codon 1298; HR = 0.36; 95% CI, 0.12-1.04 for C/T or T/T versus C/C at codon 677). Interactions between the two MTHFR genotypes and race/ethnicity on breast cancer survival were also observed (A1298C, pinteraction = 0.088; C677T, pinteraction = 0.026). We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival. The variant alleles had opposite effects on disease outcome in the study population. Race/ethnicity modified the association between the two SNPs and breast cancer survival. JF - BMC cancer AU - Martin, Damali N AU - Boersma, Brenda J AU - Howe, Tiffany M AU - Goodman, Julie E AU - Mechanic, Leah E AU - Chanock, Stephen J AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. martinda@mail.nih.gov Y1 - 2006/10/27/ PY - 2006 DA - 2006 Oct 27 SP - 257 VL - 6 KW - Cytosine KW - 8J337D1HZY KW - Methylenetetrahydrofolate Reductase (NADPH2) KW - EC 1.5.1.20 KW - Adenine KW - JAC85A2161 KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Genotype KW - Odds Ratio KW - Humans KW - Middle Aged KW - African Americans -- genetics KW - European Continental Ancestry Group -- genetics KW - Female KW - Survival Analysis KW - Proportional Hazards Models KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- ethnology KW - Methylenetetrahydrofolate Reductase (NADPH2) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68120626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Association+of+MTHFR+gene+polymorphisms+with+breast+cancer+survival.&rft.au=Martin%2C+Damali+N%3BBoersma%2C+Brenda+J%3BHowe%2C+Tiffany+M%3BGoodman%2C+Julie+E%3BMechanic%2C+Leah+E%3BChanock%2C+Stephen+J%3BAmbs%2C+Stefan&rft.aulast=Martin&rft.aufirst=Damali&rft.date=2006-10-27&rft.volume=6&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2004 Jan 26;90(2):526-34 [14735204] Trends Pharmacol Sci. 2001 Apr;22(4):195-201 [11282420] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):190-6 [14973091] Adv Drug Deliv Rev. 2004 Apr 29;56(8):1067-84 [15094207] J Nutr. 2004 Jul;134(7):1786-92 [15226470] Breast Cancer Res. 2004;6(5):192-200 [15318924] Ann Rheum Dis. 2004 Oct;63(10):1227-31 [15361376] Annu Rev Med. 1982;33:345-54 [6805415] Cancer Detect Prev. 1985;8(1-2):71-5 [4064054] J Natl Cancer Inst. 1994 May 4;86(9):705-12 [7908990] Nat Genet. 1995 May;10(1):111-3 [7647779] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3290-5 [9096386] Mol Genet Metab. 1998 Jul;64(3):169-72 [9719624] Am J Clin Nutr. 1999 Mar;69(3):476-81 [10075333] J Clin Oncol. 2004 Nov 15;22(22):4632-42 [15542813] Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2071-7 [15598763] Cancer Res. 2005 Feb 15;65(4):1606-14 [15735051] Atherosclerosis. 2001 Jun;156(2):409-15 [11395038] Epidemiology. 2001 Jul;12(4):420-8 [11416780] Cancer Res. 2001 Aug 15;61(16):5979-84 [11507038] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14853-8 [11742092] Pharmacogenetics. 2002 Apr;12(3):181-2 [11927832] Pharmacogenetics. 2002 Apr;12(3):183-90 [11927833] Pharmacogenetics. 2002 Jun;12(4):339-42 [12042673] Cancer Res. 2002 Aug 1;62(15):4519-24 [12154064] Cancer Lett. 2002 Jul 8;181(1):65-71 [12430180] Int J Cancer. 2003 Jan 20;103(3):294-9 [12471611] Breast Cancer Res. 2002;4(6):R14 [12473175] J Hum Genet. 2003;48(1):1-7 [12560871] J Natl Cancer Inst. 2003 Mar 5;95(5):373-80 [12618502] Nutr Cancer. 2002;44(2):139-44 [12734059] Cancer Res. 2003 Jun 1;63(11):2820-8 [12782587] Breast Cancer Res Treat. 2003 Sep;81(2):169-72 [14572159] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Clin Cancer Res. 2005 Mar 15;11(6):2156-62 [15788661] Breast Cancer Res Treat. 2005 May;91(1):73-9 [15868433] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2004-8 [16103452] Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):3015-8 [16365030] Cancer Chemother Pharmacol. 2006 Jul;58(1):1-12 [16362298] J Natl Cancer Inst. 2006 Jul 5;98(13):911-9 [16818855] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12216-8 [10535898] Ann Oncol. 2000 Mar;11(3):373-4 [10811509] Hum Mol Genet. 2001 Mar 1;10(5):433-43 [11181567] J Natl Cancer Inst. 2004 Jan 21;96(2):134-44 [14734703] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Endocannabinoid System and Cardiovascular Risk Factors T2 - 2006 World Congress on Controversies in Obesity, Diabetes and Hypertension AN - 40484504; 4491487 JF - 2006 World Congress on Controversies in Obesity, Diabetes and Hypertension AU - Kunos, G Y1 - 2006/10/26/ PY - 2006 DA - 2006 Oct 26 KW - Cannabinoids KW - Cardiovascular diseases KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40484504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Congress+on+Controversies+in+Obesity%2C+Diabetes+and+Hypertension&rft.atitle=The+Endocannabinoid+System+and+Cardiovascular+Risk+Factors&rft.au=Kunos%2C+G&rft.aulast=Kunos&rft.aufirst=G&rft.date=2006-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Congress+on+Controversies+in+Obesity%2C+Diabetes+and+Hypertension&rft.issn=&rft_id=info:doi/ L2 - http://www.codhy.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The American Nuclear Renaissance: Today and Tomorrow T2 - 2006 Annual Meeting and Exposition of the Geological Society of America (GSA 2006) AN - 40313839; 4404327 JF - 2006 Annual Meeting and Exposition of the Geological Society of America (GSA 2006) AU - Howard, Angelina S Y1 - 2006/10/22/ PY - 2006 DA - 2006 Oct 22 KW - USA KW - Energy resources KW - Policies KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40313839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Exposition+of+the+Geological+Society+of+America+%28GSA+2006%29&rft.atitle=The+American+Nuclear+Renaissance%3A+Today+and+Tomorrow&rft.au=Howard%2C+Angelina+S&rft.aulast=Howard&rft.aufirst=Angelina&rft.date=2006-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Exposition+of+the+Geological+Society+of+America+%28GSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://gsa.confex.com/gsa/2006AM/finalprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. AN - 68866419; 16945340 AB - Development of Grb2-SH2 domain antagonists is considered to be an effective and non-cytotoxic strategy to develop new antiproliferative agents because of their potential to shut down the Ras signaling pathway. We developed a concise route for the efficient synthesis of G1TE analogs on solid phase. Using this route, a series of cyclic peptides that do not rely on phosphotyrosine or its mimics were designed and synthesized based upon the phage library-derived cyclopeptide, G1TE. Considering that Gly7 plays prominent roles for G1TE binding to the Grb2-SH2 domain, we introduced different amino acids in the 7th position. The D-Ala7-containing peptide 3 demonstrates improved binding affinity by adopting favorable conformation for protein binding. This can be rationalized by molecular modeling. The optimization at the Leu2 position was also studied, and the resulting cyclopeptides exhibited remarkably improved binding affinity. Based upon these global modifications, a highly potent peptide ligand 9 was discovered with a Kd = 17 nM, evaluated by Biacore binding assay. This new analog is one of the most potent non-phosphorus-containing Grb2-SH2 antagonists reported to date. This potent peptidomimetic provides a new template for the development of non-pTyr containing Grb2-SH2 domain antagonists and acts as a chemotherapeutic lead for the treatment of erbB2-related cancer. JF - Biochemical and biophysical research communications AU - Jiang, Sheng AU - Li, Peng AU - Peach, Megan L AU - Bindu, Lakshman AU - Worthy, Karen W AU - Fisher, Robert J AU - Burke, Terrence R AU - Nicklaus, Marc AU - Roller, Peter P AD - Laboratory of Medicinal Chemistry, NCI, NIH, Frederick, MD 21702, USA. Y1 - 2006/10/20/ PY - 2006 DA - 2006 Oct 20 SP - 497 EP - 503 VL - 349 IS - 2 SN - 0006-291X, 0006-291X KW - GRB2 Adaptor Protein KW - 0 KW - Peptides KW - Phosphotyrosine KW - 21820-51-9 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Humans KW - Peptides -- chemistry KW - Mice KW - Alanine -- chemistry KW - Inhibitory Concentration 50 KW - Protein Binding KW - Protein-Tyrosine Kinases -- chemistry KW - src Homology Domains KW - Phosphotyrosine -- chemistry KW - Chemistry, Pharmaceutical -- methods KW - Drug Design KW - GRB2 Adaptor Protein -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68866419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Structure-based+design+of+potent+Grb2-SH2+domain+antagonists+not+relying+on+phosphotyrosine+mimics.&rft.au=Jiang%2C+Sheng%3BLi%2C+Peng%3BPeach%2C+Megan+L%3BBindu%2C+Lakshman%3BWorthy%2C+Karen+W%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R%3BNicklaus%2C+Marc%3BRoller%2C+Peter+P&rft.aulast=Jiang&rft.aufirst=Sheng&rft.date=2006-10-20&rft.volume=349&rft.issue=2&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-30 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prions and their partners in crime. AN - 68970486; 17051207 AB - Prions, the infectious agents of transmissible spongiform encephalopathies (TSEs), have defied full characterization for decades. The dogma has been that prions lack nucleic acids and are composed of a pathological, self-inducing form of the host's prion protein (PrP). Recent progress in propagating TSE infectivity in cell-free systems has effectively ruled out the involvement of foreign nucleic acids. However, host-derived nucleic acids or other non-PrP molecules seem to be crucial. Interactions between TSE-associated PrP and its normal counterpart are also pathologically important, so the physiological functions of normal PrP and how they might be corrupted by TSE infections have been the subject of recent research. JF - Nature AU - Caughey, Byron AU - Baron, Gerald S AD - National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA. bcaughey@nih.gov Y1 - 2006/10/19/ PY - 2006 DA - 2006 Oct 19 SP - 803 EP - 810 VL - 443 IS - 7113 KW - Glycosylphosphatidylinositols KW - 0 KW - Ligands KW - Prions KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Animals KW - Humans KW - Copper -- metabolism KW - Glycosylphosphatidylinositols -- metabolism KW - Copper -- pharmacology KW - Prions -- toxicity KW - Prions -- chemistry KW - Prion Diseases -- metabolism KW - Prion Diseases -- physiopathology KW - Prion Diseases -- genetics KW - Prion Diseases -- pathology KW - Prions -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Prions+and+their+partners+in+crime.&rft.au=Caughey%2C+Byron%3BBaron%2C+Gerald+S&rft.aulast=Caughey&rft.aufirst=Byron&rft.date=2006-10-19&rft.volume=443&rft.issue=7113&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. AN - 68970208; 16702950 AB - The overexpression or mutation of tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR), can lead to the development of cancer. The most common mutation of the EGFR in glioblastomas is the deletion of exons 2-7 known as the EGFRvIII. This mutant receptor cannot bind EGF but, instead, is constitutively active. The Cbl family of ubiquitin ligases (Cbl, Cbl-b, and Cbl-c) targets the activated EGFR for degradation. As the EGFRvIII is transforming, we investigated whether it could be downregulated by the Cbl proteins. The overexpression of all three Cbl proteins resulted in the ubiquitination and degradation of the EGFRvIII. As with the wild-type EGFR, the TK-binding domain and the RING finger of Cbl-b are sufficient for the downregulation of the EGFRvIII. Also, we found that Cbl-b is recruited to the EGFRvIII and inhibits the transformation of NIH 3T3 cells by the EGFRvIII. Mutation of the Cbl-binding site (Y1045F) in the EGFRvIII inhibits its ubiquitination and downregulation by Cbl-b and enhances its ability to transform. Furthermore, the EGFR TK inhibitor, AG 1478, prevents the downregulation of the EGFRvIII by the Cbl proteins and antagonizes the ability of an immunotoxin directed against the EGFRvIII to kill cells expressing this receptor. In conclusion, the EGFRvIII does not transform by escaping regulation by Cbl proteins and this activation-induced downregulation of the EGFRvIII has an important role in mediating the toxicity of anti-EGFRvIII immunotoxins. JF - Oncogene AU - Davies, G C AU - Ryan, P E AU - Rahman, L AU - Zajac-Kaye, M AU - Lipkowitz, S AD - Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/10/19/ PY - 2006 DA - 2006 Oct 19 SP - 6497 EP - 6509 VL - 25 IS - 49 SN - 0950-9232, 0950-9232 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Quinazolines KW - Tyrphostins KW - Ubiquitin KW - epidermal growth factor receptor VIII KW - tyrphostin AG 1478 KW - 170449-18-0 KW - Proto-Oncogene Proteins c-cbl KW - EC 2.3.2.27 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Cblb protein, mouse KW - EC 6.3.2.19 KW - Index Medicus KW - Animals KW - Humans KW - Protein Processing, Post-Translational KW - Mice KW - Protein Binding KW - NIH 3T3 Cells KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Ubiquitin -- metabolism KW - Cell Survival -- drug effects KW - Down-Regulation KW - Transfection KW - Cells, Cultured KW - CHO Cells KW - Tyrphostins -- pharmacology KW - Cell Transformation, Neoplastic KW - Cricetinae KW - Proto-Oncogene Proteins c-cbl -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=EGFRvIII+undergoes+activation-dependent+downregulation+mediated+by+the+Cbl+proteins.&rft.au=Davies%2C+G+C%3BRyan%2C+P+E%3BRahman%2C+L%3BZajac-Kaye%2C+M%3BLipkowitz%2C+S&rft.aulast=Davies&rft.aufirst=G&rft.date=2006-10-19&rft.volume=25&rft.issue=49&rft.spage=6497&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Oct 29;274(44):31707-12 [10531381] N Engl J Med. 2005 Nov 10;353(19):2012-24 [16282176] Cancer Res. 2000 Jun 1;60(11):3081-7 [10850460] Clin Cancer Res. 2000 Jul;6(7):2835-43 [10914732] Mol Cell Biol Res Commun. 1999 Aug;2(2):111-8 [10542134] Int J Cancer. 2000 Dec 15;88(6):962-9 [11093822] Nature. 2001 May 17;411(6835):355-65 [11357143] J Biol Chem. 2001 Feb 16;276(7):5375-83 [11087732] Endocr Relat Cancer. 2001 Jun;8(2):83-96 [11397666] J Biol Chem. 2001 Jul 20;276(29):27677-84 [11375397] Ann Oncol. 2001 Jun;12(6):745-60 [11484948] Mol Cell. 2001 Nov;8(5):995-1004 [11741535] Int J Cancer. 2002 Jan 1;97(1):7-14 [11774237] EMBO J. 2002 Feb 1;21(3):303-13 [11823423] J Biol Chem. 2002 Apr 26;277(17):14635-40 [11847211] Int J Cancer. 2002 Sep 10;101(2):111-7 [12209987] Mol Biol Cell. 2003 Mar;14(3):858-70 [12631709] Gene. 2003 Apr 10;308:103-13 [12711395] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6505-10 [12734385] Cancer Cell. 2003 Jun;3(6):519-23 [12842080] J Biol Chem. 2003 Aug 1;278(31):28950-60 [12754251] Cancer Res. 2003 Oct 15;63(20):6962-70 [14583498] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15871-6 [14676326] Int J Cancer. 2004 Feb 20;108(5):643-53 [14696090] Oncogene. 2004 Aug 12;23(36):6095-104 [15221011] Oncogene. 2004 Sep 9;23(41):6967-79 [15273741] Proc Natl Acad Sci U S A. 1977 Sep;74(9):3918-21 [302945] Annu Rev Biochem. 1992;61:331-54 [1497314] Cancer Res. 1993 Jul 15;53(14):3217-20 [8391918] Oncogene. 1994 Aug;9(8):2313-20 [8036013] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7727-31 [8052651] Cell. 1994 Sep 9;78(5):787-98 [8087846] Cancer Res. 1995 Jul 15;55(14):3140-8 [7606735] Cancer Res. 1995 Oct 1;55(19):4375-82 [7671250] Cancer Res. 1995 Dec 1;55(23):5536-9 [7585629] Cell Growth Differ. 1995 Oct;6(10):1251-9 [8845302] Oncogene. 1996 Jul 4;13(1):85-96 [8700557] Cancer Res. 1996 Sep 1;56(17):3859-61 [8752145] Cancer Res. 1996 Oct 15;56(20):4791-8 [8841000] Cancer Res. 1996 Nov 1;56(21):5079-86 [8895767] J Biol Chem. 1997 Jan 31;272(5):2927-35 [9006938] J Biol Chem. 1998 Jan 30;273(5):2817-22 [9446590] Oncogene. 1998 Mar 5;16(9):1197-207 [9528862] Oncogene. 1999 Mar 11;18(10):1855-66 [10086340] Oncogene. 1999 Jun 3;18(22):3365-75 [10362357] EMBO J. 1999 Jun 15;18(12):3348-58 [10369675] J Biol Chem. 1999 Aug 6;274(32):22151-4 [10428778] Clin Cancer Res. 2005 Feb 15;11(4):1462-6 [15746047] Mol Cell. 1999 Dec;4(6):1029-40 [10635327] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. AN - 68966632; 17024177 AB - Hypoxia promotes genetic instability for tumor progression. Recent evidence indicates that the transcription factor HIF-1alpha impairs DNA mismatch repair, yet the role of HIF-1alpha isoform, HIF-2alpha, in tumor progression remains obscure. In pursuit of the involvement of HIF-alpha in chromosomal instability, we report here that HIF-1alpha, specifically its PAS-B, induces DNA double-strand breaks at least in part by repressing the expression of NBS1, a crucial DNA repair gene constituting the MRE11A-RAD50-NBS1 complex. Despite strong similarities between the two isoforms, HIF-2alpha fails to do so. We demonstrate that this functional distinction stems from phosphorylation of HIF-2alpha Thr-324 by protein kinase D1, which discriminates between subtle differences of the two PAS-B in amino-acid sequence, thereby precluding NBS1 repression. Hence, our findings delineate a molecular pathway that functionally distinguishes HIF-1alpha from HIF-2alpha, and arguing a unique role for HIF-1alpha in tumor progression by promoting genomic instability. JF - The EMBO journal AU - To, Kenneth K-W AU - Sedelnikova, Olga A AU - Samons, Melissa AU - Bonner, William M AU - Huang, L Eric AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10/18/ PY - 2006 DA - 2006 Oct 18 SP - 4784 EP - 4794 VL - 25 IS - 20 SN - 0261-4189, 0261-4189 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Cell Cycle Proteins KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Multiprotein Complexes KW - NBN protein, human KW - Neoplasm Proteins KW - Nuclear Proteins KW - endothelial PAS domain-containing protein 1 KW - Index Medicus KW - DNA Repair -- genetics KW - Animals KW - Protein Structure, Tertiary -- genetics KW - Multiprotein Complexes -- genetics KW - Phosphorylation KW - Down-Regulation -- genetics KW - Humans KW - Protein Processing, Post-Translational KW - Rabbits KW - Cell Line KW - Multiprotein Complexes -- metabolism KW - Nuclear Proteins -- genetics KW - Chromosomal Instability -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Neoplasms -- genetics KW - Cell Cycle Proteins -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Cell Cycle Proteins -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Neoplasm Proteins -- genetics KW - Nuclear Proteins -- metabolism KW - Neoplasm Proteins -- metabolism KW - Gene Expression Regulation, Neoplastic -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68966632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=The+phosphorylation+status+of+PAS-B+distinguishes+HIF-1alpha+from+HIF-2alpha+in+NBS1+repression.&rft.au=To%2C+Kenneth+K-W%3BSedelnikova%2C+Olga+A%3BSamons%2C+Melissa%3BBonner%2C+William+M%3BHuang%2C+L+Eric&rft.aulast=To&rft.aufirst=Kenneth&rft.date=2006-10-18&rft.volume=25&rft.issue=20&rft.spage=4784&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2003 Jan;23(1):359-69 [12482987] Mol Cell Biol. 2002 Mar;22(6):1834-43 [11865061] J Biol Chem. 2003 Apr 4;278(14):12207-13 [12519769] Mol Cell Biol. 2003 May;23(9):3265-73 [12697826] J Biol Chem. 2003 May 16;278(20):17969-76 [12637538] J Biol Chem. 2003 May 23;278(21):19286-91 [12637527] J Biol Chem. 2003 May 30;278(22):19575-8 [12639949] Nat Med. 2003 Jun;9(6):677-84 [12778166] FEBS Lett. 2003 Jul 3;546(1):81-6 [12829240] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Nat Rev Drug Discov. 2003 Oct;2(10):803-11 [14526383] Mol Cell Biol. 2003 Dec;23(24):9361-74 [14645546] Nat Genet. 2003 Dec;35(4):331-40 [14608355] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15504-9 [14668441] Curr Opin Genet Dev. 2004 Feb;14(1):81-5 [15108809] EMBO J. 2004 May 5;23(9):1949-56 [15071503] Nat Med. 2004 Aug;10(8):789-99 [15286780] Genes Dev. 2004 Sep 1;18(17):2095-107 [15314031] Mol Cell Biol. 2004 Oct;24(19):8504-18 [15367671] Cancer Res. 2004 Sep 15;64(18):6556-62 [15374968] Drug Discov Today. 2004 Oct 15;9(20):869 [15493075] Nat Rev Mol Cell Biol. 2002 May;3(5):317-27 [11988766] Cancer Cell. 2002 Apr;1(3):237-46 [12086860] Cancer Cell. 2002 Apr;1(3):247-55 [12086861] Nat Med. 2002 Jul;8(7):702-10 [12053176] Nature. 2002 Jul 18;418(6895):348-52 [12124628] FASEB J. 2002 Aug;16(10):1151-62 [12153983] J Biol Chem. 2002 Nov 1;277(44):41750-5 [12205091] Curr Biol. 2002 Oct 29;12(21):1846-51 [12419185] Nature. 2002 Nov 7;420(6911):93-8 [12422221] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Cell. 1998 May 1;93(3):467-76 [9590180] Cell. 1998 May 1;93(3):477-86 [9590181] Nat Genet. 1998 Jun;19(2):179-81 [9620777] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92 [9653127] Nature. 1998 Jul 30;394(6692):485-90 [9697772] Mol Cell. 1998 Aug;2(2):259-65 [9734364] Blood. 1998 Oct 1;92(7):2260-8 [9746763] Genes Dev. 1998 Nov 1;12(21):3320-4 [9808618] Nature. 1998 Dec 17;396(6712):643-9 [9872311] J Cell Biol. 1999 Sep 6;146(5):905-16 [10477747] Mutat Res. 2005 Jan 6;569(1-2):75-85 [15603753] Cancer Res. 2005 Mar 15;65(6):2277-86 [15781641] Mol Cell. 2005 Mar 18;17(6):793-803 [15780936] Nat Med. 2005 May;11(5):538-44 [15821748] Mol Cell Biol. 2005 Jun;25(11):4565-78 [15899860] Annu Rev Biochem. 2005;74:115-28 [15952883] Mol Cell Biol. 2005 Jul;25(13):5675-86 [15964822] Cancer Cell. 2005 Aug;8(2):131-41 [16098466] Cell Cycle. 2005 Jul;4(7):881-2 [15970707] Cancer Res. 2005 Dec 15;65(24):11597-604 [16357170] Genes Dev. 2006 Mar 1;20(5):557-70 [16510872] Cell Metab. 2006 Mar;3(3):177-85 [16517405] Cell Metab. 2006 Mar;3(3):187-97 [16517406] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Am J Pathol. 2000 Aug;157(2):411-21 [10934146] Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95 [10959836] Nature. 2000 Nov 23;408(6811):433-9 [11100718] J Cell Biol. 2000 Dec 25;151(7):1381-90 [11134068] Cancer Res. 2000 Dec 15;60(24):7106-13 [11156418] Nat Biotechnol. 2001 Apr;19(4):348-53 [11283593] J Biol Chem. 2001 Feb 2;276(5):3550-4 [11063749] Nature. 2003 Jan 23;421(6921):436-40 [12540918] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality. AN - 68968802; 17047075 AB - Persistent cervical infections with carcinogenic human papillomaviruses (HPV) cause virtually all cervical cancer. Cytologic abnormalities are the manifestations of HPV infections used to identify women at risk. To compare the potential of the full range of anogenital HPV genotypes to induce cytopathic effects, we examined the influences of HPV type, viral load, and age on cytopathology among 1,222 women having a single HPV type at enrollment into a 10,000-woman population-based study in Costa Rica. Cervical specimens were tested for approximately 40 HPV types by MY09/MY11 L1 primer PCR and type-specific dot blot hybridization. Types were organized by phylogenetic species and cancer risk. PCR signal strength served as a qualitative surrogate for viral load. Overall, 24.8% [95% confidence interval (95% CI), 22.4-27.3] of single prevalent HPV infections had concurrent abnormalities (atypical squamous cells or worse) ranging from 0.0% to 80.0% based on HPV type. Noncarcinogenic alpha3/alpha15 types, although highly prevalent, uncommonly caused cytologic abnormalities (13.1%; 95% CI, 9.8-17.0). In contrast, one quarter to nearly one half of infections with a single major carcinogenic species type (alpha9/alpha11/alpha7/alpha5/alpha6) produced abnormalities. Greater abnormalities were observed with increasing qualitative viral load of carcinogenic types; fewer abnormalities were observed among older women (>54 years). A high percentage (46.2%) of detected abnormalities in women infected with HPV16 or related alpha9 types were high grade or worse, consistent with strong carcinogenicity, compared with 10.7% in women infected with alpha7 types, including HPV18, a major cause of adenocarcinoma. The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions. JF - Cancer research AU - Kovacic, Melinda Butsch AU - Castle, Philip E AU - Herrero, Rolando AU - Schiffman, Mark AU - Sherman, Mark E AU - Wacholder, Sholom AU - Rodriguez, Ana C AU - Hutchinson, Martha L AU - Bratti, M Concepción AU - Hildesheim, Allan AU - Morales, Jorge AU - Alfaro, Mario AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. kovacicm@mail.nih.gov Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 10112 EP - 10119 VL - 66 IS - 20 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Cervix Uteri -- pathology KW - Age Factors KW - Cervical Intraepithelial Neoplasia -- pathology KW - Humans KW - Viral Load KW - Uterine Cervical Neoplasms -- epidemiology KW - Adult KW - Cohort Studies KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervix Uteri -- virology KW - Middle Aged KW - Costa Rica -- epidemiology KW - Uterine Cervical Neoplasms -- pathology KW - Female KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Uterine Cervical Diseases -- virology KW - Uterine Cervical Diseases -- pathology KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics KW - Uterine Cervical Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Relationships+of+human+papillomavirus+type%2C+qualitative+viral+load%2C+and+age+with+cytologic+abnormality.&rft.au=Kovacic%2C+Melinda+Butsch%3BCastle%2C+Philip+E%3BHerrero%2C+Rolando%3BSchiffman%2C+Mark%3BSherman%2C+Mark+E%3BWacholder%2C+Sholom%3BRodriguez%2C+Ana+C%3BHutchinson%2C+Martha+L%3BBratti%2C+M+Concepci%C3%B3n%3BHildesheim%2C+Allan%3BMorales%2C+Jorge%3BAlfaro%2C+Mario%3BBurk%2C+Robert+D&rft.aulast=Kovacic&rft.aufirst=Melinda&rft.date=2006-10-15&rft.volume=66&rft.issue=20&rft.spage=10112&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. AN - 68916930; 16963468 AB - The dopamine transporter gene (SLC6A3) is a candidate gene for Parkinson's disease (PD) on the basis of its critical role in dopaminergic neurotransmission. Previously, we identified 22 SNPs in the 5' region of SLC6A3, which segregate as eight haplotypes that differ in transcriptional activity when transfected in rat dopamine-producing cells. In the present work from a case-control study size of 293 cases and 395 controls, we employed a cladistic approach to examine gene-disease association. First, we found strong evidence of balancing selection in this region, as determined by a Tajima's D statistic of 2.97 (P<0.001). Second, we found that the eight haplotypes fit into two main clades and that diplotypes of these clades were marginally associated with PD. Then, after we classified cases and controls by the number of risk alleles, accounting for the well-known 3' region VNTR polymorphism, we found that having two or more risk alleles resulted in a modest but significant increase in PD risk [odds ratio=1.58; 95% confidence interval (CI): 1.03-2.40]. Finally, we detected a significant interaction between occupational pesticide exposure in men and the number of risk alleles. Among pesticide-exposed subjects, the odds ratio for having two or more risk alleles was 5.66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk. JF - Human molecular genetics AU - Kelada, Samir N P AU - Checkoway, Harvey AU - Kardia, Sharon L R AU - Carlson, Christopher S AU - Costa-Mallen, Paola AU - Eaton, David L AU - Firestone, Jordan AU - Powers, Karen M AU - Swanson, Phillip D AU - Franklin, Gary M AU - Longstreth, W T AU - Weller, Terri-Smith AU - Afsharinejad, Zahra AU - Costa, Lucio G AD - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA. keladas@mail.nih.gov Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 3055 EP - 3062 VL - 15 IS - 20 SN - 0964-6906, 0964-6906 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Pesticides KW - SLC6A3 protein, human KW - Index Medicus KW - Minisatellite Repeats KW - Polymorphism, Single Nucleotide KW - 3' Flanking Region -- genetics KW - Haplotypes KW - Humans KW - Case-Control Studies KW - 5' Flanking Region -- genetics KW - Male KW - Female KW - Occupational Exposure KW - Dopamine Plasma Membrane Transport Proteins -- genetics KW - Parkinson Disease -- physiopathology KW - Genetic Predisposition to Disease KW - Parkinson Disease -- genetics KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68916930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=CT+Colonography+with+Computer-aided+Polyp+Detection%3A+Volume+and+Attenuation+Thresholds+to+Reduce+False-Positive+Findings+Owing+to+the+Ileocecal+Valve&rft.au=O%27Connor%2C+Stacy+D%3BSummers%2C+Ronald+M%3BYao%2C+Jianhua%3BPickhardt%2C+Perry+J%3BChoi%2C+JRichard&rft.aulast=O%27Connor&rft.aufirst=Stacy&rft.date=2006-11-01&rft.volume=241&rft.issue=2&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ni(II) affects ubiquitination of core histones H2B and H2A. AN - 68880757; 16870173 AB - The molecular mechanisms of nickel-induced malignant cell transformation include effects altering the structure and covalent modifications of core histones. Previously, we found that exposure of cells to Ni(II) resulted in truncation of histones H2A and H2B and thus elimination of some modification sites. Here, we investigated the effect of Ni(II) on one such modification, ubiquitination, of histones H2B and H2A in nuclei of cultured 1HAEo- and HPL1D human lung cells. After 1-5 days of exposure, Ni(II) up to 0.25 mM stimulated mono-ubiquitination of both histones, while at higher concentrations a suppression was found. Di-ubiquitination of H2A was not affected except for a drop after 5 days at 0.5 mM Ni(II). The decrease in mono-ubiquitination coincided with the appearance of truncated H2B that lacks the K120 ubiquitination site. However, prevention of truncation did not avert the decrease of H2B ubiquitination, indicating mechanistic independence of these effects. The changes in H2B ubiquitination did not fully coincide with concurrent changes in the nuclear levels of the ubiquitin-conjugating enzymes Rad6 and UbcH6. Overall, our results suggest that dysregulation of H2B ubiquitination is a part of Ni(II) adverse effects on gene expression and DNA repair which may assist in cell transformation. JF - Experimental cell research AU - Karaczyn, Aldona A AU - Golebiowski, Filip AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 3252 EP - 3259 VL - 312 IS - 17 SN - 0014-4827, 0014-4827 KW - Histones KW - 0 KW - Ubiquitin KW - Nickel KW - 7OV03QG267 KW - UBE2E1 protein, human KW - EC 2.3.2.23 KW - Ubiquitin-Conjugating Enzymes KW - Index Medicus KW - Ubiquitin-Conjugating Enzymes -- metabolism KW - Methylation -- drug effects KW - Humans KW - Lung -- cytology KW - Cell Transformation, Neoplastic -- drug effects KW - Cell Line KW - Ubiquitin -- metabolism KW - Histones -- metabolism KW - Nickel -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68880757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Ni%28II%29+affects+ubiquitination+of+core+histones+H2B+and+H2A.&rft.au=Karaczyn%2C+Aldona+A%3BGolebiowski%2C+Filip%3BKasprzak%2C+Kazimierz+S&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2006-10-15&rft.volume=312&rft.issue=17&rft.spage=3252&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Expression of Matrix Metalloproteinases and C-Kit Protein (CD 117) in Mesenchymal Tumours of the Uterus (MTU) T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40384477; 4430669 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Corrado, G AU - Carosi, M AU - Nonno, F Del AU - Vizza, E AU - Vocaturo, G AU - Licci, S AU - Brenna, A AU - Cione, A AU - Marandino, F AU - Perrone Donnorso, R. AU - Sbiroli, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Uterus KW - Tumors KW - C-Kit protein KW - Matrix metalloproteinase KW - Mesenchyme KW - Cadmium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40384477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Expression+of+Matrix+Metalloproteinases+and+C-Kit+Protein+%28CD+117%29+in+Mesenchymal+Tumours+of+the+Uterus+%28MTU%29&rft.au=Corrado%2C+G%3BCarosi%2C+M%3BNonno%2C+F+Del%3BVizza%2C+E%3BVocaturo%2C+G%3BLicci%2C+S%3BBrenna%2C+A%3BCione%2C+A%3BMarandino%2C+F%3BPerrone+Donnorso%2C+R.%3BSbiroli%2C+C&rft.aulast=Corrado&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Restaging Operations for Borderline Ovarian Tumors T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40383518; 4430049 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Figueiredo, E M AU - Gioia, S M AU - Moralez, G M AU - Silva, F H AU - Santiago, E G AU - Silva Neto, E L AU - Costa, R E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40383518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Impact+of+Restaging+Operations+for+Borderline+Ovarian+Tumors&rft.au=Figueiredo%2C+E+M%3BGioia%2C+S+M%3BMoralez%2C+G+M%3BSilva%2C+F+H%3BSantiago%2C+E+G%3BSilva+Neto%2C+E+L%3BCosta%2C+R+E&rft.aulast=Figueiredo&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Surgery for Recurrent Epithelial Ovarian Cancer after a Progression-Free Interval at Least Six Months T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40375568; 4430238 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Gioia, S M AU - Bizzo, S M AU - Lima, J M AU - Gouveia, G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Surgery KW - Ovarian cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40375568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Analysis+of+Surgery+for+Recurrent+Epithelial+Ovarian+Cancer+after+a+Progression-Free+Interval+at+Least+Six+Months&rft.au=Gioia%2C+S+M%3BBizzo%2C+S+M%3BLima%2C+J+M%3BGouveia%2C+G&rft.aulast=Gioia&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Coregulated Signalling Pathways in Microdissected Serous Ovarian Tumors T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40373986; 4430315 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Birrer, M AU - Bonome, T AU - Johnson, M E AU - Donninger, H AU - Wong, K K AU - Park, D C AU - Hao, K AU - Wong, W AU - Yip, D K AU - Welch, W R AU - Berkowitz, R S AU - Mok, S C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40373986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Identification+and+Characterization+of+Coregulated+Signalling+Pathways+in+Microdissected+Serous+Ovarian+Tumors&rft.au=Birrer%2C+M%3BBonome%2C+T%3BJohnson%2C+M+E%3BDonninger%2C+H%3BWong%2C+K+K%3BPark%2C+D+C%3BHao%2C+K%3BWong%2C+W%3BYip%2C+D+K%3BWelch%2C+W+R%3BBerkowitz%2C+R+S%3BMok%2C+S+C&rft.aulast=Birrer&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Amygdala Response to Emotional Faces in Major Depression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40373473; 4419579 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mah, L AU - Wood, S E AU - Furey, M L AU - Fromm, S J AU - Pine, D S AU - Drevets, W C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Depression KW - Amygdala KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40373473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+Amygdala+Response+to+Emotional+Faces+in+Major+Depression&rft.au=Mah%2C+L%3BWood%2C+S+E%3BFurey%2C+M+L%3BFromm%2C+S+J%3BPine%2C+D+S%3BDrevets%2C+W+C&rft.aulast=Mah&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic Radical Hysterectomy Type III in Treatment of Locally Advanced Cervical Cancer (LACC) after Neoadjuvant Chemotherapy (NACT) T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40371117; 4430440 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Vizza, E AU - Corrado, G AU - Ferretti, G AU - Canitano, S AU - Savarese, A AU - Vidiri, A AU - Costaggini, I AU - Baiocco, E AU - Sbiroli, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Chemotherapy KW - Cervical cancer KW - Radicals KW - Hysterectomy KW - Laparoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Laparoscopic+Radical+Hysterectomy+Type+III+in+Treatment+of+Locally+Advanced+Cervical+Cancer+%28LACC%29+after+Neoadjuvant+Chemotherapy+%28NACT%29&rft.au=Vizza%2C+E%3BCorrado%2C+G%3BFerretti%2C+G%3BCanitano%2C+S%3BSavarese%2C+A%3BVidiri%2C+A%3BCostaggini%2C+I%3BBaiocco%2C+E%3BSbiroli%2C+C&rft.aulast=Vizza&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucose Metabolism in Dorsal Versus Ventral Striatum Differentiates Major Depressive Subtypes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40371108; 4419578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Drevets, W C AU - Kupfer, D AU - Bogers, W AU - Thase, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glucose metabolism KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Glucose+Metabolism+in+Dorsal+Versus+Ventral+Striatum+Differentiates+Major+Depressive+Subtypes&rft.au=Drevets%2C+W+C%3BKupfer%2C+D%3BBogers%2C+W%3BThase%2C+M&rft.aulast=Drevets&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Categorization of Linguistic and Nonlinguistic Gestures: An fMRI Study using Deaf Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40371000; 4419549 JF - 36th Annual Meeting of the Society for Neuroscience AU - Husain, F T AU - Patkin, D AU - Braun, A R AU - Kim, J AU - Thai-Van, H AU - Horwitz, B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Language KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Categorization+of+Linguistic+and+Nonlinguistic+Gestures%3A+An+fMRI+Study+using+Deaf+Volunteers&rft.au=Husain%2C+F+T%3BPatkin%2C+D%3BBraun%2C+A+R%3BKim%2C+J%3BThai-Van%2C+H%3BHorwitz%2C+B&rft.aulast=Husain&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neonatal Offspring of VIP/PHI-Deficient Female Mice Exhibit Reduced Maternal Attachment T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40368744; 4417215 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lim, M A AU - Stone, M M AU - Waschek, J A AU - Hill, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Offspring KW - Mice KW - Progeny KW - Vasoactive intestinal peptide KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40368744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neonatal+Offspring+of+VIP%2FPHI-Deficient+Female+Mice+Exhibit+Reduced+Maternal+Attachment&rft.au=Lim%2C+M+A%3BStone%2C+M+M%3BWaschek%2C+J+A%3BHill%2C+J+M&rft.aulast=Lim&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microcirculatory Response to Forepaw Stimulation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40362100; 4419198 JF - 36th Annual Meeting of the Society for Neuroscience AU - Stefanovic, B AU - Hutchinson, E AU - Koretsky, A P AU - Silva, A C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Staining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40362100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Microcirculatory+Response+to+Forepaw+Stimulation&rft.au=Stefanovic%2C+B%3BHutchinson%2C+E%3BKoretsky%2C+A+P%3BSilva%2C+A+C&rft.aulast=Stefanovic&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging Nicotine-Induced Brain Signal Transduction Via Arachidonic Acid in Awake Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40361201; 4419044 JF - 36th Annual Meeting of the Society for Neuroscience AU - Nguyen, H N AU - Villacreses, N E AU - Chang, L AU - Rapoport, S I Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Rats KW - Neuroimaging KW - Arachidonic acid KW - Signal transduction KW - Imaging techniques KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+Nicotine-Induced+Brain+Signal+Transduction+Via+Arachidonic+Acid+in+Awake+Rats&rft.au=Nguyen%2C+H+N%3BVillacreses%2C+N+E%3BChang%2C+L%3BRapoport%2C+S+I&rft.aulast=Nguyen&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visually Specific Versus Category-Specific Regions in it Cortex of Awake Macaques Revealed by fMRI T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40360951; 4419085 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bell, A H AU - Hadj-Bouziane, F AU - Vanduffel, W AU - Ungerleider, L G AU - Tootell, R B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Cortex KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Visually+Specific+Versus+Category-Specific+Regions+in+it+Cortex+of+Awake+Macaques+Revealed+by+fMRI&rft.au=Bell%2C+A+H%3BHadj-Bouziane%2C+F%3BVanduffel%2C+W%3BUngerleider%2C+L+G%3BTootell%2C+R+B&rft.aulast=Bell&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synchronous Activity within and between Areas V4 and Fef in Attention T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40360950; 4419380 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Gotts, S J AU - Gregoriou, G G AU - Zhou, H AU - Desimone, R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synchronous+Activity+within+and+between+Areas+V4+and+Fef+in+Attention&rft.au=Gotts%2C+S+J%3BGregoriou%2C+G+G%3BZhou%2C+H%3BDesimone%2C+R&rft.aulast=Gotts&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - UCS Expectancy and Diminution of the Unconditioned fMRI Response during Pavlovian Fear Conditioning T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40359717; 4418961 JF - 36th Annual Meeting of the Society for Neuroscience AU - Knight, D C AU - Waters, N S AU - Bendettini, P A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Expectancy KW - UCS KW - Fear conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=UCS+Expectancy+and+Diminution+of+the+Unconditioned+fMRI+Response+during+Pavlovian+Fear+Conditioning&rft.au=Knight%2C+D+C%3BWaters%2C+N+S%3BBendettini%2C+P+A&rft.aulast=Knight&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Direct Current Polarization on Human Cortico-Cortical Excitation and Inhibition T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40359018; 4419403 JF - 36th Annual Meeting of the Society for Neuroscience AU - Iyer, M B AU - Lomarev, M AU - Hallett, M AU - Wassermann, E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Polarization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Direct+Current+Polarization+on+Human+Cortico-Cortical+Excitation+and+Inhibition&rft.au=Yang%2C+Sufen%3BYang%2C+Jun%3BYang%2C+Zhengqin%3BChen%2C+Posee%3BFraser%2C+Alison%3BZhang%2C+Wei%3BPang%2C+Hao%3BGao%2C+Xi%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Yang&rft.aufirst=Sufen&rft.date=2006-11-01&rft.volume=319&rft.issue=2&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclin-Dependent Kinase 5 Regulates Pain Signaling through Direct Phosphorylation of Trpv1 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358915; 4419387 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pareek, T K AU - Keller, J AU - Kesavapany, S AU - Agarwal, N AU - Kuner, R AU - Pant, H C AU - Iadarola, M J AU - Kulkarni, A B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Pain KW - Signal transduction KW - Capsaicin receptors KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cyclin-Dependent+Kinase+5+Regulates+Pain+Signaling+through+Direct+Phosphorylation+of+Trpv1&rft.au=Pareek%2C+T+K%3BKeller%2C+J%3BKesavapany%2C+S%3BAgarwal%2C+N%3BKuner%2C+R%3BPant%2C+H+C%3BIadarola%2C+M+J%3BKulkarni%2C+A+B&rft.aulast=Pareek&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expectation Selectively Enhances Discrimination of Fearful Faces T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358714; 4412079 JF - 36th Annual Meeting of the Society for Neuroscience AU - Doty, T J AU - Ingvar, M AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expectation+Selectively+Enhances+Discrimination+of+Fearful+Faces&rft.au=Doty%2C+T+J%3BIngvar%2C+M%3BUngerleider%2C+L+G&rft.aulast=Doty&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rostro-Caudal Topography of 3-, 2- And 1-Phase Respiratory Rhythms Revealed by Sequential Microsectioning of the Rat Brainstem in Situ T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358224; 4413353 JF - 36th Annual Meeting of the Society for Neuroscience AU - Smith, J C AU - Abdala, A P AU - Koizumi, H AU - Rybak, I A AU - Paton, J F R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Topography KW - Respiration KW - Rhythms KW - Brain stem KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rostro-Caudal+Topography+of+3-%2C+2-+And+1-Phase+Respiratory+Rhythms+Revealed+by+Sequential+Microsectioning+of+the+Rat+Brainstem+in+Situ&rft.au=Smith%2C+J+C%3BAbdala%2C+A+P%3BKoizumi%2C+H%3BRybak%2C+I+A%3BPaton%2C+J+F+R&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictability of Aversive Stimuli Modulates Activity in Amygdala and Ventral Striatum T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40357396; 4412200 JF - 36th Annual Meeting of the Society for Neuroscience AU - Alvarez, R P AU - Biggs, A AU - Grillon, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Amygdala KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40357396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Predictability+of+Aversive+Stimuli+Modulates+Activity+in+Amygdala+and+Ventral+Striatum&rft.au=Alvarez%2C+R+P%3BBiggs%2C+A%3BGrillon%2C+C&rft.aulast=Alvarez&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Focused and Divided Attention and Short-term Memory to Concurrent Auditory and Visual Information T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40357129; 4412073 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thai-Van, H AU - Smith, J F AU - Kim, J AU - Husain, F T AU - Kemeny, S AU - Braun, A R AU - Horwitz, B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Attention KW - Sensory integration KW - Short term memory KW - Visual stimuli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40357129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Focused+and+Divided+Attention+and+Short-term+Memory+to+Concurrent+Auditory+and+Visual+Information&rft.au=Thai-Van%2C+H%3BSmith%2C+J+F%3BKim%2C+J%3BHusain%2C+F+T%3BKemeny%2C+S%3BBraun%2C+A+R%3BHorwitz%2C+B&rft.aulast=Thai-Van&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparity-Detection: Psychophysically Measured Task Strategy is Reflected in Neural Responses in V2 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356537; 4418944 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Nienborg, H AU - Cumming, B G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Disparity-Detection%3A+Psychophysically+Measured+Task+Strategy+is+Reflected+in+Neural+Responses+in+V2&rft.au=Nienborg%2C+H%3BCumming%2C+B+G&rft.aulast=Nienborg&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Neuronal Activity in the Pre-Botzinger Complex by Medullary Raphe Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356418; 4413366 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ptak, K AU - Zhang, R AU - Milescu, L S AU - Richerson, G B AU - Smith, J C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neuromodulation KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Further+studies+on+aberrant+gene+expression+associated+with+arsenic-induced+malignant+transformation+in+rat+liver+TRL1215+cells&rft.au=Liu%2C+J%3BBenbrahim-Tallaa%2C+L%3BQian%2C+X%3BYu%2C+L%3BXie%2C+Y%3BBoos%2C+J%3BQu%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-11-01&rft.volume=216&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.06.006 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurophysiological Differences in Amygdala Activation in Response to Backwardly Masked Emotional Facial Stimuli in Major Depressive Disorder T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356324; 4418840 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ferguson, T A AU - Furey, M AU - Fromm, S AU - Iwamoto, H AU - Williams, J AU - Ohman, A AU - Drevets, W C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Amygdala KW - Emotions KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurophysiological+Differences+in+Amygdala+Activation+in+Response+to+Backwardly+Masked+Emotional+Facial+Stimuli+in+Major+Depressive+Disorder&rft.au=Ferguson%2C+T+A%3BFurey%2C+M%3BFromm%2C+S%3BIwamoto%2C+H%3BWilliams%2C+J%3BOhman%2C+A%3BDrevets%2C+W+C&rft.aulast=Ferguson&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automatic Construction and Stringent Validation of Path Models from Human fMRI Data T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355713; 4414146 JF - 36th Annual Meeting of the Society for Neuroscience AU - Stein, J L AU - Wiedholz, L M AU - Mattay, V AU - Weinberger, D R AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Models KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Automatic+Construction+and+Stringent+Validation+of+Path+Models+from+Human+fMRI+Data&rft.au=Stein%2C+J+L%3BWiedholz%2C+L+M%3BMattay%2C+V%3BWeinberger%2C+D+R%3BMeyer-Lindenberg%2C+A&rft.aulast=Stein&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral and Electrophysiological Analysis Reveals Innate Olfactory Information in a Moth T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355343; 4417578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ong, C R AU - Stopfer, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Olfaction KW - Electrophysiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+and+Electrophysiological+Analysis+Reveals+Innate+Olfactory+Information+in+a+Moth&rft.au=Ong%2C+C+R%3BStopfer%2C+M&rft.aulast=Ong&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of a Coding NRG1 Polymorphism (rs10503929) on Brain Structure in Normal Controls and Schizophrenia Subjects T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355023; 4414089 JF - 36th Annual Meeting of the Society for Neuroscience AU - Radulescu, E AU - Mattay, V S AU - Meyer-Lindenberg, A AU - Verchinski, B A AU - Honea, R AU - Das, S AU - Straub, R AU - Vakkalanka, R AU - Law, A J AU - Weinberger, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Schizophrenia KW - Mental disorders KW - Coding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Influence+of+a+Coding+NRG1+Polymorphism+%28rs10503929%29+on+Brain+Structure+in+Normal+Controls+and+Schizophrenia+Subjects&rft.au=Radulescu%2C+E%3BMattay%2C+V+S%3BMeyer-Lindenberg%2C+A%3BVerchinski%2C+B+A%3BHonea%2C+R%3BDas%2C+S%3BStraub%2C+R%3BVakkalanka%2C+R%3BLaw%2C+A+J%3BWeinberger%2C+D&rft.aulast=Radulescu&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Schizophrenics and Unaffected Siblings Exhibit Altered Amygdala-cingulate Functional Connectivity during the Perceptual Processing of Emotional Stimuli T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354809; 4412091 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rasetti, R AU - Mattay, V S AU - Wiedholz, L M AU - Marenco, S AU - Hariri, A AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Siblings KW - Schizophrenia KW - Emotions KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Schizophrenics+and+Unaffected+Siblings+Exhibit+Altered+Amygdala-cingulate+Functional+Connectivity+during+the+Perceptual+Processing+of+Emotional+Stimuli&rft.au=Rasetti%2C+R%3BMattay%2C+V+S%3BWiedholz%2C+L+M%3BMarenco%2C+S%3BHariri%2C+A%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Rasetti&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IQ Affects Prefrontal Activation during Working Memory in Patients with Schizophrenia and Healthy Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354767; 4412074 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brooke, J AU - Tan, H AU - Buckholtz, J AU - Mattay, V AU - Weickert, T AU - Weinberger, D AU - Callicott, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Intelligence KW - Schizophrenia KW - Mental disorders KW - Short term memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Transmissibility+and+mortality+impact+of+epidemic+and+pandemic+influenza%2C+with+emphasis+on+the+unusually+deadly+1951+epidemic&rft.au=Viboud%2C+Cecile%3BTam%2C+Theresa%3BFleming%2C+Douglas%3BHandel%2C+Andreas%3BMiller%2C+Mark+A%3BSimonsen%2C+Lone&rft.aulast=Viboud&rft.aufirst=Cecile&rft.date=2006-11-01&rft.volume=24&rft.issue=44&rft.spage=6701&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.067 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Amygdala Hyperactivity and Prefrontal Hypoactivity and Severity of Anxiety in Generalized Social Phobia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354499; 4418966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Peschardt, K AU - Morton, J AU - Smith, B AU - Geraci, M AU - Vythilingam, M AU - Finger, E AU - Drevets, W C AU - Pine, D S AU - Blair, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Anxiety KW - Hyperactivity KW - Amygdala KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Association+between+Amygdala+Hyperactivity+and+Prefrontal+Hypoactivity+and+Severity+of+Anxiety+in+Generalized+Social+Phobia&rft.au=Peschardt%2C+K%3BMorton%2C+J%3BSmith%2C+B%3BGeraci%2C+M%3BVythilingam%2C+M%3BFinger%2C+E%3BDrevets%2C+W+C%3BPine%2C+D+S%3BBlair%2C+J+R&rft.aulast=Peschardt&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Postnatal Development and Migration of Cerebellar Stellate and Basket Cells Examined in Mice Expressing Green Fluorescent Protein under the Glutamic Acid Decarboxylase 65 Promotor T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354143; 4418758 JF - 36th Annual Meeting of the Society for Neuroscience AU - Davis, M I AU - Lovinger, D M AU - Hassoun, A T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Glutamate decarboxylase KW - Cell migration KW - Green fluorescent protein KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Postnatal+Development+and+Migration+of+Cerebellar+Stellate+and+Basket+Cells+Examined+in+Mice+Expressing+Green+Fluorescent+Protein+under+the+Glutamic+Acid+Decarboxylase+65+Promotor&rft.au=Davis%2C+M+I%3BLovinger%2C+D+M%3BHassoun%2C+A+T&rft.aulast=Davis&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI Reveals the Impact of the CS-UCS Pairing Rate on Brain Activity during Pavlovian Fear Conditioning T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40353600; 4418960 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dunsmoor, J AU - Bandettini, P AU - Knight, D C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Functional magnetic resonance imaging KW - Fear conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=fMRI+Reveals+the+Impact+of+the+CS-UCS+Pairing+Rate+on+Brain+Activity+during+Pavlovian+Fear+Conditioning&rft.au=Dunsmoor%2C+J%3BBandettini%2C+P%3BKnight%2C+D+C&rft.aulast=Dunsmoor&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Anatomical Tract-Tracing Manganese-Enhanced MRI Uptake, Transport, and Detection T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40353379; 4418320 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wu, W C AU - Simmons, J AU - Chuang, K AU - Ortiz, M AU - Koretsky, A P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Vivo+Anatomical+Tract-Tracing+Manganese-Enhanced+MRI+Uptake%2C+Transport%2C+and+Detection&rft.au=Wu%2C+W+C%3BSimmons%2C+J%3BChuang%2C+K%3BOrtiz%2C+M%3BKoretsky%2C+A+P&rft.aulast=Wu&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Cerebellar mRNA in the C57Bl/WldS Mouse T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40352946; 4418719 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tsao, J W AU - Brug, M. Van Der AU - Chatterjee, M AU - Wishart, T M AU - Gillingwater, T H AU - Cookson, M R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - MRNA KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40352946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Changes+in+Cerebellar+mRNA+in+the+C57Bl%2FWldS+Mouse&rft.au=Tsao%2C+J+W%3BBrug%2C+M.+Van+Der%3BChatterjee%2C+M%3BWishart%2C+T+M%3BGillingwater%2C+T+H%3BCookson%2C+M+R&rft.aulast=Tsao&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Contrast Discrimination Learning in Early Visual Cortical Areas T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351891; 4412025 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mukai, I AU - Kim, D AU - Fukunaga, M AU - Japee, S AU - Marrett, S AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Discrimination KW - Discrimination learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Correlates+of+Contrast+Discrimination+Learning+in+Early+Visual+Cortical+Areas&rft.au=Mukai%2C+I%3BKim%2C+D%3BFukunaga%2C+M%3BJapee%2C+S%3BMarrett%2C+S%3BUngerleider%2C+L+G&rft.aulast=Mukai&rft.aufirst=I&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perception of Facial Expression Modulates Activity in Face-Responsive Regions of Amygdala and Visual Cortex: An fMRI Study in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351758; 4419365 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hadj-Bouziane, F AU - Knusten, T A AU - Bell, A H AU - Becker, J E AU - Doty, T J AU - Tootell, R B AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Perception KW - Amygdala KW - Functional magnetic resonance imaging KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Perception+of+Facial+Expression+Modulates+Activity+in+Face-Responsive+Regions+of+Amygdala+and+Visual+Cortex%3A+An+fMRI+Study+in+Monkeys&rft.au=Hadj-Bouziane%2C+F%3BKnusten%2C+T+A%3BBell%2C+A+H%3BBecker%2C+J+E%3BDoty%2C+T+J%3BTootell%2C+R+B%3BUngerleider%2C+L+G&rft.aulast=Hadj-Bouziane&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pro-Inflammatory Effects of Peripherally Administered Angiotensin Ii T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351490; 4413313 JF - 36th Annual Meeting of the Society for Neuroscience AU - Benicky, J AU - Larrayoz, I AU - Pavel, J AU - Sanchez-Lemus, E AU - Strbak, V AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Research+Priorities%3A+Tobacco+Control+Policies+to+Reduce+Tobacco+use+among+Low+SES+Women+and+Girls&rft.au=Levy%2C+Anna+T%3BMcLellan%2C+Deborah+L%3BFagan%2C+Pebbles%3BJones%2C+Wanda+K%3BKaufman%2C+Nancy+J&rft.aulast=Levy&rft.aufirst=Anna&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visibility-Related Modulation of Neural Responses in Visual Thalamic Nuclei T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350918; 4418370 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wilke, M AU - Mueller, K M AU - Leopold, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Thalamic nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Visibility-Related+Modulation+of+Neural+Responses+in+Visual+Thalamic+Nuclei&rft.au=Wilke%2C+M%3BMueller%2C+K+M%3BLeopold%2C+D+A&rft.aulast=Wilke&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BDNF Val66Met Polymorphism Modulates Hippocampal Engagement during a Simple Declarative Memory Task in the Elderly T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350817; 4417827 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mattay, V S AU - Murty, V AU - Sambataro, F AU - Das, S AU - Tan, H AU - Kolachana, B AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Elderly KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Geriatrics KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BDNF+Val66Met+Polymorphism+Modulates+Hippocampal+Engagement+during+a+Simple+Declarative+Memory+Task+in+the+Elderly&rft.au=Mattay%2C+V+S%3BMurty%2C+V%3BSambataro%2C+F%3BDas%2C+S%3BTan%2C+H%3BKolachana%2C+B%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Mattay&rft.aufirst=V&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Prefrontal Function in Medication-Free Parkinson's Disease during Working Memory T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349561; 4418074 JF - 36th Annual Meeting of the Society for Neuroscience AU - Padmanabhan, A AU - Wint, D P AU - Kohn, P D AU - Sarpal, D K AU - Furman, D J AU - McInerney - Leo, A AU - Meyer-Lindenberg, A AU - Lopez, G AU - Nussbaum, R AU - Berman, K F Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Short term memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+Prefrontal+Function+in+Medication-Free+Parkinson%27s+Disease+during+Working+Memory&rft.au=Padmanabhan%2C+A%3BWint%2C+D+P%3BKohn%2C+P+D%3BSarpal%2C+D+K%3BFurman%2C+D+J%3BMcInerney+-+Leo%2C+A%3BMeyer-Lindenberg%2C+A%3BLopez%2C+G%3BNussbaum%2C+R%3BBerman%2C+K+F&rft.aulast=Padmanabhan&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flexible Modulation of Agonist Efficacy At the Human A3 Adenosine Receptor by a Newly Synthesized Allosteric Enhancer Luf6000 and Its Analogs T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349300; 4417426 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gao, Z AU - Ye, K. AU - Mamedova, L K AU - Ijzerman, A P AU - Jacobson, K A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Allosteric properties KW - Adenosine receptors KW - Analogs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Flexible+Modulation+of+Agonist+Efficacy+At+the+Human+A3+Adenosine+Receptor+by+a+Newly+Synthesized+Allosteric+Enhancer+Luf6000+and+Its+Analogs&rft.au=Gao%2C+Z%3BYe%2C+K.%3BMamedova%2C+L+K%3BIjzerman%2C+A+P%3BJacobson%2C+K+A&rft.aulast=Gao&rft.aufirst=Z&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dopamine D2R Assessment during Cocaine Self-Administration Maintenance, Extinction, and Abstinence T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349101; 4418487 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Michaelides, M AU - Piyis, Y AU - Reiszel, C AU - Soria, G AU - Wang, G AU - Volkow, N D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Extinction KW - Drug self-administration KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dopamine+D2R+Assessment+during+Cocaine+Self-Administration+Maintenance%2C+Extinction%2C+and+Abstinence&rft.au=Thanos%2C+P+K%3BMichaelides%2C+M%3BPiyis%2C+Y%3BReiszel%2C+C%3BSoria%2C+G%3BWang%2C+G%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Cytokines Regulate the Production of Axon Growth-Inhibitory Molecules by Oligodendrocytes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40348042; 4414616 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wang, H AU - Mccann, T AU - Katagiri, Y AU - Laabs, T AU - Nie, H AU - Geller, H M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cytokines KW - Inflammation KW - Oligodendrocytes KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inflammatory+Cytokines+Regulate+the+Production+of+Axon+Growth-Inhibitory+Molecules+by+Oligodendrocytes&rft.au=Wang%2C+H%3BMccann%2C+T%3BKatagiri%2C+Y%3BLaabs%2C+T%3BNie%2C+H%3BGeller%2C+H+M&rft.aulast=Wang&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Avalanches In Vivo T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40348017; 4414577 JF - 36th Annual Meeting of the Society for Neuroscience AU - Petermann, T AU - Lebedev, M A AU - Nicolelis, M AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Avalanches KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=An+Analysis+of+the+Willingness+of+Cardiac+Patients+for+Referral+Treatment+from+a+Military+Medical+Center+to+Affiliated+Community+Clinics+in+Taiwan&rft.au=Ying%2C+Lai+Chao&rft.aulast=Ying&rft.aufirst=Lai&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Single Neuron Activity during Neuronal Avalanches T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347881; 4414585 JF - 36th Annual Meeting of the Society for Neuroscience AU - Falco, J J AU - Bellay, T E AU - Stewart, C V AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Avalanches KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Intracellular+Single+Neuron+Activity+during+Neuronal+Avalanches&rft.au=Falco%2C+J+J%3BBellay%2C+T+E%3BStewart%2C+C+V%3BPlenz%2C+D&rft.aulast=Falco&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GABA@@dA@Inhibition Maintains Spatial Homogeneity in the Propagation of Synchrony in Cortical Networks T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347846; 4414578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thiagarajan, T AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Oscillations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GABA%40%40dA%40Inhibition+Maintains+Spatial+Homogeneity+in+the+Propagation+of+Synchrony+in+Cortical+Networks&rft.au=Thiagarajan%2C+T%3BPlenz%2C+D&rft.aulast=Thiagarajan&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347472; 4415886 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhang, L AU - Sun, H AU - Peoples, R W AU - Ren, H AU - Hu, X. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Residues KW - Serotonin S3 receptors KW - Arginine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=An+Interaction+Involving+an+Arginine+Residue+in+the+Cytoplasmic+Domain+of+the+5-HT3A+Receptor+Contributes+to+Receptor+Desensitization&rft.au=Zhang%2C+L%3BSun%2C+H%3BPeoples%2C+R+W%3BRen%2C+H%3BHu%2C+X.&rft.aulast=Zhang&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - [@@u18@F]sp203 is a Novel Pet Radioligand for Brain mglur5 Receptors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347103; 4418305 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brown, A K AU - Simeon, F G AU - Liow, J AU - Zoghbi, S S AU - Gladding, R L AU - Pike, V W AU - Innis, R B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=%5B%40%40u18%40F%5Dsp203+is+a+Novel+Pet+Radioligand+for+Brain+mglur5+Receptors&rft.au=Brown%2C+A+K%3BSimeon%2C+F+G%3BLiow%2C+J%3BZoghbi%2C+S+S%3BGladding%2C+R+L%3BPike%2C+V+W%3BInnis%2C+R+B&rft.aulast=Brown&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Rat Alpha7 Nicotinic Acetylcholine Receptor Tryptophan77 to Channels Gating and Desensitization T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40346329; 4414318 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gay, E A AU - Yakel, J L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Acetylcholine receptors (nicotinic) KW - Channel gating KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Contribution+of+Rat+Alpha7+Nicotinic+Acetylcholine+Receptor+Tryptophan77+to+Channels+Gating+and+Desensitization&rft.au=Gay%2C+E+A%3BYakel%2C+J+L&rft.aulast=Gay&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trichostatin a Treatment after Disease Onset Increases Survival of Mice with Spinal Muscular Atrophy T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40346203; 4418090 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sumner, C J AU - Avila, A M AU - Burnett, B G AU - Taye, A A AU - Knight, M A AU - Di Prospero, N A AU - Fischbeck, K H Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Survival KW - Trichostatin A KW - Spinal muscular atrophy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Trichostatin+a+Treatment+after+Disease+Onset+Increases+Survival+of+Mice+with+Spinal+Muscular+Atrophy&rft.au=Sumner%2C+C+J%3BAvila%2C+A+M%3BBurnett%2C+B+G%3BTaye%2C+A+A%3BKnight%2C+M+A%3BDi+Prospero%2C+N+A%3BFischbeck%2C+K+H&rft.aulast=Sumner&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Orbitofrontal Cortex Lesions on Cocaine Self-Administration in Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345826; 4417019 JF - 36th Annual Meeting of the Society for Neuroscience AU - Grakalic, I AU - Panlilio, L V AU - Quiroz, C AU - Schindler, C W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Lesions KW - Rats KW - Drug self-administration KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Relationship+between+Self-Medication+with+Alcohol+and+Co-Morbid+Alcohol+use+Disorders+among+Individuals+with+Mood+and+Anxiety+Disorders&rft.au=Lakins%2C+Nekisha+E%3BYi%2C+Hsiao-ye%3BYahr%2C+Harold+T%3BFalk%2C+Daniel+E&rft.aulast=Lakins&rft.aufirst=Nekisha&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cocaine-Induced Neuronal Activation in Rat Brain Detected by Dynamic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345681; 4418495 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lu, H. AU - Xi, Z. AU - Gitajn, L AU - Rea, W AU - Scholl, C AU - Matochik, J A AU - Yang, Y AU - Stein, E A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cocaine-Induced+Neuronal+Activation+in+Rat+Brain+Detected+by+Dynamic+Manganese-Enhanced+Magnetic+Resonance+Imaging+%28MEMRI%29&rft.au=Lu%2C+H.%3BXi%2C+Z.%3BGitajn%2C+L%3BRea%2C+W%3BScholl%2C+C%3BMatochik%2C+J+A%3BYang%2C+Y%3BStein%2C+E+A&rft.aulast=Lu&rft.aufirst=H.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promoter Specific Alterations of BDNF mRNA in Frontal Cortex of Schizophrenics: Influence of Antidepressants T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345600; 4418474 JF - 36th Annual Meeting of the Society for Neuroscience AU - Weickert, C S AU - Deep-Soboslay, A AU - Cassano, H L AU - Hyde, T M AU - Kleinman, J E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antidepressants KW - Schizophrenia KW - Promoters KW - Mental disorders KW - Cortex (frontal) KW - MRNA KW - Brain-derived neurotrophic factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Promoter+Specific+Alterations+of+BDNF+mRNA+in+Frontal+Cortex+of+Schizophrenics%3A+Influence+of+Antidepressants&rft.au=Weickert%2C+C+S%3BDeep-Soboslay%2C+A%3BCassano%2C+H+L%3BHyde%2C+T+M%3BKleinman%2C+J+E&rft.aulast=Weickert&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overexpression of Human Catechol-O-Methyltransferase Transgene Impairs Cognitive but not Sensory Motor-Gating Function in Inducible Tissue-Specific Transgenic Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345510; 4416966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chen, J AU - Papaleo, F AU - Song, J AU - Liu, G AU - Stepp, B AU - Pickel, J M AU - Lipska, B K AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Transgenic mice KW - Cognitive ability KW - Catechol O-methyltransferase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Overexpression+of+Human+Catechol-O-Methyltransferase+Transgene+Impairs+Cognitive+but+not+Sensory+Motor-Gating+Function+in+Inducible+Tissue-Specific+Transgenic+Mice&rft.au=Chen%2C+J%3BPapaleo%2C+F%3BSong%2C+J%3BLiu%2C+G%3BStepp%2C+B%3BPickel%2C+J+M%3BLipska%2C+B+K%3BWeinberger%2C+D+R&rft.aulast=Chen&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Substrates Underlying Formation of an Internal Model for a Visuomotor Skill T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345449; 4415037 JF - 36th Annual Meeting of the Society for Neuroscience AU - Webster, B R AU - Celnik, P A AU - Xu, B. AU - Loubinoux, I AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Oculomotor behavior KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Substrates+Underlying+Formation+of+an+Internal+Model+for+a+Visuomotor+Skill&rft.au=Webster%2C+B+R%3BCelnik%2C+P+A%3BXu%2C+B.%3BLoubinoux%2C+I%3BCohen%2C+L+G&rft.aulast=Webster&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Habituation Properties of Cortical Auditory Responses in Schizophrenia Patients and Unaffected Siblings Revealed by Synthetic Aperture Magnetometry T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344981; 4415605 JF - 36th Annual Meeting of the Society for Neuroscience AU - Carver, F AU - Reynolds, C AU - Kirchberg, B AU - Mitchell-Francis, J AU - Holroyd, T AU - Egan, M AU - Weinberger, D AU - Coppola, R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Siblings KW - Schizophrenia KW - Mental disorders KW - Habituation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Habituation+Properties+of+Cortical+Auditory+Responses+in+Schizophrenia+Patients+and+Unaffected+Siblings+Revealed+by+Synthetic+Aperture+Magnetometry&rft.au=Carver%2C+F%3BReynolds%2C+C%3BKirchberg%2C+B%3BMitchell-Francis%2C+J%3BHolroyd%2C+T%3BEgan%2C+M%3BWeinberger%2C+D%3BCoppola%2C+R&rft.aulast=Carver&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Neural Processing of Facial Cues of Gonadal Steroid Status in Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344538; 4415408 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rainey, C AU - Draper, C K AU - Zink, C F AU - Chen, Q AU - Stein, J L AU - Kempf, L AU - Tong, Y AU - Swaddle, J P AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Sex KW - Sex hormones KW - Sex differences KW - Information processing KW - Steroid hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Gender+Differences+in+Neural+Processing+of+Facial+Cues+of+Gonadal+Steroid+Status+in+Humans&rft.au=Rainey%2C+C%3BDraper%2C+C+K%3BZink%2C+C+F%3BChen%2C+Q%3BStein%2C+J+L%3BKempf%2C+L%3BTong%2C+Y%3BSwaddle%2C+J+P%3BMeyer-Lindenberg%2C+A&rft.aulast=Rainey&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Ethanol Sensitivity of 5-HT3A Receptors by Interaction with the Light Chain of MAP1B T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344430; 4415890 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dong, L AU - Miko, A AU - Lovinger, D M AU - Zhang, L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Light chains KW - Microtubule-associated protein 1B KW - Serotonin S3 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+Ethanol+Sensitivity+of+5-HT3A+Receptors+by+Interaction+with+the+Light+Chain+of+MAP1B&rft.au=Dong%2C+L%3BMiko%2C+A%3BLovinger%2C+D+M%3BZhang%2C+L&rft.aulast=Dong&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - To Act or not to Act: A Systems-Level Brain Model of Inhibitory Control T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343912; 4415232 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kralik, J D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=To+Act+or+not+to+Act%3A+A+Systems-Level+Brain+Model+of+Inhibitory+Control&rft.au=Kralik%2C+J+D&rft.aulast=Kralik&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allelic Variation in COMT Effects during a Processing Speed Task in Healthy Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343409; 4415217 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Callicott, J H AU - Sust, S AU - Tan, H AU - Zoltick, B J AU - Mattay, V S AU - Rypma, B AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Allelic+Variation+in+COMT+Effects+during+a+Processing+Speed+Task+in+Healthy+Volunteers&rft.au=Callicott%2C+J+H%3BSust%2C+S%3BTan%2C+H%3BZoltick%2C+B+J%3BMattay%2C+V+S%3BRypma%2C+B%3BWeinberger%2C+D+R&rft.aulast=Callicott&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison between Glycinergic and GABAergic Nonreciprocal Feedback Inhibition of Rod Bipolar Cells in Rat Retina T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343293; 4414500 JF - 36th Annual Meeting of the Society for Neuroscience AU - Diamond, J S AU - Chavez, A E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Retina KW - Feedback inhibition KW - Bipolar cells KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Comparison+between+Glycinergic+and+GABAergic+Nonreciprocal+Feedback+Inhibition+of+Rod+Bipolar+Cells+in+Rat+Retina&rft.au=Diamond%2C+J+S%3BChavez%2C+A+E&rft.aulast=Diamond&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Cortical Activity to Changes in Firing Rate and Pattern of Subthalamic Neurons in a Rodent Model of Parkinson's Disease T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342880; 4409659 JF - 36th Annual Meeting of the Society for Neuroscience AU - Parr-Brownlie, L C AU - Poloskey, S L AU - Bergstrom, D A AU - Gonzales, K K AU - Walters, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Animal models KW - Firing rate KW - Cortex KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Contribution+of+Cortical+Activity+to+Changes+in+Firing+Rate+and+Pattern+of+Subthalamic+Neurons+in+a+Rodent+Model+of+Parkinson%27s+Disease&rft.au=Parr-Brownlie%2C+L+C%3BPoloskey%2C+S+L%3BBergstrom%2C+D+A%3BGonzales%2C+K+K%3BWalters%2C+J+R&rft.aulast=Parr-Brownlie&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Locust Olfactory Responses to Trains of Odor Pulses Show Multiple Timing-Dependent Forms of Plasticity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342850; 4414627 JF - 36th Annual Meeting of the Society for Neuroscience AU - Joseph, J AU - Brown, S L AU - Stopfer, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Odors KW - Plasticity KW - Olfaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Locust+Olfactory+Responses+to+Trains+of+Odor+Pulses+Show+Multiple+Timing-Dependent+Forms+of+Plasticity&rft.au=Joseph%2C+J%3BBrown%2C+S+L%3BStopfer%2C+M&rft.aulast=Joseph&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Expression of Ca@@u2+@-Permeable AMPARs Underlies Depolarization-Induced LTD (DiLTD) of Mossy Fiber T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342702; 4412833 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ho, T. AU - Pelkey, K A AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - Mcbain, C J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Long-term depression KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Developmental stages KW - Mossy fibers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Expression+of+Ca%40%40u2%2B%40-Permeable+AMPARs+Underlies+Depolarization-Induced+LTD+%28DiLTD%29+of+Mossy+Fiber&rft.au=Ho%2C+T.%3BPelkey%2C+K+A%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcbain%2C+C+J&rft.aulast=Ho&rft.aufirst=T.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Amygdala Ameliorates Chronic Stress-Induced Cognitive Deficits and Associated Reduction in the Levels of Neurotransmitters in the Hippocampus T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342526; 4416869 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rao, B AU - Deepti, N AU - Chattarji, S AU - Raju, T R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neurotransmitters KW - Amygdala KW - Hippocampus KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inactivation+of+Amygdala+Ameliorates+Chronic+Stress-Induced+Cognitive+Deficits+and+Associated+Reduction+in+the+Levels+of+Neurotransmitters+in+the+Hippocampus&rft.au=Rao%2C+B%3BDeepti%2C+N%3BChattarji%2C+S%3BRaju%2C+T+R&rft.aulast=Rao&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the Context-Sensitivity of Ventral Temporal Category Representations using High-Resolution fMRI T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342271; 4410060 JF - 36th Annual Meeting of the Society for Neuroscience AU - Simmons, W K AU - Matlis, S AU - Bellgowan, P S AU - Bodurka, J AU - Barsalou, L W AU - Martin, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+the+Context-Sensitivity+of+Ventral+Temporal+Category+Representations+using+High-Resolution+fMRI&rft.au=Simmons%2C+W+K%3BMatlis%2C+S%3BBellgowan%2C+P+S%3BBodurka%2C+J%3BBarsalou%2C+L+W%3BMartin%2C+A&rft.aulast=Simmons&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Kisspeptin and GPR54 in Hypothalamic GnRH Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341988; 4409712 JF - 36th Annual Meeting of the Society for Neuroscience AU - Quaynor, S AU - Hu, L. AU - Gustofson, G L AU - Defagot, M C AU - Krsmanovic, L Z AU - Catt, K J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Kiss1 protein KW - Hypothalamus KW - Neurons KW - Gonadotropin-releasing hormone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+of+Kisspeptin+and+GPR54+in+Hypothalamic+GnRH+Neurons&rft.au=Quaynor%2C+S%3BHu%2C+L.%3BGustofson%2C+G+L%3BDefagot%2C+M+C%3BKrsmanovic%2C+L+Z%3BCatt%2C+K+J&rft.aulast=Quaynor&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ipsilateral Activation of Motor and Premotor Areas during an Isometric Wrist Force Task in Healthy Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341950; 4409700 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sehm, B S AU - Perez, M A AU - Xu, B. AU - Hidler, J AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Isometric KW - Wrist KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ipsilateral+Activation+of+Motor+and+Premotor+Areas+during+an+Isometric+Wrist+Force+Task+in+Healthy+Humans&rft.au=Sehm%2C+B+S%3BPerez%2C+M+A%3BXu%2C+B.%3BHidler%2C+J%3BCohen%2C+L+G&rft.aulast=Sehm&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trait Variation in Attachment Predicts Ventral Striatal Activation and Prefrontal-Striatal Coupling during Exposure to Aversive Social Cues T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341528; 4415401 JF - 36th Annual Meeting of the Society for Neuroscience AU - Buckholtz, J W AU - Callicott, J H AU - Hariri, A R AU - Goldberg, T E AU - Genderson, M AU - Mattay, V S AU - Weinberger, D R AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Trait+Variation+in+Attachment+Predicts+Ventral+Striatal+Activation+and+Prefrontal-Striatal+Coupling+during+Exposure+to+Aversive+Social+Cues&rft.au=Buckholtz%2C+J+W%3BCallicott%2C+J+H%3BHariri%2C+A+R%3BGoldberg%2C+T+E%3BGenderson%2C+M%3BMattay%2C+V+S%3BWeinberger%2C+D+R%3BMeyer-Lindenberg%2C+A&rft.aulast=Buckholtz&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thought Disorder, Verbal Fluency, and Neural Activity in Schizophrenia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341359; 4415609 JF - 36th Annual Meeting of the Society for Neuroscience AU - Roe, K V AU - Sarpal, D AU - Chang, W AU - Bonner-Jackson, A AU - Goldberg, T S AU - Meyer-Lindenberg, A AU - Weinberger, D R AU - Berman, K F Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Schizophrenia KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Thought+Disorder%2C+Verbal+Fluency%2C+and+Neural+Activity+in+Schizophrenia&rft.au=Roe%2C+K+V%3BSarpal%2C+D%3BChang%2C+W%3BBonner-Jackson%2C+A%3BGoldberg%2C+T+S%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R%3BBerman%2C+K+F&rft.aulast=Roe&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BLOC-1 Complex Components Dysbindin (Dtnbp1) and MUTED Modulate Dopamine D2 Receptor Endocytosis in Human Neuroblastoma Cells and Lymphoblasts T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341318; 4415618 JF - 36th Annual Meeting of the Society for Neuroscience AU - Iizuka, Y AU - Sei, Y AU - Li, Z. AU - Weinberger, D R AU - Straub, R E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Endocytosis KW - Neuroblastoma cells KW - Lymphoblasts KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BLOC-1+Complex+Components+Dysbindin+%28Dtnbp1%29+and+MUTED+Modulate+Dopamine+D2+Receptor+Endocytosis+in+Human+Neuroblastoma+Cells+and+Lymphoblasts&rft.au=Iizuka%2C+Y%3BSei%2C+Y%3BLi%2C+Z.%3BWeinberger%2C+D+R%3BStraub%2C+R+E&rft.aulast=Iizuka&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Representation of Social Hierarchy in Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341172; 4415390 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zink, C F AU - Tong, Y AU - Stein, J L AU - Rainey, C A AU - Draper, C K AU - Kempf, L AU - Chen, Q AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Social hierarchy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Representation+of+Social+Hierarchy+in+Humans&rft.au=Zink%2C+C+F%3BTong%2C+Y%3BStein%2C+J+L%3BRainey%2C+C+A%3BDraper%2C+C+K%3BKempf%2C+L%3BChen%2C+Q%3BMeyer-Lindenberg%2C+A&rft.aulast=Zink&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype Effects on Serotonin Transporter Availability Measured with PET and the Radioligand DASB T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40340922; 4415224 JF - 36th Annual Meeting of the Society for Neuroscience AU - Heinz, A AU - Wrase, J AU - Smolka, M AU - Gunter, S AU - Goldman, D AU - Hu, X. AU - Reimold, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Genotypes KW - Serotonin transporter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genotype+Effects+on+Serotonin+Transporter+Availability+Measured+with+PET+and+the+Radioligand+DASB&rft.au=Heinz%2C+A%3BWrase%2C+J%3BSmolka%2C+M%3BGunter%2C+S%3BGoldman%2C+D%3BHu%2C+X.%3BReimold%2C+M&rft.aulast=Heinz&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in Dopamine Regulating Genes Modulate Cingulate Activity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40340519; 4415209 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wabnitz, A M AU - Mattay, V S AU - Blasi, G AU - Weickert, T AU - Kolachana, B AU - Das, S AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Gene polymorphism KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Polymorphisms+in+Dopamine+Regulating+Genes+Modulate+Cingulate+Activity&rft.au=Wabnitz%2C+A+M%3BMattay%2C+V+S%3BBlasi%2C+G%3BWeickert%2C+T%3BKolachana%2C+B%3BDas%2C+S%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Wabnitz&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - @@u125@I a-Bungarotoxin Binding Sites within the Human Dorsolateral Prefrontal Cortex (DLPFC) T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339940; 4415617 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mathew, S V AU - Davila-Garcia, M I AU - Herman, M M AU - Kleinman, J E AU - Hyde, T M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Bungarotoxin KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=%40%40u125%40I+a-Bungarotoxin+Binding+Sites+within+the+Human+Dorsolateral+Prefrontal+Cortex+%28DLPFC%29&rft.au=Mathew%2C+S+V%3BDavila-Garcia%2C+M+I%3BHerman%2C+M+M%3BKleinman%2C+J+E%3BHyde%2C+T+M&rft.aulast=Mathew&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Passive Avoidance Extinction: A n fMRI Investigation of the Extinction of Instrumentally Learned Avoidance and Approach T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339671; 4407131 JF - 36th Annual Meeting of the Society for Neuroscience AU - Finger, E C AU - Mitchell, D G AU - Jones, M AU - Blair, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Extinction KW - Functional magnetic resonance imaging KW - Avoidance reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Passive+Avoidance+Extinction%3A+A+n+fMRI+Investigation+of+the+Extinction+of+Instrumentally+Learned+Avoidance+and+Approach&rft.au=Finger%2C+E+C%3BMitchell%2C+D+G%3BJones%2C+M%3BBlair%2C+J+R&rft.aulast=Finger&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Responses in Monkey Area V4 and Pulvinar after Visual Shape Adaptation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339665; 4412975 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mueller, K AU - Wilke, M AU - Leopold, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Adaptations KW - Pulvinar KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Responses+in+Monkey+Area+V4+and+Pulvinar+after+Visual+Shape+Adaptation&rft.au=Mueller%2C+K%3BWilke%2C+M%3BLeopold%2C+D+A&rft.aulast=Mueller&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Computer Interface Control of a Paralyzed Hand Utilizing Activity from Ipsilesional Sensorimotor Areas after Severe Chronic Subcortical Stroke T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339152; 4409943 JF - 36th Annual Meeting of the Society for Neuroscience AU - Buch, E R AU - Weber, C AU - Birbaumer, N AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Sensorimotor system KW - Stroke KW - Hand KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brain+Computer+Interface+Control+of+a+Paralyzed+Hand+Utilizing+Activity+from+Ipsilesional+Sensorimotor+Areas+after+Severe+Chronic+Subcortical+Stroke&rft.au=Buch%2C+E+R%3BWeber%2C+C%3BBirbaumer%2C+N%3BCohen%2C+L+G&rft.aulast=Buch&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Juvenile Social Interactions and Pup Ultrasonic Vocalizations in BTBR T@@u+@ tf/J Versus C57Bl/6J Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338792; 4408695 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mcfarlane, H G AU - Scattoni, M L AU - Crawley, J N Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Volatile organic compounds KW - Ultrasonics KW - Mice KW - Social interactions KW - Vocalization behaviour KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Juvenile+Social+Interactions+and+Pup+Ultrasonic+Vocalizations+in+BTBR+T%40%40u%2B%40+tf%2FJ+Versus+C57Bl%2F6J+Mice&rft.au=Mcfarlane%2C+H+G%3BScattoni%2C+M+L%3BCrawley%2C+J+N&rft.aulast=Mcfarlane&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sustained Angiotensin II AT1 Receptor Antagonism Attenuates the Hormonal Response to Peripheral Administration of Lipopolysaccharide to Normotensive Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338711; 4411871 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sanchez-Lemus, E AU - Moughamian, A J AU - Nishioku, T AU - Larrayoz, I M AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antagonism KW - Rats KW - Lipopolysaccharides KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sustained+Angiotensin+II+AT1+Receptor+Antagonism+Attenuates+the+Hormonal+Response+to+Peripheral+Administration+of+Lipopolysaccharide+to+Normotensive+Rats&rft.au=Sanchez-Lemus%2C+E%3BMoughamian%2C+A+J%3BNishioku%2C+T%3BLarrayoz%2C+I+M%3BSaavedra%2C+J+M&rft.aulast=Sanchez-Lemus&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Re-Grouping of Visual Categories with and without Motor Association in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338653; 4407990 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lerchner, A AU - Minamimoto, T AU - Soucy, D P AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Motors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamic+Re-Grouping+of+Visual+Categories+with+and+without+Motor+Association+in+Monkeys&rft.au=Lerchner%2C+A%3BMinamimoto%2C+T%3BSoucy%2C+D+P%3BRichmond%2C+B+J&rft.aulast=Lerchner&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Acute Immobilization Stress in Adult Male Fragile X Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338601; 4409019 JF - 36th Annual Meeting of the Society for Neuroscience AU - Qin, M AU - Xia, Z AU - Smith, C B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Stress KW - Mice KW - Immobilization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Acute+Immobilization+Stress+in+Adult+Male+Fragile+X+Mice&rft.au=Qin%2C+M%3BXia%2C+Z%3BSmith%2C+C+B&rft.aulast=Qin&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Dopamine in Habit Formation Versus Cognitive Memory T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338578; 4407989 JF - 36th Annual Meeting of the Society for Neuroscience AU - Turchi, J N AU - Castillo, O AU - Saunders, R C AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cognitive ability KW - Memory KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Role+of+Dopamine+in+Habit+Formation+Versus+Cognitive+Memory&rft.au=Turchi%2C+J+N%3BCastillo%2C+O%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Turchi&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profile of Disc1 in Human Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338547; 4408913 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lipska, B K AU - Halim, N AU - Mitkus, S AU - Hyde, T M AU - Weinberger, D R AU - Kleinman, J E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - DISC1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+Profile+of+Disc1+in+Human+Brain&rft.au=Lipska%2C+B+K%3BHalim%2C+N%3BMitkus%2C+S%3BHyde%2C+T+M%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Lipska&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temporal Encoding of Auditory Objects in Rostral Superior Temporal Cortex of Behaving Macaques T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338214; 4411591 JF - 36th Annual Meeting of the Society for Neuroscience AU - Scott, B H AU - Yin, P AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cortex (temporal) KW - Coding KW - Cortex (auditory) KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Temporal+Encoding+of+Auditory+Objects+in+Rostral+Superior+Temporal+Cortex+of+Behaving+Macaques&rft.au=Scott%2C+B+H%3BYin%2C+P%3BMishkin%2C+M&rft.aulast=Scott&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Developmental Reductions in Subventricular Zone erbB1 and erbB4 Receptor mRNA Expression in the Human Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338058; 4408915 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chong, V Z AU - Webster, M J AU - Weickert, C Shannon Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Gene expression KW - ErbB-2 protein KW - ErbB-1 protein KW - Subventricular zone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Specific+Developmental+Reductions+in+Subventricular+Zone+erbB1+and+erbB4+Receptor+mRNA+Expression+in+the+Human+Brain&rft.au=Chong%2C+V+Z%3BWebster%2C+M+J%3BWeickert%2C+C+Shannon&rft.aulast=Chong&rft.aufirst=V&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Lentiviral-Generated RNA Interference to Investigate the Role of different G-Protein Subunit Isoforms in Voltage-Dependent Inhibition of N-Type Voltage-Gated Ca@@d2+@ Channels in Rat Superior Cervical Ganglia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337881; 4407612 JF - 36th Annual Meeting of the Society for Neuroscience AU - Williams, D J AU - Puhl, H L AU - Ikeda, S R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - RNA-mediated interference KW - Ganglia KW - Guanine nucleotide-binding protein KW - Calcium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Using+Lentiviral-Generated+RNA+Interference+to+Investigate+the+Role+of+different+G-Protein+Subunit+Isoforms+in+Voltage-Dependent+Inhibition+of+N-Type+Voltage-Gated+Ca%40%40d2%2B%40+Channels+in+Rat+Superior+Cervical+Ganglia&rft.au=Williams%2C+D+J%3BPuhl%2C+H+L%3BIkeda%2C+S+R&rft.aulast=Williams&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Learning of Visual Categories without Instruction in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337879; 4407994 JF - 36th Annual Meeting of the Society for Neuroscience AU - Soucy, D P AU - Richmond, B J AU - Minamimoto, T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Visual discrimination learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rapid+Learning+of+Visual+Categories+without+Instruction+in+Monkeys&rft.au=Soucy%2C+D+P%3BRichmond%2C+B+J%3BMinamimoto%2C+T&rft.aulast=Soucy&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroprotective Effects of Lamotrigine in Rat Brain Neurons: Synergy with Mood Stabilizers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337518; 4410692 JF - 36th Annual Meeting of the Society for Neuroscience AU - Leng, Y AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Neuroprotection KW - Mood KW - Lamotrigine KW - Neurons KW - Stabilizers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuroprotective+Effects+of+Lamotrigine+in+Rat+Brain+Neurons%3A+Synergy+with+Mood+Stabilizers&rft.au=Leng%2C+Y%3BChuang%2C+D&rft.aulast=Leng&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysregulation of Granule Cell Migration by Ethanol Examined using Transgenic Mice Expressing Green Fluorescent Protein under the GAP43 Promotor T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337494; 4408966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hassoun, A T AU - Lovinger, D M AU - Davis, M I Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Mice KW - Granule cells KW - Cell migration KW - Green fluorescent protein KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dysregulation+of+Granule+Cell+Migration+by+Ethanol+Examined+using+Transgenic+Mice+Expressing+Green+Fluorescent+Protein+under+the+GAP43+Promotor&rft.au=Hassoun%2C+A+T%3BLovinger%2C+D+M%3BDavis%2C+M+I&rft.aulast=Hassoun&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frequency-Dependent and D2 Receptor-Mediated Inhibition of Glutamate Release by Retrograde Endocannabinoid Signaling T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337140; 4406661 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yin, H H AU - Lovinger, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Glutamic acid KW - Cannabinoids KW - Frequency dependence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Frequency-Dependent+and+D2+Receptor-Mediated+Inhibition+of+Glutamate+Release+by+Retrograde+Endocannabinoid+Signaling&rft.au=Yin%2C+H+H%3BLovinger%2C+D&rft.aulast=Yin&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuregulin-1-Induced, Integrin-Mediated Cell Adhesion is Impaired in Schizophrenia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336993; 4408911 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kanakry, C G AU - Li, Z. AU - Sei, Y AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Schizophrenia KW - Cell adhesion KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuregulin-1-Induced%2C+Integrin-Mediated+Cell+Adhesion+is+Impaired+in+Schizophrenia&rft.au=Kanakry%2C+C+G%3BLi%2C+Z.%3BSei%2C+Y%3BWeinberger%2C+D+R&rft.aulast=Kanakry&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antidepressant-Like Actions of Fluoxetine Treatment in GALR2 Null Mutant Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336980; 4407154 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bailey, K R AU - Hohmann, J G AU - Zeng, H AU - Crawley, J N Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antidepressants KW - Mice KW - Mutants KW - Fluoxetine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Antidepressant-Like+Actions+of+Fluoxetine+Treatment+in+GALR2+Null+Mutant+Mice&rft.au=Bailey%2C+K+R%3BHohmann%2C+J+G%3BZeng%2C+H%3BCrawley%2C+J+N&rft.aulast=Bailey&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Localizations and Functions of STAM Adaptor Molecules T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336847; 4407397 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rismanchi, N AU - Blackstone, C D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Cell death KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Localizations+and+Functions+of+STAM+Adaptor+Molecules&rft.au=Rismanchi%2C+N%3BBlackstone%2C+C+D&rft.aulast=Rismanchi&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risks, Rewards, and the Alcoholic Brain: An fMRI Investigation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336564; 4413589 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bjork, J M AU - Hommer, D W AU - Murthy, S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Reinforcement KW - Alcoholics KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Risks%2C+Rewards%2C+and+the+Alcoholic+Brain%3A+An+fMRI+Investigation&rft.au=Bjork%2C+J+M%3BHommer%2C+D+W%3BMurthy%2C+S&rft.aulast=Bjork&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Various Presynaptic Proteins are Transported in Heterogeneous Packets, Multivesicle T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336523; 4411504 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tao-Cheng, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Various+Presynaptic+Proteins+are+Transported+in+Heterogeneous+Packets%2C+Multivesicle&rft.au=Tao-Cheng%2C+J&rft.aulast=Tao-Cheng&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Fret Efficiency and Relative Abundance of Donor and Acceptor Molecules in Living Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336342; 4410865 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chen, H AU - Puhl III, H L AU - Koushik, S V AU - Vogel, S S AU - Ikeda, S R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Abundance KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measurement+of+Fret+Efficiency+and+Relative+Abundance+of+Donor+and+Acceptor+Molecules+in+Living+Cells&rft.au=Chen%2C+H%3BPuhl+III%2C+H+L%3BKoushik%2C+S+V%3BVogel%2C+S+S%3BIkeda%2C+S+R&rft.aulast=Chen&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Voluntary Contraction of Lower-Limb Muscles on Motor-Evoked Responses in the Contralateral Resting Leg T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335512; 4409926 JF - 36th Annual Meeting of the Society for Neuroscience AU - Perez, M A AU - Nielsen, J B AU - Drucaroff, B AU - Hidler, J AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Muscle contraction KW - Leg KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Voluntary+Contraction+of+Lower-Limb+Muscles+on+Motor-Evoked+Responses+in+the+Contralateral+Resting+Leg&rft.au=Perez%2C+M+A%3BNielsen%2C+J+B%3BDrucaroff%2C+B%3BHidler%2C+J%3BCohen%2C+L+G&rft.aulast=Perez&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nongenotoxic Transcriptional Activation of Tumor Suppressor P53 by NGF-Mediated Neuronal Differentiation is Revealed Via Genomic Interrogation of P53 DNA Binding T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335502; 4408755 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brynczka, C AU - Merrick, B A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - P53 protein KW - Transcription activation KW - Differentiation KW - Genomics KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Nongenotoxic+Transcriptional+Activation+of+Tumor+Suppressor+P53+by+NGF-Mediated+Neuronal+Differentiation+is+Revealed+Via+Genomic+Interrogation+of+P53+DNA+Binding&rft.au=Brynczka%2C+C%3BMerrick%2C+B+A&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAP6 in Schizophrenia: Genetic Association and mRNA Expression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335339; 4408912 JF - 36th Annual Meeting of the Society for Neuroscience AU - Saylor, E M AU - Joseph, L T AU - Mitkus, S N AU - Hyde, T M AU - Nicodemus, K K AU - Callicott, J H AU - Straub, R E AU - Vakkalanka, R K AU - Kleinman, J E AU - Weinberger, D R AU - Lipska, B K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Gene expression KW - Schizophrenia KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAP6+in+Schizophrenia%3A+Genetic+Association+and+mRNA+Expression&rft.au=Saylor%2C+E+M%3BJoseph%2C+L+T%3BMitkus%2C+S+N%3BHyde%2C+T+M%3BNicodemus%2C+K+K%3BCallicott%2C+J+H%3BStraub%2C+R+E%3BVakkalanka%2C+R+K%3BKleinman%2C+J+E%3BWeinberger%2C+D+R%3BLipska%2C+B+K&rft.aulast=Saylor&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol Modulation of D@@d1@ Receptor Signaling Appears to be Mediated by Protein Kinase C in an Isoform-Specific Fashion T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335188; 4407578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rex, E B AU - Rankin, M L AU - Cabrera, D M AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Signal transduction KW - Protein kinase C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ethanol+Modulation+of+D%40%40d1%40+Receptor+Signaling+Appears+to+be+Mediated+by+Protein+Kinase+C+in+an+Isoform-Specific+Fashion&rft.au=Rex%2C+E+B%3BRankin%2C+M+L%3BCabrera%2C+D+M%3BSibley%2C+D+R&rft.aulast=Rex&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fos-like Activity in the Brains of Vocalizing Common Marmoset Infants T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335183; 4412230 JF - 36th Annual Meeting of the Society for Neuroscience AU - Newman, J D AU - Aronoff, E C AU - Rakhovskaya, M V AU - Bernhards, D E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Volatile organic compounds KW - Infants KW - Brain KW - Callithrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Fos-like+Activity+in+the+Brains+of+Vocalizing+Common+Marmoset+Infants&rft.au=Newman%2C+J+D%3BAronoff%2C+E+C%3BRakhovskaya%2C+M+V%3BBernhards%2C+D+E&rft.aulast=Newman&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacological Characterization of the Interactions of Methylnorapomorphine (MNPA) with D@@d2@ Dopamine Receptors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335139; 4407576 JF - 36th Annual Meeting of the Society for Neuroscience AU - Skinbjerg, M AU - Namkung, Y AU - Halldin, C AU - Innis, R B AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Pharmacological+Characterization+of+the+Interactions+of+Methylnorapomorphine+%28MNPA%29+with+D%40%40d2%40+Dopamine+Receptors&rft.au=Skinbjerg%2C+M%3BNamkung%2C+Y%3BHalldin%2C+C%3BInnis%2C+R+B%3BSibley%2C+D+R&rft.aulast=Skinbjerg&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin-25 Regulates D@@d1@ and D@@d2@ Dopamine Receptor Expression and Signaling T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334929; 4407575 JF - 36th Annual Meeting of the Society for Neuroscience AU - Free, R AU - Hazelwood, L A AU - Cabrera, D M AU - Spalding, H N AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sorting+Nexin-25+Regulates+D%40%40d1%40+and+D%40%40d2%40+Dopamine+Receptor+Expression+and+Signaling&rft.au=Free%2C+R%3BHazelwood%2C+L+A%3BCabrera%2C+D+M%3BSpalding%2C+H+N%3BSibley%2C+D+R&rft.aulast=Free&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of PKA, PKC and CaMKII Phosphorylation Sites in the C-Terminus of the GluR6 Subunit T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334912; 4412756 JF - 36th Annual Meeting of the Society for Neuroscience AU - Nishimura, Y AU - Kelver, D AU - Braud, S AU - Isaac, J T AU - Roche, K W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Protein kinase A KW - C-Terminus KW - Phosphorylation KW - Protein kinase C KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+PKA%2C+PKC+and+CaMKII+Phosphorylation+Sites+in+the+C-Terminus+of+the+GluR6+Subunit&rft.au=Nishimura%2C+Y%3BKelver%2C+D%3BBraud%2C+S%3BIsaac%2C+J+T%3BRoche%2C+K+W&rft.aulast=Nishimura&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II AT1 Receptor Blockade Reduces the Innate Inflammatory Response to Lipopolysaccharide in Rat Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334828; 4410720 JF - 36th Annual Meeting of the Society for Neuroscience AU - Larrayoz, I M AU - Nishioku, T AU - Benicky, J AU - Murakami, Y AU - De Nicola, A F AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Lipopolysaccharides KW - Inflammation KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+AT1+Receptor+Blockade+Reduces+the+Innate+Inflammatory+Response+to+Lipopolysaccharide+in+Rat+Brain&rft.au=Larrayoz%2C+I+M%3BNishioku%2C+T%3BBenicky%2C+J%3BMurakami%2C+Y%3BDe+Nicola%2C+A+F%3BSaavedra%2C+J+M&rft.aulast=Larrayoz&rft.aufirst=I&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Presynaptic Glutamate Release in the Cortical Input to the Lateral Amygdala Coincides with the Deficit of Fear Learning in Rap1A/Rap1B Double Knock-Out Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334819; 4410351 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pan, B AU - Vautier, F AU - Ito, W AU - Morozov, A Y Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Glutamic acid KW - Learning KW - Fear KW - Amygdala KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Enhanced+Presynaptic+Glutamate+Release+in+the+Cortical+Input+to+the+Lateral+Amygdala+Coincides+with+the+Deficit+of+Fear+Learning+in+Rap1A%2FRap1B+Double+Knock-Out+Mice&rft.au=Pan%2C+B%3BVautier%2C+F%3BIto%2C+W%3BMorozov%2C+A+Y&rft.aulast=Pan&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free Fatty Acids Alter the Function of Ligand-Gated Ion Channels Expressed in Xenopus Oocytes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334657; 4407511 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kloda, J H AU - Mitchell, D C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Fatty acids KW - Ion channels (ligand-gated) KW - Oocytes KW - Amphibiotic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Free+Fatty+Acids+Alter+the+Function+of+Ligand-Gated+Ion+Channels+Expressed+in+Xenopus+Oocytes&rft.au=Kloda%2C+J+H%3BMitchell%2C+D+C&rft.aulast=Kloda&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Emotional Processing of High-Arousal Positive and Negative Images in Alcohol-Dependent Patients T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334627; 4408945 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gilman, J M AU - Salloum, J B AU - Hommer, D W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Emotional+Processing+of+High-Arousal+Positive+and+Negative+Images+in+Alcohol-Dependent+Patients&rft.au=Gilman%2C+J+M%3BSalloum%2C+J+B%3BHommer%2C+D+W&rft.aulast=Gilman&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interhemispheric Inhibition in Distal and Proximal ARM Representations in the Primary Motor Cortex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334554; 4409911 JF - 36th Annual Meeting of the Society for Neuroscience AU - Harris-Love, M L AU - Chen, R AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cerebral hemispheres KW - Cortex (motor) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interhemispheric+Inhibition+in+Distal+and+Proximal+ARM+Representations+in+the+Primary+Motor+Cortex&rft.au=Harris-Love%2C+M+L%3BChen%2C+R%3BCohen%2C+L+G&rft.aulast=Harris-Love&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association Studies of Human Metabotropic Glutamate Receptors in Drug Addiction T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334501; 4412563 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhang, P AU - Liu, Q AU - Drgon, T AU - Walther, D AU - Johnson, C AU - Uhl, G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Drug addiction KW - Glutamic acid receptors (metabotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Association+Studies+of+Human+Metabotropic+Glutamate+Receptors+in+Drug+Addiction&rft.au=Zhang%2C+P%3BLiu%2C+Q%3BDrgon%2C+T%3BWalther%2C+D%3BJohnson%2C+C%3BUhl%2C+G&rft.aulast=Zhang&rft.aufirst=P&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction of Distractibility and Task Difficulty in ADHD T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334458; 4410264 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wagman, M R AU - Friedman-Hill, S R AU - Speer, A M AU - Pine, D S AU - Leibenluft, E AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Attention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Interaction+of+Distractibility+and+Task+Difficulty+in+ADHD&rft.au=Wagman%2C+M+R%3BFriedman-Hill%2C+S+R%3BSpeer%2C+A+M%3BPine%2C+D+S%3BLeibenluft%2C+E%3BUngerleider%2C+L+G&rft.aulast=Wagman&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Representation of Auditory Stimulus-Quality in the Monkey's Rostral Supratemporal Plane T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334439; 4411594 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kikuchi, Y AU - Horwitz, B AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cortex (auditory) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Representation+of+Auditory+Stimulus-Quality+in+the+Monkey%27s+Rostral+Supratemporal+Plane&rft.au=Kikuchi%2C+Y%3BHorwitz%2C+B%3BMishkin%2C+M&rft.aulast=Kikuchi&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Substrates Underlying Intermanual Transfer of Procedural Knowledge. II. Supplementary Motor Area T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334280; 4409913 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tanaka, S AU - Perez, M A AU - Reis, J AU - Wise, S P AU - Willingham, D T AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Supplementary motor area KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Substrates+Underlying+Intermanual+Transfer+of+Procedural+Knowledge.+II.+Supplementary+Motor+Area&rft.au=Tanaka%2C+S%3BPerez%2C+M+A%3BReis%2C+J%3BWise%2C+S+P%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Tanaka&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute and Gradual Increases in BDNF Concentration Elicit Distinct Signaling and Functions in Hippocampal Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334241; 4412721 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ji, Y. AU - Shen, W AU - Woo, N H AU - Feng, L AU - Duan, S AU - Lu, B. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Acute+and+Gradual+Increases+in+BDNF+Concentration+Elicit+Distinct+Signaling+and+Functions+in+Hippocampal+Neurons&rft.au=Ji%2C+Y.%3BShen%2C+W%3BWoo%2C+N+H%3BFeng%2C+L%3BDuan%2C+S%3BLu%2C+B.&rft.aulast=Ji&rft.aufirst=Y.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Nucleus Accumbens and Medial Frontal Cortex Activation in Appetitive Picture Processing T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334224; 4408197 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sabatinelli, D AU - Versace, F AU - Costa, V D AU - Bradley, M M AU - Lang, P J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Visual stimuli KW - Cortex (frontal) KW - Nucleus accumbens KW - Information processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+Nucleus+Accumbens+and+Medial+Frontal+Cortex+Activation+in+Appetitive+Picture+Processing&rft.au=Sabatinelli%2C+D%3BVersace%2C+F%3BCosta%2C+V+D%3BBradley%2C+M+M%3BLang%2C+P+J&rft.aulast=Sabatinelli&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Composition of the Synaptic PSD-95 Complex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334102; 4411521 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dosemeci, A AU - Makusky, A J AU - Yang, X AU - Tao-Cheng, J AU - Markey, S P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Postsynaptic density proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Composition+of+the+Synaptic+PSD-95+Complex&rft.au=Dosemeci%2C+A%3BMakusky%2C+A+J%3BYang%2C+X%3BTao-Cheng%2C+J%3BMarkey%2C+S+P&rft.aulast=Dosemeci&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction of the Adaptor Protein ARH with Bicaudal-D1 Suggests its Involvement in the Copi-Independent Golgi-ER Transport T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333916; 4411501 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mameza, M G AU - Gioio, A E AU - Kaplan, B B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Interaction+of+the+Adaptor+Protein+ARH+with+Bicaudal-D1+Suggests+its+Involvement+in+the+Copi-Independent+Golgi-ER+Transport&rft.au=Mameza%2C+M+G%3BGioio%2C+A+E%3BKaplan%2C+B+B&rft.aulast=Mameza&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Motor Complex Involved in Axonal Trafficking of Active Zone Precursors and Presynaptic Assembly T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333754; 4410938 JF - 36th Annual Meeting of the Society for Neuroscience AU - Cai, Q AU - Pan, P Y AU - Sheng, Z H Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Motors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+Novel+Motor+Complex+Involved+in+Axonal+Trafficking+of+Active+Zone+Precursors+and+Presynaptic+Assembly&rft.au=Cai%2C+Q%3BPan%2C+P+Y%3BSheng%2C+Z+H&rft.aulast=Cai&rft.aufirst=Q&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of a-synuclein Phosphorylation in Mammalian Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333683; 4412358 JF - 36th Annual Meeting of the Society for Neuroscience AU - Miller, D W AU - Patel, N AU - Clarimon, J AU - Cookson, M R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mammalian cells KW - Synuclein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+a-synuclein+Phosphorylation+in+Mammalian+Cells&rft.au=Miller%2C+D+W%3BPatel%2C+N%3BClarimon%2C+J%3BCookson%2C+M+R&rft.aulast=Miller&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insulin-like Growth Factor 1 (IGF1) Reduces Polyglutamine-expanded Androgen Receptor Toxicity in an SBMA Cell Model T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333167; 4412371 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ranganathan, S AU - Pennuto, M AU - Palazzolo, I AU - Howell, B AU - Fischbeck, K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Toxicity KW - Cell culture KW - Androgen receptors KW - Insulin-like growth factors KW - Insulin-like growth factor I KW - Sex hormones KW - Growth rate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Insulin-like+Growth+Factor+1+%28IGF1%29+Reduces+Polyglutamine-expanded+Androgen+Receptor+Toxicity+in+an+SBMA+Cell+Model&rft.au=Ranganathan%2C+S%3BPennuto%2C+M%3BPalazzolo%2C+I%3BHowell%2C+B%3BFischbeck%2C+K&rft.aulast=Ranganathan&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Primate Habenula in Reward Processing. I. Prediction of Negative Reward Value T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333006; 4410403 JF - 36th Annual Meeting of the Society for Neuroscience AU - Matsumoto, M AU - Hikosaka, O Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Reinforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Role+of+the+Primate+Habenula+in+Reward+Processing.+I.+Prediction+of+Negative+Reward+Value&rft.au=Matsumoto%2C+M%3BHikosaka%2C+O&rft.aulast=Matsumoto&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAC1 Mediates LPS-induced Superoxide from Microglia: The Role of Phagocytosis Receptors in Dopaminergic Neurotoxicity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332940; 4412417 JF - 36th Annual Meeting of the Society for Neuroscience AU - Block, M AU - Zhong, P AU - Pang, H AU - Wang, T AU - Wu, X. AU - Zhang, W AU - Dallas, S AU - Wilson, B AU - Miller, D AU - Hong, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neurotoxicity KW - Dopamine receptors KW - Microglia KW - Superoxide KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAC1+Mediates+LPS-induced+Superoxide+from+Microglia%3A+The+Role+of+Phagocytosis+Receptors+in+Dopaminergic+Neurotoxicity&rft.au=Block%2C+M%3BZhong%2C+P%3BPang%2C+H%3BWang%2C+T%3BWu%2C+X.%3BZhang%2C+W%3BDallas%2C+S%3BWilson%2C+B%3BMiller%2C+D%3BHong%2C+J&rft.aulast=Block&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotrophins and Integrins Regulate Survival of Hippocampal Neurons during Developmental Death Period T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332859; 4411125 JF - 36th Annual Meeting of the Society for Neuroscience AU - Murase, S AU - Owens, D F AU - Maughan, P H AU - Szklarczyk, A AU - Mckay, R D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Survival KW - Cell survival KW - Hippocampus KW - Integrins KW - Neurotrophins KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurotrophins+and+Integrins+Regulate+Survival+of+Hippocampal+Neurons+during+Developmental+Death+Period&rft.au=Murase%2C+S%3BOwens%2C+D+F%3BMaughan%2C+P+H%3BSzklarczyk%2C+A%3BMckay%2C+R+D&rft.aulast=Murase&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preferential Migration of Conditionally Immortalized Hippocampal Neuronal Cell Lines to Dentate Gyrus and Associated Functional Recovery in Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332610; 4411001 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pillai, R J AU - Chakravarthy, S AU - Alladi, P A AU - Balakrishnan, B AU - Ashok, G AU - Raju, T R AU - Panicker, M M AU - Kutty, B M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Rats KW - Recovery of function KW - Cell migration KW - Dentate gyrus KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Preferential+Migration+of+Conditionally+Immortalized+Hippocampal+Neuronal+Cell+Lines+to+Dentate+Gyrus+and+Associated+Functional+Recovery+in+Rats&rft.au=Pillai%2C+R+J%3BChakravarthy%2C+S%3BAlladi%2C+P+A%3BBalakrishnan%2C+B%3BAshok%2C+G%3BRaju%2C+T+R%3BPanicker%2C+M+M%3BKutty%2C+B+M&rft.aulast=Pillai&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Determinants for Polarized Targeting of PMCAs and the Turnover of Stereocilia Membrane Proteins in Mammalian Hair Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332578; 4406440 JF - 36th Annual Meeting of the Society for Neuroscience AU - Grati, M AU - Schneider, M AU - Aggarwal, N AU - Lipkow, K AU - Strehler, E E AU - Kachar, B AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Membrane proteins KW - Hair cells KW - Ca@@u2+@-transporting ATPase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Determinants+for+Polarized+Targeting+of+PMCAs+and+the+Turnover+of+Stereocilia+Membrane+Proteins+in+Mammalian+Hair+Cells&rft.au=Grati%2C+M%3BSchneider%2C+M%3BAggarwal%2C+N%3BLipkow%2C+K%3BStrehler%2C+E+E%3BKachar%2C+B%3BWenthold%2C+R+J&rft.aulast=Grati&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Presynaptic Kainate Receptors Bidirectionaly Regulate Thalamocortical Transmission during Development T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332468; 4412742 JF - 36th Annual Meeting of the Society for Neuroscience AU - Jouhanneau, J S AU - Isaac, J T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - Kainic acid receptors KW - Cortex KW - Thalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Presynaptic+Kainate+Receptors+Bidirectionaly+Regulate+Thalamocortical+Transmission+during+Development&rft.au=Jouhanneau%2C+J+S%3BIsaac%2C+J+T&rft.aulast=Jouhanneau&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Rearing Increases Fear Potentiated Startle in Rhesus Monkeys and Fluoxetine Ameliorates this Effect T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331971; 4408048 JF - 36th Annual Meeting of the Society for Neuroscience AU - Winslow, J T AU - Nelson, E E AU - Noble, P L AU - Wojteczko, K A AU - Ycu, E A AU - Pine, D S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fluoxetine KW - Startle response KW - Fear KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Adverse+Rearing+Increases+Fear+Potentiated+Startle+in+Rhesus+Monkeys+and+Fluoxetine+Ameliorates+this+Effect&rft.au=Winslow%2C+J+T%3BNelson%2C+E+E%3BNoble%2C+P+L%3BWojteczko%2C+K+A%3BYcu%2C+E+A%3BPine%2C+D+S&rft.aulast=Winslow&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Participation of Lys313-Ile333 Sequence of P2X@@d4@ Receptor in Agonist Binding and Transduction of Signals to the Channel Gate T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331968; 4407541 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yan, Z AU - Liang, Z AU - Obsil, T AU - Stojilkovic, S S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Purine P2X receptors KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Participation+of+Lys313-Ile333+Sequence+of+P2X%40%40d4%40+Receptor+in+Agonist+Binding+and+Transduction+of+Signals+to+the+Channel+Gate&rft.au=Yan%2C+Z%3BLiang%2C+Z%3BObsil%2C+T%3BStojilkovic%2C+S+S&rft.aulast=Yan&rft.aufirst=Z&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Filopodia and Branched Retraction Fibers by Transmembrane Agrin is Modulated by Agrin GAG Chains Via Activation of Cdc42 and Rac1 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331705; 4412698 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lin, L AU - Mccroskery, S AU - Ross, J M AU - Daniels, M P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Agrin KW - Rac1 protein KW - Cdc42 protein KW - Pseudopodia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Induction+of+Filopodia+and+Branched+Retraction+Fibers+by+Transmembrane+Agrin+is+Modulated+by+Agrin+GAG+Chains+Via+Activation+of+Cdc42+and+Rac1&rft.au=Lin%2C+L%3BMccroskery%2C+S%3BRoss%2C+J+M%3BDaniels%2C+M+P&rft.aulast=Lin&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DAPT, a Gamma-Secretase Inhibitor Downregulates Cdk5 Activity in Rat Cortical Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331381; 4407759 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kanungo, J AU - Zheng, Y AU - Pant, H C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cyclin-dependent kinase 5 KW - Secretase KW - Cortex KW - Inhibitors KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=DAPT%2C+a+Gamma-Secretase+Inhibitor+Downregulates+Cdk5+Activity+in+Rat+Cortical+Neurons&rft.au=Kanungo%2C+J%3BZheng%2C+Y%3BPant%2C+H+C&rft.aulast=Kanungo&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D@@d1@ and D@@d2@ Dopamine Receptor Interactions with the Na@@u+@/K@@u+@-Atpase Result in Reciprocal Modulation of Function T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331237; 4407577 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hazelwood, L A AU - Free, R B AU - Cabrera, D M AU - Neiman, J AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=D%40%40d1%40+and+D%40%40d2%40+Dopamine+Receptor+Interactions+with+the+Na%40%40u%2B%40%2FK%40%40u%2B%40-Atpase+Result+in+Reciprocal+Modulation+of+Function&rft.au=Hazelwood%2C+L+A%3BFree%2C+R+B%3BCabrera%2C+D+M%3BNeiman%2C+J%3BSibley%2C+D+R&rft.aulast=Hazelwood&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State-Dependent cAMP Sensitivity of Feedforward Inhibition in the Hippocampal Mossy Fiber Pathway T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331215; 4406327 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pelkey, K A AU - Topolnik, L AU - Lacaille, J C AU - Mcbain, C J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Hippocampus KW - Cyclic AMP KW - Mossy fibers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=State-Dependent+cAMP+Sensitivity+of+Feedforward+Inhibition+in+the+Hippocampal+Mossy+Fiber+Pathway&rft.au=Pelkey%2C+K+A%3BTopolnik%2C+L%3BLacaille%2C+J+C%3BMcbain%2C+C+J&rft.aulast=Pelkey&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Phosphorylation of Septin SEPT5 at Serine 327 Regulates Exocytosis T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330936; 4407655 JF - 36th Annual Meeting of the Society for Neuroscience AU - Amin, N AU - Kesavapany, S AU - Kanungo, J AU - Zheng, Y AU - Sihag, R AU - Albers, W AU - Grant, P AU - Pant, H C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Septin KW - Serine KW - Exocytosis KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cdk5+Phosphorylation+of+Septin+SEPT5+at+Serine+327+Regulates+Exocytosis&rft.au=Amin%2C+N%3BKesavapany%2C+S%3BKanungo%2C+J%3BZheng%2C+Y%3BSihag%2C+R%3BAlbers%2C+W%3BGrant%2C+P%3BPant%2C+H+C&rft.aulast=Amin&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptic Plasticity (and Lack Thereof) in Hippocampal CA2 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330688; 4406344 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhao, M AU - Dudek, S M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Hippocampus KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synaptic+Plasticity+%28and+Lack+Thereof%29+in+Hippocampal+CA2&rft.au=Zhao%2C+M%3BDudek%2C+S+M&rft.aulast=Zhao&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Activity in the Zona Incerta of the Monkey is Related to Motivational States in a Reward Schedule Task T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330510; 4408102 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ravel, S P AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Reinforcement KW - Zona incerta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Activity+in+the+Zona+Incerta+of+the+Monkey+is+Related+to+Motivational+States+in+a+Reward+Schedule+Task&rft.au=Ravel%2C+S+P%3BRichmond%2C+B+J&rft.aulast=Ravel&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The A-Type K@@u+@ Channel Subunit Kv4.2 Controls Functional NR2B Activity through a Ca@@u2+@-Dependent Mechanism in Hippocampal CA1 Pyramidal Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329417; 4406338 JF - 36th Annual Meeting of the Society for Neuroscience AU - Jung, S AU - Kim, J AU - Hoffman, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Potassium channels KW - Pyramidal cells KW - Potassium channels (voltage-gated) KW - Calcium KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+A-Type+K%40%40u%2B%40+Channel+Subunit+Kv4.2+Controls+Functional+NR2B+Activity+through+a+Ca%40%40u2%2B%40-Dependent+Mechanism+in+Hippocampal+CA1+Pyramidal+Neurons&rft.au=Jung%2C+S%3BKim%2C+J%3BHoffman%2C+D+A&rft.aulast=Jung&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional Expression of Fmr1, Fxr1, and Fxr2 mRNAs in Brains of Adult Male and Female Wild-Type Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329313; 4409021 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yang, C H AU - Xing, G Q AU - Smith, C B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Brain KW - MRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regional+Expression+of+Fmr1%2C+Fxr1%2C+and+Fxr2+mRNAs+in+Brains+of+Adult+Male+and+Female+Wild-Type+Mice&rft.au=Yang%2C+C+H%3BXing%2C+G+Q%3BSmith%2C+C+B&rft.aulast=Yang&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential Failure in a Presynaptic CNS Nerve Terminal Following a Train of Action Potentials T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329311; 4406311 JF - 36th Annual Meeting of the Society for Neuroscience AU - Paradiso, K G AU - Wu, L. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Action potential KW - Central nervous system KW - Nerve endings KW - Nerves KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Action+Potential+Failure+in+a+Presynaptic+CNS+Nerve+Terminal+Following+a+Train+of+Action+Potentials&rft.au=Paradiso%2C+K+G%3BWu%2C+L.&rft.aulast=Paradiso&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAP Kinase Role in p53-Mediated Apoptosis in Rat Neural Af5 Cells after Hydrogen Peroxide T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329031; 4408546 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mcneil-Blue, C AU - Merrick, B A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Hydrogen peroxide KW - MAP kinase KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAP+Kinase+Role+in+p53-Mediated+Apoptosis+in+Rat+Neural+Af5+Cells+after+Hydrogen+Peroxide&rft.au=Mcneil-Blue%2C+C%3BMerrick%2C+B+A&rft.aulast=Mcneil-Blue&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curcumin Protects Dopaminergic Neurons through Inhibition of Microglia Overactivation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328510; 4408260 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yang, S AU - Yang, Z AU - Pang, H AU - Gao, X AU - Wilson, B C AU - Block, M AU - Hong, J S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Curcumin KW - Microglia KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Curcumin+Protects+Dopaminergic+Neurons+through+Inhibition+of+Microglia+Overactivation&rft.au=Yang%2C+S%3BYang%2C+Z%3BPang%2C+H%3BGao%2C+X%3BWilson%2C+B+C%3BBlock%2C+M%3BHong%2C+J+S&rft.aulast=Yang&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Signals Related to Predicted and Elapsed Delay to Reward in the Primate Anterior Cingulate Cortex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328292; 4410389 JF - 36th Annual Meeting of the Society for Neuroscience AU - Minamimoto, T AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Reinforcement KW - Cortex (cingulate) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Signals+Related+to+Predicted+and+Elapsed+Delay+to+Reward+in+the+Primate+Anterior+Cingulate+Cortex&rft.au=Minamimoto%2C+T%3BRichmond%2C+B+J&rft.aulast=Minamimoto&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GIPC, a Single PDZ Domain-Containing Protein, Interacts with the NMDA Receptor and Regulates its Surface Expression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328138; 4406207 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yi, Z. AU - Petralia, R S AU - Prybylowski, K AU - Sans, N AU - Wang, Y X AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GIPC%2C+a+Single+PDZ+Domain-Containing+Protein%2C+Interacts+with+the+NMDA+Receptor+and+Regulates+its+Surface+Expression&rft.au=Yi%2C+Z.%3BPetralia%2C+R+S%3BPrybylowski%2C+K%3BSans%2C+N%3BWang%2C+Y+X%3BWenthold%2C+R+J&rft.aulast=Yi&rft.aufirst=Z.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SALM Family of Adhesion-Like Molecules Forms Heteromeric and Homomeric Complexes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40327909; 4406198 JF - 36th Annual Meeting of the Society for Neuroscience AU - Seabold, G K AU - Wang, C Y AU - Chang, K AU - Petralia, R S AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+SALM+Family+of+Adhesion-Like+Molecules+Forms+Heteromeric+and+Homomeric+Complexes&rft.au=Seabold%2C+G+K%3BWang%2C+C+Y%3BChang%2C+K%3BPetralia%2C+R+S%3BWenthold%2C+R+J&rft.aulast=Seabold&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective White Matter Differences in Spasmodic Dysphonia: A DTI Study T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40327155; 4408296 JF - 36th Annual Meeting of the Society for Neuroscience AU - Simonyan, K AU - Tovar-Moll, F AU - Ostuni, J AU - Hattori, N AU - Hallett, M AU - Ludlow, C L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Substantia alba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+White+Matter+Differences+in+Spasmodic+Dysphonia%3A+A+DTI+Study&rft.au=Simonyan%2C+K%3BTovar-Moll%2C+F%3BOstuni%2C+J%3BHattori%2C+N%3BHallett%2C+M%3BLudlow%2C+C+L&rft.aulast=Simonyan&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of N-Methyl-D-Aspartate (NMDA) Receptors with Flotillin-1, a Lipid Raft-Associated Protein T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40325063; 4406197 JF - 36th Annual Meeting of the Society for Neuroscience AU - Swanwick, C C AU - Chang, K AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Lipids KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interaction+of+N-Methyl-D-Aspartate+%28NMDA%29+Receptors+with+Flotillin-1%2C+a+Lipid+Raft-Associated+Protein&rft.au=Swanwick%2C+C+C%3BChang%2C+K%3BWenthold%2C+R+J&rft.aulast=Swanwick&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Valproic Acid-induced BDNF Promoter III Activity in Cortical Neurons and Neuroblastoma Cells: Role of HDAC Subtypes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324902; 4405944 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yasuda, S AU - Liang, M AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Promoters KW - Neuroblastoma cells KW - Histone deacetylase KW - Cortex KW - Brain-derived neurotrophic factor KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Valproic+Acid-induced+BDNF+Promoter+III+Activity+in+Cortical+Neurons+and+Neuroblastoma+Cells%3A+Role+of+HDAC+Subtypes&rft.au=Yasuda%2C+S%3BLiang%2C+M%3BChuang%2C+D&rft.aulast=Yasuda&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor Receptors Differentially Regulate the Self-Renewing and Neurogenic Properties of Cortical Neural Stem Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324506; 4409117 JF - 36th Annual Meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y H AU - Barker, J L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Stem cells KW - Fibroblast growth factor receptors KW - Cortex KW - Neural stem cells KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Fibroblast+Growth+Factor+Receptors+Differentially+Regulate+the+Self-Renewing+and+Neurogenic+Properties+of+Cortical+Neural+Stem+Cells&rft.au=Maric%2C+D%3BChang%2C+Y+H%3BBarker%2C+J+L&rft.aulast=Maric&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA-Induced Death of Hippocampal CA1 Neurons in Slice Culture is Mediated by Mitochondrial Damage T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324454; 4408464 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pivovarova, N B AU - Brantner, C A AU - Winters, C A AU - Andrews, S B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Mitochondria KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NMDA-Induced+Death+of+Hippocampal+CA1+Neurons+in+Slice+Culture+is+Mediated+by+Mitochondrial+Damage&rft.au=Pivovarova%2C+N+B%3BBrantner%2C+C+A%3BWinters%2C+C+A%3BAndrews%2C+S+B&rft.aulast=Pivovarova&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BAG1 Overexpression Reduces Manic-Like and Depression-Like Behavior in Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40323397; 4406001 JF - 36th Annual Meeting of the Society for Neuroscience AU - Maeng, S AU - Creson, T AU - Shaltiel, G AU - Gould, T AU - Du, J. AU - Chen, G AU - Reed, J C AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40323397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BAG1+Overexpression+Reduces+Manic-Like+and+Depression-Like+Behavior+in+Mice&rft.au=Maeng%2C+S%3BCreson%2C+T%3BShaltiel%2C+G%3BGould%2C+T%3BDu%2C+J.%3BChen%2C+G%3BReed%2C+J+C%3BManji%2C+H+K&rft.aulast=Maeng&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PET Imaging with [11C]PBR28 can Localize and Quantify Up-Regulated Peripheral Benzodiazepine Receptors Associated with Cerebral Ischemia in Rat T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40322557; 4405880 JF - 36th Annual Meeting of the Society for Neuroscience AU - Imaizumi, M AU - Kim, H AU - Zoghbi, S S AU - Briard, E AU - Hong, J AU - Musachio, J L AU - Chuang, D AU - Pike, V W AU - Innis, R B AU - Fujita, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ischemia KW - Benzodiazepine receptors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40322557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PET+Imaging+with+%5B11C%5DPBR28+can+Localize+and+Quantify+Up-Regulated+Peripheral+Benzodiazepine+Receptors+Associated+with+Cerebral+Ischemia+in+Rat&rft.au=Imaizumi%2C+M%3BKim%2C+H%3BZoghbi%2C+S+S%3BBriard%2C+E%3BHong%2C+J%3BMusachio%2C+J+L%3BChuang%2C+D%3BPike%2C+V+W%3BInnis%2C+R+B%3BFujita%2C+M&rft.aulast=Imaizumi&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone Deacetylase Inhibitors Valproate and Pivanex in the Forced Swim Test: Strain Dependent Outcomes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40322292; 4406020 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rowe, M AU - Wiest, C AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Histone deacetylase KW - Histones KW - Inhibitors KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40322292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Histone+Deacetylase+Inhibitors+Valproate+and+Pivanex+in+the+Forced+Swim+Test%3A+Strain+Dependent+Outcomes&rft.au=Rowe%2C+M%3BWiest%2C+C%3BChuang%2C+D&rft.aulast=Rowe&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hippocampal GluR1 AMPA Receptor Trafficking is Involved in Mood Disorder-Like Behaviors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40319599; 4406009 JF - 36th Annual Meeting of the Society for Neuroscience AU - Creson, T K AU - Du, J. AU - Chen, G AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Protein transport KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Mood KW - Glutamic acid receptors (ionotropic) KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40319599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Hippocampal+GluR1+AMPA+Receptor+Trafficking+is+Involved+in+Mood+Disorder-Like+Behaviors&rft.au=Creson%2C+T+K%3BDu%2C+J.%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Creson&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GluR6 Knock-Out Mice Concurrently Display Multiple Behaviors Related to Manic Symptoms T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40316394; 4406008 JF - 36th Annual Meeting of the Society for Neuroscience AU - Shaltiel, G AU - Maeng, S AU - Rogawski, M AU - Gasior, M AU - Chen, G AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40316394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GluR6+Knock-Out+Mice+Concurrently+Display+Multiple+Behaviors+Related+to+Manic+Symptoms&rft.au=Shaltiel%2C+G%3BMaeng%2C+S%3BRogawski%2C+M%3BGasior%2C+M%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Shaltiel&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages. AN - 68848788; 16930534 AB - Previously, we showed that PMA activation of human monocyte-derived macrophages stimulates macropinocytosis (i.e., fluid-phase endocytosis) of LDL and transforms these macrophages into foam cells. The current study aimed to learn which PKC isoenzymes mediate cholesterol accumulation in PMA-activated human macrophages incubated with LDL. Cholesterol accumulation by PMA-activated macrophages incubated with LDL was nearly completely inhibited (>85%) by the pan PKC inhibitors Go6850, Go6983, and RO 32-0432, but only was inhibited about 50% by the classical group PKC inhibitor, Go6976. This indicated that cholesterol accumulation was mediated by both a classical group and some other PKC isoenzyme. PKC beta was determined to be the classical group isoenzyme that mediated PMA-stimulated cholesterol accumulation. A pseudosubstrate myristoylated peptide inhibitor of PKC alpha and beta showed partial inhibition (congruent with 50%) of cholesterol accumulation. However, a small molecule inhibitor of PKC alpha, HBDDE, show minimal inhibition of cholesterol accumulation while a small molecule inhibitor of PKC beta, LY333513, could completely account for the inhibition of cholesterol accumulation by the classical group PKC isoenzyme. Thus, our findings show that beta and some other PKC isoenzyme, most likely delta, mediate cholesterol accumulation when macropinocytosis of LDL is stimulated in PMA-activated human monocyte-derived macrophages. JF - Biochemical and biophysical research communications AU - Ma, Hong-Tao AU - Lin, Wan-Wan AU - Zhao, Bin AU - Wu, Wen-Tung AU - Huang, Wei AU - Li, Yifu AU - Jones, Nancy L AU - Kruth, Howard S AD - Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1422, USA. Y1 - 2006/10/13/ PY - 2006 DA - 2006 Oct 13 SP - 214 EP - 220 VL - 349 IS - 1 SN - 0006-291X, 0006-291X KW - Enzyme Inhibitors KW - 0 KW - Isoenzymes KW - Cholesterol KW - 97C5T2UQ7J KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C beta KW - Protein Kinase C-delta KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Atherosclerosis -- pathology KW - Foam Cells -- metabolism KW - Cells, Cultured KW - Humans KW - Monocytes -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Atherosclerosis -- metabolism KW - Models, Biological KW - Signal Transduction KW - Tetradecanoylphorbol Acetate -- metabolism KW - Cholesterol -- metabolism KW - Protein Kinase C -- chemistry KW - Protein Kinase C-delta -- physiology KW - Protein Kinase C -- physiology KW - Protein Kinase C-delta -- chemistry KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68848788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Protein+kinase+C+beta+and+delta+isoenzymes+mediate+cholesterol+accumulation+in+PMA-activated+macrophages.&rft.au=Ma%2C+Hong-Tao%3BLin%2C+Wan-Wan%3BZhao%2C+Bin%3BWu%2C+Wen-Tung%3BHuang%2C+Wei%3BLi%2C+Yifu%3BJones%2C+Nancy+L%3BKruth%2C+Howard+S&rft.aulast=Ma&rft.aufirst=Hong-Tao&rft.date=2006-10-13&rft.volume=349&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Kinetics of Genes Encoding Innate Host Defense Molecules in Human Monocytes Infected with Rhizopus oryzae T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40254222; 4367446 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Cortez, Karoll J AU - Lyman, Caron A AU - Lempicki, Richard A AU - Ren, Ping AU - Cotten, Catherine AU - Roilides, Emmanuel AU - Kottilil, Shyam AU - Walsh, Thomas J Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Kinetics KW - Monocytes KW - Rhizopus oryzae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Kinetics+of+Genes+Encoding+Innate+Host+Defense+Molecules+in+Human+Monocytes+Infected+with+Rhizopus+oryzae&rft.au=Cortez%2C+Karoll+J%3BLyman%2C+Caron+A%3BLempicki%2C+Richard+A%3BRen%2C+Ping%3BCotten%2C+Catherine%3BRoilides%2C+Emmanuel%3BKottilil%2C+Shyam%3BWalsh%2C+Thomas+J&rft.aulast=Cortez&rft.aufirst=Karoll&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathogenesis of Acute HIV Infection T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40252495; 4367793 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Brenchley, Jason Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Infectious diseases KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40252495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Pathogenesis+of+Acute+HIV+Infection&rft.au=Brenchley%2C+Jason&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Novel Human Pathogen Granulibacter bethesdensis Causes Necrotizing Lymphadenitis in Chronic Granulomatous Disease T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40250358; 4368034 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Greenberg, David E AU - Zelazny, Adrian M AU - Stock, Frida AU - Shoffner, Adam R AU - Wasserman, Richard L AU - Welch, David F AU - Malech, Harry L AU - Murray, Patrick R AU - Holland, Steven M Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Pathogens KW - Chronic granulomatous disease KW - Lymphadenitis KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40250358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=The+Novel+Human+Pathogen+Granulibacter+bethesdensis+Causes+Necrotizing+Lymphadenitis+in+Chronic+Granulomatous+Disease&rft.au=Greenberg%2C+David+E%3BZelazny%2C+Adrian+M%3BStock%2C+Frida%3BShoffner%2C+Adam+R%3BWasserman%2C+Richard+L%3BWelch%2C+David+F%3BMalech%2C+Harry+L%3BMurray%2C+Patrick+R%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Susceptibility: Understanding Mechanisms of Action of the New Immunomodulating Treatments T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40248500; 4367813 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Holland, Steven Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40248500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Susceptibility%3A+Understanding+Mechanisms+of+Action+of+the+New+Immunomodulating+Treatments&rft.au=Holland%2C+Steven&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infectious Complications of Alemtuzumab and Other Anti-Lymphocytic Agents T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40247343; 4367816 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Gea-Banacloche, Juan Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Infectious+Complications+of+Alemtuzumab+and+Other+Anti-Lymphocytic+Agents&rft.au=Gea-Banacloche%2C+Juan&rft.aulast=Gea-Banacloche&rft.aufirst=Juan&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amphotericin B and the Cnundrum of Toxicity vs. Efficacy: How can We Kill More Fungi and Fewer Nephrons? T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40245788; 4367758 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Walsh, Thomas J Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Toxicity KW - Fungi KW - Airborne microorganisms KW - Nephrons KW - Amphotericin B KW - Kidneys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40245788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Amphotericin+B+and+the+Cnundrum+of+Toxicity+vs.+Efficacy%3A+How+can+We+Kill+More+Fungi+and+Fewer+Nephrons%3F&rft.au=Walsh%2C+Thomas+J&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymerizing Actin Positions Primed Integrins along the Leading Edge of Migrating Cells T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40307525; 4398259 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Galbraith, C AU - Yamada, K AU - Galbraith, J Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Actin KW - Integrins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40307525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Polymerizing+Actin+Positions+Primed+Integrins+along+the+Leading+Edge+of+Migrating+Cells&rft.au=Galbraith%2C+C%3BYamada%2C+K%3BGalbraith%2C+J&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SPIO-Labeled Chondrocytes for MRI Evaluation of Cell Distribution in Tissue Engineered Constructs T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40306363; 4398440 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Ramaswamy, S AU - Uluer, M AU - Zhang, Z AU - Spencer, R G Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Magnetic resonance imaging KW - Chondrocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40306363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=SPIO-Labeled+Chondrocytes+for+MRI+Evaluation+of+Cell+Distribution+in+Tissue+Engineered+Constructs&rft.au=Ramaswamy%2C+S%3BUluer%2C+M%3BZhang%2C+Z%3BSpencer%2C+R+G&rft.aulast=Ramaswamy&rft.aufirst=S&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maximum Likelihood Analysis of Molecular Motor Data T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40303788; 4398574 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Milescu, L S AU - Yildiz, A AU - Selvin, P R AU - Sachs, F Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Motors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40303788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Maximum+Likelihood+Analysis+of+Molecular+Motor+Data&rft.au=Milescu%2C+L+S%3BYildiz%2C+A%3BSelvin%2C+P+R%3BSachs%2C+F&rft.aulast=Milescu&rft.aufirst=L&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational and Experimental Studies of Bursting in Respiratory Neurons T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40296632; 4397563 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Milescu, L AU - Mogri, M AU - Ptak, K AU - Smith, J Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Computational neuroscience KW - Respiration KW - Neurons KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40296632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Computational+and+Experimental+Studies+of+Bursting+in+Respiratory+Neurons&rft.au=Milescu%2C+L%3BMogri%2C+M%3BPtak%2C+K%3BSmith%2C+J&rft.aulast=Milescu&rft.aufirst=L&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl. AN - 68956207; 17015841 AB - Glycerophosphocholine (GPC) is an osmoprotective compatible and counteracting organic osmolyte that accumulates in renal inner medullary cells in response to high NaCl and urea. We previously found that high NaCl increases GPC in renal [Madin-Darby canine kidney (MDCK)] cells. The GPC is derived from phosphatidylcholine, catalyzed by a phospholipase that was not identified at that time. Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine. The purpose of the present study was to test whether NTE contributes to the high NaCl-induced increase of GPC synthesis in renal cells. We find that in mouse inner medullary collecting duct cells, high NaCl increases NTE mRNA within 8 h and NTE protein within 16 h. Diisopropyl fluorophosphate, which inhibits NTE esterase activity, reduces GPC accumulation, as does an siRNA that specifically reduces NTE protein abundance. The 20-h half-life of NTE mRNA is unaffected by high NaCl. TonEBP/OREBP is a transcription factor that is activated by high NaCl. Knockdown of TonEBP/OREBP by a specific siRNA inhibits the high NaCl-induced increase of NTE mRNA. Further, the lower renal inner medullary interstitial NaCl concentration that occurs chronically in ClCK1-/- mice and acutely in normal mice given furosemide is associated with lower NTE mRNA and protein. We conclude that high NaCl increases transcription of NTE, likely mediated by TonEBP/OREBP, and that the resultant increase of NTE expression contributes to increased production and accumulation of GPC in mammalian renal cells in tissue culture and in vivo. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gallazzini, Morgan AU - Ferraris, Joan D AU - Kunin, Margarita AU - Morris, Ryan G AU - Burg, Maurice B AD - Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892-1603, USA. gallazzinim@nhlbi.nih.gov Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15260 EP - 15265 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - Sodium Chloride KW - 451W47IQ8X KW - Glycerylphosphorylcholine KW - 60M22SGW66 KW - Carboxylic Ester Hydrolases KW - EC 3.1.1.- KW - neurotoxic esterase KW - Index Medicus KW - Animals KW - Mice KW - Cell Line KW - Carboxylic Ester Hydrolases -- physiology KW - Glycerylphosphorylcholine -- metabolism KW - Sodium Chloride -- metabolism KW - Kidney -- enzymology KW - Kidney -- cytology KW - Glycerylphosphorylcholine -- biosynthesis KW - Water-Electrolyte Balance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68956207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Neuropathy+target+esterase+catalyzes+osmoprotective+renal+synthesis+of+glycerophosphocholine+in+response+to+high+NaCl.&rft.au=Gallazzini%2C+Morgan%3BFerraris%2C+Joan+D%3BKunin%2C+Margarita%3BMorris%2C+Ryan+G%3BBurg%2C+Maurice+B&rft.aulast=Gallazzini&rft.aufirst=Morgan&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15260&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1995 Feb;268(2 Pt 1):C402-12 [7864079] J Biol Chem. 1994 Nov 25;269(47):29379-81 [7961914] Int J Biochem Cell Biol. 1995 Oct;27(10):1055-63 [7496995] J Biol Chem. 1996 Aug 2;271(31):18318-21 [8702469] Biochem J. 1998 May 15;332 ( Pt 1):1-4 [9576844] Am J Physiol. 1998 Jun;274(6 Pt 2):F1167-73 [9841510] Nat Genet. 1999 Jan;21(1):95-8 [9916798] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2538-42 [10051678] J Biol Chem. 1999 Apr 2;274(14):9400-8 [10092620] Nat Biotechnol. 2005 Feb;23(2):222-6 [15619617] J Neurosci. 2005 Mar 16;25(11):2865-73 [15772346] Am J Physiol Renal Physiol. 2005 Sep;289(3):F506-11 [15840767] FEMS Yeast Res. 2006 Mar;6(2):205-17 [16487344] Biochem J. 1999 Dec 15;344 Pt 3:625-31 [10585848] Am J Physiol Renal Physiol. 2000 Feb;278(2):F209-18 [10662725] Biochem Biophys Res Commun. 2000 Apr 2;270(1):52-61 [10733904] J Biol Chem. 2001 Feb 9;276(6):3756-63 [11078727] J Am Soc Nephrol. 2003 Feb;14(2):283-8 [12538727] J Biol Chem. 2003 Mar 7;278(10):8820-5 [12514188] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5075-80 [15051870] J Biol Chem. 2004 Jun 4;279(23):24024-33 [15044461] Biochem J. 1969 Oct;114(4):711-7 [4310054] Science. 1982 Sep 24;217(4566):1214-22 [7112124] Am J Physiol. 1989 Oct;257(4 Pt 1):C795-801 [2801928] Am J Physiol. 1990 Nov;259(5 Pt 2):F847-58 [2240234] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7820-4 [1652765] Physiol Rev. 1991 Oct;71(4):1081-115 [1924548] Biochim Biophys Acta. 1993 Jun 5;1148(2):331-41 [8504126] Biochim Biophys Acta. 1993 Jul 25;1150(1):25-34 [8392869] Am J Physiol. 1993 Sep;265(3 Pt 2):F416-24 [8214101] Am J Physiol. 1995 Jul;269(1 Pt 1):C35-41 [7631758] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. AN - 68955349; 17008406 AB - Nonspecific protein-DNA interactions are inherently dynamic and involve both diffusion of the protein along the DNA and hopping of the protein from one DNA molecule or segment to another. Understanding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and dynamics is challenging because the experimental observables are an ensemble average of many rapidly exchanging states. By using a variety of NMR spectroscopic techniques, including relaxation analysis, paramagnetic relaxation enhancement, and residual dipolar couplings, we have characterized structural and kinetic aspects of the interaction of the HoxD9 homeodomain with a nonspecific, 24-bp DNA duplex in a system in which the protein is not constrained to any particular site. The data reveal that HoxD9 binds to nonspecific DNA with the same binding mode and orientation as that observed in the specific complex. The mobility, however, of Arg side-chains contacting the DNA is increased in the nonspecific complex relative to the specific one. The kinetics of intermolecular translocation between two different nonspecific DNA molecules have also been analyzed and reveal that at high DNA concentrations (such as those present in vivo) direct transfer from one nonspecific complex to another nonspecific DNA molecule occurs without going through the intermediary of free protein. This finding provides a simple mechanism for accelerating the target search in vivo for the specific site in a sea of nonspecific sites by permitting more effective sampling of available DNA sites as the protein jumps from one segment to another. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Iwahara, Junji AU - Zweckstetter, Markus AU - Clore, G Marius AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15062 EP - 15067 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - HOXD9 protein, human KW - 0 KW - Homeodomain Proteins KW - Neoplasm Proteins KW - Nucleic Acid Heteroduplexes KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Kinetics KW - Humans KW - Neoplasm Proteins -- genetics KW - Protein Binding -- genetics KW - Neoplasm Proteins -- chemistry KW - Neoplasm Proteins -- metabolism KW - Nucleic Acid Heteroduplexes -- genetics KW - Nucleic Acid Heteroduplexes -- metabolism KW - Homeodomain Proteins -- genetics KW - Nuclear Magnetic Resonance, Biomolecular KW - DNA -- metabolism KW - Nucleic Acid Heteroduplexes -- chemistry KW - Homeodomain Proteins -- metabolism KW - DNA -- chemistry KW - Homeodomain Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68955349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=NMR+structural+and+kinetic+characterization+of+a+homeodomain+diffusing+and+hopping+on+nonspecific+DNA.&rft.au=Iwahara%2C+Junji%3BZweckstetter%2C+Markus%3BClore%2C+G+Marius&rft.aulast=Iwahara&rft.aufirst=Junji&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15062&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomol NMR. 2002 Jun;23(2):127-37 [12153038] J Am Chem Soc. 2002 Apr 24;124(16):4463-72 [11960476] J Am Chem Soc. 2004 May 12;126(18):5879-96 [15125681] Nucleic Acids Res. 2004;32(10):3040-52 [15178741] Biophys J. 2004 Jun;86(6):3444-60 [15189846] Science. 2004 Jul 16;305(5682):386-9 [15256668] J Am Chem Soc. 2004 Oct 13;126(40):12800-8 [15469275] J Biol Chem. 1989 Jan 15;264(2):675-8 [2642903] Proc Natl Acad Sci U S A. 1990 Jun;87(11):4093-7 [1971945] Cell. 1990 Nov 2;63(3):579-90 [1977522] EMBO J. 1993 May;12(5):1781-95 [8491171] Cell. 1994 Jul 29;78(2):211-23 [8044836] Nat Struct Biol. 1995 May;2(5):386-94 [7664096] FEBS Lett. 1996 Dec 2;398(2-3):279-84 [8977123] Trends Biotechnol. 1998 Jan;16(1):22-34 [9470228] J Magn Reson. 1998 Apr;131(2):373-8 [9571116] Nat Struct Biol. 1998 Aug;5(8):692-7 [9699632] J Am Chem Soc. 2005 Apr 27;127(16):5826-32 [15839680] J Am Chem Soc. 2006 Jan 18;128(2):404-5 [16402815] Science. 2006 Feb 24;311(5764):1153-7 [16497933] Nature. 2006 Apr 27;440(7088):1227-30 [16642002] Mol Cell. 2000 May;5(5):889-95 [10882125] J Am Chem Soc. 2002 Jan 23;124(3):372-3 [11792196] Proteins. 2003 Jun 1;51(4):544-51 [12784213] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. AN - 68945500; 17015825 AB - Alcoholism is a chronic relapsing disorder with substantial heritability. Uncovering gene-environment interactions underlying this disease process can aid identification of novel treatment targets. Here, we found a lowered threshold for stress-induced reinstatement of alcohol seeking in Marchigian-Sardinian Preferring (msP) rats genetically selected for high alcohol preference. In situ hybridization for a panel of 20 stress-related genes in 16 brain regions was used to screen for differential gene expression that may underlie this behavioral phenotype. An innate up-regulation of the Crhr1 transcript, encoding the corticotropin-releasing hormone receptor 1 (CRH-R1), was found in several limbic brain areas of msP rats genetically selected for high alcohol preference, was associated with genetic polymorphism of the Crhr1 promoter, and was accompanied by increased CRH-R1 density. A selective CRH-R1 antagonist (antalarmin, 10-20 mg/kg) was devoid of effects on operant alcohol self-administration in unselected Wistar rats but significantly suppressed this behavior in the msP line. Stress-induced reinstatement of alcohol seeking was not significantly affected by antalarmin in Wistar rats but was fully blocked in msP animals. These data demonstrate that Crhr1 genotype and expression interact with environmental stress to reinstate alcohol-seeking behavior. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hansson, A C AU - Cippitelli, A AU - Sommer, W H AU - Fedeli, A AU - Björk, K AU - Soverchia, L AU - Terasmaa, A AU - Massi, M AU - Heilig, M AU - Ciccocioppo, R AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15236 EP - 15241 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - CRF receptor type 1 KW - 0 KW - Receptors, Corticotropin-Releasing Hormone KW - Index Medicus KW - Rats KW - Genotype KW - Animals KW - Rats, Mutant Strains KW - Rats, Wistar KW - Behavior, Animal -- physiology KW - Recurrence KW - Male KW - Genetic Variation KW - Stress, Physiological -- psychology KW - Receptors, Corticotropin-Releasing Hormone -- physiology KW - Receptors, Corticotropin-Releasing Hormone -- biosynthesis KW - Stress, Physiological -- genetics KW - Receptors, Corticotropin-Releasing Hormone -- genetics KW - Genetic Predisposition to Disease KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68945500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Variation+at+the+rat+Crhr1+locus+and+sensitivity+to+relapse+into+alcohol+seeking+induced+by+environmental+stress.&rft.au=Hansson%2C+A+C%3BCippitelli%2C+A%3BSommer%2C+W+H%3BFedeli%2C+A%3BBj%C3%B6rk%2C+K%3BSoverchia%2C+L%3BTerasmaa%2C+A%3BMassi%2C+M%3BHeilig%2C+M%3BCiccocioppo%2C+R&rft.aulast=Hansson&rft.aufirst=A&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15236&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2002 Sep;27(3):391-9 [12225696] Exp Brain Res. 2001 Jul;139(1):39-52 [11482842] Science. 2002 May 3;296(5569):931-3 [11988580] J Neurosci. 2002 Sep 15;22(18):7856-61 [12223538] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] J Neurosci. 2003 Jul 9;23(14):6013-22 [12853419] Neuropsychopharmacology. 2003 Aug;28(8):1546-52 [12813472] JAMA. 2004 Mar 10;291(10):1238-45 [15010446] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Pharmacol Exp Ther. 2004 Nov;311(2):427-40 [15297468] Am Psychol. 1986 Jul;41(7):765-82 [3527003] Physiol Behav. 1995 Jun;57(6):1181-5 [7652041] Psychopharmacology (Berl). 1995 Dec;122(4):369-73 [8657835] Endocrinology. 1996 Dec;137(12):5747-50 [8940412] Neuropsychopharmacology. 1997 Nov;17(5):308-16 [9348546] J Pharmacol Exp Ther. 1998 Jul;286(1):459-68 [9655891] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13 [9689128] Psychopharmacology (Berl). 1999 May;144(2):151-7 [10394996] Pharmacol Biochem Behav. 2004 Nov;79(3):439-50 [15582015] Pharmacol Biochem Behav. 2004 Dec;79(4):671-89 [15582675] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Nat Neurosci. 2005 Nov;8(11):1431-6 [16251982] Mol Psychiatry. 2006 Jun;11(6):594-602 [16550213] Pharmacol Ther. 2006 Sep;111(3):855-76 [16545872] Addict Biol. 2006 Sep;11(3-4):193-4 [16961757] Addict Biol. 2006 Sep;11(3-4):339-55 [16961763] Alcohol Clin Exp Res. 2002 Oct;26(10):1494-501 [12394282] Neuropsychopharmacology. 2000 Jun;22(6):581-94 [10788758] Am J Psychiatry. 2001 Apr;158(4):582-6 [11282692] FASEB J. 2002 Jan;16(1):27-35 [11772933] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Gastrinomas and CCKomas: Recent Advances T2 - 2006 Benzon Symposia: The New Biology of the Gastrin-Cholecystokinin Family of Hormones AN - 40494539; 4496916 DE: JF - 2006 Benzon Symposia: The New Biology of the Gastrin-Cholecystokinin Family of Hormones AU - Jensen, R T Y1 - 2006/10/09/ PY - 2006 DA - 2006 Oct 09 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40494539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Benzon+Symposia%3A+The+New+Biology+of+the+Gastrin-Cholecystokinin+Family+of+Hormones&rft.atitle=Gastrinomas+and+CCKomas%3A+Recent+Advances&rft.au=Jensen%2C+R+T&rft.aulast=Jensen&rft.aufirst=R&rft.date=2006-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Benzon+Symposia%3A+The+New+Biology+of+the+Gastrin-Cholecystokinin+Family+of+Hormones&rft.issn=&rft_id=info:doi/ L2 - http://www.benzon-symposia.dk/sites/abstract53.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Predictors of Outcome in a Multicentered Randomized Controlled Trial of Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy T2 - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AN - 40370588; 4425038 JF - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AU - Shankaran, S Y1 - 2006/10/07/ PY - 2006 DA - 2006 Oct 07 KW - Clinical trials KW - Ischemia KW - Hypothermia KW - Hypoxia KW - Neonates KW - Encephalopathy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40370588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.atitle=Clinical+Predictors+of+Outcome+in+a+Multicentered+Randomized+Controlled+Trial+of+Whole+Body+Hypothermia+for+Neonatal+Hypoxic-Ischemic+Encephalopathy&rft.au=Shankaran%2C+S&rft.aulast=Shankaran&rft.aufirst=S&rft.date=2006-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/europaediatrics/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unraveling the Reactions of Nitric Oxide, Nitrite and Hemoglobin in Human Physiology and Therapeutics T2 - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AN - 40369152; 4425158 JF - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AU - Gladwin, M T Y1 - 2006/10/07/ PY - 2006 DA - 2006 Oct 07 KW - Nitrite KW - Physiology KW - Nitric oxide KW - Hemoglobin KW - Human physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40369152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.atitle=Unraveling+the+Reactions+of+Nitric+Oxide%2C+Nitrite+and+Hemoglobin+in+Human+Physiology+and+Therapeutics&rft.au=Gladwin%2C+M+T&rft.aulast=Gladwin&rft.aufirst=M&rft.date=2006-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/europaediatrics/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes AN - 19936468; 7079932 AB - Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor. Adoptive transfer of these transduced cells in 15 patients resulted in durable engraftment at levels exceeding 10% of peripheral blood lymphocytes for at least 2 months after the infusion. We observed high sustained levels of circulating, engineered cells at 1 year after infusion in two patients who both demonstrated objective regression of metastatic melanoma lesions. This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer. JF - Science (Washington) AU - Morgan, Richard A AU - Dudley, Mark E AU - Wunderlich, John R AU - Hughes, Marybeth S AU - Yang, James C AU - Sherry, Richard M AU - Royal, Richard E AU - Topalian, Suzanne L AU - Kammula, Udai S AU - Restifo, Nicholas P AU - Zheng, Zhili AU - Nahvi, Azam AU - De Vries, Christiaan R AU - Rogers-Freezer, Linda J AU - Mavroukakis, Sharon A AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA., SAR@mail.nih.gov Y1 - 2006/10/06/ PY - 2006 DA - 2006 Oct 06 SP - 126 EP - 129 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 314 IS - 5796 SN - 0036-8075, 0036-8075 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - T-cell receptor KW - Immunotherapy KW - double prime T-cell receptor KW - Peripheral blood KW - Tumors KW - Cancer KW - Melanoma KW - Metastases KW - Retrovirus KW - Genetic engineering KW - Adoptive transfer KW - Lymphocytes T KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19936468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Cancer+Regression+in+Patients+After+Transfer+of+Genetically+Engineered+Lymphocytes&rft.au=Morgan%2C+Richard+A%3BDudley%2C+Mark+E%3BWunderlich%2C+John+R%3BHughes%2C+Marybeth+S%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BRoyal%2C+Richard+E%3BTopalian%2C+Suzanne+L%3BKammula%2C+Udai+S%3BRestifo%2C+Nicholas+P%3BZheng%2C+Zhili%3BNahvi%2C+Azam%3BDe+Vries%2C+Christiaan+R%3BRogers-Freezer%2C+Linda+J%3BMavroukakis%2C+Sharon+A%3BRosenberg%2C+Steven+A&rft.aulast=Morgan&rft.aufirst=Richard&rft.date=2006-10-06&rft.volume=314&rft.issue=5796&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1129003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; T-cell receptor; Retrovirus; double prime T-cell receptor; Immunotherapy; Genetic engineering; Lymphocytes T; Adoptive transfer; Peripheral blood; Tumors; Cancer; Melanoma DO - http://dx.doi.org/10.1126/science.1129003 ER - TY - JOUR T1 - Menopausal hormone therapy and ovarian cancer risk in the National Institutes of Health-AARP Diet and Health Study Cohort. AN - 68928612; 17018786 AB - Recent studies offer conflicting data on risks of ovarian cancer in users of menopausal hormone therapy. Some findings of increased risks associated with unopposed estrogen use are based on older studies of women with intact uteri, and small sample size and incomplete exposure information have limited the data on estrogen plus progestin associations. The National Institutes of Health-AARP Diet and Health Study Cohort included 97,638 women aged 50-71 years at baseline who completed two questionnaires (1995-1996 and 1996-1997). We identified 214 incident ovarian cancers among these women through the year 2000 using data from state cancer registries and mortality indexes. We estimated relative risks (RRs) of ovarian cancer for detailed hormone therapy exposures using multivariable proportional hazards regression models. All statistical tests were two-sided. Use of unopposed estrogen for fewer than 10 years was not associated with ovarian cancer. Compared with use of no hormone therapy, use of unopposed estrogen for 10 or more years was statistically significantly associated with ovarian cancer among all women (RR = 1.89, 95% confidence interval [CI] = 1.22 to 2.95; P = .004; 56 versus 72 ovarian cancers per 100,000 person-years, respectively) and, albeit not statistically significantly, among women with hysterectomy (n = 19,359, RR = 1.70, 95% CI = 0.87 to 3.31; P = .06). Among the 73,483 women with intact uteri, 51,698 had used no hormone therapy or only estrogen plus progestin. Compared with no hormone therapy use, 5 or more years of use of sequential (progestin for or = 15 days per cycle; RR = 1.82, 95% CI = 1.03 to 3.23; P = .02; 49 versus 66 per 100,000 person-years) estrogen plus progestin regimens were statistically significantly associated with ovarian cancer. Long durations of use of unopposed estrogen and of estrogen plus progestin, especially sequential regimens, are associated with increased ovarian cancer risk. These data expand the range of possible risks associated with menopausal hormone therapy. JF - Journal of the National Cancer Institute AU - Lacey, James V AU - Brinton, Louise A AU - Leitzmann, Michael F AU - Mouw, Traci AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Hartge, Patricia AD - Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MDUSA. jimlacey@nih.gov Y1 - 2006/10/04/ PY - 2006 DA - 2006 Oct 04 SP - 1397 EP - 1405 VL - 98 IS - 19 KW - Estrogens KW - 0 KW - Progestins KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Aged KW - Progestins -- administration & dosage KW - Estrogens -- administration & dosage KW - Risk Assessment KW - Multivariate Analysis KW - Prospective Studies KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Proportional Hazards Models KW - Ovarian Neoplasms -- mortality KW - Estrogen Replacement Therapy -- adverse effects KW - Estrogen Replacement Therapy -- methods KW - Ovarian Neoplasms -- chemically induced KW - Menopause KW - Ovarian Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Menopausal+hormone+therapy+and+ovarian+cancer+risk+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Study+Cohort.&rft.au=Lacey%2C+James+V%3BBrinton%2C+Louise+A%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BHartge%2C+Patricia&rft.aulast=Lacey&rft.aufirst=James&rft.date=2006-10-04&rft.volume=98&rft.issue=19&rft.spage=1397&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-10 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide After Breast Cancer: an International Population-Based Study of 723 810 Women AN - 19358879; 7124595 AB - Few studies have examined long-term suicide risk among breast cancer survivors, and there are no data for women in the United States. We quantified suicide risk through 2002 among 723 810 1-year breast cancer survivors diagnosed between January 1, 1953, and December 31, 2001, and reported to 16 population-based cancer registries in the United States and Scandinavia. Among breast cancer survivors, we calculated standardized mortality ratios (SMRs) and excess absolute risks (EARs) compared with the general population, and the probability of suicide. We used Poisson regression likelihood ratio tests to assess heterogeneity in SMRs; all statistical tests were two-sided, with a .05 cutoff for statistical significance. In total 836 breast cancer patients committed suicide (SMR = 1.37, 95% confidence interval [CI] = 1.28 to 1.47; EAR = 4.1 per 100 000 person-years). Although SMRs ranged from 1.25 to 1.53 among registries, with 245 deaths among the sample of US women (SMR = 1.49, 95% CI = 1.32 to 1.70), differences among registries were not statistically significant (P for heterogeneity = .19). Risk was elevated throughout follow-up, including for 25 or more years after diagnosis (SMR = 1.35, 95% CI = 0.82 to 2.12), and was highest among black women (SMR = 2.88, 95% CI = 1.44 to 5.17) (P for heterogeneity = .06). Risk increased with increasing stage of breast cancer (P for heterogeneity = .08) and remained elevated among women diagnosed between 1990 and 2001 (SMR = 1.36, 95% CI = 1.18 to 1.57). The cumulative probability of suicide was 0.20% 30 years after breast cancer diagnosis. JF - Journal of the National Cancer Institute AU - Schairer, Catherine AU - Brown, Linda Morris AU - Chen, Bingshu E AU - Howard, Regan AU - Lynch, Charles F AU - Hall, Per AU - Storm, Hans AU - Pukkala, Eero AU - Anderson, Aage AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossaa, Sophie D AU - Ganz, Patricia A AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2006/10/04/ PY - 2006 DA - 2006 Oct 04 SP - 1416 EP - 1419 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 19 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Probability KW - USA KW - Breast cancer KW - Females KW - suicide KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19358879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Suicide+After+Breast+Cancer%3A+an+International+Population-Based+Study+of+723+810+Women&rft.au=Schairer%2C+Catherine%3BBrown%2C+Linda+Morris%3BChen%2C+Bingshu+E%3BHoward%2C+Regan%3BLynch%2C+Charles+F%3BHall%2C+Per%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BAnderson%2C+Aage%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossaa%2C+Sophie+D%3BGanz%2C+Patricia+A%3BTravis%2C+Lois+B&rft.aulast=Schairer&rft.aufirst=Catherine&rft.date=2006-10-04&rft.volume=98&rft.issue=19&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Probability; Mortality; Breast cancer; Females; suicide; USA ER - TY - JOUR T1 - Mathematical modeling of tumor therapy with oncolytic viruses: effects of parametric heterogeneity on cell dynamics. AN - 68987094; 17018145 AB - One of the mechanisms that ensure cancer robustness is tumor heterogeneity, and its effects on tumor cells dynamics have to be taken into account when studying cancer progression. There is no unifying theoretical framework in mathematical modeling of carcinogenesis that would account for parametric heterogeneity. Here we formulate a modeling approach that naturally takes stock of inherent cancer cell heterogeneity and illustrate it with a model of interaction between a tumor and an oncolytic virus. We show that several phenomena that are absent in homogeneous models, such as cancer recurrence, tumor dormancy, and others, appear in heterogeneous setting. We also demonstrate that, within the applied modeling framework, to overcome the adverse effect of tumor cell heterogeneity on the outcome of cancer treatment, a heterogeneous population of an oncolytic virus must be used. Heterogeneity in parameters of the model, such as tumor cell susceptibility to virus infection and the ability of an oncolytic virus to infect tumor cells, can lead to complex, irregular evolution of the tumor. Thus, quasi-chaotic behavior of the tumor-virus system can be caused not only by random perturbations but also by the heterogeneity of the tumor and the virus. The modeling approach described here reveals the importance of tumor cell and virus heterogeneity for the outcome of cancer therapy. It should be straightforward to apply these techniques to mathematical modeling of other types of anticancer therapy. Leonid Hanin (nominated by Arcady Mushegian), Natalia Komarova (nominated by Orly Alter), and David Krakauer. JF - Biology direct AU - Karev, Georgy P AU - Novozhilov, Artem S AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. karev@ncbi.nlm.nih.gov Y1 - 2006/10/03/ PY - 2006 DA - 2006 Oct 03 SP - 30 VL - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68987094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+direct&rft.atitle=Mathematical+modeling+of+tumor+therapy+with+oncolytic+viruses%3A+effects+of+parametric+heterogeneity+on+cell+dynamics.&rft.au=Karev%2C+Georgy+P%3BNovozhilov%2C+Artem+S%3BKoonin%2C+Eugene+V&rft.aulast=Karev&rft.aufirst=Georgy&rft.date=2006-10-03&rft.volume=1&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Biology+direct&rft.issn=1745-6150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2006-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Theor Popul Biol. 1999 Dec;56(3):325-35 [10607525] Nat Med. 1998 Dec;4(12):1341-2 [9846551] Nat Med. 2000 Aug;6(8):879-85 [10932224] J Clin Oncol. 2001 Jan 15;19(2):289-98 [11208818] Cancer Res. 2001 Apr 15;61(8):3501-7 [11309314] Cancer Genet Cytogenet. 2001 Jun;127(2):148-54 [11425455] Hum Gene Ther. 2001 Jul 1;12(10):1323-32 [11440625] Math Biosci. 2002 May-Jun;177-178:73-83 [11965249] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13085-9 [12351679] Cancer Gene Ther. 2002 Dec;9(12):979-86 [12522437] Biochim Biophys Acta. 2003 Aug 22;1622(3):169-78 [12928113] Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S157-60 [14508094] Mol Cancer Ther. 2003 Sep;2(9):919-27 [14555711] Cancer Res. 2003 Oct 1;63(19):6212-20 [14559806] Nature. 2003 Nov 13;426(6963):125 [14614483] J Neurooncol. 2003 Dec;65(3):203-26 [14682372] Curr Opin Mol Ther. 2003 Dec;5(6):618-24 [14755888] Nat Rev Cancer. 2004 Mar;4(3):197-205 [14993901] Nat Rev Cancer. 2004 Mar;4(3):227-35 [14993904] Curr Opin Oncol. 2005 Jan;17(1):39-43 [15608511] J Math Biol. 2005 Jul;51(1):37-74 [15772825] Cancer Gene Ther. 2005 Sep;12(9):725-36 [15818382] J Clin Invest. 2005 Jul;115(7):1903-12 [15937544] J Math Biol. 2005 Aug;51(2):123-43 [16012804] Semin Cancer Biol. 2005 Dec;15(6):474-83 [16043360] J Theor Biol. 2006 Feb 21;238(4):841-62 [16153659] Nat Rev Cancer. 2005 Dec;5(12):965-76 [16294217] Curr Gene Ther. 2005 Dec;5(6):595-605 [16457649] Science. 2006 Mar 24;311(5768):1780-4 [16556847] Nat Genet. 2006 Apr;38(4):468-73 [16565718] Cancer Gene Ther. 2006 Nov;13(11):975-92 [16604059] Cancer Res. 1986 May;46(5):2203-7 [3516380] Invasion Metastasis. 1987;7(4):217-29 [3667144] Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1727-33 [526911] Cancer Res. 1984 Jun;44(6):2259-65 [6372991] Cancer Treat Rep. 1984 Jan;68(1):43-61 [6692436] Science. 1984 Jun 1;224(4652):998-1001 [6719130] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Math Biosci. 1995 Jul-Aug;128(1-2):25-40 [7606137] J Theor Biol. 1995 Oct 21;176(4):447-55 [8551743] Mol Med Today. 1996 Dec;2(12):519-27 [9015793] Int Rev Cytol. 1998;177:1-56 [9378615] Cancer Res. 2000 Jan 1;60(1):114-20 [10646862] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. AN - 68925080; 17021379 AB - Amyloid fibrils characterized as highly intractable thread-like species are associated with many neurodegenerative diseases. Although neither the mechanism of amyloid formation nor the origin of amyloid toxicity is currently completely understood, the detailed three-dimensional atomic structures of the yeast protein Sup35 and Abeta amyloid protein determined by recent experiments provide the first and important step towards the comprehension of the pathogenesis and aggregation mechanisms of amyloid diseases. By analyzing these two amyloid peptides which have available crystal structures and other amyloid sequences with proposed structures using computational simulations, we delineate three common features in amyloid organizations and amyloid structures. These could contribute to an improved understanding of the molecular mechanism of amyloid formation, the nature of the aggregation driving forces that stabilize these structures and the development of potential therapeutic agents against amyloid diseases. JF - Physical biology AU - Zheng, Jie AU - Ma, Buyong AU - Nussinov, Ruth AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2006/10/03/ PY - 2006 DA - 2006 Oct 03 SP - P1 EP - P4 VL - 3 IS - 3 KW - Amyloid KW - 0 KW - Peptide Termination Factors KW - Prions KW - SUP35 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - Index Medicus KW - Prions -- chemistry KW - Protein Structure, Secondary KW - Amino Acid Motifs KW - Models, Molecular KW - Humans KW - Crystallography, X-Ray KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Protein Structure, Tertiary KW - Protein Conformation KW - Amyloid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+biology&rft.atitle=Consensus+features+in+amyloid+fibrils%3A+sheet-sheet+recognition+via+a+%28polar+or+nonpolar%29+zipper+structure.&rft.au=Zheng%2C+Jie%3BMa%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2006-10-03&rft.volume=3&rft.issue=3&rft.spage=P1&rft.isbn=&rft.btitle=&rft.title=Physical+biology&rft.issn=1478-3975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alterations in CNS activity induced by botulinum toxin treatment in spasmodic dysphonia: an H215O PET study. AN - 85398735; pmid-17077220 AB - Speech-related changes in regional cerebral blood flow (rCBF) were measured using H(2)(15)O positron-emission tomography in 9 adults with adductor spasmodic dysphonia (ADSD) before and after botulinum toxin (BTX) injection and 10 age- and gender-matched volunteers without neurological disorders. Scans were acquired at rest and during production of continuous narrative speech and whispered speech. Speech was recorded during scan acquisition for offline quantification of voice breaks, pitch breaks, and percentage aperiodicity to assess correlations between treatment-related changes in rCBF and clinical improvement. Results demonstrated that speech-related responses in heteromodal sensory areas were significantly reduced in persons with ADSD, compared with volunteers, before the administration of BTX. Three to 4 weeks after BTX injection, speech-related responses were significantly augmented in these regions and in left hemisphere motor areas commonly associated with oral-laryngeal motor control. This pattern of responses was most strongly correlated with the objective measures of clinical improvement (decreases in the frequency of voice breaks, pitch breaks, and percentage aperiodicity). These data suggest a pathophysiological model for ADSD in which BTX treatment results in more efficient cortical processing of sensory information, making this information available to motor areas that use it to more effectively regulate laryngeal movements. JF - Journal of speech, language, and hearing research : JSLHR AU - Ali, S Omar AU - Thomassen, Michael AU - Schulz, Geralyn M AU - Hosey, Lara A AU - Varga, Mary AU - Ludlow, Christy L AU - Braun, Allen R AD - Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 8S235A, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1127 EP - 1146 VL - 49 IS - 5 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Anti-Dyskinesia Agents: pharmacology KW - Anti-Dyskinesia Agents: therapeutic use KW - *Botulinum Toxins: pharmacology KW - Botulinum Toxins: therapeutic use KW - *Brain: blood supply KW - Brain: drug effects KW - Brain Mapping KW - Case-Control Studies KW - Female KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - *Positron-Emission Tomography: methods KW - Regional Blood Flow: drug effects KW - *Speech: drug effects KW - Speech Production Measurement KW - *Voice Disorders: drug therapy KW - Voice Disorders: physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Alterations+in+CNS+activity+induced+by+botulinum+toxin+treatment+in+spasmodic+dysphonia%3A+an+H215O+PET+study.&rft.au=Ali%2C+S+Omar%3BThomassen%2C+Michael%3BSchulz%2C+Geralyn+M%3BHosey%2C+Lara+A%3BVarga%2C+Mary%3BLudlow%2C+Christy+L%3BBraun%2C+Allen+R&rft.aulast=Ali&rft.aufirst=S&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Patterns of care for adjuvant therapy in a random population-based sample of patients diagnosed with colorectal cancer. AN - 85398154; pmid-17032196 AB - Over the past decade, clinical trials have proved the efficacy of treatments for colorectal cancer (CRC). This study tracks dissemination of these treatments for patients diagnosed with stage II and III disease and compares risk of death for those who received guideline therapy to those who did not.We conducted a stratified randomly sampled, population-based study of CRC treatment trends in the United States. Multivariate models were used to explore patient characteristics associated with receipt of treatments. We pooled data with a previous study-patients diagnosed in 1987-1991 and 1995. Cox proportional hazards models were used to assess observed cause-specific and all-cause mortality.In 2000, guideline therapy receipt decreased among stage III rectal cancer patients, but increased for stage III colon and stage II rectal cancer patients. As age increased, likelihood of receiving guideline treatment decreased (p < 0.0001). Overall, race/ethnicity was significantly associated with guideline therapy (p = 0.04). Rectal patients were less likely to have received guideline treatment. Consistent with randomized clinical trial findings, all-cause mortality was lower in patients who received guideline therapy, regardless of Charlson comorbidity score.Mortality was decreased in patients receiving guideline therapy. Although, rates of guideline-concordant therapy are low in community clinical practice, they are apparently increasing. Newer treatment (oxaliplatin, capecitabine) started to disseminate in 2000. Racial disparities, present in 1995, were not detected in 2000. Age disparities remain despite no evidence of greater chemotherapy-induced toxicity in the elderly. More equitable receipt of cancer treatment to all segments of the community will help to reduce mortality. JF - The American journal of gastroenterology AU - Cronin, Deirdre P AU - Harlan, Linda C AU - Potosky, Arnold L AU - Clegg, Limin X AU - Stevens, Jennifer L AU - Mooney, Margaret M AD - Surveillance Research Program, DCCPS, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2308 EP - 2318 VL - 101 IS - 10 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Antineoplastic Agents: therapeutic use KW - *Colorectal Neoplasms: drug therapy KW - Colorectal Neoplasms: mortality KW - Colorectal Neoplasms: pathology KW - Female KW - *Guideline Adherence: statistics & numerical data KW - Humans KW - Male KW - Middle Aged KW - Neoplasm Staging KW - *Physician's Practice Patterns: statistics & numerical data KW - *Practice Guidelines as Topic KW - *SEER Program KW - United States: epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Patterns+of+care+for+adjuvant+therapy+in+a+random+population-based+sample+of+patients+diagnosed+with+colorectal+cancer.&rft.au=Cronin%2C+Deirdre+P%3BHarlan%2C+Linda+C%3BPotosky%2C+Arnold+L%3BClegg%2C+Limin+X%3BStevens%2C+Jennifer+L%3BMooney%2C+Margaret+M&rft.aulast=Cronin&rft.aufirst=Deirdre&rft.date=2006-10-01&rft.volume=101&rft.issue=10&rft.spage=2308&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Direct costs of managing Parkinson's disease in India: concerns in a developing country. AN - 85396823; pmid-16874759 AB - Medicines and surgical interventions improve the quality of life of Parkinson's disease (PD) patients. These are still expensive options and are unaffordable to those living in developing countries. Managing PD in Indians who have a low annual gross national income (GNI; 450-540 US dollars) and for whom only a few (3%) have health insurance is a challenge. We interviewed 175 consecutive PD patients regarding health insurance and money spent for treatment. The annual income of nearly half the patients was less than rupees 50,000 (1,148.63 US dollars). Patients in this study spend nearly 16% to 41.7% of the average Indian GNI to buy medicines. Costs of treating PD in India are lower than those in developed nations but are still out of reach for most Indian patients. JF - Movement disorders : official journal of the Movement Disorder Society AU - Ragothaman, Mona AU - Govindappa, Shyla T AU - Rattihalli, Rohini AU - Subbakrishna, Dodaballapur K AU - Muthane, Uday B AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1755 EP - 1758 VL - 21 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Ambulatory Care: economics KW - Antiparkinson Agents: economics KW - Antiparkinson Agents: therapeutic use KW - Cross-Cultural Comparison KW - *Developing Countries KW - Drug Costs: statistics & numerical data KW - Female KW - Financing, Personal: economics KW - Health Care Costs: statistics & numerical data KW - *Health Expenditures: statistics & numerical data KW - Humans KW - Income: statistics & numerical data KW - India KW - Insurance, Health: economics KW - Male KW - Mathematical Computing KW - Middle Aged KW - Parkinson Disease: drug therapy KW - *Parkinson Disease: economics KW - Prospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Direct+costs+of+managing+Parkinson%27s+disease+in+India%3A+concerns+in+a+developing+country.&rft.au=Ragothaman%2C+Mona%3BGovindappa%2C+Shyla+T%3BRattihalli%2C+Rohini%3BSubbakrishna%2C+Dodaballapur+K%3BMuthane%2C+Uday+B&rft.aulast=Ragothaman&rft.aufirst=Mona&rft.date=2006-10-01&rft.volume=21&rft.issue=10&rft.spage=1755&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance: comparison of horizontal and 6 degrees head-down bed rest. AN - 85396737; pmid-17165393 AB - This study examined the effect of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance. Each of 7 volunteers were maintained for 3 days of head-down and horizontal bed rest in a counter-balanced design. Assessment measures were polysomnographic recordings on the first night and performance on psychophysiological tasks on the second day involving subjective and objective vigilance, P300, simple reaction time tasks, and dual performance tasks. No clear difference in sleep structure was observed between the head-down and horizontal conditions, except for a slight decrease in Stage 4 for head-down. Both subjective and objective daytime vigilance, P300, and the simple RT task showed no statistical difference, although tracking performance on the dual task showed deterioration at 10:00 for the head-down condition. These results suggest that nocturnal sleep, daytime vigilance, and psychophysiological functions were not disturbed in head-down sleep conditions, although there was a mild deterioration of higher attentional function in the morning. JF - Perceptual and motor skills AU - Komada, Yoko AU - Inoue, Yuichi AU - Mizuno, Koh AU - Tanaka, Hideki AU - Mishima, Kazuo AU - Sato, Hidetomo AU - Shirakawa, Shuichiro AD - Japan Somnology Center, Neuropsychiatric Research Institute, Geriatric Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. yoko@ncnp-k.go.jp Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 307 EP - 317 VL - 103 IS - 2 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Attention: physiology KW - Bed Rest KW - Cerebral Cortex: physiology KW - Circadian Rhythm: physiology KW - Event-Related Potentials, P300: physiology KW - Fourier Analysis KW - *Head-Down Tilt: physiology KW - Humans KW - Kinesthesis: physiology KW - Male KW - Polysomnography KW - Posture: physiology KW - *Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Signal Processing, Computer-Assisted KW - *Sleep Stages: physiology KW - *Wakefulness: physiology KW - *Weightlessness Simulation: psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Effects+of+acute+simulated+microgravity+on+nocturnal+sleep%2C+daytime+vigilance%2C+and+psychomotor+performance%3A+comparison+of+horizontal+and+6+degrees+head-down+bed+rest.&rft.au=Komada%2C+Yoko%3BInoue%2C+Yuichi%3BMizuno%2C+Koh%3BTanaka%2C+Hideki%3BMishima%2C+Kazuo%3BSato%2C+Hidetomo%3BShirakawa%2C+Shuichiro&rft.aulast=Komada&rft.aufirst=Yoko&rft.date=2006-10-01&rft.volume=103&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. AN - 85396480; pmid-16795004 AB - Lewy bodies, the pathological hallmark of Parkinson's disease (PD), consist largely of alpha-synuclein, a 14.5-kDa presynaptic neuronal protein implicated in familial PD. An increased copy number and elevated expression of wild-type alpha-synuclein (SNCA) has been shown to cause early-onset familial PD. However, it is not clear whether increased alpha-synuclein expression also plays a role in the pathogenesis of sporadic disease. In the current study, we analyzed the levels of SNCA-mRNA in affected brains of sporadic PD patients. We compared the levels of steady state SNCA-mRNA in 7 sporadic PD brain samples and 7 normal controls using real-time polymerase chain reaction of RNA extracted from mid-brain tissue, including the substantia nigra. Despite that there is neuronal loss in the substantia nigra of PD brains, overall the SNCA-mRNA levels were increased in PD brains an average of nearly fourfold over normal control mid-brain, although there was much greater variability in samples from PD patients compared to controls. Frontal cortex samples from selected individuals were also analyzed. SNCA-mRNA levels were not significantly changed in PD frontal cortex compared to controls. These results suggest that elevated expression levels of SNCA-mRNA are found in the affected regions of PD brain and support the hypothesis that increases in alpha-synuclein expression is associated, among other factors, with the development of sporadic PD. JF - Movement disorders : official journal of the Movement Disorder Society AU - Chiba-Falek, Ornit AU - Lopez, Grisel J AU - Nussbaum, Robert L AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1703 EP - 1708 VL - 21 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Female KW - Gene Expression: physiology KW - Genetic Predisposition to Disease: genetics KW - Humans KW - Male KW - Mesencephalon: metabolism KW - Parkinson Disease: diagnosis KW - *Parkinson Disease: genetics KW - *RNA, Messenger: genetics KW - Reference Values KW - Substantia Nigra: metabolism KW - *alpha-Synuclein: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Levels+of+alpha-synuclein+mRNA+in+sporadic+Parkinson+disease+patients.&rft.au=Chiba-Falek%2C+Ornit%3BLopez%2C+Grisel+J%3BNussbaum%2C+Robert+L&rft.aulast=Chiba-Falek&rft.aufirst=Ornit&rft.date=2006-10-01&rft.volume=21&rft.issue=10&rft.spage=1703&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Mov Disord. 2007 May 15;22(7):1057-9; author reply 1057[17373725] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Tiling DNA microarrays for fly genome cartography AN - 762279252; 13696812 AB - Full-genome tiling arrays provide powerful biological evidence to support gene predictions and suggest the need for new and improved annotations. New studies using tiling arrays of the Drosophila melanogaster genome show that 85% of the fly genome is transcribed and processed into mature transcripts, representing 30% of the fly genome. JF - Nature Genetics AU - Oliver, Brian AD - Brian Oliver is in the Laboratory of Cellular and Developmental Biology, US National Institutes of Health, Bethesda, Maryland 20892, USA. oliver[AT]helix.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1101 EP - 1102 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 38 IS - 10 SN - 1061-4036, 1061-4036 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Drosophila melanogaster KW - DNA microarrays KW - W 30910:Imaging KW - G 07810:Insects KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762279252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Tiling+DNA+microarrays+for+fly+genome+cartography&rft.au=Oliver%2C+Brian&rft.aulast=Oliver&rft.aufirst=Brian&rft.date=2006-10-01&rft.volume=38&rft.issue=10&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/10.1038%2Fng1006-1101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Genomes; DNA microarrays; Drosophila melanogaster DO - http://dx.doi.org/10.1038/ng1006-1101 ER - TY - JOUR T1 - Immunotoxins in the treatment of hematologic malignancies. AN - 69017725; 17073592 AB - Immunotoxins, composed of protein toxins connected to cell binding ligands including monoclonal antibodies and growth factors, have been developed for several decades to target hematologic malignancies. Protein toxins from either plants or bacteria are extremely potent based on their enzymatic inhibition of protein synthesis and induction of apoptosis. Plant toxins, particularly ricin, are useful for chemically conjugating to monoclonal antibodies, and have shown clinical activity in several types of lymphoma and leukemia. Their dose is generally limited by vascular leak syndrome. Bacterial toxins have been used to produce single chain fusions with either growth factors or recombinant antibody fragments. These agents are smaller in size (55-65 kDa) and exit the bloodstream much more rapidly than the chemical conjugates, and generally do not cause severe vascular leak syndrome. The only approved drug containing a protein toxin is denileukin diftitox, a fusion of human interleukin 2 with truncated diphtheria toxin. Denileukin diftitox has shown efficacy in cutaneous T-cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. Recombinant immunotoxin BL22 is an anti-CD22 Fv fragment fused to truncated Pseudomonas exotoxin; it induces complete remissions in a high percentage of patients with chemoresistant hairy cell leukemia. The anti-CD25 recombinant immunotoxin LMB-2 is active in several CD25+ hematologic malignancies. Several other recombinant immunotoxins are undergoing preclinical development for other target antigens expressed on hematologic malignancies. JF - Current drug targets AU - Kreitman, Robert J AU - Pastan, Ira AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124b, Bethesda, MD 20892-4255, USA. kreitmar@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1301 EP - 1311 VL - 7 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Immunotoxins KW - Index Medicus KW - Animals KW - Humans KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69017725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets&rft.atitle=Immunotoxins+in+the+treatment+of+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=7&rft.issue=10&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets&rft.issn=1873-5592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. AN - 69012575; 17049983 AB - Studies of the role of vasopressin (Avp) in mediating the effects of ethanol have focused on Avp's role in altering kidney function via its action through the vasopressin 2 receptor. However, alcohol consumption also has central effects that are poorly understood. There is evidence that Avp may mediate ethanol consumption as well as some of ethanol's behavioral effects. Centrally only two Avp receptor subtypes are expressed: the 1a receptor (Avpr1a) and the 1b receptor (Avpr1b). To determine the extent to which these receptors mediate the behavioral effects of alcohol, we used mice with targeted disruptions of either their Avpr1a or Avpr1b gene. We examined the effects of genotype on the acute intoxicating effects of ethanol as well as on voluntary ethanol consumption. Surprisingly, our findings indicate that there is no interaction between either the Avpr1a or Avpr1b and ethanol on motor coordination, hypothermia, mood, or voluntary ethanol consumption. JF - Neuropeptides AU - Caldwell, Heather K AU - Stewart, John AU - Wiedholz, Lisa M AU - Millstein, Rachel A AU - Iacangelo, Anna AU - Holmes, Andrew AU - Young, W Scott AU - Wersinger, Scott R AD - Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA. heathercaldwell@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 325 EP - 337 VL - 40 IS - 5 SN - 0143-4179, 0143-4179 KW - Hypnotics and Sedatives KW - 0 KW - Receptors, Vasopressin KW - Index Medicus KW - Animals KW - Anxiety -- psychology KW - Mice KW - Hypnotics and Sedatives -- pharmacology KW - Postural Balance -- drug effects KW - Mice, Knockout KW - Body Temperature Regulation -- drug effects KW - Swimming -- psychology KW - Reflex -- drug effects KW - Alcohol Drinking -- psychology KW - Mice, Inbred C57BL KW - Motor Activity -- drug effects KW - Alcohol Drinking -- genetics KW - Female KW - Male KW - Alcoholic Intoxication -- physiopathology KW - Receptors, Vasopressin -- physiology KW - Receptors, Vasopressin -- genetics KW - Alcoholic Intoxication -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69012575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropeptides&rft.atitle=The+acute+intoxicating+effects+of+ethanol+are+not+dependent+on+the+vasopressin+1a+or+1b+receptors.&rft.au=Caldwell%2C+Heather+K%3BStewart%2C+John%3BWiedholz%2C+Lisa+M%3BMillstein%2C+Rachel+A%3BIacangelo%2C+Anna%3BHolmes%2C+Andrew%3BYoung%2C+W+Scott%3BWersinger%2C+Scott+R&rft.aulast=Caldwell&rft.aufirst=Heather&rft.date=2006-10-01&rft.volume=40&rft.issue=5&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Neuropeptides&rft.issn=01434179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic basis of cancer of the kidney. AN - 68968579; 17045083 AB - Kidney cancer is not a single disease. It is made up of a number of different types of cancer that occur in the kidney, each with a different histologic type, having a different clinical course, responding differently to therapy and caused by a different gene. The identification of families with a predisposition to the development of renal neoplasms, including von Hippel-Lindau (VHL), hereditary papillary renal carcinoma (HPRC), Birt-Hogg-Dubé (BHD), and hereditary leiomyomatosis and renal cell cancer (HLRCC), has made possible the identification of the different genes for these cancers. The genetic basis for each of these has been identified with current investigation focusing on the mechanisms of carcinogenesis. The elucidation of molecular pathogenesis in these familial forms of kidney cancer should provide the opportunity to determine successful approaches for novel therapeutic agents. JF - Seminars in oncology AU - Sudarshan, Sunil AU - Linehan, W Marston AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1107, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 544 EP - 551 VL - 33 IS - 5 SN - 0093-7754, 0093-7754 KW - Index Medicus KW - Syndrome KW - Humans KW - Kidney Neoplasms -- genetics KW - von Hippel-Lindau Disease -- genetics KW - Genetic Predisposition to Disease KW - Carcinoma, Renal Cell -- genetics KW - Carcinoma, Papillary -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Genetic+basis+of+cancer+of+the+kidney.&rft.au=Sudarshan%2C+Sunil%3BLinehan%2C+W+Marston&rft.aulast=Sudarshan&rft.aufirst=Sunil&rft.date=2006-10-01&rft.volume=33&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: effects in laboratory rat models relating to addiction. AN - 68967101; 16901516 AB - Slow-onset, long-lasting dopamine reuptake blockers with reduced abuse potential have been suggested as maintenance therapies for cocaine addiction. We have synthesized a series of 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake inhibitors as candidates for such maintenance pharmacotherapy. The initial lead compound, the N,N-dimethyl analogue 30,640 was then subjected to testing in addiction-relevant animal models. Compound 30,640 (2 mg/kg i.p.) produced a pronounced slow-onset, long-lasting increase (300-400%) in extracellular nucleus accumbens dopamine levels, as measured by in vivo brain microdialysis in awake laboratory rats. Slow-onset, long-lasting decreases (40-80%) in the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid, and the serotonin metabolite 5-hydroxyindoleacetic acid were also seen. Compound 30,640 (3 or 5 mg/kg i.p.) also produced a significant (approximately 30%) slow-onset, long-lasting enhancement of electrical brain-stimulation reward, which was additive with that of cocaine (5 mg/kg i.p.). When given to cocaine-administering rats, 30,640 (2.5, 3, 5, or 10 mg/kg i.p.) significantly inhibited (30-60%) intravenous cocaine self-administration, with a pronounced long-lasting profile. In sum, 30,640 showed cocaine-like effects, but with a marked slow-onset, long-lasting profile. We conclude that the prodrug strategy employed in the design of 30,640 achieved its goal. We suggest that such compounds may be useful as maintenance pharmacotherapies for psychostimulant addiction. JF - Neuropharmacology AU - Gardner, Eliot L AU - Liu, Xinhe AU - Paredes, William AU - Giordano, Anthony AU - Spector, Jordan AU - Lepore, Marino AU - Wu, Kuo-Ming AU - Froimowitz, Mark AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Building C - Room 393, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. egardner@intra.nida.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 993 EP - 1003 VL - 51 IS - 5 SN - 0028-3908, 0028-3908 KW - Indans KW - 0 KW - Indenes KW - Neurotransmitter Uptake Inhibitors KW - compound 30,640 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Electric Stimulation -- methods KW - Nucleus Accumbens -- drug effects KW - Dose-Response Relationship, Drug KW - Hydroxyindoleacetic Acid -- metabolism KW - Disease Models, Animal KW - Dopamine -- metabolism KW - Homovanillic Acid -- metabolism KW - Behavior, Animal KW - Dialysis -- methods KW - Rats KW - Indenes -- therapeutic use KW - Rats, Sprague-Dawley KW - Self Administration -- methods KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Nucleus Accumbens -- metabolism KW - Indenes -- chemistry KW - Time Factors KW - Male KW - Indans -- therapeutic use KW - Indans -- chemistry KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Substance-Related Disorders -- etiology KW - Substance-Related Disorders -- drug therapy KW - Neurotransmitter Uptake Inhibitors -- therapeutic use KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68967101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=A+slow-onset%2C+long-duration+indanamine+monoamine+reuptake+inhibitor+as+a+potential+maintenance+pharmacotherapy+for+psychostimulant+abuse%3A+effects+in+laboratory+rat+models+relating+to+addiction.&rft.au=Gardner%2C+Eliot+L%3BLiu%2C+Xinhe%3BParedes%2C+William%3BGiordano%2C+Anthony%3BSpector%2C+Jordan%3BLepore%2C+Marino%3BWu%2C+Kuo-Ming%3BFroimowitz%2C+Mark&rft.aulast=Gardner&rft.aufirst=Eliot&rft.date=2006-10-01&rft.volume=51&rft.issue=5&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-12 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolism of furans in vitro: ipomeanine and 4-ipomeanol. AN - 68964556; 17040101 AB - Ipomeanine (IPN), 4-ipomeanol (4-IPO), 1-ipomeanol (1-IPO), and 1,4-ipomeadiol (DIOL) are toxic 3-substituted furans found in mold-damaged sweet potatoes. IPN and 4-IPO are the most toxic, but all produce pulmonary toxicity in cattle and rodents, and 4-IPO induces hepatotoxicity in humans. These furans require metabolic activation to elicit toxicity, but the limited information obtained from previous metabolism studies prompted us to initiate the investigation reported here. Our initial studies of 4-IPO metabolism by rat liver microsomes demonstrated that the oxidation of 4-IPO to IPN and reduction to DIOL occurred and that more IPN was metabolized to a reactive species than 4-IPO or DIOL. Incubation of IPN and Gly produced a 2'-pyrrolin-5'-one adduct establishing that IPN was metabolized to an enedial. N-Acetylcysteine reacted with the 5'-aldehyde of the enedial to give two 2',5'-dihydro-2'-hydroxyfurans stabilized by H bonding between the 2'-OH and 3'-keto group. Reaction of the enedial metabolite of IPN with one GSH gave several adducts including a pyrrole derived from the 1,2-addition of GSH to the 5'-aldehyde as well as two tricyclic 2'-pyrrolines derived from the 1,4-addition of GSH at the 4'-position. The identities of the pyrrole and 2'-pyrroline GSH adducts were confirmed by observation of structurally similar adducts from Cys conjugation with the enedial metabolite of IPN. Several minor adducts from the conjugation of the enedial metabolite of IPN with two GSH were also detected. Mono-GSH and bis-GSH adducts were derived from both the 1,2-and 1,4-addition of GSH to the enedial metabolite of 4-IPO in rat liver microsomal incubations of 4-IPO and GSH. Sequential oxidation of 4-IPO to IPN and then to the enedial metabolite followed by GSH conjugation also occurred in the 4-IPO incubations. The complex structures of the reaction products of the enedial with biological nucleophiles may explain why the many attempts to identify 4-IPO adducts to protein have not been successful. JF - Chemical research in toxicology AU - Chen, Ling-Jen AU - DeRose, Eugene F AU - Burka, Leo T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. ferguso2@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1320 EP - 1329 VL - 19 IS - 10 SN - 0893-228X, 0893-228X KW - Furans KW - 0 KW - Terpenes KW - 4-ipomeanol KW - 32954-58-8 KW - ipomeanine KW - 496-06-0 KW - NADP KW - 53-59-8 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Molecular Structure KW - Animals KW - Acetylation KW - Rats, Inbred F344 KW - Cysteine -- metabolism KW - Microsomes -- metabolism KW - Glycine -- metabolism KW - Glutathione -- metabolism KW - NADP -- metabolism KW - Methylation KW - Furans -- metabolism KW - Furans -- chemistry KW - Terpenes -- metabolism KW - Terpenes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68964556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Metabolism+of+furans+in+vitro%3A+ipomeanine+and+4-ipomeanol.&rft.au=Chen%2C+Ling-Jen%3BDeRose%2C+Eugene+F%3BBurka%2C+Leo+T&rft.aulast=Chen&rft.aufirst=Ling-Jen&rft.date=2006-10-01&rft.volume=19&rft.issue=10&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. AN - 68960383; 17041104 AB - Expression of the chemokine receptor CXCR4 by tumor cells promotes metastasis, possibly by activating prosurvival signals that render cancer cells resistant to immune attack. Inhibition of CXCR4 with a peptide antagonist, T22, blocks metastatic implantation of CXCR4-transduced B16 (CXCR4-luc-B16) melanoma cells in lung, but not the outgrowth of established metastases, raising the question of how T22 can best be used in a clinical setting. Herein, whereas the treatment of CXCR4-luc-B16 cells in vitro with the CXCR4 ligand CXCL12 did not reduce killing induced by cisplatin or cyclophosphamide, CXCL12 markedly reduced Fas-dependent killing by gp100-specific (pmel-1) CD8(+) T cells. T22 pretreatment restored sensitivity of CXCR4-luc-B16 cells to pmel-1 killing, even in the presence of CXCL12. Two immune-augmenting regimens were used in combination with T22 to treat experimental lung metastases. First, low-dose cyclophosphamide treatment (100 mg/kg) on day 5 in combination with T22 (days 4-7) yielded a approximately 70% reduction of B16 metastatic tumor burden in the lungs compared with cyclophosphamide treatment alone (P < 0.001). Furthermore, whereas anti-CTL antigen 4 (CTLA4) monoclonal antibody (mAb; or T22 treatment) alone had little effect on established B16 metastases, pretreatment with T22 (in combination with anti-CTLA4 mAb) resulted in a 50% reduction in lung tumor burden (P = 0.02). Thus, in vitro, CXCR4 antagonism with T22 renders B16 cells susceptible to killing by antigen-specific T cells. In vivo, T22 synergizes with cyclophosphamide or anti-CTLA4 mAb in the treatment of established lung metastases, suggesting a novel strategy for augmenting the efficacy of immunotherapy. JF - Molecular cancer therapeutics AU - Lee, Chih-Hung AU - Kakinuma, Takashi AU - Wang, Julia AU - Zhang, Hong AU - Palmer, Douglas C AU - Restifo, Nicholas P AU - Hwang, Sam T AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1908, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2592 EP - 2599 VL - 5 IS - 10 SN - 1535-7163, 1535-7163 KW - Antibodies, Monoclonal KW - 0 KW - CXCL12 protein, human KW - Chemokine CXCL12 KW - Chemokines, CXC KW - Cxcl12 protein, mouse KW - Peptides KW - Receptors, CXCR4 KW - T22 peptide KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Apoptosis KW - Humans KW - Immunotherapy KW - T-Lymphocytes, Cytotoxic -- immunology KW - B-Lymphocytes -- immunology KW - Mice KW - Neoplasm Transplantation KW - Chemokines, CXC -- pharmacology KW - Cytotoxicity, Immunologic KW - Mice, Inbred C57BL KW - Mice, SCID KW - Drug Synergism KW - Female KW - Melanoma, Experimental -- secondary KW - Peptides -- administration & dosage KW - Lung Neoplasms -- immunology KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- therapy KW - Receptors, CXCR4 -- antagonists & inhibitors KW - Antibodies, Monoclonal -- pharmacology KW - Peptides -- pharmacology KW - Antibodies, Monoclonal -- administration & dosage KW - Melanoma, Experimental -- immunology KW - Melanoma, Experimental -- therapy KW - Peptides -- therapeutic use KW - Receptors, CXCR4 -- immunology KW - Receptors, CXCR4 -- genetics KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68960383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Sensitization+of+B16+tumor+cells+with+a+CXCR4+antagonist+increases+the+efficacy+of+immunotherapy+for+established+lung+metastases.&rft.au=Lee%2C+Chih-Hung%3BKakinuma%2C+Takashi%3BWang%2C+Julia%3BZhang%2C+Hong%3BPalmer%2C+Douglas+C%3BRestifo%2C+Nicholas+P%3BHwang%2C+Sam+T&rft.aulast=Lee&rft.aufirst=Chih-Hung&rft.date=2006-10-01&rft.volume=5&rft.issue=10&rft.spage=2592&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-30 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat New Biol. 1973 Apr 4;242(118):148-9 [4512654] Exp Dermatol. 2004 Oct;13(10):613-20 [15447721] J Exp Med. 1977 Feb 1;145(2):455-9 [299883] Antimicrob Agents Chemother. 1992 Jun;36(6):1249-55 [1384424] Cancer Res. 1995 Jul 15;55(14):3149-57 [7541714] J Exp Med. 1995 Aug 1;182(2):459-65 [7543139] J Exp Med. 1997 Oct 20;186(8):1383-8 [9334378] J Exp Med. 1997 Oct 20;186(8):1389-93 [9334379] J Virol. 1999 Feb;73(2):1719-23 [9882387] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] Clin Cancer Res. 2005 Mar 1;11(5):1835-41 [15756007] Blood. 2005 Apr 1;105(7):2862-8 [15591121] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] Oncogene. 2005 Jun 23;24(27):4462-71 [15806155] J Dermatol Sci. 2005 Aug;39(2):105-12 [15899580] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Melanoma Res. 2005 Dec;15(6):543-8 [16314741] J Leukoc Biol. 2006 Apr;79(4):639-51 [16478915] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13513-8 [14595012] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14470-5 [10588729] Nature. 2001 Mar 1;410(6824):50-6 [11242036] J Exp Med. 2001 Aug 20;194(4):481-9 [11514604] J Exp Med. 2001 Sep 17;194(6):823-32 [11560997] J Immunother. 2001 Jul-Aug;24(4):363-73 [11565838] J Biol Chem. 2001 Nov 30;276(48):45098-105 [11571298] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] J Immunol. 2002 Nov 15;169(10):5546-54 [12421931] Cancer Res. 2002 Dec 15;62(24):7328-34 [12499276] Cancer Res. 2003 Jul 1;63(13):3833-9 [12839981] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] Nature. 2003 Sep 18;425(6955):307-11 [13679920] Cancer Res. 2003 Oct 15;63(20):6751-7 [14583470] J Exp Med. 2003 Nov 3;198(9):1337-47 [14581607] Eur J Immunol. 2004 Feb;34(2):336-44 [14768038] Vaccine. 2004 Apr 16;22(13-14):1700-8 [15068853] N Engl J Med. 2004 Apr 1;350(14):1461-3 [15070799] Nat Rev Cancer. 2004 Jul;4(7):540-50 [15229479] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 2004 Sep 20;200(6):771-82 [15381730] Immunology. 1975 May;28(5):939-42 [1132885] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents. AN - 68959143; 16871277 AB - The realization in the 1990s that allogeneic stem cell transplants (SCT) have a potentially curative graft-versus-leukemia (GVL) effect in addition to the antileukemic action of myeloablative conditioning regimens was a major stimulus for the development of reduced-intensity conditioning (RIC) regimens, aimed primarily at securing engraftment to provide the GVL effect, while minimizing regimen-related toxicity. It is now over 10 years since RIC regimens were heralded as a new direction in the field of SCT. Over the last decade much has been learned about the ways in which the conditioning regimen can be tailored to provide adequate immunosuppression, and modulated to deliver a chosen degree of antimalignant treatment. The huge literature of clinical data with RIC transplantation now permits us to more clearly define the success and limitations of the approach. This review examines the origins of RIC SCT, explores the degree to which the initial expectations and purpose of the approach have been realized, and outlines some ways forward for the field. JF - Leukemia AU - Barrett, A J AU - Savani, B N AD - Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda MD 20892-1202, USA. barrettj@nhlbi.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1661 EP - 1672 VL - 20 IS - 10 SN - 0887-6924, 0887-6924 KW - Index Medicus KW - Humans KW - Leukemia -- therapy KW - Hematopoietic Stem Cell Transplantation -- trends KW - Transplantation Conditioning -- trends KW - Graft vs Leukemia Effect UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68959143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Stem+cell+transplantation+with+reduced-intensity+conditioning+regimens%3A+a+review+of+ten+years+experience+with+new+transplant+concepts+and+new+therapeutic+agents.&rft.au=Barrett%2C+A+J%3BSavani%2C+B+N&rft.aulast=Barrett&rft.aufirst=A&rft.date=2006-10-01&rft.volume=20&rft.issue=10&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal smoking and testicular germ cell tumors. AN - 68952953; 17035387 AB - Testicular germ cell tumors (TGCT) are the most common cancer among men ages 15 to 35 years in the United States. The well-established TGCT risk factors cryptorchism, prior diagnosis of TGCT, and family history of testicular cancer indicate that exposures in early life and/or in the familial setting may be critical to determining risk. Previous reports of familial clustering of lung cancer in mothers and testicular cancers in sons suggest that passive smoking in childhood may be such an exposure. To clarify the relationship of passive smoking exposure to TGCT risk, data from 754 cases and 928 controls enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Data from 1,086 mothers of the cases and controls were also examined. Overall, there was no relationship between maternal [odds ratio (OR), 1.1; 95% confidence interval (95% CI), 0.9-1.3] or paternal smoking (OR, 1.0; 95% CI, 0.8-1.3) and TGCT risk. Although living with a non-parent smoker was marginally related to risk (OR, 1.4; 95% CI, 1.0-2.1), there was no relationship with number of smokers, amount smoked, or duration of smoking. Responses from both case-control participants and mothers also revealed no relationship between either maternal smoking while pregnant or while breast-feeding. Results did not differ by TGCT histology (seminoma, non-seminoma). These results do not support the hypothesis that passive smoking, either in utero or in childhood, is related to risk of TGCT. Other early life exposures, however, may explain the familial clustering of lung cancer in mothers and TGCT in sons. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - McGlynn, Katherine A AU - Zhang, Yawei AU - Sakoda, Lori C AU - Rubertone, Mark V AU - Erickson, Ralph L AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA. mcglynnk@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1820 EP - 1824 VL - 15 IS - 10 SN - 1055-9965, 1055-9965 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Maternal Behavior KW - Seminoma -- etiology KW - Humans KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Middle Aged KW - Adolescent KW - Environmental Exposure -- adverse effects KW - Seminoma -- epidemiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Neoplasms, Germ Cell and Embryonal -- etiology KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Mothers -- statistics & numerical data KW - Testicular Neoplasms -- etiology KW - Tobacco Smoke Pollution -- adverse effects KW - Smoking -- adverse effects KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68952953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Maternal+smoking+and+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BZhang%2C+Yawei%3BSakoda%2C+Lori+C%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BGraubard%2C+Barry+I&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2006-10-01&rft.volume=15&rft.issue=10&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic basis of murine responses to hyperoxia-induced lung injury. AN - 68950967; 17001473 AB - To evaluate the effect of genetic background on oxygen (O2) toxicity, nine genetically diverse mouse strains (129/SvIm, A/J, BALB/cJ, BTBR+(T)/tf/tf, CAST/Ei, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ) were exposed to more than 99% O2 for 72 h. Immediately following the hyperoxic challenge, the mouse strains demonstrated distinct pathophysiologic responses. The BALB/cJ and CAST/Ei strains, which were the only strains to demonstrate mortality from the hyperoxic challenges, were also the only strains to display significant neutrophil infiltration into their lower respiratory tract. In addition, the O2-challenged BALB/cJ and CAST/Ei mice were among six strains (A/J, BALB/cJ, CAST/Ei, BTBR+(T)/tf/tf, DBA/2J, and C3H/HeJ) that had significantly increased interleukin 6 concentrations in the whole lung lavage fluid and were among all but one strain that had large increases in lung permeability compared with air-exposed controls. In contrast, the DBA/2J strain was the only strain not to have any significant alterations in lung permeability following hyperoxic challenge. The expression of the extracellular matrix proteins, including collagens I, III, and IV, fibronectin I, and tenascin C, also varied markedly among the mouse strains, as did the activities of total superoxide dismutase (SOD) and manganese-SOD (Mn-SOD or SOD2). These data suggest that the response to O2 depends, in part, on the genetic background and that some of the strains analyzed can be used to identify specific loci and genes underlying the response to O2. JF - Immunogenetics AU - Whitehead, Gregory S AU - Burch, Lauranell H AU - Berman, Katherine G AU - Piantadosi, Claude A AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 793 EP - 804 VL - 58 IS - 10 SN - 0093-7711, 0093-7711 KW - Cytokines KW - 0 KW - Extracellular Matrix Proteins KW - Lymphokines KW - neutrophil migration inhibitory factor KW - RNA KW - 63231-63-0 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - superoxide dismutase 2 KW - Index Medicus KW - Extracellular Matrix Proteins -- analysis KW - Cytokines -- analysis KW - Mice, Inbred Strains KW - Animals KW - Disease Susceptibility KW - Bronchoalveolar Lavage Fluid -- chemistry KW - RNA -- isolation & purification KW - Superoxide Dismutase -- metabolism KW - Mice KW - Species Specificity KW - Male KW - Lung -- immunology KW - Lung Diseases -- genetics KW - Hyperoxia -- pathology KW - Hyperoxia -- genetics KW - Lung Diseases -- pathology KW - Lung -- chemistry KW - Hyperoxia -- metabolism KW - Lung Diseases -- metabolism KW - Lung -- pathology KW - Lung -- metabolism KW - Lung Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68950967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunogenetics&rft.atitle=Genetic+basis+of+murine+responses+to+hyperoxia-induced+lung+injury.&rft.au=Whitehead%2C+Gregory+S%3BBurch%2C+Lauranell+H%3BBerman%2C+Katherine+G%3BPiantadosi%2C+Claude+A%3BSchwartz%2C+David+A&rft.aulast=Whitehead&rft.aufirst=Gregory&rft.date=2006-10-01&rft.volume=58&rft.issue=10&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Immunogenetics&rft.issn=00937711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-28 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Mol Med. 2001 Jan;7(1):13-9 [11115602] Semin Fetal Neonatal Med. 2005 Jun;10(3):271-82 [15927881] Am J Respir Cell Mol Biol. 2002 Jan;26(1):42-51 [11751202] J Histochem Cytochem. 2002 Mar;50(3):423-31 [11850444] Chest. 2002 Mar;121(3 Suppl):31S-32S [11893671] Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L246-55 [12114185] J Biol Chem. 2002 Aug 16;277(33):29626-33 [12050154] Semin Neonatol. 2003 Feb;8(1):19-27 [12667827] Free Radic Biol Med. 2004 Mar 15;36(6):782-801 [14990357] Lab Invest. 1969 Jan;20(1):101-18 [4988417] Arch Pathol. 1970 Nov;90(5):463-72 [5476243] Lab Invest. 1978 Dec;39(6):640-53 [739764] Pediatrics. 1980 Jun;65(6):1140-4 [7375238] N Engl J Med. 1980 Jul 10;303(2):76-86 [6247652] Am Rev Respir Dis. 1980 Jul;122(1):123-43 [7406333] J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1237-44 [7096148] Lab Invest. 1983 Apr;48(4):448-57 [6339811] N Engl J Med. 1983 Oct 13;309(15):878-83 [6888481] Lab Invest. 1985 Apr;52(4):399-408 [2580120] Bull Eur Physiopathol Respir. 1985 Jul-Aug;21(4):325-9 [3899221] Annu Rev Physiol. 1986;48:721-31 [3518622] Annu Rev Cell Biol. 1985;1:67-90 [3916323] Exp Mol Pathol. 1987 Oct;47(2):219-40 [3653349] J Cell Sci Suppl. 1987;8:199-209 [2460476] Am J Pathol. 1990 Aug;137(2):385-92 [1696785] Am J Physiol. 1990 Dec;259(6 Pt 1):L451-8 [2260676] J Appl Physiol (1985). 1991 Dec;71(6):2352-62 [1778933] Am J Respir Cell Mol Biol. 1992 Nov;7(5):548-55 [1419030] J Biol Chem. 1992 Nov 25;267(33):23937-41 [1385428] Pharmacogenetics. 1993 Jun;3(3):135-43 [8334438] Free Radic Biol Med. 1993 May;14(5):531-9 [8349142] Am J Respir Cell Mol Biol. 1995 Oct;13(4):377-86 [7546767] Pediatr Res. 1995 Dec;38(6):857-63 [8618785] Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):511-8 [8756830] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11853-8 [8876227] Exp Lung Res. 1997 Nov-Dec;23(6):537-52 [9358235] Exp Lung Res. 1998 Mar-Apr;24(2):189-202 [9555576] Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102 [9688940] J Clin Invest. 1999 Apr;103(7):1055-66 [10194479] Minerva Anestesiol. 1999 Jun;65(6):388-92 [10394807] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L394-402 [11435214] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study. AN - 68948349; 17035136 AB - Dicamba is an herbicide commonly applied to crops in the United States and abroad. We evaluated cancer incidence among pesticide applicators exposed to dicamba in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in North Carolina and Iowa. Detailed pesticide exposure information was obtained through a self-administered questionnaire completed from 1993 to 1997. Cancer incidence was followed through 31 December 2002 by linkage to state cancer registries. We used Poisson regression to estimate rate ratios and 95% confidence intervals for cancer subtypes by tertiles of dicamba exposure. Two dicamba exposure metrics were used: lifetime exposure days and intensity-weighted lifetime exposure days (lifetime days x intensity score). A total of 41,969 applicators were included in the analysis, and 22,036 (52.5%) reported ever using dicamba. Exposure was not associated with overall cancer incidence nor were there strong associations with any specific type of cancer. When the reference group comprised low-exposed applicators, we observed a positive trend in risk between lifetime exposure days and lung cancer (p = 0.02), but none of the individual point estimates was significantly elevated. We also observed significant trends of increasing risk for colon cancer for both lifetime exposure days and intensity-weighted lifetime days, although these results are largely due to elevated risk at the highest exposure level. There was no apparent risk for non-Hodgkin lymphoma. Although associations between exposure and lung and colon cancer were observed, we did not find clear evidence for an association between dicamba exposure and cancer risk. JF - Environmental health perspectives AU - Samanic, Claudine AU - Rusiecki, Jennifer AU - Dosemeci, Mustafa AU - Hou, Lifang AU - Hoppin, Jane A AU - Sandler, Dale P AU - Lubin, Jay AU - Blair, Aaron AU - Alavanja, Michael C R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1521 EP - 1526 VL - 114 IS - 10 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Dicamba KW - SJG3M6RY6H KW - Index Medicus KW - Registries KW - Humans KW - Adult KW - Incidence KW - Middle Aged KW - North Carolina -- epidemiology KW - Neoplasms -- classification KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Dicamba -- toxicity KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68948349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+dicamba+in+the+agricultural+health+study.&rft.au=Samanic%2C+Claudine%3BRusiecki%2C+Jennifer%3BDosemeci%2C+Mustafa%3BHou%2C+Lifang%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BLubin%2C+Jay%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-10-01&rft.volume=114&rft.issue=10&rft.spage=1521&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Natl Cancer Inst. 2004 Sep 15;96(18):1375-82 [15367570] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Food Cosmet Toxicol. 1965 Aug;3(2):299-304 [5861114] Environ Mol Mutagen. 1990;15(3):131-5 [2331981] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Am J Ind Med. 1990;18(3):295-301 [2220834] Toxicol Lett. 1991 Dec;59(1-3):175-85 [1755024] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] J Toxicol Environ Health. 1992 Oct;37(2):277-91 [1404486] Cancer Causes Control. 1993 Mar;4(2):153-6 [8481493] J Biochem Mol Toxicol. 1998;12(6):339-44 [9736482] Int J Oncol. 1999 Jan;14(1):79-84 [9863012] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2004 May;22(1):37-55 [15845221] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209-18 [10581215] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1155-63 [11700263] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Nagoya J Med Sci. 2002 Nov;65(3-4):85-94 [12580534] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to Alternaria alternata in US homes is associated with asthma symptoms. AN - 68940896; 17030243 AB - Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments. We examined whether exposure to A alternata in US homes was associated with asthma-related outcomes. The data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed a nationally representative sample of 831 housing units inhabited by 2456 individuals in 75 different locations throughout the United States. An interviewer-administered questionnaire obtained information on demographics, household characteristics, and occupants' health status. Exposure to A alternata was assessed by measuring concentrations of A alternata antigens in vacuumed dust samples using a polyclonal anti-A alternata antibody assay. Dust samples were collected from a bed, a sofa, or a chair, and from bedroom, living room, and kitchen floors. Lifetime prevalence of doctor-diagnosed asthma was 11.2%, and 6.9% of the study subjects reported active asthma symptoms in the past 12 months. The prevalence of current symptomatic asthma increased with increasing Alternaria concentrations in US homes; higher levels of A alternata antigens increased the odds of having asthma symptoms in the past year (relative to the lowest tertile, adjusted odds ratio was 1.52, 95% CI, 0.90-2.55 for the 2nd tertile; and 1.84, 95% CI, 1.18-2.85 for the 3rd tertile). Exposure to A alternata in US homes is associated with active asthma symptoms. Measures that reduce indoor exposure to A alternata may help control asthma exacerbations. JF - The Journal of allergy and clinical immunology AU - Salo, Päivi M AU - Arbes, Samuel J AU - Sever, Michelle AU - Jaramillo, Renee AU - Cohn, Richard D AU - London, Stephanie J AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 892 EP - 898 VL - 118 IS - 4 SN - 0091-6749, 0091-6749 KW - Antigens, Fungal KW - 0 KW - Dust KW - Abridged Index Medicus KW - Index Medicus KW - Cross-Sectional Studies KW - Housing KW - Dust -- analysis KW - Antigens, Fungal -- immunology KW - Humans KW - Dust -- immunology KW - Antigens, Fungal -- analysis KW - Adult KW - Adolescent KW - Male KW - Female KW - Prevalence KW - Asthma -- epidemiology KW - Air Pollution, Indoor -- adverse effects KW - Environmental Exposure KW - Asthma -- microbiology KW - Alternaria -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68940896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Exposure+to+Alternaria+alternata+in+US+homes+is+associated+with+asthma+symptoms.&rft.au=Salo%2C+P%C3%A4ivi+M%3BArbes%2C+Samuel+J%3BSever%2C+Michelle%3BJaramillo%2C+Renee%3BCohn%2C+Richard+D%3BLondon%2C+Stephanie+J%3BZeldin%2C+Darryl+C&rft.aulast=Salo&rft.aufirst=P%C3%A4ivi&rft.date=2006-10-01&rft.volume=118&rft.issue=4&rft.spage=892&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Allergy Clin Immunol. 1992 Oct;90(4 Pt 1):579-88 [1401641] J Allergy Clin Immunol. 1993 Mar;91(3):773-82 [8454800] N Engl J Med. 1991 Feb 7;324(6):359-63 [1987459] J Allergy Clin Immunol. 1985 Dec;76(6):819-25 [4067131] Clin Exp Allergy. 2004 Oct;34(10):1634-41 [15479281] Clin Microbiol Rev. 1995 Apr;8(2):161-79 [7621398] Am J Respir Crit Care Med. 1997 Apr;155(4):1356-61 [9105079] Environ Health Perspect. 1997 Jun;105(6):622-35 [9288497] Ann Allergy Asthma Immunol. 1998 Mar;80(3):279-85 [9532979] J Allergy Clin Immunol. 1998 May;101(5):626-32 [9600499] Clin Exp Allergy. 1998 Apr;28(4):459-67 [9641573] Clin Exp Allergy. 1998 Apr;28 Suppl 1:2-7; discussion 32-6 [9641582] J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563-70 [9802363] Allergy Asthma Proc. 1998 Sep-Oct;19(5):271-5 [9801740] J Allergy Clin Immunol. 1999 Apr;103(4):709-11 [10200024] Clin Exp Allergy. 1999 Nov;29(11):1481-9 [10520075] Ann Allergy Asthma Immunol. 2005 Mar;94(3):313-9; quiz 319-22, 390 [15801241] J Allergy Clin Immunol. 2005 May;115(5):1043-8 [15867864] Indoor Air. 2005;15 Suppl 9:11-9 [15910525] J Allergy Clin Immunol. 2005 Jul;116(1):133-9 [15990786] J Allergy Clin Immunol. 2005 Aug;116(2):377-83 [16083793] J Allergy Clin Immunol. 2005 Sep;116(3):623-9 [16159634] Environ Health Perspect. 2005 Oct;113(10):1405-9 [16203255] J Expo Anal Environ Epidemiol. 1999 Nov-Dec;9(6):560-8 [10638841] Ann Allergy Asthma Immunol. 2000 Jan;84(1):47-54 [10674565] Allergy. 2000 May;55(5):501-4 [10843433] J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1185-93 [10856154] Environ Health Perspect. 2000 Aug;108 Suppl 4:653-9 [10931783] Clin Rev Allergy Immunol. 2000 Jun;18(3):285-300 [10981261] Clin Exp Allergy. 2000 Dec;30(12):1733-9 [11122211] J Allergy Clin Immunol. 2001 Mar;107(3 Suppl):S430-40 [11242604] J Allergy Clin Immunol. 2001 Apr;107(4):641-6 [11295652] Ann Allergy Asthma Immunol. 2001 May;86(5):517-23 [11379802] Am J Respir Crit Care Med. 2001 Aug 1;164(3):455-9 [11500349] Appl Environ Microbiol. 2002 Apr;68(4):1743-53 [11916692] Environ Health Perspect. 2002 May;110(5):527-32 [12003758] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):427-32 [12415491] J Allergy Clin Immunol. 2003 Feb;111(2):285-9 [12589346] Pediatr Allergy Immunol. 2003 Apr;14(2):100-5 [12675755] Ann Allergy Asthma Immunol. 2003 Jun;90(6 Suppl 3):7-12 [12839106] J Allergy Clin Immunol. 2004 Feb;113(2):189-98; quiz 199 [14767427] J Allergy Clin Immunol. 2004 Feb;113(2):227-34 [14767434] J Allergy Clin Immunol. 2004 Mar;113(3):388-91 [15007333] J Allergy Clin Immunol. 2004 Sep;114(3):599-606 [15356564] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of raloxifene on bone mineral density in premenopausal women at increased risk of breast cancer. AN - 68939277; 16868059 AB - Raloxifene is a promising breast cancer prevention agent in postmenopausal women at increased risk for breast cancer. The effects of raloxifene in premenopausal women are unknown. We evaluated the effect of raloxifene in premenopausal women at increased risk for breast cancer on bone mineral density (BMD). This was a phase II clinical trial. This study was conducted at an academic medical center. Thirty-seven premenopausal women at increased risk for breast cancer enrolled in the trial. Thirty subjects began treatment and 27 were evaluable. Raloxifene (60 mg daily) and elemental calcium (500 mg daily) were given for 2 yr. Subjects were followed up off medications for 1 yr. The primary end point was the intrasubject percent change in BMD at 1 yr measured by dual-energy x-ray absorptiometry. The mean baseline lumbar spine density was 1.027 g/cm(2). Lumbar spine density decreased 2.3% at 1 yr (P < 0.00001) and 3.5% at 2 yr (P < .00001). Percent change from yr 2 to 3 was +1.4%. The mean baseline total hip bone density was 0.905 g/cm(2). Total hip density decreased 0.3% at 1 yr and 1.0% at 2 yr (P = 0.033). Percent change from yr 2 to 3 was +1.7%. Raloxifene use is associated with a decrease in BMD in premenopausal women at increased risk for breast cancer. The clinical significance of this decrease is unknown and is attenuated with stopping raloxifene. JF - The Journal of clinical endocrinology and metabolism AU - Eng-Wong, J AU - Reynolds, J C AU - Venzon, D AU - Liewehr, D AU - Gantz, S AU - Danforth, D AU - Liu, E T AU - Chow, C AU - Zujewski, J AD - Medical Oncology Clinical Research Unit, National Cancer Institute, Building 10, Room 12N226, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA. engwongj@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 3941 EP - 3946 VL - 91 IS - 10 SN - 0021-972X, 0021-972X KW - Lipids KW - 0 KW - Selective Estrogen Receptor Modulators KW - Raloxifene Hydrochloride KW - 4F86W47BR6 KW - Fibrinogen KW - 9001-32-5 KW - Abridged Index Medicus KW - Index Medicus KW - Lipids -- blood KW - Fibrinogen -- analysis KW - Premenopause KW - Humans KW - Adult KW - Quality of Life KW - Middle Aged KW - Female KW - Bone Density -- drug effects KW - Raloxifene Hydrochloride -- pharmacology KW - Breast Neoplasms -- prevention & control KW - Selective Estrogen Receptor Modulators -- pharmacology KW - Raloxifene Hydrochloride -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68939277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Effect+of+raloxifene+on+bone+mineral+density+in+premenopausal+women+at+increased+risk+of+breast+cancer.&rft.au=Eng-Wong%2C+J%3BReynolds%2C+J+C%3BVenzon%2C+D%3BLiewehr%2C+D%3BGantz%2C+S%3BDanforth%2C+D%3BLiu%2C+E+T%3BChow%2C+C%3BZujewski%2C+J&rft.aulast=Eng-Wong&rft.aufirst=J&rft.date=2006-10-01&rft.volume=91&rft.issue=10&rft.spage=3941&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Endocrinol Metab. 2006 Oct;91(10):3754-6 [17028288] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes. AN - 68930874; 17020987 AB - The identification of tumor antigens recognized by cytotoxic and T helper lymphocytes has led to the development of specific cancer vaccines. Immunization with tumor antigen-pulsed dendritic cells has proved effective at eliciting elevated levels of tumor antigen-specific T cells in patient blood, but objective clinical responses remain rare, suggesting that vaccine-induced T cells are not trafficking optimally to site(s) of tumor burden. Accumulating evidence from animal models suggests that route of immunization can have a substantial influence on the subsequent migration of primed, activated T cells in vivo. In a clinical trial designed to elicit more effective cytotoxic T-cell mediated antitumor responses, metastatic melanoma patients were immunized directly via a peripheral intralymphatic route with autologous dendritic cells pulsed with HLA-A*0201-restricted melanoma-associated peptide antigens derived from MART-1 and gp100. Within 10 days of intralymphatic dendritic cell vaccination, four of six patients developed dramatic and diffuse erythematous rashes in sun-exposed areas of skin that showed extensive T-cell infiltration. CTLs grown from rash biopsies were strongly enriched for tumor antigen-specific T cells that had elevated expression of cutaneous lymphocyte antigen and chemokine receptor-6, consistent with a skin-homing phenotype. Of note, the only patient in the study with cutaneously localized disease showed a significant regression of metastatic lesions following the development of a surrounding rash. The evidence presented here is consistent with immunization studies in animal models and supports the concept that T cells are "imprinted" in peripheral lymph node sites to express specific ligands and chemokine receptors that allow them to migrate to skin. Furthermore, the preferential migration of the T cells to sun-exposed cutaneous sites suggests that inflammation plays a critical role in this migration. These observations suggest that further study of the effects of immunization route and inflammation on T-cell migration in humans is warranted, and could lead to vaccination approaches that would more reliably direct trafficking of activated T cells to diverse sites of metastatic disease. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Grover, Amelia AU - Kim, Grace J AU - Lizée, Gregory AU - Tschoi, Mary AU - Wang, Gang AU - Wunderlich, John R AU - Rosenberg, Steven A AU - Hwang, Sam T AU - Hwu, Patrick AD - Surgery Branch and Dermatology Branch, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 5801 EP - 5808 VL - 12 IS - 19 SN - 1078-0432, 1078-0432 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - HLA-A2 Antigen KW - MART-1 Antigen KW - MLANA protein, human KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - PMEL protein, human KW - gp100 Melanoma Antigen KW - Index Medicus KW - Humans KW - Neoplasm Proteins -- immunology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Vaccination KW - HLA-A2 Antigen -- immunology KW - Cells, Cultured KW - Adult KW - Cytotoxicity Tests, Immunologic KW - Middle Aged KW - Antigens, Neoplasm -- immunology KW - Membrane Glycoproteins -- immunology KW - Female KW - Male KW - Dendritic Cells -- immunology KW - Dendritic Cells -- metabolism KW - Skin Neoplasms -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Melanoma -- secondary KW - Immunotherapy KW - Cancer Vaccines -- therapeutic use KW - Skin Neoplasms -- therapy KW - CD4-Positive T-Lymphocytes -- immunology KW - Melanoma -- therapy KW - Melanoma -- immunology KW - Skin Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68930874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Intralymphatic+dendritic+cell+vaccination+induces+tumor+antigen-specific%2C+skin-homing+T+lymphocytes.&rft.au=Grover%2C+Amelia%3BKim%2C+Grace+J%3BLiz%C3%A9e%2C+Gregory%3BTschoi%2C+Mary%3BWang%2C+Gang%3BWunderlich%2C+John+R%3BRosenberg%2C+Steven+A%3BHwang%2C+Sam+T%3BHwu%2C+Patrick&rft.aulast=Grover&rft.aufirst=Amelia&rft.date=2006-10-01&rft.volume=12&rft.issue=19&rft.spage=5801&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Jan 1;162(1):186-94 [9886385] J Exp Med. 1999 May 17;189(10):1631-8 [10330442] Adv Immunol. 1999;72:209-53 [10361577] Cancer Immunol Immunother. 1999 May-Jun;48(2-3):118-22 [10414465] Nature. 1999 Aug 19;400(6746):776-80 [10466728] Science. 1999 Oct 15;286(5439):525-8 [10521347] Eur J Immunol. 2005 Feb;35(2):568-74 [15682446] J Exp Med. 1999 Nov 1;190(9):1241-56 [10544196] Curr Opin Immunol. 2000 Jun;12(3):336-41 [10781407] J Exp Med. 2000 Sep 4;192(5):761-8 [10974041] J Immunol. 2000 Dec 15;165(12):6677-81 [11120783] J Immunol. 2001 Mar 15;166(6):4254-9 [11238679] Cancer Immunol Immunother. 2001 Mar;50(1):3-15 [11315507] Nature. 2001 May 17;411(6835):380-4 [11357146] Cancer Res. 2001 Sep 1;61(17):6451-8 [11522640] J Exp Med. 2001 Nov 19;194(10):1541-7 [11714760] Nat Med. 2002 Feb;8(2):157-65 [11821900] Immunity. 2002 Jan;16(1):1-4 [11825560] Curr Opin Allergy Clin Immunol. 2001 Oct;1(5):461-7 [11964728] Blood. 2002 Dec 1;100(12):3853-60 [12433694] Blood. 2003 Mar 1;101(5):1677-82 [12406880] Blood. 2003 Jul 1;102(1):36-42 [12560234] Nat Immunol. 2004 Jan;5(1):7-10 [14699398] J Immunol. 2004 Jan 15;172(2):857-63 [14707056] Cancer Invest. 2003;21(6):873-86 [14735692] Nat Rev Immunol. 2004 Mar;4(3):211-22 [15039758] Nat Med. 2004 Sep;10(9):909-15 [15340416] Am J Pathol. 1990 May;136(5):1053-68 [1693467] J Invest Dermatol. 1993 Jan;100(1):35S-41S [8423392] J Biol Chem. 1997 Jun 6;272(23):14893-8 [9169459] J Exp Med. 1997 Sep 15;186(6):837-44 [9294138] Nat Med. 1998 Mar;4(3):328-32 [9500607] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. AN - 68930597; 17020984 AB - The DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer therapy. A phase I trial was done to examine pharmacokinetics, toxicities, and gene expression mediated by 5-aza-2'-deoxycytidine (DAC) in patients with thoracic malignancies. Thirty-five patients with cancers refractory to standard therapy received continuous 72-hour DAC infusions using a phase I dose-escalation schema. Each full course of therapy consisted of two identical 35-day cycles. Plasma DAC levels were evaluated by liquid chromatography-mass spectrometry techniques. Quantitative reverse transcription-PCR, methylation-specific PCR, and immunohistochemical techniques were used to evaluate NY-ESO-1, MAGE-3, and p16 expression in tumor biopsies. Long oligonucleotide arrays were used to evaluate gene expression profiles in laser-captured tumor cells before and after DAC exposure. Thirty-five patients were evaluable for toxicities; 25 were evaluable for treatment response. Myelosuppression constituted dose-limiting toxicity. The maximum tolerated dose of DAC was 60 to 75 mg/m(2) depending on the number of prior cytotoxic chemotherapy regimens. No objective responses were observed. Plasma DAC concentrations approximated thresholds for gene induction in cultured cancer cells. Target gene induction was observed in 36% of patients. Posttreatment antibodies to NY-ESO-1 were detected in three patients exhibiting NY-ESO-1 induction in their tumor tissues. Complex, heterogeneous gene expression profiles were observed in pretreatment and posttreatment tissues. Prolonged DAC infusions can modulate gene expression in primary thoracic malignancies. These findings support further evaluation of DNA-demethylating agents alone or in combination with other regimens targeting induced gene products for the treatment of these neoplasms. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Schrump, David S AU - Fischette, Maria R AU - Nguyen, Dao M AU - Zhao, Ming AU - Li, Xinmin AU - Kunst, Tricia F AU - Hancox, Ana AU - Hong, Julie A AU - Chen, G Aaron AU - Pishchik, Vitaliy AU - Figg, William D AU - Murgo, Anthony J AU - Steinberg, Seth M AD - Thoracic Oncology Section Surgery Branch, Cancer Therapy Evaluation Program, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. davidschrump@nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 5777 EP - 5785 VL - 12 IS - 19 SN - 1078-0432, 1078-0432 KW - Antigens, Neoplasm KW - 0 KW - Antimetabolites, Antineoplastic KW - CTAG1B protein, human KW - MAGEA3 protein, human KW - Membrane Proteins KW - Neoplasm Proteins KW - decitabine KW - 776B62CQ27 KW - DNA Modification Methylases KW - EC 2.1.1.- KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Membrane Proteins -- metabolism KW - Humans KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - DNA Modification Methylases -- antagonists & inhibitors KW - Mesothelioma -- genetics KW - Aged KW - Carcinoma, Squamous Cell -- metabolism KW - Membrane Proteins -- genetics KW - Transcriptional Activation KW - Mesothelioma -- drug therapy KW - Genes, p16 -- physiology KW - Mesothelioma -- metabolism KW - Neoplasm Proteins -- genetics KW - Adult KW - Carcinoma, Squamous Cell -- genetics KW - Antigens, Neoplasm -- metabolism KW - Middle Aged KW - Maximum Tolerated Dose KW - Antigens, Neoplasm -- genetics KW - Neoplasm Proteins -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Male KW - Female KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Lung Neoplasms -- drug therapy KW - Pleural Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Antimetabolites, Antineoplastic -- pharmacology KW - Esophageal Neoplasms -- metabolism KW - Esophageal Neoplasms -- genetics KW - Lung Neoplasms -- genetics KW - Pleural Neoplasms -- drug therapy KW - Pleural Neoplasms -- metabolism KW - Esophageal Neoplasms -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68930597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+study+of+decitabine-mediated+gene+expression+in+patients+with+cancers+involving+the+lungs%2C+esophagus%2C+or+pleura.&rft.au=Schrump%2C+David+S%3BFischette%2C+Maria+R%3BNguyen%2C+Dao+M%3BZhao%2C+Ming%3BLi%2C+Xinmin%3BKunst%2C+Tricia+F%3BHancox%2C+Ana%3BHong%2C+Julie+A%3BChen%2C+G+Aaron%3BPishchik%2C+Vitaliy%3BFigg%2C+William+D%3BMurgo%2C+Anthony+J%3BSteinberg%2C+Seth+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2006-10-01&rft.volume=12&rft.issue=19&rft.spage=5777&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats. AN - 68929765; 16977594 AB - The cancer bioassay for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) conducted by the Dow Chemical company in the mid 70s has been used extensively for conducting quantitative cancer risk assessments for human exposure to TCDD. More recently the National Toxicology Program (NTP) conducted a cancer bioassay of similar design as part of its evaluation of the dioxin toxic equivalency factor methodology. This report compares the design and the results of these two cancer bioassays. This comparison confirms, in most cases, previously published and widely used carcinogenic response characteristics with respect to dose, time course, organ selectivity, tumor type and maximum intensity of TCDD-induced carcinogenicity and toxicity in the Sprague-Dawley rat. Specifically, increases in the incidences of neoplasms were seen in both studies in the liver, lung and oral mucosa. The most notable difference was the significant increase in the incidence of cholangiocarcinoma of the liver seen in the NTP study but not in the Dow study. The experimental designs for the two studies are similar but some protocol parameters differed, such as vehicle, dosing schedule, diet and rat sub-strain utilized. Differences in the shapes of the dose response curves for several neoplasms were noted between the studies, with the NTP study showing non-linearity for all neoplasms. This may result from differences in the experimental protocols as well as divergence in the biological behavior of the different stocks of Sprague-Dawley rat strains used. JF - Molecular nutrition & food research AU - Walker, Nigel J AU - Wyde, Michael E AU - Fischer, Lawrence J AU - Nyska, Abraham AU - Bucher, John R AD - Environmental Toxicology Program, National Institute of Environmental Health Sciences, Natinal Institutes of Health, Research Triangle Park, NC 27709, USA. walker3@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 934 EP - 944 VL - 50 IS - 10 SN - 1613-4125, 1613-4125 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Index Medicus KW - Rats KW - Mouth Neoplasms -- chemically induced KW - Animals KW - Rats, Sprague-Dawley KW - Hyperplasia KW - Dose-Response Relationship, Drug KW - Kinetics KW - Bile Ducts -- pathology KW - Liver Neoplasms -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Cholangiocarcinoma -- chemically induced KW - Female KW - Polychlorinated Dibenzodioxins -- administration & dosage KW - Neoplasms -- chemically induced KW - Toxicity Tests KW - Polychlorinated Dibenzodioxins -- toxicity KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68929765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=Comparison+of+chronic+toxicity+and+carcinogenicity+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+%28TCDD%29+in+2-year+bioassays+in+female+Sprague-Dawley+rats.&rft.au=Walker%2C+Nigel+J%3BWyde%2C+Michael+E%3BFischer%2C+Lawrence+J%3BNyska%2C+Abraham%3BBucher%2C+John+R&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=16134125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Apr 14;145(2-3):103-13 [10771135] J Endocrinol. 1987 Apr;113(1):71-80 [3585227] J Appl Toxicol. 2001 May-Jun;21(3):211-9 [11404832] Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):219-26 [11701191] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] J Toxicol Environ Health A. 2002 Jun 28;65(12):825-42 [12079609] Toxicol Pathol. 2004 Jan-Feb;32(1):41-9 [14713547] Cardiovasc Toxicol. 2003;3(4):299-310 [14734827] Toxicol Appl Pharmacol. 2004 Jan 15;194(2):156-68 [14736496] Environ Health Perspect. 2004 Jun;112(8):903-9 [15175180] Toxicol Pathol. 2004 May-Jun;32(3):333-7 [15204975] Toxicol Appl Pharmacol. 1976 Mar;35(3):553-74 [1265768] Toxicol Appl Pharmacol. 1978 Nov;46(2):279-303 [734660] Toxicol Sci. 2005 May;85(1):594-606 [15716480] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Regul Toxicol Pharmacol. 1992 Jun;15(3):245-52 [1509118] Prog Clin Biol Res. 1994;387:139-54 [7972244] Toxicol Pathol. 1996 Sep-Oct;24(5):564-72 [8923677] Annu Rev Cell Dev Biol. 1996;12:55-89 [8970722] Toxicol Sci. 2005 Jan;83(1):64-77 [15509667] Environ Health Perspect. 2005 Jan;113(1):43-8 [15626646] Toxicol Pathol. 2005;33(1):165-74 [15805068] Pathology. 2001 May;33(2):130-41 [11358043] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update on the treatment of lupus nephritis. AN - 68929228; 16929249 AB - Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. Although the use of aggressive immunosuppression has improved both patient and renal survival over the past several decades, the optimal treatment of LN remains challenging. Improved outcomes have come at the expense of significant adverse effects owing to therapy. Moreover with long-term survival, the chronic adverse effects of effective therapies including risk of malignancy, atherosclerosis, infertility, and bone disease all become more important. Finally, some patients fail to achieve remission with standard cytotoxic therapy and others relapse when therapy is reduced. For these reasons, recent clinical trials have attempted to define alternate treatment protocols that appear to be efficacious in achieving and maintaining remission, but with less toxicity than standard regimens. This paper discusses established and newer treatment options for patients with proliferative and membranous LN, with an emphasis on the results of these recent clinical trials. We also review the experimental and human data regarding some of the novel targeted forms of therapy that are under investigation and in different phases of clinical trials. JF - Kidney international AU - Waldman, M AU - Appel, G B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland 20892, USA. waldmanm@niddk.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1403 EP - 1412 VL - 70 IS - 8 SN - 0085-2538, 0085-2538 KW - Immunologic Factors KW - 0 KW - Immunosuppressive Agents KW - Index Medicus KW - Lupus Erythematosus, Systemic -- immunology KW - Lupus Erythematosus, Systemic -- complications KW - Randomized Controlled Trials as Topic KW - Humans KW - Chemotherapy, Adjuvant KW - Lupus Nephritis -- drug therapy KW - Immunologic Factors -- physiology KW - Lupus Nephritis -- etiology KW - Immunologic Factors -- therapeutic use KW - Lupus Nephritis -- immunology KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68929228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Update+on+the+treatment+of+lupus+nephritis.&rft.au=Waldman%2C+M%3BAppel%2C+G+B&rft.aulast=Waldman&rft.aufirst=M&rft.date=2006-10-01&rft.volume=70&rft.issue=8&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dietary factors of one-carbon metabolism and prostate cancer risk. AN - 68928900; 17023722 AB - Folate is hypothesized to be inversely associated with the risk of several cancers, but such a potential association has not been well studied for prostate cancer. Vitamin B-6, vitamin B-12, methionine, and alcohol can influence folate-related metabolism. The objective was to investigate the associations between dietary factors of one-carbon metabolism and prostate cancer risk within the alpha-Tocopherol, beta-Carotene Cancer Prevention Study. Of the cohort's 27 111 Finnish male smokers aged 50-69 y who had complete dietary data, 1270 had a diagnosis of incident prostate cancer between 1985 and 2002. Folate, vitamin B-6, vitamin B-12, methionine, and alcohol intakes were estimated from a 276-item modified dietary history questionnaire. Cox proportional hazard models, adjusted for age and vitamin supplement use, estimated relative risks (RR) and 95% CIs. Vitamin B-6 intake was inversely associated with prostate cancer risk (RR for highest versus lowest quintile: 0.88; 95% CI: 0.72, 1.07; P for trend = 0.045), whereas vitamin B-12 intake was associated with significantly increased risk (RR = 1.36; 95% CI: 1.14, 1.96; P for trend = 0.01). No association between folate or alcohol intake and prostate cancer risk was observed. No differences were found in the above associations according to stage of disease or subgroups of several potential effect modifiers. We found no convincing evidence for a protective role of one-carbon metabolism against prostate cancer, although these observations can be generalized only to smokers. The possible modest protective association with vitamin B-6 and the significantly elevated risk with vitamin B-12 intake warrant further investigation. JF - The American journal of clinical nutrition AU - Weinstein, Stephanie J AU - Stolzenberg-Solomon, Rachael AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. weinstes@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 929 EP - 935 VL - 84 IS - 4 SN - 0002-9165, 0002-9165 KW - beta Carotene KW - 01YAE03M7J KW - Ethanol KW - 3K9958V90M KW - Carbon KW - 7440-44-0 KW - Vitamin B 6 KW - 8059-24-3 KW - Folic Acid KW - 935E97BOY8 KW - Methionine KW - AE28F7PNPL KW - One-Carbon Group Transferases KW - EC 2.1.- KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Vitamin B 12 KW - P6YC3EG204 KW - Abridged Index Medicus KW - Index Medicus KW - beta Carotene -- administration & dosage KW - Randomized Controlled Trials as Topic KW - Double-Blind Method KW - Vitamin B 6 -- administration & dosage KW - Humans KW - Ethanol -- administration & dosage KW - Aged KW - Alcohol Drinking KW - One-Carbon Group Transferases -- metabolism KW - Risk Assessment KW - Folic Acid -- administration & dosage KW - Prospective Studies KW - alpha-Tocopherol -- administration & dosage KW - Vitamin B 12 -- adverse effects KW - Risk Factors KW - Case-Control Studies KW - Methionine -- administration & dosage KW - Middle Aged KW - Vitamin B 12 -- administration & dosage KW - Finland -- epidemiology KW - Male KW - Proportional Hazards Models KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- epidemiology KW - Prostatic Neoplasms -- chemically induced KW - Carbon -- metabolism KW - Smoking -- adverse effects KW - Prostatic Neoplasms -- prevention & control KW - Dietary Supplements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Dietary+factors+of+one-carbon+metabolism+and+prostate+cancer+risk.&rft.au=Weinstein%2C+Stephanie+J%3BStolzenberg-Solomon%2C+Rachael%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Weinstein&rft.aufirst=Stephanie&rft.date=2006-10-01&rft.volume=84&rft.issue=4&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai. AN - 68924744; 17018877 AB - Alcohol is a risk factor for liver fibrosis and hepatocellular carcinoma. On the other hand, light alcoholic beverage consumption is believed to be beneficial because of the effects of both alcohol and nonalcoholic components of the beverage. Maotai is a commonly consumed beverage in China containing 53% alcohol. Epidemiological and experimental studies show that Maotai is less toxic to the liver than ethanol alone. To examine the differential effects of Maotai and ethanol, a low dose of Maotai or an equal amount of ethanol (53%, v/v in water, 5 ml/kg) were given to male mice daily for 1 week, and hepatic RNA was extracted for microarray analysis. Approximately 10% of genes on the liver-selective custom array (588 genes) were altered following Maotai or ethanol administration, but Maotai treated livers had fewer alterations compared with ethanol alone. Real-time reverse transcription-polymerase chain reaction confirmed and extended microarray results on selected genes. An induction of metallothionein and heme oxygenase-1 occurred with Maotai, which could not be explained by alcohol consumption alone, whereas the attenuation of ethanol responsive genes such as quinone dehydrogenase, DNA-ligase 1, IGFBP1, and IL-1beta suggests less liver injury occurred with Maotai. The expression of genes related to liver fibrosis, such as cytokeratin-18, was slightly increased by the high dose of ethanol, but was unchanged in the Maotai group. In summary, gene expression analysis indicates that Maotai induces a different response than ethanol alone. The dramatic induction of metallothionein and heme oxygenase-1 with Maotai could be important adaptive responses to reduce alcoholic liver injury. JF - Experimental biology and medicine (Maywood, N.J.) AU - Liu, Jie AU - Cheng, Min-Liang AU - Shi, Jin-Zheng AU - Yang, Qin AU - Wu, Jun AU - Li, Cheng-Xiu AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1535 EP - 1541 VL - 231 IS - 9 SN - 1535-3702, 1535-3702 KW - DNA Primers KW - 0 KW - Ethanol KW - 3K9958V90M KW - Metallothionein KW - 9038-94-2 KW - Heme Oxygenase (Decyclizing) KW - EC 1.14.14.18 KW - Index Medicus KW - Animals KW - Base Sequence KW - Oligonucleotide Array Sequence Analysis KW - Enzyme Induction KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression -- drug effects KW - Liver -- enzymology KW - Heme Oxygenase (Decyclizing) -- biosynthesis KW - Beverages KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Metallothionein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68924744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.atitle=Differential+effects+between+maotai+and+ethanol+on+hepatic+gene+expression+in+mice%3A+Possible+role+of+metallothionein+and+heme+oxygenase-1+induction+by+maotai.&rft.au=Liu%2C+Jie%3BCheng%2C+Min-Liang%3BShi%2C+Jin-Zheng%3BYang%2C+Qin%3BWu%2C+Jun%3BLi%2C+Cheng-Xiu%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-10-01&rft.volume=231&rft.issue=9&rft.spage=1535&rft.isbn=&rft.btitle=&rft.title=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.issn=15353702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-25 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. AN - 68924004; 17015814 AB - The need for improved therapeutic agents that more quickly and effectively treat depression is critical. In a pilot study we evaluated the role of the cholinergic system in cognitive symptoms of depression and unexpectedly observed rapid reductions in depression severity following the administration of the antimuscarinic drug scopolamine hydrobromide (4 microg/kg intravenously) compared with placebo (P = .002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine. To evaluate scopolamine as a potential antidepressant agent. Two studies were conducted: a double-blind, placebo-controlled, dose-finding study followed by a double-blind, placebo-controlled, crossover clinical trial. The National Institute of Mental Health. Patients Currently depressed outpatients aged 18 to 50 years meeting DSM-IV criteria for recurrent major depressive disorder or bipolar disorder. Of 39 eligible patients, 19 were randomized and 18 completed the trial. Multiple sessions including intravenous infusions of placebo or scopolamine hydrobromide (4 microg/kg). Individuals were randomized to a placebo/scopolamine or scopolamine/placebo sequence (series of 3 placebo sessions and series of 3 scopolamine sessions). Sessions occurred 3 to 5 days apart. Psychiatric evaluations using the Montgomery-Asberg Depression Rating Scale and the Hamilton Anxiety Rating Scale were performed to assess antidepressant and antianxiety responses to scopolamine. The placebo/scopolamine group showed no significant change during placebo infusion vs baseline; reductions in depression and anxiety rating scale scores (P<.001 for both) were observed after the administration of scopolamine compared with placebo. The scopolamine/placebo group also showed reductions in depression and anxiety rating scale scores (P<.001 for both) after the administration of scopolamine, relative to baseline, and these effects persisted as they received placebo. In both groups, improvement was significant at the first evaluation after scopolamine administration (P< or =.002). Rapid, robust antidepressant responses to the antimuscarinic scopolamine occurred in currently depressed patients who predominantly had poor prognoses. JF - Archives of general psychiatry AU - Furey, Maura L AU - Drevets, Wayne C AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. mfurey@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1121 EP - 1129 VL - 63 IS - 10 SN - 0003-990X, 0003-990X KW - Antidepressive Agents KW - 0 KW - Muscarinic Antagonists KW - Placebos KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Depressive Disorder, Major -- drug therapy KW - Psychiatric Status Rating Scales KW - Infusions, Intravenous KW - Double-Blind Method KW - Humans KW - Depressive Disorder, Major -- psychology KW - Bipolar Disorder -- drug therapy KW - Adult KW - Treatment Outcome KW - Bipolar Disorder -- psychology KW - Pilot Projects KW - Research Design KW - Male KW - Female KW - Scopolamine Hydrobromide -- adverse effects KW - Muscarinic Antagonists -- therapeutic use KW - Scopolamine Hydrobromide -- administration & dosage KW - Muscarinic Antagonists -- adverse effects KW - Muscarinic Antagonists -- administration & dosage KW - Antidepressive Agents -- administration & dosage KW - Depressive Disorder -- psychology KW - Depressive Disorder -- drug therapy KW - Antidepressive Agents -- therapeutic use KW - Scopolamine Hydrobromide -- therapeutic use KW - Antidepressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68924004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Antidepressant+efficacy+of+the+antimuscarinic+drug+scopolamine%3A+a+randomized%2C+placebo-controlled+clinical+trial.&rft.au=Furey%2C+Maura+L%3BDrevets%2C+Wayne+C&rft.aulast=Furey&rft.aufirst=Maura&rft.date=2006-10-01&rft.volume=63&rft.issue=10&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacopsychiatry. 1996 Jan;29(1):23-6 [8852530] Psychosom Med. 1974 May-Jun;36(3):248-57 [4829619] Br J Med Psychol. 1959;32(1):50-5 [13638508] J Clin Psychiatry. 2004;65 Suppl 15:15-20 [15554791] J Psychiatr Res. 2005 Mar;39(2):145-50 [15589562] Biochem Biophys Res Commun. 2006 Feb 10;340(2):435-40 [16376302] J Physiol. 2006 Feb 1;570(Pt 3):553-65 [16322058] Nature. 1977 Apr 21;266(5604):730-2 [559941] J Affect Disord. 1999 Oct;55(2-3):149-57 [10628884] Psychiatry Res. 1999 Dec 13;89(1):1-20 [10643873] Biol Psychiatry. 2000 Feb 15;47(4):351-4 [10686270] J Clin Psychopharmacol. 2000 Aug;20(4):417-22 [10917402] J Clin Pharmacol. 2001 Jan;41(1):51-60 [11144994] Br J Psychiatry. 2001 Mar;178:234-41 [11230034] Depress Anxiety. 1998;7 Suppl 1:11-7 [9597346] Arch Gen Psychiatry. 1978 Jan;35(1):119-22 [339869] Br J Psychiatry. 1978 Nov;133:429-35 [728692] J Psychiatr Res. 1979;15(1):21-40 [219193] Nature. 1979 Sep 13;281(5727):148-50 [471061] Eur J Pharmacol. 1979 Oct 1;58(3):331-4 [510364] Psychiatry Res. 1979 Jul;1(1):17-22 [233154] J Clin Psychiatry. 1981 Aug;42(8):307-12 [7251567] J Clin Psychopharmacol. 1981 Jan;1(1):14-20 [6117578] J Clin Psychopharmacol. 1981 Jul;1(4):186-92 [7028800] Physiol Behav. 1982 Feb;28(2):307-11 [7079344] Mayo Clin Proc. 1983 Jan;58(1):40-6 [6130192] Psychiatry Res. 1983 Jul;9(3):191-200 [6312479] J Clin Psychiatry. 1983 Sep;44(9 Pt 2):4-9 [6313632] Psychopharmacology Suppl. 1985;2:9-18 [2860665] Am J Psychiatry. 1985 Jun;142(6):738-40 [4003595] Biol Psychiatry. 1986 Jul;21(8-9):813-29 [3015271] Psychopharmacology (Berl). 1988;94(2):147-60 [3127840] Arch Gen Psychiatry. 1988 Oct;45(10):906-12 [3048225] Arch Gen Psychiatry. 1989 Jan;46(1):29-35 [2642691] Arch Gen Psychiatry. 1989 May;46(5):421-8 [2712660] Neuropsychopharmacology. 1991 Feb;4(2):125-30 [2025378] Biol Psychiatry. 1991 Jul 15;30(2):157-69 [1655072] Neuropsychopharmacology. 1992 Nov;7(3):197-204 [1388644] Life Sci. 1993;52(12):1023-9 [8445992] Neurosci Biobehav Rev. 1993 Spring;17(1):51-68 [8455816] Biochem Pharmacol. 1993 Jun 9;45(11):2352-4 [8100134] J Psychiatr Res. 1994 May-Jun;28(3):195-210 [7932282] Psychopharmacology (Berl). 1994 May;114(4):559-65 [7855217] Psychopharmacology (Berl). 1995 Jun;119(4):440-8 [7480524] J Clin Psychiatry. 2001;62 Suppl 16:5-9 [11480882] J Clin Psychiatry. 2001;62 Suppl 16:10-7 [11480879] Am J Psychiatry. 2001 Nov;158(11):1843-9 [11691690] Mol Psychiatry. 2002;7 Suppl 1:S71-80 [11986998] Am J Med Genet. 2002 Jul 8;114(5):527-9 [12116189] J Psychiatry Neurosci. 2002 Jul;27(4):250-7 [12174734] Int Clin Psychopharmacol. 2002 Nov;17(6):281-5 [12409681] Ann N Y Acad Sci. 2003 Nov;1003:250-72 [14684451] Sheng Li Xue Bao. 2004 Feb 25;56(1):95-100 [14985837] J Clin Psychiatry. 2004;65 Suppl 4:25-30 [15046538] Curr Med Chem. 2004 Apr;11(7):925-43 [15078174] Hum Mol Genet. 2004 Sep 1;13(17):1903-11 [15229186] Lancet. 1972 Jun 3;1(7762):1236-7 [4113219] Lancet. 1972 Sep 23;2(7778):632-5 [4116781] Comment In: Curr Psychiatry Rep. 2007 Dec;9(6):447-8 [18221623] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. AN - 68919258; 16964312 AB - Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKCalpha is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This inducible model of cutaneous inflammation was used to define mediators of skin inflammation that may have clinical relevance. Activation of cutaneous PKCalpha increased the production of the chemotactic factors cytokine-induced neutrophil chemoattractant (KC) and macrophage inflammatory protein 2 (MIP-2) in murine plasma. TPA treatment of cultured K5-PKCalpha keratinocytes also released KC and MIP-2 into culture supernatants through an NF-kappaB-dependent pathway. MIP-2 and KC mediated the infiltration of neutrophils into the epidermis, since this was prevented by ablating CXCR2 in K5-PKCalpha mice or administering neutralizing antibodies against KC or MIP-2. The neutrophilia resulted from PKCalpha-mediated upregulation of cutaneous G-CSF released into the plasma independent of CXCR2. These responses could be inhibited by topical treatment with a PKCalpha-selective inhibitor. Inhibiting PKCalpha also reduced the basal and TNF-alpha- or TPA-induced expression of CXCL8 in cultured psoriatic keratinocytes, suggesting that PKCalpha activity may contribute to psoriatic inflammation. Thus, skin can be the source of circulating factors that have both local and systemic consequences, and these factors, their receptors, and possibly PKCalpha could be therapeutic targets for inhibition of cutaneous inflammation. JF - The Journal of clinical investigation AU - Cataisson, Christophe AU - Pearson, Andrea J AU - Tsien, Margaret Z AU - Mascia, Francesca AU - Gao, Ji-Liang AU - Pastore, Saveria AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2757 EP - 2766 VL - 116 IS - 10 SN - 0021-9738, 0021-9738 KW - Antibodies KW - 0 KW - Chemokine CXCL1 KW - Chemokine CXCL2 KW - Chemokines KW - Chemokines, CXC KW - Cxcl1 protein, mouse KW - Cxcl2 protein, mouse KW - IL8 protein, human KW - Interleukin-8 KW - Protein Kinase Inhibitors KW - Tumor Necrosis Factor-alpha KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neutrophil Infiltration -- drug effects KW - Humans KW - Keratinocytes -- drug effects KW - Epidermis -- metabolism KW - Aged KW - Mice, Transgenic KW - Mice, Knockout KW - Epidermis -- drug effects KW - Antibodies -- pharmacology KW - Adult KW - Keratinocytes -- metabolism KW - Male KW - Chemokines -- blood KW - Protein Kinase Inhibitors -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Chemokines -- immunology KW - Neutrophil Infiltration -- physiology KW - Mice KW - Gene Expression -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interleukin-8 -- genetics KW - Epidermis -- pathology KW - Middle Aged KW - Female KW - Dermatitis -- pathology KW - Chemokines, CXC -- metabolism KW - Protein Kinase C-alpha -- metabolism KW - Protein Kinase C-alpha -- antagonists & inhibitors KW - Granulocyte Colony-Stimulating Factor -- metabolism KW - Protein Kinase C-alpha -- genetics KW - Granulocyte Colony-Stimulating Factor -- genetics KW - Chemokines, CXC -- immunology KW - Dermatitis -- metabolism KW - Chemokines, CXC -- genetics KW - Granulocyte Colony-Stimulating Factor -- immunology KW - Chemokines, CXC -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68919258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Software+Engineering+and+Applications&rft.atitle=Proposing+a+Systematic+Approach+to+Verify+Software+Requirements&rft.au=Al-Khanjari%2C+Zuhoor+Abdullah+Salim&rft.aulast=Al-Khanjari&rft.aufirst=Zuhoor+Abdullah&rft.date=2014-04-01&rft.volume=7&rft.issue=4&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Journal+of+Software+Engineering+and+Applications&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Feb 1;60(3):595-602 [10676642] J Clin Invest. 2004 Jun;113(12):1664-75 [15199399] Immunity. 2000 Feb;12(2):121-7 [10714678] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] Blood. 2000 May 15;95(10):3032-43 [10807766] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12283-8 [11050248] Shock. 2001 Apr;15(4):278-84 [11303726] J Allergy Clin Immunol. 2001 May;107(5):871-7 [11344355] Int J Cancer. 2001 Sep 1;93(5):635-43 [11477572] Eur J Pharmacol. 2001 Sep 21;427(3):277-83 [11567658] J Immunol. 2001 Dec 15;167(12):7102-10 [11739532] Methods. 2001 Dec;25(4):402-8 [11846609] Pharmacol Rev. 2002 Jun;54(2):227-9 [12037138] Oncogene. 2002 Jul 18;21(31):4728-38 [12101411] Curr Opin Allergy Clin Immunol. 2002 Aug;2(4):325-31 [12130947] Am J Pathol. 2002 Oct;161(4):1409-18 [12368213] Immunity. 2002 Oct;17(4):413-23 [12387736] J Invest Dermatol. 2002 Dec;119(6):1282-9 [12485429] Exp Eye Res. 2003 Feb;76(2):221-31 [12565810] J Biol Chem. 2003 Mar 14;278(11):9944-52 [12645577] Cancer Res. 1999 Nov 15;59(22):5710-8 [10582689] Blood. 2004 Jul 15;104(2):565-71 [15054039] J Invest Dermatol. 1982 Mar;78(3):206-9 [6276474] Am J Pathol. 1986 May;123(2):241-9 [3518475] Acta Derm Venereol. 1990;70(1):57-9 [1967875] J Invest Dermatol. 1990 Oct;95(4):428-35 [2170539] J Invest Dermatol. 1991 Jul;97(1):73-9 [1711550] J Immunol. 1992 Feb 15;148(4):1119-28 [1310708] J Invest Dermatol. 1992 Sep;99(3):294-8 [1512465] Cell Growth Differ. 1992 Apr;3(4):233-9 [1515369] J Immunol. 1993 Oct 15;151(8):4399-406 [7691948] Am J Pathol. 1994 Apr;144(4):820-8 [7512793] Science. 1994 Jul 29;265(5172):682-4 [8036519] Blood. 1994 Sep 15;84(6):1737-46 [7521686] J Biol Chem. 1994 Nov 25;269(47):29355-8 [7961909] J Exp Med. 1994 Dec 1;180(6):2039-48 [7964481] J Immunol. 1995 Jun 1;154(11):6048-57 [7751647] J Immunol. 1995 Aug 15;155(4):2158-64 [7636264] Science. 1995 Sep 15;269(5230):1590-1 [7667641] J Invest Dermatol. 1996 Mar;106(3):526-30 [8648188] J Invest Dermatol. 1996 Nov;107(5):778-82 [8875965] J Exp Med. 1996 Nov 1;184(5):1825-32 [8920870] Immunity. 1996 Nov;5(5):491-501 [8934575] J Clin Invest. 1997 Jun 15;99(12):3009-17 [9185525] J Immunol. 1997 Oct 1;159(7):3595-602 [9317159] J Invest Dermatol. 1998 Jan;110(1):90-4 [9424095] N Engl J Med. 1998 Feb 12;338(7):436-45 [9459648] Blood. 1998 Aug 1;92(3):1062-9 [9680376] J Clin Invest. 1999 Mar;103(6):825-32 [10079103] Mol Cell Biol. 1999 Aug;19(8):5785-99 [10409765] J Cell Sci. 1999 Oct;112 ( Pt 20):3497-506 [10504298] Am J Pathol. 2005 Jan;166(1):117-26 [15632005] J Immunol. 2005 Feb 1;174(3):1686-92 [15661932] J Clin Invest. 2005 May;115(5):1150-62 [15864347] Nat Med. 2005 Jun;11(6):661-5 [15880119] Eur J Immunol. 2005 Sep;35(9):2573-82 [16094689] J Invest Dermatol. 2005 Oct;125(4):615-28 [16185259] J Immunol. 2003 May 1;170(9):4767-75 [12707358] J Immunol. 2003 Sep 1;171(5):2703-13 [12928424] Immunity. 2003 Oct;19(4):583-93 [14563322] Nat Rev Immunol. 2004 Mar;4(3):211-22 [15039758] Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1024-31 [14739142] Pharmacol Rev. 2000 Mar;52(1):145-76 [10699158] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. AN - 68917142; 16959481 AB - Deficiency in the long-chain omega-3 fatty acid, docosahexaenoic acid (DHA) has been associated with increased corticotropin releasing hormone and may contribute to hypothalamic pituitary axis (HPA) hyperactivity. Elevated levels of the neuroactive steroids, allopregnanolone (3alpha,5alpha-THP) and 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) appear to counter-regulate HPA hyperactivity. Plasma essential fatty acids and neurosteroids were assessed among 18 male healthy controls and among 34 male psychiatric patients with DSM-III alcoholism, depression, or both. Among all subjects, lower plasma DHA was correlated with higher plasma THDOC (r = -0.3, P < 0.05) and dihydroprogesterone (DHP) (r = -0.52, P < 0.05). Among psychiatric patients lower DHA was correlated with higher DHP (r = -0.60, P < 0.01), and among healthy controls lower plasma DHA was correlated with higher THDOC (r = -0.83, P < 0.01) and higher isopregnanolone (3beta,5alpha-THP) (r = -0.55, P < 0.05). In this pilot observational study, lower long-chain omega-3 essential fatty acid status was associated with higher neuroactive steroid concentrations, possibly indicating increased feedback inhibition of the HPA axis. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Nieminen, L R G AU - Makino, K K AU - Mehta, N AU - Virkkunen, M AU - Kim, H Y AU - Hibbeln, J R AD - National Institutes of Health, National Institutes on Alcoholism and Alcohol Abuse, Laboratory of Membrane Biophysics and Biochemistry, Bethesda, MD 20814, USA. PY - 2006 SP - 309 EP - 314 VL - 75 IS - 4-5 SN - 0952-3278, 0952-3278 KW - Fatty Acids, Omega-3 KW - 0 KW - Lipids KW - Psychotropic Drugs KW - Steroids KW - Docosahexaenoic Acids KW - 25167-62-8 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - tetrahydrodeoxycorticosterone KW - 4AB717DP4A KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Pregnanolone KW - BXO86P3XXW KW - Index Medicus KW - Lipids -- blood KW - Pregnanolone -- blood KW - Humans KW - Pituitary-Adrenal System -- physiology KW - Desoxycorticosterone -- blood KW - Desoxycorticosterone -- analogs & derivatives KW - Hypothalamo-Hypophyseal System -- physiology KW - Mental Disorders -- blood KW - Pituitary-Adrenal System -- chemistry KW - Docosahexaenoic Acids -- analysis KW - Case-Control Studies KW - Hypothalamo-Hypophyseal System -- chemistry KW - Corticotropin-Releasing Hormone -- analysis KW - Female KW - Male KW - Fatty Acids, Omega-3 -- physiology KW - Steroids -- blood KW - Depression -- blood KW - Psychotropic Drugs -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68917142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Relationship+between+omega-3+fatty+acids+and+plasma+neuroactive+steroids+in+alcoholism%2C+depression+and+controls.&rft.au=Nieminen%2C+L+R+G%3BMakino%2C+K+K%3BMehta%2C+N%3BVirkkunen%2C+M%3BKim%2C+H+Y%3BHibbeln%2C+J+R&rft.aulast=Nieminen&rft.aufirst=L+R&rft.date=2006-10-01&rft.volume=75&rft.issue=4-5&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. AN - 68911293; 17006931 AB - We applied a genome-wide microarray analysis to three transgenic mouse models of liver cancer in which targeted overexpression of c-Myc, E2f1, and a combination of the two was driven by the albumin promoter. Although gene expression profiles in HCC derived in all three transgenic lines were highly similar, oncogene-specific gene expression signatures were identified at an early dysplastic stage of hepatocarcinogenesis. Overexpression of E2f1 was associated with a strong alteration in lipid metabolism, and Srebp1 was identified as a candidate transcription factor responsible for lipogenic enzyme induction. The molecular signature of c-Myc overexpression included the induction of more than 60 genes involved in the translational machinery that correlated with an increase in liver mass. In contrast, the combined activity of c-Myc and E2f1 specifically enhanced the expression of genes involved in mitochondrial metabolism--particularly the components of the respiratory chain--and correlated with an increased ATP synthesis. Thus, the results suggest that E2f1, c-Myc, and their combination may promote liver tumor development by distinct mechanisms. In conclusion, determination of tissue-specific oncogene expression signatures might be useful to identify conserved expression modules in human cancers. JF - Hepatology (Baltimore, Md.) AU - Coulouarn, Cédric AU - Gomez-Quiroz, Luis E AU - Lee, Ju-Seog AU - Kaposi-Novak, Pal AU - Conner, Elizabeth A AU - Goldina, Tatyana A AU - Onishchenko, Galina E AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1003 EP - 1011 VL - 44 IS - 4 SN - 0270-9139, 0270-9139 KW - E2F1 Transcription Factor KW - 0 KW - E2f1 protein, mouse KW - Proto-Oncogene Proteins c-myc KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - DNA Repair KW - Oligonucleotide Array Sequence Analysis KW - Mitochondria, Liver -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Disease Models, Animal KW - Mice KW - Lipid Metabolism -- genetics KW - Up-Regulation KW - Mice, Transgenic KW - Cell Cycle -- genetics KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Gene Expression Regulation, Neoplastic KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - E2F1 Transcription Factor -- genetics KW - E2F1 Transcription Factor -- biosynthesis KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68911293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Oncogene-specific+gene+expression+signatures+at+preneoplastic+stage+in+mice+define+distinct+mechanisms+of+hepatocarcinogenesis.&rft.au=Coulouarn%2C+C%C3%A9dric%3BGomez-Quiroz%2C+Luis+E%3BLee%2C+Ju-Seog%3BKaposi-Novak%2C+Pal%3BConner%2C+Elizabeth+A%3BGoldina%2C+Tatyana+A%3BOnishchenko%2C+Galina+E%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=C%C3%A9dric&rft.date=2006-10-01&rft.volume=44&rft.issue=4&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-03 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medication-induced weight gain and dyslipidemia in patients with schizophrenia. AN - 68909828; 17012676 JF - The American journal of psychiatry AU - Fenton, Wayne S AU - Chavez, Mark R AD - Division of Adult Trasnlation Reserach and Treatment Development, NIMH, Bethesda, MD, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1697 EP - 704; quiz 1858-9 VL - 163 IS - 10 SN - 0002-953X, 0002-953X KW - Antipsychotic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Metabolic Syndrome X -- chemically induced KW - Humans KW - Metabolic Syndrome X -- epidemiology KW - Metabolic Syndrome X -- diagnosis KW - Obesity -- chemically induced KW - Male KW - Comorbidity KW - Obesity -- blood KW - Weight Gain -- drug effects KW - Schizophrenia -- blood KW - Dyslipidemias -- blood KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Schizophrenia -- epidemiology KW - Antipsychotic Agents -- adverse effects KW - Dyslipidemias -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68909828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Medication-induced+weight+gain+and+dyslipidemia+in+patients+with+schizophrenia.&rft.au=Fenton%2C+Wayne+S%3BChavez%2C+Mark+R&rft.aulast=Fenton&rft.aufirst=Wayne&rft.date=2006-10-01&rft.volume=163&rft.issue=10&rft.spage=1697&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiers. AN - 68908608; 17007558 AB - Radiation exposure at a young age is a strong risk factor for thyroid cancer. We conducted a nested case-control study of 69 thyroid cancer cases and 265 controls from a cohort of 14,054 childhood cancer survivors to evaluate the shape of the radiation dose-response relationship, in particular at high doses, and to assess modification of the radiation effects by patient and treatment characteristics. We considered several types of statistical models to estimate the excess relative risk (ERR), mainly guided by radiobiological models. A two-parameter model with a term linear in dose and a negative exponential in dose squared provided the best parsimonious description with an ERR of 1.3 per gray (95% confidence interval 0.4-4.1) at doses below 6 Gy and a relative decrease in ERR of 0.2% per unit dose squared with increasing dose, that is, decreases in the ERR/Gy of 53% at 20 Gy and 95% at 40 Gy. Further analyses using spline models suggested that the significant nonlinearity at high doses was characterized most appropriately as a true downturn rather than a flattening of the dose-response curve. We found no statistically significant modification of the dose-response relationship by patient characteristics; however, the linear parameter (i.e., the ERR/ Gy at doses less than 6 Gy) did decrease consistently and linearly with increasing age at childhood cancer diagnosis, from 4.45 for 0-1-year-olds to 0.48 for 15-20-year-olds. In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses. JF - Radiation research AU - Ronckers, Cécile M AU - Sigurdson, Alice J AU - Stovall, Marilyn AU - Smith, Susan A AU - Mertens, Ann C AU - Liu, Yan AU - Hammond, Sue AU - Land, Charles E AU - Neglia, Joseph P AU - Donaldson, Sarah S AU - Meadows, Anna T AU - Sklar, Charles A AU - Robison, Leslie L AU - Inskip, Peter D AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland. c.m.ronckers@amc.uva.nl Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 618 EP - 628 VL - 166 IS - 4 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Disease-Free Survival KW - Neoplasms -- radiotherapy KW - Risk Factors KW - Radiotherapy Dosage KW - Humans KW - Neoplasms -- epidemiology KW - Incidence KW - Child KW - Dose-Response Relationship, Radiation KW - United States -- epidemiology KW - Male KW - Female KW - Thyroid Neoplasms -- epidemiology KW - Survivors -- statistics & numerical data KW - Risk Assessment -- methods KW - Radiotherapy -- statistics & numerical data KW - Proportional Hazards Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68908608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Thyroid+cancer+in+childhood+cancer+survivors%3A+a+detailed+evaluation+of+radiation+dose+response+and+its+modifiers.&rft.au=Ronckers%2C+C%C3%A9cile+M%3BSigurdson%2C+Alice+J%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BMertens%2C+Ann+C%3BLiu%2C+Yan%3BHammond%2C+Sue%3BLand%2C+Charles+E%3BNeglia%2C+Joseph+P%3BDonaldson%2C+Sarah+S%3BMeadows%2C+Anna+T%3BSklar%2C+Charles+A%3BRobison%2C+Leslie+L%3BInskip%2C+Peter+D&rft.aulast=Ronckers&rft.aufirst=C%C3%A9cile&rft.date=2006-10-01&rft.volume=166&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. AN - 68903018; 16942635 AB - Increasing evidence suggests that enhanced dopamine (DA) neurotransmission in the nucleus accumbens (NAc) may play a role in mediating the reward and reinforcement produced by addictive drugs and in the attentional processing of drug-associated environmental cues. The meso-accumbens DA system is selectively enriched with DA D3 receptors, a DA receptor subtype increasingly implicated in reward-related brain and behavioural processes. From a variety of evidence, it has been suggested that selective DA D3 receptor antagonism may be a useful pharmacotherapeutic approach for treating addiction. The present experiments tested the efficacy of SB-277011A, a selective DA D3 receptor antagonist, in rat models of nicotine-enhanced electrical brain-stimulation reward (BSR), nicotine-induced conditioned locomotor activity (LMA), and nicotine-induced conditioned place preference (CPP). Nicotine was given subcutaneously within the dose range of 0.25-0.6 mg/kg (nicotine-free base). SB-277011A, given intraperitoneally within the dose range of 1-12 mg/kg, dose-dependently reduced nicotine-enhanced BSR, nicotine-induced conditioned LMA, and nicotine-induced CPP. The results suggest that selective D3 receptor antagonism constitutes a new and promising pharmacotherapeutic approach to the treatment of nicotine dependence. JF - The international journal of neuropsychopharmacology AU - Pak, Arlene C AU - Ashby, Charles R AU - Heidbreder, Christian A AU - Pilla, Maria AU - Gilbert, Jeremy AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 585 EP - 602 VL - 9 IS - 5 SN - 1461-1457, 1461-1457 KW - Dopamine Antagonists KW - 0 KW - Nicotinic Agonists KW - Nitriles KW - SB 277011 KW - Tetrahydroisoquinolines KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Drug Interactions KW - Analysis of Variance KW - Rats, Long-Evans KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Association Learning -- drug effects KW - Cues KW - Motor Activity -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Nitriles -- pharmacology KW - Reward KW - Nicotine -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Brain -- drug effects KW - Tetrahydroisoquinolines -- pharmacology KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68903018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+neuropsychopharmacology&rft.atitle=The+selective+dopamine+D3+receptor+antagonist+SB-277011A+reduces+nicotine-enhanced+brain+reward+and+nicotine-paired+environmental+cue+functions.&rft.au=Pak%2C+Arlene+C%3BAshby%2C+Charles+R%3BHeidbreder%2C+Christian+A%3BPilla%2C+Maria%3BGilbert%2C+Jeremy%3BXi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Pak&rft.aufirst=Arlene&rft.date=2006-10-01&rft.volume=9&rft.issue=5&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+neuropsychopharmacology&rft.issn=14611457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drugs Today (Barc). 2004 Apr;40(4):355-65 [15190388] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Science. 1975 Feb 14;187(4176):547-9 [1114313] Psychopharmacology (Berl). 1976 Aug 17;48(3):311-8 [823588] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Psychopharmacology (Berl). 1982;78(3):204-9 [6296898] Physiol Behav. 1985 Sep;35(3):395-403 [3840902] Eur J Pharmacol. 1986 Dec 16;132(2-3):337-8 [3816984] Behav Neurosci. 1987 Apr;101(2):209-14 [3580122] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] Behav Brain Res. 1987 Oct;26(1):57-62 [3675835] Psychiatr Med. 1985;3(4):445-60 [2893431] Eur J Pharmacol. 1988 Jul 7;151(2):233-42 [2844553] Annu Rev Psychol. 1989;40:191-225 [2648975] Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb;339(1-2):208-13 [2725697] Br J Pharmacol. 1989 Sep;98(1):135-40 [2804543] Neurosci Biobehav Rev. 1989 Summer-Fall;13(2-3):123-8 [2530477] Ciba Found Symp. 1990;152:153-62; 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AN - 68898821; 16488893 AB - Studies of latent traits often collect data for multiple items measuring different aspects of the trait. For such data, it is common to consider models in which the different items are manifestations of a normal latent variable, which depends on covariates through a linear regression model. This article proposes a flexible Bayesian alternative in which the unknown latent variable density can change dynamically in location and shape across levels of a predictor. Scale mixtures of underlying normals are used in order to model flexibly the measurement errors and allow mixed categorical and continuous scales. A dynamic mixture of Dirichlet processes is used to characterize the latent response distributions. Posterior computation proceeds via a Markov chain Monte Carlo algorithm, with predictive densities used as a basis for inferences and evaluation of model fit. The methods are illustrated using data from a study of DNA damage in response to oxidative stress. JF - Biostatistics (Oxford, England) AU - Dunson, David B AD - Biostatistics Branch, National Institute of Environmental Health Sciences, MD A3-03, Research Triangle Park, NC 27709, USA. dunson1@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 551 EP - 568 VL - 7 IS - 4 SN - 1465-4644, 1465-4644 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Hydrogen Peroxide -- toxicity KW - Biometry -- methods KW - DNA Damage KW - Humans KW - Oxidative Stress KW - Algorithms KW - Models, Statistical KW - Markov Chains KW - Monte Carlo Method KW - Statistics, Nonparametric KW - Cell Line KW - Bayes Theorem KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68898821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biostatistics+%28Oxford%2C+England%29&rft.atitle=Bayesian+dynamic+modeling+of+latent+trait+distributions.&rft.au=Dunson%2C+David+B&rft.aulast=Dunson&rft.aufirst=David&rft.date=2006-10-01&rft.volume=7&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Biostatistics+%28Oxford%2C+England%29&rft.issn=14654644&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. AN - 68898623; 16728435 AB - Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double-strand breaks (DSB) are one of the most severe DNA lesions caused directly and indirectly by benzene metabolites. DSB may lead to chromosome aberrations, apoptosis and hematopoietic progenitor cell suppression. We hypothesized that genetic polymorphisms in genes involved in DNA DSB repair may modify benzene-induced hematotoxicity. We analyzed one or more single nucleotide polymorphisms (SNPs) in each of seven candidate genes (WRN, TP53, NBS1, BRCA1, BRCA2, XRCC3 and XRCC4) in a study of 250 workers exposed to benzene and 140 controls in China. Four SNPs in WRN (Ex4 -16 G > A, Ex6 +9 C > T, Ex20 -88 G > T and Ex26 -12 T > G), one SNP in TP53 (Ex4 +119 C > G) and one SNP in BRCA2 (Ex11 +1487 A > G) were associated with a statistically significant decrease in total white blood cell (WBC) counts among exposed workers. The SNPs in WRN and TP53 remained significant after accounting for multiple comparisons. One or more SNPs in WRN had broad effects on WBC subtypes, with significantly decreased granulocyte, total lymphocyte, CD4(+)-T cell, CD8(+)-T cell and monocyte counts. Haplotypes of WRN were associated with decreased WBC counts among benzene-exposed subjects. Likewise, subjects with TP53 Ex4 +119 C > G variant had reduced granulocyte, CD4(+)-T cell and B cell counts. The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity. JF - Carcinogenesis AU - Shen, Min AU - Lan, Qing AU - Zhang, Luoping AU - Chanock, Stephen AU - Li, Guilan AU - Vermeulen, Roel AU - Rappaport, Stephen M AU - Guo, Weihong AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Yeager, Meredith AU - Welch, Robert AU - Forrest, Matthew S AU - Rothman, Nathaniel AU - Smith, Martyn T AD - Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA. shenmi@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2083 EP - 2089 VL - 27 IS - 10 SN - 0143-3334, 0143-3334 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Benzene KW - J64922108F KW - Index Medicus KW - Cross-Sectional Studies KW - Haplotypes KW - Genes, p53 KW - Humans KW - Adult KW - Genes, BRCA2 KW - DNA Helicases -- genetics KW - Male KW - Female KW - DNA Repair -- genetics KW - Polymorphism, Single Nucleotide KW - Benzene -- toxicity KW - Genetic Predisposition to Disease KW - Blood Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68898623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+genes+involved+in+DNA+double-strand+break+repair+pathway+and+susceptibility+to+benzene-induced+hematotoxicity.&rft.au=Shen%2C+Min%3BLan%2C+Qing%3BZhang%2C+Luoping%3BChanock%2C+Stephen%3BLi%2C+Guilan%3BVermeulen%2C+Roel%3BRappaport%2C+Stephen+M%3BGuo%2C+Weihong%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BForrest%2C+Matthew+S%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T&rft.aulast=Shen&rft.aufirst=Min&rft.date=2006-10-01&rft.volume=27&rft.issue=10&rft.spage=2083&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Purification, crystallization and preliminary X-ray diffraction analysis of the phage T4 vertex protein gp24 and its mutant forms. AN - 68896178; 16884923 AB - The study of bacteriophage T4 assembly has revealed regulatory mechanisms pertinent not only to viruses but also to macromolecular complexes. The capsid of bacteriophage T4 is composed of the major capsid protein gp23, and a minor capsid protein gp24, which is arranged as pentamers at the vertices of the capsid. In this study the T4 capsid protein gp24 and its mutant forms were overexpressed and purified to homogeneity. The overexpression from plasmid vectors of all the constructs in Escherichia coli yields biologically active protein in vivo as determined by assembly of active virus following infection with inactivated gene 24 mutant viruses. The gp24 mutant was subjected to surface entropy reduction by mutagenesis and reductive alkylation in order to improve its crystallization properties and diffraction quality. To determine if surface mutagenesis targeting would result in diffractable crystals, two glutamate to alanine mutations (E89A,E90A) were introduced. We report here the biochemical observations and consequent mutagenesis experiment that resulted in improvements in the stability, crystallizability and crystal quality of gp24 without affecting the overall folding. Rational modification of the protein surface to achieve crystallization appears promising for improving crystallization behavior and crystal diffracting qualities. The crystal of gp24(E89A,E90A) diffracted to 2.6A resolution compared to wild-type gp24 at 3.80A resolution under the same experimental conditions. Surface mutation proved to be a better method than reductive methylation for improving diffraction quality of the gp24 crystals. JF - Protein expression and purification AU - Boeshans, Karen M AU - Liu, Fang AU - Peng, Guihong AU - Idler, William AU - Jang, Shyh-Ing AU - Marekov, Lyuben AU - Black, Lindsay AU - Ahvazi, Bijan AD - X-ray Crystallography Facility/Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8024, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 235 EP - 243 VL - 49 IS - 2 SN - 1046-5928, 1046-5928 KW - Capsid Proteins KW - 0 KW - gene 24 protein, Enterobacteria phage T4 KW - Index Medicus KW - Virus Assembly -- physiology KW - Protein Structure, Tertiary KW - Crystallography, X-Ray -- methods KW - Capsid Proteins -- isolation & purification KW - Escherichia coli -- genetics KW - Mutation, Missense KW - Capsid Proteins -- genetics KW - Capsid Proteins -- chemistry KW - Amino Acid Substitution KW - Capsid Proteins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68896178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+expression+and+purification&rft.atitle=Purification%2C+crystallization+and+preliminary+X-ray+diffraction+analysis+of+the+phage+T4+vertex+protein+gp24+and+its+mutant+forms.&rft.au=Boeshans%2C+Karen+M%3BLiu%2C+Fang%3BPeng%2C+Guihong%3BIdler%2C+William%3BJang%2C+Shyh-Ing%3BMarekov%2C+Lyuben%3BBlack%2C+Lindsay%3BAhvazi%2C+Bijan&rft.aulast=Boeshans&rft.aufirst=Karen&rft.date=2006-10-01&rft.volume=49&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Protein+expression+and+purification&rft.issn=10465928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postnatal inflammatory rat model for cerebral palsy: too different from humans. AN - 68890233; 17000237 AB - In humans, cerebral palsy (CP) may originate from inflammation during the second and third trimesters of gestation when preoligodendrocytes (Pre-OL) are most vulnerable to an inflammatory insult. We studied a postnatal CP model to evaluate injury that would correlate with presence of Pre-OL in human pregnancy. On postnatal (P) days 2, 3, 4, 5 and 6, pups were treated with (lipopolysaccharide [LPS]) (n = 7; 30, 30, 60, 60, 120 microg/Kg) or saline (n = 7). Neonates were tested for motor and cognitive development. Adult offspring performed beam walking and rotarod for motor activity. White matter damage was assessed with immunohistochemical Pre-OL markers (CNP, PLP). Statistical analysis included Mann-Whitney U and analysis of variance. LPS-treated animals performed negative geotaxis (P = .009) and surface righting (P = .01) earlier than controls. No differences were observed for other neonatal tests. Adult LPS-treated offspring performed better in tests of motor control: rotarod (P = .01) and beam walking (P = .02). Pre-OL markers were altered in LPS-treated animals at both P22 (CNP and PLP increased in LPS, P < .01 and P < .001, respectively) and 12 weeks (CNP and PLP decreased in LPS, P < .0001 and P < .03, respectively). Neonatal exposure to LPS induced white matter damage in the brain, accelerated neurodevelopment and motor tasks in adulthood. These are similar to findings from a postnatal hypoxic model suggesting that in the rodent, targeting the Pre-OL does not result in a CP phenotype. JF - American journal of obstetrics and gynecology AU - Roberson, Robin AU - Woodard, Jade E AU - Toso, Laura AU - Abebe, Daniel AU - Poggi, Sarah H AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1038 EP - 1044 VL - 195 IS - 4 KW - Lipopolysaccharides KW - 0 KW - Myelin Proteolipid Protein KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases KW - EC 3.1.4.- KW - Abridged Index Medicus KW - Index Medicus KW - Myelin Proteolipid Protein -- analysis KW - Animals KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases -- analysis KW - Humans KW - Behavior, Animal KW - Pregnancy KW - Rats KW - Animals, Newborn KW - Rats, Inbred F344 KW - Lipopolysaccharides -- toxicity KW - Species Specificity KW - Immunohistochemistry KW - Female KW - Disease Models, Animal KW - Inflammation -- complications KW - Cerebral Palsy -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68890233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Postnatal+inflammatory+rat+model+for+cerebral+palsy%3A+too+different+from+humans.&rft.au=Roberson%2C+Robin%3BWoodard%2C+Jade+E%3BToso%2C+Laura%3BAbebe%2C+Daniel%3BPoggi%2C+Sarah+H%3BSpong%2C+Catherine+Y&rft.aulast=Roberson&rft.aufirst=Robin&rft.date=2006-10-01&rft.volume=195&rft.issue=4&rft.spage=1038&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. AN - 68887125; 16807375 AB - Nicotinamide adenine dinucleotide (NAD) plays a critical role in the maintenance of cellular energy homeostasis. alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is the key enzyme regulating de novo synthesis of NAD from l-tryptophan (Trp), designated the Trp-NAD pathway. Acmsd gene expression was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxisome proliferator-activated receptor alpha (PPARalpha). Constitutive expression of ACMSD mRNA levels were governed by HNF4alpha and downregulated by activation of PPARalpha by the ligand Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid]), as revealed by studies with hepatic HNF4alpha-null mice and PPARalpha-null mice, respectively. Transient transfection and electrophoretic mobility shift analyses showed an HNF4alpha binding site in the Acmsd gene promoter that directed transactivation of reporter gene constructs by HNF4alpha. The Acmsd promoter was not responsive to PPARalpha in transactivation assays. Wy-14,643 treatment decreased HNF4alpha protein levels in wild-type, but not PPARalpha-null, mouse livers, with no changes in HNF4alpha mRNA. These results show that Wy-14,643, through PPARalpha, post-transcriptionally down-regulates HNF4alpha protein levels, leading to reduced expression of the HNF4alpha target gene Acmsd. JF - Molecular pharmacology AU - Shin, Mariko AU - Kim, Insook AU - Inoue, Yusuke AU - Kimura, Shioko AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Building 37, Room 3106, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1281 EP - 1290 VL - 70 IS - 4 SN - 0026-895X, 0026-895X KW - Hepatocyte Nuclear Factor 4 KW - 0 KW - PPAR alpha KW - Peroxisome Proliferators KW - Pyrimidines KW - NAD KW - 0U46U6E8UK KW - pirinixic acid KW - 86C4MRT55A KW - Tryptophan KW - 8DUH1N11BX KW - Carboxy-Lyases KW - EC 4.1.1.- KW - aminocarboxymuconate-semialdehyde decarboxylase KW - EC 4.1.1.45 KW - Index Medicus KW - Transcription Initiation Site KW - Animals KW - Humans KW - Peroxisome Proliferators -- pharmacology KW - Pyrimidines -- pharmacology KW - Mice KW - Tryptophan -- metabolism KW - Mice, Transgenic KW - Binding Sites KW - Base Sequence KW - Promoter Regions, Genetic KW - Transfection KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Signal Transduction KW - NAD -- metabolism KW - Liver -- enzymology KW - Gene Expression Regulation, Enzymologic KW - Hepatocyte Nuclear Factor 4 -- physiology KW - Hepatocyte Nuclear Factor 4 -- genetics KW - PPAR alpha -- physiology KW - Carboxy-Lyases -- genetics KW - Hepatocyte Nuclear Factor 4 -- metabolism KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68887125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Regulation+of+mouse+hepatic+alpha-amino-beta-carboxymuconate-epsilon-semialdehyde+decarboxylase%2C+a+key+enzyme+in+the+tryptophan-nicotinamide+adenine+dinucleotide+pathway%2C+by+hepatocyte+nuclear+factor+4alpha+and+peroxisome+proliferator-activated+receptor+alpha.&rft.au=Shin%2C+Mariko%3BKim%2C+Insook%3BInoue%2C+Yusuke%3BKimura%2C+Shioko%3BGonzalez%2C+Frank+J&rft.aulast=Shin&rft.aufirst=Mariko&rft.date=2006-10-01&rft.volume=70&rft.issue=4&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-29 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxins in the treatment of refractory hairy cell leukemia. AN - 68886281; 16990113 AB - An increasing number of patients who have hairy cell leukemia (HCL) have persistent disease that requires treatment, despite purine analogs, splenectomy, interferon, and rituximab. Many of these patients have been treated successfully with immunotoxins. An immunotoxin contains a protein toxin connected to a cell-binding ligand, such as an antibody. An immunotoxin recognizes the target cell, internalizes, and the toxin translocates to the cytosol where it inhibits protein synthesis enzymatically. Immunotoxins that show activity in HCL contain truncated Psedomonas exotoxin fused to the Fv fragments of anti-CD25 or anti-CD22 monoclonal antibodies. Both agents, termed LMB-2 and BL22, respectively, have been tested in patients who have HCL after failure of purine analogs and other therapies; major responses have been achieved in most patients. JF - Hematology/oncology clinics of North America AU - Kreitman, Robert J AU - Pastan, Ira AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124b, Bethesda, MD 20892-4255, USA. kreitmar@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1137 EP - 51, viii VL - 20 IS - 5 SN - 0889-8588, 0889-8588 KW - Antibodies, Monoclonal KW - 0 KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Bacterial Toxins KW - Exotoxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Receptors, Interleukin-2 KW - Sialic Acid Binding Ig-like Lectin 2 KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Disease-Free Survival KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Clinical Trials as Topic KW - Remission Induction -- methods KW - Receptors, Interleukin-2 -- immunology KW - Leukemia, Hairy Cell -- mortality KW - ADP Ribose Transferases -- immunology KW - Virulence Factors -- therapeutic use KW - Immunoglobulin Variable Region -- immunology KW - Bacterial Toxins -- immunology KW - Exotoxins -- immunology KW - Virulence Factors -- immunology KW - Immunoglobulin Variable Region -- therapeutic use KW - ADP Ribose Transferases -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Bacterial Toxins -- therapeutic use KW - Leukemia, Hairy Cell -- drug therapy KW - Immunotoxins -- therapeutic use KW - Exotoxins -- therapeutic use KW - Leukemia, Hairy Cell -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68886281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology%2Foncology+clinics+of+North+America&rft.atitle=Immunotoxins+in+the+treatment+of+refractory+hairy+cell+leukemia.&rft.au=Kreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=20&rft.issue=5&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Hematology%2Foncology+clinics+of+North+America&rft.issn=08898588&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. AN - 68884883; 16837625 AB - The ATP-driven drug export pump, P-glycoprotein, is a primary gatekeeper of the blood-brain barrier and a major impediment to central nervous system (CNS) pharmacotherapy. Reducing P-glycoprotein activity dramatically increases penetration of many therapeutic drugs into the CNS. Previous studies in rat showed that brain capillary P-glycoprotein was transcriptionally up-regulated by the pregnane X receptor (PXR), a xenobiotic-activated nuclear receptor. Here we used a transgenic mouse expressing human PXR (hPXR) to determine the consequences of increased blood-brain barrier P-glycoprotein activity. P-glycoprotein expression and transport activity in brain capillaries from transgenic mice was significantly increased when capillaries were exposed to the hPXR ligands, rifampin and hyperforin, in vitro and when the mice were dosed with rifampin in vivo. Plasma rifampin levels in induced mice were comparable with literature values for patients. We also administered methadone, a CNS-acting, P-glycoprotein substrate, to control and rifampin-induced transgenic mice and measured the drug's antinociceptive effect. In rifampin-induced mice, the methadone effect was reduced by approximately 70%, even though plasma methadone levels were similar to those found in transgenic controls not exposed to rifampin. Thus, hPXR activation in vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing the drug's CNS efficacy. This is the first demonstration of the ability of blood-brain barrier PXR to alter the efficacy of a CNS-acting drug. JF - Molecular pharmacology AU - Bauer, Björn AU - Yang, Xiaodong AU - Hartz, Anika M S AU - Olson, Emily R AU - Zhao, Rong AU - Kalvass, J Cory AU - Pollack, Gary M AU - Miller, David S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1212 EP - 1219 VL - 70 IS - 4 SN - 0026-895X, 0026-895X KW - Analgesics KW - 0 KW - P-Glycoprotein KW - P-Glycoproteins KW - Receptors, Steroid KW - multidrug resistance protein 3 KW - pregnane X receptor KW - Methadone KW - UC6VBE7V1Z KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Brain -- blood supply KW - Humans KW - Rifampin -- pharmacokinetics KW - Analgesics -- pharmacology KW - Brain -- metabolism KW - Mice KW - Mice, Transgenic KW - P-Glycoproteins -- genetics KW - In Vitro Techniques KW - ATP-Binding Cassette Transporters -- genetics KW - Mice, Inbred C57BL KW - Rifampin -- pharmacology KW - Male KW - Receptors, Steroid -- physiology KW - P-Glycoprotein -- metabolism KW - Receptors, Steroid -- metabolism KW - Methadone -- pharmacokinetics KW - Up-Regulation KW - Receptors, Steroid -- genetics KW - Methadone -- metabolism KW - Methadone -- pharmacology KW - Blood-Brain Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68884883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=In+vivo+activation+of+human+pregnane+X+receptor+tightens+the+blood-brain+barrier+to+methadone+through+P-glycoprotein+up-regulation.&rft.au=Bauer%2C+Bj%C3%B6rn%3BYang%2C+Xiaodong%3BHartz%2C+Anika+M+S%3BOlson%2C+Emily+R%3BZhao%2C+Rong%3BKalvass%2C+J+Cory%3BPollack%2C+Gary+M%3BMiller%2C+David+S&rft.aulast=Bauer&rft.aufirst=Bj%C3%B6rn&rft.date=2006-10-01&rft.volume=70&rft.issue=4&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-29 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. AN - 68875600; 16857745 AB - To identify the potential functions of peroxisome proliferator-activated receptor alpha (PPARalpha) in skin development, transgenic mice were generated to target constitutively activated PPARalpha (VP16PPARalpha) to the stratified epithelia by use of the keratin K5 promoter. In addition to marked alterations in epidermal development, the transgenic mice had a severe defect in lactation during pregnancy resulting in 100% pup mortality. In this study, the alteration of mammary gland development in these transgenic mice was investigated. The results showed that expression of the VP16PPARalpha transgene during pregnancy resulted in impaired development of lobuloalveoli, which is associated with reduced proliferation and increased apoptosis of mammary epithelia. Mammary epithelia from transgenic mice also showed a significant reduction in the expression of beta-catenin and a down-regulation of one of its target genes, cyclin D1, which is thought to be required for lobuloalveolar development. Furthermore, upon PPARalpha ligand treatment, similar effects on lobuloalveolar development were observed in wild-type mice, but not in PPARalpha-null mice. These findings suggest that PPARalpha activation has a marked influence in mammary lobuloalveolar development. JF - Endocrinology AU - Yang, Qian AU - Kurotani, Reiko AU - Yamada, Atsushi AU - Kimura, Shioko AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 4772 EP - 4780 VL - 147 IS - 10 SN - 0013-7227, 0013-7227 KW - Caseins KW - 0 KW - Coloring Agents KW - Fluorescent Dyes KW - PPAR alpha KW - Pyrimidines KW - beta Catenin KW - Cyclin D1 KW - 136601-57-5 KW - pirinixic acid KW - 86C4MRT55A KW - Eosine Yellowish-(YS) KW - TDQ283MPCW KW - Hematoxylin KW - YKM8PY2Z55 KW - Abridged Index Medicus KW - Index Medicus KW - Promoter Regions, Genetic -- physiology KW - Lactation -- physiology KW - Animals KW - beta Catenin -- biosynthesis KW - Blotting, Northern KW - Apoptosis -- physiology KW - Survival KW - Pyrimidines -- pharmacology KW - Mice KW - Cyclin D1 -- biosynthesis KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Cell Proliferation KW - Animals, Newborn -- physiology KW - Caseins -- biosynthesis KW - Caseins -- genetics KW - Immunohistochemistry KW - Female KW - PPAR alpha -- drug effects KW - Mammary Glands, Animal -- physiology KW - Pregnancy -- physiology KW - Mammary Glands, Animal -- growth & development KW - PPAR alpha -- physiology KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68875600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Peroxisome+proliferator-activated+receptor+alpha+activation+during+pregnancy+severely+impairs+mammary+lobuloalveolar+development+in+mice.&rft.au=Yang%2C+Qian%3BKurotani%2C+Reiko%3BYamada%2C+Atsushi%3BKimura%2C+Shioko%3BGonzalez%2C+Frank+J&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2006-10-01&rft.volume=147&rft.issue=10&rft.spage=4772&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2005 May;19(5):1135-46 [15661831] Development. 2005 Jan;132(2):267-77 [15590737] J Biol Chem. 2005 Oct 28;280(43):36301-9 [16120603] Endocr Rev. 2005 Dec;26(7):898-915 [16126938] Vet Pathol. 2006 Jan;43(1):36-49 [16407485] Nat Rev Mol Cell Biol. 2005 Sep;6(9):715-25 [16231422] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5522-7 [10318916] Nature. 1999 Apr 1;398(6726):422-6 [10201372] Biochem Biophys Res Commun. 1998 Dec 30;253(3):813-7 [9918810] J Invest Dermatol. 1998 Dec;111(6):1116-21 [9856826] Carcinogenesis. 1998 Nov;19(11):1989-94 [9855014] J Invest Dermatol. 1998 Sep;111(3):429-33 [9740236] Cell. 2000 Sep 29;103(1):41-50 [11051546] J Invest Dermatol. 2000 Nov;115(5):788-94 [11069615] J Biol Chem. 2000 Sep 1;275(35):27117-22 [10852923] Science. 2000 Aug 11;289(5481):950-3 [10937998] J Med Chem. 2000 Feb 24;43(4):527-50 [10691680] Cancer Res. 1999 Nov 15;59(22):5671-3 [10582681] J Invest Dermatol. 1999 Nov;113(5):788-95 [10571735] J Invest Dermatol. 2006 Feb;126(2):374-85 [16374467] Anticancer Res. 2001 Mar-Apr;21(2A):825-9 [11396171] Endocrinology. 2001 Oct;142(10):4195-202 [11564675] J Cell Biol. 2001 Dec 10;155(6):1055-64 [11739413] J Biol Chem. 2002 Feb 15;277(7):5339-44 [11726661] Int J Dev Biol. 2002 Jan;46(1):105-14 [11902671] Mol Endocrinol. 2002 May;16(5):1013-28 [11981036] Mol Endocrinol. 2002 May;16(5):1029-39 [11981037] Endocrinology. 2002 Nov;143(11):4358-65 [12399432] Dev Cell. 2002 Dec;3(6):877-87 [12479812] J Cell Sci. 2003 Mar 15;116(Pt 6):1137-49 [12584256] Breast Cancer Res Treat. 2003 Mar;78(2):179-92 [12725418] J Lipid Res. 2003 Jun;44(6):1100-12 [12700340] Oncogene. 2003 Aug 21;22(35):5415-26 [12934101] J Invest Dermatol. 2004 Apr;122(4):971-83 [15102088] Carcinogenesis. 2004 Sep;25(9):1747-55 [15073042] J Biol Chem. 2004 Oct 22;279(43):45020-7 [15308623] Nature. 1990 Oct 18;347(6294):645-50 [2129546] Nature. 1992 Jan 30;355(6359):446-9 [1310351] Cell. 1992 Mar 6;68(5):879-87 [1312391] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547-51 [1319065] Nature. 1992 Aug 27;358(6389):771-4 [1324435] Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4 [8384714] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9 [8041794] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Science. 1995 Jun 23;268(5218):1766-9 [7792603] Cell. 1995 Aug 25;82(4):621-30 [7664341] Genes Dev. 1995 Oct 1;9(19):2364-72 [7557388] Endocrinology. 1996 Jan;137(1):354-66 [8536636] Development. 1996 Dec;122(12):4013-22 [9012521] J Clin Invest. 1997 Aug 1;100(3):705-12 [9239419] J Biol Chem. 1997 Oct 24;272(43):27307-12 [9341179] J Invest Dermatol. 1998 Apr;110(4):368-75 [9540977] Genes Dev. 1998 Jun 15;12(12):1917-28 [9637692] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking. AN - 68868839; 16341024 AB - Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated context, following extinction of operant responding in a different context, reinstates heroin seeking. In an initial pharmacological characterization, we found that the mGluR2/3 agonist LY379268, which acts centrally to reduce evoked glutamate release, attenuates context-induced reinstatement of heroin seeking when injected systemically or into the ventral tegmental area, the cell body region of the mesolimbic dopamine system. Here, we tested whether injections of LY379268 into the nucleus accumbens (NAc), a terminal region of the mesolimbic dopamine system, would also attenuate context-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin; drug infusions were paired with a discrete tone-light cue. Subsequently, lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. After extinction of responding, LY379268 was injected to different groups of rats into the NAc core or shell or into the caudate-putamen, a terminal region of the nigrastriatal dopamine system. Injections of LY379268 into the NAc shell (0.3 or 1.0 microg) dose-dependently attenuated context-induced reinstatement of heroin seeking. Injections of 1.0 microg of LY379268 into the NAc core had no effect, while a higher dose (3.0 microg) decreased this reinstatement. Injections of LY379268 (3.0 microg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Bossert, Jennifer M AU - Gray, Sarah M AU - Lu, Lin AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD 21224, USA. jbossert@intra.nida.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2197 EP - 2209 VL - 31 IS - 10 SN - 0893-133X, 0893-133X KW - Amino Acids KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - LY 379268 KW - Narcotics KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor 2 KW - Heroin KW - 70D95007SX KW - Index Medicus KW - Amino Acids -- administration & dosage KW - Animals KW - Rats, Long-Evans KW - Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage KW - Dose-Response Relationship, Drug KW - Enzyme Activation -- physiology KW - Narcotics -- administration & dosage KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Enzyme Activation -- drug effects KW - Behavior, Animal -- physiology KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Heroin -- administration & dosage KW - Male KW - Conditioning, Operant -- drug effects KW - Nucleus Accumbens -- drug effects KW - Conditioning, Operant -- physiology KW - Nucleus Accumbens -- physiology KW - Heroin Dependence -- physiopathology KW - Heroin Dependence -- drug therapy KW - Receptors, Metabotropic Glutamate -- physiology KW - Receptors, Metabotropic Glutamate -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68868839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Activation+of+group+II+metabotropic+glutamate+receptors+in+the+nucleus+accumbens+shell+attenuates+context-induced+relapse+to+heroin+seeking.&rft.au=Bossert%2C+Jennifer+M%3BGray%2C+Sarah+M%3BLu%2C+Lin%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2006-10-01&rft.volume=31&rft.issue=10&rft.spage=2197&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2000 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U S A. 2000 Apr 11;97(8):4321-6 [10760299] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant. AN - 68852145; 16965994 AB - To determine the value of pulmonary function tests (PFTs) done before peripheral blood stem cell transplant (PBSCT) in predicting mortality after total body irradiation (TBI) performed with or without dose reduction to the lung. From 1997 to 2004, 146 consecutive patients with hematologic malignancies received fractionated TBI before PBSCT. With regimen A (n=85), patients were treated without lung dose reduction to 13.6 gray (Gy). In regimen B (n=35), total body dose was decreased to 12 Gy (1.5 Gy twice per day for 4 days) and lung dose was limited to 9 Gy by use of lung shielding. In regimen C (n=26), lung dose was reduced to 6 Gy. All patients received PFTs before treatment, 90 days after treatment, and annually. Median follow-up was 44 months (range, 12-90 months). Sixty-one patients had combined ventilation/diffusion capacity deficits defined as both a forced expiratory volume in the first second (FEV1) and a diffusion capacity of carbon dioxide (DLCO)<100% predicted. In this group, there was a 20% improvement in one-year overall survival with lung dose reduction (70 vs. 50%, log-rank test p=0.042). Among those with combined ventilation/diffusion capacity deficits, lung dose reduction during TBI significantly improved survival. JF - International journal of radiation oncology, biology, physics AU - Singh, Anurag K AU - Karimpour, Shervin E AU - Savani, Bipin N AU - Guion, Peter AU - Hope, Andrew J AU - Mansueti, John R AU - Ning, Holly AU - Altemus, Rosemary M AU - Wu, Colin O AU - Barrett, A John AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. singan@mail.nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 520 EP - 527 VL - 66 IS - 2 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Respiratory Function Tests KW - Transplantation Conditioning KW - Radiation Protection KW - Radiotherapy Dosage KW - Pulmonary Diffusing Capacity KW - Humans KW - Adult KW - Forced Expiratory Volume KW - Male KW - Female KW - Whole-Body Irradiation -- mortality KW - Hematopoietic Stem Cell Transplantation -- mortality KW - Hematologic Neoplasms -- physiopathology KW - Whole-Body Irradiation -- adverse effects KW - Hematologic Neoplasms -- surgery KW - Lung -- physiopathology KW - Lung -- radiation effects KW - Hematologic Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68852145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Pretransplant+pulmonary+function+tests+predict+risk+of+mortality+following+fractionated+total+body+irradiation+and+allogeneic+peripheral+blood+stem+cell+transplant.&rft.au=Singh%2C+Anurag+K%3BKarimpour%2C+Shervin+E%3BSavani%2C+Bipin+N%3BGuion%2C+Peter%3BHope%2C+Andrew+J%3BMansueti%2C+John+R%3BNing%2C+Holly%3BAltemus%2C+Rosemary+M%3BWu%2C+Colin+O%3BBarrett%2C+A+John&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-10-01&rft.volume=66&rft.issue=2&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. AN - 68849247; 16757181 AB - The response to drugs is affected by expectation, which in turn is sensitive to prior drug experiences. Here, we evaluate the effects of expectation on the responses to intravenous methylphenidate (0.5 mg/kg) in fifteen subjects who had minimal experience with stimulant drugs. We used positron emission tomography to measure brain glucose metabolism, which we used as a marker of brain function and tested them under four randomized conditions (1) expecting placebo and receiving placebo; (2) expecting placebo and receiving methylphenidate; (3) expecting methylphenidate and receiving methylphenidate; (4) expecting methylphenidate and receiving placebo. We show that methylphenidate-induced decreases in striatum were greater when subjects expected to receive methylphenidate than when they were not expecting it. We also show that the subjects' expectations affected their responses to placebo. That is, when subjects expected to receive methylphenidate but received placebo there were significant increases in ventral cingulate gyrus (BA 25) and nucleus accumbens (regions involved with emotional reactivity and reward). The effect was largest in subjects who, because of experimental randomization, had not experienced methylphenidate. Because subjects were told that methylphenidate could be experienced as pleasant, unpleasant or devoid of subjective effects these results suggest the involvement of the ventral cingulate and of the nucleus accumbens in processing expectation for "uncertain drug effects". Thus, the state of expectation needs to be considered as a variable modulating the reinforcing and therapeutic effects of drugs even in subjects who have no prior experience with the drug. JF - NeuroImage AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Ma, Yeming AU - Fowler, Joanna S AU - Wong, Christopher AU - Jayne, Millard AU - Telang, Frank AU - Swanson, James M AD - National Institute on Drug Abuse, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 1782 EP - 1792 VL - 32 IS - 4 SN - 1053-8119, 1053-8119 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Radiopharmaceuticals KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Prefrontal Cortex -- diagnostic imaging KW - Set (Psychology) KW - Prefrontal Cortex -- metabolism KW - Humans KW - Dopamine -- physiology KW - Neostriatum -- diagnostic imaging KW - Heart Rate -- drug effects KW - Placebo Effect KW - Reward KW - Adult KW - Neostriatum -- drug effects KW - Heart Rate -- physiology KW - Male KW - Blood Pressure -- physiology KW - Positron-Emission Tomography KW - Gyrus Cinguli -- diagnostic imaging KW - Gyrus Cinguli -- drug effects KW - Brain -- diagnostic imaging KW - Prefrontal Cortex -- drug effects KW - Neostriatum -- metabolism KW - Gyrus Cinguli -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Blood Pressure -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- pharmacology KW - Brain Chemistry -- drug effects KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68849247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Effects+of+expectation+on+the+brain+metabolic+responses+to+methylphenidate+and+to+its+placebo+in+non-drug+abusing+subjects.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMa%2C+Yeming%3BFowler%2C+Joanna+S%3BWong%2C+Christopher%3BJayne%2C+Millard%3BTelang%2C+Frank%3BSwanson%2C+James+M&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2006-10-01&rft.volume=32&rft.issue=4&rft.spage=1782&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. AN - 68839864; 16854249 AB - The purpose of this study was to present 12-month and lifetime estimates of the prevalence, sociodemographic and clinical correlates, and psychiatric co-morbidity of DSM-IV cannabis abuse and dependence. Data were derived from a large nationally representative survey (n=43093) of US adults. The prevalence of 12-month and lifetime DSM-IV cannabis abuse (1.1% and 7.2%) exceeded the corresponding rates of cannabis dependence (0.3% and 1.3%). Being male, Native American, widowed/separated/divorced, and residing in the West increased the odds whereas being Black, Asian or Hispanic decreased the odds of cannabis abuse and dependence. Cannabis dependence was significantly associated with low income. Ages of onset for both cannabis use disorders occurred in adolescence and the majority of individuals with these disorders remained untreated. Co-morbidity was high between cannabis use disorders and other Axis I and II disorders. Cannabis use disorders continue to present a widespread and serious personal and public health problem. Native Americans were found to have high rates of cannabis use disorders, warranting closer attention to the mental health needs of this subgroup. Associations between cannabis abuse and dependence and Axis I and II disorders were strong, signaling the need for more comprehensive assessment of individuals with cannabis use disorders. Further controlled treatment studies are needed, especially among co-morbid individuals, in view of growing evidence of the adverse personal, medical and societal impacts of cannabis use disorders in the USA. JF - Psychological medicine AU - Stinson, Frederick S AU - Ruan, W June AU - Pickering, Roger AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1447 EP - 1460 VL - 36 IS - 10 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - United States KW - Age of Onset KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Comorbidity KW - Prevalence KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Marijuana Abuse -- diagnosis KW - Marijuana Abuse -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Cannabis+use+disorders+in+the+USA%3A+prevalence%2C+correlates+and+co-morbidity.&rft.au=Stinson%2C+Frederick+S%3BRuan%2C+W+June%3BPickering%2C+Roger%3BGrant%2C+Bridget+F&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=2006-10-01&rft.volume=36&rft.issue=10&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-24 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - International collaboration on alcoholic liver disease and pancreatitis: opportunities. AN - 68834600; 16958660 JF - Journal of gastroenterology and hepatology AU - Purohit, Vishnudutt AD - Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. vpurohit@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - S107 EP - S108 VL - 21 Suppl 3 SN - 0815-9319, 0815-9319 KW - Index Medicus KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Pancreatitis, Alcoholic -- prevention & control KW - Liver Diseases, Alcoholic -- prevention & control KW - International Cooperation KW - Research Support as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68834600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=International+collaboration+on+alcoholic+liver+disease+and+pancreatitis%3A+opportunities.&rft.au=Purohit%2C+Vishnudutt&rft.aulast=Purohit&rft.aufirst=Vishnudutt&rft.date=2006-10-01&rft.volume=21+Suppl+3&rft.issue=&rft.spage=S107&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. AN - 68831459; 16766576 AB - Neutrophil recruitment to the lung after lipopolysaccharide (LPS; endotoxin) inhalation is primarily dependent on Toll-like receptor 4 (Tlr4) signaling, because it is virtually absent in mice deficient in Tlr4. However, among strains wild type for Tlr4, the magnitude of neutrophil recruitment to the lung after LPS inhalation is variable, suggesting the involvement of genes other than Tlr4. To identify genes associated with the inflammatory response to inhaled LPS, we evaluated the transcriptional response in lungs of 12 inbred strains of mice, 8 which are wild type for Tlr4 and 4 of which lack functional Tlr4. Using the promoter integration in microarray analysis algorithm, we scanned our gene list for transcription factor-binding sites significantly overrepresented among Tlr4 wild-type strains with high neutrophil influx in the lung after LPS inhalation. This analysis identified the interferon (IFN)-stimulated response element (ISRE) as the most overrepresented transcription factor (present in 24% of the promoters) associated with the neutrophil influx to the lower respiratory tract. To test the validity of this observation, we evaluated IFN-gamma-deficient mice and found that the presence of IFN-gamma is essential for robust neutrophil recruitment to the lower respiratory tract and modulation of key regulatory cytokines and chemokines after LPS inhalation. In conclusion, using a genomic approach, we identified the ISRE as a transcriptional element associated with the neutrophil response to inhaled LPS and demonstrated for the first time that IFN-gamma plays a critical role in LPS-induced neutrophil recruitment to the lower airways. JF - American journal of physiology. Lung cellular and molecular physiology AU - Burch, Lauranell H AU - Yang, Ivana V AU - Whitehead, Gregory S AU - Chao, Frank G AU - Berman, Katherine G AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Division of Pulmonary, Allergy, and Critical Care Medicine, Research Triangle Park, NC 27709, USA. burchl@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - L677 EP - L682 VL - 291 IS - 4 SN - 1040-0605, 1040-0605 KW - Lipopolysaccharides KW - 0 KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Transcription Factors KW - Interferon-gamma KW - 82115-62-6 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Gene Expression -- drug effects KW - Transcription Factors -- physiology KW - Animals KW - Pneumonia -- chemically induced KW - Pneumonia -- genetics KW - Mice KW - Response Elements -- physiology KW - Mice, Knockout KW - Mice, Inbred Strains KW - Interferons -- physiology KW - Toll-Like Receptor 4 -- deficiency KW - Toll-Like Receptor 4 -- physiology KW - Administration, Inhalation KW - Male KW - Lipopolysaccharides -- administration & dosage KW - Transcription, Genetic -- drug effects KW - Neutrophil Infiltration -- genetics KW - Lipopolysaccharides -- pharmacology KW - Lung -- drug effects KW - Neutrophil Infiltration -- physiology KW - Interferon-gamma -- physiology KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68831459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=The+transcriptional+response+to+lipopolysaccharide+reveals+a+role+for+interferon-gamma+in+lung+neutrophil+recruitment.&rft.au=Burch%2C+Lauranell+H%3BYang%2C+Ivana+V%3BWhitehead%2C+Gregory+S%3BChao%2C+Frank+G%3BBerman%2C+Katherine+G%3BSchwartz%2C+David+A&rft.aulast=Burch&rft.aufirst=Lauranell&rft.date=2006-10-01&rft.volume=291&rft.issue=4&rft.spage=L677&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Special remarks from the National Institute on Alcohol Abuse and Alcoholism. AN - 68829986; 16958664 JF - Journal of gastroenterology and hepatology AU - Zakhari, Samir AD - Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. szakhari@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1 VL - 21 Suppl 3 SN - 0815-9319, 0815-9319 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Biomedical Research KW - Humans KW - United States -- epidemiology KW - Societies, Medical KW - Comorbidity KW - Liver Diseases, Alcoholic -- therapy KW - Pancreatitis, Alcoholic -- therapy KW - Pancreatitis, Alcoholic -- mortality KW - Ethanol -- pharmacology KW - Liver Diseases, Alcoholic -- mortality KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68829986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Special+remarks+from+the+National+Institute+on+Alcohol+Abuse+and+Alcoholism.&rft.au=Zakhari%2C+Samir&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2006-10-01&rft.volume=21+Suppl+3&rft.issue=&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation. AN - 68829285; 16960790 AB - Combination antifungal therapy is increasingly used in the treatment of invasive aspergillosis. Whether the interaction between amphotericin B and triazoles is antagonistic against invasive aspergillosis is a controversial issue that is not likely to be resolved through a randomized clinical trial. Here, we found both in vitro and in vivo antagonism between liposomal amphotericin B and ravuconazole in simultaneous treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits. Bliss independence-based drug-interaction modeling showed significant antagonism in vitro and in vivo, with the observed drug effects being 20%-69% lower than would be expected if the drugs were acting independently. These in vitro and in vivo findings of antagonism were consistent with the findings from Loewe additivity-based drug-interaction modeling. No pharmacokinetic interaction was found. The combination of a triazole and polyene may be antagonistic in the treatment of invasive pulmonary aspergillosis. JF - The Journal of infectious diseases AU - Meletiadis, Joseph AU - Petraitis, Vidmantas AU - Petraitiene, Ruta AU - Lin, Pengxin AU - Stergiopoulou, Theodouli AU - Kelaher, Amy M AU - Sein, Tin AU - Schaufele, Robert L AU - Bacher, John AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 1008 EP - 1018 VL - 194 IS - 7 SN - 0022-1899, 0022-1899 KW - Antifungal Agents KW - 0 KW - ER 30346 KW - Liposomes KW - Polyenes KW - Thiazoles KW - Triazoles KW - liposomal amphotericin B KW - Amphotericin B KW - 7XU7A7DROE KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Humans KW - Polyenes -- antagonists & inhibitors KW - Rabbits KW - Polyenes -- pharmacology KW - Drug Antagonism KW - Polyenes -- therapeutic use KW - Models, Biological KW - Microbial Sensitivity Tests KW - Lung Diseases, Fungal -- drug therapy KW - Aspergillosis -- drug therapy KW - Liposomes -- pharmacology KW - Liposomes -- therapeutic use KW - Triazoles -- pharmacology KW - Antifungal Agents -- therapeutic use KW - Thiazoles -- pharmacology KW - Antifungal Agents -- antagonists & inhibitors KW - Antifungal Agents -- pharmacology KW - Triazoles -- antagonists & inhibitors KW - Amphotericin B -- antagonists & inhibitors KW - Aspergillus fumigatus -- drug effects KW - Triazoles -- therapeutic use KW - Amphotericin B -- pharmacology KW - Thiazoles -- antagonists & inhibitors KW - Liposomes -- antagonists & inhibitors KW - Thiazoles -- therapeutic use KW - Amphotericin B -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68829285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Triazole-polyene+antagonism+in+experimental+invasive+pulmonary+aspergillosis%3A+in+vitro+and+in+vivo+correlation.&rft.au=Meletiadis%2C+Joseph%3BPetraitis%2C+Vidmantas%3BPetraitiene%2C+Ruta%3BLin%2C+Pengxin%3BStergiopoulou%2C+Theodouli%3BKelaher%2C+Amy+M%3BSein%2C+Tin%3BSchaufele%2C+Robert+L%3BBacher%2C+John%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-10-01&rft.volume=194&rft.issue=7&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains. AN - 68816880; 16777093 AB - We have previously shown that immunization with RPE65 produces in rats of four strains a severe inflammatory eye disease, designated experimental autoimmune uveitis (EAU). Here, we examined the uveitogenicity of RPE65 in six strains of mice. Only one strain, C57Bl/6, was found to develop consistently moderate levels of EAU, whereas other strains (BALB/c, B10.A, B10.BR, B10.RIII, C57BL/10J) were found to be essentially resistant to disease induced by RPE65. Analysis of the expression of RPE65 mRNA in thymi of the six mouse strains revealed detectable levels of the transcript in all strains, but with remarkable quantitative differences, with the lowest levels seen in thymi of C57Bl/6 mice, the only strain susceptible to RPE65-induced EAU. Moreover, unlike the finding with the mice, no RPE65 mRNA was detected in thymi of any of the four rat strains (Lewis, BN, F344, SHR) all of which are susceptible to the disease. These data thus indicate that the susceptibility to RPE65-induced EAU is inversely related to the thymic expression of the molecule. The data also suggest that this disease can be induced only in mice in which thymic expression of RPE65 is sufficiently low to allow the escape from deletion of T-cells with the adequate capacity to initiate the pathogenic immune response. JF - Experimental eye research AU - Ham, Don-Il AU - Fujimoto, Chiaki AU - Gentleman, Susan AU - Chan, Chi-Chao AU - Yu, Cheng-Rong AU - Yu, Shirley AU - Egwuagu, Charles E AU - Michael Redmond, T AU - Gery, Igal AD - Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892-1857, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 897 EP - 902 VL - 83 IS - 4 SN - 0014-4835, 0014-4835 KW - Carrier Proteins KW - 0 KW - Eye Proteins KW - RNA, Messenger KW - retinoid isomerohydrolase KW - EC 3.1.1.64 KW - cis-trans-Isomerases KW - EC 5.2.- KW - Index Medicus KW - Animals KW - Disease Susceptibility KW - Gene Expression KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - RNA, Messenger -- genetics KW - Immune Tolerance KW - Rats KW - Rats, Inbred Strains KW - Mice, Inbred Strains KW - Species Specificity KW - Female KW - Thymus Gland -- immunology KW - Eye Proteins -- toxicity KW - Eye Proteins -- genetics KW - Thymus Gland -- metabolism KW - Autoimmune Diseases -- metabolism KW - Autoimmune Diseases -- chemically induced KW - Uveitis -- metabolism KW - Uveitis -- immunology KW - Eye Proteins -- biosynthesis KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=The+level+of+thymic+expression+of+RPE65+inversely+correlates+with+its+capacity+to+induce+experimental+autoimmune+uveitis+%28EAU%29+in+different+rodent+strains.&rft.au=Ham%2C+Don-Il%3BFujimoto%2C+Chiaki%3BGentleman%2C+Susan%3BChan%2C+Chi-Chao%3BYu%2C+Cheng-Rong%3BYu%2C+Shirley%3BEgwuagu%2C+Charles+E%3BMichael+Redmond%2C+T%3BGery%2C+Igal&rft.aulast=Ham&rft.aufirst=Don-Il&rft.date=2006-10-01&rft.volume=83&rft.issue=4&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=00144835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices. AN - 68745707; 16860439 AB - Glutamate receptor activated neuronal cell death is attributed to a massive influx of Ca(2+) and subsequent formation of reactive oxygen species (ROS) but the relative contribution of NMDA and non-NMDA sub-types of glutamate receptors in excitotoxicity is not known. In the present study, we have examined the role of NMDA and non-NMDA receptors in glutamate-induced neuronal injury in cortical slices from young (20+/-2 day) and adult (80+/-5 day) rats. Treatment of slices with glutamate receptor agonists NMDA, AMPA and KA elicited the formation of reactive oxygen species (ROS) and neuronal cell death. In young slices, NMDA receptor stimulation caused a higher ROS formation and neurotoxicity, but KA was more effective in producing ROS and cell death in adult slices. AMPA exhibited an intermediate effect on ROS formation and toxicity in both the age groups. A significant protection in glutamate mediated ROS formation and neurotoxicity was observed in presence of NMDA or/and non-NMDA receptors antagonists APV and NBQX, respectively. This further confirms the involvement of both NMDA and non-NMDA receptors in glutamate mediated neurotoxicity. In adult slices, we did not find positive correlation between ligand induced neurotoxicity and mitochondrial depolarization. Though, NMDA and KA stimulation produced differential effect on ROS formation and neurotoxicity in young and adult slices, the mitochondrial depolarization was higher and comparable on NMDA stimulation in both the age groups as compared to KA, suggesting that the mitochondrial depolarization may not be a good indicator for neurotoxicity. Our results demonstrate that both NMDA and non-NMDA sub-types of glutamate receptors are involved in glutamate mediated neurotoxicity but their relative contribution is highly dependent on the age of the animal. JF - Neurochemistry international AU - Sanganahalli, Basavaraju G AU - Joshi, Preeti G AU - Joshi, Nanda B AD - Department of Biophysics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 475 EP - 480 VL - 49 IS - 5 SN - 0197-0186, 0197-0186 KW - Reactive Oxygen Species KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - N-Methylaspartate KW - 6384-92-5 KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Kainic Acid -- pharmacology KW - Spectrometry, Fluorescence KW - N-Methylaspartate -- pharmacology KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - L-Lactate Dehydrogenase -- metabolism KW - Cerebral Cortex -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- agonists KW - Cerebral Cortex -- metabolism KW - Cerebral Cortex -- enzymology KW - Oxidative Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68745707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=NMDA+and+non-NMDA+receptors+stimulation+causes+differential+oxidative+stress+in+rat+cortical+slices.&rft.au=Sanganahalli%2C+Basavaraju+G%3BJoshi%2C+Preeti+G%3BJoshi%2C+Nanda+B&rft.aulast=Sanganahalli&rft.aufirst=Basavaraju&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-18 N1 - Date created - 2006-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. AN - 68302742; 17250449 AB - Lung cancer is one of the leading causes of cancer related death in most developed and many developing countries of the world. Due to lack of validated screening methods and poor prognosis, treatment of lung cancer has not improved significantly over the last two decades. Therefore the risk of the disease needs to be minimized by preventive measures. One approach for lung cancer prevention envisages reversal or restriction of precancerous lesions by chemopreventive intervention. It demands a deeper understanding of the pathogenesis of the disease and identification of the ideal point of intervention. In the present investigation, tea components, epigallocatechin gallate (EGCG) and theaflavins (TF) were assessed for their chemopreventive potential when administered in the post initiation phase of lung carcinogenesis in an experimental mouse model. Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia. The observations strongly indicate that both EGCG and TF can influence the expression of these genes to modulate the process of carcinogenesis, resulting in delayed onset and lowered incidence of pre-invasive lung lesions. JF - Asian Pacific journal of cancer prevention : APJCP AU - Banerjee, Sarmistha AU - Manna, Sugata AU - Mukherjee, Sudeshna AU - Pal, Debalina AU - Panda, Chinmay Kr AU - Das, Sukta AD - Department of Oncogene Regulation, Chittarajan National Cancer Institute, Kolkata 700026, India. PY - 2006 SP - 661 EP - 666 VL - 7 IS - 4 SN - 1513-7368, 1513-7368 KW - Benzopyrenes KW - 0 KW - Biflavonoids KW - Flavonoids KW - Phenols KW - Polyphenols KW - Tea KW - theaflavin KW - 1IA46M0D13 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals, Newborn KW - Animals KW - Blotting, Western KW - Catechin -- analogs & derivatives KW - Disease Progression KW - Biflavonoids -- pharmacology KW - Mice KW - Catechin -- pharmacology KW - Lung Neoplasms -- prevention & control KW - Phenols -- pharmacology KW - Cyclooxygenase 2 -- drug effects KW - Tea -- chemistry KW - Lung Neoplasms -- chemically induced KW - Flavonoids -- pharmacology KW - Caspase 3 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Black+tea+polyphenols+restrict+benzopyrene-induced+mouse+lung+cancer+progression+through+inhibition+of+Cox-2+and+induction+of+caspase-3+expression.&rft.au=Banerjee%2C+Sarmistha%3BManna%2C+Sugata%3BMukherjee%2C+Sudeshna%3BPal%2C+Debalina%3BPanda%2C+Chinmay+Kr%3BDas%2C+Sukta&rft.aulast=Banerjee&rft.aufirst=Sarmistha&rft.date=2006-10-01&rft.volume=7&rft.issue=4&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. AN - 68255774; 17112570 AB - Non-peptidic delta opioid receptor agonists are being evaluated for a wide range of clinical applications; however, the clinical utility of piperazinyl benzamide delta agonists such as SNC80 may be limited by convulsant activity. The purpose of the present study was to evaluate the electroencephalographic and convulsant activity produced by a high dose of 10 mg/kg SNC80 IM in rhesus monkeys. EEG and behavioral activity were examined in four adult male rhesus monkeys after IM administration of SNC80. Monkeys were seated in a standard primate restraint chair, and EEG activity was recorded using an array of 16 needle electrodes implanted subcutaneously in the scalp in a bipolar (scalp-to-scalp) montage in a longitudinal direction, with bilateral frontal, central, temporal, and occipital leads. Behavior was recorded using video monitoring equipment. Initially, all monkeys were tested with 10 mg/kg SNC80, which is a relatively high dose 3-10-fold greater than doses necessary to produce a variety of other behavioral effects. Behavioral convulsions and EEG seizures were observed in one of the four monkeys. In this monkey, neither behavioral convulsions nor EEG seizures were observed when a lower dose of 3.2 mg/kg was administered nine weeks later or when the same dose of 10 mg/kg SNC80 was administered one year later. These results suggest that IM administration of SNC80 is less potent in producing convulsant effects than in producing other, potentially useful behavioral effects (e.g. antinociception) in rhesus monkeys. JF - Pharmacology, biochemistry, and behavior AU - Danielsson, Ingela AU - Gasior, Maciej AU - Stevenson, Glenn W AU - Folk, John E AU - Rice, Kenner C AU - Negus, S Stevens AD - Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, NIH, United States; Cyberonics, Houston, TX, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 428 EP - 434 VL - 85 IS - 2 SN - 0091-3057, 0091-3057 KW - Benzamides KW - 0 KW - Piperazines KW - Receptors, Opioid, delta KW - 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide KW - 156727-74-1 KW - Index Medicus KW - Animals KW - Macaca mulatta KW - Male KW - Seizures -- chemically induced KW - Benzamides -- pharmacology KW - Receptors, Opioid, delta -- agonists KW - Electroencephalography -- drug effects KW - Piperazines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68255774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Electroencephalographic+and+convulsant+effects+of+the+delta+opioid+agonist+SNC80+in+rhesus+monkeys.&rft.au=Danielsson%2C+Ingela%3BGasior%2C+Maciej%3BStevenson%2C+Glenn+W%3BFolk%2C+John+E%3BRice%2C+Kenner+C%3BNegus%2C+S+Stevens&rft.aulast=Danielsson&rft.aufirst=Ingela&rft.date=2006-10-01&rft.volume=85&rft.issue=2&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1994 Jul 8;37(14):2125-8 [8035418] J Pharmacol Exp Ther. 1993 Nov;267(2):875-82 [8246162] J Pharmacol Exp Ther. 1995 Apr;273(1):359-66 [7714789] Cell Mol Neurobiol. 1995 Dec;15(6):615-35 [8719033] Neurochem Res. 1996 Nov;21(11):1333-45 [8947923] J Pharmacol Exp Ther. 1998 Jul;286(1):362-75 [9655881] Neuroscience. 1999;88(4):1093-135 [10336124] J Pharmacol Exp Ther. 1999 Sep;290(3):1157-64 [10454490] Brain Res. 2005 Feb 1;1033(1):1-12 [15680333] J Pharmacol Exp Ther. 2006 Jun;317(3):1337-48 [16537798] J Pharmacol Exp Ther. 2006 Nov;319(2):507-14 [16751251] J Pharmacol Exp Ther. 1993 Nov;267(2):888-95 [8246164] J Pharmacol Exp Ther. 1994 Sep;270(3):1025-34 [7932149] J Pharmacol Exp Ther. 1993 Nov;267(2):852-7 [8246159] Trends Neurosci. 1988 Jul;11(7):308-14 [2465635] J Neurosci. 1987 Aug;7(8):2445-64 [3039080] Nature. 1977 Jun 9;267(5611):495-9 [195217] J Pharmacol Exp Ther. 1976 Jun;197(3):517-32 [945347] J Pharmacol Exp Ther. 2004 Apr;309(1):173-81 [14722329] Epileptic Disord. 2003 Sep;5(3):149-56 [14684350] J Comp Neurol. 2003 Oct 20;465(3):349-60 [12966560] J Pharmacol Exp Ther. 2002 Nov;303(2):723-9 [12388657] Psychopharmacology (Berl). 2002 Oct;164(1):42-8 [12373418] J Pharmacol Exp Ther. 2002 Feb;300(2):435-41 [11805202] J Pharmacol Exp Ther. 2001 Nov;299(2):629-37 [11602675] Brain Res. 2001 Mar 2;893(1-2):121-34 [11223000] J Pharmacol Exp Ther. 2001 Mar;296(3):939-46 [11181927] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptors CAR and PXR in the regulation of hepatic metabolism. AN - 68179593; 17118922 AB - The nuclear receptors CAR and PXR were first characterized as xenosensing transcription factors regulating the induction of phase I and II xenobiotic-metabolizing enzymes as well as transporters in response to exogenous stimuli. It has now become clear, however, that these receptors cross-talk with endogenous stimuli as well, which extends their regulation to various physiological processes such as energy metabolism and cell growth. As recognition of the function of these receptors has widened, the molecular mechanism of their regulation has evolved from simple protein-DNA binding to regulation by complex protein-protein interactions. Novel mechanisms as to how xenobiotic exposure alters hepatic metabolic pathways such as gluconeogenesis and beta-oxidation have emerged. At the same time, the molecular mechanism of how endogenous stimuli, such as insulin, regulate xenobiotc metabolism via CAR and PXR have also become evident. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Tien, E S AU - Negishi, M AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. PY - 2006 SP - 1152 EP - 1163 VL - 36 IS - 10-11 SN - 0049-8254, 0049-8254 KW - CLMP protein, human KW - 0 KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Steroid KW - Receptors, Virus KW - pregnane X receptor KW - Index Medicus KW - Animals KW - Inactivation, Metabolic KW - Endocrine System -- physiology KW - Humans KW - Homeostasis KW - Energy Metabolism KW - Cell Growth Processes KW - Signal Transduction KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Steroid -- metabolism KW - Liver -- metabolism KW - Receptors, Virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=Nuclear+receptors+CAR+and+PXR+in+the+regulation+of+hepatic+metabolism.&rft.au=Tien%2C+E+S%3BNegishi%2C+M&rft.aulast=Tien&rft.aufirst=E&rft.date=2006-10-01&rft.volume=36&rft.issue=10-11&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=00498254&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. AN - 68172692; 17118889 AB - The Cancer Imaging Program of the National Cancer Institute convened a workshop to assess the current status of hypoxia imaging, to assess what is known about the biology of hypoxia as it relates to cancer and cancer therapy, and to define clinical scenarios in which in vivo hypoxia imaging could prove valuable. Hypoxia, or low oxygenation, has emerged as an important factor in tumor biology and response to cancer treatment. It has been correlated with angiogenesis, tumor aggressiveness, local recurrence, and metastasis, and it appears to be a prognostic factor for several cancers, including those of the cervix, head and neck, prostate, pancreas, and brain. The relationship between tumor oxygenation and response to radiation therapy has been well established, but hypoxia also affects and is affected by some chemotherapeutic agents. Although hypoxia is an important aspect of tumor physiology and response to treatment, the lack of simple and efficient methods to measure and image oxygenation hampers further understanding and limits their prognostic usefulness. There is no gold standard for measuring hypoxia; Eppendorf measurement of pO(2) has been used, but this method is invasive. Recent studies have focused on molecular markers of hypoxia, such as hypoxia inducible factor 1 (HIF-1) and carbonic anhydrase isozyme IX (CA-IX), and on developing noninvasive imaging techniques. This workshop yielded recommendations on using hypoxia measurement to identify patients who would respond best to radiation therapy, which would improve treatment planning. This represents a narrow focus, as hypoxia measurement might also prove useful in drug development and in increasing our understanding of tumor biology. JF - International journal of radiation biology AU - Tatum, James L AU - Kelloff, Gary J AU - Gillies, Robert J AU - Arbeit, Jeffrey M AU - Brown, J Martin AU - Chao, K S Clifford AU - Chapman, J Donald AU - Eckelman, William C AU - Fyles, Anthony W AU - Giaccia, Amato J AU - Hill, Richard P AU - Koch, Cameron J AU - Krishna, Murali Cherukuri AU - Krohn, Kenneth A AU - Lewis, Jason S AU - Mason, Ralph P AU - Melillo, Giovanni AU - Padhani, Anwar R AU - Powis, Garth AU - Rajendran, Joseph G AU - Reba, Richard AU - Robinson, Simon P AU - Semenza, Gregg L AU - Swartz, Harold M AU - Vaupel, Peter AU - Yang, David AU - Croft, Barbara AU - Hoffman, John AU - Liu, Guoying AU - Stone, Helen AU - Sullivan, Daniel AD - National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852-7440, USA. tatumj@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 699 EP - 757 VL - 82 IS - 10 SN - 0955-3002, 0955-3002 KW - Antigens, Neoplasm KW - 0 KW - Biomarkers, Tumor KW - Hypoxia-Inducible Factor 1 KW - Isoenzymes KW - CA9 protein, human KW - EC 4.2.1.1 KW - Carbonic Anhydrase IX KW - Carbonic Anhydrases KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - United States KW - Hypoxia-Inducible Factor 1 -- metabolism KW - Reproducibility of Results KW - Humans KW - National Institutes of Health (U.S.) KW - Prognosis KW - Biomarkers, Tumor -- analysis KW - Carbonic Anhydrases -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Radiography KW - Isoenzymes -- metabolism KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Neoplasms -- diagnostic imaging KW - Oxygen -- metabolism KW - Hypoxia -- diagnosis KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68172692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+biology&rft.atitle=Hypoxia%3A+importance+in+tumor+biology%2C+noninvasive+measurement+by+imaging%2C+and+value+of+its+measurement+in+the+management+of+cancer+therapy.&rft.au=Tatum%2C+James+L%3BKelloff%2C+Gary+J%3BGillies%2C+Robert+J%3BArbeit%2C+Jeffrey+M%3BBrown%2C+J+Martin%3BChao%2C+K+S+Clifford%3BChapman%2C+J+Donald%3BEckelman%2C+William+C%3BFyles%2C+Anthony+W%3BGiaccia%2C+Amato+J%3BHill%2C+Richard+P%3BKoch%2C+Cameron+J%3BKrishna%2C+Murali+Cherukuri%3BKrohn%2C+Kenneth+A%3BLewis%2C+Jason+S%3BMason%2C+Ralph+P%3BMelillo%2C+Giovanni%3BPadhani%2C+Anwar+R%3BPowis%2C+Garth%3BRajendran%2C+Joseph+G%3BReba%2C+Richard%3BRobinson%2C+Simon+P%3BSemenza%2C+Gregg+L%3BSwartz%2C+Harold+M%3BVaupel%2C+Peter%3BYang%2C+David%3BCroft%2C+Barbara%3BHoffman%2C+John%3BLiu%2C+Guoying%3BStone%2C+Helen%3BSullivan%2C+Daniel&rft.aulast=Tatum&rft.aufirst=James&rft.date=2006-10-01&rft.volume=82&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+biology&rft.issn=09553002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reporting of non-communicable disease research in low- and middle-income countries: a pilot bibliometric analysis. AN - 57690392; 477773 AB - Objective: The paper identifies the relative amount of research devoted to non-communicable disease in low- and middle-income countries (LMICs). Design: A bibliometric analysis of a subset of journals published in LMICs was performed. Measurements: Seventy-six peer-reviewed journals focused on general medicine or public health published in 46 LMICs and indexed from 1998 to 2003 in MEDLINE. A total of 24 journals were selected, 4 journals from each of 6 LMIC regions. Searches were refined using 18 non-communicable disease topics with 7,012 articles identified for analysis. Results: More than 40 per cent of articles in LMIC regions focused on non-communicable disease research. The percentage was highest in Eastern Europe/Central Asia (47 per cent) and lowest in Latin America (36 per cent). The percentage of articles published in Sub-Saharan Africa (38 per cent) did not differ significantly from that of Latin America or South Asia. Cardiovascular disease and cancer led the list of the top ten most-indexed published topics by region. Conclusions: Even in regions rampant with infectious diseases, some capability exists to conduct research on non-communicable diseases. Greater attention should be paid to the conduct and support of such research in LMICs, which will benefit these countries and may yield clues to lower-cost solutions to the burden of these diseases worldwide. (Author abstract) JF - Journal of the Medical Library Association ( JMLA ) AU - Hofman, Karen AU - Ryce, Andrea AU - Prudhomme, Wendy AU - Kotzin, Sheldon AD - National Institutes of Health, Bethesda, MD, USA hofmank@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 PB - Medical Library Association VL - 94 IS - 4 SN - 1536-5050, 1536-5050 KW - Bibliometrics KW - Health care KW - Periodicals KW - Medicine KW - Articles KW - Non communicable diseases KW - 5.24: BIBLIOMETRICS, SCIENTOMETRICS, INFORMETRICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57690392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=Reporting+of+non-communicable+disease+research+in+low-+and+middle-income+countries%3A+a+pilot+bibliometric+analysis.&rft.au=Hofman%2C+Karen%3BRyce%2C+Andrea%3BPrudhomme%2C+Wendy%3BKotzin%2C+Sheldon&rft.aulast=Hofman&rft.aufirst=Karen&rft.date=2006-10-01&rft.volume=94&rft.issue=4&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bibliometrics; Health care; Medicine; Non communicable diseases; Periodicals; Articles ER - TY - JOUR T1 - A blended training approach using videoconferencing for distance education. AN - 57674639; 477785 AB - In 2004, the National Library of Medicine (NLM) recognized the need to expand its outreach activities to minority students. To meet this objective, NLM sponsored a programme presenting information on varied health sciences topics to minority students interested in health sciences careers. An existing initiative, NLM's Adopt-A-School programme, provided an initial foundation for this project. As part of the Adopt-A-School programme, NLM staff provide training at a nearby school site, and students make field trips to the library. In addition, summer work opportunities are provided for some students. To explore the feasibility of providing a more flexible variant of this programme that would extend the training component to more distant schools, NLM partnered with King Drew Medical Magnet High School in Los Angeles to deliver a distance learning programme via synchronous videoconferencing and collaboration technologies. Describes the approaches used in and the preliminary evaluation of the training. (Quotes from original text) JF - Journal of the Medical Library Association ( JMLA ) AU - Locatis, Craig AU - Gaines, Cynthia AU - Liu, Wei-Li AU - Gill, Michael AU - Carney, John AU - Foster, Jaimela AU - McCall, Valerie AU - Woods, Michelle AD - National Library of Medicine, Bethesda, MD, USA locatis@nlm.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 PB - Medical Library Association VL - 94 IS - 4 SN - 1536-5050, 1536-5050 KW - Distance learning KW - Teleconferencing KW - National libraries KW - Videoconferencing KW - National Library of Medicine KW - Students KW - World Wide Web KW - Computer assisted instruction KW - USA KW - Education KW - Teaching KW - Health care KW - Educational technology KW - Medical libraries KW - Medicine KW - 17.11: EDUCATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57674639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=A+blended+training+approach+using+videoconferencing+for+distance+education.&rft.au=Locatis%2C+Craig%3BGaines%2C+Cynthia%3BLiu%2C+Wei-Li%3BGill%2C+Michael%3BCarney%2C+John%3BFoster%2C+Jaimela%3BMcCall%2C+Valerie%3BWoods%2C+Michelle&rft.aulast=Locatis&rft.aufirst=Craig&rft.date=2006-10-01&rft.volume=94&rft.issue=4&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Education; Health care; Medicine; Teaching; Educational technology; Computer assisted instruction; Students; Distance learning; World Wide Web; Videoconferencing; Teleconferencing; National libraries; Medical libraries; USA; National Library of Medicine ER - TY - JOUR T1 - Alterations in CNS Activity Induced by Botulinum Toxin Treatment in Spasmodic Dysphonia: An H2(15)0 PET Study AN - 57113932; 200707727 AB - Speech-related changes in regional cerebral blood flow (rCBF) were measured using H2(15)O positron-emission tomography in 9 adults with adductor spasmodic dysphonia (ADSD) before & after botulinum toxin (BTX) injection & 10 age- & gender-matched volunteers without neurological disorders. Scans were acquired at rest & during production of continuous narrative speech & whispered speech. Speech was recorded during scan acquisition for offline quantification of voice breaks, pitch breaks, & percentage aperiodicity to assess correlations between treatment-related changes in rCBF & clinical improvement. Results demonstrated that speech-related responses in heteromodal sensory areas were significantly reduced in persons with ADSD, compared with volunteers, before the administration of BTX. Three to 4 weeks after BTX injection, speech-related responses were significantly augmented in these regions & in left hemisphere motor areas commonly associated with oral-laryngeal motor control. This pattern of responses was most strongly correlated with the objective measures of clinical improvement (decreases in the frequency of voice breaks, pitch breaks, & percentage aperiodicity). These data suggest a pathophysiological model for ADSD in which BTX treatment results in more efficient cortical processing of sensory information, making this information available to motor areas that use it to more effectively regulate laryngeal movements. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Ali, S Omar AU - Thomassen, Michael AU - Schulz, Geralyn M AU - Hosey, Lara A AU - Varga, Mary AU - Ludlow, Christy L AU - Braun, Allen R AD - c/o Braun -- Language Section, Voice/Speech/Language Branch, National Instit Deafness & Other Communication Disorders, National Instits Health, Bethesda, MD Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1127 EP - 1146 PB - American Speech-Language-Hearing Association, Rockville MD VL - 49 IS - 5 SN - 1092-4388, 1092-4388 KW - adductor spasmodic dysphonia, botulinum toxin, CNS, rCBF, PET KW - Dysphonia KW - Central nervous system KW - Brain KW - Positron emission tomography KW - Botulinum toxin KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57113932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Alterations+in+CNS+Activity+Induced+by+Botulinum+Toxin+Treatment+in+Spasmodic+Dysphonia%3A+An+H2%2815%290+PET+Study&rft.au=Ali%2C+S+Omar%3BThomassen%2C+Michael%3BSchulz%2C+Geralyn+M%3BHosey%2C+Lara+A%3BVarga%2C+Mary%3BLudlow%2C+Christy+L%3BBraun%2C+Allen+R&rft.aulast=Ali&rft.aufirst=S&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282006%2F081%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dysphonia; Botulinum toxin; Central nervous system; Positron emission tomography; Brain DO - http://dx.doi.org/10.1044/1092-4388(2006/081) ER - TY - JOUR T1 - Persistent Psychological Distress in Long-Term Survivors of Pediatric Sarcoma: The Experience at a Single Institution AN - 57092714; 200701418 AB - Background: The long-term psychological impact of pediatric sarcoma is largely unknown. As part of a cross-sectional study examining the late effects of pediatric sarcoma therapy, we examined whether psychological distress or posttraumatic stress symptoms are present in an adult cohort of pediatric sarcoma survivors. Method: Thirty-four patients participated in the study, an average of 17 years after their treatment ended, each completing the SCID module for Posttraumatic Stress Disorder, Impact of Events Scale, Brief Symptom Inventory (BSI) & a questionnaire assessing sociodemographic variables & psychosocial issues. Results: Significant persistent psychological distress characterized this cohort of patients. Seventy-seven percent scored in the clinical range on the BSI. Twelve percent met diagnostic criteria for PTSD. Current psychological distress was associated with intrusive thoughts & avoidant behaviors, male gender, employment, difficulty readjusting to work/school after treatment, & enduring worries about health. No differences were found based on age, presence of metastatic disease or time since diagnosis. Conclusions: This is the first report of a clinical evaluation of psychological distress in a cohort of pediatric sarcoma survivors treated with intensive multimodal cancer therapy. The results suggest that survivors of pediatric sarcoma might be at high risk for adverse psychological outcomes. Appropriate interventions are proposed. Tables, Figures, References. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Wiener, Lori AU - Battles, Haven AU - Bernstein, Donna AU - Long, Lauren AU - Derdak, Joanne AU - Mackall, Crystal L AU - Mansky, Patrick J AD - Pediatic Oncology Branch, National Cancer Instit, Center Cancer Research, National Instits Health wienerl@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 898 EP - 910 PB - John Wiley, Chichester UK VL - 15 IS - 10 SN - 1057-9249, 1057-9249 KW - psychological distress KW - posttraumatic stress KW - pediatric sarcoma KW - long-term survivors KW - intensive treatment KW - cancer KW - oncology KW - Childhood experiences KW - Sarcomas KW - Paediatrics KW - Posttraumatic stress disorder KW - Long term survivors KW - Psychological distress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Persistent+Psychological+Distress+in+Long-Term+Survivors+of+Pediatric+Sarcoma%3A+The+Experience+at+a+Single+Institution&rft.au=Wiener%2C+Lori%3BBattles%2C+Haven%3BBernstein%2C+Donna%3BLong%2C+Lauren%3BDerdak%2C+Joanne%3BMackall%2C+Crystal+L%3BMansky%2C+Patrick+J&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2006-10-01&rft.volume=15&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-01-08 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Psychological distress; Long term survivors; Posttraumatic stress disorder; Paediatrics; Sarcomas; Childhood experiences DO - http://dx.doi.org/10.1002/pon.1024 ER - TY - JOUR T1 - Geochemical evidence for the variation of historical seabird population on Dongdao Island of the South China Sea AN - 51496344; 2007-014763 JF - Journal of Paleolimnology AU - Liu, X D AU - Zhao, S P AU - Sun, L G AU - Luo, H H AU - Yin, X B AU - Xie, Z Q AU - Wang, Y H AU - Liu, K X AU - Wu, X H AU - Ding, X F AU - Fu, D P Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 259 EP - 279 PB - Springer, Dordrecht VL - 36 IS - 3 SN - 0921-2728, 0921-2728 KW - lithostratigraphy KW - isotopes KW - paleoclimatology KW - Holocene KW - cores KW - West Pacific KW - paleoecology KW - Cenozoic KW - radioactive isotopes KW - Dongdao Island KW - carbon KW - sediments KW - absolute age KW - Northwest Pacific KW - chemical composition KW - South China Sea KW - Chordata KW - Quaternary KW - statistical analysis KW - correlation coefficient KW - Aves KW - populations KW - North Pacific KW - Pacific Ocean KW - lacustrine environment KW - islands KW - Cattle Pond KW - C-14 KW - Vertebrata KW - upper Holocene KW - sea-surface temperature KW - Tetrapoda KW - lake sediments KW - 24:Quaternary geology KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51496344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=Geochemical+evidence+for+the+variation+of+historical+seabird+population+on+Dongdao+Island+of+the+South+China+Sea&rft.au=Liu%2C+X+D%3BZhao%2C+S+P%3BSun%2C+L+G%3BLuo%2C+H+H%3BYin%2C+X+B%3BXie%2C+Z+Q%3BWang%2C+Y+H%3BLiu%2C+K+X%3BWu%2C+X+H%3BDing%2C+X+F%3BFu%2C+D+P&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-10-01&rft.volume=36&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-006-9006-9 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 93 N1 - Document feature - illus. incl. sect., strat. cols., 4 tables, geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; Aves; C-14; carbon; Cattle Pond; Cenozoic; chemical composition; Chordata; cores; correlation coefficient; Dongdao Island; Holocene; islands; isotopes; lacustrine environment; lake sediments; lithostratigraphy; North Pacific; Northwest Pacific; Pacific Ocean; paleoclimatology; paleoecology; populations; Quaternary; radioactive isotopes; sea-surface temperature; sediments; South China Sea; statistical analysis; Tetrapoda; upper Holocene; Vertebrata; West Pacific DO - http://dx.doi.org/10.1007/s10933-006-9006-9 ER - TY - JOUR T1 - Living environment and schooling of children with HIV-infected parents in southwest China AN - 36576161; 3379959 AB - A cross-sectional household survey was conducted in Longchuan County, China, to study the lives of children with HIV-infected parents. Registered HI-infected drug users and their households were approached and information about the living environment of children <= 15 years of age was collected. Of the 266 households interviewed, there were 213 children <= 15 years old. Forty percent of the children had lost at least one parent. Most of the children resided in a household with low economic status and a high dependency ratio. One-half of the children experienced discordant family relations, family anxiety and shame. Compared to orphans, non-orphans and their families were less likely to receive social support from the community. Orphans and older children were less likely to attend school and more likely to be truant if enrolled in school. Findings in the current study suggest that many children whose parents are infected with HIV or have died from HIV are living in stressful environments with minimal support from the community. Efforts should be taken to provide support and supervision to these children. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Yang, H AU - Wu, Z. AU - Duan, S AU - Li, Z. AU - Li, X. AU - Shen, M AU - Mathur, A AU - Stanton, B AD - Wayne State University ; National Center for AIDS/STD Control and Prevention, China ; Dehong Prefecture Anti-Epidemic Station, China ; Longchuan County Anti-Epidemic Station, China ; National Cancer Institute, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 647 EP - 655 VL - 18 IS - 7 SN - 0954-0121, 0954-0121 KW - Sociology KW - Social support KW - Households KW - Drug users KW - Living conditions KW - HIV KW - Parents KW - Children KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36576161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Living+environment+and+schooling+of+children+with+HIV-infected+parents+in+southwest+China&rft.au=Yang%2C+H%3BWu%2C+Z.%3BDuan%2C+S%3BLi%2C+Z.%3BLi%2C+X.%3BShen%2C+M%3BMathur%2C+A%3BStanton%2C+B&rft.aulast=Yang&rft.aufirst=H&rft.date=2006-10-01&rft.volume=18&rft.issue=7&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120500282896 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6040 5676; 7480 12162 3898; 2212; 9184; 3754 3755; 5703 3617 6220; 11938 11949 13521; 93 116 30 DO - http://dx.doi.org/10.1080/09540120500282896 ER - TY - JOUR T1 - Familiality of Polarity at Illness Onset in Bipolar Affective Disorder AN - 220488925; 17012686 AB - Bipolar affective disorder is clinically heterogeneous, and clinical features that run in families may help define more homogeneous phenotypes. The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder. The authors studied 971 subjects from 507 families ascertained through sibling pairs with bipolar I or schizoaffective bipolar disorder. Self-reported ages at onset of mania and major depression were used to code polarity at onset as manic, major depressive, or both (mania and major depression in the same onset year). Familial clustering was estimated by using mixed-effects regression analysis, and the relationship between polarity at onset and several other clinical features was assessed. As a preliminary test of genetic validity, the authors assessed the impact of polarity at onset on genetic linkage findings previously detected in this sample. Polarity at onset was significantly familial in this sample. This largely reflected relative pairs concordant for mania at onset, which occurred significantly more frequently than would be expected by chance. Mania at onset substantially increased the genetic linkage signal on chromosome 16p (maximum lod score=4.5) but had no effect on linkage to chromosome 6q. Mania at onset occurred at a later age on average than major depression at onset and was less likely to be complicated by panic attacks or alcoholism. Polarity at illness onset is a familial feature of bipolar affective disorder and is associated with important clinical indicators, which may help define more homogeneous subtypes of bipolar affective disorder. JF - The American Journal of Psychiatry AU - Kassem, Layla AU - Lopez, Victor AU - Hedeker, Don AU - Steele, Jo AU - et al Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1754 EP - 9 CY - Washington PB - American Psychiatric Association VL - 163 IS - 10 SN - 0002953X KW - Medical Sciences--Psychiatry And Neurology KW - Psychiatry KW - Bipolar disorder KW - Mental depression KW - Medical treatment KW - Severity of Illness Index KW - Genetic Linkage KW - Regression Analysis KW - Depressive Disorder, Major -- diagnosis KW - Age of Onset KW - Alcoholism -- diagnosis KW - Humans KW - Bipolar Disorder -- genetics KW - Depressive Disorder, Major -- epidemiology KW - Alcoholism -- genetics KW - Psychotic Disorders -- epidemiology KW - Depressive Disorder, Major -- genetics KW - Phenotype KW - Chromosomes, Human, Pair 6 -- genetics KW - Bipolar Disorder -- epidemiology KW - Lod Score KW - Psychotic Disorders -- genetics KW - Adult KW - Psychotic Disorders -- diagnosis KW - Siblings -- psychology KW - Cluster Analysis KW - Male KW - Female KW - Chromosomes, Human, Pair 16 -- genetics KW - Bipolar Disorder -- diagnosis KW - Family Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220488925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Familiality+of+Polarity+at+Illness+Onset+in+Bipolar+Affective+Disorder&rft.au=Kassem%2C+Layla%3BLopez%2C+Victor%3BHedeker%2C+Don%3BSteele%2C+Jo%3Bet+al&rft.aulast=Kassem&rft.aufirst=Layla&rft.date=2006-10-01&rft.volume=163&rft.issue=10&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Psychiatric Association Oct 2006 N1 - Document feature - Graphs; References N1 - Last updated - 2013-02-08 N1 - CODEN - AJPSAO ER - TY - JOUR T1 - Efficient Design and Analysis of Biospecimens with Measurements Subject to Detection Limit AN - 21073782; 11132893 AB - Pooling biospecimens is a well accepted sampling strategy in biomedical research to reduce study cost of measuring biomarkers, and has been shown in the case of normally distributed data to yield more efficient estimation. In this paper we examine the efficiency of pooling, in the context of information matrix related to estimators of unknown parameters, when the biospecimens being pooled yield incomplete observations due to the instruments' limit of detection. Our investigation of three sampling strategies shows that, for a range of values of the detection limit, pooling is the most efficient sampling procedure. For certain other values of the detection limit, pooling can perform poorly. JF - Biometrical Journal AU - Vexler, Albert AU - Liu, Aiyi AU - Schisterman, Enrique F AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH/DHHS, 6100 Executive Blvd., Rockville, MD 20852, U.S.A, vexlera@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 780 EP - 791 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 5 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Sampling KW - biomarkers KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Efficient+Design+and+Analysis+of+Biospecimens+with+Measurements+Subject+to+Detection+Limit&rft.au=Vexler%2C+Albert%3BLiu%2C+Aiyi%3BSchisterman%2C+Enrique+F&rft.aulast=Vexler&rft.aufirst=Albert&rft.date=2006-10-01&rft.volume=48&rft.issue=5&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610266 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sampling; Data processing; biomarkers DO - http://dx.doi.org/10.1002/bimj.200610266 ER - TY - JOUR T1 - Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States) AN - 20726047; 7137219 AB - Objective: Because of conflicting findings about the relationship between ultraviolet (UV) radiation and the risk of non-Hodgkin lymphoma (NHL), we evaluated the risk of several indicators related to UV, including two not previously studied: dietary vitamin D, and ambient UV levels by residential location. Methods: As part of a case-control study conducted in four Surveillance, Epidemiology, and End Results (SEER) registries, we collected UV information from a self-administered questionnaire and computer-assisted personal interview with 551 NHL cases and 462 controls. We estimated the relative risk (RR) and 95% confidence intervals (CI) from unconditional logistic regression models. Results: Eye color, a marker of host susceptibility to UV, showed a decreasing risk gradient for lightest eyes (0.47) compared to darkest. Relative risks were in the range of 0.73-0.78 for participants reporting more hours in the mid-day summer sun. Use of sunlamps or tanning booths was associated with decreased risk (RR = 0.88), as was estimated overall ambient UV (RR = 0.76 per 50 RB-units) overall. Vitamin D intake from diet and supplements was not related to risk. Results were thus consistent for the various indicators, although some estimated risks were not statistically significant. Effects were generally similar for diffuse large B-cell (DLBCL) and follicular lymphomas. Conclusion: These data suggest a slight protective effect of sunlight against NHL, and they agree with geographic patterns of NHL incidence observed in the US. JF - Cancer Causes & Control AU - Hartge, Patricia AU - Lim, Unhee AU - Freedman, DMichal AU - Colt, Joanne S AU - Cerhan, James R AU - Cozen, Wendy AU - Severson, Richard K AU - Davis, Scott AD - National Cancer Institue, 6120 Executive Blvd. EPS/8090, Rockville, MD, 20852, USA, hartgep@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1045 EP - 1052 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 8 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Eye KW - Statistical analysis KW - sun KW - Models KW - vitamins KW - U.V. radiation KW - Ultraviolet radiation KW - Sun KW - Regression analysis KW - Tanning KW - Sunlight KW - Lymphoma KW - Diets KW - Inventories KW - Data processing KW - Lymphocytes B KW - sunlight KW - Cancer KW - Color KW - USA KW - Vitamin D KW - Epidemiology KW - Dietary supplements KW - summer KW - lymphoma KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Ultraviolet+radiation%2C+dietary+vitamin+D%2C+and+risk+of+non-Hodgkin+lymphoma+%28United+States%29&rft.au=Hartge%2C+Patricia%3BLim%2C+Unhee%3BFreedman%2C+DMichal%3BColt%2C+Joanne+S%3BCerhan%2C+James+R%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K%3BDavis%2C+Scott&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2006-10-01&rft.volume=17&rft.issue=8&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-006-0040-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Diets; Inventories; Data processing; Eye; Lymphocytes B; Statistical analysis; Color; Models; Vitamin D; U.V. radiation; Epidemiology; Dietary supplements; Sun; Regression analysis; Sunlight; Tanning; Lymphoma; non-Hodgkin's lymphoma; vitamins; Ultraviolet radiation; summer; sunlight; lymphoma; sun; Cancer; USA DO - http://dx.doi.org/10.1007/s10552-006-0040-8 ER - TY - JOUR T1 - Opposing Risks of Gastric Cardia and Noncardia Gastric Adenocarcinomas Associated With Helicobacter pylori Seropositivity AN - 20724585; 7124610 AB - BACKGROUND: Colonization with Helicobacter pylori is a risk factor for gastric adenocarcinoma, but the magnitude of this association and its relationship to anatomic location of the cancer, duration of follow-up, age at diagnosis, histologic subtype, and H. pylori strain differences are less clear. We conducted a prospective nested case-control study of H. pylori serology to address these questions. METHODS: Case and control subjects were selected from the 29 133 50- to 69-year-old males recruited into the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. At baseline, detailed demographic data and a serum sample were collected. From 1985 to 1999, 243 incident cases of gastric adenocarcinoma were diagnosed in cohort members. Serum samples from 234 case subjects (173 with noncardia gastric cancers and 61 with gastric cardia cancers) and 234 age-matched control subjects were assayed for antibodies against H. pylori whole-cell and CagA antigens. We fit conditional logistic regression models to estimate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association of H. pylori seropositivity, defined as seropositivity to either whole-cell or CagA antigens, with noncardia gastric and gastric cardia cancers. All statistical tests were two-sided. RESULTS: H. pylori seropositivity was strongly associated with the risk of noncardia gastric cancer (adjusted OR = 7.9, 95% CI = 3.0 to 20.9) but was inversely associated with the risk of gastric cardia cancer (adjusted OR = 0.31, 95% CI = 0.11 to 0.89). H. pylori seropositivity rates did not vary statistically significantly by length of follow-up, age at diagnosis, or histologic subtype. A calculation of rates showed that the absolute risks of noncardia gastric and cardia gastric adenocarcinomas in the H. pylori-positive participants of this cohort would be 63 and 12 per 100 000 person-years, respectively, whereas corresponding rates in H. pylori-negative participants would be 8 and 37 per 100 000 person-years, respectively. CONCLUSION: H. pylori is a strong risk factor for noncardia gastric cancer but is inversely associated with the risk of gastric cardia cancer. These findings bolster the hypothesis that decreasing H. pylori prevalence during the past century may have contributed to lower rates of noncardia cancer and higher rates of cardia cancer in Western countries. JF - Journal of the National Cancer Institute AU - Kamangar, Farin AU - Dawsey, Sanford M AU - Blaser, Martin J AU - Perez-Perez, Guillermo I AU - Pietinen, Pirjo AU - Newschaffer, Craig J AU - Abnet, Christian C AU - Albanes, Demetrius AU - Virtamo, Jarmo AU - Taylor, Philip R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (FK, SMD, CCA, DA, PRT) Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1445 EP - 1452 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 20 SN - 0027-8874, 0027-8874 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - demography KW - Helicobacter pylori KW - Age KW - Statistical analysis KW - Serology KW - Cancer KW - colonization KW - Models KW - Demography KW - Colonization KW - Antibodies KW - Risk factors KW - prevention KW - Regression analysis KW - Gastric cancer KW - Adenocarcinoma KW - R2 23060:Medical and environmental health KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Opposing+Risks+of+Gastric+Cardia+and+Noncardia+Gastric+Adenocarcinomas+Associated+With+Helicobacter+pylori+Seropositivity&rft.au=Kamangar%2C+Farin%3BDawsey%2C+Sanford+M%3BBlaser%2C+Martin+J%3BPerez-Perez%2C+Guillermo+I%3BPietinen%2C+Pirjo%3BNewschaffer%2C+Craig+J%3BAbnet%2C+Christian+C%3BAlbanes%2C+Demetrius%3BVirtamo%2C+Jarmo%3BTaylor%2C+Philip+R&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2006-10-01&rft.volume=98&rft.issue=20&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Colonization; Antibodies; Risk factors; Regression analysis; Statistical analysis; Adenocarcinoma; Gastric cancer; Serology; Models; demography; Age; prevention; colonization; Cancer; Helicobacter pylori ER - TY - JOUR T1 - Comparative genomics of the lactic acid bacteria AN - 20723348; 7126328 AB - Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats. JF - Proceedings of the National Academy of Sciences, USA AU - Makarova, K AU - Slesarev, A AU - Wolf, Y AU - Sorokin, A AU - Mirkin,