TY - CPAPER T1 - Developing Research and Researchers to Address Drugs and Criminalization in African Americans T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39353330; 4463901 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Beatty, Lula Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Ethnic groups KW - Drugs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39353330?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Developing+Research+and+Researchers+to+Address+Drugs+and+Criminalization+in+African+Americans&rft.au=Beatty%2C+Lula&rft.aulast=Beatty&rft.aufirst=Lula&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Patient Reported Outcomes in Medical Practice and Research: Update on the NIH PROMIS Initiative T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39351008; 4462589 DE: JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Riley, William AU - Reeve, Bryce Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39351008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Measurement+of+Patient+Reported+Outcomes+in+Medical+Practice+and+Research%3A+Update+on+the+NIH+PROMIS+Initiative&rft.au=Riley%2C+William%3BReeve%2C+Bryce&rft.aulast=Riley&rft.aufirst=William&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - National Cancer Institute's Small Grants Program for Behavioral Research in Cancer Control: Boosts Careers for Junior Investigators and Fulfils NIH goal T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39349110; 4463435 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Chollette, Veronica Y AU - Crowley, Kathleen Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Cancer KW - Careers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39349110?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=National+Cancer+Institute%27s+Small+Grants+Program+for+Behavioral+Research+in+Cancer+Control%3A+Boosts+Careers+for+Junior+Investigators+and+Fulfils+NIH+goal&rft.au=Chollette%2C+Veronica+Y%3BCrowley%2C+Kathleen&rft.aulast=Chollette&rft.aufirst=Veronica&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - African Americans and the Triad of Drugs, HIV and Criminalization: Research, Training and Service Needs T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39292642; 4463902 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Vereen, Donald Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Africa KW - Human immunodeficiency virus KW - Training KW - Drugs KW - Ethnic groups KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39292642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=African+Americans+and+the+Triad+of+Drugs%2C+HIV+and+Criminalization%3A+Research%2C+Training+and+Service+Needs&rft.au=Vereen%2C+Donald&rft.aulast=Vereen&rft.aufirst=Donald&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - LactMed: A New Database on Drugs and Lactation from the National Library of Medicine T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39290109; 4462935 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Wexler, Philip AU - Anderson, Philip O AU - Knoben, James E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Drugs KW - Lactation KW - Databases KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39290109?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=LactMed%3A+A+New+Database+on+Drugs+and+Lactation+from+the+National+Library+of+Medicine&rft.au=Wexler%2C+Philip%3BAnderson%2C+Philip+O%3BKnoben%2C+James+E&rft.aulast=Wexler&rft.aufirst=Philip&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Healthy Vision Community Awards Program T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39287628; 4463533 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Janiszewski, Rosemary AU - Ammary, Neyal J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Vision KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Healthy+Vision+Community+Awards+Program&rft.au=Janiszewski%2C+Rosemary%3BAmmary%2C+Neyal+J&rft.aulast=Janiszewski&rft.aufirst=Rosemary&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Building a Model for Research Dissemination: Gaining Adoption for Body & Soul T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39267161; 4461073 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Johnson, Lenora E AU - Solomon, Felicia M AU - Baum, Herb AU - Williams, Alexis AU - McCoy, Lisa AU - Bartholomew, Jill AU - Duncan, Taira AU - Robinson, JaMuir Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Models KW - Adoption KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39267161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Building+a+Model+for+Research+Dissemination%3A+Gaining+Adoption+for+Body+%26amp%3B+Soul&rft.au=Johnson%2C+Lenora+E%3BSolomon%2C+Felicia+M%3BBaum%2C+Herb%3BWilliams%2C+Alexis%3BMcCoy%2C+Lisa%3BBartholomew%2C+Jill%3BDuncan%2C+Taira%3BRobinson%2C+JaMuir&rft.aulast=Johnson&rft.aufirst=Lenora&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Public Talks & Science Listens: A Community-Based Participatory Approach to Characterizing Environmental Health Risk & Assessing Needs in the Wake of Hurricanes Katrina & Rita T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39266368; 4460862 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Sullivan, John AU - Bryan, L Parras AU - Gorenstein, Jennifer AU - Fuchs-Young, Robin AU - Diamond, Pam Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Hurricanes KW - Environmental health KW - Public health KW - Environmental assessment KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39266368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=&rft.atitle=How+Color+Coding+Formulaic+Writing+Enhances+Organization%3A+A+Qualitative+Approach+for+Measuring+Student+Affect&rft.au=Geigle%2C+Bryce+A.&rft.aulast=Geigle&rft.aufirst=Bryce&rft.date=2014-06-01&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relationship between Self-Medication with Alcohol and Co-Morbid Alcohol use Disorders among Individuals with Mood and Anxiety Disorders T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39264948; 4460090 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Lakins, Nekisha E AU - Yi, Hsiao-ye AU - Yahr, Harold T AU - Falk, Daniel E Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Alcohols KW - Anxiety KW - Mood KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264948?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Relationship+between+Self-Medication+with+Alcohol+and+Co-Morbid+Alcohol+use+Disorders+among+Individuals+with+Mood+and+Anxiety+Disorders&rft.au=Lakins%2C+Nekisha+E%3BYi%2C+Hsiao-ye%3BYahr%2C+Harold+T%3BFalk%2C+Daniel+E&rft.aulast=Lakins&rft.aufirst=Nekisha&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Analysis of the Willingness of Cardiac Patients for Referral Treatment from a Military Medical Center to Affiliated Community Clinics in Taiwan T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39263812; 4462560 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Ying, Lai Chao Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Taiwan KW - Military KW - Heart KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263812?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=An+Analysis+of+the+Willingness+of+Cardiac+Patients+for+Referral+Treatment+from+a+Military+Medical+Center+to+Affiliated+Community+Clinics+in+Taiwan&rft.au=Ying%2C+Lai+Chao&rft.aulast=Ying&rft.aufirst=Lai&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Research Priorities: Tobacco Control Policies to Reduce Tobacco use among Low SES Women and Girls T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39260896; 4460286 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Levy, Anna T AU - McLellan, Deborah L AU - Fagan, Pebbles AU - Jones, Wanda K AU - Kaufman, Nancy J Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Tobacco KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39260896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Research+Priorities%3A+Tobacco+Control+Policies+to+Reduce+Tobacco+use+among+Low+SES+Women+and+Girls&rft.au=Levy%2C+Anna+T%3BMcLellan%2C+Deborah+L%3BFagan%2C+Pebbles%3BJones%2C+Wanda+K%3BKaufman%2C+Nancy+J&rft.aulast=Levy&rft.aufirst=Anna&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of Perceived Racism and Race-Based Residential Segregation on Cancer Behavioral Risk Profiles: A Study of Asian Americans and Pacific Islanders in California T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39258609; 4464316 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Shariff-Marco, Salma N Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, California KW - Pacific KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Role+of+Perceived+Racism+and+Race-Based+Residential+Segregation+on+Cancer+Behavioral+Risk+Profiles%3A+A+Study+of+Asian+Americans+and+Pacific+Islanders+in+California&rft.au=Shariff-Marco%2C+Salma+N&rft.aulast=Shariff-Marco&rft.aufirst=Salma&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Oral Cancer Education Messages: Reactions of At-Risk African American Men in Washington, D.C T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39205660; 4462479 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Boehm, Karina AU - Daum, Mary AU - Doner, Lynne Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - USA, Washington KW - Africa KW - Ethnic groups KW - Education KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39205660?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Oral+Cancer+Education+Messages%3A+Reactions+of+At-Risk+African+American+Men+in+Washington%2C+D.C&rft.au=Boehm%2C+Karina%3BDaum%2C+Mary%3BDoner%2C+Lynne&rft.aulast=Boehm&rft.aufirst=Karina&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Jonathan Mann, HIV/AIDS, and Human Rights T2 - 134th Annual Meeting and Exposition of the American Public Health Association AN - 39204465; 4464193 JF - 134th Annual Meeting and Exposition of the American Public Health Association AU - Fee, Elizabeth AU - Parry, Manon Y1 - 2006/11/04/ PY - 2006 DA - 2006 Nov 04 KW - Human immunodeficiency virus KW - Human rights KW - Acquired immune deficiency syndrome KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39204465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Jonathan+Mann%2C+HIV%2FAIDS%2C+and+Human+Rights&rft.au=Fee%2C+Elizabeth%3BParry%2C+Manon&rft.aulast=Fee&rft.aufirst=Elizabeth&rft.date=2006-11-04&rft.volume=15&rft.issue=11&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ L2 - http://apha.confex.com/apha/134am/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Effects on ligand interaction and membrane translocation of the positively charged arginine residues situated along the C1 domain binding cleft in the atypical protein kinase C isoforms. AN - 69022025; 16950780 AB - The C1 domain zinc finger structure is highly conserved among the protein kinase C (PKC) superfamily members. As the interaction site for the second messenger sn-1,2-diacylglycerol (DAG) and for the phorbol esters, the C1 domain has been an important target for developing selective ligands for different PKC isoforms. However, the C1 domains of the atypical PKC members are DAG/phorbol ester-insensitive. Compared with the DAG/phorbol ester-sensitive C1 domains, the rim of the binding cleft of the atypical PKC C1 domains possesses four additional positively charged arginine residues (at positions 7, 10, 11, and 20). In this study, we showed that mutation to arginines of the four corresponding sites in the C1b domain of PKCdelta abolished its high potency for phorbol 12,13-dibutyrate in vitro, with only marginal remaining activity for phorbol 12-myristate 13-acetate in vivo. We also demonstrated both in vitro and in vivo that the loss of potency to ligands was cumulative with the introduction of the arginine residues along the rim of the binding cavity rather than the consequence of loss of a single, specific residue. Computer modeling reveals that these arginine residues reduce access of ligands to the binding cleft and change the electrostatic profile of the C1 domain surface, whereas the basic structure of the binding cleft is still maintained. Finally, mutation of the four arginine residues of the atypical PKC C1 domains to the corresponding residues in the deltaC1b domain conferred response to phorbol ester. We speculate that the arginine residues of the C1 domain of atypical PKCs may provide an opportunity for the design of ligands selective for the atypical PKCs. JF - The Journal of biological chemistry AU - Pu, Yongmei AU - Peach, Megan L AU - Garfield, Susan H AU - Wincovitch, Stephen AU - Marquez, Victor E AU - Blumberg, Peter M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/11/03/ PY - 2006 DA - 2006 Nov 03 SP - 33773 EP - 33788 VL - 281 IS - 44 SN - 0021-9258, 0021-9258 KW - Ions KW - 0 KW - Isoenzymes KW - Ligands KW - Arginine KW - 94ZLA3W45F KW - PKC-3 protein KW - EC 2.7.11.13 KW - Protein Kinase C KW - Index Medicus KW - Isoenzymes -- chemistry KW - Animals KW - Models, Molecular KW - Humans KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Computational Biology KW - Protein Binding KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Static Electricity KW - Mutagenesis, Site-Directed KW - Sequence Alignment KW - Ions -- chemistry KW - Molecular Sequence Data KW - Protein Structure, Tertiary KW - Protein Transport KW - Cricetinae KW - Protein Kinase C -- metabolism KW - Cell Membrane -- enzymology KW - Arginine -- metabolism KW - Arginine -- genetics KW - Arginine -- chemistry KW - Protein Kinase C -- genetics KW - Protein Kinase C -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69022025?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Effects+on+ligand+interaction+and+membrane+translocation+of+the+positively+charged+arginine+residues+situated+along+the+C1+domain+binding+cleft+in+the+atypical+protein+kinase+C+isoforms.&rft.au=Pu%2C+Yongmei%3BPeach%2C+Megan+L%3BGarfield%2C+Susan+H%3BWincovitch%2C+Stephen%3BMarquez%2C+Victor+E%3BBlumberg%2C+Peter+M&rft.aulast=Pu&rft.aufirst=Yongmei&rft.date=2006-11-03&rft.volume=281&rft.issue=44&rft.spage=33773&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Design and Synthesis of a Novel Photoaffinity Ligand for the Dopamine and Serotonin Transporters Based on 2 beta -Carbomethoxy-3 beta -biphenyltropane AN - 19735417; 7543287 AB - Tropane-based photoaffinity ligands covalently bind to discrete points of attachment on the dopamine transporter (DAT). To further explore structure-activity relations, a ligand in which the photoactivated group was extended from the 3-position of the tropane ring was synthesized from cocaine via a Stille or Suzuki coupling strategy. 3-(4'-Azido-3'-iodo-biphenyl-4-yl)-8-methyl-8- aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester (11; K sub(i) = 15.1 plus or minus 2.2 nM) demonstrated high binding affinity for the DAT. Moreover, this compound showed moderate binding affinity for the serotonin transporter (SERT, K sub(i) = 109 plus or minus 14 nM), suggesting the potential utility of [ super(125)I]11 in both DAT and SERT protein structure studies. JF - Journal of Medicinal Chemistry AU - Newman, AH AU - Cha, J H AU - Cao, J AU - Kopajtic, T AU - Katz, J L AU - Parnas, M L AU - Vaughan, R AU - Lever, J R AD - Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland, USA Y1 - 2006/11/02/ PY - 2006 DA - 2006 Nov 02 SP - 6621 EP - 6625 VL - 49 IS - 22 SN - 0022-2623, 0022-2623 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Protein structure KW - Dopamine transporter KW - tropane KW - Serotonin transporter KW - Cocaine KW - N3 11008:Neurochemistry KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19735417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Gene+expression+patterns+distinguish+colonoscopically+isolated+human+aberrant+crypt+foci+from+normal+colonic+mucosa.&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Protein structure; tropane; Dopamine transporter; Cocaine; Serotonin transporter DO - http://dx.doi.org/10.1021/jm0603973 ER - TY - JOUR T1 - Temporal bone histopathologic abnormalities associated with mitochondrial mutation T7511C. AN - 85402107; pmid-17075421 AB - We previously reported a mitochondrial T7511C mutation in the tRNA gene in a Japanese family with nonsyndromic hearing loss (HL). However, the temporal bone histopathology associated with T7511C has not been reported. The aim of the present study is to report histopathologic findings of a temporal bone from a patient in the Japanese family with this mutation.Single case study.A temporal bone was obtained from the right ear of a male subject with progressive HL from 5 years of age and who died at 60 years of age from cerebral infarction. The bone was embedded, sectioned, and stained with hematoxylin-eosin for light microscopic study. Graphic reconstruction of the cochlea was performed using the method described by Schuknecht to determine loss of the stria vascularis and neurosensory elements including hair cells and spiral ganglion neurons.The most significant histopathologic finding was severe loss of spiral ganglion cells in all turns of the cochlea. Severe loss of neuronal filaments in Rosenthal's canal was also observed. The organ of Corti showed scattered loss of inner and outer hair cells in the basal turn. Partial atrophy of the stria vascularis was observed in all turns of the cochlea.Our results suggest that severe loss of spiral ganglion cells was the main cause of sensorineural HL associated with the T7511C mutation. JF - The Laryngoscope AU - Ishikawa, Kotaro AU - Tamagawa, Yuya AU - Takahashi, Katsumasa AU - Iino, Yukiko AU - Murakami, Yoshihiko AU - Kakizaki, Keiko AU - Kimura, Hiroshi AU - Kusakari, Jun AU - Hara, Akira AU - Ichimura, Keiichi AD - Department of Otolaryngology-Head and Neck Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan. ishikawak@nidcd.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1982 EP - 1986 VL - 116 IS - 11 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - Atrophy KW - Hearing Loss, Sensorineural: genetics KW - *Hearing Loss, Sensorineural: pathology KW - Humans KW - Male KW - Middle Aged KW - Mitochondria: genetics KW - Mutation KW - Organ of Corti: pathology KW - Spiral Ganglion: cytology KW - Spiral Ganglion: pathology KW - Stria Vascularis: pathology KW - *Temporal Bone: pathology KW - Vestibule, Labyrinth: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85402107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Temporal+bone+histopathologic+abnormalities+associated+with+mitochondrial+mutation+T7511C.&rft.au=Ishikawa%2C+Kotaro%3BTamagawa%2C+Yuya%3BTakahashi%2C+Katsumasa%3BIino%2C+Yukiko%3BMurakami%2C+Yoshihiko%3BKakizaki%2C+Keiko%3BKimura%2C+Hiroshi%3BKusakari%2C+Jun%3BHara%2C+Akira%3BIchimura%2C+Keiichi&rft.aulast=Ishikawa&rft.aufirst=Kotaro&rft.date=2006-11-01&rft.volume=116&rft.issue=11&rft.spage=1982&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Characteristic findings of auditory brainstem response and otoacoustic emission in the Bronx waltzer mouse. AN - 85400039; pmid-16730938 AB - Auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs) were evaluated serially from 1 to 22 months in Bronx waltzer homozygotes (bv/bv), heterozygotes (+/bv) and control (+/+) mice, which were differentiated by means of PCR of marker DNA (D5Mit209). The wave IV threshold of the click-evoked ABR was higher than the DPOAE threshold with the DP growth method in each bv/bv, although the two thresholds were almost the same in the +/+ group. The DP value at 2f(1) - f(2) in the bv/bv showed an apparent decrease at 2 to 3 months of age with 80 dB SPL stimulation using f(2) frequency 7996 Hz and frequency ratio f(2)/f(1) = 1.22, compared to control or heterozygote mice. It was characteristic that the 2f(2) - f(1) DP signal-to-noise ratio (SNR) value was more preserved from 80 to 60 dB SPL than the 2f(1) - f(2) DP value at f(2) frequency 7996 Hz in most bv/bv, however, control mice showed almost the same levels of 2f(1) - f(2) and 2f(2) - f(1) SNR value at both f(2) frequencies of 6006 and 7996 Hz. The preservation of a substantial 2f(2) - f(1) DP suggested that it would be generated basal to the primary-tone place on the basilar membrane and there might be a reflection of the unique function of the remaining outer hair cells in the Bronx waltzer mice. These findings suggest that combination of ABR with DPOAE could offer useful information about differentiating the mechanism of hair cell dysfunction of the hereditary hearing impairment in the clinical fields. JF - Brain & development AU - Inagaki, Masumi AU - Kon, Kaori AU - Suzuki, Seiko AU - Kobayashi, Naoko AU - Kaga, Makiko AU - Nanba, Eiji AD - Department of Developmental Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawa Higashi, Kodaira 187-8553, Japan. inagaki@ncnp-k.go.jp Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 617 EP - 624 VL - 28 IS - 10 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Acoustic Stimulation: methods KW - Age Factors KW - Animals KW - Animals, Newborn KW - Auditory Threshold: physiology KW - Disease Models, Animal KW - Dose-Response Relationship, Radiation KW - *Evoked Potentials, Auditory, Brain Stem: physiology KW - Female KW - Hearing Disorders: genetics KW - *Hearing Disorders: physiopathology KW - Male KW - Mice KW - Mice, Mutant Strains KW - *Otoacoustic Emissions, Spontaneous KW - RNA, Messenger: biosynthesis KW - Reaction Time: physiology KW - Reverse Transcriptase Polymerase Chain Reaction: methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85400039?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Characteristic+findings+of+auditory+brainstem+response+and+otoacoustic+emission+in+the+Bronx+waltzer+mouse.&rft.au=Inagaki%2C+Masumi%3BKon%2C+Kaori%3BSuzuki%2C+Seiko%3BKobayashi%2C+Naoko%3BKaga%2C+Makiko%3BNanba%2C+Eiji&rft.aulast=Inagaki&rft.aufirst=Masumi&rft.date=2006-11-01&rft.volume=28&rft.issue=10&rft.spage=617&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. AN - 85397609; pmid-16962269 AB - Jackson circler (jc) is a spontaneous, recessive mouse mutation that results in circling behavior and an impaired acoustic startle response. In this study, we refined the phenotypic and genetic parameters of the original jc mutation and characterized a new mutant allele, jc(2J). In open-field behavior tests, homozygous jc mutants exhibited abnormal circling and ambulatory behavior that was indistinguishable from that of phenotypically similar mutants with defects in the vestibule of the inner ear. The jc/jc and jc(2J)/jc(2J) mice had stable elevated auditory-evoked brainstem response (ABR) thresholds at the 16kHz stimulus of 88+/-9dB sound pressure levels (SPL) and 43+/-11dB SPL, respectively. Peak latencies and peak time intervals were normal in jc mutants. The jc mice showed no measurable distortion-product otoacoustic emissions (DPOAEs) above the system noise floor. In the mutant cochlea, the apical turn failed to form due to the developmental growth arrest of the cochlear duct at the level of the first turn at gestational day 13.5. In a large intrasubspecific intercross, jc localized to a 0.2cM interval at position 25cM on chromosome 10, which is homologous to the human 6q21 region. On CZECHII/Ei and CAST/Ei backgrounds jc/jc mutant hearing thresholds at the 16kHz stimulus were significantly lower than those observed on the C57BL/6J background, with means of 62+/-22dB SPL and 55+/-18dB SPL, respectively. Genome-wide linkage scans of backcross, intercross, and congenic progeny revealed a complex pattern of genetic and stochastic effects. JF - Hearing research AU - Calderon, Alfredo AU - Derr, Adam AU - Stagner, Barden B AU - Johnson, Kenneth R AU - Martin, Glen AU - Noben-Trauth, Konrad AD - Section on Neurogenetics, Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA. Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 44 EP - 58 VL - 221 IS - 1-2 SN - 0378-5955, 0378-5955 KW - Index Medicus KW - National Library of Medicine KW - Animals KW - *Auditory Threshold KW - *Cochlea: abnormalities KW - Crosses, Genetic KW - Evoked Potentials, Auditory, Brain Stem KW - Hyperkinesis: etiology KW - Mice KW - Mice, Inbred C57BL KW - Mice, Mutant Strains KW - Startle Reaction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85397609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hearing+research&rft.atitle=Cochlear+developmental+defect+and+background-dependent+hearing+thresholds+in+the+Jackson+circler+%28jc%29+mutant+mouse.&rft.au=Calderon%2C+Alfredo%3BDerr%2C+Adam%3BStagner%2C+Barden+B%3BJohnson%2C+Kenneth+R%3BMartin%2C+Glen%3BNoben-Trauth%2C+Konrad&rft.aulast=Calderon&rft.aufirst=Alfredo&rft.date=2006-11-01&rft.volume=221&rft.issue=1-2&rft.spage=44&rft.isbn=&rft.btitle=&rft.title=Hearing+research&rft.issn=03785955&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Functional outcome of supracricoid partial laryngectomy with cricohyoidopexy: radiation failure vs previously untreated cases. AN - 85395607; pmid-17116818 AB - To evaluate the postoperative course and functional outcomes achieved in patients treated with supracricoid partial laryngectomy (SPL) with cricohyoidopexy.Retrospective analysis.National Cancer Institute "Regina Elena."Eighty-two consecutive patients who underwent SPL with cricohyoidopexy between September 1, 1988, and June 30, 2005, were evaluated. The patient cohort was divided into 2 groups: one affected by untreated laryngeal cancer and the other with laryngeal recurrence after radiotherapy.The postoperative complications and functional outcomes of both patient groups were evaluated and statistically compared.No statistical differences were found between the functional results of the 2 groups of patients analyzed.Although a slightly delayed recovery of physiological functions of the larynx could be termed a disadvantage of SCL with cricohyoidopexy after radiotherapy, this operation is a reliable and useful procedure for selected patients with recurrent cancer who would otherwise have been operated on and received a total laryngectomy. JF - Archives of otolaryngology--head & neck surgery AU - Pellini, Raul AU - Manciocco, Valentina AU - Spriano, Giuseppe AD - Department of Otorhinolaryngology--Head and Neck Surgery, National Cancer Institute "Regina Elena," Rome, Italy. Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1221 EP - 1225 VL - 132 IS - 11 SN - 0886-4470, 0886-4470 KW - National Library of Medicine KW - Adult KW - Aged KW - *Carcinoma, Squamous Cell: surgery KW - *Cricoid Cartilage: surgery KW - Deglutition: physiology KW - Female KW - Humans KW - Laryngeal Neoplasms: radiotherapy KW - *Laryngeal Neoplasms: surgery KW - *Laryngectomy: methods KW - Male KW - Middle Aged KW - Neoplasm Recurrence, Local KW - Phonation: physiology KW - Postoperative Complications KW - Retrospective Studies KW - Salvage Therapy KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85395607?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+otolaryngology--head+%26+neck+surgery&rft.atitle=Functional+outcome+of+supracricoid+partial+laryngectomy+with+cricohyoidopexy%3A+radiation+failure+vs+previously+untreated+cases.&rft.au=Pellini%2C+Raul%3BManciocco%2C+Valentina%3BSpriano%2C+Giuseppe&rft.aulast=Pellini&rft.aufirst=Raul&rft.date=2006-11-01&rft.volume=132&rft.issue=11&rft.spage=1221&rft.isbn=&rft.btitle=&rft.title=Archives+of+otolaryngology--head+%26+neck+surgery&rft.issn=08864470&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - The importance of gene-environment interactions and exposure assessment in understanding human diseases AN - 807259651; 13653099 JF - Journal of Exposure Science and Environmental Epidemiology AU - Schwartz, David A AD - 1 Director, National Institute of Environmental Health Sciences and National Toxicology Program, PO Box 12233, Research Triangle Park, NC 27709, USA. E-mail: david.schwartz[AT]niehs.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 474 EP - 476 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 16 IS - 6 SN - 1559-0631, 1559-0631 KW - Toxicology Abstracts KW - Genetics KW - Environmental effects KW - Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807259651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.atitle=The+importance+of+gene-environment+interactions+and+exposure+assessment+in+understanding+human+diseases&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=6&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2012-03-29 N1 - SubjectsTermNotLitGenreText - Genetics; Environmental effects; Diseases DO - http://dx.doi.org/10.1038/sj.jes.7500531 ER - TY - JOUR T1 - NTP-CERHR monograph on the potential human reproductive and developmental effects of di (2-ethylhexyl) phthalate (DEHP). AN - 733098059; 19407857 AB - The National Toxicology Program (NTP) Center for the Evaluation of Risks to Human Reproduction (CERHR) conducted an updated evaluation of the potential for DEHP to cause adverse effects on reproduction and development in humans. The first CERHR expert panel evaluation of DEHP was completed in 2000 by the Phthalates Expert Panel. CERHR selected DEHP for an updated evaluation because of: (1) widespread human exposure, (2) public and government interest in adverse health effects, (3) recently available human exposure studies, and (4) the large number of relevant toxicity papers published since the earlier evaluation. DEHP (CAS RN: 117-81-7) is a high production volume chemical used as a plasticizer of polyvinyl chloride in the manufacture of a wide variety of consumer goods, such as building products, car products, clothing, food packaging, children's products (but not in toys intended for mouthing), and in medical devices made of polyvinyl chloride. The public can be exposed to DEHP by ingesting food, drink or dust that has been in contact with DEHP-containing materials, by inhaling contaminated air or dust, or by undergoing a medical procedure that uses polyvinyl chloride medical tubing or storage bags. It is estimated that the general population of the United States is exposed to DEHP levels ranging from 1 to 30 microg/kg bw/day (micrograms per kilogram body weight per day). The results of this DEHP update evaluation are published in an NTP-CERHR monograph that includes: (1) the NTP Brief, (2) the Expert Panel Update on the Reproductive and Developmental Toxicity of DEHP, and (3) public comments on the expert panel report. The NTP reached the following conclusions on the possible effects of exposure to DEHP on human development and reproduction. Note that the possible levels of concern, from lowest to highest, are negligible concern, minimal concern, some concern, concern, and serious concern. There is serious concern that certain intensive medical treatments of male infants may result in DEHP exposure levels that adversely affect development of the male reproductive tract. DEHP exposure from medical procedures in infants was estimated to be as high as 6000 microg/kg bw/day. There is concern for adverse effects on development of the reproductive tract in male offspring of pregnant and breast feeding women undergoing certain medical procedures that may result in exposure to high levels of DEHP. There is concern for effects of DEHP exposure on development of the male reproductive tract for infants less than one year old. Diet, mouthing of DEHP-containing objects, and certain medical treatments may lead to DEHP exposures that are higher than those experienced by the general population. There is some concern for effects of DEHP exposure on development of the reproductive tract of male children older than one year. As in infants, exposures of children to DEHP may be higher than in the general population. There is some concern for adverse effects of DEHP exposure on development of the male reproductive tract in male offspring of pregnant women not medically exposed to DEHP. Although DEHP exposures are assumed to be the same as for the general population, the developing male reproductive tract is sensitive to the adverse effects of DEHP. There is minimal concern for reproductive toxicity in adults exposed to DEHP at 1 - 30 microg/kg bw/day. This level of concern is not altered for adults medically exposed to DEHP. NTP will transmit the NTP-CERHR Monograph on DEHP to federal and state agencies, interested parties, and the public and it will be available in electronic PDF format on the CERHR web site http://cerhr.niehs.nih.gov and in printed text or CD-ROM from the CERHR. JF - NTP CERHR MON AU - Shelby, Michael D AD - NIEHS, Research Triangle Park, NC 27709, USA. shelby@niehs.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - v, vii EP - 7, II-iii-xiii passim IS - 18 SN - 1556-2271, 1556-2271 KW - Diethylhexyl Phthalate KW - C42K0PH13C KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Humans KW - Environmental Exposure KW - Male KW - Female KW - Pregnancy KW - Fetus -- drug effects KW - Reproduction -- drug effects KW - Diethylhexyl Phthalate -- toxicity KW - Diethylhexyl Phthalate -- pharmacokinetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/733098059?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NTP+CERHR+MON&rft.atitle=NTP-CERHR+monograph+on+the+potential+human+reproductive+and+developmental+effects+of+di+%282-ethylhexyl%29+phthalate+%28DEHP%29.&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2006-11-01&rft.volume=&rft.issue=18&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=NTP+CERHR+MON&rft.issn=15562271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2011-08-16 N1 - Date created - 2009-05-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Multiperson use of syringes among injection drug users in a needle exchange program: a gene-based molecular epidemiologic analysis. AN - 69028440; 16980914 AB - Syringe-sharing behaviors among injection drug users (IDUs) are typically based on self-reports and subject to socially desirable responding. We used 3 short tandem repeat (STR) genetic biomarkers to detect sharing in 2,512 syringes exchanged by 315 IDUs in the Baltimore needle exchange program (NEP; 738 person-visits). Demographic characteristics as well as direct and indirect needle-sharing behaviors corresponding to the closest AIDS Link to Intravenous Experience (ALIVE) study visits were examined for association with multiperson use (MPU) of syringes. Overall, 56% of the syringes exchanged at the Baltimore NEP had evidence of MPU. Less MPU of syringes (48% vs. 71%; P < 0.0001) was seen with more rapid syringe turnaround (<3 days). IDUs always exchanging their own syringes ("primary" syringes) were less likely to return syringes with evidence of MPU (52%) than those who exchanged syringes for others ("secondary" syringes; 64%; P = 0.0001) and those exchanging primary and secondary syringes (58%; P = 0.004). In a multivariate analysis restricted to primary exchangers, MPU of syringes was associated with sharing cotton (adjusted odds ratio [AOR] = 2.06, 95% confidence interval [CI]: 1.30 to 3.28), lending syringes (AOR = 1.70, 95% CI: 1.24 to 2.34), and injecting less than daily (AOR = 0.64, 95% CI: 0.43 to 0.95). These findings support additional public health interventions such as expanded syringe access to prevent HIV and other blood-borne infections. Testing of STRs represents a promising approach to examining and accessing complex behavioral data, including syringe sharing. JF - Journal of acquired immune deficiency syndromes (1999) AU - Shrestha, Sadeep AU - Smith, Michael W AU - Broman, Karl W AU - Farzadegan, Homayoon AU - Vlahov, David AU - Strathdee, Steffanie A AD - Laboratory of Genomic Diversity, National Cancer Institute, NCI-Frederick, MD 21702, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 335 EP - 343 VL - 43 IS - 3 SN - 1525-4135, 1525-4135 KW - DNA, Viral KW - 0 KW - Index Medicus KW - AIDS/HIV KW - Prospective Studies KW - Risk-Taking KW - Needle-Exchange Programs -- statistics & numerical data KW - Humans KW - Needle-Exchange Programs -- legislation & jurisprudence KW - Cohort Studies KW - Adult KW - Surveys and Questionnaires KW - Algorithms KW - Middle Aged KW - Tandem Repeat Sequences KW - Male KW - Female KW - HIV-1 -- genetics KW - Needle Sharing -- statistics & numerical data KW - HIV Infections -- transmission KW - Syringes -- utilization KW - HIV-1 -- classification KW - DNA, Viral -- analysis KW - HIV Infections -- prevention & control KW - Needle Sharing -- adverse effects KW - Syringes -- adverse effects KW - Substance Abuse, Intravenous -- complications KW - HIV Infections -- epidemiology KW - Syringes -- standards KW - Substance Abuse, Intravenous -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69028440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.atitle=Multiperson+use+of+syringes+among+injection+drug+users+in+a+needle+exchange+program%3A+a+gene-based+molecular+epidemiologic+analysis.&rft.au=Shrestha%2C+Sadeep%3BSmith%2C+Michael+W%3BBroman%2C+Karl+W%3BFarzadegan%2C+Homayoon%3BVlahov%2C+David%3BStrathdee%2C+Steffanie+A&rft.aulast=Shrestha&rft.aufirst=Sadeep&rft.date=2006-11-01&rft.volume=43&rft.issue=3&rft.spage=335&rft.isbn=&rft.btitle=&rft.title=Journal+of+acquired+immune+deficiency+syndromes+%281999%29&rft.issn=15254135&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Circulating inflammatory cytokine expression in men with prostate cancer undergoing androgen deprivation therapy. AN - 69027566; 16775253 AB - Prostate cancer (PCa) is one of the most common cancers in men. Androgen deprivation therapy (ADT) is employed in the treatment of patients with metastatic or recurrent PCa, resulting in castrate levels of testosterone. Recent studies have shown that male hypogonadism is associated with increased levels of proinflammatory and diminished concentrations of anti-inflammatory cytokines, which normalize upon testosterone treatment. Furthermore, an inflammatory state is associated with osteoporosis, sarcopenia and metabolic abnormalities. We examined 3 groups of men: 1) 20 men with PCa undergoing ADT for at least 12 months prior to the onset of the study (ADT group); 2) 18 age-matched men with non-metastatic PCa who had undergone local surgery and/or radiotherapy and had not yet received ADT and were eugonadal (non-ADT group); and 3) 20 age-matched healthy eugonadal men (control group). None of the subjects were suffering from any acute or chronic inflammatory conditions. Mean age was similar in the 3 groups (P = .41). Men in the ADT and non-ADT groups had higher BMI compared to the control group (P = .0005 and P = .01, respectively). Men in the ADT group had significantly lower mean serum total (P < .0001) and free (P < .0001) testosterone and estradiol (P < .0001) levels compared to the other 2 groups. No significant differences in serum levels of pro-inflammatory or anti-inflammatory cytokines were observed between the 3 groups. These data suggest that men with PCa undergoing long-term ADT do not have elevated levels of pro-inflammatory cytokines compared to age and disease matched controls. Prospective studies are needed to evaluate for any acute changes in these inflammatory markers that might occur after the initiation of ADT. JF - Journal of andrology AU - Maggio, Marcello AU - Blackford, Amanda AU - Taub, Dennis AU - Carducci, Michael AU - Ble, Alessandro AU - Metter, E Jeffrey AU - Braga-Basaria, Milena AU - Dobs, Adrian AU - Basaria, Shehzad AD - Longitudinal Studies Section, Clinical Research Branch and the Laboratory of Immunology, National Institutes of Health, National Institute on Aging, Baltimore, MD, USA. PY - 2006 SP - 725 EP - 728 VL - 27 IS - 6 SN - 0196-3635, 0196-3635 KW - Androgen Antagonists KW - 0 KW - Interleukins KW - Index Medicus KW - Cross-Sectional Studies KW - Humans KW - Aged KW - Middle Aged KW - Male KW - Hypogonadism -- chemically induced KW - Interleukins -- blood KW - Androgen Antagonists -- therapeutic use KW - Prostatic Neoplasms -- blood KW - Prostatic Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69027566?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personnel+Journal+%28pre-1986%29&rft.atitle=Smart+%28and+Legal%29+Maternity%2FPaternity%2FParental+Leave+Policies&rft.au=Howells%2C+Dana+D%3BBrophy%2C+Jonathan+L&rft.aulast=Howells&rft.aufirst=Dana+D&rft.date=2016-03-01&rft.volume=53&rft.issue=3&rft.spage=14&rft.isbn=&rft.btitle=&rft.title=Benefits+Magazine&rft.issn=21576157&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The concentration-dependent nature of in vitro amphotericin B-itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions. AN - 69025585; 17055706 AB - The interaction between polyenes and azoles is not well understood. We therefore explored the in vitro combination of amphotericin B with itraconazole against 14 clinical Aspergillus fumigatus isolates (9 itraconazole susceptible and 5 itraconazole resistant) with a colorimetric broth microdilution checkerboard technique using two drug interaction models able to explore complicated patterns of interactions: the response surface analysis of Bliss independence and the isobolographic analysis of Loewe additivity zero interaction theories. Synergy was found at combinations with low concentrations of amphotericin B (0.5 mg/L). Synergy was more frequently observed for the itraconazole-resistant isolates than for the itraconazole-susceptible isolates. JF - International journal of antimicrobial agents AU - Meletiadis, Joseph AU - te Dorsthorst, Debbie T A AU - Verweij, Paul E AD - National Cancer Institute, Pediatric Oncology Branch, Bethesda, MD 20892, USA. meletiaj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 439 EP - 449 VL - 28 IS - 5 SN - 0924-8579, 0924-8579 KW - Itraconazole KW - 304NUG5GF4 KW - Amphotericin B KW - 7XU7A7DROE KW - Index Medicus KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Humans KW - Drug Resistance, Fungal KW - Algorithms KW - Drug Synergism KW - Drug Antagonism KW - Microbial Sensitivity Tests KW - Itraconazole -- pharmacology KW - Aspergillus fumigatus -- drug effects KW - Amphotericin B -- pharmacology KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69025585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=The+concentration-dependent+nature+of+in+vitro+amphotericin+B-itraconazole+interaction+against+Aspergillus+fumigatus%3A+isobolographic+and+response+surface+analysis+of+complex+pharmacodynamic+interactions.&rft.au=Meletiadis%2C+Joseph%3Bte+Dorsthorst%2C+Debbie+T+A%3BVerweij%2C+Paul+E&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=28&rft.issue=5&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-22 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Assessment of dermal exposure to benzene and toluene in shoe manufacturing by activated carbon cloth patches. AN - 69015838; 17075621 AB - The aim of this investigation was to use activated carbon cloth (ACC) patches to study the probability and extent of dermal exposure to benzene and toluene in a shoe factory. Inhalation and dermal exposure loading were measured simultaneously in 70 subjects on multiple days resulting in 113 observations. Dermal exposure loading was assessed by ACC patches attached to likely exposed skin areas (e.g. the palm of the hand and abdomen). A control patch at the chest and an organic vapor monitor (OVM) were used to adjust the hand and abdomen patches for the contribution from the air through passive absorption of benzene and toluene on the ACC patches. Systemic exposure was assessed by quantification of unmetabolized benzene (UBz) and toluene (UTol) in urine. Mean air concentrations for the study population were 1.5 and 7.5 ppm for benzene and toluene, respectively. Iterative regression analyses between the control patch, OVM and the dermal patches showed that only a small proportion of the ACC patches at the hand had likely benzene (n = 4; mean 133 microg cm(-2) h(-1)) or toluene (n = 5; mean 256 microg cm(-2) h(-1)) contamination. Positive patches were exclusively observed among subjects performing the task of gluing. Significant dermal exposure loading to the abdomen was detected only for toluene (n = 2; mean 235 microg cm(-2) h(-1)). No relation was found between having a positive hand or abdomen ACC patch and UBz or UTol levels. In contrast a strong association was found between air levels of benzene (p = 0.0016) and toluene (p < 0.0001) and their respective urinary levels. ACC patches are shown to be a useful technique for quantifying the probability of dermal exposure to organic solvents and to provide estimates of the potential contribution of the dermal pathway to systemic exposure. Using ACC patches we show that dermal exposure to benzene and toluene in a shoe manufacturing factory is probably rare, and when it occurred exposures were relatively low and did not significantly contribute to systemic exposure. JF - Journal of environmental monitoring : JEM AU - Vermeulen, Roel AU - Lan, Qing AU - Li, Guilan AU - Rappaport, Stephen M AU - Kim, Sungkyoon AU - van Wendel de Joode, Berna AU - Shen, Min AU - Bohong, Xu AU - Smith, Martyn T AU - Zhang, Luoping AU - Yin, Songnian AU - Rothman, Nathaniel AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD 20892, USA. R.Vermeulen@iras.uu.nl Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1143 EP - 1148 VL - 8 IS - 11 SN - 1464-0325, 1464-0325 KW - Air Pollutants, Occupational KW - 0 KW - Charcoal KW - 16291-96-6 KW - Toluene KW - 3FPU23BG52 KW - Benzene KW - J64922108F KW - Index Medicus KW - Inhalation KW - Textiles KW - Humans KW - Abdomen KW - Hand KW - Urine -- chemistry KW - Charcoal -- chemistry KW - Occupational Exposure KW - Skin -- chemistry KW - Benzene -- analysis KW - Air Pollutants, Occupational -- analysis KW - Shoes KW - Toluene -- urine KW - Toluene -- analysis KW - Patch Tests -- methods KW - Air Pollutants, Occupational -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69015838?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Assessment+of+dermal+exposure+to+benzene+and+toluene+in+shoe+manufacturing+by+activated+carbon+cloth+patches.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BLi%2C+Guilan%3BRappaport%2C+Stephen+M%3BKim%2C+Sungkyoon%3Bvan+Wendel+de+Joode%2C+Berna%3BShen%2C+Min%3BBohong%2C+Xu%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BYin%2C+Songnian%3BRothman%2C+Nathaniel&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2006-11-01&rft.volume=8&rft.issue=11&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. AN - 69006324; 17000014 AB - Diets rich in vegetables and fruits are associated with reduced risk of several major diseases, including neurodegenerative disorders. Although some beneficial phytochemicals might function solely as antioxidants, it is becoming clear that many of the beneficial chemicals in vegetables and fruits evolved as toxins (to dissuade insects and other predators) that, at subtoxic doses, activate adaptive cellular stress-response pathways in a variety of cells including neurons. Examples of such 'preconditioning' or 'neurohormesis' pathways include those involving cell-survival signaling kinases, the transcription factors NRF2 and CREB, and histone deacetylases of the sirtuin family. In these ways, neurohormetic phytochemicals such as resveratrol, sulforaphanes and curcumin might protect neurons against injury and disease by stimulating the production of antioxidant enzymes, neurotrophic factors, protein chaperones and other proteins that help cells to withstand stress. Thus, as we discuss in this review, highly conserved longevity and survival pathways in neurons are the targets of many phytochemicals. JF - Trends in neurosciences AU - Mattson, Mark P AU - Cheng, Aiwu AD - Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. mattsonm@grc.nia.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 632 EP - 639 VL - 29 IS - 11 SN - 0166-2236, 0166-2236 KW - Antioxidants KW - 0 KW - Neuroprotective Agents KW - Plant Extracts KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Neuroprotective Agents -- administration & dosage KW - Humans KW - Neuroprotective Agents -- toxicity KW - Neurons -- metabolism KW - Neurons -- drug effects KW - Antioxidants -- toxicity KW - Plant Extracts -- toxicity KW - Neuronal Plasticity -- drug effects KW - Heat-Shock Response -- drug effects KW - Models, Biological KW - Plant Extracts -- administration & dosage KW - Antioxidants -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69006324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+neurosciences&rft.atitle=Neurohormetic+phytochemicals%3A+Low-dose+toxins+that+induce+adaptive+neuronal+stress+responses.&rft.au=Mattson%2C+Mark+P%3BCheng%2C+Aiwu&rft.aulast=Mattson&rft.aufirst=Mark&rft.date=2006-11-01&rft.volume=29&rft.issue=11&rft.spage=632&rft.isbn=&rft.btitle=&rft.title=Trends+in+neurosciences&rft.issn=01662236&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Lung cancer among nonsmokers. AN - 68999783; 17068413 JF - Epidemiology (Cambridge, Mass.) AU - Blair, Aaron AU - Freeman, Laura Beane AD - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda 20892, MD, USA. blaira@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 601 EP - 603 VL - 17 IS - 6 SN - 1044-3983, 1044-3983 KW - Index Medicus KW - Risk Factors KW - Humans KW - Male KW - Female KW - Occupational Exposure KW - Lung Neoplasms -- etiology KW - Lung Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68999783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Epidemiology+%28Cambridge%2C+Mass.%29&rft.atitle=Lung+cancer+among+nonsmokers.&rft.au=Blair%2C+Aaron%3BFreeman%2C+Laura+Beane&rft.aulast=Blair&rft.aufirst=Aaron&rft.date=2006-11-01&rft.volume=17&rft.issue=6&rft.spage=601&rft.isbn=&rft.btitle=&rft.title=Epidemiology+%28Cambridge%2C+Mass.%29&rft.issn=10443983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-10-27 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Epidemiology. 2006 Nov;17(6):615-23 [17068414] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. AN - 68993041; 17058263 AB - Increased oxidative/nitrosative stress is a major contributing factor to alcohol-mediated mitochondrial dysfunction. However, which mitochondrial proteins are oxidatively modified under alcohol-induced oxidative/nitrosative stress is poorly understood. The aim of this study was to systematically investigate oxidized and/or S-nitrosylated mitochondrial proteins and to use a biotin-N-maleimide probe to evaluate their inactivation in alcoholic fatty livers of rats. Binge or chronic alcohol exposure significantly elevated nitric oxide, inducible nitric oxide synthase, and ethanol-inducible CYP2E1. The biotin-N-maleimide-labeled oxidized and/or S-nitrosylated mitochondrial proteins from pair-fed controls or alcohol-fed rat livers were subsequently purified with streptavidin-agarose. The overall patterns of oxidized and/or S-nitrosylated proteins resolved by 2-dimensional polyacrylamide gel electrophoresis were very similar in the chronic and binge alcohol treatment groups. Seventy-nine proteins that displayed differential spot intensities from those of control rats were identified by mass spectrometry. These include mitochondrial aldehyde dehydrogenase 2 (ALDH2), ATP synthase, acyl-CoA dehydrogenase, 3-ketoacyl-CoA thiolase, and many proteins involved in chaperone activity, mitochondrial electron transfer, and ion transport. The activity of 3-ketoacyl-CoA thiolase involved in mitochondrial beta-oxidation of fatty acids was significantly inhibited in alcohol-exposed rat livers, consistent with hepatic fat accumulation, as determined by biochemical and histological analyses. Measurement of activity and immunoblot results showed that ALDH2 and ATP synthase were also inhibited through oxidative modification of their cysteine or tyrosine residues in alcoholic fatty livers of rats. In conclusion, our results help to explain the underlying mechanism for mitochondrial dysfunction and increased susceptibility to alcohol-mediated liver damage. JF - Hepatology (Baltimore, Md.) AU - Moon, Kwan-Hoon AU - Hood, Brian L AU - Kim, Bong-Jo AU - Hardwick, James P AU - Conrads, Thomas P AU - Veenstra, Timothy D AU - Song, Byoung J AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1218 EP - 1230 VL - 44 IS - 5 SN - 0270-9139, 0270-9139 KW - Central Nervous System Depressants KW - 0 KW - Isoenzymes KW - Maleimides KW - Mitochondrial Proteins KW - Nitrites KW - maleimide KW - 2519R1UGP8 KW - Ethanol KW - 3K9958V90M KW - Cytochrome P-450 CYP2E1 KW - EC 1.14.13.- KW - Nitric Oxide Synthase KW - EC 1.14.13.39 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Animals KW - Cysteine -- metabolism KW - Nitrites -- metabolism KW - Cytochrome P-450 CYP2E1 -- metabolism KW - Maleimides -- metabolism KW - Isoenzymes -- metabolism KW - Sequence Analysis, Protein KW - Oxidation-Reduction KW - Rats KW - Rats, Sprague-Dawley KW - Oxidative Stress KW - Nitrosation KW - Nitric Oxide Synthase -- metabolism KW - Male KW - Ethanol -- adverse effects KW - Mitochondria, Liver -- enzymology KW - Central Nervous System Depressants -- adverse effects KW - Fatty Liver, Alcoholic -- metabolism KW - Fatty Liver, Alcoholic -- etiology KW - Mitochondrial Proteins -- metabolism KW - Mitochondrial Proteins -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68993041?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Inactivation+of+oxidized+and+S-nitrosylated+mitochondrial+proteins+in+alcoholic+fatty+liver+of+rats.&rft.au=Moon%2C+Kwan-Hoon%3BHood%2C+Brian+L%3BKim%2C+Bong-Jo%3BHardwick%2C+James+P%3BConrads%2C+Thomas+P%3BVeenstra%2C+Timothy+D%3BSong%2C+Byoung+J&rft.aulast=Moon&rft.aufirst=Kwan-Hoon&rft.date=2006-11-01&rft.volume=44&rft.issue=5&rft.spage=1218&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-10-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. AN - 68983323; 16887932 AB - Previous studies on the drug content of pelleted tubulin polymers suggest that peloruside A binds in the laulimalide site, which is distinct from the taxoid site. In a tubulin assembly system containing microtubule-associated proteins and GTP, however, peloruside A was significantly less active than laulimalide, inducing assembly in a manner that was most similar to sarcodictyins A and B. Because peloruside A thus far seems to be the only compound that mimics the action of laulimalide, we examined combinations of microtubule-stabilizing agents for synergistic effects on tubulin assembly. We found that peloruside A and laulimalide showed no synergism but that both compounds could act synergistically with a number of taxoid site agents [paclitaxel, epothilones A/B, discodermolide, dictyostatin, eleutherobin, the steroid derivative 17beta-acetoxy-2-ethoxy-6-oxo-B-homo-estra-1,3,5(10)-trien-3-ol, and cyclostreptin]. None of the taxoid site compounds showed any synergism with each other. From an initial study with peloruside A and cyclostreptin, we conclude that the synergism phenomenon derives, at least in part, from an apparent lowering of the tubulin critical concentration with drug combinations compared with single drugs. The apparent binding of peloruside A in the laulimalide site led us to attempt construction of a pharmacophore model based on superposition of an energy-minimized structure of peloruside A on the crystal structure of laulimalide. Although the different sizes of the macrocycles limited our ability to superimpose the two molecules, atom correspondences that were observed were consistent with the difficulty so far experienced in creation of fully active analogs of laulimalide. JF - Molecular pharmacology AU - Hamel, Ernest AU - Day, Billy W AU - Miller, John H AU - Jung, M Katherine AU - Northcote, Peter T AU - Ghosh, Arun K AU - Curran, Dennis P AU - Cushman, Mark AU - Nicolaou, K C AU - Paterson, Ian AU - Sorensen, Erik J AD - Toxicology and Pharmacology Branch, Developmental Threapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, MD 21702, USA. hamele@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1555 EP - 1564 VL - 70 IS - 5 SN - 0026-895X, 0026-895X KW - Bridged Bicyclo Compounds, Heterocyclic KW - 0 KW - Lactones KW - Macrolides KW - Microtubule-Associated Proteins KW - Taxoids KW - Tubulin KW - laulimalide KW - peloruside A KW - Glutamic Acid KW - 3KX376GY7L KW - Guanosine Triphosphate KW - 86-01-1 KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Microtubule-Associated Proteins -- metabolism KW - Glutamic Acid -- metabolism KW - Tumor Cells, Cultured KW - Models, Molecular KW - Humans KW - Temperature KW - Paclitaxel -- pharmacology KW - Drug Synergism KW - Guanosine Triphosphate -- metabolism KW - Bridged Bicyclo Compounds, Heterocyclic -- chemistry KW - Bridged Bicyclo Compounds, Heterocyclic -- pharmacology KW - Lactones -- chemistry KW - Tubulin -- metabolism KW - Taxoids -- pharmacology KW - Taxoids -- chemistry KW - Lactones -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68983323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Synergistic+effects+of+peloruside+A+and+laulimalide+with+taxoid+site+drugs%2C+but+not+with+each+other%2C+on+tubulin+assembly.&rft.au=Hamel%2C+Ernest%3BDay%2C+Billy+W%3BMiller%2C+John+H%3BJung%2C+M+Katherine%3BNorthcote%2C+Peter+T%3BGhosh%2C+Arun+K%3BCurran%2C+Dennis+P%3BCushman%2C+Mark%3BNicolaou%2C+K+C%3BPaterson%2C+Ian%3BSorensen%2C+Erik+J&rft.aulast=Hamel&rft.aufirst=Ernest&rft.date=2006-11-01&rft.volume=70&rft.issue=5&rft.spage=1555&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward a model of drug relapse: an assessment of the validity of the reinstatement procedure. AN - 68976753; 17019567 AB - The reinstatement model is widely used to study relapse to drug addiction. However, the model's validity is open to question. We assess the reinstatement model in terms of criterion and construct validity. We find that the reinstatement model has adequate criterion validity in the broad sense of the term, as evidenced by the fact that reinstatement in laboratory animals is induced by conditions reported to provoke relapse in humans. The model's criterion validity in the narrower sense, as a medication screen, seems promising for relapse to heroin, nicotine, and alcohol. For relapse to cocaine, criterion validity has not yet been established primarily because clinical studies have examined medication's effects on reductions in cocaine intake rather than relapse during abstinence. The model's construct validity faces more substantial challenges and is yet to be established, but we argue that some of the criticisms of the model in this regard may have been overstated. JF - Psychopharmacology AU - Epstein, David H AU - Preston, Kenzie L AU - Stewart, Jane AU - Shaham, Yavin AD - Clinical Pharmacology and Therapeutics Research Branch, IRP/NIDA/NIH/DHHS, Baltimore, MD 21224, USA. depstein@intra.nida.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1 EP - 16 VL - 189 IS - 1 SN - 0033-3158, 0033-3158 KW - Index Medicus KW - Animals KW - Extinction, Psychological KW - Reproducibility of Results KW - Humans KW - Cocaine-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Recurrence KW - Cocaine-Related Disorders -- prevention & control KW - Stress, Psychological KW - Motor Activity KW - Conditioning, Operant KW - Cues KW - Heroin Dependence -- prevention & control KW - Tobacco Use Disorder -- psychology KW - Tobacco Use Disorder -- prevention & control KW - Heroin Dependence -- psychology KW - Alcoholism -- prevention & control KW - Models, Animal KW - Behavior, Addictive -- prevention & control KW - Behavior, Addictive -- psychology KW - Substance-Related Disorders -- psychology KW - Behavior, Animal KW - Substance-Related Disorders -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68976753?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Toward+a+model+of+drug+relapse%3A+an+assessment+of+the+validity+of+the+reinstatement+procedure.&rft.au=Epstein%2C+David+H%3BPreston%2C+Kenzie+L%3BStewart%2C+Jane%3BShaham%2C+Yavin&rft.aulast=Epstein&rft.aufirst=David&rft.date=2006-11-01&rft.volume=189&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited 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[7675970] J Consult Clin Psychol. 1996 Apr;64(2):366-79 [8871421] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. AN - 68975392; 16891616 AB - Microglial activation is implicated in the progressive nature of numerous neurodegenerative diseases, including Parkinson's disease. Using primary rat mesencephalic neuron-glia cultures, we found that pituitary adenylate cyclase-activating polypeptide (PACAP) 38, PACAP27, and its internal peptide, Gly-Ile-Phe (GIF; PACAP4-6), are neuroprotective at 10(-13) M against lipopolysaccharide (LPS)-induced dopaminergic (DA) neurotoxicity, as determined by [(3)H]DA uptake and the number of tyrosine hydroxylase-immunoreactive neurons. PACAP38 and GIF also protected against 1-methyl-4-phenylpyridinium(+)-induced neurotoxicity but only in cultures containing microglia. PACAP38 and GIF ameliorated the production of microglia-derived reactive oxygen species (ROS), where both LPS- and phorbol 12-myristate 13-acetate-induced superoxide and intracellular ROS were inhibited. The critical role of NADPH oxidase for GIF and PACAP38 neuroprotection against LPS-induced DA neurotoxicity was demonstrated using neuron-glia cultures from mice deficient in NADPH oxidase (PHOX(-/-)), where PACAP38 and GIF reduced tumor necrosis factor alpha production and were neuroprotective only in PHOX(+/+) cultures and not in PHOX(-/-) cultures. Pretreatment with PACAP6-38 (3 microM; PACAP-specific receptor antagonist) was unable to attenuate PACAP38, PACAP27, or GIF (10(-13) M) neuroprotection. PACAP38 and GIF (10(-13) M) failed to induce cAMP in neuronglia cultures, supporting that the neuroprotective effect was independent of traditional high-affinity PACAP receptors. Pharmacophore analysis revealed that GIF shares common chemical properties (hydrogen bond acceptor, positive ionizable, and hydrophobic regions) with other subpicomolar-acting compounds known to inhibit NADPH oxidase: naloxone, dextromethorphan, and Gly-Gly-Phe. These results indicate a common high-affinity site of action across numerous diverse peptides and compounds, revealing a basic neuropeptide regulatory mechanism that inhibits microglia-derived oxidative stress and promotes neuron survival. JF - The Journal of pharmacology and experimental therapeutics AU - Yang, Sufen AU - Yang, Jun AU - Yang, Zhengqin AU - Chen, Posee AU - Fraser, Alison AU - Zhang, Wei AU - Pang, Hao AU - Gao, Xi AU - Wilson, Belinda AU - Hong, Jau-Shyong AU - Block, Michelle L AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, MD F1-01, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 595 EP - 603 VL - 319 IS - 2 SN - 0022-3565, 0022-3565 KW - Lipopolysaccharides KW - 0 KW - Neuroprotective Agents KW - Oligopeptides KW - Pituitary Adenylate Cyclase-Activating Polypeptide KW - Cyclic AMP KW - E0399OZS9N KW - NADPH Oxidase KW - EC 1.6.3.1 KW - Index Medicus KW - Rats KW - Cyclic AMP -- biosynthesis KW - Animals KW - Rats, Inbred F344 KW - Lipopolysaccharides -- toxicity KW - Female KW - Pituitary Adenylate Cyclase-Activating Polypeptide -- pharmacology KW - NADPH Oxidase -- antagonists & inhibitors KW - Oxidative Stress -- drug effects KW - Oligopeptides -- pharmacology KW - NADPH Oxidase -- physiology KW - Microglia -- drug effects KW - Neuroprotective Agents -- pharmacology KW - Microglia -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68975392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Pituitary+adenylate+cyclase-activating+polypeptide+%28PACAP%29+38+and+PACAP4-6+are+neuroprotective+through+inhibition+of+NADPH+oxidase%3A+potent+regulators+of+microglia-mediated+oxidative+stress.&rft.au=Yang%2C+Sufen%3BYang%2C+Jun%3BYang%2C+Zhengqin%3BChen%2C+Posee%3BFraser%2C+Alison%3BZhang%2C+Wei%3BPang%2C+Hao%3BGao%2C+Xi%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Yang&rft.aufirst=Sufen&rft.date=2006-11-01&rft.volume=319&rft.issue=2&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's "phosphate crisis". AN - 68964751; 16759730 AB - Contemporary phytase research is primarily concerned with ameliorating the problem of inadequate digestion of inositol hexakisphosphate (phytate; InsP6) in monogastric farm animal feed, so as to reduce the pollution that results from the high phosphate content of the manure. In the current study we pursue a new, safe and cost-effective solution. We demonstrate that the rate of hydrolysis of InsP6 by recombinant avian MINPP (0.7 micromol/mg protein/min) defines it as by far the most active phytase found to date in any animal cell (the corresponding activity of recombinant mammalian MINPP is only 0.006 micromol/mg protein/min). Although avian MINPP has less than 20% sequence identity with microbial phytases, we create a homology model of MINPP in which it is predicted that the structure of the phytase active site is well-conserved. This model is validated by site-directed mutagenesis and by use of a substrate analogue, scyllo-InsP6, which we demonstrate is only a weak MINPP substrate. In a model chicken cell line, we overexpressed a mutant form of MINPP that is secretion-competent. This version of the enzyme was actively secreted without affecting either cell viability or the cellular levels of any inositol phosphates. Our studies offer a genetic strategy for greatly improving dietary InsP6 digestion in poultry. JF - Journal of biotechnology AU - Cho, Jaiesoon AU - Choi, Kuicheon AU - Darden, Thomas AU - Reynolds, Paul R AU - Petitte, James N AU - Shears, Stephen B AD - Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, NIH, DHSS, Research Triangle Park, PO Box 12233, NC 27709, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 248 EP - 259 VL - 126 IS - 2 SN - 0168-1656, 0168-1656 KW - Phosphates KW - 0 KW - Phytic Acid KW - 7IGF0S7R8I KW - Phosphoric Monoester Hydrolases KW - EC 3.1.3.2 KW - 6-Phytase KW - EC 3.1.3.26 KW - multiple inositol-polyphosphate phosphatase KW - EC 3.1.3.62 KW - Index Medicus KW - Phosphates -- metabolism KW - Animals KW - Cells, Cultured KW - Male KW - Conservation of Natural Resources KW - 6-Phytase -- metabolism KW - Phytic Acid -- metabolism KW - Protein Engineering -- methods KW - Phosphoric Monoester Hydrolases -- genetics KW - 6-Phytase -- genetics KW - Phosphoric Monoester Hydrolases -- metabolism KW - Chickens -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68964751?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biotechnology&rft.atitle=Avian+multiple+inositol+polyphosphate+phosphatase+is+an+active+phytase+that+can+be+engineered+to+help+ameliorate+the+planet%27s+%22phosphate+crisis%22.&rft.au=Cho%2C+Jaiesoon%3BChoi%2C+Kuicheon%3BDarden%2C+Thomas%3BReynolds%2C+Paul+R%3BPetitte%2C+James+N%3BShears%2C+Stephen+B&rft.aulast=Cho&rft.aufirst=Jaiesoon&rft.date=2006-11-01&rft.volume=126&rft.issue=2&rft.spage=248&rft.isbn=&rft.btitle=&rft.title=Journal+of+biotechnology&rft.issn=01681656&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-13 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2000 Sep;20(17):6496-507 [10938126] Biochem Biophys Res Commun. 2000 Aug 28;275(2):279-85 [10964658] Cell Signal. 2001 Mar;13(3):151-8 [11282453] Nat Biotechnol. 2001 May;19(5):415-6 [11329002] Nat Biotechnol. 2001 Aug;19(8):741-5 [11479566] Allergy. 2002 Oct;57(10):943-5 [12269943] Biochem Biophys Res Commun. 2002 Oct 4;297(4):1016-20 [12359257] Poult Sci. 2002 Oct;81(10):1522-32 [12412919] Adv Appl Microbiol. 2000;47:157-99 [12876797] Biochem Biophys Res Commun. 2003 Dec 5;312(1):179-84 [14630039] Biotechnol Lett. 2003 Nov;25(21):1787-94 [14677699] Appl Microbiol Biotechnol. 2004 Jan;63(4):362-72 [14586576] Cancer Res. 1987 Aug 15;47(16):4460-4 [3607775] J Biol Chem. 1991 Sep 5;266(25):16499-506 [1653239] J Biol Chem. 1993 Mar 25;268(9):6161-7 [8384201] J Biol Chem. 1993 Apr 5;268(10):7465-8 [8385108] Adv Appl Microbiol. 1996;42:263-302 [8865587] Nat Struct Biol. 1997 Mar;4(3):185-90 [9164457] Biochem J. 1997 Nov 15;328 ( Pt 1):75-81 [9359836] J Cell Sci. 1998 Mar;111 ( Pt 6):803-13 [9472008] Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13597-602 [9811845] FEBS Lett. 1999 Jan 8;442(1):99-104 [9923613] Appl Environ Microbiol. 1999 Feb;65(2):359-66 [9925554] Appl Environ Microbiol. 1999 Feb;65(2):367-73 [9925555] Genomics. 1999 Mar 15;56(3):324-36 [10087200] Science. 1999 Mar 26;283(5410):2015 [10206902] Poult Sci. 1999 May;78(5):674-82 [10228963] Structure. 2004 Nov;12(11):2015-24 [15530366] Biochem Biophys Res Commun. 2005 Mar 11;328(2):404-8 [15694362] J Inorg Biochem. 2005 Mar;99(3):828-40 [15708805] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10002-5 [15972805] Appl Microbiol Biotechnol. 2005 Sep;68(5):588-97 [16041577] Cell Signal. 2006 Apr;18(4):488-98 [15979280] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. AN - 68952426; 16984405 AB - Lipid rafts are membrane microdomains rich in cholesterol and glycosphingolipids that have been implicated in the regulation of intracellular protein trafficking. During exocytosis, a class of proteins termed SNAREs mediate secretory granule-plasma membrane fusion. To investigate the role of lipid rafts in secretory granule exocytosis, we examined the raft association of SNARE proteins and SNARE complexes in rat basophilic leukemia (RBL) mast cells. The SNARE protein SNAP-23 co-localized with a lipid raft marker and was present in detergent-insoluble lipid raft microdomains in RBL cells. By contrast, only small amounts (<20%) of the plasma membrane SNARE syntaxin 4 or the granule-associated SNARE vesicle-associated membrane protein (VAMP)-2 were present in these microdomains. Despite this, essentially all syntaxin 4 and most of VAMP-2 in these rafts were present in SNARE complexes containing SNAP-23, while essentially none of these complexes were present in nonraft membranes. Whereas SNAP-23 is membrane anchored by palmitoylation, the association of the transmembrane protein syntaxin 4 with lipid rafts was because of its binding to SNAP-23. After stimulating mast cells exocytosis, the amount of syntaxin 4 and VAMP-2 present in rafts increased twofold, and these proteins were now present in raft-associated phospho-SNAP-23/syntaxin 4/VAMP-2 complexes, revealing differential association of SNARE fusion complexes during the process of regulated exocytosis. JF - Traffic (Copenhagen, Denmark) AU - Puri, Niti AU - Roche, Paul A AD - Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1482 EP - 1494 VL - 7 IS - 11 SN - 1398-9219, 1398-9219 KW - Dinitrophenols KW - 0 KW - Qa-SNARE Proteins KW - Receptors, IgE KW - SNARE Proteins KW - Serum Albumin, Bovine KW - Snap23 protein, rat KW - Snap25 protein, mouse KW - Synaptosomal-Associated Protein 25 KW - Vesicle-Associated Membrane Protein 2 KW - Vesicular Transport Proteins KW - dinitrophenyl-bovine serum albumin KW - Immunoglobulin E KW - 37341-29-0 KW - Cholera Toxin KW - 9012-63-9 KW - Index Medicus KW - Animals KW - Vesicular Transport Proteins -- genetics KW - Immunoglobulin E -- pharmacology KW - HeLa Cells KW - Humans KW - Dinitrophenols -- immunology KW - Mice KW - Receptors, IgE -- agonists KW - Protein Binding KW - Vesicle-Associated Membrane Protein 2 -- metabolism KW - Phosphorylation -- drug effects KW - Rats KW - Receptors, IgE -- metabolism KW - Qa-SNARE Proteins -- metabolism KW - Immunoglobulin E -- immunology KW - Transfection KW - Synaptosomal-Associated Protein 25 -- metabolism KW - Serum Albumin, Bovine -- immunology KW - Serum Albumin, Bovine -- pharmacology KW - Dinitrophenols -- pharmacology KW - Gangliosidosis, GM1 -- metabolism KW - Synaptosomal-Associated Protein 25 -- genetics KW - Vesicular Transport Proteins -- metabolism KW - Cholera Toxin -- metabolism KW - Exocytosis -- physiology KW - Exocytosis -- drug effects KW - Membrane Microdomains -- metabolism KW - Mast Cells -- metabolism KW - SNARE Proteins -- genetics KW - Mast Cells -- drug effects KW - SNARE Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68952426?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+%28Copenhagen%2C+Denmark%29&rft.atitle=Ternary+SNARE+complexes+are+enriched+in+lipid+rafts+during+mast+cell+exocytosis.&rft.au=Puri%2C+Niti%3BRoche%2C+Paul+A&rft.aulast=Puri&rft.aufirst=Niti&rft.date=2006-11-01&rft.volume=7&rft.issue=11&rft.spage=1482&rft.isbn=&rft.btitle=&rft.title=Traffic+%28Copenhagen%2C+Denmark%29&rft.issn=13989219&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-10-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cerebellar and other neurological soft signs in antipsychotic-naïve schizophrenia. AN - 68926493; 17022795 AB - Cerebellar neurological abnormalities in schizophrenia have been associated with severe negative symptoms, cognitive deficits, and smaller cerebellar volume. This study assessed the comparative discriminant validity between Cerebellar Soft Signs (CSS) vs. other neurological soft signs (ONSS) [in discriminating between schizophrenia patients and healthy controls] as well as the relationship between the soft signs and psychopathology. Antipsychotic-naïve schizophrenia patients (n = 32) and healthy subjects (n = 32) were examined using International Co-Operative Ataxia Rating Scale and Neurological Evaluation Scale. Mean CSS scores, ONSS total score, and Sensory Integration Signs sub-score were significantly higher in patients. Discriminant analysis revealed two CSS sub-scores (but none of the ONSS scores) to be significant (P < 0.0001) accounting for 78% of classification. CSS total score, Posture sub-score, and Oculomotor sub-score had significant positive correlation with negative syndrome score. Findings support intrinsic cerebellar dysfunction in schizophrenia. The observations are discussed in relationship with cognitive dysmetria. JF - Acta psychiatrica Scandinavica AU - Varambally, S AU - Venkatasubramanian, G AU - Thirthalli, J AU - Janakiramaiah, N AU - Gangadhar, B N AD - Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 352 EP - 356 VL - 114 IS - 5 SN - 0001-690X, 0001-690X KW - Antipsychotic Agents KW - 0 KW - Index Medicus KW - Severity of Illness Index KW - Demography KW - Dysarthria -- epidemiology KW - Alcoholism -- epidemiology KW - Dysarthria -- diagnosis KW - Humans KW - Adult KW - Posture KW - Neuropsychological Tests KW - Male KW - Female KW - Prevalence KW - Ataxia -- physiopathology KW - Ataxia -- diagnosis KW - Cognition Disorders -- diagnosis KW - Cognition Disorders -- epidemiology KW - Schizophrenia -- diagnosis KW - Ataxia -- epidemiology KW - Schizophrenia -- epidemiology KW - Schizophrenia -- physiopathology KW - Cerebellum -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68926493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Acta+psychiatrica+Scandinavica&rft.atitle=Cerebellar+and+other+neurological+soft+signs+in+antipsychotic-na%C3%AFve+schizophrenia.&rft.au=Varambally%2C+S%3BVenkatasubramanian%2C+G%3BThirthalli%2C+J%3BJanakiramaiah%2C+N%3BGangadhar%2C+B+N&rft.aulast=Varambally&rft.aufirst=S&rft.date=2006-11-01&rft.volume=114&rft.issue=5&rft.spage=352&rft.isbn=&rft.btitle=&rft.title=Acta+psychiatrica+Scandinavica&rft.issn=0001690X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-06 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. AN - 68917612; 17016643 AB - Several years after the isolation of deleted in liver cancer 1 (DLC-1), a gene that encodes a Rho GTPase activating protein, the closely related DLC-2 gene was identified. DLC-1 and DLC-2 are approximately 50% identical and share the same SAM-RhoGAP-START domain organization. Since DLC-1 and -2 are located at chromosome regions that are commonly deleted in cancer cells and have been found to function as tumor suppressor genes, we sought to compare their expression profiles in several common types of cancer and to determine whether dlc1 and dlc2 proteins cooperate in tumor development. Using cancer-profiling arrays, we detected for the first time down-regulation of DLC-1 expression in renal, uterine and rectal cancers and down-regulation of DLC-2 expression in lung, ovarian, renal, breast, uterine, gastric, colon and rectal tumors. Since DLC-1 also functions as a metastasis suppressor gene in breast cancer, DLC-1 and DLC-2 expression were examined in a series of primary ductal carcinomas derived from patients with regional lymph node metastases. Using quantitative RT-PCR we detected a significantly lower expression of DLC-1 and DLC-2 in high percentage of tumors, suggesting that deficiency of either DLC gene facilitates dissemination of breast carcinoma cells to secondary sites. We examined DLC-2 expression in DLC-1-negative cell lines derived from human breast, non-small cell lung, and hepatocellular carcinomas, that could be rendered less or non-tumorigenic by ectopic expression of DLC-1. DLC-2 transcripts were detected in all cell lines, indicating that none of the cells were deficient in both members of the DLC family. This comparative expression analysis of DLC-1 and -2 identifies down-regulation of the two emerging bona fide tumor suppressor genes in additional types of solid tumors. The large spectrum of cancers with dysregulated DLC genes underlines the involvement of this family of genes in cancer development. JF - International journal of oncology AU - Ullmannova, Veronika AU - Popescu, Nicholas C AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1127 EP - 1132 VL - 29 IS - 5 SN - 1019-6439, 1019-6439 KW - DLC1 protein, human KW - 0 KW - GTPase-Activating Proteins KW - STARD13 protein, human KW - Tumor Suppressor Proteins KW - Index Medicus KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cell Line, Tumor KW - Gene Expression Profiling KW - Genes, Tumor Suppressor KW - Tumor Suppressor Proteins -- genetics KW - Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68917612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+oncology&rft.atitle=Expression+profile+of+the+tumor+suppressor+genes+DLC-1+and+DLC-2+in+solid+tumors.&rft.au=Ullmannova%2C+Veronika%3BPopescu%2C+Nicholas+C&rft.aulast=Ullmannova&rft.aufirst=Veronika&rft.date=2006-11-01&rft.volume=29&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=International+journal+of+oncology&rft.issn=10196439&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative analysis of in vivo cell proliferation. AN - 68394853; 18428635 AB - Injection and immunohistochemical detection of 5-bromo-2'-deoxyuridine (BrdU) has become the standard method for studying the birth and survival of neurons, glia, and other cell types in the nervous system. BrdU, a thymidine analog, becomes stably incorporated into DNA during the S-phase of mitosis. Because DNA containing BrdU can be specifically recognized by antibodies, this method allows dividing cells to be marked at any given time and then identified at time points from a few minutes to several years later. BrdU immunohistochemistry is suitable for cell counting to examine the regulation of cell proliferation and cell fate. It can be combined with labeling by other antibodies, allowing confocal analysis of cell phenotype or expression of other proteins. The potential for nonspecific labeling and toxicity are discussed. Although BrdU immunohistochemistry has almost completely replaced tritiated thymidine autoradiography for labeling dividing cells, this method and situations in which it is still useful are also described. JF - Current protocols in neuroscience AU - Cameron, Heather A AD - National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 VL - Chapter 3 KW - Antibodies KW - 0 KW - Bromodeoxyuridine KW - G34N38R2N1 KW - Thymidine KW - VC2W18DGKR KW - Index Medicus KW - Thymidine -- metabolism KW - Antibodies -- immunology KW - Animals KW - Cells, Cultured KW - Cell Count -- methods KW - Cell Culture Techniques -- methods KW - Autoradiography -- methods KW - Biological Assay -- methods KW - Nervous System -- cytology KW - Nervous System -- embryology KW - Nervous System -- growth & development KW - Immunohistochemistry -- methods KW - Cell Proliferation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68394853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+protocols+in+neuroscience&rft.atitle=Quantitative+analysis+of+in+vivo+cell+proliferation.&rft.au=Cameron%2C+Heather+A&rft.aulast=Cameron&rft.aufirst=Heather&rft.date=2006-11-01&rft.volume=Chapter+3&rft.issue=&rft.spage=Unit+3.9&rft.isbn=&rft.btitle=&rft.title=Current+protocols+in+neuroscience&rft.issn=1934-8576&rft_id=info:doi/10.1002%2FN0471142301.ns0309s37 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2008-05-29 N1 - Date created - 2008-04-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 DO - http://dx.doi.org/10.1002/N0471142301.ns0309s37 ER - TY - JOUR T1 - Hormonal treatment of human hepatocellular carcinoma. AN - 68305213; 17261772 AB - Animal models of experimental liver carcinogenesis and epidemiological studies in humans suggest a relationship between sex hormones and hepatocellular carcinoma (HCC). In 1997, a systematic review of the existing, small randomized trials evaluating the antiestrogen tamoxifen yielded a positive result, but the large randomized CLIP-1 trial showed no survival advantage from the addition of tamoxifen to best supportive care. A possible explanation for the negative results is the lack of patient selection, but the expression of estrogen (ER) and progesterone (PgR) receptors in HCC does not clearly affect the survival outcome of the patients treated with tamoxifen. In the last years, it has been proposed that negative results might be due to the fact that tamoxifen in HCC could act via an ER-independent pathway, which requires much higher doses than those usually administered, but a double-blind Asian randomized trial conducted to assess possible dose-response effect showed no efficacy for tamoxifen, with an inversely negative impact with increasing dose. According to the results of large trials and of the Cochrane systematic review, neither further trials are warranted with tamoxifen in HCC, nor should any use in clinical practice be considered. Interesting results have been obtained when the type of hormonal treatment (tamoxifen or megestrol) has been chosen according to the presence of wild-type or variant ER, but these results should be confirmed in large randomized trials. Negative results have been obtained with antiandrogen therapy. In conclusion, hormonal treatment should not be a part of the current management of HCC patients. JF - Annals of the New York Academy of Sciences AU - Di Maio, Massimo AU - De Maio, Ermelinda AU - Morabito, Alessandro AU - D'Aniello, Roberta AU - De Feo, Gianfranco AU - Gallo, Ciro AU - Perrone, Francesco AD - Clinical Trials Unit, National Cancer Institute, via Mariano Semmola, 80131 Napoli, Italy. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 252 EP - 261 VL - 1089 SN - 0077-8923, 0077-8923 KW - Androgen Antagonists KW - 0 KW - Antineoplastic Agents, Hormonal KW - Estrogen Antagonists KW - Index Medicus KW - Treatment Failure KW - Randomized Controlled Trials as Topic KW - Humans KW - Treatment Outcome KW - Meta-Analysis as Topic KW - Androgen Antagonists -- adverse effects KW - Carcinoma, Hepatocellular -- drug therapy KW - Androgen Antagonists -- therapeutic use KW - Liver Neoplasms -- drug therapy KW - Estrogen Antagonists -- adverse effects KW - Estrogen Antagonists -- therapeutic use KW - Antineoplastic Agents, Hormonal -- therapeutic use KW - Antineoplastic Agents, Hormonal -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68305213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Hormonal+treatment+of+human+hepatocellular+carcinoma.&rft.au=Di+Maio%2C+Massimo%3BDe+Maio%2C+Ermelinda%3BMorabito%2C+Alessandro%3BD%27Aniello%2C+Roberta%3BDe+Feo%2C+Gianfranco%3BGallo%2C+Ciro%3BPerrone%2C+Francesco&rft.aulast=Di+Maio&rft.aufirst=Massimo&rft.date=2006-11-01&rft.volume=1089&rft.issue=&rft.spage=252&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Implications of recent clinical trials of postmenopausal hormone therapy for management of cardiovascular disease. AN - 68303499; 17261787 AB - Estrogen therapy, originally used for the treatment of menopausal vasomotor symptoms, had by 1990 become a mainstay for the prevention of coronary heart disease (CHD) in postmenopausal women. The recommendations for use of estrogen in CHD were based on epidemiologic, animal, and laboratory data. However, a series of clinical trials published from 1998 onward have failed uniformly to confirm a CHD benefit. When the disappointing results of the secondary prevention trials were announced, there was widespread anticipation of more promising results from the primary prevention trials of the Women's Health Initiative (WHI). The WHI trials in generally healthy women also did not provide evidence of benefit, and the use of HT for disease prevention is now discouraged. In response, some commentators have incorrectly stated that the WHI was not a true primary prevention trial. A more appropriate way to frame the question is whether the effects of HT on cardiovascular disease (CVD) differ by age or years since menopause. Some preliminary data suggest that more recently menopausal women starting HT could be at lower risk of CHD (but not stroke) than women more distant from the menopause. However, even if ongoing studies provide evidence that HT can slow the initiation of early atherosclerosis in younger women, this is unlikely to translate into a reconsideration of the use of HT for the prevention of disease, because the long-term effects on cardiovascular events are unknown and unknowable, HT has other adverse effects, and there are more effective and safer ways of preventing cardiovascular disease. JF - Annals of the New York Academy of Sciences AU - Rossouw, Jacques E AD - Women's Health Initiative, National Heart, Lung, and Blood Institute, Rockledge 2, Room 8106, 6701 Rockledge Drive, Bethesda, MD 20892, USA. rossouwj@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 444 EP - 453 VL - 1089 SN - 0077-8923, 0077-8923 KW - Estrogens KW - 0 KW - Index Medicus KW - Humans KW - Clinical Trials as Topic KW - Female KW - Cardiovascular Diseases -- prevention & control KW - Estrogens -- therapeutic use KW - Coronary Disease -- prevention & control KW - Postmenopause KW - Estrogen Replacement Therapy -- adverse effects KW - Estrogens -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68303499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Implications+of+recent+clinical+trials+of+postmenopausal+hormone+therapy+for+management+of+cardiovascular+disease.&rft.au=Rossouw%2C+Jacques+E&rft.aulast=Rossouw&rft.aufirst=Jacques&rft.date=2006-11-01&rft.volume=1089&rft.issue=&rft.spage=444&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-13 N1 - Date created - 2007-01-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Targeting the epigenome for the treatment of thoracic malignancies. AN - 68298066; 17240824 AB - Despite considerable efforts to improve the diagnosis and treatment of lung cancer, this disease remains the leading cause of cancer-related mortality worldwide. Recent elucidation of epigenetic regulation of gene expression during malignant transformation, together with the identification of agents that modulate DNA methylation and histone acetylation, provide new opportunities for the treatment and prevention of lung cancer via chromatin remodeling mechanisms. Further analysis of molecular response in tumor tissues following exposure to chromatin remodeling agents may enable us to identify novel mechanisms pertaining to lung cancer epigenetics, and design more efficacious regimens. JF - Thoracic surgery clinics AU - Schrump, David S AU - Nguyen, Dao M AD - Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Room 4-3940, 10 Center Drive, MSC 1201, Bethesda, MD 20892-1201, USA. david_schrump@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 367 EP - 77, vi VL - 16 IS - 4 SN - 1547-4127, 1547-4127 KW - Antibiotics, Antineoplastic KW - 0 KW - Antimetabolites, Antineoplastic KW - Chromatin KW - Depsipeptides KW - decitabine KW - 776B62CQ27 KW - romidepsin KW - CX3T89XQBK KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Animals KW - Azacitidine -- pharmacology KW - Azacitidine -- therapeutic use KW - Chromatin -- metabolism KW - Humans KW - Azacitidine -- analogs & derivatives KW - Depsipeptides -- therapeutic use KW - Antibiotics, Antineoplastic -- therapeutic use KW - Antimetabolites, Antineoplastic -- pharmacology KW - Antibiotics, Antineoplastic -- pharmacology KW - Depsipeptides -- pharmacology KW - Drug Evaluation, Preclinical KW - Antimetabolites, Antineoplastic -- therapeutic use KW - Cell Transformation, Neoplastic -- genetics KW - Lung Neoplasms -- drug therapy KW - Lung Neoplasms -- genetics KW - Epigenesis, Genetic KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68298066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Thoracic+surgery+clinics&rft.atitle=Targeting+the+epigenome+for+the+treatment+of+thoracic+malignancies.&rft.au=Schrump%2C+David+S%3BNguyen%2C+Dao+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=4&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Thoracic+surgery+clinics&rft.issn=15474127&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2007-01-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Platelet activation, upregulation of CD11b/ CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smoke. AN - 68285029; 17211980 AB - The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta2 Mac-1 integrin (CD11b/CD18) expression on polymorphonuclear leukocytes (PMN) and monocytes, and P-selectin (CD62P) expression on the platelets of 165 women from eastern India, who cook solely with wood, dung and agricultural wastes, and 155 age- and socio-economic condition-matched control subjects, who used relatively cleaner fuel, liquefied petroleum gas (LPG). Leukocyte-platelet aggregates were defined as CD11b-positive PMN and monocytes co-expressing platelet-specific markers CD41 or CD62P. A significant increase in leukocyte-platelet aggregates was found in women who used biomass as cooking fuel. In addition, they showed increased surface expression of CD11b/CD18 in circulating PMN and monocytes and CD62P expression on platelets. The mean fluorescence intensity (MFI) of CD11b on the surface of circulating monocytes and PMN of biomass users increased by 50 and 68%, respectively. Similarly, a 62 and 48% increase in MFI was observed in CD18 expression on the surface of these cells in biomass users. The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis. JF - Human & experimental toxicology AU - Ray, M R AU - Mukherjee, S AU - Roychoudhury, S AU - Bhattacharya, P AU - Banerjee, M AU - Siddique, S AU - Chakraborty, S AU - Lahiri, T AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute, Kolkata 700 026, India. manasrray@rediffmail.com Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 627 EP - 635 VL - 25 IS - 11 SN - 0960-3271, 0960-3271 KW - Antigens, CD11b KW - 0 KW - Antigens, CD18 KW - Manure KW - P-Selectin KW - Particulate Matter KW - Smoke KW - Index Medicus KW - Antigens, CD11b -- biosynthesis KW - Humans KW - Wood KW - Platelet Activation KW - Particulate Matter -- analysis KW - P-Selectin -- biosynthesis KW - Leukocyte Count KW - India KW - Air Pollution, Indoor -- adverse effects KW - Air Pollution, Indoor -- analysis KW - Adult KW - Plants KW - Particulate Matter -- adverse effects KW - Middle Aged KW - Up-Regulation KW - Female KW - Antigens, CD18 -- biosynthesis KW - Smoke -- adverse effects KW - Blood Platelets -- immunology KW - Neutrophils -- immunology KW - Monocytes -- immunology KW - Cooking KW - Smoke -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68285029?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+experimental+toxicology&rft.atitle=Platelet+activation%2C+upregulation+of+CD11b%2F+CD18+expression+on+leukocytes+and+increase+in+circulating+leukocyte-platelet+aggregates+in+Indian+women+chronically+exposed+to+biomass+smoke.&rft.au=Ray%2C+M+R%3BMukherjee%2C+S%3BRoychoudhury%2C+S%3BBhattacharya%2C+P%3BBanerjee%2C+M%3BSiddique%2C+S%3BChakraborty%2C+S%3BLahiri%2C+T&rft.aulast=Ray&rft.aufirst=M&rft.date=2006-11-01&rft.volume=25&rft.issue=11&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Human+%26+experimental+toxicology&rft.issn=09603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-07 N1 - Date created - 2007-01-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hyperthermic isolation limb perfusion with TNFalpha in the treatment of in-transit melanoma metastasis. AN - 68283351; 17203758 AB - Hyperthermic isolation limb perfusion (HILP) with tumor necrosis factor alpha (TNFalpha) and IFNgamma was pioneered by Liénard and Lejeune in 1988. The TNFalpha was empirically employed at a dosage of 3-4 mg, that is ten times the systemic maximum tolerated dose (MTD). After eighteen years from its first clinical application, more than 300 patients have been treated. The aim of this study is to clarify two major arguments: the TNFalpha dose and eligibility criteria for patient selection. A phase I-II study has previously been conducted in 20 patients with in-transit melanoma metastases using a combination of melphalan and TNFalpha at dosages ranging from 0.5 to 3.3 mg. Twenty patients were treated and a complete pathological response of 70% was recorded, with no correlation between tumor response and TNFalpha. The dose of 1 mg of TNFalpha provided the best results regarding efficacy and toxicity. On the basis of this results a large phase II SITILO study was undertaken. Patients with stage IIIA - IIIAB (presence of in transit metastases and/or regional node involvement) were considered eligible; a total of 113 patients were enrolled in the study. The disease was bulky (> 10 nodules or fewer nodules with a diameter > or = 3 cm) in 42.5% of the patients and unresectable in 33%. Forty patients were treated with a TNFalpha dosage > 1 mg and 73 with 1 mg. All the patients were submitted to HILP via axillary and iliac vessels for tumor of upper and lower limb, respectively. TNFalpha was injected in the extracorporal circuit at the pre-established dose, followed after 30 minutes by melphalan (13 and 10 mg/L of limb volume for upper and lower limbs, respectively). A grade 1 and 2 limb toxicity was found in 52.9% and 30.1% of the patients, respectively, 5.5% of patients exhibited a grade 3 and 4, whereas grade 5 limb toxicity was not found. The complete and partial responses were 63% and 24.5%, respectively, with an objective response of 87.5%. We tried to correlate the typed tumor response (CR or not CR) and the TNFalpha dosage 1 mg, but no statistically significant difference was found between the two groups. The bulky disease was the only prognostic factor able to influence the tumor response. Only patients with bulky melanoma disease can benefit from HILP with TNFalpha at a low dose of 1 mg. JF - In vivo (Athens, Greece) AU - Di Filippo, Franco AU - Rossi, Carlo Riccardo AU - Santinami, Mario AU - Cavaliere, Francesco AU - Garinei, Rosa AU - Anzà, Michele AU - Perri, Pasquale AU - Botti, Claudio AU - Di Angelo, Piera AU - Pasqualoni, Rossella AU - Di Filippo, Simona AD - Regina Elena National Cancer Institute, Rome, Italy. difilippo@ifo.it PY - 2006 SP - 739 EP - 742 VL - 20 IS - 6A SN - 0258-851X, 0258-851X KW - Antineoplastic Agents, Alkylating KW - 0 KW - Tumor Necrosis Factor-alpha KW - Melphalan KW - Q41OR9510P KW - Index Medicus KW - Neoplasm Staging KW - Combined Modality Therapy KW - Chemotherapy, Cancer, Regional Perfusion KW - Humans KW - Aged KW - Antineoplastic Agents, Alkylating -- administration & dosage KW - Drug Therapy, Combination KW - Extremities KW - Aged, 80 and over KW - Melphalan -- administration & dosage KW - Adult KW - Middle Aged KW - Female KW - Male KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Melanoma -- secondary KW - Hyperthermia, Induced KW - Skin Neoplasms -- therapy KW - Skin Neoplasms -- pathology KW - Melanoma -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68283351?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Hyperthermic+isolation+limb+perfusion+with+TNFalpha+in+the+treatment+of+in-transit+melanoma+metastasis.&rft.au=Di+Filippo%2C+Franco%3BRossi%2C+Carlo+Riccardo%3BSantinami%2C+Mario%3BCavaliere%2C+Francesco%3BGarinei%2C+Rosa%3BAnz%C3%A0%2C+Michele%3BPerri%2C+Pasquale%3BBotti%2C+Claudio%3BDi+Angelo%2C+Piera%3BPasqualoni%2C+Rossella%3BDi+Filippo%2C+Simona&rft.aulast=Di+Filippo&rft.aufirst=Franco&rft.date=2006-11-01&rft.volume=20&rft.issue=6A&rft.spage=739&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2007-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Liposomal doxorubicin with and without TNFalpha in the perfusional treatment of advanced soft tissue limb sarcoma: preliminary results. AN - 68277918; 17203757 AB - A combination of doxorubicin and tumor necrosis factor alpha (TNFalpha) has been proven to be very effective in the perfusional treatment of advanced soft tissue limb sarcoma both in terms of tumor necrosis and limb conservative surgery rate. Unfortunately, in some patients a grade IV limb reaction has been recorded. The key solution might be the use of liposomal doxorubicin (Caelyx) because the carrier seems to release the drug preferentially in the tumor rather than in the healthy tissue. Twenty patients were treated with Caelyx: 14 with Caelyx alone and 6 in combination with a low TNFalpha dose (1 mg). In the first series of 14 patients a dose escalation study was carried out starting from a dose of 10 mg/L of limb volume. Six patients were treated with Caelyx (16 mg) and TNFalpha (1 mg). The maximum tolerated dose (MTD) was 16 mg/L as in two patients treated with 18 mg/L a grade IV limb reaction was observed. Tumor response was satisfactory and conservative surgery was carried out in 13 patients. In 6 patients treated with Caelyx and TNFalpha, only a grade I limb reaction was recorded, thus, confirming that TNFalpha did not increase toxicity, at least at a dose of 1 mg. The Caelyx-TNFalpha combination did increase treatment efficacy. Tumor necrosis > or = 70% was observed in 4 out of 6 patients, one with 100% necrosis (pathological complete response). All the patients underwent conservative surgery. The Caelyx-TNFalpha combination was proven to increase the efficacy of Caelyx alone, with a very low toxicity. These preliminary results have to be tested in a larger patient population. JF - In vivo (Athens, Greece) AU - Di Filippo, Franco AU - Anzà, Michele AU - Garinei, Rosa AU - Cavaliere, Francesco AU - Perri, Pasquale AU - Botti, Claudio AU - Di Angelo, Piera AU - Di Filippo, Simona AU - Maini, Carlo Ludovico AU - Pasqualoni, Rossella AU - Di Segni, Susanna AU - Colantonio, Simona AU - Bruno, Pietro AU - Piarulli, Loredana AU - Principi, Francesca AD - Department of Surgery, Regina Elena National Cancer Institute, Rome, Italy. difilippo@ifo.it PY - 2006 SP - 735 EP - 738 VL - 20 IS - 6A SN - 0258-851X, 0258-851X KW - Tumor Necrosis Factor-alpha KW - 0 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Dose-Response Relationship, Drug KW - Combined Modality Therapy KW - Humans KW - Chemotherapy, Cancer, Regional Perfusion KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Male KW - Female KW - Soft Tissue Neoplasms -- pathology KW - Soft Tissue Neoplasms -- drug therapy KW - Sarcoma -- surgery KW - Sarcoma -- drug therapy KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Soft Tissue Neoplasms -- surgery KW - Sarcoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68277918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=In+vivo+%28Athens%2C+Greece%29&rft.atitle=Liposomal+doxorubicin+with+and+without+TNFalpha+in+the+perfusional+treatment+of+advanced+soft+tissue+limb+sarcoma%3A+preliminary+results.&rft.au=Di+Filippo%2C+Franco%3BAnz%C3%A0%2C+Michele%3BGarinei%2C+Rosa%3BCavaliere%2C+Francesco%3BPerri%2C+Pasquale%3BBotti%2C+Claudio%3BDi+Angelo%2C+Piera%3BDi+Filippo%2C+Simona%3BMaini%2C+Carlo+Ludovico%3BPasqualoni%2C+Rossella%3BDi+Segni%2C+Susanna%3BColantonio%2C+Simona%3BBruno%2C+Pietro%3BPiarulli%2C+Loredana%3BPrincipi%2C+Francesca&rft.aulast=Di+Filippo&rft.aufirst=Franco&rft.date=2006-11-01&rft.volume=20&rft.issue=6A&rft.spage=735&rft.isbn=&rft.btitle=&rft.title=In+vivo+%28Athens%2C+Greece%29&rft.issn=0258851X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-26 N1 - Date created - 2007-01-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toxicity and biodistribution of a first-generation recombinant adenoviral vector, encoding aquaporin-1, after retroductal delivery to a single rat submandibular gland. AN - 68258455; 17069536 AB - Before conducting a phase 1/2 clinical trial of a serotype 5 adenovirus encoding human aquaporin-1 (AdhAQP1) for the treatment of radiation-damaged salivary glands, we have conducted a detailed toxicity and biodistribution study in adult rats. AdhAQP1 (2x108-2x1011 particles) was delivered to a single submandibular gland by retroductal cannulation. Administration of this vector resulted in no animal mortality or morbidities, and no adverse signs of clinical toxicity. In addition, over the 92-day time course of the study, with both male and female rats, there were no consistent treatment-related changes in serum indicators of hepatic, renal, and cardiac functions. Importantly, we also observed no vector-associated effects on either water consumption by, or hematocrit levels in, study animals. However, three suggestive mild gender-related response differences were seen. Female, but not male, rats exhibited small reductions in food consumption (10-15%) and body weight gain (5-10%), and evidence of persistent inflammation, after vector treatment. These were vector, but not dose, related. Three days after delivery of 2x1011 particles of AdhAQP1, vector was detected primarily in the targeted gland; 9 of 10 samples from the targeted gland were positive, whereas only 5 of 90 nonoral samples were positive. There was no evidence of the generation of replication-competent adenovirus in saliva or blood samples. In aggregate, these findings show that localized delivery of AdhAQP1 to salivary glands appears to occur without significant toxicity. JF - Human gene therapy AU - Zheng, Changyu AU - Goldsmith, Corinne M AU - Mineshiba, Fumi AU - Chiorini, John A AU - Kerr, Andrew AU - Wenk, Martin L AU - Vallant, Molly AU - Irwin, Richard D AU - Baum, Bruce J AD - Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1122 EP - 1133 VL - 17 IS - 11 SN - 1043-0342, 1043-0342 KW - Antibodies KW - 0 KW - Aqp1 protein, rat KW - Recombinant Proteins KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Rats KW - Animals KW - Antibodies -- blood KW - Recombinant Proteins -- biosynthesis KW - Transgenes KW - Gene Expression KW - Tissue Distribution KW - Recombinant Proteins -- genetics KW - Male KW - Female KW - Drug Administration Routes KW - Genetic Vectors -- administration & dosage KW - Aquaporin 1 -- genetics KW - Aquaporin 1 -- biosynthesis KW - Submandibular Gland -- drug effects KW - Genetic Vectors -- toxicity KW - Genetic Vectors -- genetics KW - Adenoviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68258455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+gene+therapy&rft.atitle=Toxicity+and+biodistribution+of+a+first-generation+recombinant+adenoviral+vector%2C+encoding+aquaporin-1%2C+after+retroductal+delivery+to+a+single+rat+submandibular+gland.&rft.au=Zheng%2C+Changyu%3BGoldsmith%2C+Corinne+M%3BMineshiba%2C+Fumi%3BChiorini%2C+John+A%3BKerr%2C+Andrew%3BWenk%2C+Martin+L%3BVallant%2C+Molly%3BIrwin%2C+Richard+D%3BBaum%2C+Bruce+J&rft.aulast=Zheng&rft.aufirst=Changyu&rft.date=2006-11-01&rft.volume=17&rft.issue=11&rft.spage=1122&rft.isbn=&rft.btitle=&rft.title=Human+gene+therapy&rft.issn=10430342&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-16 N1 - Date created - 2006-12-20 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. AN - 68177937; 17088436 AB - L-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient asparagine for their own needs. Molecular profiling of the NCI-60 cancer cell lines using five different microarray platforms showed strong negative correlations of asparagine synthetase (ASNS) expression and DNA copy number with sensitivity to l-ASP in the leukemia and ovarian cancer cell subsets. To assess whether the ovarian relationship is causal, we used RNA interference to silence ASNS in three ovarian lines and observed 4- to 5-fold potentiation of sensitivity to l-ASP with two of the lines. For OVCAR-8, the line that expresses the least ASNS, the potentiation was >500-fold. Significantly, that potentiation was >700-fold in the multidrug-resistant derivative OVCAR-8/ADR, showing that the causal relationship between ASNS expression and l-ASP activity survives development of classical multidrug resistance. Tissue microarrays confirmed low ASNS expression in a subset of clinical ovarian cancers as well as other tumor types. Overall, this pharmacogenomic/pharmacoproteomic study suggests the use of l-ASP for treatment of a subset of ovarian cancers (and perhaps other tumor types), with ASNS as a biomarker for patient selection. JF - Molecular cancer therapeutics AU - Lorenzi, Philip L AU - Reinhold, William C AU - Rudelius, Martina AU - Gunsior, Michele AU - Shankavaram, Uma AU - Bussey, Kimberly J AU - Scherf, Uwe AU - Eichler, Gabriel S AU - Martin, Scott E AU - Chin, Koei AU - Gray, Joe W AU - Kohn, Elise C AU - Horak, Ivan D AU - Von Hoff, Daniel D AU - Raffeld, Mark AU - Goldsmith, Paul K AU - Caplen, Natasha J AU - Weinstein, John N AD - Genomics and Bioinformatics Group, Room 5056B, 37 Convent Drive, Bethesda, MD 20892, USA. jw4i@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2613 EP - 2623 VL - 5 IS - 11 SN - 1535-7163, 1535-7163 KW - Antineoplastic Agents KW - 0 KW - Biomarkers, Tumor KW - DNA, Neoplasm KW - RNA, Messenger KW - Asparaginase KW - EC 3.5.1.1 KW - Aspartate-Ammonia Ligase KW - EC 6.3.1.1 KW - Index Medicus KW - Gene Expression Profiling KW - RNA, Messenger -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - Cell Line, Tumor KW - RNA Interference KW - Time Factors KW - DNA, Neoplasm -- metabolism KW - Female KW - Drug Resistance, Multiple KW - Biomarkers, Tumor -- metabolism KW - Aspartate-Ammonia Ligase -- metabolism KW - Aspartate-Ammonia Ligase -- genetics KW - Ovarian Neoplasms -- pathology KW - Asparaginase -- toxicity KW - Antineoplastic Agents -- toxicity KW - Ovarian Neoplasms -- enzymology KW - Asparaginase -- pharmacology KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68177937?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+antimicrobial+agents&rft.atitle=The+concentration-dependent+nature+of+in+vitro+amphotericin+B-itraconazole+interaction+against+Aspergillus+fumigatus%3A+isobolographic+and+response+surface+analysis+of+complex+pharmacodynamic+interactions.&rft.au=Meletiadis%2C+Joseph%3Bte+Dorsthorst%2C+Debbie+T+A%3BVerweij%2C+Paul+E&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=28&rft.issue=5&rft.spage=439&rft.isbn=&rft.btitle=&rft.title=International+journal+of+antimicrobial+agents&rft.issn=09248579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-15 N1 - Date created - 2006-11-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression patterns distinguish colonoscopically isolated human aberrant crypt foci from normal colonic mucosa. AN - 68173185; 17119054 AB - Aberrant crypt foci (ACF) are considered the earliest identifiable preneoplastic colonic lesions; thus, a greater understanding of the nature of genetic changes underlying the transformation of normal colonic mucosa (NM) into ACF may provide insight into the mechanisms of carcinogenesis. ACF were identified by indigo carmine spraying onto colonic mucosa during colonoscopy and isolated as standard pinch biopsies of the mucosal areas containing the ACF. RNAs isolated from ACF and matched NM biopsies from the ascending and descending colons of 13 patients were analyzed on arrays containing 9128 cDNAs. Thirty-four differentially expressed (P < 0.001) genes were found in a paired comparison of the ACF and NM samples, and 25 of 26 matched pairs of ACF and NM could be correctly classified in leave-one-out cross-validation. Differential expression for seven of eight genes was confirmed by real-time reverse transcription-PCR. Furthermore, ACF and NM samples, including six pairs of ACF and NM samples that had not previously been analyzed by array hybridization, can be correctly classified on the basis of the overexpression in ACF of three selected genes (REG4, SRPN-B5, and TRIM29) evaluated by real-time reverse transcription-PCR. In a separate analysis of 13 biopsy pairs from either ascending or descending colon, ACF and NM samples could also be correctly classified by the gene expression patterns. Analysis of gene expression differences in ACF from the ascending and descending colon versus NM samples indicates that ACF from these distinct colonic locations are converging toward similar gene expression profiles and losing differences in gene expression characteristic of NM from the ascending versus descending colon. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Glebov, Oleg K AU - Rodriguez, Luz M AU - Soballe, Peter AU - DeNobile, John AU - Cliatt, Janet AU - Nakahara, Kenneth AU - Kirsch, Ilan R AD - Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2253 EP - 2262 VL - 15 IS - 11 SN - 1055-9965, 1055-9965 KW - DNA, Complementary KW - 0 KW - Index Medicus KW - Colonoscopy KW - Oligonucleotide Array Sequence Analysis KW - Humans KW - DNA, Complementary -- metabolism KW - Adult KW - Aged KW - Middle Aged KW - Biopsy KW - Nucleic Acid Hybridization KW - Reverse Transcriptase Polymerase Chain Reaction KW - Male KW - Female KW - Gene Expression Regulation, Neoplastic KW - Colon -- pathology KW - Intestinal Mucosa -- pathology KW - Precancerous Conditions -- diagnosis KW - Gene Expression Regulation KW - Colonic Neoplasms -- pathology KW - Colonic Neoplasms -- diagnosis KW - Precancerous Conditions -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68173185?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Gene+expression+patterns+distinguish+colonoscopically+isolated+human+aberrant+crypt+foci+from+normal+colonic+mucosa.&rft.au=Glebov%2C+Oleg+K%3BRodriguez%2C+Luz+M%3BSoballe%2C+Peter%3BDeNobile%2C+John%3BCliatt%2C+Janet%3BNakahara%2C+Kenneth%3BKirsch%2C+Ilan+R&rft.aulast=Glebov&rft.aufirst=Oleg&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2253&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The epidemiology of second primary cancers. AN - 68169847; 17057028 AB - Due to improvements in early detection, supportive care, and treatment, the number of cancer survivors in the United States has tripled since 1971 and is growing by 2% each year. In 2001, there were approximately 10 million cancer survivors, representing 3.5% of the population. As survival after a diagnosis of cancer improves, quantification of the late effects of cancer and its therapy become critical. One of the most serious events experienced by cancer survivors is the diagnosis of a new cancer. Second- or higher-order cancers now account for approximately 16% of incident cancers reported to the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Subsequent neoplasms may not necessarily be attributable to prior cancer treatment but may also reflect the effect of shared etiologic factors, environmental exposures, host characteristics, and combinations of influences, including gene-environment and gene-gene interactions. This review will focus on selected highlights and recent findings in treatment-associated malignancies, with an emphasis on survivors of adult cancer. Current study methods will also be summarized. Important opportunities for future research include the prospective identification of patient subgroups that might be at heightened susceptibility of developing therapy-associated second cancers to modify planned treatments or select alternative management strategies. For the burgeoning population of cancer survivors treated successfully with past regimens, including those therapies that have been subsequently refined, continued quantification of late effects, including second cancers, remains highly relevant in terms of raising clinician and patient awareness, for informed counseling, and for the development of risk-adapted long-term management strategies. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Executive Plaza South, Suite 7086, Bethesda, MD 20892, USA. duongd@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2020 EP - 2026 VL - 15 IS - 11 SN - 1055-9965, 1055-9965 KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Risk KW - Humans KW - Cohort Studies KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Genetic Predisposition to Disease KW - Male KW - Female KW - Radiotherapy -- adverse effects KW - Antineoplastic Agents -- adverse effects KW - Neoplasms, Second Primary -- epidemiology KW - Neoplasms, Second Primary -- etiology KW - Neoplasms, Second Primary -- diagnosis KW - Neoplasms -- therapy KW - Neoplasms, Second Primary -- prevention & control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68169847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=The+epidemiology+of+second+primary+cancers.&rft.au=Travis%2C+Lois+B&rft.aulast=Travis&rft.aufirst=Lois&rft.date=2006-11-01&rft.volume=15&rft.issue=11&rft.spage=2020&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-12 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of ABCB1 genotypes with paclitaxel-mediated peripheral neuropathy and neutropenia. AN - 68131445; 16950614 AB - Here, we evaluated the relationships between ABCB1 (P-glycoprotein, MDR1) polymorphisms and paclitaxel (Taxol)-induced toxicity and pharmacokinetics. Twenty-six patients were assessable for pharmacogenetics and pharmacokinetics, 22 for neurotoxicity and 18 for myelotoxicity. Patients carrying two reference alleles for the ABCB1 3435C>T polymorphism trended toward a reduced risk to develop neuropathy as compared to patients carrying at least one variant allele (P=0.09). Additionally, patients who were homozygous variant at the 2677 and 3435 loci had a significantly greater percent decrease in absolute neutrophil count at nadir (P=0.02). Neither polymorphism correlated with paclitaxel pharmacokinetics. This pilot study suggests that paclitaxel-induced neuropathy and neutropenia might be linked to inherited variants of ABCB1 through a mechanism that is unrelated to altered plasma pharmacokinetics. JF - European journal of cancer (Oxford, England : 1990) AU - Sissung, Tristan M AU - Mross, Klaus AU - Steinberg, Seth M AU - Behringer, Dirk AU - Figg, William D AU - Sparreboom, Alex AU - Mielke, Stephan AD - Clinical Pharmacology Research Core, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, Bethesda, MD 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2893 EP - 2896 VL - 42 IS - 17 SN - 0959-8049, 0959-8049 KW - ABCB1 protein, human KW - 0 KW - Antineoplastic Agents, Phytogenic KW - Organic Anion Transporters KW - P-Glycoprotein KW - P-Glycoproteins KW - Paclitaxel KW - P88XT4IS4D KW - Index Medicus KW - Genotype KW - Humans KW - Organic Anion Transporters -- genetics KW - Paclitaxel -- adverse effects KW - Antineoplastic Agents, Phytogenic -- adverse effects KW - Polymorphism, Genetic -- genetics KW - Peripheral Nervous System Diseases -- genetics KW - Neutropenia -- chemically induced KW - Neutropenia -- genetics KW - Peripheral Nervous System Diseases -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68131445?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.atitle=Association+of+ABCB1+genotypes+with+paclitaxel-mediated+peripheral+neuropathy+and+neutropenia.&rft.au=Sissung%2C+Tristan+M%3BMross%2C+Klaus%3BSteinberg%2C+Seth+M%3BBehringer%2C+Dirk%3BFigg%2C+William+D%3BSparreboom%2C+Alex%3BMielke%2C+Stephan&rft.aulast=Sissung&rft.aufirst=Tristan&rft.date=2006-11-01&rft.volume=42&rft.issue=17&rft.spage=2893&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+%28Oxford%2C+England+%3A+1990%29&rft.issn=09598049&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Pharmacokinet. 2004;43(9):553-76 [15217301] Cancer Chemother Rep. 1966 Mar;50(3):163-70 [5910392] Blood. 1992 Dec 1;80(11):2729-34 [1360266] Cell. 1994 May 20;77(4):491-502 [7910522] Drug Metab Dispos. 1998 Apr;26(4):343-6 [9531522] Pharmacogenet Genomics. 2005 Oct;15(10):693-704 [16141795] J Clin Pharmacol. 2006 Mar;46(3):373-9 [16490813] Anticancer Drugs. 2003 Nov;14(10):785-92 [14597872] J Clin Oncol. 2002 Jan 15;20(2):574-81 [11786588] Pharmacogenetics. 2001 Jun;11(4):293-8 [11434506] Br J Cancer. 2001 Jan 5;84(1):42-7 [11139311] Recent Results Cancer Res. 1998;144:93-115 [9304712] Proc Natl Acad Sci U S A. 1989 Jan;86(2):695-8 [2563168] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mortality associated with fenbendazole administration in pigeons (Columba livia). AN - 68130083; 17089995 AB - A group of 12 domestic pigeons (Columba livia domestica) was treated for capillariasis by use of fenbendazole at 30 mg/kg orally once daily for 5 d. After treatment, 8 of the 12 pigeons exhibited signs of anorexia, lethargy, and dehydration; these birds died within 2 d after the onset of clinical signs. A total of 6 birds were necropsied, and all had unremarkable gross findings. Microscopic examination of tissues revealed acute hemorrhagic enteritis, diffuse lymphoplasmacytic enteritis, small intestinal crypt necrosis, periportal lymphoplasmacytic hepatitis, bile duct hyperplasia, and renal tubular necrosis. Erythrocytes in blood samples collected from surviving birds demonstrated polychromasia compatible with a regenerative anemia. The clinical and histopathologic findings in these pigeons were consistent with recent reports of fenbendazole toxicity in domestic pigeons and other columbiform birds. JF - Journal of the American Association for Laboratory Animal Science : JAALAS AU - Gozalo, Alfonso S AU - Schwiebert, Rebecca S AU - Lawson, Gregory W AD - Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. gozaloa@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 63 EP - 66 VL - 45 IS - 6 SN - 1559-6109, 1559-6109 KW - Antinematodal Agents KW - 0 KW - Fenbendazole KW - 621BVT9M36 KW - Index Medicus KW - Mortality KW - Animals KW - Liver -- pathology KW - Kidney -- pathology KW - Liver -- drug effects KW - Kidney -- drug effects KW - Intestine, Small -- drug effects KW - Capillaria -- physiology KW - Intestine, Small -- pathology KW - Antinematodal Agents -- administration & dosage KW - Fenbendazole -- adverse effects KW - Fenbendazole -- therapeutic use KW - Antinematodal Agents -- therapeutic use KW - Antinematodal Agents -- adverse effects KW - Fenbendazole -- administration & dosage KW - Columbidae -- parasitology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68130083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.atitle=Mortality+associated+with+fenbendazole+administration+in+pigeons+%28Columba+livia%29.&rft.au=Gozalo%2C+Alfonso+S%3BSchwiebert%2C+Rebecca+S%3BLawson%2C+Gregory+W&rft.aulast=Gozalo&rft.aufirst=Alfonso&rft.date=2006-11-01&rft.volume=45&rft.issue=6&rft.spage=63&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Association+for+Laboratory+Animal+Science+%3A+JAALAS&rft.issn=15596109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-11-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Subjective unmet need for mental health services in depressed children grown up. AN - 68129213; 16823630 AB - Limited attention has been devoted to characterizing unmet need for treatment among individuals with mental disorders. A longitudinal follow-up of depressed, anxious, and psychiatrically normal children into adulthood provided an opportunity to examine factors associated with subjective unmet need. Respondents (n = 208) comprise a subsample of a cohort ascertained between 1977 and 1985 consisting of three subgroups: one with major depressive disorder (MDD), one with anxiety disorders but no MDD, and controls with no psychiatric disorder up to ascertainment. Psychiatric status was reassessed in adulthood using the SADS-LA by interviewers blind to childhood diagnoses. Best-estimate diagnoses describing participants' lifetime clinical course were formulated by senior clinicians. Participants who completed SADS-LA interviews about themselves were invited to complete an additional interview about experiences with health care, including subjective unmet need for and barriers to mental health treatment. About 37% of respondents reported lifetime histories of subjective unmet need for mental health services. Unmet need was associated with female gender and lifetime mood and substance dependence disorders. The most commonly cited barriers included attitudes toward treatment, not knowing where to obtain it, and financial concerns. Subjective unmet need was common in this sample. Approaches to reducing it might include public health initiatives to foster more favorable attitudes toward treatment, increase knowledge of where to obtain it, and lower financial barriers. JF - Administration and policy in mental health AU - Goldstein, Risë B AU - Olfson, Mark AU - Martens, Elaine Goff AU - Wolk, Susan I AD - Division of Clinical-Genetic Epidemiology, Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY, USA. goldster@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 666 EP - 673 VL - 33 IS - 6 SN - 0894-587X, 0894-587X KW - Index Medicus KW - Socioeconomic Factors KW - New York KW - Humans KW - Adult KW - Diagnosis, Dual (Psychiatry) KW - Interviews as Topic KW - Follow-Up Studies KW - Child KW - Adolescent KW - Male KW - Female KW - Substance-Related Disorders -- therapy KW - Anxiety Disorders -- therapy KW - Mental Health Services -- utilization KW - Depressive Disorder, Major -- therapy KW - Needs Assessment KW - Mental Health Services -- organization & administration KW - Health Services Accessibility UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68129213?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Phase+II+trial+of+PN401%2C+5-FU%2C+and+leucovorin+in+unresectable+or+metastatic+adenocarcinoma+of+the+stomach%3A+A+Southwest+Oncology+Group+study&rft.au=Doroshow%2C+James+H%3BMcCoy%2C+Sheryl%3BMacdonald%2C+John+S%3BIssell%2C+Brian+F%3BPatel%2C+Taral%3BCobb%2C+Patrick+W%3BYost%2C+Kathleen+J%3BAbbruzzese%2C+James+L&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2006-11-01&rft.volume=24&rft.issue=6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-006-9244-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-24 N1 - Date created - 2006-11-10 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Higher baseline serum concentrations of vitamin E are associated with lower total and cause-specific mortality in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. AN - 68128364; 17093175 AB - A meta-analysis of 19 trials suggested a small increase in the risk of all-cause mortality with high-dose vitamin E supplementation. Little is known, however, about the relation between mortality and circulating concentrations of vitamin E resulting from dietary intake, low-dose supplementation, or both. We examined whether baseline serum alpha-tocopherol concentrations are associated with total and cause-specific mortality. A prospective cohort study of 29 092 Finnish male smokers aged 50-69 y who participated in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study was carried out. Fasting serum alpha-tocopherol was measured at baseline by using HPLC. Only 10% of participants reported vitamin E supplement use at baseline, and thus serum concentrations of vitamin E mainly reflected dietary intake and other host factors. Risks of total and cause-specific mortality were estimated by using proportional hazards models. During up to 19 y of follow-up, 13 380 deaths (including 4518 and 5776 due to cancer and cardiovascular disease, respectively) were identified. Men in the higher quintiles of serum alpha-tocopherol had significantly lower risks of total and cause-specific mortality than did those in the lowest quintile [relative risk (RR) = 0.82 (95% CI: 0.78, 0.86) for total mortality and 0.79 (0.72, 0.86), 0.81 (0.75, 0.88), and 0.70 (0.63, 0.79) for deaths due to cancer, cardiovascular disease, and other causes, respectively; P for trend for all < 0.0001]. Cubic regression spline analysis of continuous serum alpha-tocopherol values indicated greater risk reductions with increasing concentrations up to approximately 13-14 mg/L, after which no further benefit was noted. Higher circulating concentrations of alpha-tocopherol within the normal range are associated with significantly lower total and cause-specific mortality in older male smokers. JF - The American journal of clinical nutrition AU - Wright, Margaret E AU - Lawson, Karla A AU - Weinstein, Stephanie J AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Nutritional Epidemiology Branch and the Genetic Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. wrighmar@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1200 EP - 1207 VL - 84 IS - 5 SN - 0002-9165, 0002-9165 KW - Vitamin E KW - 1406-18-4 KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Abridged Index Medicus KW - Index Medicus KW - Mortality KW - Odds Ratio KW - alpha-Tocopherol -- blood KW - Dose-Response Relationship, Drug KW - Finland KW - Humans KW - Aged KW - Fasting KW - Cause of Death KW - Smoking KW - Prospective Studies KW - Cohort Studies KW - Chromatography, High Pressure Liquid -- methods KW - Confidence Intervals KW - Middle Aged KW - Dietary Supplements KW - Follow-Up Studies KW - Meta-Analysis as Topic KW - Male KW - Proportional Hazards Models KW - Cardiovascular Diseases -- mortality KW - Neoplasms -- mortality KW - Cardiovascular Diseases -- epidemiology KW - Cardiovascular Diseases -- blood KW - Neoplasms -- blood KW - Neoplasms -- epidemiology KW - Vitamin E -- adverse effects KW - Diet KW - Vitamin E -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68128364?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Higher+baseline+serum+concentrations+of+vitamin+E+are+associated+with+lower+total+and+cause-specific+mortality+in+the+Alpha-Tocopherol%2C+Beta-Carotene+Cancer+Prevention+Study.&rft.au=Wright%2C+Margaret+E%3BLawson%2C+Karla+A%3BWeinstein%2C+Stephanie+J%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Wright&rft.aufirst=Margaret&rft.date=2006-11-01&rft.volume=84&rft.issue=5&rft.spage=1200&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-14 N1 - Date created - 2006-11-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Am J Clin Nutr. 2006 Nov;84(5):959-60 [17093143] Am J Clin Nutr. 2007 Jul;86(1):261-2; author reply 262-4 [17616790] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pilot study of a commercialized human papillomavirus (HPV) genotyping assay: comparison of HPV risk group to cytology and histology. AN - 68122527; 16971652 AB - We evaluated a commercialized PCR assay, Linear Array, that detects 37 human papillomavirus (HPV) genotypes, using a sample of liquid cytology specimens (n = 534). We found a strong association of an increasing level of HPV risk (HPV type 16 [HPV16] > HPV18 > other carcinogenic types > noncarcinogenic types > negative specimens) with increasing severities of cytologic interpretations (P(Trend) < 0.0005) and histologic diagnoses (P(Trend) < 0.0005). JF - Journal of clinical microbiology AU - Castle, Philip E AU - Sadorra, Mark AU - Garcia, Francisco AU - Holladay, E Blair AU - Kornegay, Janet AD - Division of Cancer Epidemiology, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892-7234, USA. castlep@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 3915 EP - 3917 VL - 44 IS - 11 SN - 0095-1137, 0095-1137 KW - Index Medicus KW - Genotype KW - Cytodiagnosis KW - Humans KW - Cervical Intraepithelial Neoplasia -- virology KW - Pilot Projects KW - Female KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- pathology KW - Papillomaviridae -- classification KW - Polymerase Chain Reaction -- methods KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68122527?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+microbiology&rft.atitle=Pilot+study+of+a+commercialized+human+papillomavirus+%28HPV%29+genotyping+assay%3A+comparison+of+HPV+risk+group+to+cytology+and+histology.&rft.au=Castle%2C+Philip+E%3BSadorra%2C+Mark%3BGarcia%2C+Francisco%3BHolladay%2C+E+Blair%3BKornegay%2C+Janet&rft.aulast=Castle&rft.aufirst=Philip&rft.date=2006-11-01&rft.volume=44&rft.issue=11&rft.spage=3915&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-22 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Natl Cancer Inst. 2005 Jul 20;97(14):1072-9 [16030305] Lancet Oncol. 2005 Apr;6(4):204 [15830458] Lancet. 2005 Sep 17-23;366(9490):991-8 [16168781] Am J Clin Pathol. 2005 Nov;124(5):722-32 [16203281] Br J Cancer. 2006 Jan 16;94(1):171-5 [16404371] J Clin Microbiol. 2000 Jan;38(1):357-61 [10618116] J Infect Dis. 2001 Jun 1;183(11):1554-64 [11343204] JAMA. 2002 Oct 9;288(14):1749-57 [12365959] Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1394-9 [12433717] J Natl Cancer Inst. 2003 Jan 1;95(1):46-52 [12509400] N Engl J Med. 2003 Feb 6;348(6):518-27 [12571259] Obstet Gynecol. 2004 Feb;103(2):304-9 [14754700] Obstet Gynecol. 1992 Mar;79(3):328-37 [1310805] J Clin Microbiol. 1998 Oct;36(10):3020-7 [9738060] Int J Cancer. 2005 Nov 1;117(2):177-81 [15900579] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I clinical trial of costimulated, IL-4 polarized donor CD4+ T cells as augmentation of allogeneic hematopoietic cell transplantation. AN - 68113894; 17085308 AB - The primary objective of this clinical trial was to evaluate the safety, feasibility, and biologic effects of administering costimulated, interleukin (IL)-4 polarized donor CD4(+) T cells in the setting of HLA-matched sibling, T cell-replete allogeneic hematopoietic cell transplantation (HCT). Forty-seven subjects with hematologic malignancy received granulocyte colony-stimulating factor-mobilized allogeneic hematopoietic cell transplants and cyclosporine graft-versus-host disease (GVHD) prophylaxis after reduced intensity conditioning. Initial subjects received no additional cells (n = 19); subsequent subjects received additional donor CD4(+) T cells generated ex vivo by CD3/CD28 costimulation in medium containing IL-4 and IL-2 (administered day 1 after HCT at 5, 25, or 125 x 10(6) cells/kg). Studies after HCT included measurement of monocyte IL-1alpha and tumor necrosis factor alpha, detection of T cells with antitumor specificity, and characterization of T cell cytokine phenotype. The culture method generated donor CD4(+) T cells that secreted increased T helper 2 (Th2) cytokines and decreased T helper 1 (Th1) cytokines. Such Th2-like cells were administered without infusional or dose-limiting toxicity. The Th2 cohort had accelerated lymphocyte reconstitution; both cohorts had rapid hematopoietic recovery and alloengraftment. Acute GVHD and overall survival were similar in the Th2 and non-Th2 cohorts. Th2 cell recipients tended to have increased monocyte IL-1alpha and had increased tumor necrosis factor alpha secretion. CD8(+) T cells with antitumor specificity were observed in Th2 and non-Th2 cohorts. Post-transplantation T cells from Th2 cell recipients secreted IL-4 and IL-10 (Th2 cytokines) and IL-2 and interferon gamma (Th1 cytokines). Allograft augmentation with costimulated, IL-4-polarized donor CD4(+) T cells resulted in activated Th1, Th2, and inflammatory cytokine pathways without an apparent increase in GVHD. JF - Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation AU - Fowler, Daniel H AU - Odom, Jeanne AU - Steinberg, Seth M AU - Chow, Catherine K AU - Foley, Jason AU - Kogan, Yelena AU - Hou, Jeannie AU - Gea-Banacloche, Juan AU - Sportes, Claude AU - Pavletic, Steven AU - Leitman, Susan AU - Read, Elizabeth J AU - Carter, Charles AU - Kolstad, Arne AU - Fox, Rebecca AU - Beatty, Gregory L AU - Vonderheide, Robert H AU - Levine, Bruce L AU - June, Carl H AU - Gress, Ronald E AU - Bishop, Michael R AD - Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892, USA. dhfowler@helix.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1150 EP - 1160 VL - 12 IS - 11 SN - 1083-8791, 1083-8791 KW - Cytokines KW - 0 KW - IL4 protein, human KW - Interleukin-4 KW - 207137-56-2 KW - Index Medicus KW - Hematologic Neoplasms -- therapy KW - Humans KW - Adult KW - Aged KW - Transplantation, Homologous -- methods KW - Middle Aged KW - Cytokines -- metabolism KW - Male KW - Female KW - Interleukin-4 -- immunology KW - Interleukin-4 -- pharmacology KW - Th2 Cells -- drug effects KW - CD4-Positive T-Lymphocytes -- immunology KW - Th2 Cells -- transplantation KW - CD4-Positive T-Lymphocytes -- transplantation KW - Graft vs Host Disease -- prevention & control KW - Th2 Cells -- immunology KW - Hematopoietic Stem Cell Transplantation -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68113894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.atitle=Phase+I+clinical+trial+of+costimulated%2C+IL-4+polarized+donor+CD4%2B+T+cells+as+augmentation+of+allogeneic+hematopoietic+cell+transplantation.&rft.au=Fowler%2C+Daniel+H%3BOdom%2C+Jeanne%3BSteinberg%2C+Seth+M%3BChow%2C+Catherine+K%3BFoley%2C+Jason%3BKogan%2C+Yelena%3BHou%2C+Jeannie%3BGea-Banacloche%2C+Juan%3BSportes%2C+Claude%3BPavletic%2C+Steven%3BLeitman%2C+Susan%3BRead%2C+Elizabeth+J%3BCarter%2C+Charles%3BKolstad%2C+Arne%3BFox%2C+Rebecca%3BBeatty%2C+Gregory+L%3BVonderheide%2C+Robert+H%3BLevine%2C+Bruce+L%3BJune%2C+Carl+H%3BGress%2C+Ronald+E%3BBishop%2C+Michael+R&rft.aulast=Fowler&rft.aufirst=Daniel&rft.date=2006-11-01&rft.volume=12&rft.issue=11&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=Biology+of+blood+and+marrow+transplantation+%3A+journal+of+the+American+Society+for+Blood+and+Marrow+Transplantation&rft.issn=10838791&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-23 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines. AN - 68112294; 17085670 AB - Loss of p53 function impairs apoptosis induced by DNA-damaging agents used for cancer therapy. Here, we examined the effect of the heat shock protein 90 (HSP90) inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG) on doxorubicin-induced apoptosis in lymphoma. We aimed to establish the optimal schedule for administration of both drugs in combination and the molecular basis for their interaction. Isogenic lymphoblastoid and nonisogenic lymphoma cell lines differing in p53 status were exposed to each drug or combination. Drug effects were examined using Annexin V, active caspase-3, cell cycle, and cytotoxicity assays. Synergy was evaluated by median effect/combination index. Protein expression and kinase inhibition provided insight into the molecular mechanisms of drug interaction. Presence of mutant p53 conferred increased survival to single agents. Nevertheless, DMAG showed synergistic toxicity with doxorubicin independently of p53 status. Synergy required exposure to doxorubicin before DMAG. DMAG-mediated down-regulation of CHK1, a known HSP90 client, forced doxorubicin-treated cells into premature mitosis followed by apoptosis. A CHK1 inhibitor, SB-218078, reproduced the effect of DMAG. Administration of DMAG before doxorubicin resulted in G1-S arrest and protection from apoptosis, leading to additive or antagonistic interactions that were exacerbated by p53 mutation. Administration of DMAG to doxorubicin-primed cells induced premature mitosis and had a synergistic effect on apoptosis regardless of p53 status. These observations provide a rationale for prospective clinical trials and stress the need to consider schedule of exposure as a critical determinant of the overall response when DMAG is combined with chemotherapeutic agents for the treatment of patients with relapsed/refractory disease. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Robles, Ana I AU - Wright, Mollie H AU - Gandhi, Bheru AU - Feis, Steven S AU - Hanigan, Christin L AU - Wiestner, Adrian AU - Varticovski, Lyuba AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute and Hematology Branch, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA. roblesa@mail.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 6547 EP - 6556 VL - 12 IS - 21 SN - 1078-0432, 1078-0432 KW - Benzoquinones KW - 0 KW - HSP90 Heat-Shock Proteins KW - Lactams, Macrocyclic KW - Tumor Suppressor Protein p53 KW - 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin KW - 001L2FE0M3 KW - Doxorubicin KW - 80168379AG KW - Index Medicus KW - Immunoblotting KW - Drug Administration Schedule KW - Humans KW - Drug Resistance, Neoplasm -- genetics KW - Apoptosis -- drug effects KW - HSP90 Heat-Shock Proteins -- antagonists & inhibitors KW - Cell Line, Tumor KW - Drug Synergism KW - Mutation KW - Cell Cycle -- drug effects KW - Doxorubicin -- pharmacology KW - Benzoquinones -- pharmacology KW - Lymphoma -- drug therapy KW - Lactams, Macrocyclic -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Tumor Suppressor Protein p53 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68112294?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Schedule-dependent+synergy+between+the+heat+shock+protein+90+inhibitor+17-%28dimethylaminoethylamino%29-17-demethoxygeldanamycin+and+doxorubicin+restores+apoptosis+to+p53-mutant+lymphoma+cell+lines.&rft.au=Robles%2C+Ana+I%3BWright%2C+Mollie+H%3BGandhi%2C+Bheru%3BFeis%2C+Steven+S%3BHanigan%2C+Christin+L%3BWiestner%2C+Adrian%3BVarticovski%2C+Lyuba&rft.aulast=Robles&rft.aufirst=Ana&rft.date=2006-11-01&rft.volume=12&rft.issue=21&rft.spage=6547&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma. AN - 68110277; 17079483 AB - Human primary intraocular lymphoma (PIOL) is predominantly a B cell-originated malignant disease with no appropriate animal models and effective therapies available. This study aimed to establish a mouse model to closely mimic human B-cell PIOL and to test the therapeutic potential of a recently developed immunotoxin targeting human B-cell lymphomas. Human B-cell lymphoma cells were intravitreally injected into severe combined immunodeficient mice. The resemblance of this tumor model to human PIOL was examined by fundoscopy, histopathology, immunohistochemistry, and evaluated for molecular markers. The therapeutic effectiveness of immunotoxin HA22 was tested by injecting the drug intravitreally. Results showed that the murine model resembles human PIOL closely. Pathologic examination revealed that the tumor cells initially colonized on the retinal surface, followed by infiltrating through the retinal layers, expanding preferentially in the subretinal space, and eventually penetrating through the retinal pigment epithelium into the choroid. Several putative molecular markers for human PIOL were expressed in vivo in this model. Tumor metastasis into the central nervous system was also observed. A single intravitreal injection of immunotoxin HA22 after the establishment of the PIOL resulted in complete regression of the tumor. This is the first report of a murine model that closely mimics human B-cell PIOL. This model may be a valuable tool in understanding the molecular pathogenesis of human PIOL and for the evaluation of new therapeutic approaches. The results of B cell-specific immunotoxin therapy may have clinical implications in treating human PIOL. JF - Cancer research AU - Li, Zhuqing AU - Mahesh, Sankaranarayana P AU - Shen, De Fen AU - Liu, Baoying AU - Siu, Willie O AU - Hwang, Frank S AU - Wang, Qing-Chen AU - Chan, Chi-Chao AU - Pastan, Ira AU - Nussenblatt, Robert B AD - Laboratory of Immunology, National Eye Institute and Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10586 EP - 10593 VL - 66 IS - 21 SN - 0008-5472, 0008-5472 KW - CD22 protein, human KW - 0 KW - CXCR5 protein, human KW - Immunotoxins KW - Receptors, CXCR4 KW - Receptors, CXCR5 KW - Receptors, Chemokine KW - Sialic Acid Binding Ig-like Lectin 2 KW - Index Medicus KW - Receptors, Chemokine -- analysis KW - Neoplasm Invasiveness KW - Animals KW - Humans KW - Disease Models, Animal KW - Mice KW - Cell Line, Tumor KW - Mice, SCID KW - Sialic Acid Binding Ig-like Lectin 2 -- analysis KW - Receptors, CXCR4 -- analysis KW - Eye Neoplasms -- therapy KW - B-Lymphocytes -- drug effects KW - Lymphoma, B-Cell -- therapy KW - Lymphoma, B-Cell -- immunology KW - Lymphoma, B-Cell -- pathology KW - Immunotoxins -- therapeutic use KW - Eye Neoplasms -- pathology KW - Eye Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Eradication+of+tumor+colonization+and+invasion+by+a+B+cell-specific+immunotoxin+in+a+murine+model+for+human+primary+intraocular+lymphoma.&rft.au=Li%2C+Zhuqing%3BMahesh%2C+Sankaranarayana+P%3BShen%2C+De+Fen%3BLiu%2C+Baoying%3BSiu%2C+Willie+O%3BHwang%2C+Frank+S%3BWang%2C+Qing-Chen%3BChan%2C+Chi-Chao%3BPastan%2C+Ira%3BNussenblatt%2C+Robert+B&rft.aulast=Li&rft.aufirst=Zhuqing&rft.date=2006-11-01&rft.volume=66&rft.issue=21&rft.spage=10586&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer. 1997 Jun 15;79(12):2409-13 [9191531] Arch Ophthalmol. 1997 Sep;115(9):1157-60 [9298057] Clin Cancer Res. 2005 Feb 15;11(4):1545-50 [15746059] J Neuroophthalmol. 2005 Mar;25(1):33-6 [15756131] Hematol Oncol Clin North Am. 2005 Aug;19(4):739-49, viii [16083834] Clin Cancer Res. 2000 Apr;6(4):1476-87 [10778980] Curr Opin Oncol. 2001 May;13(3):137-42 [11307054] N Engl J Med. 2001 Jul 26;345(4):241-7 [11474661] Vision Res. 2002 Feb;42(4):487-95 [11853765] Curr Mol Med. 2001 May;1(2):259-72 [11899075] J Leukoc Biol. 2002 Jul;72(1):1-8 [12101256] Cancer. 2002 Jul 1;95(1):193-202 [12115333] Curr Opin Ophthalmol. 2002 Dec;13(6):411-8 [12441846] Blood. 2003 Feb 1;101(3):815-21 [12393412] Ophthalmology. 2003 Feb;110(2):421-6 [12578791] Methods Mol Biol. 2004;248:503-18 [14970517] Trans Am Ophthalmol Soc. 2003;101:275-92 [14971583] Ocul Immunol Inflamm. 2004 Mar;12(1):7-16 [15209459] J Leukoc Biol. 2004 Aug;76(2):462-71 [15155773] Can J Ophthalmol. 1986 Jun;21(4):144-9 [3755372] Ophthalmology. 1988 May;95(5):625-30 [3050698] Cancer. 1988 Dec 1;62(11):2461-5 [3179963] Science. 1991 Nov 22;254(5035):1173-7 [1683495] Cancer. 1993 Aug 1;72(3):843-9 [8334638] Invest Ophthalmol Vis Sci. 1999 Sep;40(10):2462-3 [10476821] Ophthalmology. 1999 Sep;106(9):1805-10 [10485554] Clin Cancer Res. 1999 Sep;5(9):2311-5 [10499598] Graefes Arch Clin Exp Ophthalmol. 2004 Nov;242(11):901-13 [15565454] Curr Oncol Rep. 2005 Jan;7(1):74-9 [15610690] Invest Ophthalmol Vis Sci. 2005 Feb;46(2):415-9 [15671263] J Biol Chem. 1994 Jul 15;269(28):18327-31 [7913461] Recent Results Cancer Res. 1994;135:155-69 [8047690] J Natl Cancer Inst. 1996 May 15;88(10):675-9 [8627644] Br J Ophthalmol. 1997 Jan;81(1):31-6 [9135405] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression. AN - 68110048; 17039256 AB - Overexpression of pituitary tumor-transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma (TRbeta(PV/PV) mice). Here we examined the molecular mechanisms underlying elevated PTTG1 levels and the contribution of increased PTTG1 to thyroid carcinogenesis. We showed that PTTG1 was physically associated with thyroid hormone beta receptor (TRbeta) as well as its mutant, designated PV. Concomitant with thyroid hormone-induced (T3-induced) degradation of TRbeta, PTTG1 proteins were degraded by the proteasomal machinery, but no such degradation occurred when PTTG1 was associated with PV. The degradation of PTTG1/TRbeta was activated by the direct interaction of the liganded TRbeta with steroid receptor coactivator 3 (SRC-3), which recruits proteasome activator PA28gamma. PV, which does not bind T3, could not interact directly with SRC-3/PA28gamma to activate proteasome degradation, resulting in elevated PTTG1 levels. The accumulated PTTG1 impeded mitotic progression in cells expressing PV. Our results unveil what we believe to be a novel mechanism by which PTTG1, an oncogene, is regulated by the liganded TRbeta. The loss of this regulatory function in PV led to an aberrant accumulation of PTTG1 disrupting mitotic progression that could contribute to thyroid carcinogenesis. JF - The Journal of clinical investigation AU - Ying, Hao AU - Furuya, Fumihiko AU - Zhao, Li AU - Araki, Osamu AU - West, Brian L AU - Hanover, John A AU - Willingham, Mark C AU - Cheng, Sheue-Yann AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 2972 EP - 2984 VL - 116 IS - 11 SN - 0021-9738, 0021-9738 KW - Ligands KW - 0 KW - Neoplasm Proteins KW - RNA, Small Interfering KW - Securin KW - Thyroid Hormone Receptors beta KW - Proteasome Endopeptidase Complex KW - EC 3.4.25.1 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Cell Transformation, Neoplastic -- pathology KW - Thyroid Neoplasms -- genetics KW - Thyroid Neoplasms -- metabolism KW - Cell Transformation, Neoplastic -- metabolism KW - Mice KW - RNA, Small Interfering -- genetics KW - Mice, Transgenic KW - Protein Binding KW - Proteasome Endopeptidase Complex -- metabolism KW - Mutation -- genetics KW - Thyroid Neoplasms -- pathology KW - Cell Line KW - Cell Transformation, Neoplastic -- genetics KW - Thyroid Hormone Receptors beta -- metabolism KW - Mitosis KW - Neoplasm Proteins -- genetics KW - Thyroid Hormone Receptors beta -- genetics KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68110048?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Functional+Compensation+for+Adipose+Differentiation-related+Protein+%28ADFP%29+by+Tip47+in+an+ADFP+Null+Embryonic+Cell+Line&rft.au=Sztalryd%2C+Carole%3BBell%2C+Ming%3BLu%2C+Xinyue%3BMertz%2C+Pamela%3BHickenbottom%2C+Sabrina%3BChang%2C+Benny+H-J%3BChan%2C+Lawrence%3BKimmel%2C+Alan+R%3BLondos%2C+Constantine&rft.aulast=Sztalryd&rft.aufirst=Carole&rft.date=2006-11-01&rft.volume=281&rft.issue=45&rft.spage=34341&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 2000 Jan 20;19(3):403-9 [10656688] Cell. 2006 Jan 27;124(2):381-92 [16439211] Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8985-90 [10908671] Mol Endocrinol. 2000 Aug;14(8):1137-46 [10935539] J Biol Chem. 2000 Nov 24;275(47):36502-5 [11013229] Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14 [11069286] Brain Pathol. 2001 Jul;11(3):328-41 [11414475] Mol Cell Biol. 2001 Oct;21(20):6782-95 [11564863] J Clin Endocrinol Metab. 2001 Oct;86(10):5025-32 [11600580] Mol Endocrinol. 2002 Sep;16(9):2077-92 [12198244] Thyroid. 2002 Nov;12(11):963-9 [12490073] Genes Chromosomes Cancer. 2003 Mar;36(3):292-302 [12557229] Cancer Genet Cytogenet. 2003 Feb;141(1):26-31 [12581895] Trends Endocrinol Metab. 2003 Sep;14(7):327-33 [12946875] Carcinogenesis. 2003 Sep;24(9):1467-79 [12869418] Clin Otolaryngol Allied Sci. 2003 Oct;28(5):386-95 [12969338] Cancer Res. 2003 Sep 1;63(17):5274-80 [14500358] Endocrinology. 2003 Nov;144(11):4991-8 [12960092] Methods Enzymol. 2003;364:257-84 [14631850] Arch Biochem Biophys. 2004 May 15;425(2):158-64 [15111123] J Biol Chem. 2004 Aug 6;279(32):33909-18 [15166217] Mol Endocrinol. 1991 Apr;5(4):485-92 [1922081] J Clin Invest. 1991 Dec;88(6):2123-30 [1661299] Mol Endocrinol. 1992 Feb;6(2):248-58 [1569968] Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7737-41 [1502193] J Clin Invest. 1993 Oct;92(4):1986-93 [8408652] Biochemistry. 1995 Aug 22;34(33):10591-9 [7544615] Mol Endocrinol. 1997 Apr;11(4):433-41 [9092795] Genes Chromosomes Cancer. 1997 May;19(1):43-51 [9135994] Cell. 1998 Apr 3;93(1):81-91 [9546394] Oncogene. 1998 Oct 29;17(17):2187-93 [9811450] J Clin Endocrinol Metab. 1999 Feb;84(2):761-7 [10022450] Science. 1999 Jul 16;285(5426):418-22 [10411507] Mol Cell Biol. 2005 Jan;25(1):124-35 [15601836] Trends Biochem Sci. 2005 Mar;30(3):126-32 [15752984] Trends Endocrinol Metab. 2005 May-Jun;16(4):176-82 [15860414] Oncogene. 2005 Jul 14;24(30):4861-6 [15897900] Cancer Genet Cytogenet. 2005 Sep;161(2):104-9 [16102579] Cancer Treat Res. 2004;122:85-105 [16209039] Lancet. 2000 Feb 26;355(9205):716-9 [10703804] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. AN - 68107071; 17021608 AB - Urinary exosomes containing apical membrane and intracellular fluid are normally secreted into the urine from all nephron segments, and may carry protein markers of renal dysfunction and structural injury. We aimed to discover biomarkers in urinary exosomes to detect acute kidney injury (AKI), which has a high mortality and morbidity. Animals were injected with cisplatin. Urinary exosomes were isolated by differential centrifugation. Protein changes were evaluated by two-dimensional difference in gel electrophoresis and changed proteins were identified by mass spectrometry. The identified candidate biomarkers were validated by Western blotting in individual urine samples from rats subjected to cisplatin injection; bilateral ischemia and reperfusion (I/R); volume depletion; and intensive care unit (ICU) patients with and without AKI. We identified 18 proteins that were increased and nine proteins that were decreased 8 h after cisplatin injection. Most of the candidates could not be validated by Western blotting. However, exosomal Fetuin-A increased 52.5-fold at day 2 (1 day before serum creatinine increase and tubule damage) and remained elevated 51.5-fold at day 5 (peak renal injury) after cisplatin injection. By immunoelectron microscopy and elution studies, Fetuin-A was located inside urinary exosomes. Urinary Fetuin-A was increased 31.6-fold in the early phase (2-8 h) of I/R, but not in prerenal azotemia. Urinary exosomal Fetuin-A also increased in three ICU patients with AKI compared to the patients without AKI. We conclude that (1) proteomic analysis of urinary exosomes can provide biomarker candidates for the diagnosis of AKI and (2) urinary Fetuin-A might be a predictive biomarker of structural renal injury. JF - Kidney international AU - Zhou, H AU - Pisitkun, T AU - Aponte, A AU - Yuen, P S T AU - Hoffert, J D AU - Yasuda, H AU - Hu, X AU - Chawla, L AU - Shen, R-F AU - Knepper, M A AU - Star, R A AD - Renal Diagnostics and Therapeutics Unit, NIDDK, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1847 EP - 1857 VL - 70 IS - 10 SN - 0085-2538, 0085-2538 KW - AHSG protein, human KW - 0 KW - Antineoplastic Agents KW - Biomarkers KW - Blood Proteins KW - alpha-2-HS-Glycoprotein KW - alpha-Fetoproteins KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Models, Animal KW - Animals KW - Kidney -- pathology KW - alpha-Fetoproteins -- urine KW - Humans KW - Kidney -- drug effects KW - Aged KW - Biomarkers -- urine KW - Antineoplastic Agents -- adverse effects KW - Rats KW - Aged, 80 and over KW - Kidney -- injuries KW - Adult KW - Cisplatin -- pharmacology KW - Middle Aged KW - Cell Membrane -- metabolism KW - Cisplatin -- adverse effects KW - Antineoplastic Agents -- pharmacology KW - Male KW - Female KW - Reperfusion Injury -- etiology KW - Proteomics -- methods KW - Acute Kidney Injury -- pathology KW - Blood Proteins -- urine KW - Acute Kidney Injury -- etiology KW - Reperfusion Injury -- urine KW - Reperfusion Injury -- pathology KW - Acute Kidney Injury -- urine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107071?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Exosomal+Fetuin-A+identified+by+proteomics%3A+a+novel+urinary+biomarker+for+detecting+acute+kidney+injury.&rft.au=Zhou%2C+H%3BPisitkun%2C+T%3BAponte%2C+A%3BYuen%2C+P+S+T%3BHoffert%2C+J+D%3BYasuda%2C+H%3BHu%2C+X%3BChawla%2C+L%3BShen%2C+R-F%3BKnepper%2C+M+A%3BStar%2C+R+A&rft.aulast=Zhou&rft.aufirst=H&rft.date=2006-11-01&rft.volume=70&rft.issue=10&rft.spage=1847&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-08 N1 - Date created - 2006-11-02 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: N Engl J Med. 1996 May 30;334(22):1448-60 [8618585] Am J Physiol. 1996 Sep;271(3 Pt 2):F477-88 [8853409] Am J Kidney Dis. 1997 May;29(5):793-9 [9159318] Anat Embryol (Berl). 1998 Feb;197(2):125-33 [9497155] Kidney Int. 1998 Dec;54(6):1817-31 [9853246] Am J Transplant. 2005 Apr;5(4 Pt 1):729-38 [15760396] Proteomics. 2005 Mar;5(4):1033-42 [15669002] J Clin Invest. 2005 Mar;115(3):610-21 [15711640] Lancet. 2005 Apr 2-8;365(9466):1231-8 [15811456] Kidney Int. 2005 Jun;67(6):2159-67 [15882259] Nephrology (Carlton). 2005 Jun;10(3):283-90 [15958043] Ther Apher Dial. 2005 Jun;9(3):208-10 [15966990] Clin Chim Acta. 2005 Jul 24;357(2):151-8 [15896729] J Am Soc Nephrol. 2005 Oct;16(10):2920-30 [16093453] J Am Soc Nephrol. 2005 Oct;16(10):3046-52 [16148039] Am J Physiol Renal Physiol. 2006 Feb;290(2):F517-29 [16174863] Diabetes Care. 2006 Feb;29(2):468 [16443916] Nephrol Dial Transplant. 2006 Mar;21(3):616-23 [16384831] Am J Pathol. 1992 Apr;140(4):831-8 [1562048] Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13368-73 [15326289] Am J Nephrol. 2004 May-Jun;24(3):307-15 [15148457] Clin Chem. 2004 Mar;50(3):552-8 [14709451] Am J Kidney Dis. 2004 Mar;43(3):405-14 [14981598] Diabetes Care. 2006 Apr;29(4):853-7 [16567827] Am J Physiol Renal Physiol. 2004 Mar;286(3):F552-63 [14600030] Am J Physiol Renal Physiol. 2004 Jan;286(1):F170-9 [12965894] Nephron Exp Nephrol. 2003;95(2):e69-78 [14610326] J Am Soc Nephrol. 2003 Oct;14(10):2534-43 [14514731] Am J Kidney Dis. 2003 Sep;42(3):497-506 [12955677] J Clin Invest. 2003 Aug;112(3):357-66 [12897203] Lancet. 2003 Mar 8;361(9360):827-33 [12642050] Clin Biochem. 2002 Nov;35(8):581-9 [12498991] Kidney Int. 2002 Nov;62(5):1601-10 [12371960] Kidney Int. 2002 Oct;62(4):1461-9 [12234320] Am J Physiol Renal Physiol. 2006 May;290(5):F1187-93 [16368740] Kidney Int. 2006 Apr;69(8):1471-6 [16501490] Proc Natl Acad Sci U S A. 2006 May 2;103(18):7159-64 [16641100] Kidney Int. 2006 Jul;70(1):199-203 [16710348] Kidney Int. 2006 Aug;70(3):496-506 [16760904] J Lab Clin Med. 1999 Dec;134(6):649-58 [10595794] Blood Purif. 2001;19(2):233-7 [11150816] Shock. 2001 Mar;15(3):181-5 [11236900] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Household Work Complexity, Intellectual Functioning, and Self-Esteem in Men and Women AN - 61677945; 200717434 AB - Using data from a U.S. longitudinal investigation of psychological effects of occupational conditions (a project of the National Institute of Mental Health's unit on Socioenvironmental Studies), we examined the relationship between the complexity of household work & 2 psychological variables: intellectual flexibility & self-esteem. Longitudinal reciprocal effects analyses revealed that for men (n = 351) & women (n = 355), more complex household work was associated with increased intellectual flexibility. For women, complex household work was also associated with increased self-confidence & decreased self-deprecation. For men, complex household work was associated with decreased self-confidence. The results are discussed in terms of theories of the cognitive & neurological effects of environmental complexity & of theories of self-esteem. Tables, Figures, References. Adapted from the source document. JF - Journal of Marriage and Family AU - Caplan, Leslie J AU - Schooler, Carmi AD - Section Socioenvironmental Studies, National Instit Mental Health, Bethesda, MD leslie.caplan@nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 883 EP - 900 PB - Blackwell Publishers, Malden MA VL - 68 IS - 4 SN - 0022-2445, 0022-2445 KW - family roles, housework/division of labor, personality, self-esteem KW - Self Esteem KW - Housework KW - Working Women KW - Working Men KW - Flexibility KW - Sex Differences KW - Cognitive Functioning KW - Home Environment KW - Sexual Division of Labor KW - article KW - 1941: the family and socialization; sociology of the family, marriage, & divorce UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61677945?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Marriage+and+Family&rft.atitle=Household+Work+Complexity%2C+Intellectual+Functioning%2C+and+Self-Esteem+in+Men+and+Women&rft.au=Caplan%2C+Leslie+J%3BSchooler%2C+Carmi&rft.aulast=Caplan&rft.aufirst=Leslie&rft.date=2006-11-01&rft.volume=68&rft.issue=4&rft.spage=883&rft.isbn=&rft.btitle=&rft.title=Journal+of+Marriage+and+Family&rft.issn=00222445&rft_id=info:doi/ LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-02 N1 - Last updated - 2016-09-28 N1 - CODEN - JMFAA6 N1 - SubjectsTermNotLitGenreText - Housework; Self Esteem; Working Men; Working Women; Sexual Division of Labor; Sex Differences; Cognitive Functioning; Flexibility; Home Environment ER - TY - JOUR T1 - Childhood onset schizophrenia: cortical brain abnormalities as young adults AN - 57197201; 200713078 AB - Background: Childhood onset schizophrenia (COS) is a rare but severe form of the adult onset disorder. While structural brain imaging studies show robust, widespread, and progressive gray matter loss in COS during adolescence, there have been no longitudinal studies of sufficient duration to examine comparability with the more common adult onset illness. Methods: Neuro-anatomic magnetic resonance scans were obtained prospectively from ages 7 through 26 in 70 children diagnosed with COS and age and sex matched healthy controls. Cortical thickness was measured at 40,962 points across the cerebral hemispheres using a novel, fully automated, validated method. Patterns of patient-control differences in cortical development were compared over a 19-year period. Results: Throughout the age range, the COS group had significantly smaller mean cortical thickness compared to controls. However, the COS brain developmental trajectory appeared to normalize in posterior (parietal) regions, and remained divergent in the anterior regions (frontal and temporal) regions, and the pattern of loss became more like that seen in adults. Conclusions: Cortical thickness loss in COS appears to localize with age to prefrontal and temporal regions that are seen for both medication naive and medicated adult onset patients. Tables, Figures. Adapted from the source document. JF - The Journal of Child Psychology and Psychiatry and Allied Disciplines AU - Greenstein, Deanna AU - Lerch, Jason AU - Shaw, Philip AU - Clasen, Liv AU - Giedd, Jay AU - Gochman, Peter AU - Rapoport, Judith AU - Gogtay, Nitin AD - Child Psychiatry Branch, NIMH/NIH, Bethesda, MD Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1003 EP - 1012 PB - Blackwell Publishing, Oxford UK VL - 47 IS - 10 SN - 0021-9630, 0021-9630 KW - Childhood onset schizophrenia KW - MRI KW - cortical thickness KW - development KW - neurodevelopment KW - schizophrenia KW - Schizophrenia KW - Neurodevelopmental aspects KW - Prospective studies KW - Magnetic resonance imaging KW - Comparative research KW - Childhood onset KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57197201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.atitle=Childhood+onset+schizophrenia%3A+cortical+brain+abnormalities+as+young+adults&rft.au=Greenstein%2C+Deanna%3BLerch%2C+Jason%3BShaw%2C+Philip%3BClasen%2C+Liv%3BGiedd%2C+Jay%3BGochman%2C+Peter%3BRapoport%2C+Judith%3BGogtay%2C+Nitin&rft.aulast=Greenstein&rft.aufirst=Deanna&rft.date=2006-11-01&rft.volume=47&rft.issue=10&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Child+Psychology+and+Psychiatry+and+Allied+Disciplines&rft.issn=00219630&rft_id=info:doi/10.1111%2Fj.1469-7610.2006.01658.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-07-31 N1 - Last updated - 2016-09-27 N1 - CODEN - JPPDAI N1 - SubjectsTermNotLitGenreText - Schizophrenia; Childhood onset; Comparative research; Magnetic resonance imaging; Neurodevelopmental aspects; Prospective studies DO - http://dx.doi.org/10.1111/j.1469-7610.2006.01658.x ER - TY - JOUR T1 - Leptin As a Marker of Body Fat and Hyperinsulinemia in College Students AN - 57139368; 200705264 AB - Little is known about obesity & insulin resistance in college students. Leptin is a hormone secreted by fat cells & has been shown to strongly correlate with both obesity & insulin resistance in children & adults. We investigated associations of leptin with insulin secretion & action in 119 normal-weight students aged 18-24 years. Leptin was strongly correlated with total fat mass (r = .67, p < .001), percentage body fat (r = .81, p < .001), & to a lesser degree Body Mass Index, or BMI, (r = .23, p < .02). Leptin was associated with fasting insulin (b - SE = 0.30 - 0.06, p < .001) & insulin resistance (b - SE = 0.41 - 0.20, p < .001) independent of total fat, gender, & age, suggesting other mechanisms of leptin & insulin regulation besides obesity. Leptin resistance is present even among young & normal-weight college students. Leptin, even more so than BMI, is an important marker of adiposity & hyperinsulinemia in normal-weight college students & may potentially be used to predict type 2 diabetes. Tables, References. Adapted from the source document. JF - Journal of American College Health AU - Kempf, Angela M AU - Strother, Myra L AU - Li, Chaoyang AU - Kaur, Harsohena AU - Huang, Terry T.-K. AD - c/o Huang -- Endocrinology/Nutrition/Growth Branch, Center Research Mothers & Children, National Instit Child Health & Human Development, Rockville, MD Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 175 EP - 180 PB - Heldref Publications, Washington DC VL - 55 IS - 3 SN - 0744-8481, 0744-8481 KW - insulin resistance, insulin secretion, leptin, obesity KW - Obesity KW - Resistance KW - Body fat KW - Insulin KW - Undergraduate students KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57139368?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+American+College+Health&rft.atitle=Leptin+As+a+Marker+of+Body+Fat+and+Hyperinsulinemia+in+College+Students&rft.au=Kempf%2C+Angela+M%3BStrother%2C+Myra+L%3BLi%2C+Chaoyang%3BKaur%2C+Harsohena%3BHuang%2C+Terry+T.-K.&rft.aulast=Kempf&rft.aufirst=Angela&rft.date=2006-11-01&rft.volume=55&rft.issue=3&rft.spage=175&rft.isbn=&rft.btitle=&rft.title=Journal+of+American+College+Health&rft.issn=07448481&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Undergraduate students; Insulin; Obesity; Body fat; Resistance ER - TY - JOUR T1 - Changes in Genetic and Environmental Influences on Depressive Symptoms across Adolescence and Young Adulthood AN - 57110724; 200704092 AB - Background: Depression rises markedly in adolescence, a time when increased & new genetic influences have been reported. Aims: To examine 'new' & 'stable' genetic & environmental factors on depressive symptoms in adolescence & young adulthood. Method: Aquestionnaire survey investigated a sample of twin & sibling pairs at three time points over an approximately 3-year period. Over 1800 twin & sibling pairs reported depressive symptoms at the three time points. Data were analysed using multivariate genetic models. Results: Depressive symptoms at all time points were moderately heritable with substantial non-shared environmental contributions. Wave 1 genetic factors accounted for continuity of symptoms at waves 2 & 3. 'New' genetic effects at wave 2 also influenced wave 3 symptoms. New non-shared environmental influences emerged at each time point. Conclusions: New genetic & environmental influences may explain age-related increases in depression across development. Tables, Figures, References. Adapted from the source document. JF - The British Journal of Psychiatry AU - Lau, Jennifer Y F AU - Eley, Thalia C AD - National Instit Health, Bethesda, MD lauj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 422 EP - 427 PB - Royal College of Psychiatrists, London UK VL - 189 SN - 0007-1250, 0007-1250 KW - Genetic factors KW - Depression KW - Environmental aspects KW - Familial factors KW - Young adults KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110724?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Changes+in+Genetic+and+Environmental+Influences+on+Depressive+Symptoms+across+Adolescence+and+Young+Adulthood&rft.au=Lau%2C+Jennifer+Y+F%3BEley%2C+Thalia+C&rft.aulast=Lau&rft.aufirst=Jennifer+Y&rft.date=2006-11-01&rft.volume=189&rft.issue=&rft.spage=422&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.105.018721 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Adolescents; Young adults; Depression; Genetic factors; Familial factors; Environmental aspects DO - http://dx.doi.org/10.1192/bjp.bp.105.018721 ER - TY - JOUR T1 - Association of Executive Function and Performance of Dual-Task Physical Tests among Older Adults: Analyses from the InChianti Study AN - 57110055; 200703769 AB - Background: previous studies have reported an association between cognitive function & physical performance, particularly among older adults. Objective: to examine the association between executive function & performance difference on complex versus usual walking tasks in a sample of non-demented older adults. Design: population-based epidemiological study of older people residing in the Chianti area (Tuscany, Italy). Participants: 737 community-dwelling individuals aged 65 years & older. Methods: gait speed (m/s) was measured during the performance of complex walking tasks (walking/talking, walking/picking-up an object, walking/carrying a large package, walking over obstacles, walking with a weighted vest) & reference walking tasks (7 m usual pace, 7 m fast pace & 60 m fast pace). Executive function was assessed using the Trail Making Test (TMT). Other measures included Mini-Mental State Examination (MMSE), sociodemographic characteristics & selected physiological impairments. Results: gait speed for the selected reference & complex walk tasks was consistently lower among participants with poor executive function. Per cent decline in gait speed compared with the reference task differed by executive function for certain tasks (e.g. walking/obstacles: 30 versus 24% decline in low versus high executive function respectively, P = 0.0006) but not for others. Conclusions: poor executive function is associated with measures of gait, including specific challenges. Overall, the results showed that the cost associated with the addition of a challenge to the basic walking task differs by executive function & the nature of the task. Further research is needed to determine whether improvement in executive function abilities translates to better performance on selected complex walking tasks. Tables, References. Adapted from the source document. JF - Age and Ageing AU - Coppin, Antonia K AU - Shumway-Cook, Anne AU - Saczynski, Jane S AU - Patel, Kushang V AU - Ble, Alessandro AU - Ferrucci, Luigi AU - Guralnik, Jack M AD - National Instit Aging, National Instit Health, Bethesda, MD coppina@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 619 EP - 624 PB - Oxford University Press, UK VL - 35 IS - 6 SN - 0002-0729, 0002-0729 KW - executive function, older adults, physical performance KW - dual tasks KW - mobility KW - elderly KW - Elderly people KW - Mobility KW - Physical activity KW - Gait KW - Walking speed KW - Executive function KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57110055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Age+and+Ageing&rft.atitle=Association+of+Executive+Function+and+Performance+of+Dual-Task+Physical+Tests+among+Older+Adults%3A+Analyses+from+the+InChianti+Study&rft.au=Coppin%2C+Antonia+K%3BShumway-Cook%2C+Anne%3BSaczynski%2C+Jane+S%3BPatel%2C+Kushang+V%3BBle%2C+Alessandro%3BFerrucci%2C+Luigi%3BGuralnik%2C+Jack+M&rft.aulast=Coppin&rft.aufirst=Antonia&rft.date=2006-11-01&rft.volume=35&rft.issue=6&rft.spage=619&rft.isbn=&rft.btitle=&rft.title=Age+and+Ageing&rft.issn=00020729&rft_id=info:doi/10.1093%2Fageing%2Fafl107 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Elderly people; Walking speed; Gait; Mobility; Physical activity; Executive function DO - http://dx.doi.org/10.1093/ageing/afl107 ER - TY - JOUR T1 - Possible Selves and Proximal Goals for the Academy AN - 57092803; 200703249 AB - This article features the 2006 Presidential inaugural address presented at the American Academy of Health Behavior Annual Meeting by Bruce Simons-Morton. Dr. Simons-Morton proposes several organizational goals for the Academy. Tables. Adapted from the source document. JF - American Journal of Health Behavior AU - Simons-Morton, Bruce AD - Prevention Research Branch, Division Statistics/Epidemiology/Prevention Research, National Instit Child Heal mortonb@nail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 598 EP - 601 PB - PNG Publications, Star City WV VL - 30 IS - 6 SN - 1087-3244, 1087-3244 KW - Goals KW - Professional associations KW - Conferences KW - Speeches KW - Health behaviour KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092803?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Health+Behavior&rft.atitle=Possible+Selves+and+Proximal+Goals+for+the+Academy&rft.au=Simons-Morton%2C+Bruce&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2006-11-01&rft.volume=30&rft.issue=6&rft.spage=598&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Health+Behavior&rft.issn=10873244&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - CODEN - AJHBF6 N1 - SubjectsTermNotLitGenreText - Conferences; Health behaviour; Professional associations; Speeches; Goals ER - TY - JOUR T1 - Decision Making about Children with Psychotic Symptoms: Using the Best Evidence in Choosing a Treatment AN - 57088081; 200703229 AB - This article examines the decision making involved to treat children diagnosed with psychosis & childhood schizophrenia. Tables, References. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Shaw, Philip AU - Rapoport, Judith L AD - Child Psychiatry Branch, National Instit Mental Health, Bethesda, MD shawp@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 1381 EP - 1386 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 45 IS - 11 SN - 0890-8567, 0890-8567 KW - Schizophrenia KW - Clinical decision making KW - Childhood KW - Child psychotherapy KW - Psychoses KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57088081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Decision+Making+about+Children+with+Psychotic+Symptoms%3A+Using+the+Best+Evidence+in+Choosing+a+Treatment&rft.au=Shaw%2C+Philip%3BRapoport%2C+Judith+L&rft.aulast=Shaw&rft.aufirst=Philip&rft.date=2006-11-01&rft.volume=45&rft.issue=11&rft.spage=1381&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2F01.chi.0000233780.53785.a4 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-02-06 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Clinical decision making; Psychoses; Child psychotherapy; Schizophrenia; Childhood DO - http://dx.doi.org/10.1097/01.chi.0000233780.53785.a4 ER - TY - JOUR T1 - NIH to Map Genomic Changes of 3 Cancers AN - 219249546; 17133706 AB - The National Cancer Institute (NCI) und the National Human Genome Research Institute (NHGRI), both part of the National Institutes of Health (NIH), announced on September 13 the first 3 cancers that will be studied in the pilot phase of The Cancer Genome Atlas TCGA* project: lung, brain (glioblastoma), and ovarian cancers. JF - The Journal of Nuclear Medicine AU - National Cancer Institute AU - National Human Genome Research Institute AD - National Cancer Institute ; National Human Genome Research Institute Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 22N EP - 27N CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Genomics KW - Medical research KW - Ovarian cancer KW - Pilot projects KW - Studies KW - Cancer KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Computational Biology -- methods KW - Chromosome Mapping KW - Male KW - Female KW - Genome, Human KW - Brain Neoplasms -- genetics KW - Ovarian Neoplasms -- genetics KW - Lung Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219249546?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIH+to+Map+Genomic+Changes+of+3+Cancers&rft.au=National+Cancer+Institute%3BNational+Human+Genome+Research+Institute&rft.aulast=National+Cancer+Institute&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=22N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - NIAID Awards $4 Million to Develop Anti-Radiation Treatments AN - 219184135; 17139786 AB - On September 25, the National Institute of Allergy and Infectious Diseases (NIAID), part of me National Institutes of Health (NIH), announced 5 awards totaling $4 million to fund the development of products that eliminate radioactive materials from the human body after radiologie or nuclear exposure. JF - The Journal of Nuclear Medicine AU - National Institute of Allergy and Infectious Diseases AD - National Institute of Allergy and Infectious Diseases Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1 CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Radioactive materials KW - Product development KW - Infectious diseases KW - Radiation KW - Allergies KW - Awards & honors KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Research -- trends KW - Radiation Injuries -- prevention & control KW - Research Support as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219184135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIAID+Awards+%244+Million+to+Develop+Anti-Radiation+Treatments&rft.au=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aulast=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - Cancer Death Rates Continue to Drop AN - 219181166; 17133705 AB - The report finds that for 1999 to 2003, Latinos had louer incidence rales than non-Hispanic whites (NHW) for most cancers, but were less likely than the NHW population to he diagnosed with localized stage disease for cancers of the lung, colon and rectum, prostate, female breast, and cervix. The report points to several important considerations in developing health inlerventions for Latinos, including: higher incidence of some infection-related cancers; elevated exposures to environmental risk factors in Latinos' living and work places; lower education, health literacy, and income; limited English proficiency; reduced use of screening services; limited access to health care, often because of lack of insurance; and less information available regarding possible genetic predisposition to cancer. JF - The Journal of Nuclear Medicine AU - National Institutes of Health AD - National Institutes of Health Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1 CY - New York PB - Society of Nuclear Medicine VL - 47 IS - 11 SN - 01615505 KW - Physics KW - Womens health KW - Breast cancer KW - Tropical diseases KW - Risk factors KW - United States KW - Registries KW - Ethnic Groups KW - Humans KW - Incidence KW - Male KW - Female KW - Neoplasms -- mortality KW - Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/219181166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=Cancer+Death+Rates+Continue+to+Drop&rft.au=National+Institutes+of+Health&rft.aulast=National+Institutes+of+Health&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright Society of Nuclear Medicine Nov 2006 N1 - Last updated - 2012-02-19 N1 - CODEN - JNMEAQ ER - TY - JOUR T1 - REporting recommendations for tumor MARKer prognostic studies (REMARK) AN - 212473553; 16932852 AB - Despite years of research and hundreds of reports on tumor markers in oncology, the number of markers that have emerged as clinically useful is pitifully small. Often initially reported studies of a marker show great promise, but subsequent studies on the same or related markers yield inconsistent conclusions or stand in direct contradiction to the promising results. It is imperative that we attempt to understand the reasons that multiple studies of the same marker lead to differing conclusions. A variety of methodologic problems have been cited to explain these discrepancies. Unfortunately, many tumor marker studies have not been reported in a rigorous fashion, and published articles often lack sufficient information to allow adequate assessment of the quality of the study or the generalizability of study results. The development of guidelines for the reporting of tumor marker studies was a major recommendation of the National Cancer Institute-European Organisation for Research and Treatment of Cancer (NCI-EORTC) First International Meeting on Cancer Diagnostics in 2000. As for the successful CONSORT initiative for randomized trials and for the STARD statement for diagnostic studies, we suggest guidelines to provide relevant information about the study design, pre-planned hypotheses, patient and specimen characteristics, assay methods, and statistical analysis methods. In addition, the guidelines suggest helpful presentations of data and important elements to include in discussions. The goal of these guidelines is to encourage transparent and complete reporting so that the relevant information will be available to others to help them to judge the usefulness of the data and understand the context in which the conclusions apply.[PUBLICATION ABSTRACT] JF - Breast Cancer Research and Treatment AU - Lisa M. McShaneDouglas G. AltmanWilli SauerbreiSheila E. TaubeMassimo GionGary M. Clark Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 229 EP - 35 CY - Dordrecht PB - Springer Science & Business Media VL - 100 IS - 2 SN - 01676806 KW - Medical Sciences--Oncology KW - Tumor Markers, Biological KW - Medical prognosis KW - Guidelines KW - Research methodology KW - Tumors KW - Humans KW - Prognosis KW - Guidelines as Topic KW - Research Design KW - Neoplasms -- diagnosis KW - Biomedical Research -- standards KW - Tumor Markers, Biological -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/212473553?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+environmental+monitoring+%3A+JEM&rft.atitle=Assessment+of+dermal+exposure+to+benzene+and+toluene+in+shoe+manufacturing+by+activated+carbon+cloth+patches.&rft.au=Vermeulen%2C+Roel%3BLan%2C+Qing%3BLi%2C+Guilan%3BRappaport%2C+Stephen+M%3BKim%2C+Sungkyoon%3Bvan+Wendel+de+Joode%2C+Berna%3BShen%2C+Min%3BBohong%2C+Xu%3BSmith%2C+Martyn+T%3BZhang%2C+Luoping%3BYin%2C+Songnian%3BRothman%2C+Nathaniel&rft.aulast=Vermeulen&rft.aufirst=Roel&rft.date=2006-11-01&rft.volume=8&rft.issue=11&rft.spage=1143&rft.isbn=&rft.btitle=&rft.title=Journal+of+environmental+monitoring+%3A+JEM&rft.issn=14640325&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, LLC 2006 N1 - Last updated - 2014-08-16 N1 - CODEN - BCTRD6 DO - http://dx.doi.org/10.1007/s10549-006-9242-8 ER - TY - JOUR T1 - An improved recombinant mammalian cell expression system for human transforming growth factor- beta 2 and - beta 3 preparations AN - 21035538; 8586352 AB - Transforming growth factor- beta 2 and - beta 3 (TGF- beta 2 and - beta 3) are important members of TGF- beta family which play important roles in the growth, maintenance, and repair processes of developing embryos, neonates, and adults. Preparation of large quantities of these two cytokines, which is necessary for structural studies and other applications, has proven to be extremely difficult. We have developed a novel Chinese hamster ovary cell-based expression system for high-level expression and high recovery of recombinant human TGF- beta 2 and - beta 3. In this system, we used a mammalian expression vector which contains a glutamine synthetase coding region for amplification, together with a modified TGF- beta 2 or - beta 3 open reading frame for expression. The leader peptide of TGF- beta 2 or - beta 3 was replaced by that from the V-J2-C region of a mouse immunoglobulin [kappa]-chain, and a poly-histidine tag was inserted immediately after the leader sequence to facilitate protein purification without changing the mature TGF- beta 2 or - beta 3 amino acid sequence. In addition, the extreme N-terminal cysteine residue of TGF- beta 2 or - beta 3 was replaced by a serine residue. The resulting expression constructs produced two stable cell clones expressing 10 mg of TGF- beta 2 and 8 mg of TGF- beta 3 per liter of spent medium. The purification scheme involved the use of two simple chromatographic steps with a typical yield of 5 mg of TGF- beta 2 and 4 mg of TGF- beta 3. This method represents a significant improvement over previously published methods and may be applicable to other TGF- beta superfamily members. We further confirmed that latent TGF- beta 2 and - beta 3 can be activated by proteolysis and glycolysis, which have not been reported before. JF - Protein Expression and Purification AU - Zou, Zhongcheng AU - Sun, Peter D AD - Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 12441 Parklawn Drive, Rockville, MD 20852, USA, psun@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 9 EP - 17 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Biotechnology and Bioengineering Abstracts KW - Proteolysis KW - protein purification KW - Protein sorting signals KW - Expression vectors KW - Glutamate-ammonia ligase KW - Mammalian cells KW - Cysteine KW - Cytokines KW - Transforming growth factor-^b KW - Embryos KW - Neonates KW - Glycolysis KW - Open reading frames KW - Serine KW - Amino acid sequence KW - Immunoglobulins KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21035538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=An+improved+recombinant+mammalian+cell+expression+system+for+human+transforming+growth+factor-+beta+2+and+-+beta+3+preparations&rft.au=Zou%2C+Zhongcheng%3BSun%2C+Peter+D&rft.aulast=Zou&rft.aufirst=Zhongcheng&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.06.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Transforming growth factor-^b; protein purification; Neonates; Glutamate-ammonia ligase; Serine; Protein sorting signals; Cytokines; Proteolysis; Embryos; Glycolysis; Cysteine; Expression vectors; Mammalian cells; Open reading frames; Immunoglobulins; Amino acid sequence DO - http://dx.doi.org/10.1016/j.pep.2006.06.022 ER - TY - JOUR T1 - Phase II trial of PN401, 5-FU, and leucovorin in unresectable or metastatic adenocarcinoma of the stomach: A Southwest Oncology Group study AN - 20864069; 7137474 AB - From February, 2001 to September, 2002, the Southwest Oncology Group (SWOG) accrued 65 patients with advanced gastric adenocarcinoma to a phase II trial of weekly 5-FU, leucovorin, and the orally-administered uridine analog PN401. Of these 65 patients, 57 were assessable for survival and toxicity, which were the endpoints for the study. Treatment consisted of the administration of 1200 mg/m super(2) of 5-FU, 500 mg/m super(2) of leucovorin, and 6 grams of PN401 every 8 h, beginning 8 h after the completion of the 5-FU infusion, and continuing for a total of 8 doses (48 grams) during each weekly chemotherapy session. Therapy was delivered for six weeks out of every 8-week treatment cycle. The gastrointestinal toxicity of this regimen was mild with 2 patients experiencing grade 3 stomatitis, and 6 patients having grade 3 diarrhea; and the hematologic toxicity was acceptable with 6 of 57 patients found to have had grade 3 or 4 leukopenia, and 14 of 57 patients experiencing grade 3 or 4 neutropenia. There were two deaths judged possibly related to treatment; one in a patient who experienced a variety of Grade 2 gastrointestinal toxicities and died at home with an unknown cause of death; and a second patient who also died at home, and for whom treatment-related sepsis could not be ruled out. The overall median survival was 7.2 months. The ability to safely deliver twice the usual dose of 5-FU with leucovorin on a weekly schedule suggests that oral uridine analog supplementation with PN401 may enhance the therapeutic index of the fluoropyrimidines. JF - Investigational New Drugs AU - Doroshow, James H AU - McCoy, Sheryl AU - Macdonald, John S AU - Issell, Brian F AU - Patel, Taral AU - Cobb, Patrick W AU - Yost, Kathleen J AU - Abbruzzese, James L AD - National Cancer Institute, City of Hope National Medical Center, Duarte, CA, doroshoj@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 537 EP - 542 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 24 IS - 6 SN - 0167-6997, 0167-6997 KW - Toxicology Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Diarrhea KW - Stomatitis KW - Chemotherapy KW - Survival KW - Oncology KW - Toxicity KW - Clinical trials KW - Supplementation KW - Metastases KW - Neutropenia KW - Sepsis KW - Uridine KW - Leukopenia KW - Adenocarcinoma KW - Stomach KW - X 24310:Pharmaceuticals KW - J 02400:Human Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20864069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Phase+II+trial+of+PN401%2C+5-FU%2C+and+leucovorin+in+unresectable+or+metastatic+adenocarcinoma+of+the+stomach%3A+A+Southwest+Oncology+Group+study&rft.au=Doroshow%2C+James+H%3BMcCoy%2C+Sheryl%3BMacdonald%2C+John+S%3BIssell%2C+Brian+F%3BPatel%2C+Taral%3BCobb%2C+Patrick+W%3BYost%2C+Kathleen+J%3BAbbruzzese%2C+James+L&rft.aulast=Doroshow&rft.aufirst=James&rft.date=2006-11-01&rft.volume=24&rft.issue=6&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-006-9244-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Diarrhea; Stomatitis; Chemotherapy; Survival; Oncology; Toxicity; Clinical trials; Supplementation; Metastases; Neutropenia; Sepsis; Uridine; Adenocarcinoma; Leukopenia; Stomach DO - http://dx.doi.org/10.1007/s10637-006-9244-8 ER - TY - JOUR T1 - T measurement during first-pass contrast-enhanced cardiac perfusion imaging AN - 20860543; 8368314 AB - First-pass contrast-enhanced (CE) myocardial perfusion imaging will experience T effects at peak concentrations of contrast agent. A reduction in the signal intensity of left ventricular (LV) blood due to T losses may effect estimates of the arterial input function (AIF) used for quantitative perfusion measurement. Imaging artifacts may also result from T losses as well as off-resonance due to the bolus susceptibility. We hypothesized that T losses would not be significant for measurement of the AIF in full-dose studies using a short echo time (TE = 0.6 ms). The purpose of this study was to directly measure T in the LV cavity during first-pass perfusion. For single-dose Gd-DTPA (0.1 mmol/kg at 5 ml/s), the LV blood pool T had a mean value of 9 ms (N = 10) at peak enhancement. Distortion of the AIF due to T signal intensity loss will be less than 10% using TE = 0.6 ms. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Kellman, Peter AU - Aletras, Anthony H AU - Hsu, Li-yueh AU - McVeigh, Elliot R AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung and Blood Institute, National Institutes of Health, DHHS, Bethesda, Maryland, USA, kellman@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1132 EP - 1134 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Cavities KW - Blood KW - Perfusion KW - Magnetic resonance imaging KW - Contrast media KW - Apoptosis-inducing factor KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20860543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=T+measurement+during+first-pass+contrast-enhanced+cardiac+perfusion+imaging&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-11-01&rft.volume=16&rft.issue=6&rft.spage=474&rft.isbn=&rft.btitle=&rft.title=Journal+of+Exposure+Science+and+Environmental+Epidemiology&rft.issn=15590631&rft_id=info:doi/10.1038%2Fsj.jes.7500531 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Perfusion; imaging; Apoptosis-inducing factor; Blood; Magnetic resonance imaging; Cavities; Contrast media; Heart DO - http://dx.doi.org/10.1002/mrm.21061 ER - TY - JOUR T1 - Real-time interactive MRI-guided cardiac surgery: Aortic valve replacement using a direct apical approach AN - 20855451; 8368293 AB - Minimally invasive cardiac surgery requires arresting and emptying of the heart, which compromises visualization of the surgical field. In this feasibility study a novel surgical procedure is demonstrated in which real-time MRI is used to guide the placement of a prosthetic aortic valve in the beating heart via direct apical access in eight porcine hearts. A clinical stentless bioprosthetic valve affixed to a platinum stent was compressed onto a balloon-tipped catheter. This was fed through a 15-18-mm delivery port inserted into the left ventricular (LV) apex via a minimally invasive subxyphoid incision. Using interactive real-time MRI, the surgeon implanted the prosthetic valve in the correct location at the aortic annulus within 90 s. In four of the animals immediately after implantation, ventricular function, blood flow through the valve, and myocardial perfusion were evaluated with MRI. MRI-guided beating-heart surgery may provide patients with a less morbid and more durable solution to structural heart disease. JF - Magnetic Resonance in Medicine AU - McVeigh, Elliot R AU - Guttman, Michael A AU - Lederman, Robert J AU - Li, Ming AU - Kocaturk, Ozgur AU - Hunt, Timothy AU - Kozlov, Shawn AU - Horvath, Keith A AD - Laboratory of Cardiac Energetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA, mcveigh@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 958 EP - 964 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 5 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Perfusion KW - Aortic valve KW - Aorta KW - Magnetic resonance imaging KW - prosthetic valves KW - Surgery KW - Platinum KW - Catheters KW - N.M.R. KW - Prosthetics KW - Heart diseases KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20855451?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+interactive+MRI-guided+cardiac+surgery%3A+Aortic+valve+replacement+using+a+direct+apical+approach&rft.au=McVeigh%2C+Elliot+R%3BGuttman%2C+Michael+A%3BLederman%2C+Robert+J%3BLi%2C+Ming%3BKocaturk%2C+Ozgur%3BHunt%2C+Timothy%3BKozlov%2C+Shawn%3BHorvath%2C+Keith+A&rft.aulast=McVeigh&rft.aufirst=Elliot&rft.date=2006-11-01&rft.volume=56&rft.issue=5&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Heart; Surgery; Magnetic resonance imaging; Aortic valve; Heart diseases; Prosthetics; N.M.R.; Aorta; Catheters; prosthetic valves; Platinum; Perfusion DO - http://dx.doi.org/10.1002/mrm.21044 ER - TY - JOUR T1 - Review of reported cholera outbreaks worldwide, 1995-2005 AN - 20753877; 7728299 AB - The global temporal and spatial distribution of cholera is underappreciated, given the lack of surveillance in endemic areas and economic disincentives to report outbreaks. To judge the use of specific novel interventions such as vaccines or anti-secretory agents, we compiled a database and analyzed cholera reports from the Program for Monitoring Emerging Diseases from 1995 to 2005. Of the 632 reports meeting the search criteria, 66% originated in Sub-Saharan Africa, followed by 16.8% from Southeast Asia. Reported outbreaks in Africa tended to be larger in size. The most common risk factors were water source contamination, heavy rainfall and flooding, and population dislocation. While cholera reporting is sub-optimal, this review provides a detailed sub-national quantification of cholera, identifies foci of endemicity in Africa, and describes risk factors by region. We highlight the need for more extensive outbreak reporting to justify investments in new interventions. JF - American Journal of Tropical Medicine and Hygiene AU - Griffith, D C AU - Kelly-Hope, LA AU - Miller, MA AD - Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, 16 Center Drive, Bethesda, MD 20892, USA, millermark@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 973 EP - 977 VL - 75 IS - 5 SN - 0002-9637, 0002-9637 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality KW - Environmental monitoring KW - Pollution monitoring KW - Spatial distribution KW - Contamination KW - Pathogenic bacteria KW - Rainfall KW - Bacterial diseases KW - Computer programs KW - Databases KW - Endemic species KW - Dislocation KW - Literature reviews KW - Reviews KW - Risk factors KW - Economics KW - Flooding KW - Africa KW - Cholera KW - Vaccines KW - Southeast Asia KW - Hygiene KW - J 02400:Human Diseases KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20753877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.atitle=Review+of+reported+cholera+outbreaks+worldwide%2C+1995-2005&rft.au=Griffith%2C+D+C%3BKelly-Hope%2C+LA%3BMiller%2C+MA&rft.aulast=Griffith&rft.aufirst=D&rft.date=2006-11-01&rft.volume=75&rft.issue=5&rft.spage=973&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Tropical+Medicine+and+Hygiene&rft.issn=00029637&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2014-05-07 N1 - SubjectsTermNotLitGenreText - Environmental monitoring; Pollution monitoring; Endemic species; Literature reviews; Pathogenic bacteria; Bacterial diseases; Flooding; Vaccines; Hygiene; Databases; Computer programs; Dislocation; Contamination; Spatial distribution; Rainfall; Risk factors; Reviews; Economics; Cholera; Africa; Southeast Asia ER - TY - JOUR T1 - Sustained high-titer antibody responses induced by conjugating a malarial vaccine candidate to outer-membrane protein complex AN - 20727619; 7194055 AB - The development of protein subunit vaccines to combat some of the world's deadliest pathogens such as a malaria parasite, Plasmodium falciparum, is stalled, due in part to the inability to induce and sustain high-titer antibody responses. Here, we show the induction of persistent, high-titer antibody responses to recombinant Pfs25H, a human malarial transmission-blocking protein vaccine candidate, after chemical conjugation to the outer-membrane protein complex (OMPC) of Neisseria meningitidis serogroup B and adsorption to aluminum hydroxyphosphate. In mice, the Pfs25H-OMPC conjugate vaccine was >1,000 times more potent in generating anti-Pfs25H ELISA reactivity than a similar 0.5- mu g dose of Pfs25H alone in Montanide ISA720, a water-in-oil adjuvant. The immune enhancement requires covalent conjugation between Pfs25H and the OMPC, given that physically mixed Pfs25H and OMPC on aluminum hydroxyphosphate failed to induce greater activity than the nonconjugated Pfs25H on aluminum hydroxyphosphate. The conjugate vaccine Pfs25H-OMPC also was highly immunogenic in rabbits and rhesus monkeys. In rhesus monkeys, the antibody responses were sustained over 18 months, at which time another vaccination with nonconjugated Pfs25H induced strong anamnestic responses. The vaccine-induced anti-Pfs25-specific antibodies in all animal species blocked the transmission of parasites to mosquitoes. Protein antigen conjugation to OMPC or other protein carrier may have general application to a spectrum of protein subunit vaccines to increase immunogenicity without the need for potentially reactogenic adjuvants. JF - Proceedings of the National Academy of Sciences, USA AU - Wu, Yimin AU - Przysiecki, Craig AU - Flanagan, Elizabeth AU - Bello-Irizarry, Sheila N AU - Ionescu, Roxana AU - Muratova, Olga AU - Dobrescu, Gelu AU - Lambert, Lynn AU - Keister, David AU - Rippeon, Yvette AU - Long, Carole A AU - Shi, Li AU - Caulfield, Michael AU - Shaw, Alan AU - Saul, Allan AU - Shiver, John AU - Miller, Louis H AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852 Y1 - 2006/11// PY - 2006 DA - November 2006 SP - 18243 EP - 18248 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 48 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; ASFA 3: Aquatic Pollution & Environmental Quality; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Enzyme-linked immunosorbent assay KW - Conjugation KW - Disease control KW - Malaria KW - Neisseria meningitidis KW - Plasmodium falciparum KW - Adjuvants KW - Pathogens KW - Antibodies KW - Antigens KW - Immunogenicity KW - Aluminum KW - Aluminium KW - Adsorption KW - ELISA KW - Macaca mulatta KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20727619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Sustained+high-titer+antibody+responses+induced+by+conjugating+a+malarial+vaccine+candidate+to+outer-membrane+protein+complex&rft.au=Wu%2C+Yimin%3BPrzysiecki%2C+Craig%3BFlanagan%2C+Elizabeth%3BBello-Irizarry%2C+Sheila+N%3BIonescu%2C+Roxana%3BMuratova%2C+Olga%3BDobrescu%2C+Gelu%3BLambert%2C+Lynn%3BKeister%2C+David%3BRippeon%2C+Yvette%3BLong%2C+Carole+A%3BShi%2C+Li%3BCaulfield%2C+Michael%3BShaw%2C+Alan%3BSaul%2C+Allan%3BShiver%2C+John%3BMiller%2C+Louis+H&rft.aulast=Wu&rft.aufirst=Yimin&rft.date=2006-11-01&rft.volume=103&rft.issue=48&rft.spage=18243&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Parasites; Conjugation; Antibodies; Antigens; Aluminium; Disease control; ELISA; Pathogens; Vaccines; Enzyme-linked immunosorbent assay; Immunogenicity; Aluminum; Adsorption; Malaria; Adjuvants; Macaca mulatta; Plasmodium falciparum; Neisseria meningitidis ER - TY - JOUR T1 - The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria AN - 20724558; 7120598 AB - Toxin-antitoxin systems (TAS) are abundant, diverse, horizontally mobile gene modules that encode powerful resistance mechanisms in prokaryotes. We use the comparative-genomic approach to predict a new TAS that consists of a two-gene cassette encoding uncharacterized HicA and HicB proteins. Numerous bacterial and archaeal genomes encode from one to eight HicAB modules which appear to be highly prone to horizontal gene transfer. The HicB protein (COG1598/COG4226) has a partially degraded RNAse H fold, whereas HicA (COG1724) contains a double-stranded RNA-binding domain. The stable combination of these two domains suggests a link to RNA metabolism, possibly, via an RNA interference-type mechanism. In most HicB proteins, the RNAse H-like domain is fused to a DNA-binding domain, either of the ribbon-helix-helix or of the helix-turn-helix class; in other TAS, proteins containing these DNA-binding domains function as antitoxins. Thus, the HicAB module is predicted to be a novel TAS whose mechanism involves RNA-binding and, possibly, cleavage. Supplementary information: Supplementary data are available at Bioinformatics online. JF - Bioinformatics AU - Makarova, Kira S AU - Grishin, Nick V AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health Bethesda, MD 20894, USA. Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas 5323 Harry Hines Boulevard, Dallas, TX 75390-9050, USA, koonin@ncbi.nlm.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 2581 EP - 2584 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 21 SN - 1367-4803, 1367-4803 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Antitoxins KW - Data processing KW - Archaea KW - ribonuclease A KW - RNA KW - Gene transfer KW - Ribonuclease H KW - ribonuclease H KW - Ribonuclease KW - Bioinformatics KW - Prokaryotes KW - Metabolism KW - A 01490:Miscellaneous KW - J 02330:Biochemistry KW - X 24490:Other KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724558?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=The+HicAB+cassette%2C+a+putative+novel%2C+RNA-targeting+toxin-antitoxin+system+in+archaea+and+bacteria&rft.au=Makarova%2C+Kira+S%3BGrishin%2C+Nick+V%3BKoonin%2C+Eugene+V&rft.aulast=Makarova&rft.aufirst=Kira&rft.date=2006-11-01&rft.volume=22&rft.issue=21&rft.spage=2581&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Antitoxins; Genomes; ribonuclease A; Data processing; RNA; Gene transfer; Ribonuclease H; ribonuclease H; Ribonuclease; Prokaryotes; Bioinformatics; Metabolism; Archaea ER - TY - JOUR T1 - A Comparison of the Emission Efficiency of Four Common Green Fluorescence Dyes after Internalization into Cancer Cells AN - 20358055; 7598594 AB - In vivo optical imaging to enhance the detection of cancer during endoscopy or surgery requires a targeted fluorescent probe with high emission efficiency and high signal-to-background ratio. One strategy to accurately detect cancers is to have the fluorophore internalize within the cancer cells permitting nonbound fluorophores to be washed away or absorbed. The choice of fluorophores for this task must be carefully considered. For depth of penetration, near-infrared probes are ordinarily preferred but suffer from relatively low quantum efficiency. Although green fluorescent protein has been widely used to image tumors on internal organs in mice, green fluorescent probes are better suited for imaging the superficial tissues because of the short penetration distance of green light in tissue and the highly efficient production of signal. While the fluorescence properties of green fluorophores are well-known in vitro, less attention has been paid to their fluorescence once they are internalized within cells. In this study, the emission efficiency after cellular internalization of four common green fluorophores conjugated to avidin (Av-fluorescein, Av-Oregon green, Av-BODIPY-FL, and Av-rhodamine green) were compared after each conjugate was incubated with SHIN3 ovarian cancer cells. Using the lectin binding receptor system, the avidin-fluorophore conjugates were endocytosed, and their fluorescence was evaluated with fluorescence microscopy and flow cytometry. While fluorescein demonstrated the highest signal outside the cell, among the four fluorophores, internalized Av-rhodamine green emitted the most light from SHIN3 ovarian cancer cells both in vitro and in vivo. The internalized Av-rhodamine green complex appeared to localize to the endoplasmic vesicles. Thus, among the four common green fluorescent dyes, rhodamine green is the brightest green fluorescence probe after cellular internalization. This information could have implications for the design of tumor-targeted fluorescent probes that rely on cellular internalization for cancer detection. JF - Bioconjugate Chemistry AU - Hama, Y AU - Urano, Y AU - Koyama, Y AU - Bernardo, M AU - Choyke, P L AU - Kobayashi, H AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1088, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1426 EP - 1431 VL - 17 IS - 6 SN - 1043-1802, 1043-1802 KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Green fluorescent protein KW - Probes KW - Lectins KW - Tumors KW - fluorophores KW - imaging KW - Light effects KW - Endoscopy KW - fluorescein KW - Flow cytometry KW - Avidin KW - Dyes KW - Surgery KW - Fluorescent indicators KW - Vesicles KW - rhodamine KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20358055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioconjugate+Chemistry&rft.atitle=A+Comparison+of+the+Emission+Efficiency+of+Four+Common+Green+Fluorescence+Dyes+after+Internalization+into+Cancer+Cells&rft.au=Hama%2C+Y%3BUrano%2C+Y%3BKoyama%2C+Y%3BBernardo%2C+M%3BChoyke%2C+P+L%3BKobayashi%2C+H&rft.aulast=Hama&rft.aufirst=Y&rft.date=2006-11-01&rft.volume=17&rft.issue=6&rft.spage=1426&rft.isbn=&rft.btitle=&rft.title=Bioconjugate+Chemistry&rft.issn=10431802&rft_id=info:doi/10.1021%2Fbc0601626 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-10-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Probes; Green fluorescent protein; Lectins; fluorophores; Tumors; imaging; fluorescein; Endoscopy; Light effects; Flow cytometry; Avidin; Dyes; Surgery; Fluorescent indicators; Vesicles; rhodamine DO - http://dx.doi.org/10.1021/bc0601626 ER - TY - JOUR T1 - Molecular Analysis of Base Damage Clustering Associated with a Site-Specific Radiation-Induced DNA Double-Strand Break AN - 20277584; 7235230 AB - Base damage flanking a radiation-induced DNA double-strand break (DSB) may contribute to DSB complexity and affect break repair. However, to date, an isolated radiation-induced DSB has not been assessed for such structures at the molecular level. In this study, an authentic site-specific radiation-induced DSB was produced in plasmid DNA by triplex forming oligonucleotide-targeted super(125)I decay. A restriction fragment terminated by the DSB was isolated and probed for base damage with the E. coli DNA repair enzymes endonuclease III and formamidopyrimidine-DNA glycosylase. Our results demonstrate base damage clustering within 8 bases of the super(125)I-targeted base in the DNA duplex. An increased yield of base damage (purine > pyrimidine) was observed for DSBs formed by irradiation in the absence of DMSO. An internal control fragment 1354 bp upstream from the targeted base was insensitive to enzymatic probing, indicating that the damage detected proximal to the DSB was produced by the super(125)I decay that formed the DSB. Gas chromatography-mass spectrometry identified three types of damaged bases in the similar to 32-bp region proximal to the DSB. These base lesions were 8-hydroxyguanine, 8-hydroxyadenine and 5-hydroxycytosine. Finally, evidence is presented for base damage >24 bp upstream from the super(125)I-decay site that may form via a charge migration mechanism. JF - Radiation Research AU - Datta, K AU - Jaruga, P AU - Dizdaroglu, M AU - Neumann, R D AU - Winters, T A AD - Department of Nuclear Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 767 EP - 781 PB - Allen Press, Inc., 810 East Tenth St. Lawrence KS 66044 USA, [mailto:webmaster@allenpress.com], [URL:http://www.allenpress.com] VL - 166 IS - 5 SN - 0033-7587, 0033-7587 KW - Biochemistry Abstracts 2: Nucleic Acids; Toxicology Abstracts KW - Enzymes KW - Double-strand break repair KW - DNA repair KW - Plasmids KW - Migration KW - Mass spectroscopy KW - purines KW - DNA damage KW - 8-Hydroxyguanine KW - Gas chromatography KW - Escherichia coli KW - pyrimidines KW - formamidopyrimidine-DNA glycosylase KW - Endonuclease KW - X 24390:Radioactive Materials KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20277584?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=Molecular+Analysis+of+Base+Damage+Clustering+Associated+with+a+Site-Specific+Radiation-Induced+DNA+Double-Strand+Break&rft.au=Datta%2C+K%3BJaruga%2C+P%3BDizdaroglu%2C+M%3BNeumann%2C+R+D%3BWinters%2C+T+A&rft.aulast=Datta&rft.aufirst=K&rft.date=2006-11-01&rft.volume=166&rft.issue=5&rft.spage=767&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR0628.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=166&issue=5&page=767 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Enzymes; Plasmids; DNA repair; Double-strand break repair; Migration; purines; Mass spectroscopy; DNA damage; 8-Hydroxyguanine; Gas chromatography; formamidopyrimidine-DNA glycosylase; pyrimidines; Endonuclease; Escherichia coli DO - http://dx.doi.org/10.1667/RR0628.1 ER - TY - JOUR T1 - Functional Compensation for Adipose Differentiation-related Protein (ADFP) by Tip47 in an ADFP Null Embryonic Cell Line AN - 20240809; 7166416 AB - Ectopic accumulation of lipid droplets in non-adipose tissues correlates with the degree of insulin resistance in these tissues. Emerging evidence indicates that lipid droplets are specialized organelles that participate in lipid metabolism and intracellular trafficking. These properties are thought to derive from the lipid droplet-associated PAT protein family (perilipin, ADFP, and Tip47). The functions of the ubiquitously distributed adipose differentiation-related protein (ADFP) and Tip47 remain unknown. To evaluate the roles of ADFP and Tip47 in lipid biogenesis and metabolism, ADFP null and wild type (wt) clonal cell lines were established from ADFP null and wt mice, respectively. In ADFP null cells, Tip47 was identified as the sole lipid droplet-associated protein from the PAT family by mass spectroscopy, which was further confirmed by immunoblotting and immunocytochemistry. Following incubation with oleic acid, ADFP null cells were able to form lipid droplets to the same extent as wt cells. No statistical differences between the two cell types were observed in NEFA uptake or lipolysis. Small interference RNAs (siRNAs) against Tip47 were found to down-regulate protein levels for Tip47 by 85%. ADFP null cells treated with Tip47 siRNA retained the ability to form lipid droplets but to a lesser extent and shunted the utilization of exogenously added NEFA from triglycerides to phospholipids. These data support the hypothesis that Tip47 plays an important role in lipid metabolism. Tip47 and ADFP in peripheral tissues may play a critical role in regulating the formation and turnover, and hence metabolic consequences, of ectopic fat. JF - Journal of Biological Chemistry AU - Sztalryd, Carole AU - Bell, Ming AU - Lu, Xinyue AU - Mertz, Pamela AU - Hickenbottom, Sabrina AU - Chang, Benny H-J AU - Chan, Lawrence AU - Kimmel, Alan R AU - Londos, Constantine AD - Geriatric Research, Education and Clinical Center, Baltimore Veterans Affairs Health Care Center, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 21201, the Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892-8028, and the Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas 77030 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 34341 EP - 34348 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 45 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Immunoblotting KW - Immunocytochemistry KW - Data processing KW - Statistics KW - Null cells KW - protein families KW - Insulin KW - Lipid metabolism KW - siRNA KW - Triglycerides KW - Embryos KW - Lipolysis KW - Organelles KW - Oleic acid KW - Phospholipids KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20240809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Anti-HIV-1+immunotoxin+3B3%28Fv%29-PE38%3A+Enhanced+potency+against+clinical+isolates+in+human+PBMCs+and+macrophages%2C+and+negligible+hepatotoxicity+in+macaques&rft.au=Kennedy%2C+P+E%3BBera%2C+T+K%3BWang%2C+Q-C%3BGallo%2C+M%3BWagner%2C+W%3BLewis%2C+M+G%3BBerger%2C+E+A%3BPastan%2C+I&rft.aulast=Kennedy&rft.aufirst=P&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Immunocytochemistry; Immunoblotting; Statistics; Data processing; Null cells; protein families; Insulin; Lipid metabolism; siRNA; Triglycerides; Embryos; Lipolysis; Organelles; Oleic acid; Phospholipids ER - TY - JOUR T1 - Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis AN - 20235975; 7166862 AB - Prior studies indicated the ability of Abs to complement receptor 3 (CR3, CD11b/CD18) to suppress the production of IL-12 from immune cells. Therefore, we tested the ability of an anti-CR3 Ab (clone M1/70) to treat established IL-12-dependent Th1-mediated inflammation in murine models. Systemic administration of anti-CR3 significantly ameliorated established intestinal inflammation following the intrarectal administration of trinitrobenzene sulfonic acid (TNBS-colitis), as well as colitis and skin inflammation in C57BL/10 RAG-2 super(-/-) mice reconstituted with CD4 super(+)CD45RB super(high) T cells. The hyperproliferative skin inflammation in this novel murine model demonstrated many characteristics of human psoriasis, and was prevented by the adoptive transfer of CD45RB super(low) T cells. In vitro and in vivo studies suggest that anti-CR3 treatment may act, at least in part, by directly inhibiting IL-12 production by APCs. Administration of anti-CR3 may be a useful therapeutic approach to consider for the treatment of inflammatory bowel disease and psoriasis in humans. JF - Journal of Immunology AU - Leon, Francisco AU - Contractor, Nikhat AU - Fuss, Ivan AU - Marth, Thomas AU - Lahey, Edward AU - Iwaki, Shoko AU - la Sala, Andrea AU - Hoffmann, Victoria AU - Strober, Warren AU - Kelsall, Brian L AD - Laboratory of Molecular Immunology, Laboratory of Host Defense, and Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Office of Research Services, Division of Veterinary Resources, Office of the Director, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6974 EP - 6982 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - Skin KW - sulfonic acid KW - Animal models KW - CD18 antigen KW - Interleukin 12 KW - Antibodies KW - Inflammatory bowel diseases KW - Psoriasis KW - CD11b antigen KW - Adoptive transfer KW - Lymphocytes T KW - Intestine KW - complement receptor 3 KW - Antigen-presenting cells KW - Colitis KW - Dermatitis KW - W 30940:Products KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20235975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Antibodies+to+Complement+Receptor+3+Treat+Established+Inflammation+in+Murine+Models+of+Colitis+and+a+Novel+Model+of+Psoriasiform+Dermatitis&rft.au=Leon%2C+Francisco%3BContractor%2C+Nikhat%3BFuss%2C+Ivan%3BMarth%2C+Thomas%3BLahey%2C+Edward%3BIwaki%2C+Shoko%3Bla+Sala%2C+Andrea%3BHoffmann%2C+Victoria%3BStrober%2C+Warren%3BKelsall%2C+Brian+L&rft.aulast=Leon&rft.aufirst=Francisco&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=6974&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Skin; Animal models; sulfonic acid; CD18 antigen; Interleukin 12; Antibodies; Inflammatory bowel diseases; Psoriasis; CD11b antigen; Intestine; Lymphocytes T; Adoptive transfer; complement receptor 3; Antigen-presenting cells; Colitis; Dermatitis ER - TY - JOUR T1 - Prevention of cadmium induced lipid peroxidation, depletion of some antioxidative enzymes and glutathione by a series of novel organoselenocyanates AN - 20234574; 7079049 AB - A series of organoselenocyanate compounds 4a-d were synthesized utilizing 1,8-naphthalic anhydride as the building unit. To evaluate the preventive potential of the Se compounds against Cd induced hepatic lipid peroxidation and oxidative stress, female Swiss Albino mice were exposed to Cd (as CdCl sub(2)) during 20 days at a dose of 1 or 2 mg/kg bw given ip and the selenium compounds were given at the dose of 3 mg/kg bw orally in a pretreatment and concomitant treatment schedule. Hepatic lipid peroxidation level was increased significantly by Cd, whereas the glutathione-S-transferase (GST), superoxide dismutase(SOD), reduced glutathione(GSH) and catalase(CAT) levels were decreased. The selenium compounds effectively decreased the hepatic lipid peroxidation level of the animals treated with Cd. The compounds were also effective in restoring the GST, SOD, and GSH as well as CAT level towards normal. Cadmium induced enhanced Serum alanine aminotransferase (ALT) and aspertate aminotransferase (AST) le JF - Environmental Toxicology and Pharmacology AU - Sk, Ugir Hossain AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata-700 026, West Bengal, India, sudinb19572004@yahoo.co.in Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 298 EP - 308 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 22 IS - 3 SN - 1382-6689, 1382-6689 KW - Toxicology Abstracts; Biotechnology and Bioengineering Abstracts KW - Organoselenocyanates KW - Lipid peroxidation KW - Cadmium KW - Liver KW - Mice KW - Selenium compounds KW - Oxidative stress KW - Superoxide dismutase KW - Glutathione KW - Enzymes KW - Glutathione transferase KW - Alanine transaminase KW - W 30940:Products KW - X 24360:Metals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20234574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Toxicology+and+Pharmacology&rft.atitle=Prevention+of+cadmium+induced+lipid+peroxidation%2C+depletion+of+some+antioxidative+enzymes+and+glutathione+by+a+series+of+novel+organoselenocyanates&rft.au=Sk%2C+Ugir+Hossain%3BBhattacharya%2C+Sudin&rft.aulast=Sk&rft.aufirst=Ugir&rft.date=2006-11-01&rft.volume=22&rft.issue=3&rft.spage=298&rft.isbn=&rft.btitle=&rft.title=Environmental+Toxicology+and+Pharmacology&rft.issn=13826689&rft_id=info:doi/10.1016%2Fj.etap.2006.04.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Selenium compounds; Glutathione; Superoxide dismutase; Oxidative stress; Liver; Enzymes; Cadmium; Alanine transaminase; Glutathione transferase; Lipid peroxidation DO - http://dx.doi.org/10.1016/j.etap.2006.04.004 ER - TY - JOUR T1 - The RNase a superfamily: Generation of diversity and innate host defense AN - 20201639; 7309920 AB - The Ribonuclease A superfamily includes an extensive network of distinct and divergent gene lineages. Although all ribonu cleases of this superfamily share invariant structural and catalytic elements and some degree of enzymatic activity, the primary sequences have diverged significantly, ostensibly to promote novel function. We will review the literature on the evolution and biology of the RNase A ribonuclease lineages that have been characterized specifically as involved in host defense including: (1) RNases 2 and RNases 3, also known as the eosinophil ribonucleases, which are rapidly-evolving cationic proteins released from eosinophilic leukocytes, (2) RNase 7, an anti-pathogen ribonuclease identified in human skin, and (3) RNase 5, also known as angiogenin, another rapidly-evolving ribonuclease known to promote blood vessel growth with recently-discovered antibacterial activity. Interestingly, some of the characterized anti-pathogen activities do not depend on ribonuclease activity per se. We discuss the ways in which the anti-pathogen activities characterized in vitro might translate into experimental confirmation in vivo. We will also consider the possibility that other ribonucleases, such as the dimeric bovine seminal ribonuclease and the frog oocyte ribonucleases, may have host defense functions and therapeutic value that remain to be explored. JF - Molecular Diversity AU - Dyer, K D AU - Rosenberg, H F AD - Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA, hrosenberg@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 585 EP - 597 VL - 10 IS - 4 SN - 1381-1991, 1381-1991 KW - Frogs KW - Toads KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Skin KW - Antibacterial activity KW - Anura KW - Leukocytes (eosinophilic) KW - ribonuclease 7 KW - ribonuclease A KW - Angiogenin KW - Blood vessels KW - Reviews KW - Oocytes KW - Ribonuclease KW - Enzymatic activity KW - Offense KW - Evolution KW - N 14835:Protein-Nucleic Acids Association KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20201639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Diversity&rft.atitle=The+RNase+a+superfamily%3A+Generation+of+diversity+and+innate+host+defense&rft.au=Dyer%2C+K+D%3BRosenberg%2C+H+F&rft.aulast=Dyer&rft.aufirst=K&rft.date=2006-11-01&rft.volume=10&rft.issue=4&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=Molecular+Diversity&rft.issn=13811991&rft_id=info:doi/10.1007%2Fs11030-006-9028-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - SuppNotes - Special Issue: Molecular Diversity of Proteins in Biological offense and Defense Systems. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Skin; Antibacterial activity; Leukocytes (eosinophilic); ribonuclease 7; ribonuclease A; Angiogenin; Blood vessels; Reviews; Ribonuclease; Oocytes; Enzymatic activity; Offense; Evolution; Anura DO - http://dx.doi.org/10.1007/s11030-006-9028-2 ER - TY - JOUR T1 - Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclide AN - 20098459; 7148286 AB - Exposure of cells to ionizing radiation (IR) produces changes in the expression level of a large number of genes. However, less is known of gene-expression changes caused by local radiation exposure from radionuclides within cells. We studied changes in the genome-wide gene expression induced by decay of super(1) super(2) super(5)I incorporated into DNA as [ super(1) super(2) super(5)I]-iododeoxyuridine ( super(1) super(2) super(5)I-IUdR) in normal IMR-90 human lung fibroblasts and compared them with the changes produced by external gamma -radiation delivered at high (HDR) or low (LDR) dose rate. We found that more than 2000 genes were consistently up- or down-regulated following HDR and LDR gamma -radiation. The profiles of differentially expressed genes following HDR and LDR shared about 64% (up) and 74% (down) genes in common, with many genes identified as radiation-responsive for the first time. In contrast, in all only 206 genes changed their expression level in the super(1) super(2) super(5)I-IUdR-treated cells, even though the total number of DNA double-strand breaks (DSB) produced by super(1) super(2) super(5)I-IUdR exceeded that produced by the gamma -radiation. With few exceptions, the expression levels of super(1) super(2) super(5)I-IUdR-responsive genes were also altered following gamma -irradiation. Therefore, nuclear DNA-localized decays of super(1) super(2) super(5)I produce 10 times fewer differentially expressed genes than whole-cell exposure to gamma -radiation of comparable dose. These results suggest that the effect of IR on the changes in global gene expression depends on the distribution of energy depositions within the cell. In contrast to cell survival, DNA DSB may not be the major factor modulating changes in gene expression following irradiation. JF - Gene AU - Sokolov, M V AU - Smirnova, NA AU - Camerini-Otero, R D AU - Neumann, R D AU - Panyutin, I G AD - Clinical Center, NIH, Bldg. 10 Room 4D45, 9000 Rockville Pike, Bethesda, MD 20892, United States, igorp@helix.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 47 EP - 56 PB - Elsevier B.V. VL - 382 SN - 0378-1119, 0378-1119 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts KW - Cell survival KW - Gene expression KW - DNA damage KW - Lung KW - Ionizing radiation KW - Energy KW - Radioisotopes KW - DNA KW - Fibroblasts KW - G 07710:Chemical Mutagenesis & Radiation KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20098459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Microarray+analysis+of+differentially+expressed+genes+after+exposure+of+normal+human+fibroblasts+to+ionizing+radiation+from+an+external+source+and+from+DNA-incorporated+iodine-125+radionuclide&rft.au=Sokolov%2C+M+V%3BSmirnova%2C+NA%3BCamerini-Otero%2C+R+D%3BNeumann%2C+R+D%3BPanyutin%2C+I+G&rft.aulast=Sokolov&rft.aufirst=M&rft.date=2006-11-01&rft.volume=382&rft.issue=&rft.spage=47&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2006.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Cell survival; DNA damage; Lung; Energy; Ionizing radiation; DNA; Radioisotopes; Fibroblasts DO - http://dx.doi.org/10.1016/j.gene.2006.06.008 ER - TY - JOUR T1 - The Minimal Instrumentation Requirements for Hoechst Side Population Analysis: Stem Cell Analysis on Low-Cost Flow Cytometry Platforms AN - 20010991; 7126889 AB - The Hoechst side population (SP) technique is a critical method of identifying stem cells and early progenitors in rodent, nonhuman primate, and human hematopoietic and nonhematopoietic tissues. In this technique, the cell-permeable DNA-binding dye Hoechst 33342 is loaded into the cell population of interest; stem cells and early progenitors subsequently pump this dye out via an ATP-binding cassette membrane pump-dependent mechanism, resulting in a low-fluorescence "tail" (the SP) when the cells are analyzed by flow cytometry. This population contains stem cells and early progenitors. One significant drawback of this method is the requirement of an UV laser to excite the Hoechst 33342. Unfortunately, flow cytometers equipped with UV sources are expensive to own and operate and are not readily available to many laboratories or institutions. In the interests of designing a less expensive flow cytometric system for stem cell analysis, we determined the minimum UV excitation and instrumentation requirements for measuring Hoechst SP. Less than 3 mW of UV laser output was required for adequate resolution of Hoechst SP on two cuvette-based flow cytometers, one of which was a simple, inexpensive benchtop analyzer (the Quanta Analyzer; NPE Systems). Furthermore, Hoechst SP could also be adequately resolved on this epifluorescence-based cytometer platform using two nonlaser UV sources, a mercury arc lamp with a UV bandpass filter and a UV-emitting light-emitting diode. These results suggest that an economical flow cytometric system can be designed that is capable of resolving Hoechst SP, with a cost far lower than most UV laser-equipped commercial systems. An inexpensive system of this type would make Hoechst SP analysis available to a much broader group of stem cell investigators. JF - Stem Cells AU - Cabana, Raquel AU - Frolova, Ella G AU - Kapoor, Veena AU - Thomas, Richard A AU - Krishan, Awtar AU - Telford, William G AD - NPE Systems, Pembroke Pines, Florida, USA. Metabolism Branch, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute-NIH, Bethesda, Maryland, USA. University of Miami School of Medicine, Miami, Florida, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2573 EP - 2581 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Flow cytometry KW - Filters KW - Stem cells KW - Tails KW - Hemopoiesis KW - Mercury KW - Lasers KW - Primates KW - Substance P KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20010991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Minimal+Instrumentation+Requirements+for+Hoechst+Side+Population+Analysis%3A+Stem+Cell+Analysis+on+Low-Cost+Flow+Cytometry+Platforms&rft.au=Cabana%2C+Raquel%3BFrolova%2C+Ella+G%3BKapoor%2C+Veena%3BThomas%2C+Richard+A%3BKrishan%2C+Awtar%3BTelford%2C+William+G&rft.aulast=Cabana&rft.aufirst=Raquel&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=2573&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Filters; Flow cytometry; Stem cells; Tails; Mercury; Hemopoiesis; Lasers; Substance P; Primates ER - TY - JOUR T1 - Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: Enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques AN - 20000842; 7307083 AB - Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically suppresses viral load, leading to marked reductions in HIV-1 associated morbidity and mortality. However, infected cell reservoirs and low-level replication persist in the face of suppressive HAART, leading invariably to viral rebound upon cessation of treatment. Toxins engineered to target the Env glycoprotein on the surface of productively infected cells represent a complementary strategy to deplete these reservoirs. We described previously highly selective killing of Env-expressing cell lines by CD4(178)-PE40 and 3B3(Fv)-PE38, recombinant derivatives of Pseudomonas aeruginosa exotoxin A containing distinct targeting moieties against gp120. In the present report, we compare the in vitro potency and breadth of these chimeric toxins against multiple clinical HIV-1 isolates, replicating in biologically relevant primary human target cell types. In PBMCs, 3B3(Fv)-PE38 blocked spreading infection by all isolates examined, with greater potency than CD4(178)-PE40. 3B3(Fv)-PE38 also potently inhibited spreading HIV-1 infection in primary macrophages. Control experiments demonstrated that in both target cell types, most of the 3B3(Fv)-PE38 activity was due to selective killing of infected cells, and not merely to neutralization by the antibody moiety of the chimeric toxin. High-dose treatment of rhesus macaques with 3B3(Fv)-PE38 did not induce liver toxicity, whereas equivalent dosage of CD4(178)-PE40 induced mild hepatotoxicity. These findings highlight the potential use of 3B3 (Fv)-PE38 for depleting HIV-infected cell reservoirs persisting in the face of HAART. JF - Journal of Leukocyte Biology AU - Kennedy, P E AU - Bera, T K AU - Wang, Q-C AU - Gallo, M AU - Wagner, W AU - Lewis, M G AU - Berger, E A AU - Pastan, I AD - Laboratory of Viral Diseases, NIAID National Institutes of Health Building 4, Room 237 Bethesda, MD 20892, USA, edward_berger@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1175 EP - 1182 VL - 80 IS - 5 SN - 0741-5400, 0741-5400 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Clinical isolates KW - Macrophages KW - Mortality KW - Spreading KW - Replication KW - Leukocytes KW - Toxicity KW - Infection KW - exotoxin A KW - Morbidity KW - Immunotoxins KW - hepatotoxicity KW - Toxins KW - Glycoprotein gp120 KW - Antibodies KW - highly active antiretroviral therapy KW - Human immunodeficiency virus 1 KW - Liver KW - Macaca mulatta KW - Pseudomonas aeruginosa KW - V 22360:AIDS and HIV KW - J 02330:Biochemistry KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20000842?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Anti-HIV-1+immunotoxin+3B3%28Fv%29-PE38%3A+Enhanced+potency+against+clinical+isolates+in+human+PBMCs+and+macrophages%2C+and+negligible+hepatotoxicity+in+macaques&rft.au=Kennedy%2C+P+E%3BBera%2C+T+K%3BWang%2C+Q-C%3BGallo%2C+M%3BWagner%2C+W%3BLewis%2C+M+G%3BBerger%2C+E+A%3BPastan%2C+I&rft.aulast=Kennedy&rft.aufirst=P&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1175&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306139 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Macrophages; Clinical isolates; Mortality; Spreading; Replication; Leukocytes; Toxicity; Infection; exotoxin A; Toxins; hepatotoxicity; Immunotoxins; Morbidity; Glycoprotein gp120; Antibodies; highly active antiretroviral therapy; Liver; Human immunodeficiency virus 1; Macaca mulatta; Pseudomonas aeruginosa DO - http://dx.doi.org/10.1189/jlb.0306139 ER - TY - JOUR T1 - Mycobacterium avium-induced SOCS contributes to resistance to IFN- gamma -mediated mycobactericidal activity in human macrophages AN - 19973613; 7307079 AB - Mycobacterium avium is an opportunistic pathogen that commonly infects individuals colonized with HIV-1, although it is less frequent in the post-HAART era. These microorganisms invade macrophages after interacting with TLR2 and/or CD14 co-receptors, but signaling pathways promoting survival in macrophages are not well defined. Although IFN- gamma plays an important role in protective immunity against bacterial infections, IFN- gamma responses are compromised in AIDS patients and evidence suggests that exogenous IFN- gamma is inadequate to clear the mycobacteria. To determine the mechanism by which M. avium survives intracellularly, even in the presence of IFN- gamma , we studied the effect of mycobacteria infection in macrophages during early IFN- gamma signaling events. M. avium infected cells exhibited a reduced response to IFN- gamma , with suppressed phosphorylation of STAT-1 compared with uninfected cells. Interaction of M. avium with macrophage receptors increased gene expression of the suppressors of cytokine signaling (SOCS) to diminish IFN responsiveness. Specifically, we observed an increase in mRNA for both SOCS-3 and SOCS-1, which correlates with elevated levels of SOCS protein and positive immunostaining in M. avium/HIV-1 co-infected tissues. We also linked the p38 MAPK signaling pathway to mycobacterial-induced SOCS gene transcription. The induction of SOCS may be part of the strategy that allows the invader to render the macrophages unresponsive to IFN- gamma , which otherwise promotes clearance of the infection. Our data provide new insights into the manipulation of the host response by this opportunistic pathogen and the potential for modulating SOCS to influence the outcome of M. avium infection in immunocompromised hosts. JF - Journal of Leukocyte Biology AU - Vazquez, N AU - Teresa, G-W AU - Rekka, S AU - Orenstein, J M AU - Wahl, S M AD - Building 30, 30 Convent Dr., MSC 4352, OIIB NIDCR, NIH, Bethesda, MD 20892-4352, USA, nvazquez@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1136 EP - 1144 VL - 80 IS - 5 SN - 0741-5400, 0741-5400 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Macrophages KW - Cell survival KW - gamma -Interferon KW - Acquired immune deficiency syndrome KW - Mycobacterium avium KW - TLR2 protein KW - Infection KW - CD14 antigen KW - Gene expression KW - Phosphorylation KW - Human immunodeficiency virus 1 KW - MAP kinase KW - soc gene KW - Data processing KW - Leukocytes KW - Transcription KW - Pathogens KW - Immunity KW - Opportunist infection KW - Interferon KW - Stat1 protein KW - Immunocompromised hosts KW - Microorganisms KW - Toll-like receptors KW - Signal transduction KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19973613?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Mycobacterium+avium-induced+SOCS+contributes+to+resistance+to+IFN-+gamma+-mediated+mycobactericidal+activity+in+human+macrophages&rft.au=Vazquez%2C+N%3BTeresa%2C+G-W%3BRekka%2C+S%3BOrenstein%2C+J+M%3BWahl%2C+S+M&rft.aulast=Vazquez&rft.aufirst=N&rft.date=2006-11-01&rft.volume=80&rft.issue=5&rft.spage=1136&rft.isbn=&rft.btitle=&rft.title=Journal+of+Leukocyte+Biology&rft.issn=07415400&rft_id=info:doi/10.1189%2Fjlb.0306206 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cell survival; Macrophages; gamma -Interferon; MAP kinase; Acquired immune deficiency syndrome; Data processing; soc gene; Leukocytes; TLR2 protein; Transcription; Immunity; Pathogens; CD14 antigen; Infection; Opportunist infection; Gene expression; Interferon; Phosphorylation; Stat1 protein; Immunocompromised hosts; Microorganisms; Toll-like receptors; Signal transduction; Mycobacterium avium; Human immunodeficiency virus 1 DO - http://dx.doi.org/10.1189/jlb.0306206 ER - TY - JOUR T1 - Refined Spatial Manipulation of Neuronal Function by Combinatorial Restriction of Transgene Expression AN - 19967411; 7139355 AB - Selective genetic manipulation of neuronal function in vivo requires techniques for targeting gene expression to specific cells. Existing systems accomplish this using the promoters of endogenous genes to drive expression of transgenes directly in cells of interest or, in "binary" systems, to drive expression of a transcription factor or recombinase that subsequently activates the expression of other transgenes. All such techniques are constrained by the limited specificity of the available promoters. We introduce here a combinatorial system in which the DNA-binding (DBD) and transcription-activation (AD) domains of a transcription factor are independently targeted using two different promoters. The domains heterodimerize to become transcriptionally competent and thus drive transgene expression only at the intersection of the expression patterns of the two promoters. We use this system to dissect a neuronal network in Drosophila by selectively targeting expression of the cell death gene reaper to subsets of neurons within the network. JF - Neuron AU - Luan, Haojiang AU - Peabody, Nathan C AU - Vinson, Charles R AU - White, Benjamin H AD - Laboratory of Molecular Biology, National Institute of Mental Health, 9000 Rockville Pike, Bethesda, Maryland 20892, benjaminwhite@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 425 EP - 436 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 52 IS - 3 SN - 0896-6273, 0896-6273 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Entomology Abstracts KW - MOLNEURO KW - Gene expression KW - Promoters KW - Cell death KW - Neural networks KW - Transcription factors KW - recombinase KW - Transgenes KW - Drosophila KW - W 30925:Genetic Engineering KW - N3 11007:Neurobiology KW - Z 05320:Physiology, Anatomy, and Biochemistry KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19967411?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Refined+Spatial+Manipulation+of+Neuronal+Function+by+Combinatorial+Restriction+of+Transgene+Expression&rft.au=Luan%2C+Haojiang%3BPeabody%2C+Nathan+C%3BVinson%2C+Charles+R%3BWhite%2C+Benjamin+H&rft.aulast=Luan&rft.aufirst=Haojiang&rft.date=2006-11-01&rft.volume=52&rft.issue=3&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Neuron&rft.issn=08966273&rft_id=info:doi/10.1016%2Fj.neuron.2006.08.028 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Promoters; Cell death; Neural networks; recombinase; Transcription factors; Transgenes; Drosophila DO - http://dx.doi.org/10.1016/j.neuron.2006.08.028 ER - TY - JOUR T1 - Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis, Structural Features, and Relative Activities AN - 19931518; 7119341 AB - Recently, using structure-inspired drug design, we demonstrated that aminoalkyl derivatives of {szligbeta}-cyclodextrin inhibited anthrax lethal toxin action by blocking the transmembrane pore formed by the protective antigen (PA) subunit of the toxin. In the present study, we evaluate a series of new {szligbeta}-cyclodextrin derivatives with the goal of identifying potent inhibitors of anthrax toxins. Newly synthesized hepta-6-thioaminoalkyl and hepta-6-thioguanidinoalkyl derivatives of {szligbeta}-cyclodextrin with alkyl spacers of various lengths were tested for the ability to inhibit cytotoxicity of lethal toxin in cells as well as to block ion conductance through PA channels reconstituted in planar bilayer lipid membranes. Most of the tested derivatives were protective against anthrax lethal toxin action at low or submicromolar concentrations. They also blocked ion conductance through PA channels at concentrations as low as 0.1 nM. The activities of the derivatives in both cell protection and channel blocking were found to depend on the length and chemical nature of the substituent groups. One of the compounds was also shown to block the edema toxin activity. It is hoped that these results will help to identify a new class of drugs for anthrax treatment, i.e., drugs that block the pathway for toxin translocation into the cytosol, the PA channel. JF - Antimicrobial Agents & Chemotherapy AU - Karginov, Vladimir A AU - Nestorovich, Ekaterina M AU - Yohannes, Adiamseged AU - Robinson, Tanisha M AU - Fahmi, Nour Eddine AU - Schmidtmann, Frank AU - Hecht, Sidney M AU - Bezrukov, Sergey M AD - Innovative Biologics, Inc., 10900 University Blvd., Manassas, Virginia 20110. Laboratory of Physical and Structural Biology, NICHD, National Institutes of Health, Bethesda, Maryland 20982. Pinnacle Pharmaceuticals, Inc., Emerging Technology Center One, 1670 Discovery Dr., Charlottesville, Virginia 22911. Departments of Chemistry and Biology, University of Virginia, Charlottesville, Virginia 22901 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3740 EP - 3753 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 11 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Anthrax lethal toxin KW - Channel pores KW - Conductance KW - protective antigen KW - Edema KW - Drug development KW - Spacer KW - Antimicrobial agents KW - Cytotoxicity KW - Lipid membranes KW - Cytosol KW - Anthrax KW - Translocation KW - Drugs KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19931518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Search+for+Cyclodextrin-Based+Inhibitors+of+Anthrax+Toxins%3A+Synthesis%2C+Structural+Features%2C+and+Relative+Activities&rft.au=Karginov%2C+Vladimir+A%3BNestorovich%2C+Ekaterina+M%3BYohannes%2C+Adiamseged%3BRobinson%2C+Tanisha+M%3BFahmi%2C+Nour+Eddine%3BSchmidtmann%2C+Frank%3BHecht%2C+Sidney+M%3BBezrukov%2C+Sergey+M&rft.aulast=Karginov&rft.aufirst=Vladimir&rft.date=2006-11-01&rft.volume=50&rft.issue=11&rft.spage=3740&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Anthrax lethal toxin; Conductance; Channel pores; protective antigen; Edema; Spacer; Drug development; Antimicrobial agents; Cytotoxicity; Lipid membranes; Cytosol; Anthrax; Drugs; Translocation ER - TY - JOUR T1 - Connecting genes, drugs and diseases AN - 19853731; 7333135 AB - A large-scale chemical genetic approach for systematically linking gene expression profiles with compounds and phenotypes offers promise for both basic and applied biomedical research. JF - Nature Biotechnology AU - Weinstein, J N AU - Pommier, Y AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Building 37, Room 5068, 37 Convent Drive, Bethesda, Maryland 20892, USA, weinstein@dtpax2.ncifcrf.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1365 EP - 1366 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 24 IS - 11 SN - 1087-0156, 1087-0156 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Phenotypes KW - Drugs KW - W 30905:Medical Applications KW - G 07880:Human Genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19853731?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=unknown&rft.jtitle=The+Journal+of+Nuclear+Medicine&rft.atitle=NIAID+Awards+%244+Million+to+Develop+Anti-Radiation+Treatments&rft.au=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aulast=National+Institute+of+Allergy+and+Infectious+Diseases&rft.aufirst=&rft.date=2006-11-01&rft.volume=47&rft.issue=11&rft.spage=20N&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+Nuclear+Medicine&rft.issn=01615505&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Gene expression; Drugs; Phenotypes DO - http://dx.doi.org/10.1038/nbt1106-1365 ER - TY - JOUR T1 - Oral Glucosamine for 6 Weeks at Standard Doses Does Not Cause or Worsen Insulin Resistance or Endothelial Dysfunction in Lean or Obese Subjects AN - 19848666; 7122098 AB - Glucosamine is a popular nutritional supplement used to treat osteoarthritis. Intravenous administration of glucosamine causes insulin resistance and endothelial dysfunction. However, rigorous clinical studies evaluating the safety of oral glucosamine with respect to metabolic and cardiovascular pathophysiology are lacking. Therefore, we conducted a randomized, placebo-controlled, double-blind, crossover trial of oral glucosamine at standard doses (500 mg p.o. t.i.d.) in lean (n = 20) and obese (n = 20) subjects. Glucosamine or placebo treatment for 6 weeks was followed by a 1-week washout and crossover to the other arm. At baseline, and after each treatment period, insulin sensitivity was assessed by hyperinsulinemic-isoglycemic glucose clamp (SI sub(Clamp)) and endothelial function evaluated by brachial artery blood flow (BAF; Doppler ultrasound) and forearm skeletal muscle microvascular recruitment (ultrasound with microbubble contrast) before and during steady-state hyperinsulinemia. Plasma glucosamine pharmacokinetics after oral dosing were determined in each subject using a high-performance liquid chromatography method. As expected, at baseline, obese subjects had insulin resistance and endothelial dysfunction when compared with lean subjects (SI sub(Clamp) [median {25th-75th percentile}] = 4.3 [2.9-5.3] vs. 7.3 [5.7-11.3], P < 0.0001; insulin-stimulated changes in BAF [% over basal] = 12 [-6 to 84] vs. 39 [2-108], P < 0.04). When compared with placebo, glucosamine did not cause insulin resistance or endothelial dysfunction in lean subjects or significantly worsen these findings in obese subjects. The half-life of plasma glucosamine after oral dosing was similar to 150 min, with no significant changes in steady-state glucosamine levels detectable after 6 weeks of therapy. We conclude that oral glucosamine at standard doses for 6 weeks does not cause or significantly worsen insulin resistance or endothelial dysfunction in lean or obese subjects. JF - Diabetes AU - Muniyappa, Ranganath AU - Karne, Rajaram J AU - Hall, Gail AU - Crandon, Sonja K AU - Bronstein, Joel A AU - Ver, Maria R AU - Hortin, Glen L AU - Quon, Michael J AD - Diabetes Unit, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland. Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3142 EP - 3150 PB - American Diabetes Association, 1701 N. Beauregard St. Alexandria VA 22311 USA, [mailto:customerservice@diabetes.org], [URL:http://www.diabetes.org] VL - 55 IS - 11 SN - 0012-1797, 0012-1797 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - High-performance liquid chromatography KW - Obesity KW - Microvasculature KW - Intravenous administration KW - Doppler effect KW - Osteoarthritis KW - Arteries KW - Glucosamine KW - Recruitment KW - Glucose KW - Hyperinsulinemia KW - Clinical trials KW - Insulin KW - Pharmacokinetics KW - Diabetes mellitus KW - Dietary supplements KW - Skeletal muscle KW - Ultrasound KW - Forearm KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848666?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Diabetes&rft.atitle=Oral+Glucosamine+for+6+Weeks+at+Standard+Doses+Does+Not+Cause+or+Worsen+Insulin+Resistance+or+Endothelial+Dysfunction+in+Lean+or+Obese+Subjects&rft.au=Muniyappa%2C+Ranganath%3BKarne%2C+Rajaram+J%3BHall%2C+Gail%3BCrandon%2C+Sonja+K%3BBronstein%2C+Joel+A%3BVer%2C+Maria+R%3BHortin%2C+Glen+L%3BQuon%2C+Michael+J&rft.aulast=Muniyappa&rft.aufirst=Ranganath&rft.date=2006-11-01&rft.volume=55&rft.issue=11&rft.spage=3142&rft.isbn=&rft.btitle=&rft.title=Diabetes&rft.issn=00121797&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - High-performance liquid chromatography; Microvasculature; Obesity; Intravenous administration; Osteoarthritis; Doppler effect; Glucosamine; Arteries; Recruitment; Glucose; Hyperinsulinemia; Clinical trials; Pharmacokinetics; Insulin; Diabetes mellitus; Dietary supplements; Skeletal muscle; Ultrasound; Forearm ER - TY - JOUR T1 - Experience with experimental biological treatment and local gene therapy in Sjoegren's syndrome: implications for exocrine pathogenesis and treatment AN - 19847701; 7120260 AB - Sjoegren's syndrome is an autoimmune exocrinopathy, mainly affecting the lacrimal and salivary glands, and resulting in ocular and oral dryness (keratoconjunctivitis sicca and xerostomia). The aetiology and pathogenesis are largely unknown, and only palliative treatment is currently available. Data obtained from experimental animal and human studies using biological agents or gene therapeutics can offer insight into the disease process of Sjoegren's syndrome. This article reviews the current literature on these approaches and assesses the lessons learnt about the pathogenesis of Sjoegren's syndrome. JF - Annals of the Rheumatic Diseases AU - Lodde, B M AU - Baum, B J AU - Tak, P P AU - Illei, G AD - Gene Therapy and Therapeutics Branch/NIDCR, National Institutes of Health, DHHS, Bethesda, Maryland, USA. Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, The Netherlands Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1406 EP - 1413 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 65 IS - 11 SN - 0003-4967, 0003-4967 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Sjogren's syndrome KW - Data processing KW - Gene therapy KW - Salivary gland KW - Keratoconjunctivitis KW - xerostomia KW - G 07720:Immunogenetics KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19847701?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+Rheumatic+Diseases&rft.atitle=Experience+with+experimental+biological+treatment+and+local+gene+therapy+in+Sjoegren%27s+syndrome%3A+implications+for+exocrine+pathogenesis+and+treatment&rft.au=Lodde%2C+B+M%3BBaum%2C+B+J%3BTak%2C+P+P%3BIllei%2C+G&rft.aulast=Lodde&rft.aufirst=B&rft.date=2006-11-01&rft.volume=65&rft.issue=11&rft.spage=1406&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+Rheumatic+Diseases&rft.issn=00034967&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sjogren's syndrome; Data processing; Gene therapy; Salivary gland; Keratoconjunctivitis; xerostomia ER - TY - JOUR T1 - Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors AN - 19845016; 7385838 AB - Antiangiogenic gene therapy is a promising strategy for cancer treatment, which generally requires highly efficient delivery systems. To date, success of this strategy has depended almost exclusively on the delivery of high titers of viral vectors, which can result in effective transgene expression. However, their cytotoxicity and immunogenicity are a major concern for clinical applications. Recent advances in delivery efficiency of naked DNA could potentially meet the requirement for both high transgene expression and minimal side effects. To investigate whether naked DNA can be used for antiangiogenic cancer therapy, an expression plasmid was generated that encodes a soluble form of fetal liver kinase-1 (Flk-1) gene, a receptor for vascular endothelial growth factor (VEGF). Hydrodynamic injection of this plasmid resulted in close to 0.1 mg/ml of soluble Flk-1 protein in mouse serum and blocked VEGF-driven angiogenesis in matrigel in vivo. The same delivery significantly suppressed the growth of two different pre-existing subcutaneous tumors, Renca renal cell carcinoma and 3LL lung carcinoma. CD31 immunohistochemistry revealed that the tumor-associated angiogenesis was also highly attenuated in soluble Flk-1- treated mice. Thus, expression of genes by hydrodynamics-based gene delivery of naked DNA appears to be a promising approach for antiangiogenic cancer gene therapy. JF - Cancer Gene Therapy AU - Yazawa, H AU - Murakami, T AU - Li, H-M AU - Back, T AU - Kurosaka, K AU - Suzuki, Y AU - Shorts, L AU - Akiyama, Y AU - Maruyama, K AU - Parsoneault, E AU - Wiltrout, R H AU - Watanabe, M AD - Laboratory of Experimental Immunology, NCI Center for Cancer Research, Frederick, MD, USA, watanabm@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 993 EP - 1001 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 13 IS - 11 SN - 0929-1903, 0929-1903 KW - Virology & AIDS Abstracts; Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - hydrodynamics-based gene delivery KW - VEGF KW - Flk-1 KW - angiogenesis KW - renal cell carcinoma KW - lung carcinoma KW - Vascular endothelial growth factor KW - vascular endothelial growth factor receptor 2 KW - Hydrodynamics KW - Gene therapy KW - Lung carcinoma KW - Angiogenesis KW - Therapeutic applications KW - Tumors KW - Plasmids KW - Expression vectors KW - Cytotoxicity KW - Immunogenicity KW - Gene transfer KW - DNA KW - Vascular endothelial growth factor receptor 2 KW - Immunohistochemistry KW - Side effects KW - W 30905:Medical Applications KW - V 22350:Immunology KW - G 07730:Development & Cell Cycle KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19845016?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Gene+Therapy&rft.atitle=Hydrodynamics-based+gene+delivery+of+naked+DNA+encoding+fetal+liver+kinase-1+gene+effectively+suppresses+the+growth+of+pre-existing+tumors&rft.au=Yazawa%2C+H%3BMurakami%2C+T%3BLi%2C+H-M%3BBack%2C+T%3BKurosaka%2C+K%3BSuzuki%2C+Y%3BShorts%2C+L%3BAkiyama%2C+Y%3BMaruyama%2C+K%3BParsoneault%2C+E%3BWiltrout%2C+R+H%3BWatanabe%2C+M&rft.aulast=Yazawa&rft.aufirst=H&rft.date=2006-11-01&rft.volume=13&rft.issue=11&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Cancer+Gene+Therapy&rft.issn=09291903&rft_id=info:doi/10.1038%2Fsj.cgt.7700970 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; vascular endothelial growth factor receptor 2; Gene therapy; Hydrodynamics; Lung carcinoma; Angiogenesis; Therapeutic applications; Tumors; Plasmids; Expression vectors; Cytotoxicity; renal cell carcinoma; Gene transfer; Immunogenicity; DNA; Vascular endothelial growth factor receptor 2; Immunohistochemistry; Side effects DO - http://dx.doi.org/10.1038/sj.cgt.7700970 ER - TY - JOUR T1 - Dermatitis as a component of the fetal inflammatory response syndrome is associated with activation of Toll-like receptors in epidermal keratinocytes AN - 19844723; 7106728 AB - Aims: Microbial invasion of the amniotic cavity (MIAC) elicits a fetal inflammatory response such as funisitis and chorionic vasculitis. However, little is known about the changes of fetal skin during MIAC. Toll-like receptors recognize microbial products and initiate an immune response. The aims of this study were to examine histopathological features of fetal skin exposed to MIAC and to assess the changes in Toll-like receptor (TLR)-2 and TLR-4 expression. Methods and results: Skin samples were obtained from fetal autopsies (n = 12). The cases were classified according to the presence (n = 8) or absence (n = 4) of acute chorioamnionitis and analysed by immunohistochemistry using a panel of antibodies. Leucocytic infiltrates into the superficial dermis were observed in cases with chorioamnionitis; the majority of inflammatory cells were neutrophils, lymphocytes and histiocytes. TLR-2 immunoreactivity in the skin was stronger in fetuses with chorioamnionitis than in those without this condition. However, immunoreactivity of TLR-4 in the fetal skin was constitutively expressed, regardless of the presence or absence of chorioamnionitis. Conclusions: This study demonstrates for the first time that fetal dermatitis can be detected and is part of the fetal inflammatory response syndrome (FIRS). We propose that this 'FIRS-associated fetal dermatitis' is a fetal counterpart of chorioamnionitis. JF - Histopathology AU - Kim, Y M AU - Romero, R AU - Chaiworapongsa, T AU - Espinoza, J AU - Mor, G AU - Kim, C J AD - Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, MD and Detroit, MI Center for Molecular Medicine and Genetics, warfiela@mail.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 506 EP - 514 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 49 IS - 5 SN - 0309-0167, 0309-0167 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cavities KW - Autopsy KW - Dermis KW - Vasculitis KW - Skin KW - TLR2 protein KW - Leukocytes (neutrophilic) KW - Lymphocytes KW - Fetuses KW - Inflammation KW - Antibodies KW - Chorioamnionitis KW - Immune response KW - Keratinocytes KW - Immunohistochemistry KW - Toll-like receptors KW - Dermatitis KW - A 01490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Histopathology&rft.atitle=Dermatitis+as+a+component+of+the+fetal+inflammatory+response+syndrome+is+associated+with+activation+of+Toll-like+receptors+in+epidermal+keratinocytes&rft.au=Kim%2C+Y+M%3BRomero%2C+R%3BChaiworapongsa%2C+T%3BEspinoza%2C+J%3BMor%2C+G%3BKim%2C+C+J&rft.aulast=Kim&rft.aufirst=Y&rft.date=2006-11-01&rft.volume=49&rft.issue=5&rft.spage=506&rft.isbn=&rft.btitle=&rft.title=Histopathology&rft.issn=03090167&rft_id=info:doi/10.1111%2Fj.1365-2559.2006.02542.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - SuppNotes - Figures, 4; tables, 2; references, 31. N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Autopsy; Cavities; Dermis; Skin; Vasculitis; TLR2 protein; Leukocytes (neutrophilic); Lymphocytes; Fetuses; Inflammation; Antibodies; Chorioamnionitis; Keratinocytes; Immune response; Immunohistochemistry; Toll-like receptors; Dermatitis DO - http://dx.doi.org/10.1111/j.1365-2559.2006.02542.x ER - TY - JOUR T1 - Expression of Mutated Mouse Myocilin Induces Open-Angle Glaucoma in Transgenic Mice AN - 19838459; 7167020 AB - We developed a genetic mouse model of open-angle glaucoma by expression of mutated mouse myocilin (Myoc) in transgenic (Tg) mice. The Tyr423His point mutation, corresponding to the severe glaucoma-causing Tyr437His mutation in the human MYOC gene, was introduced into bacterial artificial chromosome DNA encoding the full-length mouse Myoc gene and long flanking regions. Both wild-type (Wt) and Tg animals expressed Myoc in tissues of the irido-corneal angle and the sclera. Expression of mutated Myoc induced the accumulation of Myoc in cell cytoplasm and prevented its secretion into the extracellular space. The levels of ATPase-1 were reduced in the irido-corneal angle of Tg mice compared with Wt animals. Tg mice demonstrated a moderate elevation of intraocular pressure, the loss of similar to 20% of the retinal ganglion cells (RGCs) in the peripheral retina, and axonal degeneration in the optic nerve. RGC depletion was associated with the shrinkage of their nuclei and DNA fragmentation in the peripheral retina. Pathological changes observed in the eyes of Tg mice are similar to those observed in glaucoma patients. JF - Journal of Neuroscience AU - Senatorov, Vladimir AU - Malyukova, Irina AU - Fariss, Robert AU - Wawrousek, Eric F AU - Swaminathan, Srividya AU - Sharan, Shyam K AU - Tomarev, Stanislav AD - Section of Molecular Mechanisms of Glaucoma, Laboratory of Molecular and Developmental Biology, and Biological Imaging Core, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, and Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 11903 EP - 11914 PB - Society for Neuroscience, 11 Dupont Circle, N.W. Suite 500 Washington DC 20036 USA, [mailto:info@sfn.org], [URL:http://apu.sfn.org/] VL - 26 IS - 46 SN - 0270-6474, 0270-6474 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Retina KW - Retinal ganglion cells KW - Secretion KW - Point mutation KW - Animal models KW - MYOC gene KW - Transgenic mice KW - Neurodegeneration KW - Optic nerve KW - Bacterial artificial chromosomes KW - DNA fragmentation KW - Nervous system KW - Glaucoma KW - Cytoplasm KW - Atrophy KW - Pressure KW - J 02410:Animal Diseases KW - W 30925:Genetic Engineering KW - N3 11004:Motor & sensory systems KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neuroscience&rft.atitle=Expression+of+Mutated+Mouse+Myocilin+Induces+Open-Angle+Glaucoma+in+Transgenic+Mice&rft.au=Senatorov%2C+Vladimir%3BMalyukova%2C+Irina%3BFariss%2C+Robert%3BWawrousek%2C+Eric+F%3BSwaminathan%2C+Srividya%3BSharan%2C+Shyam+K%3BTomarev%2C+Stanislav&rft.aulast=Senatorov&rft.aufirst=Vladimir&rft.date=2006-11-01&rft.volume=26&rft.issue=46&rft.spage=11903&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neuroscience&rft.issn=02706474&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Retina; Retinal ganglion cells; Secretion; Point mutation; Animal models; MYOC gene; Transgenic mice; Neurodegeneration; Bacterial artificial chromosomes; Optic nerve; DNA fragmentation; Nervous system; Glaucoma; Cytoplasm; Atrophy; Pressure ER - TY - JOUR T1 - Derivation of an In Vivo Drug Exposure Breakpoint for Flucytosine against Candida albicans and Impact of the MIC, Growth Rate, and Resistance Genotype on the Antifungal Effect AN - 19838169; 7119333 AB - Drug exposure or pharmacodynamic breakpoints refer to a magnitude of drug exposure which separates a population into groups with high and low probabilities of attaining a desired outcome. We used a pharmacodynamic model of disseminated candidiasis to define an in vivo drug exposure breakpoint for flucytosine (5FC) against Candida albicans. The results were bridged to humans by using population pharmacokinetics and Monte Carlo simulation. An in vivo drug exposure breakpoint for 5FC was apparent when serum levels were above the MIC for 45% of the dosing interval. The Monte Carlo simulations suggested that using a human dose of 100 mg/kg of body weight/day in four divided doses, 5FC resistance was defined at an MIC of 32 mg/liter. Target attainment rates following administration of 25, 50, and 100 mg/kg/day were similar, suggesting that the use of a lower dose of 5FC is possible. Using six isolates of C. albicans with MICs ranging from 0.06 to >64 mg/liter, we also explored the influence that the MIC, the fraction of the dosing interval that the serum levels of 5FC remained above the MIC (T>MIC), the 5FC resistance genotype, and the in vivo growth rate had on the response to 5FC. The MIC and T>MIC were both critical measures affecting the generation of a drug effect but had no bearing on the magnitude of the maximal kill induced by 5FC. The in vivo growth rate was a critical additional determinant of the exposure-response relationship. There was a relationship between the 5FC resistance genotype and the exposure-response relationship. JF - Antimicrobial Agents & Chemotherapy AU - Hope, William W AU - Warn, Peter A AU - Sharp, Andrew AU - Howard, Susan AU - Kasai, Miki AU - Louie, Arnold AU - Walsh, Thomas J AU - Drusano, George L AU - Denning, David W AD - School of Medicine, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, United Kingdom. Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr., Bethesda, Maryland 20892. Ordway Research Institute, 150 New Scotland Avenue, Albany, New York 12208. Wythenshawe Hospital, Southmoor Rd., Manchester, M23 9LT, United Kingdom Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3680 EP - 3688 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 11 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Monte Carlo simulation KW - Growth rate KW - Candidiasis KW - Candida albicans KW - Genotypes KW - Minimum inhibitory concentration KW - Pharmacokinetics KW - flucytosine KW - Models KW - Antimicrobial agents KW - Serum levels KW - Breakpoints KW - Body weight KW - Dose-response effects KW - Drugs KW - Pharmacodynamics KW - K 03340:Effects of Physical & Chemical Factors KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19838169?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Derivation+of+an+In+Vivo+Drug+Exposure+Breakpoint+for+Flucytosine+against+Candida+albicans+and+Impact+of+the+MIC%2C+Growth+Rate%2C+and+Resistance+Genotype+on+the+Antifungal+Effect&rft.au=Hope%2C+William+W%3BWarn%2C+Peter+A%3BSharp%2C+Andrew%3BHoward%2C+Susan%3BKasai%2C+Miki%3BLouie%2C+Arnold%3BWalsh%2C+Thomas+J%3BDrusano%2C+George+L%3BDenning%2C+David+W&rft.aulast=Hope&rft.aufirst=William&rft.date=2006-11-01&rft.volume=50&rft.issue=11&rft.spage=3680&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Growth rate; Monte Carlo simulation; Candidiasis; Genotypes; Minimum inhibitory concentration; flucytosine; Pharmacokinetics; Antimicrobial agents; Models; Serum levels; Breakpoints; Body weight; Dose-response effects; Drugs; Pharmacodynamics; Candida albicans ER - TY - JOUR T1 - Cytoplasmic Targeting Motifs Control Localization of Toll-like Receptor 9 AN - 19835784; 7166544 AB - Toll-like receptors (TLRs) are essential for host defense. Although several TLRs reside on the cell surface, nucleic acid recognition of TLRs occurs intracellularly. For example, the receptor for CpG containing bacterial and viral DNA, TLR9, is retained in the endoplasmic reticulum. Recent evidence suggests that the localization of TLR9 is critical for appropriate ligand recognition. Here we have defined which structural features of the TLR9 molecule control its intracellular localization. Both the cytoplasmic and ectodomains of TLR9 contain sufficient information, whereas the transmembrane domain plays no role in intracellular localization. We identify a 14-amino acid stretch that directs TLR9 intracellularly and confers intracellular localization to the normally cell surface-expressed TLR4. Truncation or mutation of the cytoplasmic tail of TLR9 reveals a vesicle localization motif that targets early endosomes. We propose a model whereby modification of the cytoplasmic tail of TLR9 results in trafficking to early endosomes where it encounters CpG DNA. JF - Journal of Biological Chemistry AU - Leifer, Cynthia A AU - Brooks, James C AU - Hoelzer, Karin AU - Lopez, Jody AU - Kennedy, Margaret N AU - Mazzoni, Alessandra AU - Segal, David M AD - Cornell University College of Veterinary Medicine, Ithaca, New York 14853 and Experimental Immunology Branch, NCI, National Institutes of Health, Bethesda, Maryland 20892-1360 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 35585 EP - 35592 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 46 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Cell surface KW - Protein transport KW - TLR9 protein KW - CpG islands KW - Transmembrane domains KW - Endoplasmic reticulum KW - endosomes KW - nucleic acids KW - Vesicles KW - TLR4 protein KW - Mutation KW - Toll-like receptors KW - J 02350:Immunology KW - F 06960:Molecular Immunology KW - V 22310:Genetics, Taxonomy & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19835784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Cytoplasmic+Targeting+Motifs+Control+Localization+of+Toll-like+Receptor+9&rft.au=Leifer%2C+Cynthia+A%3BBrooks%2C+James+C%3BHoelzer%2C+Karin%3BLopez%2C+Jody%3BKennedy%2C+Margaret+N%3BMazzoni%2C+Alessandra%3BSegal%2C+David+M&rft.aulast=Leifer&rft.aufirst=Cynthia&rft.date=2006-11-01&rft.volume=281&rft.issue=46&rft.spage=35585&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Cell surface; Endoplasmic reticulum; endosomes; nucleic acids; TLR9 protein; Vesicles; CpG islands; Transmembrane domains; Mutation; TLR4 protein; Toll-like receptors ER - TY - JOUR T1 - Long-term safety of cardiac magnetic resonance imaging performed in the first few days after bare-metal stent implantation AN - 19685070; 7459268 AB - To investigate the long-term safety of cardiac magnetic resonance imaging (CMR) performed one to seven days after coronary artery stent (bare metal) implantation. We analyzed 119 consecutive patients with acute myocardial infarction (MI) who underwent emergency coronary stent implantation with a bare- metal stent. CMR using a 1.5T scanner was performed on 51 patients (42.9%) at a mean of 2.7 +/- 3.1 days after stent implantation (CMR+ group), and the remaining 68 patients (57.1%) served as controls (CMR- group). The patients were followed up to six months for major adverse cardiac events. The average stent size was 3.3 +/- 0.5 X 18.4 +/- 6.7 mm, and 86% of the stents were made of 316L stainless steel. There were no significant differences between the CMR+ and CMR- groups in terms of infarct features, angiographic findings, or stent characteristics. Over a mean follow-up of 4.4 +/- 2.1 months, 12 patients (10.1%) had 16 events (13.4%). Two patients had adverse events after early MRI scan (4.3%), a rate that is lower than the event rate in the patients who did not undergo MRI (16%, P = 0.04), and one of the two events was clearly not MRI related. CMR on a 1.5T scanner can be safely performed within one to seven days after coronary bare-metal stent implantation and is not associated with an increased risk of adverse clinical cardiac outcomes. In the light of accumulating data, the guidelines by stent manufacturers should be revised. J. Magn. Reson. Imaging 2006. JF - Journal of Magnetic Resonance Imaging AU - Syed, Mushabbar A AU - Carlson, Karen AU - Murphy, Mandy AU - Ingkanisorn, WPatricia AU - Rhoads, Kenneth L AU - Arai, Andrew E AD - Laboratory of Cardiac Energetics, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA, araia@nhlbi.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 1056 EP - 1061 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 24 IS - 5 SN - 1053-1807, 1053-1807 KW - Biotechnology and Bioengineering Abstracts KW - magnetic resonance imaging KW - heart KW - safety KW - stent KW - myocardial infarction KW - Heart KW - Metals KW - Magnetic resonance imaging KW - Myocardial infarction KW - coronary artery KW - stainless steel KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19685070?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Magnetic+Resonance+Imaging&rft.atitle=Long-term+safety+of+cardiac+magnetic+resonance+imaging+performed+in+the+first+few+days+after+bare-metal+stent+implantation&rft.au=Syed%2C+Mushabbar+A%3BCarlson%2C+Karen%3BMurphy%2C+Mandy%3BIngkanisorn%2C+WPatricia%3BRhoads%2C+Kenneth+L%3BArai%2C+Andrew+E&rft.aulast=Syed&rft.aufirst=Mushabbar&rft.date=2006-11-01&rft.volume=24&rft.issue=5&rft.spage=1056&rft.isbn=&rft.btitle=&rft.title=Journal+of+Magnetic+Resonance+Imaging&rft.issn=10531807&rft_id=info:doi/10.1002%2Fjmri.20740 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Heart; Metals; Magnetic resonance imaging; Myocardial infarction; stainless steel; coronary artery DO - http://dx.doi.org/10.1002/jmri.20740 ER - TY - JOUR T1 - The Mortality Risk of Smoking and Obesity Combined AN - 19657012; 8791141 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Freedman, D Michal AU - Sigurdson, Alice J AU - Rajaraman, Preetha AU - Doody, Michele M AU - Linet, Martha S AU - Ron, Elaine AD - National Cancer Institute, Division of Epidemiology and Genetics, Bethesda, Maryland, mf101e@nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 355 EP - 362 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 31 IS - 5 SN - 0749-3797, 0749-3797 KW - Physical Education Index; Health & Safety Science Abstracts; Risk Abstracts KW - Mortality KW - Obesity KW - Death KW - obesity KW - Smoking KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19657012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=The+Mortality+Risk+of+Smoking+and+Obesity+Combined&rft.au=Freedman%2C+D+Michal%3BSigurdson%2C+Alice+J%3BRajaraman%2C+Preetha%3BDoody%2C+Michele+M%3BLinet%2C+Martha+S%3BRon%2C+Elaine&rft.aulast=Freedman&rft.aufirst=D&rft.date=2006-11-01&rft.volume=31&rft.issue=5&rft.spage=355&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2006.07.022 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obesity; Smoking; Death; Mortality; obesity DO - http://dx.doi.org/10.1016/j.amepre.2006.07.022 ER - TY - JOUR T1 - Overproduction, purification, and biochemical characterization of the dual specificity H1 protein phosphatase encoded by variola major virus AN - 19608431; 8586343 AB - Smallpox, a highly contagious infectious disease caused by the variola major virus, has an overall mortality rate of about 30%. Because there currently is no specific treatment for smallpox, and the only prevention is vaccination, there is an urgent need for the development of effective antiviral drugs. The dual specificity protein phosphatase encoded by the smallpox virus (H1) is essential for the production of infectious viral particles, making it a promising molecular target for antiviral therapeutics. Here, we report the molecular cloning, overproduction, purification, and initial biochemical characterization of H1 phosphatase, thereby paving the way for the discovery of small molecule inhibitors. JF - Protein Expression and Purification AU - Tropea, Joseph E AU - Phan, Jason AU - Waugh, David S AD - Macromolecular Crystallography Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD, USA, waughd@ncifcrf.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 31 EP - 36 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Smallpox KW - Variola major KW - Dual specificity phosphatase KW - H1 phosphatase KW - H1L KW - Mortality KW - Antiviral agents KW - Infectious diseases KW - Variola KW - Drug development KW - protein purification KW - protein phosphatase KW - Vaccination KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19608431?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Overproduction%2C+purification%2C+and+biochemical+characterization+of+the+dual+specificity+H1+protein+phosphatase+encoded+by+variola+major+virus&rft.au=Tropea%2C+Joseph+E%3BPhan%2C+Jason%3BWaugh%2C+David+S&rft.aulast=Tropea&rft.aufirst=Joseph&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=31&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.05.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Smallpox; Mortality; Infectious diseases; Antiviral agents; Drug development; protein purification; Vaccination; protein phosphatase; Variola DO - http://dx.doi.org/10.1016/j.pep.2006.05.007 ER - TY - JOUR T1 - Production and characterization of clinical grade Escherichia coli derived Plasmodium falciparum 42 kDa merozoite surface protein 1 (MSP1 sub(42)) in the absence of an affinity tag AN - 19607894; 8586347 AB - The 42 kDa cleavage product from the carboxyl end of the Plasmodium falciparum merozoite surface protein 1 (MSP1 sub(42)) is an important blood-stage malaria vaccine target. Several recombinant protein expression systems have been used for production of MSP1 sub(42) including yeast (Saccharomyces cerevisiae and Pichia pastoris), Escherichia coli, baculovirus and transgenic animals. To date, all of the reported recombinant proteins include a 6x His affinity tag to facilitate purification, including three MSP1 sub(42) clinical grade proteins currently in human trials. Under some circumstances, the presence of the 6x His tag may not be desirable. Therefore, we were interested to produce clinical grade MSP1 sub(42) without a 6x His affinity tag from E. coli inclusion bodies. We produced a recombinant MSP1 sub(42) with a P. falciparum FUP (Uganda-Palo Alto) phenotype which accounts for a substantial proportion of the MSP1 sub(42) protein observed in African isolates. EcMSP1 sub(42)-FUP was produced in E. coli inclusion bodies by high cell mass induction with IPTG using 5 L and 60 L bioreactors. Isolated inclusion bodies were solubilized in 8 M guanidine-HCl and the EcMSP1 sub(42)-FUP protein refolded by rapid dilution. Refolded EcMSP1 sub(42)-FUP was purified using hydrophobic interaction chromatography, anion exchange chromatography, and size exclusion chromatography, and subject to biochemical characterization for integrity, identity, and purity. Endotoxin and host cell protein levels were within acceptable limits for human use. The process was successfully transferred to pilot-scale production in a cGMP environment. A final recovery of 87.8 mg of clinical-grade material per liter of fermentation broth was achieved. The EcMSP1 sub(42)-FUP clinical antigen is available for preclinical evaluation and human studies. JF - Protein Expression and Purification AU - Shimp, Richard L AU - Martin, Laura B AU - Zhang, Yanling AU - Henderson, Brian S AU - Duggan, Peter AU - MacDonald, Nicholas J AU - Lebowitz, Jacob AU - Saul, Allan AU - Narum, David L AD - Malaria Vaccine Development Branch (MVDB), NIAID/NIH/DHHS, Rockville, MD, USA, dnarum@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 58 EP - 67 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 50 IS - 1 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Aqualine Abstracts; Biotechnology and Bioengineering Abstracts KW - Analytical Methods KW - Africa KW - Proteins KW - protein purification KW - Baculovirus KW - AQ 00001:Water Resources and Supplies KW - J 02410:Animal Diseases KW - K 03330:Biochemistry KW - A 01490:Miscellaneous KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Production+and+characterization+of+clinical+grade+Escherichia+coli+derived+Plasmodium+falciparum+42+kDa+merozoite+surface+protein+1+%28MSP1+sub%2842%29%29+in+the+absence+of+an+affinity+tag&rft.au=Shimp%2C+Richard+L%3BMartin%2C+Laura+B%3BZhang%2C+Yanling%3BHenderson%2C+Brian+S%3BDuggan%2C+Peter%3BMacDonald%2C+Nicholas+J%3BLebowitz%2C+Jacob%3BSaul%2C+Allan%3BNarum%2C+David+L&rft.aulast=Shimp&rft.aufirst=Richard&rft.date=2006-11-01&rft.volume=50&rft.issue=1&rft.spage=58&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2014-02-11 N1 - SubjectsTermNotLitGenreText - protein purification; Proteins; Baculovirus; Africa DO - http://dx.doi.org/10.1016/j.pep.2006.06.018 ER - TY - JOUR T1 - Antitumor Activity of Liposomal Naphthoquinone Esters Isolated from Thai Medicinal Plant: Rhinacanthus nasutus Kurz AN - 19586398; 7305088 AB - We previously observed that rhinacanthins-C, -N and -Q, three main naphthoquinone esters isolated from the roots of Thai medicinal plant; Rhinacanthus nasutus Kurz. (Acanthaceae) induced apoptosis of human cervical carcinoma HeLaS3 cells. Since these rhinacanthins showed limited solubility in aqueous medium, we attempted to entrap them into liposomal membrane: Liposomalization enabled injection of the drugs and the drugs were expected to transfer to lipoproteins in the bloodstream. Liposomal formulations of rhinacanthins-C, -N and -Q showed strong antiproliferative activity against HeLaS3 cells with the IC sub(50) values of 32,17, 70 mu M; 19, 17, 52 mu m and 2.7, 2.0 and 5.0 mu M for the exposure time of 24, 48, and 72 h, respectively. These liposomes suppressed the tumor growth in Meth-A sarcoma-bearing BALB/c mice at the dose of 5.0 mg/kg/d for 10 d. Among rhinacanthins, liposomal rhinacanthin-N significantly suppressed solid tumor growth. Based on these results, our findings demonstrated that rhinacanthin-N suppressed tumor growth in vivo, and suggested that liposomes are useful for preparing injectable formulation of hydrophobic drugs. JF - Biological & Pharmaceutical Bulletin AU - Siripong, P AU - Yahuafai, J AU - Shimizu, K AU - Ichikawa, K AU - Yonezawa, S AU - Asai, T AU - Kanokmedakul, K AU - Ruchirawat, S AU - Oku, N AD - Natural Products Research Section, Research Division, National Cancer Institute; Bangkok 10400, Thailand, Oku@u-shizuoka-ken.ac.jp Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2279 EP - 2283 VL - 29 IS - 11 SN - 0918-6158, 0918-6158 KW - Acanthus KW - Biotechnology and Bioengineering Abstracts KW - Cervical carcinoma KW - Solubility KW - Apoptosis KW - Solid tumors KW - Medicinal plants KW - Hydrophobicity KW - Tumors KW - Acanthaceae KW - Esters KW - Liposomes KW - Lipoproteins KW - Rhinacanthus nasutus KW - Drugs KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19586398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+%26+Pharmaceutical+Bulletin&rft.atitle=Antitumor+Activity+of+Liposomal+Naphthoquinone+Esters+Isolated+from+Thai+Medicinal+Plant%3A+Rhinacanthus+nasutus+Kurz&rft.au=Siripong%2C+P%3BYahuafai%2C+J%3BShimizu%2C+K%3BIchikawa%2C+K%3BYonezawa%2C+S%3BAsai%2C+T%3BKanokmedakul%2C+K%3BRuchirawat%2C+S%3BOku%2C+N&rft.aulast=Siripong&rft.aufirst=P&rft.date=2006-11-01&rft.volume=29&rft.issue=11&rft.spage=2279&rft.isbn=&rft.btitle=&rft.title=Biological+%26+Pharmaceutical+Bulletin&rft.issn=09186158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cervical carcinoma; Apoptosis; Solubility; Solid tumors; Lipoproteins; Medicinal plants; Hydrophobicity; Tumors; Esters; Liposomes; Drugs; Antitumor activity; Rhinacanthus nasutus; Acanthaceae ER - TY - JOUR T1 - Granulibacter bethesdensis gen. nov., sp. nov., a distinctive pathogenic acetic acid bacterium in the family Acetobacteraceae AN - 19556214; 7271383 AB - A Gram-negative, aerobic, coccobacillus to rod-shaped bacterium was isolated from three patients with chronic granulomatous disease. The organism was subjected to a polyphasic taxonomic study. A multilocus phylogenetic analysis based on the 16S rRNA gene, the internal transcribed spacer (ITS) region and the RecA protein demonstrated that the organism belongs to a new sublineage within the acetic acid bacteria in the family Acetobacteraceae. Phenotypic features are summarized as follows: the organism grew at an optimum temperature of 35-37 not equal to and optimum pH of 5.0-6.5. It produced a yellow pigment, oxidized lactate and acetate, the latter weakly, produced little acetic acid from ethanol and could use methanol as a sole carbon source. The two major fatty acids were a straight-chain unsaturated acid (C18 : 1[omega]7c) and C16 : 0. The DNA base composition was 59.1 mol% G+C. The very weak production of acetic acid from ethanol, the ability to use methanol, the yellow pigmentation and high optimum temperature for growth distinguished this organism from other acetic acid bacteria. The unique phylogenetic and phenotypic characteristics suggest that the bacterium should be classified within a separate genus, for which the name Granulibacter bethesdensis gen. nov., sp. nov. is proposed. The type strain is CGDNIH1 super(T) (=ATCC BAA-1260 super(T)=DSM 17861 super(T)). JF - International Journal of Systematic and Evolutionary Microbiology AU - Greenberg, David E AU - Porcella, Stephen F AU - Stock, Frida AU - Wong, Alexandra AU - Conville, Patricia S AU - Murray, Patrick R AU - Holland, Steven M AU - Zelazny, Adrian M AD - Immunopathogenesis Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, US Department of Health and Human Services, Bethesda, MD 20892, USA, degreenberg@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2609 EP - 2616 PB - Society for General Microbiology, Marlborough House, Basingstoke Road Spencers Wood Reading RG7 1AG UK, [URL:http://www.sgm.ac.uk/] VL - 56 IS - 11 SN - 1466-5026, 1466-5026 KW - Microbiology Abstracts B: Bacteriology KW - Phylogeny KW - Temperature effects KW - Pigmentation KW - Methanol KW - Carbon sources KW - Base composition KW - Pigments KW - Lactic acid KW - Fatty acids KW - DNA KW - Acetic acid bacteria KW - Chronic granulomatous disease KW - rRNA 16S KW - pH effects KW - RecA protein KW - Ethanol KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19556214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.atitle=Granulibacter+bethesdensis+gen.+nov.%2C+sp.+nov.%2C+a+distinctive+pathogenic+acetic+acid+bacterium+in+the+family+Acetobacteraceae&rft.au=Greenberg%2C+David+E%3BPorcella%2C+Stephen+F%3BStock%2C+Frida%3BWong%2C+Alexandra%3BConville%2C+Patricia+S%3BMurray%2C+Patrick+R%3BHolland%2C+Steven+M%3BZelazny%2C+Adrian+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2006-11-01&rft.volume=56&rft.issue=11&rft.spage=2609&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Systematic+and+Evolutionary+Microbiology&rft.issn=14665026&rft_id=info:doi/10.1099%2Fijs.0.64412-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-04-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Temperature effects; Phylogeny; Pigmentation; Methanol; Carbon sources; Base composition; Pigments; DNA; Fatty acids; Lactic acid; Acetic acid bacteria; Chronic granulomatous disease; pH effects; rRNA 16S; RecA protein; Ethanol DO - http://dx.doi.org/10.1099/ijs.0.64412-0 ER - TY - JOUR T1 - Structure-based mutagenesis of SigE verifies the importance of hydrophobic and electrostatic residues in type III chaperone function AN - 19543544; 7168612 AB - Despite sharing little sequence identity, most type III chaperones display a similar homodimeric structure characterized by negative charges distributed broadly over their entire surface, interspersed with hydrophobic patches. Here we have used SigE from Salmonella as a model for class IA type III chaperones to investigate the role of these surface-exposed residues in chaperone function. SigE is essential for the stability, secretion and translocation of its cognate effector, SopB (SigD). We analysed the effect of mutating nine conserved hydrophobic and electronegative surface-exposed amino acids of SigE on SopB binding, stability, secretion and translocation. Six of these mutations affected some aspect of SigE function (Leu14, Asp20, Leu22, Leu23, Ile25 and Asp51) and three were without effect (Leu54, Glu92 and Glu99). Our results highlight that both hydrophobic and electronegative surfaces are required for the function of SigE and provide an important basis for the prediction of side-chain requirements for other chaperone-effector pairs. JF - Molecular Microbiology AU - Knodler, Leigh A AU - Bertero, Michela AU - Yip, Calvin AU - Strynadka, Natalie CJ AU - Steele-Mortimer, Olivia AD - Laboratory of Intracellular Parasites, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, MT 59840, USA, lknodler@niaid.nih.gov Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 928 EP - 940 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 62 IS - 4 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts B: Bacteriology KW - Amino acids KW - Hydrophobicity KW - Chaperones KW - Salmonella KW - Translocation KW - Mutation KW - Mutagenesis KW - Models KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19543544?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Structure-based+mutagenesis+of+SigE+verifies+the+importance+of+hydrophobic+and+electrostatic+residues+in+type+III+chaperone+function&rft.au=Knodler%2C+Leigh+A%3BBertero%2C+Michela%3BYip%2C+Calvin%3BStrynadka%2C+Natalie+CJ%3BSteele-Mortimer%2C+Olivia&rft.aulast=Knodler&rft.aufirst=Leigh&rft.date=2006-11-01&rft.volume=62&rft.issue=4&rft.spage=928&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05418.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 5; tables, 3; references, 58. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Amino acids; Chaperones; Hydrophobicity; Mutation; Translocation; Models; Mutagenesis; Salmonella DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05418.x ER - TY - JOUR T1 - Platelet activation, upregulation of CDllb/CD18 expression on leukocytes and increase in circulating leukocyte-platelet aggregates in Indian women chronically exposed to biomass smoke AN - 19504323; 7194793 AB - The majority of households in rural India still rely on unprocessed solid biomass for domestic energy. The aim of this study was to investigate whether chronic exposure to biomass smoke causes activation of leukocytes and the formation of leukocyte-platelet aggregates. We conducted flow cytometric analysis of beta sub(2) Mac-1 integrin (CDllb/CD18) expression on polymorphonuclear leukocytes (PMN) and monocytes, and P-selectin (CD62P) expression on the platelets of 165 women from eastern India, who cook solely with wood, dung and agricultural wastes, and 155 age- and socio-economic condition-matched control subjects, who used relatively cleaner fuel, liquefied petroleum gas (LPG). Leukocyte-platelet aggregates were defined as CD11b-positive PMN and monocytes co-expressing platelet-specific markers CD41 or CD62P. A significant increase in leukocyte-platelet aggregates was found in women who used biomass as cooking fuel. In addition, they showed increased surface expression of CDllb/CD18 in circulating PMN and monocytes and CD62P expression on platelets. The mean fluorescence intensity (MFI) of CD11b on the surface of circulating monocytes and PMN of biomass users increased by 50 and 68%, respectively. Similarly, a 62 and 48% increase in MFI was observed in CD18 expression on the surface of these cells in biomass users. The results show that chronic biomass smoke exposure activates circulating platelets, PMN and monocytes, and increases the number of leukocyte-platelet aggregates, which are considered a risk factor for thrombosis. JF - Human & Experimental Toxicology AU - Ray, M R AU - Mukherjee, S AU - Roychoudhury, S AU - Bhattacharya, P AU - Banerjee, M AU - Siddique, S AU - Chakraborty, S AU - Lahiri, T AD - Experimental Hematology Unit, Chittaranjan National Cancer Institute, 37, SP Mukherjee Road, Kolkata 700 026, India, manasrray@rediffmail.com Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 627 EP - 635 VL - 25 IS - 11 SN - 0960-3271, 0960-3271 KW - Toxicology Abstracts KW - Fluorescence KW - Fuels KW - Leukocytes (polymorphonuclear) KW - Agricultural wastes KW - Leukocytes KW - P-selectin KW - Biomass KW - CD18 antigen KW - Thrombosis KW - Cell activation KW - Flow cytometry KW - Smoke KW - Chronic exposure KW - Mac1 protein KW - Integrins KW - CD11b antigen KW - Energy KW - Petroleum KW - Risk factors KW - Cooking KW - Dung KW - Platelets KW - Monocytes KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19504323?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+%26+Experimental+Toxicology&rft.atitle=Platelet+activation%2C+upregulation+of+CDllb%2FCD18+expression+on+leukocytes+and+increase+in+circulating+leukocyte-platelet+aggregates+in+Indian+women+chronically+exposed+to+biomass+smoke&rft.au=Ray%2C+M+R%3BMukherjee%2C+S%3BRoychoudhury%2C+S%3BBhattacharya%2C+P%3BBanerjee%2C+M%3BSiddique%2C+S%3BChakraborty%2C+S%3BLahiri%2C+T&rft.aulast=Ray&rft.aufirst=M&rft.date=2006-11-01&rft.volume=25&rft.issue=11&rft.spage=627&rft.isbn=&rft.btitle=&rft.title=Human+%26+Experimental+Toxicology&rft.issn=09603271&rft_id=info:doi/10.1177%2F0960327106074603 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Fluorescence; Agricultural wastes; Leukocytes (polymorphonuclear); Fuels; Leukocytes; P-selectin; Biomass; CD18 antigen; Thrombosis; Cell activation; Smoke; Flow cytometry; Integrins; Mac1 protein; Chronic exposure; Risk factors; Petroleum; Energy; CD11b antigen; Cooking; Platelets; Dung; Monocytes DO - http://dx.doi.org/10.1177/0960327106074603 ER - TY - JOUR T1 - Role of DNA Polymerase IV in Escherichia coli SOS Mutator Activity AN - 19471496; 7166359 AB - Constitutive expression of the SOS regulon in Escherichia coli recA730 strains leads to a mutator phenotype (SOS mutator) that is dependent on DNA polymerase V (umuDC gene product). Here we show that a significant fraction of this effect also requires DNA polymerase IV (dinB gene product). JF - Journal of Bacteriology AU - Kuban, Wojciech AU - Banach-Orlowska, Magdalena AU - Schaaper, Roel M AU - Jonczyk, Piotr AU - Fijalkowska, Iwona J AD - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, 02 106 Warsaw, Poland. Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 7977 EP - 7980 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 22 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - umuDC gene KW - dinB gene KW - DNA-directed DNA polymerase KW - Escherichia coli KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19471496?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+DNA+Polymerase+IV+in+Escherichia+coli+SOS+Mutator+Activity&rft.au=Kuban%2C+Wojciech%3BBanach-Orlowska%2C+Magdalena%3BSchaaper%2C+Roel+M%3BJonczyk%2C+Piotr%3BFijalkowska%2C+Iwona+J&rft.aulast=Kuban&rft.aufirst=Wojciech&rft.date=2006-11-01&rft.volume=188&rft.issue=22&rft.spage=7977&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - umuDC gene; dinB gene; DNA-directed DNA polymerase; Escherichia coli ER - TY - JOUR T1 - CT Colonography with Computer-aided Polyp Detection: Volume and Attenuation Thresholds to Reduce False-Positive Findings Owing to the Ileocecal Valve AN - 19464827; 7126607 AB - PURPOSE: To retrospectively identify volume and average attenuation thresholds for differentiating between ileocecal valve (ICV) and polyp at computed tomographic (CT) colonography with computer-aided detection (CAD). MATERIALS AND METHODS: Informed consent (with consent for future retrospective research) and institutional review board (IRB) approval were obtained for the original prospective study. This retrospective study had IRB approval, as well, and was HIPAA-compliant. A total of 496 patients were selected from a larger screening population. CT colonographic images from 394 patients (227 men, 167 women; mean age, 58.0 years; range, 40-79 years) were used as a training set, and images from 102 patients (76 men, 26 women; mean age, 59.8 years; range, 46-79 years) were used as a test set. A series of 2742 volume and attenuation thresholds, for which segmented findings both larger in volume and lower in average attenuation were labeled as ICVs and remaining findings were labeled polyps, were applied to the training set to determine settings with 100% sensitivity for polyp detection and the highest specificity for ICV detection. The optimal settings were then applied to the test set. Significance was assessed with the Fisher exact test, and 95% confidence intervals (CIs) were computed for sensitivity and specificity. RESULTS: A total of 386 ICVs and 67 adenomatous polyps from the training set and 102 ICVs and 138 adenomatous polyps from the test set could be segmented with a three-dimensional segmentation algorithm. When supine and prone images were counted individually, 746 nonunique ICVs from the training set and 191 from the test set were segmentable. In the training set, a volume of 600 mm super(3) and an attenuation of 36 HU provided 100% sensitivity (67 polyps; 95% CI: 93%, 100%) and the optimal 83% specificity (618 of 746 ICVs; 95% CI: 80%, 85%). When applied to the test set, this combination provided 97% sensitivity (134 of 138 polyps; 95% CI: 92%, 99%) and 84% specificity (160 of 191 ICVs; 95% CI: 78%, 89%). Differences in sensitivity and specificity in the detection of polyps between the sets were not significant. CONCLUSION: Volume and average CT attenuation thresholds can help differentiate most ICVs from true polyps. [copy ] RSNA, 2006 JF - Radiology AU - O'Connor, Stacy D AU - Summers, Ronald M AU - Yao, Jianhua AU - Pickhardt, Perry J AU - Choi, JRichard AD - Department of Radiology, National Institutes of Health, 10 Center Dr, Bldg 10, Rm 1C351, MSC 1182, Bethesda, MD 20892-1182 (S.D.O., R.M.S., J.Y.) Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 426 EP - 432 PB - Radiological Society of North America, 820 Jorie Blvd. Oak Brook Illinois 60523-2251 USA VL - 241 IS - 2 SN - 0033-8419, 0033-8419 KW - Biotechnology and Bioengineering Abstracts KW - Computed tomography KW - Segmentation KW - Algorithms KW - Image processing KW - Polyps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Real-time+interactive+MRI-guided+cardiac+surgery%3A+Aortic+valve+replacement+using+a+direct+apical+approach&rft.au=McVeigh%2C+Elliot+R%3BGuttman%2C+Michael+A%3BLederman%2C+Robert+J%3BLi%2C+Ming%3BKocaturk%2C+Ozgur%3BHunt%2C+Timothy%3BKozlov%2C+Shawn%3BHorvath%2C+Keith+A&rft.aulast=McVeigh&rft.aufirst=Elliot&rft.date=2006-11-01&rft.volume=56&rft.issue=5&rft.spage=958&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.21044 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Polyps; Computed tomography; Algorithms; Segmentation; Image processing ER - TY - JOUR T1 - Mesenchymal Stem Cell-Organized Bone Marrow Elements: An Alternative Hematopoietic Progenitor Resource AN - 19463841; 7126873 AB - Bone marrow-derived mesenchymal stem cells (BMMSCs) are multipotent postnatal stem cells that have been used for the treatment of bone defects and graft-versus-host diseases in clinics. In this study, we found that subcutaneously transplanted human BMMSCs are capable of organizing hematopoietic progenitors of recipient origin. These hematopoietic cells expressed multiple lineages of hematopoietic cell associated markers and were able to rescue lethally irradiated mice, with successful engraftment in the recipient, suggesting a potential bone marrow (BM) resource for stem cell therapies. Furthermore, we found that platelet-derived growth factor (PDGF) promotes the formation of BMMSC-generated BM niches through upregulation of {szligbeta}-catenin, implying that the PDGF pathway contributes to the formation of ectopic BM. These results indicate that the BMMSC-organized BM niche system represents a unique hematopoietic progenitor resource possessing potential clinical value. JF - Stem Cells AU - Miura, Yasuo AU - Gao, Zhigang AU - Miura, Masako AU - Seo, Byoung-Moo AU - Sonoyama, Wataru AU - Chen, WanJun AU - Gronthos, Stan AU - Zhang, Li AU - Shi, Songtao AD - National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA. Division of Immunology/Hematology, The Sidney-Kimmel Oncology Center, Johns Hopkins School of Medicine, Baltimore, Maryland, USA. Mesenchymal Stem Cell Group, Division of Haematology, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. Department of Physiology, The University of Maryland School of Medicine, Rockville, Maryland, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2428 EP - 2436 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 11 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Stem cells KW - Platelet-derived growth factor KW - Bone diseases KW - Bone marrow KW - Hemopoiesis KW - Graft-versus-host reaction KW - Mesenchyme KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19463841?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Mesenchymal+Stem+Cell-Organized+Bone+Marrow+Elements%3A+An+Alternative+Hematopoietic+Progenitor+Resource&rft.au=Miura%2C+Yasuo%3BGao%2C+Zhigang%3BMiura%2C+Masako%3BSeo%2C+Byoung-Moo%3BSonoyama%2C+Wataru%3BChen%2C+WanJun%3BGronthos%2C+Stan%3BZhang%2C+Li%3BShi%2C+Songtao&rft.aulast=Miura&rft.aufirst=Yasuo&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=2428&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Hemopoiesis; Stem cells; Bone marrow; Platelet-derived growth factor; Mesenchyme; Graft-versus-host reaction; Bone diseases ER - TY - JOUR T1 - NK Cell-Derived IFN- gamma Differentially Regulates Innate Resistance and Neutrophil Response in T Cell-Deficient Hosts Infected with Mycobacterium tuberculosis AN - 19394348; 7166875 AB - Although it is known that IFN- gamma -secreting T cells are critical for control of Mycobacterium tuberculosis infection, the contribution of IFN- gamma produced by NK cells to host resistance to the pathogen is less well understood. By using T cell-deficient RAG super(-/-) mice, we showed that M. tuberculosis stimulates NK cell-dependent IFN- gamma production in naive splenic cultures and in lungs of infected animals. More importantly, common cytokine receptor gamma -chain super(-/-)RAG super(-/-) animals deficient in NK cells, p40 super(-/-)RAG super(-/-), or anti-IFN- gamma mAb-treated RAG super(-/-) mice displayed significantly increased susceptibility to M. tuberculosis infection compared with untreated NK-sufficient RAG super(-/-) controls. Studies comparing IL-12 p40- and p35-deficient RAG super(-/-) mice indicated that IL-12 plays a more critical role in the induction of IFN- gamma -mediated antimycobacterial effector functions than IL-23 or other p40-containing IL-12 family members. The increased susceptibility of IL-12-deficient or anti-IFN- gamma mAb-treated RAG super(-/-) mice was associated not only with elevated bacterial loads, but also with the development of granulocyte-enriched foci in lungs. This tissue response correlated with increased expression of the granulocyte chemotactic chemokines KC and MIP-2 in NK as well as other leukocyte populations. Interestingly, depletion of granulocytes further increased bacterial burdens and exacerbated pulmonary pathology in these animals, revealing a compensatory function for neutrophils in the absence of IFN- gamma . The above observations indicate that NK cell-derived IFN- gamma differentially regulates T-independent resistance and granulocyte function in M. tuberculosis infection and suggest that this response could serve as an important barrier in AIDS patients or other individuals with compromised CD4 super(+) T cell function. JF - Journal of Immunology AU - Feng, Carl G AU - Kaviratne, Mallika AU - Rothfuchs, Antonio Gigliotti AU - Cheever, Allen AU - Hieny, Sara AU - Young, Howard A AU - Wynn, Thomas A AU - Sher, Alan AD - Immunobiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Biomedical Research Institute, Rockville, MD 20852. Laboratory of Experimental Immunology, National Cancer Institute, Center for Cancer Research, Frederick, MD 21702 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 7086 EP - 7093 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Acquired immune deficiency syndrome KW - Leukocytes (neutrophilic) KW - Natural killer cells KW - Spleen KW - Cell culture KW - Pathogens KW - Infection KW - Leukocytes (granulocytic) KW - Interleukin 12 KW - CD4 antigen KW - chemokine KC KW - Interleukin 23 KW - Lung KW - Cytokine receptors KW - Lymphocytes T KW - Tuberculosis KW - Mycobacterium tuberculosis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=NK+Cell-Derived+IFN-+gamma+Differentially+Regulates+Innate+Resistance+and+Neutrophil+Response+in+T+Cell-Deficient+Hosts+Infected+with+Mycobacterium+tuberculosis&rft.au=Feng%2C+Carl+G%3BKaviratne%2C+Mallika%3BRothfuchs%2C+Antonio+Gigliotti%3BCheever%2C+Allen%3BHieny%2C+Sara%3BYoung%2C+Howard+A%3BWynn%2C+Thomas+A%3BSher%2C+Alan&rft.aulast=Feng&rft.aufirst=Carl&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=7086&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Acquired immune deficiency syndrome; Natural killer cells; Leukocytes (neutrophilic); Spleen; Cell culture; Pathogens; Infection; Interleukin 12; Leukocytes (granulocytic); CD4 antigen; Interleukin 23; chemokine KC; Lung; Lymphocytes T; Cytokine receptors; Tuberculosis; Mycobacterium tuberculosis ER - TY - JOUR T1 - Pertussis Toxin Is Superior to TLR Ligands in Enhancing Pathogenic Autoimmunity, Targeted at a Neo-Self Antigen, by Triggering Robust Expansion of Th1 Cells and Their Cytokine Production AN - 19394320; 7166854 AB - Microbial products are assumed to play a major role in triggering pathogenic autoimmunity. Recently accumulated data have shown that these products stimulate the immune system by interacting with TLRs, expressed on APCs. To examine the capacity of various TLR ligands to trigger pathogenic autoimmunity, we used a system in which naive CD4 cells, specific against hen egg lysozyme (HEL), are injected into recipient mice expressing HEL in their eyes. Only when stimulated, the naive cells acquire pathogenic capacity and induce ocular inflammation. Seven TLR ligands were tested in this system: lipoteichoic acid/peptidoglycan, zymosan, poly (I:C), LPS, pertussis toxin (PTX), flagellin, and CpG oligodeoxynucleotide. Treatment of recipient mice with HEL alone stimulated proliferation of the transferred cells, but no disease, whereas ocular inflammation did develop in recipient mice coinjected with HEL and any one of the seven TLR ligands. Inflammation induced by PTX surpassed by its severity those induced by all other tested TLR ligands and was accompanied by a dramatic increase in number of the transferred cells that acquired features of effector Th1 lymphocytes. Ocular inflammation and number of transferred cells in recipients injected with PTX and HEL were substantially reduced by treatment with Abs against IFN- gamma or IL-12, thus indicating the role of these cytokines in the PTX effect. Overall, our observations demonstrate that various TLR ligands are capable of triggering pathogenic autoimmunity and that PTX surpasses other microbial products in this activity, by stimulating excessive proliferation and polarization toward Th1 of naive T cells. JF - Journal of Immunology AU - Fujimoto, Chiaki AU - Yu, Cheng-Rong AU - Shi, Guangpu AU - Vistica, Barbara P AU - Wawrousek, Eric F AU - Klinman, Dennis M AU - Chan, Chi-Chao AU - Egwuagu, Charles E AU - Gery, Igal AD - Laboratory of Immunology and Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6896 EP - 6903 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 10 SN - 0022-1767, 0022-1767 KW - Toxicology Abstracts; Immunology Abstracts KW - gamma -Interferon KW - Lysozyme KW - Poly (I:C) KW - Data processing KW - Helper cells KW - Immune system KW - Autoimmunity KW - peptidoglycans KW - CpG islands KW - Polarization KW - Oligonucleotides KW - pertussis toxin KW - Inflammation KW - Lipoteichoic acid KW - Interleukin 12 KW - CD4 antigen KW - Lymphocytes T KW - Cytokines KW - Lipopolysaccharides KW - Antigen-presenting cells KW - Cell proliferation KW - Flagellin KW - X 24490:Other KW - F 06930:Autoimmunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19394320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Pertussis+Toxin+Is+Superior+to+TLR+Ligands+in+Enhancing+Pathogenic+Autoimmunity%2C+Targeted+at+a+Neo-Self+Antigen%2C+by+Triggering+Robust+Expansion+of+Th1+Cells+and+Their+Cytokine+Production&rft.au=Fujimoto%2C+Chiaki%3BYu%2C+Cheng-Rong%3BShi%2C+Guangpu%3BVistica%2C+Barbara+P%3BWawrousek%2C+Eric+F%3BKlinman%2C+Dennis+M%3BChan%2C+Chi-Chao%3BEgwuagu%2C+Charles+E%3BGery%2C+Igal&rft.aulast=Fujimoto&rft.aufirst=Chiaki&rft.date=2006-11-01&rft.volume=177&rft.issue=10&rft.spage=6896&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Lysozyme; gamma -Interferon; Data processing; Poly (I:C); Immune system; Helper cells; peptidoglycans; Autoimmunity; CpG islands; Polarization; Oligonucleotides; Inflammation; pertussis toxin; Lipoteichoic acid; Interleukin 12; CD4 antigen; Lymphocytes T; Lipopolysaccharides; Cytokines; Antigen-presenting cells; Cell proliferation; Flagellin ER - TY - JOUR T1 - Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells AN - 19393808; 7147837 AB - Chronic arsenic exposure of rat liver epithelial TRL1215 cells induced malignant transformation in a concentration-dependent manner. To further define the molecular events of these arsenic-transformed cells (termed CAsE cells), gene expressions associated with arsenic carcinogenesis or influenced by methylation were examined. Real-time RT-PCR showed that at carcinogenic concentrations (500 nM, and to a less extent 250 nM of arsenite), the expressions of alpha -fetoprotein (AFP), Wilm's tumor protein-1 (WT-1), c-jun, c-myc, H-ras, c-met and hepatocyte growth factor, heme oxygenase-1, superoxide dismutase-1, glutathione-S-transferase- pi and metallothionein-1 (MT) were increased between 3 to 12-fold, while expressions of insulin-like growth factor II (IGF-II) and fibroblast growth factor receptor (FGFR1) were essentially abolished. These changes were not significant at the non-carcinogenic concentration (125 nM), except for IGF-II. The positive cell-cycle regulators cyclin D1 and PCNA were overexpressed in CAsE cells, while the negative regulators p21 and p16 were suppressed. Western-blot confirmed increases in AFP, WT-1, cyclin D1 and decreases in p16 and p21 protein in CAsE cells. The CAsE cells over-expressed MT but the demethylating agent 5-aza-deoxycytidine (5-aza-dC, 2.5 mu M, 72 h) stimulated further MT expression. 5-Aza-deoxycytidine restored the loss of expression of p21 in CAsE cells to control levels, but did not restore the expression of p16, IGF-II, or FGFR1, indicating the loss of expression of these genes is due to factors other than DNA methylation changes. Overall, an intricate variety of gene expression changes occur in arsenic-induced malignant transformation of liver cells including oncogene activation and alterations in expression of genes critical to growth regulation. JF - Toxicology and Applied Pharmacology AU - Liu, J AU - Benbrahim-Tallaa, L AU - Qian, X AU - Yu, L AU - Xie, Y AU - Boos, J AU - Qu, W AU - Waalkes, M P AD - Laboratory of Comparative Carcinogenesis, NCI at NIEHS, Mail Drop F-09, Research Triangle Park, NC 27709, USA, Liu6@niehs.nih.gov Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 407 EP - 415 VL - 216 IS - 3 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Toxicology Abstracts KW - Transformation KW - Fibroblast growth factor receptors KW - Hepatocytes KW - H-Ras protein KW - alpha -fetoprotein KW - Gene expression KW - Oncogenes KW - cyclin-dependent kinase inhibitor p21 KW - DNA methylation KW - Polymerase chain reaction KW - Azacytidine KW - Insulin-like growth factor II KW - c-Myc protein KW - cyclin D1 KW - Arsenic KW - Fibroblast growth factor receptor 1 KW - Arsenite KW - Heme oxygenase (decyclizing) KW - Tumors KW - Proliferating cell nuclear antigen KW - c-Jun protein KW - Superoxide KW - Transcription factors KW - Carcinogenesis KW - Cyclin-dependent kinase inhibitor p21 KW - Hepatocyte growth factor KW - X 24310:Pharmaceuticals KW - G 07870:Mammals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393808?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Further+studies+on+aberrant+gene+expression+associated+with+arsenic-induced+malignant+transformation+in+rat+liver+TRL1215+cells&rft.au=Liu%2C+J%3BBenbrahim-Tallaa%2C+L%3BQian%2C+X%3BYu%2C+L%3BXie%2C+Y%3BBoos%2C+J%3BQu%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-11-01&rft.volume=216&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Fibroblast growth factor receptors; Hepatocytes; H-Ras protein; alpha -fetoprotein; Gene expression; Oncogenes; cyclin-dependent kinase inhibitor p21; DNA methylation; Azacytidine; Polymerase chain reaction; Insulin-like growth factor II; c-Myc protein; cyclin D1; Arsenic; Fibroblast growth factor receptor 1; Arsenite; Heme oxygenase (decyclizing); Tumors; c-Jun protein; Proliferating cell nuclear antigen; Transcription factors; Superoxide; Carcinogenesis; Cyclin-dependent kinase inhibitor p21; Hepatocyte growth factor DO - http://dx.doi.org/10.1016/j.taap.2006.06.006 ER - TY - JOUR T1 - HIV gp120-induced Interaction between CD4 and CCR5 Requires Cholesterol-rich Microenvironments Revealed by Live Cell Fluorescence Resonance Energy Transfer Imaging AN - 19393326; 7166531 AB - Binding of the human immunodeficiency virus (HIV) envelope gp120 glycoprotein to CD4 and CCR5 receptors on the plasma membrane initiates the viral entry process. Although plasma membrane cholesterol plays an important role in HIV entry, its modulating effect on the viral entry process is unclear. Using fluorescence resonance energy transfer imaging, we have provided evidence here that CD4 and CCR5 localize in different microenvironments on the surface of resting cells. Binding of the third variable region V3-containing gp120 core to CD4 and CCR5 induced association between these receptors, which could be directly monitored by fluorescence resonance energy transfer on the plasma membrane of live cells. Depletion of cholesterol from the plasma membrane abolished the gp120 core-induced associations between CD4 and CCR5, and reloading cholesterol restored the associations in live cells. Our studies suggest that, during the first step of the HIV entry process, gp120 binding alters the microenvironments of unbound CD4 and CCR5, with plasma membrane cholesterol required for the formation of the HIV entry complex. JF - Journal of Biological Chemistry AU - Yi, Ling AU - Fang, Jun AU - Isik, Nilgun AU - Chim, Jimmy AU - Jin, Tian AD - Laboratory of Immunogenetics, Twinbrook II Facility, NIAID, National Institutes of Health, Rockville, Maryland 20852 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 35446 EP - 35453 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 46 SN - 0021-9258, 0021-9258 KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - fluorescence resonance energy transfer KW - CCR5 protein KW - Glycoprotein gp120 KW - CD4 antigen KW - Envelopes KW - Cores KW - Plasma membranes KW - Cholesterol KW - imaging KW - Human immunodeficiency virus KW - Microenvironments KW - Variable region KW - V 22360:AIDS and HIV KW - W 30910:Imaging KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19393326?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=HIV+gp120-induced+Interaction+between+CD4+and+CCR5+Requires+Cholesterol-rich+Microenvironments+Revealed+by+Live+Cell+Fluorescence+Resonance+Energy+Transfer+Imaging&rft.au=Yi%2C+Ling%3BFang%2C+Jun%3BIsik%2C+Nilgun%3BChim%2C+Jimmy%3BJin%2C+Tian&rft.aulast=Yi&rft.aufirst=Ling&rft.date=2006-11-01&rft.volume=281&rft.issue=46&rft.spage=35446&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; CCR5 protein; CD4 antigen; Plasma membranes; Glycoprotein gp120; Cholesterol; fluorescence resonance energy transfer; Microenvironments; imaging; Variable region; Cores; Envelopes ER - TY - JOUR T1 - Functional Analysis of CbpA, a DnaJ Homolog and Nucleoid-associated DNA-binding Protein AN - 19391538; 7166417 AB - DnaK/Hsp70 proteins are universally conserved ATP-dependent molecular chaperones that help proteins adopt and maintain their native conformations. DnaJ/Hsp40 and GrpE are co-chaperones that assist DnaK. CbpA is an Escherichia coli DnaJ homolog. It acts as a multicopy suppressor for dnaJ mutations and functions in vitro in combination with DnaK and GrpE in protein remodeling reactions. CbpA binds nonspecifically to DNA with preference for curved DNA and is a nucleoid-associated protein. The DNA binding and co-chaperone activities of CbpA are modulated by CbpM, a small protein that binds specifically to CbpA. To identify the regions of CbpA involved in the interaction of CbpA with CbpM and those involved in DNA binding, we constructed and characterized deletion and substitution mutants of CbpA. We discovered that CbpA interacted with CbpM through its N-terminal J-domain. We found that the region C-terminal to the J-domain was required for DNA binding. Moreover, we found that the CbpM interaction, DNA binding, and co-chaperone activities were separable; some mutants were proficient in some functions and defective in others. JF - Journal of Biological Chemistry AU - Bird, Jeremy G AU - Sharma, Suveena AU - Roshwalb, Sara C AU - Hoskins, Joel R AU - Wickner, Sue AD - Laboratory of Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 34349 EP - 34356 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 45 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - HSP40 protein KW - Deletion KW - Hsp70 protein KW - DNA-binding protein KW - Escherichia coli KW - Chaperones KW - Mutation KW - J 02310:Genetics & Taxonomy KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Functional+Analysis+of+CbpA%2C+a+DnaJ+Homolog+and+Nucleoid-associated+DNA-binding+Protein&rft.au=Bird%2C+Jeremy+G%3BSharma%2C+Suveena%3BRoshwalb%2C+Sara+C%3BHoskins%2C+Joel+R%3BWickner%2C+Sue&rft.aulast=Bird&rft.aufirst=Jeremy&rft.date=2006-11-01&rft.volume=281&rft.issue=45&rft.spage=34349&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - HSP40 protein; Deletion; Hsp70 protein; DNA-binding protein; Chaperones; Mutation; Escherichia coli ER - TY - JOUR T1 - Litter production, decomposition and nutrient return of uplifted coral reef tropical forest AN - 19381656; 7148320 AB - Four habitat types in a 10-ha permanent plot of an uplifted coral reef forest in southern Taiwan were chosen and subjected to systematic litterfall related processes. Ebenaceae and Euphorbiaceae were the dominant families. The common species in the four habitats were Diospyros maritime, Ficus benjamina and Melanolepis multiglandulosa. Habitat I on the flat terrace was dominated by Bischofia javanica and Palaquium formosanum; habitat II on the ridge of exposed coral reef was dominated by Aglaia formosana and Pouteria obovata; habitat III on the sedimentary basin was dominated by Macaranga tanariu; habitat IV at the bottom of valley was dominated by Pisonia umbellifera. Litter productions, decomposition processes and nutrient returns were monitored over a 12-month period in the four habitats. Bulk litter was gathered from traps for monthly accession of litterfall. Mixed-species litter bags containing equal portions of the individual species were used to measure the decomposition constants of the leaf litter. Fresh and decomposing litters were analyzed for C, N, P, Ca, Mg, K and Na. Experimental results indicated that mean monthly litterfall in all the habitats displayed a marked seasonal pattern, with spring troughs and summer, autumn and winter peaks associated with the typhoon and monsoon seasons. The annual litterfall ranged from 6.98 to 9.13Mgha super(-) super(1)year super(-) super(1), is within but in the higher range for tropical forests. The litterfall production in habitats I and IV was significantly (pMg=N>Na>K>P>mass>C. Carbon was returned to the forest floor in the highest amount, and the next element was Ca which ranged from 196 to 324kgha super(-) super(1)year super(-) super(1). Surprisingly, the annual returns of Ca significantly exceeded those of N, and differed significantly from those of other tropical forests. JF - Forest Ecology and Management AU - Liao, J H AU - Wang, H H AU - Tsai, C C AU - Hseu, Z Y AD - National Pingtung University of Science and Technology, 1 Hseuh-Fu Road, Nei-Pu, Pingtung 91201, Taiwan, zyhseu@mail.npust.edu.tw Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 174 EP - 185 PB - Elsevier B.V. VL - 235 IS - 1-3 SN - 0378-1127, 0378-1127 KW - Ecology Abstracts; Sustainability Science Abstracts KW - Diospyros KW - Ficus benjamina KW - Litter KW - Macaranga tanarius KW - Bischofia javanica KW - Forests KW - Nutrients KW - Habitat KW - Decomposition KW - Leaf litter KW - Pisonia KW - Ebenaceae KW - Coral reefs KW - Euphorbiaceae KW - M3 1010:Issues in Sustainable Development KW - D 04060:Management and Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19381656?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Forest+Ecology+and+Management&rft.atitle=Litter+production%2C+decomposition+and+nutrient+return+of+uplifted+coral+reef+tropical+forest&rft.au=Liao%2C+J+H%3BWang%2C+H+H%3BTsai%2C+C+C%3BHseu%2C+Z+Y&rft.aulast=Liao&rft.aufirst=J&rft.date=2006-11-01&rft.volume=235&rft.issue=1-3&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Forest+Ecology+and+Management&rft.issn=03781127&rft_id=info:doi/10.1016%2Fj.foreco.2006.08.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Leaf litter; Litter; Coral reefs; Forests; Nutrients; Habitat; Decomposition; Ficus benjamina; Diospyros; Pisonia; Macaranga tanarius; Ebenaceae; Bischofia javanica; Euphorbiaceae DO - http://dx.doi.org/10.1016/j.foreco.2006.08.010 ER - TY - JOUR T1 - Molecular basis of basal cell carcinogenesis in the atomic-bomb survivor population: p53 and PTCH gene alterations AN - 19376565; 7121319 AB - Epidemiological studies suggest that UV exposure from sunlight is the major etiology for skin cancers, both melanocytic and non-melanocytic. However, the radiation-related risk for skin cancer among atomic bomb survivors of Hiroshima and Nagasaki is primarily derived from the excess risk of basal cell carcinoma (BCC), with no demonstrable excess in squamous cell carcinoma or melanoma. The BCCs in this cohort are therefore unusual in being potentially attributable to two types of radiation-UV and ionizing (IR). BCCs have been associated with PTCH and/or p53 tumor suppressor gene alterations. To investigate the roles of these genes in relation to IR and UV exposures, we analyzed both genes in BCC samples from atomic bomb survivors. We examined 47 tumors, of which 70% had non-silent base-substitution p53 mutations independent of IR or UV exposure. However, the distribution of mutation type depends on UV and/or IR exposure. For example, C-to-T transitions at CpG sites adjacent to pyrimidine-pyrimidine (PyPy) sequences were more prevalent in tumors from UV-exposed than UV-shielded body areas and CpG-mutations at non-PyPy sequences were more prevalent in tumors from UV-shielded body areas with high-IR ( greater than or equal to 1 Gy) than low-IR (<0.2 Gy) exposure. And notably, although p53 deletion-frequencies demonstrated no IR-dose associations, deletions at the PTCH locus were more frequent (79% versus 44%) in tumors with high-IR than low-IR exposure. Moreover, 60% of high-IR tumors harbored both p53 and PTCH abnormalities compared with 23% of low-IR tumors. Therefore, alteration of both genes is likely to play a role in radiation-induced basal cell carcinogenesis. JF - Carcinogenesis AU - Mizuno, Terumi AU - Tokuoka, Shoji AU - Kishikawa, Masao AU - Nakashima, Eiji AU - Mabuchi, Kiyohiko AU - Iwamoto, Keisuke S AD - Department of Radiobiology/Molecular Epidemiology Hiroshima 732-0815, Japan. Department of Epidemiology Hiroshima 732-0815, Japan. Department of Statistics at the Radiation Effects Research Foundation Hiroshima 732-0815, Japan. Nagasaki Institute for Diagnostic Pathology Isahaya, Japan. Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, 20892-1611, USA. Roy E. Coats Research Laboratories, Department of Radiation Oncology, University of California Los Angeles, CA, 90095-1714, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 2286 EP - 2294 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 11 SN - 0143-3334, 0143-3334 KW - Genetics Abstracts; Toxicology Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor suppressor genes KW - Ptch protein KW - Etiology KW - Atomic bombs KW - Skin cancer KW - squamous cell carcinoma KW - CpG islands KW - Tumors KW - p53 protein KW - Melanoma KW - Gene deletion KW - Basal cells KW - Carcinogenesis KW - Sunlight KW - Mutation KW - X 24390:Radioactive Materials KW - B 26670:Tumor Suppressors KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19376565?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Molecular+basis+of+basal+cell+carcinogenesis+in+the+atomic-bomb+survivor+population%3A+p53+and+PTCH+gene+alterations&rft.au=Mizuno%2C+Terumi%3BTokuoka%2C+Shoji%3BKishikawa%2C+Masao%3BNakashima%2C+Eiji%3BMabuchi%2C+Kiyohiko%3BIwamoto%2C+Keisuke+S&rft.aulast=Mizuno&rft.aufirst=Terumi&rft.date=2006-11-01&rft.volume=27&rft.issue=11&rft.spage=2286&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ptch protein; Tumor suppressor genes; Etiology; Atomic bombs; Skin cancer; squamous cell carcinoma; Tumors; CpG islands; Melanoma; p53 protein; Basal cells; Gene deletion; Carcinogenesis; Sunlight; Mutation ER - TY - JOUR T1 - Possible Therapeutic Vaccine Strategy against Human Immunodeficiency Virus Escape from Reverse Transcriptase Inhibitors Studied in HLA-A2 Transgenic Mice AN - 19367468; 7125109 AB - Mutation of human immunodeficiency virus (HIV) leading to escape from anti-HIV drugs is the greatest challenge to the treatment of HIV infection. High-grade resistance to the nucleoside reverse transcriptase (RT) inhibitor lamivudine (also known as 3TC) is associated with a substitution of valine for methionine at position 184 of RT. This amino acid residue is contained within the HLA-A2-restricted epitope VIYQYMDDL (RT-WT). Here, we sought to determine whether a peptide vaccine could be developed using an epitope enhancement strategy that could induce a cytotoxic T-lymphocyte (CTL) response specific for an epitope containing the drug resistance mutation M184V to exert an opposing selective pressure. RT-WT-specific CTLs developed from HLA-A2 transgenic mice did not recognize the M184V mutation of RT-WT (RT-M184V). However, RT-M184V exhibited higher binding affinity for HLA-A2 than RT-WT. Also, both anchor-enhanced RT-WT (RT-2L9V) and RT-2L9V-M184V-specific CTLs recognized RT-M184V and displayed cross-reactivity to RT-WT. Nevertheless, the CTL repertoire elicited by the epitope-enhanced RT-2L9V-M184V appeared more selective for the RT inhibitor-induced M184V mutation. Peptide vaccines based on such strategies may be worth testing for their ability to exert selective pressure against drug-resistant strains and thus delay or prevent the development of HIV with the M184V resistance mutation. JF - Journal of Virology AU - Okazaki, Takahiro AU - Terabe, Masaki AU - Catanzaro, Andrew T AU - Pendleton, CDavid AU - Yarchoan, Robert AU - Berzofsky, Jay A AD - Vaccine Branch. HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1578 Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10645 EP - 10651 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 21 SN - 0022-538X, 0022-538X KW - HIV KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Histocompatibility antigen HLA KW - Amino acid substitution KW - Cross-reactivity KW - Lamivudine KW - Lymphocytes T KW - RNA-directed DNA polymerase KW - Amino acids KW - valine KW - Vaccines KW - Mutation KW - Drug resistance KW - Infection KW - Methionine KW - Epitopes KW - Transgenic mice KW - Cytotoxicity KW - Human immunodeficiency virus KW - nucleosides KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Possible+Therapeutic+Vaccine+Strategy+against+Human+Immunodeficiency+Virus+Escape+from+Reverse+Transcriptase+Inhibitors+Studied+in+HLA-A2+Transgenic+Mice&rft.au=Okazaki%2C+Takahiro%3BTerabe%2C+Masaki%3BCatanzaro%2C+Andrew+T%3BPendleton%2C+CDavid%3BYarchoan%2C+Robert%3BBerzofsky%2C+Jay+A&rft.aulast=Okazaki&rft.aufirst=Takahiro&rft.date=2006-11-01&rft.volume=80&rft.issue=21&rft.spage=10645&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus; Cytotoxicity; Lymphocytes T; Mutation; Histocompatibility antigen HLA; Vaccines; Epitopes; Transgenic mice; Drug resistance; RNA-directed DNA polymerase; Cross-reactivity; Amino acids; Amino acid substitution; Lamivudine; nucleosides; valine; Infection; Methionine ER - TY - JOUR T1 - Nonsegmented Negative-Strand Viruses as Vaccine Vectors AN - 19364287; 7125076 JF - Journal of Virology AU - Bukreyev, Alexander AU - Skiadopoulos, Mario H AU - Murphy, Brian R AU - Collins, Peter L AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11/01/ PY - 2006 DA - 2006 Nov 01 SP - 10293 EP - 10306 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 21 SN - 0022-538X, 0022-538X KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts KW - Vaccines KW - F 06905:Vaccines KW - V 22350:Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19364287?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Nonsegmented+Negative-Strand+Viruses+as+Vaccine+Vectors&rft.au=Bukreyev%2C+Alexander%3BSkiadopoulos%2C+Mario+H%3BMurphy%2C+Brian+R%3BCollins%2C+Peter+L&rft.aulast=Bukreyev&rft.aufirst=Alexander&rft.date=2006-11-01&rft.volume=80&rft.issue=21&rft.spage=10293&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Vaccines ER - TY - JOUR T1 - Patterns in food intake correlate with body mass index AN - 19359634; 7119719 AB - Quantifying eating behavior may give clues to both the physiological and behavioral mechanisms behind weight regulation. We analyzed year-long dietary records of 29 stable-weight subjects. The records showed wide daily variations of food intake. We computed the temporal autocorrelation and skewness of food intake mass, energy, carbohydrate, fat, and protein. We also computed the cross-correlation coefficient between intake mass and intake energy. The mass of the food intake exhibited long-term trends that were positively skewed, with wide variability among individuals. The average duration of the trends (P = 0.003) and the skewness (P = 0.006) of the food intake mass were significantly correlated with mean body mass index (BMI). We also found that the lower the correlation coefficient between the energy content and the mass of food intake, the higher the BMI. Our results imply that humans in neutral energy balance eating ad libitum exhibit a long-term positive bias in the food intake that operates partially through the mass of food eaten to defend against eating too little more vigorously than eating too much. JF - American Journal of Physiology: Endocrinology and Metabolism AU - Periwal, Vipul AU - Chow, Carson C AD - Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - E929 EP - E936 PB - American Physiological Society, 9650 Rockville Pike Bethesda MD 20814-3991 USA, [mailto:webmaster@the-aps.org], [URL:http://www.the-aps.org/] VL - 291 IS - 5 SN - 0193-1849, 0193-1849 KW - Physical Education Index KW - Behavior KW - Body mass KW - Analysis KW - Physiology KW - Diet (weight control) KW - Discrimination KW - Proteins KW - Carbohydrates KW - Trends KW - Balance KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19359634?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Physiology%3A+Endocrinology+and+Metabolism&rft.atitle=Patterns+in+food+intake+correlate+with+body+mass+index&rft.au=Periwal%2C+Vipul%3BChow%2C+Carson+C&rft.aulast=Periwal&rft.aufirst=Vipul&rft.date=2006-11-01&rft.volume=291&rft.issue=5&rft.spage=E929&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Physiology%3A+Endocrinology+and+Metabolism&rft.issn=01931849&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Behavior; Analysis; Body mass; Physiology; Diet (weight control); Proteins; Discrimination; Carbohydrates; Trends; Balance ER - TY - JOUR T1 - Immunotoxicogenomics: The Potential of Genomics Technology in the Immunotoxicity Risk Assessment Process AN - 19359503; 7127069 AB - Evaluation of xenobiotic-induced changes in gene expression as a method to identify and classify potential toxicants is being pursued by industry and regulatory agencies worldwide. A workshop was held at the Research Triangle Park campus of the Environmental Protection Agency to discuss the current state-of-the-science of "immunotoxicogenomics" and to explore the potential role of genomics techniques for immunotoxicity testing. The genesis of the workshop was the current lack of widely accepted triggering criteria for Tier 1 immunotoxicity testing in the context of routine toxicity testing data, the realization that traditional screening methods would require an inordinate number of animals and are inadequate to handle the number of chemicals that may need to be screened (e.g., high production volume compounds) and the absence of an organized effort to address the state-of-the-science of toxicogenomics in the identification of immunotoxic compounds. The major focus of the meeting was on the theoretical and practical utility of genomics techniques to (1) replace or supplement current immunotoxicity screening procedures, (2) provide insight into potential modes or mechanisms of action, and (3) provide data suitable for immunotoxicity hazard identification or risk assessment. The latter goal is of considerable interest to a variety of stakeholders as a means to reduce animal use and to decrease the cost of conducting and interpreting standard toxicity tests. A number of data gaps were identified that included a lack of dose response and kinetic data for known immunotoxic compounds and a general lack of data correlating genomic alterations to functional changes observed in vivo. Participants concluded that a genomics approach to screen chemicals for immunotoxic potential or to generate data useful to risk assessors holds promise but that routine use of these methods is years in the future. However, recent progress in molecular immunology has made mode and mechanism of action studies much more practical. Furthermore, a variety of published immunotoxicity studies suggest that microarray analysis is already a practical means to explore pathway-level changes that lead to altered immune function. To help move the science of immunotoxicogenomics forward, a partnership of industry, academia, and government was suggested to address data gaps, validation, quality assurance, and protocol development. JF - Toxicological Sciences AU - Luebke, Robert W AU - Holsapple, Michael P AU - Ladics, Gregory S AU - Luster, Michael I AU - Selgrade, MaryJane AU - Smialowicz, Ralph J AU - Woolhiser, Michael R AU - Germolec, Dori R AD - Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711. International Life Sciences Institute, Health and Environmental Sciences Institute, Washington, District of Columbia 20005. DuPont Crop Genetics, Wilmington, Delaware 19880. Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505. Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan 48674. National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 22 EP - 27 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 94 IS - 1 SN - 1096-6080, 1096-6080 KW - Genetics Abstracts; Toxicology Abstracts KW - Risk assessment KW - Data processing KW - Toxicants KW - Conferences KW - Toxicity KW - Gene expression KW - Immunotoxicity KW - Quality control KW - Kinetics KW - Parks KW - Immune response KW - genomics KW - Toxicity testing KW - G 07720:Immunogenetics KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19359503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=Immunotoxicogenomics%3A+The+Potential+of+Genomics+Technology+in+the+Immunotoxicity+Risk+Assessment+Process&rft.au=Luebke%2C+Robert+W%3BHolsapple%2C+Michael+P%3BLadics%2C+Gregory+S%3BLuster%2C+Michael+I%3BSelgrade%2C+MaryJane%3BSmialowicz%2C+Ralph+J%3BWoolhiser%2C+Michael+R%3BGermolec%2C+Dori+R&rft.aulast=Luebke&rft.aufirst=Robert&rft.date=2006-11-01&rft.volume=24&rft.issue=11&rft.spage=1365&rft.isbn=&rft.btitle=&rft.title=Nature+Biotechnology&rft.issn=10870156&rft_id=info:doi/10.1038%2Fnbt1106-1365 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Data processing; Conferences; Toxicants; Toxicity; Gene expression; Immunotoxicity; Kinetics; Quality control; Parks; genomics; Immune response; Toxicity testing ER - TY - JOUR T1 - Risk factors for Mycobacterium tuberculosis in US chronic dialysis patients AN - 19289801; 7125751 AB - BACKGROUND: End-stage renal disease is known to disrupt the cell-mediated immune response that is responsible for the killing of intracellular organisms such as Mycobacterium tuberculosis. Risk factors that contribute to the development of tuberculosis (TB) disease in the US dialysis population have not been studied on a large scale. METHODS: A retrospective cohort study of TB disease in 272 024 patients in the US Renal Data System initiated on dialysis therapy between 1 April 1995 and 31 December 1999 with Medicare or Medicaid as primary payer were analysed. A total of 21 risk factors were analysed. RESULTS: Among the US population studied, there is a 1.2 and 1.6% cumulative incidence of TB in patients undergoing either peritoneal or haemodialysis, respectively. Ten risk factors for TB that proved to be statistically significant included advanced age (P < 0.001), unemployment (P < 0.001), Medicaid insurance (P < 0.001), reduced body mass index (P < 0.001), decreased serum albumin (P < 0.001), haemodialysis (P = 0.019), both Asian (P = 0.010) and Native American (P = 0.020) race, ischaemic heart disease (P = 0.032), smoking (P = 0.010), illicit drug use (P = 0.018) and anaemia (P = 0.028). TB was independently associated with increased mortality, adjusted hazard ratio (AHR) 1.42 (95% CI 1.18-1.70, P < 0.001). CONCLUSIONS: The prevalence of TB disease in the US dialysis population is low compared with worldwide rates; however, the disease is associated with increased mortality. Of the 10 significant risk factors identified, five are potentially modifiable. JF - Nephrology, Dialysis and Transplantation AU - Klote, Mary M AU - Agodoa, Lawrence Y AU - Abbott, Kevin C AD - Allergy Immunology Department, Walter Reed Army Medical Center, Washington, DC, NIDDK, NIH, Bethesda, MD, Nephrology Service, Walter Reed Army Medical Center, Washington, DC and Uniformed Services University of the Health Sciences, Bethesda, MD, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 3287 EP - 3292 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 11 SN - 0931-0509, 0931-0509 KW - Microbiology Abstracts B: Bacteriology KW - Mortality KW - Age KW - Data processing KW - Peritoneum KW - Statistical analysis KW - Anemia KW - Population studies KW - Hemodialysis KW - Smoking KW - Immune response (cell-mediated) KW - Risk factors KW - Albumin KW - Kidney KW - Tuberculosis KW - Body mass index KW - Drugs KW - Races KW - Mycobacterium tuberculosis KW - Heart diseases KW - End-stage renal disease KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19289801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nephrology%2C+Dialysis+and+Transplantation&rft.atitle=Risk+factors+for+Mycobacterium+tuberculosis+in+US+chronic+dialysis+patients&rft.au=Klote%2C+Mary+M%3BAgodoa%2C+Lawrence+Y%3BAbbott%2C+Kevin+C&rft.aulast=Klote&rft.aufirst=Mary&rft.date=2006-11-01&rft.volume=21&rft.issue=11&rft.spage=3287&rft.isbn=&rft.btitle=&rft.title=Nephrology%2C+Dialysis+and+Transplantation&rft.issn=09310509&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Mortality; Age; Data processing; Peritoneum; Anemia; Statistical analysis; Population studies; Hemodialysis; Smoking; Immune response (cell-mediated); Risk factors; Albumin; Kidney; Tuberculosis; Body mass index; Drugs; Races; End-stage renal disease; Heart diseases; Mycobacterium tuberculosis ER - TY - JOUR T1 - Transmissibility and mortality impact of epidemic and pandemic influenza, with emphasis on the unusually deadly 1951 epidemic AN - 1500756559; 19046453 AB - There are important gaps in our current understanding of the influenza virus behavior. In particular, it remains unclear why some inter-pandemic seasons are associated with unusually high mortality impact, sometimes comparable to that of pandemics. Here we compare the epidemiological patterns of the unusually deadly 1951 influenza epidemic (A/H1N1) in England and Wales and Canada with those of surrounding epidemic and pandemic seasons, in terms of overall mortality impact and transmissibility. Based on the statistical and mathematical analysis of vital statistics and morbidity epidemic curves in these two countries, we show that the 1951 epidemic was associated with both higher mortality impact and higher transmissibility than the 1957 and 1968 pandemics. Surprisingly in Liverpool, considered the 'epicenter' of the severe 1951 epidemic, the mortality impact and transmissibility even surpassed the 1918 pandemic. JF - Vaccine AU - Viboud, Cecile AU - Tam, Theresa AU - Fleming, Douglas AU - Handel, Andreas AU - Miller, Mark A AU - Simonsen, Lone AD - Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Y1 - 2006/11// PY - 2006 DA - Nov 2006 SP - 6701 EP - 6707 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 24 IS - 44 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Mortality KW - Epidemics KW - Statistics KW - British Isles, England KW - Vital statistics KW - Statistical analysis KW - British Isles, Wales KW - Morbidity KW - Influenza KW - pandemics KW - Influenza virus KW - British Isles, England, Merseyside, Liverpool KW - Vaccines KW - V 22490:Miscellaneous KW - F 06905:Vaccines KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500756559?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Transmissibility+and+mortality+impact+of+epidemic+and+pandemic+influenza%2C+with+emphasis+on+the+unusually+deadly+1951+epidemic&rft.au=Viboud%2C+Cecile%3BTam%2C+Theresa%3BFleming%2C+Douglas%3BHandel%2C+Andreas%3BMiller%2C+Mark+A%3BSimonsen%2C+Lone&rft.aulast=Viboud&rft.aufirst=Cecile&rft.date=2006-11-01&rft.volume=24&rft.issue=44&rft.spage=6701&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.067 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Influenza; Mortality; pandemics; Statistics; Epidemics; Statistical analysis; Morbidity; Vital statistics; Vaccines; Influenza virus; British Isles, England; British Isles, England, Merseyside, Liverpool; British Isles, Wales DO - http://dx.doi.org/10.1016/j.vaccine.2006.05.067 ER - TY - JOUR T1 - The role of peripheral and central sodium channels in mediating brain temperature fluctuations induced by intravenous cocaine. AN - 68983532; 16956595 AB - While cocaine's interaction with the dopamine (DA) transporter and subsequent increase in DA transmission are usually considered key factors responsible for its locomotor stimulatory and reinforcing properties, many centrally mediated physiological and psychoemotional effects of cocaine are resistant to DA receptor blockade, suggesting the importance of other non-DA mechanisms. To explore the role of cocaine's interaction with Na+ channels, rats were used to compare locomotor stimulatory and temperature (NAcc, temporal muscle and skin) effects of repeated iv injections of cocaine (1 mg/kg) with those induced by procaine (PRO 5 mg/kg), a short-acting local anesthetic with negligible effect on the DA transporter, and cocaine methiodide (COC-MET 1.31 mg/kg), a quaternary cocaine derivative that is unable to cross the blood-brain barrier. While PRO, unlike cocaine, did not induce locomotor activation, it mimicked cocaine in its ability to increase brain temperature following the initial injection and to induce biphasic, down-up fluctuations following repeated injections. This similarity suggests that both these effects of cocaine may be driven by its action on Na+ channels, a common action of both drugs. While COC-MET also did not affect locomotor activity, it shared with cocaine and PRO their ability to increase brain temperature but failed to induce temperature decreases after repeated injections. These findings point toward activation of peripheral Na+ channels as the primary mechanism of rapid excitatory effects of cocaine and inhibition of centrally located Na+ channels as the primary mechanism for transient inhibitory effects of cocaine. DA receptor blockade (SCH23390+eticlopride) fully eliminated locomotor stimulatory and temperature-increasing effects of cocaine, but its temperature-decreasing effects remained intact. Surprisingly, DA receptor blockade also altered the temperature fluctuations caused by PRO and COC-MET, suggesting that some of the central effects triggered via Na+ channels are in fact DA-dependent. Finally, repeated administration of PRO to animals that had previous cocaine experience led to conditioned locomotion and potentiated temperature-increasing effects of this drug. It appears, therefore, that, in addition to the central effects of cocaine mediated via interaction with the DA transporter and potentiation of DA uptake, interaction with peripheral and central Na+ channels is important for the initial physiological and, perhaps, affective effects of cocaine, likely contributing to the unique abuse potential of this drug. JF - Brain research AU - Kiyatkin, Eugene A AU - Brown, P Leon AD - Cellular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA. ekiyatki@intra.nida.nih.gov Y1 - 2006/10/30/ PY - 2006 DA - 2006 Oct 30 SP - 38 EP - 53 VL - 1117 IS - 1 SN - 0006-8993, 0006-8993 KW - Anesthetics, Local KW - 0 KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - Receptors, Dopamine KW - Sodium Channels KW - Procaine KW - 4Z8Y51M438 KW - cocaine methiodide KW - 5937-29-1 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Receptors, Dopamine -- drug effects KW - Animals KW - Rats, Long-Evans KW - Peripheral Nervous System -- metabolism KW - Anesthetics, Local -- pharmacology KW - Injections, Intravenous KW - Nucleus Accumbens -- drug effects KW - Dopamine Antagonists -- pharmacology KW - Muscle, Skeletal -- innervation KW - Procaine -- pharmacology KW - Blood-Brain Barrier -- physiology KW - Peripheral Nervous System -- drug effects KW - Motor Activity -- physiology KW - Nucleus Accumbens -- physiopathology KW - Muscle, Skeletal -- drug effects KW - Rats KW - Blood-Brain Barrier -- drug effects KW - Skin -- drug effects KW - Skin -- innervation KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- drug effects KW - Male KW - Receptors, Dopamine -- metabolism KW - Dopamine Uptake Inhibitors -- pharmacology KW - Body Temperature -- drug effects KW - Brain -- drug effects KW - Brain Chemistry -- drug effects KW - Sodium Channels -- metabolism KW - Brain -- metabolism KW - Brain -- physiopathology KW - Cocaine -- analogs & derivatives KW - Cocaine-Related Disorders -- physiopathology KW - Body Temperature -- physiology KW - Cocaine -- pharmacology KW - Cocaine-Related Disorders -- metabolism KW - Sodium Channels -- drug effects KW - Brain Chemistry -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68983532?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=The+role+of+peripheral+and+central+sodium+channels+in+mediating+brain+temperature+fluctuations+induced+by+intravenous+cocaine.&rft.au=Kiyatkin%2C+Eugene+A%3BBrown%2C+P+Leon&rft.aulast=Kiyatkin&rft.aufirst=Eugene&rft.date=2006-10-30&rft.volume=1117&rft.issue=1&rft.spage=38&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Synapse. 1998 Feb;28(2):111-6 [9450511] Pharmacol Biochem Behav. 1998 Feb;59(2):305-12 [9476974] J Neurosci. 1998 Mar 15;18(6):1979-86 [9482784] J Neuropsychiatry Clin Neurosci. 1998 Spring;10(2):148-59 [9608403] Prog Biophys Mol Biol. 1973;26:147-87 [4145345] Biochem Pharmacol. 1975 Apr 15;24(8):847-52 [1125084] Am J Physiol. 1976 Feb;230(2):449-55 [816208] Psychopharmacology (Berl). 1978 Apr 14;57(1):13-20 [96463] Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):67-75 [684280] Oral Surg Oral Med Oral Pathol. 1979 Oct;48(4):292-7 [291855] Brain Res. 1983 Jan 10;258(2):217-28 [6824912] Pharmacol Biochem Behav. 1983 May;18(5):711-6 [6856646] Br J Anaesth. 1985 Oct;57(10):1006-11 [4041306] Brain Res. 1985 Dec 30;361(1-2):339-50 [4084803] J Biol Chem. 1986 Jun 5;261(16):7300-5 [2423518] Psychopharmacology (Berl). 1986;90(1):142-3 [2876452] Synapse. 2001 Jan;39(1):32-41 [11071707] Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6859-64 [11381119] Synapse. 2001 Sep 15;41(4):301-10 [11494401] Psychopharmacology (Berl). 2001 Sep;157(3):260-8 [11605081] Psychopharmacology (Berl). 2002 Jan;159(2):154-60 [11862343] Ann Intern Med. 2002 Jun 4;136(11):785-91 [12044126] J Neurophysiol. 2002 Jul;88(1):300-5 [12091555] Eur J Neurosci. 2002 Jul;16(1):164-8 [12153543] J Physiol. 2002 Dec 1;545(Pt 2):697-704 [12456844] Neuroscience. 2003;116(2):525-38 [12559108] Pharmacology. 2003 May;68(1):49-56 [12660479] J Neurosci. 2003 May 15;23(10):3959-62 [12764079] Brain Res. 2004 Apr 16;1005(1-2):101-16 [15044070] Am J Physiol. 1966 Sep;211(3):755-69 [5927906] Exp Neurol. 1967 Mar;17(3):293-312 [6019262] Am J Physiol. 1968 Aug;215(2):389-403 [4969787] Physiol Rev. 1991 Jan;71(1):155-234 [1986388] Eur J Pharmacol. 1991 Jun 6;198(2-3):203-5 [1864307] J Pharmacol Exp Ther. 1992 Nov;263(2):734-41 [1432699] J Pharmacol Exp Ther. 1992 Nov;263(2):757-61 [1359115] Brain Res. 1993 Oct 29;626(1-2):117-26 [8281422] Neurosci Lett. 1993 Dec 24;164(1-2):175-8 [8152597] J Physiol. 1994 Jan 15;474(2):233-43 [8006810] Eur J Pharmacol. 1994 Nov 3;264(3):391-8 [7698180] Life Sci. 1987 Mar 16;40(11):1099-111 [3821374] Pharmacol Biochem Behav. 1987 Feb;26(2):453-61 [3033700] Science. 1987 Sep 4;237(4819):1219-23 [2820058] Psychol Rev. 1987 Oct;94(4):469-92 [3317472] Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(4):345-64 [3423267] J Neurosci. 1988 Jan;8(1):100-12 [3339402] Int J Neurosci. 1988 Sep;42(1-2):21-43 [3209370] Psychiatry Res. 1989 Feb;27(2):117-25 [2652168] Neuropharmacology. 1989 Dec;28(12):1383-8 [2533329] NIDA Res Monogr. 1989;95:146-51 [2561820] J Pharmacol Exp Ther. 1990 Oct;255(1):154-60 [2213551] Stroke. 1990 Dec;21(12):1710-4 [2175959] Eur J Pharmacol. 1998 Dec 18;363(2-3):147-52 [9881582] J Cardiovasc Pharmacol. 1999 Jan;33(1):36-42 [9890394] Nat Neurosci. 1998 May;1(1):36-41 [10195106] Nat Neurosci. 1998 Jun;1(2):132-7 [10195128] J Neurosci. 1999 May 1;19(9):3594-609 [10212318] J Neurochem. 1999 Sep;73(3):1043-50 [10461893] Eur J Neurosci. 2004 Nov;20(10):2838-42 [15548229] Physiol Behav. 2005 Mar 31;84(4):563-70 [15811391] Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10023-8 [16006505] Eur J Neurosci. 2005 Aug;22(4):930-8 [16115216] Arch Int Pharmacodyn Ther. 1971 Jan;189(1):198-208 [5130150] Brain Res Brain Res Rev. 2005 Dec 1;50(1):27-56 [15890410] J Cereb Blood Flow Metab. 2006 Jan;26(1):68-78 [15959461] Mol Cells. 2005 Dec 31;20(3):315-24 [16404144] J Neurosci. 2006 Mar 22;26(12):3206-9 [16554471] Synapse. 1996 Dec;24(4):399-402 [10638828] Eur J Neurosci. 2000 May;12(5):1789-800 [10792456] Neuroscience. 2000;98(4):729-41 [10891616] Am J Physiol Heart Circ Physiol. 2000 Jul;279(1):H1-6 [10899035] Eur J Neurosci. 2000 Aug;12(8):2985-92 [10971639] J Pharmacol Exp Ther. 1995 Apr;273(1):128-37 [7714758] Neuroscience. 1995 Feb;64(3):599-617 [7715774] Brain Topogr. 1995 Spring;7(3):209-16 [7599020] Psychopharmacology (Berl). 1995 Jul;120(1):10-20 [7480530] Neurosci Lett. 1995 Aug 25;196(3):161-4 [7501273] Neurosci Lett. 1996 Jun 21;211(2):73-6 [8830847] Neuron. 1997 Sep;19(3):591-611 [9331351] Psychopharmacology (Berl). 1997 Sep;133(1):7-16 [9335075] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Monte Carlo Geant4 Code for Internal Dose Assessment in Nuclear Medicine T2 - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AN - 40498875; 4502935 JF - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AU - Strigari, L AU - Benassi, M AU - DAndrea, M AU - Menghi, E AU - Pressello, M C AU - dAngelo, A Y1 - 2006/10/29/ PY - 2006 DA - 2006 Oct 29 KW - Statistical analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40498875?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Nuclear+Science+Symposium%2C+Medical+Imaging+Conference+and+15th+International+Room+Temperature+Semiconductor+Detector+Workshop&rft.atitle=Monte+Carlo+Geant4+Code+for+Internal+Dose+Assessment+in+Nuclear+Medicine&rft.au=Strigari%2C+L%3BBenassi%2C+M%3BDAndrea%2C+M%3BMenghi%2C+E%3BPressello%2C+M+C%3BdAngelo%2C+A&rft.aulast=Strigari&rft.aufirst=L&rft.date=2006-10-29&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Nuclear+Science+Symposium%2C+Medical+Imaging+Conference+and+15th+International+Room+Temperature+Semiconductor+Detector+Workshop&rft.issn=&rft_id=info:doi/ L2 - http://www.nss-mic.org/2006/program/ProgramBook1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Light Decay Time/gain Shift in a LaBr(3):Ce/LYSO:Ce Phoswich Detector T2 - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AN - 40498331; 4503107 JF - 2006 Nuclear Science Symposium, Medical Imaging Conference and 15th International Room Temperature Semiconductor Detector Workshop AU - Green, M V AU - Seidel, J AU - Choyke, P AU - Xi, W. Y1 - 2006/10/29/ PY - 2006 DA - 2006 Oct 29 KW - Decay KW - Light effects KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40498331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NTP+CERHR+MON&rft.atitle=NTP-CERHR+monograph+on+the+potential+human+reproductive+and+developmental+effects+of+di+%282-ethylhexyl%29+phthalate+%28DEHP%29.&rft.au=Shelby%2C+Michael+D&rft.aulast=Shelby&rft.aufirst=Michael&rft.date=2006-11-01&rft.volume=&rft.issue=18&rft.spage=v&rft.isbn=&rft.btitle=&rft.title=NTP+CERHR+MON&rft.issn=15562271&rft_id=info:doi/ L2 - http://www.nss-mic.org/2006/program/ProgramBook1.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Laminin alpha1 chain LG4 module promotes cell attachment through syndecans and cell spreading through integrin alpha2beta1. AN - 68981260; 16945929 AB - The laminin alpha1 chain is a subunit of laminin-1, a heterotrimeric basement membrane protein. The LG4-5 module at the C terminus of laminin alpha1 contains major binding sites for heparin, sulfatide, and alpha-dystroglycan and plays a critical role in early embryonic development. We previously identified active synthetic peptides AG73 and EF-1 from the sequence of laminin alpha1 LG4 for binding to syndecan and integrin alpha2beta1, respectively. However, their activity and functional relationship within the laminin-1 and LG4 as well as the functional relation between these sites and alpha-dystroglycan binding sites in LG4 are not clear. To address these questions, we created mutant recombinant LG4 proteins containing alanine substitutions within the AG73 (M1), EF-1 (M2, M3), and alpha-dystroglycan binding sites (M4, M5) and analyzed their activities. We found that recombinant proteins rec-M1 and rec-M5, containing mutations within M1 and M5, respectively, did not bind heparin or lymphoid cell lines expressing syndecans. These results suggest that LG4 binds to heparin and syndecans through M1 and M5. Rec-M1 and rec-M5 reduced fibroblast attachment, whereas mutant rec-M2 and rec-M3 retained cell attachment activity but did not promote cell spreading. Fibroblast attachment to rec-LG4 was inhibited by heparin but not by integrin antibodies. Spreading of fibroblasts on rec-LG4 was inhibited by anti-integrin alpha2 and beta1 but not by anti-integrin alpha1 and alpha6. These results suggest that the M1 and M5 sites are necessary for cell attachment on LG4 through syndecans and that the EF-1 site is for cell spreading activity through integrin alpha2beta1. In contrast, laminin-1-mediated fibroblast attachment and spreading were not inhibited by heparin or anti-integrin alpha2. Our findings indicate that LG4 has a unique function distinct from laminin-1 and suggest that laminin alpha1 LG4-5 may also be produced by a proteolytic cleavage in certain tissues where it exerts its activity. JF - The Journal of biological chemistry AU - Hozumi, Kentaro AU - Suzuki, Nobuharu AU - Nielsen, Peter K AU - Nomizu, Motoyoshi AU - Yamada, Yoshihiko AD - Molecular Biology Section, Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, MD 20892-4370, USA. Y1 - 2006/10/27/ PY - 2006 DA - 2006 Oct 27 SP - 32929 EP - 32940 VL - 281 IS - 43 SN - 0021-9258, 0021-9258 KW - Integrin alpha2beta1 KW - 0 KW - Laminin KW - Recombinant Proteins KW - Syndecans KW - laminin A KW - 151186-83-3 KW - Heparin KW - 9005-49-6 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Epithelial Cells -- physiology KW - Humans KW - Mice KW - Binding Sites KW - Fibroblasts -- physiology KW - Mutagenesis, Site-Directed KW - Recombinant Proteins -- isolation & purification KW - Fluorescent Antibody Technique, Direct KW - Recombinant Proteins -- metabolism KW - Alanine -- metabolism KW - Cells, Cultured KW - Skin -- cytology KW - Heparin -- metabolism KW - Recombinant Proteins -- chemistry KW - Male KW - Amino Acid Substitution KW - Cell Line KW - Cell Adhesion KW - Laminin -- chemistry KW - Laminin -- metabolism KW - Syndecans -- metabolism KW - Laminin -- genetics KW - Cell Movement -- physiology KW - Integrin alpha2beta1 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68981260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Laminin+alpha1+chain+LG4+module+promotes+cell+attachment+through+syndecans+and+cell+spreading+through+integrin+alpha2beta1.&rft.au=Hozumi%2C+Kentaro%3BSuzuki%2C+Nobuharu%3BNielsen%2C+Peter+K%3BNomizu%2C+Motoyoshi%3BYamada%2C+Yoshihiko&rft.aulast=Hozumi&rft.aufirst=Kentaro&rft.date=2006-10-27&rft.volume=281&rft.issue=43&rft.spage=32929&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-10-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of MTHFR gene polymorphisms with breast cancer survival. AN - 68120626; 17069650 AB - Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, C677T and A1298C, lead to decreased enzyme activity and affect chemosensitivity of tumor cells. We investigated whether these MTHFR SNPs were associated with breast cancer survival in African-American and Caucasian women. African-American (n = 143) and Caucasian (n = 105) women, who had incident breast cancer with surgery, were recruited between 1993 and 2003 from the greater Baltimore area, Maryland, USA. Kaplan-Meier survival and multivariate Cox proportional hazards regression analyses were used to examine the relationship between MTHFR SNPs and disease-specific survival. We observed opposite effects of the MTHFR polymorphisms A1298C and C677T on breast cancer survival. Carriers of the variant allele at codon 1298 (A/C or C/C) had reduced survival when compared to homozygous carriers of the common A allele [Hazard ratio (HR) = 2.05; 95% confidence interval (CI), 1.05-4.00]. In contrast, breast cancer patients with the variant allele at codon 677 (C/T or T/T) had improved survival, albeit not statistically significant, when compared to individuals with the common C/C genotype (HR = 0.65; 95% CI, 0.31-1.35). The effects were stronger in patients with estrogen receptor-negative tumors (HR = 2.70; 95% CI, 1.17-6.23 for A/C or C/C versus A/A at codon 1298; HR = 0.36; 95% CI, 0.12-1.04 for C/T or T/T versus C/C at codon 677). Interactions between the two MTHFR genotypes and race/ethnicity on breast cancer survival were also observed (A1298C, pinteraction = 0.088; C677T, pinteraction = 0.026). We found that the MTHFR SNPs, C677T and A1298C, were associated with breast cancer survival. The variant alleles had opposite effects on disease outcome in the study population. Race/ethnicity modified the association between the two SNPs and breast cancer survival. JF - BMC cancer AU - Martin, Damali N AU - Boersma, Brenda J AU - Howe, Tiffany M AU - Goodman, Julie E AU - Mechanic, Leah E AU - Chanock, Stephen J AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, Center of Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. martinda@mail.nih.gov Y1 - 2006/10/27/ PY - 2006 DA - 2006 Oct 27 SP - 257 VL - 6 KW - Cytosine KW - 8J337D1HZY KW - Methylenetetrahydrofolate Reductase (NADPH2) KW - EC 1.5.1.20 KW - Adenine KW - JAC85A2161 KW - Thymine KW - QR26YLT7LT KW - Index Medicus KW - Genotype KW - Odds Ratio KW - Humans KW - Middle Aged KW - African Americans -- genetics KW - European Continental Ancestry Group -- genetics KW - Female KW - Survival Analysis KW - Proportional Hazards Models KW - Breast Neoplasms -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- ethnology KW - Methylenetetrahydrofolate Reductase (NADPH2) -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68120626?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+cancer&rft.atitle=Association+of+MTHFR+gene+polymorphisms+with+breast+cancer+survival.&rft.au=Martin%2C+Damali+N%3BBoersma%2C+Brenda+J%3BHowe%2C+Tiffany+M%3BGoodman%2C+Julie+E%3BMechanic%2C+Leah+E%3BChanock%2C+Stephen+J%3BAmbs%2C+Stefan&rft.aulast=Martin&rft.aufirst=Damali&rft.date=2006-10-27&rft.volume=6&rft.issue=&rft.spage=257&rft.isbn=&rft.btitle=&rft.title=BMC+cancer&rft.issn=1471-2407&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-11-07 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Br J Cancer. 2004 Jan 26;90(2):526-34 [14735204] Trends Pharmacol Sci. 2001 Apr;22(4):195-201 [11282420] Cancer Epidemiol Biomarkers Prev. 2004 Feb;13(2):190-6 [14973091] Adv Drug Deliv Rev. 2004 Apr 29;56(8):1067-84 [15094207] J Nutr. 2004 Jul;134(7):1786-92 [15226470] Breast Cancer Res. 2004;6(5):192-200 [15318924] Ann Rheum Dis. 2004 Oct;63(10):1227-31 [15361376] Annu Rev Med. 1982;33:345-54 [6805415] Cancer Detect Prev. 1985;8(1-2):71-5 [4064054] J Natl Cancer Inst. 1994 May 4;86(9):705-12 [7908990] Nat Genet. 1995 May;10(1):111-3 [7647779] Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3290-5 [9096386] Mol Genet Metab. 1998 Jul;64(3):169-72 [9719624] Am J Clin Nutr. 1999 Mar;69(3):476-81 [10075333] J Clin Oncol. 2004 Nov 15;22(22):4632-42 [15542813] Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2071-7 [15598763] Cancer Res. 2005 Feb 15;65(4):1606-14 [15735051] Atherosclerosis. 2001 Jun;156(2):409-15 [11395038] Epidemiology. 2001 Jul;12(4):420-8 [11416780] Cancer Res. 2001 Aug 15;61(16):5979-84 [11507038] Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14853-8 [11742092] Pharmacogenetics. 2002 Apr;12(3):181-2 [11927832] Pharmacogenetics. 2002 Apr;12(3):183-90 [11927833] Pharmacogenetics. 2002 Jun;12(4):339-42 [12042673] Cancer Res. 2002 Aug 1;62(15):4519-24 [12154064] Cancer Lett. 2002 Jul 8;181(1):65-71 [12430180] Int J Cancer. 2003 Jan 20;103(3):294-9 [12471611] Breast Cancer Res. 2002;4(6):R14 [12473175] J Hum Genet. 2003;48(1):1-7 [12560871] J Natl Cancer Inst. 2003 Mar 5;95(5):373-80 [12618502] Nutr Cancer. 2002;44(2):139-44 [12734059] Cancer Res. 2003 Jun 1;63(11):2820-8 [12782587] Breast Cancer Res Treat. 2003 Sep;81(2):169-72 [14572159] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Clin Cancer Res. 2005 Mar 15;11(6):2156-62 [15788661] Breast Cancer Res Treat. 2005 May;91(1):73-9 [15868433] Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):2004-8 [16103452] Cancer Epidemiol Biomarkers Prev. 2005 Dec;14(12):3015-8 [16365030] Cancer Chemother Pharmacol. 2006 Jul;58(1):1-12 [16362298] J Natl Cancer Inst. 2006 Jul 5;98(13):911-9 [16818855] Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12216-8 [10535898] Ann Oncol. 2000 Mar;11(3):373-4 [10811509] Hum Mol Genet. 2001 Mar 1;10(5):433-43 [11181567] J Natl Cancer Inst. 2004 Jan 21;96(2):134-44 [14734703] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - The Endocannabinoid System and Cardiovascular Risk Factors T2 - 2006 World Congress on Controversies in Obesity, Diabetes and Hypertension AN - 40484504; 4491487 JF - 2006 World Congress on Controversies in Obesity, Diabetes and Hypertension AU - Kunos, G Y1 - 2006/10/26/ PY - 2006 DA - 2006 Oct 26 KW - Cannabinoids KW - Cardiovascular diseases KW - Risk factors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40484504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+World+Congress+on+Controversies+in+Obesity%2C+Diabetes+and+Hypertension&rft.atitle=The+Endocannabinoid+System+and+Cardiovascular+Risk+Factors&rft.au=Kunos%2C+G&rft.aulast=Kunos&rft.aufirst=G&rft.date=2006-10-26&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+World+Congress+on+Controversies+in+Obesity%2C+Diabetes+and+Hypertension&rft.issn=&rft_id=info:doi/ L2 - http://www.codhy.com/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The American Nuclear Renaissance: Today and Tomorrow T2 - 2006 Annual Meeting and Exposition of the Geological Society of America (GSA 2006) AN - 40313839; 4404327 JF - 2006 Annual Meeting and Exposition of the Geological Society of America (GSA 2006) AU - Howard, Angelina S Y1 - 2006/10/22/ PY - 2006 DA - 2006 Oct 22 KW - USA KW - Energy resources KW - Policies KW - U 5500:Geoscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40313839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Exposition+of+the+Geological+Society+of+America+%28GSA+2006%29&rft.atitle=The+American+Nuclear+Renaissance%3A+Today+and+Tomorrow&rft.au=Howard%2C+Angelina+S&rft.aulast=Howard&rft.aufirst=Angelina&rft.date=2006-10-22&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Exposition+of+the+Geological+Society+of+America+%28GSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://gsa.confex.com/gsa/2006AM/finalprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Structure-based design of potent Grb2-SH2 domain antagonists not relying on phosphotyrosine mimics. AN - 68866419; 16945340 AB - Development of Grb2-SH2 domain antagonists is considered to be an effective and non-cytotoxic strategy to develop new antiproliferative agents because of their potential to shut down the Ras signaling pathway. We developed a concise route for the efficient synthesis of G1TE analogs on solid phase. Using this route, a series of cyclic peptides that do not rely on phosphotyrosine or its mimics were designed and synthesized based upon the phage library-derived cyclopeptide, G1TE. Considering that Gly7 plays prominent roles for G1TE binding to the Grb2-SH2 domain, we introduced different amino acids in the 7th position. The D-Ala7-containing peptide 3 demonstrates improved binding affinity by adopting favorable conformation for protein binding. This can be rationalized by molecular modeling. The optimization at the Leu2 position was also studied, and the resulting cyclopeptides exhibited remarkably improved binding affinity. Based upon these global modifications, a highly potent peptide ligand 9 was discovered with a Kd = 17 nM, evaluated by Biacore binding assay. This new analog is one of the most potent non-phosphorus-containing Grb2-SH2 antagonists reported to date. This potent peptidomimetic provides a new template for the development of non-pTyr containing Grb2-SH2 domain antagonists and acts as a chemotherapeutic lead for the treatment of erbB2-related cancer. JF - Biochemical and biophysical research communications AU - Jiang, Sheng AU - Li, Peng AU - Peach, Megan L AU - Bindu, Lakshman AU - Worthy, Karen W AU - Fisher, Robert J AU - Burke, Terrence R AU - Nicklaus, Marc AU - Roller, Peter P AD - Laboratory of Medicinal Chemistry, NCI, NIH, Frederick, MD 21702, USA. Y1 - 2006/10/20/ PY - 2006 DA - 2006 Oct 20 SP - 497 EP - 503 VL - 349 IS - 2 SN - 0006-291X, 0006-291X KW - GRB2 Adaptor Protein KW - 0 KW - Peptides KW - Phosphotyrosine KW - 21820-51-9 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - Alanine KW - OF5P57N2ZX KW - Index Medicus KW - Animals KW - Humans KW - Peptides -- chemistry KW - Mice KW - Alanine -- chemistry KW - Inhibitory Concentration 50 KW - Protein Binding KW - Protein-Tyrosine Kinases -- chemistry KW - src Homology Domains KW - Phosphotyrosine -- chemistry KW - Chemistry, Pharmaceutical -- methods KW - Drug Design KW - GRB2 Adaptor Protein -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68866419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Structure-based+design+of+potent+Grb2-SH2+domain+antagonists+not+relying+on+phosphotyrosine+mimics.&rft.au=Jiang%2C+Sheng%3BLi%2C+Peng%3BPeach%2C+Megan+L%3BBindu%2C+Lakshman%3BWorthy%2C+Karen+W%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R%3BNicklaus%2C+Marc%3BRoller%2C+Peter+P&rft.aulast=Jiang&rft.aufirst=Sheng&rft.date=2006-10-20&rft.volume=349&rft.issue=2&rft.spage=497&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-30 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prions and their partners in crime. AN - 68970486; 17051207 AB - Prions, the infectious agents of transmissible spongiform encephalopathies (TSEs), have defied full characterization for decades. The dogma has been that prions lack nucleic acids and are composed of a pathological, self-inducing form of the host's prion protein (PrP). Recent progress in propagating TSE infectivity in cell-free systems has effectively ruled out the involvement of foreign nucleic acids. However, host-derived nucleic acids or other non-PrP molecules seem to be crucial. Interactions between TSE-associated PrP and its normal counterpart are also pathologically important, so the physiological functions of normal PrP and how they might be corrupted by TSE infections have been the subject of recent research. JF - Nature AU - Caughey, Byron AU - Baron, Gerald S AD - National Institute of Allergy and Infectious Disease, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840, USA. bcaughey@nih.gov Y1 - 2006/10/19/ PY - 2006 DA - 2006 Oct 19 SP - 803 EP - 810 VL - 443 IS - 7113 KW - Glycosylphosphatidylinositols KW - 0 KW - Ligands KW - Prions KW - Copper KW - 789U1901C5 KW - Index Medicus KW - Animals KW - Humans KW - Copper -- metabolism KW - Glycosylphosphatidylinositols -- metabolism KW - Copper -- pharmacology KW - Prions -- toxicity KW - Prions -- chemistry KW - Prion Diseases -- metabolism KW - Prion Diseases -- physiopathology KW - Prion Diseases -- genetics KW - Prion Diseases -- pathology KW - Prions -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970486?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Prions+and+their+partners+in+crime.&rft.au=Caughey%2C+Byron%3BBaron%2C+Gerald+S&rft.aulast=Caughey&rft.aufirst=Byron&rft.date=2006-10-19&rft.volume=443&rft.issue=7113&rft.spage=803&rft.isbn=&rft.btitle=&rft.title=Nature&rft.issn=1476-4687&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins. AN - 68970208; 16702950 AB - The overexpression or mutation of tyrosine kinases (TKs), such as the epidermal growth factor receptor (EGFR), can lead to the development of cancer. The most common mutation of the EGFR in glioblastomas is the deletion of exons 2-7 known as the EGFRvIII. This mutant receptor cannot bind EGF but, instead, is constitutively active. The Cbl family of ubiquitin ligases (Cbl, Cbl-b, and Cbl-c) targets the activated EGFR for degradation. As the EGFRvIII is transforming, we investigated whether it could be downregulated by the Cbl proteins. The overexpression of all three Cbl proteins resulted in the ubiquitination and degradation of the EGFRvIII. As with the wild-type EGFR, the TK-binding domain and the RING finger of Cbl-b are sufficient for the downregulation of the EGFRvIII. Also, we found that Cbl-b is recruited to the EGFRvIII and inhibits the transformation of NIH 3T3 cells by the EGFRvIII. Mutation of the Cbl-binding site (Y1045F) in the EGFRvIII inhibits its ubiquitination and downregulation by Cbl-b and enhances its ability to transform. Furthermore, the EGFR TK inhibitor, AG 1478, prevents the downregulation of the EGFRvIII by the Cbl proteins and antagonizes the ability of an immunotoxin directed against the EGFRvIII to kill cells expressing this receptor. In conclusion, the EGFRvIII does not transform by escaping regulation by Cbl proteins and this activation-induced downregulation of the EGFRvIII has an important role in mediating the toxicity of anti-EGFRvIII immunotoxins. JF - Oncogene AU - Davies, G C AU - Ryan, P E AU - Rahman, L AU - Zajac-Kaye, M AU - Lipkowitz, S AD - Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4255, USA. Y1 - 2006/10/19/ PY - 2006 DA - 2006 Oct 19 SP - 6497 EP - 6509 VL - 25 IS - 49 SN - 0950-9232, 0950-9232 KW - Adaptor Proteins, Signal Transducing KW - 0 KW - Quinazolines KW - Tyrphostins KW - Ubiquitin KW - epidermal growth factor receptor VIII KW - tyrphostin AG 1478 KW - 170449-18-0 KW - Proto-Oncogene Proteins c-cbl KW - EC 2.3.2.27 KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - Cblb protein, mouse KW - EC 6.3.2.19 KW - Index Medicus KW - Animals KW - Humans KW - Protein Processing, Post-Translational KW - Mice KW - Protein Binding KW - NIH 3T3 Cells KW - Adaptor Proteins, Signal Transducing -- metabolism KW - Ubiquitin -- metabolism KW - Cell Survival -- drug effects KW - Down-Regulation KW - Transfection KW - Cells, Cultured KW - CHO Cells KW - Tyrphostins -- pharmacology KW - Cell Transformation, Neoplastic KW - Cricetinae KW - Proto-Oncogene Proteins c-cbl -- metabolism KW - Receptor, Epidermal Growth Factor -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68970208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=EGFRvIII+undergoes+activation-dependent+downregulation+mediated+by+the+Cbl+proteins.&rft.au=Davies%2C+G+C%3BRyan%2C+P+E%3BRahman%2C+L%3BZajac-Kaye%2C+M%3BLipkowitz%2C+S&rft.aulast=Davies&rft.aufirst=G&rft.date=2006-10-19&rft.volume=25&rft.issue=49&rft.spage=6497&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1999 Oct 29;274(44):31707-12 [10531381] N Engl J Med. 2005 Nov 10;353(19):2012-24 [16282176] Cancer Res. 2000 Jun 1;60(11):3081-7 [10850460] Clin Cancer Res. 2000 Jul;6(7):2835-43 [10914732] Mol Cell Biol Res Commun. 1999 Aug;2(2):111-8 [10542134] Int J Cancer. 2000 Dec 15;88(6):962-9 [11093822] Nature. 2001 May 17;411(6835):355-65 [11357143] J Biol Chem. 2001 Feb 16;276(7):5375-83 [11087732] Endocr Relat Cancer. 2001 Jun;8(2):83-96 [11397666] J Biol Chem. 2001 Jul 20;276(29):27677-84 [11375397] Ann Oncol. 2001 Jun;12(6):745-60 [11484948] Mol Cell. 2001 Nov;8(5):995-1004 [11741535] Int J Cancer. 2002 Jan 1;97(1):7-14 [11774237] EMBO J. 2002 Feb 1;21(3):303-13 [11823423] J Biol Chem. 2002 Apr 26;277(17):14635-40 [11847211] Int J Cancer. 2002 Sep 10;101(2):111-7 [12209987] Mol Biol Cell. 2003 Mar;14(3):858-70 [12631709] Gene. 2003 Apr 10;308:103-13 [12711395] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6505-10 [12734385] Cancer Cell. 2003 Jun;3(6):519-23 [12842080] J Biol Chem. 2003 Aug 1;278(31):28950-60 [12754251] Cancer Res. 2003 Oct 15;63(20):6962-70 [14583498] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15871-6 [14676326] Int J Cancer. 2004 Feb 20;108(5):643-53 [14696090] Oncogene. 2004 Aug 12;23(36):6095-104 [15221011] Oncogene. 2004 Sep 9;23(41):6967-79 [15273741] Proc Natl Acad Sci U S A. 1977 Sep;74(9):3918-21 [302945] Annu Rev Biochem. 1992;61:331-54 [1497314] Cancer Res. 1993 Jul 15;53(14):3217-20 [8391918] Oncogene. 1994 Aug;9(8):2313-20 [8036013] Proc Natl Acad Sci U S A. 1994 Aug 2;91(16):7727-31 [8052651] Cell. 1994 Sep 9;78(5):787-98 [8087846] Cancer Res. 1995 Jul 15;55(14):3140-8 [7606735] Cancer Res. 1995 Oct 1;55(19):4375-82 [7671250] Cancer Res. 1995 Dec 1;55(23):5536-9 [7585629] Cell Growth Differ. 1995 Oct;6(10):1251-9 [8845302] Oncogene. 1996 Jul 4;13(1):85-96 [8700557] Cancer Res. 1996 Sep 1;56(17):3859-61 [8752145] Cancer Res. 1996 Oct 15;56(20):4791-8 [8841000] Cancer Res. 1996 Nov 1;56(21):5079-86 [8895767] J Biol Chem. 1997 Jan 31;272(5):2927-35 [9006938] J Biol Chem. 1998 Jan 30;273(5):2817-22 [9446590] Oncogene. 1998 Mar 5;16(9):1197-207 [9528862] Oncogene. 1999 Mar 11;18(10):1855-66 [10086340] Oncogene. 1999 Jun 3;18(22):3365-75 [10362357] EMBO J. 1999 Jun 15;18(12):3348-58 [10369675] J Biol Chem. 1999 Aug 6;274(32):22151-4 [10428778] Clin Cancer Res. 2005 Feb 15;11(4):1462-6 [15746047] Mol Cell. 1999 Dec;4(6):1029-40 [10635327] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression. AN - 68966632; 17024177 AB - Hypoxia promotes genetic instability for tumor progression. Recent evidence indicates that the transcription factor HIF-1alpha impairs DNA mismatch repair, yet the role of HIF-1alpha isoform, HIF-2alpha, in tumor progression remains obscure. In pursuit of the involvement of HIF-alpha in chromosomal instability, we report here that HIF-1alpha, specifically its PAS-B, induces DNA double-strand breaks at least in part by repressing the expression of NBS1, a crucial DNA repair gene constituting the MRE11A-RAD50-NBS1 complex. Despite strong similarities between the two isoforms, HIF-2alpha fails to do so. We demonstrate that this functional distinction stems from phosphorylation of HIF-2alpha Thr-324 by protein kinase D1, which discriminates between subtle differences of the two PAS-B in amino-acid sequence, thereby precluding NBS1 repression. Hence, our findings delineate a molecular pathway that functionally distinguishes HIF-1alpha from HIF-2alpha, and arguing a unique role for HIF-1alpha in tumor progression by promoting genomic instability. JF - The EMBO journal AU - To, Kenneth K-W AU - Sedelnikova, Olga A AU - Samons, Melissa AU - Bonner, William M AU - Huang, L Eric AD - Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10/18/ PY - 2006 DA - 2006 Oct 18 SP - 4784 EP - 4794 VL - 25 IS - 20 SN - 0261-4189, 0261-4189 KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - Cell Cycle Proteins KW - HIF1A protein, human KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - Multiprotein Complexes KW - NBN protein, human KW - Neoplasm Proteins KW - Nuclear Proteins KW - endothelial PAS domain-containing protein 1 KW - Index Medicus KW - DNA Repair -- genetics KW - Animals KW - Protein Structure, Tertiary -- genetics KW - Multiprotein Complexes -- genetics KW - Phosphorylation KW - Down-Regulation -- genetics KW - Humans KW - Protein Processing, Post-Translational KW - Rabbits KW - Cell Line KW - Multiprotein Complexes -- metabolism KW - Nuclear Proteins -- genetics KW - Chromosomal Instability -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Neoplasms -- genetics KW - Cell Cycle Proteins -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- genetics KW - Cell Cycle Proteins -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- metabolism KW - Neoplasm Proteins -- genetics KW - Nuclear Proteins -- metabolism KW - Neoplasm Proteins -- metabolism KW - Gene Expression Regulation, Neoplastic -- genetics KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68966632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+EMBO+journal&rft.atitle=The+phosphorylation+status+of+PAS-B+distinguishes+HIF-1alpha+from+HIF-2alpha+in+NBS1+repression.&rft.au=To%2C+Kenneth+K-W%3BSedelnikova%2C+Olga+A%3BSamons%2C+Melissa%3BBonner%2C+William+M%3BHuang%2C+L+Eric&rft.aulast=To&rft.aufirst=Kenneth&rft.date=2006-10-18&rft.volume=25&rft.issue=20&rft.spage=4784&rft.isbn=&rft.btitle=&rft.title=The+EMBO+journal&rft.issn=02614189&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell Biol. 2003 Jan;23(1):359-69 [12482987] Mol Cell Biol. 2002 Mar;22(6):1834-43 [11865061] J Biol Chem. 2003 Apr 4;278(14):12207-13 [12519769] Mol Cell Biol. 2003 May;23(9):3265-73 [12697826] J Biol Chem. 2003 May 16;278(20):17969-76 [12637538] J Biol Chem. 2003 May 23;278(21):19286-91 [12637527] J Biol Chem. 2003 May 30;278(22):19575-8 [12639949] Nat Med. 2003 Jun;9(6):677-84 [12778166] FEBS Lett. 2003 Jul 3;546(1):81-6 [12829240] Nat Rev Cancer. 2003 Oct;3(10):721-32 [13130303] Nat Rev Drug Discov. 2003 Oct;2(10):803-11 [14526383] Mol Cell Biol. 2003 Dec;23(24):9361-74 [14645546] Nat Genet. 2003 Dec;35(4):331-40 [14608355] Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15504-9 [14668441] Curr Opin Genet Dev. 2004 Feb;14(1):81-5 [15108809] EMBO J. 2004 May 5;23(9):1949-56 [15071503] Nat Med. 2004 Aug;10(8):789-99 [15286780] Genes Dev. 2004 Sep 1;18(17):2095-107 [15314031] Mol Cell Biol. 2004 Oct;24(19):8504-18 [15367671] Cancer Res. 2004 Sep 15;64(18):6556-62 [15374968] Drug Discov Today. 2004 Oct 15;9(20):869 [15493075] Nat Rev Mol Cell Biol. 2002 May;3(5):317-27 [11988766] Cancer Cell. 2002 Apr;1(3):237-46 [12086860] Cancer Cell. 2002 Apr;1(3):247-55 [12086861] Nat Med. 2002 Jul;8(7):702-10 [12053176] Nature. 2002 Jul 18;418(6895):348-52 [12124628] FASEB J. 2002 Aug;16(10):1151-62 [12153983] J Biol Chem. 2002 Nov 1;277(44):41750-5 [12205091] Curr Biol. 2002 Oct 29;12(21):1846-51 [12419185] Nature. 2002 Nov 7;420(6911):93-8 [12422221] J Biol Chem. 1998 Mar 6;273(10):5858-68 [9488723] Cell. 1998 May 1;93(3):467-76 [9590180] Cell. 1998 May 1;93(3):477-86 [9590181] Nat Genet. 1998 Jun;19(2):179-81 [9620777] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92 [9653127] Nature. 1998 Jul 30;394(6692):485-90 [9697772] Mol Cell. 1998 Aug;2(2):259-65 [9734364] Blood. 1998 Oct 1;92(7):2260-8 [9746763] Genes Dev. 1998 Nov 1;12(21):3320-4 [9808618] Nature. 1998 Dec 17;396(6712):643-9 [9872311] J Cell Biol. 1999 Sep 6;146(5):905-16 [10477747] Mutat Res. 2005 Jan 6;569(1-2):75-85 [15603753] Cancer Res. 2005 Mar 15;65(6):2277-86 [15781641] Mol Cell. 2005 Mar 18;17(6):793-803 [15780936] Nat Med. 2005 May;11(5):538-44 [15821748] Mol Cell Biol. 2005 Jun;25(11):4565-78 [15899860] Annu Rev Biochem. 2005;74:115-28 [15952883] Mol Cell Biol. 2005 Jul;25(13):5675-86 [15964822] Cancer Cell. 2005 Aug;8(2):131-41 [16098466] Cell Cycle. 2005 Jul;4(7):881-2 [15970707] Cancer Res. 2005 Dec 15;65(24):11597-604 [16357170] Genes Dev. 2006 Mar 1;20(5):557-70 [16510872] Cell Metab. 2006 Mar;3(3):177-85 [16517405] Cell Metab. 2006 Mar;3(3):187-97 [16517406] J Biol Chem. 2000 Mar 31;275(13):9390-5 [10734083] Am J Pathol. 2000 Aug;157(2):411-21 [10934146] Curr Biol. 2000 Jul 27-Aug 10;10(15):886-95 [10959836] Nature. 2000 Nov 23;408(6811):433-9 [11100718] J Cell Biol. 2000 Dec 25;151(7):1381-90 [11134068] Cancer Res. 2000 Dec 15;60(24):7106-13 [11156418] Nat Biotechnol. 2001 Apr;19(4):348-53 [11283593] J Biol Chem. 2001 Feb 2;276(5):3550-4 [11063749] Nature. 2003 Jan 23;421(6921):436-40 [12540918] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationships of human papillomavirus type, qualitative viral load, and age with cytologic abnormality. AN - 68968802; 17047075 AB - Persistent cervical infections with carcinogenic human papillomaviruses (HPV) cause virtually all cervical cancer. Cytologic abnormalities are the manifestations of HPV infections used to identify women at risk. To compare the potential of the full range of anogenital HPV genotypes to induce cytopathic effects, we examined the influences of HPV type, viral load, and age on cytopathology among 1,222 women having a single HPV type at enrollment into a 10,000-woman population-based study in Costa Rica. Cervical specimens were tested for approximately 40 HPV types by MY09/MY11 L1 primer PCR and type-specific dot blot hybridization. Types were organized by phylogenetic species and cancer risk. PCR signal strength served as a qualitative surrogate for viral load. Overall, 24.8% [95% confidence interval (95% CI), 22.4-27.3] of single prevalent HPV infections had concurrent abnormalities (atypical squamous cells or worse) ranging from 0.0% to 80.0% based on HPV type. Noncarcinogenic alpha3/alpha15 types, although highly prevalent, uncommonly caused cytologic abnormalities (13.1%; 95% CI, 9.8-17.0). In contrast, one quarter to nearly one half of infections with a single major carcinogenic species type (alpha9/alpha11/alpha7/alpha5/alpha6) produced abnormalities. Greater abnormalities were observed with increasing qualitative viral load of carcinogenic types; fewer abnormalities were observed among older women (>54 years). A high percentage (46.2%) of detected abnormalities in women infected with HPV16 or related alpha9 types were high grade or worse, consistent with strong carcinogenicity, compared with 10.7% in women infected with alpha7 types, including HPV18, a major cause of adenocarcinoma. The lack of evident severe abnormalities associated with HPV18 and related HPV types might have implications for screening for poorly detected glandular and alpha7-related lesions. JF - Cancer research AU - Kovacic, Melinda Butsch AU - Castle, Philip E AU - Herrero, Rolando AU - Schiffman, Mark AU - Sherman, Mark E AU - Wacholder, Sholom AU - Rodriguez, Ana C AU - Hutchinson, Martha L AU - Bratti, M Concepción AU - Hildesheim, Allan AU - Morales, Jorge AU - Alfaro, Mario AU - Burk, Robert D AD - Division of Cancer Epidemiology and Genetics and Cancer Prevention Fellowship Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. kovacicm@mail.nih.gov Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 10112 EP - 10119 VL - 66 IS - 20 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Cervix Uteri -- pathology KW - Age Factors KW - Cervical Intraepithelial Neoplasia -- pathology KW - Humans KW - Viral Load KW - Uterine Cervical Neoplasms -- epidemiology KW - Adult KW - Cohort Studies KW - Cervical Intraepithelial Neoplasia -- virology KW - Cervix Uteri -- virology KW - Middle Aged KW - Costa Rica -- epidemiology KW - Uterine Cervical Neoplasms -- pathology KW - Female KW - Uterine Cervical Neoplasms -- virology KW - Papillomavirus Infections -- pathology KW - Papillomavirus Infections -- epidemiology KW - Papillomaviridae -- classification KW - Uterine Cervical Diseases -- virology KW - Uterine Cervical Diseases -- pathology KW - Papillomavirus Infections -- virology KW - Papillomaviridae -- genetics KW - Uterine Cervical Diseases -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968802?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Relationships+of+human+papillomavirus+type%2C+qualitative+viral+load%2C+and+age+with+cytologic+abnormality.&rft.au=Kovacic%2C+Melinda+Butsch%3BCastle%2C+Philip+E%3BHerrero%2C+Rolando%3BSchiffman%2C+Mark%3BSherman%2C+Mark+E%3BWacholder%2C+Sholom%3BRodriguez%2C+Ana+C%3BHutchinson%2C+Martha+L%3BBratti%2C+M+Concepci%C3%B3n%3BHildesheim%2C+Allan%3BMorales%2C+Jorge%3BAlfaro%2C+Mario%3BBurk%2C+Robert+D&rft.aulast=Kovacic&rft.aufirst=Melinda&rft.date=2006-10-15&rft.volume=66&rft.issue=20&rft.spage=10112&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. AN - 68916930; 16963468 AB - The dopamine transporter gene (SLC6A3) is a candidate gene for Parkinson's disease (PD) on the basis of its critical role in dopaminergic neurotransmission. Previously, we identified 22 SNPs in the 5' region of SLC6A3, which segregate as eight haplotypes that differ in transcriptional activity when transfected in rat dopamine-producing cells. In the present work from a case-control study size of 293 cases and 395 controls, we employed a cladistic approach to examine gene-disease association. First, we found strong evidence of balancing selection in this region, as determined by a Tajima's D statistic of 2.97 (P<0.001). Second, we found that the eight haplotypes fit into two main clades and that diplotypes of these clades were marginally associated with PD. Then, after we classified cases and controls by the number of risk alleles, accounting for the well-known 3' region VNTR polymorphism, we found that having two or more risk alleles resulted in a modest but significant increase in PD risk [odds ratio=1.58; 95% confidence interval (CI): 1.03-2.40]. Finally, we detected a significant interaction between occupational pesticide exposure in men and the number of risk alleles. Among pesticide-exposed subjects, the odds ratio for having two or more risk alleles was 5.66 (95% CI: 1.73-18.53). Thus, allelic variants in SLC6A3, which affect gene expression, are associated with PD in this population and may interact with occupational pesticide exposure to increase PD risk. JF - Human molecular genetics AU - Kelada, Samir N P AU - Checkoway, Harvey AU - Kardia, Sharon L R AU - Carlson, Christopher S AU - Costa-Mallen, Paola AU - Eaton, David L AU - Firestone, Jordan AU - Powers, Karen M AU - Swanson, Phillip D AU - Franklin, Gary M AU - Longstreth, W T AU - Weller, Terri-Smith AU - Afsharinejad, Zahra AU - Costa, Lucio G AD - Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA. keladas@mail.nih.gov Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 3055 EP - 3062 VL - 15 IS - 20 SN - 0964-6906, 0964-6906 KW - Dopamine Plasma Membrane Transport Proteins KW - 0 KW - Pesticides KW - SLC6A3 protein, human KW - Index Medicus KW - Minisatellite Repeats KW - Polymorphism, Single Nucleotide KW - 3' Flanking Region -- genetics KW - Haplotypes KW - Humans KW - Case-Control Studies KW - 5' Flanking Region -- genetics KW - Male KW - Female KW - Occupational Exposure KW - Dopamine Plasma Membrane Transport Proteins -- genetics KW - Parkinson Disease -- physiopathology KW - Genetic Predisposition to Disease KW - Parkinson Disease -- genetics KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68916930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiology&rft.atitle=CT+Colonography+with+Computer-aided+Polyp+Detection%3A+Volume+and+Attenuation+Thresholds+to+Reduce+False-Positive+Findings+Owing+to+the+Ileocecal+Valve&rft.au=O%27Connor%2C+Stacy+D%3BSummers%2C+Ronald+M%3BYao%2C+Jianhua%3BPickhardt%2C+Perry+J%3BChoi%2C+JRichard&rft.aulast=O%27Connor&rft.aufirst=Stacy&rft.date=2006-11-01&rft.volume=241&rft.issue=2&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Radiology&rft.issn=00338419&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ni(II) affects ubiquitination of core histones H2B and H2A. AN - 68880757; 16870173 AB - The molecular mechanisms of nickel-induced malignant cell transformation include effects altering the structure and covalent modifications of core histones. Previously, we found that exposure of cells to Ni(II) resulted in truncation of histones H2A and H2B and thus elimination of some modification sites. Here, we investigated the effect of Ni(II) on one such modification, ubiquitination, of histones H2B and H2A in nuclei of cultured 1HAEo- and HPL1D human lung cells. After 1-5 days of exposure, Ni(II) up to 0.25 mM stimulated mono-ubiquitination of both histones, while at higher concentrations a suppression was found. Di-ubiquitination of H2A was not affected except for a drop after 5 days at 0.5 mM Ni(II). The decrease in mono-ubiquitination coincided with the appearance of truncated H2B that lacks the K120 ubiquitination site. However, prevention of truncation did not avert the decrease of H2B ubiquitination, indicating mechanistic independence of these effects. The changes in H2B ubiquitination did not fully coincide with concurrent changes in the nuclear levels of the ubiquitin-conjugating enzymes Rad6 and UbcH6. Overall, our results suggest that dysregulation of H2B ubiquitination is a part of Ni(II) adverse effects on gene expression and DNA repair which may assist in cell transformation. JF - Experimental cell research AU - Karaczyn, Aldona A AU - Golebiowski, Filip AU - Kasprzak, Kazimierz S AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. Y1 - 2006/10/15/ PY - 2006 DA - 2006 Oct 15 SP - 3252 EP - 3259 VL - 312 IS - 17 SN - 0014-4827, 0014-4827 KW - Histones KW - 0 KW - Ubiquitin KW - Nickel KW - 7OV03QG267 KW - UBE2E1 protein, human KW - EC 2.3.2.23 KW - Ubiquitin-Conjugating Enzymes KW - Index Medicus KW - Ubiquitin-Conjugating Enzymes -- metabolism KW - Methylation -- drug effects KW - Humans KW - Lung -- cytology KW - Cell Transformation, Neoplastic -- drug effects KW - Cell Line KW - Ubiquitin -- metabolism KW - Histones -- metabolism KW - Nickel -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68880757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+cell+research&rft.atitle=Ni%28II%29+affects+ubiquitination+of+core+histones+H2B+and+H2A.&rft.au=Karaczyn%2C+Aldona+A%3BGolebiowski%2C+Filip%3BKasprzak%2C+Kazimierz+S&rft.aulast=Karaczyn&rft.aufirst=Aldona&rft.date=2006-10-15&rft.volume=312&rft.issue=17&rft.spage=3252&rft.isbn=&rft.btitle=&rft.title=Experimental+cell+research&rft.issn=00144827&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Expression of Matrix Metalloproteinases and C-Kit Protein (CD 117) in Mesenchymal Tumours of the Uterus (MTU) T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40384477; 4430669 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Corrado, G AU - Carosi, M AU - Nonno, F Del AU - Vizza, E AU - Vocaturo, G AU - Licci, S AU - Brenna, A AU - Cione, A AU - Marandino, F AU - Perrone Donnorso, R. AU - Sbiroli, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Uterus KW - Tumors KW - C-Kit protein KW - Matrix metalloproteinase KW - Mesenchyme KW - Cadmium UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40384477?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Expression+of+Matrix+Metalloproteinases+and+C-Kit+Protein+%28CD+117%29+in+Mesenchymal+Tumours+of+the+Uterus+%28MTU%29&rft.au=Corrado%2C+G%3BCarosi%2C+M%3BNonno%2C+F+Del%3BVizza%2C+E%3BVocaturo%2C+G%3BLicci%2C+S%3BBrenna%2C+A%3BCione%2C+A%3BMarandino%2C+F%3BPerrone+Donnorso%2C+R.%3BSbiroli%2C+C&rft.aulast=Corrado&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Impact of Restaging Operations for Borderline Ovarian Tumors T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40383518; 4430049 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Figueiredo, E M AU - Gioia, S M AU - Moralez, G M AU - Silva, F H AU - Santiago, E G AU - Silva Neto, E L AU - Costa, R E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40383518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Impact+of+Restaging+Operations+for+Borderline+Ovarian+Tumors&rft.au=Figueiredo%2C+E+M%3BGioia%2C+S+M%3BMoralez%2C+G+M%3BSilva%2C+F+H%3BSantiago%2C+E+G%3BSilva+Neto%2C+E+L%3BCosta%2C+R+E&rft.aulast=Figueiredo&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Analysis of Surgery for Recurrent Epithelial Ovarian Cancer after a Progression-Free Interval at Least Six Months T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40375568; 4430238 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Gioia, S M AU - Bizzo, S M AU - Lima, J M AU - Gouveia, G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Surgery KW - Ovarian cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40375568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Analysis+of+Surgery+for+Recurrent+Epithelial+Ovarian+Cancer+after+a+Progression-Free+Interval+at+Least+Six+Months&rft.au=Gioia%2C+S+M%3BBizzo%2C+S+M%3BLima%2C+J+M%3BGouveia%2C+G&rft.aulast=Gioia&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification and Characterization of Coregulated Signalling Pathways in Microdissected Serous Ovarian Tumors T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40373986; 4430315 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Birrer, M AU - Bonome, T AU - Johnson, M E AU - Donninger, H AU - Wong, K K AU - Park, D C AU - Hao, K AU - Wong, W AU - Yip, D K AU - Welch, W R AU - Berkowitz, R S AU - Mok, S C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40373986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Identification+and+Characterization+of+Coregulated+Signalling+Pathways+in+Microdissected+Serous+Ovarian+Tumors&rft.au=Birrer%2C+M%3BBonome%2C+T%3BJohnson%2C+M+E%3BDonninger%2C+H%3BWong%2C+K+K%3BPark%2C+D+C%3BHao%2C+K%3BWong%2C+W%3BYip%2C+D+K%3BWelch%2C+W+R%3BBerkowitz%2C+R+S%3BMok%2C+S+C&rft.aulast=Birrer&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Amygdala Response to Emotional Faces in Major Depression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40373473; 4419579 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mah, L AU - Wood, S E AU - Furey, M L AU - Fromm, S J AU - Pine, D S AU - Drevets, W C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Depression KW - Amygdala KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40373473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+Amygdala+Response+to+Emotional+Faces+in+Major+Depression&rft.au=Mah%2C+L%3BWood%2C+S+E%3BFurey%2C+M+L%3BFromm%2C+S+J%3BPine%2C+D+S%3BDrevets%2C+W+C&rft.aulast=Mah&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Laparoscopic Radical Hysterectomy Type III in Treatment of Locally Advanced Cervical Cancer (LACC) after Neoadjuvant Chemotherapy (NACT) T2 - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AN - 40371117; 4430440 JF - 11th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2006) AU - Vizza, E AU - Corrado, G AU - Ferretti, G AU - Canitano, S AU - Savarese, A AU - Vidiri, A AU - Costaggini, I AU - Baiocco, E AU - Sbiroli, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Chemotherapy KW - Cervical cancer KW - Radicals KW - Hysterectomy KW - Laparoscopy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371117?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.atitle=Laparoscopic+Radical+Hysterectomy+Type+III+in+Treatment+of+Locally+Advanced+Cervical+Cancer+%28LACC%29+after+Neoadjuvant+Chemotherapy+%28NACT%29&rft.au=Vizza%2C+E%3BCorrado%2C+G%3BFerretti%2C+G%3BCanitano%2C+S%3BSavarese%2C+A%3BVidiri%2C+A%3BCostaggini%2C+I%3BBaiocco%2C+E%3BSbiroli%2C+C&rft.aulast=Vizza&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+Biennial+Meeting+of+the+International+Gynecologic+Cancer+Society+%28IGCS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/igcs-11/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Glucose Metabolism in Dorsal Versus Ventral Striatum Differentiates Major Depressive Subtypes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40371108; 4419578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Drevets, W C AU - Kupfer, D AU - Bogers, W AU - Thase, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glucose metabolism KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371108?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Glucose+Metabolism+in+Dorsal+Versus+Ventral+Striatum+Differentiates+Major+Depressive+Subtypes&rft.au=Drevets%2C+W+C%3BKupfer%2C+D%3BBogers%2C+W%3BThase%2C+M&rft.aulast=Drevets&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Categorization of Linguistic and Nonlinguistic Gestures: An fMRI Study using Deaf Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40371000; 4419549 JF - 36th Annual Meeting of the Society for Neuroscience AU - Husain, F T AU - Patkin, D AU - Braun, A R AU - Kim, J AU - Thai-Van, H AU - Horwitz, B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Language KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371000?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Categorization+of+Linguistic+and+Nonlinguistic+Gestures%3A+An+fMRI+Study+using+Deaf+Volunteers&rft.au=Husain%2C+F+T%3BPatkin%2C+D%3BBraun%2C+A+R%3BKim%2C+J%3BThai-Van%2C+H%3BHorwitz%2C+B&rft.aulast=Husain&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neonatal Offspring of VIP/PHI-Deficient Female Mice Exhibit Reduced Maternal Attachment T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40368744; 4417215 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lim, M A AU - Stone, M M AU - Waschek, J A AU - Hill, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Offspring KW - Mice KW - Progeny KW - Vasoactive intestinal peptide KW - Neonates KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40368744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neonatal+Offspring+of+VIP%2FPHI-Deficient+Female+Mice+Exhibit+Reduced+Maternal+Attachment&rft.au=Lim%2C+M+A%3BStone%2C+M+M%3BWaschek%2C+J+A%3BHill%2C+J+M&rft.aulast=Lim&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Microcirculatory Response to Forepaw Stimulation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40362100; 4419198 JF - 36th Annual Meeting of the Society for Neuroscience AU - Stefanovic, B AU - Hutchinson, E AU - Koretsky, A P AU - Silva, A C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Staining KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40362100?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Microcirculatory+Response+to+Forepaw+Stimulation&rft.au=Stefanovic%2C+B%3BHutchinson%2C+E%3BKoretsky%2C+A+P%3BSilva%2C+A+C&rft.aulast=Stefanovic&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging Nicotine-Induced Brain Signal Transduction Via Arachidonic Acid in Awake Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40361201; 4419044 JF - 36th Annual Meeting of the Society for Neuroscience AU - Nguyen, H N AU - Villacreses, N E AU - Chang, L AU - Rapoport, S I Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Rats KW - Neuroimaging KW - Arachidonic acid KW - Signal transduction KW - Imaging techniques KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40361201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+Nicotine-Induced+Brain+Signal+Transduction+Via+Arachidonic+Acid+in+Awake+Rats&rft.au=Nguyen%2C+H+N%3BVillacreses%2C+N+E%3BChang%2C+L%3BRapoport%2C+S+I&rft.aulast=Nguyen&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visually Specific Versus Category-Specific Regions in it Cortex of Awake Macaques Revealed by fMRI T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40360951; 4419085 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bell, A H AU - Hadj-Bouziane, F AU - Vanduffel, W AU - Ungerleider, L G AU - Tootell, R B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Cortex KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360951?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Visually+Specific+Versus+Category-Specific+Regions+in+it+Cortex+of+Awake+Macaques+Revealed+by+fMRI&rft.au=Bell%2C+A+H%3BHadj-Bouziane%2C+F%3BVanduffel%2C+W%3BUngerleider%2C+L+G%3BTootell%2C+R+B&rft.aulast=Bell&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synchronous Activity within and between Areas V4 and Fef in Attention T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40360950; 4419380 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Gotts, S J AU - Gregoriou, G G AU - Zhou, H AU - Desimone, R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40360950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synchronous+Activity+within+and+between+Areas+V4+and+Fef+in+Attention&rft.au=Gotts%2C+S+J%3BGregoriou%2C+G+G%3BZhou%2C+H%3BDesimone%2C+R&rft.aulast=Gotts&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - UCS Expectancy and Diminution of the Unconditioned fMRI Response during Pavlovian Fear Conditioning T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40359717; 4418961 JF - 36th Annual Meeting of the Society for Neuroscience AU - Knight, D C AU - Waters, N S AU - Bendettini, P A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Expectancy KW - UCS KW - Fear conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=UCS+Expectancy+and+Diminution+of+the+Unconditioned+fMRI+Response+during+Pavlovian+Fear+Conditioning&rft.au=Knight%2C+D+C%3BWaters%2C+N+S%3BBendettini%2C+P+A&rft.aulast=Knight&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Direct Current Polarization on Human Cortico-Cortical Excitation and Inhibition T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40359018; 4419403 JF - 36th Annual Meeting of the Society for Neuroscience AU - Iyer, M B AU - Lomarev, M AU - Hallett, M AU - Wassermann, E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Polarization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Direct+Current+Polarization+on+Human+Cortico-Cortical+Excitation+and+Inhibition&rft.au=Yang%2C+Sufen%3BYang%2C+Jun%3BYang%2C+Zhengqin%3BChen%2C+Posee%3BFraser%2C+Alison%3BZhang%2C+Wei%3BPang%2C+Hao%3BGao%2C+Xi%3BWilson%2C+Belinda%3BHong%2C+Jau-Shyong%3BBlock%2C+Michelle+L&rft.aulast=Yang&rft.aufirst=Sufen&rft.date=2006-11-01&rft.volume=319&rft.issue=2&rft.spage=595&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cyclin-Dependent Kinase 5 Regulates Pain Signaling through Direct Phosphorylation of Trpv1 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358915; 4419387 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pareek, T K AU - Keller, J AU - Kesavapany, S AU - Agarwal, N AU - Kuner, R AU - Pant, H C AU - Iadarola, M J AU - Kulkarni, A B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Pain KW - Signal transduction KW - Capsaicin receptors KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358915?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cyclin-Dependent+Kinase+5+Regulates+Pain+Signaling+through+Direct+Phosphorylation+of+Trpv1&rft.au=Pareek%2C+T+K%3BKeller%2C+J%3BKesavapany%2C+S%3BAgarwal%2C+N%3BKuner%2C+R%3BPant%2C+H+C%3BIadarola%2C+M+J%3BKulkarni%2C+A+B&rft.aulast=Pareek&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expectation Selectively Enhances Discrimination of Fearful Faces T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358714; 4412079 JF - 36th Annual Meeting of the Society for Neuroscience AU - Doty, T J AU - Ingvar, M AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Discrimination KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expectation+Selectively+Enhances+Discrimination+of+Fearful+Faces&rft.au=Doty%2C+T+J%3BIngvar%2C+M%3BUngerleider%2C+L+G&rft.aulast=Doty&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rostro-Caudal Topography of 3-, 2- And 1-Phase Respiratory Rhythms Revealed by Sequential Microsectioning of the Rat Brainstem in Situ T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40358224; 4413353 JF - 36th Annual Meeting of the Society for Neuroscience AU - Smith, J C AU - Abdala, A P AU - Koizumi, H AU - Rybak, I A AU - Paton, J F R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Topography KW - Respiration KW - Rhythms KW - Brain stem KW - Metabolism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rostro-Caudal+Topography+of+3-%2C+2-+And+1-Phase+Respiratory+Rhythms+Revealed+by+Sequential+Microsectioning+of+the+Rat+Brainstem+in+Situ&rft.au=Smith%2C+J+C%3BAbdala%2C+A+P%3BKoizumi%2C+H%3BRybak%2C+I+A%3BPaton%2C+J+F+R&rft.aulast=Smith&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Predictability of Aversive Stimuli Modulates Activity in Amygdala and Ventral Striatum T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40357396; 4412200 JF - 36th Annual Meeting of the Society for Neuroscience AU - Alvarez, R P AU - Biggs, A AU - Grillon, C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Amygdala KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40357396?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Predictability+of+Aversive+Stimuli+Modulates+Activity+in+Amygdala+and+Ventral+Striatum&rft.au=Alvarez%2C+R+P%3BBiggs%2C+A%3BGrillon%2C+C&rft.aulast=Alvarez&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Focused and Divided Attention and Short-term Memory to Concurrent Auditory and Visual Information T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40357129; 4412073 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thai-Van, H AU - Smith, J F AU - Kim, J AU - Husain, F T AU - Kemeny, S AU - Braun, A R AU - Horwitz, B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Attention KW - Sensory integration KW - Short term memory KW - Visual stimuli KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40357129?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Focused+and+Divided+Attention+and+Short-term+Memory+to+Concurrent+Auditory+and+Visual+Information&rft.au=Thai-Van%2C+H%3BSmith%2C+J+F%3BKim%2C+J%3BHusain%2C+F+T%3BKemeny%2C+S%3BBraun%2C+A+R%3BHorwitz%2C+B&rft.aulast=Thai-Van&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disparity-Detection: Psychophysically Measured Task Strategy is Reflected in Neural Responses in V2 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356537; 4418944 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Nienborg, H AU - Cumming, B G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356537?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Disparity-Detection%3A+Psychophysically+Measured+Task+Strategy+is+Reflected+in+Neural+Responses+in+V2&rft.au=Nienborg%2C+H%3BCumming%2C+B+G&rft.aulast=Nienborg&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Neuronal Activity in the Pre-Botzinger Complex by Medullary Raphe Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356418; 4413366 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ptak, K AU - Zhang, R AU - Milescu, L S AU - Richerson, G B AU - Smith, J C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neuromodulation KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Further+studies+on+aberrant+gene+expression+associated+with+arsenic-induced+malignant+transformation+in+rat+liver+TRL1215+cells&rft.au=Liu%2C+J%3BBenbrahim-Tallaa%2C+L%3BQian%2C+X%3BYu%2C+L%3BXie%2C+Y%3BBoos%2C+J%3BQu%2C+W%3BWaalkes%2C+M+P&rft.aulast=Liu&rft.aufirst=J&rft.date=2006-11-01&rft.volume=216&rft.issue=3&rft.spage=407&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.06.006 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurophysiological Differences in Amygdala Activation in Response to Backwardly Masked Emotional Facial Stimuli in Major Depressive Disorder T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40356324; 4418840 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ferguson, T A AU - Furey, M AU - Fromm, S AU - Iwamoto, H AU - Williams, J AU - Ohman, A AU - Drevets, W C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Amygdala KW - Emotions KW - Depression KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurophysiological+Differences+in+Amygdala+Activation+in+Response+to+Backwardly+Masked+Emotional+Facial+Stimuli+in+Major+Depressive+Disorder&rft.au=Ferguson%2C+T+A%3BFurey%2C+M%3BFromm%2C+S%3BIwamoto%2C+H%3BWilliams%2C+J%3BOhman%2C+A%3BDrevets%2C+W+C&rft.aulast=Ferguson&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Automatic Construction and Stringent Validation of Path Models from Human fMRI Data T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355713; 4414146 JF - 36th Annual Meeting of the Society for Neuroscience AU - Stein, J L AU - Wiedholz, L M AU - Mattay, V AU - Weinberger, D R AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Models KW - Automation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355713?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Automatic+Construction+and+Stringent+Validation+of+Path+Models+from+Human+fMRI+Data&rft.au=Stein%2C+J+L%3BWiedholz%2C+L+M%3BMattay%2C+V%3BWeinberger%2C+D+R%3BMeyer-Lindenberg%2C+A&rft.aulast=Stein&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Behavioral and Electrophysiological Analysis Reveals Innate Olfactory Information in a Moth T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355343; 4417578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ong, C R AU - Stopfer, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Olfaction KW - Electrophysiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Behavioral+and+Electrophysiological+Analysis+Reveals+Innate+Olfactory+Information+in+a+Moth&rft.au=Ong%2C+C+R%3BStopfer%2C+M&rft.aulast=Ong&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Influence of a Coding NRG1 Polymorphism (rs10503929) on Brain Structure in Normal Controls and Schizophrenia Subjects T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40355023; 4414089 JF - 36th Annual Meeting of the Society for Neuroscience AU - Radulescu, E AU - Mattay, V S AU - Meyer-Lindenberg, A AU - Verchinski, B A AU - Honea, R AU - Das, S AU - Straub, R AU - Vakkalanka, R AU - Law, A J AU - Weinberger, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Schizophrenia KW - Mental disorders KW - Coding KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Influence+of+a+Coding+NRG1+Polymorphism+%28rs10503929%29+on+Brain+Structure+in+Normal+Controls+and+Schizophrenia+Subjects&rft.au=Radulescu%2C+E%3BMattay%2C+V+S%3BMeyer-Lindenberg%2C+A%3BVerchinski%2C+B+A%3BHonea%2C+R%3BDas%2C+S%3BStraub%2C+R%3BVakkalanka%2C+R%3BLaw%2C+A+J%3BWeinberger%2C+D&rft.aulast=Radulescu&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Schizophrenics and Unaffected Siblings Exhibit Altered Amygdala-cingulate Functional Connectivity during the Perceptual Processing of Emotional Stimuli T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354809; 4412091 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rasetti, R AU - Mattay, V S AU - Wiedholz, L M AU - Marenco, S AU - Hariri, A AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Siblings KW - Schizophrenia KW - Emotions KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354809?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Schizophrenics+and+Unaffected+Siblings+Exhibit+Altered+Amygdala-cingulate+Functional+Connectivity+during+the+Perceptual+Processing+of+Emotional+Stimuli&rft.au=Rasetti%2C+R%3BMattay%2C+V+S%3BWiedholz%2C+L+M%3BMarenco%2C+S%3BHariri%2C+A%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Rasetti&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - IQ Affects Prefrontal Activation during Working Memory in Patients with Schizophrenia and Healthy Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354767; 4412074 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brooke, J AU - Tan, H AU - Buckholtz, J AU - Mattay, V AU - Weickert, T AU - Weinberger, D AU - Callicott, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Intelligence KW - Schizophrenia KW - Mental disorders KW - Short term memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354767?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Transmissibility+and+mortality+impact+of+epidemic+and+pandemic+influenza%2C+with+emphasis+on+the+unusually+deadly+1951+epidemic&rft.au=Viboud%2C+Cecile%3BTam%2C+Theresa%3BFleming%2C+Douglas%3BHandel%2C+Andreas%3BMiller%2C+Mark+A%3BSimonsen%2C+Lone&rft.aulast=Viboud&rft.aufirst=Cecile&rft.date=2006-11-01&rft.volume=24&rft.issue=44&rft.spage=6701&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.067 L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association between Amygdala Hyperactivity and Prefrontal Hypoactivity and Severity of Anxiety in Generalized Social Phobia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354499; 4418966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Peschardt, K AU - Morton, J AU - Smith, B AU - Geraci, M AU - Vythilingam, M AU - Finger, E AU - Drevets, W C AU - Pine, D S AU - Blair, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Anxiety KW - Hyperactivity KW - Amygdala KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Association+between+Amygdala+Hyperactivity+and+Prefrontal+Hypoactivity+and+Severity+of+Anxiety+in+Generalized+Social+Phobia&rft.au=Peschardt%2C+K%3BMorton%2C+J%3BSmith%2C+B%3BGeraci%2C+M%3BVythilingam%2C+M%3BFinger%2C+E%3BDrevets%2C+W+C%3BPine%2C+D+S%3BBlair%2C+J+R&rft.aulast=Peschardt&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Postnatal Development and Migration of Cerebellar Stellate and Basket Cells Examined in Mice Expressing Green Fluorescent Protein under the Glutamic Acid Decarboxylase 65 Promotor T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40354143; 4418758 JF - 36th Annual Meeting of the Society for Neuroscience AU - Davis, M I AU - Lovinger, D M AU - Hassoun, A T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Glutamate decarboxylase KW - Cell migration KW - Green fluorescent protein KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Postnatal+Development+and+Migration+of+Cerebellar+Stellate+and+Basket+Cells+Examined+in+Mice+Expressing+Green+Fluorescent+Protein+under+the+Glutamic+Acid+Decarboxylase+65+Promotor&rft.au=Davis%2C+M+I%3BLovinger%2C+D+M%3BHassoun%2C+A+T&rft.aulast=Davis&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - fMRI Reveals the Impact of the CS-UCS Pairing Rate on Brain Activity during Pavlovian Fear Conditioning T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40353600; 4418960 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dunsmoor, J AU - Bandettini, P AU - Knight, D C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Functional magnetic resonance imaging KW - Fear conditioning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=fMRI+Reveals+the+Impact+of+the+CS-UCS+Pairing+Rate+on+Brain+Activity+during+Pavlovian+Fear+Conditioning&rft.au=Dunsmoor%2C+J%3BBandettini%2C+P%3BKnight%2C+D+C&rft.aulast=Dunsmoor&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Anatomical Tract-Tracing Manganese-Enhanced MRI Uptake, Transport, and Detection T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40353379; 4418320 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wu, W C AU - Simmons, J AU - Chuang, K AU - Ortiz, M AU - Koretsky, A P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40353379?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=In+Vivo+Anatomical+Tract-Tracing+Manganese-Enhanced+MRI+Uptake%2C+Transport%2C+and+Detection&rft.au=Wu%2C+W+C%3BSimmons%2C+J%3BChuang%2C+K%3BOrtiz%2C+M%3BKoretsky%2C+A+P&rft.aulast=Wu&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Changes in Cerebellar mRNA in the C57Bl/WldS Mouse T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40352946; 4418719 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tsao, J W AU - Brug, M. Van Der AU - Chatterjee, M AU - Wishart, T M AU - Gillingwater, T H AU - Cookson, M R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - MRNA KW - Cerebellum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40352946?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Changes+in+Cerebellar+mRNA+in+the+C57Bl%2FWldS+Mouse&rft.au=Tsao%2C+J+W%3BBrug%2C+M.+Van+Der%3BChatterjee%2C+M%3BWishart%2C+T+M%3BGillingwater%2C+T+H%3BCookson%2C+M+R&rft.aulast=Tsao&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Correlates of Contrast Discrimination Learning in Early Visual Cortical Areas T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351891; 4412025 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mukai, I AU - Kim, D AU - Fukunaga, M AU - Japee, S AU - Marrett, S AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Discrimination KW - Discrimination learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351891?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Correlates+of+Contrast+Discrimination+Learning+in+Early+Visual+Cortical+Areas&rft.au=Mukai%2C+I%3BKim%2C+D%3BFukunaga%2C+M%3BJapee%2C+S%3BMarrett%2C+S%3BUngerleider%2C+L+G&rft.aulast=Mukai&rft.aufirst=I&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Perception of Facial Expression Modulates Activity in Face-Responsive Regions of Amygdala and Visual Cortex: An fMRI Study in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351758; 4419365 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hadj-Bouziane, F AU - Knusten, T A AU - Bell, A H AU - Becker, J E AU - Doty, T J AU - Tootell, R B AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Perception KW - Amygdala KW - Functional magnetic resonance imaging KW - Cortex (visual) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351758?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Perception+of+Facial+Expression+Modulates+Activity+in+Face-Responsive+Regions+of+Amygdala+and+Visual+Cortex%3A+An+fMRI+Study+in+Monkeys&rft.au=Hadj-Bouziane%2C+F%3BKnusten%2C+T+A%3BBell%2C+A+H%3BBecker%2C+J+E%3BDoty%2C+T+J%3BTootell%2C+R+B%3BUngerleider%2C+L+G&rft.aulast=Hadj-Bouziane&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pro-Inflammatory Effects of Peripherally Administered Angiotensin Ii T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40351490; 4413313 JF - 36th Annual Meeting of the Society for Neuroscience AU - Benicky, J AU - Larrayoz, I AU - Pavel, J AU - Sanchez-Lemus, E AU - Strbak, V AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40351490?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Research+Priorities%3A+Tobacco+Control+Policies+to+Reduce+Tobacco+use+among+Low+SES+Women+and+Girls&rft.au=Levy%2C+Anna+T%3BMcLellan%2C+Deborah+L%3BFagan%2C+Pebbles%3BJones%2C+Wanda+K%3BKaufman%2C+Nancy+J&rft.aulast=Levy&rft.aufirst=Anna&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Visibility-Related Modulation of Neural Responses in Visual Thalamic Nuclei T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350918; 4418370 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wilke, M AU - Mueller, K M AU - Leopold, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Thalamic nuclei KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Visibility-Related+Modulation+of+Neural+Responses+in+Visual+Thalamic+Nuclei&rft.au=Wilke%2C+M%3BMueller%2C+K+M%3BLeopold%2C+D+A&rft.aulast=Wilke&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BDNF Val66Met Polymorphism Modulates Hippocampal Engagement during a Simple Declarative Memory Task in the Elderly T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40350817; 4417827 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mattay, V S AU - Murty, V AU - Sambataro, F AU - Das, S AU - Tan, H AU - Kolachana, B AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Elderly KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Geriatrics KW - Memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40350817?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BDNF+Val66Met+Polymorphism+Modulates+Hippocampal+Engagement+during+a+Simple+Declarative+Memory+Task+in+the+Elderly&rft.au=Mattay%2C+V+S%3BMurty%2C+V%3BSambataro%2C+F%3BDas%2C+S%3BTan%2C+H%3BKolachana%2C+B%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Mattay&rft.aufirst=V&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Altered Prefrontal Function in Medication-Free Parkinson's Disease during Working Memory T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349561; 4418074 JF - 36th Annual Meeting of the Society for Neuroscience AU - Padmanabhan, A AU - Wint, D P AU - Kohn, P D AU - Sarpal, D K AU - Furman, D J AU - McInerney - Leo, A AU - Meyer-Lindenberg, A AU - Lopez, G AU - Nussbaum, R AU - Berman, K F Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Short term memory KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349561?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Altered+Prefrontal+Function+in+Medication-Free+Parkinson%27s+Disease+during+Working+Memory&rft.au=Padmanabhan%2C+A%3BWint%2C+D+P%3BKohn%2C+P+D%3BSarpal%2C+D+K%3BFurman%2C+D+J%3BMcInerney+-+Leo%2C+A%3BMeyer-Lindenberg%2C+A%3BLopez%2C+G%3BNussbaum%2C+R%3BBerman%2C+K+F&rft.aulast=Padmanabhan&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Flexible Modulation of Agonist Efficacy At the Human A3 Adenosine Receptor by a Newly Synthesized Allosteric Enhancer Luf6000 and Its Analogs T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349300; 4417426 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gao, Z AU - Ye, K. AU - Mamedova, L K AU - Ijzerman, A P AU - Jacobson, K A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Allosteric properties KW - Adenosine receptors KW - Analogs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349300?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Flexible+Modulation+of+Agonist+Efficacy+At+the+Human+A3+Adenosine+Receptor+by+a+Newly+Synthesized+Allosteric+Enhancer+Luf6000+and+Its+Analogs&rft.au=Gao%2C+Z%3BYe%2C+K.%3BMamedova%2C+L+K%3BIjzerman%2C+A+P%3BJacobson%2C+K+A&rft.aulast=Gao&rft.aufirst=Z&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dopamine D2R Assessment during Cocaine Self-Administration Maintenance, Extinction, and Abstinence T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40349101; 4418487 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thanos, P K AU - Michaelides, M AU - Piyis, Y AU - Reiszel, C AU - Soria, G AU - Wang, G AU - Volkow, N D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Extinction KW - Drug self-administration KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40349101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dopamine+D2R+Assessment+during+Cocaine+Self-Administration+Maintenance%2C+Extinction%2C+and+Abstinence&rft.au=Thanos%2C+P+K%3BMichaelides%2C+M%3BPiyis%2C+Y%3BReiszel%2C+C%3BSoria%2C+G%3BWang%2C+G%3BVolkow%2C+N+D&rft.aulast=Thanos&rft.aufirst=P&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inflammatory Cytokines Regulate the Production of Axon Growth-Inhibitory Molecules by Oligodendrocytes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40348042; 4414616 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wang, H AU - Mccann, T AU - Katagiri, Y AU - Laabs, T AU - Nie, H AU - Geller, H M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cytokines KW - Inflammation KW - Oligodendrocytes KW - Axons KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inflammatory+Cytokines+Regulate+the+Production+of+Axon+Growth-Inhibitory+Molecules+by+Oligodendrocytes&rft.au=Wang%2C+H%3BMccann%2C+T%3BKatagiri%2C+Y%3BLaabs%2C+T%3BNie%2C+H%3BGeller%2C+H+M&rft.aulast=Wang&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Avalanches In Vivo T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40348017; 4414577 JF - 36th Annual Meeting of the Society for Neuroscience AU - Petermann, T AU - Lebedev, M A AU - Nicolelis, M AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Avalanches KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40348017?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=An+Analysis+of+the+Willingness+of+Cardiac+Patients+for+Referral+Treatment+from+a+Military+Medical+Center+to+Affiliated+Community+Clinics+in+Taiwan&rft.au=Ying%2C+Lai+Chao&rft.aulast=Ying&rft.aufirst=Lai&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intracellular Single Neuron Activity during Neuronal Avalanches T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347881; 4414585 JF - 36th Annual Meeting of the Society for Neuroscience AU - Falco, J J AU - Bellay, T E AU - Stewart, C V AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Avalanches KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Intracellular+Single+Neuron+Activity+during+Neuronal+Avalanches&rft.au=Falco%2C+J+J%3BBellay%2C+T+E%3BStewart%2C+C+V%3BPlenz%2C+D&rft.aulast=Falco&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GABA@@dA@Inhibition Maintains Spatial Homogeneity in the Propagation of Synchrony in Cortical Networks T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347846; 4414578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Thiagarajan, T AU - Plenz, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Oscillations KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GABA%40%40dA%40Inhibition+Maintains+Spatial+Homogeneity+in+the+Propagation+of+Synchrony+in+Cortical+Networks&rft.au=Thiagarajan%2C+T%3BPlenz%2C+D&rft.aulast=Thiagarajan&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347472; 4415886 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhang, L AU - Sun, H AU - Peoples, R W AU - Ren, H AU - Hu, X. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Residues KW - Serotonin S3 receptors KW - Arginine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=An+Interaction+Involving+an+Arginine+Residue+in+the+Cytoplasmic+Domain+of+the+5-HT3A+Receptor+Contributes+to+Receptor+Desensitization&rft.au=Zhang%2C+L%3BSun%2C+H%3BPeoples%2C+R+W%3BRen%2C+H%3BHu%2C+X.&rft.aulast=Zhang&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - [@@u18@F]sp203 is a Novel Pet Radioligand for Brain mglur5 Receptors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40347103; 4418305 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brown, A K AU - Simeon, F G AU - Liow, J AU - Zoghbi, S S AU - Gladding, R L AU - Pike, V W AU - Innis, R B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40347103?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=%5B%40%40u18%40F%5Dsp203+is+a+Novel+Pet+Radioligand+for+Brain+mglur5+Receptors&rft.au=Brown%2C+A+K%3BSimeon%2C+F+G%3BLiow%2C+J%3BZoghbi%2C+S+S%3BGladding%2C+R+L%3BPike%2C+V+W%3BInnis%2C+R+B&rft.aulast=Brown&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Rat Alpha7 Nicotinic Acetylcholine Receptor Tryptophan77 to Channels Gating and Desensitization T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40346329; 4414318 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gay, E A AU - Yakel, J L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Acetylcholine receptors (nicotinic) KW - Channel gating KW - Neurotransmitters KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346329?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Contribution+of+Rat+Alpha7+Nicotinic+Acetylcholine+Receptor+Tryptophan77+to+Channels+Gating+and+Desensitization&rft.au=Gay%2C+E+A%3BYakel%2C+J+L&rft.aulast=Gay&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trichostatin a Treatment after Disease Onset Increases Survival of Mice with Spinal Muscular Atrophy T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40346203; 4418090 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sumner, C J AU - Avila, A M AU - Burnett, B G AU - Taye, A A AU - Knight, M A AU - Di Prospero, N A AU - Fischbeck, K H Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Survival KW - Trichostatin A KW - Spinal muscular atrophy KW - Disease control KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40346203?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Trichostatin+a+Treatment+after+Disease+Onset+Increases+Survival+of+Mice+with+Spinal+Muscular+Atrophy&rft.au=Sumner%2C+C+J%3BAvila%2C+A+M%3BBurnett%2C+B+G%3BTaye%2C+A+A%3BKnight%2C+M+A%3BDi+Prospero%2C+N+A%3BFischbeck%2C+K+H&rft.aulast=Sumner&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Effects of Orbitofrontal Cortex Lesions on Cocaine Self-Administration in Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345826; 4417019 JF - 36th Annual Meeting of the Society for Neuroscience AU - Grakalic, I AU - Panlilio, L V AU - Quiroz, C AU - Schindler, C W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Lesions KW - Rats KW - Drug self-administration KW - Cortex KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345826?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.atitle=Relationship+between+Self-Medication+with+Alcohol+and+Co-Morbid+Alcohol+use+Disorders+among+Individuals+with+Mood+and+Anxiety+Disorders&rft.au=Lakins%2C+Nekisha+E%3BYi%2C+Hsiao-ye%3BYahr%2C+Harold+T%3BFalk%2C+Daniel+E&rft.aulast=Lakins&rft.aufirst=Nekisha&rft.date=2006-11-04&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cocaine-Induced Neuronal Activation in Rat Brain Detected by Dynamic Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345681; 4418495 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lu, H. AU - Xi, Z. AU - Gitajn, L AU - Rea, W AU - Scholl, C AU - Matochik, J A AU - Yang, Y AU - Stein, E A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cocaine-Induced+Neuronal+Activation+in+Rat+Brain+Detected+by+Dynamic+Manganese-Enhanced+Magnetic+Resonance+Imaging+%28MEMRI%29&rft.au=Lu%2C+H.%3BXi%2C+Z.%3BGitajn%2C+L%3BRea%2C+W%3BScholl%2C+C%3BMatochik%2C+J+A%3BYang%2C+Y%3BStein%2C+E+A&rft.aulast=Lu&rft.aufirst=H.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=134th+Annual+Meeting+and+Exposition+of+the+American+Public+Health+Association&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Promoter Specific Alterations of BDNF mRNA in Frontal Cortex of Schizophrenics: Influence of Antidepressants T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345600; 4418474 JF - 36th Annual Meeting of the Society for Neuroscience AU - Weickert, C S AU - Deep-Soboslay, A AU - Cassano, H L AU - Hyde, T M AU - Kleinman, J E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antidepressants KW - Schizophrenia KW - Promoters KW - Mental disorders KW - Cortex (frontal) KW - MRNA KW - Brain-derived neurotrophic factor KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Promoter+Specific+Alterations+of+BDNF+mRNA+in+Frontal+Cortex+of+Schizophrenics%3A+Influence+of+Antidepressants&rft.au=Weickert%2C+C+S%3BDeep-Soboslay%2C+A%3BCassano%2C+H+L%3BHyde%2C+T+M%3BKleinman%2C+J+E&rft.aulast=Weickert&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Overexpression of Human Catechol-O-Methyltransferase Transgene Impairs Cognitive but not Sensory Motor-Gating Function in Inducible Tissue-Specific Transgenic Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345510; 4416966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chen, J AU - Papaleo, F AU - Song, J AU - Liu, G AU - Stepp, B AU - Pickel, J M AU - Lipska, B K AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Transgenic mice KW - Cognitive ability KW - Catechol O-methyltransferase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Overexpression+of+Human+Catechol-O-Methyltransferase+Transgene+Impairs+Cognitive+but+not+Sensory+Motor-Gating+Function+in+Inducible+Tissue-Specific+Transgenic+Mice&rft.au=Chen%2C+J%3BPapaleo%2C+F%3BSong%2C+J%3BLiu%2C+G%3BStepp%2C+B%3BPickel%2C+J+M%3BLipska%2C+B+K%3BWeinberger%2C+D+R&rft.aulast=Chen&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Substrates Underlying Formation of an Internal Model for a Visuomotor Skill T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40345449; 4415037 JF - 36th Annual Meeting of the Society for Neuroscience AU - Webster, B R AU - Celnik, P A AU - Xu, B. AU - Loubinoux, I AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Oculomotor behavior KW - Models KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40345449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Substrates+Underlying+Formation+of+an+Internal+Model+for+a+Visuomotor+Skill&rft.au=Webster%2C+B+R%3BCelnik%2C+P+A%3BXu%2C+B.%3BLoubinoux%2C+I%3BCohen%2C+L+G&rft.aulast=Webster&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Habituation Properties of Cortical Auditory Responses in Schizophrenia Patients and Unaffected Siblings Revealed by Synthetic Aperture Magnetometry T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344981; 4415605 JF - 36th Annual Meeting of the Society for Neuroscience AU - Carver, F AU - Reynolds, C AU - Kirchberg, B AU - Mitchell-Francis, J AU - Holroyd, T AU - Egan, M AU - Weinberger, D AU - Coppola, R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Siblings KW - Schizophrenia KW - Mental disorders KW - Habituation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Habituation+Properties+of+Cortical+Auditory+Responses+in+Schizophrenia+Patients+and+Unaffected+Siblings+Revealed+by+Synthetic+Aperture+Magnetometry&rft.au=Carver%2C+F%3BReynolds%2C+C%3BKirchberg%2C+B%3BMitchell-Francis%2C+J%3BHolroyd%2C+T%3BEgan%2C+M%3BWeinberger%2C+D%3BCoppola%2C+R&rft.aulast=Carver&rft.aufirst=F&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gender Differences in Neural Processing of Facial Cues of Gonadal Steroid Status in Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344538; 4415408 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rainey, C AU - Draper, C K AU - Zink, C F AU - Chen, Q AU - Stein, J L AU - Kempf, L AU - Tong, Y AU - Swaddle, J P AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Sex KW - Sex hormones KW - Sex differences KW - Information processing KW - Steroid hormones KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344538?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Gender+Differences+in+Neural+Processing+of+Facial+Cues+of+Gonadal+Steroid+Status+in+Humans&rft.au=Rainey%2C+C%3BDraper%2C+C+K%3BZink%2C+C+F%3BChen%2C+Q%3BStein%2C+J+L%3BKempf%2C+L%3BTong%2C+Y%3BSwaddle%2C+J+P%3BMeyer-Lindenberg%2C+A&rft.aulast=Rainey&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Modulation of Ethanol Sensitivity of 5-HT3A Receptors by Interaction with the Light Chain of MAP1B T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40344430; 4415890 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dong, L AU - Miko, A AU - Lovinger, D M AU - Zhang, L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Light chains KW - Microtubule-associated protein 1B KW - Serotonin S3 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40344430?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Modulation+of+Ethanol+Sensitivity+of+5-HT3A+Receptors+by+Interaction+with+the+Light+Chain+of+MAP1B&rft.au=Dong%2C+L%3BMiko%2C+A%3BLovinger%2C+D+M%3BZhang%2C+L&rft.aulast=Dong&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - To Act or not to Act: A Systems-Level Brain Model of Inhibitory Control T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343912; 4415232 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kralik, J D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=To+Act+or+not+to+Act%3A+A+Systems-Level+Brain+Model+of+Inhibitory+Control&rft.au=Kralik%2C+J+D&rft.aulast=Kralik&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Allelic Variation in COMT Effects during a Processing Speed Task in Healthy Volunteers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343409; 4415217 DE: JF - 36th Annual Meeting of the Society for Neuroscience AU - Callicott, J H AU - Sust, S AU - Tan, H AU - Zoltick, B J AU - Mattay, V S AU - Rypma, B AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343409?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Allelic+Variation+in+COMT+Effects+during+a+Processing+Speed+Task+in+Healthy+Volunteers&rft.au=Callicott%2C+J+H%3BSust%2C+S%3BTan%2C+H%3BZoltick%2C+B+J%3BMattay%2C+V+S%3BRypma%2C+B%3BWeinberger%2C+D+R&rft.aulast=Callicott&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison between Glycinergic and GABAergic Nonreciprocal Feedback Inhibition of Rod Bipolar Cells in Rat Retina T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40343293; 4414500 JF - 36th Annual Meeting of the Society for Neuroscience AU - Diamond, J S AU - Chavez, A E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Retina KW - Feedback inhibition KW - Bipolar cells KW - G-Aminobutyric acid KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40343293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=A+Comparison+between+Glycinergic+and+GABAergic+Nonreciprocal+Feedback+Inhibition+of+Rod+Bipolar+Cells+in+Rat+Retina&rft.au=Diamond%2C+J+S%3BChavez%2C+A+E&rft.aulast=Diamond&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Contribution of Cortical Activity to Changes in Firing Rate and Pattern of Subthalamic Neurons in a Rodent Model of Parkinson's Disease T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342880; 4409659 JF - 36th Annual Meeting of the Society for Neuroscience AU - Parr-Brownlie, L C AU - Poloskey, S L AU - Bergstrom, D A AU - Gonzales, K K AU - Walters, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Animal models KW - Firing rate KW - Cortex KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Contribution+of+Cortical+Activity+to+Changes+in+Firing+Rate+and+Pattern+of+Subthalamic+Neurons+in+a+Rodent+Model+of+Parkinson%27s+Disease&rft.au=Parr-Brownlie%2C+L+C%3BPoloskey%2C+S+L%3BBergstrom%2C+D+A%3BGonzales%2C+K+K%3BWalters%2C+J+R&rft.aulast=Parr-Brownlie&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Locust Olfactory Responses to Trains of Odor Pulses Show Multiple Timing-Dependent Forms of Plasticity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342850; 4414627 JF - 36th Annual Meeting of the Society for Neuroscience AU - Joseph, J AU - Brown, S L AU - Stopfer, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Odors KW - Plasticity KW - Olfaction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342850?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Locust+Olfactory+Responses+to+Trains+of+Odor+Pulses+Show+Multiple+Timing-Dependent+Forms+of+Plasticity&rft.au=Joseph%2C+J%3BBrown%2C+S+L%3BStopfer%2C+M&rft.aulast=Joseph&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Developmental Expression of Ca@@u2+@-Permeable AMPARs Underlies Depolarization-Induced LTD (DiLTD) of Mossy Fiber T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342702; 4412833 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ho, T. AU - Pelkey, K A AU - Takamiya, K AU - Xia, J AU - Huganir, R L AU - Mcbain, C J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Long-term depression KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Developmental stages KW - Mossy fibers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342702?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Developmental+Expression+of+Ca%40%40u2%2B%40-Permeable+AMPARs+Underlies+Depolarization-Induced+LTD+%28DiLTD%29+of+Mossy+Fiber&rft.au=Ho%2C+T.%3BPelkey%2C+K+A%3BTakamiya%2C+K%3BXia%2C+J%3BHuganir%2C+R+L%3BMcbain%2C+C+J&rft.aulast=Ho&rft.aufirst=T.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inactivation of Amygdala Ameliorates Chronic Stress-Induced Cognitive Deficits and Associated Reduction in the Levels of Neurotransmitters in the Hippocampus T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342526; 4416869 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rao, B AU - Deepti, N AU - Chattarji, S AU - Raju, T R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neurotransmitters KW - Amygdala KW - Hippocampus KW - Cognitive ability KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Inactivation+of+Amygdala+Ameliorates+Chronic+Stress-Induced+Cognitive+Deficits+and+Associated+Reduction+in+the+Levels+of+Neurotransmitters+in+the+Hippocampus&rft.au=Rao%2C+B%3BDeepti%2C+N%3BChattarji%2C+S%3BRaju%2C+T+R&rft.aulast=Rao&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Imaging the Context-Sensitivity of Ventral Temporal Category Representations using High-Resolution fMRI T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40342271; 4410060 JF - 36th Annual Meeting of the Society for Neuroscience AU - Simmons, W K AU - Matlis, S AU - Bellgowan, P S AU - Bodurka, J AU - Barsalou, L W AU - Martin, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Functional magnetic resonance imaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40342271?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Imaging+the+Context-Sensitivity+of+Ventral+Temporal+Category+Representations+using+High-Resolution+fMRI&rft.au=Simmons%2C+W+K%3BMatlis%2C+S%3BBellgowan%2C+P+S%3BBodurka%2C+J%3BBarsalou%2C+L+W%3BMartin%2C+A&rft.aulast=Simmons&rft.aufirst=W&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression of Kisspeptin and GPR54 in Hypothalamic GnRH Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341988; 4409712 JF - 36th Annual Meeting of the Society for Neuroscience AU - Quaynor, S AU - Hu, L. AU - Gustofson, G L AU - Defagot, M C AU - Krsmanovic, L Z AU - Catt, K J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Kiss1 protein KW - Hypothalamus KW - Neurons KW - Gonadotropin-releasing hormone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341988?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+of+Kisspeptin+and+GPR54+in+Hypothalamic+GnRH+Neurons&rft.au=Quaynor%2C+S%3BHu%2C+L.%3BGustofson%2C+G+L%3BDefagot%2C+M+C%3BKrsmanovic%2C+L+Z%3BCatt%2C+K+J&rft.aulast=Quaynor&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ipsilateral Activation of Motor and Premotor Areas during an Isometric Wrist Force Task in Healthy Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341950; 4409700 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sehm, B S AU - Perez, M A AU - Xu, B. AU - Hidler, J AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Isometric KW - Wrist KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341950?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ipsilateral+Activation+of+Motor+and+Premotor+Areas+during+an+Isometric+Wrist+Force+Task+in+Healthy+Humans&rft.au=Sehm%2C+B+S%3BPerez%2C+M+A%3BXu%2C+B.%3BHidler%2C+J%3BCohen%2C+L+G&rft.aulast=Sehm&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Trait Variation in Attachment Predicts Ventral Striatal Activation and Prefrontal-Striatal Coupling during Exposure to Aversive Social Cues T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341528; 4415401 JF - 36th Annual Meeting of the Society for Neuroscience AU - Buckholtz, J W AU - Callicott, J H AU - Hariri, A R AU - Goldberg, T E AU - Genderson, M AU - Mattay, V S AU - Weinberger, D R AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neostriatum KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341528?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Trait+Variation+in+Attachment+Predicts+Ventral+Striatal+Activation+and+Prefrontal-Striatal+Coupling+during+Exposure+to+Aversive+Social+Cues&rft.au=Buckholtz%2C+J+W%3BCallicott%2C+J+H%3BHariri%2C+A+R%3BGoldberg%2C+T+E%3BGenderson%2C+M%3BMattay%2C+V+S%3BWeinberger%2C+D+R%3BMeyer-Lindenberg%2C+A&rft.aulast=Buckholtz&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Thought Disorder, Verbal Fluency, and Neural Activity in Schizophrenia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341359; 4415609 JF - 36th Annual Meeting of the Society for Neuroscience AU - Roe, K V AU - Sarpal, D AU - Chang, W AU - Bonner-Jackson, A AU - Goldberg, T S AU - Meyer-Lindenberg, A AU - Weinberger, D R AU - Berman, K F Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Schizophrenia KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Thought+Disorder%2C+Verbal+Fluency%2C+and+Neural+Activity+in+Schizophrenia&rft.au=Roe%2C+K+V%3BSarpal%2C+D%3BChang%2C+W%3BBonner-Jackson%2C+A%3BGoldberg%2C+T+S%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R%3BBerman%2C+K+F&rft.aulast=Roe&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BLOC-1 Complex Components Dysbindin (Dtnbp1) and MUTED Modulate Dopamine D2 Receptor Endocytosis in Human Neuroblastoma Cells and Lymphoblasts T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341318; 4415618 JF - 36th Annual Meeting of the Society for Neuroscience AU - Iizuka, Y AU - Sei, Y AU - Li, Z. AU - Weinberger, D R AU - Straub, R E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Endocytosis KW - Neuroblastoma cells KW - Lymphoblasts KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341318?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BLOC-1+Complex+Components+Dysbindin+%28Dtnbp1%29+and+MUTED+Modulate+Dopamine+D2+Receptor+Endocytosis+in+Human+Neuroblastoma+Cells+and+Lymphoblasts&rft.au=Iizuka%2C+Y%3BSei%2C+Y%3BLi%2C+Z.%3BWeinberger%2C+D+R%3BStraub%2C+R+E&rft.aulast=Iizuka&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Representation of Social Hierarchy in Humans T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40341172; 4415390 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zink, C F AU - Tong, Y AU - Stein, J L AU - Rainey, C A AU - Draper, C K AU - Kempf, L AU - Chen, Q AU - Meyer-Lindenberg, A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Social hierarchy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40341172?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Representation+of+Social+Hierarchy+in+Humans&rft.au=Zink%2C+C+F%3BTong%2C+Y%3BStein%2C+J+L%3BRainey%2C+C+A%3BDraper%2C+C+K%3BKempf%2C+L%3BChen%2C+Q%3BMeyer-Lindenberg%2C+A&rft.aulast=Zink&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genotype Effects on Serotonin Transporter Availability Measured with PET and the Radioligand DASB T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40340922; 4415224 JF - 36th Annual Meeting of the Society for Neuroscience AU - Heinz, A AU - Wrase, J AU - Smolka, M AU - Gunter, S AU - Goldman, D AU - Hu, X. AU - Reimold, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Genotypes KW - Serotonin transporter KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340922?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Genotype+Effects+on+Serotonin+Transporter+Availability+Measured+with+PET+and+the+Radioligand+DASB&rft.au=Heinz%2C+A%3BWrase%2C+J%3BSmolka%2C+M%3BGunter%2C+S%3BGoldman%2C+D%3BHu%2C+X.%3BReimold%2C+M&rft.aulast=Heinz&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymorphisms in Dopamine Regulating Genes Modulate Cingulate Activity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40340519; 4415209 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wabnitz, A M AU - Mattay, V S AU - Blasi, G AU - Weickert, T AU - Kolachana, B AU - Das, S AU - Callicott, J H AU - Meyer-Lindenberg, A AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Gene polymorphism KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40340519?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Polymorphisms+in+Dopamine+Regulating+Genes+Modulate+Cingulate+Activity&rft.au=Wabnitz%2C+A+M%3BMattay%2C+V+S%3BBlasi%2C+G%3BWeickert%2C+T%3BKolachana%2C+B%3BDas%2C+S%3BCallicott%2C+J+H%3BMeyer-Lindenberg%2C+A%3BWeinberger%2C+D+R&rft.aulast=Wabnitz&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - @@u125@I a-Bungarotoxin Binding Sites within the Human Dorsolateral Prefrontal Cortex (DLPFC) T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339940; 4415617 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mathew, S V AU - Davila-Garcia, M I AU - Herman, M M AU - Kleinman, J E AU - Hyde, T M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Bungarotoxin KW - Cortex (prefrontal) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=%40%40u125%40I+a-Bungarotoxin+Binding+Sites+within+the+Human+Dorsolateral+Prefrontal+Cortex+%28DLPFC%29&rft.au=Mathew%2C+S+V%3BDavila-Garcia%2C+M+I%3BHerman%2C+M+M%3BKleinman%2C+J+E%3BHyde%2C+T+M&rft.aulast=Mathew&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Passive Avoidance Extinction: A n fMRI Investigation of the Extinction of Instrumentally Learned Avoidance and Approach T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339671; 4407131 JF - 36th Annual Meeting of the Society for Neuroscience AU - Finger, E C AU - Mitchell, D G AU - Jones, M AU - Blair, J R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Extinction KW - Functional magnetic resonance imaging KW - Avoidance reactions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339671?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Passive+Avoidance+Extinction%3A+A+n+fMRI+Investigation+of+the+Extinction+of+Instrumentally+Learned+Avoidance+and+Approach&rft.au=Finger%2C+E+C%3BMitchell%2C+D+G%3BJones%2C+M%3BBlair%2C+J+R&rft.aulast=Finger&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Responses in Monkey Area V4 and Pulvinar after Visual Shape Adaptation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339665; 4412975 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mueller, K AU - Wilke, M AU - Leopold, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Adaptations KW - Pulvinar KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339665?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Responses+in+Monkey+Area+V4+and+Pulvinar+after+Visual+Shape+Adaptation&rft.au=Mueller%2C+K%3BWilke%2C+M%3BLeopold%2C+D+A&rft.aulast=Mueller&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Brain Computer Interface Control of a Paralyzed Hand Utilizing Activity from Ipsilesional Sensorimotor Areas after Severe Chronic Subcortical Stroke T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40339152; 4409943 JF - 36th Annual Meeting of the Society for Neuroscience AU - Buch, E R AU - Weber, C AU - Birbaumer, N AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Sensorimotor system KW - Stroke KW - Hand KW - Computer applications KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40339152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Brain+Computer+Interface+Control+of+a+Paralyzed+Hand+Utilizing+Activity+from+Ipsilesional+Sensorimotor+Areas+after+Severe+Chronic+Subcortical+Stroke&rft.au=Buch%2C+E+R%3BWeber%2C+C%3BBirbaumer%2C+N%3BCohen%2C+L+G&rft.aulast=Buch&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Juvenile Social Interactions and Pup Ultrasonic Vocalizations in BTBR T@@u+@ tf/J Versus C57Bl/6J Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338792; 4408695 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mcfarlane, H G AU - Scattoni, M L AU - Crawley, J N Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Volatile organic compounds KW - Ultrasonics KW - Mice KW - Social interactions KW - Vocalization behaviour KW - Social behavior KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338792?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Juvenile+Social+Interactions+and+Pup+Ultrasonic+Vocalizations+in+BTBR+T%40%40u%2B%40+tf%2FJ+Versus+C57Bl%2F6J+Mice&rft.au=Mcfarlane%2C+H+G%3BScattoni%2C+M+L%3BCrawley%2C+J+N&rft.aulast=Mcfarlane&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sustained Angiotensin II AT1 Receptor Antagonism Attenuates the Hormonal Response to Peripheral Administration of Lipopolysaccharide to Normotensive Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338711; 4411871 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sanchez-Lemus, E AU - Moughamian, A J AU - Nishioku, T AU - Larrayoz, I M AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antagonism KW - Rats KW - Lipopolysaccharides KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338711?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sustained+Angiotensin+II+AT1+Receptor+Antagonism+Attenuates+the+Hormonal+Response+to+Peripheral+Administration+of+Lipopolysaccharide+to+Normotensive+Rats&rft.au=Sanchez-Lemus%2C+E%3BMoughamian%2C+A+J%3BNishioku%2C+T%3BLarrayoz%2C+I+M%3BSaavedra%2C+J+M&rft.aulast=Sanchez-Lemus&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dynamic Re-Grouping of Visual Categories with and without Motor Association in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338653; 4407990 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lerchner, A AU - Minamimoto, T AU - Soucy, D P AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Motors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dynamic+Re-Grouping+of+Visual+Categories+with+and+without+Motor+Association+in+Monkeys&rft.au=Lerchner%2C+A%3BMinamimoto%2C+T%3BSoucy%2C+D+P%3BRichmond%2C+B+J&rft.aulast=Lerchner&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effects of Acute Immobilization Stress in Adult Male Fragile X Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338601; 4409019 JF - 36th Annual Meeting of the Society for Neuroscience AU - Qin, M AU - Xia, Z AU - Smith, C B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Stress KW - Mice KW - Immobilization KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338601?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effects+of+Acute+Immobilization+Stress+in+Adult+Male+Fragile+X+Mice&rft.au=Qin%2C+M%3BXia%2C+Z%3BSmith%2C+C+B&rft.aulast=Qin&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Dopamine in Habit Formation Versus Cognitive Memory T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338578; 4407989 JF - 36th Annual Meeting of the Society for Neuroscience AU - Turchi, J N AU - Castillo, O AU - Saunders, R C AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cognitive ability KW - Memory KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Role+of+Dopamine+in+Habit+Formation+Versus+Cognitive+Memory&rft.au=Turchi%2C+J+N%3BCastillo%2C+O%3BSaunders%2C+R+C%3BMishkin%2C+M&rft.aulast=Turchi&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Expression Profile of Disc1 in Human Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338547; 4408913 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lipska, B K AU - Halim, N AU - Mitkus, S AU - Hyde, T M AU - Weinberger, D R AU - Kleinman, J E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - DISC1 protein KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338547?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Expression+Profile+of+Disc1+in+Human+Brain&rft.au=Lipska%2C+B+K%3BHalim%2C+N%3BMitkus%2C+S%3BHyde%2C+T+M%3BWeinberger%2C+D+R%3BKleinman%2C+J+E&rft.aulast=Lipska&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Temporal Encoding of Auditory Objects in Rostral Superior Temporal Cortex of Behaving Macaques T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338214; 4411591 JF - 36th Annual Meeting of the Society for Neuroscience AU - Scott, B H AU - Yin, P AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cortex (temporal) KW - Coding KW - Cortex (auditory) KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338214?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Temporal+Encoding+of+Auditory+Objects+in+Rostral+Superior+Temporal+Cortex+of+Behaving+Macaques&rft.au=Scott%2C+B+H%3BYin%2C+P%3BMishkin%2C+M&rft.aulast=Scott&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Specific Developmental Reductions in Subventricular Zone erbB1 and erbB4 Receptor mRNA Expression in the Human Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40338058; 4408915 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chong, V Z AU - Webster, M J AU - Weickert, C Shannon Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Gene expression KW - ErbB-2 protein KW - ErbB-1 protein KW - Subventricular zone KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40338058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Specific+Developmental+Reductions+in+Subventricular+Zone+erbB1+and+erbB4+Receptor+mRNA+Expression+in+the+Human+Brain&rft.au=Chong%2C+V+Z%3BWebster%2C+M+J%3BWeickert%2C+C+Shannon&rft.aulast=Chong&rft.aufirst=V&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Using Lentiviral-Generated RNA Interference to Investigate the Role of different G-Protein Subunit Isoforms in Voltage-Dependent Inhibition of N-Type Voltage-Gated Ca@@d2+@ Channels in Rat Superior Cervical Ganglia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337881; 4407612 JF - 36th Annual Meeting of the Society for Neuroscience AU - Williams, D J AU - Puhl, H L AU - Ikeda, S R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - RNA-mediated interference KW - Ganglia KW - Guanine nucleotide-binding protein KW - Calcium channels (voltage-gated) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Using+Lentiviral-Generated+RNA+Interference+to+Investigate+the+Role+of+different+G-Protein+Subunit+Isoforms+in+Voltage-Dependent+Inhibition+of+N-Type+Voltage-Gated+Ca%40%40d2%2B%40+Channels+in+Rat+Superior+Cervical+Ganglia&rft.au=Williams%2C+D+J%3BPuhl%2C+H+L%3BIkeda%2C+S+R&rft.aulast=Williams&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Learning of Visual Categories without Instruction in Monkeys T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337879; 4407994 JF - 36th Annual Meeting of the Society for Neuroscience AU - Soucy, D P AU - Richmond, B J AU - Minamimoto, T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Visual discrimination learning KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Rapid+Learning+of+Visual+Categories+without+Instruction+in+Monkeys&rft.au=Soucy%2C+D+P%3BRichmond%2C+B+J%3BMinamimoto%2C+T&rft.aulast=Soucy&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuroprotective Effects of Lamotrigine in Rat Brain Neurons: Synergy with Mood Stabilizers T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337518; 4410692 JF - 36th Annual Meeting of the Society for Neuroscience AU - Leng, Y AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Neuroprotection KW - Mood KW - Lamotrigine KW - Neurons KW - Stabilizers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuroprotective+Effects+of+Lamotrigine+in+Rat+Brain+Neurons%3A+Synergy+with+Mood+Stabilizers&rft.au=Leng%2C+Y%3BChuang%2C+D&rft.aulast=Leng&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dysregulation of Granule Cell Migration by Ethanol Examined using Transgenic Mice Expressing Green Fluorescent Protein under the GAP43 Promotor T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337494; 4408966 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hassoun, A T AU - Lovinger, D M AU - Davis, M I Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Mice KW - Granule cells KW - Cell migration KW - Green fluorescent protein KW - Transgenic mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337494?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Dysregulation+of+Granule+Cell+Migration+by+Ethanol+Examined+using+Transgenic+Mice+Expressing+Green+Fluorescent+Protein+under+the+GAP43+Promotor&rft.au=Hassoun%2C+A+T%3BLovinger%2C+D+M%3BDavis%2C+M+I&rft.aulast=Hassoun&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Frequency-Dependent and D2 Receptor-Mediated Inhibition of Glutamate Release by Retrograde Endocannabinoid Signaling T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40337140; 4406661 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yin, H H AU - Lovinger, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Glutamic acid KW - Cannabinoids KW - Frequency dependence KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40337140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Frequency-Dependent+and+D2+Receptor-Mediated+Inhibition+of+Glutamate+Release+by+Retrograde+Endocannabinoid+Signaling&rft.au=Yin%2C+H+H%3BLovinger%2C+D&rft.aulast=Yin&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuregulin-1-Induced, Integrin-Mediated Cell Adhesion is Impaired in Schizophrenia T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336993; 4408911 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kanakry, C G AU - Li, Z. AU - Sei, Y AU - Weinberger, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Schizophrenia KW - Cell adhesion KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuregulin-1-Induced%2C+Integrin-Mediated+Cell+Adhesion+is+Impaired+in+Schizophrenia&rft.au=Kanakry%2C+C+G%3BLi%2C+Z.%3BSei%2C+Y%3BWeinberger%2C+D+R&rft.aulast=Kanakry&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antidepressant-Like Actions of Fluoxetine Treatment in GALR2 Null Mutant Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336980; 4407154 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bailey, K R AU - Hohmann, J G AU - Zeng, H AU - Crawley, J N Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Antidepressants KW - Mice KW - Mutants KW - Fluoxetine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Antidepressant-Like+Actions+of+Fluoxetine+Treatment+in+GALR2+Null+Mutant+Mice&rft.au=Bailey%2C+K+R%3BHohmann%2C+J+G%3BZeng%2C+H%3BCrawley%2C+J+N&rft.aulast=Bailey&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Localizations and Functions of STAM Adaptor Molecules T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336847; 4407397 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rismanchi, N AU - Blackstone, C D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Cell death KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Differential+Localizations+and+Functions+of+STAM+Adaptor+Molecules&rft.au=Rismanchi%2C+N%3BBlackstone%2C+C+D&rft.aulast=Rismanchi&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Risks, Rewards, and the Alcoholic Brain: An fMRI Investigation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336564; 4413589 JF - 36th Annual Meeting of the Society for Neuroscience AU - Bjork, J M AU - Hommer, D W AU - Murthy, S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Reinforcement KW - Alcoholics KW - Functional magnetic resonance imaging KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Risks%2C+Rewards%2C+and+the+Alcoholic+Brain%3A+An+fMRI+Investigation&rft.au=Bjork%2C+J+M%3BHommer%2C+D+W%3BMurthy%2C+S&rft.aulast=Bjork&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Various Presynaptic Proteins are Transported in Heterogeneous Packets, Multivesicle T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336523; 4411504 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tao-Cheng, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336523?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Various+Presynaptic+Proteins+are+Transported+in+Heterogeneous+Packets%2C+Multivesicle&rft.au=Tao-Cheng%2C+J&rft.aulast=Tao-Cheng&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Measurement of Fret Efficiency and Relative Abundance of Donor and Acceptor Molecules in Living Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40336342; 4410865 JF - 36th Annual Meeting of the Society for Neuroscience AU - Chen, H AU - Puhl III, H L AU - Koushik, S V AU - Vogel, S S AU - Ikeda, S R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Abundance KW - Fluorescence resonance energy transfer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40336342?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Measurement+of+Fret+Efficiency+and+Relative+Abundance+of+Donor+and+Acceptor+Molecules+in+Living+Cells&rft.au=Chen%2C+H%3BPuhl+III%2C+H+L%3BKoushik%2C+S+V%3BVogel%2C+S+S%3BIkeda%2C+S+R&rft.aulast=Chen&rft.aufirst=H&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Effect of Voluntary Contraction of Lower-Limb Muscles on Motor-Evoked Responses in the Contralateral Resting Leg T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335512; 4409926 JF - 36th Annual Meeting of the Society for Neuroscience AU - Perez, M A AU - Nielsen, J B AU - Drucaroff, B AU - Hidler, J AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Muscle contraction KW - Leg KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Effect+of+Voluntary+Contraction+of+Lower-Limb+Muscles+on+Motor-Evoked+Responses+in+the+Contralateral+Resting+Leg&rft.au=Perez%2C+M+A%3BNielsen%2C+J+B%3BDrucaroff%2C+B%3BHidler%2C+J%3BCohen%2C+L+G&rft.aulast=Perez&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nongenotoxic Transcriptional Activation of Tumor Suppressor P53 by NGF-Mediated Neuronal Differentiation is Revealed Via Genomic Interrogation of P53 DNA Binding T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335502; 4408755 JF - 36th Annual Meeting of the Society for Neuroscience AU - Brynczka, C AU - Merrick, B A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - P53 protein KW - Transcription activation KW - Differentiation KW - Genomics KW - Tumor suppressor genes KW - Tumors KW - Suppressors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Nongenotoxic+Transcriptional+Activation+of+Tumor+Suppressor+P53+by+NGF-Mediated+Neuronal+Differentiation+is+Revealed+Via+Genomic+Interrogation+of+P53+DNA+Binding&rft.au=Brynczka%2C+C%3BMerrick%2C+B+A&rft.aulast=Brynczka&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAP6 in Schizophrenia: Genetic Association and mRNA Expression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335339; 4408912 JF - 36th Annual Meeting of the Society for Neuroscience AU - Saylor, E M AU - Joseph, L T AU - Mitkus, S N AU - Hyde, T M AU - Nicodemus, K K AU - Callicott, J H AU - Straub, R E AU - Vakkalanka, R K AU - Kleinman, J E AU - Weinberger, D R AU - Lipska, B K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Gene expression KW - Schizophrenia KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAP6+in+Schizophrenia%3A+Genetic+Association+and+mRNA+Expression&rft.au=Saylor%2C+E+M%3BJoseph%2C+L+T%3BMitkus%2C+S+N%3BHyde%2C+T+M%3BNicodemus%2C+K+K%3BCallicott%2C+J+H%3BStraub%2C+R+E%3BVakkalanka%2C+R+K%3BKleinman%2C+J+E%3BWeinberger%2C+D+R%3BLipska%2C+B+K&rft.aulast=Saylor&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Ethanol Modulation of D@@d1@ Receptor Signaling Appears to be Mediated by Protein Kinase C in an Isoform-Specific Fashion T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335188; 4407578 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rex, E B AU - Rankin, M L AU - Cabrera, D M AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ethanol KW - Signal transduction KW - Protein kinase C KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Ethanol+Modulation+of+D%40%40d1%40+Receptor+Signaling+Appears+to+be+Mediated+by+Protein+Kinase+C+in+an+Isoform-Specific+Fashion&rft.au=Rex%2C+E+B%3BRankin%2C+M+L%3BCabrera%2C+D+M%3BSibley%2C+D+R&rft.aulast=Rex&rft.aufirst=E&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fos-like Activity in the Brains of Vocalizing Common Marmoset Infants T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335183; 4412230 JF - 36th Annual Meeting of the Society for Neuroscience AU - Newman, J D AU - Aronoff, E C AU - Rakhovskaya, M V AU - Bernhards, D E Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Volatile organic compounds KW - Infants KW - Brain KW - Callithrix KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335183?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Fos-like+Activity+in+the+Brains+of+Vocalizing+Common+Marmoset+Infants&rft.au=Newman%2C+J+D%3BAronoff%2C+E+C%3BRakhovskaya%2C+M+V%3BBernhards%2C+D+E&rft.aulast=Newman&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacological Characterization of the Interactions of Methylnorapomorphine (MNPA) with D@@d2@ Dopamine Receptors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40335139; 4407576 JF - 36th Annual Meeting of the Society for Neuroscience AU - Skinbjerg, M AU - Namkung, Y AU - Halldin, C AU - Innis, R B AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40335139?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Pharmacological+Characterization+of+the+Interactions+of+Methylnorapomorphine+%28MNPA%29+with+D%40%40d2%40+Dopamine+Receptors&rft.au=Skinbjerg%2C+M%3BNamkung%2C+Y%3BHalldin%2C+C%3BInnis%2C+R+B%3BSibley%2C+D+R&rft.aulast=Skinbjerg&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sorting Nexin-25 Regulates D@@d1@ and D@@d2@ Dopamine Receptor Expression and Signaling T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334929; 4407575 JF - 36th Annual Meeting of the Society for Neuroscience AU - Free, R AU - Hazelwood, L A AU - Cabrera, D M AU - Spalding, H N AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Sorting+Nexin-25+Regulates+D%40%40d1%40+and+D%40%40d2%40+Dopamine+Receptor+Expression+and+Signaling&rft.au=Free%2C+R%3BHazelwood%2C+L+A%3BCabrera%2C+D+M%3BSpalding%2C+H+N%3BSibley%2C+D+R&rft.aulast=Free&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of PKA, PKC and CaMKII Phosphorylation Sites in the C-Terminus of the GluR6 Subunit T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334912; 4412756 JF - 36th Annual Meeting of the Society for Neuroscience AU - Nishimura, Y AU - Kelver, D AU - Braud, S AU - Isaac, J T AU - Roche, K W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Protein kinase A KW - C-Terminus KW - Phosphorylation KW - Protein kinase C KW - Ca@@u2+@/calmodulin-dependent protein kinase II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+PKA%2C+PKC+and+CaMKII+Phosphorylation+Sites+in+the+C-Terminus+of+the+GluR6+Subunit&rft.au=Nishimura%2C+Y%3BKelver%2C+D%3BBraud%2C+S%3BIsaac%2C+J+T%3BRoche%2C+K+W&rft.aulast=Nishimura&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Angiotensin II AT1 Receptor Blockade Reduces the Innate Inflammatory Response to Lipopolysaccharide in Rat Brain T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334828; 4410720 JF - 36th Annual Meeting of the Society for Neuroscience AU - Larrayoz, I M AU - Nishioku, T AU - Benicky, J AU - Murakami, Y AU - De Nicola, A F AU - Saavedra, J M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Brain KW - Lipopolysaccharides KW - Inflammation KW - Angiotensin II KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Angiotensin+II+AT1+Receptor+Blockade+Reduces+the+Innate+Inflammatory+Response+to+Lipopolysaccharide+in+Rat+Brain&rft.au=Larrayoz%2C+I+M%3BNishioku%2C+T%3BBenicky%2C+J%3BMurakami%2C+Y%3BDe+Nicola%2C+A+F%3BSaavedra%2C+J+M&rft.aulast=Larrayoz&rft.aufirst=I&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Presynaptic Glutamate Release in the Cortical Input to the Lateral Amygdala Coincides with the Deficit of Fear Learning in Rap1A/Rap1B Double Knock-Out Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334819; 4410351 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pan, B AU - Vautier, F AU - Ito, W AU - Morozov, A Y Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Glutamic acid KW - Learning KW - Fear KW - Amygdala KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Enhanced+Presynaptic+Glutamate+Release+in+the+Cortical+Input+to+the+Lateral+Amygdala+Coincides+with+the+Deficit+of+Fear+Learning+in+Rap1A%2FRap1B+Double+Knock-Out+Mice&rft.au=Pan%2C+B%3BVautier%2C+F%3BIto%2C+W%3BMorozov%2C+A+Y&rft.aulast=Pan&rft.aufirst=B&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Free Fatty Acids Alter the Function of Ligand-Gated Ion Channels Expressed in Xenopus Oocytes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334657; 4407511 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kloda, J H AU - Mitchell, D C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Fatty acids KW - Ion channels (ligand-gated) KW - Oocytes KW - Amphibiotic species KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Free+Fatty+Acids+Alter+the+Function+of+Ligand-Gated+Ion+Channels+Expressed+in+Xenopus+Oocytes&rft.au=Kloda%2C+J+H%3BMitchell%2C+D+C&rft.aulast=Kloda&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Emotional Processing of High-Arousal Positive and Negative Images in Alcohol-Dependent Patients T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334627; 4408945 JF - 36th Annual Meeting of the Society for Neuroscience AU - Gilman, J M AU - Salloum, J B AU - Hommer, D W Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Emotions KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Emotional+Processing+of+High-Arousal+Positive+and+Negative+Images+in+Alcohol-Dependent+Patients&rft.au=Gilman%2C+J+M%3BSalloum%2C+J+B%3BHommer%2C+D+W&rft.aulast=Gilman&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interhemispheric Inhibition in Distal and Proximal ARM Representations in the Primary Motor Cortex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334554; 4409911 JF - 36th Annual Meeting of the Society for Neuroscience AU - Harris-Love, M L AU - Chen, R AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cerebral hemispheres KW - Cortex (motor) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interhemispheric+Inhibition+in+Distal+and+Proximal+ARM+Representations+in+the+Primary+Motor+Cortex&rft.au=Harris-Love%2C+M+L%3BChen%2C+R%3BCohen%2C+L+G&rft.aulast=Harris-Love&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Association Studies of Human Metabotropic Glutamate Receptors in Drug Addiction T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334501; 4412563 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhang, P AU - Liu, Q AU - Drgon, T AU - Walther, D AU - Johnson, C AU - Uhl, G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Drug addiction KW - Glutamic acid receptors (metabotropic) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Association+Studies+of+Human+Metabotropic+Glutamate+Receptors+in+Drug+Addiction&rft.au=Zhang%2C+P%3BLiu%2C+Q%3BDrgon%2C+T%3BWalther%2C+D%3BJohnson%2C+C%3BUhl%2C+G&rft.aulast=Zhang&rft.aufirst=P&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction of Distractibility and Task Difficulty in ADHD T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334458; 4410264 JF - 36th Annual Meeting of the Society for Neuroscience AU - Wagman, M R AU - Friedman-Hill, S R AU - Speer, A M AU - Pine, D S AU - Leibenluft, E AU - Ungerleider, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Attention KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Interaction+of+Distractibility+and+Task+Difficulty+in+ADHD&rft.au=Wagman%2C+M+R%3BFriedman-Hill%2C+S+R%3BSpeer%2C+A+M%3BPine%2C+D+S%3BLeibenluft%2C+E%3BUngerleider%2C+L+G&rft.aulast=Wagman&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Representation of Auditory Stimulus-Quality in the Monkey's Rostral Supratemporal Plane T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334439; 4411594 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kikuchi, Y AU - Horwitz, B AU - Mishkin, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cortex (auditory) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334439?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Representation+of+Auditory+Stimulus-Quality+in+the+Monkey%27s+Rostral+Supratemporal+Plane&rft.au=Kikuchi%2C+Y%3BHorwitz%2C+B%3BMishkin%2C+M&rft.aulast=Kikuchi&rft.aufirst=Y&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Substrates Underlying Intermanual Transfer of Procedural Knowledge. II. Supplementary Motor Area T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334280; 4409913 JF - 36th Annual Meeting of the Society for Neuroscience AU - Tanaka, S AU - Perez, M A AU - Reis, J AU - Wise, S P AU - Willingham, D T AU - Cohen, L G Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Supplementary motor area KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Substrates+Underlying+Intermanual+Transfer+of+Procedural+Knowledge.+II.+Supplementary+Motor+Area&rft.au=Tanaka%2C+S%3BPerez%2C+M+A%3BReis%2C+J%3BWise%2C+S+P%3BWillingham%2C+D+T%3BCohen%2C+L+G&rft.aulast=Tanaka&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Acute and Gradual Increases in BDNF Concentration Elicit Distinct Signaling and Functions in Hippocampal Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334241; 4412721 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ji, Y. AU - Shen, W AU - Woo, N H AU - Feng, L AU - Duan, S AU - Lu, B. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Signal transduction KW - Brain-derived neurotrophic factor KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Acute+and+Gradual+Increases+in+BDNF+Concentration+Elicit+Distinct+Signaling+and+Functions+in+Hippocampal+Neurons&rft.au=Ji%2C+Y.%3BShen%2C+W%3BWoo%2C+N+H%3BFeng%2C+L%3BDuan%2C+S%3BLu%2C+B.&rft.aulast=Ji&rft.aufirst=Y.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective Nucleus Accumbens and Medial Frontal Cortex Activation in Appetitive Picture Processing T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334224; 4408197 JF - 36th Annual Meeting of the Society for Neuroscience AU - Sabatinelli, D AU - Versace, F AU - Costa, V D AU - Bradley, M M AU - Lang, P J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Visual stimuli KW - Cortex (frontal) KW - Nucleus accumbens KW - Information processing KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+Nucleus+Accumbens+and+Medial+Frontal+Cortex+Activation+in+Appetitive+Picture+Processing&rft.au=Sabatinelli%2C+D%3BVersace%2C+F%3BCosta%2C+V+D%3BBradley%2C+M+M%3BLang%2C+P+J&rft.aulast=Sabatinelli&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Composition of the Synaptic PSD-95 Complex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40334102; 4411521 JF - 36th Annual Meeting of the Society for Neuroscience AU - Dosemeci, A AU - Makusky, A J AU - Yang, X AU - Tao-Cheng, J AU - Markey, S P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Postsynaptic density proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40334102?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Composition+of+the+Synaptic+PSD-95+Complex&rft.au=Dosemeci%2C+A%3BMakusky%2C+A+J%3BYang%2C+X%3BTao-Cheng%2C+J%3BMarkey%2C+S+P&rft.aulast=Dosemeci&rft.aufirst=A&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Interaction of the Adaptor Protein ARH with Bicaudal-D1 Suggests its Involvement in the Copi-Independent Golgi-ER Transport T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333916; 4411501 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mameza, M G AU - Gioio, A E AU - Kaplan, B B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Adaptor proteins KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333916?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+Interaction+of+the+Adaptor+Protein+ARH+with+Bicaudal-D1+Suggests+its+Involvement+in+the+Copi-Independent+Golgi-ER+Transport&rft.au=Mameza%2C+M+G%3BGioio%2C+A+E%3BKaplan%2C+B+B&rft.aulast=Mameza&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Identification of a Novel Motor Complex Involved in Axonal Trafficking of Active Zone Precursors and Presynaptic Assembly T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333754; 4410938 JF - 36th Annual Meeting of the Society for Neuroscience AU - Cai, Q AU - Pan, P Y AU - Sheng, Z H Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Motors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333754?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Identification+of+a+Novel+Motor+Complex+Involved+in+Axonal+Trafficking+of+Active+Zone+Precursors+and+Presynaptic+Assembly&rft.au=Cai%2C+Q%3BPan%2C+P+Y%3BSheng%2C+Z+H&rft.aulast=Cai&rft.aufirst=Q&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regulation of a-synuclein Phosphorylation in Mammalian Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333683; 4412358 JF - 36th Annual Meeting of the Society for Neuroscience AU - Miller, D W AU - Patel, N AU - Clarimon, J AU - Cookson, M R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mammalian cells KW - Synuclein KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333683?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regulation+of+a-synuclein+Phosphorylation+in+Mammalian+Cells&rft.au=Miller%2C+D+W%3BPatel%2C+N%3BClarimon%2C+J%3BCookson%2C+M+R&rft.aulast=Miller&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Insulin-like Growth Factor 1 (IGF1) Reduces Polyglutamine-expanded Androgen Receptor Toxicity in an SBMA Cell Model T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333167; 4412371 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ranganathan, S AU - Pennuto, M AU - Palazzolo, I AU - Howell, B AU - Fischbeck, K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Toxicity KW - Cell culture KW - Androgen receptors KW - Insulin-like growth factors KW - Insulin-like growth factor I KW - Sex hormones KW - Growth rate KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333167?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Insulin-like+Growth+Factor+1+%28IGF1%29+Reduces+Polyglutamine-expanded+Androgen+Receptor+Toxicity+in+an+SBMA+Cell+Model&rft.au=Ranganathan%2C+S%3BPennuto%2C+M%3BPalazzolo%2C+I%3BHowell%2C+B%3BFischbeck%2C+K&rft.aulast=Ranganathan&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Role of the Primate Habenula in Reward Processing. I. Prediction of Negative Reward Value T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40333006; 4410403 JF - 36th Annual Meeting of the Society for Neuroscience AU - Matsumoto, M AU - Hikosaka, O Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Reinforcement KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40333006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Role+of+the+Primate+Habenula+in+Reward+Processing.+I.+Prediction+of+Negative+Reward+Value&rft.au=Matsumoto%2C+M%3BHikosaka%2C+O&rft.aulast=Matsumoto&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAC1 Mediates LPS-induced Superoxide from Microglia: The Role of Phagocytosis Receptors in Dopaminergic Neurotoxicity T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332940; 4412417 JF - 36th Annual Meeting of the Society for Neuroscience AU - Block, M AU - Zhong, P AU - Pang, H AU - Wang, T AU - Wu, X. AU - Zhang, W AU - Dallas, S AU - Wilson, B AU - Miller, D AU - Hong, J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Neurotoxicity KW - Dopamine receptors KW - Microglia KW - Superoxide KW - Phagocytosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332940?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAC1+Mediates+LPS-induced+Superoxide+from+Microglia%3A+The+Role+of+Phagocytosis+Receptors+in+Dopaminergic+Neurotoxicity&rft.au=Block%2C+M%3BZhong%2C+P%3BPang%2C+H%3BWang%2C+T%3BWu%2C+X.%3BZhang%2C+W%3BDallas%2C+S%3BWilson%2C+B%3BMiller%2C+D%3BHong%2C+J&rft.aulast=Block&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neurotrophins and Integrins Regulate Survival of Hippocampal Neurons during Developmental Death Period T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332859; 4411125 JF - 36th Annual Meeting of the Society for Neuroscience AU - Murase, S AU - Owens, D F AU - Maughan, P H AU - Szklarczyk, A AU - Mckay, R D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Survival KW - Cell survival KW - Hippocampus KW - Integrins KW - Neurotrophins KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332859?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neurotrophins+and+Integrins+Regulate+Survival+of+Hippocampal+Neurons+during+Developmental+Death+Period&rft.au=Murase%2C+S%3BOwens%2C+D+F%3BMaughan%2C+P+H%3BSzklarczyk%2C+A%3BMckay%2C+R+D&rft.aulast=Murase&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preferential Migration of Conditionally Immortalized Hippocampal Neuronal Cell Lines to Dentate Gyrus and Associated Functional Recovery in Rats T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332610; 4411001 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pillai, R J AU - Chakravarthy, S AU - Alladi, P A AU - Balakrishnan, B AU - Ashok, G AU - Raju, T R AU - Panicker, M M AU - Kutty, B M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Rats KW - Recovery of function KW - Cell migration KW - Dentate gyrus KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332610?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Preferential+Migration+of+Conditionally+Immortalized+Hippocampal+Neuronal+Cell+Lines+to+Dentate+Gyrus+and+Associated+Functional+Recovery+in+Rats&rft.au=Pillai%2C+R+J%3BChakravarthy%2C+S%3BAlladi%2C+P+A%3BBalakrishnan%2C+B%3BAshok%2C+G%3BRaju%2C+T+R%3BPanicker%2C+M+M%3BKutty%2C+B+M&rft.aulast=Pillai&rft.aufirst=R&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Determinants for Polarized Targeting of PMCAs and the Turnover of Stereocilia Membrane Proteins in Mammalian Hair Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332578; 4406440 JF - 36th Annual Meeting of the Society for Neuroscience AU - Grati, M AU - Schneider, M AU - Aggarwal, N AU - Lipkow, K AU - Strehler, E E AU - Kachar, B AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Membrane proteins KW - Hair cells KW - Ca@@u2+@-transporting ATPase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Molecular+Determinants+for+Polarized+Targeting+of+PMCAs+and+the+Turnover+of+Stereocilia+Membrane+Proteins+in+Mammalian+Hair+Cells&rft.au=Grati%2C+M%3BSchneider%2C+M%3BAggarwal%2C+N%3BLipkow%2C+K%3BStrehler%2C+E+E%3BKachar%2C+B%3BWenthold%2C+R+J&rft.aulast=Grati&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Presynaptic Kainate Receptors Bidirectionaly Regulate Thalamocortical Transmission during Development T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40332468; 4412742 JF - 36th Annual Meeting of the Society for Neuroscience AU - Jouhanneau, J S AU - Isaac, J T Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - Kainic acid receptors KW - Cortex KW - Thalamus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40332468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Presynaptic+Kainate+Receptors+Bidirectionaly+Regulate+Thalamocortical+Transmission+during+Development&rft.au=Jouhanneau%2C+J+S%3BIsaac%2C+J+T&rft.aulast=Jouhanneau&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Adverse Rearing Increases Fear Potentiated Startle in Rhesus Monkeys and Fluoxetine Ameliorates this Effect T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331971; 4408048 JF - 36th Annual Meeting of the Society for Neuroscience AU - Winslow, J T AU - Nelson, E E AU - Noble, P L AU - Wojteczko, K A AU - Ycu, E A AU - Pine, D S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fluoxetine KW - Startle response KW - Fear KW - Macaca mulatta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Adverse+Rearing+Increases+Fear+Potentiated+Startle+in+Rhesus+Monkeys+and+Fluoxetine+Ameliorates+this+Effect&rft.au=Winslow%2C+J+T%3BNelson%2C+E+E%3BNoble%2C+P+L%3BWojteczko%2C+K+A%3BYcu%2C+E+A%3BPine%2C+D+S&rft.aulast=Winslow&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Participation of Lys313-Ile333 Sequence of P2X@@d4@ Receptor in Agonist Binding and Transduction of Signals to the Channel Gate T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331968; 4407541 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yan, Z AU - Liang, Z AU - Obsil, T AU - Stojilkovic, S S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Channels KW - Purine P2X receptors KW - Transduction KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331968?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Participation+of+Lys313-Ile333+Sequence+of+P2X%40%40d4%40+Receptor+in+Agonist+Binding+and+Transduction+of+Signals+to+the+Channel+Gate&rft.au=Yan%2C+Z%3BLiang%2C+Z%3BObsil%2C+T%3BStojilkovic%2C+S+S&rft.aulast=Yan&rft.aufirst=Z&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Induction of Filopodia and Branched Retraction Fibers by Transmembrane Agrin is Modulated by Agrin GAG Chains Via Activation of Cdc42 and Rac1 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331705; 4412698 JF - 36th Annual Meeting of the Society for Neuroscience AU - Lin, L AU - Mccroskery, S AU - Ross, J M AU - Daniels, M P Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Agrin KW - Rac1 protein KW - Cdc42 protein KW - Pseudopodia KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Induction+of+Filopodia+and+Branched+Retraction+Fibers+by+Transmembrane+Agrin+is+Modulated+by+Agrin+GAG+Chains+Via+Activation+of+Cdc42+and+Rac1&rft.au=Lin%2C+L%3BMccroskery%2C+S%3BRoss%2C+J+M%3BDaniels%2C+M+P&rft.aulast=Lin&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DAPT, a Gamma-Secretase Inhibitor Downregulates Cdk5 Activity in Rat Cortical Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331381; 4407759 JF - 36th Annual Meeting of the Society for Neuroscience AU - Kanungo, J AU - Zheng, Y AU - Pant, H C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Cyclin-dependent kinase 5 KW - Secretase KW - Cortex KW - Inhibitors KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331381?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=DAPT%2C+a+Gamma-Secretase+Inhibitor+Downregulates+Cdk5+Activity+in+Rat+Cortical+Neurons&rft.au=Kanungo%2C+J%3BZheng%2C+Y%3BPant%2C+H+C&rft.aulast=Kanungo&rft.aufirst=J&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - D@@d1@ and D@@d2@ Dopamine Receptor Interactions with the Na@@u+@/K@@u+@-Atpase Result in Reciprocal Modulation of Function T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331237; 4407577 JF - 36th Annual Meeting of the Society for Neuroscience AU - Hazelwood, L A AU - Free, R B AU - Cabrera, D M AU - Neiman, J AU - Sibley, D R Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Dopamine D1 receptors KW - Dopamine D2 receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=D%40%40d1%40+and+D%40%40d2%40+Dopamine+Receptor+Interactions+with+the+Na%40%40u%2B%40%2FK%40%40u%2B%40-Atpase+Result+in+Reciprocal+Modulation+of+Function&rft.au=Hazelwood%2C+L+A%3BFree%2C+R+B%3BCabrera%2C+D+M%3BNeiman%2C+J%3BSibley%2C+D+R&rft.aulast=Hazelwood&rft.aufirst=L&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - State-Dependent cAMP Sensitivity of Feedforward Inhibition in the Hippocampal Mossy Fiber Pathway T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40331215; 4406327 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pelkey, K A AU - Topolnik, L AU - Lacaille, J C AU - Mcbain, C J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Fibers KW - Hippocampus KW - Cyclic AMP KW - Mossy fibers KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40331215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=State-Dependent+cAMP+Sensitivity+of+Feedforward+Inhibition+in+the+Hippocampal+Mossy+Fiber+Pathway&rft.au=Pelkey%2C+K+A%3BTopolnik%2C+L%3BLacaille%2C+J+C%3BMcbain%2C+C+J&rft.aulast=Pelkey&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cdk5 Phosphorylation of Septin SEPT5 at Serine 327 Regulates Exocytosis T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330936; 4407655 JF - 36th Annual Meeting of the Society for Neuroscience AU - Amin, N AU - Kesavapany, S AU - Kanungo, J AU - Zheng, Y AU - Sihag, R AU - Albers, W AU - Grant, P AU - Pant, H C Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Septin KW - Serine KW - Exocytosis KW - Cyclin-dependent kinase 5 KW - Phosphorylation KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330936?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Cdk5+Phosphorylation+of+Septin+SEPT5+at+Serine+327+Regulates+Exocytosis&rft.au=Amin%2C+N%3BKesavapany%2C+S%3BKanungo%2C+J%3BZheng%2C+Y%3BSihag%2C+R%3BAlbers%2C+W%3BGrant%2C+P%3BPant%2C+H+C&rft.aulast=Amin&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synaptic Plasticity (and Lack Thereof) in Hippocampal CA2 T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330688; 4406344 JF - 36th Annual Meeting of the Society for Neuroscience AU - Zhao, M AU - Dudek, S M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Hippocampus KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330688?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Synaptic+Plasticity+%28and+Lack+Thereof%29+in+Hippocampal+CA2&rft.au=Zhao%2C+M%3BDudek%2C+S+M&rft.aulast=Zhao&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neuronal Activity in the Zona Incerta of the Monkey is Related to Motivational States in a Reward Schedule Task T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40330510; 4408102 JF - 36th Annual Meeting of the Society for Neuroscience AU - Ravel, S P AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Reinforcement KW - Zona incerta KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40330510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neuronal+Activity+in+the+Zona+Incerta+of+the+Monkey+is+Related+to+Motivational+States+in+a+Reward+Schedule+Task&rft.au=Ravel%2C+S+P%3BRichmond%2C+B+J&rft.aulast=Ravel&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The A-Type K@@u+@ Channel Subunit Kv4.2 Controls Functional NR2B Activity through a Ca@@u2+@-Dependent Mechanism in Hippocampal CA1 Pyramidal Neurons T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329417; 4406338 JF - 36th Annual Meeting of the Society for Neuroscience AU - Jung, S AU - Kim, J AU - Hoffman, D A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Potassium channels KW - Pyramidal cells KW - Potassium channels (voltage-gated) KW - Calcium KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+A-Type+K%40%40u%2B%40+Channel+Subunit+Kv4.2+Controls+Functional+NR2B+Activity+through+a+Ca%40%40u2%2B%40-Dependent+Mechanism+in+Hippocampal+CA1+Pyramidal+Neurons&rft.au=Jung%2C+S%3BKim%2C+J%3BHoffman%2C+D+A&rft.aulast=Jung&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Regional Expression of Fmr1, Fxr1, and Fxr2 mRNAs in Brains of Adult Male and Female Wild-Type Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329313; 4409021 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yang, C H AU - Xing, G Q AU - Smith, C B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Brain KW - MRNA KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Regional+Expression+of+Fmr1%2C+Fxr1%2C+and+Fxr2+mRNAs+in+Brains+of+Adult+Male+and+Female+Wild-Type+Mice&rft.au=Yang%2C+C+H%3BXing%2C+G+Q%3BSmith%2C+C+B&rft.aulast=Yang&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Action Potential Failure in a Presynaptic CNS Nerve Terminal Following a Train of Action Potentials T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329311; 4406311 JF - 36th Annual Meeting of the Society for Neuroscience AU - Paradiso, K G AU - Wu, L. Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Action potential KW - Central nervous system KW - Nerve endings KW - Nerves KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Action+Potential+Failure+in+a+Presynaptic+CNS+Nerve+Terminal+Following+a+Train+of+Action+Potentials&rft.au=Paradiso%2C+K+G%3BWu%2C+L.&rft.aulast=Paradiso&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MAP Kinase Role in p53-Mediated Apoptosis in Rat Neural Af5 Cells after Hydrogen Peroxide T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40329031; 4408546 JF - 36th Annual Meeting of the Society for Neuroscience AU - Mcneil-Blue, C AU - Merrick, B A Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Hydrogen peroxide KW - MAP kinase KW - Apoptosis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40329031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=MAP+Kinase+Role+in+p53-Mediated+Apoptosis+in+Rat+Neural+Af5+Cells+after+Hydrogen+Peroxide&rft.au=Mcneil-Blue%2C+C%3BMerrick%2C+B+A&rft.aulast=Mcneil-Blue&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Curcumin Protects Dopaminergic Neurons through Inhibition of Microglia Overactivation T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328510; 4408260 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yang, S AU - Yang, Z AU - Pang, H AU - Gao, X AU - Wilson, B C AU - Block, M AU - Hong, J S Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Curcumin KW - Microglia KW - Neurons KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328510?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Curcumin+Protects+Dopaminergic+Neurons+through+Inhibition+of+Microglia+Overactivation&rft.au=Yang%2C+S%3BYang%2C+Z%3BPang%2C+H%3BGao%2C+X%3BWilson%2C+B+C%3BBlock%2C+M%3BHong%2C+J+S&rft.aulast=Yang&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neural Signals Related to Predicted and Elapsed Delay to Reward in the Primate Anterior Cingulate Cortex T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328292; 4410389 JF - 36th Annual Meeting of the Society for Neuroscience AU - Minamimoto, T AU - Richmond, B J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Primates KW - Reinforcement KW - Cortex (cingulate) KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Neural+Signals+Related+to+Predicted+and+Elapsed+Delay+to+Reward+in+the+Primate+Anterior+Cingulate+Cortex&rft.au=Minamimoto%2C+T%3BRichmond%2C+B+J&rft.aulast=Minamimoto&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GIPC, a Single PDZ Domain-Containing Protein, Interacts with the NMDA Receptor and Regulates its Surface Expression T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40328138; 4406207 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yi, Z. AU - Petralia, R S AU - Prybylowski, K AU - Sans, N AU - Wang, Y X AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40328138?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GIPC%2C+a+Single+PDZ+Domain-Containing+Protein%2C+Interacts+with+the+NMDA+Receptor+and+Regulates+its+Surface+Expression&rft.au=Yi%2C+Z.%3BPetralia%2C+R+S%3BPrybylowski%2C+K%3BSans%2C+N%3BWang%2C+Y+X%3BWenthold%2C+R+J&rft.aulast=Yi&rft.aufirst=Z.&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The SALM Family of Adhesion-Like Molecules Forms Heteromeric and Homomeric Complexes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40327909; 4406198 JF - 36th Annual Meeting of the Society for Neuroscience AU - Seabold, G K AU - Wang, C Y AU - Chang, K AU - Petralia, R S AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327909?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=The+SALM+Family+of+Adhesion-Like+Molecules+Forms+Heteromeric+and+Homomeric+Complexes&rft.au=Seabold%2C+G+K%3BWang%2C+C+Y%3BChang%2C+K%3BPetralia%2C+R+S%3BWenthold%2C+R+J&rft.aulast=Seabold&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selective White Matter Differences in Spasmodic Dysphonia: A DTI Study T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40327155; 4408296 JF - 36th Annual Meeting of the Society for Neuroscience AU - Simonyan, K AU - Tovar-Moll, F AU - Ostuni, J AU - Hattori, N AU - Hallett, M AU - Ludlow, C L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Substantia alba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40327155?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Selective+White+Matter+Differences+in+Spasmodic+Dysphonia%3A+A+DTI+Study&rft.au=Simonyan%2C+K%3BTovar-Moll%2C+F%3BOstuni%2C+J%3BHattori%2C+N%3BHallett%2C+M%3BLudlow%2C+C+L&rft.aulast=Simonyan&rft.aufirst=K&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interaction of N-Methyl-D-Aspartate (NMDA) Receptors with Flotillin-1, a Lipid Raft-Associated Protein T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40325063; 4406197 JF - 36th Annual Meeting of the Society for Neuroscience AU - Swanwick, C C AU - Chang, K AU - Wenthold, R J Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Lipids KW - Glutamic acid receptors KW - N-Methyl-D-aspartic acid receptors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40325063?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Interaction+of+N-Methyl-D-Aspartate+%28NMDA%29+Receptors+with+Flotillin-1%2C+a+Lipid+Raft-Associated+Protein&rft.au=Swanwick%2C+C+C%3BChang%2C+K%3BWenthold%2C+R+J&rft.aulast=Swanwick&rft.aufirst=C&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Valproic Acid-induced BDNF Promoter III Activity in Cortical Neurons and Neuroblastoma Cells: Role of HDAC Subtypes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324902; 4405944 JF - 36th Annual Meeting of the Society for Neuroscience AU - Yasuda, S AU - Liang, M AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Promoters KW - Neuroblastoma cells KW - Histone deacetylase KW - Cortex KW - Brain-derived neurotrophic factor KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324902?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Valproic+Acid-induced+BDNF+Promoter+III+Activity+in+Cortical+Neurons+and+Neuroblastoma+Cells%3A+Role+of+HDAC+Subtypes&rft.au=Yasuda%2C+S%3BLiang%2C+M%3BChuang%2C+D&rft.aulast=Yasuda&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fibroblast Growth Factor Receptors Differentially Regulate the Self-Renewing and Neurogenic Properties of Cortical Neural Stem Cells T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324506; 4409117 JF - 36th Annual Meeting of the Society for Neuroscience AU - Maric, D AU - Chang, Y H AU - Barker, J L Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Stem cells KW - Fibroblast growth factor receptors KW - Cortex KW - Neural stem cells KW - Growth KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324506?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Fibroblast+Growth+Factor+Receptors+Differentially+Regulate+the+Self-Renewing+and+Neurogenic+Properties+of+Cortical+Neural+Stem+Cells&rft.au=Maric%2C+D%3BChang%2C+Y+H%3BBarker%2C+J+L&rft.aulast=Maric&rft.aufirst=D&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMDA-Induced Death of Hippocampal CA1 Neurons in Slice Culture is Mediated by Mitochondrial Damage T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40324454; 4408464 JF - 36th Annual Meeting of the Society for Neuroscience AU - Pivovarova, N B AU - Brantner, C A AU - Winters, C A AU - Andrews, S B Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mortality KW - Mitochondria KW - Hippocampus KW - Neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40324454?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=NMDA-Induced+Death+of+Hippocampal+CA1+Neurons+in+Slice+Culture+is+Mediated+by+Mitochondrial+Damage&rft.au=Pivovarova%2C+N+B%3BBrantner%2C+C+A%3BWinters%2C+C+A%3BAndrews%2C+S+B&rft.aulast=Pivovarova&rft.aufirst=N&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - BAG1 Overexpression Reduces Manic-Like and Depression-Like Behavior in Mice T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40323397; 4406001 JF - 36th Annual Meeting of the Society for Neuroscience AU - Maeng, S AU - Creson, T AU - Shaltiel, G AU - Gould, T AU - Du, J. AU - Chen, G AU - Reed, J C AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40323397?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=BAG1+Overexpression+Reduces+Manic-Like+and+Depression-Like+Behavior+in+Mice&rft.au=Maeng%2C+S%3BCreson%2C+T%3BShaltiel%2C+G%3BGould%2C+T%3BDu%2C+J.%3BChen%2C+G%3BReed%2C+J+C%3BManji%2C+H+K&rft.aulast=Maeng&rft.aufirst=S&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PET Imaging with [11C]PBR28 can Localize and Quantify Up-Regulated Peripheral Benzodiazepine Receptors Associated with Cerebral Ischemia in Rat T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40322557; 4405880 JF - 36th Annual Meeting of the Society for Neuroscience AU - Imaizumi, M AU - Kim, H AU - Zoghbi, S S AU - Briard, E AU - Hong, J AU - Musachio, J L AU - Chuang, D AU - Pike, V W AU - Innis, R B AU - Fujita, M Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Ischemia KW - Benzodiazepine receptors KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40322557?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=PET+Imaging+with+%5B11C%5DPBR28+can+Localize+and+Quantify+Up-Regulated+Peripheral+Benzodiazepine+Receptors+Associated+with+Cerebral+Ischemia+in+Rat&rft.au=Imaizumi%2C+M%3BKim%2C+H%3BZoghbi%2C+S+S%3BBriard%2C+E%3BHong%2C+J%3BMusachio%2C+J+L%3BChuang%2C+D%3BPike%2C+V+W%3BInnis%2C+R+B%3BFujita%2C+M&rft.aulast=Imaizumi&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Histone Deacetylase Inhibitors Valproate and Pivanex in the Forced Swim Test: Strain Dependent Outcomes T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40322292; 4406020 JF - 36th Annual Meeting of the Society for Neuroscience AU - Rowe, M AU - Wiest, C AU - Chuang, D Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Histone deacetylase KW - Histones KW - Inhibitors KW - Strains KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40322292?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Histone+Deacetylase+Inhibitors+Valproate+and+Pivanex+in+the+Forced+Swim+Test%3A+Strain+Dependent+Outcomes&rft.au=Rowe%2C+M%3BWiest%2C+C%3BChuang%2C+D&rft.aulast=Rowe&rft.aufirst=M&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hippocampal GluR1 AMPA Receptor Trafficking is Involved in Mood Disorder-Like Behaviors T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40319599; 4406009 JF - 36th Annual Meeting of the Society for Neuroscience AU - Creson, T K AU - Du, J. AU - Chen, G AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Protein transport KW - A-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Mood KW - Glutamic acid receptors (ionotropic) KW - Hippocampus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40319599?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=Hippocampal+GluR1+AMPA+Receptor+Trafficking+is+Involved+in+Mood+Disorder-Like+Behaviors&rft.au=Creson%2C+T+K%3BDu%2C+J.%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Creson&rft.aufirst=T&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - GluR6 Knock-Out Mice Concurrently Display Multiple Behaviors Related to Manic Symptoms T2 - 36th Annual Meeting of the Society for Neuroscience AN - 40316394; 4406008 JF - 36th Annual Meeting of the Society for Neuroscience AU - Shaltiel, G AU - Maeng, S AU - Rogawski, M AU - Gasior, M AU - Chen, G AU - Manji, H K Y1 - 2006/10/14/ PY - 2006 DA - 2006 Oct 14 KW - Mice KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40316394?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.atitle=GluR6+Knock-Out+Mice+Concurrently+Display+Multiple+Behaviors+Related+to+Manic+Symptoms&rft.au=Shaltiel%2C+G%3BMaeng%2C+S%3BRogawski%2C+M%3BGasior%2C+M%3BChen%2C+G%3BManji%2C+H+K&rft.aulast=Shaltiel&rft.aufirst=G&rft.date=2006-10-14&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=36th+Annual+Meeting+of+the+Society+for+Neuroscience&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BD1974E76%2D28AF%2D4C1C% 2D8AE8%2D4F73B56247A7%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Protein kinase C beta and delta isoenzymes mediate cholesterol accumulation in PMA-activated macrophages. AN - 68848788; 16930534 AB - Previously, we showed that PMA activation of human monocyte-derived macrophages stimulates macropinocytosis (i.e., fluid-phase endocytosis) of LDL and transforms these macrophages into foam cells. The current study aimed to learn which PKC isoenzymes mediate cholesterol accumulation in PMA-activated human macrophages incubated with LDL. Cholesterol accumulation by PMA-activated macrophages incubated with LDL was nearly completely inhibited (>85%) by the pan PKC inhibitors Go6850, Go6983, and RO 32-0432, but only was inhibited about 50% by the classical group PKC inhibitor, Go6976. This indicated that cholesterol accumulation was mediated by both a classical group and some other PKC isoenzyme. PKC beta was determined to be the classical group isoenzyme that mediated PMA-stimulated cholesterol accumulation. A pseudosubstrate myristoylated peptide inhibitor of PKC alpha and beta showed partial inhibition (congruent with 50%) of cholesterol accumulation. However, a small molecule inhibitor of PKC alpha, HBDDE, show minimal inhibition of cholesterol accumulation while a small molecule inhibitor of PKC beta, LY333513, could completely account for the inhibition of cholesterol accumulation by the classical group PKC isoenzyme. Thus, our findings show that beta and some other PKC isoenzyme, most likely delta, mediate cholesterol accumulation when macropinocytosis of LDL is stimulated in PMA-activated human monocyte-derived macrophages. JF - Biochemical and biophysical research communications AU - Ma, Hong-Tao AU - Lin, Wan-Wan AU - Zhao, Bin AU - Wu, Wen-Tung AU - Huang, Wei AU - Li, Yifu AU - Jones, Nancy L AU - Kruth, Howard S AD - Section of Experimental Atherosclerosis, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1422, USA. Y1 - 2006/10/13/ PY - 2006 DA - 2006 Oct 13 SP - 214 EP - 220 VL - 349 IS - 1 SN - 0006-291X, 0006-291X KW - Enzyme Inhibitors KW - 0 KW - Isoenzymes KW - Cholesterol KW - 97C5T2UQ7J KW - Protein Kinase C KW - EC 2.7.11.13 KW - Protein Kinase C beta KW - Protein Kinase C-delta KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Atherosclerosis -- pathology KW - Foam Cells -- metabolism KW - Cells, Cultured KW - Humans KW - Monocytes -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Atherosclerosis -- metabolism KW - Models, Biological KW - Signal Transduction KW - Tetradecanoylphorbol Acetate -- metabolism KW - Cholesterol -- metabolism KW - Protein Kinase C -- chemistry KW - Protein Kinase C-delta -- physiology KW - Protein Kinase C -- physiology KW - Protein Kinase C-delta -- chemistry KW - Macrophages -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68848788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+biophysical+research+communications&rft.atitle=Protein+kinase+C+beta+and+delta+isoenzymes+mediate+cholesterol+accumulation+in+PMA-activated+macrophages.&rft.au=Ma%2C+Hong-Tao%3BLin%2C+Wan-Wan%3BZhao%2C+Bin%3BWu%2C+Wen-Tung%3BHuang%2C+Wei%3BLi%2C+Yifu%3BJones%2C+Nancy+L%3BKruth%2C+Howard+S&rft.aulast=Ma&rft.aufirst=Hong-Tao&rft.date=2006-10-13&rft.volume=349&rft.issue=1&rft.spage=214&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+biophysical+research+communications&rft.issn=0006291X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Kinetics of Genes Encoding Innate Host Defense Molecules in Human Monocytes Infected with Rhizopus oryzae T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40254222; 4367446 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Cortez, Karoll J AU - Lyman, Caron A AU - Lempicki, Richard A AU - Ren, Ping AU - Cotten, Catherine AU - Roilides, Emmanuel AU - Kottilil, Shyam AU - Walsh, Thomas J Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Kinetics KW - Monocytes KW - Rhizopus oryzae UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Kinetics+of+Genes+Encoding+Innate+Host+Defense+Molecules+in+Human+Monocytes+Infected+with+Rhizopus+oryzae&rft.au=Cortez%2C+Karoll+J%3BLyman%2C+Caron+A%3BLempicki%2C+Richard+A%3BRen%2C+Ping%3BCotten%2C+Catherine%3BRoilides%2C+Emmanuel%3BKottilil%2C+Shyam%3BWalsh%2C+Thomas+J&rft.aulast=Cortez&rft.aufirst=Karoll&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pathogenesis of Acute HIV Infection T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40252495; 4367793 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Brenchley, Jason Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Infectious diseases KW - Human immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40252495?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Pathogenesis+of+Acute+HIV+Infection&rft.au=Brenchley%2C+Jason&rft.aulast=Brenchley&rft.aufirst=Jason&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Novel Human Pathogen Granulibacter bethesdensis Causes Necrotizing Lymphadenitis in Chronic Granulomatous Disease T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40250358; 4368034 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Greenberg, David E AU - Zelazny, Adrian M AU - Stock, Frida AU - Shoffner, Adam R AU - Wasserman, Richard L AU - Welch, David F AU - Malech, Harry L AU - Murray, Patrick R AU - Holland, Steven M Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Pathogens KW - Chronic granulomatous disease KW - Lymphadenitis KW - Public health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40250358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=The+Novel+Human+Pathogen+Granulibacter+bethesdensis+Causes+Necrotizing+Lymphadenitis+in+Chronic+Granulomatous+Disease&rft.au=Greenberg%2C+David+E%3BZelazny%2C+Adrian+M%3BStock%2C+Frida%3BShoffner%2C+Adam+R%3BWasserman%2C+Richard+L%3BWelch%2C+David+F%3BMalech%2C+Harry+L%3BMurray%2C+Patrick+R%3BHolland%2C+Steven+M&rft.aulast=Greenberg&rft.aufirst=David&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Susceptibility: Understanding Mechanisms of Action of the New Immunomodulating Treatments T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40248500; 4367813 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Holland, Steven Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40248500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Susceptibility%3A+Understanding+Mechanisms+of+Action+of+the+New+Immunomodulating+Treatments&rft.au=Holland%2C+Steven&rft.aulast=Holland&rft.aufirst=Steven&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Infectious Complications of Alemtuzumab and Other Anti-Lymphocytic Agents T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40247343; 4367816 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Gea-Banacloche, Juan Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Disease control UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40247343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Infectious+Complications+of+Alemtuzumab+and+Other+Anti-Lymphocytic+Agents&rft.au=Gea-Banacloche%2C+Juan&rft.aulast=Gea-Banacloche&rft.aufirst=Juan&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Amphotericin B and the Cnundrum of Toxicity vs. Efficacy: How can We Kill More Fungi and Fewer Nephrons? T2 - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AN - 40245788; 4367758 JF - 44th Annual Meeting of the Infectious Diseases Society of America (IDSA 2006) AU - Walsh, Thomas J Y1 - 2006/10/12/ PY - 2006 DA - 2006 Oct 12 KW - Toxicity KW - Fungi KW - Airborne microorganisms KW - Nephrons KW - Amphotericin B KW - Kidneys UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40245788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.atitle=Amphotericin+B+and+the+Cnundrum+of+Toxicity+vs.+Efficacy%3A+How+can+We+Kill+More+Fungi+and+Fewer+Nephrons%3F&rft.au=Walsh%2C+Thomas+J&rft.aulast=Walsh&rft.aufirst=Thomas&rft.date=2006-10-12&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=44th+Annual+Meeting+of+the+Infectious+Diseases+Society+of+America+%28IDSA+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7B5009F758%2DC811%2D4026% 2DADF8%2DA4BBFC12716C%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Polymerizing Actin Positions Primed Integrins along the Leading Edge of Migrating Cells T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40307525; 4398259 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Galbraith, C AU - Yamada, K AU - Galbraith, J Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Actin KW - Integrins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40307525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Polymerizing+Actin+Positions+Primed+Integrins+along+the+Leading+Edge+of+Migrating+Cells&rft.au=Galbraith%2C+C%3BYamada%2C+K%3BGalbraith%2C+J&rft.aulast=Galbraith&rft.aufirst=C&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - SPIO-Labeled Chondrocytes for MRI Evaluation of Cell Distribution in Tissue Engineered Constructs T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40306363; 4398440 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Ramaswamy, S AU - Uluer, M AU - Zhang, Z AU - Spencer, R G Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Magnetic resonance imaging KW - Chondrocytes UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40306363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=SPIO-Labeled+Chondrocytes+for+MRI+Evaluation+of+Cell+Distribution+in+Tissue+Engineered+Constructs&rft.au=Ramaswamy%2C+S%3BUluer%2C+M%3BZhang%2C+Z%3BSpencer%2C+R+G&rft.aulast=Ramaswamy&rft.aufirst=S&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Maximum Likelihood Analysis of Molecular Motor Data T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40303788; 4398574 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Milescu, L S AU - Yildiz, A AU - Selvin, P R AU - Sachs, F Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Motors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40303788?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Maximum+Likelihood+Analysis+of+Molecular+Motor+Data&rft.au=Milescu%2C+L+S%3BYildiz%2C+A%3BSelvin%2C+P+R%3BSachs%2C+F&rft.aulast=Milescu&rft.aufirst=L&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Computational and Experimental Studies of Bursting in Respiratory Neurons T2 - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AN - 40296632; 4397563 JF - 2006 Conference of the Biomedical Engineering Society (BMES 2006) AU - Milescu, L AU - Mogri, M AU - Ptak, K AU - Smith, J Y1 - 2006/10/11/ PY - 2006 DA - 2006 Oct 11 KW - Computational neuroscience KW - Respiration KW - Neurons KW - Metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40296632?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.atitle=Computational+and+Experimental+Studies+of+Bursting+in+Respiratory+Neurons&rft.au=Milescu%2C+L%3BMogri%2C+M%3BPtak%2C+K%3BSmith%2C+J&rft.aulast=Milescu&rft.aufirst=L&rft.date=2006-10-11&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+Biomedical+Engineering+Society+%28BMES+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bme.northwestern.edu/bmes2006/BMES_Prog.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Neuropathy target esterase catalyzes osmoprotective renal synthesis of glycerophosphocholine in response to high NaCl. AN - 68956207; 17015841 AB - Glycerophosphocholine (GPC) is an osmoprotective compatible and counteracting organic osmolyte that accumulates in renal inner medullary cells in response to high NaCl and urea. We previously found that high NaCl increases GPC in renal [Madin-Darby canine kidney (MDCK)] cells. The GPC is derived from phosphatidylcholine, catalyzed by a phospholipase that was not identified at that time. Neuropathy target esterase (NTE) was recently shown to be a phospholipase B that catalyzes production of GPC from phosphatidylcholine. The purpose of the present study was to test whether NTE contributes to the high NaCl-induced increase of GPC synthesis in renal cells. We find that in mouse inner medullary collecting duct cells, high NaCl increases NTE mRNA within 8 h and NTE protein within 16 h. Diisopropyl fluorophosphate, which inhibits NTE esterase activity, reduces GPC accumulation, as does an siRNA that specifically reduces NTE protein abundance. The 20-h half-life of NTE mRNA is unaffected by high NaCl. TonEBP/OREBP is a transcription factor that is activated by high NaCl. Knockdown of TonEBP/OREBP by a specific siRNA inhibits the high NaCl-induced increase of NTE mRNA. Further, the lower renal inner medullary interstitial NaCl concentration that occurs chronically in ClCK1-/- mice and acutely in normal mice given furosemide is associated with lower NTE mRNA and protein. We conclude that high NaCl increases transcription of NTE, likely mediated by TonEBP/OREBP, and that the resultant increase of NTE expression contributes to increased production and accumulation of GPC in mammalian renal cells in tissue culture and in vivo. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Gallazzini, Morgan AU - Ferraris, Joan D AU - Kunin, Margarita AU - Morris, Ryan G AU - Burg, Maurice B AD - Laboratory of Kidney and Electrolyte Metabolism, National Heart Lung and Blood Institute, Department of Health and Human Services, Bethesda, MD 20892-1603, USA. gallazzinim@nhlbi.nih.gov Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15260 EP - 15265 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - Sodium Chloride KW - 451W47IQ8X KW - Glycerylphosphorylcholine KW - 60M22SGW66 KW - Carboxylic Ester Hydrolases KW - EC 3.1.1.- KW - neurotoxic esterase KW - Index Medicus KW - Animals KW - Mice KW - Cell Line KW - Carboxylic Ester Hydrolases -- physiology KW - Glycerylphosphorylcholine -- metabolism KW - Sodium Chloride -- metabolism KW - Kidney -- enzymology KW - Kidney -- cytology KW - Glycerylphosphorylcholine -- biosynthesis KW - Water-Electrolyte Balance -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68956207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Neuropathy+target+esterase+catalyzes+osmoprotective+renal+synthesis+of+glycerophosphocholine+in+response+to+high+NaCl.&rft.au=Gallazzini%2C+Morgan%3BFerraris%2C+Joan+D%3BKunin%2C+Margarita%3BMorris%2C+Ryan+G%3BBurg%2C+Maurice+B&rft.aulast=Gallazzini&rft.aufirst=Morgan&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15260&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Physiol. 1995 Feb;268(2 Pt 1):C402-12 [7864079] J Biol Chem. 1994 Nov 25;269(47):29379-81 [7961914] Int J Biochem Cell Biol. 1995 Oct;27(10):1055-63 [7496995] J Biol Chem. 1996 Aug 2;271(31):18318-21 [8702469] Biochem J. 1998 May 15;332 ( Pt 1):1-4 [9576844] Am J Physiol. 1998 Jun;274(6 Pt 2):F1167-73 [9841510] Nat Genet. 1999 Jan;21(1):95-8 [9916798] Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2538-42 [10051678] J Biol Chem. 1999 Apr 2;274(14):9400-8 [10092620] Nat Biotechnol. 2005 Feb;23(2):222-6 [15619617] J Neurosci. 2005 Mar 16;25(11):2865-73 [15772346] Am J Physiol Renal Physiol. 2005 Sep;289(3):F506-11 [15840767] FEMS Yeast Res. 2006 Mar;6(2):205-17 [16487344] Biochem J. 1999 Dec 15;344 Pt 3:625-31 [10585848] Am J Physiol Renal Physiol. 2000 Feb;278(2):F209-18 [10662725] Biochem Biophys Res Commun. 2000 Apr 2;270(1):52-61 [10733904] J Biol Chem. 2001 Feb 9;276(6):3756-63 [11078727] J Am Soc Nephrol. 2003 Feb;14(2):283-8 [12538727] J Biol Chem. 2003 Mar 7;278(10):8820-5 [12514188] Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5075-80 [15051870] J Biol Chem. 2004 Jun 4;279(23):24024-33 [15044461] Biochem J. 1969 Oct;114(4):711-7 [4310054] Science. 1982 Sep 24;217(4566):1214-22 [7112124] Am J Physiol. 1989 Oct;257(4 Pt 1):C795-801 [2801928] Am J Physiol. 1990 Nov;259(5 Pt 2):F847-58 [2240234] Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7820-4 [1652765] Physiol Rev. 1991 Oct;71(4):1081-115 [1924548] Biochim Biophys Acta. 1993 Jun 5;1148(2):331-41 [8504126] Biochim Biophys Acta. 1993 Jul 25;1150(1):25-34 [8392869] Am J Physiol. 1993 Sep;265(3 Pt 2):F416-24 [8214101] Am J Physiol. 1995 Jul;269(1 Pt 1):C35-41 [7631758] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA. AN - 68955349; 17008406 AB - Nonspecific protein-DNA interactions are inherently dynamic and involve both diffusion of the protein along the DNA and hopping of the protein from one DNA molecule or segment to another. Understanding how gene regulatory proteins interact nonspecifically with DNA in terms of both structure and dynamics is challenging because the experimental observables are an ensemble average of many rapidly exchanging states. By using a variety of NMR spectroscopic techniques, including relaxation analysis, paramagnetic relaxation enhancement, and residual dipolar couplings, we have characterized structural and kinetic aspects of the interaction of the HoxD9 homeodomain with a nonspecific, 24-bp DNA duplex in a system in which the protein is not constrained to any particular site. The data reveal that HoxD9 binds to nonspecific DNA with the same binding mode and orientation as that observed in the specific complex. The mobility, however, of Arg side-chains contacting the DNA is increased in the nonspecific complex relative to the specific one. The kinetics of intermolecular translocation between two different nonspecific DNA molecules have also been analyzed and reveal that at high DNA concentrations (such as those present in vivo) direct transfer from one nonspecific complex to another nonspecific DNA molecule occurs without going through the intermediary of free protein. This finding provides a simple mechanism for accelerating the target search in vivo for the specific site in a sea of nonspecific sites by permitting more effective sampling of available DNA sites as the protein jumps from one segment to another. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Iwahara, Junji AU - Zweckstetter, Markus AU - Clore, G Marius AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15062 EP - 15067 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - HOXD9 protein, human KW - 0 KW - Homeodomain Proteins KW - Neoplasm Proteins KW - Nucleic Acid Heteroduplexes KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Kinetics KW - Humans KW - Neoplasm Proteins -- genetics KW - Protein Binding -- genetics KW - Neoplasm Proteins -- chemistry KW - Neoplasm Proteins -- metabolism KW - Nucleic Acid Heteroduplexes -- genetics KW - Nucleic Acid Heteroduplexes -- metabolism KW - Homeodomain Proteins -- genetics KW - Nuclear Magnetic Resonance, Biomolecular KW - DNA -- metabolism KW - Nucleic Acid Heteroduplexes -- chemistry KW - Homeodomain Proteins -- metabolism KW - DNA -- chemistry KW - Homeodomain Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68955349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=NMR+structural+and+kinetic+characterization+of+a+homeodomain+diffusing+and+hopping+on+nonspecific+DNA.&rft.au=Iwahara%2C+Junji%3BZweckstetter%2C+Markus%3BClore%2C+G+Marius&rft.aulast=Iwahara&rft.aufirst=Junji&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15062&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biomol NMR. 2002 Jun;23(2):127-37 [12153038] J Am Chem Soc. 2002 Apr 24;124(16):4463-72 [11960476] J Am Chem Soc. 2004 May 12;126(18):5879-96 [15125681] Nucleic Acids Res. 2004;32(10):3040-52 [15178741] Biophys J. 2004 Jun;86(6):3444-60 [15189846] Science. 2004 Jul 16;305(5682):386-9 [15256668] J Am Chem Soc. 2004 Oct 13;126(40):12800-8 [15469275] J Biol Chem. 1989 Jan 15;264(2):675-8 [2642903] Proc Natl Acad Sci U S A. 1990 Jun;87(11):4093-7 [1971945] Cell. 1990 Nov 2;63(3):579-90 [1977522] EMBO J. 1993 May;12(5):1781-95 [8491171] Cell. 1994 Jul 29;78(2):211-23 [8044836] Nat Struct Biol. 1995 May;2(5):386-94 [7664096] FEBS Lett. 1996 Dec 2;398(2-3):279-84 [8977123] Trends Biotechnol. 1998 Jan;16(1):22-34 [9470228] J Magn Reson. 1998 Apr;131(2):373-8 [9571116] Nat Struct Biol. 1998 Aug;5(8):692-7 [9699632] J Am Chem Soc. 2005 Apr 27;127(16):5826-32 [15839680] J Am Chem Soc. 2006 Jan 18;128(2):404-5 [16402815] Science. 2006 Feb 24;311(5764):1153-7 [16497933] Nature. 2006 Apr 27;440(7088):1227-30 [16642002] Mol Cell. 2000 May;5(5):889-95 [10882125] J Am Chem Soc. 2002 Jan 23;124(3):372-3 [11792196] Proteins. 2003 Jun 1;51(4):544-51 [12784213] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress. AN - 68945500; 17015825 AB - Alcoholism is a chronic relapsing disorder with substantial heritability. Uncovering gene-environment interactions underlying this disease process can aid identification of novel treatment targets. Here, we found a lowered threshold for stress-induced reinstatement of alcohol seeking in Marchigian-Sardinian Preferring (msP) rats genetically selected for high alcohol preference. In situ hybridization for a panel of 20 stress-related genes in 16 brain regions was used to screen for differential gene expression that may underlie this behavioral phenotype. An innate up-regulation of the Crhr1 transcript, encoding the corticotropin-releasing hormone receptor 1 (CRH-R1), was found in several limbic brain areas of msP rats genetically selected for high alcohol preference, was associated with genetic polymorphism of the Crhr1 promoter, and was accompanied by increased CRH-R1 density. A selective CRH-R1 antagonist (antalarmin, 10-20 mg/kg) was devoid of effects on operant alcohol self-administration in unselected Wistar rats but significantly suppressed this behavior in the msP line. Stress-induced reinstatement of alcohol seeking was not significantly affected by antalarmin in Wistar rats but was fully blocked in msP animals. These data demonstrate that Crhr1 genotype and expression interact with environmental stress to reinstate alcohol-seeking behavior. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Hansson, A C AU - Cippitelli, A AU - Sommer, W H AU - Fedeli, A AU - Björk, K AU - Soverchia, L AU - Terasmaa, A AU - Massi, M AU - Heilig, M AU - Ciccocioppo, R AD - Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10/10/ PY - 2006 DA - 2006 Oct 10 SP - 15236 EP - 15241 VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - CRF receptor type 1 KW - 0 KW - Receptors, Corticotropin-Releasing Hormone KW - Index Medicus KW - Rats KW - Genotype KW - Animals KW - Rats, Mutant Strains KW - Rats, Wistar KW - Behavior, Animal -- physiology KW - Recurrence KW - Male KW - Genetic Variation KW - Stress, Physiological -- psychology KW - Receptors, Corticotropin-Releasing Hormone -- physiology KW - Receptors, Corticotropin-Releasing Hormone -- biosynthesis KW - Stress, Physiological -- genetics KW - Receptors, Corticotropin-Releasing Hormone -- genetics KW - Genetic Predisposition to Disease KW - Alcoholism -- genetics KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68945500?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Variation+at+the+rat+Crhr1+locus+and+sensitivity+to+relapse+into+alcohol+seeking+induced+by+environmental+stress.&rft.au=Hansson%2C+A+C%3BCippitelli%2C+A%3BSommer%2C+W+H%3BFedeli%2C+A%3BBj%C3%B6rk%2C+K%3BSoverchia%2C+L%3BTerasmaa%2C+A%3BMassi%2C+M%3BHeilig%2C+M%3BCiccocioppo%2C+R&rft.aulast=Hansson&rft.aufirst=A&rft.date=2006-10-10&rft.volume=103&rft.issue=41&rft.spage=15236&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuropsychopharmacology. 2002 Sep;27(3):391-9 [12225696] Exp Brain Res. 2001 Jul;139(1):39-52 [11482842] Science. 2002 May 3;296(5569):931-3 [11988580] J Neurosci. 2002 Sep 15;22(18):7856-61 [12223538] Psychopharmacology (Berl). 2003 Jul;168(1-2):3-20 [12402102] J Neurosci. 2003 Jul 9;23(14):6013-22 [12853419] Neuropsychopharmacology. 2003 Aug;28(8):1546-52 [12813472] JAMA. 2004 Mar 10;291(10):1238-45 [15010446] Arch Gen Psychiatry. 2004 Aug;61(8):807-16 [15289279] J Pharmacol Exp Ther. 2004 Nov;311(2):427-40 [15297468] Am Psychol. 1986 Jul;41(7):765-82 [3527003] Physiol Behav. 1995 Jun;57(6):1181-5 [7652041] Psychopharmacology (Berl). 1995 Dec;122(4):369-73 [8657835] Endocrinology. 1996 Dec;137(12):5747-50 [8940412] Neuropsychopharmacology. 1997 Nov;17(5):308-16 [9348546] J Pharmacol Exp Ther. 1998 Jul;286(1):459-68 [9655891] Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9608-13 [9689128] Psychopharmacology (Berl). 1999 May;144(2):151-7 [10394996] Pharmacol Biochem Behav. 2004 Nov;79(3):439-50 [15582015] Pharmacol Biochem Behav. 2004 Dec;79(4):671-89 [15582675] Nat Rev Genet. 2005 Jul;6(7):521-32 [15995696] Nat Neurosci. 2005 Nov;8(11):1431-6 [16251982] Mol Psychiatry. 2006 Jun;11(6):594-602 [16550213] Pharmacol Ther. 2006 Sep;111(3):855-76 [16545872] Addict Biol. 2006 Sep;11(3-4):193-4 [16961757] Addict Biol. 2006 Sep;11(3-4):339-55 [16961763] Alcohol Clin Exp Res. 2002 Oct;26(10):1494-501 [12394282] Neuropsychopharmacology. 2000 Jun;22(6):581-94 [10788758] Am J Psychiatry. 2001 Apr;158(4):582-6 [11282692] FASEB J. 2002 Jan;16(1):27-35 [11772933] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Gastrinomas and CCKomas: Recent Advances T2 - 2006 Benzon Symposia: The New Biology of the Gastrin-Cholecystokinin Family of Hormones AN - 40494539; 4496916 DE: JF - 2006 Benzon Symposia: The New Biology of the Gastrin-Cholecystokinin Family of Hormones AU - Jensen, R T Y1 - 2006/10/09/ PY - 2006 DA - 2006 Oct 09 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40494539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Benzon+Symposia%3A+The+New+Biology+of+the+Gastrin-Cholecystokinin+Family+of+Hormones&rft.atitle=Gastrinomas+and+CCKomas%3A+Recent+Advances&rft.au=Jensen%2C+R+T&rft.aulast=Jensen&rft.aufirst=R&rft.date=2006-10-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Benzon+Symposia%3A+The+New+Biology+of+the+Gastrin-Cholecystokinin+Family+of+Hormones&rft.issn=&rft_id=info:doi/ L2 - http://www.benzon-symposia.dk/sites/abstract53.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Clinical Predictors of Outcome in a Multicentered Randomized Controlled Trial of Whole Body Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy T2 - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AN - 40370588; 4425038 JF - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AU - Shankaran, S Y1 - 2006/10/07/ PY - 2006 DA - 2006 Oct 07 KW - Clinical trials KW - Ischemia KW - Hypothermia KW - Hypoxia KW - Neonates KW - Encephalopathy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40370588?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.atitle=Clinical+Predictors+of+Outcome+in+a+Multicentered+Randomized+Controlled+Trial+of+Whole+Body+Hypothermia+for+Neonatal+Hypoxic-Ischemic+Encephalopathy&rft.au=Shankaran%2C+S&rft.aulast=Shankaran&rft.aufirst=S&rft.date=2006-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/europaediatrics/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Unraveling the Reactions of Nitric Oxide, Nitrite and Hemoglobin in Human Physiology and Therapeutics T2 - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AN - 40369152; 4425158 JF - 2006 Conference of the European Academy of Paediatrics (Europaediatrics 2006) AU - Gladwin, M T Y1 - 2006/10/07/ PY - 2006 DA - 2006 Oct 07 KW - Nitrite KW - Physiology KW - Nitric oxide KW - Hemoglobin KW - Human physiology KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40369152?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.atitle=Unraveling+the+Reactions+of+Nitric+Oxide%2C+Nitrite+and+Hemoglobin+in+Human+Physiology+and+Therapeutics&rft.au=Gladwin%2C+M+T&rft.aulast=Gladwin&rft.aufirst=M&rft.date=2006-10-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Conference+of+the+European+Academy+of+Paediatrics+%28Europaediatrics+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/europaediatrics/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes AN - 19936468; 7079932 AB - Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. Here we report the ability to specifically confer tumor recognition by autologous lymphocytes from peripheral blood by using a retrovirus that encodes a T cell receptor. Adoptive transfer of these transduced cells in 15 patients resulted in durable engraftment at levels exceeding 10% of peripheral blood lymphocytes for at least 2 months after the infusion. We observed high sustained levels of circulating, engineered cells at 1 year after infusion in two patients who both demonstrated objective regression of metastatic melanoma lesions. This study suggests the therapeutic potential of genetically engineered cells for the biologic therapy of cancer. JF - Science (Washington) AU - Morgan, Richard A AU - Dudley, Mark E AU - Wunderlich, John R AU - Hughes, Marybeth S AU - Yang, James C AU - Sherry, Richard M AU - Royal, Richard E AU - Topalian, Suzanne L AU - Kammula, Udai S AU - Restifo, Nicholas P AU - Zheng, Zhili AU - Nahvi, Azam AU - De Vries, Christiaan R AU - Rogers-Freezer, Linda J AU - Mavroukakis, Sharon A AU - Rosenberg, Steven A AD - Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA., SAR@mail.nih.gov Y1 - 2006/10/06/ PY - 2006 DA - 2006 Oct 06 SP - 126 EP - 129 PB - American Association for the Advancement of Science, 1200 New York Avenue, NW Washington DC 20005 USA, [mailto:membership@aaas.org], [URL:http://www.aaas.org] VL - 314 IS - 5796 SN - 0036-8075, 0036-8075 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Immunology Abstracts KW - T-cell receptor KW - Immunotherapy KW - double prime T-cell receptor KW - Peripheral blood KW - Tumors KW - Cancer KW - Melanoma KW - Metastases KW - Retrovirus KW - Genetic engineering KW - Adoptive transfer KW - Lymphocytes T KW - W 30925:Genetic Engineering KW - F 06915:Cancer Immunology KW - G 07730:Development & Cell Cycle KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19936468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Science+%28Washington%29&rft.atitle=Cancer+Regression+in+Patients+After+Transfer+of+Genetically+Engineered+Lymphocytes&rft.au=Morgan%2C+Richard+A%3BDudley%2C+Mark+E%3BWunderlich%2C+John+R%3BHughes%2C+Marybeth+S%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BRoyal%2C+Richard+E%3BTopalian%2C+Suzanne+L%3BKammula%2C+Udai+S%3BRestifo%2C+Nicholas+P%3BZheng%2C+Zhili%3BNahvi%2C+Azam%3BDe+Vries%2C+Christiaan+R%3BRogers-Freezer%2C+Linda+J%3BMavroukakis%2C+Sharon+A%3BRosenberg%2C+Steven+A&rft.aulast=Morgan&rft.aufirst=Richard&rft.date=2006-10-06&rft.volume=314&rft.issue=5796&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=Science+%28Washington%29&rft.issn=00368075&rft_id=info:doi/10.1126%2Fscience.1129003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; T-cell receptor; Retrovirus; double prime T-cell receptor; Immunotherapy; Genetic engineering; Lymphocytes T; Adoptive transfer; Peripheral blood; Tumors; Cancer; Melanoma DO - http://dx.doi.org/10.1126/science.1129003 ER - TY - JOUR T1 - Menopausal hormone therapy and ovarian cancer risk in the National Institutes of Health-AARP Diet and Health Study Cohort. AN - 68928612; 17018786 AB - Recent studies offer conflicting data on risks of ovarian cancer in users of menopausal hormone therapy. Some findings of increased risks associated with unopposed estrogen use are based on older studies of women with intact uteri, and small sample size and incomplete exposure information have limited the data on estrogen plus progestin associations. The National Institutes of Health-AARP Diet and Health Study Cohort included 97,638 women aged 50-71 years at baseline who completed two questionnaires (1995-1996 and 1996-1997). We identified 214 incident ovarian cancers among these women through the year 2000 using data from state cancer registries and mortality indexes. We estimated relative risks (RRs) of ovarian cancer for detailed hormone therapy exposures using multivariable proportional hazards regression models. All statistical tests were two-sided. Use of unopposed estrogen for fewer than 10 years was not associated with ovarian cancer. Compared with use of no hormone therapy, use of unopposed estrogen for 10 or more years was statistically significantly associated with ovarian cancer among all women (RR = 1.89, 95% confidence interval [CI] = 1.22 to 2.95; P = .004; 56 versus 72 ovarian cancers per 100,000 person-years, respectively) and, albeit not statistically significantly, among women with hysterectomy (n = 19,359, RR = 1.70, 95% CI = 0.87 to 3.31; P = .06). Among the 73,483 women with intact uteri, 51,698 had used no hormone therapy or only estrogen plus progestin. Compared with no hormone therapy use, 5 or more years of use of sequential (progestin for or = 15 days per cycle; RR = 1.82, 95% CI = 1.03 to 3.23; P = .02; 49 versus 66 per 100,000 person-years) estrogen plus progestin regimens were statistically significantly associated with ovarian cancer. Long durations of use of unopposed estrogen and of estrogen plus progestin, especially sequential regimens, are associated with increased ovarian cancer risk. These data expand the range of possible risks associated with menopausal hormone therapy. JF - Journal of the National Cancer Institute AU - Lacey, James V AU - Brinton, Louise A AU - Leitzmann, Michael F AU - Mouw, Traci AU - Hollenbeck, Albert AU - Schatzkin, Arthur AU - Hartge, Patricia AD - Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, National Institutes of Health, Rockville, MDUSA. jimlacey@nih.gov Y1 - 2006/10/04/ PY - 2006 DA - 2006 Oct 04 SP - 1397 EP - 1405 VL - 98 IS - 19 KW - Estrogens KW - 0 KW - Progestins KW - Index Medicus KW - Drug Administration Schedule KW - Humans KW - Aged KW - Progestins -- administration & dosage KW - Estrogens -- administration & dosage KW - Risk Assessment KW - Multivariate Analysis KW - Prospective Studies KW - Risk Factors KW - Confounding Factors (Epidemiology) KW - Surveys and Questionnaires KW - Incidence KW - Middle Aged KW - United States -- epidemiology KW - Female KW - Proportional Hazards Models KW - Ovarian Neoplasms -- mortality KW - Estrogen Replacement Therapy -- adverse effects KW - Estrogen Replacement Therapy -- methods KW - Ovarian Neoplasms -- chemically induced KW - Menopause KW - Ovarian Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928612?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Menopausal+hormone+therapy+and+ovarian+cancer+risk+in+the+National+Institutes+of+Health-AARP+Diet+and+Health+Study+Cohort.&rft.au=Lacey%2C+James+V%3BBrinton%2C+Louise+A%3BLeitzmann%2C+Michael+F%3BMouw%2C+Traci%3BHollenbeck%2C+Albert%3BSchatzkin%2C+Arthur%3BHartge%2C+Patricia&rft.aulast=Lacey&rft.aufirst=James&rft.date=2006-10-04&rft.volume=98&rft.issue=19&rft.spage=1397&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-10 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Suicide After Breast Cancer: an International Population-Based Study of 723 810 Women AN - 19358879; 7124595 AB - Few studies have examined long-term suicide risk among breast cancer survivors, and there are no data for women in the United States. We quantified suicide risk through 2002 among 723 810 1-year breast cancer survivors diagnosed between January 1, 1953, and December 31, 2001, and reported to 16 population-based cancer registries in the United States and Scandinavia. Among breast cancer survivors, we calculated standardized mortality ratios (SMRs) and excess absolute risks (EARs) compared with the general population, and the probability of suicide. We used Poisson regression likelihood ratio tests to assess heterogeneity in SMRs; all statistical tests were two-sided, with a .05 cutoff for statistical significance. In total 836 breast cancer patients committed suicide (SMR = 1.37, 95% confidence interval [CI] = 1.28 to 1.47; EAR = 4.1 per 100 000 person-years). Although SMRs ranged from 1.25 to 1.53 among registries, with 245 deaths among the sample of US women (SMR = 1.49, 95% CI = 1.32 to 1.70), differences among registries were not statistically significant (P for heterogeneity = .19). Risk was elevated throughout follow-up, including for 25 or more years after diagnosis (SMR = 1.35, 95% CI = 0.82 to 2.12), and was highest among black women (SMR = 2.88, 95% CI = 1.44 to 5.17) (P for heterogeneity = .06). Risk increased with increasing stage of breast cancer (P for heterogeneity = .08) and remained elevated among women diagnosed between 1990 and 2001 (SMR = 1.36, 95% CI = 1.18 to 1.57). The cumulative probability of suicide was 0.20% 30 years after breast cancer diagnosis. JF - Journal of the National Cancer Institute AU - Schairer, Catherine AU - Brown, Linda Morris AU - Chen, Bingshu E AU - Howard, Regan AU - Lynch, Charles F AU - Hall, Per AU - Storm, Hans AU - Pukkala, Eero AU - Anderson, Aage AU - Kaijser, Magnus AU - Andersson, Michael AU - Joensuu, Heikki AU - Fossaa, Sophie D AU - Ganz, Patricia A AU - Travis, Lois B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD Y1 - 2006/10/04/ PY - 2006 DA - 2006 Oct 04 SP - 1416 EP - 1419 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 19 SN - 0027-8874, 0027-8874 KW - Risk Abstracts KW - Mortality KW - Probability KW - USA KW - Breast cancer KW - Females KW - suicide KW - R2 23110:Psychological aspects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19358879?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Suicide+After+Breast+Cancer%3A+an+International+Population-Based+Study+of+723+810+Women&rft.au=Schairer%2C+Catherine%3BBrown%2C+Linda+Morris%3BChen%2C+Bingshu+E%3BHoward%2C+Regan%3BLynch%2C+Charles+F%3BHall%2C+Per%3BStorm%2C+Hans%3BPukkala%2C+Eero%3BAnderson%2C+Aage%3BKaijser%2C+Magnus%3BAndersson%2C+Michael%3BJoensuu%2C+Heikki%3BFossaa%2C+Sophie+D%3BGanz%2C+Patricia+A%3BTravis%2C+Lois+B&rft.aulast=Schairer&rft.aufirst=Catherine&rft.date=2006-10-04&rft.volume=98&rft.issue=19&rft.spage=1416&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Probability; Mortality; Breast cancer; Females; suicide; USA ER - TY - JOUR T1 - Mathematical modeling of tumor therapy with oncolytic viruses: effects of parametric heterogeneity on cell dynamics. AN - 68987094; 17018145 AB - One of the mechanisms that ensure cancer robustness is tumor heterogeneity, and its effects on tumor cells dynamics have to be taken into account when studying cancer progression. There is no unifying theoretical framework in mathematical modeling of carcinogenesis that would account for parametric heterogeneity. Here we formulate a modeling approach that naturally takes stock of inherent cancer cell heterogeneity and illustrate it with a model of interaction between a tumor and an oncolytic virus. We show that several phenomena that are absent in homogeneous models, such as cancer recurrence, tumor dormancy, and others, appear in heterogeneous setting. We also demonstrate that, within the applied modeling framework, to overcome the adverse effect of tumor cell heterogeneity on the outcome of cancer treatment, a heterogeneous population of an oncolytic virus must be used. Heterogeneity in parameters of the model, such as tumor cell susceptibility to virus infection and the ability of an oncolytic virus to infect tumor cells, can lead to complex, irregular evolution of the tumor. Thus, quasi-chaotic behavior of the tumor-virus system can be caused not only by random perturbations but also by the heterogeneity of the tumor and the virus. The modeling approach described here reveals the importance of tumor cell and virus heterogeneity for the outcome of cancer therapy. It should be straightforward to apply these techniques to mathematical modeling of other types of anticancer therapy. Leonid Hanin (nominated by Arcady Mushegian), Natalia Komarova (nominated by Orly Alter), and David Krakauer. JF - Biology direct AU - Karev, Georgy P AU - Novozhilov, Artem S AU - Koonin, Eugene V AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. karev@ncbi.nlm.nih.gov Y1 - 2006/10/03/ PY - 2006 DA - 2006 Oct 03 SP - 30 VL - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68987094?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+direct&rft.atitle=Mathematical+modeling+of+tumor+therapy+with+oncolytic+viruses%3A+effects+of+parametric+heterogeneity+on+cell+dynamics.&rft.au=Karev%2C+Georgy+P%3BNovozhilov%2C+Artem+S%3BKoonin%2C+Eugene+V&rft.aulast=Karev&rft.aufirst=Georgy&rft.date=2006-10-03&rft.volume=1&rft.issue=&rft.spage=30&rft.isbn=&rft.btitle=&rft.title=Biology+direct&rft.issn=1745-6150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2006-10-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Theor Popul Biol. 1999 Dec;56(3):325-35 [10607525] Nat Med. 1998 Dec;4(12):1341-2 [9846551] Nat Med. 2000 Aug;6(8):879-85 [10932224] J Clin Oncol. 2001 Jan 15;19(2):289-98 [11208818] Cancer Res. 2001 Apr 15;61(8):3501-7 [11309314] Cancer Genet Cytogenet. 2001 Jun;127(2):148-54 [11425455] Hum Gene Ther. 2001 Jul 1;12(10):1323-32 [11440625] Math Biosci. 2002 May-Jun;177-178:73-83 [11965249] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13085-9 [12351679] Cancer Gene Ther. 2002 Dec;9(12):979-86 [12522437] Biochim Biophys Acta. 2003 Aug 22;1622(3):169-78 [12928113] Cancer Biol Ther. 2003 Jul-Aug;2(4 Suppl 1):S157-60 [14508094] Mol Cancer Ther. 2003 Sep;2(9):919-27 [14555711] Cancer Res. 2003 Oct 1;63(19):6212-20 [14559806] Nature. 2003 Nov 13;426(6963):125 [14614483] J Neurooncol. 2003 Dec;65(3):203-26 [14682372] Curr Opin Mol Ther. 2003 Dec;5(6):618-24 [14755888] Nat Rev Cancer. 2004 Mar;4(3):197-205 [14993901] Nat Rev Cancer. 2004 Mar;4(3):227-35 [14993904] Curr Opin Oncol. 2005 Jan;17(1):39-43 [15608511] J Math Biol. 2005 Jul;51(1):37-74 [15772825] Cancer Gene Ther. 2005 Sep;12(9):725-36 [15818382] J Clin Invest. 2005 Jul;115(7):1903-12 [15937544] J Math Biol. 2005 Aug;51(2):123-43 [16012804] Semin Cancer Biol. 2005 Dec;15(6):474-83 [16043360] J Theor Biol. 2006 Feb 21;238(4):841-62 [16153659] Nat Rev Cancer. 2005 Dec;5(12):965-76 [16294217] Curr Gene Ther. 2005 Dec;5(6):595-605 [16457649] Science. 2006 Mar 24;311(5768):1780-4 [16556847] Nat Genet. 2006 Apr;38(4):468-73 [16565718] Cancer Gene Ther. 2006 Nov;13(11):975-92 [16604059] Cancer Res. 1986 May;46(5):2203-7 [3516380] Invasion Metastasis. 1987;7(4):217-29 [3667144] Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1727-33 [526911] Cancer Res. 1984 Jun;44(6):2259-65 [6372991] Cancer Treat Rep. 1984 Jan;68(1):43-61 [6692436] Science. 1984 Jun 1;224(4652):998-1001 [6719130] J Natl Cancer Inst. 1981 Jun;66(6):1037-52 [6941039] Math Biosci. 1995 Jul-Aug;128(1-2):25-40 [7606137] J Theor Biol. 1995 Oct 21;176(4):447-55 [8551743] Mol Med Today. 1996 Dec;2(12):519-27 [9015793] Int Rev Cytol. 1998;177:1-56 [9378615] Cancer Res. 2000 Jan 1;60(1):114-20 [10646862] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. AN - 68925080; 17021379 AB - Amyloid fibrils characterized as highly intractable thread-like species are associated with many neurodegenerative diseases. Although neither the mechanism of amyloid formation nor the origin of amyloid toxicity is currently completely understood, the detailed three-dimensional atomic structures of the yeast protein Sup35 and Abeta amyloid protein determined by recent experiments provide the first and important step towards the comprehension of the pathogenesis and aggregation mechanisms of amyloid diseases. By analyzing these two amyloid peptides which have available crystal structures and other amyloid sequences with proposed structures using computational simulations, we delineate three common features in amyloid organizations and amyloid structures. These could contribute to an improved understanding of the molecular mechanism of amyloid formation, the nature of the aggregation driving forces that stabilize these structures and the development of potential therapeutic agents against amyloid diseases. JF - Physical biology AU - Zheng, Jie AU - Ma, Buyong AU - Nussinov, Ruth AD - Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA. Y1 - 2006/10/03/ PY - 2006 DA - 2006 Oct 03 SP - P1 EP - P4 VL - 3 IS - 3 KW - Amyloid KW - 0 KW - Peptide Termination Factors KW - Prions KW - SUP35 protein, S cerevisiae KW - Saccharomyces cerevisiae Proteins KW - Index Medicus KW - Prions -- chemistry KW - Protein Structure, Secondary KW - Amino Acid Motifs KW - Models, Molecular KW - Humans KW - Crystallography, X-Ray KW - Saccharomyces cerevisiae Proteins -- chemistry KW - Protein Structure, Tertiary KW - Protein Conformation KW - Amyloid -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925080?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+biology&rft.atitle=Consensus+features+in+amyloid+fibrils%3A+sheet-sheet+recognition+via+a+%28polar+or+nonpolar%29+zipper+structure.&rft.au=Zheng%2C+Jie%3BMa%2C+Buyong%3BNussinov%2C+Ruth&rft.aulast=Zheng&rft.aufirst=Jie&rft.date=2006-10-03&rft.volume=3&rft.issue=3&rft.spage=P1&rft.isbn=&rft.btitle=&rft.title=Physical+biology&rft.issn=1478-3975&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-07 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alterations in CNS activity induced by botulinum toxin treatment in spasmodic dysphonia: an H215O PET study. AN - 85398735; pmid-17077220 AB - Speech-related changes in regional cerebral blood flow (rCBF) were measured using H(2)(15)O positron-emission tomography in 9 adults with adductor spasmodic dysphonia (ADSD) before and after botulinum toxin (BTX) injection and 10 age- and gender-matched volunteers without neurological disorders. Scans were acquired at rest and during production of continuous narrative speech and whispered speech. Speech was recorded during scan acquisition for offline quantification of voice breaks, pitch breaks, and percentage aperiodicity to assess correlations between treatment-related changes in rCBF and clinical improvement. Results demonstrated that speech-related responses in heteromodal sensory areas were significantly reduced in persons with ADSD, compared with volunteers, before the administration of BTX. Three to 4 weeks after BTX injection, speech-related responses were significantly augmented in these regions and in left hemisphere motor areas commonly associated with oral-laryngeal motor control. This pattern of responses was most strongly correlated with the objective measures of clinical improvement (decreases in the frequency of voice breaks, pitch breaks, and percentage aperiodicity). These data suggest a pathophysiological model for ADSD in which BTX treatment results in more efficient cortical processing of sensory information, making this information available to motor areas that use it to more effectively regulate laryngeal movements. JF - Journal of speech, language, and hearing research : JSLHR AU - Ali, S Omar AU - Thomassen, Michael AU - Schulz, Geralyn M AU - Hosey, Lara A AU - Varga, Mary AU - Ludlow, Christy L AU - Braun, Allen R AD - Language Section, Voice, Speech and Language Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 10, Room 8S235A, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1127 EP - 1146 VL - 49 IS - 5 SN - 1092-4388, 1092-4388 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - *Anti-Dyskinesia Agents: pharmacology KW - Anti-Dyskinesia Agents: therapeutic use KW - *Botulinum Toxins: pharmacology KW - Botulinum Toxins: therapeutic use KW - *Brain: blood supply KW - Brain: drug effects KW - Brain Mapping KW - Case-Control Studies KW - Female KW - Humans KW - Male KW - Middle Aged KW - Phonetics KW - *Positron-Emission Tomography: methods KW - Regional Blood Flow: drug effects KW - *Speech: drug effects KW - Speech Production Measurement KW - *Voice Disorders: drug therapy KW - Voice Disorders: physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398735?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.atitle=Alterations+in+CNS+activity+induced+by+botulinum+toxin+treatment+in+spasmodic+dysphonia%3A+an+H215O+PET+study.&rft.au=Ali%2C+S+Omar%3BThomassen%2C+Michael%3BSchulz%2C+Geralyn+M%3BHosey%2C+Lara+A%3BVarga%2C+Mary%3BLudlow%2C+Christy+L%3BBraun%2C+Allen+R&rft.aulast=Ali&rft.aufirst=S&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Journal+of+speech%2C+language%2C+and+hearing+research+%3A+JSLHR&rft.issn=10924388&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Patterns of care for adjuvant therapy in a random population-based sample of patients diagnosed with colorectal cancer. AN - 85398154; pmid-17032196 AB - Over the past decade, clinical trials have proved the efficacy of treatments for colorectal cancer (CRC). This study tracks dissemination of these treatments for patients diagnosed with stage II and III disease and compares risk of death for those who received guideline therapy to those who did not.We conducted a stratified randomly sampled, population-based study of CRC treatment trends in the United States. Multivariate models were used to explore patient characteristics associated with receipt of treatments. We pooled data with a previous study-patients diagnosed in 1987-1991 and 1995. Cox proportional hazards models were used to assess observed cause-specific and all-cause mortality.In 2000, guideline therapy receipt decreased among stage III rectal cancer patients, but increased for stage III colon and stage II rectal cancer patients. As age increased, likelihood of receiving guideline treatment decreased (p < 0.0001). Overall, race/ethnicity was significantly associated with guideline therapy (p = 0.04). Rectal patients were less likely to have received guideline treatment. Consistent with randomized clinical trial findings, all-cause mortality was lower in patients who received guideline therapy, regardless of Charlson comorbidity score.Mortality was decreased in patients receiving guideline therapy. Although, rates of guideline-concordant therapy are low in community clinical practice, they are apparently increasing. Newer treatment (oxaliplatin, capecitabine) started to disseminate in 2000. Racial disparities, present in 1995, were not detected in 2000. Age disparities remain despite no evidence of greater chemotherapy-induced toxicity in the elderly. More equitable receipt of cancer treatment to all segments of the community will help to reduce mortality. JF - The American journal of gastroenterology AU - Cronin, Deirdre P AU - Harlan, Linda C AU - Potosky, Arnold L AU - Clegg, Limin X AU - Stevens, Jennifer L AU - Mooney, Margaret M AD - Surveillance Research Program, DCCPS, National Cancer Institute, Bethesda, Maryland, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2308 EP - 2318 VL - 101 IS - 10 SN - 0002-9270, 0002-9270 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - *Antineoplastic Agents: therapeutic use KW - *Colorectal Neoplasms: drug therapy KW - Colorectal Neoplasms: mortality KW - Colorectal Neoplasms: pathology KW - Female KW - *Guideline Adherence: statistics & numerical data KW - Humans KW - Male KW - Middle Aged KW - Neoplasm Staging KW - *Physician's Practice Patterns: statistics & numerical data KW - *Practice Guidelines as Topic KW - *SEER Program KW - United States: epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398154?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+gastroenterology&rft.atitle=Patterns+of+care+for+adjuvant+therapy+in+a+random+population-based+sample+of+patients+diagnosed+with+colorectal+cancer.&rft.au=Cronin%2C+Deirdre+P%3BHarlan%2C+Linda+C%3BPotosky%2C+Arnold+L%3BClegg%2C+Limin+X%3BStevens%2C+Jennifer+L%3BMooney%2C+Margaret+M&rft.aulast=Cronin&rft.aufirst=Deirdre&rft.date=2006-10-01&rft.volume=101&rft.issue=10&rft.spage=2308&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+gastroenterology&rft.issn=00029270&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Direct costs of managing Parkinson's disease in India: concerns in a developing country. AN - 85396823; pmid-16874759 AB - Medicines and surgical interventions improve the quality of life of Parkinson's disease (PD) patients. These are still expensive options and are unaffordable to those living in developing countries. Managing PD in Indians who have a low annual gross national income (GNI; 450-540 US dollars) and for whom only a few (3%) have health insurance is a challenge. We interviewed 175 consecutive PD patients regarding health insurance and money spent for treatment. The annual income of nearly half the patients was less than rupees 50,000 (1,148.63 US dollars). Patients in this study spend nearly 16% to 41.7% of the average Indian GNI to buy medicines. Costs of treating PD in India are lower than those in developed nations but are still out of reach for most Indian patients. JF - Movement disorders : official journal of the Movement Disorder Society AU - Ragothaman, Mona AU - Govindappa, Shyla T AU - Rattihalli, Rohini AU - Subbakrishna, Dodaballapur K AU - Muthane, Uday B AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1755 EP - 1758 VL - 21 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Aged KW - Ambulatory Care: economics KW - Antiparkinson Agents: economics KW - Antiparkinson Agents: therapeutic use KW - Cross-Cultural Comparison KW - *Developing Countries KW - Drug Costs: statistics & numerical data KW - Female KW - Financing, Personal: economics KW - Health Care Costs: statistics & numerical data KW - *Health Expenditures: statistics & numerical data KW - Humans KW - Income: statistics & numerical data KW - India KW - Insurance, Health: economics KW - Male KW - Mathematical Computing KW - Middle Aged KW - Parkinson Disease: drug therapy KW - *Parkinson Disease: economics KW - Prospective Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Direct+costs+of+managing+Parkinson%27s+disease+in+India%3A+concerns+in+a+developing+country.&rft.au=Ragothaman%2C+Mona%3BGovindappa%2C+Shyla+T%3BRattihalli%2C+Rohini%3BSubbakrishna%2C+Dodaballapur+K%3BMuthane%2C+Uday+B&rft.aulast=Ragothaman&rft.aufirst=Mona&rft.date=2006-10-01&rft.volume=21&rft.issue=10&rft.spage=1755&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Effects of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance: comparison of horizontal and 6 degrees head-down bed rest. AN - 85396737; pmid-17165393 AB - This study examined the effect of acute simulated microgravity on nocturnal sleep, daytime vigilance, and psychomotor performance. Each of 7 volunteers were maintained for 3 days of head-down and horizontal bed rest in a counter-balanced design. Assessment measures were polysomnographic recordings on the first night and performance on psychophysiological tasks on the second day involving subjective and objective vigilance, P300, simple reaction time tasks, and dual performance tasks. No clear difference in sleep structure was observed between the head-down and horizontal conditions, except for a slight decrease in Stage 4 for head-down. Both subjective and objective daytime vigilance, P300, and the simple RT task showed no statistical difference, although tracking performance on the dual task showed deterioration at 10:00 for the head-down condition. These results suggest that nocturnal sleep, daytime vigilance, and psychophysiological functions were not disturbed in head-down sleep conditions, although there was a mild deterioration of higher attentional function in the morning. JF - Perceptual and motor skills AU - Komada, Yoko AU - Inoue, Yuichi AU - Mizuno, Koh AU - Tanaka, Hideki AU - Mishima, Kazuo AU - Sato, Hidetomo AU - Shirakawa, Shuichiro AD - Japan Somnology Center, Neuropsychiatric Research Institute, Geriatric Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan. yoko@ncnp-k.go.jp Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 307 EP - 317 VL - 103 IS - 2 SN - 0031-5125, 0031-5125 KW - Index Medicus KW - National Library of Medicine KW - Adult KW - Attention: physiology KW - Bed Rest KW - Cerebral Cortex: physiology KW - Circadian Rhythm: physiology KW - Event-Related Potentials, P300: physiology KW - Fourier Analysis KW - *Head-Down Tilt: physiology KW - Humans KW - Kinesthesis: physiology KW - Male KW - Polysomnography KW - Posture: physiology KW - *Psychomotor Performance: physiology KW - Reaction Time: physiology KW - Signal Processing, Computer-Assisted KW - *Sleep Stages: physiology KW - *Wakefulness: physiology KW - *Weightlessness Simulation: psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Perceptual+and+motor+skills&rft.atitle=Effects+of+acute+simulated+microgravity+on+nocturnal+sleep%2C+daytime+vigilance%2C+and+psychomotor+performance%3A+comparison+of+horizontal+and+6+degrees+head-down+bed+rest.&rft.au=Komada%2C+Yoko%3BInoue%2C+Yuichi%3BMizuno%2C+Koh%3BTanaka%2C+Hideki%3BMishima%2C+Kazuo%3BSato%2C+Hidetomo%3BShirakawa%2C+Shuichiro&rft.aulast=Komada&rft.aufirst=Yoko&rft.date=2006-10-01&rft.volume=103&rft.issue=2&rft.spage=307&rft.isbn=&rft.btitle=&rft.title=Perceptual+and+motor+skills&rft.issn=00315125&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. AN - 85396480; pmid-16795004 AB - Lewy bodies, the pathological hallmark of Parkinson's disease (PD), consist largely of alpha-synuclein, a 14.5-kDa presynaptic neuronal protein implicated in familial PD. An increased copy number and elevated expression of wild-type alpha-synuclein (SNCA) has been shown to cause early-onset familial PD. However, it is not clear whether increased alpha-synuclein expression also plays a role in the pathogenesis of sporadic disease. In the current study, we analyzed the levels of SNCA-mRNA in affected brains of sporadic PD patients. We compared the levels of steady state SNCA-mRNA in 7 sporadic PD brain samples and 7 normal controls using real-time polymerase chain reaction of RNA extracted from mid-brain tissue, including the substantia nigra. Despite that there is neuronal loss in the substantia nigra of PD brains, overall the SNCA-mRNA levels were increased in PD brains an average of nearly fourfold over normal control mid-brain, although there was much greater variability in samples from PD patients compared to controls. Frontal cortex samples from selected individuals were also analyzed. SNCA-mRNA levels were not significantly changed in PD frontal cortex compared to controls. These results suggest that elevated expression levels of SNCA-mRNA are found in the affected regions of PD brain and support the hypothesis that increases in alpha-synuclein expression is associated, among other factors, with the development of sporadic PD. JF - Movement disorders : official journal of the Movement Disorder Society AU - Chiba-Falek, Ornit AU - Lopez, Grisel J AU - Nussbaum, Robert L AD - Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1703 EP - 1708 VL - 21 IS - 10 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - Aged, 80 and over KW - Female KW - Gene Expression: physiology KW - Genetic Predisposition to Disease: genetics KW - Humans KW - Male KW - Mesencephalon: metabolism KW - Parkinson Disease: diagnosis KW - *Parkinson Disease: genetics KW - *RNA, Messenger: genetics KW - Reference Values KW - Substantia Nigra: metabolism KW - *alpha-Synuclein: genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85396480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Levels+of+alpha-synuclein+mRNA+in+sporadic+Parkinson+disease+patients.&rft.au=Chiba-Falek%2C+Ornit%3BLopez%2C+Grisel+J%3BNussbaum%2C+Robert+L&rft.aulast=Chiba-Falek&rft.aufirst=Ornit&rft.date=2006-10-01&rft.volume=21&rft.issue=10&rft.spage=1703&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Comment In: Mov Disord. 2007 May 15;22(7):1057-9; author reply 1057[17373725] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Tiling DNA microarrays for fly genome cartography AN - 762279252; 13696812 AB - Full-genome tiling arrays provide powerful biological evidence to support gene predictions and suggest the need for new and improved annotations. New studies using tiling arrays of the Drosophila melanogaster genome show that 85% of the fly genome is transcribed and processed into mature transcripts, representing 30% of the fly genome. JF - Nature Genetics AU - Oliver, Brian AD - Brian Oliver is in the Laboratory of Cellular and Developmental Biology, US National Institutes of Health, Bethesda, Maryland 20892, USA. oliver[AT]helix.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1101 EP - 1102 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 38 IS - 10 SN - 1061-4036, 1061-4036 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Genomes KW - Drosophila melanogaster KW - DNA microarrays KW - W 30910:Imaging KW - G 07810:Insects KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/762279252?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Genetics&rft.atitle=Tiling+DNA+microarrays+for+fly+genome+cartography&rft.au=Oliver%2C+Brian&rft.aulast=Oliver&rft.aufirst=Brian&rft.date=2006-10-01&rft.volume=38&rft.issue=10&rft.spage=1101&rft.isbn=&rft.btitle=&rft.title=Nature+Genetics&rft.issn=10614036&rft_id=info:doi/10.1038%2Fng1006-1101 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-10-01 N1 - Last updated - 2013-10-04 N1 - SubjectsTermNotLitGenreText - Genomes; DNA microarrays; Drosophila melanogaster DO - http://dx.doi.org/10.1038/ng1006-1101 ER - TY - JOUR T1 - Immunotoxins in the treatment of hematologic malignancies. AN - 69017725; 17073592 AB - Immunotoxins, composed of protein toxins connected to cell binding ligands including monoclonal antibodies and growth factors, have been developed for several decades to target hematologic malignancies. Protein toxins from either plants or bacteria are extremely potent based on their enzymatic inhibition of protein synthesis and induction of apoptosis. Plant toxins, particularly ricin, are useful for chemically conjugating to monoclonal antibodies, and have shown clinical activity in several types of lymphoma and leukemia. Their dose is generally limited by vascular leak syndrome. Bacterial toxins have been used to produce single chain fusions with either growth factors or recombinant antibody fragments. These agents are smaller in size (55-65 kDa) and exit the bloodstream much more rapidly than the chemical conjugates, and generally do not cause severe vascular leak syndrome. The only approved drug containing a protein toxin is denileukin diftitox, a fusion of human interleukin 2 with truncated diphtheria toxin. Denileukin diftitox has shown efficacy in cutaneous T-cell lymphoma, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. Recombinant immunotoxin BL22 is an anti-CD22 Fv fragment fused to truncated Pseudomonas exotoxin; it induces complete remissions in a high percentage of patients with chemoresistant hairy cell leukemia. The anti-CD25 recombinant immunotoxin LMB-2 is active in several CD25+ hematologic malignancies. Several other recombinant immunotoxins are undergoing preclinical development for other target antigens expressed on hematologic malignancies. JF - Current drug targets AU - Kreitman, Robert J AU - Pastan, Ira AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124b, Bethesda, MD 20892-4255, USA. kreitmar@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1301 EP - 1311 VL - 7 IS - 10 KW - Antineoplastic Agents KW - 0 KW - Immunotoxins KW - Index Medicus KW - Animals KW - Humans KW - Hematologic Neoplasms -- drug therapy KW - Immunotoxins -- therapeutic use KW - Hematologic Neoplasms -- immunology KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69017725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+drug+targets&rft.atitle=Immunotoxins+in+the+treatment+of+hematologic+malignancies.&rft.au=Kreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=7&rft.issue=10&rft.spage=1301&rft.isbn=&rft.btitle=&rft.title=Current+drug+targets&rft.issn=1873-5592&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-10-31 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The acute intoxicating effects of ethanol are not dependent on the vasopressin 1a or 1b receptors. AN - 69012575; 17049983 AB - Studies of the role of vasopressin (Avp) in mediating the effects of ethanol have focused on Avp's role in altering kidney function via its action through the vasopressin 2 receptor. However, alcohol consumption also has central effects that are poorly understood. There is evidence that Avp may mediate ethanol consumption as well as some of ethanol's behavioral effects. Centrally only two Avp receptor subtypes are expressed: the 1a receptor (Avpr1a) and the 1b receptor (Avpr1b). To determine the extent to which these receptors mediate the behavioral effects of alcohol, we used mice with targeted disruptions of either their Avpr1a or Avpr1b gene. We examined the effects of genotype on the acute intoxicating effects of ethanol as well as on voluntary ethanol consumption. Surprisingly, our findings indicate that there is no interaction between either the Avpr1a or Avpr1b and ethanol on motor coordination, hypothermia, mood, or voluntary ethanol consumption. JF - Neuropeptides AU - Caldwell, Heather K AU - Stewart, John AU - Wiedholz, Lisa M AU - Millstein, Rachel A AU - Iacangelo, Anna AU - Holmes, Andrew AU - Young, W Scott AU - Wersinger, Scott R AD - Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA. heathercaldwell@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 325 EP - 337 VL - 40 IS - 5 SN - 0143-4179, 0143-4179 KW - Hypnotics and Sedatives KW - 0 KW - Receptors, Vasopressin KW - Index Medicus KW - Animals KW - Anxiety -- psychology KW - Mice KW - Hypnotics and Sedatives -- pharmacology KW - Postural Balance -- drug effects KW - Mice, Knockout KW - Body Temperature Regulation -- drug effects KW - Swimming -- psychology KW - Reflex -- drug effects KW - Alcohol Drinking -- psychology KW - Mice, Inbred C57BL KW - Motor Activity -- drug effects KW - Alcohol Drinking -- genetics KW - Female KW - Male KW - Alcoholic Intoxication -- physiopathology KW - Receptors, Vasopressin -- physiology KW - Receptors, Vasopressin -- genetics KW - Alcoholic Intoxication -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69012575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropeptides&rft.atitle=The+acute+intoxicating+effects+of+ethanol+are+not+dependent+on+the+vasopressin+1a+or+1b+receptors.&rft.au=Caldwell%2C+Heather+K%3BStewart%2C+John%3BWiedholz%2C+Lisa+M%3BMillstein%2C+Rachel+A%3BIacangelo%2C+Anna%3BHolmes%2C+Andrew%3BYoung%2C+W+Scott%3BWersinger%2C+Scott+R&rft.aulast=Caldwell&rft.aufirst=Heather&rft.date=2006-10-01&rft.volume=40&rft.issue=5&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Neuropeptides&rft.issn=01434179&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-04 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic basis of cancer of the kidney. AN - 68968579; 17045083 AB - Kidney cancer is not a single disease. It is made up of a number of different types of cancer that occur in the kidney, each with a different histologic type, having a different clinical course, responding differently to therapy and caused by a different gene. The identification of families with a predisposition to the development of renal neoplasms, including von Hippel-Lindau (VHL), hereditary papillary renal carcinoma (HPRC), Birt-Hogg-Dubé (BHD), and hereditary leiomyomatosis and renal cell cancer (HLRCC), has made possible the identification of the different genes for these cancers. The genetic basis for each of these has been identified with current investigation focusing on the mechanisms of carcinogenesis. The elucidation of molecular pathogenesis in these familial forms of kidney cancer should provide the opportunity to determine successful approaches for novel therapeutic agents. JF - Seminars in oncology AU - Sudarshan, Sunil AU - Linehan, W Marston AD - Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-1107, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 544 EP - 551 VL - 33 IS - 5 SN - 0093-7754, 0093-7754 KW - Index Medicus KW - Syndrome KW - Humans KW - Kidney Neoplasms -- genetics KW - von Hippel-Lindau Disease -- genetics KW - Genetic Predisposition to Disease KW - Carcinoma, Renal Cell -- genetics KW - Carcinoma, Papillary -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968579?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+oncology&rft.atitle=Genetic+basis+of+cancer+of+the+kidney.&rft.au=Sudarshan%2C+Sunil%3BLinehan%2C+W+Marston&rft.aulast=Sudarshan&rft.aufirst=Sunil&rft.date=2006-10-01&rft.volume=33&rft.issue=5&rft.spage=544&rft.isbn=&rft.btitle=&rft.title=Seminars+in+oncology&rft.issn=00937754&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A slow-onset, long-duration indanamine monoamine reuptake inhibitor as a potential maintenance pharmacotherapy for psychostimulant abuse: effects in laboratory rat models relating to addiction. AN - 68967101; 16901516 AB - Slow-onset, long-lasting dopamine reuptake blockers with reduced abuse potential have been suggested as maintenance therapies for cocaine addiction. We have synthesized a series of 3-(3',4'-dichlorophenyl)-1-indanamine monoamine reuptake inhibitors as candidates for such maintenance pharmacotherapy. The initial lead compound, the N,N-dimethyl analogue 30,640 was then subjected to testing in addiction-relevant animal models. Compound 30,640 (2 mg/kg i.p.) produced a pronounced slow-onset, long-lasting increase (300-400%) in extracellular nucleus accumbens dopamine levels, as measured by in vivo brain microdialysis in awake laboratory rats. Slow-onset, long-lasting decreases (40-80%) in the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid, and the serotonin metabolite 5-hydroxyindoleacetic acid were also seen. Compound 30,640 (3 or 5 mg/kg i.p.) also produced a significant (approximately 30%) slow-onset, long-lasting enhancement of electrical brain-stimulation reward, which was additive with that of cocaine (5 mg/kg i.p.). When given to cocaine-administering rats, 30,640 (2.5, 3, 5, or 10 mg/kg i.p.) significantly inhibited (30-60%) intravenous cocaine self-administration, with a pronounced long-lasting profile. In sum, 30,640 showed cocaine-like effects, but with a marked slow-onset, long-lasting profile. We conclude that the prodrug strategy employed in the design of 30,640 achieved its goal. We suggest that such compounds may be useful as maintenance pharmacotherapies for psychostimulant addiction. JF - Neuropharmacology AU - Gardner, Eliot L AU - Liu, Xinhe AU - Paredes, William AU - Giordano, Anthony AU - Spector, Jordan AU - Lepore, Marino AU - Wu, Kuo-Ming AU - Froimowitz, Mark AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Building C - Room 393, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. egardner@intra.nida.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 993 EP - 1003 VL - 51 IS - 5 SN - 0028-3908, 0028-3908 KW - Indans KW - 0 KW - Indenes KW - Neurotransmitter Uptake Inhibitors KW - compound 30,640 KW - 3,4-Dihydroxyphenylacetic Acid KW - 102-32-9 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Drug Interactions KW - Electric Stimulation -- methods KW - Nucleus Accumbens -- drug effects KW - Dose-Response Relationship, Drug KW - Hydroxyindoleacetic Acid -- metabolism KW - Disease Models, Animal KW - Dopamine -- metabolism KW - Homovanillic Acid -- metabolism KW - Behavior, Animal KW - Dialysis -- methods KW - Rats KW - Indenes -- therapeutic use KW - Rats, Sprague-Dawley KW - Self Administration -- methods KW - 3,4-Dihydroxyphenylacetic Acid -- metabolism KW - Nucleus Accumbens -- metabolism KW - Indenes -- chemistry KW - Time Factors KW - Male KW - Indans -- therapeutic use KW - Indans -- chemistry KW - Neurotransmitter Uptake Inhibitors -- pharmacology KW - Substance-Related Disorders -- etiology KW - Substance-Related Disorders -- drug therapy KW - Neurotransmitter Uptake Inhibitors -- therapeutic use KW - Cocaine -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68967101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropharmacology&rft.atitle=A+slow-onset%2C+long-duration+indanamine+monoamine+reuptake+inhibitor+as+a+potential+maintenance+pharmacotherapy+for+psychostimulant+abuse%3A+effects+in+laboratory+rat+models+relating+to+addiction.&rft.au=Gardner%2C+Eliot+L%3BLiu%2C+Xinhe%3BParedes%2C+William%3BGiordano%2C+Anthony%3BSpector%2C+Jordan%3BLepore%2C+Marino%3BWu%2C+Kuo-Ming%3BFroimowitz%2C+Mark&rft.aulast=Gardner&rft.aufirst=Eliot&rft.date=2006-10-01&rft.volume=51&rft.issue=5&rft.spage=993&rft.isbn=&rft.btitle=&rft.title=Neuropharmacology&rft.issn=00283908&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-12 N1 - Date created - 2006-10-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolism of furans in vitro: ipomeanine and 4-ipomeanol. AN - 68964556; 17040101 AB - Ipomeanine (IPN), 4-ipomeanol (4-IPO), 1-ipomeanol (1-IPO), and 1,4-ipomeadiol (DIOL) are toxic 3-substituted furans found in mold-damaged sweet potatoes. IPN and 4-IPO are the most toxic, but all produce pulmonary toxicity in cattle and rodents, and 4-IPO induces hepatotoxicity in humans. These furans require metabolic activation to elicit toxicity, but the limited information obtained from previous metabolism studies prompted us to initiate the investigation reported here. Our initial studies of 4-IPO metabolism by rat liver microsomes demonstrated that the oxidation of 4-IPO to IPN and reduction to DIOL occurred and that more IPN was metabolized to a reactive species than 4-IPO or DIOL. Incubation of IPN and Gly produced a 2'-pyrrolin-5'-one adduct establishing that IPN was metabolized to an enedial. N-Acetylcysteine reacted with the 5'-aldehyde of the enedial to give two 2',5'-dihydro-2'-hydroxyfurans stabilized by H bonding between the 2'-OH and 3'-keto group. Reaction of the enedial metabolite of IPN with one GSH gave several adducts including a pyrrole derived from the 1,2-addition of GSH to the 5'-aldehyde as well as two tricyclic 2'-pyrrolines derived from the 1,4-addition of GSH at the 4'-position. The identities of the pyrrole and 2'-pyrroline GSH adducts were confirmed by observation of structurally similar adducts from Cys conjugation with the enedial metabolite of IPN. Several minor adducts from the conjugation of the enedial metabolite of IPN with two GSH were also detected. Mono-GSH and bis-GSH adducts were derived from both the 1,2-and 1,4-addition of GSH to the enedial metabolite of 4-IPO in rat liver microsomal incubations of 4-IPO and GSH. Sequential oxidation of 4-IPO to IPN and then to the enedial metabolite followed by GSH conjugation also occurred in the 4-IPO incubations. The complex structures of the reaction products of the enedial with biological nucleophiles may explain why the many attempts to identify 4-IPO adducts to protein have not been successful. JF - Chemical research in toxicology AU - Chen, Ling-Jen AU - DeRose, Eugene F AU - Burka, Leo T AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. ferguso2@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1320 EP - 1329 VL - 19 IS - 10 SN - 0893-228X, 0893-228X KW - Furans KW - 0 KW - Terpenes KW - 4-ipomeanol KW - 32954-58-8 KW - ipomeanine KW - 496-06-0 KW - NADP KW - 53-59-8 KW - Glutathione KW - GAN16C9B8O KW - Cysteine KW - K848JZ4886 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Rats KW - Oxidation-Reduction KW - Molecular Structure KW - Animals KW - Acetylation KW - Rats, Inbred F344 KW - Cysteine -- metabolism KW - Microsomes -- metabolism KW - Glycine -- metabolism KW - Glutathione -- metabolism KW - NADP -- metabolism KW - Methylation KW - Furans -- metabolism KW - Furans -- chemistry KW - Terpenes -- metabolism KW - Terpenes -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68964556?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Metabolism+of+furans+in+vitro%3A+ipomeanine+and+4-ipomeanol.&rft.au=Chen%2C+Ling-Jen%3BDeRose%2C+Eugene+F%3BBurka%2C+Leo+T&rft.aulast=Chen&rft.aufirst=Ling-Jen&rft.date=2006-10-01&rft.volume=19&rft.issue=10&rft.spage=1320&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-08 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sensitization of B16 tumor cells with a CXCR4 antagonist increases the efficacy of immunotherapy for established lung metastases. AN - 68960383; 17041104 AB - Expression of the chemokine receptor CXCR4 by tumor cells promotes metastasis, possibly by activating prosurvival signals that render cancer cells resistant to immune attack. Inhibition of CXCR4 with a peptide antagonist, T22, blocks metastatic implantation of CXCR4-transduced B16 (CXCR4-luc-B16) melanoma cells in lung, but not the outgrowth of established metastases, raising the question of how T22 can best be used in a clinical setting. Herein, whereas the treatment of CXCR4-luc-B16 cells in vitro with the CXCR4 ligand CXCL12 did not reduce killing induced by cisplatin or cyclophosphamide, CXCL12 markedly reduced Fas-dependent killing by gp100-specific (pmel-1) CD8(+) T cells. T22 pretreatment restored sensitivity of CXCR4-luc-B16 cells to pmel-1 killing, even in the presence of CXCL12. Two immune-augmenting regimens were used in combination with T22 to treat experimental lung metastases. First, low-dose cyclophosphamide treatment (100 mg/kg) on day 5 in combination with T22 (days 4-7) yielded a approximately 70% reduction of B16 metastatic tumor burden in the lungs compared with cyclophosphamide treatment alone (P < 0.001). Furthermore, whereas anti-CTL antigen 4 (CTLA4) monoclonal antibody (mAb; or T22 treatment) alone had little effect on established B16 metastases, pretreatment with T22 (in combination with anti-CTLA4 mAb) resulted in a 50% reduction in lung tumor burden (P = 0.02). Thus, in vitro, CXCR4 antagonism with T22 renders B16 cells susceptible to killing by antigen-specific T cells. In vivo, T22 synergizes with cyclophosphamide or anti-CTLA4 mAb in the treatment of established lung metastases, suggesting a novel strategy for augmenting the efficacy of immunotherapy. JF - Molecular cancer therapeutics AU - Lee, Chih-Hung AU - Kakinuma, Takashi AU - Wang, Julia AU - Zhang, Hong AU - Palmer, Douglas C AU - Restifo, Nicholas P AU - Hwang, Sam T AD - Dermatology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-1908, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2592 EP - 2599 VL - 5 IS - 10 SN - 1535-7163, 1535-7163 KW - Antibodies, Monoclonal KW - 0 KW - CXCL12 protein, human KW - Chemokine CXCL12 KW - Chemokines, CXC KW - Cxcl12 protein, mouse KW - Peptides KW - Receptors, CXCR4 KW - T22 peptide KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Cyclophosphamide -- administration & dosage KW - Animals KW - Apoptosis KW - Humans KW - Immunotherapy KW - T-Lymphocytes, Cytotoxic -- immunology KW - B-Lymphocytes -- immunology KW - Mice KW - Neoplasm Transplantation KW - Chemokines, CXC -- pharmacology KW - Cytotoxicity, Immunologic KW - Mice, Inbred C57BL KW - Mice, SCID KW - Drug Synergism KW - Female KW - Melanoma, Experimental -- secondary KW - Peptides -- administration & dosage KW - Lung Neoplasms -- immunology KW - Lung Neoplasms -- secondary KW - Lung Neoplasms -- therapy KW - Receptors, CXCR4 -- antagonists & inhibitors KW - Antibodies, Monoclonal -- pharmacology KW - Peptides -- pharmacology KW - Antibodies, Monoclonal -- administration & dosage KW - Melanoma, Experimental -- immunology KW - Melanoma, Experimental -- therapy KW - Peptides -- therapeutic use KW - Receptors, CXCR4 -- immunology KW - Receptors, CXCR4 -- genetics KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68960383?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Sensitization+of+B16+tumor+cells+with+a+CXCR4+antagonist+increases+the+efficacy+of+immunotherapy+for+established+lung+metastases.&rft.au=Lee%2C+Chih-Hung%3BKakinuma%2C+Takashi%3BWang%2C+Julia%3BZhang%2C+Hong%3BPalmer%2C+Douglas+C%3BRestifo%2C+Nicholas+P%3BHwang%2C+Sam+T&rft.aulast=Lee&rft.aufirst=Chih-Hung&rft.date=2006-10-01&rft.volume=5&rft.issue=10&rft.spage=2592&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-30 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat New Biol. 1973 Apr 4;242(118):148-9 [4512654] Exp Dermatol. 2004 Oct;13(10):613-20 [15447721] J Exp Med. 1977 Feb 1;145(2):455-9 [299883] Antimicrob Agents Chemother. 1992 Jun;36(6):1249-55 [1384424] Cancer Res. 1995 Jul 15;55(14):3149-57 [7541714] J Exp Med. 1995 Aug 1;182(2):459-65 [7543139] J Exp Med. 1997 Oct 20;186(8):1383-8 [9334378] J Exp Med. 1997 Oct 20;186(8):1389-93 [9334379] J Virol. 1999 Feb;73(2):1719-23 [9882387] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] Clin Cancer Res. 2005 Mar 1;11(5):1835-41 [15756007] Blood. 2005 Apr 1;105(7):2862-8 [15591121] J Clin Oncol. 2005 Apr 1;23(10):2346-57 [15800326] Oncogene. 2005 Jun 23;24(27):4462-71 [15806155] J Dermatol Sci. 2005 Aug;39(2):105-12 [15899580] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Melanoma Res. 2005 Dec;15(6):543-8 [16314741] J Leukoc Biol. 2006 Apr;79(4):639-51 [16478915] Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13513-8 [14595012] Proc Natl Acad Sci U S A. 1999 Dec 7;96(25):14470-5 [10588729] Nature. 2001 Mar 1;410(6824):50-6 [11242036] J Exp Med. 2001 Aug 20;194(4):481-9 [11514604] J Exp Med. 2001 Sep 17;194(6):823-32 [11560997] J Immunother. 2001 Jul-Aug;24(4):363-73 [11565838] J Biol Chem. 2001 Nov 30;276(48):45098-105 [11571298] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] J Immunol. 2002 Nov 15;169(10):5546-54 [12421931] Cancer Res. 2002 Dec 15;62(24):7328-34 [12499276] Cancer Res. 2003 Jul 1;63(13):3833-9 [12839981] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] Nature. 2003 Sep 18;425(6955):307-11 [13679920] Cancer Res. 2003 Oct 15;63(20):6751-7 [14583470] J Exp Med. 2003 Nov 3;198(9):1337-47 [14581607] Eur J Immunol. 2004 Feb;34(2):336-44 [14768038] Vaccine. 2004 Apr 16;22(13-14):1700-8 [15068853] N Engl J Med. 2004 Apr 1;350(14):1461-3 [15070799] Nat Rev Cancer. 2004 Jul;4(7):540-50 [15229479] Nat Med. 2004 Sep;10(9):909-15 [15340416] J Exp Med. 2004 Sep 20;200(6):771-82 [15381730] Immunology. 1975 May;28(5):939-42 [1132885] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Stem cell transplantation with reduced-intensity conditioning regimens: a review of ten years experience with new transplant concepts and new therapeutic agents. AN - 68959143; 16871277 AB - The realization in the 1990s that allogeneic stem cell transplants (SCT) have a potentially curative graft-versus-leukemia (GVL) effect in addition to the antileukemic action of myeloablative conditioning regimens was a major stimulus for the development of reduced-intensity conditioning (RIC) regimens, aimed primarily at securing engraftment to provide the GVL effect, while minimizing regimen-related toxicity. It is now over 10 years since RIC regimens were heralded as a new direction in the field of SCT. Over the last decade much has been learned about the ways in which the conditioning regimen can be tailored to provide adequate immunosuppression, and modulated to deliver a chosen degree of antimalignant treatment. The huge literature of clinical data with RIC transplantation now permits us to more clearly define the success and limitations of the approach. This review examines the origins of RIC SCT, explores the degree to which the initial expectations and purpose of the approach have been realized, and outlines some ways forward for the field. JF - Leukemia AU - Barrett, A J AU - Savani, B N AD - Hematology Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda MD 20892-1202, USA. barrettj@nhlbi.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1661 EP - 1672 VL - 20 IS - 10 SN - 0887-6924, 0887-6924 KW - Index Medicus KW - Humans KW - Leukemia -- therapy KW - Hematopoietic Stem Cell Transplantation -- trends KW - Transplantation Conditioning -- trends KW - Graft vs Leukemia Effect UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68959143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Leukemia&rft.atitle=Stem+cell+transplantation+with+reduced-intensity+conditioning+regimens%3A+a+review+of+ten+years+experience+with+new+transplant+concepts+and+new+therapeutic+agents.&rft.au=Barrett%2C+A+J%3BSavani%2C+B+N&rft.aulast=Barrett&rft.aufirst=A&rft.date=2006-10-01&rft.volume=20&rft.issue=10&rft.spage=1661&rft.isbn=&rft.btitle=&rft.title=Leukemia&rft.issn=08876924&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-10-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Maternal smoking and testicular germ cell tumors. AN - 68952953; 17035387 AB - Testicular germ cell tumors (TGCT) are the most common cancer among men ages 15 to 35 years in the United States. The well-established TGCT risk factors cryptorchism, prior diagnosis of TGCT, and family history of testicular cancer indicate that exposures in early life and/or in the familial setting may be critical to determining risk. Previous reports of familial clustering of lung cancer in mothers and testicular cancers in sons suggest that passive smoking in childhood may be such an exposure. To clarify the relationship of passive smoking exposure to TGCT risk, data from 754 cases and 928 controls enrolled in the Servicemen's Testicular Tumor Environmental and Endocrine Determinants study were analyzed. Data from 1,086 mothers of the cases and controls were also examined. Overall, there was no relationship between maternal [odds ratio (OR), 1.1; 95% confidence interval (95% CI), 0.9-1.3] or paternal smoking (OR, 1.0; 95% CI, 0.8-1.3) and TGCT risk. Although living with a non-parent smoker was marginally related to risk (OR, 1.4; 95% CI, 1.0-2.1), there was no relationship with number of smokers, amount smoked, or duration of smoking. Responses from both case-control participants and mothers also revealed no relationship between either maternal smoking while pregnant or while breast-feeding. Results did not differ by TGCT histology (seminoma, non-seminoma). These results do not support the hypothesis that passive smoking, either in utero or in childhood, is related to risk of TGCT. Other early life exposures, however, may explain the familial clustering of lung cancer in mothers and TGCT in sons. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - McGlynn, Katherine A AU - Zhang, Yawei AU - Sakoda, Lori C AU - Rubertone, Mark V AU - Erickson, Ralph L AU - Graubard, Barry I AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, MD, USA. mcglynnk@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1820 EP - 1824 VL - 15 IS - 10 SN - 1055-9965, 1055-9965 KW - Tobacco Smoke Pollution KW - 0 KW - Index Medicus KW - Maternal Behavior KW - Seminoma -- etiology KW - Humans KW - Logistic Models KW - Risk Factors KW - Adult KW - Surveys and Questionnaires KW - Case-Control Studies KW - Middle Aged KW - Adolescent KW - Environmental Exposure -- adverse effects KW - Seminoma -- epidemiology KW - United States -- epidemiology KW - Time Factors KW - Female KW - Male KW - Neoplasms, Germ Cell and Embryonal -- etiology KW - Neoplasms, Germ Cell and Embryonal -- epidemiology KW - Mothers -- statistics & numerical data KW - Testicular Neoplasms -- etiology KW - Tobacco Smoke Pollution -- adverse effects KW - Smoking -- adverse effects KW - Testicular Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68952953?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Maternal+smoking+and+testicular+germ+cell+tumors.&rft.au=McGlynn%2C+Katherine+A%3BZhang%2C+Yawei%3BSakoda%2C+Lori+C%3BRubertone%2C+Mark+V%3BErickson%2C+Ralph+L%3BGraubard%2C+Barry+I&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2006-10-01&rft.volume=15&rft.issue=10&rft.spage=1820&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-20 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic basis of murine responses to hyperoxia-induced lung injury. AN - 68950967; 17001473 AB - To evaluate the effect of genetic background on oxygen (O2) toxicity, nine genetically diverse mouse strains (129/SvIm, A/J, BALB/cJ, BTBR+(T)/tf/tf, CAST/Ei, C3H/HeJ, C57BL/6J, DBA/2J, and FVB/NJ) were exposed to more than 99% O2 for 72 h. Immediately following the hyperoxic challenge, the mouse strains demonstrated distinct pathophysiologic responses. The BALB/cJ and CAST/Ei strains, which were the only strains to demonstrate mortality from the hyperoxic challenges, were also the only strains to display significant neutrophil infiltration into their lower respiratory tract. In addition, the O2-challenged BALB/cJ and CAST/Ei mice were among six strains (A/J, BALB/cJ, CAST/Ei, BTBR+(T)/tf/tf, DBA/2J, and C3H/HeJ) that had significantly increased interleukin 6 concentrations in the whole lung lavage fluid and were among all but one strain that had large increases in lung permeability compared with air-exposed controls. In contrast, the DBA/2J strain was the only strain not to have any significant alterations in lung permeability following hyperoxic challenge. The expression of the extracellular matrix proteins, including collagens I, III, and IV, fibronectin I, and tenascin C, also varied markedly among the mouse strains, as did the activities of total superoxide dismutase (SOD) and manganese-SOD (Mn-SOD or SOD2). These data suggest that the response to O2 depends, in part, on the genetic background and that some of the strains analyzed can be used to identify specific loci and genes underlying the response to O2. JF - Immunogenetics AU - Whitehead, Gregory S AU - Burch, Lauranell H AU - Berman, Katherine G AU - Piantadosi, Claude A AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 793 EP - 804 VL - 58 IS - 10 SN - 0093-7711, 0093-7711 KW - Cytokines KW - 0 KW - Extracellular Matrix Proteins KW - Lymphokines KW - neutrophil migration inhibitory factor KW - RNA KW - 63231-63-0 KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - superoxide dismutase 2 KW - Index Medicus KW - Extracellular Matrix Proteins -- analysis KW - Cytokines -- analysis KW - Mice, Inbred Strains KW - Animals KW - Disease Susceptibility KW - Bronchoalveolar Lavage Fluid -- chemistry KW - RNA -- isolation & purification KW - Superoxide Dismutase -- metabolism KW - Mice KW - Species Specificity KW - Male KW - Lung -- immunology KW - Lung Diseases -- genetics KW - Hyperoxia -- pathology KW - Hyperoxia -- genetics KW - Lung Diseases -- pathology KW - Lung -- chemistry KW - Hyperoxia -- metabolism KW - Lung Diseases -- metabolism KW - Lung -- pathology KW - Lung -- metabolism KW - Lung Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68950967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunogenetics&rft.atitle=Genetic+basis+of+murine+responses+to+hyperoxia-induced+lung+injury.&rft.au=Whitehead%2C+Gregory+S%3BBurch%2C+Lauranell+H%3BBerman%2C+Katherine+G%3BPiantadosi%2C+Claude+A%3BSchwartz%2C+David+A&rft.aulast=Whitehead&rft.aufirst=Gregory&rft.date=2006-10-01&rft.volume=58&rft.issue=10&rft.spage=793&rft.isbn=&rft.btitle=&rft.title=Immunogenetics&rft.issn=00937711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-28 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Int J Mol Med. 2001 Jan;7(1):13-9 [11115602] Semin Fetal Neonatal Med. 2005 Jun;10(3):271-82 [15927881] Am J Respir Cell Mol Biol. 2002 Jan;26(1):42-51 [11751202] J Histochem Cytochem. 2002 Mar;50(3):423-31 [11850444] Chest. 2002 Mar;121(3 Suppl):31S-32S [11893671] Am J Physiol Lung Cell Mol Physiol. 2002 Aug;283(2):L246-55 [12114185] J Biol Chem. 2002 Aug 16;277(33):29626-33 [12050154] Semin Neonatol. 2003 Feb;8(1):19-27 [12667827] Free Radic Biol Med. 2004 Mar 15;36(6):782-801 [14990357] Lab Invest. 1969 Jan;20(1):101-18 [4988417] Arch Pathol. 1970 Nov;90(5):463-72 [5476243] Lab Invest. 1978 Dec;39(6):640-53 [739764] Pediatrics. 1980 Jun;65(6):1140-4 [7375238] N Engl J Med. 1980 Jul 10;303(2):76-86 [6247652] Am Rev Respir Dis. 1980 Jul;122(1):123-43 [7406333] J Appl Physiol Respir Environ Exerc Physiol. 1982 May;52(5):1237-44 [7096148] Lab Invest. 1983 Apr;48(4):448-57 [6339811] N Engl J Med. 1983 Oct 13;309(15):878-83 [6888481] Lab Invest. 1985 Apr;52(4):399-408 [2580120] Bull Eur Physiopathol Respir. 1985 Jul-Aug;21(4):325-9 [3899221] Annu Rev Physiol. 1986;48:721-31 [3518622] Annu Rev Cell Biol. 1985;1:67-90 [3916323] Exp Mol Pathol. 1987 Oct;47(2):219-40 [3653349] J Cell Sci Suppl. 1987;8:199-209 [2460476] Am J Pathol. 1990 Aug;137(2):385-92 [1696785] Am J Physiol. 1990 Dec;259(6 Pt 1):L451-8 [2260676] J Appl Physiol (1985). 1991 Dec;71(6):2352-62 [1778933] Am J Respir Cell Mol Biol. 1992 Nov;7(5):548-55 [1419030] J Biol Chem. 1992 Nov 25;267(33):23937-41 [1385428] Pharmacogenetics. 1993 Jun;3(3):135-43 [8334438] Free Radic Biol Med. 1993 May;14(5):531-9 [8349142] Am J Respir Cell Mol Biol. 1995 Oct;13(4):377-86 [7546767] Pediatr Res. 1995 Dec;38(6):857-63 [8618785] Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):511-8 [8756830] Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11853-8 [8876227] Exp Lung Res. 1997 Nov-Dec;23(6):537-52 [9358235] Exp Lung Res. 1998 Mar-Apr;24(2):189-202 [9555576] Am J Physiol. 1998 Jul;275(1 Pt 1):L96-102 [9688940] J Clin Invest. 1999 Apr;103(7):1055-66 [10194479] Minerva Anestesiol. 1999 Jun;65(6):388-92 [10394807] J Biol Chem. 1951 Nov;193(1):265-75 [14907713] Am J Physiol Lung Cell Mol Physiol. 2001 Aug;281(2):L394-402 [11435214] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer incidence among pesticide applicators exposed to dicamba in the agricultural health study. AN - 68948349; 17035136 AB - Dicamba is an herbicide commonly applied to crops in the United States and abroad. We evaluated cancer incidence among pesticide applicators exposed to dicamba in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in North Carolina and Iowa. Detailed pesticide exposure information was obtained through a self-administered questionnaire completed from 1993 to 1997. Cancer incidence was followed through 31 December 2002 by linkage to state cancer registries. We used Poisson regression to estimate rate ratios and 95% confidence intervals for cancer subtypes by tertiles of dicamba exposure. Two dicamba exposure metrics were used: lifetime exposure days and intensity-weighted lifetime exposure days (lifetime days x intensity score). A total of 41,969 applicators were included in the analysis, and 22,036 (52.5%) reported ever using dicamba. Exposure was not associated with overall cancer incidence nor were there strong associations with any specific type of cancer. When the reference group comprised low-exposed applicators, we observed a positive trend in risk between lifetime exposure days and lung cancer (p = 0.02), but none of the individual point estimates was significantly elevated. We also observed significant trends of increasing risk for colon cancer for both lifetime exposure days and intensity-weighted lifetime days, although these results are largely due to elevated risk at the highest exposure level. There was no apparent risk for non-Hodgkin lymphoma. Although associations between exposure and lung and colon cancer were observed, we did not find clear evidence for an association between dicamba exposure and cancer risk. JF - Environmental health perspectives AU - Samanic, Claudine AU - Rusiecki, Jennifer AU - Dosemeci, Mustafa AU - Hou, Lifang AU - Hoppin, Jane A AU - Sandler, Dale P AU - Lubin, Jay AU - Blair, Aaron AU - Alavanja, Michael C R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20852, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1521 EP - 1526 VL - 114 IS - 10 SN - 0091-6765, 0091-6765 KW - Pesticides KW - 0 KW - Dicamba KW - SJG3M6RY6H KW - Index Medicus KW - Registries KW - Humans KW - Adult KW - Incidence KW - Middle Aged KW - North Carolina -- epidemiology KW - Neoplasms -- classification KW - Agricultural Workers' Diseases -- epidemiology KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Dicamba -- toxicity KW - Pesticides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68948349?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Cancer+incidence+among+pesticide+applicators+exposed+to+dicamba+in+the+agricultural+health+study.&rft.au=Samanic%2C+Claudine%3BRusiecki%2C+Jennifer%3BDosemeci%2C+Mustafa%3BHou%2C+Lifang%3BHoppin%2C+Jane+A%3BSandler%2C+Dale+P%3BLubin%2C+Jay%3BBlair%2C+Aaron%3BAlavanja%2C+Michael+C+R&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-10-01&rft.volume=114&rft.issue=10&rft.spage=1521&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-10-12 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Expo Anal Environ Epidemiol. 2002 Sep;12(5):313-8 [12198579] Ann Occup Hyg. 2002 Mar;46(2):245-60 [12074034] J Natl Cancer Inst. 2004 Sep 15;96(18):1375-82 [15367570] Am J Epidemiol. 2004 Nov 1;160(9):876-85 [15496540] Food Cosmet Toxicol. 1965 Aug;3(2):299-304 [5861114] Environ Mol Mutagen. 1990;15(3):131-5 [2331981] Cancer Res. 1990 Oct 15;50(20):6585-91 [2208120] Am J Ind Med. 1990;18(3):295-301 [2220834] Toxicol Lett. 1991 Dec;59(1-3):175-85 [1755024] Cancer Res. 1992 May 1;52(9):2447-55 [1568215] J Toxicol Environ Health. 1992 Oct;37(2):277-91 [1404486] Cancer Causes Control. 1993 Mar;4(2):153-6 [8481493] J Biochem Mol Toxicol. 1998;12(6):339-44 [9736482] Int J Oncol. 1999 Jan;14(1):79-84 [9863012] J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2004 May;22(1):37-55 [15845221] Epidemiology. 2005 Jul;16(4):516-25 [15951670] Toxicol Appl Pharmacol. 1999 Dec 1;161(2):209-18 [10581215] Cancer Epidemiol Biomarkers Prev. 2001 Nov;10(11):1155-63 [11700263] Epidemiology. 2002 Jan;13(1):94-9 [11805592] Nagoya J Med Sci. 2002 Nov;65(3-4):85-94 [12580534] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Exposure to Alternaria alternata in US homes is associated with asthma symptoms. AN - 68940896; 17030243 AB - Exposure to the fungus Alternaria alternata is a risk factor for asthma. Few studies have examined Alternaria exposures in indoor environments. We examined whether exposure to A alternata in US homes was associated with asthma-related outcomes. The data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed a nationally representative sample of 831 housing units inhabited by 2456 individuals in 75 different locations throughout the United States. An interviewer-administered questionnaire obtained information on demographics, household characteristics, and occupants' health status. Exposure to A alternata was assessed by measuring concentrations of A alternata antigens in vacuumed dust samples using a polyclonal anti-A alternata antibody assay. Dust samples were collected from a bed, a sofa, or a chair, and from bedroom, living room, and kitchen floors. Lifetime prevalence of doctor-diagnosed asthma was 11.2%, and 6.9% of the study subjects reported active asthma symptoms in the past 12 months. The prevalence of current symptomatic asthma increased with increasing Alternaria concentrations in US homes; higher levels of A alternata antigens increased the odds of having asthma symptoms in the past year (relative to the lowest tertile, adjusted odds ratio was 1.52, 95% CI, 0.90-2.55 for the 2nd tertile; and 1.84, 95% CI, 1.18-2.85 for the 3rd tertile). Exposure to A alternata in US homes is associated with active asthma symptoms. Measures that reduce indoor exposure to A alternata may help control asthma exacerbations. JF - The Journal of allergy and clinical immunology AU - Salo, Päivi M AU - Arbes, Samuel J AU - Sever, Michelle AU - Jaramillo, Renee AU - Cohn, Richard D AU - London, Stephanie J AU - Zeldin, Darryl C AD - National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 892 EP - 898 VL - 118 IS - 4 SN - 0091-6749, 0091-6749 KW - Antigens, Fungal KW - 0 KW - Dust KW - Abridged Index Medicus KW - Index Medicus KW - Cross-Sectional Studies KW - Housing KW - Dust -- analysis KW - Antigens, Fungal -- immunology KW - Humans KW - Dust -- immunology KW - Antigens, Fungal -- analysis KW - Adult KW - Adolescent KW - Male KW - Female KW - Prevalence KW - Asthma -- epidemiology KW - Air Pollution, Indoor -- adverse effects KW - Environmental Exposure KW - Asthma -- microbiology KW - Alternaria -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68940896?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+allergy+and+clinical+immunology&rft.atitle=Exposure+to+Alternaria+alternata+in+US+homes+is+associated+with+asthma+symptoms.&rft.au=Salo%2C+P%C3%A4ivi+M%3BArbes%2C+Samuel+J%3BSever%2C+Michelle%3BJaramillo%2C+Renee%3BCohn%2C+Richard+D%3BLondon%2C+Stephanie+J%3BZeldin%2C+Darryl+C&rft.aulast=Salo&rft.aufirst=P%C3%A4ivi&rft.date=2006-10-01&rft.volume=118&rft.issue=4&rft.spage=892&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+allergy+and+clinical+immunology&rft.issn=00916749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-10-10 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Allergy Clin Immunol. 1992 Oct;90(4 Pt 1):579-88 [1401641] J Allergy Clin Immunol. 1993 Mar;91(3):773-82 [8454800] N Engl J Med. 1991 Feb 7;324(6):359-63 [1987459] J Allergy Clin Immunol. 1985 Dec;76(6):819-25 [4067131] Clin Exp Allergy. 2004 Oct;34(10):1634-41 [15479281] Clin Microbiol Rev. 1995 Apr;8(2):161-79 [7621398] Am J Respir Crit Care Med. 1997 Apr;155(4):1356-61 [9105079] Environ Health Perspect. 1997 Jun;105(6):622-35 [9288497] Ann Allergy Asthma Immunol. 1998 Mar;80(3):279-85 [9532979] J Allergy Clin Immunol. 1998 May;101(5):626-32 [9600499] Clin Exp Allergy. 1998 Apr;28(4):459-67 [9641573] Clin Exp Allergy. 1998 Apr;28 Suppl 1:2-7; discussion 32-6 [9641582] J Allergy Clin Immunol. 1998 Oct;102(4 Pt 1):563-70 [9802363] Allergy Asthma Proc. 1998 Sep-Oct;19(5):271-5 [9801740] J Allergy Clin Immunol. 1999 Apr;103(4):709-11 [10200024] Clin Exp Allergy. 1999 Nov;29(11):1481-9 [10520075] Ann Allergy Asthma Immunol. 2005 Mar;94(3):313-9; quiz 319-22, 390 [15801241] J Allergy Clin Immunol. 2005 May;115(5):1043-8 [15867864] Indoor Air. 2005;15 Suppl 9:11-9 [15910525] J Allergy Clin Immunol. 2005 Jul;116(1):133-9 [15990786] J Allergy Clin Immunol. 2005 Aug;116(2):377-83 [16083793] J Allergy Clin Immunol. 2005 Sep;116(3):623-9 [16159634] Environ Health Perspect. 2005 Oct;113(10):1405-9 [16203255] J Expo Anal Environ Epidemiol. 1999 Nov-Dec;9(6):560-8 [10638841] Ann Allergy Asthma Immunol. 2000 Jan;84(1):47-54 [10674565] Allergy. 2000 May;55(5):501-4 [10843433] J Allergy Clin Immunol. 2000 Jun;105(6 Pt 1):1185-93 [10856154] Environ Health Perspect. 2000 Aug;108 Suppl 4:653-9 [10931783] Clin Rev Allergy Immunol. 2000 Jun;18(3):285-300 [10981261] Clin Exp Allergy. 2000 Dec;30(12):1733-9 [11122211] J Allergy Clin Immunol. 2001 Mar;107(3 Suppl):S430-40 [11242604] J Allergy Clin Immunol. 2001 Apr;107(4):641-6 [11295652] Ann Allergy Asthma Immunol. 2001 May;86(5):517-23 [11379802] Am J Respir Crit Care Med. 2001 Aug 1;164(3):455-9 [11500349] Appl Environ Microbiol. 2002 Apr;68(4):1743-53 [11916692] Environ Health Perspect. 2002 May;110(5):527-32 [12003758] J Expo Anal Environ Epidemiol. 2002 Nov;12(6):427-32 [12415491] J Allergy Clin Immunol. 2003 Feb;111(2):285-9 [12589346] Pediatr Allergy Immunol. 2003 Apr;14(2):100-5 [12675755] Ann Allergy Asthma Immunol. 2003 Jun;90(6 Suppl 3):7-12 [12839106] J Allergy Clin Immunol. 2004 Feb;113(2):189-98; quiz 199 [14767427] J Allergy Clin Immunol. 2004 Feb;113(2):227-34 [14767434] J Allergy Clin Immunol. 2004 Mar;113(3):388-91 [15007333] J Allergy Clin Immunol. 2004 Sep;114(3):599-606 [15356564] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of raloxifene on bone mineral density in premenopausal women at increased risk of breast cancer. AN - 68939277; 16868059 AB - Raloxifene is a promising breast cancer prevention agent in postmenopausal women at increased risk for breast cancer. The effects of raloxifene in premenopausal women are unknown. We evaluated the effect of raloxifene in premenopausal women at increased risk for breast cancer on bone mineral density (BMD). This was a phase II clinical trial. This study was conducted at an academic medical center. Thirty-seven premenopausal women at increased risk for breast cancer enrolled in the trial. Thirty subjects began treatment and 27 were evaluable. Raloxifene (60 mg daily) and elemental calcium (500 mg daily) were given for 2 yr. Subjects were followed up off medications for 1 yr. The primary end point was the intrasubject percent change in BMD at 1 yr measured by dual-energy x-ray absorptiometry. The mean baseline lumbar spine density was 1.027 g/cm(2). Lumbar spine density decreased 2.3% at 1 yr (P < 0.00001) and 3.5% at 2 yr (P < .00001). Percent change from yr 2 to 3 was +1.4%. The mean baseline total hip bone density was 0.905 g/cm(2). Total hip density decreased 0.3% at 1 yr and 1.0% at 2 yr (P = 0.033). Percent change from yr 2 to 3 was +1.7%. Raloxifene use is associated with a decrease in BMD in premenopausal women at increased risk for breast cancer. The clinical significance of this decrease is unknown and is attenuated with stopping raloxifene. JF - The Journal of clinical endocrinology and metabolism AU - Eng-Wong, J AU - Reynolds, J C AU - Venzon, D AU - Liewehr, D AU - Gantz, S AU - Danforth, D AU - Liu, E T AU - Chow, C AU - Zujewski, J AD - Medical Oncology Clinical Research Unit, National Cancer Institute, Building 10, Room 12N226, 9000 Wisconsin Avenue, Bethesda, MD 20892, USA. engwongj@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 3941 EP - 3946 VL - 91 IS - 10 SN - 0021-972X, 0021-972X KW - Lipids KW - 0 KW - Selective Estrogen Receptor Modulators KW - Raloxifene Hydrochloride KW - 4F86W47BR6 KW - Fibrinogen KW - 9001-32-5 KW - Abridged Index Medicus KW - Index Medicus KW - Lipids -- blood KW - Fibrinogen -- analysis KW - Premenopause KW - Humans KW - Adult KW - Quality of Life KW - Middle Aged KW - Female KW - Bone Density -- drug effects KW - Raloxifene Hydrochloride -- pharmacology KW - Breast Neoplasms -- prevention & control KW - Selective Estrogen Receptor Modulators -- pharmacology KW - Raloxifene Hydrochloride -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68939277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+endocrinology+and+metabolism&rft.atitle=Effect+of+raloxifene+on+bone+mineral+density+in+premenopausal+women+at+increased+risk+of+breast+cancer.&rft.au=Eng-Wong%2C+J%3BReynolds%2C+J+C%3BVenzon%2C+D%3BLiewehr%2C+D%3BGantz%2C+S%3BDanforth%2C+D%3BLiu%2C+E+T%3BChow%2C+C%3BZujewski%2C+J&rft.aulast=Eng-Wong&rft.aufirst=J&rft.date=2006-10-01&rft.volume=91&rft.issue=10&rft.spage=3941&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+endocrinology+and+metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-10-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Endocrinol Metab. 2006 Oct;91(10):3754-6 [17028288] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intralymphatic dendritic cell vaccination induces tumor antigen-specific, skin-homing T lymphocytes. AN - 68930874; 17020987 AB - The identification of tumor antigens recognized by cytotoxic and T helper lymphocytes has led to the development of specific cancer vaccines. Immunization with tumor antigen-pulsed dendritic cells has proved effective at eliciting elevated levels of tumor antigen-specific T cells in patient blood, but objective clinical responses remain rare, suggesting that vaccine-induced T cells are not trafficking optimally to site(s) of tumor burden. Accumulating evidence from animal models suggests that route of immunization can have a substantial influence on the subsequent migration of primed, activated T cells in vivo. In a clinical trial designed to elicit more effective cytotoxic T-cell mediated antitumor responses, metastatic melanoma patients were immunized directly via a peripheral intralymphatic route with autologous dendritic cells pulsed with HLA-A*0201-restricted melanoma-associated peptide antigens derived from MART-1 and gp100. Within 10 days of intralymphatic dendritic cell vaccination, four of six patients developed dramatic and diffuse erythematous rashes in sun-exposed areas of skin that showed extensive T-cell infiltration. CTLs grown from rash biopsies were strongly enriched for tumor antigen-specific T cells that had elevated expression of cutaneous lymphocyte antigen and chemokine receptor-6, consistent with a skin-homing phenotype. Of note, the only patient in the study with cutaneously localized disease showed a significant regression of metastatic lesions following the development of a surrounding rash. The evidence presented here is consistent with immunization studies in animal models and supports the concept that T cells are "imprinted" in peripheral lymph node sites to express specific ligands and chemokine receptors that allow them to migrate to skin. Furthermore, the preferential migration of the T cells to sun-exposed cutaneous sites suggests that inflammation plays a critical role in this migration. These observations suggest that further study of the effects of immunization route and inflammation on T-cell migration in humans is warranted, and could lead to vaccination approaches that would more reliably direct trafficking of activated T cells to diverse sites of metastatic disease. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Grover, Amelia AU - Kim, Grace J AU - Lizée, Gregory AU - Tschoi, Mary AU - Wang, Gang AU - Wunderlich, John R AU - Rosenberg, Steven A AU - Hwang, Sam T AU - Hwu, Patrick AD - Surgery Branch and Dermatology Branch, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 5801 EP - 5808 VL - 12 IS - 19 SN - 1078-0432, 1078-0432 KW - Antigens, Neoplasm KW - 0 KW - Cancer Vaccines KW - HLA-A2 Antigen KW - MART-1 Antigen KW - MLANA protein, human KW - Membrane Glycoproteins KW - Neoplasm Proteins KW - PMEL protein, human KW - gp100 Melanoma Antigen KW - Index Medicus KW - Humans KW - Neoplasm Proteins -- immunology KW - T-Lymphocytes, Cytotoxic -- immunology KW - Vaccination KW - HLA-A2 Antigen -- immunology KW - Cells, Cultured KW - Adult KW - Cytotoxicity Tests, Immunologic KW - Middle Aged KW - Antigens, Neoplasm -- immunology KW - Membrane Glycoproteins -- immunology KW - Female KW - Male KW - Dendritic Cells -- immunology KW - Dendritic Cells -- metabolism KW - Skin Neoplasms -- immunology KW - CD8-Positive T-Lymphocytes -- immunology KW - Melanoma -- secondary KW - Immunotherapy KW - Cancer Vaccines -- therapeutic use KW - Skin Neoplasms -- therapy KW - CD4-Positive T-Lymphocytes -- immunology KW - Melanoma -- therapy KW - Melanoma -- immunology KW - Skin Neoplasms -- secondary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68930874?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Intralymphatic+dendritic+cell+vaccination+induces+tumor+antigen-specific%2C+skin-homing+T+lymphocytes.&rft.au=Grover%2C+Amelia%3BKim%2C+Grace+J%3BLiz%C3%A9e%2C+Gregory%3BTschoi%2C+Mary%3BWang%2C+Gang%3BWunderlich%2C+John+R%3BRosenberg%2C+Steven+A%3BHwang%2C+Sam+T%3BHwu%2C+Patrick&rft.aulast=Grover&rft.aufirst=Amelia&rft.date=2006-10-01&rft.volume=12&rft.issue=19&rft.spage=5801&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Immunol. 1999 Jan 1;162(1):186-94 [9886385] J Exp Med. 1999 May 17;189(10):1631-8 [10330442] Adv Immunol. 1999;72:209-53 [10361577] Cancer Immunol Immunother. 1999 May-Jun;48(2-3):118-22 [10414465] Nature. 1999 Aug 19;400(6746):776-80 [10466728] Science. 1999 Oct 15;286(5439):525-8 [10521347] Eur J Immunol. 2005 Feb;35(2):568-74 [15682446] J Exp Med. 1999 Nov 1;190(9):1241-56 [10544196] Curr Opin Immunol. 2000 Jun;12(3):336-41 [10781407] J Exp Med. 2000 Sep 4;192(5):761-8 [10974041] J Immunol. 2000 Dec 15;165(12):6677-81 [11120783] J Immunol. 2001 Mar 15;166(6):4254-9 [11238679] Cancer Immunol Immunother. 2001 Mar;50(1):3-15 [11315507] Nature. 2001 May 17;411(6835):380-4 [11357146] Cancer Res. 2001 Sep 1;61(17):6451-8 [11522640] J Exp Med. 2001 Nov 19;194(10):1541-7 [11714760] Nat Med. 2002 Feb;8(2):157-65 [11821900] Immunity. 2002 Jan;16(1):1-4 [11825560] Curr Opin Allergy Clin Immunol. 2001 Oct;1(5):461-7 [11964728] Blood. 2002 Dec 1;100(12):3853-60 [12433694] Blood. 2003 Mar 1;101(5):1677-82 [12406880] Blood. 2003 Jul 1;102(1):36-42 [12560234] Nat Immunol. 2004 Jan;5(1):7-10 [14699398] J Immunol. 2004 Jan 15;172(2):857-63 [14707056] Cancer Invest. 2003;21(6):873-86 [14735692] Nat Rev Immunol. 2004 Mar;4(3):211-22 [15039758] Nat Med. 2004 Sep;10(9):909-15 [15340416] Am J Pathol. 1990 May;136(5):1053-68 [1693467] J Invest Dermatol. 1993 Jan;100(1):35S-41S [8423392] J Biol Chem. 1997 Jun 6;272(23):14893-8 [9169459] J Exp Med. 1997 Sep 15;186(6):837-44 [9294138] Nat Med. 1998 Mar;4(3):328-32 [9500607] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. AN - 68930597; 17020984 AB - The DNA methylation paradox, manifested as derepression of cancer-testis antigens, and silencing of tumor suppressors during malignant transformation, provides the rationale for the utilization of chromatin remodeling agents for cancer therapy. A phase I trial was done to examine pharmacokinetics, toxicities, and gene expression mediated by 5-aza-2'-deoxycytidine (DAC) in patients with thoracic malignancies. Thirty-five patients with cancers refractory to standard therapy received continuous 72-hour DAC infusions using a phase I dose-escalation schema. Each full course of therapy consisted of two identical 35-day cycles. Plasma DAC levels were evaluated by liquid chromatography-mass spectrometry techniques. Quantitative reverse transcription-PCR, methylation-specific PCR, and immunohistochemical techniques were used to evaluate NY-ESO-1, MAGE-3, and p16 expression in tumor biopsies. Long oligonucleotide arrays were used to evaluate gene expression profiles in laser-captured tumor cells before and after DAC exposure. Thirty-five patients were evaluable for toxicities; 25 were evaluable for treatment response. Myelosuppression constituted dose-limiting toxicity. The maximum tolerated dose of DAC was 60 to 75 mg/m(2) depending on the number of prior cytotoxic chemotherapy regimens. No objective responses were observed. Plasma DAC concentrations approximated thresholds for gene induction in cultured cancer cells. Target gene induction was observed in 36% of patients. Posttreatment antibodies to NY-ESO-1 were detected in three patients exhibiting NY-ESO-1 induction in their tumor tissues. Complex, heterogeneous gene expression profiles were observed in pretreatment and posttreatment tissues. Prolonged DAC infusions can modulate gene expression in primary thoracic malignancies. These findings support further evaluation of DNA-demethylating agents alone or in combination with other regimens targeting induced gene products for the treatment of these neoplasms. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Schrump, David S AU - Fischette, Maria R AU - Nguyen, Dao M AU - Zhao, Ming AU - Li, Xinmin AU - Kunst, Tricia F AU - Hancox, Ana AU - Hong, Julie A AU - Chen, G Aaron AU - Pishchik, Vitaliy AU - Figg, William D AU - Murgo, Anthony J AU - Steinberg, Seth M AD - Thoracic Oncology Section Surgery Branch, Cancer Therapy Evaluation Program, National Cancer Institute/NIH, 10 Center Drive, Bethesda, MD 20892, USA. davidschrump@nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 5777 EP - 5785 VL - 12 IS - 19 SN - 1078-0432, 1078-0432 KW - Antigens, Neoplasm KW - 0 KW - Antimetabolites, Antineoplastic KW - CTAG1B protein, human KW - MAGEA3 protein, human KW - Membrane Proteins KW - Neoplasm Proteins KW - decitabine KW - 776B62CQ27 KW - DNA Modification Methylases KW - EC 2.1.1.- KW - Azacitidine KW - M801H13NRU KW - Index Medicus KW - Carcinoma, Non-Small-Cell Lung -- metabolism KW - Membrane Proteins -- metabolism KW - Humans KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - DNA Modification Methylases -- antagonists & inhibitors KW - Mesothelioma -- genetics KW - Aged KW - Carcinoma, Squamous Cell -- metabolism KW - Membrane Proteins -- genetics KW - Transcriptional Activation KW - Mesothelioma -- drug therapy KW - Genes, p16 -- physiology KW - Mesothelioma -- metabolism KW - Neoplasm Proteins -- genetics KW - Adult KW - Carcinoma, Squamous Cell -- genetics KW - Antigens, Neoplasm -- metabolism KW - Middle Aged KW - Maximum Tolerated Dose KW - Antigens, Neoplasm -- genetics KW - Neoplasm Proteins -- metabolism KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Male KW - Female KW - Azacitidine -- pharmacology KW - Azacitidine -- analogs & derivatives KW - Lung Neoplasms -- drug therapy KW - Pleural Neoplasms -- genetics KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Antimetabolites, Antineoplastic -- pharmacology KW - Esophageal Neoplasms -- metabolism KW - Esophageal Neoplasms -- genetics KW - Lung Neoplasms -- genetics KW - Pleural Neoplasms -- drug therapy KW - Pleural Neoplasms -- metabolism KW - Esophageal Neoplasms -- drug therapy KW - Lung Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68930597?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Phase+I+study+of+decitabine-mediated+gene+expression+in+patients+with+cancers+involving+the+lungs%2C+esophagus%2C+or+pleura.&rft.au=Schrump%2C+David+S%3BFischette%2C+Maria+R%3BNguyen%2C+Dao+M%3BZhao%2C+Ming%3BLi%2C+Xinmin%3BKunst%2C+Tricia+F%3BHancox%2C+Ana%3BHong%2C+Julie+A%3BChen%2C+G+Aaron%3BPishchik%2C+Vitaliy%3BFigg%2C+William+D%3BMurgo%2C+Anthony+J%3BSteinberg%2C+Seth+M&rft.aulast=Schrump&rft.aufirst=David&rft.date=2006-10-01&rft.volume=12&rft.issue=19&rft.spage=5777&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats. AN - 68929765; 16977594 AB - The cancer bioassay for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) conducted by the Dow Chemical company in the mid 70s has been used extensively for conducting quantitative cancer risk assessments for human exposure to TCDD. More recently the National Toxicology Program (NTP) conducted a cancer bioassay of similar design as part of its evaluation of the dioxin toxic equivalency factor methodology. This report compares the design and the results of these two cancer bioassays. This comparison confirms, in most cases, previously published and widely used carcinogenic response characteristics with respect to dose, time course, organ selectivity, tumor type and maximum intensity of TCDD-induced carcinogenicity and toxicity in the Sprague-Dawley rat. Specifically, increases in the incidences of neoplasms were seen in both studies in the liver, lung and oral mucosa. The most notable difference was the significant increase in the incidence of cholangiocarcinoma of the liver seen in the NTP study but not in the Dow study. The experimental designs for the two studies are similar but some protocol parameters differed, such as vehicle, dosing schedule, diet and rat sub-strain utilized. Differences in the shapes of the dose response curves for several neoplasms were noted between the studies, with the NTP study showing non-linearity for all neoplasms. This may result from differences in the experimental protocols as well as divergence in the biological behavior of the different stocks of Sprague-Dawley rat strains used. JF - Molecular nutrition & food research AU - Walker, Nigel J AU - Wyde, Michael E AU - Fischer, Lawrence J AU - Nyska, Abraham AU - Bucher, John R AD - Environmental Toxicology Program, National Institute of Environmental Health Sciences, Natinal Institutes of Health, Research Triangle Park, NC 27709, USA. walker3@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 934 EP - 944 VL - 50 IS - 10 SN - 1613-4125, 1613-4125 KW - Polychlorinated Dibenzodioxins KW - 0 KW - Index Medicus KW - Rats KW - Mouth Neoplasms -- chemically induced KW - Animals KW - Rats, Sprague-Dawley KW - Hyperplasia KW - Dose-Response Relationship, Drug KW - Kinetics KW - Bile Ducts -- pathology KW - Liver Neoplasms -- chemically induced KW - Lung Neoplasms -- chemically induced KW - Cholangiocarcinoma -- chemically induced KW - Female KW - Polychlorinated Dibenzodioxins -- administration & dosage KW - Neoplasms -- chemically induced KW - Toxicity Tests KW - Polychlorinated Dibenzodioxins -- toxicity KW - Carcinogenicity Tests UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68929765?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+nutrition+%26+food+research&rft.atitle=Comparison+of+chronic+toxicity+and+carcinogenicity+of+2%2C3%2C7%2C8-tetrachlorodibenzo-p-dioxin+%28TCDD%29+in+2-year+bioassays+in+female+Sprague-Dawley+rats.&rft.au=Walker%2C+Nigel+J%3BWyde%2C+Michael+E%3BFischer%2C+Lawrence+J%3BNyska%2C+Abraham%3BBucher%2C+John+R&rft.aulast=Walker&rft.aufirst=Nigel&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=934&rft.isbn=&rft.btitle=&rft.title=Molecular+nutrition+%26+food+research&rft.issn=16134125&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-22 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Toxicology. 2000 Apr 14;145(2-3):103-13 [10771135] J Endocrinol. 1987 Apr;113(1):71-80 [3585227] J Appl Toxicol. 2001 May-Jun;21(3):211-9 [11404832] Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):219-26 [11701191] Toxicol Pathol. 2002 Jan-Feb;30(1):88-92 [11890481] J Toxicol Environ Health A. 2002 Jun 28;65(12):825-42 [12079609] Toxicol Pathol. 2004 Jan-Feb;32(1):41-9 [14713547] Cardiovasc Toxicol. 2003;3(4):299-310 [14734827] Toxicol Appl Pharmacol. 2004 Jan 15;194(2):156-68 [14736496] Environ Health Perspect. 2004 Jun;112(8):903-9 [15175180] Toxicol Pathol. 2004 May-Jun;32(3):333-7 [15204975] Toxicol Appl Pharmacol. 1976 Mar;35(3):553-74 [1265768] Toxicol Appl Pharmacol. 1978 Nov;46(2):279-303 [734660] Toxicol Sci. 2005 May;85(1):594-606 [15716480] Biometrics. 1988 Jun;44(2):417-31 [3390507] Fundam Appl Toxicol. 1989 May;12(4):731-7 [2744275] Regul Toxicol Pharmacol. 1992 Jun;15(3):245-52 [1509118] Prog Clin Biol Res. 1994;387:139-54 [7972244] Toxicol Pathol. 1996 Sep-Oct;24(5):564-72 [8923677] Annu Rev Cell Dev Biol. 1996;12:55-89 [8970722] Toxicol Sci. 2005 Jan;83(1):64-77 [15509667] Environ Health Perspect. 2005 Jan;113(1):43-8 [15626646] Toxicol Pathol. 2005;33(1):165-74 [15805068] Pathology. 2001 May;33(2):130-41 [11358043] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Update on the treatment of lupus nephritis. AN - 68929228; 16929249 AB - Lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus. Although the use of aggressive immunosuppression has improved both patient and renal survival over the past several decades, the optimal treatment of LN remains challenging. Improved outcomes have come at the expense of significant adverse effects owing to therapy. Moreover with long-term survival, the chronic adverse effects of effective therapies including risk of malignancy, atherosclerosis, infertility, and bone disease all become more important. Finally, some patients fail to achieve remission with standard cytotoxic therapy and others relapse when therapy is reduced. For these reasons, recent clinical trials have attempted to define alternate treatment protocols that appear to be efficacious in achieving and maintaining remission, but with less toxicity than standard regimens. This paper discusses established and newer treatment options for patients with proliferative and membranous LN, with an emphasis on the results of these recent clinical trials. We also review the experimental and human data regarding some of the novel targeted forms of therapy that are under investigation and in different phases of clinical trials. JF - Kidney international AU - Waldman, M AU - Appel, G B AD - Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, Maryland 20892, USA. waldmanm@niddk.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1403 EP - 1412 VL - 70 IS - 8 SN - 0085-2538, 0085-2538 KW - Immunologic Factors KW - 0 KW - Immunosuppressive Agents KW - Index Medicus KW - Lupus Erythematosus, Systemic -- immunology KW - Lupus Erythematosus, Systemic -- complications KW - Randomized Controlled Trials as Topic KW - Humans KW - Chemotherapy, Adjuvant KW - Lupus Nephritis -- drug therapy KW - Immunologic Factors -- physiology KW - Lupus Nephritis -- etiology KW - Immunologic Factors -- therapeutic use KW - Lupus Nephritis -- immunology KW - Immunosuppressive Agents -- therapeutic use KW - Immunosuppressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68929228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+international&rft.atitle=Update+on+the+treatment+of+lupus+nephritis.&rft.au=Waldman%2C+M%3BAppel%2C+G+B&rft.aulast=Waldman&rft.aufirst=M&rft.date=2006-10-01&rft.volume=70&rft.issue=8&rft.spage=1403&rft.isbn=&rft.btitle=&rft.title=Kidney+international&rft.issn=00852538&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dietary factors of one-carbon metabolism and prostate cancer risk. AN - 68928900; 17023722 AB - Folate is hypothesized to be inversely associated with the risk of several cancers, but such a potential association has not been well studied for prostate cancer. Vitamin B-6, vitamin B-12, methionine, and alcohol can influence folate-related metabolism. The objective was to investigate the associations between dietary factors of one-carbon metabolism and prostate cancer risk within the alpha-Tocopherol, beta-Carotene Cancer Prevention Study. Of the cohort's 27 111 Finnish male smokers aged 50-69 y who had complete dietary data, 1270 had a diagnosis of incident prostate cancer between 1985 and 2002. Folate, vitamin B-6, vitamin B-12, methionine, and alcohol intakes were estimated from a 276-item modified dietary history questionnaire. Cox proportional hazard models, adjusted for age and vitamin supplement use, estimated relative risks (RR) and 95% CIs. Vitamin B-6 intake was inversely associated with prostate cancer risk (RR for highest versus lowest quintile: 0.88; 95% CI: 0.72, 1.07; P for trend = 0.045), whereas vitamin B-12 intake was associated with significantly increased risk (RR = 1.36; 95% CI: 1.14, 1.96; P for trend = 0.01). No association between folate or alcohol intake and prostate cancer risk was observed. No differences were found in the above associations according to stage of disease or subgroups of several potential effect modifiers. We found no convincing evidence for a protective role of one-carbon metabolism against prostate cancer, although these observations can be generalized only to smokers. The possible modest protective association with vitamin B-6 and the significantly elevated risk with vitamin B-12 intake warrant further investigation. JF - The American journal of clinical nutrition AU - Weinstein, Stephanie J AU - Stolzenberg-Solomon, Rachael AU - Pietinen, Pirjo AU - Taylor, Philip R AU - Virtamo, Jarmo AU - Albanes, Demetrius AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, 20892, USA. weinstes@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 929 EP - 935 VL - 84 IS - 4 SN - 0002-9165, 0002-9165 KW - beta Carotene KW - 01YAE03M7J KW - Ethanol KW - 3K9958V90M KW - Carbon KW - 7440-44-0 KW - Vitamin B 6 KW - 8059-24-3 KW - Folic Acid KW - 935E97BOY8 KW - Methionine KW - AE28F7PNPL KW - One-Carbon Group Transferases KW - EC 2.1.- KW - alpha-Tocopherol KW - H4N855PNZ1 KW - Vitamin B 12 KW - P6YC3EG204 KW - Abridged Index Medicus KW - Index Medicus KW - beta Carotene -- administration & dosage KW - Randomized Controlled Trials as Topic KW - Double-Blind Method KW - Vitamin B 6 -- administration & dosage KW - Humans KW - Ethanol -- administration & dosage KW - Aged KW - Alcohol Drinking KW - One-Carbon Group Transferases -- metabolism KW - Risk Assessment KW - Folic Acid -- administration & dosage KW - Prospective Studies KW - alpha-Tocopherol -- administration & dosage KW - Vitamin B 12 -- adverse effects KW - Risk Factors KW - Case-Control Studies KW - Methionine -- administration & dosage KW - Middle Aged KW - Vitamin B 12 -- administration & dosage KW - Finland -- epidemiology KW - Male KW - Proportional Hazards Models KW - Prostatic Neoplasms -- metabolism KW - Prostatic Neoplasms -- epidemiology KW - Prostatic Neoplasms -- chemically induced KW - Carbon -- metabolism KW - Smoking -- adverse effects KW - Prostatic Neoplasms -- prevention & control KW - Dietary Supplements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68928900?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+clinical+nutrition&rft.atitle=Dietary+factors+of+one-carbon+metabolism+and+prostate+cancer+risk.&rft.au=Weinstein%2C+Stephanie+J%3BStolzenberg-Solomon%2C+Rachael%3BPietinen%2C+Pirjo%3BTaylor%2C+Philip+R%3BVirtamo%2C+Jarmo%3BAlbanes%2C+Demetrius&rft.aulast=Weinstein&rft.aufirst=Stephanie&rft.date=2006-10-01&rft.volume=84&rft.issue=4&rft.spage=929&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+clinical+nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential effects between maotai and ethanol on hepatic gene expression in mice: Possible role of metallothionein and heme oxygenase-1 induction by maotai. AN - 68924744; 17018877 AB - Alcohol is a risk factor for liver fibrosis and hepatocellular carcinoma. On the other hand, light alcoholic beverage consumption is believed to be beneficial because of the effects of both alcohol and nonalcoholic components of the beverage. Maotai is a commonly consumed beverage in China containing 53% alcohol. Epidemiological and experimental studies show that Maotai is less toxic to the liver than ethanol alone. To examine the differential effects of Maotai and ethanol, a low dose of Maotai or an equal amount of ethanol (53%, v/v in water, 5 ml/kg) were given to male mice daily for 1 week, and hepatic RNA was extracted for microarray analysis. Approximately 10% of genes on the liver-selective custom array (588 genes) were altered following Maotai or ethanol administration, but Maotai treated livers had fewer alterations compared with ethanol alone. Real-time reverse transcription-polymerase chain reaction confirmed and extended microarray results on selected genes. An induction of metallothionein and heme oxygenase-1 occurred with Maotai, which could not be explained by alcohol consumption alone, whereas the attenuation of ethanol responsive genes such as quinone dehydrogenase, DNA-ligase 1, IGFBP1, and IL-1beta suggests less liver injury occurred with Maotai. The expression of genes related to liver fibrosis, such as cytokeratin-18, was slightly increased by the high dose of ethanol, but was unchanged in the Maotai group. In summary, gene expression analysis indicates that Maotai induces a different response than ethanol alone. The dramatic induction of metallothionein and heme oxygenase-1 with Maotai could be important adaptive responses to reduce alcoholic liver injury. JF - Experimental biology and medicine (Maywood, N.J.) AU - Liu, Jie AU - Cheng, Min-Liang AU - Shi, Jin-Zheng AU - Yang, Qin AU - Wu, Jun AU - Li, Cheng-Xiu AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, Research Triangle Park, North Carolina, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1535 EP - 1541 VL - 231 IS - 9 SN - 1535-3702, 1535-3702 KW - DNA Primers KW - 0 KW - Ethanol KW - 3K9958V90M KW - Metallothionein KW - 9038-94-2 KW - Heme Oxygenase (Decyclizing) KW - EC 1.14.14.18 KW - Index Medicus KW - Animals KW - Base Sequence KW - Oligonucleotide Array Sequence Analysis KW - Enzyme Induction KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction KW - Gene Expression -- drug effects KW - Liver -- enzymology KW - Heme Oxygenase (Decyclizing) -- biosynthesis KW - Beverages KW - Liver -- drug effects KW - Ethanol -- pharmacology KW - Metallothionein -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68924744?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.atitle=Differential+effects+between+maotai+and+ethanol+on+hepatic+gene+expression+in+mice%3A+Possible+role+of+metallothionein+and+heme+oxygenase-1+induction+by+maotai.&rft.au=Liu%2C+Jie%3BCheng%2C+Min-Liang%3BShi%2C+Jin-Zheng%3BYang%2C+Qin%3BWu%2C+Jun%3BLi%2C+Cheng-Xiu%3BWaalkes%2C+Michael+P&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-10-01&rft.volume=231&rft.issue=9&rft.spage=1535&rft.isbn=&rft.btitle=&rft.title=Experimental+biology+and+medicine+%28Maywood%2C+N.J.%29&rft.issn=15353702&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-25 N1 - Date created - 2006-10-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antidepressant efficacy of the antimuscarinic drug scopolamine: a randomized, placebo-controlled clinical trial. AN - 68924004; 17015814 AB - The need for improved therapeutic agents that more quickly and effectively treat depression is critical. In a pilot study we evaluated the role of the cholinergic system in cognitive symptoms of depression and unexpectedly observed rapid reductions in depression severity following the administration of the antimuscarinic drug scopolamine hydrobromide (4 microg/kg intravenously) compared with placebo (P = .002). Subsequently a clinical trial was designed to assess more specifically the antidepressant efficacy of scopolamine. To evaluate scopolamine as a potential antidepressant agent. Two studies were conducted: a double-blind, placebo-controlled, dose-finding study followed by a double-blind, placebo-controlled, crossover clinical trial. The National Institute of Mental Health. Patients Currently depressed outpatients aged 18 to 50 years meeting DSM-IV criteria for recurrent major depressive disorder or bipolar disorder. Of 39 eligible patients, 19 were randomized and 18 completed the trial. Multiple sessions including intravenous infusions of placebo or scopolamine hydrobromide (4 microg/kg). Individuals were randomized to a placebo/scopolamine or scopolamine/placebo sequence (series of 3 placebo sessions and series of 3 scopolamine sessions). Sessions occurred 3 to 5 days apart. Psychiatric evaluations using the Montgomery-Asberg Depression Rating Scale and the Hamilton Anxiety Rating Scale were performed to assess antidepressant and antianxiety responses to scopolamine. The placebo/scopolamine group showed no significant change during placebo infusion vs baseline; reductions in depression and anxiety rating scale scores (P<.001 for both) were observed after the administration of scopolamine compared with placebo. The scopolamine/placebo group also showed reductions in depression and anxiety rating scale scores (P<.001 for both) after the administration of scopolamine, relative to baseline, and these effects persisted as they received placebo. In both groups, improvement was significant at the first evaluation after scopolamine administration (P< or =.002). Rapid, robust antidepressant responses to the antimuscarinic scopolamine occurred in currently depressed patients who predominantly had poor prognoses. JF - Archives of general psychiatry AU - Furey, Maura L AU - Drevets, Wayne C AD - Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA. mfurey@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1121 EP - 1129 VL - 63 IS - 10 SN - 0003-990X, 0003-990X KW - Antidepressive Agents KW - 0 KW - Muscarinic Antagonists KW - Placebos KW - Scopolamine Hydrobromide KW - 451IFR0GXB KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Depressive Disorder, Major -- drug therapy KW - Psychiatric Status Rating Scales KW - Infusions, Intravenous KW - Double-Blind Method KW - Humans KW - Depressive Disorder, Major -- psychology KW - Bipolar Disorder -- drug therapy KW - Adult KW - Treatment Outcome KW - Bipolar Disorder -- psychology KW - Pilot Projects KW - Research Design KW - Male KW - Female KW - Scopolamine Hydrobromide -- adverse effects KW - Muscarinic Antagonists -- therapeutic use KW - Scopolamine Hydrobromide -- administration & dosage KW - Muscarinic Antagonists -- adverse effects KW - Muscarinic Antagonists -- administration & dosage KW - Antidepressive Agents -- administration & dosage KW - Depressive Disorder -- psychology KW - Depressive Disorder -- drug therapy KW - Antidepressive Agents -- therapeutic use KW - Scopolamine Hydrobromide -- therapeutic use KW - Antidepressive Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68924004?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=Antidepressant+efficacy+of+the+antimuscarinic+drug+scopolamine%3A+a+randomized%2C+placebo-controlled+clinical+trial.&rft.au=Furey%2C+Maura+L%3BDrevets%2C+Wayne+C&rft.aulast=Furey&rft.aufirst=Maura&rft.date=2006-10-01&rft.volume=63&rft.issue=10&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacopsychiatry. 1996 Jan;29(1):23-6 [8852530] Psychosom Med. 1974 May-Jun;36(3):248-57 [4829619] Br J Med Psychol. 1959;32(1):50-5 [13638508] J Clin Psychiatry. 2004;65 Suppl 15:15-20 [15554791] J Psychiatr Res. 2005 Mar;39(2):145-50 [15589562] Biochem Biophys Res Commun. 2006 Feb 10;340(2):435-40 [16376302] J Physiol. 2006 Feb 1;570(Pt 3):553-65 [16322058] Nature. 1977 Apr 21;266(5604):730-2 [559941] J Affect Disord. 1999 Oct;55(2-3):149-57 [10628884] Psychiatry Res. 1999 Dec 13;89(1):1-20 [10643873] Biol Psychiatry. 2000 Feb 15;47(4):351-4 [10686270] J Clin Psychopharmacol. 2000 Aug;20(4):417-22 [10917402] J Clin Pharmacol. 2001 Jan;41(1):51-60 [11144994] Br J Psychiatry. 2001 Mar;178:234-41 [11230034] Depress Anxiety. 1998;7 Suppl 1:11-7 [9597346] Arch Gen Psychiatry. 1978 Jan;35(1):119-22 [339869] Br J Psychiatry. 1978 Nov;133:429-35 [728692] J Psychiatr Res. 1979;15(1):21-40 [219193] Nature. 1979 Sep 13;281(5727):148-50 [471061] Eur J Pharmacol. 1979 Oct 1;58(3):331-4 [510364] Psychiatry Res. 1979 Jul;1(1):17-22 [233154] J Clin Psychiatry. 1981 Aug;42(8):307-12 [7251567] J Clin Psychopharmacol. 1981 Jan;1(1):14-20 [6117578] J Clin Psychopharmacol. 1981 Jul;1(4):186-92 [7028800] Physiol Behav. 1982 Feb;28(2):307-11 [7079344] Mayo Clin Proc. 1983 Jan;58(1):40-6 [6130192] Psychiatry Res. 1983 Jul;9(3):191-200 [6312479] J Clin Psychiatry. 1983 Sep;44(9 Pt 2):4-9 [6313632] Psychopharmacology Suppl. 1985;2:9-18 [2860665] Am J Psychiatry. 1985 Jun;142(6):738-40 [4003595] Biol Psychiatry. 1986 Jul;21(8-9):813-29 [3015271] Psychopharmacology (Berl). 1988;94(2):147-60 [3127840] Arch Gen Psychiatry. 1988 Oct;45(10):906-12 [3048225] Arch Gen Psychiatry. 1989 Jan;46(1):29-35 [2642691] Arch Gen Psychiatry. 1989 May;46(5):421-8 [2712660] Neuropsychopharmacology. 1991 Feb;4(2):125-30 [2025378] Biol Psychiatry. 1991 Jul 15;30(2):157-69 [1655072] Neuropsychopharmacology. 1992 Nov;7(3):197-204 [1388644] Life Sci. 1993;52(12):1023-9 [8445992] Neurosci Biobehav Rev. 1993 Spring;17(1):51-68 [8455816] Biochem Pharmacol. 1993 Jun 9;45(11):2352-4 [8100134] J Psychiatr Res. 1994 May-Jun;28(3):195-210 [7932282] Psychopharmacology (Berl). 1994 May;114(4):559-65 [7855217] Psychopharmacology (Berl). 1995 Jun;119(4):440-8 [7480524] J Clin Psychiatry. 2001;62 Suppl 16:5-9 [11480882] J Clin Psychiatry. 2001;62 Suppl 16:10-7 [11480879] Am J Psychiatry. 2001 Nov;158(11):1843-9 [11691690] Mol Psychiatry. 2002;7 Suppl 1:S71-80 [11986998] Am J Med Genet. 2002 Jul 8;114(5):527-9 [12116189] J Psychiatry Neurosci. 2002 Jul;27(4):250-7 [12174734] Int Clin Psychopharmacol. 2002 Nov;17(6):281-5 [12409681] Ann N Y Acad Sci. 2003 Nov;1003:250-72 [14684451] Sheng Li Xue Bao. 2004 Feb 25;56(1):95-100 [14985837] J Clin Psychiatry. 2004;65 Suppl 4:25-30 [15046538] Curr Med Chem. 2004 Apr;11(7):925-43 [15078174] Hum Mol Genet. 2004 Sep 1;13(17):1903-11 [15229186] Lancet. 1972 Jun 3;1(7762):1236-7 [4113219] Lancet. 1972 Sep 23;2(7778):632-5 [4116781] Comment In: Curr Psychiatry Rep. 2007 Dec;9(6):447-8 [18221623] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CXCR2 ligands and G-CSF mediate PKCalpha-induced intraepidermal inflammation. AN - 68919258; 16964312 AB - Transgenic mice overexpressing PKCalpha in the epidermis (K5-PKCalpha mice) exhibit an inducible severe intraepidermal neutrophilic inflammation and systemic neutrophilia when PKCalpha is activated by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This inducible model of cutaneous inflammation was used to define mediators of skin inflammation that may have clinical relevance. Activation of cutaneous PKCalpha increased the production of the chemotactic factors cytokine-induced neutrophil chemoattractant (KC) and macrophage inflammatory protein 2 (MIP-2) in murine plasma. TPA treatment of cultured K5-PKCalpha keratinocytes also released KC and MIP-2 into culture supernatants through an NF-kappaB-dependent pathway. MIP-2 and KC mediated the infiltration of neutrophils into the epidermis, since this was prevented by ablating CXCR2 in K5-PKCalpha mice or administering neutralizing antibodies against KC or MIP-2. The neutrophilia resulted from PKCalpha-mediated upregulation of cutaneous G-CSF released into the plasma independent of CXCR2. These responses could be inhibited by topical treatment with a PKCalpha-selective inhibitor. Inhibiting PKCalpha also reduced the basal and TNF-alpha- or TPA-induced expression of CXCL8 in cultured psoriatic keratinocytes, suggesting that PKCalpha activity may contribute to psoriatic inflammation. Thus, skin can be the source of circulating factors that have both local and systemic consequences, and these factors, their receptors, and possibly PKCalpha could be therapeutic targets for inhibition of cutaneous inflammation. JF - The Journal of clinical investigation AU - Cataisson, Christophe AU - Pearson, Andrea J AU - Tsien, Margaret Z AU - Mascia, Francesca AU - Gao, Ji-Liang AU - Pastore, Saveria AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2757 EP - 2766 VL - 116 IS - 10 SN - 0021-9738, 0021-9738 KW - Antibodies KW - 0 KW - Chemokine CXCL1 KW - Chemokine CXCL2 KW - Chemokines KW - Chemokines, CXC KW - Cxcl1 protein, mouse KW - Cxcl2 protein, mouse KW - IL8 protein, human KW - Interleukin-8 KW - Protein Kinase Inhibitors KW - Tumor Necrosis Factor-alpha KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Abridged Index Medicus KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Neutrophil Infiltration -- drug effects KW - Humans KW - Keratinocytes -- drug effects KW - Epidermis -- metabolism KW - Aged KW - Mice, Transgenic KW - Mice, Knockout KW - Epidermis -- drug effects KW - Antibodies -- pharmacology KW - Adult KW - Keratinocytes -- metabolism KW - Male KW - Chemokines -- blood KW - Protein Kinase Inhibitors -- pharmacology KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Chemokines -- immunology KW - Neutrophil Infiltration -- physiology KW - Mice KW - Gene Expression -- genetics KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Interleukin-8 -- genetics KW - Epidermis -- pathology KW - Middle Aged KW - Female KW - Dermatitis -- pathology KW - Chemokines, CXC -- metabolism KW - Protein Kinase C-alpha -- metabolism KW - Protein Kinase C-alpha -- antagonists & inhibitors KW - Granulocyte Colony-Stimulating Factor -- metabolism KW - Protein Kinase C-alpha -- genetics KW - Granulocyte Colony-Stimulating Factor -- genetics KW - Chemokines, CXC -- immunology KW - Dermatitis -- metabolism KW - Chemokines, CXC -- genetics KW - Granulocyte Colony-Stimulating Factor -- immunology KW - Chemokines, CXC -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68919258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Software+Engineering+and+Applications&rft.atitle=Proposing+a+Systematic+Approach+to+Verify+Software+Requirements&rft.au=Al-Khanjari%2C+Zuhoor+Abdullah+Salim&rft.aulast=Al-Khanjari&rft.aufirst=Zuhoor+Abdullah&rft.date=2014-04-01&rft.volume=7&rft.issue=4&rft.spage=218&rft.isbn=&rft.btitle=&rft.title=Journal+of+Software+Engineering+and+Applications&rft.issn=&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Res. 2000 Feb 1;60(3):595-602 [10676642] J Clin Invest. 2004 Jun;113(12):1664-75 [15199399] Immunity. 2000 Feb;12(2):121-7 [10714678] J Invest Dermatol. 2000 May;114(5):976-83 [10771480] Blood. 2000 May 15;95(10):3032-43 [10807766] Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12283-8 [11050248] Shock. 2001 Apr;15(4):278-84 [11303726] J Allergy Clin Immunol. 2001 May;107(5):871-7 [11344355] Int J Cancer. 2001 Sep 1;93(5):635-43 [11477572] Eur J Pharmacol. 2001 Sep 21;427(3):277-83 [11567658] J Immunol. 2001 Dec 15;167(12):7102-10 [11739532] Methods. 2001 Dec;25(4):402-8 [11846609] Pharmacol Rev. 2002 Jun;54(2):227-9 [12037138] Oncogene. 2002 Jul 18;21(31):4728-38 [12101411] Curr Opin Allergy Clin Immunol. 2002 Aug;2(4):325-31 [12130947] Am J Pathol. 2002 Oct;161(4):1409-18 [12368213] Immunity. 2002 Oct;17(4):413-23 [12387736] J Invest Dermatol. 2002 Dec;119(6):1282-9 [12485429] Exp Eye Res. 2003 Feb;76(2):221-31 [12565810] J Biol Chem. 2003 Mar 14;278(11):9944-52 [12645577] Cancer Res. 1999 Nov 15;59(22):5710-8 [10582689] Blood. 2004 Jul 15;104(2):565-71 [15054039] J Invest Dermatol. 1982 Mar;78(3):206-9 [6276474] Am J Pathol. 1986 May;123(2):241-9 [3518475] Acta Derm Venereol. 1990;70(1):57-9 [1967875] J Invest Dermatol. 1990 Oct;95(4):428-35 [2170539] J Invest Dermatol. 1991 Jul;97(1):73-9 [1711550] J Immunol. 1992 Feb 15;148(4):1119-28 [1310708] J Invest Dermatol. 1992 Sep;99(3):294-8 [1512465] Cell Growth Differ. 1992 Apr;3(4):233-9 [1515369] J Immunol. 1993 Oct 15;151(8):4399-406 [7691948] Am J Pathol. 1994 Apr;144(4):820-8 [7512793] Science. 1994 Jul 29;265(5172):682-4 [8036519] Blood. 1994 Sep 15;84(6):1737-46 [7521686] J Biol Chem. 1994 Nov 25;269(47):29355-8 [7961909] J Exp Med. 1994 Dec 1;180(6):2039-48 [7964481] J Immunol. 1995 Jun 1;154(11):6048-57 [7751647] J Immunol. 1995 Aug 15;155(4):2158-64 [7636264] Science. 1995 Sep 15;269(5230):1590-1 [7667641] J Invest Dermatol. 1996 Mar;106(3):526-30 [8648188] J Invest Dermatol. 1996 Nov;107(5):778-82 [8875965] J Exp Med. 1996 Nov 1;184(5):1825-32 [8920870] Immunity. 1996 Nov;5(5):491-501 [8934575] J Clin Invest. 1997 Jun 15;99(12):3009-17 [9185525] J Immunol. 1997 Oct 1;159(7):3595-602 [9317159] J Invest Dermatol. 1998 Jan;110(1):90-4 [9424095] N Engl J Med. 1998 Feb 12;338(7):436-45 [9459648] Blood. 1998 Aug 1;92(3):1062-9 [9680376] J Clin Invest. 1999 Mar;103(6):825-32 [10079103] Mol Cell Biol. 1999 Aug;19(8):5785-99 [10409765] J Cell Sci. 1999 Oct;112 ( Pt 20):3497-506 [10504298] Am J Pathol. 2005 Jan;166(1):117-26 [15632005] J Immunol. 2005 Feb 1;174(3):1686-92 [15661932] J Clin Invest. 2005 May;115(5):1150-62 [15864347] Nat Med. 2005 Jun;11(6):661-5 [15880119] Eur J Immunol. 2005 Sep;35(9):2573-82 [16094689] J Invest Dermatol. 2005 Oct;125(4):615-28 [16185259] J Immunol. 2003 May 1;170(9):4767-75 [12707358] J Immunol. 2003 Sep 1;171(5):2703-13 [12928424] Immunity. 2003 Oct;19(4):583-93 [14563322] Nat Rev Immunol. 2004 Mar;4(3):211-22 [15039758] Am J Physiol Gastrointest Liver Physiol. 2004 Jun;286(6):G1024-31 [14739142] Pharmacol Rev. 2000 Mar;52(1):145-76 [10699158] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. AN - 68917142; 16959481 AB - Deficiency in the long-chain omega-3 fatty acid, docosahexaenoic acid (DHA) has been associated with increased corticotropin releasing hormone and may contribute to hypothalamic pituitary axis (HPA) hyperactivity. Elevated levels of the neuroactive steroids, allopregnanolone (3alpha,5alpha-THP) and 3alpha,5alpha-tetrahydrodeoxycorticosterone (THDOC) appear to counter-regulate HPA hyperactivity. Plasma essential fatty acids and neurosteroids were assessed among 18 male healthy controls and among 34 male psychiatric patients with DSM-III alcoholism, depression, or both. Among all subjects, lower plasma DHA was correlated with higher plasma THDOC (r = -0.3, P < 0.05) and dihydroprogesterone (DHP) (r = -0.52, P < 0.05). Among psychiatric patients lower DHA was correlated with higher DHP (r = -0.60, P < 0.01), and among healthy controls lower plasma DHA was correlated with higher THDOC (r = -0.83, P < 0.01) and higher isopregnanolone (3beta,5alpha-THP) (r = -0.55, P < 0.05). In this pilot observational study, lower long-chain omega-3 essential fatty acid status was associated with higher neuroactive steroid concentrations, possibly indicating increased feedback inhibition of the HPA axis. JF - Prostaglandins, leukotrienes, and essential fatty acids AU - Nieminen, L R G AU - Makino, K K AU - Mehta, N AU - Virkkunen, M AU - Kim, H Y AU - Hibbeln, J R AD - National Institutes of Health, National Institutes on Alcoholism and Alcohol Abuse, Laboratory of Membrane Biophysics and Biochemistry, Bethesda, MD 20814, USA. PY - 2006 SP - 309 EP - 314 VL - 75 IS - 4-5 SN - 0952-3278, 0952-3278 KW - Fatty Acids, Omega-3 KW - 0 KW - Lipids KW - Psychotropic Drugs KW - Steroids KW - Docosahexaenoic Acids KW - 25167-62-8 KW - Desoxycorticosterone KW - 40GP35YQ49 KW - tetrahydrodeoxycorticosterone KW - 4AB717DP4A KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Pregnanolone KW - BXO86P3XXW KW - Index Medicus KW - Lipids -- blood KW - Pregnanolone -- blood KW - Humans KW - Pituitary-Adrenal System -- physiology KW - Desoxycorticosterone -- blood KW - Desoxycorticosterone -- analogs & derivatives KW - Hypothalamo-Hypophyseal System -- physiology KW - Mental Disorders -- blood KW - Pituitary-Adrenal System -- chemistry KW - Docosahexaenoic Acids -- analysis KW - Case-Control Studies KW - Hypothalamo-Hypophyseal System -- chemistry KW - Corticotropin-Releasing Hormone -- analysis KW - Female KW - Male KW - Fatty Acids, Omega-3 -- physiology KW - Steroids -- blood KW - Depression -- blood KW - Psychotropic Drugs -- blood KW - Alcoholism -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68917142?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.atitle=Relationship+between+omega-3+fatty+acids+and+plasma+neuroactive+steroids+in+alcoholism%2C+depression+and+controls.&rft.au=Nieminen%2C+L+R+G%3BMakino%2C+K+K%3BMehta%2C+N%3BVirkkunen%2C+M%3BKim%2C+H+Y%3BHibbeln%2C+J+R&rft.aulast=Nieminen&rft.aufirst=L+R&rft.date=2006-10-01&rft.volume=75&rft.issue=4-5&rft.spage=309&rft.isbn=&rft.btitle=&rft.title=Prostaglandins%2C+leukotrienes%2C+and+essential+fatty+acids&rft.issn=09523278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Oncogene-specific gene expression signatures at preneoplastic stage in mice define distinct mechanisms of hepatocarcinogenesis. AN - 68911293; 17006931 AB - We applied a genome-wide microarray analysis to three transgenic mouse models of liver cancer in which targeted overexpression of c-Myc, E2f1, and a combination of the two was driven by the albumin promoter. Although gene expression profiles in HCC derived in all three transgenic lines were highly similar, oncogene-specific gene expression signatures were identified at an early dysplastic stage of hepatocarcinogenesis. Overexpression of E2f1 was associated with a strong alteration in lipid metabolism, and Srebp1 was identified as a candidate transcription factor responsible for lipogenic enzyme induction. The molecular signature of c-Myc overexpression included the induction of more than 60 genes involved in the translational machinery that correlated with an increase in liver mass. In contrast, the combined activity of c-Myc and E2f1 specifically enhanced the expression of genes involved in mitochondrial metabolism--particularly the components of the respiratory chain--and correlated with an increased ATP synthesis. Thus, the results suggest that E2f1, c-Myc, and their combination may promote liver tumor development by distinct mechanisms. In conclusion, determination of tissue-specific oncogene expression signatures might be useful to identify conserved expression modules in human cancers. JF - Hepatology (Baltimore, Md.) AU - Coulouarn, Cédric AU - Gomez-Quiroz, Luis E AU - Lee, Ju-Seog AU - Kaposi-Novak, Pal AU - Conner, Elizabeth A AU - Goldina, Tatyana A AU - Onishchenko, Galina E AU - Factor, Valentina M AU - Thorgeirsson, Snorri S AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1003 EP - 1011 VL - 44 IS - 4 SN - 0270-9139, 0270-9139 KW - E2F1 Transcription Factor KW - 0 KW - E2f1 protein, mouse KW - Proto-Oncogene Proteins c-myc KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - Index Medicus KW - Protein Biosynthesis KW - Animals KW - DNA Repair KW - Oligonucleotide Array Sequence Analysis KW - Mitochondria, Liver -- metabolism KW - Adenosine Triphosphate -- metabolism KW - Disease Models, Animal KW - Mice KW - Lipid Metabolism -- genetics KW - Up-Regulation KW - Mice, Transgenic KW - Cell Cycle -- genetics KW - Proto-Oncogene Proteins c-myc -- biosynthesis KW - Gene Expression Regulation, Neoplastic KW - Liver Neoplasms -- metabolism KW - Carcinoma, Hepatocellular -- metabolism KW - Carcinoma, Hepatocellular -- genetics KW - Proto-Oncogene Proteins c-myc -- genetics KW - E2F1 Transcription Factor -- genetics KW - E2F1 Transcription Factor -- biosynthesis KW - Liver Neoplasms -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68911293?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.atitle=Oncogene-specific+gene+expression+signatures+at+preneoplastic+stage+in+mice+define+distinct+mechanisms+of+hepatocarcinogenesis.&rft.au=Coulouarn%2C+C%C3%A9dric%3BGomez-Quiroz%2C+Luis+E%3BLee%2C+Ju-Seog%3BKaposi-Novak%2C+Pal%3BConner%2C+Elizabeth+A%3BGoldina%2C+Tatyana+A%3BOnishchenko%2C+Galina+E%3BFactor%2C+Valentina+M%3BThorgeirsson%2C+Snorri+S&rft.aulast=Coulouarn&rft.aufirst=C%C3%A9dric&rft.date=2006-10-01&rft.volume=44&rft.issue=4&rft.spage=1003&rft.isbn=&rft.btitle=&rft.title=Hepatology+%28Baltimore%2C+Md.%29&rft.issn=02709139&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-03 N1 - Date created - 2006-10-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Medication-induced weight gain and dyslipidemia in patients with schizophrenia. AN - 68909828; 17012676 JF - The American journal of psychiatry AU - Fenton, Wayne S AU - Chavez, Mark R AD - Division of Adult Trasnlation Reserach and Treatment Development, NIMH, Bethesda, MD, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1697 EP - 704; quiz 1858-9 VL - 163 IS - 10 SN - 0002-953X, 0002-953X KW - Antipsychotic Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Metabolic Syndrome X -- chemically induced KW - Humans KW - Metabolic Syndrome X -- epidemiology KW - Metabolic Syndrome X -- diagnosis KW - Obesity -- chemically induced KW - Male KW - Comorbidity KW - Obesity -- blood KW - Weight Gain -- drug effects KW - Schizophrenia -- blood KW - Dyslipidemias -- blood KW - Antipsychotic Agents -- therapeutic use KW - Schizophrenia -- drug therapy KW - Schizophrenia -- epidemiology KW - Antipsychotic Agents -- adverse effects KW - Dyslipidemias -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68909828?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+of+psychiatry&rft.atitle=Medication-induced+weight+gain+and+dyslipidemia+in+patients+with+schizophrenia.&rft.au=Fenton%2C+Wayne+S%3BChavez%2C+Mark+R&rft.aulast=Fenton&rft.aufirst=Wayne&rft.date=2006-10-01&rft.volume=163&rft.issue=10&rft.spage=1697&rft.isbn=&rft.btitle=&rft.title=The+American+journal+of+psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-06 N1 - Date created - 2006-10-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiers. AN - 68908608; 17007558 AB - Radiation exposure at a young age is a strong risk factor for thyroid cancer. We conducted a nested case-control study of 69 thyroid cancer cases and 265 controls from a cohort of 14,054 childhood cancer survivors to evaluate the shape of the radiation dose-response relationship, in particular at high doses, and to assess modification of the radiation effects by patient and treatment characteristics. We considered several types of statistical models to estimate the excess relative risk (ERR), mainly guided by radiobiological models. A two-parameter model with a term linear in dose and a negative exponential in dose squared provided the best parsimonious description with an ERR of 1.3 per gray (95% confidence interval 0.4-4.1) at doses below 6 Gy and a relative decrease in ERR of 0.2% per unit dose squared with increasing dose, that is, decreases in the ERR/Gy of 53% at 20 Gy and 95% at 40 Gy. Further analyses using spline models suggested that the significant nonlinearity at high doses was characterized most appropriately as a true downturn rather than a flattening of the dose-response curve. We found no statistically significant modification of the dose-response relationship by patient characteristics; however, the linear parameter (i.e., the ERR/ Gy at doses less than 6 Gy) did decrease consistently and linearly with increasing age at childhood cancer diagnosis, from 4.45 for 0-1-year-olds to 0.48 for 15-20-year-olds. In summary, we applied models derived from radiobiology to describe the radiation dose-response curve for thyroid cancer in an epidemiological study and found convincing evidence for a downturn in risk at high doses. JF - Radiation research AU - Ronckers, Cécile M AU - Sigurdson, Alice J AU - Stovall, Marilyn AU - Smith, Susan A AU - Mertens, Ann C AU - Liu, Yan AU - Hammond, Sue AU - Land, Charles E AU - Neglia, Joseph P AU - Donaldson, Sarah S AU - Meadows, Anna T AU - Sklar, Charles A AU - Robison, Leslie L AU - Inskip, Peter D AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland. c.m.ronckers@amc.uva.nl Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 618 EP - 628 VL - 166 IS - 4 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Disease-Free Survival KW - Neoplasms -- radiotherapy KW - Risk Factors KW - Radiotherapy Dosage KW - Humans KW - Neoplasms -- epidemiology KW - Incidence KW - Child KW - Dose-Response Relationship, Radiation KW - United States -- epidemiology KW - Male KW - Female KW - Thyroid Neoplasms -- epidemiology KW - Survivors -- statistics & numerical data KW - Risk Assessment -- methods KW - Radiotherapy -- statistics & numerical data KW - Proportional Hazards Models UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68908608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Thyroid+cancer+in+childhood+cancer+survivors%3A+a+detailed+evaluation+of+radiation+dose+response+and+its+modifiers.&rft.au=Ronckers%2C+C%C3%A9cile+M%3BSigurdson%2C+Alice+J%3BStovall%2C+Marilyn%3BSmith%2C+Susan+A%3BMertens%2C+Ann+C%3BLiu%2C+Yan%3BHammond%2C+Sue%3BLand%2C+Charles+E%3BNeglia%2C+Joseph+P%3BDonaldson%2C+Sarah+S%3BMeadows%2C+Anna+T%3BSklar%2C+Charles+A%3BRobison%2C+Leslie+L%3BInskip%2C+Peter+D&rft.aulast=Ronckers&rft.aufirst=C%C3%A9cile&rft.date=2006-10-01&rft.volume=166&rft.issue=4&rft.spage=618&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The selective dopamine D3 receptor antagonist SB-277011A reduces nicotine-enhanced brain reward and nicotine-paired environmental cue functions. AN - 68903018; 16942635 AB - Increasing evidence suggests that enhanced dopamine (DA) neurotransmission in the nucleus accumbens (NAc) may play a role in mediating the reward and reinforcement produced by addictive drugs and in the attentional processing of drug-associated environmental cues. The meso-accumbens DA system is selectively enriched with DA D3 receptors, a DA receptor subtype increasingly implicated in reward-related brain and behavioural processes. From a variety of evidence, it has been suggested that selective DA D3 receptor antagonism may be a useful pharmacotherapeutic approach for treating addiction. The present experiments tested the efficacy of SB-277011A, a selective DA D3 receptor antagonist, in rat models of nicotine-enhanced electrical brain-stimulation reward (BSR), nicotine-induced conditioned locomotor activity (LMA), and nicotine-induced conditioned place preference (CPP). Nicotine was given subcutaneously within the dose range of 0.25-0.6 mg/kg (nicotine-free base). SB-277011A, given intraperitoneally within the dose range of 1-12 mg/kg, dose-dependently reduced nicotine-enhanced BSR, nicotine-induced conditioned LMA, and nicotine-induced CPP. The results suggest that selective D3 receptor antagonism constitutes a new and promising pharmacotherapeutic approach to the treatment of nicotine dependence. JF - The international journal of neuropsychopharmacology AU - Pak, Arlene C AU - Ashby, Charles R AU - Heidbreder, Christian A AU - Pilla, Maria AU - Gilbert, Jeremy AU - Xi, Zheng-Xiong AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 585 EP - 602 VL - 9 IS - 5 SN - 1461-1457, 1461-1457 KW - Dopamine Antagonists KW - 0 KW - Nicotinic Agonists KW - Nitriles KW - SB 277011 KW - Tetrahydroisoquinolines KW - Nicotine KW - 6M3C89ZY6R KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Drug Interactions KW - Analysis of Variance KW - Rats, Long-Evans KW - Area Under Curve KW - Dose-Response Relationship, Drug KW - Association Learning -- drug effects KW - Cues KW - Motor Activity -- drug effects KW - Male KW - Conditioning, Operant -- drug effects KW - Nitriles -- pharmacology KW - Reward KW - Nicotine -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Brain -- drug effects KW - Tetrahydroisoquinolines -- pharmacology KW - Nicotinic Agonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68903018?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+international+journal+of+neuropsychopharmacology&rft.atitle=The+selective+dopamine+D3+receptor+antagonist+SB-277011A+reduces+nicotine-enhanced+brain+reward+and+nicotine-paired+environmental+cue+functions.&rft.au=Pak%2C+Arlene+C%3BAshby%2C+Charles+R%3BHeidbreder%2C+Christian+A%3BPilla%2C+Maria%3BGilbert%2C+Jeremy%3BXi%2C+Zheng-Xiong%3BGardner%2C+Eliot+L&rft.aulast=Pak&rft.aufirst=Arlene&rft.date=2006-10-01&rft.volume=9&rft.issue=5&rft.spage=585&rft.isbn=&rft.btitle=&rft.title=The+international+journal+of+neuropsychopharmacology&rft.issn=14611457&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Drugs Today (Barc). 2004 Apr;40(4):355-65 [15190388] Neuropharmacology. 2004;47 Suppl 1:190-201 [15464137] Psychopharmacology (Berl). 2004 Oct;176(1):57-65 [15083257] Science. 1975 Feb 14;187(4176):547-9 [1114313] Psychopharmacology (Berl). 1976 Aug 17;48(3):311-8 [823588] Can J Psychol. 1977 Dec;31(4):195-203 [608135] Psychopharmacology (Berl). 1982;78(3):204-9 [6296898] Physiol Behav. 1985 Sep;35(3):395-403 [3840902] Eur J Pharmacol. 1986 Dec 16;132(2-3):337-8 [3816984] Behav Neurosci. 1987 Apr;101(2):209-14 [3580122] Eur J Pharmacol. 1987 Sep 23;141(3):395-9 [3666033] Behav Brain Res. 1987 Oct;26(1):57-62 [3675835] Psychiatr Med. 1985;3(4):445-60 [2893431] Eur J Pharmacol. 1988 Jul 7;151(2):233-42 [2844553] Annu Rev Psychol. 1989;40:191-225 [2648975] Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb;339(1-2):208-13 [2725697] Br J Pharmacol. 1989 Sep;98(1):135-40 [2804543] Neurosci Biobehav Rev. 1989 Summer-Fall;13(2-3):123-8 [2530477] Ciba Found Symp. 1990;152:153-62; 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AN - 68898821; 16488893 AB - Studies of latent traits often collect data for multiple items measuring different aspects of the trait. For such data, it is common to consider models in which the different items are manifestations of a normal latent variable, which depends on covariates through a linear regression model. This article proposes a flexible Bayesian alternative in which the unknown latent variable density can change dynamically in location and shape across levels of a predictor. Scale mixtures of underlying normals are used in order to model flexibly the measurement errors and allow mixed categorical and continuous scales. A dynamic mixture of Dirichlet processes is used to characterize the latent response distributions. Posterior computation proceeds via a Markov chain Monte Carlo algorithm, with predictive densities used as a basis for inferences and evaluation of model fit. The methods are illustrated using data from a study of DNA damage in response to oxidative stress. JF - Biostatistics (Oxford, England) AU - Dunson, David B AD - Biostatistics Branch, National Institute of Environmental Health Sciences, MD A3-03, Research Triangle Park, NC 27709, USA. dunson1@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 551 EP - 568 VL - 7 IS - 4 SN - 1465-4644, 1465-4644 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Index Medicus KW - Hydrogen Peroxide -- toxicity KW - Biometry -- methods KW - DNA Damage KW - Humans KW - Oxidative Stress KW - Algorithms KW - Models, Statistical KW - Markov Chains KW - Monte Carlo Method KW - Statistics, Nonparametric KW - Cell Line KW - Bayes Theorem KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68898821?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biostatistics+%28Oxford%2C+England%29&rft.atitle=Bayesian+dynamic+modeling+of+latent+trait+distributions.&rft.au=Dunson%2C+David+B&rft.aulast=Dunson&rft.aufirst=David&rft.date=2006-10-01&rft.volume=7&rft.issue=4&rft.spage=551&rft.isbn=&rft.btitle=&rft.title=Biostatistics+%28Oxford%2C+England%29&rft.issn=14654644&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. AN - 68898623; 16728435 AB - Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double-strand breaks (DSB) are one of the most severe DNA lesions caused directly and indirectly by benzene metabolites. DSB may lead to chromosome aberrations, apoptosis and hematopoietic progenitor cell suppression. We hypothesized that genetic polymorphisms in genes involved in DNA DSB repair may modify benzene-induced hematotoxicity. We analyzed one or more single nucleotide polymorphisms (SNPs) in each of seven candidate genes (WRN, TP53, NBS1, BRCA1, BRCA2, XRCC3 and XRCC4) in a study of 250 workers exposed to benzene and 140 controls in China. Four SNPs in WRN (Ex4 -16 G > A, Ex6 +9 C > T, Ex20 -88 G > T and Ex26 -12 T > G), one SNP in TP53 (Ex4 +119 C > G) and one SNP in BRCA2 (Ex11 +1487 A > G) were associated with a statistically significant decrease in total white blood cell (WBC) counts among exposed workers. The SNPs in WRN and TP53 remained significant after accounting for multiple comparisons. One or more SNPs in WRN had broad effects on WBC subtypes, with significantly decreased granulocyte, total lymphocyte, CD4(+)-T cell, CD8(+)-T cell and monocyte counts. Haplotypes of WRN were associated with decreased WBC counts among benzene-exposed subjects. Likewise, subjects with TP53 Ex4 +119 C > G variant had reduced granulocyte, CD4(+)-T cell and B cell counts. The effect of BRCA2 Ex11 +1487 A > G polymorphism was limited to granulocytes. These results suggest that genetic polymorphisms in WRN, TP53 and BRCA2 that maintain genomic stability impact benzene-induced hematotoxicity. JF - Carcinogenesis AU - Shen, Min AU - Lan, Qing AU - Zhang, Luoping AU - Chanock, Stephen AU - Li, Guilan AU - Vermeulen, Roel AU - Rappaport, Stephen M AU - Guo, Weihong AU - Hayes, Richard B AU - Linet, Martha AU - Yin, Songnian AU - Yeager, Meredith AU - Welch, Robert AU - Forrest, Matthew S AU - Rothman, Nathaniel AU - Smith, Martyn T AD - Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD 20892, USA. shenmi@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2083 EP - 2089 VL - 27 IS - 10 SN - 0143-3334, 0143-3334 KW - Exodeoxyribonucleases KW - EC 3.1.- KW - DNA Helicases KW - EC 3.6.4.- KW - RecQ Helicases KW - EC 3.6.4.12 KW - WRN protein, human KW - Werner Syndrome Helicase KW - Benzene KW - J64922108F KW - Index Medicus KW - Cross-Sectional Studies KW - Haplotypes KW - Genes, p53 KW - Humans KW - Adult KW - Genes, BRCA2 KW - DNA Helicases -- genetics KW - Male KW - Female KW - DNA Repair -- genetics KW - Polymorphism, Single Nucleotide KW - Benzene -- toxicity KW - Genetic Predisposition to Disease KW - Blood Cells -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68898623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+genes+involved+in+DNA+double-strand+break+repair+pathway+and+susceptibility+to+benzene-induced+hematotoxicity.&rft.au=Shen%2C+Min%3BLan%2C+Qing%3BZhang%2C+Luoping%3BChanock%2C+Stephen%3BLi%2C+Guilan%3BVermeulen%2C+Roel%3BRappaport%2C+Stephen+M%3BGuo%2C+Weihong%3BHayes%2C+Richard+B%3BLinet%2C+Martha%3BYin%2C+Songnian%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BForrest%2C+Matthew+S%3BRothman%2C+Nathaniel%3BSmith%2C+Martyn+T&rft.aulast=Shen&rft.aufirst=Min&rft.date=2006-10-01&rft.volume=27&rft.issue=10&rft.spage=2083&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Purification, crystallization and preliminary X-ray diffraction analysis of the phage T4 vertex protein gp24 and its mutant forms. AN - 68896178; 16884923 AB - The study of bacteriophage T4 assembly has revealed regulatory mechanisms pertinent not only to viruses but also to macromolecular complexes. The capsid of bacteriophage T4 is composed of the major capsid protein gp23, and a minor capsid protein gp24, which is arranged as pentamers at the vertices of the capsid. In this study the T4 capsid protein gp24 and its mutant forms were overexpressed and purified to homogeneity. The overexpression from plasmid vectors of all the constructs in Escherichia coli yields biologically active protein in vivo as determined by assembly of active virus following infection with inactivated gene 24 mutant viruses. The gp24 mutant was subjected to surface entropy reduction by mutagenesis and reductive alkylation in order to improve its crystallization properties and diffraction quality. To determine if surface mutagenesis targeting would result in diffractable crystals, two glutamate to alanine mutations (E89A,E90A) were introduced. We report here the biochemical observations and consequent mutagenesis experiment that resulted in improvements in the stability, crystallizability and crystal quality of gp24 without affecting the overall folding. Rational modification of the protein surface to achieve crystallization appears promising for improving crystallization behavior and crystal diffracting qualities. The crystal of gp24(E89A,E90A) diffracted to 2.6A resolution compared to wild-type gp24 at 3.80A resolution under the same experimental conditions. Surface mutation proved to be a better method than reductive methylation for improving diffraction quality of the gp24 crystals. JF - Protein expression and purification AU - Boeshans, Karen M AU - Liu, Fang AU - Peng, Guihong AU - Idler, William AU - Jang, Shyh-Ing AU - Marekov, Lyuben AU - Black, Lindsay AU - Ahvazi, Bijan AD - X-ray Crystallography Facility/Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8024, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 235 EP - 243 VL - 49 IS - 2 SN - 1046-5928, 1046-5928 KW - Capsid Proteins KW - 0 KW - gene 24 protein, Enterobacteria phage T4 KW - Index Medicus KW - Virus Assembly -- physiology KW - Protein Structure, Tertiary KW - Crystallography, X-Ray -- methods KW - Capsid Proteins -- isolation & purification KW - Escherichia coli -- genetics KW - Mutation, Missense KW - Capsid Proteins -- genetics KW - Capsid Proteins -- chemistry KW - Amino Acid Substitution KW - Capsid Proteins -- biosynthesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68896178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+expression+and+purification&rft.atitle=Purification%2C+crystallization+and+preliminary+X-ray+diffraction+analysis+of+the+phage+T4+vertex+protein+gp24+and+its+mutant+forms.&rft.au=Boeshans%2C+Karen+M%3BLiu%2C+Fang%3BPeng%2C+Guihong%3BIdler%2C+William%3BJang%2C+Shyh-Ing%3BMarekov%2C+Lyuben%3BBlack%2C+Lindsay%3BAhvazi%2C+Bijan&rft.aulast=Boeshans&rft.aufirst=Karen&rft.date=2006-10-01&rft.volume=49&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Protein+expression+and+purification&rft.issn=10465928&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Postnatal inflammatory rat model for cerebral palsy: too different from humans. AN - 68890233; 17000237 AB - In humans, cerebral palsy (CP) may originate from inflammation during the second and third trimesters of gestation when preoligodendrocytes (Pre-OL) are most vulnerable to an inflammatory insult. We studied a postnatal CP model to evaluate injury that would correlate with presence of Pre-OL in human pregnancy. On postnatal (P) days 2, 3, 4, 5 and 6, pups were treated with (lipopolysaccharide [LPS]) (n = 7; 30, 30, 60, 60, 120 microg/Kg) or saline (n = 7). Neonates were tested for motor and cognitive development. Adult offspring performed beam walking and rotarod for motor activity. White matter damage was assessed with immunohistochemical Pre-OL markers (CNP, PLP). Statistical analysis included Mann-Whitney U and analysis of variance. LPS-treated animals performed negative geotaxis (P = .009) and surface righting (P = .01) earlier than controls. No differences were observed for other neonatal tests. Adult LPS-treated offspring performed better in tests of motor control: rotarod (P = .01) and beam walking (P = .02). Pre-OL markers were altered in LPS-treated animals at both P22 (CNP and PLP increased in LPS, P < .01 and P < .001, respectively) and 12 weeks (CNP and PLP decreased in LPS, P < .0001 and P < .03, respectively). Neonatal exposure to LPS induced white matter damage in the brain, accelerated neurodevelopment and motor tasks in adulthood. These are similar to findings from a postnatal hypoxic model suggesting that in the rodent, targeting the Pre-OL does not result in a CP phenotype. JF - American journal of obstetrics and gynecology AU - Roberson, Robin AU - Woodard, Jade E AU - Toso, Laura AU - Abebe, Daniel AU - Poggi, Sarah H AU - Spong, Catherine Y AD - Unit on Perinatal and Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1038 EP - 1044 VL - 195 IS - 4 KW - Lipopolysaccharides KW - 0 KW - Myelin Proteolipid Protein KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases KW - EC 3.1.4.- KW - Abridged Index Medicus KW - Index Medicus KW - Myelin Proteolipid Protein -- analysis KW - Animals KW - 2',3'-Cyclic-Nucleotide Phosphodiesterases -- analysis KW - Humans KW - Behavior, Animal KW - Pregnancy KW - Rats KW - Animals, Newborn KW - Rats, Inbred F344 KW - Lipopolysaccharides -- toxicity KW - Species Specificity KW - Immunohistochemistry KW - Female KW - Disease Models, Animal KW - Inflammation -- complications KW - Cerebral Palsy -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68890233?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Postnatal+inflammatory+rat+model+for+cerebral+palsy%3A+too+different+from+humans.&rft.au=Roberson%2C+Robin%3BWoodard%2C+Jade+E%3BToso%2C+Laura%3BAbebe%2C+Daniel%3BPoggi%2C+Sarah+H%3BSpong%2C+Catherine+Y&rft.aulast=Roberson&rft.aufirst=Robin&rft.date=2006-10-01&rft.volume=195&rft.issue=4&rft.spage=1038&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha. AN - 68887125; 16807375 AB - Nicotinamide adenine dinucleotide (NAD) plays a critical role in the maintenance of cellular energy homeostasis. alpha-Amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is the key enzyme regulating de novo synthesis of NAD from l-tryptophan (Trp), designated the Trp-NAD pathway. Acmsd gene expression was found to be under the control of both hepatocyte nuclear factor 4alpha (HNF4alpha) and peroxisome proliferator-activated receptor alpha (PPARalpha). Constitutive expression of ACMSD mRNA levels were governed by HNF4alpha and downregulated by activation of PPARalpha by the ligand Wy-14,643 ([4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio]acetic acid]), as revealed by studies with hepatic HNF4alpha-null mice and PPARalpha-null mice, respectively. Transient transfection and electrophoretic mobility shift analyses showed an HNF4alpha binding site in the Acmsd gene promoter that directed transactivation of reporter gene constructs by HNF4alpha. The Acmsd promoter was not responsive to PPARalpha in transactivation assays. Wy-14,643 treatment decreased HNF4alpha protein levels in wild-type, but not PPARalpha-null, mouse livers, with no changes in HNF4alpha mRNA. These results show that Wy-14,643, through PPARalpha, post-transcriptionally down-regulates HNF4alpha protein levels, leading to reduced expression of the HNF4alpha target gene Acmsd. JF - Molecular pharmacology AU - Shin, Mariko AU - Kim, Insook AU - Inoue, Yusuke AU - Kimura, Shioko AU - Gonzalez, Frank J AD - Laboratory of Metabolism, Building 37, Room 3106, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1281 EP - 1290 VL - 70 IS - 4 SN - 0026-895X, 0026-895X KW - Hepatocyte Nuclear Factor 4 KW - 0 KW - PPAR alpha KW - Peroxisome Proliferators KW - Pyrimidines KW - NAD KW - 0U46U6E8UK KW - pirinixic acid KW - 86C4MRT55A KW - Tryptophan KW - 8DUH1N11BX KW - Carboxy-Lyases KW - EC 4.1.1.- KW - aminocarboxymuconate-semialdehyde decarboxylase KW - EC 4.1.1.45 KW - Index Medicus KW - Transcription Initiation Site KW - Animals KW - Humans KW - Peroxisome Proliferators -- pharmacology KW - Pyrimidines -- pharmacology KW - Mice KW - Tryptophan -- metabolism KW - Mice, Transgenic KW - Binding Sites KW - Base Sequence KW - Promoter Regions, Genetic KW - Transfection KW - Cercopithecus aethiops KW - Molecular Sequence Data KW - Signal Transduction KW - NAD -- metabolism KW - Liver -- enzymology KW - Gene Expression Regulation, Enzymologic KW - Hepatocyte Nuclear Factor 4 -- physiology KW - Hepatocyte Nuclear Factor 4 -- genetics KW - PPAR alpha -- physiology KW - Carboxy-Lyases -- genetics KW - Hepatocyte Nuclear Factor 4 -- metabolism KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68887125?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=Regulation+of+mouse+hepatic+alpha-amino-beta-carboxymuconate-epsilon-semialdehyde+decarboxylase%2C+a+key+enzyme+in+the+tryptophan-nicotinamide+adenine+dinucleotide+pathway%2C+by+hepatocyte+nuclear+factor+4alpha+and+peroxisome+proliferator-activated+receptor+alpha.&rft.au=Shin%2C+Mariko%3BKim%2C+Insook%3BInoue%2C+Yusuke%3BKimura%2C+Shioko%3BGonzalez%2C+Frank+J&rft.aulast=Shin&rft.aufirst=Mariko&rft.date=2006-10-01&rft.volume=70&rft.issue=4&rft.spage=1281&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-29 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxins in the treatment of refractory hairy cell leukemia. AN - 68886281; 16990113 AB - An increasing number of patients who have hairy cell leukemia (HCL) have persistent disease that requires treatment, despite purine analogs, splenectomy, interferon, and rituximab. Many of these patients have been treated successfully with immunotoxins. An immunotoxin contains a protein toxin connected to a cell-binding ligand, such as an antibody. An immunotoxin recognizes the target cell, internalizes, and the toxin translocates to the cytosol where it inhibits protein synthesis enzymatically. Immunotoxins that show activity in HCL contain truncated Psedomonas exotoxin fused to the Fv fragments of anti-CD25 or anti-CD22 monoclonal antibodies. Both agents, termed LMB-2 and BL22, respectively, have been tested in patients who have HCL after failure of purine analogs and other therapies; major responses have been achieved in most patients. JF - Hematology/oncology clinics of North America AU - Kreitman, Robert J AU - Pastan, Ira AD - Clinical Immunotherapy Section, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Building 37, Room 5124b, Bethesda, MD 20892-4255, USA. kreitmar@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1137 EP - 51, viii VL - 20 IS - 5 SN - 0889-8588, 0889-8588 KW - Antibodies, Monoclonal KW - 0 KW - B3(Fv)-PE38KDEL recombinant immunotoxin KW - Bacterial Toxins KW - Exotoxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Receptors, Interleukin-2 KW - Sialic Acid Binding Ig-like Lectin 2 KW - Virulence Factors KW - ADP Ribose Transferases KW - EC 2.4.2.- KW - toxA protein, Pseudomonas aeruginosa KW - EC 2.4.2.31 KW - Index Medicus KW - Disease-Free Survival KW - Sialic Acid Binding Ig-like Lectin 2 -- immunology KW - Clinical Trials as Topic KW - Remission Induction -- methods KW - Receptors, Interleukin-2 -- immunology KW - Leukemia, Hairy Cell -- mortality KW - ADP Ribose Transferases -- immunology KW - Virulence Factors -- therapeutic use KW - Immunoglobulin Variable Region -- immunology KW - Bacterial Toxins -- immunology KW - Exotoxins -- immunology KW - Virulence Factors -- immunology KW - Immunoglobulin Variable Region -- therapeutic use KW - ADP Ribose Transferases -- therapeutic use KW - Antibodies, Monoclonal -- immunology KW - Antibodies, Monoclonal -- therapeutic use KW - Bacterial Toxins -- therapeutic use KW - Leukemia, Hairy Cell -- drug therapy KW - Immunotoxins -- therapeutic use KW - Exotoxins -- therapeutic use KW - Leukemia, Hairy Cell -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68886281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Hematology%2Foncology+clinics+of+North+America&rft.atitle=Immunotoxins+in+the+treatment+of+refractory+hairy+cell+leukemia.&rft.au=Kreitman%2C+Robert+J%3BPastan%2C+Ira&rft.aulast=Kreitman&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=20&rft.issue=5&rft.spage=1137&rft.isbn=&rft.btitle=&rft.title=Hematology%2Foncology+clinics+of+North+America&rft.issn=08898588&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. AN - 68884883; 16837625 AB - The ATP-driven drug export pump, P-glycoprotein, is a primary gatekeeper of the blood-brain barrier and a major impediment to central nervous system (CNS) pharmacotherapy. Reducing P-glycoprotein activity dramatically increases penetration of many therapeutic drugs into the CNS. Previous studies in rat showed that brain capillary P-glycoprotein was transcriptionally up-regulated by the pregnane X receptor (PXR), a xenobiotic-activated nuclear receptor. Here we used a transgenic mouse expressing human PXR (hPXR) to determine the consequences of increased blood-brain barrier P-glycoprotein activity. P-glycoprotein expression and transport activity in brain capillaries from transgenic mice was significantly increased when capillaries were exposed to the hPXR ligands, rifampin and hyperforin, in vitro and when the mice were dosed with rifampin in vivo. Plasma rifampin levels in induced mice were comparable with literature values for patients. We also administered methadone, a CNS-acting, P-glycoprotein substrate, to control and rifampin-induced transgenic mice and measured the drug's antinociceptive effect. In rifampin-induced mice, the methadone effect was reduced by approximately 70%, even though plasma methadone levels were similar to those found in transgenic controls not exposed to rifampin. Thus, hPXR activation in vivo increased P-glycoprotein activity and tightened the blood-brain barrier to methadone, reducing the drug's CNS efficacy. This is the first demonstration of the ability of blood-brain barrier PXR to alter the efficacy of a CNS-acting drug. JF - Molecular pharmacology AU - Bauer, Björn AU - Yang, Xiaodong AU - Hartz, Anika M S AU - Olson, Emily R AU - Zhao, Rong AU - Kalvass, J Cory AU - Pollack, Gary M AU - Miller, David S AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 TW Alexander Drive, Research Triangle Park, NC 27709, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1212 EP - 1219 VL - 70 IS - 4 SN - 0026-895X, 0026-895X KW - Analgesics KW - 0 KW - P-Glycoprotein KW - P-Glycoproteins KW - Receptors, Steroid KW - multidrug resistance protein 3 KW - pregnane X receptor KW - Methadone KW - UC6VBE7V1Z KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Animals KW - Drug Interactions KW - Dose-Response Relationship, Drug KW - Brain -- blood supply KW - Humans KW - Rifampin -- pharmacokinetics KW - Analgesics -- pharmacology KW - Brain -- metabolism KW - Mice KW - Mice, Transgenic KW - P-Glycoproteins -- genetics KW - In Vitro Techniques KW - ATP-Binding Cassette Transporters -- genetics KW - Mice, Inbred C57BL KW - Rifampin -- pharmacology KW - Male KW - Receptors, Steroid -- physiology KW - P-Glycoprotein -- metabolism KW - Receptors, Steroid -- metabolism KW - Methadone -- pharmacokinetics KW - Up-Regulation KW - Receptors, Steroid -- genetics KW - Methadone -- metabolism KW - Methadone -- pharmacology KW - Blood-Brain Barrier UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68884883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+pharmacology&rft.atitle=In+vivo+activation+of+human+pregnane+X+receptor+tightens+the+blood-brain+barrier+to+methadone+through+P-glycoprotein+up-regulation.&rft.au=Bauer%2C+Bj%C3%B6rn%3BYang%2C+Xiaodong%3BHartz%2C+Anika+M+S%3BOlson%2C+Emily+R%3BZhao%2C+Rong%3BKalvass%2C+J+Cory%3BPollack%2C+Gary+M%3BMiller%2C+David+S&rft.aulast=Bauer&rft.aufirst=Bj%C3%B6rn&rft.date=2006-10-01&rft.volume=70&rft.issue=4&rft.spage=1212&rft.isbn=&rft.btitle=&rft.title=Molecular+pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-29 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peroxisome proliferator-activated receptor alpha activation during pregnancy severely impairs mammary lobuloalveolar development in mice. AN - 68875600; 16857745 AB - To identify the potential functions of peroxisome proliferator-activated receptor alpha (PPARalpha) in skin development, transgenic mice were generated to target constitutively activated PPARalpha (VP16PPARalpha) to the stratified epithelia by use of the keratin K5 promoter. In addition to marked alterations in epidermal development, the transgenic mice had a severe defect in lactation during pregnancy resulting in 100% pup mortality. In this study, the alteration of mammary gland development in these transgenic mice was investigated. The results showed that expression of the VP16PPARalpha transgene during pregnancy resulted in impaired development of lobuloalveoli, which is associated with reduced proliferation and increased apoptosis of mammary epithelia. Mammary epithelia from transgenic mice also showed a significant reduction in the expression of beta-catenin and a down-regulation of one of its target genes, cyclin D1, which is thought to be required for lobuloalveolar development. Furthermore, upon PPARalpha ligand treatment, similar effects on lobuloalveolar development were observed in wild-type mice, but not in PPARalpha-null mice. These findings suggest that PPARalpha activation has a marked influence in mammary lobuloalveolar development. JF - Endocrinology AU - Yang, Qian AU - Kurotani, Reiko AU - Yamada, Atsushi AU - Kimura, Shioko AU - Gonzalez, Frank J AD - Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 4772 EP - 4780 VL - 147 IS - 10 SN - 0013-7227, 0013-7227 KW - Caseins KW - 0 KW - Coloring Agents KW - Fluorescent Dyes KW - PPAR alpha KW - Pyrimidines KW - beta Catenin KW - Cyclin D1 KW - 136601-57-5 KW - pirinixic acid KW - 86C4MRT55A KW - Eosine Yellowish-(YS) KW - TDQ283MPCW KW - Hematoxylin KW - YKM8PY2Z55 KW - Abridged Index Medicus KW - Index Medicus KW - Promoter Regions, Genetic -- physiology KW - Lactation -- physiology KW - Animals KW - beta Catenin -- biosynthesis KW - Blotting, Northern KW - Apoptosis -- physiology KW - Survival KW - Pyrimidines -- pharmacology KW - Mice KW - Cyclin D1 -- biosynthesis KW - Reverse Transcriptase Polymerase Chain Reaction KW - Mice, Transgenic KW - Cell Proliferation KW - Animals, Newborn -- physiology KW - Caseins -- biosynthesis KW - Caseins -- genetics KW - Immunohistochemistry KW - Female KW - PPAR alpha -- drug effects KW - Mammary Glands, Animal -- physiology KW - Pregnancy -- physiology KW - Mammary Glands, Animal -- growth & development KW - PPAR alpha -- physiology KW - PPAR alpha -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68875600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrinology&rft.atitle=Peroxisome+proliferator-activated+receptor+alpha+activation+during+pregnancy+severely+impairs+mammary+lobuloalveolar+development+in+mice.&rft.au=Yang%2C+Qian%3BKurotani%2C+Reiko%3BYamada%2C+Atsushi%3BKimura%2C+Shioko%3BGonzalez%2C+Frank+J&rft.aulast=Yang&rft.aufirst=Qian&rft.date=2006-10-01&rft.volume=147&rft.issue=10&rft.spage=4772&rft.isbn=&rft.btitle=&rft.title=Endocrinology&rft.issn=00137227&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Endocrinol. 2005 May;19(5):1135-46 [15661831] Development. 2005 Jan;132(2):267-77 [15590737] J Biol Chem. 2005 Oct 28;280(43):36301-9 [16120603] Endocr Rev. 2005 Dec;26(7):898-915 [16126938] Vet Pathol. 2006 Jan;43(1):36-49 [16407485] Nat Rev Mol Cell Biol. 2005 Sep;6(9):715-25 [16231422] Proc Natl Acad Sci U S A. 1999 May 11;96(10):5522-7 [10318916] Nature. 1999 Apr 1;398(6726):422-6 [10201372] Biochem Biophys Res Commun. 1998 Dec 30;253(3):813-7 [9918810] J Invest Dermatol. 1998 Dec;111(6):1116-21 [9856826] Carcinogenesis. 1998 Nov;19(11):1989-94 [9855014] J Invest Dermatol. 1998 Sep;111(3):429-33 [9740236] Cell. 2000 Sep 29;103(1):41-50 [11051546] J Invest Dermatol. 2000 Nov;115(5):788-94 [11069615] J Biol Chem. 2000 Sep 1;275(35):27117-22 [10852923] Science. 2000 Aug 11;289(5481):950-3 [10937998] J Med Chem. 2000 Feb 24;43(4):527-50 [10691680] Cancer Res. 1999 Nov 15;59(22):5671-3 [10582681] J Invest Dermatol. 1999 Nov;113(5):788-95 [10571735] J Invest Dermatol. 2006 Feb;126(2):374-85 [16374467] Anticancer Res. 2001 Mar-Apr;21(2A):825-9 [11396171] Endocrinology. 2001 Oct;142(10):4195-202 [11564675] J Cell Biol. 2001 Dec 10;155(6):1055-64 [11739413] J Biol Chem. 2002 Feb 15;277(7):5339-44 [11726661] Int J Dev Biol. 2002 Jan;46(1):105-14 [11902671] Mol Endocrinol. 2002 May;16(5):1013-28 [11981036] Mol Endocrinol. 2002 May;16(5):1029-39 [11981037] Endocrinology. 2002 Nov;143(11):4358-65 [12399432] Dev Cell. 2002 Dec;3(6):877-87 [12479812] J Cell Sci. 2003 Mar 15;116(Pt 6):1137-49 [12584256] Breast Cancer Res Treat. 2003 Mar;78(2):179-92 [12725418] J Lipid Res. 2003 Jun;44(6):1100-12 [12700340] Oncogene. 2003 Aug 21;22(35):5415-26 [12934101] J Invest Dermatol. 2004 Apr;122(4):971-83 [15102088] Carcinogenesis. 2004 Sep;25(9):1747-55 [15073042] J Biol Chem. 2004 Oct 22;279(43):45020-7 [15308623] Nature. 1990 Oct 18;347(6294):645-50 [2129546] Nature. 1992 Jan 30;355(6359):446-9 [1310351] Cell. 1992 Mar 6;68(5):879-87 [1312391] Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5547-51 [1319065] Nature. 1992 Aug 27;358(6389):771-4 [1324435] Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2160-4 [8384714] Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7355-9 [8041794] Mol Cell Biol. 1995 Jun;15(6):3012-22 [7539101] Science. 1995 Jun 23;268(5218):1766-9 [7792603] Cell. 1995 Aug 25;82(4):621-30 [7664341] Genes Dev. 1995 Oct 1;9(19):2364-72 [7557388] Endocrinology. 1996 Jan;137(1):354-66 [8536636] Development. 1996 Dec;122(12):4013-22 [9012521] J Clin Invest. 1997 Aug 1;100(3):705-12 [9239419] J Biol Chem. 1997 Oct 24;272(43):27307-12 [9341179] J Invest Dermatol. 1998 Apr;110(4):368-75 [9540977] Genes Dev. 1998 Jun 15;12(12):1917-28 [9637692] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking. AN - 68868839; 16341024 AB - Using a rat relapse model, we previously reported that re-exposing rats to a drug-associated context, following extinction of operant responding in a different context, reinstates heroin seeking. In an initial pharmacological characterization, we found that the mGluR2/3 agonist LY379268, which acts centrally to reduce evoked glutamate release, attenuates context-induced reinstatement of heroin seeking when injected systemically or into the ventral tegmental area, the cell body region of the mesolimbic dopamine system. Here, we tested whether injections of LY379268 into the nucleus accumbens (NAc), a terminal region of the mesolimbic dopamine system, would also attenuate context-induced reinstatement of heroin seeking. Rats were trained to self-administer heroin; drug infusions were paired with a discrete tone-light cue. Subsequently, lever pressing was extinguished in the presence of the discrete cue in a context that differed from the drug self-administration context in terms of visual, auditory, tactile, and circadian cues. After extinction of responding, LY379268 was injected to different groups of rats into the NAc core or shell or into the caudate-putamen, a terminal region of the nigrastriatal dopamine system. Injections of LY379268 into the NAc shell (0.3 or 1.0 microg) dose-dependently attenuated context-induced reinstatement of heroin seeking. Injections of 1.0 microg of LY379268 into the NAc core had no effect, while a higher dose (3.0 microg) decreased this reinstatement. Injections of LY379268 (3.0 microg) 1.5 mm dorsal from the NAc core into the caudate-putamen were ineffective. Results suggest an important role of glutamate transmission in the NAc shell in context-induced reinstatement of heroin seeking. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Bossert, Jennifer M AU - Gray, Sarah M AU - Lu, Lin AU - Shaham, Yavin AD - Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Baltimore, MD 21224, USA. jbossert@intra.nida.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 2197 EP - 2209 VL - 31 IS - 10 SN - 0893-133X, 0893-133X KW - Amino Acids KW - 0 KW - Bridged Bicyclo Compounds, Heterocyclic KW - LY 379268 KW - Narcotics KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor 2 KW - Heroin KW - 70D95007SX KW - Index Medicus KW - Amino Acids -- administration & dosage KW - Animals KW - Rats, Long-Evans KW - Bridged Bicyclo Compounds, Heterocyclic -- administration & dosage KW - Dose-Response Relationship, Drug KW - Enzyme Activation -- physiology KW - Narcotics -- administration & dosage KW - Rats KW - Behavior, Animal -- drug effects KW - Self Administration KW - Enzyme Activation -- drug effects KW - Behavior, Animal -- physiology KW - Extinction, Psychological -- drug effects KW - Secondary Prevention KW - Heroin -- administration & dosage KW - Male KW - Conditioning, Operant -- drug effects KW - Nucleus Accumbens -- drug effects KW - Conditioning, Operant -- physiology KW - Nucleus Accumbens -- physiology KW - Heroin Dependence -- physiopathology KW - Heroin Dependence -- drug therapy KW - Receptors, Metabotropic Glutamate -- physiology KW - Receptors, Metabotropic Glutamate -- agonists UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68868839?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=Activation+of+group+II+metabotropic+glutamate+receptors+in+the+nucleus+accumbens+shell+attenuates+context-induced+relapse+to+heroin+seeking.&rft.au=Bossert%2C+Jennifer+M%3BGray%2C+Sarah+M%3BLu%2C+Lin%3BShaham%2C+Yavin&rft.aulast=Bossert&rft.aufirst=Jennifer&rft.date=2006-10-01&rft.volume=31&rft.issue=10&rft.spage=2197&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Eur J Neurosci. 2000 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U S A. 2000 Apr 11;97(8):4321-6 [10760299] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pretransplant pulmonary function tests predict risk of mortality following fractionated total body irradiation and allogeneic peripheral blood stem cell transplant. AN - 68852145; 16965994 AB - To determine the value of pulmonary function tests (PFTs) done before peripheral blood stem cell transplant (PBSCT) in predicting mortality after total body irradiation (TBI) performed with or without dose reduction to the lung. From 1997 to 2004, 146 consecutive patients with hematologic malignancies received fractionated TBI before PBSCT. With regimen A (n=85), patients were treated without lung dose reduction to 13.6 gray (Gy). In regimen B (n=35), total body dose was decreased to 12 Gy (1.5 Gy twice per day for 4 days) and lung dose was limited to 9 Gy by use of lung shielding. In regimen C (n=26), lung dose was reduced to 6 Gy. All patients received PFTs before treatment, 90 days after treatment, and annually. Median follow-up was 44 months (range, 12-90 months). Sixty-one patients had combined ventilation/diffusion capacity deficits defined as both a forced expiratory volume in the first second (FEV1) and a diffusion capacity of carbon dioxide (DLCO)<100% predicted. In this group, there was a 20% improvement in one-year overall survival with lung dose reduction (70 vs. 50%, log-rank test p=0.042). Among those with combined ventilation/diffusion capacity deficits, lung dose reduction during TBI significantly improved survival. JF - International journal of radiation oncology, biology, physics AU - Singh, Anurag K AU - Karimpour, Shervin E AU - Savani, Bipin N AU - Guion, Peter AU - Hope, Andrew J AU - Mansueti, John R AU - Ning, Holly AU - Altemus, Rosemary M AU - Wu, Colin O AU - Barrett, A John AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. singan@mail.nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 520 EP - 527 VL - 66 IS - 2 SN - 0360-3016, 0360-3016 KW - Index Medicus KW - Respiratory Function Tests KW - Transplantation Conditioning KW - Radiation Protection KW - Radiotherapy Dosage KW - Pulmonary Diffusing Capacity KW - Humans KW - Adult KW - Forced Expiratory Volume KW - Male KW - Female KW - Whole-Body Irradiation -- mortality KW - Hematopoietic Stem Cell Transplantation -- mortality KW - Hematologic Neoplasms -- physiopathology KW - Whole-Body Irradiation -- adverse effects KW - Hematologic Neoplasms -- surgery KW - Lung -- physiopathology KW - Lung -- radiation effects KW - Hematologic Neoplasms -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68852145?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Pretransplant+pulmonary+function+tests+predict+risk+of+mortality+following+fractionated+total+body+irradiation+and+allogeneic+peripheral+blood+stem+cell+transplant.&rft.au=Singh%2C+Anurag+K%3BKarimpour%2C+Shervin+E%3BSavani%2C+Bipin+N%3BGuion%2C+Peter%3BHope%2C+Andrew+J%3BMansueti%2C+John+R%3BNing%2C+Holly%3BAltemus%2C+Rosemary+M%3BWu%2C+Colin+O%3BBarrett%2C+A+John&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-10-01&rft.volume=66&rft.issue=2&rft.spage=520&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of expectation on the brain metabolic responses to methylphenidate and to its placebo in non-drug abusing subjects. AN - 68849247; 16757181 AB - The response to drugs is affected by expectation, which in turn is sensitive to prior drug experiences. Here, we evaluate the effects of expectation on the responses to intravenous methylphenidate (0.5 mg/kg) in fifteen subjects who had minimal experience with stimulant drugs. We used positron emission tomography to measure brain glucose metabolism, which we used as a marker of brain function and tested them under four randomized conditions (1) expecting placebo and receiving placebo; (2) expecting placebo and receiving methylphenidate; (3) expecting methylphenidate and receiving methylphenidate; (4) expecting methylphenidate and receiving placebo. We show that methylphenidate-induced decreases in striatum were greater when subjects expected to receive methylphenidate than when they were not expecting it. We also show that the subjects' expectations affected their responses to placebo. That is, when subjects expected to receive methylphenidate but received placebo there were significant increases in ventral cingulate gyrus (BA 25) and nucleus accumbens (regions involved with emotional reactivity and reward). The effect was largest in subjects who, because of experimental randomization, had not experienced methylphenidate. Because subjects were told that methylphenidate could be experienced as pleasant, unpleasant or devoid of subjective effects these results suggest the involvement of the ventral cingulate and of the nucleus accumbens in processing expectation for "uncertain drug effects". Thus, the state of expectation needs to be considered as a variable modulating the reinforcing and therapeutic effects of drugs even in subjects who have no prior experience with the drug. JF - NeuroImage AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Ma, Yeming AU - Fowler, Joanna S AU - Wong, Christopher AU - Jayne, Millard AU - Telang, Frank AU - Swanson, James M AD - National Institute on Drug Abuse, Bethesda, MD 20892, USA. nvolkow@nida.nih.gov Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 1782 EP - 1792 VL - 32 IS - 4 SN - 1053-8119, 1053-8119 KW - Central Nervous System Stimulants KW - 0 KW - Dopamine Plasma Membrane Transport Proteins KW - Radiopharmaceuticals KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Methylphenidate KW - 207ZZ9QZ49 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Prefrontal Cortex -- diagnostic imaging KW - Set (Psychology) KW - Prefrontal Cortex -- metabolism KW - Humans KW - Dopamine -- physiology KW - Neostriatum -- diagnostic imaging KW - Heart Rate -- drug effects KW - Placebo Effect KW - Reward KW - Adult KW - Neostriatum -- drug effects KW - Heart Rate -- physiology KW - Male KW - Blood Pressure -- physiology KW - Positron-Emission Tomography KW - Gyrus Cinguli -- diagnostic imaging KW - Gyrus Cinguli -- drug effects KW - Brain -- diagnostic imaging KW - Prefrontal Cortex -- drug effects KW - Neostriatum -- metabolism KW - Gyrus Cinguli -- metabolism KW - Dopamine Plasma Membrane Transport Proteins -- metabolism KW - Blood Pressure -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Methylphenidate -- pharmacology KW - Brain Chemistry -- drug effects KW - Substance-Related Disorders -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68849247?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Effects+of+expectation+on+the+brain+metabolic+responses+to+methylphenidate+and+to+its+placebo+in+non-drug+abusing+subjects.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BMa%2C+Yeming%3BFowler%2C+Joanna+S%3BWong%2C+Christopher%3BJayne%2C+Millard%3BTelang%2C+Frank%3BSwanson%2C+James+M&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2006-10-01&rft.volume=32&rft.issue=4&rft.spage=1782&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. AN - 68839864; 16854249 AB - The purpose of this study was to present 12-month and lifetime estimates of the prevalence, sociodemographic and clinical correlates, and psychiatric co-morbidity of DSM-IV cannabis abuse and dependence. Data were derived from a large nationally representative survey (n=43093) of US adults. The prevalence of 12-month and lifetime DSM-IV cannabis abuse (1.1% and 7.2%) exceeded the corresponding rates of cannabis dependence (0.3% and 1.3%). Being male, Native American, widowed/separated/divorced, and residing in the West increased the odds whereas being Black, Asian or Hispanic decreased the odds of cannabis abuse and dependence. Cannabis dependence was significantly associated with low income. Ages of onset for both cannabis use disorders occurred in adolescence and the majority of individuals with these disorders remained untreated. Co-morbidity was high between cannabis use disorders and other Axis I and II disorders. Cannabis use disorders continue to present a widespread and serious personal and public health problem. Native Americans were found to have high rates of cannabis use disorders, warranting closer attention to the mental health needs of this subgroup. Associations between cannabis abuse and dependence and Axis I and II disorders were strong, signaling the need for more comprehensive assessment of individuals with cannabis use disorders. Further controlled treatment studies are needed, especially among co-morbid individuals, in view of growing evidence of the adverse personal, medical and societal impacts of cannabis use disorders in the USA. JF - Psychological medicine AU - Stinson, Frederick S AU - Ruan, W June AU - Pickering, Roger AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-9304, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1447 EP - 1460 VL - 36 IS - 10 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - United States KW - Age of Onset KW - Humans KW - Adult KW - Middle Aged KW - Adolescent KW - Male KW - Female KW - Diagnostic and Statistical Manual of Mental Disorders KW - Comorbidity KW - Prevalence KW - Mental Disorders -- diagnosis KW - Mental Disorders -- epidemiology KW - Marijuana Abuse -- diagnosis KW - Marijuana Abuse -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68839864?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Cannabis+use+disorders+in+the+USA%3A+prevalence%2C+correlates+and+co-morbidity.&rft.au=Stinson%2C+Frederick+S%3BRuan%2C+W+June%3BPickering%2C+Roger%3BGrant%2C+Bridget+F&rft.aulast=Stinson&rft.aufirst=Frederick&rft.date=2006-10-01&rft.volume=36&rft.issue=10&rft.spage=1447&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-24 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - International collaboration on alcoholic liver disease and pancreatitis: opportunities. AN - 68834600; 16958660 JF - Journal of gastroenterology and hepatology AU - Purohit, Vishnudutt AD - Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. vpurohit@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - S107 EP - S108 VL - 21 Suppl 3 SN - 0815-9319, 0815-9319 KW - Index Medicus KW - United States KW - Humans KW - National Institutes of Health (U.S.) KW - Pancreatitis, Alcoholic -- prevention & control KW - Liver Diseases, Alcoholic -- prevention & control KW - International Cooperation KW - Research Support as Topic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68834600?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=International+collaboration+on+alcoholic+liver+disease+and+pancreatitis%3A+opportunities.&rft.au=Purohit%2C+Vishnudutt&rft.aulast=Purohit&rft.aufirst=Vishnudutt&rft.date=2006-10-01&rft.volume=21+Suppl+3&rft.issue=&rft.spage=S107&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The transcriptional response to lipopolysaccharide reveals a role for interferon-gamma in lung neutrophil recruitment. AN - 68831459; 16766576 AB - Neutrophil recruitment to the lung after lipopolysaccharide (LPS; endotoxin) inhalation is primarily dependent on Toll-like receptor 4 (Tlr4) signaling, because it is virtually absent in mice deficient in Tlr4. However, among strains wild type for Tlr4, the magnitude of neutrophil recruitment to the lung after LPS inhalation is variable, suggesting the involvement of genes other than Tlr4. To identify genes associated with the inflammatory response to inhaled LPS, we evaluated the transcriptional response in lungs of 12 inbred strains of mice, 8 which are wild type for Tlr4 and 4 of which lack functional Tlr4. Using the promoter integration in microarray analysis algorithm, we scanned our gene list for transcription factor-binding sites significantly overrepresented among Tlr4 wild-type strains with high neutrophil influx in the lung after LPS inhalation. This analysis identified the interferon (IFN)-stimulated response element (ISRE) as the most overrepresented transcription factor (present in 24% of the promoters) associated with the neutrophil influx to the lower respiratory tract. To test the validity of this observation, we evaluated IFN-gamma-deficient mice and found that the presence of IFN-gamma is essential for robust neutrophil recruitment to the lower respiratory tract and modulation of key regulatory cytokines and chemokines after LPS inhalation. In conclusion, using a genomic approach, we identified the ISRE as a transcriptional element associated with the neutrophil response to inhaled LPS and demonstrated for the first time that IFN-gamma plays a critical role in LPS-induced neutrophil recruitment to the lower airways. JF - American journal of physiology. Lung cellular and molecular physiology AU - Burch, Lauranell H AU - Yang, Ivana V AU - Whitehead, Gregory S AU - Chao, Frank G AU - Berman, Katherine G AU - Schwartz, David A AD - National Institute of Environmental Health Sciences, Division of Pulmonary, Allergy, and Critical Care Medicine, Research Triangle Park, NC 27709, USA. burchl@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - L677 EP - L682 VL - 291 IS - 4 SN - 1040-0605, 1040-0605 KW - Lipopolysaccharides KW - 0 KW - Tlr4 protein, mouse KW - Toll-Like Receptor 4 KW - Transcription Factors KW - Interferon-gamma KW - 82115-62-6 KW - Interferons KW - 9008-11-1 KW - Index Medicus KW - Gene Expression -- drug effects KW - Transcription Factors -- physiology KW - Animals KW - Pneumonia -- chemically induced KW - Pneumonia -- genetics KW - Mice KW - Response Elements -- physiology KW - Mice, Knockout KW - Mice, Inbred Strains KW - Interferons -- physiology KW - Toll-Like Receptor 4 -- deficiency KW - Toll-Like Receptor 4 -- physiology KW - Administration, Inhalation KW - Male KW - Lipopolysaccharides -- administration & dosage KW - Transcription, Genetic -- drug effects KW - Neutrophil Infiltration -- genetics KW - Lipopolysaccharides -- pharmacology KW - Lung -- drug effects KW - Neutrophil Infiltration -- physiology KW - Interferon-gamma -- physiology KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68831459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.atitle=The+transcriptional+response+to+lipopolysaccharide+reveals+a+role+for+interferon-gamma+in+lung+neutrophil+recruitment.&rft.au=Burch%2C+Lauranell+H%3BYang%2C+Ivana+V%3BWhitehead%2C+Gregory+S%3BChao%2C+Frank+G%3BBerman%2C+Katherine+G%3BSchwartz%2C+David+A&rft.aulast=Burch&rft.aufirst=Lauranell&rft.date=2006-10-01&rft.volume=291&rft.issue=4&rft.spage=L677&rft.isbn=&rft.btitle=&rft.title=American+journal+of+physiology.+Lung+cellular+and+molecular+physiology&rft.issn=10400605&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Special remarks from the National Institute on Alcohol Abuse and Alcoholism. AN - 68829986; 16958664 JF - Journal of gastroenterology and hepatology AU - Zakhari, Samir AD - Division of Metabolism and Health Effects, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892-9304, USA. szakhari@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1 VL - 21 Suppl 3 SN - 0815-9319, 0815-9319 KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Biomedical Research KW - Humans KW - United States -- epidemiology KW - Societies, Medical KW - Comorbidity KW - Liver Diseases, Alcoholic -- therapy KW - Pancreatitis, Alcoholic -- therapy KW - Pancreatitis, Alcoholic -- mortality KW - Ethanol -- pharmacology KW - Liver Diseases, Alcoholic -- mortality KW - Ethanol -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68829986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+gastroenterology+and+hepatology&rft.atitle=Special+remarks+from+the+National+Institute+on+Alcohol+Abuse+and+Alcoholism.&rft.au=Zakhari%2C+Samir&rft.aulast=Zakhari&rft.aufirst=Samir&rft.date=2006-10-01&rft.volume=21+Suppl+3&rft.issue=&rft.spage=S2&rft.isbn=&rft.btitle=&rft.title=Journal+of+gastroenterology+and+hepatology&rft.issn=08159319&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-29 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Triazole-polyene antagonism in experimental invasive pulmonary aspergillosis: in vitro and in vivo correlation. AN - 68829285; 16960790 AB - Combination antifungal therapy is increasingly used in the treatment of invasive aspergillosis. Whether the interaction between amphotericin B and triazoles is antagonistic against invasive aspergillosis is a controversial issue that is not likely to be resolved through a randomized clinical trial. Here, we found both in vitro and in vivo antagonism between liposomal amphotericin B and ravuconazole in simultaneous treatment of experimental invasive pulmonary aspergillosis in persistently neutropenic rabbits. Bliss independence-based drug-interaction modeling showed significant antagonism in vitro and in vivo, with the observed drug effects being 20%-69% lower than would be expected if the drugs were acting independently. These in vitro and in vivo findings of antagonism were consistent with the findings from Loewe additivity-based drug-interaction modeling. No pharmacokinetic interaction was found. The combination of a triazole and polyene may be antagonistic in the treatment of invasive pulmonary aspergillosis. JF - The Journal of infectious diseases AU - Meletiadis, Joseph AU - Petraitis, Vidmantas AU - Petraitiene, Ruta AU - Lin, Pengxin AU - Stergiopoulou, Theodouli AU - Kelaher, Amy M AU - Sein, Tin AU - Schaufele, Robert L AU - Bacher, John AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 1008 EP - 1018 VL - 194 IS - 7 SN - 0022-1899, 0022-1899 KW - Antifungal Agents KW - 0 KW - ER 30346 KW - Liposomes KW - Polyenes KW - Thiazoles KW - Triazoles KW - liposomal amphotericin B KW - Amphotericin B KW - 7XU7A7DROE KW - Abridged Index Medicus KW - Index Medicus KW - Drug Therapy, Combination KW - Animals KW - Humans KW - Polyenes -- antagonists & inhibitors KW - Rabbits KW - Polyenes -- pharmacology KW - Drug Antagonism KW - Polyenes -- therapeutic use KW - Models, Biological KW - Microbial Sensitivity Tests KW - Lung Diseases, Fungal -- drug therapy KW - Aspergillosis -- drug therapy KW - Liposomes -- pharmacology KW - Liposomes -- therapeutic use KW - Triazoles -- pharmacology KW - Antifungal Agents -- therapeutic use KW - Thiazoles -- pharmacology KW - Antifungal Agents -- antagonists & inhibitors KW - Antifungal Agents -- pharmacology KW - Triazoles -- antagonists & inhibitors KW - Amphotericin B -- antagonists & inhibitors KW - Aspergillus fumigatus -- drug effects KW - Triazoles -- therapeutic use KW - Amphotericin B -- pharmacology KW - Thiazoles -- antagonists & inhibitors KW - Liposomes -- antagonists & inhibitors KW - Thiazoles -- therapeutic use KW - Amphotericin B -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68829285?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+infectious+diseases&rft.atitle=Triazole-polyene+antagonism+in+experimental+invasive+pulmonary+aspergillosis%3A+in+vitro+and+in+vivo+correlation.&rft.au=Meletiadis%2C+Joseph%3BPetraitis%2C+Vidmantas%3BPetraitiene%2C+Ruta%3BLin%2C+Pengxin%3BStergiopoulou%2C+Theodouli%3BKelaher%2C+Amy+M%3BSein%2C+Tin%3BSchaufele%2C+Robert+L%3BBacher%2C+John%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-10-01&rft.volume=194&rft.issue=7&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+infectious+diseases&rft.issn=00221899&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-09-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains. AN - 68816880; 16777093 AB - We have previously shown that immunization with RPE65 produces in rats of four strains a severe inflammatory eye disease, designated experimental autoimmune uveitis (EAU). Here, we examined the uveitogenicity of RPE65 in six strains of mice. Only one strain, C57Bl/6, was found to develop consistently moderate levels of EAU, whereas other strains (BALB/c, B10.A, B10.BR, B10.RIII, C57BL/10J) were found to be essentially resistant to disease induced by RPE65. Analysis of the expression of RPE65 mRNA in thymi of the six mouse strains revealed detectable levels of the transcript in all strains, but with remarkable quantitative differences, with the lowest levels seen in thymi of C57Bl/6 mice, the only strain susceptible to RPE65-induced EAU. Moreover, unlike the finding with the mice, no RPE65 mRNA was detected in thymi of any of the four rat strains (Lewis, BN, F344, SHR) all of which are susceptible to the disease. These data thus indicate that the susceptibility to RPE65-induced EAU is inversely related to the thymic expression of the molecule. The data also suggest that this disease can be induced only in mice in which thymic expression of RPE65 is sufficiently low to allow the escape from deletion of T-cells with the adequate capacity to initiate the pathogenic immune response. JF - Experimental eye research AU - Ham, Don-Il AU - Fujimoto, Chiaki AU - Gentleman, Susan AU - Chan, Chi-Chao AU - Yu, Cheng-Rong AU - Yu, Shirley AU - Egwuagu, Charles E AU - Michael Redmond, T AU - Gery, Igal AD - Laboratory of Immunology, National Eye Institute, National Institute of Health, Bethesda, MD 20892-1857, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 897 EP - 902 VL - 83 IS - 4 SN - 0014-4835, 0014-4835 KW - Carrier Proteins KW - 0 KW - Eye Proteins KW - RNA, Messenger KW - retinoid isomerohydrolase KW - EC 3.1.1.64 KW - cis-trans-Isomerases KW - EC 5.2.- KW - Index Medicus KW - Animals KW - Disease Susceptibility KW - Gene Expression KW - Mice KW - Reverse Transcriptase Polymerase Chain Reaction -- methods KW - RNA, Messenger -- genetics KW - Immune Tolerance KW - Rats KW - Rats, Inbred Strains KW - Mice, Inbred Strains KW - Species Specificity KW - Female KW - Thymus Gland -- immunology KW - Eye Proteins -- toxicity KW - Eye Proteins -- genetics KW - Thymus Gland -- metabolism KW - Autoimmune Diseases -- metabolism KW - Autoimmune Diseases -- chemically induced KW - Uveitis -- metabolism KW - Uveitis -- immunology KW - Eye Proteins -- biosynthesis KW - Uveitis -- chemically induced KW - Autoimmune Diseases -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68816880?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Experimental+eye+research&rft.atitle=The+level+of+thymic+expression+of+RPE65+inversely+correlates+with+its+capacity+to+induce+experimental+autoimmune+uveitis+%28EAU%29+in+different+rodent+strains.&rft.au=Ham%2C+Don-Il%3BFujimoto%2C+Chiaki%3BGentleman%2C+Susan%3BChan%2C+Chi-Chao%3BYu%2C+Cheng-Rong%3BYu%2C+Shirley%3BEgwuagu%2C+Charles+E%3BMichael+Redmond%2C+T%3BGery%2C+Igal&rft.aulast=Ham&rft.aufirst=Don-Il&rft.date=2006-10-01&rft.volume=83&rft.issue=4&rft.spage=897&rft.isbn=&rft.btitle=&rft.title=Experimental+eye+research&rft.issn=00144835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NMDA and non-NMDA receptors stimulation causes differential oxidative stress in rat cortical slices. AN - 68745707; 16860439 AB - Glutamate receptor activated neuronal cell death is attributed to a massive influx of Ca(2+) and subsequent formation of reactive oxygen species (ROS) but the relative contribution of NMDA and non-NMDA sub-types of glutamate receptors in excitotoxicity is not known. In the present study, we have examined the role of NMDA and non-NMDA receptors in glutamate-induced neuronal injury in cortical slices from young (20+/-2 day) and adult (80+/-5 day) rats. Treatment of slices with glutamate receptor agonists NMDA, AMPA and KA elicited the formation of reactive oxygen species (ROS) and neuronal cell death. In young slices, NMDA receptor stimulation caused a higher ROS formation and neurotoxicity, but KA was more effective in producing ROS and cell death in adult slices. AMPA exhibited an intermediate effect on ROS formation and toxicity in both the age groups. A significant protection in glutamate mediated ROS formation and neurotoxicity was observed in presence of NMDA or/and non-NMDA receptors antagonists APV and NBQX, respectively. This further confirms the involvement of both NMDA and non-NMDA receptors in glutamate mediated neurotoxicity. In adult slices, we did not find positive correlation between ligand induced neurotoxicity and mitochondrial depolarization. Though, NMDA and KA stimulation produced differential effect on ROS formation and neurotoxicity in young and adult slices, the mitochondrial depolarization was higher and comparable on NMDA stimulation in both the age groups as compared to KA, suggesting that the mitochondrial depolarization may not be a good indicator for neurotoxicity. Our results demonstrate that both NMDA and non-NMDA sub-types of glutamate receptors are involved in glutamate mediated neurotoxicity but their relative contribution is highly dependent on the age of the animal. JF - Neurochemistry international AU - Sanganahalli, Basavaraju G AU - Joshi, Preeti G AU - Joshi, Nanda B AD - Department of Biophysics, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 475 EP - 480 VL - 49 IS - 5 SN - 0197-0186, 0197-0186 KW - Reactive Oxygen Species KW - 0 KW - Receptors, N-Methyl-D-Aspartate KW - N-Methylaspartate KW - 6384-92-5 KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid KW - 77521-29-0 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Kainic Acid KW - SIV03811UC KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Kainic Acid -- pharmacology KW - Spectrometry, Fluorescence KW - N-Methylaspartate -- pharmacology KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid -- pharmacology KW - L-Lactate Dehydrogenase -- metabolism KW - Cerebral Cortex -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- agonists KW - Cerebral Cortex -- metabolism KW - Cerebral Cortex -- enzymology KW - Oxidative Stress UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68745707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurochemistry+international&rft.atitle=NMDA+and+non-NMDA+receptors+stimulation+causes+differential+oxidative+stress+in+rat+cortical+slices.&rft.au=Sanganahalli%2C+Basavaraju+G%3BJoshi%2C+Preeti+G%3BJoshi%2C+Nanda+B&rft.aulast=Sanganahalli&rft.aufirst=Basavaraju&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=475&rft.isbn=&rft.btitle=&rft.title=Neurochemistry+international&rft.issn=01970186&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-18 N1 - Date created - 2006-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Black tea polyphenols restrict benzopyrene-induced mouse lung cancer progression through inhibition of Cox-2 and induction of caspase-3 expression. AN - 68302742; 17250449 AB - Lung cancer is one of the leading causes of cancer related death in most developed and many developing countries of the world. Due to lack of validated screening methods and poor prognosis, treatment of lung cancer has not improved significantly over the last two decades. Therefore the risk of the disease needs to be minimized by preventive measures. One approach for lung cancer prevention envisages reversal or restriction of precancerous lesions by chemopreventive intervention. It demands a deeper understanding of the pathogenesis of the disease and identification of the ideal point of intervention. In the present investigation, tea components, epigallocatechin gallate (EGCG) and theaflavins (TF) were assessed for their chemopreventive potential when administered in the post initiation phase of lung carcinogenesis in an experimental mouse model. Histopathological changes in lungs of mice administered benzo(a)pyrene (BP) were followed serially and correlated with the expression of Cox-2, caspase-3 and caspase-7, which play key roles in histopathogenesis of neoplasia. The observations strongly indicate that both EGCG and TF can influence the expression of these genes to modulate the process of carcinogenesis, resulting in delayed onset and lowered incidence of pre-invasive lung lesions. JF - Asian Pacific journal of cancer prevention : APJCP AU - Banerjee, Sarmistha AU - Manna, Sugata AU - Mukherjee, Sudeshna AU - Pal, Debalina AU - Panda, Chinmay Kr AU - Das, Sukta AD - Department of Oncogene Regulation, Chittarajan National Cancer Institute, Kolkata 700026, India. PY - 2006 SP - 661 EP - 666 VL - 7 IS - 4 SN - 1513-7368, 1513-7368 KW - Benzopyrenes KW - 0 KW - Biflavonoids KW - Flavonoids KW - Phenols KW - Polyphenols KW - Tea KW - theaflavin KW - 1IA46M0D13 KW - Catechin KW - 8R1V1STN48 KW - epigallocatechin gallate KW - BQM438CTEL KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Caspase 3 KW - EC 3.4.22.- KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals, Newborn KW - Animals KW - Blotting, Western KW - Catechin -- analogs & derivatives KW - Disease Progression KW - Biflavonoids -- pharmacology KW - Mice KW - Catechin -- pharmacology KW - Lung Neoplasms -- prevention & control KW - Phenols -- pharmacology KW - Cyclooxygenase 2 -- drug effects KW - Tea -- chemistry KW - Lung Neoplasms -- chemically induced KW - Flavonoids -- pharmacology KW - Caspase 3 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68302742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.atitle=Black+tea+polyphenols+restrict+benzopyrene-induced+mouse+lung+cancer+progression+through+inhibition+of+Cox-2+and+induction+of+caspase-3+expression.&rft.au=Banerjee%2C+Sarmistha%3BManna%2C+Sugata%3BMukherjee%2C+Sudeshna%3BPal%2C+Debalina%3BPanda%2C+Chinmay+Kr%3BDas%2C+Sukta&rft.aulast=Banerjee&rft.aufirst=Sarmistha&rft.date=2006-10-01&rft.volume=7&rft.issue=4&rft.spage=661&rft.isbn=&rft.btitle=&rft.title=Asian+Pacific+journal+of+cancer+prevention+%3A+APJCP&rft.issn=15137368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-15 N1 - Date created - 2007-01-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. AN - 68255774; 17112570 AB - Non-peptidic delta opioid receptor agonists are being evaluated for a wide range of clinical applications; however, the clinical utility of piperazinyl benzamide delta agonists such as SNC80 may be limited by convulsant activity. The purpose of the present study was to evaluate the electroencephalographic and convulsant activity produced by a high dose of 10 mg/kg SNC80 IM in rhesus monkeys. EEG and behavioral activity were examined in four adult male rhesus monkeys after IM administration of SNC80. Monkeys were seated in a standard primate restraint chair, and EEG activity was recorded using an array of 16 needle electrodes implanted subcutaneously in the scalp in a bipolar (scalp-to-scalp) montage in a longitudinal direction, with bilateral frontal, central, temporal, and occipital leads. Behavior was recorded using video monitoring equipment. Initially, all monkeys were tested with 10 mg/kg SNC80, which is a relatively high dose 3-10-fold greater than doses necessary to produce a variety of other behavioral effects. Behavioral convulsions and EEG seizures were observed in one of the four monkeys. In this monkey, neither behavioral convulsions nor EEG seizures were observed when a lower dose of 3.2 mg/kg was administered nine weeks later or when the same dose of 10 mg/kg SNC80 was administered one year later. These results suggest that IM administration of SNC80 is less potent in producing convulsant effects than in producing other, potentially useful behavioral effects (e.g. antinociception) in rhesus monkeys. JF - Pharmacology, biochemistry, and behavior AU - Danielsson, Ingela AU - Gasior, Maciej AU - Stevenson, Glenn W AU - Folk, John E AU - Rice, Kenner C AU - Negus, S Stevens AD - Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, NIH, United States; Cyberonics, Houston, TX, USA. Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 428 EP - 434 VL - 85 IS - 2 SN - 0091-3057, 0091-3057 KW - Benzamides KW - 0 KW - Piperazines KW - Receptors, Opioid, delta KW - 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide KW - 156727-74-1 KW - Index Medicus KW - Animals KW - Macaca mulatta KW - Male KW - Seizures -- chemically induced KW - Benzamides -- pharmacology KW - Receptors, Opioid, delta -- agonists KW - Electroencephalography -- drug effects KW - Piperazines -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68255774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology%2C+biochemistry%2C+and+behavior&rft.atitle=Electroencephalographic+and+convulsant+effects+of+the+delta+opioid+agonist+SNC80+in+rhesus+monkeys.&rft.au=Danielsson%2C+Ingela%3BGasior%2C+Maciej%3BStevenson%2C+Glenn+W%3BFolk%2C+John+E%3BRice%2C+Kenner+C%3BNegus%2C+S+Stevens&rft.aulast=Danielsson&rft.aufirst=Ingela&rft.date=2006-10-01&rft.volume=85&rft.issue=2&rft.spage=428&rft.isbn=&rft.btitle=&rft.title=Pharmacology%2C+biochemistry%2C+and+behavior&rft.issn=00913057&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-12-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Med Chem. 1994 Jul 8;37(14):2125-8 [8035418] J Pharmacol Exp Ther. 1993 Nov;267(2):875-82 [8246162] J Pharmacol Exp Ther. 1995 Apr;273(1):359-66 [7714789] Cell Mol Neurobiol. 1995 Dec;15(6):615-35 [8719033] Neurochem Res. 1996 Nov;21(11):1333-45 [8947923] J Pharmacol Exp Ther. 1998 Jul;286(1):362-75 [9655881] Neuroscience. 1999;88(4):1093-135 [10336124] J Pharmacol Exp Ther. 1999 Sep;290(3):1157-64 [10454490] Brain Res. 2005 Feb 1;1033(1):1-12 [15680333] J Pharmacol Exp Ther. 2006 Jun;317(3):1337-48 [16537798] J Pharmacol Exp Ther. 2006 Nov;319(2):507-14 [16751251] J Pharmacol Exp Ther. 1993 Nov;267(2):888-95 [8246164] J Pharmacol Exp Ther. 1994 Sep;270(3):1025-34 [7932149] J Pharmacol Exp Ther. 1993 Nov;267(2):852-7 [8246159] Trends Neurosci. 1988 Jul;11(7):308-14 [2465635] J Neurosci. 1987 Aug;7(8):2445-64 [3039080] Nature. 1977 Jun 9;267(5611):495-9 [195217] J Pharmacol Exp Ther. 1976 Jun;197(3):517-32 [945347] J Pharmacol Exp Ther. 2004 Apr;309(1):173-81 [14722329] Epileptic Disord. 2003 Sep;5(3):149-56 [14684350] J Comp Neurol. 2003 Oct 20;465(3):349-60 [12966560] J Pharmacol Exp Ther. 2002 Nov;303(2):723-9 [12388657] Psychopharmacology (Berl). 2002 Oct;164(1):42-8 [12373418] J Pharmacol Exp Ther. 2002 Feb;300(2):435-41 [11805202] J Pharmacol Exp Ther. 2001 Nov;299(2):629-37 [11602675] Brain Res. 2001 Mar 2;893(1-2):121-34 [11223000] J Pharmacol Exp Ther. 2001 Mar;296(3):939-46 [11181927] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Nuclear receptors CAR and PXR in the regulation of hepatic metabolism. AN - 68179593; 17118922 AB - The nuclear receptors CAR and PXR were first characterized as xenosensing transcription factors regulating the induction of phase I and II xenobiotic-metabolizing enzymes as well as transporters in response to exogenous stimuli. It has now become clear, however, that these receptors cross-talk with endogenous stimuli as well, which extends their regulation to various physiological processes such as energy metabolism and cell growth. As recognition of the function of these receptors has widened, the molecular mechanism of their regulation has evolved from simple protein-DNA binding to regulation by complex protein-protein interactions. Novel mechanisms as to how xenobiotic exposure alters hepatic metabolic pathways such as gluconeogenesis and beta-oxidation have emerged. At the same time, the molecular mechanism of how endogenous stimuli, such as insulin, regulate xenobiotc metabolism via CAR and PXR have also become evident. JF - Xenobiotica; the fate of foreign compounds in biological systems AU - Tien, E S AU - Negishi, M AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. PY - 2006 SP - 1152 EP - 1163 VL - 36 IS - 10-11 SN - 0049-8254, 0049-8254 KW - CLMP protein, human KW - 0 KW - Coxsackie and Adenovirus Receptor-Like Membrane Protein KW - Receptors, Cytoplasmic and Nuclear KW - Receptors, Steroid KW - Receptors, Virus KW - pregnane X receptor KW - Index Medicus KW - Animals KW - Inactivation, Metabolic KW - Endocrine System -- physiology KW - Humans KW - Homeostasis KW - Energy Metabolism KW - Cell Growth Processes KW - Signal Transduction KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Receptors, Steroid -- metabolism KW - Liver -- metabolism KW - Receptors, Virus -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68179593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.atitle=Nuclear+receptors+CAR+and+PXR+in+the+regulation+of+hepatic+metabolism.&rft.au=Tien%2C+E+S%3BNegishi%2C+M&rft.aulast=Tien&rft.aufirst=E&rft.date=2006-10-01&rft.volume=36&rft.issue=10-11&rft.spage=1152&rft.isbn=&rft.btitle=&rft.title=Xenobiotica%3B+the+fate+of+foreign+compounds+in+biological+systems&rft.issn=00498254&rft_id=info:doi/ LA - 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Last updated - 2017-01-18 ER - TY - JOUR T1 - Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. AN - 68172692; 17118889 AB - The Cancer Imaging Program of the National Cancer Institute convened a workshop to assess the current status of hypoxia imaging, to assess what is known about the biology of hypoxia as it relates to cancer and cancer therapy, and to define clinical scenarios in which in vivo hypoxia imaging could prove valuable. Hypoxia, or low oxygenation, has emerged as an important factor in tumor biology and response to cancer treatment. It has been correlated with angiogenesis, tumor aggressiveness, local recurrence, and metastasis, and it appears to be a prognostic factor for several cancers, including those of the cervix, head and neck, prostate, pancreas, and brain. The relationship between tumor oxygenation and response to radiation therapy has been well established, but hypoxia also affects and is affected by some chemotherapeutic agents. Although hypoxia is an important aspect of tumor physiology and response to treatment, the lack of simple and efficient methods to measure and image oxygenation hampers further understanding and limits their prognostic usefulness. There is no gold standard for measuring hypoxia; Eppendorf measurement of pO(2) has been used, but this method is invasive. Recent studies have focused on molecular markers of hypoxia, such as hypoxia inducible factor 1 (HIF-1) and carbonic anhydrase isozyme IX (CA-IX), and on developing noninvasive imaging techniques. This workshop yielded recommendations on using hypoxia measurement to identify patients who would respond best to radiation therapy, which would improve treatment planning. This represents a narrow focus, as hypoxia measurement might also prove useful in drug development and in increasing our understanding of tumor biology. JF - International journal of radiation biology AU - Tatum, James L AU - Kelloff, Gary J AU - Gillies, Robert J AU - Arbeit, Jeffrey M AU - Brown, J Martin AU - Chao, K S Clifford AU - Chapman, J Donald AU - Eckelman, William C AU - Fyles, Anthony W AU - Giaccia, Amato J AU - Hill, Richard P AU - Koch, Cameron J AU - Krishna, Murali Cherukuri AU - Krohn, Kenneth A AU - Lewis, Jason S AU - Mason, Ralph P AU - Melillo, Giovanni AU - Padhani, Anwar R AU - Powis, Garth AU - Rajendran, Joseph G AU - Reba, Richard AU - Robinson, Simon P AU - Semenza, Gregg L AU - Swartz, Harold M AU - Vaupel, Peter AU - Yang, David AU - Croft, Barbara AU - Hoffman, John AU - Liu, Guoying AU - Stone, Helen AU - Sullivan, Daniel AD - National Cancer Institute, Executive Plaza North, Room 6000, 6130 Executive Boulevard, Rockville, MD 20852-7440, USA. tatumj@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 699 EP - 757 VL - 82 IS - 10 SN - 0955-3002, 0955-3002 KW - Antigens, Neoplasm KW - 0 KW - Biomarkers, Tumor KW - Hypoxia-Inducible Factor 1 KW - Isoenzymes KW - CA9 protein, human KW - EC 4.2.1.1 KW - Carbonic Anhydrase IX KW - Carbonic Anhydrases KW - Oxygen KW - S88TT14065 KW - Index Medicus KW - Space life sciences KW - United States KW - Hypoxia-Inducible Factor 1 -- metabolism KW - Reproducibility of Results KW - Humans KW - National Institutes of Health (U.S.) KW - Prognosis KW - Biomarkers, Tumor -- analysis KW - Carbonic Anhydrases -- metabolism KW - Antigens, Neoplasm -- metabolism KW - Radiography KW - Isoenzymes -- metabolism KW - Neoplasms -- drug therapy KW - Neoplasms -- pathology KW - Neoplasms -- diagnostic imaging KW - Oxygen -- metabolism KW - Hypoxia -- diagnosis KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Diagnostic Imaging -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68172692?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+biology&rft.atitle=Hypoxia%3A+importance+in+tumor+biology%2C+noninvasive+measurement+by+imaging%2C+and+value+of+its+measurement+in+the+management+of+cancer+therapy.&rft.au=Tatum%2C+James+L%3BKelloff%2C+Gary+J%3BGillies%2C+Robert+J%3BArbeit%2C+Jeffrey+M%3BBrown%2C+J+Martin%3BChao%2C+K+S+Clifford%3BChapman%2C+J+Donald%3BEckelman%2C+William+C%3BFyles%2C+Anthony+W%3BGiaccia%2C+Amato+J%3BHill%2C+Richard+P%3BKoch%2C+Cameron+J%3BKrishna%2C+Murali+Cherukuri%3BKrohn%2C+Kenneth+A%3BLewis%2C+Jason+S%3BMason%2C+Ralph+P%3BMelillo%2C+Giovanni%3BPadhani%2C+Anwar+R%3BPowis%2C+Garth%3BRajendran%2C+Joseph+G%3BReba%2C+Richard%3BRobinson%2C+Simon+P%3BSemenza%2C+Gregg+L%3BSwartz%2C+Harold+M%3BVaupel%2C+Peter%3BYang%2C+David%3BCroft%2C+Barbara%3BHoffman%2C+John%3BLiu%2C+Guoying%3BStone%2C+Helen%3BSullivan%2C+Daniel&rft.aulast=Tatum&rft.aufirst=James&rft.date=2006-10-01&rft.volume=82&rft.issue=10&rft.spage=699&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+biology&rft.issn=09553002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reporting of non-communicable disease research in low- and middle-income countries: a pilot bibliometric analysis. AN - 57690392; 477773 AB - Objective: The paper identifies the relative amount of research devoted to non-communicable disease in low- and middle-income countries (LMICs). Design: A bibliometric analysis of a subset of journals published in LMICs was performed. Measurements: Seventy-six peer-reviewed journals focused on general medicine or public health published in 46 LMICs and indexed from 1998 to 2003 in MEDLINE. A total of 24 journals were selected, 4 journals from each of 6 LMIC regions. Searches were refined using 18 non-communicable disease topics with 7,012 articles identified for analysis. Results: More than 40 per cent of articles in LMIC regions focused on non-communicable disease research. The percentage was highest in Eastern Europe/Central Asia (47 per cent) and lowest in Latin America (36 per cent). The percentage of articles published in Sub-Saharan Africa (38 per cent) did not differ significantly from that of Latin America or South Asia. Cardiovascular disease and cancer led the list of the top ten most-indexed published topics by region. Conclusions: Even in regions rampant with infectious diseases, some capability exists to conduct research on non-communicable diseases. Greater attention should be paid to the conduct and support of such research in LMICs, which will benefit these countries and may yield clues to lower-cost solutions to the burden of these diseases worldwide. (Author abstract) JF - Journal of the Medical Library Association ( JMLA ) AU - Hofman, Karen AU - Ryce, Andrea AU - Prudhomme, Wendy AU - Kotzin, Sheldon AD - National Institutes of Health, Bethesda, MD, USA hofmank@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 PB - Medical Library Association VL - 94 IS - 4 SN - 1536-5050, 1536-5050 KW - Bibliometrics KW - Health care KW - Periodicals KW - Medicine KW - Articles KW - Non communicable diseases KW - 5.24: BIBLIOMETRICS, SCIENTOMETRICS, INFORMETRICS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57690392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=Reporting+of+non-communicable+disease+research+in+low-+and+middle-income+countries%3A+a+pilot+bibliometric+analysis.&rft.au=Hofman%2C+Karen%3BRyce%2C+Andrea%3BPrudhomme%2C+Wendy%3BKotzin%2C+Sheldon&rft.aulast=Hofman&rft.aufirst=Karen&rft.date=2006-10-01&rft.volume=94&rft.issue=4&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Bibliometrics; Health care; Medicine; Non communicable diseases; Periodicals; Articles ER - TY - JOUR T1 - A blended training approach using videoconferencing for distance education. AN - 57674639; 477785 AB - In 2004, the National Library of Medicine (NLM) recognized the need to expand its outreach activities to minority students. To meet this objective, NLM sponsored a programme presenting information on varied health sciences topics to minority students interested in health sciences careers. An existing initiative, NLM's Adopt-A-School programme, provided an initial foundation for this project. As part of the Adopt-A-School programme, NLM staff provide training at a nearby school site, and students make field trips to the library. In addition, summer work opportunities are provided for some students. To explore the feasibility of providing a more flexible variant of this programme that would extend the training component to more distant schools, NLM partnered with King Drew Medical Magnet High School in Los Angeles to deliver a distance learning programme via synchronous videoconferencing and collaboration technologies. Describes the approaches used in and the preliminary evaluation of the training. (Quotes from original text) JF - Journal of the Medical Library Association ( JMLA ) AU - Locatis, Craig AU - Gaines, Cynthia AU - Liu, Wei-Li AU - Gill, Michael AU - Carney, John AU - Foster, Jaimela AU - McCall, Valerie AU - Woods, Michelle AD - National Library of Medicine, Bethesda, MD, USA locatis@nlm.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 PB - Medical Library Association VL - 94 IS - 4 SN - 1536-5050, 1536-5050 KW - Distance learning KW - Teleconferencing KW - National libraries KW - Videoconferencing KW - National Library of Medicine KW - Students KW - World Wide Web KW - Computer assisted instruction KW - USA KW - Education KW - Teaching KW - Health care KW - Educational technology KW - Medical libraries KW - Medicine KW - 17.11: EDUCATION UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57674639?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=A+blended+training+approach+using+videoconferencing+for+distance+education.&rft.au=Locatis%2C+Craig%3BGaines%2C+Cynthia%3BLiu%2C+Wei-Li%3BGill%2C+Michael%3BCarney%2C+John%3BFoster%2C+Jaimela%3BMcCall%2C+Valerie%3BWoods%2C+Michelle&rft.aulast=Locatis&rft.aufirst=Craig&rft.date=2006-10-01&rft.volume=94&rft.issue=4&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2007-02-27 N1 - Document feature - il. tbls. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Education; Health care; Medicine; Teaching; Educational technology; Computer assisted instruction; Students; Distance learning; World Wide Web; Videoconferencing; Teleconferencing; National libraries; Medical libraries; USA; National Library of Medicine ER - TY - JOUR T1 - Alterations in CNS Activity Induced by Botulinum Toxin Treatment in Spasmodic Dysphonia: An H2(15)0 PET Study AN - 57113932; 200707727 AB - Speech-related changes in regional cerebral blood flow (rCBF) were measured using H2(15)O positron-emission tomography in 9 adults with adductor spasmodic dysphonia (ADSD) before & after botulinum toxin (BTX) injection & 10 age- & gender-matched volunteers without neurological disorders. Scans were acquired at rest & during production of continuous narrative speech & whispered speech. Speech was recorded during scan acquisition for offline quantification of voice breaks, pitch breaks, & percentage aperiodicity to assess correlations between treatment-related changes in rCBF & clinical improvement. Results demonstrated that speech-related responses in heteromodal sensory areas were significantly reduced in persons with ADSD, compared with volunteers, before the administration of BTX. Three to 4 weeks after BTX injection, speech-related responses were significantly augmented in these regions & in left hemisphere motor areas commonly associated with oral-laryngeal motor control. This pattern of responses was most strongly correlated with the objective measures of clinical improvement (decreases in the frequency of voice breaks, pitch breaks, & percentage aperiodicity). These data suggest a pathophysiological model for ADSD in which BTX treatment results in more efficient cortical processing of sensory information, making this information available to motor areas that use it to more effectively regulate laryngeal movements. Tables, Figures, References. Adapted from the source document. JF - Journal of Speech, Language, and Hearing Research AU - Ali, S Omar AU - Thomassen, Michael AU - Schulz, Geralyn M AU - Hosey, Lara A AU - Varga, Mary AU - Ludlow, Christy L AU - Braun, Allen R AD - c/o Braun -- Language Section, Voice/Speech/Language Branch, National Instit Deafness & Other Communication Disorders, National Instits Health, Bethesda, MD Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 1127 EP - 1146 PB - American Speech-Language-Hearing Association, Rockville MD VL - 49 IS - 5 SN - 1092-4388, 1092-4388 KW - adductor spasmodic dysphonia, botulinum toxin, CNS, rCBF, PET KW - Dysphonia KW - Central nervous system KW - Brain KW - Positron emission tomography KW - Botulinum toxin KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57113932?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.atitle=Alterations+in+CNS+Activity+Induced+by+Botulinum+Toxin+Treatment+in+Spasmodic+Dysphonia%3A+An+H2%2815%290+PET+Study&rft.au=Ali%2C+S+Omar%3BThomassen%2C+Michael%3BSchulz%2C+Geralyn+M%3BHosey%2C+Lara+A%3BVarga%2C+Mary%3BLudlow%2C+Christy+L%3BBraun%2C+Allen+R&rft.aulast=Ali&rft.aufirst=S&rft.date=2006-10-01&rft.volume=49&rft.issue=5&rft.spage=1127&rft.isbn=&rft.btitle=&rft.title=Journal+of+Speech%2C+Language%2C+and+Hearing+Research&rft.issn=10924388&rft_id=info:doi/10.1044%2F1092-4388%282006%2F081%29 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Dysphonia; Botulinum toxin; Central nervous system; Positron emission tomography; Brain DO - http://dx.doi.org/10.1044/1092-4388(2006/081) ER - TY - JOUR T1 - Persistent Psychological Distress in Long-Term Survivors of Pediatric Sarcoma: The Experience at a Single Institution AN - 57092714; 200701418 AB - Background: The long-term psychological impact of pediatric sarcoma is largely unknown. As part of a cross-sectional study examining the late effects of pediatric sarcoma therapy, we examined whether psychological distress or posttraumatic stress symptoms are present in an adult cohort of pediatric sarcoma survivors. Method: Thirty-four patients participated in the study, an average of 17 years after their treatment ended, each completing the SCID module for Posttraumatic Stress Disorder, Impact of Events Scale, Brief Symptom Inventory (BSI) & a questionnaire assessing sociodemographic variables & psychosocial issues. Results: Significant persistent psychological distress characterized this cohort of patients. Seventy-seven percent scored in the clinical range on the BSI. Twelve percent met diagnostic criteria for PTSD. Current psychological distress was associated with intrusive thoughts & avoidant behaviors, male gender, employment, difficulty readjusting to work/school after treatment, & enduring worries about health. No differences were found based on age, presence of metastatic disease or time since diagnosis. Conclusions: This is the first report of a clinical evaluation of psychological distress in a cohort of pediatric sarcoma survivors treated with intensive multimodal cancer therapy. The results suggest that survivors of pediatric sarcoma might be at high risk for adverse psychological outcomes. Appropriate interventions are proposed. Tables, Figures, References. [Copyright 2006 John Wiley and Sons, Ltd.] JF - Psycho-Oncology AU - Wiener, Lori AU - Battles, Haven AU - Bernstein, Donna AU - Long, Lauren AU - Derdak, Joanne AU - Mackall, Crystal L AU - Mansky, Patrick J AD - Pediatic Oncology Branch, National Cancer Instit, Center Cancer Research, National Instits Health wienerl@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 898 EP - 910 PB - John Wiley, Chichester UK VL - 15 IS - 10 SN - 1057-9249, 1057-9249 KW - psychological distress KW - posttraumatic stress KW - pediatric sarcoma KW - long-term survivors KW - intensive treatment KW - cancer KW - oncology KW - Childhood experiences KW - Sarcomas KW - Paediatrics KW - Posttraumatic stress disorder KW - Long term survivors KW - Psychological distress KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57092714?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psycho-Oncology&rft.atitle=Persistent+Psychological+Distress+in+Long-Term+Survivors+of+Pediatric+Sarcoma%3A+The+Experience+at+a+Single+Institution&rft.au=Wiener%2C+Lori%3BBattles%2C+Haven%3BBernstein%2C+Donna%3BLong%2C+Lauren%3BDerdak%2C+Joanne%3BMackall%2C+Crystal+L%3BMansky%2C+Patrick+J&rft.aulast=Wiener&rft.aufirst=Lori&rft.date=2006-10-01&rft.volume=15&rft.issue=10&rft.spage=898&rft.isbn=&rft.btitle=&rft.title=Psycho-Oncology&rft.issn=10579249&rft_id=info:doi/10.1002%2Fpon.1024 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-01-08 N1 - Last updated - 2016-09-27 N1 - CODEN - POJCEE N1 - SubjectsTermNotLitGenreText - Psychological distress; Long term survivors; Posttraumatic stress disorder; Paediatrics; Sarcomas; Childhood experiences DO - http://dx.doi.org/10.1002/pon.1024 ER - TY - JOUR T1 - Geochemical evidence for the variation of historical seabird population on Dongdao Island of the South China Sea AN - 51496344; 2007-014763 JF - Journal of Paleolimnology AU - Liu, X D AU - Zhao, S P AU - Sun, L G AU - Luo, H H AU - Yin, X B AU - Xie, Z Q AU - Wang, Y H AU - Liu, K X AU - Wu, X H AU - Ding, X F AU - Fu, D P Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 259 EP - 279 PB - Springer, Dordrecht VL - 36 IS - 3 SN - 0921-2728, 0921-2728 KW - lithostratigraphy KW - isotopes KW - paleoclimatology KW - Holocene KW - cores KW - West Pacific KW - paleoecology KW - Cenozoic KW - radioactive isotopes KW - Dongdao Island KW - carbon KW - sediments KW - absolute age KW - Northwest Pacific KW - chemical composition KW - South China Sea KW - Chordata KW - Quaternary KW - statistical analysis KW - correlation coefficient KW - Aves KW - populations KW - North Pacific KW - Pacific Ocean KW - lacustrine environment KW - islands KW - Cattle Pond KW - C-14 KW - Vertebrata KW - upper Holocene KW - sea-surface temperature KW - Tetrapoda KW - lake sediments KW - 24:Quaternary geology KW - 11:Vertebrate paleontology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/51496344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ageorefmodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Paleolimnology&rft.atitle=Geochemical+evidence+for+the+variation+of+historical+seabird+population+on+Dongdao+Island+of+the+South+China+Sea&rft.au=Liu%2C+X+D%3BZhao%2C+S+P%3BSun%2C+L+G%3BLuo%2C+H+H%3BYin%2C+X+B%3BXie%2C+Z+Q%3BWang%2C+Y+H%3BLiu%2C+K+X%3BWu%2C+X+H%3BDing%2C+X+F%3BFu%2C+D+P&rft.aulast=Liu&rft.aufirst=X&rft.date=2006-10-01&rft.volume=36&rft.issue=3&rft.spage=259&rft.isbn=&rft.btitle=&rft.title=Journal+of+Paleolimnology&rft.issn=09212728&rft_id=info:doi/10.1007%2Fs10933-006-9006-9 L2 - http://www.springerlink.com/(i42ivkufd5oczp45mspwbbyb)/app/home/journal.asp?referrer=parent&backto=linkingpublicationresults,1:100294,1 LA - English DB - GeoRef N1 - Copyright - GeoRef, Copyright 2012, American Geosciences Institute. N1 - Date revised - 2007-01-01 N1 - Number of references - 93 N1 - Document feature - illus. incl. sect., strat. cols., 4 tables, geol. sketch map N1 - Last updated - 2012-06-07 N1 - SubjectsTermNotLitGenreText - absolute age; Aves; C-14; carbon; Cattle Pond; Cenozoic; chemical composition; Chordata; cores; correlation coefficient; Dongdao Island; Holocene; islands; isotopes; lacustrine environment; lake sediments; lithostratigraphy; North Pacific; Northwest Pacific; Pacific Ocean; paleoclimatology; paleoecology; populations; Quaternary; radioactive isotopes; sea-surface temperature; sediments; South China Sea; statistical analysis; Tetrapoda; upper Holocene; Vertebrata; West Pacific DO - http://dx.doi.org/10.1007/s10933-006-9006-9 ER - TY - JOUR T1 - Living environment and schooling of children with HIV-infected parents in southwest China AN - 36576161; 3379959 AB - A cross-sectional household survey was conducted in Longchuan County, China, to study the lives of children with HIV-infected parents. Registered HI-infected drug users and their households were approached and information about the living environment of children <= 15 years of age was collected. Of the 266 households interviewed, there were 213 children <= 15 years old. Forty percent of the children had lost at least one parent. Most of the children resided in a household with low economic status and a high dependency ratio. One-half of the children experienced discordant family relations, family anxiety and shame. Compared to orphans, non-orphans and their families were less likely to receive social support from the community. Orphans and older children were less likely to attend school and more likely to be truant if enrolled in school. Findings in the current study suggest that many children whose parents are infected with HIV or have died from HIV are living in stressful environments with minimal support from the community. Efforts should be taken to provide support and supervision to these children. Reprinted by permission of Routledge, Taylor & Francis Ltd. JF - AIDS care AU - Yang, H AU - Wu, Z. AU - Duan, S AU - Li, Z. AU - Li, X. AU - Shen, M AU - Mathur, A AU - Stanton, B AD - Wayne State University ; National Center for AIDS/STD Control and Prevention, China ; Dehong Prefecture Anti-Epidemic Station, China ; Longchuan County Anti-Epidemic Station, China ; National Cancer Institute, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 647 EP - 655 VL - 18 IS - 7 SN - 0954-0121, 0954-0121 KW - Sociology KW - Social support KW - Households KW - Drug users KW - Living conditions KW - HIV KW - Parents KW - Children KW - China UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36576161?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+care&rft.atitle=Living+environment+and+schooling+of+children+with+HIV-infected+parents+in+southwest+China&rft.au=Yang%2C+H%3BWu%2C+Z.%3BDuan%2C+S%3BLi%2C+Z.%3BLi%2C+X.%3BShen%2C+M%3BMathur%2C+A%3BStanton%2C+B&rft.aulast=Yang&rft.aufirst=H&rft.date=2006-10-01&rft.volume=18&rft.issue=7&rft.spage=647&rft.isbn=&rft.btitle=&rft.title=AIDS+care&rft.issn=09540121&rft_id=info:doi/10.1080%2F09540120500282896 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 6040 5676; 7480 12162 3898; 2212; 9184; 3754 3755; 5703 3617 6220; 11938 11949 13521; 93 116 30 DO - http://dx.doi.org/10.1080/09540120500282896 ER - TY - JOUR T1 - Familiality of Polarity at Illness Onset in Bipolar Affective Disorder AN - 220488925; 17012686 AB - Bipolar affective disorder is clinically heterogeneous, and clinical features that run in families may help define more homogeneous phenotypes. The authors sought to establish whether polarity at illness onset, which is related to severity and course, is a familial feature of bipolar affective disorder. The authors studied 971 subjects from 507 families ascertained through sibling pairs with bipolar I or schizoaffective bipolar disorder. Self-reported ages at onset of mania and major depression were used to code polarity at onset as manic, major depressive, or both (mania and major depression in the same onset year). Familial clustering was estimated by using mixed-effects regression analysis, and the relationship between polarity at onset and several other clinical features was assessed. As a preliminary test of genetic validity, the authors assessed the impact of polarity at onset on genetic linkage findings previously detected in this sample. Polarity at onset was significantly familial in this sample. This largely reflected relative pairs concordant for mania at onset, which occurred significantly more frequently than would be expected by chance. Mania at onset substantially increased the genetic linkage signal on chromosome 16p (maximum lod score=4.5) but had no effect on linkage to chromosome 6q. Mania at onset occurred at a later age on average than major depression at onset and was less likely to be complicated by panic attacks or alcoholism. Polarity at illness onset is a familial feature of bipolar affective disorder and is associated with important clinical indicators, which may help define more homogeneous subtypes of bipolar affective disorder. JF - The American Journal of Psychiatry AU - Kassem, Layla AU - Lopez, Victor AU - Hedeker, Don AU - Steele, Jo AU - et al Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1754 EP - 9 CY - Washington PB - American Psychiatric Association VL - 163 IS - 10 SN - 0002953X KW - Medical Sciences--Psychiatry And Neurology KW - Psychiatry KW - Bipolar disorder KW - Mental depression KW - Medical treatment KW - Severity of Illness Index KW - Genetic Linkage KW - Regression Analysis KW - Depressive Disorder, Major -- diagnosis KW - Age of Onset KW - Alcoholism -- diagnosis KW - Humans KW - Bipolar Disorder -- genetics KW - Depressive Disorder, Major -- epidemiology KW - Alcoholism -- genetics KW - Psychotic Disorders -- epidemiology KW - Depressive Disorder, Major -- genetics KW - Phenotype KW - Chromosomes, Human, Pair 6 -- genetics KW - Bipolar Disorder -- epidemiology KW - Lod Score KW - Psychotic Disorders -- genetics KW - Adult KW - Psychotic Disorders -- diagnosis KW - Siblings -- psychology KW - Cluster Analysis KW - Male KW - Female KW - Chromosomes, Human, Pair 16 -- genetics KW - Bipolar Disorder -- diagnosis KW - Family Health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/220488925?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthcompleteshell&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+Journal+of+Psychiatry&rft.atitle=Familiality+of+Polarity+at+Illness+Onset+in+Bipolar+Affective+Disorder&rft.au=Kassem%2C+Layla%3BLopez%2C+Victor%3BHedeker%2C+Don%3BSteele%2C+Jo%3Bet+al&rft.aulast=Kassem&rft.aufirst=Layla&rft.date=2006-10-01&rft.volume=163&rft.issue=10&rft.spage=1754&rft.isbn=&rft.btitle=&rft.title=The+American+Journal+of+Psychiatry&rft.issn=0002953X&rft_id=info:doi/ LA - English DB - ProQuest Central N1 - Copyright - Copyright American Psychiatric Association Oct 2006 N1 - Document feature - Graphs; References N1 - Last updated - 2013-02-08 N1 - CODEN - AJPSAO ER - TY - JOUR T1 - Efficient Design and Analysis of Biospecimens with Measurements Subject to Detection Limit AN - 21073782; 11132893 AB - Pooling biospecimens is a well accepted sampling strategy in biomedical research to reduce study cost of measuring biomarkers, and has been shown in the case of normally distributed data to yield more efficient estimation. In this paper we examine the efficiency of pooling, in the context of information matrix related to estimators of unknown parameters, when the biospecimens being pooled yield incomplete observations due to the instruments' limit of detection. Our investigation of three sampling strategies shows that, for a range of values of the detection limit, pooling is the most efficient sampling procedure. For certain other values of the detection limit, pooling can perform poorly. JF - Biometrical Journal AU - Vexler, Albert AU - Liu, Aiyi AU - Schisterman, Enrique F AD - Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, NIH/DHHS, 6100 Executive Blvd., Rockville, MD 20852, U.S.A, vexlera@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 780 EP - 791 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 5 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Sampling KW - biomarkers KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21073782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Efficient+Design+and+Analysis+of+Biospecimens+with+Measurements+Subject+to+Detection+Limit&rft.au=Vexler%2C+Albert%3BLiu%2C+Aiyi%3BSchisterman%2C+Enrique+F&rft.aulast=Vexler&rft.aufirst=Albert&rft.date=2006-10-01&rft.volume=48&rft.issue=5&rft.spage=780&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610266 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Sampling; Data processing; biomarkers DO - http://dx.doi.org/10.1002/bimj.200610266 ER - TY - JOUR T1 - Ultraviolet radiation, dietary vitamin D, and risk of non-Hodgkin lymphoma (United States) AN - 20726047; 7137219 AB - Objective: Because of conflicting findings about the relationship between ultraviolet (UV) radiation and the risk of non-Hodgkin lymphoma (NHL), we evaluated the risk of several indicators related to UV, including two not previously studied: dietary vitamin D, and ambient UV levels by residential location. Methods: As part of a case-control study conducted in four Surveillance, Epidemiology, and End Results (SEER) registries, we collected UV information from a self-administered questionnaire and computer-assisted personal interview with 551 NHL cases and 462 controls. We estimated the relative risk (RR) and 95% confidence intervals (CI) from unconditional logistic regression models. Results: Eye color, a marker of host susceptibility to UV, showed a decreasing risk gradient for lightest eyes (0.47) compared to darkest. Relative risks were in the range of 0.73-0.78 for participants reporting more hours in the mid-day summer sun. Use of sunlamps or tanning booths was associated with decreased risk (RR = 0.88), as was estimated overall ambient UV (RR = 0.76 per 50 RB-units) overall. Vitamin D intake from diet and supplements was not related to risk. Results were thus consistent for the various indicators, although some estimated risks were not statistically significant. Effects were generally similar for diffuse large B-cell (DLBCL) and follicular lymphomas. Conclusion: These data suggest a slight protective effect of sunlight against NHL, and they agree with geographic patterns of NHL incidence observed in the US. JF - Cancer Causes & Control AU - Hartge, Patricia AU - Lim, Unhee AU - Freedman, DMichal AU - Colt, Joanne S AU - Cerhan, James R AU - Cozen, Wendy AU - Severson, Richard K AU - Davis, Scott AD - National Cancer Institue, 6120 Executive Blvd. EPS/8090, Rockville, MD, 20852, USA, hartgep@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1045 EP - 1052 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 8 SN - 0957-5243, 0957-5243 KW - Risk Abstracts; Immunology Abstracts; Toxicology Abstracts KW - non-Hodgkin's lymphoma KW - Risk assessment KW - Eye KW - Statistical analysis KW - sun KW - Models KW - vitamins KW - U.V. radiation KW - Ultraviolet radiation KW - Sun KW - Regression analysis KW - Tanning KW - Sunlight KW - Lymphoma KW - Diets KW - Inventories KW - Data processing KW - Lymphocytes B KW - sunlight KW - Cancer KW - Color KW - USA KW - Vitamin D KW - Epidemiology KW - Dietary supplements KW - summer KW - lymphoma KW - X 24390:Radioactive Materials KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20726047?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Ultraviolet+radiation%2C+dietary+vitamin+D%2C+and+risk+of+non-Hodgkin+lymphoma+%28United+States%29&rft.au=Hartge%2C+Patricia%3BLim%2C+Unhee%3BFreedman%2C+DMichal%3BColt%2C+Joanne+S%3BCerhan%2C+James+R%3BCozen%2C+Wendy%3BSeverson%2C+Richard+K%3BDavis%2C+Scott&rft.aulast=Hartge&rft.aufirst=Patricia&rft.date=2006-10-01&rft.volume=17&rft.issue=8&rft.spage=1045&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-006-0040-8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Diets; Inventories; Data processing; Eye; Lymphocytes B; Statistical analysis; Color; Models; Vitamin D; U.V. radiation; Epidemiology; Dietary supplements; Sun; Regression analysis; Sunlight; Tanning; Lymphoma; non-Hodgkin's lymphoma; vitamins; Ultraviolet radiation; summer; sunlight; lymphoma; sun; Cancer; USA DO - http://dx.doi.org/10.1007/s10552-006-0040-8 ER - TY - JOUR T1 - Opposing Risks of Gastric Cardia and Noncardia Gastric Adenocarcinomas Associated With Helicobacter pylori Seropositivity AN - 20724585; 7124610 AB - BACKGROUND: Colonization with Helicobacter pylori is a risk factor for gastric adenocarcinoma, but the magnitude of this association and its relationship to anatomic location of the cancer, duration of follow-up, age at diagnosis, histologic subtype, and H. pylori strain differences are less clear. We conducted a prospective nested case-control study of H. pylori serology to address these questions. METHODS: Case and control subjects were selected from the 29 133 50- to 69-year-old males recruited into the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. At baseline, detailed demographic data and a serum sample were collected. From 1985 to 1999, 243 incident cases of gastric adenocarcinoma were diagnosed in cohort members. Serum samples from 234 case subjects (173 with noncardia gastric cancers and 61 with gastric cardia cancers) and 234 age-matched control subjects were assayed for antibodies against H. pylori whole-cell and CagA antigens. We fit conditional logistic regression models to estimate the unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association of H. pylori seropositivity, defined as seropositivity to either whole-cell or CagA antigens, with noncardia gastric and gastric cardia cancers. All statistical tests were two-sided. RESULTS: H. pylori seropositivity was strongly associated with the risk of noncardia gastric cancer (adjusted OR = 7.9, 95% CI = 3.0 to 20.9) but was inversely associated with the risk of gastric cardia cancer (adjusted OR = 0.31, 95% CI = 0.11 to 0.89). H. pylori seropositivity rates did not vary statistically significantly by length of follow-up, age at diagnosis, or histologic subtype. A calculation of rates showed that the absolute risks of noncardia gastric and cardia gastric adenocarcinomas in the H. pylori-positive participants of this cohort would be 63 and 12 per 100 000 person-years, respectively, whereas corresponding rates in H. pylori-negative participants would be 8 and 37 per 100 000 person-years, respectively. CONCLUSION: H. pylori is a strong risk factor for noncardia gastric cancer but is inversely associated with the risk of gastric cardia cancer. These findings bolster the hypothesis that decreasing H. pylori prevalence during the past century may have contributed to lower rates of noncardia cancer and higher rates of cardia cancer in Western countries. JF - Journal of the National Cancer Institute AU - Kamangar, Farin AU - Dawsey, Sanford M AU - Blaser, Martin J AU - Perez-Perez, Guillermo I AU - Pietinen, Pirjo AU - Newschaffer, Craig J AU - Abnet, Christian C AU - Albanes, Demetrius AU - Virtamo, Jarmo AU - Taylor, Philip R AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD (FK, SMD, CCA, DA, PRT) Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1445 EP - 1452 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 20 SN - 0027-8874, 0027-8874 KW - Microbiology Abstracts B: Bacteriology; Risk Abstracts KW - demography KW - Helicobacter pylori KW - Age KW - Statistical analysis KW - Serology KW - Cancer KW - colonization KW - Models KW - Demography KW - Colonization KW - Antibodies KW - Risk factors KW - prevention KW - Regression analysis KW - Gastric cancer KW - Adenocarcinoma KW - R2 23060:Medical and environmental health KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Opposing+Risks+of+Gastric+Cardia+and+Noncardia+Gastric+Adenocarcinomas+Associated+With+Helicobacter+pylori+Seropositivity&rft.au=Kamangar%2C+Farin%3BDawsey%2C+Sanford+M%3BBlaser%2C+Martin+J%3BPerez-Perez%2C+Guillermo+I%3BPietinen%2C+Pirjo%3BNewschaffer%2C+Craig+J%3BAbnet%2C+Christian+C%3BAlbanes%2C+Demetrius%3BVirtamo%2C+Jarmo%3BTaylor%2C+Philip+R&rft.aulast=Kamangar&rft.aufirst=Farin&rft.date=2006-10-01&rft.volume=98&rft.issue=20&rft.spage=1445&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Demography; Colonization; Antibodies; Risk factors; Regression analysis; Statistical analysis; Adenocarcinoma; Gastric cancer; Serology; Models; demography; Age; prevention; colonization; Cancer; Helicobacter pylori ER - TY - JOUR T1 - Comparative genomics of the lactic acid bacteria AN - 20723348; 7126328 AB - Lactic acid-producing bacteria are associated with various plant and animal niches and play a key role in the production of fermented foods and beverages. We report nine genome sequences representing the phylogenetic and functional diversity of these bacteria. The small genomes of lactic acid bacteria encode a broad repertoire of transporters for efficient carbon and nitrogen acquisition from the nutritionally rich environments they inhabit and reflect a limited range of biosynthetic capabilities that indicate both prototrophic and auxotrophic strains. Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats. JF - Proceedings of the National Academy of Sciences, USA AU - Makarova, K AU - Slesarev, A AU - Wolf, Y AU - Sorokin, A AU - Mirkin, B AU - Koonin, E AU - Pavlov, A AU - Pavlova, N AU - Karamychev, V AU - Polouchine, N AU - Shakhova, V AU - Grigoriev, I AU - Lou, Y AU - Rohksar, D AU - Lucas, S AU - Huang, K AU - Goodstein, D M AU - Hawkins, T AU - Plengvidhya, V AU - Welker, D AU - Hughes, J AU - Goh, Y AU - Benson, A AU - Baldwin, K AU - Lee, J-H AU - Diaz-Muniz, I AU - Dosti, B AU - Smeianov, V AU - Wechter, W AU - Barabote, R AU - Lorca, G AU - Altermann, E AU - Barrangou, R AU - Ganesan, B AU - Xie, Y AU - Rawsthorne, H AU - Tamir, D AU - Parker, C AU - Breidt, F AU - Broadbent, J AU - Hutkins, R AU - O'Sullivan, D AU - Steele, J AU - Unlu, G AU - Saier, M AU - Klaenhammer, T AU - Richardson, P AU - Kozyavkin, S AU - Weimer, B AU - Mills, D AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 15611 EP - 15616 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 42 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biotechnology and Bioengineering Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Phylogeny KW - Carbon KW - Beverages KW - Coevolution KW - Gene transfer KW - Niches KW - Fermented food KW - Lactic acid bacteria KW - genomics KW - Habitat KW - Nitrogen KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - W 30935:Food Biotechnology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723348?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Comparative+genomics+of+the+lactic+acid+bacteria&rft.au=Makarova%2C+K%3BSlesarev%2C+A%3BWolf%2C+Y%3BSorokin%2C+A%3BMirkin%2C+B%3BKoonin%2C+E%3BPavlov%2C+A%3BPavlova%2C+N%3BKaramychev%2C+V%3BPolouchine%2C+N%3BShakhova%2C+V%3BGrigoriev%2C+I%3BLou%2C+Y%3BRohksar%2C+D%3BLucas%2C+S%3BHuang%2C+K%3BGoodstein%2C+D+M%3BHawkins%2C+T%3BPlengvidhya%2C+V%3BWelker%2C+D%3BHughes%2C+J%3BGoh%2C+Y%3BBenson%2C+A%3BBaldwin%2C+K%3BLee%2C+J-H%3BDiaz-Muniz%2C+I%3BDosti%2C+B%3BSmeianov%2C+V%3BWechter%2C+W%3BBarabote%2C+R%3BLorca%2C+G%3BAltermann%2C+E%3BBarrangou%2C+R%3BGanesan%2C+B%3BXie%2C+Y%3BRawsthorne%2C+H%3BTamir%2C+D%3BParker%2C+C%3BBreidt%2C+F%3BBroadbent%2C+J%3BHutkins%2C+R%3BO%27Sullivan%2C+D%3BSteele%2C+J%3BUnlu%2C+G%3BSaier%2C+M%3BKlaenhammer%2C+T%3BRichardson%2C+P%3BKozyavkin%2C+S%3BWeimer%2C+B%3BMills%2C+D&rft.aulast=Makarova&rft.aufirst=K&rft.date=2006-10-01&rft.volume=103&rft.issue=42&rft.spage=15611&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phylogeny; Beverages; Carbon; Coevolution; Gene transfer; Fermented food; Niches; genomics; Lactic acid bacteria; Habitat; Nitrogen ER - TY - JOUR T1 - Enhancer Blocking by Chicken beta -Globin 5'-HS4: ROLE OF ENHANCER STRENGTH AND INSULATOR NUCLEOSOME DEPLETION AN - 20723170; 7123454 AB - The 5'-HS4 chicken beta -globin insulator functions as a positional enhancer blocker on chromatinized episomes in human cells, blocking the HS2 enhancer of the human beta -globin locus control region from activating a downstream epsilon -globin gene. 5'-HS4 interrupted formation of a domain of histone H3 and H4 acetylation encompassing the 6-kb minilocus and inhibited transfer of RNA polymerase from the enhancer to the gene promoter. We found that the enhancer blocking phenotype was amplified when the insulated locus contained a weakened HS2 enhancer in which clustered point mutations eliminated interaction of the transcription factor GATA-1. The GATA-1 mutation compromised recruitment of histone acetyltransferases and RNA polymerase II to HS2. Enhancer blocking correlated with a significant depletion of nucleosomes in the core region of the insulator as revealed by micrococcal nuclease and DNase I digestion studies. Nucleosome depletion at 5'-HS4 was dependent on interaction of the insulator protein CCCTC-binding factor (CTCF) and was required for enhancer blocking. These findings provide evidence that a domain of active chromatin is formed by spreading from an enhancer to a target gene and can be blocked by a nucleosome-free gap in an insulator. JF - Journal of Biological Chemistry AU - Zhao, Hui AU - Kim, AeRi AU - Song, Sang-hyun AU - Dean, Ann AD - Laboratory of Cellular and Developmental Biology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892 and the Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609-735 Korea Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 30573 EP - 30580 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 41 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Spreading KW - Chromatin KW - Histone acetyltransferase KW - Point mutation KW - Nuclease KW - Promoters KW - Acetylation KW - Enhancers KW - Nucleosomes KW - DNA-directed RNA polymerase KW - Transcription factors KW - Deoxyribonuclease KW - Histone H3 KW - J 02410:Animal Diseases KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723170?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Enhancer+Blocking+by+Chicken+beta+-Globin+5%27-HS4%3A+ROLE+OF+ENHANCER+STRENGTH+AND+INSULATOR+NUCLEOSOME+DEPLETION&rft.au=Zhao%2C+Hui%3BKim%2C+AeRi%3BSong%2C+Sang-hyun%3BDean%2C+Ann&rft.aulast=Zhao&rft.aufirst=Hui&rft.date=2006-10-01&rft.volume=281&rft.issue=41&rft.spage=30573&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Spreading; Chromatin; Histone acetyltransferase; Point mutation; Nuclease; Enhancers; Acetylation; Promoters; DNA-directed RNA polymerase; Nucleosomes; Transcription factors; Deoxyribonuclease; Histone H3 ER - TY - JOUR T1 - Time to clearance of human papillomavirus infection by type and human immunodeficiency virus serostatus AN - 20654097; 8079114 AB - Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance of HPV infections in 522 HIV-seropositive and 279 HIV-seronegative participants in the HIV Epidemiology Research Study (HERS, United States, 1993-2000). Type-specific HPV infections were detected using MY09/MY11/HMB01-based PCR and 26 HPV type-specific probes. The estimated duration of type-specific infections was measured from the first HPV-positive visit to the first of two consecutive negative visits. Hazard ratios (HRs) and 95% confidence intervals (CIs) for HPV clearance were calculated using Cox models adjusted for study site and risk behavior (sexual or injection drugs). A total of 1,800 HPV infections were detected in 801 women with 4.4 years median follow-up. HRs for clearance of HPV16 and related types versus low-risk HPV types were 0.79 (95% CI: 0.64-0.97) in HIV-positive women and 0.86 (95% CI: 0.59-1.27) in HIV-negative women. HRs for HPV18 versus low-risk types were 0.80 (95% CI: 0.56-1.16) and 0.57 (95% CI: 0.22-1.45) for HIV-positive and -negative women, respectively. HPV types within the high-risk category had low estimated clearance rates relative to low-risk types, but HRs were not substantially modified by HIV serostatus. JF - International Journal of Cancer AU - Koshiol, Jill E AU - Schroeder, Jane C AU - Jamieson, Denise J AU - Marshall, Stephen W AU - Duerr, Ann AU - Heilig, Charles M AU - Shah, Keerti V AU - Klein, Robert S AU - Cu-Uvin, Susan AU - Schuman, Paula AU - Celentano, David AU - Smith, Jennifer S AD - Department of Epidemiology, University of North Carolina, Chapel Hill, NC, koshiolj@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1623 EP - 1629 PB - John Wiley & Sons, 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 7 SN - 0020-7136, 0020-7136 KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Risk Abstracts KW - HER protein KW - Probes KW - Human papillomavirus 18 KW - Drug abuse KW - Sexual behavior KW - Cancer KW - Persistent infection KW - Models KW - USA KW - Epidemiology KW - Human immunodeficiency virus KW - Human papillomavirus 16 KW - Risk factors KW - Carcinogenesis KW - infection KW - Risk groups KW - Polymerase chain reaction KW - Cervix KW - Drugs KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20654097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Time+to+clearance+of+human+papillomavirus+infection+by+type+and+human+immunodeficiency+virus+serostatus&rft.au=Koshiol%2C+Jill+E%3BSchroeder%2C+Jane+C%3BJamieson%2C+Denise+J%3BMarshall%2C+Stephen+W%3BDuerr%2C+Ann%3BHeilig%2C+Charles+M%3BShah%2C+Keerti+V%3BKlein%2C+Robert+S%3BCu-Uvin%2C+Susan%3BSchuman%2C+Paula%3BCelentano%2C+David%3BSmith%2C+Jennifer+S&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2006-10-01&rft.volume=119&rft.issue=7&rft.spage=1623&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - HER protein; Epidemiology; Risk factors; Carcinogenesis; Probes; Polymerase chain reaction; Risk groups; Cervix; Drugs; Sexual behavior; Persistent infection; Models; infection; Drug abuse; Cancer; Human immunodeficiency virus; Human papillomavirus 16; Human papillomavirus 18; Human papillomavirus; USA DO - http://dx.doi.org/10.1002/ijc.22015 ER - TY - JOUR T1 - Timeline: The NCI60 human tumour cell line anticancer drug screen AN - 20523737; 7116031 AB - The US National Cancer Institute (NCI) 60 human tumour cell line anticancer drug screen (NCI60) was developed in the late 1980s as an in vitro drug- discovery tool intended to supplant the use of transplantable animal tumours in anticancer drug screening. This screening model was rapidly recognized as a rich source of information about the mechanisms of growth inhibition and tumour-cell kill. Recently, its role has changed to that of a service screen supporting the cancer research community. Here I review the development, use and productivity of the screen, highlighting several outcomes that have contributed to advances in cancer chemotherapy. JF - Nature Reviews: Cancer AU - Shoemaker, Robert H AD - Robert H. Shoemaker is at the Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland 21702-1201, USA., shoemaker@dtpax2.ncifcrf.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 813 EP - 823 PB - Nature Publishing Group, Brunel Road Houndmills Basingstoke Hampshire RG21 6XS UK, [URL:http://www.naturesj.com/sj/index.html] VL - 6 IS - 10 SN - 1474-175X, 1474-175X KW - Biotechnology and Bioengineering Abstracts; Oncogenes & Growth Factors Abstracts KW - Tumor cell lines KW - Chemotherapy KW - Reviews KW - Drug screening KW - Cancer KW - B 26690:General, Reviews, Book Notices KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20523737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Timeline%3A+The+NCI60+human+tumour+cell+line+anticancer+drug+screen&rft.au=Shoemaker%2C+Robert+H&rft.aulast=Shoemaker&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=6&rft.issue=10&rft.spage=813&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc1951 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Reviews; Tumor cell lines; Chemotherapy; Drug screening DO - http://dx.doi.org/10.1038/nrc1951 ER - TY - JOUR T1 - Topoisomerase I inhibitors: camptothecins and beyond AN - 20279036; 7116034 AB - Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only known target of the alkaloid camptothecin, from which the potent anticancer agents irinotecan and topotecan are derived. As camptothecins bind at the interface of the TOP1-DNA complex, they represent a paradigm for interfacial inhibitors that reversibly trap macromolecular complexes. Several camptothecin and non-camptothecin derivatives are being developed to further increase anti- tumour activity and reduce side effects. The mechanisms and molecular determinants of tumour response to TOP1 inhibitors are reviewed, and rational combinations of TOP1 inhibitors with other drugs are considered based on current knowledge of repair and checkpoint pathways that are associated with TOP1- mediated DNA damage. JF - Nature Reviews: Cancer AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892-4255, USA., pommier@nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 789 EP - 802 PB - Nature Publishing Group, Brunel Road Houndmills Basingstoke Hampshire RG21 6XS UK, [URL:http://www.naturesj.com/sj/index.html] VL - 6 IS - 10 SN - 1474-175X, 1474-175X KW - Oncogenes & Growth Factors Abstracts; Biotechnology and Bioengineering Abstracts KW - Macromolecules KW - Irinotecan KW - DNA topoisomerase KW - Enzymes KW - Antitumor agents KW - Camptothecin KW - DNA damage KW - Alkaloids KW - Reviews KW - Topotecan KW - Drugs KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines KW - B 26640:Cell Cycle & DNA Repair UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20279036?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Cancer&rft.atitle=Topoisomerase+I+inhibitors%3A+camptothecins+and+beyond&rft.au=Pommier%2C+Yves&rft.aulast=Pommier&rft.aufirst=Yves&rft.date=2006-10-01&rft.volume=6&rft.issue=10&rft.spage=789&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Cancer&rft.issn=1474175X&rft_id=info:doi/10.1038%2Fnrc1977 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA damage; Macromolecules; Alkaloids; Reviews; Irinotecan; DNA topoisomerase; Enzymes; Topotecan; Drugs; Antitumor agents; Side effects; Camptothecin DO - http://dx.doi.org/10.1038/nrc1977 ER - TY - JOUR T1 - A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro AN - 20247606; 7063352 AB - A zebrafish transcript dubbed GA2692 was initially identified via a whole-mount in situ hybridization screen for vessel specific transcripts. Its mRNA expression during embryonic development was detected in ventral hematopoietic and vasculogenic mesoderm and later throughout the vasculature up to 48 hours post fertilization. Morpholino-mediated knockdown of GA2692 in embryos resulted in multiple defects in vasculature, particularly, at sites undergoing active capillary sprouting: the intersegmental vessels, sub-intestinal vessels and the capillary sprouts of the pectoral fin vessel. During the course of these studies, a homology search indicated that GA2692 is the zebrafish orthologue of mammalian HspA12B, a distant member of the heat shock protein 70 (Hsp70) family. By a combination of northern blot and real-time PCR analysis, we showed that HspA12B is highly expressed in human endothelial cells in vitro. Knockdown of HspA12B by small interfering RNAs (siRNAs) in human umbilical vein endothelial cells blocked wound healing, migration and tube formation, whereas overexpression of HspA12B enhanced migration and accelerated wound healing - data that are consistent with the in vivo fish phenotype obtained in the morpholino-knockdown studies. Phosphorylation of Akt was consistently reduced by siRNAs against HspA12B. Overexpression of a constitutively active form of Akt rescued the inhibitory effects of knockdown of HspA12B on migration of human umbilical vein endothelial cells. Collectively, our data suggests that HspA12B is a highly endothelial-cell-specific distant member of the Hsp70 family and plays a significant role in endothelial cells during development and angiogenesis in vitro, partially attributable to modulation of Akt phosphorylation. JF - Journal of Cell Science AU - Hu, Guang AU - Tang, Jian AU - Zhang, Bo AU - Lin, Yanfeng AU - Hanai, Jun-ichi AU - Galloway, Jenna AU - Bedell, Victoria AU - Bahary, Nathan AU - Han, Zhihua AU - Ramchandran, Ramani AU - Thisse, Bernard AU - Thisse, Christine AU - Zon, Leonard I AU - Sukhatme, Vikas P AD - Renal Division, Center for Study of the Tumor Microenvironment and Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Division of Hematology/Oncology, Children's Hospital, Department of Medicine, Boston, MA 02215, USA. National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA. Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, W1257 BSTWR, Pittsburgh, PA 15261, USA. Department of Biochemistry and Molecular Biology, East Tennessee State University, Johnson City, TN 37614, USA. Institut de Biologie Moleculaire et Cellulaire, CNRS, INSERM, Universite Louis Pasteur, C. U. de Strasbourg, France Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 4117 EP - 4126 PB - Company of Biologists, 140 Cowley Road Cambridge CB4 0DL UK VL - 119 IS - 19 SN - 0021-9533, 0021-9533 KW - Zebra danio KW - Biotechnology and Bioengineering Abstracts; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts KW - Heat shock proteins KW - Nucleotide sequence KW - Angiogenesis KW - Development KW - Freshwater KW - umbilical vein KW - Freshwater fish KW - Phenotypes KW - Gene expression KW - Endothelial cells KW - Fertilization KW - Phosphorylation KW - Hsp70 protein KW - Blood vessels KW - AKT protein KW - Polymerase chain reaction KW - Heat shock KW - Embryos KW - Cell migration KW - Circulatory system KW - Data processing KW - Embryonic development KW - Transcription KW - Wound healing KW - Mesoderm KW - Danio rerio KW - Embryogenesis KW - siRNA KW - Homology KW - Fish physiology KW - DNA KW - Hemopoiesis KW - Q1 08346:Physiology, biochemistry, biophysics KW - G 07730:Development & Cell Cycle KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=A+novel+endothelial-specific+heat+shock+protein+HspA12B+is+required+in+both+zebrafish+development+and+endothelial+functions+in+vitro&rft.au=Hu%2C+Guang%3BTang%2C+Jian%3BZhang%2C+Bo%3BLin%2C+Yanfeng%3BHanai%2C+Jun-ichi%3BGalloway%2C+Jenna%3BBedell%2C+Victoria%3BBahary%2C+Nathan%3BHan%2C+Zhihua%3BRamchandran%2C+Ramani%3BThisse%2C+Bernard%3BThisse%2C+Christine%3BZon%2C+Leonard+I%3BSukhatme%2C+Vikas+P&rft.aulast=Hu&rft.aufirst=Guang&rft.date=2006-10-01&rft.volume=119&rft.issue=19&rft.spage=4117&rft.isbn=&rft.btitle=&rft.title=Journal+of+Cell+Science&rft.issn=00219533&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Blood vessels; Fish physiology; Nucleotide sequence; DNA; Embryonic development; Heat shock; Freshwater fish; Phenotypes; Circulatory system; Heat shock proteins; Data processing; Angiogenesis; Wound healing; Transcription; Development; umbilical vein; Mesoderm; Endothelial cells; Gene expression; Fertilization; Embryogenesis; Homology; siRNA; Hsp70 protein; Phosphorylation; AKT protein; Hemopoiesis; Polymerase chain reaction; Embryos; Cell migration; Danio rerio; Freshwater ER - TY - JOUR T1 - Compartmentalized Intrapulmonary Pharmacokinetics of Amphotericin B and Its Lipid Formulations AN - 20000543; 7119287 AB - We investigated the compartmentalized intrapulmonary pharmacokinetics of amphotericin B and its lipid formulations in healthy rabbits. Cohorts of three to seven noninfected, catheterized rabbits received 1 mg of amphotericin B deoxycholate (DAMB) per kg of body weight or 5 mg of either amphotericin B colloidal dispersion (ABCD), amphotericin B lipid complex (ABLC), or liposomal amphotericin B (LAMB) per kg once daily for a total of 8 days. Following sparse serial plasma sampling, rabbits were sacrificed 24 h after the last dose, and epithelial lining fluid (ELF), pulmonary alveolar macrophages (PAM), and lung tissue were obtained. Pharmacokinetic parameters in plasma were derived by model-independent techniques, and concentrations in ELF and PAM were calculated based on the urea dilution method and macrophage cell volume, respectively. Mean amphotericin B concentrations plus or minus standard deviations (SD) in lung tissue and PAM were highest in ABLC-treated animals, exceeding concurrent plasma levels by 70- and 375-fold, respectively (in lung tissue, 16.24 plus or minus 1.62 versus 2.71 plus or minus 1.22, 6.29 plus or minus 1.17, and 6.32 plus or minus 0.57 mu g/g for DAMB-, ABCD-, and LAMB-treated animals, respectively [P = 0.0029]; in PAM, 89.1 plus or minus 37.0 versus 8.92 plus or minus 2.89, 5.43 plus or minus 1.75, and 7.52 plus or minus 2.50 mu g/ml for DAMB-, ABCD-, and LAMB-treated animals, respectively [P = 0.0246]). By comparison, drug concentrations in ELF were much lower than those achieved in lung tissue and PAM. Among the different cohorts, the highest ELF concentrations were found in LAMB-treated animals (2.28 plus or minus 1.43 versus 0.44 plus or minus 0.13, 0.68 plus or minus 0.27, and 0.90 plus or minus 0.28 mu g/ml in DAMB-, ABCD-, and ABLC-treated animals, respectively [P = 0.0070]). In conclusion, amphotericin B and its lipid formulations displayed strikingly different patterns of disposition in lungs 24 h after dosing. Whereas the disposition of ABCD was overall not fundamentally different from that of DAMB, ABLC showed prominent accumulation in lung tissue and PAM, while LAMB achieved the highest concentrations in ELF. JF - Antimicrobial Agents & Chemotherapy AU - Groll, Andreas H AU - Lyman, Caron A AU - Petraitis, Vidmantas AU - Petraitiene, Ruta AU - Armstrong, Derek AU - Mickiene, Diana AU - Alfaro, Raul M AU - Schaufele, Robert L AU - Sein, Tin AU - Bacher, John AU - Walsh, Thomas J AD - Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland. Pharmacokinetics Research Laboratory, Pharmacy Department, Warren Grant Magnuson Clinical Center, Bethesda, Maryland. Division of Veterinary Resources, National Institutes of Health, Bethesda, Maryland. Infectious Disease Research Program, Center for Bone Marrow Transplantation and Department of Pediatric Hematology/Oncology, University Children's Hospital, Muenster, Germany Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 3418 EP - 3423 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Macrophages KW - Amphotericin B KW - Lipids KW - Urea KW - Disposition KW - Alveoli KW - Pharmacokinetics KW - Plasma levels KW - Standard deviation KW - Body weight KW - Lung KW - Cell size KW - Sampling KW - Drugs KW - A 01340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20000543?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Compartmentalized+Intrapulmonary+Pharmacokinetics+of+Amphotericin+B+and+Its+Lipid+Formulations&rft.au=Groll%2C+Andreas+H%3BLyman%2C+Caron+A%3BPetraitis%2C+Vidmantas%3BPetraitiene%2C+Ruta%3BArmstrong%2C+Derek%3BMickiene%2C+Diana%3BAlfaro%2C+Raul+M%3BSchaufele%2C+Robert+L%3BSein%2C+Tin%3BBacher%2C+John%3BWalsh%2C+Thomas+J&rft.aulast=Groll&rft.aufirst=Andreas&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=3418&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-06-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Macrophages; Amphotericin B; Lipids; Disposition; Urea; Pharmacokinetics; Alveoli; Plasma levels; Standard deviation; Body weight; Lung; Cell size; Sampling; Drugs ER - TY - JOUR T1 - Development of a Human Immunodeficiency Virus Vector-Based, Single-Cycle Assay for Evaluation of Anti-Integrase Compounds AN - 20000274; 7119286 AB - Therapeutic strategies aimed at inhibiting human immunodeficiency virus type 1 (HIV-1) replication employ a combination of drugs targeted to two viral enzymes (reverse transcriptase and protease) and to the viral entry/fusion step. However, the high propensity of HIV-1 to develop resistance makes the development of novel compounds targeting different steps of the HIV-1 life cycle essential. Among these, integrase (IN) inhibitors have successfully passed the early phases of clinical development. By preventing integration, IN inhibitors preclude viral replication while allowing production of extrachromosomal forms of viral DNA (E-DNA). Here, we describe an improved and standardized assay aimed at evaluating IN inhibitors by taking advantage of the transcriptional activity of E-DNA produced by HIV-derived vectors in the absence of replication-competent virus. In this context, the use of the firefly luciferase gene as a reporter gene provides a rapid and quantitative measure of viral-vector infectivity, thus making it a safe and cost-effective assay for evaluating novel IN inhibitors. JF - Antimicrobial Agents & Chemotherapy AU - Bona, Roberta AU - Andreotti, Mauro AU - Buffa, Viviana AU - Leone, Pasqualina AU - Galluzzo, Clementina Maria AU - Amici, Roberta AU - Palmisano, Lucia AU - Mancini, Maria Grazia AU - Michelini, Zuleika AU - Di Santo, Roberto AU - Costi, Roberta AU - Roux, Alessandra AU - Pommier, Yves AU - Marchand, Christophe AU - Vella, Stefano AU - Cara, Andrea AD - National AIDS Center. Department of Drug Research and Evaluation, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy. Istituto Pasteur-Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, P.le Aldo Moro 5, 00185 Rome, Italy. Laboratory of Molecular Pharmacology, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 3407 EP - 3417 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 10 SN - 0066-4804, 0066-4804 KW - HIV-1 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts KW - Replication KW - Life cycle KW - Transcription KW - Enzymes KW - Antimicrobial agents KW - Integration KW - Infectivity KW - Reporter gene KW - Human immunodeficiency virus 1 KW - DNA KW - RNA-directed DNA polymerase KW - Proteinase KW - Integrase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20000274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Development+of+a+Human+Immunodeficiency+Virus+Vector-Based%2C+Single-Cycle+Assay+for+Evaluation+of+Anti-Integrase+Compounds&rft.au=Bona%2C+Roberta%3BAndreotti%2C+Mauro%3BBuffa%2C+Viviana%3BLeone%2C+Pasqualina%3BGalluzzo%2C+Clementina+Maria%3BAmici%2C+Roberta%3BPalmisano%2C+Lucia%3BMancini%2C+Maria+Grazia%3BMichelini%2C+Zuleika%3BDi+Santo%2C+Roberto%3BCosti%2C+Roberta%3BRoux%2C+Alessandra%3BPommier%2C+Yves%3BMarchand%2C+Christophe%3BVella%2C+Stefano%3BCara%2C+Andrea&rft.aulast=Bona&rft.aufirst=Roberta&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=3407&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Integration; Infectivity; Reporter gene; Replication; DNA; RNA-directed DNA polymerase; Enzymes; Transcription; Life cycle; Proteinase; Integrase; Antimicrobial agents; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Cellular telephones and non-Hodgkin lymphoma AN - 19996091; 7074579 AB - Dramatic increase in hand-held cellular telephone use since the 1980s and excess risk of lymphoproliferative malignancies associated with radio-frequency radiation (RFR) exposures in epidemiological and experimental studies motivated assessment of cellular telephones within a comprehensive US case-control investigation of non-Hodgkin lymphoma (NHL). A questionnaire ascertained cellular telephone use in 551 NHL cases and 462 frequency-matched population controls. Compared to persons who had never used cellular telephones, risks were not increased among individuals whose lifetime use was fewer than 10 (odds ratio (OR) = 0.9, 95% confidence intervals (CI): 0.6, 1.3), 10-100 (OR = 1.0, 95 % CI: 0.7, 1.5) or more than 100 times (e.g., regular users, OR = 0.9, 95% CI: 0.6, 1.4). Among regular users compared to those who had never used hand-held cellular telephones, risks of NHL were not significantly associated with minutes per week, duration, cumulative lifetime or year of first use, although NHL was non-significantly higher in men who used cellular telephones for more than 8 years. Little evidence linked use of cellular telephones with total, diffuse large B-cell lymphoma or follicular NHL. These findings must be interpreted in the context of less than 5% of the population reporting duration of use of 6 or more years or lifetime cumulative use of 200 or more hours. JF - International Journal of Cancer AU - Linet, Martha S AU - Taggart, Theresa AU - Severson, Richard K AU - Cerhan, James R AU - Cozen, Wendy AU - Hartge, Patricia AU - Colt, Joanne AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MA, linetm@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2382 EP - 2388 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 10 SN - 0020-7136, 0020-7136 KW - Non-Hodgkin's lymphoma KW - Immunology Abstracts; Risk Abstracts; Toxicology Abstracts; Health & Safety Science Abstracts KW - lymphoma KW - non-Hodgkin KW - hand-held cellular telephone KW - radiofrequency/microwave radiation KW - case-control study KW - epidemiology KW - Inventories KW - cellular telephones KW - Malignancy KW - double prime B-cell lymphoma KW - Radiation KW - Cellular telephones KW - Lymphocytes KW - Cancer KW - X 24390:Radioactive Materials KW - H 8000:Radiation Safety/Electrical Safety KW - R2 23020:Technological risks KW - F 06915:Cancer Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19996091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Cellular+telephones+and+non-Hodgkin+lymphoma&rft.au=Linet%2C+Martha+S%3BTaggart%2C+Theresa%3BSeverson%2C+Richard+K%3BCerhan%2C+James+R%3BCozen%2C+Wendy%3BHartge%2C+Patricia%3BColt%2C+Joanne&rft.aulast=Linet&rft.aufirst=Martha&rft.date=2006-10-01&rft.volume=119&rft.issue=10&rft.spage=2382&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22151 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Malignancy; double prime B-cell lymphoma; Radiation; Cellular telephones; Lymphocytes; cellular telephones; lymphoma; Cancer DO - http://dx.doi.org/10.1002/ijc.22151 ER - TY - JOUR T1 - Enhanced Antiscrapie Effect Using Combination Drug Treatment AN - 19984331; 7119291 AB - Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases. JF - Antimicrobial Agents & Chemotherapy AU - Kocisko, David A AU - Caughey, Byron AU - Morrey, John D AU - Race, Richard E AD - Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana. Institute for Antiviral Research, Animal, Dairy, and Veterinary Sciences Department, Utah State University, Logan, Utah Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 3447 EP - 3449 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 10 SN - 0066-4804, 0066-4804 KW - Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Transmissible spongiform encephalopathy KW - Inoculation KW - Survival KW - Scrapie KW - pentosan polysulfate KW - Drugs KW - Antimicrobial agents KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19984331?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Enhanced+Antiscrapie+Effect+Using+Combination+Drug+Treatment&rft.au=Kocisko%2C+David+A%3BCaughey%2C+Byron%3BMorrey%2C+John+D%3BRace%2C+Richard+E&rft.aulast=Kocisko&rft.aufirst=David&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=3447&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transmissible spongiform encephalopathy; Inoculation; Survival; Scrapie; pentosan polysulfate; Drugs; Antimicrobial agents ER - TY - JOUR T1 - Neural Stem Cell Model for Prion Propagation AN - 19978777; 7126858 AB - The study of prion transmission and targeting is a major scientific issue with important consequences for public health. Only a few cell culture systems that are able to convert the cellular isoform of the prion protein into the pathologic scrapie isoform of the prion protein (PrP super(Sc)) have been described. We hypothesized that central nervous system neural stem cells (NSCs) could be the basis of a new cell culture model permissive to prion infection. Here, we report that monolayers of differentiated fetal NSCs and adult multipotent progenitor cells isolated from mice were able to propagate prions. We also demonstrated the large influence of neural cell fate on the production of PrP super(Sc), allowing the molecular study of prion neuronal targeting in relation with strain differences. This new stem cell-based model, which is applicable to different species and to transgenic mice, will allow thoughtful investigations of the molecular basis of prion diseases, and will open new avenues for diagnostic and therapeutic research. JF - Stem Cells AU - Milhavet, Ollivier AU - Casanova, Danielle AU - Chevallier, Nathalie AU - McKay, Ronald DG AU - Lehmann, Sylvain AD - Institut de Genetique Humaine, CNRS-UPR1142, Montpellier, France. Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, Maryland, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2284 EP - 2291 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 10 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Molecular modelling KW - Central nervous system KW - Animal models KW - Cell culture KW - Scrapie KW - Infection KW - Transgenic mice KW - Fetuses KW - Public health KW - Stem cells KW - Neurotransmission KW - Prion protein KW - Cell fate KW - Neural stem cells KW - W 30945:Fermentation & Cell Culture KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19978777?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Neural+Stem+Cell+Model+for+Prion+Propagation&rft.au=Milhavet%2C+Ollivier%3BCasanova%2C+Danielle%3BChevallier%2C+Nathalie%3BMcKay%2C+Ronald+DG%3BLehmann%2C+Sylvain&rft.aulast=Milhavet&rft.aufirst=Ollivier&rft.date=2006-10-01&rft.volume=24&rft.issue=10&rft.spage=2284&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Central nervous system; Molecular modelling; Animal models; Cell culture; Scrapie; Transgenic mice; Infection; Fetuses; Public health; Stem cells; Neurotransmission; Prion protein; Cell fate; Neural stem cells ER - TY - JOUR T1 - TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia AN - 19976035; 7126249 AB - Acute lymphoblastic leukemia (ALL) is a clonal disease that evolves through the accrual of genetic rearrangements and/or mutations within the dominant clone. The TEL-AML1 (ETV6-RUNX1) fusion in precursor-B (pre-B) ALL is the most common genetic rearrangement in childhood cancer; however, the cellular origin and the molecular pathogenesis of TEL-AML1-induced leukemia have not been identified. To study the origin of TEL-AML1-induced ALL, we generated transgenic zebrafish expressing TEL-AML1 either ubiquitously or in lymphoid progenitors. TEL-AML1 expression in all lineages, but not lymphoid-restricted expression, led to progenitor cell expansion that evolved into oligoclonal B-lineage ALL in 3% of the transgenic zebrafish. This leukemia was transplantable to conditioned wild-type recipients. We demonstrate that TEL-AML1 induces a B cell differentiation arrest, and that leukemia development is associated with loss of TEL expression and elevated Bcl2/Bax ratio. The TEL-AML1 transgenic zebrafish models human pre-B ALL, identifies the molecular pathways associated with leukemia development, and serves as the foundation for subsequent genetic screens to identify modifiers and leukemia therapeutic targets. JF - Proceedings of the National Academy of Sciences, USA AU - Sabaawy, Hatem E AU - Azuma, Mizuki AU - Embree, Lisa J AU - Tsai, Huai-Jen AU - Starost, Matthew F AU - Hickstein, Dennis D AD - Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 Y1 - 2006/10// PY - 2006 DA - October 2006 SP - 15166 EP - 15171 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 41 SN - 0027-8424, 0027-8424 KW - Zebra danio KW - Zebra fish KW - Immunology Abstracts; Biotechnology and Bioengineering Abstracts; ASFA 1: Biological Sciences & Living Resources; Genetics Abstracts; ASFA Marine Biotechnology Abstracts KW - Clones KW - Molecular modelling KW - Lymphocytes B KW - Mutations KW - Animal models KW - Freshwater KW - Children KW - Freshwater fish KW - Cancer KW - Danio rerio KW - Differentiation KW - Stem cells KW - Acute lymphatic leukemia KW - Bax protein KW - Genetic screening KW - Cell differentiation KW - Mutation KW - Modelling KW - W 30925:Genetic Engineering KW - Q1 08484:Species interactions: parasites and diseases KW - Q4 27790:Fish KW - G 07840:Fish KW - F 06940:Fish Immunity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19976035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=TEL-AML1+transgenic+zebrafish+model+of+precursor+B+cell+acute+lymphoblastic+leukemia&rft.au=Sabaawy%2C+Hatem+E%3BAzuma%2C+Mizuki%3BEmbree%2C+Lisa+J%3BTsai%2C+Huai-Jen%3BStarost%2C+Matthew+F%3BHickstein%2C+Dennis+D&rft.aulast=Sabaawy&rft.aufirst=Hatem&rft.date=2006-10-01&rft.volume=103&rft.issue=41&rft.spage=15166&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Clones; Mutations; Cell differentiation; Freshwater fish; Modelling; Differentiation; Molecular modelling; Stem cells; Lymphocytes B; Bax protein; Acute lymphatic leukemia; Animal models; Genetic screening; Children; Mutation; Cancer; Danio rerio; Freshwater ER - TY - JOUR T1 - Mycobacterium leprae Is Naturally Resistant to PA-824 AN - 19972723; 7119278 AB - Leprosy responds very slowly to the current multidrug therapy, and hence there is a need for novel drugs with potent bactericidal activity. PA-824 is a 4-nitroimidazo-oxazine that is currently undergoing phase I clinical trials for the treatment of tuberculosis. The activity of PA-824 against Mycobacterium leprae was tested and compared with that of rifampin in axenic cultures, macrophages, and two different animal models. Our results conclusively demonstrate that PA-824 has no effect on the viability of M. leprae in all three models, consistent with the lack of the nitroimidazo-oxazine-specific nitroreductase, encoded by Rv3547 in the M. leprae genome, which is essential for activation of this molecule. JF - Antimicrobial Agents & Chemotherapy AU - Manjunatha, Ujjini H AU - Lahiri, Ramanuj AU - Randhawa, Baljit AU - Dowd, Cynthia S AU - Krahenbuhl, James L AU - Barry, Clifton EIII AD - Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, 12441 Parklawn Drive, Twinbrook II, Rockville, Maryland. Laboratory Research Branch, National Hansen's Disease Programs, Louisiana State University, Skip Bertman Drive, Baton Rouge, Louisiana 70803 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 3350 EP - 3354 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 10 SN - 0066-4804, 0066-4804 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Genomes KW - Pure culture KW - Molecular modelling KW - Mycobacterium KW - Mycobacterium leprae KW - Animal models KW - Clinical trials KW - Antimicrobial agents KW - Leprosy KW - Nitroreductase KW - Rifampin KW - Tuberculosis KW - Drugs KW - Bactericidal activity KW - A 01340:Antibiotics & Antimicrobials KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19972723?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Mycobacterium+leprae+Is+Naturally+Resistant+to+PA-824&rft.au=Manjunatha%2C+Ujjini+H%3BLahiri%2C+Ramanuj%3BRandhawa%2C+Baljit%3BDowd%2C+Cynthia+S%3BKrahenbuhl%2C+James+L%3BBarry%2C+Clifton+EIII&rft.aulast=Manjunatha&rft.aufirst=Ujjini&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=3350&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Pure culture; Genomes; Macrophages; Molecular modelling; Animal models; Clinical trials; Leprosy; Antimicrobial agents; Nitroreductase; Rifampin; Tuberculosis; Bactericidal activity; Drugs; Mycobacterium; Mycobacterium leprae ER - TY - JOUR T1 - Engineered Vaginal Lactobacillus Strain for Mucosal Delivery of the Human Immunodeficiency Virus Inhibitor Cyanovirin-N AN - 19968835; 7119264 AB - Women are at significant risk of human immunodeficiency virus (HIV) infection, with the cervicovaginal mucosa serving as a major portal for virus entry. Female-initiated preventatives, including topical microbicides, are urgently needed to help curtail the HIV/AIDS pandemic. Here we report on the development of a novel, live microbicide that employs a natural vaginal strain of Lactobacillus jensenii engineered to deliver the potent HIV inhibitor cyanovirin-N (CV-N). To facilitate efficient expression of CV-N by this bacterium, the L. jensenii 1153 genome was sequenced, allowing identification of native regulatory elements and sites for the chromosomal integration of heterologous genes. A CV-N expression cassette was optimized and shown to produce high levels of structurally intact CV-N when expressed in L. jensenii. Lactobacillus-derived CV-N was capable of inhibiting CCR5-tropic HIV sub(BaL) infectivity in vitro with a 50% inhibitory concentration of 0.3 nM. The CV-N expression cassette was stably integrated as a single copy into the bacterial chromosome and resolved from extraneous plasmid DNA without adversely affecting the bacterial phenotype. This bacterial strain was capable of colonizing the vagina and producing full-length CV-N when administered intravaginally to mice during estrus phase. The CV-N-producing Lactobacillus was genetically stable when propagated in vitro and in vivo. This work represents a major step towards the development of an inexpensive yet durable protein-based microbicide to block the heterosexual transmission of HIV in women. JF - Antimicrobial Agents & Chemotherapy AU - Liu, Xiaowen AU - Lagenaur, Laurel A AU - Simpson, David A AU - Essenmacher, Kirsten P AU - Frazier-Parker, Courtney L AU - Liu, Yang AU - Tsai, Daniel AU - Rao, Srinivas S AU - Hamer, Dean H AU - Parks, Thomas P AU - Lee, Peter P AU - Xu, Qiang AD - Osel, Inc., 4008 Burton Drive, Santa Clara, California 95054. Laboratory Animal Medicine, Vaccine Research Center, National Institutes of Health, Bethesda, Maryland 20892. Laboratory of Biochemistry, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892. Department of Medicine, Stanford University, Stanford, California 94305 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 3250 EP - 3259 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 10 SN - 0066-4804, 0066-4804 KW - HIV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts KW - Risk assessment KW - Genomes KW - Acquired immune deficiency syndrome KW - Regulatory sequences KW - Mucosa KW - Plasmids KW - Infection KW - Disease transmission KW - Antimicrobial agents KW - Integration KW - Chromosomes KW - Infectivity KW - cyanovirin-N KW - pandemics KW - Lactobacillus KW - Estrus KW - Human immunodeficiency virus KW - Vagina KW - DNA KW - microbicides KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - J 02400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19968835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Engineered+Vaginal+Lactobacillus+Strain+for+Mucosal+Delivery+of+the+Human+Immunodeficiency+Virus+Inhibitor+Cyanovirin-N&rft.au=Liu%2C+Xiaowen%3BLagenaur%2C+Laurel+A%3BSimpson%2C+David+A%3BEssenmacher%2C+Kirsten+P%3BFrazier-Parker%2C+Courtney+L%3BLiu%2C+Yang%3BTsai%2C+Daniel%3BRao%2C+Srinivas+S%3BHamer%2C+Dean+H%3BParks%2C+Thomas+P%3BLee%2C+Peter+P%3BXu%2C+Qiang&rft.aulast=Liu&rft.aufirst=Xiaowen&rft.date=2006-10-01&rft.volume=50&rft.issue=10&rft.spage=3250&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Risk assessment; Acquired immune deficiency syndrome; Regulatory sequences; Mucosa; Infection; Plasmids; Antimicrobial agents; Disease transmission; Integration; pandemics; cyanovirin-N; Infectivity; Chromosomes; Estrus; Vagina; DNA; microbicides; Lactobacillus; Human immunodeficiency virus ER - TY - JOUR T1 - t(14; 18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, Italy AN - 19965606; 7121286 AB - Dioxin exposure has been associated with non-Hodgkin's lymphoma (NHL) in epidemiological investigations. The NHL-related t(14; 18) translocations can be detected at a low copy number in lymphocytes from healthy subjects. Exposure to NHL-associated carcinogens, such as dioxin or pesticides, may cause expansion of t(14; 18)-positive clones. We investigated prevalence and frequency of circulating t(14; 18)-positive lymphocytes in 144 healthy subjects from a population exposed to dioxin [plasma TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) range: <1.7-475.0 parts per trillion (p.p.t.)] after the Seveso, Italy, accident of 1976. t(14; 18) translocations were measured in DNA from peripheral blood lymphocytes by high-sensitivity real-time quantitative polymerase chain reaction. We found that the frequency, but not the prevalence, of t(14; 18) translocation-positive cells increased with increasing plasma TCDD. Among t(14; 18)-positive subjects (n = 50; 34.7%), the mean number of t(14; 18) translocations/10 super(6) lymphocytes was 4.2 [95% confidence interval (CI), 2.9-6.2] in subjects with plasma TCDD < 10.0 p.p.t., 8.1 (95% CI, 4.9-13.3) in subjects with plasma TCDD between 10.0 and 50.0 and 12.5 (95% CI, 7.4-21.1) in subjects with plasma TCDD between 50.0 and 475.0 p.p.t. (P-trend = 0.003). As expected, t(14; 18) frequency was associated with cigarette smoking and was highest in subjects who smoked for greater than or equal to 16 years (mean = 12.6; 95% CI, 7.4-21.3; P = 0.01). Higher t(14; 18) prevalence was found among individuals with fair hair color (P = 0.01) and light eye color (P = 0.04). No significant association between t(14; 18)-and age was found. Our results show that dioxin exposure is associated with increased number of circulating t(14; 18) positive cells. Whether this change in t(14; 18) frequency is an indicator of elevated lymphoma risk remains speculative and needs further investigation for its potential impact on public health. JF - Carcinogenesis AU - Baccarelli, Andrea AU - Hirt, Carsten AU - Pesatori, Angela C AU - Consonni, Dario AU - Patterson, Donald GJr AU - Bertazzi, Pier Alberto AU - Doelken, Gottfried AU - Landi, Maria Teresa AD - EPOCA Research Center for Occupational, Clinical and Environmental Epidemiology, Department of Occupational and Environmental Health, University of Milan and IRCCS Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS Bethesda, MD, USA. Department of Hematology and Oncology, University Medical Center, Ernst-Moritz-Arndt-University Sauerbruchstrasse, D-17487 Greifswald, Germany. Division of Environmental Health Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention Atlanta, GA, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2001 EP - 2007 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 10 SN - 0143-3334, 0143-3334 KW - Immunology Abstracts; Toxicology Abstracts; Genetics Abstracts KW - Age KW - Eye KW - TCDD KW - Peripheral blood KW - Carcinogens KW - Lymphocytes KW - Hair KW - Light effects KW - Color KW - Public health KW - copy number KW - Non-Hodgkin's lymphoma KW - Accidents KW - Carcinogenesis KW - Cigarette smoking KW - Pesticides KW - Polymerase chain reaction KW - Lymphoma KW - Translocation KW - Dioxin KW - G 07710:Chemical Mutagenesis & Radiation KW - F 06915:Cancer Immunology KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19965606?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=t%2814%3B+18%29+translocations+in+lymphocytes+of+healthy+dioxin-exposed+individuals+from+Seveso%2C+Italy&rft.au=Baccarelli%2C+Andrea%3BHirt%2C+Carsten%3BPesatori%2C+Angela+C%3BConsonni%2C+Dario%3BPatterson%2C+Donald+GJr%3BBertazzi%2C+Pier+Alberto%3BDoelken%2C+Gottfried%3BLandi%2C+Maria+Teresa&rft.aulast=Baccarelli&rft.aufirst=Andrea&rft.date=2006-10-01&rft.volume=27&rft.issue=10&rft.spage=2001&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Eye; TCDD; Peripheral blood; Lymphocytes; Carcinogens; Hair; copy number; Public health; Color; Light effects; Non-Hodgkin's lymphoma; Accidents; Pesticides; Cigarette smoking; Carcinogenesis; Polymerase chain reaction; Translocation; Lymphoma; Dioxin ER - TY - JOUR T1 - The size distribution of polychlorinated dibenzo-p-dioxins and dibenzofurans in the bottom ash of municipal solid waste incinerators AN - 19867035; 7489198 AB - In this study, bottom ash was sampled from two Taiwanese municipal solid waste incinerators (MSWIs: A and B) and sieved to size classes of 4.75-9.5mm, 2.36-4.75mm, 1.0-2.36mm, 0.6-1.0mm, 0.3-0.6mm, 0.21-0.3mm, 0.125-0.21mm, 0.075-0.125mm and <0.074mm. For both MSWIs, the major peak in the particle size distribution for the PCDD/F content was found in a particle size <0.21mm, that is, 16.1 (A) and 4.37pg I-TEQ/g (B). This is due to the fact that a smaller particle has higher specific surface area thus offering more adsorption sites. The mean cumulative fractions (F%) of PCDD/F I-TEQ in the bottom ash of MSWI A and B in the particle size range below 0.6, 2.36 and 4.75mm, in sequence, are 40.4%, 77.2% and 95.6%, respectively. We suggest sieving the bottom ash before the subsequent reutilization at the suggested cut size of 0.6mm. In the view of PCDD/Fs, bottom ash with a particle size larger than 0.6mm, which is the more non-hazardous part, may be suitable for being the raw material of landfilling soil, road sub-base, and construction blocks. For the minus 0.6mm fraction, vitrification with fly ash is one of the choices. JF - Chemosphere AU - Chen, Che-Kuan AU - Lin, Chieh AU - Wang, Lin-Chi AU - Chang-Chien, Guo-Ping AD - Department of Environmental Engineering and Science, National Pingtung University of Science and Technology, Nei Pu 91207, Ping Tung, Taiwan, ROC, linchieh@mail.npust.edu.tw Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 514 EP - 520 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 65 IS - 3 SN - 0045-6535, 0045-6535 KW - Toxicology Abstracts; Pollution Abstracts KW - Dioxin KW - Municipal solid waste incinerators KW - Bottom ash KW - Particle size distribution KW - Particle size KW - Landfills KW - Surface area KW - Fly ash KW - Particulates KW - Municipal solid wastes KW - Solid wastes KW - Soil KW - Dibenzofuran KW - vitrification KW - Dibenzo-p-dioxin KW - Adsorption KW - raw materials KW - Incinerators KW - PCDD KW - Size distribution KW - surface area KW - X 24350:Industrial Chemicals KW - P 4000:WASTE MANAGEMENT UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19867035?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemosphere&rft.atitle=The+size+distribution+of+polychlorinated+dibenzo-p-dioxins+and+dibenzofurans+in+the+bottom+ash+of+municipal+solid+waste+incinerators&rft.au=Chen%2C+Che-Kuan%3BLin%2C+Chieh%3BWang%2C+Lin-Chi%3BChang-Chien%2C+Guo-Ping&rft.aulast=Chen&rft.aufirst=Che-Kuan&rft.date=2006-10-01&rft.volume=65&rft.issue=3&rft.spage=514&rft.isbn=&rft.btitle=&rft.title=Chemosphere&rft.issn=00456535&rft_id=info:doi/10.1016%2Fj.chemosphere.2006.01.021 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Soil; Particle size; Dibenzofuran; Surface area; vitrification; Adsorption; Dibenzo-p-dioxin; Fly ash; Incinerators; Size distribution; Solid wastes; Landfills; raw materials; Particulates; Municipal solid wastes; PCDD; surface area DO - http://dx.doi.org/10.1016/j.chemosphere.2006.01.021 ER - TY - JOUR T1 - Polymorphisms in Cytokine Genes and Risk of Helicobacter pylori Infection among Jamaican Children AN - 19854354; 7098442 AB - Background:Infection by Helicobacter pylori is often acquired during childhood. Recent studies suggest that inflammatory cytokines may play a role in susceptibility to, and disease phenotype caused by, H. pylori infection, but the association of host genetic variability with risk of H. pylori infection has not been studied in children. Methods:We investigated the relationship between the risk of H. pylori antibody positivity and cytokine gene polymorphisms among 199 two-year-old Jamaicans. H. pylori seropositivity was determined by a validated research enzyme-linked immunosorbent assay. Real-time Taqman registered polymerase chain reaction was used to determine variants at 17 loci in 11 cytokine genes (IL1A, IL1B, IL2, TNF, TLR4, IL4, IL6, IL10, IL10RA, IL12A and IL13). We estimated the odds ratio and the 95% confidence interval for the association of genetic polymorphisms with H. pylori seropositivity, using logistic regression. Results:Forty (20.1%) of 199 children were seropositive. Children's H. pylori seropositivity correlated highly with maternal H. pylori seropositivity (OR = 7.98, 95% CI = 1.05-60.60, p = .02). Children carrying IL1A-889T had a lower risk of H. pylori positivity, compared to those carrying -889C, with each T allele associated with 43% risk reduction (OR = 0.57, 95% CI = 0.33-0.99, p-trend = .05). No other loci we examined were associated with the risk of H. pylori seropositivity. Conclusions:The IL1A-889 T allele, known to express a higher level of cytokine IL-1 alpha , is associated with a lower risk of H. pylori infection among Jamaican children. Our finding supports the hypothesis that an upregulation of pro-inflammatory cytokines may protect against persistent H. pylori colonization. JF - Helicobacter AU - Tseng, Fan-Chen AU - Brown, Elizabeth E AU - Maiese, Eric M AU - Yeager, Meredith AU - Welch, Robert AU - Gold, Benjamin D AU - Owens, Marilyn AU - Cranston, Beverly AU - Hanchard, Barrie AU - El-Omar, Emad AU - Hisada, Michie AD - Division of Cancer Epidemiology and Genetics, hisadam@exchange.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 425 EP - 430 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 11 IS - 5 SN - 1083-4389, 1083-4389 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Interleukin 6 KW - Helicobacter pylori KW - Enzyme-linked immunosorbent assay KW - Interleukin 4 KW - Interleukin 2 KW - Tumor necrosis factor KW - Gene polymorphism KW - Interleukin 1 KW - Infection KW - Children KW - Interleukin 10 KW - Inflammation KW - Colonization KW - Interleukin 13 KW - Antibodies KW - Risk factors KW - Polymerase chain reaction KW - Cytokines KW - TLR4 protein KW - Toll-like receptors KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19854354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Helicobacter&rft.atitle=Polymorphisms+in+Cytokine+Genes+and+Risk+of+Helicobacter+pylori+Infection+among+Jamaican+Children&rft.au=Tseng%2C+Fan-Chen%3BBrown%2C+Elizabeth+E%3BMaiese%2C+Eric+M%3BYeager%2C+Meredith%3BWelch%2C+Robert%3BGold%2C+Benjamin+D%3BOwens%2C+Marilyn%3BCranston%2C+Beverly%3BHanchard%2C+Barrie%3BEl-Omar%2C+Emad%3BHisada%2C+Michie&rft.aulast=Tseng&rft.aufirst=Fan-Chen&rft.date=2006-10-01&rft.volume=11&rft.issue=5&rft.spage=425&rft.isbn=&rft.btitle=&rft.title=Helicobacter&rft.issn=10834389&rft_id=info:doi/10.1111%2Fj.1523-5378.2006.00433.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - SuppNotes - Tables, 3; references, 25. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Interleukin 6; Interleukin 4; Enzyme-linked immunosorbent assay; Interleukin 2; Gene polymorphism; Tumor necrosis factor; Interleukin 1; Children; Infection; Interleukin 10; Inflammation; Colonization; Antibodies; Interleukin 13; Risk factors; Cytokines; Polymerase chain reaction; TLR4 protein; Toll-like receptors; Helicobacter pylori DO - http://dx.doi.org/10.1111/j.1523-5378.2006.00433.x ER - TY - JOUR T1 - Toll-like Receptor Recognition Regulates Immunodominance in an Antimicrobial CD4 super(+) T Cell Response AN - 19848489; 7088798 AB - Although Toll-like Receptors (TLRs) play a major function in innate recognition of pathogens, their role in antigen processing and presentation in vivo is poorly understood. Here we establish that Toxoplasma gondii profilin, a TLR11 ligand present in the parasite, is an immunodominant antigen in the CD4 super(+) T cell response to the pathogen. The immunogenicity of profilin was entirely dependent on both TLR11 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88). Selective responsiveness to this parasite protein was regulated at the level of antigen presentation by dendritic cells (DC) and required both TLR signaling and major histocompatibility complex (MHC) class II recognition acting in cis. These findings support a major influence of TLR recognition in antigen presentation by DC in vivo and establish a mechanism by which TLR ligand association regulates the immunogenicity of microbial antigens. JF - Immunity AU - Yarovinsky, Felix AU - Kanzler, Holger AU - Hieny, Sara AU - Coffman, Robert L AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, fyarovinsky@niaid.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 655 EP - 664 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 25 IS - 4 SN - 1074-7613, 1074-7613 KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - PROTEINS KW - CELLIMMUNO KW - MOLIMMUNO KW - Parasites KW - MyD88 protein KW - profilin KW - Major histocompatibility complex KW - Pathogens KW - Antigen presentation KW - Antimicrobial agents KW - Dendritic cells KW - adaptor proteins KW - CD4 antigen KW - Immunogenicity KW - Toxoplasma gondii KW - Lymphocytes T KW - Antigen processing KW - Toll-like receptors KW - Immunodominance KW - Signal transduction KW - K 03350:Immunology KW - A 01340:Antibiotics & Antimicrobials KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=Toll-like+Receptor+Recognition+Regulates+Immunodominance+in+an+Antimicrobial+CD4+super%28%2B%29+T+Cell+Response&rft.au=Yarovinsky%2C+Felix%3BKanzler%2C+Holger%3BHieny%2C+Sara%3BCoffman%2C+Robert+L%3BSher%2C+Alan&rft.aulast=Yarovinsky&rft.aufirst=Felix&rft.date=2006-10-01&rft.volume=25&rft.issue=4&rft.spage=655&rft.isbn=&rft.btitle=&rft.title=Immunity&rft.issn=10747613&rft_id=info:doi/10.1016%2Fj.immuni.2006.07.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Parasites; MyD88 protein; profilin; Major histocompatibility complex; Pathogens; Antigen presentation; Antimicrobial agents; Dendritic cells; CD4 antigen; adaptor proteins; Immunogenicity; Lymphocytes T; Antigen processing; Toll-like receptors; Signal transduction; Immunodominance; Toxoplasma gondii DO - http://dx.doi.org/10.1016/j.immuni.2006.07.015 ER - TY - JOUR T1 - Confronting Complexity: Real-World Immunodominance in Antiviral CD8 super(+) T Cell Responses AN - 19844766; 7088788 AB - Antiviral CD8 super(+) T cells respond to only a minute fraction of the potential peptide determinants encoded by viral genomes. Immunogenic determinants can be ordered into highly reproducible hierarchies based on the magnitude of cognate CD8 super(+) T cell responses. Until recently, this phenomenon, termed immunodominance, was largely defined and characterized in model systems utilizing a few strains of inbred mice infected with a handful of viruses with limited coding capacity. Here, I review work that has extended immunodominance studies to viruses of greater complexity and to the real world of human antiviral immunity. JF - Immunity AU - Yewdell, Jonathan W AD - Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, jyewdell@nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 533 EP - 543 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 25 IS - 4 SN - 1074-7613, 1074-7613 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - Genomes KW - Immunogenicity KW - Reviews KW - Lymphocytes T KW - Inbreeding KW - CD8 antigen KW - Immune response KW - Immunity KW - Immunodominance KW - A 01340:Antibiotics & Antimicrobials KW - V 22350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19844766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=Confronting+Complexity%3A+Real-World+Immunodominance+in+Antiviral+CD8+super%28%2B%29+T+Cell+Responses&rft.au=Yewdell%2C+Jonathan+W&rft.aulast=Yewdell&rft.aufirst=Jonathan&rft.date=2006-10-01&rft.volume=25&rft.issue=4&rft.spage=533&rft.isbn=&rft.btitle=&rft.title=Immunity&rft.issn=10747613&rft_id=info:doi/10.1016%2Fj.immuni.2006.09.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Immunogenicity; Reviews; Lymphocytes T; Inbreeding; Immunity; Immune response; CD8 antigen; Immunodominance DO - http://dx.doi.org/10.1016/j.immuni.2006.09.005 ER - TY - JOUR T1 - Selection and Optimization of Hydrolysis Conditions for the Quantification of Urinary Metabolites of MDMA AN - 19809175; 8641097 AB - Recovery of 3,4-methylenedioxymethamphetamine (MDMA) urinary metabolites requires optimization of the hydrolysis of 4-hydroxy-3-methyoxymethamphetamine (HMMA), 4-hydroxy-3-methoxyamphetamine (HMA), and 3,4-methylenedioxyamphetamine (MDA) conjugates prior to chromatographic analysis. Acidic and enzymatic hydrolysis with b-glucuronidase from Escherichia coli and Helix pomatia were evaluated. Acid hydrolysis yielded 40.0% and 39.3% higher HMA recovery compared to E. coli and H. pomatia hydrolysis, respectively (SE = 9.8 and 11.4%). E. coli b-glucuronidase hydrolysis MDA recovery was 17.1% and 26.5% greater than acid hydrolysis and H. pomatia b-glucuronidase recovery (SE = 3.3 and 6.1%), respectively. HMMA recovery by acid hydrolysis was 336.1% and 159.8% greater than E. coli and H. pomatia b-glucuronidase (SE = 72.8 and 31.6%), respectively. The effects of temperature, time, and acid amount on metabolite recovery were also evaluated. HMA and HMMA acid hydrolysis recoveries were improved at 100 degree C and above. Effective hydrolysis could be conducted in a dry block heater, GC oven, or autoclave at temperatures from 100 to 140 degree C. Optimal hydrolysis conditions for the measurement of MDMA metabolite conjugates were addition of 100 mu L of hydrochloric acid to 1 mL urine and incubation at 120 degree C in a GC oven for 40 min. Therefore, based on HMMA, HMA, and MDA recoveries, time efficiency, availability of instrumentation, and cost, acid hydrolysis was preferred to enzyme hydrolysis. JF - Journal of Analytical Toxicology AU - Pirnay, SO AU - Abraham, T T AU - Lowe, R H AU - Huestis, MA AD - Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 563 EP - 569 VL - 30 IS - 8 SN - 0146-4760, 0146-4760 KW - Microbiology Abstracts B: Bacteriology; Toxicology Abstracts KW - Temperature effects KW - Helix pomatia KW - Guanylate cyclase KW - beta -Glucuronidase KW - Urine KW - Escherichia coli KW - Enzymes KW - Metabolites KW - Hydrolysis KW - MDMA KW - Hydrochloric acid KW - X 24380:Social Poisons & Drug Abuse KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19809175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Analytical+Toxicology&rft.atitle=Selection+and+Optimization+of+Hydrolysis+Conditions+for+the+Quantification+of+Urinary+Metabolites+of+MDMA&rft.au=Pirnay%2C+SO%3BAbraham%2C+T+T%3BLowe%2C+R+H%3BHuestis%2C+MA&rft.aulast=Pirnay&rft.aufirst=SO&rft.date=2006-10-01&rft.volume=30&rft.issue=8&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Journal+of+Analytical+Toxicology&rft.issn=01464760&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Temperature effects; Guanylate cyclase; beta -Glucuronidase; Urine; Enzymes; Metabolites; MDMA; Hydrolysis; Hydrochloric acid; Helix pomatia; Escherichia coli ER - TY - JOUR T1 - Klf4 Cooperates with Oct3/4 and Sox2 To Activate the Lefty1 Core Promoter in Embryonic Stem Cells AN - 19786971; 7125253 AB - Although the POU transcription factor Oct3/4 is pivotal in maintaining self renewal of embryonic stem (ES) cells, little is known of its molecular mechanisms. We previously reported that the N-terminal transactivation domain of Oct3/4 is required for activation of Lefty1 expression (H. Niwa, S. Masui, I. Chambers, A. G. Smith, and J. Miyazaki, Mol. Cell. Biol. 22:1526-1536, 2002). Here we test whether Lefty1 is a direct target of Oct3/4. We identified an ES cell-specific enhancer upstream of the Lefty1 promoter that contains binding sites for Oct3/4 and Sox2. Unlike other known Oct3/4-Sox2-dependent enhancers, however, this enhancer element could not be activated by Oct3/4 and Sox2 in differentiated cells. By functional screening of ES-specific transcription factors, we found that Krueppel-like factor 4 (Klf4) cooperates with Oct3/4 and Sox2 to activate Lefty1 expression, and that Klf4 acts as a mediating factor that specifically binds to the proximal element of the Lefty1 promoter. DNA microarray analysis revealed that a subset of putative Oct3/4 target genes may be regulated in the same manner. Our findings shed light on a novel function of Oct3/4 in ES cells. JF - Molecular and Cellular Biology AU - Nakatake, Yuhki AU - Fukui, Nobutaka AU - Iwamatsu, Yuko AU - Masui, Shinji AU - Takahashi, Kadue AU - Yagi, Rika AU - Yagi, Kiyohito AU - Miyazaki, Jun-ichi AU - Matoba, Ryo AU - Ko, Minoru SH AU - Niwa, Hitoshi AD - Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology (CDB), Minatojima-Minamimachi 2-2-3, Chuo-ku, Kobe 650-0047, Japan. Graduate School of Pharmaceutical Sciences, Osaka University, Yamadaoka 1-6, Suita C., Osaka 565-0871, Japan. Stem Cell Regulation Research, Area of Molecular Therapeutics, Course of Advanced Medicine, Osaka University Graduate School of Medicine, Yamadaoka 2-2, Suita C., Osaka 565-0871, Japan. Developmental Genomics and Aging Section, Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224. Laboratory for Development and Regenerative Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunokicho, Chu-o-ku, Kobe, Hyogo 650-0017, Japan Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 7772 EP - 7782 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 26 IS - 20 SN - 0270-7306, 0270-7306 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Enhancers KW - Promoters KW - Molecular modelling KW - Stem cells KW - Embryo cells KW - Transcription factors KW - Self KW - KLF4 protein KW - Oct-4 protein KW - Krueppel-like factor 4 KW - DNA microarrays KW - W 30910:Imaging KW - G 07730:Development & Cell Cycle KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19786971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Klf4+Cooperates+with+Oct3%2F4+and+Sox2+To+Activate+the+Lefty1+Core+Promoter+in+Embryonic+Stem+Cells&rft.au=Nakatake%2C+Yuhki%3BFukui%2C+Nobutaka%3BIwamatsu%2C+Yuko%3BMasui%2C+Shinji%3BTakahashi%2C+Kadue%3BYagi%2C+Rika%3BYagi%2C+Kiyohito%3BMiyazaki%2C+Jun-ichi%3BMatoba%2C+Ryo%3BKo%2C+Minoru+SH%3BNiwa%2C+Hitoshi&rft.aulast=Nakatake&rft.aufirst=Yuhki&rft.date=2006-10-01&rft.volume=26&rft.issue=20&rft.spage=7772&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Biology&rft.issn=02707306&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Promoters; Enhancers; Stem cells; Embryo cells; Transcription factors; Self; KLF4 protein; Krueppel-like factor 4; Oct-4 protein; DNA microarrays ER - TY - JOUR T1 - Human Pharmacogenomic Variations and Their Implications for Antifungal Efficacy AN - 19785302; 7121928 AB - Pharmacogenomics is defined as the study of the impacts of heritable traits on pharmacology and toxicology. Candidate genes with potential pharmacogenomic importance include drug transporters involved in absorption and excretion, phase I enzymes (e.g., cytochrome P450-dependent mixed-function oxidases) and phase II enzymes (e.g., glucuronosyltransferases) contributing to metabolism, and those molecules (e.g., albumin, A1-acid glycoprotein, and lipoproteins) involved in the distribution of antifungal compounds. By using the tools of population genetics to define interindividual differences in drug absorption, distribution, metabolism, and excretion, pharmacogenomic models for genetic variations in antifungal pharmacokinetics can be derived. Pharmacogenomic factors may become especially important in the treatment of immunocompromised patients or those with persistent or refractory mycoses that cannot be explained by elevated MICs and where rational dosage optimization of the antifungal agent may be particularly critical. Pharmacogenomics has the potential to shift the paradigm of therapy and to improve the selection of antifungal compounds and adjustment of dosage based upon individual variations in drug absorption, metabolism, and excretion. JF - Clinical Microbiology Reviews AU - Meletiadis, Joseph AU - Chanock, Stephen AU - Walsh, Thomas J AD - Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 763 EP - 787 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 19 IS - 4 SN - 0893-8512, 0893-8512 KW - Genetics Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Cytochromes KW - Glucuronosyltransferase KW - Antifungal agents KW - pharmacogenomics KW - Pharmacology KW - Drug metabolism KW - Enzymes KW - Drug development KW - Minimum inhibitory concentration KW - Pharmacokinetics KW - Models KW - Population genetics KW - Reviews KW - Immunocompromised hosts KW - Albumin KW - Lipoproteins KW - Excretion KW - Glycoproteins KW - Drugs KW - Metabolism KW - A 01340:Antibiotics & Antimicrobials KW - K 03400:Human Diseases KW - G 07780:Fungi UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19785302?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Microbiology+Reviews&rft.atitle=Human+Pharmacogenomic+Variations+and+Their+Implications+for+Antifungal+Efficacy&rft.au=Meletiadis%2C+Joseph%3BChanock%2C+Stephen%3BWalsh%2C+Thomas+J&rft.aulast=Meletiadis&rft.aufirst=Joseph&rft.date=2006-10-01&rft.volume=19&rft.issue=4&rft.spage=763&rft.isbn=&rft.btitle=&rft.title=Clinical+Microbiology+Reviews&rft.issn=08938512&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cytochromes; Antifungal agents; Glucuronosyltransferase; Pharmacology; pharmacogenomics; Drug metabolism; Enzymes; Drug development; Minimum inhibitory concentration; Pharmacokinetics; Models; Population genetics; Immunocompromised hosts; Reviews; Lipoproteins; Albumin; Excretion; Glycoproteins; Drugs; Metabolism ER - TY - JOUR T1 - The surprising complexity of signal sequences AN - 19638645; 7371606 AB - Most secreted and many membrane proteins contain cleavable N-terminal signal sequences that mediate their targeting to and translocation across the endoplasmic reticulum or bacterial cytoplasmic membrane. Recent studies have identified many exceptions to the widely held view that signal sequences are simple, degenerate and interchangeable. Growing evidence indicates that signal sequences contain information that specifies the choice of targeting pathway, the efficiency of translocation, the timing of cleavage and even postcleavage functions. As a consequence, signal sequences can have important roles in modulating protein biogenesis. Based on a synthesis of studies in numerous experimental systems, we propose that substrate-specific sequence elements embedded in a conserved domain structure impart unique and physiologically important functionality to signal sequences. JF - Trends in Biochemical Sciences AU - Hegde, R S AU - Bernstein, H D AD - Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, hegder@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 563 EP - 571 VL - 31 IS - 10 SN - 0968-0004, 0968-0004 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Endoplasmic reticulum KW - Reviews KW - Cytoplasmic membranes KW - Conserved sequence KW - Membrane proteins KW - Translocation KW - N 14815:Nucleotide Sequence KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19638645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Biochemical+Sciences&rft.atitle=The+surprising+complexity+of+signal+sequences&rft.au=Hegde%2C+R+S%3BBernstein%2C+H+D&rft.aulast=Hegde&rft.aufirst=R&rft.date=2006-10-01&rft.volume=31&rft.issue=10&rft.spage=563&rft.isbn=&rft.btitle=&rft.title=Trends+in+Biochemical+Sciences&rft.issn=09680004&rft_id=info:doi/10.1016%2Fj.tibs.2006.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Endoplasmic reticulum; Reviews; Cytoplasmic membranes; Conserved sequence; Membrane proteins; Translocation DO - http://dx.doi.org/10.1016/j.tibs.2006.08.004 ER - TY - JOUR T1 - Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites AN - 19518448; 7167327 AB - Indolicidin is a host defense tridecapeptide that inhibits the catalytic activity of HIV-1 integrase in vitro. Here we have elucidated its mechanism of integrase inhibition. Using crosslinking and mass spectrometric footprinting approaches, we found that indolicidin interferes with formation of the catalytic integrase-DNA complex by directly binding DNA. Further characterization revealed that the peptide forms covalent links with abasic sites. Indolicidin crosslinks single- or double-stranded DNAs and various positions of the viral cDNA with comparable efficiency. Using truncated and chemically modified peptides, we show that abasic site crosslinking is independent of the PWWP motif but involves the indolicidin unique lysine residue and the N- and C- terminal NH sub(2) groups. Because indolicidin can also inhibit topoisomerase I, we believe that multiple actions at the level of DNA might be a common property of antimicrobial peptides. JF - Nucleic Acids Research AU - Marchand, Christophe AU - Krajewski, Krzysztof AU - Lee, Hsiu-Fang AU - Antony, Smitha AU - Johnson, Allison A AU - Amin, Ronak AU - Roller, Peter AU - Kvaratskhelia, Mamuka AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology, Center for Cancer Research Building 37, Room 5068 National Cancer Institute, National Institutes of Health Bethesda, MD 20892-4255, USA. Laboratory of Medicinal Chemistry, Center for Cancer Research National Cancer Institute, Frederick, MD 21702, USA. College of Pharmacy, Center for Retrovirus Research and Comprehensive Cancer Center The Ohio State University Health Sciences Center, Columbus, OH 43210, USA Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 5157 EP - 5165 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 34 IS - 18 SN - 0305-1048, 0305-1048 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Virology & AIDS Abstracts KW - Footprinting KW - Human immunodeficiency virus 1 KW - Indolicidin KW - DNA KW - DNA topoisomerase KW - Lysine KW - Antimicrobial peptides KW - Integrase KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - N 14835:Protein-Nucleic Acids Association UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19518448?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nucleic+Acids+Research&rft.atitle=Covalent+binding+of+the+natural+antimicrobial+peptide+indolicidin+to+DNA+abasic+sites&rft.au=Marchand%2C+Christophe%3BKrajewski%2C+Krzysztof%3BLee%2C+Hsiu-Fang%3BAntony%2C+Smitha%3BJohnson%2C+Allison+A%3BAmin%2C+Ronak%3BRoller%2C+Peter%3BKvaratskhelia%2C+Mamuka%3BPommier%2C+Yves&rft.aulast=Marchand&rft.aufirst=Christophe&rft.date=2006-10-01&rft.volume=34&rft.issue=18&rft.spage=5157&rft.isbn=&rft.btitle=&rft.title=Nucleic+Acids+Research&rft.issn=03051048&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Footprinting; Indolicidin; DNA topoisomerase; DNA; Lysine; Antimicrobial peptides; Integrase; Human immunodeficiency virus 1 ER - TY - JOUR T1 - Genomics update: A square archaeon, the smallest eukaryote and the largest bacteria AN - 19507868; 7089532 JF - Environmental Microbiology AU - Galperin, Michael Y Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1683 EP - 1687 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 8 IS - 10 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - Eukaryotes KW - Archaea KW - genomics KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19507868?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Genomics+update%3A+A+square+archaeon%2C+the+smallest+eukaryote+and+the+largest+bacteria&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-10-01&rft.volume=8&rft.issue=10&rft.spage=1683&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2006.01131.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-02-01 N1 - SuppNotes - Tables, 1; references, 34. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Eukaryotes; genomics; Archaea DO - http://dx.doi.org/10.1111/j.1462-2920.2006.01131.x ER - TY - JOUR T1 - Uptake and elimination of ethanol by young zebrafish embryos AN - 19506517; 7203389 AB - Among animal models being explored to understand ethanol-induced teratogenesis, the zebrafish (Danio rerio) is attracting attention because its embryonic development is well characterized and readily visualized. Despite the potential of the zebrafish embryo in research on developmental anomalies produced by ethanol exposure, little is known about the relationship between embryonic ethanol content and the nature/severity of ethanol-mediated deficits. Here, using gas chromatography and radiometry of labeled ethanol carbon, we examine accumulation and clearance of ethanol by dechorionated zebrafish embryos during blastulation/gastrulation. Our data indicate that: (a) rates of uptake and loss of ethanol are directly proportional to the extra-/intra-embryonic ethanol concentration gradient and (b) ethanol in the water fraction of embryos reaches near equimolarity with ethanol in the exposure medium. It appears that, within a wide range of exposure concentrations, embryonic ethanol content can be predicted accurately according to exposure time. Furthermore, it appears that embryonic ethanol can be adjusted rapidly to and maintained at a targeted concentration. JF - Neurotoxicology and Teratology AU - Bradfield, J Y AU - West, J R AU - Maier, SE AD - College of Medicine, The Texas A&M University System Health Science Center, TAMU 1114, College Station, Texas 77843-1114, USA, maiers@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 629 EP - 633 PB - Elsevier Science Inc., Box 882 New York NY 10159 USA, [mailto:usinfo-f@elsevier.com] VL - 28 IS - 5 SN - 0892-0362, 0892-0362 KW - Zebra danio KW - Zebra fish KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Danio rerio KW - Gastrulation KW - Embryogenesis KW - Carbon KW - Radiometry KW - Gas chromatography KW - Animal models KW - Embryos KW - Development KW - Teratogenesis KW - Ethanol KW - N3 11003:Developmental neuroscience KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19506517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology+and+Teratology&rft.atitle=Uptake+and+elimination+of+ethanol+by+young+zebrafish+embryos&rft.au=Bradfield%2C+J+Y%3BWest%2C+J+R%3BMaier%2C+SE&rft.aulast=Bradfield&rft.aufirst=J&rft.date=2006-10-01&rft.volume=28&rft.issue=5&rft.spage=629&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology+and+Teratology&rft.issn=08920362&rft_id=info:doi/10.1016%2Fj.ntt.2006.06.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Embryogenesis; Gastrulation; Carbon; Radiometry; Gas chromatography; Animal models; Embryos; Development; Teratogenesis; Ethanol; Danio rerio DO - http://dx.doi.org/10.1016/j.ntt.2006.06.004 ER - TY - JOUR T1 - Re-engineering Primary Epithelial Cells from Rhesus Monkey Parotid Glands for Use in Developing an Artificial Salivary Gland AN - 19495193; 7194994 AB - There is no satisfactory conventional treatment for patients who experience irreversible salivary gland damage after therapeutic radiation for head and neck cancer or because of Sjoegren's syndrome. Additionally, if most parenchyma is lost, these patients also are not candidates for evolving gene transfer strategies. To help such patients, several years ago we began to develop an artificial salivary gland. In the present study, we used a non-human primate tissue source, parotid glands from rhesus monkeys, to obtain potential autologous graft cells for development of a prototype device for in situ testing. Herein, we present 3 major findings. First, we show that primary cultures of rhesus parotid gland (RPG) cells are capable of attaining a polarized orientation, with Na super(+)/K super(+)-adenosine triphosphatase, zonula occludens-1, and claudin-1 distributed in specific domains appropriate for epithelial cells. Second, we show that RPG cells exhibit 2 essential epithelial functions required for graft cells in an artificial salivary gland device (i.e., an effective barrier to paracellular water flow and the generation of a moderate transepithelial electrical resistance). Third, we show that RPG cells can express functional water channels, capable of mediating directional fluid movement, after transduction by adenoviral and adeno-associated virus type 2 vectors. Together these results demonstrate that it is feasible to individually prepare RPG cells for eventual use in a prototype artificial salivary gland. JF - Tissue Engineering AU - Tran, S D AU - Sugito, T AU - Dipasquale, G AU - Cotrim, A P AU - Bandyopadhyay, B C AU - Riddle, K AU - Mooney, D AU - Kok, M R AU - Chiorini, JA AU - Baum, B J AD - GTTB, NIDCR, NIH, DHHS, Building 10, Room 1N113, Bethesda, MD 20892-1190, USA, bbaum@dir.nidcr.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2939 EP - 2948 VL - 12 IS - 10 SN - 1076-3279, 1076-3279 KW - Primates KW - Rhesus macaque KW - Rhesus monkey KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Parenchyma KW - Autografts KW - Epithelial cells KW - Water flow KW - Parotid gland KW - aquaporins KW - Cell culture KW - Zonula occludens-1 protein KW - Tissue engineering KW - Salivary gland KW - Adeno-associated virus 2 KW - Sjogren's syndrome KW - Expression vectors KW - Triphosphatase KW - Gene transfer KW - Head and neck cancer KW - Macaca mulatta KW - V 22410:Animal Diseases KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19495193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=Re-engineering+Primary+Epithelial+Cells+from+Rhesus+Monkey+Parotid+Glands+for+Use+in+Developing+an+Artificial+Salivary+Gland&rft.au=Tran%2C+S+D%3BSugito%2C+T%3BDipasquale%2C+G%3BCotrim%2C+A+P%3BBandyopadhyay%2C+B+C%3BRiddle%2C+K%3BMooney%2C+D%3BKok%2C+M+R%3BChiorini%2C+JA%3BBaum%2C+B+J&rft.aulast=Tran&rft.aufirst=S&rft.date=2006-10-01&rft.volume=12&rft.issue=10&rft.spage=2939&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=10763279&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Autografts; Parenchyma; Epithelial cells; Water flow; aquaporins; Parotid gland; Zonula occludens-1 protein; Cell culture; Salivary gland; Tissue engineering; Expression vectors; Sjogren's syndrome; Triphosphatase; Gene transfer; Head and neck cancer; Adeno-associated virus 2; Macaca mulatta ER - TY - JOUR T1 - New metrics for comparative genomics AN - 19483372; 7078359 AB - The availability of genome sequences from a variety of organisms presents an opportunity to apply this sequence information to solving the key problems of molecular biology. One of the principal roadblocks on this path is the lack of appropriate descriptors and metrics that could succinctly represent the new knowledge stemming from the genomic data. Several new metrics have recently been used in comparative genome analysis, yet challenges remain in finding an appropriate language for the emerging discipline of systems biology. JF - Current Opinion in Biotechnology AU - Galperin, Michael Y AU - Kolker, Eugene AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, galperin@ncbi.nlm.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 440 EP - 447 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 5 SN - 0958-1669, 0958-1669 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Data processing KW - Reviews KW - Nucleotide sequence KW - Language KW - genomics KW - G 07880:Human Genetics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19483372?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=New+metrics+for+comparative+genomics&rft.au=Galperin%2C+Michael+Y%3BKolker%2C+Eugene&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-10-01&rft.volume=17&rft.issue=5&rft.spage=440&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.08.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Data processing; Nucleotide sequence; Reviews; Language; genomics DO - http://dx.doi.org/10.1016/j.copbio.2006.08.007 ER - TY - JOUR T1 - Effects of binge eating on satiation, satiety, and energy intake of overweight children AN - 19472929; 7158738 AB - Background: Children who report episodes of binge eating gain more weight than do children not reporting binge eating. However, how binge eating affects children's food intake at meals is unknown. Objective: We compared the energy intake and postmeal satiety of children with and without a history of binge eating during buffet meals. Design: Sixty overweight children aged 6-12 y were categorized into those reporting past binge-eating episodes (n = 10) and those reporting no such episodes (n = 50). Children selected lunch twice from a multiple-item, 9835 kcal, buffet meal: after an overnight fast and after a standardized breakfast. Children ate ad libitum, until they reported they were full. The main outcome measures were energy intake during meals and duration of postmeal satiety, after adjustment for covariates, including age, race, sex, socioeconomic status, and body composition. Results: After the overnight fast, children in the binge-eating group consumed more energy [x ( plus or minus SD): 1748 plus or minus 581 compared with 1309 plus or minus 595 kcal; P = 0.04] and exhibited a shorter satiety duration (194 plus or minus 84 compared with 262 plus or minus 89 min; P = 0.03) than did children in the non-binge-eating group. After the standardized breakfast, binge-eating children reported a shorter satiety duration (75 plus or minus 62 compared with 132 plus or minus 62 min; P = 0.01) and consumed more energy at the postbreakfast meal (1874 plus or minus 560 compared with 1275 plus or minus 566 kcal; P = 0.004). Conclusion: The ability to consume large quantities of palatable foods, coupled with decreased subsequent satiety, may play a role in the greater weight gain found in binge-eating children. JF - `merican Journal of Clinical Nutrition AU - Mirch, M C AU - McDuffie, J R AU - Yanovski, S Z AU - Schollnberger, M AU - Tanofsky-Kraff, M AU - Theim, K R AU - Krakoff, J AU - Yanovski, JA AD - Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development (NICHD); the Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); the Nutrition Department, Hatfield Clinical Research Center; and the Phoenix Epidemiology and Clinical Research Branch, NIDDK, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 732 EP - 738 PB - American Society for Clinical Nutrition, 3247 Meyer Hall, University of California One Shields Avenue Davis CA 95616-8790 USA, [mailto:AJCN@UCDAVIS.EDU], [URL:http://www.ajcn.org/] VL - 84 IS - 4 SN - 0002-9165, 0002-9165 KW - Physical Education Index KW - Obesity KW - Socioeconomic factors KW - Age KW - Play KW - Weight KW - Diet KW - Children KW - Body composition KW - Nutrition KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19472929?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=%60merican+Journal+of+Clinical+Nutrition&rft.atitle=Effects+of+binge+eating+on+satiation%2C+satiety%2C+and+energy+intake+of+overweight+children&rft.au=Mirch%2C+M+C%3BMcDuffie%2C+J+R%3BYanovski%2C+S+Z%3BSchollnberger%2C+M%3BTanofsky-Kraff%2C+M%3BTheim%2C+K+R%3BKrakoff%2C+J%3BYanovski%2C+JA&rft.aulast=Mirch&rft.aufirst=M&rft.date=2006-10-01&rft.volume=84&rft.issue=4&rft.spage=732&rft.isbn=&rft.btitle=&rft.title=%60merican+Journal+of+Clinical+Nutrition&rft.issn=00029165&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Age; Socioeconomic factors; Play; Weight; Diet; Body composition; Children; Nutrition; Sex ER - TY - JOUR T1 - A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer AN - 19465680; 7121714 AB - PURPOSE: A phase I study was conducted to assess the safety of adoptive immunotherapy using gene-modified autologous T cells for the treatment of metastatic ovarian cancer. Experimental Design: T cells with reactivity against the ovarian cancer-associated antigen alpha -folate receptor (FR) were generated by genetic modification of autologous T cells with a chimeric gene incorporating an anti-FR single-chain antibody linked to the signaling domain of the Fc receptor gamma chain. Patients were assigned to one of two cohorts in the study. Eight patients in cohort 1 received a dose escalation of T cells in combination with high-dose interleukin-2, and six patients in cohort 2 received dual-specific T cells (reactive with both FR and allogeneic cells) followed by immunization with allogeneic peripheral blood mononuclear cells. RESULTS: Five patients in cohort 1 experienced some grade 3 to 4 treatment-related toxicity that was probably due to interleukin-2 administration, which could be managed using standard measures. Patients in cohort 2 experienced relatively mild side effects with grade 1 to 2 symptoms. No reduction in tumor burden was seen in any patient. Tracking super(111)In-labeled adoptively transferred T cells in cohort 1 revealed a lack of specific localization of T cells to tumor except in one patient where some signal was detected in a peritoneal deposit. PCR analysis showed that gene-modified T cells were present in the circulation in large numbers for the first 2 days after transfer, but these quickly declined to be barely detectable 1 month later in most patients. An inhibitory factor developed in the serum of three of six patients tested over the period of treatment, which significantly reduced the ability of gene-modified T cells to respond against FR super(+) tumor cells. CONCLUSIONS: Large numbers of gene-modified tumor-reactive T cells can be safely given to patients, but these cells do not persist in large numbers long term. Future studies need to employ strategies to extend T cell persistence. This report is the first to document the use of genetically redirected T cells for the treatment of ovarian cancer. JF - Clinical Cancer Research AU - Kershaw, Michael H AU - Westwood, Jennifer A AU - Parker, Linda L AU - Wang, Gang AU - Eshhar, Zelig AU - Mavroukakis, Sharon A AU - White, Donald E AU - Wunderlich, John R AU - Canevari, Silvana AU - Rogers-Freezer, Linda AU - Chen, Clara C AU - Yang, James C AU - Rosenberg, Steven A AU - Hwu, Patrick AD - Authors' Affiliations: Surgery Branch, Center for Cancer Research, National Cancer Institute Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 6106 EP - 6115 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 12 IS - 20 SN - 1078-0432, 1078-0432 KW - Toxicology Abstracts; Genetics Abstracts; Immunology Abstracts; Biotechnology and Bioengineering Abstracts KW - Deposits KW - Ovarian cancer KW - Interleukin 2 KW - double prime Fc receptors KW - Peritoneum KW - Toxicity KW - Tumors KW - Tumor cells KW - Fc receptors KW - Metastases KW - Peripheral blood mononuclear cells KW - Antibodies KW - Adoptive immunotherapy KW - Lymphocytes T KW - Polymerase chain reaction KW - Side effects KW - Signal transduction KW - G 07880:Human Genetics KW - X 24310:Pharmaceuticals KW - F 06915:Cancer Immunology KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19465680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+Cancer+Research&rft.atitle=A+Phase+I+Study+on+Adoptive+Immunotherapy+Using+Gene-Modified+T+Cells+for+Ovarian+Cancer&rft.au=Kershaw%2C+Michael+H%3BWestwood%2C+Jennifer+A%3BParker%2C+Linda+L%3BWang%2C+Gang%3BEshhar%2C+Zelig%3BMavroukakis%2C+Sharon+A%3BWhite%2C+Donald+E%3BWunderlich%2C+John+R%3BCanevari%2C+Silvana%3BRogers-Freezer%2C+Linda%3BChen%2C+Clara+C%3BYang%2C+James+C%3BRosenberg%2C+Steven+A%3BHwu%2C+Patrick&rft.aulast=Kershaw&rft.aufirst=Michael&rft.date=2006-10-01&rft.volume=12&rft.issue=20&rft.spage=6106&rft.isbn=&rft.btitle=&rft.title=Clinical+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; Deposits; double prime Fc receptors; Interleukin 2; Peritoneum; Tumors; Toxicity; Tumor cells; Fc receptors; Metastases; Antibodies; Peripheral blood mononuclear cells; Adoptive immunotherapy; Lymphocytes T; Polymerase chain reaction; Side effects; Signal transduction ER - TY - JOUR T1 - Proteomics in Clinical Trials and Practice: Present Uses and Future Promise AN - 19464981; 7125300 AB - The study of clinical proteomics is a promising new field that has the potential to have many applications, including the identification of biomarkers and monitoring of disease, especially in the field of oncology. Expression proteomics evaluates the cellular production of proteins encoded by a particular gene and exploits the differential expression and post-translational modifications of proteins between healthy and diseased states. These biomarkers may be applied towards early diagnosis, prognosis, and prediction of response to therapy. Functional proteomics seeks to decipher protein-protein interactions and biochemical pathways involved in disease biology and targeted by newer molecular therapeutics. Advanced spectrometry technologies and new protein array formats have improved these analyses and are now being applied prospectively in clinical trials. Further advancement of proteomics technology could usher in an era of personalized molecular medicine, where diseases are diagnosed at earlier stages and where therapies are more effective because they are tailored to the protein expression of a patient's malignancy. JF - Molecular and Cellular Proteomics AU - Azad, Nilofer S AU - Rasool, Nabila AU - Annunziata, Christina M AU - Minasian, Lori AU - Whiteley, Gordon AU - Kohn, Elise C AD - Laboratory of Pathology, Molecular Signaling Section, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1819 EP - 1829 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.asbmb.org/] VL - 5 IS - 10 SN - 1535-9476, 1535-9476 KW - Biotechnology and Bioengineering Abstracts KW - Malignancy KW - Post-translation KW - Protein arrays KW - Oncology KW - proteomics KW - Clinical trials KW - biomarkers KW - Protein interaction KW - Spectrometry KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Proteomics&rft.atitle=Proteomics+in+Clinical+Trials+and+Practice%3A+Present+Uses+and+Future+Promise&rft.au=Azad%2C+Nilofer+S%3BRasool%2C+Nabila%3BAnnunziata%2C+Christina+M%3BMinasian%2C+Lori%3BWhiteley%2C+Gordon%3BKohn%2C+Elise+C&rft.aulast=Azad&rft.aufirst=Nilofer&rft.date=2006-10-01&rft.volume=5&rft.issue=10&rft.spage=1819&rft.isbn=&rft.btitle=&rft.title=Molecular+and+Cellular+Proteomics&rft.issn=15359476&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - proteomics; biomarkers; Clinical trials; Malignancy; Spectrometry; Post-translation; Protein interaction; Protein arrays; Oncology ER - TY - JOUR T1 - Caught in the act: The impact of audience on the neural response to morally and socially inappropriate behavior AN - 19462250; 7072544 AB - We examined the impact of witnesses on the neural response to moral and social transgressions using fMRI. In this study, participants (N = 16) read short vignettes describing moral and social transgressions in the presence or absence of an audience. In line with our hypothesis, ventrolateral (BA 47) and dorsomedial (BA 8) frontal cortex showed increased BOLD responses to moral transgressions regardless of audience and to social transgressions in the presence of an audience relative to neutral situations. These findings are consistent with the suggestion that these regions of prefrontal cortex modify behavioral responses in response to social cues. Greater activity was observed in left temporal-parietal junction, medial prefrontal cortex and temporal poles to moral and to a lesser extent social transgressions relative to neutral stories, regardless of audience. These regions have been implicated in the representation of the mental states of others (Theory of Mind). The presence of an audience was associated with increased left amygdala activity across all conditions. JF - NeuroImage AU - Finger, Elizabeth C AU - Marsh, Abigail A AU - Kamel, Niveen AU - Mitchell, Derek GV AU - Blair, James R AD - Mood and Anxiety Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, 15K, North Drive, MSC 2670, Bethesda, MD 20892, USA, fingere@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 414 EP - 421 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 33 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Functional magnetic resonance imaging KW - Ethics KW - Cortex (frontal) KW - Amygdala KW - Cortex (prefrontal) KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19462250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Caught+in+the+act%3A+The+impact+of+audience+on+the+neural+response+to+morally+and+socially+inappropriate+behavior&rft.au=Finger%2C+Elizabeth+C%3BMarsh%2C+Abigail+A%3BKamel%2C+Niveen%3BMitchell%2C+Derek+GV%3BBlair%2C+James+R&rft.aulast=Finger&rft.aufirst=Elizabeth&rft.date=2006-10-01&rft.volume=33&rft.issue=1&rft.spage=414&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Ethics; Cortex (prefrontal); Amygdala; Functional magnetic resonance imaging; Cortex (frontal) DO - http://dx.doi.org/10.1016/j.neuroimage.2006.06.011 ER - TY - JOUR T1 - Contrast-Enhanced Sonography of the Spleen AN - 19461225; 7078950 AB - Sonography is frequently the first imaging modality employed to evaluate the spleen. Nevertheless, splenic abnormalities frequently determine subtle changes in echogenicity and may be overlooked. Additionally, splenic disorders have a nonspecific appearance, mostly appearing as hypoechoic defects. Difficulties in differential diagnosis are not uncommon, with splenic infarctions resembling, for example, focal lesions. Color Doppler is usually of limited additional value. Instead, the spleen is optimally suited for contrast-enhanced sonography, being superficial, small, and homogeneous, and showing intense and persistent contrast enhancement. Scarcely evident abnormalities become evident after contrast medium injection. Additional information can be obtained in many clinical scenarios, including blunt trauma, left flank pain, lymphoma, and incidental detection of splenic abnormalities. JF - Seminars in Ultrasound, CT & MRI AU - Catalano, Orlando AU - Sandomenico, Fabio AU - Vallone, Paolo AU - dErrico, Adolfo Gallipoli AU - Siani, Alfredo AD - Department of Radiology, National Cancer Institute, "Fondazione G.Pascale", Naples, Italy., orlandcat@tin.it Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 426 EP - 433 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 27 IS - 5 SN - 0887-2171, 0887-2171 KW - Biotechnology and Bioengineering Abstracts KW - Differential diagnosis KW - Magnetic resonance imaging KW - Computed tomography KW - Spleen KW - Pain KW - Infarction KW - Lymphoma KW - Ultrasound KW - Trauma KW - Color KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19461225?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+Ultrasound%2C+CT+%26+MRI&rft.atitle=Contrast-Enhanced+Sonography+of+the+Spleen&rft.au=Catalano%2C+Orlando%3BSandomenico%2C+Fabio%3BVallone%2C+Paolo%3BdErrico%2C+Adolfo+Gallipoli%3BSiani%2C+Alfredo&rft.aulast=Catalano&rft.aufirst=Orlando&rft.date=2006-10-01&rft.volume=27&rft.issue=5&rft.spage=426&rft.isbn=&rft.btitle=&rft.title=Seminars+in+Ultrasound%2C+CT+%26+MRI&rft.issn=08872171&rft_id=info:doi/10.1053%2Fj.sult.2006.06.006 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Spleen; Color; Ultrasound; Computed tomography; Infarction; Lymphoma; Differential diagnosis; Pain; Trauma; Magnetic resonance imaging DO - http://dx.doi.org/10.1053/j.sult.2006.06.006 ER - TY - JOUR T1 - The prediction of the wild-type telomerase RNA pseudoknot structure and the pivotal role of the bulge in its formation AN - 19458518; 7070229 AB - In this study, the three-dimensional structure of the wild-type human telomerase RNA pseudoknot was predicted via molecular modeling. The wild-type pseudoknot structure is then compared to the recent NMR solution structure of the telomerase pseudoknot, which does not contain the U177 bulge. The removal of the bulge from the pseudoknot structure results in higher stability and significant reduction of activity of telomerase. We show that the effect of the bulge on the structure results in a significant transformation of the pseudoknot junction region where the starting base pairs are disrupted and unique triple base pairs are formed. We found that the formation of the junction region is greatly influenced by interactions of the U177 bulge with loop residues and rotation of residue A174. Moreover, this is the first study to our knowledge where a structure as complex as the pseudoknot has been solved by purely theoretical methods. JF - Journal of Molecular Graphics and Modelling AU - Yingling, Yaroslava G AU - Shapiro, Bruce A AD - Center for Cancer Research Nanobiology Program, National Cancer Institute, NCI-Frederick, National Institutes of Health, Building 469, Room 150, Frederick, MD 21702, United States, bshapiro@ncifcrf.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 261 EP - 274 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 2 SN - 1093-3263, 1093-3263 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Telomerase KW - RNA KW - Molecular dynamics KW - Theoretical prediction KW - Pseudoknot KW - Transformation KW - Molecular modelling KW - N.M.R. KW - Base pairs KW - N 14830:RNA KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458518?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=The+prediction+of+the+wild-type+telomerase+RNA+pseudoknot+structure+and+the+pivotal+role+of+the+bulge+in+its+formation&rft.au=Yingling%2C+Yaroslava+G%3BShapiro%2C+Bruce+A&rft.aulast=Yingling&rft.aufirst=Yaroslava&rft.date=2006-10-01&rft.volume=25&rft.issue=2&rft.spage=261&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2006.01.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Transformation; Molecular modelling; RNA; Telomerase; N.M.R.; Base pairs DO - http://dx.doi.org/10.1016/j.jmgm.2006.01.003 ER - TY - JOUR T1 - Canonical transient receptor potential channels in disease: targets for novel drug therapy? AN - 19443983; 7145885 AB - The canonical transient receptor potential (TRPC) channels constitute one of the three major families within the large transient receptor potential (TRP) superfamily. TRPC channels are the closest mammalian homologues of Drosophila TRP, the light-activated channel in Drosophila photoreceptor cells. All TRPC channels (TRPC1-7) are activated via phospholipase-C-coupled receptors and were, therefore, proposed to encode elusive native receptor-activated cation channels in many cell types. A physiological role has been established for all of the known TRPC channels, including the control of vascular tone (TRPC1, TRPC4 and TRPC6) or lymphocyte activation, which is essential for immune competence (TRPC1 and TRPC3). The emergence of TRPC channels in controlling a variety of biological functions offers new and promising targets for drug development. JF - Drug Discovery Today AU - Trebak, M AD - National Institute of Environmental Health Sciences (NIEHS), NIH, Research Triangle Park, NC 27709, USA, trebak@niehs.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 924 EP - 930 PB - Elsevier Ltd VL - 11 IS - 19-20 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts; Calcium & Calcified Tissue Abstracts KW - cation channels KW - Reviews KW - Drug development KW - Lymphocytes KW - transient receptor potential proteins KW - Drosophila KW - Drugs KW - Photoreceptors KW - Vascular system KW - Cell activation KW - T 2000:Cellular Calcium KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19443983?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Canonical+transient+receptor+potential+channels+in+disease%3A+targets+for+novel+drug+therapy%3F&rft.au=Trebak%2C+M&rft.aulast=Trebak&rft.aufirst=M&rft.date=2006-10-01&rft.volume=11&rft.issue=19-20&rft.spage=924&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2006.08.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - cation channels; Reviews; Drug development; Lymphocytes; transient receptor potential proteins; Drugs; Photoreceptors; Cell activation; Vascular system; Drosophila DO - http://dx.doi.org/10.1016/j.drudis.2006.08.002 ER - TY - JOUR T1 - Thermodynamics Constrains the Evolution of Insect Population Growth Rates: "Warmer Is Better" AN - 19391438; 7157428 AB - Diverse biochemical and physiological adaptations enable different species of ectotherms to survive and reproduce in very different temperature regimes, but whether these adaptations fully compensate for the thermodynamically depressing effects of low temperature on rates of biological processes is debated. If such adaptations are fully compensatory, then temperature-dependent processes (e.g., digestion rate, population growth rate) of cold-adapted species will match those of warm-adapted species when each is measured at its own optimal temperature. Here we show that cold-adapted insect species have much lower maximum rates of population growth than do warm-adapted species, even when we control for phylogenetic relatedness. This pattern also holds when we use a structural-equation model to analyze alternative hypotheses that might otherwise explain this correlation. Thus, although physiological adaptations enable some insects to survive and reproduce at low temperatures, these adaptations do not overcome the "tyranny" of thermodynamics, at least for rates of population increase. Indeed, the sensitivity of population growth rates of insects to temperature is even greater than predicted by a recent thermodynamic model. Our findings suggest that adaptation to temperature inevitably alters the population dynamics of insects. This result has broad evolutionary and ecological consequences. JF - American Naturalist AU - Frazier, M R AU - Huey, R R AU - Berrigan, D AD - Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Executive Plaza North MSC 7344 (Room 4095B), Bethesda, Maryland 20892, USA, berrigad@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 512 EP - 520 VL - 168 IS - 4 SN - 0003-0147, 0003-0147 KW - Insects KW - Sustainability Science Abstracts; Entomology Abstracts; Ecology Abstracts KW - Temperature effects KW - Digestion KW - Phylogeny KW - Adaptations KW - Thermodynamics KW - Population growth KW - Evolution KW - Insecta KW - Models KW - Z 05340:Ecology and Behavior KW - M3 1010:Issues in Sustainable Development KW - D 04040:Ecosystem and Ecology Studies UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19391438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Naturalist&rft.atitle=Thermodynamics+Constrains+the+Evolution+of+Insect+Population+Growth+Rates%3A+%22Warmer+Is+Better%22&rft.au=Frazier%2C+M+R%3BHuey%2C+R+R%3BBerrigan%2C+D&rft.aulast=Frazier&rft.aufirst=M&rft.date=2006-10-01&rft.volume=168&rft.issue=4&rft.spage=512&rft.isbn=&rft.btitle=&rft.title=American+Naturalist&rft.issn=00030147&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phylogeny; Digestion; Temperature effects; Adaptations; Thermodynamics; Population growth; Evolution; Models; Insecta ER - TY - JOUR T1 - Application of azide-alkyne cycloaddition click chemistry for the synthesis of Grb2 SH2 domain-binding macrocycles AN - 19378321; 7040641 AB - Copper (I) promoted [3+2] Huisgen cycloaddition of azides with terminal alkynes was used to prepare triazole-containing macrocycles based on the Grb2 SH2 domain-binding motif, Pmp-Ac sub(6)c-Asn, where Pmp and Ac sub(6)c stand for 4-phosphonomethylphenylalanine and 1-aminocyclohexanecarboxylic acid, respectively. When cycloaddition reactions were conducted at 1 mM substrate concentrations, cyclization of monomeric units occurred. At 2 mM substrate concentrations the predominant products were macrocyclic dimers. In Grb2 SH2 domain-binding assays the monomeric (S)-Pmp-containing macrocycle exhibited a K sub(d) value of 0.23 mu M, while the corresponding dimeric macrocycle was found to have greater than 50-fold higher affinity. The open-chain dimer was also found to have affinity equal to the dimeric macrocycle. This work represents the first application of click chemistry to the synthesis of SH2 domain-binding inhibitors and indicates its potential utility. JF - Bioorganic and Medicinal Chemistry Letters AU - Choi, Won Jun AU - Shi, Zhen-Dan AU - Worthy, Karen M AU - Bindu, Lakshman AU - Karki, Rajeshri G AU - Nicklaus, Marc C AU - Fisher, Robert J AU - Burke, Terrence R AD - Laboratory of Medicinal Chemistry, CCR, NCI, NIH, Frederick, MD 21702, USA, tburke@helix.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 5265 EP - 5269 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 16 IS - 20 SN - 0960-894X, 0960-894X KW - Biotechnology and Bioengineering Abstracts KW - Macrocycle KW - Click chemistry KW - Grb2 SH2 domain KW - Cycloaddition KW - Peptide mimetic KW - Grb2 protein KW - Copper KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19378321?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry+Letters&rft.atitle=Application+of+azide-alkyne+cycloaddition+click+chemistry+for+the+synthesis+of+Grb2+SH2+domain-binding+macrocycles&rft.au=Choi%2C+Won+Jun%3BShi%2C+Zhen-Dan%3BWorthy%2C+Karen+M%3BBindu%2C+Lakshman%3BKarki%2C+Rajeshri+G%3BNicklaus%2C+Marc+C%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R&rft.aulast=Choi&rft.aufirst=Won&rft.date=2006-10-01&rft.volume=16&rft.issue=20&rft.spage=5265&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry+Letters&rft.issn=0960894X&rft_id=info:doi/10.1016%2Fj.bmcl.2006.08.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Grb2 protein; Copper DO - http://dx.doi.org/10.1016/j.bmcl.2006.08.004 ER - TY - JOUR T1 - IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis AN - 19361930; 7124173 AB - Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that is caused in part by a dysregulated immune response to the intestinal flora. The common interleukin (IL)-12/IL-23p40 subunit is thought to be critical for the pathogenesis of IBD. We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T cell-sufficient hosts, and the other involving CD4 super(+) T cell transfer into infected Rag super(-/-) recipients. Our data demonstrate that IL-23 and not IL-12 is essential for the development of maximal intestinal disease. Although IL-23 has been implicated in the differentiation of IL-17-producing CD4 super(+) T cells that alone are sufficient to induce autoimmune tissue reactivity, our results instead support a model in which IL-23 drives both interferon gamma and IL-17 responses that together synergize to trigger severe intestinal inflammation. JF - Journal of Experimental Medicine AU - Kullberg, Marika C AU - Jankovic, Dragana AU - Feng, Carl G AU - Hue, Sophie AU - Gorelick, Peter L AU - McKenzie, Brent S AU - Cua, Daniel J AU - Powrie, Fiona AU - Cheever, Allen W AU - Maloy, Kevin J AU - Sher, Alan AD - Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892. Immunology and Infection Unit, Department of Biology, University of York and The Hull York Medical School, York YO10 5YW, UK. Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Animal Health Diagnostic Laboratory, Laboratory Animal Sciences Program, National Cancer Institute-FCRDC, Science Applications International Corporation, Frederick, MD 21702. Department of Discovery Research, Schering-Plough Biopharma, Palo Alto, CA 94304. The Biomedical Research Institute, Rockville, MD 20852 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2485 EP - 2494 PB - Rockefeller University Press, 1114 First Avenue New York NY 10021-8325 USA, [mailto:Bruce.Lyons@rockefeller.edu], [URL:http://www.rockefeller.edu/rupress] VL - 203 IS - 11 SN - 0022-1007, 0022-1007 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - gamma -Interferon KW - Synergism KW - Monoclonal antibodies KW - Intestinal microflora KW - Differentiation KW - Interleukin 12 KW - CD4 antigen KW - Digestive tract KW - Interleukin 23 KW - Inflammatory bowel diseases KW - Interleukin 17 KW - Helicobacter hepaticus KW - Lymphocytes T KW - Intestine KW - Colitis KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19361930?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Experimental+Medicine&rft.atitle=IL-23+plays+a+key+role+in+Helicobacter+hepaticus-induced+T+cell-dependent+colitis&rft.au=Kullberg%2C+Marika+C%3BJankovic%2C+Dragana%3BFeng%2C+Carl+G%3BHue%2C+Sophie%3BGorelick%2C+Peter+L%3BMcKenzie%2C+Brent+S%3BCua%2C+Daniel+J%3BPowrie%2C+Fiona%3BCheever%2C+Allen+W%3BMaloy%2C+Kevin+J%3BSher%2C+Alan&rft.aulast=Kullberg&rft.aufirst=Marika&rft.date=2006-10-01&rft.volume=203&rft.issue=11&rft.spage=2485&rft.isbn=&rft.btitle=&rft.title=Journal+of+Experimental+Medicine&rft.issn=00221007&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Synergism; Monoclonal antibodies; Interleukin 12; Differentiation; Intestinal microflora; CD4 antigen; Interleukin 23; Digestive tract; Inflammatory bowel diseases; Interleukin 17; Intestine; Lymphocytes T; Colitis; Helicobacter hepaticus ER - TY - JOUR T1 - Chlamydial TARP is a bacterial nucleator of actin AN - 19360086; 7126326 AB - Chlamydia trachomatis entry into host cells results from a parasite-directed remodeling of the actin cytoskeleton. A type III secreted effector, TARP (translocated actin recruiting phosphoprotein), has been implicated in the recruitment of actin to the site of internalization. To elucidate the role of TARP in actin recruitment, we identified host cell proteins that associated with recombinant GST-TARP fusions. TARP directly associated with actin, and this interaction promoted actin nucleation as determined by in vitro polymerization assays. Domain analysis of TARP identified an actin-binding domain that bears structural and primary amino acid sequence similarity to WH2 domain family proteins. In addition, a proline-rich domain was found to promote TARP oligomerization and was required for TARP-dependent nucleation of new actin filaments. Our findings reveal a mechanism by which chlamydiae induce localized cytoskeletal changes by the translocated effector TARP during entry into host cells. JF - Proceedings of the National Academy of Sciences, USA AU - Jewett, Travis J AU - Fischer, Elizabeth R AU - Mead, David J AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, and RTS Microscopy Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 15599 EP - 15604 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 42 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Nucleation KW - Cytoskeleton KW - Bacteria KW - Polymerization KW - Phosphoproteins KW - Oligomerization KW - Chlamydia trachomatis KW - Actin KW - Filaments KW - Amino acid sequence KW - J 02330:Biochemistry KW - A 01310:Products of Microorganisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19360086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Chlamydial+TARP+is+a+bacterial+nucleator+of+actin&rft.au=Jewett%2C+Travis+J%3BFischer%2C+Elizabeth+R%3BMead%2C+David+J%3BHackstadt%2C+Ted&rft.aulast=Jewett&rft.aufirst=Travis&rft.date=2006-10-01&rft.volume=103&rft.issue=42&rft.spage=15599&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cytoskeleton; Nucleation; Polymerization; Phosphoproteins; Oligomerization; Actin; Filaments; Amino acid sequence; Bacteria; Chlamydia trachomatis ER - TY - JOUR T1 - Direct magnetic resonance detection of neuronal electrical activity AN - 19359418; 7126399 AB - Present noninvasive neuroimaging methods measure neuronal activity indirectly, via either cerebrovascular changes or extracranial measurements of electrical/magnetic signals. Recent studies have shown evidence that MRI may be used to directly and noninvasively map electrical activity associated with human brain activation, but results are inconclusive. Here, we show that MRI can detect cortical electrical activity directly. We use organotypic rat-brain cultures in vitro that are spontaneously active in the absence of a cerebrovascular system. Single-voxel magnetic resonance (MR) measurements obtained at 7 T were highly correlated with multisite extracellular local field potential recordings of the same cultures before and after blockade of neuronal activity with tetrodotoxin. Similarly, for MR images obtained at 3 T, the MR signal changed solely in voxels containing the culture, thus allowing the spatial localization of the active neuronal tissue. JF - Proceedings of the National Academy of Sciences, USA AU - Petridou, Natalia AU - Plenz, Dietmar AU - Silva, Afonso C AU - Loew, Murray AU - Bodurka, Jerzy AU - Bandettini, Peter A AD - Section on Functional Imaging Methods, Laboratory of Brain and Cognition, Neural Network Physiology Unit, Laboratory of Systems Neuroscience, and Functional MRI Facility, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 16015 EP - 16020 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 43 SN - 0027-8424, 0027-8424 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Cerebrovascular system KW - Magnetic resonance imaging KW - Tetrodotoxin KW - Cortex KW - N.M.R. KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19359418?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Direct+magnetic+resonance+detection+of+neuronal+electrical+activity&rft.au=Petridou%2C+Natalia%3BPlenz%2C+Dietmar%3BSilva%2C+Afonso+C%3BLoew%2C+Murray%3BBodurka%2C+Jerzy%3BBandettini%2C+Peter+A&rft.aulast=Petridou&rft.aufirst=Natalia&rft.date=2006-10-01&rft.volume=103&rft.issue=43&rft.spage=16015&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; N.M.R.; Neuroimaging; Cerebrovascular system; Cortex; Tetrodotoxin ER - TY - JOUR T1 - Associations of Adiposity with Measured and Self-Reported Academic Performance in Early Adolescence AN - 19356112; 7125837 AB - OBJECTIVE: To examine the associations of adiposity with measured and self-reported academic performance independently of demographics and physical activity among U.S. adolescents. RESEARCH METHODS AND PROCEDURES: We surveyed 666 students 11 to 14 years old from seven middle schools in Los Angeles, CA. Weight and height were measured. Actual grade point average was obtained from school records. Self-reported school grades and physical activity time were measured by questionnaire. Adiposity measures included BMI, BMI percentile ( greater than or equal to 85th percentile defined as at-risk-of-overweight), and percentage body fat (bioimpedance). RESULTS: After adjusting for gender, ethnicity, age, and physical activity time, overweight at-risk status, BMI, and percentage body fat were negatively related to only self-reported (p < 0.01) but not measured grades. Level of moderate-to-vigorous physical activity time was negatively related to measured and self-reported grades, independently of adiposity (p < 0.01). DISCUSSION: To our knowledge, this is the first study to examine both body mass and body fat in relation to measured and self-reported school grades. Adiposity did not relate to actual academic performance in a sample of predominantly Latino and Asian-American adolescents. The use of measured vs. self-reported academic outcomes may represent different constructs and influence study conclusions. Cultural factors may also play a role in our findings, but this requires further study. JF - Obesity Research AU - Huang, Terry T-K AU - Goran, Michael I AU - Spruijt-Metz, Donna AD - Endocrinology, Nutrition, and Growth Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Institute for Health Promotion and Disease Prevention Research, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 1839 EP - 1845 PB - North American Association for the Study of Obesity, 1090 Amsterdam Ave., Ste. 14K New York NY 10025 USA, [mailto:helener@mindspring.com], [URL:http://www.naaso.org] VL - 14 IS - 10 SN - 1071-7323, 1071-7323 KW - Physical Education Index KW - Obesity KW - Measurement KW - Body mass KW - Adolescence KW - Surveys KW - Height KW - Exercise KW - Students KW - Demographics KW - Knowledge KW - Grading KW - Weight KW - Gender KW - Performance KW - Junior high schools KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19356112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Obesity+Research&rft.atitle=Associations+of+Adiposity+with+Measured+and+Self-Reported+Academic+Performance+in+Early+Adolescence&rft.au=Huang%2C+Terry+T-K%3BGoran%2C+Michael+I%3BSpruijt-Metz%2C+Donna&rft.aulast=Huang&rft.aufirst=Terry&rft.date=2006-10-01&rft.volume=14&rft.issue=10&rft.spage=1839&rft.isbn=&rft.btitle=&rft.title=Obesity+Research&rft.issn=10717323&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Adolescence; Body mass; Height; Surveys; Exercise; Students; Knowledge; Demographics; Grading; Weight; Gender; Performance; Junior high schools ER - TY - JOUR T1 - Pathophysiology of writers cramp AN - 19343096; 7088760 AB - Writers cramp is a task-specific focal hand dystonia. The abnormality of task specificity is a curious one and indicates that we need to learn more about the coupling of motor programs and their effectors. Writers cramp appears to be triggered by spending much time writing by an individual with a fertile physiological substrate for producing the disorder. The fertile background, which is likely genetic, may be a decrease of inhibition, an increase of plasticity or an impairment in sensory function. Recent pathophysiological findings have implications for new therapies. JF - Human Movement Science AU - Hallett, Mark AD - Human Motor Control Section, NINDS, NIH Building 10, Room 5N226 Bethesda, MD 20892-1428, USA, hallettm@ninds.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 454 EP - 463 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 25 IS - 4-5 SN - 0167-9457, 0167-9457 KW - Physical Education Index; CSA Neurosciences Abstracts KW - Hand KW - Motor control KW - Neuroimaging KW - Plasticity KW - Sensorimotor KW - Hands KW - Genetics KW - Writing KW - Physiology KW - Therapy KW - Dystonia KW - Cramps KW - Movement KW - PE 100:Kinesiology KW - N3 11029:Neurophysiology & biophysics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19343096?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Movement+Science&rft.atitle=Pathophysiology+of+writers+cramp&rft.au=Hallett%2C+Mark&rft.aulast=Hallett&rft.aufirst=Mark&rft.date=2006-10-01&rft.volume=25&rft.issue=4-5&rft.spage=454&rft.isbn=&rft.btitle=&rft.title=Human+Movement+Science&rft.issn=01679457&rft_id=info:doi/10.1016%2Fj.humov.2006.05.004 LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hands; Genetics; Writing; Physiology; Therapy; Cramps; Movement; Hand; Dystonia; Plasticity DO - http://dx.doi.org/10.1016/j.humov.2006.05.004 ER - TY - JOUR T1 - Evolutionary systems biology: links between gene evolution and function AN - 19337482; 7078364 AB - The recent accumulation of genome-wide data on various facets of gene expression, function and evolution stimulated the emergence of a new field, evolutionary systems biology. Many significant correlations were detected between variables that characterize the functioning of a gene, such as expression level, knockout effect, connectivity of genetic and protein-protein interaction networks, and variables that describe gene evolution, such as sequence evolution rate and propensity for gene loss. The first attempts on multidimensional analysis of genomic data yielded composite variables that describe the status of a gene in the genomic community. However, it remains uncertain whether different functional variables affect gene evolution synergistically or there is a single, dominant factor. The number of translation events, linked to selection for translational robustness, was proposed as a candidate for such a major determinant of protein evolution. These developments show that, although the methodological basis of evolutionary systems biology is not yet fully solidified, this area of research is already starting to yield fundamental biological insights. JF - Current Opinion in Biotechnology AU - Koonin, Eugene V AU - Wolf, Yuri I AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA, koonin@ncbi.nlm.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 481 EP - 487 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 5 SN - 0958-1669, 0958-1669 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gene expression KW - Translation KW - Data processing KW - Reviews KW - Evolutionary genetics KW - genomics KW - Protein interaction KW - G 07740:Evolution KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19337482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Evolutionary+systems+biology%3A+links+between+gene+evolution+and+function&rft.au=Koonin%2C+Eugene+V%3BWolf%2C+Yuri+I&rft.aulast=Koonin&rft.aufirst=Eugene&rft.date=2006-10-01&rft.volume=17&rft.issue=5&rft.spage=481&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.08.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Translation; Data processing; Reviews; genomics; Evolutionary genetics; Protein interaction DO - http://dx.doi.org/10.1016/j.copbio.2006.08.003 ER - TY - JOUR T1 - Modes of Regulation of RpoS by H-NS AN - 19331375; 7061573 AB - Regulated degradation of RpoS requires RssB and ClpXP protease. Mutations in hns increase both RpoS synthesis and stability, causing a twofold increase in synthesis and almost complete stabilization of RpoS, independent of effects on synthesis and independent of phosphorylation of RssB. This suggests that H-NS regulates an RssB inhibitor or inhibitors. JF - Journal of Bacteriology AU - Zhou, YanNing AU - Gottesman, Susan AD - Laboratory of Molecular Biology, National Cancer Institute, Bethesda, Maryland 20892 Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 7022 EP - 7025 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 19 SN - 0021-9193, 0021-9193 KW - RpoS protein KW - RssB protein KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Biodegradation KW - Phosphorylation KW - Proteinase KW - Mutation KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19331375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Modes+of+Regulation+of+RpoS+by+H-NS&rft.au=Zhou%2C+YanNing%3BGottesman%2C+Susan&rft.aulast=Zhou&rft.aufirst=YanNing&rft.date=2006-10-01&rft.volume=188&rft.issue=19&rft.spage=7022&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Biodegradation; Phosphorylation; Proteinase; Mutation ER - TY - JOUR T1 - Serum concentrations of estrogens, sex hormone-binding globulin, and androgens and risk of breast cancer in postmenopausal women AN - 19330449; 7074582 AB - We assessed the relationship between serum concentrations of estrogens, androgens, and sex hormone-binding globulin and risk of breast cancer among postmenopausal women. Study participants provided serum prior to breast biopsy or mastectomy in 3 hospitals in Grand Rapids, Michigan between 1977 and 1987. A total of 179 subjects with localized breast cancer were compared to 152 subjects with nonproliferative breast changes that have not been associated with elevated breast cancer risk. Increasing serum concentrations of estrone and estrone sulfate were associated with increases in breast cancer risk; the odds ratios (ORs) in the fourth quartiles compared to the first were 2.3 (95% confidence interval (CI) 1.1-4.6) for both (p-trend = 0.02 and 0.03, respectively). Estradiol and bioavailable estradiol concentrations were associated with nonstatistically significant increases in risk. Androstenediol levels were associated with risk (p-trend = 0.01); the OR in the fourth compared to the first quartile was 2.2 (95% CI 1.0-4.6). Testosterone, dehydroepiandrosterone and androstenedione levels were not associated with increased risk. Sex hormone- binding globulin was associated with a nonsignificant decrease in risk. Associations with estrone and estrone sulfate persisted after adjustment for androstenediol (ORs for fourth compared to first quartiles were 2.0 (95% CI 0.9- 4.5) and 2.2 (95% CI 1.0-4.6), respectively (p-trend = 0.16 for both). The association with androstenediol was attenuated after adjustment for estrone (OR for fourth compared to first quartile was 1.6 (95% CI 0.7-3.6); p-trend = 0.13). Higher serum concentrations of estrogens were associated with increased breast cancer risk in postmenopausal women. Androgen levels were not independently associated with substantially increased risk. JF - International Journal of Cancer AU - Adly, Laila AU - Hill, Deirdre AU - Sherman, Mark E AU - Sturgeon, Susan R AU - Fears, Thomas AU - Mies, Carolyn AU - Ziegler, Regina G AU - Hoover, Robert N AU - Schairer, Catherine AD - George Washington University, Department of Epidemiology and Biostatistics, School of Public Health and Health Services, Washington, D.C., schairec@exchange.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2402 EP - 2407 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts KW - breast cancer KW - estrogens KW - androgens KW - androstenediol KW - Bioavailability KW - post-menopause KW - Breast cancer KW - Females KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19330449?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Serum+concentrations+of+estrogens%2C+sex+hormone-binding+globulin%2C+and+androgens+and+risk+of+breast+cancer+in+postmenopausal+women&rft.au=Adly%2C+Laila%3BHill%2C+Deirdre%3BSherman%2C+Mark+E%3BSturgeon%2C+Susan+R%3BFears%2C+Thomas%3BMies%2C+Carolyn%3BZiegler%2C+Regina+G%3BHoover%2C+Robert+N%3BSchairer%2C+Catherine&rft.aulast=Adly&rft.aufirst=Laila&rft.date=2006-10-01&rft.volume=119&rft.issue=10&rft.spage=2402&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22203 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Bioavailability; post-menopause; Breast cancer; Females; Cancer; estrogens DO - http://dx.doi.org/10.1002/ijc.22203 ER - TY - JOUR T1 - Reproductive factors, exogenous hormone use and bladder cancer risk in a prospective study AN - 19329081; 7074581 AB - Sex is a consistent predictor of bladder cancer: men experience 2-4-fold higher age-adjusted rates than women in the U.S. and Europe. The objective of this study was to examine whether hormone-related factors are associated with bladder cancer in women. We examined parity, age at menarche, age at first birth, age at menopause, oral contraceptive use and menopausal hormone therapy (HT) use and bladder cancer risk in the Breast Cancer Detection Demonstration Project Follow-Up Study. Endpoint and exposure information was collected on 54,308 women, using annual telephone interviews (1980-86) and 3 mailed, self- administered questionnaires (1987-98). During an average follow-up time of 15.3 years, 167 cases of bladder cancer were identified. Univariate and adjusted rate ratios (RRs) were estimated using Poisson regression. Parity, age at menarche, age at first birth, age at menopause, and oral contraceptive use were not associated with bladder cancer risk. The majority of menopausal women who took HT used estrogen therapy (ET). Postmenopausal women with less than 4 years, 4-9 years, 10-19 years and 20 or more years of ET use had RRs of 1.55 (95% CI = 0.96-2.51), 1.00 (95% CI = 0.49-2.04), 1.23 (95% CI = 0.62-2.43) and 0.57 (95% CI = 0.14-2.34), respectively, compared with nonusers (p = 0.50). Findings from this study are not consistent with the hypothesis that hormone-related factors in women are associated with bladder cancer. JF - International Journal of Cancer AU - Cantwell, Marie M AU - Lacey Jr, James V AU - Schairer, Catherine AU - Schatzkin, Arthur AU - Michaud, Dominique S AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, m.cantwell@qub.ac.uk Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2398 EP - 2401 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 10 SN - 0020-7136, 0020-7136 KW - urinary bladder KW - Risk Abstracts KW - bladder cancer KW - hormone therapy KW - reproductive factors KW - estrogen KW - parity KW - age at menarche KW - menopause KW - USA KW - post-menopause KW - Breast cancer KW - Europe KW - Hormones KW - Cancer KW - contraceptives KW - estrogens KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19329081?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Reproductive+factors%2C+exogenous+hormone+use+and+bladder+cancer+risk+in+a+prospective+study&rft.au=Cantwell%2C+Marie+M%3BLacey+Jr%2C+James+V%3BSchairer%2C+Catherine%3BSchatzkin%2C+Arthur%3BMichaud%2C+Dominique+S&rft.aulast=Cantwell&rft.aufirst=Marie&rft.date=2006-10-01&rft.volume=119&rft.issue=10&rft.spage=2398&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22175 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - post-menopause; menopause; Breast cancer; Hormones; Cancer; estrogens; contraceptives; USA; Europe DO - http://dx.doi.org/10.1002/ijc.22175 ER - TY - JOUR T1 - Lung cancer risk among US radiologic technologists, 1983-1998 AN - 19328320; 7074594 AB - While exposure to moderate to high-dose ionizing radiation is an established risk factor for lung cancer, the relationship between lung cancer and chronic low dose radiation remains uncertain. We examined lung cancer risk among 71,894 US radiologic technologists who were certified during 1926-1982, responded to a baseline questionnaire (1983-1989), and were free of cancer other than non- melanoma skin cancer at baseline. Study participants were followed until completion of a second questionnaire (1994-1998), death, or August 31, 1998. We identified 287 lung cancer cases: 66 incident cases and 221 decedents. Exposure to radiation was inferred based on work history information provided in the baseline questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazard models adjusted for age, race/ethnicity and smoking. Smoking-adjusted lung cancer risk was not related to working as a radiologic technologist in early years when radiation exposures were likely highest (RR = 0.9; 95% CI, 0.5-1.8 for year first worked before 1940 compared to year first worked >1960), nor was risk related to the year first worked after 1940 or the number of years worked in any decade. While lung cancer risk was increased in radiologic technologists who held patients for X-rays, or who allowed others to take numerous practice X-rays on them, the trend was not statistically significant in either case. Although we adjusted for smoking, the possibility of residual confounding exists. Overall, we find very limited evidence that chronic low-to-moderate dose occupational exposure increased lung cancer risk in the US Radiologic Technologist cohort. JF - International Journal of Cancer AU - Rajaraman, Preetha AU - Sigurdson, Alice J AU - Doody, Michele M AU - Freedman, DMichal AU - Hauptmann, Michael AU - Ron, Elaine AU - Alexander, Bruce H AU - Linet, Martha S AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, rajarama@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 2481 EP - 2486 PB - John Wiley & Sons, Inc., 111 River Street Hoboken NJ 07030 USA, [mailto:custserv@wiley.com], [URL:http://www.wiley.com/] VL - 119 IS - 10 SN - 0020-7136, 0020-7136 KW - Risk Abstracts; Health & Safety Science Abstracts KW - lung cancer KW - cohort KW - occupation KW - radiation KW - risk factors KW - radiologic technologist KW - Smoking KW - Mortality KW - Historical account KW - USA KW - Skin KW - Ionizing radiation KW - Medical personnel KW - Occupational exposure KW - Ethnic groups KW - Lung cancer KW - R2 23080:Industrial and labor KW - H 8000:Radiation Safety/Electrical Safety UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19328320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Cancer&rft.atitle=Lung+cancer+risk+among+US+radiologic+technologists%2C+1983-1998&rft.au=Rajaraman%2C+Preetha%3BSigurdson%2C+Alice+J%3BDoody%2C+Michele+M%3BFreedman%2C+DMichal%3BHauptmann%2C+Michael%3BRon%2C+Elaine%3BAlexander%2C+Bruce+H%3BLinet%2C+Martha+S&rft.aulast=Rajaraman&rft.aufirst=Preetha&rft.date=2006-10-01&rft.volume=119&rft.issue=10&rft.spage=2481&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Cancer&rft.issn=00207136&rft_id=info:doi/10.1002%2Fijc.22148 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Historical account; Mortality; Smoking; Skin; Ionizing radiation; Ethnic groups; Occupational exposure; Medical personnel; Lung cancer; USA DO - http://dx.doi.org/10.1002/ijc.22148 ER - TY - JOUR T1 - Large-amplitude, spatially correlated fluctuations in BOLD fMRI signals during extended rest and early sleep stages AN - 19323974; 7072356 AB - A number of recent studies of human brain activity using blood-oxygen-level- dependent (BOLD) fMRI and EEG have reported the presence of spatiotemporal patterns of correlated activity in the absence of external stimuli. Although these patterns have been hypothesized to contain important information about brain architecture, little is known about their origin or about their relationship to active cognitive processes such as conscious awareness and monitoring of the environment. In this study, we have investigated the amplitude and spatiotemporal characteristics of resting-state activity patterns and their dependence on the subjects alertness. For this purpose, BOLD fMRI was performed at 3.0 T on 12 normal subjects using a visual stimulation protocol, followed by a 27 min rest period, during which subjects were allowed to fall asleep. In subjects who were asleep at the end of the scan, we found (a) a higher amplitude of BOLD signal fluctuation during rest compared with subjects who were awake at the end of the scan; (b) spatially independent patterns of correlated activity that involve all of gray matter, including deep brain nuclei; (c) many patterns that were consistent across subjects; (d) that average percentage levels of fluctuation in visual cortex (VC) and whole brain were higher in subjects who were asleep (up to 1.71% and 1.16%, respectively) than in those who were awake (up to 1.15% and 0.96%) at the end of the scan and were comparable with those levels evoked by intense visual stimulation (up to 1.85% and 0.76% for two subject groups); (e) no confirmation of correlation, positive or negative, between thalamus and VC found in earlier studies. These findings suggest that resting-state activity continues during sleep and does not require active cognitive processes or conscious awareness. JF - Magnetic Resonance Imaging AU - Fukunaga, Masaki AU - Horovitz, Silvina G AU - Van Gelderen, Peter AU - De Zwart, Jacco A AU - Jansma, JMartijn AU - Ikonomidou, Vasiliki N AU - Chu, Renxin AU - Deckers, Roel HR AU - Leopold, David A AU - Duyn, Jeff H AD - Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, MD 20892-1065, USA, fukunagm@mail.nih.gov Y1 - 2006/10// PY - 2006 DA - Oct 2006 SP - 979 EP - 992 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 24 IS - 8 SN - 0730-725X, 0730-725X KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Functional magnetic resonance imaging KW - External stimuli KW - Thalamus KW - Visual stimuli KW - Cortex (visual) KW - Cognitive ability KW - Sleep KW - EEG KW - Activity patterns KW - Brain architecture KW - Substantia grisea KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19323974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+Imaging&rft.atitle=Large-amplitude%2C+spatially+correlated+fluctuations+in+BOLD+fMRI+signals+during+extended+rest+and+early+sleep+stages&rft.au=Fukunaga%2C+Masaki%3BHorovitz%2C+Silvina+G%3BVan+Gelderen%2C+Peter%3BDe+Zwart%2C+Jacco+A%3BJansma%2C+JMartijn%3BIkonomidou%2C+Vasiliki+N%3BChu%2C+Renxin%3BDeckers%2C+Roel+HR%3BLeopold%2C+David+A%3BDuyn%2C+Jeff+H&rft.aulast=Fukunaga&rft.aufirst=Masaki&rft.date=2006-10-01&rft.volume=24&rft.issue=8&rft.spage=979&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+Imaging&rft.issn=0730725X&rft_id=info:doi/10.1016%2Fj.mri.2006.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Functional magnetic resonance imaging; Visual stimuli; Cognitive ability; Sleep; Cortex (visual); Activity patterns; Substantia grisea; Thalamus; External stimuli; EEG; Brain architecture DO - http://dx.doi.org/10.1016/j.mri.2006.04.018 ER - TY - JOUR T1 - Role of an RNase III Binding Site in Transcription Termination at lambda nutL by HK022 Nun Protein AN - 19322175; 7061553 AB - The phage HK022 Nun protein excludes phage lambda by binding nascent lambda p sub(L) and p sub(R) transcripts at nutL and nutR, respectively, and inducing transcription termination just downstream of these sites. Termination is more efficient at nutL than at nutR. One difference between nutL and nutR is the presence of RNase III processing sites (rIII) located immediately promoter distal to lambda nutL. We found that deletion of rIII dramatically reduced Nun transcription arrest in vitro but had little effect on termination in vivo. However, consistent with the in vitro results, overexpression of a transcript carrying nutL and rIII efficiently titrated Nun, allowing lambda to grow on a strain that expressed Nun, whereas a transcript carrying only nutL or nutL-rIII with nucleotides 97 to 141 deleted was ineffective. Rnc70, an RNase III mutant that binds but does not cleave rIII, also prevented Nun-mediated lambda exclusion. We propose that rIII enhances the on-rate of Nun at nutL, stimulating Nun-mediated arrest in vitro. We have shown that a specific element in rIII, i.e., box C (G sub(89)GUGUGUG), strongly enhances arrest on rIII super(+) templates. Nun-rIII interactions do not stimulate Nun termination in vivo, presumably because formation of the Nun-nutL complex is normally not rate-limiting in the cell. In contrast to Nun, N is not occluded by Rnc70 and is not efficiently titrated by a nutL-rIII transcript. JF - Journal of Bacteriology AU - Washburn, Robert S AU - Court, Donald L AU - Gottesman, Max E AD - Department of Microbiology and Institute of Cancer Research, Columbia University Medical Center, New York, New York 10032. Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology, National Cancer Institute, National Institutes of Health, Frederick, Maryland 21702-1202 Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 6824 EP - 6831 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 19 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - Promoters KW - Deletion KW - Transcription termination KW - Phage HK022 KW - Ribonuclease III KW - Phage l KW - Nucleotides KW - N 14835:Protein-Nucleic Acids Association KW - J 02430:Symbiosis, Antibiosis & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19322175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Role+of+an+RNase+III+Binding+Site+in+Transcription+Termination+at+lambda+nutL+by+HK022+Nun+Protein&rft.au=Washburn%2C+Robert+S%3BCourt%2C+Donald+L%3BGottesman%2C+Max+E&rft.aulast=Washburn&rft.aufirst=Robert&rft.date=2006-10-01&rft.volume=188&rft.issue=19&rft.spage=6824&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Promoters; Deletion; Transcription termination; Ribonuclease III; Nucleotides; Phage HK022; Phage l ER - TY - JOUR T1 - A Prospective Study of Anthropometric and Clinical Measurements Associated with Insulin Resistance Syndrome and Colorectal Cancer in Male Smokers AN - 19318389; 7057635 AB - Type 2 diabetes mellitus shares risk factors for and has shown a positive association with colorectal cancer. Anthropometric measures (height, weight, and body mass index (weight (kg)/height (m) super(2)) and metabolic abnormalities associated with insulin resistance syndrome (IRS) (abnormalities in measured blood pressure, high density lipoprotein (HDL) cholesterol, and total cholesterol) were prospectively evaluated for associations with incident colon (n = 227), rectal (n = 183), and colorectal (n = 410) cancers diagnosed between 1985 and 2002 in 28,983 Finnish male smokers from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Cox proportional hazards models were used to calculate hazard ratios and 95% confidence intervals. In comparison with the lowest quintile, the highest quintile of body mass index was significantly associated with colorectal cancer (hazard ratio (HR) = 1.70, 95% confidence interval (CI): 1.01, 2.85; p-trend = 0.01), particularly colon cancer. Subjects with a cluster of three IRS-related conditions (hypertension, body mass index greater than or equal to 25 kg/m super(2), and HDL cholesterol level <40 mg/dl (<1.55 mmol/liter)), compared with those with fewer conditions, had a significantly increased risk of colorectal cancer (HR = 1.40, 95% CI: 1.12, 1.74), particularly colon cancer (HR = 1.58, 95% CI: 1.18, 2.10), but not rectal cancer. These results support the hypothesis that the significant association observed between IRS-defining metabolic abnormalities and colorectal cancer is determined primarily by adiposity. JF - American Journal of Epidemiology AU - Bowers, Katherine AU - Albanes, Demetrius AU - Limburg, Paul AU - Pietinen, Pirjo AU - Taylor, Phil R AU - Virtamo, Jarmo AU - Stolzenberg-Solomon, Rachael AD - Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD Y1 - 2006/10/01/ PY - 2006 DA - 2006 Oct 01 SP - 652 EP - 664 PB - Oxford University Press, Oxford Journals Health, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 164 IS - 7 SN - 0002-9262, 0002-9262 KW - Toxicology Abstracts KW - Rectum KW - Lipoproteins (high density) KW - Colorectal cancer KW - Colon cancer KW - Cholesterol KW - Blood pressure KW - Insulin KW - Models KW - Diabetes mellitus KW - Risk factors KW - Adipose tissue KW - Body mass index KW - Hypertension KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19318389?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Epidemiology&rft.atitle=A+Prospective+Study+of+Anthropometric+and+Clinical+Measurements+Associated+with+Insulin+Resistance+Syndrome+and+Colorectal+Cancer+in+Male+Smokers&rft.au=Bowers%2C+Katherine%3BAlbanes%2C+Demetrius%3BLimburg%2C+Paul%3BPietinen%2C+Pirjo%3BTaylor%2C+Phil+R%3BVirtamo%2C+Jarmo%3BStolzenberg-Solomon%2C+Rachael&rft.aulast=Bowers&rft.aufirst=Katherine&rft.date=2006-10-01&rft.volume=164&rft.issue=7&rft.spage=652&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Rectum; Lipoproteins (high density); Colorectal cancer; Cholesterol; Colon cancer; Insulin; Blood pressure; Models; Diabetes mellitus; Risk factors; Adipose tissue; Body mass index; Hypertension ER - TY - JOUR T1 - The pathogenesis of Newcastle disease: a comparison of selected Newcastle disease virus wild-type strains and their infectious clones. AN - 68889971; 16860365 AB - The effect of mutations of Newcastle disease virus (NDV) fusion (F) gene, hemagglutinin-neuraminidase (HN) gene, and phosphoprotein (P) gene and HN chimeras between the virulent Beaudette C and low virulence LaSota strains on pathogenesis and pathogenicity was examined in fully susceptible chickens. A virulent F cleavage site motif within a LaSota backbone increased pathogenicity and severity of clinical disease. A LaSota HN within a Beaudette C backbone decreased pathogenicity indices and disease severity. A Beaudette C HN within a LaSota backbone did not change either pathogenicity indices or severity of disease in chickens. Loss of glycosylation at site 4 of the HN or modified P gene of Beaudette C decreased pathogenicity indices and caused no overt clinicopathologic disease in chickens. Both pathogenicity indices and clinicopathologic examination demonstrated that the F, HN, and P genes of NDV collectively or individually can contribute to viral virulence. JF - Virology AU - Wakamatsu, Nobuko AU - King, Daniel J AU - Seal, Bruce S AU - Samal, Siba K AU - Brown, Corrie C AD - Department of Veterinary Pathology, College of Veterinary Medicine, University of Georgia, GA 30605, USA. wakamatsun@niehs.nih.gov Y1 - 2006/09/30/ PY - 2006 DA - 2006 Sep 30 SP - 333 EP - 343 VL - 353 IS - 2 SN - 0042-6822, 0042-6822 KW - HN Protein KW - 0 KW - P phosphoprotein, Newcastle disease virus KW - Phosphoproteins KW - Viral Fusion Proteins KW - Viral Proteins KW - Index Medicus KW - Virulence KW - Viral Proteins -- genetics KW - Mutagenesis, Site-Directed KW - HN Protein -- genetics KW - Animals KW - Chickens KW - Phosphoproteins -- genetics KW - Chick Embryo KW - Viral Fusion Proteins -- genetics KW - Newcastle disease virus -- pathogenicity KW - Newcastle Disease -- virology KW - Newcastle disease virus -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68889971?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=The+pathogenesis+of+Newcastle+disease%3A+a+comparison+of+selected+Newcastle+disease+virus+wild-type+strains+and+their+infectious+clones.&rft.au=Wakamatsu%2C+Nobuko%3BKing%2C+Daniel+J%3BSeal%2C+Bruce+S%3BSamal%2C+Siba+K%3BBrown%2C+Corrie+C&rft.aulast=Wakamatsu&rft.aufirst=Nobuko&rft.date=2006-09-30&rft.volume=353&rft.issue=2&rft.spage=333&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Metabolic Super Scan in Patients with Hyperthyroidism: Does it have a Clinical Significance? T2 - 19th Annual Congress of the European Association of Nuclear Medicine (EANM 06) AN - 40314217; 4400020 JF - 19th Annual Congress of the European Association of Nuclear Medicine (EANM 06) AU - Kotb, M H AU - El-Maghraby, T A F AU - Allah, K. M. E. Khalaf Y1 - 2006/09/30/ PY - 2006 DA - 2006 Sep 30 KW - Hyperthyroidism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40314217?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=19th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+06%29&rft.atitle=Metabolic+Super+Scan+in+Patients+with+Hyperthyroidism%3A+Does+it+have+a+Clinical+Significance%3F&rft.au=Kotb%2C+M+H%3BEl-Maghraby%2C+T+A+F%3BAllah%2C+K.+M.+E.+Khalaf&rft.aulast=Kotb&rft.aufirst=M&rft.date=2006-09-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=19th+Annual+Congress+of+the+European+Association+of+Nuclear+Medicine+%28EANM+06%29&rft.issn=&rft_id=info:doi/ L2 - http://eanm06.eanm.org/abstracts/abstract_search.php?PHPSESSID=79b1536 1a2c0f0d234f935781798991a&navigationId=65 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Targeted optical imaging of cancer cells using lectin-binding BODIPY conjugated avidin AN - 19458739; 7084513 AB - Lectins (asialo-receptor family) are expressed on a number of tumors that develop peritoneal metastases. To demonstrate that fluorescence imaging based on lectin binding is applicable for a variety of tumors, we conjugated BODIPY to avidin (avidin-BODIPY), and studied the efficacy of tumor targeting in 9 cancer cell lines in vitro and an ovarian cancer cell line in vivo using a murine peritoneal cancer model. All 9 cell lines showed specific intracellular accumulation with avidin-BODIPY on fluorescence microscopy and flow cytometry. In vivo spectral molecular imaging clearly visualized the peritoneal tumor foci with avidin-BODIPY, whereas, deglycosylated avidin-BODIPY (neutravidin-BODIPY) showed only minimal fluorescence from the tumor foci and was accompanied by higher background signals. These results suggest the lectin-targeted molecular imaging technique using a targeted green fluorescence probe is potentially useful in a wide variety of cancers with a proclivity for dissemination in the peritoneal space. JF - Biochemical and Biophysical Research Communications AU - Hama, Y AU - Urano, Y AU - Koyama, Y AU - Choyke, P L AU - Kobayashi, H AD - Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA, Kobayash@mail.nih.gov Y1 - 2006/09/29/ PY - 2006 DA - 2006 Sep 29 SP - 807 EP - 813 PB - Elsevier Inc. VL - 348 IS - 3 SN - 0006-291X, 0006-291X KW - Biotechnology and Bioengineering Abstracts KW - Ovarian cancer KW - Fluorescence KW - Peritoneum KW - Animal models KW - Lectins KW - Tumors KW - imaging KW - Metastases KW - Flow cytometry KW - Avidin KW - Tumor cell lines KW - Fluorescent indicators KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458739?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Targeted+optical+imaging+of+cancer+cells+using+lectin-binding+BODIPY+conjugated+avidin&rft.au=Hama%2C+Y%3BUrano%2C+Y%3BKoyama%2C+Y%3BChoyke%2C+P+L%3BKobayashi%2C+H&rft.aulast=Hama&rft.aufirst=Y&rft.date=2006-09-29&rft.volume=348&rft.issue=3&rft.spage=807&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2006.07.169 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; imaging; Fluorescence; Peritoneum; Tumor cell lines; Avidin; Lectins; Fluorescent indicators; Flow cytometry; Animal models; Ovarian cancer; Metastases DO - http://dx.doi.org/10.1016/j.bbrc.2006.07.169 ER - TY - JOUR T1 - Suppression of replication fork progression in low-dose-specific p53-dependent S-phase DNA damage checkpoint. AN - 68903220; 16682953 AB - The S-phase DNA damage checkpoint is activated by DNA damage to delay DNA synthesis allowing time to resolve the replication block. We previously discovered the p53-dependent S-phase DNA damage checkpoint in mouse zygotes fertilized with irradiated sperm. Here, we report that the same p53 dependency holds in mouse embryonic fibroblasts (MEFs) at low doses of irradiation. DNA synthesis in p53 wild-type (WT) MEFs was suppressed in a biphasic manner in which a sharp decrease below 2.5 Gy was followed by a more moderate decrease up to 10 Gy. In contrast, p53-/- MEFs exhibited radioresistant DNA synthesis below 2.5 Gy whereas the cells retained the moderate suppression above 5 Gy. DNA fiber analysis revealed that 1 Gy irradiation suppressed replication fork progression in p53 WT MEFs, but not in p53-/- MEFs. Proliferating cell nuclear antigen (PCNA), clamp loader of DNA polymerase, was phosphorylated in WT MEFs after 1 Gy irradiation and redistributed to form foci in the nuclei. In contrast, PCNA was not phosphorylated and dissociated from chromatin in 1 Gy-irradiated p53-/- MEFs. These results demonstrate that the novel low-dose-specific p53-dependent S-phase DNA damage checkpoint is likely to regulate the replication fork movement through phosphorylation of PCNA. JF - Oncogene AU - Shimura, T AU - Toyoshima, M AU - Adiga, S K AU - Kunoh, T AU - Nagai, H AU - Shimizu, N AU - Inoue, M AU - Niwa, O AD - Department of Late Effect Studies, Radiation Biology Center, Kyoto University, Sakyo-ku, Kyoto, Japan. shimurat@mail.nih.gov Y1 - 2006/09/28/ PY - 2006 DA - 2006 Sep 28 SP - 5921 EP - 5932 VL - 25 IS - 44 SN - 0950-9232, 0950-9232 KW - Proliferating Cell Nuclear Antigen KW - 0 KW - Tumor Suppressor Protein p53 KW - Index Medicus KW - Animals KW - Mice, Inbred ICR KW - Phosphorylation KW - Gamma Rays KW - Humans KW - Mice KW - Dose-Response Relationship, Radiation KW - Cell Line, Transformed KW - Proliferating Cell Nuclear Antigen -- metabolism KW - Mice, Knockout KW - Fibroblasts -- physiology KW - DNA Repair -- genetics KW - Tumor Suppressor Protein p53 -- physiology KW - S Phase -- genetics KW - DNA Damage -- genetics KW - DNA Replication UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68903220?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Suppression+of+replication+fork+progression+in+low-dose-specific+p53-dependent+S-phase+DNA+damage+checkpoint.&rft.au=Shimura%2C+T%3BToyoshima%2C+M%3BAdiga%2C+S+K%3BKunoh%2C+T%3BNagai%2C+H%3BShimizu%2C+N%3BInoue%2C+M%3BNiwa%2C+O&rft.aulast=Shimura&rft.aufirst=T&rft.date=2006-09-28&rft.volume=25&rft.issue=44&rft.spage=5921&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-03 N1 - Date created - 2006-09-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental genotoxicants/carcinogens and childhood cancer: bridgeable gaps in scientific knowledge. AN - 68852845; 16829162 AB - Cancer in children is a major concern in many countries. An important question is whether these childhood cancers are caused by something, or are just tragic random events. Causation of at least some children's cancers is suggested by direct and indirect evidence, including epidemiological data, and animal studies that predict early life sensitivity of humans to carcinogenic effects. Candidate risk factors include genotoxic agents (chemicals and radiation), but also diet/nutrition, and infectious agents/immune responses. With regard to likelihood of risks posed by genotoxicants, there are pros and cons. The biological properties of fetuses and infants are consistent with sensitivity to preneoplastic genotoxic damage. Recent studies of genetic polymorphisms in carcinogen-metabolizing enzymes confirm a role for chemicals. On the other hand, in numerous epidemiological studies, associations between childhood cancers and exposure to genotoxicants, including tobacco smoke, have been weak and hard to reproduce. Possibly, sensitive genetic or ontogenetic subpopulations, and/or co-exposure situations need to be discovered to allow identification of susceptible individuals and their risk factors. Among the critical knowledge gaps needing to be bridged to aid in this effort include detailed tissue and cellular ontogeny of carcinogen metabolism and DNA repair enzymes, and associations of polymorphisms in DNA repair enzymes with childhood cancers. Perinatal bioassays in animals of specific environmental candidates, for example, benzene, could help guide epidemiology. Genetically engineered animal models could be useful for identification of chemical effects on specific genes. Investigations of interactions between factors may be key to understanding risk. Finally, fathers and newborn infants should receive more attention as especially sensitive targets. JF - Mutation research AU - Anderson, Lucy M AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Andersol@mail.ncifcrf.gov Y1 - 2006/09/28/ PY - 2006 DA - 2006 Sep 28 SP - 136 EP - 156 VL - 608 IS - 2 SN - 0027-5107, 0027-5107 KW - Carcinogens, Environmental KW - 0 KW - Mutagens KW - DNA Repair Enzymes KW - EC 6.5.1.- KW - Index Medicus KW - DNA Repair Enzymes -- metabolism KW - Models, Animal KW - Animals KW - Polymorphism, Single Nucleotide KW - Epidemiologic Factors KW - Humans KW - Infant, Newborn KW - Child KW - Mice KW - Pregnancy KW - DNA Repair Enzymes -- genetics KW - Risk Factors KW - Female KW - Male KW - Neoplasms -- chemically induced KW - Neoplasms -- epidemiology KW - Carcinogens, Environmental -- metabolism KW - Mutagens -- toxicity KW - Carcinogens, Environmental -- toxicity KW - Neoplasms -- genetics KW - Neoplasms -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68852845?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Mutation+research&rft.atitle=Environmental+genotoxicants%2Fcarcinogens+and+childhood+cancer%3A+bridgeable+gaps+in+scientific+knowledge.&rft.au=Anderson%2C+Lucy+M&rft.aulast=Anderson&rft.aufirst=Lucy&rft.date=2006-09-28&rft.volume=608&rft.issue=2&rft.spage=136&rft.isbn=&rft.btitle=&rft.title=Mutation+research&rft.issn=00275107&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Reprint In: Curr Probl Pediatr Adolesc Health Care. 2008 Feb;38(2):50-63 [18237856] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Apoptosis mediated by p53 in rat neural AF5 cells following treatment with hydrogen peroxide and staurosporine. AN - 68859989; 16901471 AB - AF5 neural cells derived from fetal rat mesencephalic tissue were immortalized with a truncated SV40 LT vector lacking the p53-inactivating domain to maintain long-term cultures with a p53-responsive phenotype. This study examined p53 function in producing programmed cell death in propagating AF5 neural cells after exposure to hydrogen peroxide (H2O2) and the kinase inhibitor staurosporine (STSP). Concentration-dependent exposure of AF5 cells to 0-800 mM H2O2 and STSP at 0-1000 nM revealed increasing cytotoxicity from MTS cell viability assays. Apoptosis occurred at 400 mM H2O2 as evidenced by subG1 DNA and Annexin V flow cytometry analyses and cellular immunofluorescence staining with propidium iodide, anti-Annexin V and DAPI. DNA fragmentation, caspase-3/7 activity and cytochrome c release into cytosol also confirmed H2O2-mediated apoptotic events. p53 protein levels were increased over 24 h by H2O2 in a coordinated fashion with mdm2 expression. p53 activation by H2O2 was evidenced by elevated Ser15 phosphorylation, increased luciferase p53 reporter activity and upregulation of the downstream p53 targets p21(waf1) and apoptotic proteins, bax, Noxa and PUMA. STSP exposure produced apoptosis demonstrated by DNA fragmentation, caspase-3/7 activity, cytochrome c release and over 24 h was accompanied by sustained increase in p53 and Ser15 phosphorylation, rise in p21(waf1) and bax and a transient increase in p53 reporter activity but without Annexin V binding. These findings demonstrate that AF5 cells undergo apoptosis in response to H2O2-mediated oxidative stress and signal pathway disruption by STSP that therefore would be useful in studies related to p53-dependent neuronal cell death and neurodegeneration. JF - Brain research AU - McNeill-Blue, Charlesene AU - Wetmore, Barbara A AU - Sanchez, Joseph F AU - Freed, William J AU - Merrick, B Alex AD - Proteomics Group, National Center for Toxicogenomics, National Institute of Environmental Health Sciences, National Institute of Health, Department of Health and Human Services, D2-04, P.O. Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 SP - 1 EP - 15 VL - 1112 IS - 1 SN - 0006-8993, 0006-8993 KW - Annexin A5 KW - 0 KW - Enzyme Inhibitors KW - Nerve Tissue Proteins KW - Oxidants KW - Tumor Suppressor Protein p53 KW - Hydrogen Peroxide KW - BBX060AN9V KW - Caspases KW - EC 3.4.22.- KW - Staurosporine KW - H88EPA0A3N KW - Index Medicus KW - Animals KW - Analysis of Variance KW - Dose-Response Relationship, Drug KW - Fluorescent Antibody Technique -- methods KW - Blotting, Western -- methods KW - Annexin A5 -- metabolism KW - Caspases -- metabolism KW - In Situ Nick-End Labeling -- methods KW - Flow Cytometry -- methods KW - Rats KW - Cell Survival -- drug effects KW - Enzyme Activation -- drug effects KW - Nerve Tissue Proteins -- metabolism KW - Gene Expression Regulation -- drug effects KW - Time Factors KW - Cell Cycle -- drug effects KW - Cell Line KW - Staurosporine -- pharmacology KW - Oxidants -- pharmacology KW - Neurons -- drug effects KW - Hydrogen Peroxide -- pharmacology KW - Apoptosis -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Tumor Suppressor Protein p53 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68859989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+research&rft.atitle=Apoptosis+mediated+by+p53+in+rat+neural+AF5+cells+following+treatment+with+hydrogen+peroxide+and+staurosporine.&rft.au=McNeill-Blue%2C+Charlesene%3BWetmore%2C+Barbara+A%3BSanchez%2C+Joseph+F%3BFreed%2C+William+J%3BMerrick%2C+B+Alex&rft.aulast=McNeill-Blue&rft.aufirst=Charlesene&rft.date=2006-09-27&rft.volume=1112&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Brain+research&rft.issn=00068993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-28 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Efficacy of Micafungin in Experimental Hematogenous Candida Meningoencephalitis: 1, 3-β-D-Glucan as a Surrogate Marker for Detection and Therapeutic Response T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39285887; 4373732 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Petraitiene, R AU - Petraitis, V AU - Hope, W AU - Kelaher, A M AU - Cotton, M P AU - Hughes, J E AU - Mickiene, D AU - Schaufele, R L AU - Bacher, J AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Micafungin KW - Meningoencephalitis KW - Candida KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39285887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Efficacy+of+Micafungin+in+Experimental+Hematogenous+Candida+Meningoencephalitis%3A+1%2C+3-%26amp%3Bbeta%3B-D-Glucan+as+a+Surrogate+Marker+for+Detection+and+Therapeutic+Response&rft.au=Petraitiene%2C+R%3BPetraitis%2C+V%3BHope%2C+W%3BKelaher%2C+A+M%3BCotton%2C+M+P%3BHughes%2C+J+E%3BMickiene%2C+D%3BSchaufele%2C+R+L%3BBacher%2C+J%3BWalsh%2C+T+J&rft.aulast=Petraitiene&rft.aufirst=R&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mathematical Modeling (MM) of Galactomannan (GM) and Amphotericin B (AmB) in a Model of Early Invasive Pulmonary Aspergillosis T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39272327; 4372690 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Hope, W W AU - Kruhlak, M J AU - Lyman, C A AU - Petraitiene, R AU - Petraitis, V AU - Francesconi, A AU - Kasai, M AU - Mickiene, D AU - Sein, T AU - Demchok, J AU - Kelaher, A AU - Hughes, J AU - Cotton, M AU - Cotten, C AU - Bacher, J AU - Tripathi, S AU - Bermudas, L AU - Maugel, T AU - Zerfas, P AU - Wingard, J R AU - Drusano, G L AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Mathematical models KW - Aspergillosis KW - Lung KW - Amphotericin B KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39272327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Mathematical+Modeling+%28MM%29+of+Galactomannan+%28GM%29+and+Amphotericin+B+%28AmB%29+in+a+Model+of+Early+Invasive+Pulmonary+Aspergillosis&rft.au=Hope%2C+W+W%3BKruhlak%2C+M+J%3BLyman%2C+C+A%3BPetraitiene%2C+R%3BPetraitis%2C+V%3BFrancesconi%2C+A%3BKasai%2C+M%3BMickiene%2C+D%3BSein%2C+T%3BDemchok%2C+J%3BKelaher%2C+A%3BHughes%2C+J%3BCotton%2C+M%3BCotten%2C+C%3BBacher%2C+J%3BTripathi%2C+S%3BBermudas%2C+L%3BMaugel%2C+T%3BZerfas%2C+P%3BWingard%2C+J+R%3BDrusano%2C+G+L%3BWalsh%2C+T+J&rft.aulast=Hope&rft.aufirst=W&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Population Pharmacokinetics (PK) of Micafungin in Neonates and Children T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39272278; 4372689 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Hope, W W AU - Keirns, J J AU - Buell, D N AU - Seibel, N L AU - Heresi, G P AU - Drusano, G L AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Children KW - Neonates KW - Pharmacokinetics KW - Micafungin KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39272278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Population+Pharmacokinetics+%28PK%29+of+Micafungin+in+Neonates+and+Children&rft.au=Hope%2C+W+W%3BKeirns%2C+J+J%3BBuell%2C+D+N%3BSeibel%2C+N+L%3BHeresi%2C+G+P%3BDrusano%2C+G+L%3BWalsh%2C+T+J&rft.aulast=Hope&rft.aufirst=W&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Functional Genomics of Innate Host Defense Molecules in Human Monocytes Infected with Aspergillus fumigatus and Rhizopus Oryzae T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39271505; 4373762 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Cortez, K J AU - Lyman, C A AU - Lempicki, R AU - Ren, P AU - Yang, J AU - Cotten, C AU - Roilides, E AU - Kontoyiannis, D P AU - Kottilil, S AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Monocytes KW - Genomics KW - Insecticides KW - Aspergillus fumigatus KW - Rhizopus oryzae KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39271505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Comparative+Functional+Genomics+of+Innate+Host+Defense+Molecules+in+Human+Monocytes+Infected+with+Aspergillus+fumigatus+and+Rhizopus+Oryzae&rft.au=Cortez%2C+K+J%3BLyman%2C+C+A%3BLempicki%2C+R%3BRen%2C+P%3BYang%2C+J%3BCotten%2C+C%3BRoilides%2C+E%3BKontoyiannis%2C+D+P%3BKottilil%2C+S%3BWalsh%2C+T+J&rft.aulast=Cortez&rft.aufirst=K&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pro-Inflammatory Peptides of Staphylococcus aureus and their Role in Community-Acquired MRSA T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39264053; 4372729 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Wang, R AU - Braughton, K R AU - Kretschmer, D AU - Peschel, A AU - Deleo, F R AU - Otto, M Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Peptides KW - Staphylococcus aureus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39264053?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Pro-Inflammatory+Peptides+of+Staphylococcus+aureus+and+their+Role+in+Community-Acquired+MRSA&rft.au=Wang%2C+R%3BBraughton%2C+K+R%3BKretschmer%2C+D%3BPeschel%2C+A%3BDeleo%2C+F+R%3BOtto%2C+M&rft.aulast=Wang&rft.aufirst=R&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacokinetics (PK) and Pharmacodynamics (PD) of Micafungin in Experimental Hematogenous Candida Meningoencephalitis (HCME) T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39258585; 4372691 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Hope, W W AU - Mickiene, D AU - Petraitis, V AU - Petraitiene, R AU - Kelaher, A AU - Hughes, J AU - Cotton, M AU - Bacher, J AU - Groll, A H AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Pharmacokinetics KW - Micafungin KW - Meningoencephalitis KW - Pharmacodynamics KW - Pharmacology KW - Candida KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258585?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Pharmacokinetics+%28PK%29+and+Pharmacodynamics+%28PD%29+of+Micafungin+in+Experimental+Hematogenous+Candida+Meningoencephalitis+%28HCME%29&rft.au=Hope%2C+W+W%3BMickiene%2C+D%3BPetraitis%2C+V%3BPetraitiene%2C+R%3BKelaher%2C+A%3BHughes%2C+J%3BCotton%2C+M%3BBacher%2C+J%3BGroll%2C+A+H%3BWalsh%2C+T+J&rft.aulast=Hope&rft.aufirst=W&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Viral Breakthroughs (VB) to Pegylated Interferon (PEG-IFN) and Ribavirin (RBV) Therapy In HIV/HCV Coinfection: Role of Immunosuppression and Intrinsic Interferon Resistance T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39216334; 4373872 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Nussenblatt, V AU - McLaughlin, M AU - Lempicki, R AU - Brann, T AU - Proschan, M AU - Masur, H AU - Polis, M AU - Kottilil, S Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Interferon KW - Immunosuppression KW - Ribavirin KW - Therapy KW - Human immunodeficiency virus KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39216334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Viral+Breakthroughs+%28VB%29+to+Pegylated+Interferon+%28PEG-IFN%29+and+Ribavirin+%28RBV%29+Therapy+In+HIV%2FHCV+Coinfection%3A+Role+of+Immunosuppression+and+Intrinsic+Interferon+Resistance&rft.au=Nussenblatt%2C+V%3BMcLaughlin%2C+M%3BLempicki%2C+R%3BBrann%2C+T%3BProschan%2C+M%3BMasur%2C+H%3BPolis%2C+M%3BKottilil%2C+S&rft.aulast=Nussenblatt&rft.aufirst=V&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combination Therapy of Voriconazole and Anidulafungin Improves Outcome of Experimental Pulmonary Aspergillosis T2 - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AN - 39209503; 4373121 JF - 46th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2006) AU - Petraitis, V AU - Petratiene, R AU - Hope, W AU - Kelaher, A M AU - Hughes, J E AU - Cotton, M P AU - Sein, T AU - Mickiene, D AU - Bacher, J AU - Walsh, T J Y1 - 2006/09/27/ PY - 2006 DA - 2006 Sep 27 KW - Aspergillosis KW - Lung KW - Voriconazole KW - Therapy KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39209503?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.atitle=Combination+Therapy+of+Voriconazole+and+Anidulafungin+Improves+Outcome+of+Experimental+Pulmonary+Aspergillosis&rft.au=Petraitis%2C+V%3BPetratiene%2C+R%3BHope%2C+W%3BKelaher%2C+A+M%3BHughes%2C+J+E%3BCotton%2C+M+P%3BSein%2C+T%3BMickiene%2C+D%3BBacher%2C+J%3BWalsh%2C+T+J&rft.aulast=Petraitis&rft.aufirst=V&rft.date=2006-09-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=46th+Annual+Interscience+Conference+on+Antimicrobial+Agents+and+Chemotherapy+%28ICAAC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey={B9DB828F -3AAE-421F-8751-A2D0757134CF}&AKey={32093528-52DC-4EBE-9D80-29DAD84C 92CE} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Histidine triad-like motif of the rotavirus NSP2 octamer mediates both RTPase and NTPase activities. AN - 68829472; 16934294 AB - Rotavirus NSP2 is an abundant non-structural RNA-binding protein essential for forming the viral factories that support replication of the double-stranded RNA genome. NSP2 exists as stable doughnut-shaped octamers within the infected cell, representing the tail-to-tail interaction of two tetramers. Extending diagonally across the surface of each octamer are four highly basic grooves that function as binding sites for single-stranded RNA. Between the N and C-terminal domains of each monomer is a deep electropositive cleft containing a catalytic site that hydrolyzes the gamma-beta phosphoanhydride bond of any NTP. The catalytic site has similarity to those of the histidine triad (HIT) family of nucleotide-binding proteins. Due to the close proximity of the grooves and clefts, we investigated the possibility that the RNA-binding activity of the groove promoted the insertion of the 5'-triphosphate moiety of the RNA into the cleft, and the subsequent hydrolysis of its gamma-beta phosphoanhydride bond. Our results show that NSP2 hydrolyzes the gammaP from RNAs and NTPs through Mg(2+)-dependent activities that proceed with similar reaction velocities, that require the catalytic His225 residue, and that produce a phosphorylated intermediate. Competition assays indicate that although both substrates enter the active site, RNA is the preferred substrate due to its higher affinity for the octamer. The RNA triphosphatase (RTPase) activity of NSP2 may account for the absence of the 5'-terminal gammaP on the (-) strands of the double-stranded RNA genome segments. This is the first report of a HIT-like protein with a multifunctional catalytic site, capable of accommodating both NTPs and RNAs during gammaP hydrolysis. JF - Journal of molecular biology AU - Vasquez-Del Carpio, Rodrigo AU - Gonzalez-Nilo, Fernando D AU - Riadi, Gonzalo AU - Taraporewala, Zenobia F AU - Patton, John T AD - Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/09/22/ PY - 2006 DA - 2006 Sep 22 SP - 539 EP - 554 VL - 362 IS - 3 SN - 0022-2836, 0022-2836 KW - DNA, Viral KW - 0 KW - RNA, Viral KW - RNA-Binding Proteins KW - Recombinant Proteins KW - Viral Nonstructural Proteins KW - NS35 protein, rotavirus KW - 138414-65-0 KW - Histidine KW - 4QD397987E KW - Acid Anhydride Hydrolases KW - EC 3.6.- KW - RNA triphosphatase KW - EC 3.6.1.- KW - Nucleoside-Triphosphatase KW - EC 3.6.1.15 KW - Index Medicus KW - Rotavirus -- metabolism KW - Amino Acid Sequence KW - Recombinant Proteins -- genetics KW - Models, Biological KW - Protein Structure, Quaternary KW - Binding Sites KW - Static Electricity KW - Histidine -- chemistry KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Amino Acid Motifs KW - Phosphorylation KW - Recombinant Proteins -- metabolism KW - Kinetics KW - RNA, Viral -- chemistry KW - Molecular Sequence Data KW - Substrate Specificity KW - Rotavirus -- genetics KW - Recombinant Proteins -- chemistry KW - RNA, Viral -- genetics KW - Sequence Homology, Amino Acid KW - RNA, Viral -- metabolism KW - DNA, Viral -- genetics KW - Amino Acid Substitution KW - Viral Nonstructural Proteins -- genetics KW - RNA-Binding Proteins -- metabolism KW - RNA-Binding Proteins -- genetics KW - Viral Nonstructural Proteins -- chemistry KW - Nucleoside-Triphosphatase -- metabolism KW - Acid Anhydride Hydrolases -- metabolism KW - RNA-Binding Proteins -- chemistry KW - Viral Nonstructural Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68829472?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+molecular+biology&rft.atitle=Histidine+triad-like+motif+of+the+rotavirus+NSP2+octamer+mediates+both+RTPase+and+NTPase+activities.&rft.au=Vasquez-Del+Carpio%2C+Rodrigo%3BGonzalez-Nilo%2C+Fernando+D%3BRiadi%2C+Gonzalo%3BTaraporewala%2C+Zenobia+F%3BPatton%2C+John+T&rft.aulast=Vasquez-Del+Carpio&rft.aufirst=Rodrigo&rft.date=2006-09-22&rft.volume=362&rft.issue=3&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+molecular+biology&rft.issn=00222836&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-24 N1 - Date created - 2006-09-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 2002 May;76(10):5291-9 [11967345] J Biol Chem. 2002 May 3;277(18):15317-24 [11844801] Nature. 2002 May 16;417(6886):311-5 [12015608] Virology. 2002 Jul 20;299(1):122-32 [12167347] Emerg Infect Dis. 2003 May;9(5):565-72 [12737740] J Biol Chem. 2004 Feb 6;279(6):4394-403 [14613938] J Biol Chem. 2004 Mar 12;279(11):10624-33 [14699117] Virus Res. 2004 Apr;101(1):57-66 [15010217] Mol Cell. 2004 Apr 9;14(1):67-80 [15068804] J Virol. 2004 Jul;78(14):7763-74 [15220450] J Virol. 2004 Jul;78(14):7833-8 [15220459] Virology. 2004 Oct 25;328(2):208-18 [15464841] J Gen Virol. 1977 Sep;36(3):395-402 [21225] J Gen Virol. 1982 Dec;63(2):457-67 [6296288] Virology. 1983 Apr 15;126(1):204-12 [6302982] J Virol. 1983 Jul;47(1):125-36 [6306269] J Virol. 1984 Oct;52(1):188-97 [6090696] Virus Res. 1984;1(2):133-52 [6099654] Virology. 1986 Dec;155(2):655-65 [3024405] J Mol Biol. 1988 Jan 20;199(2):269-75 [2832610] Virology. 1989 Oct;172(2):616-27 [2552662] Virology. 1992 May;188(1):77-84 [1314468] Virology. 1992 Dec;191(2):698-708 [1333119] Virology. 1994 Aug 1;202(2):803-13 [8030243] J Virol. 1996 Feb;70(2):985-91 [8551639] J Biol Chem. 1996 May 17;271(20):11945-52 [8662636] Nature. 1996 Aug 1;382(6590):471-3 [8684490] J Virol. 1997 Jan;71(1):34-41 [8985320] Nat Struct Biol. 1997 Feb;4(2):118-21 [9033591] Cell. 1997 Jun 13;89(6):867-73 [9200605] Science. 1997 Oct 10;278(5336):286-90 [9323207] J Gen Virol. 1999 Feb;80 ( Pt 2):333-9 [10073692] J Gen Virol. 2005 May;86(Pt 5):1481-7 [15831961] J Biol Chem. 2005 May 6;280(18):17848-56 [15713658] J Virol. 2006 Aug;80(16):7984-94 [16873255] J Virol. 2006 Nov;80(21):10829-35 [16928740] J Virol. 1999 Dec;73(12):9934-43 [10559306] Cell. 1999 Nov 24;99(5):533-43 [10589681] Virology. 1999 Dec 5;265(1):120-30 [10603323] J Biol Chem. 2000 Jun 9;275(23):17281-7 [10748213] J Virol. 2000 Jul;74(13):5939-48 [10846075] RNA. 2000 Oct;6(10):1455-67 [11073221] Virology. 2001 Feb 15;280(2):221-31 [11162836] J Biol Chem. 2001 Mar 30;276(13):9679-87 [11121414] J Virol. 2001 May;75(10):4519-27 [11312322] EMBO J. 2001 May 15;20(10):2575-86 [11350947] Cell. 2001 Dec 14;107(6):751-62 [11747811] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - A Novel Strategy for In Vivo @@u13@C MRS using Very Low RF Power for Proton Decoupling T2 - 23rd Annual Business Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2006) AN - 40456374; 4471464 JF - 23rd Annual Business Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB 2006) AU - Li, S. AU - Yang, J AU - Shen, J Y1 - 2006/09/21/ PY - 2006 DA - 2006 Sep 21 KW - Protons UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40456374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=23rd+Annual+Business+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2006%29&rft.atitle=A+Novel+Strategy+for+In+Vivo+%40%40u13%40C+MRS+using+Very+Low+RF+Power+for+Proton+Decoupling&rft.au=Li%2C+S.%3BYang%2C+J%3BShen%2C+J&rft.aulast=Li&rft.aufirst=S.&rft.date=2006-09-21&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=23rd+Annual+Business+Meeting+of+the+European+Society+for+Magnetic+Resonance+in+Medicine+and+Biology+%28ESMRMB+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractonline.com/viewer/?mkey=%7B3B01A8F0%2DB94D%2D4C9C%2 D851A%2DBDCDB63032AC%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Scaffold Role of the Fibrous Sheath T2 - 10th International Symposium on Spermatology AN - 40462193; 4475082 JF - 10th International Symposium on Spermatology AU - Eddy, E M Y1 - 2006/09/17/ PY - 2006 DA - 2006 Sep 17 KW - Scaffolds KW - Sheaths KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40462193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Symposium+on+Spermatology&rft.atitle=The+Scaffold+Role+of+the+Fibrous+Sheath&rft.au=Eddy%2C+E+M&rft.aulast=Eddy&rft.aufirst=E&rft.date=2006-09-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Symposium+on+Spermatology&rft.issn=&rft_id=info:doi/ L2 - http://www.spermadrid2006.org/archivos/File/Spermadrid/Spermadrid_Abst racts.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Novel Targets for Cancer Treatment T2 - XXXIVth Meeting of the International Society for Oncodevelopmental Biology and Medicine AN - 40358280; 4420664 JF - XXXIVth Meeting of the International Society for Oncodevelopmental Biology and Medicine AU - Low, Jennifer Y1 - 2006/09/16/ PY - 2006 DA - 2006 Sep 16 KW - Cancer KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358280?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIVth+Meeting+of+the+International+Society+for+Oncodevelopmental+Biology+and+Medicine&rft.atitle=Novel+Targets+for+Cancer+Treatment&rft.au=Low%2C+Jennifer&rft.aulast=Low&rft.aufirst=Jennifer&rft.date=2006-09-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIVth+Meeting+of+the+International+Society+for+Oncodevelopmental+Biology+and+Medicine&rft.issn=&rft_id=info:doi/ L2 - https://www.cityofhope.org/ISOBM/DraftPROGRAM.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proteomic Exploration of Formalin-Fixed, Paraffin-Embedded Tissue Archive for Biomarker Discovery T2 - XXXIVth Meeting of the International Society for Oncodevelopmental Biology and Medicine AN - 40356898; 4420686 JF - XXXIVth Meeting of the International Society for Oncodevelopmental Biology and Medicine AU - Veenstra, Timothy Y1 - 2006/09/16/ PY - 2006 DA - 2006 Sep 16 KW - Bioindicators KW - Proteomics KW - Biomarkers KW - Archives KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356898?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XXXIVth+Meeting+of+the+International+Society+for+Oncodevelopmental+Biology+and+Medicine&rft.atitle=Proteomic+Exploration+of+Formalin-Fixed%2C+Paraffin-Embedded+Tissue+Archive+for+Biomarker+Discovery&rft.au=Veenstra%2C+Timothy&rft.aulast=Veenstra&rft.aufirst=Timothy&rft.date=2006-09-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XXXIVth+Meeting+of+the+International+Society+for+Oncodevelopmental+Biology+and+Medicine&rft.issn=&rft_id=info:doi/ L2 - https://www.cityofhope.org/ISOBM/DraftPROGRAM.doc LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prefrontal electrophysiologic "noise" and catechol-O-methyltransferase genotype in schizophrenia. AN - 68880258; 16730334 AB - Increased variability of stimulus-induced prefrontal electromagnetic activity ("noise") has been associated with genetic risk for schizophrenia. On the basis of animal experiments and computational models, we have predicted that this prefrontal "noise" phenotype would be related to variation in prefrontal dopamine (DA) signaling, which itself might be abnormal in schizophrenia. In the present study, the effect of a functional single nucleotide polymorphism (val(108/158)met) within the catechol-O-methyltransferase (COMT) gene on prefrontal "noise" was examined, because the COMT enzyme is involved in cortical synaptic dopamine metabolism and weakly predictive of risk for schizophrenia. A Caucasian sample comprising 112 unrelated normal subjects, 83 schizophrenic probands, and 87 of their unaffected siblings was investigated, all of whom had measures of prefrontal "noise" estimated from event-related electroencephalogram during an auditory oddball task. The val(108/158)met genotype was significantly associated with prefrontal "noise"; homozygous Val-carriers had greatest prefrontal "noise" values; odds ratio (OR) = 2.37 (95% confidence interval [CI] 1.37-4.10), p = 003. The genotype-phenotype association was stronger when only considering male subjects with an OR = 3.37 (95% CI: 1.63-6.98), p = 002. The results suggest that COMT genotype impacts the level of prefrontal physiologic "noise." JF - Biological psychiatry AU - Winterer, Georg AU - Egan, Michael F AU - Kolachana, Bhaskar S AU - Goldberg, Terry E AU - Coppola, Richard AU - Weinberger, Daniel R AD - Genes, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/09/15/ PY - 2006 DA - 2006 Sep 15 SP - 578 EP - 584 VL - 60 IS - 6 SN - 0006-3223, 0006-3223 KW - Methionine KW - AE28F7PNPL KW - Catechol O-Methyltransferase KW - EC 2.1.1.6 KW - Valine KW - HG18B9YRS7 KW - Index Medicus KW - Odds Ratio KW - Analysis of Variance KW - Sex Factors KW - Gene Frequency KW - DNA Mutational Analysis KW - Humans KW - Retrospective Studies KW - Valine -- genetics KW - Acoustic Stimulation -- methods KW - Genotype KW - Methionine -- genetics KW - Adult KW - Confidence Intervals KW - Middle Aged KW - Adolescent KW - Polymorphism, Single Nucleotide -- genetics KW - Female KW - Male KW - Catechol O-Methyltransferase -- physiology KW - Prefrontal Cortex -- physiopathology KW - Noise KW - Genetic Predisposition to Disease KW - Schizophrenia -- pathology KW - Schizophrenia -- genetics KW - Schizophrenia -- physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68880258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+psychiatry&rft.atitle=Prefrontal+electrophysiologic+%22noise%22+and+catechol-O-methyltransferase+genotype+in+schizophrenia.&rft.au=Winterer%2C+Georg%3BEgan%2C+Michael+F%3BKolachana%2C+Bhaskar+S%3BGoldberg%2C+Terry+E%3BCoppola%2C+Richard%3BWeinberger%2C+Daniel+R&rft.aulast=Winterer&rft.aufirst=Georg&rft.date=2006-09-15&rft.volume=60&rft.issue=6&rft.spage=578&rft.isbn=&rft.btitle=&rft.title=Biological+psychiatry&rft.issn=00063223&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-09-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene interaction network analysis suggests differences between high and low doses of acetaminophen. AN - 68823524; 16701773 AB - Bayesian networks for quantifying linkages between genes were applied to detect differences in gene expression interaction networks between multiple doses of acetaminophen at multiple time points. Seventeen (17) genes were selected from the gene expression profiles from livers of rats orally exposed to 50, 150 and 1500 mg/kg acetaminophen (APAP) at 6, 24 and 48 h after exposure using a variety of statistical and bioinformatics approaches. The selected genes are related to three biological categories: apoptosis, oxidative stress and other. Gene interaction networks between all 17 genes were identified for the nine dose-time observation points by the TAO-Gen algorithm. Using k-means clustering analysis, the estimated nine networks could be clustered into two consensus networks, the first consisting of the low and middle dose groups, and the second consisting of the high dose. The analysis suggests that the networks could be segregated by doses and were consistent in structure over time of observation within grouped doses. The consensus networks were quantified to calculate the probability distribution for the strength of the linkage between genes connected in the networks. The quantifying analysis showed that, at lower doses, the genes related to the oxidative stress signaling pathway did not interact with the apoptosis-related genes. In contrast, the high-dose network demonstrated significant interactions between the oxidative stress genes and the apoptosis genes and also demonstrated a different network between genes in the oxidative stress pathway. The approaches shown here could provide predictive information to understand high- versus low-dose mechanisms of toxicity. JF - Toxicology and applied pharmacology AU - Toyoshiba, Hiroyoshi AU - Sone, Hideko AU - Yamanaka, Takeharu AU - Parham, Frederick M AU - Irwin, Richard D AU - Boorman, Gary A AU - Portier, Christopher J AD - Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. toyoshiba.hiroyoshi@nies.go.jp Y1 - 2006/09/15/ PY - 2006 DA - 2006 Sep 15 SP - 306 EP - 316 VL - 215 IS - 3 SN - 0041-008X, 0041-008X KW - Analgesics, Non-Narcotic KW - 0 KW - Acetaminophen KW - 362O9ITL9D KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Apoptosis KW - Oxidative Stress KW - Bayes Theorem KW - Gene Expression Regulation -- drug effects KW - Male KW - Gene Expression Profiling KW - Liver -- drug effects KW - Models, Genetic KW - Analgesics, Non-Narcotic -- toxicity KW - Liver -- metabolism KW - Acetaminophen -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68823524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+applied+pharmacology&rft.atitle=Gene+interaction+network+analysis+suggests+differences+between+high+and+low+doses+of+acetaminophen.&rft.au=Toyoshiba%2C+Hiroyoshi%3BSone%2C+Hideko%3BYamanaka%2C+Takeharu%3BParham%2C+Frederick+M%3BIrwin%2C+Richard+D%3BBoorman%2C+Gary+A%3BPortier%2C+Christopher+J&rft.aulast=Toyoshiba&rft.aufirst=Hiroyoshi&rft.date=2006-09-15&rft.volume=215&rft.issue=3&rft.spage=306&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+applied+pharmacology&rft.issn=0041008X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Enhanced urinary bladder and liver carcinogenesis in male CD1 mice exposed to transplacental inorganic arsenic and postnatal diethylstilbestrol or tamoxifen AN - 19344112; 7084141 AB - Pregnant CD1 mice received 85 ppm arsenite in the drinking water from gestation day 8 to 18, groups (n = 35) of male offspring were subsequently injected on postpartum days 1 through 5 with diethylstilbestrol (DES; 2 mu g/pup/day) or tamoxifen (TAM; 10 mu g /pup/day), and tumor formation was assessed over 90 weeks. Arsenic alone increased hepatocellular carcinoma (14%), adenoma (23%) and total tumors (31%) compared to control (0, 2 and 2%, respectively). Arsenic alone also increased lung adenocarcinoma, adrenal cortical adenoma and renal cystic tubular hyperplasia compared to control. Compared to arsenic alone, arsenic plus DES increased liver tumor incidence in mice at risk 2.2-fold and increased liver tumor multiplicity (tumors/liver) 1.8-fold. The treatments alone did not impact urinary bladder carcinogenesis, but arsenic plus TAM significantly increased formation of urinary bladder transitional cell tumors (papilloma and carcinoma; 13%) compared to control (0%). Urinary bladder proliferative lesions (combined tumors and hyperplasia) were also increased by arsenic plus TAM (40%) or arsenic plus DES (43%) compared to control (0%) or the treatments alone. Urinary bladder proliferative lesions occurred in the absence of any evidence of uroepithelial cytotoxic lesions. Urinary bladder lesions and hepatocellular carcinoma induced by arsenic plus TAM and/or DES overexpressed estrogen receptor- alpha , indicating that aberrant estrogen signaling may have been a factor in the enhanced carcinogenic response. Thus, in male CD1 mice, gestational arsenic exposure alone induced liver adenoma and carcinoma, lung adenocarcinoma, adrenal adenoma and renal cystic hyperplasia. Furthermore, DES enhanced transplacental arsenic-induced hepatocarcinogenesis. In utero arsenic also initiated urinary bladder tumor formation when followed by postnatal TAM and uroepithelial proliferative lesions when followed by TAM or DES. JF - Toxicology and Applied Pharmacology AU - Waalkes, M P AU - Liu, J AU - Ward, J M AU - Diwan, BA AD - Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, PO Box 12233, Mail Drop F0-09, 111 Alexander Drive, Research Triangle Park, NC 27709, USA, waalkes@niehs.nih.gov Y1 - 2006/09/15/ PY - 2006 DA - 2006 Sep 15 SP - 295 EP - 305 PB - Elsevier Inc. VL - 215 IS - 3 SN - 0041-008X, 0041-008X KW - Toxicology Abstracts KW - Risk assessment KW - Arsenic KW - Lung carcinoma KW - Urinary bladder KW - Arsenite KW - Tamoxifen KW - Pregnancy KW - Carcinoma KW - Hyperplasia KW - Cytotoxicity KW - Postpartum KW - Gestation KW - Carcinogenesis KW - Kidney KW - Progeny KW - Adenocarcinoma KW - Diethylstilbestrol KW - Drinking water KW - Papilloma KW - Estrogen receptors KW - Adenoma KW - Hepatocellular carcinoma KW - Signal transduction KW - X 24320:Food Additives & Contaminants UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19344112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Enhanced+urinary+bladder+and+liver+carcinogenesis+in+male+CD1+mice+exposed+to+transplacental+inorganic+arsenic+and+postnatal+diethylstilbestrol+or+tamoxifen&rft.au=Waalkes%2C+M+P%3BLiu%2C+J%3BWard%2C+J+M%3BDiwan%2C+BA&rft.aulast=Waalkes&rft.aufirst=M&rft.date=2006-09-15&rft.volume=215&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2006.03.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Risk assessment; Arsenic; Urinary bladder; Lung carcinoma; Arsenite; Tamoxifen; Carcinoma; Pregnancy; Postpartum; Cytotoxicity; Hyperplasia; Carcinogenesis; Gestation; Kidney; Progeny; Papilloma; Drinking water; Diethylstilbestrol; Adenocarcinoma; Adenoma; Estrogen receptors; Signal transduction; Hepatocellular carcinoma DO - http://dx.doi.org/10.1016/j.taap.2006.03.010 ER - TY - JOUR T1 - H pylori status and angiogenesis factors in human gastric carcinoma. AN - 68903836; 17006982 AB - To investigate H pylori expression in gastric cancer patients in relation to primary tumor angiogenic markers, such as microvessel density (MVD), thymidine phosphorylase (TP), vascular endothelial growth factor receptor-1 (VEGF-R1), p53 and circulating VEGF levels. Angiogenic markers were analyzed immunohistochemically in 56 primary gastric cancers. H pylori cytotoxin (vacA) and the cytotoxin-associated gene (cagA) amplification were evaluated using PCR assay. Serum H pylori IgG antibodies and serum/plasma circulating VEGF levels were detected in 39 and 38 patients by ELISA, respectively. A total of 69% of patients were positive for circulating IgG antibodies against H pylori. cagA-positive H pylori strains were found in 41% of gastric patients. vacA was found in 50% of patients; s1 strains were more highly expressed among vacA-positive patients. The presence of the s1 strain was significantly associated with cagA (P = 0.0001). MVD was significantly correlated with both tumor VEGF expression (r = 0.361, P = 0.009) and serum VEGF levels (r = -0.347, P = 0.041). Conversely, neither VEGF-R1 expression nor MVD was related to p53 expression. However, H pylori was not related to any angiogenic markers except for the plasma VEGF level (P = 0.026). H pylori antigen is related to higher plasma VEGF levels, but not to angiogenic characteristics. It can be hypothesized that the toxic effects of H pylori on angiogenesis occurs in early preclinical disease phase or in long-lasting aggressive infections, but only when high H pylori IgG levels are persistent. JF - World journal of gastroenterology AU - Mangia, Anita AU - Chiriatti, Annalisa AU - Ranieri, Girolamo AU - Abbate, Ines AU - Coviello, Maria AU - Simone, Giovanni AU - Zito, Francesco Alfredo AU - Montemurro, Severino AU - Rucci, Antonello AU - Di Leo, Alfredo AU - Tommasi, Stefania AU - Berloco, Pasquale AU - Xu, Jian Ming AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, National Cancer Institute, Via Amendola 209, Bari 70126, Italy. Y1 - 2006/09/14/ PY - 2006 DA - 2006 Sep 14 SP - 5465 EP - 5472 VL - 12 IS - 34 SN - 1007-9327, 1007-9327 KW - Antigens, Bacterial KW - 0 KW - Bacterial Proteins KW - Biomarkers, Tumor KW - Immunoglobulin G KW - Tumor Suppressor Protein p53 KW - VacA protein, Helicobacter pylori KW - Vascular Endothelial Growth Factor A KW - cagA protein, Helicobacter pylori KW - Thymidine Phosphorylase KW - EC 2.4.2.4 KW - Receptors, Vascular Endothelial Growth Factor KW - EC 2.7.10.1 KW - Index Medicus KW - Biomarkers, Tumor -- genetics KW - Bacterial Proteins -- genetics KW - Vascular Endothelial Growth Factor A -- blood KW - Humans KW - Aged KW - Thymidine Phosphorylase -- genetics KW - Antigens, Bacterial -- genetics KW - Gene Expression Regulation, Neoplastic KW - Biomarkers, Tumor -- metabolism KW - Aged, 80 and over KW - Adult KW - Tumor Suppressor Protein p53 -- genetics KW - Male KW - Gene Expression Regulation, Bacterial KW - Antigens, Bacterial -- metabolism KW - Receptors, Vascular Endothelial Growth Factor -- metabolism KW - Bacterial Proteins -- metabolism KW - Receptors, Vascular Endothelial Growth Factor -- genetics KW - Tumor Suppressor Protein p53 -- metabolism KW - Thymidine Phosphorylase -- metabolism KW - Immunoglobulin G -- blood KW - Immunoglobulin G -- genetics KW - Middle Aged KW - Microcirculation KW - Female KW - Vascular Endothelial Growth Factor A -- metabolism KW - Neovascularization, Pathologic -- physiopathology KW - Stomach Neoplasms -- metabolism KW - Helicobacter pylori -- immunology KW - Stomach Neoplasms -- blood supply KW - Helicobacter Infections -- complications KW - Helicobacter pylori -- genetics KW - Neovascularization, Pathologic -- metabolism KW - Helicobacter pylori -- pathogenicity KW - Stomach Neoplasms -- microbiology KW - Stomach Neoplasms -- genetics KW - Neovascularization, Pathologic -- genetics KW - Helicobacter Infections -- metabolism KW - Helicobacter Infections -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68903836?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+journal+of+gastroenterology&rft.atitle=H+pylori+status+and+angiogenesis+factors+in+human+gastric+carcinoma.&rft.au=Mangia%2C+Anita%3BChiriatti%2C+Annalisa%3BRanieri%2C+Girolamo%3BAbbate%2C+Ines%3BCoviello%2C+Maria%3BSimone%2C+Giovanni%3BZito%2C+Francesco+Alfredo%3BMontemurro%2C+Severino%3BRucci%2C+Antonello%3BDi+Leo%2C+Alfredo%3BTommasi%2C+Stefania%3BBerloco%2C+Pasquale%3BXu%2C+Jian+Ming%3BParadiso%2C+Angelo&rft.aulast=Mangia&rft.aufirst=Anita&rft.date=2006-09-14&rft.volume=12&rft.issue=34&rft.spage=5465&rft.isbn=&rft.btitle=&rft.title=World+journal+of+gastroenterology&rft.issn=10079327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-03 N1 - Date created - 2006-09-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Chem. 1994 Apr 8;269(14):10566-73 [8144644] J Pathol. 2005 Nov;207(3):277-84 [16184519] Cancer Res. 1995 May 15;55(10):2111-5 [7743510] Scand J Gastroenterol Suppl. 1995;208:33-46 [7777803] J Biol Chem. 1995 Jul 28;270(30):17771-7 [7629077] J Natl Cancer Inst. 1995 Dec 6;87(23):1777-80 [7473834] J Gastroenterol. 1996 Jun;31(3):329-32 [8726822] Eur J Cancer. 1996 Dec;32A(14):2474-84 [9059336] J Gastroenterol Hepatol. 1997 Jun;12(6):425-8 [9195398] Dig Dis Sci. 1997 Aug;42(8):1652-9 [9286230] J Clin Invest. 1998 Apr 15;101(8):1604-13 [9541490] N Engl J Med. 2001 Sep 13;345(11):784-9 [11556297] Carcinogenesis. 2002 Mar;23(3):419-24 [11895856] Oncology. 2002;62(3):278-85 [12065876] Cancer. 2002 Aug 1;95(3):499-505 [12209741] Dig Liver Dis. 2002 Jul;34(7):498-505 [12236483] Hepatogastroenterology. 2002 Sep-Oct;49(47):1453-6 [12239965] BMC Cancer. 2002 Apr 29;2:8 [11978184] Dig Liver Dis. 2002 Sep;34(9):621-5 [12405247] Int J Biol Markers. 2002 Jul-Sep;17(3):201-14 [12408472] Int J Oncol. 2002 Dec;21(6):1317-23 [12429983] World J Gastroenterol. 2002 Dec;8(6):994-8 [12439912] Pol Merkur Lekarski. 2002 Sep;13(75):216-20 [12474574] Carcinogenesis. 2003 Jan;24(1):145; author reply 147 [12538360] J Gastroenterol. 2003;38(1):28-36 [12560919] Clin Cancer Res. 2003 Jun;9(6):2015-21 [12796363] Biochem Biophys Res Commun. 2003 Nov 28;311(4):809-14 [14623253] Oncol Rep. 2004 Feb;11(2):435-9 [14719080] Anticancer Res. 2004 Jan-Feb;24(1):1-10 [15015569] Cancer Res. 1991 Jun 1;51(11):3056-8 [2032245] Infect Immun. 1991 Sep;59(9):3343-5 [1879950] Cancer Res. 1991 Nov 1;51(21):5800-5 [1933850] J Clin Microbiol. 1992 Jan;30(1):192-200 [1734052] J Biol Chem. 1992 May 25;267(15):10570-5 [1587837] Eur J Clin Microbiol Infect Dis. 1992 Jul;11(7):583-8 [1396764] J Clin Microbiol. 1992 Dec;30(12):3230-3 [1452707] Cancer. 2000 May 15;88(10):2220-7 [10820342] Int J Cancer. 2000 Aug 1;87(3):322-7 [10897035] Cancer Epidemiol Biomarkers Prev. 2000 Sep;9(9):981-5 [11008919] Dig Liver Dis. 2000 Jun-Jul;32(5):378-83 [11030181] Oncol Res. 2000;12(1):33-41 [11061344] Int J Cancer. 2001 Feb 15;91(4):481-5 [11251969] Nat Rev Mol Cell Biol. 2001 Jun;2(6):457-66 [11389469] Pathol Oncol Res. 2001;7(2):129-34 [11458276] Infect Immun. 1993 May;61(5):1799-809 [8478069] Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5791-5 [8516329] Am J Gastroenterol. 1993 Nov;88(11):1916-9 [8237942] Am J Pathol. 1994 Mar;144(3):511-7 [8129036] Ital J Gastroenterol Hepatol. 1997 Jun;29(3):214-9 [9646212] Gastroenterology. 1998 Jul;115(1):58-66 [9649459] J Clin Microbiol. 1998 Nov;36(11):3433-4 [9774616] J Biol Chem. 1998 Oct 30;273(44):28560-3 [9786845] Clin Cancer Res. 1996 Oct;2(10):1679-84 [9816116] Ital J Gastroenterol Hepatol. 1998 Oct;30(5):484-9 [9836101] Am J Gastroenterol. 1994 Aug;89(8 Suppl):S116-28 [8048402] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Echinocandins for candidemia in adults without neutropenia. AN - 68853469; 16971721 JF - The New England journal of medicine AU - Bennett, John E AD - Clinical Mycology Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/09/14/ PY - 2006 DA - 2006 Sep 14 SP - 1154 EP - 1159 VL - 355 IS - 11 KW - Antifungal Agents KW - 0 KW - Echinocandins KW - Lipopeptides KW - Lipoproteins KW - Peptides, Cyclic KW - beta-Glucans KW - beta-1,3-glucan KW - 9051-97-2 KW - anidulafungin KW - 9HLM53094I KW - caspofungin KW - F0XDI6ZL63 KW - micafungin KW - R10H71BSWG KW - Abridged Index Medicus KW - Index Medicus KW - Neutropenia KW - Peptides, Cyclic -- therapeutic use KW - Infusions, Intravenous KW - Lipoproteins -- therapeutic use KW - Humans KW - Practice Guidelines as Topic KW - Cross Infection -- drug therapy KW - Middle Aged KW - Candida -- isolation & purification KW - Microbial Sensitivity Tests KW - Male KW - Candidiasis -- drug therapy KW - beta-Glucans -- antagonists & inhibitors KW - Antifungal Agents -- adverse effects KW - Fungemia -- drug therapy KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68853469?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+New+England+journal+of+medicine&rft.atitle=Echinocandins+for+candidemia+in+adults+without+neutropenia.&rft.au=Bennett%2C+John+E&rft.aulast=Bennett&rft.aufirst=John&rft.date=2006-09-14&rft.volume=355&rft.issue=11&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=The+New+England+journal+of+medicine&rft.issn=1533-4406&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-21 N1 - Date created - 2006-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: N Engl J Med. 2006 Dec 28;355(26):2791-2; author reply 2792 [17192549] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Proline oxidase activates both intrinsic and extrinsic pathways for apoptosis: the role of ROS/superoxides, NFAT and MEK/ERK signaling. AN - 68850508; 16619034 AB - Proline oxidase (POX), often considered a 'housekeeping enzyme' might play an important role in apoptosis. We have shown that POX generated proline-dependent reactive oxygen species (ROS), specifically superoxide radicals, and induced apoptosis through the mitochondrial (intrinsic) pathway. In our current report, we used DLD-1 colorectal cancer cells stably transfected with the POX gene under the control of a tetracycline-inducible promoter and found POX-stimulated expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL), DR5 and cleavage of caspase-8. Importantly, apoptosis measured by flow cytometry was partially inhibited by Z-IETD-FMK, a specific inhibitor of caspase-8. These findings suggest that the extrinsic (death receptor) pathway also is activated by POX. Furthermore, the mechanism of this effect on the extrinsic pathway, specifically, the induction of TRAIL by POX, may be mediated by NFAT transcription factors. Additionally, POX expression also dramatically decreased phosphorylation of MEK and ERK, and the decrease was partially reversed by expression of manganese superoxide dismutase (MnSOD). Overexpression of constitutively active form of MEK, acMEK, partially blocked POX-induced apoptosis. These findings suggest the involvement of MEK/ERK signaling and further confirm the role of ROS/superoxides in POX-induced apoptosis. Combined with previously published data, we conclude that POX may induce apoptosis through both intrinsic and extrinsic pathways and is involved in nuclear factor of activated T cells (NFAT) signaling and regulation of the MEK/ERK pathway. It is suggested that, as a nutrition factor, POX may modulate apoptosis signals induced by p53 or other anti-cancer agents and enhance apoptosis in stress situations. JF - Oncogene AU - Liu, Y AU - Borchert, G L AU - Surazynski, A AU - Hu, C-A AU - Phang, J M AD - Metabolism and Cancer Susceptibility Section, Laboratory of Comparative Carcinogenesis, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. Y1 - 2006/09/14/ PY - 2006 DA - 2006 Sep 14 SP - 5640 EP - 5647 VL - 25 IS - 41 SN - 0950-9232, 0950-9232 KW - NFATC Transcription Factors KW - 0 KW - Reactive Oxygen Species KW - Superoxides KW - 11062-77-4 KW - Proline Oxidase KW - EC 1.5.3.- KW - Extracellular Signal-Regulated MAP Kinases KW - EC 2.7.11.24 KW - MAP Kinase Kinase Kinases KW - EC 2.7.11.25 KW - Index Medicus KW - Humans KW - Cell Line, Tumor KW - MAP Kinase Kinase Kinases -- metabolism KW - Reactive Oxygen Species -- metabolism KW - Superoxides -- metabolism KW - Apoptosis KW - Proline Oxidase -- metabolism KW - NFATC Transcription Factors -- metabolism KW - Extracellular Signal-Regulated MAP Kinases -- metabolism KW - Signal Transduction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68850508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=Proline+oxidase+activates+both+intrinsic+and+extrinsic+pathways+for+apoptosis%3A+the+role+of+ROS%2Fsuperoxides%2C+NFAT+and+MEK%2FERK+signaling.&rft.au=Liu%2C+Y%3BBorchert%2C+G+L%3BSurazynski%2C+A%3BHu%2C+C-A%3BPhang%2C+J+M&rft.aulast=Liu&rft.aufirst=Y&rft.date=2006-09-14&rft.volume=25&rft.issue=41&rft.spage=5640&rft.isbn=&rft.btitle=&rft.title=Oncogene&rft.issn=09509232&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-18 N1 - Date created - 2006-09-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Superior Hypogastric Block: Transdiscal versus Classic Posterior Approach in Pelvic Cancer Pain T2 - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AN - 40372657; 4424372 JF - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AU - Ali, G G AU - Helaly, M K AU - Labib, Y M Y1 - 2006/09/13/ PY - 2006 DA - 2006 Sep 13 KW - Pain KW - Cancer KW - Pelvis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40372657?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.atitle=Superior+Hypogastric+Block%3A+Transdiscal+versus+Classic+Posterior+Approach+in+Pelvic+Cancer+Pain&rft.au=Ali%2C+G+G%3BHelaly%2C+M+K%3BLabib%2C+Y+M&rft.aulast=Ali&rft.aufirst=G&rft.date=2006-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efic/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Superior Hypogastric Plexus Block: Transdiscal Approach versus Classic Posterior Approach in Pelvic Cancer Pain T2 - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AN - 40371097; 4424369 JF - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AU - El-Sayed, G G AU - Helaly, M A AU - Labib, Y M Y1 - 2006/09/13/ PY - 2006 DA - 2006 Sep 13 KW - Pain KW - Cancer KW - Pelvis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40371097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.atitle=Superior+Hypogastric+Plexus+Block%3A+Transdiscal+Approach+versus+Classic+Posterior+Approach+in+Pelvic+Cancer+Pain&rft.au=El-Sayed%2C+G+G%3BHelaly%2C+M+A%3BLabib%2C+Y+M&rft.aulast=El-Sayed&rft.aufirst=G&rft.date=2006-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efic/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preemptive use of Pregabalin in Postamputation Limb Pain in Cancer Hospital: A Randomized Double-Blind, Placebo-Controlled, Double Dose Study T2 - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AN - 40363210; 4424051 JF - 5th Congress of the European Federation of the International Association for the Study of Pain Chapters AU - Azer, M S AU - Abdelhalim, S M AU - Elsayed, G G Y1 - 2006/09/13/ PY - 2006 DA - 2006 Sep 13 KW - Pain KW - Hospitals KW - Cancer KW - Limbs KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40363210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.atitle=Preemptive+use+of+Pregabalin+in+Postamputation+Limb+Pain+in+Cancer+Hospital%3A+A+Randomized+Double-Blind%2C+Placebo-Controlled%2C+Double+Dose+Study&rft.au=Azer%2C+M+S%3BAbdelhalim%2C+S+M%3BElsayed%2C+G+G&rft.aulast=Azer&rft.aufirst=M&rft.date=2006-09-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Congress+of+the+European+Federation+of+the+International+Association+for+the+Study+of+Pain+Chapters&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efic/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Engineering RNA sequence specificity of Pumilio repeats. AN - 68860417; 16954190 AB - Puf proteins bind RNA sequence specifically and regulate translation and stability of target mRNAs. A "code" for RNA recognition has been deduced from crystal structures of the Puf protein, human Pumilio1, where each of eight repeats binds an RNA base via a combination of three side chains at conserved positions. Here, we report the creation of seven soluble mutant proteins with predictably altered sequence specificity, including one that binds tightly to adenosine-uracil-rich element RNA. These data show that Pumilio1 can be used as a scaffold to engineer RNA-binding proteins with designed sequence specificity. JF - Proceedings of the National Academy of Sciences of the United States of America AU - Cheong, Cheom-Gil AU - Hall, Traci M Tanaka AD - Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2006/09/12/ PY - 2006 DA - 2006 Sep 12 SP - 13635 EP - 13639 VL - 103 IS - 37 SN - 0027-8424, 0027-8424 KW - PUM1 protein, human KW - 0 KW - RNA, Messenger KW - RNA-Binding Proteins KW - Uracil KW - 56HH86ZVCT KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Adenine -- chemistry KW - Uracil -- chemistry KW - Humans KW - Repetitive Sequences, Amino Acid -- genetics KW - Mutation KW - Protein Engineering KW - RNA-Binding Proteins -- metabolism KW - RNA-Binding Proteins -- genetics KW - RNA, Messenger -- metabolism KW - RNA, Messenger -- chemistry KW - RNA-Binding Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68860417?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Engineering+RNA+sequence+specificity+of+Pumilio+repeats.&rft.au=Cheong%2C+Cheom-Gil%3BHall%2C+Traci+M+Tanaka&rft.aulast=Cheong&rft.aufirst=Cheom-Gil&rft.date=2006-09-12&rft.volume=103&rft.issue=37&rft.spage=13635&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-30 N1 - Date created - 2006-09-13 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Genes Dev. 1999 Oct 15;13(20):2704-12 [10541556] Neuron. 2004 Nov 18;44(4):663-76 [15541314] EMBO J. 2001 Feb 1;20(3):552-61 [11157761] J Biol Chem. 2001 Jan 19;276(3):1968-73 [11056173] EMBO J. 2001 Jan 15;20(1-2):178-86 [11226168] Cell. 2001 Apr 20;105(2):281-9 [11336677] Mol Cell. 2001 Apr;7(4):855-65 [11336708] J Biol Chem. 2001 Jun 15;276(24):20945-53 [11283000] RNA. 2001 Dec;7(12):1855-66 [11780640] Development. 2002 Jun;129(11):2699-710 [12015297] Nature. 2002 Jun 6;417(6889):660-3 [12050669] Cell. 2002 Aug 23;110(4):501-12 [12202039] Curr Biol. 2003 Feb 18;13(4):286-96 [12593794] IUBMB Life. 2003 Jul;55(7):359-66 [14584586] J Am Chem Soc. 2004 Jan 21;126(2):434-5 [14719918] Curr Biol. 2004 Feb 17;14(4):314-21 [14972682] Nat Biotechnol. 2004 May;22(5):535-46 [15122293] J Neurosci. 2004 Oct 6;24(40):8695-703 [15470135] Proc Natl Acad Sci U S A. 1986 Mar;83(6):1670-4 [2419912] Cell. 1986 Aug 29;46(5):659-67 [3488815] Nature. 1991 Jan 24;349(6307):346-8 [1702880] Development. 1992 Jan;114(1):221-32 [1576962] Genes Dev. 1992 Dec;6(12A):2312-26 [1459455] Cell. 1995 Mar 10;80(5):747-56 [7889568] Nature. 1996 Mar 14;380(6570):175-9 [8600395] Immunity. 1996 May;4(5):445-54 [8630730] J Biol Chem. 1997 Apr 25;272(17):10994-7 [9110988] Development. 1997 Jun;124(12):2463-76 [9199372] Proc Natl Acad Sci U S A. 1997 Oct 28;94(22):11887-92 [9342332] Nature. 1997 Dec 4;390(6659):477-84 [9393998] RNA. 1997 Dec;3(12):1421-33 [9404893] Development. 1998 Feb;125(4):679-90 [9435288] Nat Struct Biol. 1998 Jul;5(7):543-6 [9665165] Science. 1998 Aug 14;281(5379):1001-5 [9703499] Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9521-6 [10449725] Dev Cell. 2004 Nov;7(5):697-707 [15525531] Genomics. 2005 Jan;85(1):92-105 [15607425] Development. 2005 Aug;132(15):3471-81 [16000383] Nat Struct Mol Biol. 2005 Nov;12(11):945-51 [16244662] Nat Cell Biol. 1999 Nov;1(7):431-7 [10559987] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The impact of sex and contraceptive therapy on the plasma and intracellular pharmacokinetics of zidovudine. AN - 68828974; 16954724 AB - Zidovudine remains part of combination antiretroviral therapy. Pharmacological studies rely on quantitation of active triphosphates in peripheral blood mononuclear cells. This study evaluated the impact of female sex and contraceptive therapy on zidovudine plasma and intracellular pharmacokinetics and the impact of contraceptive therapy on HIV viral load. Serial plasma and intracellular zidovudine pharmacokinetics following oral and intravenous dosing were determined in 18 men and 20 women treated with zidovudine. Women could repeat pharmacokinetics assessment following 2 months oral or injectable contraceptive therapy. Zidovudine plasma and intracellular mono-, di- and triphosphate concentrations were determined by liquid chromatography tandem mass spectrometry. Plasma and cervical viral loads were determined preceding and following 2 months of contraceptive therapy in women. Men exhibited higher area under the concentration versus time curve for intracellular zidovudine and zidovudine-monophosphate following oral and intravenous dosing and higher zidovudine triphosphate following oral dosing. There was no difference between men and women in plasma zidovudine parameters. Furthermore, contraceptive therapy had no effect on zidovudine plasma or intracellular pharmacokinetics or on plasma or cervical HIV-1 RNA levels. Using an optimized pharmacokinetic design, this study indicated men exhibit significantly higher zidovudine-monophosphate and zidovudine-triphosphate exposure following zidovudine oral administration, having implications for drug toxicity and overall tolerance of zidovudine therapy. The lack of an effect of contraceptive therapy on zidovudine pharmacokinetics is surprising in light of previous pharmacokinetic studies for drugs eliminated primarily through glucuronidation. Contraceptive therapy had no effect on plasma or cervical viral load, results consistent with previous findings. JF - AIDS (London, England) AU - Aweeka, Francesca T AU - Rosenkranz, Susan L AU - Segal, Yoninah AU - Coombs, Robert W AU - Bardeguez, Arlene AU - Thevanayagam, Lourdes AU - Lizak, Patricia AU - Aberg, Judith AU - Watts, D Heather AU - NIAID AIDS Clinical Trials Group AD - Drug Research Unit, University of California, San Francisco, California 94143-0622, USA. faweeka@sfghsom.ucsf.edu ; NIAID AIDS Clinical Trials Group Y1 - 2006/09/11/ PY - 2006 DA - 2006 Sep 11 SP - 1833 EP - 1841 VL - 20 IS - 14 SN - 0269-9370, 0269-9370 KW - Contraceptive Agents, Female KW - 0 KW - Contraceptives, Oral, Combined KW - RNA, Viral KW - Reverse Transcriptase Inhibitors KW - Zidovudine KW - 4B9XT59T7S KW - Norinyl KW - 8015-29-0 KW - Mestranol KW - B2V233XGE7 KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Norethindrone KW - T18F433X4S KW - Index Medicus KW - AIDS/HIV KW - Administration, Oral KW - Contraceptives, Oral, Combined -- administration & dosage KW - Sex Factors KW - Norethindrone -- administration & dosage KW - Humans KW - Injections, Intramuscular KW - Viral Load KW - Drug Therapy, Combination KW - Adult KW - Middle Aged KW - Medroxyprogesterone Acetate -- administration & dosage KW - HIV-1 -- drug effects KW - Mestranol -- administration & dosage KW - Female KW - Male KW - RNA, Viral -- analysis KW - Zidovudine -- therapeutic use KW - Zidovudine -- pharmacokinetics KW - Reverse Transcriptase Inhibitors -- pharmacokinetics KW - Zidovudine -- blood KW - Reverse Transcriptase Inhibitors -- blood KW - Contraceptive Agents, Female -- administration & dosage KW - Reverse Transcriptase Inhibitors -- therapeutic use KW - HIV Seropositivity -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68828974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=The+impact+of+sex+and+contraceptive+therapy+on+the+plasma+and+intracellular+pharmacokinetics+of+zidovudine.&rft.au=Aweeka%2C+Francesca+T%3BRosenkranz%2C+Susan+L%3BSegal%2C+Yoninah%3BCoombs%2C+Robert+W%3BBardeguez%2C+Arlene%3BThevanayagam%2C+Lourdes%3BLizak%2C+Patricia%3BAberg%2C+Judith%3BWatts%2C+D+Heather%3BNIAID+AIDS+Clinical+Trials+Group&rft.aulast=Aweeka&rft.aufirst=Francesca&rft.date=2006-09-11&rft.volume=20&rft.issue=14&rft.spage=1833&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-05 N1 - Date created - 2006-09-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - A Whole-Genome View of Microbial Signal Transduction T2 - 159th Meeting of the Society for General Microbiology AN - 40424833; 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4361943 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Sigano, Dina M AU - Malolanarasimhan, Krishnan AU - Kedei, Noemi AU - Lewin, Nancy E AU - Blumberg, Peter M AU - Marquez, Victor E Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Membranes KW - Protein kinase C KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287245?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Targeting+Protein+Kinase+C+%28PKC%29+to+Specific+Cellular+Membrane+Domains+with+the+use+of+DAG-Lactones+Containing+Rigid+Oligo%28P-Phenylene+Ethynylene%29+Acyl+Units&rft.au=Sigano%2C+Dina+M%3BMalolanarasimhan%2C+Krishnan%3BKedei%2C+Noemi%3BLewin%2C+Nancy+E%3BBlumberg%2C+Peter+M%3BMarquez%2C+Victor+E&rft.aulast=Sigano&rft.aufirst=Dina&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of New Multi-Scale Methods for Examining Macromolecular Systems T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39285593; 4359405 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Brooks, Bernard R AU - Zheng, Wenjun Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Macromolecules KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39285593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Development+of+New+Multi-Scale+Methods+for+Examining+Macromolecular+Systems&rft.au=Brooks%2C+Bernard+R%3BZheng%2C+Wenjun&rft.aulast=Brooks&rft.aufirst=Bernard&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Conformational Energy of Bioactive Ligand-Protein Complexes T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39285250; 4359297 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Weidlich, Iwona E AU - Nicklaus, Marc C Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Energy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39285250?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Conformational+Energy+of+Bioactive+Ligand-Protein+Complexes&rft.au=Weidlich%2C+Iwona+E%3BNicklaus%2C+Marc+C&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bi-Directional, Iterative Approach to the Structural Determination of the Binding Site of Anti-Diabetic Drugs at GPR40 T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39278854; 4359220 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Tikhonova, Irina AU - Sum, Chi Shing AU - Childress, John AU - Neumann, Susanne AU - Thomas, Craig J AU - Raaka, Bruce M AU - Costanzi, Stefano AU - Gershengorn, Marvin C Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Drugs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39278854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Bi-Directional%2C+Iterative+Approach+to+the+Structural+Determination+of+the+Binding+Site+of+Anti-Diabetic+Drugs+at+GPR40&rft.au=Tikhonova%2C+Irina%3BSum%2C+Chi+Shing%3BChildress%2C+John%3BNeumann%2C+Susanne%3BThomas%2C+Craig+J%3BRaaka%2C+Bruce+M%3BCostanzi%2C+Stefano%3BGershengorn%2C+Marvin+C&rft.aulast=Tikhonova&rft.aufirst=Irina&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Selectively Non-Selective Drugs ("Magic Shotguns") vs. Selective Drugs ("Magic Bullets") for CNS Disorders T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39271111; 4362031 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Roth, Bryan L Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Drugs KW - Central nervous system KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39271111?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Selectively+Non-Selective+Drugs+%28%22Magic+Shotguns%22%29+vs.+Selective+Drugs+%28%22Magic+Bullets%22%29+for+CNS+Disorders&rft.au=Roth%2C+Bryan+L&rft.aulast=Roth&rft.aufirst=Bryan&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Hydrazone Amides as Novel Peptoid Surrogates for Expedited Library Synthesis: Application to the Preparation of TSG101-Directed HIV-1 Budding Antagonists T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39270981; 4362012 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Liu, Fa AU - Stephen, Andrew G AU - Adamson, Catherine AU - Freed, Eric O AU - Fisher, Robert J AU - Burke, Terrence R Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Amides KW - Budding KW - Antagonists KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270981?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Hydrazone+Amides+as+Novel+Peptoid+Surrogates+for+Expedited+Library+Synthesis%3A+Application+to+the+Preparation+of+TSG101-Directed+HIV-1+Budding+Antagonists&rft.au=Liu%2C+Fa%3BStephen%2C+Andrew+G%3BAdamson%2C+Catherine%3BFreed%2C+Eric+O%3BFisher%2C+Robert+J%3BBurke%2C+Terrence+R&rft.aulast=Liu&rft.aufirst=Fa&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and Application of CHARMM's Hybrid QM/MM Reaction Path Methods T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39270272; 4359166 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Woodcock, H Lee AU - Brooks, Bernard R Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Hybrids KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39270272?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Development+and+Application+of+CHARMM%27s+Hybrid+QM%2FMM+Reaction+Path+Methods&rft.au=Woodcock%2C+H+Lee%3BBrooks%2C+Bernard+R&rft.aulast=Woodcock&rft.aufirst=H&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Site-Directed Mutagenesis of the C1b Domain of Protein Kinase C (PKC) Delta Provides a Unique Platform for the Development of Selective Ligands for the Atypical PKC Zeta T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39268283; 4361949 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Kang, Ji-Hye AU - Peach, Megan L AU - Pu, Yongmei AU - Blumberg, Peter M AU - Marquez, Victor E Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Protein kinase C KW - Site-directed mutagenesis KW - Mutagenesis KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39268283?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Site-Directed+Mutagenesis+of+the+C1b+Domain+of+Protein+Kinase+C+%28PKC%29+Delta+Provides+a+Unique+Platform+for+the+Development+of+Selective+Ligands+for+the+Atypical+PKC+Zeta&rft.au=Kang%2C+Ji-Hye%3BPeach%2C+Megan+L%3BPu%2C+Yongmei%3BBlumberg%2C+Peter+M%3BMarquez%2C+Victor+E&rft.aulast=Kang&rft.aufirst=Ji-Hye&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Synthesis of 5-Nitroimidazole Derivatives of Tert-Butyl Ester of Aminoacids T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39268231; 4361926 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Weidlich, Iwona E AU - Sobiak, Stanislaw Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Esters KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39268231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Synthesis+of+5-Nitroimidazole+Derivatives+of+Tert-Butyl+Ester+of+Aminoacids&rft.au=Weidlich%2C+Iwona+E%3BSobiak%2C+Stanislaw&rft.aulast=Weidlich&rft.aufirst=Iwona&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NMR for Detection of Lipid Rafts T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39263526; 4362599 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Polozov, Ivan V AU - Gawrisch, Klaus AU - Zimmerberg, Joshua Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - N.M.R. KW - Lipid rafts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263526?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=NMR+for+Detection+of+Lipid+Rafts&rft.au=Polozov%2C+Ivan+V%3BGawrisch%2C+Klaus%3BZimmerberg%2C+Joshua&rft.aulast=Polozov&rft.aufirst=Ivan&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Towards Understanding the Organization of Membrane Protein Microdomains in Cells T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39263385; 4362561 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Zimmerberg, Joshua Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Membrane proteins KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39263385?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Towards+Understanding+the+Organization+of+Membrane+Protein+Microdomains+in+Cells&rft.au=Zimmerberg%2C+Joshua&rft.aulast=Zimmerberg&rft.aufirst=Joshua&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Metal-Induced Carcinogenesis: The Role of Ascorbate T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39258366; 4362444 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Salnikow, Konstantin Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Carcinogenesis KW - Ascorbic acid KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39258366?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Metal-Induced+Carcinogenesis%3A+The+Role+of+Ascorbate&rft.au=Salnikow%2C+Konstantin&rft.aulast=Salnikow&rft.aufirst=Konstantin&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mechanism-Based Tuning of the Desired Properties of Biomimetics: (Salen)Mn Biomimetic Compounds as Therapeutic Agents and Synthetic Catalysts T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39255181; 4359320 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Abashkin, Yuri G AU - Burt, Stanley K Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Catalysts KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39255181?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Mechanism-Based+Tuning+of+the+Desired+Properties+of+Biomimetics%3A+%28Salen%29Mn+Biomimetic+Compounds+as+Therapeutic+Agents+and+Synthetic+Catalysts&rft.au=Abashkin%2C+Yuri+G%3BBurt%2C+Stanley+K&rft.aulast=Abashkin&rft.aufirst=Yuri&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Molecular Modeling Study of TRH-R1 and TRH-R2 T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39254008; 4359329 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Deflorian, Francesca AU - Costanzi, Stefano AU - Neumann, Susanne AU - Engel, Stanislav AU - Jiang, Jian-Kang AU - Thomas, Craig J AU - Raaka, Bruce M AU - Gershengorn, Marvin C Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Molecular modelling KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39254008?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Molecular+Modeling+Study+of+TRH-R1+and+TRH-R2&rft.au=Deflorian%2C+Francesca%3BCostanzi%2C+Stefano%3BNeumann%2C+Susanne%3BEngel%2C+Stanislav%3BJiang%2C+Jian-Kang%3BThomas%2C+Craig+J%3BRaaka%2C+Bruce+M%3BGershengorn%2C+Marvin+C&rft.aulast=Deflorian&rft.aufirst=Francesca&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of a Novel Carbohydrate Microarray and its Application in Cancer Diagnostics and Therapeutics T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39249151; 4361823 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Manimala, Joseph C AU - Roach, Tim AU - Li, Zhitao AU - Gildersleeve, Jeffrey C Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Carbohydrates KW - Cancer KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39249151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Development+of+a+Novel+Carbohydrate+Microarray+and+its+Application+in+Cancer+Diagnostics+and+Therapeutics&rft.au=Manimala%2C+Joseph+C%3BRoach%2C+Tim%3BLi%2C+Zhitao%3BGildersleeve%2C+Jeffrey+C&rft.aulast=Manimala&rft.aufirst=Joseph&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blocking HIV-1 Entry and other Lessons Learned from Novel Cyanobacterial Proteins T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39246551; 4358501 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Bewley, Carole A AU - Hussan, Syed AU - Williams, David AU - Cai, Mengli Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Blocking+HIV-1+Entry+and+other+Lessons+Learned+from+Novel+Cyanobacterial+Proteins&rft.au=Bewley%2C+Carole+A%3BHussan%2C+Syed%3BWilliams%2C+David%3BCai%2C+Mengli&rft.aulast=Bewley&rft.aufirst=Carole&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure and Dynamics of Polyunsaturated Hydrocarbon Chains in Lipid Bilayers and their Interaction with G-Protein Coupled Membrane Receptors T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39246158; 4362583 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Gawrisch, Klaus AU - Soubias, Olivier AU - Eldho, Nadukkudy V AU - Teague, Walter E AU - Feller, Scott E Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Lipid bilayers KW - Hydrocarbons KW - Membranes KW - Guanine nucleotide-binding protein KW - Polyunsaturated hydrocarbons KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39246158?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Structure+and+Dynamics+of+Polyunsaturated+Hydrocarbon+Chains+in+Lipid+Bilayers+and+their+Interaction+with+G-Protein+Coupled+Membrane+Receptors&rft.au=Gawrisch%2C+Klaus%3BSoubias%2C+Olivier%3BEldho%2C+Nadukkudy+V%3BTeague%2C+Walter+E%3BFeller%2C+Scott+E&rft.aulast=Gawrisch&rft.aufirst=Klaus&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Nanoporous Anodic Aluminum Oxide as Substrate for Functional Reconstitution of G-Protein Coupled Membrane Receptors T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39245796; 4357467 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Gawrisch, Klaus AU - Soubias, Olivier AU - Yeliseev, Alexei A AU - Gaede, Holly C AU - Polozov, Ivan V AU - Teague, Walter E Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Aluminum KW - Membranes KW - Aluminum oxide KW - Guanine nucleotide-binding protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39245796?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Nanoporous+Anodic+Aluminum+Oxide+as+Substrate+for+Functional+Reconstitution+of+G-Protein+Coupled+Membrane+Receptors&rft.au=Gawrisch%2C+Klaus%3BSoubias%2C+Olivier%3BYeliseev%2C+Alexei+A%3BGaede%2C+Holly+C%3BPolozov%2C+Ivan+V%3BTeague%2C+Walter+E&rft.aulast=Gawrisch&rft.aufirst=Klaus&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Binding Sites Identification of Abeta-Amyloid Plaques in Alzheimer's Disease Based on Small Molecule Ligands T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39245230; 4362277 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Cai, Lisheng AU - Innis, Robert B AU - Pike, Victor W Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Plaques KW - Ligands KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39245230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Binding+Sites+Identification+of+Abeta-Amyloid+Plaques+in+Alzheimer%27s+Disease+Based+on+Small+Molecule+Ligands&rft.au=Cai%2C+Lisheng%3BInnis%2C+Robert+B%3BPike%2C+Victor+W&rft.aulast=Cai&rft.aufirst=Lisheng&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - In Vivo Imaging of Oxygen using Overhauser Enhanced MRI: Applications to Small Animal Imaging Research and Clinical Oncology T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39240623; 4359785 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Cherukuri, Murali Krishna AU - Subramanian, Sankaran AU - Mitchell, James B Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Oxygen KW - Oncology KW - Magnetic resonance imaging KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=In+Vivo+Imaging+of+Oxygen+using+Overhauser+Enhanced+MRI%3A+Applications+to+Small+Animal+Imaging+Research+and+Clinical+Oncology&rft.au=Cherukuri%2C+Murali+Krishna%3BSubramanian%2C+Sankaran%3BMitchell%2C+James+B&rft.aulast=Cherukuri&rft.aufirst=Murali&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Applications of RNAi Against Cancer-Associated Genes T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39234074; 4361813 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Martin, Scott E AU - Jones, Tamara L AU - Caplen, Natasha J Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - RNA-mediated interference KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39234074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Applications+of+RNAi+Against+Cancer-Associated+Genes&rft.au=Martin%2C+Scott+E%3BJones%2C+Tamara+L%3BCaplen%2C+Natasha+J&rft.aulast=Martin&rft.aufirst=Scott&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Design of Glutathione Transferase-Activated Nitric Oxide-Releasing Prodrugs as Anticancer Agents T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39233811; 4361799 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Wilde, Thomas C AU - Showalter, Brett M AU - Saavedra, Joseph E AU - Shami, Paul J AU - Tew, Kenneth D AU - Townsend, Danyelle M AU - Ji, Xinhua AU - Keefer, Larry K Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Antitumor agents KW - Glutathione KW - Prodrugs KW - Coenzymes KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39233811?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Design+of+Glutathione+Transferase-Activated+Nitric+Oxide-Releasing+Prodrugs+as+Anticancer+Agents&rft.au=Wilde%2C+Thomas+C%3BShowalter%2C+Brett+M%3BSaavedra%2C+Joseph+E%3BShami%2C+Paul+J%3BTew%2C+Kenneth+D%3BTownsend%2C+Danyelle+M%3BJi%2C+Xinhua%3BKeefer%2C+Larry+K&rft.aulast=Wilde&rft.aufirst=Thomas&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Theory of the Statistics of Kinetic Transitions T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39233270; 4362843 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Gopich, Irina AU - Szabo, Attila Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Kinetics KW - Statistics KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39233270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Theory+of+the+Statistics+of+Kinetic+Transitions&rft.au=Gopich%2C+Irina%3BSzabo%2C+Attila&rft.aulast=Gopich&rft.aufirst=Irina&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure Activity Relationship of Uridine 5'Diphosphoglucose (UDP-Glucose) Analogs at the Human P2Y sub(14) Receptor T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39232778; 4362219 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Ko, Hyojin AU - Fricks, Ingrid AU - Ivanov, Andrei A AU - Harden, T Kendall AU - Jacobson, Kenneth A Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Uridine KW - Purine P2Y receptors KW - Analogs KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39232778?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Structure+Activity+Relationship+of+Uridine+5%27Diphosphoglucose+%28UDP-Glucose%29+Analogs+at+the+Human+P2Y+sub%2814%29+Receptor&rft.au=Ko%2C+Hyojin%3BFricks%2C+Ingrid%3BIvanov%2C+Andrei+A%3BHarden%2C+T+Kendall%3BJacobson%2C+Kenneth+A&rft.aulast=Ko&rft.aufirst=Hyojin&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Normalizing Ionic Resonance Structures T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39231031; 4356944 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Sitzmann, Markus AU - Ihlenfeldt, Wolf-Dietrich AU - Nicklaus, Marc C Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Resonance KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39231031?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Normalizing+Ionic+Resonance+Structures&rft.au=Sitzmann%2C+Markus%3BIhlenfeldt%2C+Wolf-Dietrich%3BNicklaus%2C+Marc+C&rft.aulast=Sitzmann&rft.aufirst=Markus&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Parallel Synthesis and High-throughput Solubility Determination of NCGC Produced Libraries: Models for Probe Development T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39226319; 4361946 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Nelson, Michael E AU - Padia, Janak K AU - Zuck, Karina M AU - Inglese, James AU - Austin, Christopher P Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Probes KW - Solubility KW - Models KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39226319?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Parallel+Synthesis+and+High-throughput+Solubility+Determination+of+NCGC+Produced+Libraries%3A+Models+for+Probe+Development&rft.au=Nelson%2C+Michael+E%3BPadia%2C+Janak+K%3BZuck%2C+Karina+M%3BInglese%2C+James%3BAustin%2C+Christopher+P&rft.aulast=Nelson&rft.aufirst=Michael&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structural Studies of Biologically Interesting Fluorinated Nucleosides T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39222970; 4358546 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Barchi Jr, Joseph J Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Nucleosides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39222970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Structural+Studies+of+Biologically+Interesting+Fluorinated+Nucleosides&rft.au=Barchi+Jr%2C+Joseph+J&rft.aulast=Barchi+Jr&rft.aufirst=Joseph&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Homology Modeling and Molecular Dynamics Simulations of BRCA1 BRCT Domain Bound to p53 T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39222629; 4359049 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Liu, Jin AU - Nussinov, Ruth Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Simulation KW - P53 protein KW - Homology KW - BRCA1 protein KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39222629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Homology+Modeling+and+Molecular+Dynamics+Simulations+of+BRCA1+BRCT+Domain+Bound+to+p53&rft.au=Liu%2C+Jin%3BNussinov%2C+Ruth&rft.aulast=Liu&rft.aufirst=Jin&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Probing Mu Transposition Target Complex via Single-Molecule TIRFM and 2P-FCS T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39221320; 4355738 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Tan, Xin AU - Mizuuchi, Michiyo AU - Mizuuchi, Kiyoshi Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Transposition KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39221320?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Probing+Mu+Transposition+Target+Complex+via+Single-Molecule+TIRFM+and+2P-FCS&rft.au=Tan%2C+Xin%3BMizuuchi%2C+Michiyo%3BMizuuchi%2C+Kiyoshi&rft.aulast=Tan&rft.aufirst=Xin&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intramural Research at the National Center for Biotechnology Information T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39218276; 4357010 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Bolton, Evan Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Biotechnology KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39218276?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Intramural+Research+at+the+National+Center+for+Biotechnology+Information&rft.au=Bolton%2C+Evan&rft.aulast=Bolton&rft.aufirst=Evan&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Peer Review at the National Institutes of Health T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39218232; 4357009 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Chacko, George Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Reviews KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39218232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Peer+Review+at+the+National+Institutes+of+Health&rft.au=Chacko%2C+George&rft.aulast=Chacko&rft.aufirst=George&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Rapid Structure Lookup and Distributed Substructure Searches in Very Large Databases T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39218013; 4356928 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Nicklaus, Marc C AU - Sitzmann, Markus AU - Filippov, Igor V AU - Ihlenfeldt, Wolf-Dietrich Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Databases KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39218013?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Rapid+Structure+Lookup+and+Distributed+Substructure+Searches+in+Very+Large+Databases&rft.au=Nicklaus%2C+Marc+C%3BSitzmann%2C+Markus%3BFilippov%2C+Igor+V%3BIhlenfeldt%2C+Wolf-Dietrich&rft.aulast=Nicklaus&rft.aufirst=Marc&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Advances in NMR Over a Half-Century T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39217191; 4354976 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Becker, Edwin D Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - N.M.R. KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39217191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Advances+in+NMR+Over+a+Half-Century&rft.au=Becker%2C+Edwin+D&rft.aulast=Becker&rft.aufirst=Edwin&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - MDM2 Inhibitory Peptides: Side Chains Cyclization as a Method of Stabilization of the Biologically Active Helical Conformation T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39214967; 4361864 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Krajewski, Krzysztof AU - Nikolovska-Coleska, Zaneta AU - Wang, Shaomeng AU - Roller, Peter P Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Conformation KW - MDM2 protein KW - Stabilizing KW - Peptides KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39214967?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=MDM2+Inhibitory+Peptides%3A+Side+Chains+Cyclization+as+a+Method+of+Stabilization+of+the+Biologically+Active+Helical+Conformation&rft.au=Krajewski%2C+Krzysztof%3BNikolovska-Coleska%2C+Zaneta%3BWang%2C+Shaomeng%3BRoller%2C+Peter+P&rft.aulast=Krajewski&rft.aufirst=Krzysztof&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Electrostatic and Solvent-Structure Forces in Molecular Interactions: Competition of Forces in Solution and Semi-Continuum Representation of Solvent-Induced Forces T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39214958; 4359014 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Hassan, Sergio A Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Competition KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39214958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Electrostatic+and+Solvent-Structure+Forces+in+Molecular+Interactions%3A+Competition+of+Forces+in+Solution+and+Semi-Continuum+Representation+of+Solvent-Induced+Forces&rft.au=Hassan%2C+Sergio+A&rft.aulast=Hassan&rft.aufirst=Sergio&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Structure-Activity Relationships of 2, N super(6), 5'-Substituted Adenosine Derivatives as Human A sub(2B) Adenosine Receptor Agonists T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39213301; 4362218 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Adachi, Hayamitsu AU - Palaniappan, Krishnan K AU - Gao, Zhan-Guo AU - Jacobson, Kenneth A Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Adenosine receptors KW - Structure-activity relationships KW - Metabolites KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39213301?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Structure-Activity+Relationships+of+2%2C+N+super%286%29%2C+5%27-Substituted+Adenosine+Derivatives+as+Human+A+sub%282B%29+Adenosine+Receptor+Agonists&rft.au=Adachi%2C+Hayamitsu%3BPalaniappan%2C+Krishnan+K%3BGao%2C+Zhan-Guo%3BJacobson%2C+Kenneth+A&rft.aulast=Adachi&rft.aufirst=Hayamitsu&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comprehensive Analysis of the Swelling and Biomechanical Properties of Tissue Engineered Cartilage T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39213268; 4356829 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Horkay, Ferenc AU - Lin, David C AU - Dimitriadis, Emilios K AU - Horkayne-Szakaly, Iren AU - Basser, Peter J Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Biomechanics KW - Mechanical properties KW - Cartilage KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39213268?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Comprehensive+Analysis+of+the+Swelling+and+Biomechanical+Properties+of+Tissue+Engineered+Cartilage&rft.au=Horkay%2C+Ferenc%3BLin%2C+David+C%3BDimitriadis%2C+Emilios+K%3BHorkayne-Szakaly%2C+Iren%3BBasser%2C+Peter+J&rft.aulast=Horkay&rft.aufirst=Ferenc&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pubchem: An Information Resource Linking Chemistry and Biology T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39209419; 4356898 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Bolton, Evan Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Education KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39209419?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Pubchem%3A+An+Information+Resource+Linking+Chemistry+and+Biology&rft.au=Bolton%2C+Evan&rft.aulast=Bolton&rft.aufirst=Evan&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Weak Alignment: A New Dimension in NMR T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39207575; 4354979 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Bax, Ad Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - N.M.R. KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39207575?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Weak+Alignment%3A+A+New+Dimension+in+NMR&rft.au=Bax%2C+Ad&rft.aulast=Bax&rft.aufirst=Ad&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Intrinsic Rates and Activation Free Energies from Single-Molecule Pulling Experiments T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39206851; 4355464 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Dudko, Olga K AU - Hummer, Gerhard AU - Szabo, Attila Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Free energy KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39206851?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Intrinsic+Rates+and+Activation+Free+Energies+from+Single-Molecule+Pulling+Experiments&rft.au=Dudko%2C+Olga+K%3BHummer%2C+Gerhard%3BSzabo%2C+Attila&rft.aulast=Dudko&rft.aufirst=Olga&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deciphering Protein Turnover, Topology and Transport in Living Cells T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39205054; 4362562 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Lippincott-Schwartz, Jennifer Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Protein turnover KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39205054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Deciphering+Protein+Turnover%2C+Topology+and+Transport+in+Living+Cells&rft.au=Lippincott-Schwartz%2C+Jennifer&rft.aulast=Lippincott-Schwartz&rft.aufirst=Jennifer&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Click Chemistry-Derived Biotin-Tagged Diketo Acid-Containing Biphenyl Ketones Designed as HIV-1 Integrase Photoaffinity Ligands T2 - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AN - 39200107; 4362017 JF - 2006 Meeting and Exposition of the American Chemical Society (ACS 06) AU - Zhao, Xue Zhi AU - Semenova, Elena A AU - Johnson, Allison AU - Marchand, Christophe AU - Liao, Chenzhong AU - Nicklaus, Marc C AU - Pommier, Yves AU - Burke Jr, Terrence R Y1 - 2006/09/10/ PY - 2006 DA - 2006 Sep 10 KW - Ketones KW - Integrase KW - Biphenyl KW - Ligands KW - Human immunodeficiency virus 1 KW - U 7000:Multidisciplinary UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39200107?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.atitle=Click+Chemistry-Derived+Biotin-Tagged+Diketo+Acid-Containing+Biphenyl+Ketones+Designed+as+HIV-1+Integrase+Photoaffinity+Ligands&rft.au=Zhao%2C+Xue+Zhi%3BSemenova%2C+Elena+A%3BJohnson%2C+Allison%3BMarchand%2C+Christophe%3BLiao%2C+Chenzhong%3BNicklaus%2C+Marc+C%3BPommier%2C+Yves%3BBurke+Jr%2C+Terrence+R&rft.aulast=Zhao&rft.aufirst=Xue&rft.date=2006-09-10&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meeting+and+Exposition+of+the+American+Chemical+Society+%28ACS+06%29&rft.issn=&rft_id=info:doi/ L2 - http://oasys.acs.org/acs/232nm/techprogram/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cytochrome P450 2A6 polymorphism in nasopharyngeal carcinoma. AN - 69005388; 16377082 AB - Nitrosamine has been identified as a carcinogen for nasopharyngeal carcinoma (NPC). Here, we investigated if a nitrosamine metabolizing gene, cytochrome P450 2A6 (CYP2A6) played an important role in NPC development. Relationships between the disease and the CYP2A6 were studied in 74 NPC patients and 137 age-matched healthy controls by using PCR-RFLP assay to distinguish between a wide type allele, *1A, and two mutant alleles, *1B and *4C. Overall, a significant association between CYP2A6 polymorphism and NPC development was observed (P<0.05). Individual with mutant alleles had an increased risk for NPC when compared to those with *1A/*1A (OR=2.37, 95% CI=1.27-4.46). In addition, males who carried mutant alleles of CYP2A6 had a fivefold increased risk for NPC when compared with those who carried *1A/*1A genotype (OR=5.02, 95% CI=1.82-14.14). It is thus suggested that CYP2A6 polymorphism may play a crucial role in NPC susceptibility and it may be used as a risk marker for NPC. JF - Cancer letters AU - Tiwawech, Danai AU - Srivatanakul, Petcharin AU - Karalak, Anant AU - Ishida, Takafumi AD - Research Division, National Cancer Institute, Bangkok 10400, Thailand. Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 SP - 135 EP - 141 VL - 241 IS - 1 SN - 0304-3835, 0304-3835 KW - Mixed Function Oxygenases KW - EC 1.- KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2A6 protein, human KW - Cytochrome P-450 CYP2A6 KW - Index Medicus KW - Genotype KW - Polymerase Chain Reaction KW - Polymorphism, Restriction Fragment Length KW - Aged, 80 and over KW - Humans KW - Adult KW - Aged KW - Middle Aged KW - Male KW - Female KW - Nasopharyngeal Neoplasms -- enzymology KW - Polymorphism, Genetic KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Nasopharyngeal Neoplasms -- genetics KW - Mixed Function Oxygenases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69005388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Cytochrome+P450+2A6+polymorphism+in+nasopharyngeal+carcinoma.&rft.au=Tiwawech%2C+Danai%3BSrivatanakul%2C+Petcharin%3BKaralak%2C+Anant%3BIshida%2C+Takafumi&rft.aulast=Tiwawech&rft.aufirst=Danai&rft.date=2006-09-08&rft.volume=241&rft.issue=1&rft.spage=135&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Superoxide fluxes limit nitric oxide-induced signaling. AN - 68820755; 16829532 AB - Independently, superoxide (O2-) and nitric oxide (NO) are biologically important signaling molecules. When co-generated, these radicals react rapidly to form powerful oxidizing and nitrating intermediates. Although this reaction was once thought to be solely cytotoxic, herein we demonstrate using MCF7, macrophage, and endothelial cells that when nanomolar levels of NO and O2- were produced concomitantly, the effective NO concentration was established by the relative fluxes of these two radicals. Differential regulation of sGC, pERK, HIF-1alpha, and p53 were used as biological dosimeters for NO concentration. Introduction of intracellular- or extracellular-generated O2- during NO generation resulted in a concomitant increase in oxidative intermediates with a decrease in steady-state NO concentrations and a proportional reduction in the levels of sGC, ERK, HIF-1alpha, and p53 regulation. NO responses were restored by addition of SOD. The intermediates formed from the reactions of NO with O2- were non-toxic, did not form 3-nitrotyrosine, nor did they elicit any signal transduction responses. H2O2 in bolus or generated from the dismutation of O2- by SOD, was cytotoxic at high concentrations and activated p53 independent of NO. This effect was completely inhibited by catalase, suppressed by NO, and exacerbated by intracellular catalase inhibition. We conclude that the reaction of O2- with NO is an important regulatory mechanism, which modulates signaling pathways by limiting steady-state levels of NO and preventing H2O2 formation from O2-. JF - The Journal of biological chemistry AU - Thomas, Douglas D AU - Ridnour, Lisa A AU - Espey, Michael Graham AU - Donzelli, Sonia AU - Ambs, Stefan AU - Hussain, S Perwez AU - Harris, Curtis C AU - DeGraff, William AU - Roberts, David D AU - Mitchell, James B AU - Wink, David A AD - Tumor Biology Section, Radiation Biology Branch, National Institutes of Health, Bethesda, MD 20892, USA. thomasdo@mail.nih.gov Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 SP - 25984 EP - 25993 VL - 281 IS - 36 SN - 0021-9258, 0021-9258 KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - 0 KW - Oxidants KW - Tumor Suppressor Protein p53 KW - Superoxides KW - 11062-77-4 KW - Nitric Oxide KW - 31C4KY9ESH KW - Hydrogen Peroxide KW - BBX060AN9V KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Macrophages -- cytology KW - Animals KW - Coculture Techniques KW - Humans KW - Hydrogen Peroxide -- metabolism KW - Superoxide Dismutase -- metabolism KW - Hypoxia-Inducible Factor 1, alpha Subunit -- metabolism KW - Tumor Suppressor Protein p53 -- metabolism KW - Oxidation-Reduction KW - Cattle KW - Endothelial Cells -- cytology KW - Oxidants -- metabolism KW - Gene Expression Regulation KW - Cell Line KW - Endothelial Cells -- metabolism KW - Macrophages -- metabolism KW - Superoxides -- metabolism KW - Second Messenger Systems -- physiology KW - Nitric Oxide -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68820755?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Superoxide+fluxes+limit+nitric+oxide-induced+signaling.&rft.au=Thomas%2C+Douglas+D%3BRidnour%2C+Lisa+A%3BEspey%2C+Michael+Graham%3BDonzelli%2C+Sonia%3BAmbs%2C+Stefan%3BHussain%2C+S+Perwez%3BHarris%2C+Curtis+C%3BDeGraff%2C+William%3BRoberts%2C+David+D%3BMitchell%2C+James+B%3BWink%2C+David+A&rft.aulast=Thomas&rft.aufirst=Douglas&rft.date=2006-09-08&rft.volume=281&rft.issue=36&rft.spage=25984&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-18 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chromosomal translocations involving the MLL gene: molecular mechanisms. AN - 68811855; 16797254 AB - A wide array of recurrent, non-random chromosomal translocations are associated with hematologic malignancies; experimental models have clearly demonstrated that many of these translocations are causal events during malignant transformation. Translocations involving the MLL gene are among the most common of these non-random translocations. Leukemias with MLL translocations have been the topic of intense interest because of the unusual, biphenotypic immunophenotype of these leukemias, because of the unique clinical presentation of some MLL translocations (infant leukemia and therapy-related leukemia), and because of the large number of different chromosomal loci that partner with MLL in these translocations. This review is focused on the potential mechanisms that lead to MLL translocations, and will discuss aberrant VDJ recombination, Alu-mediated recombination, non-homologous end joining, as well as the effect of DNA topoisomerase II poisons and chromatin structure. JF - DNA repair AU - Aplan, Peter D AD - Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Bldg. 8 Rm. 5101, 8901 Rockville Pike, Bethesda, MD 20889, USA. aplanp@mail.nih.gov Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 SP - 1265 EP - 1272 VL - 5 IS - 9-10 SN - 1568-7864, 1568-7864 KW - Chromatin KW - 0 KW - MLL protein, human KW - Topoisomerase II Inhibitors KW - Myeloid-Lymphoid Leukemia Protein KW - 149025-06-9 KW - Histone-Lysine N-Methyltransferase KW - EC 2.1.1.43 KW - Index Medicus KW - Infant KW - Base Sequence KW - Models, Genetic KW - Humans KW - Recombination, Genetic KW - Molecular Sequence Data KW - Myeloid-Lymphoid Leukemia Protein -- genetics KW - Leukemia, Myeloid, Acute -- genetics KW - Chromatin -- chemistry KW - Leukemia, Myeloid, Acute -- chemically induced KW - Translocation, Genetic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68811855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=DNA+repair&rft.atitle=Chromosomal+translocations+involving+the+MLL+gene%3A+molecular+mechanisms.&rft.au=Aplan%2C+Peter+D&rft.aulast=Aplan&rft.aufirst=Peter&rft.date=2006-09-08&rft.volume=5&rft.issue=9-10&rft.spage=1265&rft.isbn=&rft.btitle=&rft.title=DNA+repair&rft.issn=15687864&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-09-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Oncogene. 1998 Dec 10;17(23):3035-44 [9881706] J Clin Oncol. 1999 Jan;17(1):191-6 [10458233] Cancer Res. 1999 Aug 15;59(16):4095-9 [10463613] Mol Cell Biol. 1999 Oct;19(10):7050-60 [10490642] Curr Opin Hematol. 2005 Jan;12(1):1-6 [15604884] Oncogene. 2003 Nov 20;22(52):8448-59 [14627986] Blood. 2005 Mar 1;105(5):2124-31 [15528316] Mol Cell. 2005 Mar 18;17(6):885-94 [15780943] Semin Cancer Biol. 2005 Jun;15(3):175-88 [15826832] Trends Genet. 2006 Jan;22(1):46-55 [16257470] Blood. 2006 Jun 15;107(12):4663-5 [16478880] Int J Hematol. 2003 Dec;78(5):390-401 [14704031] Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2797-802 [10688900] Genes Chromosomes Cancer. 2000 Oct;29(2):96-105 [10959088] J Cell Biochem Suppl. 2000;Suppl 35:3-22 [11389527] Oncogene. 2001 May 24;20(23):2900-7 [11420702] Nature. 2001 Jul 12;412(6843):133-5 [11449252] Nature. 2001 Jul 12;412(6843):198-202 [11449278] Nature. 2001 Jul 12;412(6843):202-6 [11449279] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11592-7 [11553769] Oncogene. 2001 Sep 10;20(40):5763-77 [11607826] Hum Mol Genet. 2001 Oct 15;10(22):2481-91 [11709535] Apoptosis. 2002 Apr;7(2):173-7 [11865202] Nat Rev Cancer. 2001 Dec;1(3):245-50 [11902580] Cancer Cell. 2002 Feb;1(1):63-74 [12086889] Cancer Cell. 2002 Jun;1(5):417-20 [12124171] Genes Chromosomes Cancer. 2002 Oct;35(2):97-112 [12203773] N Engl J Med. 2002 Nov 14;347(20):1593-603 [12432047] Genes Chromosomes Cancer. 2003 Apr;36(4):393-401 [12619163] Cancer Res. 2003 Mar 15;63(6):1377-81 [12649202] Genes Chromosomes Cancer. 2003 Jul;37(3):326-31 [12759932] Mol Cell Biol. 2003 Jun;23(12):4230-46 [12773566] Blood. 2003 Oct 1;102(7):2321-33 [12791663] Rev Clin Exp Hematol. 2003 Sep;7(3):233-45 [15024967] Trends Mol Med. 2004 Oct;10(10):500-7 [15464450] Cancer Genet Cytogenet. 1983 Jun;9(2):139-44 [6573948] Proc Natl Acad Sci U S A. 1988 Apr;85(7):2076-80 [2832845] Cancer Cells. 1990 Jan;2(1):1-8 [2201335] Int J Cancer. 1990 Nov 15;46(5):808-12 [2228309] Science. 1990 Dec 7;250(4986):1426-9 [2255914] EMBO J. 1992 Feb;11(2):705-16 [1311255] Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10464-8 [1438235] N Engl J Med. 1993 Sep 23;329(13):909-14 [8361504] EMBO J. 1993 Sep;12(9):3679-84 [8253089] Cancer Res. 1994 May 1;54(9):2327-30 [8162575] Med Pediatr Oncol. 1994;23(2):86-98 [8202047] Pediatr Hematol Oncol. 1994 Sep-Oct;11(5):499-507 [7826846] Cancer Res. 1995 Oct 1;55(19):4287-92 [7671237] Blood. 1995 Nov 1;86(9):3542-52 [7579462] Leukemia. 1995 Dec;9(12):2023-6 [8609712] Int Rev Cytol. 1995;162B:405-48 [8557493] Int Rev Cytol. 1995;162A:389-454 [8575884] J Natl Cancer Inst. 1996 Apr 3;88(7):407-18 [8618232] Cancer Res. 1996 Mar 15;56(6):1418-25 [8640834] Blood. 1996 Feb 15;87(4):1211-24 [8608207] Blood. 1996 Mar 1;87(5):1912-22 [8634439] Blood. 1996 Jun 1;87(11):4607-17 [8639829] Blood. 1996 Apr 1;87(7):2649-58 [8639880] Mol Cell Biol. 1997 Jul;17(7):4070-9 [9199342] Genes Chromosomes Cancer. 1997 Oct;20(2):185-95 [9331569] Cancer Res. 1997 Nov 1;57(21):4699-702 [9354424] Cancer Res. 1998 Jan 1;58(1):55-9 [9426057] Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2390-5 [9482895] Hum Mol Genet. 1998 May;7(5):767-76 [9536079] J Clin Oncol. 1998 May;16(5):1897-8 [9586907] Blood. 1998 Jun 15;91(12):4451-6 [9616138] Biochim Biophys Acta. 1998 Oct 1;1400(1-3):139-54 [9748545] Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13176-81 [9789061] Blood. 1998 Nov 15;92(10):3793-803 [9808573] Br J Haematol. 1998 Nov;103(2):539-42 [9827932] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antiinflammatory and Immunosuppressive Activity of Sialostatin L, a Salivary Cystatin from the Tick Ixodes scapularis AN - 19323055; 7061881 AB - Here we report the ability of the tick Ixodes scapularis, the main vector of Lyme disease in the United States, to actively and specifically affect the host proteolytic activity in the sites of infestation through the release of a cystatin constituent of its saliva. The cystatin presence in the saliva was verified both biochemically and immunologically. We named the protein sialostatin L because of its inhibitory action against cathepsin L. We also show that the proteases it targets, although limited in number, have a prominent role in the proteolytic cascades that take place in the extracellular and intracellular environment. As a result, sialostatin L displays an antiinflammatory role and inhibits proliferation of cytotoxic T lymphocytes. Beyond unraveling another component accounting for the properties of tick saliva, contributing to feeding success and pathogen transmission, we describe a novel tool for studying the role of papain-like proteases in diverse biologic phenomena and a protein with numerous potential pharmaceutical applications. JF - Journal of Biological Chemistry AU - Kotsyfakis, Michalis AU - Sa-Nunes, Anderson AU - Francischetti, Ivo MB AU - Mather, Thomas N AU - Andersen, John F AU - Ribeiro, Jose MC AD - Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Rockville, Maryland 20852 and the Center for Vector-Borne Disease, University of Rhode Island, Kingston, Rhode Island 02881 Y1 - 2006/09/08/ PY - 2006 DA - 2006 Sep 08 SP - 26298 EP - 26307 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 36 SN - 0021-9258, 0021-9258 KW - Ticks KW - Microbiology Abstracts B: Bacteriology; Entomology Abstracts; Immunology Abstracts KW - Proteolysis KW - Feeding KW - Ixodidae KW - Vectors KW - Ixodes scapularis KW - Pathogens KW - Immunosuppressive agents KW - Disease transmission KW - Cystatin KW - Infestation KW - Cytotoxicity KW - Cathepsin L KW - Lymphocytes T KW - Borrelia KW - Pharmaceuticals KW - Proteinase KW - Saliva KW - Lyme disease KW - J 02410:Animal Diseases KW - F 06945:Insect Immunity KW - Z 05320:Physiology, Anatomy, and Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19323055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Antiinflammatory+and+Immunosuppressive+Activity+of+Sialostatin+L%2C+a+Salivary+Cystatin+from+the+Tick+Ixodes+scapularis&rft.au=Kotsyfakis%2C+Michalis%3BSa-Nunes%2C+Anderson%3BFrancischetti%2C+Ivo+MB%3BMather%2C+Thomas+N%3BAndersen%2C+John+F%3BRibeiro%2C+Jose+MC&rft.aulast=Kotsyfakis&rft.aufirst=Michalis&rft.date=2006-09-08&rft.volume=281&rft.issue=36&rft.spage=26298&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Feeding; Vectors; Pathogens; Immunosuppressive agents; Disease transmission; Cystatin; Cytotoxicity; Infestation; Cathepsin L; Lymphocytes T; Pharmaceuticals; Proteinase; Saliva; Lyme disease; Ixodidae; Borrelia; Ixodes scapularis ER - TY - CPAPER T1 - Function and Regulation of TRPC1 T2 - 2006 Annual Conference on Cell and Molecular Biology of TRP Channels AN - 40398104; 4437298 DE: JF - 2006 Annual Conference on Cell and Molecular Biology of TRP Channels AU - Ambudkar, Indu Y1 - 2006/09/07/ PY - 2006 DA - 2006 Sep 07 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40398104?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Conference+on+Cell+and+Molecular+Biology+of+TRP+Channels&rft.atitle=Function+and+Regulation+of+TRPC1&rft.au=Ambudkar%2C+Indu&rft.aulast=Ambudkar&rft.aufirst=Indu&rft.date=2006-09-07&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Conference+on+Cell+and+Molecular+Biology+of+TRP+Channels&rft.issn=&rft_id=info:doi/ L2 - http://www.biochemistry.org/meetings/programme.cfm?Meeting_No=SA051 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The signaling helix: a common functional theme in diverse signaling proteins. AN - 68925990; 16953892 AB - The mechanism by which the signals are transmitted between receptor and effector domains in multi-domain signaling proteins is poorly understood. Using sensitive sequence analysis methods we identify a conserved helical segment of around 40 residues in a wide range of signaling proteins, including numerous sensor histidine kinases such as Sln1p, and receptor guanylyl cyclases such as the atrial natriuretic peptide receptor and nitric oxide receptors. We term this helical segment the signaling (S)-helix and present evidence that it forms a novel parallel coiled-coil element, distinct from previously known helical segments in signaling proteins, such as the Dimerization-Histidine phosphotransfer module of histidine kinases, the intra-cellular domains of the chemotaxis receptors, inter-GAF domain helical linkers and the alpha-helical HAMP module. Analysis of domain architectures allowed us to reconstruct the domain-neighborhood graph for the S-helix, which showed that the S-helix almost always occurs between two signaling domains. Several striking patterns in the domain neighborhood of the S-helix also became evident from the graph. It most often separates diverse N-terminal sensory domains from various C-terminal catalytic signaling domains such as histidine kinases, cNMP cyclase, PP2C phosphatases, NtrC-like AAA+ ATPases and diguanylate cyclases. It might also occur between two sensory domains such as PAS domains and occasionally between a DNA-binding HTH domain and a sensory domain. The sequence conservation pattern of the S-helix revealed the presence of a unique constellation of polar residues in the dimer-interface positions within the central heptad of the coiled-coil formed by the S-helix. Combining these observations with previously reported mutagenesis studies on different S-helix-containing proteins we suggest that it functions as a switch that prevents constitutive activation of linked downstream signaling domains. However, upon occurrence of specific conformational changes due to binding of ligand or other sensory inputs in a linked upstream domain it transmits the signal to the downstream domain. Thus, the S-helix represents one of the most prevalent functional themes involved in the flow of signals between modules in diverse prokaryote-type multi-domain signaling proteins. This article was reviewed by Frank Eisenhaber, Arcady Mushegian and Sandor Pongor. JF - Biology direct AU - Anantharaman, Vivek AU - Balaji, S AU - Aravind, L AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. ananthar@mail.nih.gov Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 SP - 25 VL - 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68925990?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biology+direct&rft.atitle=The+signaling+helix%3A+a+common+functional+theme+in+diverse+signaling+proteins.&rft.au=Anantharaman%2C+Vivek%3BBalaji%2C+S%3BAravind%2C+L&rft.aulast=Anantharaman&rft.aufirst=Vivek&rft.date=2006-09-05&rft.volume=1&rft.issue=&rft.spage=25&rft.isbn=&rft.btitle=&rft.title=Biology+direct&rft.issn=1745-6150&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-06-14 N1 - Date created - 2006-10-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Biol Inorg Chem. 2001 Apr;6(4):418-29 [11372200] Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11615-20 [11562502] Trends Biochem Sci. 2001 Oct;26(10):579-82 [11590000] Trends Biochem Sci. 2001 Oct;26(10):582-4 [11590001] Nucleic Acids Res. 2002 Jan 1;30(1):276-80 [11752314] J Mol Biol. 1975 Oct 25;98(2):293-304 [1195389] Mol Microbiol. 2002 Apr;44(1):107-18 [11967072] Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):2738-43 [9501159] Electrophoresis. 1997 Dec;18(15):2714-23 [9504803] Hum Mol Genet. 1998 Jul;7(7):1179-84 [9618177] Trends Cell Biol. 1998 Jul;8(7):260-2 [9714596] Mol Cell. 1998 Oct;2(4):485-93 [9809070] J Bacteriol. 1998 Dec;180(24):6635-41 [9852008] Bioinformatics. 1998;14(9):755-63 [9918945] Mol Microbiol. 2002 Jan;43(2):459-73 [11985722] Genome Res. 2002 Aug;12(8):1190-200 [12176927] Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13260-5 [12271124] J Bacteriol. 2003 Jan;185(1):285-94 [12486065] Nucleic Acids Res. 2003 Jan 1;31(1):383-7 [12520028] Biochem Soc Trans. 2003 Feb;31(Pt 1):1-10 [12546643] BMC Genomics. 2003;4(1):5 [12590654] Trends Biochem Sci. 2003 Mar;28(3):121-4 [12633990] Nucleic Acids Res. 2003 Jul 1;31(13):3381-5 [12824332] J Bacteriol. 2003 Aug;185(16):4872-82 [12897007] BMC Genomics. 2003 Aug 12;4(1):34 [12914674] Curr Opin Microbiol. 2003 Oct;6(5):490-7 [14572542] Cell Signal. 2003 Dec;15(12):1081-9 [14575863] Bioessays. 2004 May;26(5):567-81 [15112237] Appl Bioinformatics. 2002;1(3):111-9 [15130839] Genome Res. 2004 Jun;14(6):1188-90 [15173120] Trends Microbiol. 2004 Oct;12(10):439-41 [15381191] J Mol Biol. 2004 Oct 8;343(1):1-28 [15381417] Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):3082-7 [15708973] Front Biosci. 2005;10:1205-20 [15769619] FEMS Microbiol Rev. 2005 Apr;29(2):231-62 [15808743] Bioinformatics. 2005 Jun 15;21(12):2805-11 [15814558] Adv Protein Chem. 2005;70:37-78 [15837513] EMBO J. 2005 Dec 21;24(24):4247-59 [16319927] Science. 1991 May 24;252(5009):1162-4 [2031185] Comput Appl Biosci. 1994 Dec;10(6):685-6 [7704669] Biochemistry. 1995 Apr 11;34(14):4696-701 [7718574] Microbiol Rev. 1993 Jun;57(2):320-46 [8336670] Neuron. 1993 Jul;11(1):41-52 [8338667] EMBO J. 1996 Dec 16;15(24):6798-809 [9003755] Trends Biochem Sci. 1997 Jan;22(1):12-3 [9020585] Protein Eng. 1997 Jan;10(1):1-6 [9051728] J Mol Med (Berl). 1997 Mar;75(3):160-3 [9106071] J Biol Chem. 1997 May 16;272(20):13365-71 [9148959] Nucleic Acids Res. 1997 Sep 1;25(17):3389-402 [9254694] Structure. 1997 Aug 15;5(8):1017-32 [9309218] Trends Biochem Sci. 1997 Dec;22(12):458-9 [9433123] Mol Cell Biochem. 2003 Nov;253(1-2):167-77 [14619967] Cell. 1992 Dec 24;71(7):1223-37 [1473154] Nucleic Acids Res. 2004;32(5):1792-7 [15034147] J Struct Biol. 2004 Apr-May;146(1-2):11-31 [15037234] Int J Neural Syst. 1997 Oct-Dec;8(5-6):581-99 [10065837] J Mol Biol. 1999 Apr 16;287(5):1023-40 [10222208] Microbiol Mol Biol Rev. 1999 Jun;63(2):479-506 [10357859] FEMS Microbiol Lett. 1999 Jul 1;176(1):111-6 [10418137] Nat Struct Biol. 1999 Aug;6(8):729-34 [10426948] Nature. 1999 Aug 19;400(6746):787-92 [10466731] Mol Microbiol. 1999 Sep;33(6):1093-102 [10510225] Genome Res. 2000 Feb;10(2):204-19 [10673278] Adv Protein Chem. 2000;54:185-244 [10829229] EMBO J. 2000 Jun 1;19(11):2424-34 [10835341] Proteins. 2000 Aug 15;40(3):502-11 [10861942] J Mol Microbiol Biotechnol. 1999 Nov;1(2):303-5 [10943560] Annu Rev Biochem. 2000;69:183-215 [10966457] Trends Biochem Sci. 2000 Nov;25(11):535-7 [11084361] J Mol Biol. 2001 Jan 19;305(3):567-80 [11152613] J Mol Biol. 2001 Apr 13;307(5):1271-92 [11292341] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. AN - 68789244; 16874763 AB - The GABAAalpha2 receptor gene (GABRA2) modulates anxiety and stress response. Three recent association studies implicate GABRA2 in alcoholism, however in these papers both common, opposite-configuration haplotypes in the region distal to intron3 predict risk. We have now replicated the GABRA2 association with alcoholism in 331 Plains Indian men and women and 461 Finnish Caucasian men. Using a dimensional measure of anxiety, harm avoidance (HA), we also found that the association with alcoholism is mediated, or moderated, by anxiety. Nine SNPs were genotyped revealing two haplotype blocks. Within the previously implicated block 2 region, we identified the two common, opposite-configuration risk haplotypes, A and B. Their frequencies differed markedly in Finns and Plains Indians. In both populations, most block 2 SNPs were significantly associated with alcoholism. The associations were due to increased frequencies of both homozygotes in alcoholics, indicating the possibility of alcoholic subtypes with opposite genotypes. Congruently, there was no significant haplotype association. Using HA as an indicator variable for anxiety, we found haplotype linkage to alcoholism with high and low dimensional anxiety, and to HA itself, in both populations. High HA alcoholics had the highest frequency of the more abundant haplotype (A in Finns, B in Plains Indians); low HA alcoholics had the highest frequency of the less abundant haplotype (B in Finns, A in Plains Indians) (Finns: P = 0.007, OR = 2.1, Plains Indians: P = 0.040, OR = 1.9). Non-alcoholics had intermediate frequencies. Our results suggest that within the distal GABRA2 region is a functional locus or loci that may differ between populations but that alters risk for alcoholism via the mediating action of anxiety. JF - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics AU - Enoch, Mary-Anne AU - Schwartz, Lori AU - Albaugh, Bernard AU - Virkkunen, Matti AU - Goldman, David AD - Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA. maenoch@niaaa.nih.gov Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 SP - 599 EP - 607 VL - 141B IS - 6 SN - 1552-4841, 1552-4841 KW - Index Medicus KW - Indians, North American KW - Humans KW - Adult KW - Middle Aged KW - Male KW - Female KW - Finland -- ethnology KW - Genetic Linkage KW - Haplotypes KW - Anxiety -- genetics KW - Alcoholism -- ethnology KW - Anxiety -- ethnology KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68789244?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+medical+genetics.+Part+B%2C+Neuropsychiatric+genetics+%3A+the+official+publication+of+the+International+Society+of+Psychiatric+Genetics&rft.atitle=Dimensional+anxiety+mediates+linkage+of+GABRA2+haplotypes+with+alcoholism.&rft.au=Enoch%2C+Mary-Anne%3BSchwartz%2C+Lori%3BAlbaugh%2C+Bernard%3BVirkkunen%2C+Matti%3BGoldman%2C+David&rft.aulast=Enoch&rft.aufirst=Mary-Anne&rft.date=2006-09-05&rft.volume=141B&rft.issue=6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=American+journal+of+medical+genetics.+Part+B%2C+Neuropsychiatric+genetics+%3A+the+official+publication+of+the+International+Society+of+Psychiatric+Genetics&rft.issn=15524841&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-18 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A biosynthetic pathway for anandamide AN - 19329827; 7064860 AB - The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released "on demand" by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis. Anandamide can be generated from its membrane precursor, N-arachidonoyl phosphatidylethanolamine (NAPE) through cleavage by a phospholipase D (NAPE-PLD). Here we document a biosynthetic pathway for anandamide in mouse brain and RAW264.7 macrophages that involves the phospholipase C (PLC)-catalyzed cleavage of NAPE to generate a lipid, phosphoanandamide, which is subsequently dephosphorylated by phosphatases, including PTPN22, previously described as a protein tyrosine phosphatase. Bacterial endotoxin (LPS)-induced synthesis of anandamide in macrophages is mediated exclusively by the PLC/phosphatase pathway, which is up-regulated by LPS, whereas NAPE-PLD is down-regulated by LPS and functions as a salvage pathway of anandamide synthesis when the PLC/phosphatase pathway is compromised. Both PTPN22 and endocannabinoids have been implicated in autoimmune diseases, suggesting that the PLC/phosphatase pathway of anandamide synthesis may be a pharmacotherapeutic target. JF - Proceedings of the National Academy of Sciences, USA AU - Liu, Jie AU - Wang, Lei AU - Harvey-White, Judith AU - Osei-Hyiaman, Douglas AU - Razdan, Raj AU - Gong, Qian AU - Chan, Andrew C AU - Zhou, Zhifeng AU - Huang, Bill X AU - Kim, Hee-Yong AU - Kunos, George AD - Laboratories of Physiologic Studies, Neurogenetics, and Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/09/05/ PY - 2006 DA - 2006 Sep 05 SP - 13345 EP - 13350 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 36 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology; CSA Neurosciences Abstracts KW - Endotoxins KW - Macrophages KW - Hypotension KW - Cirrhosis KW - Ethanolamine KW - Anandamide KW - Lipids KW - Phospholipase C KW - Autoimmune diseases KW - Phospholipase D KW - Brain KW - Septic shock KW - Protein-tyrosine-phosphatase KW - Cannabinoids KW - Neurons KW - Liver KW - Lipopolysaccharides KW - phosphatidylethanolamine KW - N3 11094:Central nervous system KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19329827?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=A+biosynthetic+pathway+for+anandamide&rft.au=Liu%2C+Jie%3BWang%2C+Lei%3BHarvey-White%2C+Judith%3BOsei-Hyiaman%2C+Douglas%3BRazdan%2C+Raj%3BGong%2C+Qian%3BChan%2C+Andrew+C%3BZhou%2C+Zhifeng%3BHuang%2C+Bill+X%3BKim%2C+Hee-Yong%3BKunos%2C+George&rft.aulast=Liu&rft.aufirst=Jie&rft.date=2006-09-05&rft.volume=103&rft.issue=36&rft.spage=13345&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Hypotension; Macrophages; Endotoxins; Cirrhosis; Anandamide; Ethanolamine; Phospholipase C; Lipids; Phospholipase D; Autoimmune diseases; Brain; Septic shock; Protein-tyrosine-phosphatase; Cannabinoids; Neurons; Liver; Lipopolysaccharides; phosphatidylethanolamine ER - TY - JOUR T1 - Risk of breast, ovary, and uterine corpus cancers among 85 268 women with AIDS AN - 19388003; 7157202 AB - By linking HIV/AIDS and cancer surveillance data in 12 US regions, breast and reproductive cancer risks with AIDS were compared to those in the general population. Trends in standardized incidence ratios (SIRs) were assessed by CD4 count, AIDS-relative time, and calendar time. Standardized incidence ratios were indirectly adjusted for cancer risk factors using data from AIDS cohort participants and the general population. With AIDS, 313 women developed breast cancer (SIR 0.69, 95% confidence interval (CI) 0.62-0.77), 42 developed ovary cancer (SIR 1.05, 95% CI, 0.75-1.42), and 31 developed uterine corpus cancer (SIR 0.57, 95% CI, 0.39-0.81). Uterine cancer risk was reduced significantly after age 50 (SIR 0.33). Breast cancer risk was reduced significantly both before (SIR 0.71) and after (SIR 0.66) age 50, and was lower for local or regional (SIR 0.54) than distant (SIR 0.89) disease. Breast cancer risk varied little by CD4 count (P sub(trend) = 0.47) or AIDS-relative time (P sub(trend) = 0.14) or after adjustment for established cancer risk factors. However, it increased significantly between 1980 and 2002 (P sub(trend) = 0.003), approaching the risk of the general population. We conclude that the cancer deficit reflected direct or indirect effects of HIV/AIDS and that anti-HIV therapy reduced these effects. JF - British Journal of Cancer AU - Goedert, J J AU - Schairer, C AU - McNeel, T S AU - Hessol, NA AU - Rabkin, C S AU - Engels, E A AD - Viral Epidemiology branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA, goedertj@mail.nih.gov Y1 - 2006/09/04/ PY - 2006 DA - 2006 Sep 04 SP - 642 EP - 648 VL - 95 IS - 5 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Virology & AIDS Abstracts KW - Ovarian cancer KW - Acquired immune deficiency syndrome KW - Cancer KW - CD4 antigen KW - Human immunodeficiency virus KW - Risk factors KW - Breast cancer KW - Females KW - Uterine cancer KW - Ovaries KW - V 22360:AIDS and HIV KW - R2 23070:Economics, organization UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19388003?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Risk+of+breast%2C+ovary%2C+and+uterine+corpus+cancers+among+85+268+women+with+AIDS&rft.au=Goedert%2C+J+J%3BSchairer%2C+C%3BMcNeel%2C+T+S%3BHessol%2C+NA%3BRabkin%2C+C+S%3BEngels%2C+E+A&rft.aulast=Goedert&rft.aufirst=J&rft.date=2006-09-04&rft.volume=95&rft.issue=5&rft.spage=642&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603282 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Ovarian cancer; CD4 antigen; Acquired immune deficiency syndrome; Risk factors; Breast cancer; Ovaries; Uterine cancer; Females; Cancer; Human immunodeficiency virus DO - http://dx.doi.org/10.1038/sj.bjc.6603282 ER - TY - CPAPER T1 - Characterization of the Avirulent Rickettsia rickettsii Iowa Strain. T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40263883; 4375120 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Ellison, Damon W AU - Clark, Tina R AU - Hackstadt, Ted Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - USA, Iowa KW - Strains KW - Rickettsia rickettsii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40263883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=Characterization+of+the+Avirulent+Rickettsia+rickettsii+Iowa+Strain.&rft.au=Ellison%2C+Damon+W%3BClark%2C+Tina+R%3BHackstadt%2C+Ted&rft.aulast=Ellison&rft.aufirst=Damon&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genome Sequences of the K (Q154) and G (Q212) Human Q Fever Endocarditis Isolates T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40263770; 4375161 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Beare, Paul A AU - Porcella, Stephen F AU - Kupko, John AU - Seshardi, Rekha AU - Unsworth, Nathan AU - Samuel, James E AU - Heinzen, Robert A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Genomes KW - Endocarditis KW - Q fever KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40263770?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=Genome+Sequences+of+the+K+%28Q154%29+and+G+%28Q212%29+Human+Q+Fever+Endocarditis+Isolates&rft.au=Beare%2C+Paul+A%3BPorcella%2C+Stephen+F%3BKupko%2C+John%3BSeshardi%2C+Rekha%3BUnsworth%2C+Nathan%3BSamuel%2C+James+E%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Atypical Targeting of Host Membrane Proteins to Cholesterol-Rich Membrane Fractions Following Infection by Coxiella burnetii T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40262897; 4375110 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Howe, Dale AU - Heinzen, Robert A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Membrane proteins KW - Infection KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40262897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=Atypical+Targeting+of+Host+Membrane+Proteins+to+Cholesterol-Rich+Membrane+Fractions+Following+Infection+by+Coxiella+burnetii&rft.au=Howe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Howe&rft.aufirst=Dale&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Environmental Tobacco Smoke Pollution in Outdoor Restaurant Premises T2 - 2006 Annual Congress of European Respiratory Society AN - 40262069; 4371394 JF - 2006 Annual Congress of European Respiratory Society AU - Ruprecht, A AU - De Marco, C. AU - Mazza, R AU - Rossetti, E AU - Paredi, P AU - Invernizzi, G AU - Boffi, R Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Passive smoking KW - Pollution KW - Smoke KW - Tobacco UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40262069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Congress+of+European+Respiratory+Society&rft.atitle=Environmental+Tobacco+Smoke+Pollution+in+Outdoor+Restaurant+Premises&rft.au=Ruprecht%2C+A%3BDe+Marco%2C+C.%3BMazza%2C+R%3BRossetti%2C+E%3BParedi%2C+P%3BInvernizzi%2C+G%3BBoffi%2C+R&rft.aulast=Ruprecht&rft.aufirst=A&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Congress+of+European+Respiratory+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.ersnet.org/learning_resources_player/abstract_print_06/main _frameset.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antigen Discovery and Immune Profiling using a Coxiella burnetii Protein Microarray T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40258734; 4375043 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Beare, Paul A AU - Cockrell, Diane C AU - Barbian, Kent D AU - Sturdevant, Daniel E AU - Porcella, Stephen F AU - Pablo, Jozelyn AU - Sasaki, Rie AU - Samuel, James E AU - Felgner, Philip L AU - Heinzen, Robert A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Protein arrays KW - Antigens KW - Profiling KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40258734?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=Antigen+Discovery+and+Immune+Profiling+using+a+Coxiella+burnetii+Protein+Microarray&rft.au=Beare%2C+Paul+A%3BCockrell%2C+Diane+C%3BBarbian%2C+Kent+D%3BSturdevant%2C+Daniel+E%3BPorcella%2C+Stephen+F%3BPablo%2C+Jozelyn%3BSasaki%2C+Rie%3BSamuel%2C+James+E%3BFelgner%2C+Philip+L%3BHeinzen%2C+Robert+A&rft.aulast=Beare&rft.aufirst=Paul&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Growth of Virulent and Avirulent Coxiella burnetii in Human Monocyte-Derived Macrophages and Monkey Primary Alveolar Macrophages T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40258707; 4375172 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Shannon, Jeffrey G AU - Howe, Dale AU - Bailey, John R AU - Gardner, Don J AU - Heinzen, Robert A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Macrophages KW - Monocytes KW - Growth KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40258707?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=Growth+of+Virulent+and+Avirulent+Coxiella+burnetii+in+Human+Monocyte-Derived+Macrophages+and+Monkey+Primary+Alveolar+Macrophages&rft.au=Shannon%2C+Jeffrey+G%3BHowe%2C+Dale%3BBailey%2C+John+R%3BGardner%2C+Don+J%3BHeinzen%2C+Robert+A&rft.aulast=Shannon&rft.aufirst=Jeffrey&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Indoor Air Quality in Italian Restaurants before and after Year 2005 Smoking Restriction Law Enactment T2 - 2006 Annual Congress of European Respiratory Society AN - 40256791; 4368668 JF - 2006 Annual Congress of European Respiratory Society AU - Ruprecht, A AU - Boffi, R AU - Rossetti, E AU - De Marco, C. AU - Paredi, P AU - Invernizzi, G Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Smoking KW - Indoor air pollution UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40256791?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Congress+of+European+Respiratory+Society&rft.atitle=A+Comparison+of+Indoor+Air+Quality+in+Italian+Restaurants+before+and+after+Year+2005+Smoking+Restriction+Law+Enactment&rft.au=Ruprecht%2C+A%3BBoffi%2C+R%3BRossetti%2C+E%3BDe+Marco%2C+C.%3BParedi%2C+P%3BInvernizzi%2C+G&rft.aulast=Ruprecht&rft.aufirst=A&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Congress+of+European+Respiratory+Society&rft.issn=&rft_id=info:doi/ L2 - http://www.ersnet.org/learning_resources_player/abstract_print_06/main _frameset.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Method for Purifying Coxiella Burnetii that Employs Lysis of Host Cells with Digitonin T2 - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AN - 40254555; 4375025 JF - 20th American Society for Rickettsiology Conference and 5th International Conference on Bartonella as Emerging Pathogens AU - Cockrell, Diane C AU - Beare, Paul A AU - Fisher, Elizabeth R AU - Howe, Dale AU - Heinzen, Robert A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Coxiella burnetii KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.atitle=A+Method+for+Purifying+Coxiella+Burnetii+that+Employs+Lysis+of+Host+Cells+with+Digitonin&rft.au=Cockrell%2C+Diane+C%3BBeare%2C+Paul+A%3BFisher%2C+Elizabeth+R%3BHowe%2C+Dale%3BHeinzen%2C+Robert+A&rft.aulast=Cockrell&rft.aufirst=Diane&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=20th+American+Society+for+Rickettsiology+Conference+and+5th+International+Conference+on+Bartonella+as+Emerging+Pathogens&rft.issn=&rft_id=info:doi/ L2 - http://www.vet.ksu.edu/depts/itc/conted/asr/sced.htm LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Reconstitution of the Immune Repertoire and Immune Tolerance After HSCT T2 - 10th Congress of the European Federation of Neurological Societies (EFNS 2006) AN - 40167058; 4321602 JF - 10th Congress of the European Federation of Neurological Societies (EFNS 2006) AU - Muraro, Paolo A Y1 - 2006/09/02/ PY - 2006 DA - 2006 Sep 02 KW - Immunological tolerance KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40167058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2006%29&rft.atitle=Reconstitution+of+the+Immune+Repertoire+and+Immune+Tolerance+After+HSCT&rft.au=Muraro%2C+Paolo+A&rft.aulast=Muraro&rft.aufirst=Paolo&rft.date=2006-09-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+Congress+of+the+European+Federation+of+Neurological+Societies+%28EFNS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/efns2006/programXP/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Glutamate release inhibition ineffective in levodopa-induced motor complications. AN - 85406548; pmid-16758479 AB - Reported benefits of various glutamatergic receptor antagonists in Parkinson's disease (PD) prompted an evaluation of the antidyskinetic effect of a putative glutamate release inhibitor in 15 moderately advanced patients. In a 3-week, double-blind, proof-of-concept study, riluzole (200 mg/day) failed to alter parkinsonian or levodopa-induced motor complication severity. Opposing effects of a generalized inhibition of glutamate-mediated synaptic transmission may limit the usefulness of this approach to treat PD.(c) 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Bara-Jimenez, William AU - Dimitrova, Tzvetelina D AU - Sherzai, Abdullah AU - Aksu, Murat AU - Chase, Thomas N AD - Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. baraw@ninds.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1380 EP - 1383 VL - 21 IS - 9 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Aged KW - *Antiparkinson Agents: adverse effects KW - Antiparkinson Agents: therapeutic use KW - Dose-Response Relationship, Drug KW - Double-Blind Method KW - Drug Administration Schedule KW - *Dyskinesia, Drug-Induced: drug therapy KW - *Excitatory Amino Acid Antagonists: therapeutic use KW - Female KW - *Glutamic Acid: metabolism KW - Humans KW - *Levodopa: adverse effects KW - Levodopa: therapeutic use KW - Male KW - Middle Aged KW - Neurologic Examination: drug effects KW - *Parkinson Disease: drug therapy KW - Riluzole: adverse effects KW - *Riluzole: therapeutic use KW - Treatment Outcome UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85406548?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Glutamate+release+inhibition+ineffective+in+levodopa-induced+motor+complications.&rft.au=Bara-Jimenez%2C+William%3BDimitrova%2C+Tzvetelina+D%3BSherzai%2C+Abdullah%3BAksu%2C+Murat%3BChase%2C+Thomas+N&rft.aulast=Bara-Jimenez&rft.aufirst=William&rft.date=2006-09-01&rft.volume=21&rft.issue=9&rft.spage=1380&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Vertigo: few new spins on a common problem. AN - 69006043; 17069465 AB - Vertigo is a common balance deregulation symptom among elders. Its etiology may be peripheral vestibular disease or a central vestibular disorder. Symptom onset, severity, and duration are distinguishing characteristics. The majority of peripheral vestibular disorders include benign paroxysmal positional vertigo, vestibular neuronitis, Meniere's disease, and perilymph fistula. Medication regimen review is necessary to identify possible drug-induced etiology. Treatment options include pharmacotherapy, canalith repositioning procedures, surgery, vestibular rehabilitation therapy, and dietary interventions. JF - The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists AU - Zanni, Guido R AU - Wick, Jeannette Y AD - National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 680 EP - 696 VL - 21 IS - 9 SN - 0888-5109, 0888-5109 KW - Index Medicus KW - Ear, Inner -- pathology KW - Meniere Disease -- complications KW - Humans KW - Drug-Related Side Effects and Adverse Reactions KW - Ear, Middle -- pathology KW - Diet KW - Vestibular Neuronitis -- complications KW - Fistula -- complications KW - Vertigo -- diagnosis KW - Vertigo -- therapy KW - Vertigo -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/69006043?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.atitle=Vertigo%3A+few+new+spins+on+a+common+problem.&rft.au=Zanni%2C+Guido+R%3BWick%2C+Jeannette+Y&rft.aulast=Zanni&rft.aufirst=Guido&rft.date=2006-09-01&rft.volume=21&rft.issue=9&rft.spage=680&rft.isbn=&rft.btitle=&rft.title=The+Consultant+pharmacist+%3A+the+journal+of+the+American+Society+of+Consultant+Pharmacists&rft.issn=08885109&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-10-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Selected Proceedings of the NICHD/FDA newborn drug development initiative: Part II. AN - 68988423; 17062307 AB - In February 2003, the National Institute of Child Health and Human Development (NICHD) and the US Food and Drug Administration (FDA) created the Newborn Drug Development Initiative (NDDI), an ongoing program to determine gaps in knowledge in neonatal therapeutics and to explore clinical study designs for use in the newborn population. Working groups were established in 3 therapeutic areas: the central nervous, pulmonary, and cardiovascular systems. Three additional groups discussed pain control, drug prioritization, and ethics in neonatal clinical trials. The purpose of this article was to provide an overview of the 5 articles written by members of the Neurology, Cardiology, Drug Prioritization, and Ethics Groups. Information for the current article, as well as the 5 articles presented in this supplemental section, was gathered from the proceedings of a workshop cosponsored by the NICHD and the FDA. This workshop took place March 29 and 30, 2004, in Baltimore, Maryland. The Neurology Group addressed the treatment of 2 common and interrelated conditions in the newborn population: neonatal seizures and hypoxic-ischemic encephalopathy. The unsubstantiated clinical preference for using phenobarbital to treat neonatal seizures, coupled with the development of several newer antiepileptic drugs with application in children, dictates the need for rigorous clinical trials of these drugs in the neonatal population. A number of pharmacologic agents currently undergoing extensive investigations in experimental animals and adult humans may have application in the newborn population. The Cardiology Group reviewed controversial approaches to the diagnosis and treatment of cardiovascular instability of preterm infants and identified gaps in knowledge. The group discussed issues of study design and developed 2 study proposals: (1) a placebo-controlled trial with a rescue arm for symptomatic infants; and (2) a targeted blood pressure (BP) trial. The Drug Prioritization Group focused on the fact that the uniqueness of the newborn population is due to distinctive and changing physiologic characteristics, conditions, and diseases that are different from those affecting older children, as well as the large differences in developmental patterns between 23 weeks of gestation and term. All of these factors help explain the lack of adequate trials and the sparseness of evidence regarding efficacy and toxicity risks of most drugs used in the newborn population. Unfortunately, the frequency of drug use and polypharmacy is highest in very-low-birth-weight infants. The large number of drugs requiring study and the uniqueness of the indications for those drugs preclude the use of the prioritization process used in older children. The focus of the Drug Prioritization Group was the determination of factors that identify which drugs are most important for study. The Ethics Group was unique in that its members were integrated into the therapeutic groups. This approach allowed for the identification of similarities and dissimilarities in the proposed clinical trial design framework. The summary report included here identifies common themes voiced in the various NDDI reports and deliberations. The 5 articles included in this issue address different issues but share common themes: the need to develop innovative trial designs and biomarkers of efficacy, consideration of ethical concerns, and selection of appropriate drugs for study. JF - Clinical therapeutics AU - Giacoia, George P AU - Mattison, Donald R AD - Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland 20847, USA. giacoiag@exchange.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1337 EP - 1341 VL - 28 IS - 9 SN - 0149-2918, 0149-2918 KW - Index Medicus KW - United States KW - United States Food and Drug Administration KW - Humans KW - Infant, Newborn KW - Drug Approval KW - Drug Utilization Review -- organization & administration UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68988423?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+therapeutics&rft.atitle=Selected+Proceedings+of+the+NICHD%2FFDA+newborn+drug+development+initiative%3A+Part+II.&rft.au=Giacoia%2C+George+P%3BMattison%2C+Donald+R&rft.aulast=Giacoia&rft.aufirst=George&rft.date=2006-09-01&rft.volume=28&rft.issue=9&rft.spage=1337&rft.isbn=&rft.btitle=&rft.title=Clinical+therapeutics&rft.issn=01492918&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-11 N1 - Date created - 2006-10-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The debate: a case for randomized controls in invasive aspergillosis. AN - 68968074; 17050456 AB - Randomized trials in invasive aspergillosis have evolved over the past decade. Definitions of disease now include specifics of the underlying disease and how this affects interpretation of certain tests, including high resolution computed tomography and smears or cultures of sputum and bronchoalveolar lavage. Study hypotheses have changed from underpowered superiority trials to adequately powered noninferiority trials. Consensus building between Europe and North America has allowed trials to be conducted with the same protocol in both regions, thereby increasing study enrollment. In aggregate, the following outcomes can be drawn from randomized trials: (i) Liposomal amphotericin B is possibly superior to conventional amphotericin B at 14 days and less toxic. Whether the dose of liposomal amphotericin is 1 or 4 mg/kg daily is not as important as other factors in determining outcome of possible aspergillosis; (ii) amphotericin B colloidal dispersion is less nephrotoxic but has more acute infusion-related reactions than conventional amphotericin B; (iii) starting treatment with voriconazole is superior to starting with conventional amphotericin B. In an era of increasing cost containment, it will be the randomized trials that provide the clinician with the information needed to avoid inappropriate use of expensive drugs and drug combinations. JF - Medical mycology AU - Bennett, John E AD - Clinical Mycology Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. jbennett@niaid.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - S305 EP - S308 VL - 44 Suppl 1 SN - 1369-3786, 1369-3786 KW - Antifungal Agents KW - 0 KW - Index Medicus KW - Humans KW - Clinical Protocols KW - Randomized Controlled Trials as Topic KW - Antifungal Agents -- pharmacology KW - Aspergillosis -- drug therapy KW - Antifungal Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68968074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+mycology&rft.atitle=The+debate%3A+a+case+for+randomized+controls+in+invasive+aspergillosis.&rft.au=Bennett%2C+John+E&rft.aulast=Bennett&rft.aufirst=John&rft.date=2006-09-01&rft.volume=44+Suppl+1&rft.issue=&rft.spage=S305&rft.isbn=&rft.btitle=&rft.title=Medical+mycology&rft.issn=13693786&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-08-30 N1 - Date created - 2006-10-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Monte Carlo dose voxel kernel calculations of beta-emitting and Auger-emitting radionuclides for internal dosimetry: A comparison between EGSnrcMP and EGS4. AN - 68933421; 17022234 AB - Dose-point kernels (DPKs) can be widely applied to therapeutic nuclear medicine to obtain more accurate absorbed dose assessments in internal dosimetry assuming a spherical geometry. Recently, EGSnrc-the latest in the family of EGS Monte Carlo codes--has been tested for isotropic monoenergetic electrons and Y-90 beta spectrum in spherical geometry. The availability of SPECT images allows one to take into account heterogeneities in activity distribution within tumors, and to perform dose calculations using voxel dosimetry based on Monte Carlo simulations in a Cartesian geometry. The purpose of this study is to evaluate the differences of dose distributions scored in Cartesian voxels also known as Dose Voxel Kernels (DVKs) for five beta-emitting (131I, 89Sr, 153Sm, 186Re, and 90Y) and Auger-emitting (111In) radionuclides, when their computation is made using these two Monte Carlo codes from the same family to check if the new physics in EGSnrc simulation system produces DVK very different from those calculated with EGS4. We have calculated the DVKs for point and voxel sources in Cartesian scoring grids of different spatial resolutions. Our results for the point source, scored in the finer spatial resolution, show a poor agreement between EGSnrc and EGS4 (up to about 20%) for voxels closer to the origin, and a better agreement (below 5%) for longer distances for all radionuclides. For the voxel source, where doses were scored in the coarser spatial resolution, dose deposition in the central voxel is in good agreement for all the radionuclides; while surrounding voxels exhibit a slightly worse agreement. JF - Medical physics AU - Strigari, Lidia AU - Menghi, Enrico AU - D'Andrea, Marco AU - Benassi, Marcello AD - Laboratory of Medical Physics and Expert Systems, National Cancer Institute Regina Elena, Rome, 00144 Italy. strigari@ifo.it Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 3383 EP - 3389 VL - 33 IS - 9 SN - 0094-2405, 0094-2405 KW - Radioisotopes KW - 0 KW - Index Medicus KW - Beta Particles -- therapeutic use KW - Relative Biological Effectiveness KW - Computer Simulation KW - Software Validation KW - Radiotherapy Dosage KW - Humans KW - Body Burden KW - Models, Statistical KW - Monte Carlo Method KW - Software KW - Radiotherapy Planning, Computer-Assisted -- methods KW - Algorithms KW - Radioisotopes -- therapeutic use KW - Radioisotopes -- analysis KW - Radiometry -- methods KW - Models, Biological UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68933421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Medical+physics&rft.atitle=Monte+Carlo+dose+voxel+kernel+calculations+of+beta-emitting+and+Auger-emitting+radionuclides+for+internal+dosimetry%3A+A+comparison+between+EGSnrcMP+and+EGS4.&rft.au=Strigari%2C+Lidia%3BMenghi%2C+Enrico%3BD%27Andrea%2C+Marco%3BBenassi%2C+Marcello&rft.aulast=Strigari&rft.aufirst=Lidia&rft.date=2006-09-01&rft.volume=33&rft.issue=9&rft.spage=3383&rft.isbn=&rft.btitle=&rft.title=Medical+physics&rft.issn=00942405&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-10-06 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Co-administration of dextromethorphan with methamphetamine attenuates methamphetamine-induced rewarding and behavioral sensitization. AN - 68908844; 16865411 AB - Methamphetamine (MA) is well known as a potent CNS stimulant, which produces strong rewarding and behavioral sensitization after repeated administration. In the present study, we investigated whether co-administration of dextromethorphan (DM) with MA could suppress these effects induced by acute and chronic MA treatment. The conditioned place preference (CPP) test was used to examine the rewarding/drug seeking effects and locomotor and stereotypic activities were measured to investigate behavioral sensitization induced by chronic MA. Our results revealed that co-administration of DM (20 mg/kg, ip) with MA (2 mg/kg, ip) almost completely abolished the MA-induced CPP and behavioral sensitization. Furthermore, both of the acute and chronic MA could result in an increase of dopamine (DA) turnover rate in the NAc and mPFC. The acute effects of MA on DA turnover rate could be attenuated by the co-administration of DM in both regions. The chronic effect of MA on DA turnover rate in the mPFC was also attenuated by the co-administration of DM. These results suggest that the effect of DM on blocking MA-induced rewarding and behavioral sensitization may be related to its effect on inhibiting the activity of DA neurons projected to mPFC and/or NAc. JF - Journal of biomedical science AU - Yang, Pao-Pao AU - Huang, Eagle Yi-Kung AU - Yeh, Geng-Chang AU - Tao, Pao-Luh AD - Department of Pharmacology, National Defense Medical Center, P.O. Box 90048-504, Nei-Hu 114, Taipei, Taiwan, R.O.C. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 695 EP - 702 VL - 13 IS - 5 SN - 1021-7770, 1021-7770 KW - Central Nervous System Stimulants KW - 0 KW - Excitatory Amino Acid Antagonists KW - Methamphetamine KW - 44RAL3456C KW - Dextromethorphan KW - 7355X3ROTS KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Amphetamine-Related Disorders -- metabolism KW - Reward KW - Prefrontal Cortex -- metabolism KW - Nucleus Accumbens -- metabolism KW - Dopamine -- metabolism KW - Male KW - Behavior, Animal -- drug effects KW - Central Nervous System Stimulants -- pharmacology KW - Dextromethorphan -- pharmacology KW - Methamphetamine -- pharmacology KW - Central Nervous System Stimulants -- antagonists & inhibitors KW - Methamphetamine -- antagonists & inhibitors KW - Excitatory Amino Acid Antagonists -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68908844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomedical+science&rft.atitle=Co-administration+of+dextromethorphan+with+methamphetamine+attenuates+methamphetamine-induced+rewarding+and+behavioral+sensitization.&rft.au=Yang%2C+Pao-Pao%3BHuang%2C+Eagle+Yi-Kung%3BYeh%2C+Geng-Chang%3BTao%2C+Pao-Luh&rft.aulast=Yang&rft.aufirst=Pao-Pao&rft.date=2006-09-01&rft.volume=13&rft.issue=5&rft.spage=695&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomedical+science&rft.issn=10217770&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-24 N1 - Date created - 2006-09-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Utility of plasma free metanephrines in diagnosis of factitious pheochromocytoma. AN - 68897378; 17002933 AB - To report a case of epinephrine-induced factitious pheochromocytoma in a young woman with a past medical history of Conn's syndrome. We present a case report with clinical and laboratory details, review related reports in the literature, and demonstrate the usefulness of plasma free metanephrine levels in facilitating the diagnosis of factitious pheochromocytoma. A 34-year-old woman was admitted to our hospital for confirmation and localization of an occult pheochromocytoma. After thorough investigation, we discovered that the patient was surreptitiously injecting epinephrine in order to induce symptoms and signs consistent with a pheochromocytoma. Analysis of the patient's biochemical profile during and between her catecholaminergic crises revealed plasma epinephrine and free metanephrine levels that would be highly unusual for a patient with a pheochromocytoma. This case illustrates the utility of implementing the ratio of plasma epinephrine to free metanephrine levels in distinguishing factitious from organic pheochromocytoma. JF - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists AU - Chidakel, Aaron R AU - Pacak, Karel AU - Eisenhofer, Graeme AU - Lawrence, Jennifer E AU - Ayala, Alejandro R AD - Division of Intramural Research, National Institute of Diabetes and Digestive and Kidney Diseases, W. G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. PY - 2006 SP - 568 EP - 571 VL - 12 IS - 5 KW - Normetanephrine KW - 0J45DE6B88 KW - Metanephrine KW - 5001-33-2 KW - Norepinephrine KW - X4W3ENH1CV KW - Epinephrine KW - YKH834O4BH KW - Index Medicus KW - Diagnosis, Differential KW - Norepinephrine -- blood KW - Humans KW - Adult KW - Epinephrine -- urine KW - Epinephrine -- administration & dosage KW - Female KW - Normetanephrine -- blood KW - Factitious Disorders -- chemically induced KW - Metanephrine -- urine KW - Factitious Disorders -- blood KW - Pheochromocytoma -- diagnosis KW - Pheochromocytoma -- blood KW - Metanephrine -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68897378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Endocrine+practice+%3A+official+journal+of+the+American+College+of+Endocrinology+and+the+American+Association+of+Clinical+Endocrinologists&rft.atitle=Utility+of+plasma+free+metanephrines+in+diagnosis+of+factitious+pheochromocytoma.&rft.au=Chidakel%2C+Aaron+R%3BPacak%2C+Karel%3BEisenhofer%2C+Graeme%3BLawrence%2C+Jennifer+E%3BAyala%2C+Alejandro+R&rft.aulast=Chidakel&rft.aufirst=Aaron&rft.date=2006-09-01&rft.volume=12&rft.issue=5&rft.spage=568&rft.isbn=&rft.btitle=&rft.title=Endocrine+practice+%3A+official+journal+of+the+American+College+of+Endocrinology+and+the+American+Association+of+Clinical+Endocrinologists&rft.issn=1934-2403&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A simple and reliable approach to docking protein-protein complexes from very sparse NOE-derived intermolecular distance restraints. AN - 68895193; 16967193 AB - A simple and reliable approach for docking protein-protein complexes from very sparse NOE-derived intermolecular distance restraints (as few as three from a single point) in combination with a novel representation for an attractive potential between mapped interaction surfaces is described. Unambiguous assignments of very sparse intermolecular NOEs are obtained using a reverse labeling strategy in which one the components is fully deuterated with the exception of selective protonation of the delta-methyl groups of isoleucine, while the other component is uniformly (13)C-labeled. This labeling strategy can be readily extended to selective protonation of Ala, Leu, Val or Met. The attractive potential is described by a 'reduced' radius of gyration potential applied specifically to a subset of interfacial residues (those with an accessible surface area > or = 50% in the free proteins) that have been delineated by chemical shift perturbation. Docking is achieved by rigid body minimization on the basis of a target function comprising the sparse NOE distance restraints, a van der Waals repulsion potential and the 'reduced' radius of gyration potential. The method is demonstrated for two protein-protein complexes (EIN-HPr and IIA(Glc)-HPr) from the bacterial phosphotransferase system. In both cases, starting from 100 different random orientations of the X-ray structures of the free proteins, 100% convergence is achieved to a single cluster (with near identical atomic positions) with an overall backbone accuracy of approximately 2 A. The approach described is not limited to NMR, since interfaces can also be mapped by alanine scanning mutagenesis, and sparse intermolecular distance restraints can be derived from double cycle mutagenesis, cross-linking combined with mass spectrometry, or fluorescence energy transfer. JF - Journal of biomolecular NMR AU - Tang, Chun AU - Clore, G Marius AD - Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 37 EP - 44 VL - 36 IS - 1 SN - 0925-2738, 0925-2738 KW - Bacterial Proteins KW - 0 KW - Buffers KW - Carbon Isotopes KW - Phosphates KW - Protons KW - Solvents KW - Isoleucine KW - 04Y7590D77 KW - Deuterium KW - AR09D82C7G KW - Phosphoenolpyruvate Sugar Phosphotransferase System KW - EC 2.7.1.- KW - phosphocarrier protein HPr KW - Phosphotransferases (Nitrogenous Group Acceptor) KW - EC 2.7.3.- KW - phosphoenolpyruvate-protein phosphotransferase KW - EC 2.7.3.9 KW - sodium phosphate KW - SE337SVY37 KW - Index Medicus KW - Deuterium -- metabolism KW - Solvents -- chemistry KW - Models, Molecular KW - Phosphates -- chemistry KW - Hydrogen-Ion Concentration KW - Crystallography, X-Ray KW - Protein Structure, Tertiary KW - Protein Binding KW - Molecular Weight KW - Isoleucine -- chemistry KW - Bacterial Proteins -- chemistry KW - Phosphoenolpyruvate Sugar Phosphotransferase System -- chemistry KW - Phosphoenolpyruvate Sugar Phosphotransferase System -- metabolism KW - Nuclear Magnetic Resonance, Biomolecular KW - Bacterial Proteins -- metabolism KW - Bacterial Proteins -- isolation & purification KW - Phosphotransferases (Nitrogenous Group Acceptor) -- chemistry KW - Phosphotransferases (Nitrogenous Group Acceptor) -- isolation & purification KW - Phosphoenolpyruvate Sugar Phosphotransferase System -- isolation & purification KW - Phosphotransferases (Nitrogenous Group Acceptor) -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68895193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+biomolecular+NMR&rft.atitle=A+simple+and+reliable+approach+to+docking+protein-protein+complexes+from+very+sparse+NOE-derived+intermolecular+distance+restraints.&rft.au=Tang%2C+Chun%3BClore%2C+G+Marius&rft.aulast=Tang&rft.aufirst=Chun&rft.date=2006-09-01&rft.volume=36&rft.issue=1&rft.spage=37&rft.isbn=&rft.btitle=&rft.title=Journal+of+biomolecular+NMR&rft.issn=09252738&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-09-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Neurine, an acetylcholine autolysis product, elevates secreted amyloid-beta protein precursor and amyloid-beta peptide levels, and lowers neuronal cell viability in culture: a role in Alzheimer's disease? AN - 68875993; 16988475 AB - Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid-beta peptide (Abeta) that is derived from amyloid-beta protein precursor (AbetaPP) by the action of beta- and gamma-secretases. The trigger(s) initiating the biochemical cascades that underpin these hallmarks have yet to be fully elucidated. The typical forebrain cholinergic cell demise associated with AD brain results in a loss of presynaptic cholinergic markers and acetylcholine (ACh). Neurine (vinyl-trimethyl-ammonium hydroxide) is a breakdown product of ACh, consequent to autolysis and is an organic poison found in cadavre brain. The time- and concentration-dependent actions of neurine were assessed in human neuroblastoma (NB, SK-N-SH) cells in culture by quantifying cell viability by lactate dehydrogenase (LDH) and MTS assay, and AbetaPP and Abeta levels by Western blot and ELISA. NB cells displayed evidence of toxicity to neurine at > or = 3 mg/ml, as demonstrated by elevated LDH levels in the culture media and a reduced cell viability shown by the MTS assay. Using subtoxic concentrations of neurine, elevations in AbetaPP and Abeta1-40 peptide levels were detected in conditioned media samples. JF - Journal of Alzheimer's disease : JAD AU - Tweedie, David AU - Brossi, Arnold AU - Chen, DeMoa AU - Ge, Yuan-Wen AU - Bailey, Jason AU - Yu, Qian-Sheng AU - Kamal, Mohammad A AU - Sambamurti, Kumar AU - Lahiri, Debomoy K AU - Greig, Nigel H AD - Section on Drug Design and Delivery, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 9 EP - 16 VL - 10 IS - 1 SN - 1387-2877, 1387-2877 KW - Amyloid beta-Peptides KW - 0 KW - Amyloid beta-Protein Precursor KW - Cell Adhesion Molecules, Neuron-Glia KW - neurin-1 KW - L-Lactate Dehydrogenase KW - EC 1.1.1.27 KW - Acetylcholine KW - N9YNS0M02X KW - Index Medicus KW - Neuroblastoma -- pathology KW - Cell Death -- physiology KW - Blotting, Western KW - Tumor Cells, Cultured -- metabolism KW - Humans KW - Cell Culture Techniques KW - Tumor Cells, Cultured -- pathology KW - Cell Proliferation KW - Neuroblastoma -- metabolism KW - Cell Survival -- physiology KW - Cell Adhesion Molecules, Neuron-Glia -- physiology KW - Cell Adhesion Molecules, Neuron-Glia -- analysis KW - Cell Adhesion Molecules, Neuron-Glia -- metabolism KW - Acetylcholine -- metabolism KW - Alzheimer Disease -- physiopathology KW - Amyloid beta-Peptides -- biosynthesis KW - Amyloid beta-Protein Precursor -- biosynthesis KW - Autolysis -- physiopathology KW - Alzheimer Disease -- metabolism KW - Neurons -- pathology KW - Alzheimer Disease -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68875993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.atitle=Neurine%2C+an+acetylcholine+autolysis+product%2C+elevates+secreted+amyloid-beta+protein+precursor+and+amyloid-beta+peptide+levels%2C+and+lowers+neuronal+cell+viability+in+culture%3A+a+role+in+Alzheimer%27s+disease%3F&rft.au=Tweedie%2C+David%3BBrossi%2C+Arnold%3BChen%2C+DeMoa%3BGe%2C+Yuan-Wen%3BBailey%2C+Jason%3BYu%2C+Qian-Sheng%3BKamal%2C+Mohammad+A%3BSambamurti%2C+Kumar%3BLahiri%2C+Debomoy+K%3BGreig%2C+Nigel+H&rft.aulast=Tweedie&rft.aufirst=David&rft.date=2006-09-01&rft.volume=10&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Alzheimer%27s+disease+%3A+JAD&rft.issn=13872877&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-20 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dopamine action in the substantia nigra pars reticulata: iontophoretic studies in awake, unrestrained rats. AN - 68874667; 16987223 AB - Dopamine (DA) neurons located in the substantia nigra pars compacta release DA not only via axonal terminals, affecting neurotransmission within the striatum, but also via dendrites, some of which densely protrude into the substantia nigra pars reticulata (SNr). Although the interaction of dendritically released DA with somatodendritic autoreceptors regulates DA cell activity, released DA may also affect SNr neurons. These cells, however, lack postsynaptic DA receptors, making it unclear how locally released DA modulates their activity. Although previous work in brain slices suggests that DA might modulate the activity of GABA inputs, thus affecting SNr neurons indirectly, it remains unclear how increased or decreased DA release might affect these cells exposed to normal afferent inputs. To explore this issue, we examined the effects of iontophoretic DA and amphetamine on SNr neurons in awake, unrestrained rats. DA had no consistent effects on SNr cells but amphetamine, known to induce DA release, dose-dependently inhibited most of them. This effect was blocked by SCH23390, a selective D1 receptor blocker, which itself strongly increased neuronal discharge rate. As GABA input is a major factor regulating the activity of SNr neurons, our data suggest that dendritically released DA, by interacting with D1 receptors on striato-nigral and pallido-nigral afferents, is able to decrease this input, thus releasing SNr neurons from tonic, GABA-mediated inhibition. Surprisingly, a full DA receptor blockade (SCH23390 + eticlopride) did not result in the expected increase in SNr discharge rate, suggesting that other mechanisms are responsible for behavioral abnormalities following acute disruption of DA transmission. JF - The European journal of neuroscience AU - Windels, François AU - Kiyatkin, Eugene A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, DHHS, 333 Cassell Drive, Baltimore, MD 21224, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1385 EP - 1394 VL - 24 IS - 5 SN - 0953-816X, 0953-816X KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Dopamine Uptake Inhibitors KW - Salicylamides KW - Amphetamine KW - CK833KGX7E KW - Tyrosine 3-Monooxygenase KW - EC 1.14.16.2 KW - eticlopride KW - J8M468HBH4 KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Animals KW - Tyrosine 3-Monooxygenase -- metabolism KW - Benzazepines -- pharmacology KW - Drug Interactions KW - Rats, Long-Evans KW - Iontophoresis -- methods KW - Dose-Response Relationship, Drug KW - Dopamine Antagonists -- pharmacology KW - Action Potentials -- drug effects KW - Immunohistochemistry -- methods KW - Rats KW - Salicylamides -- pharmacology KW - Motor Activity -- drug effects KW - Amphetamine -- pharmacology KW - Male KW - Dopamine Uptake Inhibitors -- pharmacology KW - Dopamine -- pharmacology KW - Neurons -- drug effects KW - Wakefulness KW - Substantia Nigra -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68874667?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Dopamine+action+in+the+substantia+nigra+pars+reticulata%3A+iontophoretic+studies+in+awake%2C+unrestrained+rats.&rft.au=Windels%2C+Fran%C3%A7ois%3BKiyatkin%2C+Eugene+A&rft.aulast=Windels&rft.aufirst=Fran%C3%A7ois&rft.date=2006-09-01&rft.volume=24&rft.issue=5&rft.spage=1385&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-14 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Predictors for hematopoietic growth factors use in HIV/HCV-coinfected patients treated with peginterferon alfa 2b and ribavirin. AN - 68872358; 16987047 AB - HIV/hepatitis C virus (HCV)-coinfected individuals have accelerated liver disease, increased drug toxicities, and modest responses to peginterferon and ribavirin. Hematologic toxicities necessitating dose reduction or discontinuation are limiting factors to HCV treatment in the coinfected patient. This study aimed to identify predictors for the need of filgrastim and darbepoetin to manage hematologic toxicities so as to maintain patients on full doses of study drugs for the duration of study. The primary study was a single-center, open-label, prospective study to evaluate the safety, efficacy, and viral kinetics of 48-week peginterferon alfa 2b and ribavirin in HIV/HCV-coinfected patients. Complete blood count was monitored at baseline, days 3, 7, 10, 14, and then weekly for the first month, fortnightly until week 8, then monthly from week 12 to 48. Filgrastim was initiated when absolute neutrophil count (ANC) fell below 750 cells/mm(3) and darbepoetin was used when hemoglobin dropped to less than 10 g/dL. All patients experienced decrease in ANC and hemoglobin. Twenty of 30 (66.6%) of patients required hematopoeitic growth factors, 15 (50%) received filgrastim, and 12 (40%) received darbepoetin. Seven (23.3%) required both. Baseline ANC of less than 2250 cells per millimeter and negative rate of change of hemoglobin on day 3 of therapy were excellent predictors for filgrastim and darbepoetin use, respectively. Supplemental growth factors were associated with substantial increase in overall cost for HCV treatment. Larger clinical trials will be needed to address the cost effectiveness of supplemental growth factor use in the HIV/HCV-coinfected patients. JF - AIDS patient care and STDs AU - Pau, Alice K AU - McLaughlin, Mary M AU - Hu, Zonghui AU - Agyemang, Amma F AU - Polis, Michael A AU - Kottilil, Shyam AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. apau@niaid.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 612 EP - 619 VL - 20 IS - 9 SN - 1087-2914, 1087-2914 KW - Antiviral Agents KW - 0 KW - Hematinics KW - Interferon-alpha KW - Recombinant Proteins KW - Erythropoietin KW - 11096-26-7 KW - Granulocyte Colony-Stimulating Factor KW - 143011-72-7 KW - Darbepoetin alfa KW - 15UQ94PT4P KW - Polyethylene Glycols KW - 30IQX730WE KW - interferon alfa-2b KW - 43K1W2T1M6 KW - Ribavirin KW - 49717AWG6K KW - peginterferon alfa-2b KW - G8RGG88B68 KW - Filgrastim KW - PVI5M0M1GW KW - Index Medicus KW - AIDS/HIV KW - Antiviral Agents -- therapeutic use KW - Antiviral Agents -- administration & dosage KW - Drug Administration Schedule KW - Humans KW - Hematinics -- therapeutic use KW - Hematinics -- economics KW - Adult KW - Middle Aged KW - Antiviral Agents -- adverse effects KW - Male KW - Female KW - Erythropoietin -- analogs & derivatives KW - Ribavirin -- therapeutic use KW - Erythropoietin -- economics KW - Interferon-alpha -- therapeutic use KW - Granulocyte Colony-Stimulating Factor -- therapeutic use KW - Hepatitis C -- complications KW - Erythropoietin -- therapeutic use KW - Ribavirin -- adverse effects KW - Hepatitis C -- drug therapy KW - Interferon-alpha -- adverse effects KW - HIV Infections -- complications KW - Ribavirin -- administration & dosage KW - Granulocyte Colony-Stimulating Factor -- economics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68872358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+patient+care+and+STDs&rft.atitle=Predictors+for+hematopoietic+growth+factors+use+in+HIV%2FHCV-coinfected+patients+treated+with+peginterferon+alfa+2b+and+ribavirin.&rft.au=Pau%2C+Alice+K%3BMcLaughlin%2C+Mary+M%3BHu%2C+Zonghui%3BAgyemang%2C+Amma+F%3BPolis%2C+Michael+A%3BKottilil%2C+Shyam&rft.aulast=Pau&rft.aufirst=Alice&rft.date=2006-09-01&rft.volume=20&rft.issue=9&rft.spage=612&rft.isbn=&rft.btitle=&rft.title=AIDS+patient+care+and+STDs&rft.issn=10872914&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-09-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cigarette smoking, N-acetyltransferase genes and the risk of advanced colorectal adenoma. AN - 68867533; 16981843 AB - Cigarette use is associated with greater risk for colorectal adenoma, a colorectal cancer precursor. N-acetyltransferases, NAT1 and NAT2, are important enzymes involved in the metabolism of aromatic amine carcinogens present in cigarette smoke. Our interest is in the polymorphisms within the NAT1 and NAT2 genes that influence the tobacco-colorectal tumor relationship by impacting on the metabolic activation and detoxification of tobacco smoke-derived carcinogens. In the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening trial, we compared NAT1 and NAT2 gene variant distributions for 772 cases with left-sided advanced adenoma and 777 gender and age-matched controls. Individual NAT1 and NAT2 diplotypes were assigned and NAT2 acetylator phenotypes were derived. Risks for advanced colorectal adenoma were significantly increased among recent smokers (current smokers or those who quit less than 10 years ago) (odds ratio [OR] = 2.3, 95% confidence interval [CI]: 1.7-3.1) and among those who smoked more than 20 cigarettes per day (OR = 1.7, 95% CI: 1.3-2.2), compared with nonsmokers. Risk decreased with increasing NAT2 phenotypic activity (0: slow, 1: intermediate, and 2: rapid) (OR trend: 0.8; 95% CI: 0.7-1.0, p-trend = 0.04) overall. When stratified by smoking status, significant phenotype-associated trends were observed among recent smokers (OR trend = 0.4, 95% CI: 0.3-0.7, p trend <0.001) (p-interaction = 0.02), but not among past or nonsmokers. Diplotypes most strongly associated with lower risks in smokers were NAT2*4/*5B (OR = 0.3, 95% CI: 0.1-0.8, p = 0.01) and NAT2*4/*4 (OR = 0.2, 95% CI: 0.04-0.7, p = 0.02), categorized as intermediate and rapid acetylators, respectively. One NAT1 diplotype, NAT1*4/*10 (OR = 0.5, 95% CI: 0.3-0.9, p = 0.03), was also associated with a decreased risk in smokers. Our study indicated that NAT2 gene variants associated with a slow acetylator phenotype were more susceptible to the effects of tobacco smoking with respect to adenoma risk, providing leads for disease prevention. JF - Pharmacogenomics AU - Moslehi, Roxana AU - Chatterjee, Nilanjan AU - Church, Timothy R AU - Chen, Jinbo AU - Yeager, Meredith AU - Weissfeld, Joel AU - Hein, David W AU - Hayes, Richard B AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd., EPS 8047, Rockville, MD 20852 USA. moslehir@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 819 EP - 829 VL - 7 IS - 6 SN - 1462-2416, 1462-2416 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - United States KW - Polymorphism, Single Nucleotide KW - Humans KW - Aged KW - Pharmacogenetics KW - Genotype KW - Phenotype KW - Mass Screening KW - Risk Factors KW - Case-Control Studies KW - Middle Aged KW - Female KW - Male KW - Adenoma -- enzymology KW - Smoking -- adverse effects KW - Colorectal Neoplasms -- etiology KW - Adenoma -- etiology KW - Colorectal Neoplasms -- genetics KW - Colorectal Neoplasms -- enzymology KW - Adenoma -- genetics KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68867533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenomics&rft.atitle=Cigarette+smoking%2C+N-acetyltransferase+genes+and+the+risk+of+advanced+colorectal+adenoma.&rft.au=Moslehi%2C+Roxana%3BChatterjee%2C+Nilanjan%3BChurch%2C+Timothy+R%3BChen%2C+Jinbo%3BYeager%2C+Meredith%3BWeissfeld%2C+Joel%3BHein%2C+David+W%3BHayes%2C+Richard+B&rft.aulast=Moslehi&rft.aufirst=Roxana&rft.date=2006-09-01&rft.volume=7&rft.issue=6&rft.spage=819&rft.isbn=&rft.btitle=&rft.title=Pharmacogenomics&rft.issn=14622416&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-09-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies. AN - 68866906; 16985027 AB - In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer. Concern lingers regarding this widely used artificial sweetener. We investigated prospectively whether aspartame consumption is associated with the risk of hematopoietic cancers or gliomas (malignant brain cancer). We examined 285,079 men and 188,905 women ages 50 to 71 years in the NIH-AARP Diet and Health Study cohort. Daily aspartame intake was derived from responses to a baseline self-administered food frequency questionnaire that queried consumption of four aspartame-containing beverages (soda, fruit drinks, sweetened iced tea, and aspartame added to hot coffee and tea) during the past year. Histologically confirmed incident cancers were identified from eight state cancer registries. Multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards regression that adjusted for age, sex, ethnicity, body mass index, and history of diabetes. During over 5 years of follow-up (1995-2000), 1,888 hematopoietic cancers and 315 malignant gliomas were ascertained. Higher levels of aspartame intake were not associated with the risk of overall hematopoietic cancer (RR for >/=600 mg/d, 0.98; 95% CI, 0.76-1.27), glioma (RR for >/=400 mg/d, 0.73; 95% CI, 0.46-1.15; P for inverse linear trend = 0.05), or their subtypes in men and women. Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Lim, Unhee AU - Subar, Amy F AU - Mouw, Traci AU - Hartge, Patricia AU - Morton, Lindsay M AU - Stolzenberg-Solomon, Rachael AU - Campbell, David AU - Hollenbeck, Albert R AU - Schatzkin, Arthur AD - Division of Cancer Control and Population Sciences, National Cancer Institute, 6130 Executive Boulevard, EPN 4005, Rockville, MD 20852-7344, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1654 EP - 1659 VL - 15 IS - 9 SN - 1055-9965, 1055-9965 KW - Aspartame KW - Z0H242BBR1 KW - Index Medicus KW - Prospective Studies KW - Humans KW - Incidence KW - Aged KW - Middle Aged KW - Male KW - Female KW - Hematologic Neoplasms -- chemically induced KW - Brain Neoplasms -- epidemiology KW - Beverages -- adverse effects KW - Aspartame -- adverse effects KW - Hematologic Neoplasms -- epidemiology KW - Brain Neoplasms -- chemically induced UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68866906?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Consumption+of+aspartame-containing+beverages+and+incidence+of+hematopoietic+and+brain+malignancies.&rft.au=Lim%2C+Unhee%3BSubar%2C+Amy+F%3BMouw%2C+Traci%3BHartge%2C+Patricia%3BMorton%2C+Lindsay+M%3BStolzenberg-Solomon%2C+Rachael%3BCampbell%2C+David%3BHollenbeck%2C+Albert+R%3BSchatzkin%2C+Arthur&rft.aulast=Lim&rft.aufirst=Unhee&rft.date=2006-09-01&rft.volume=15&rft.issue=9&rft.spage=1654&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-09-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1527-8; author reply 1528-9 [17627023] Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1295-6 [18483354] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Future of toxicology--a shift in the paradigm: focus on human disease. AN - 68857647; 16978015 JF - Chemical research in toxicology AU - Schwartz, David A AD - National Institute of Environmental Health Sciences and National Toxicology Program, P.O. Box 12233, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1121 EP - 1124 VL - 19 IS - 9 SN - 0893-228X, 0893-228X KW - Index Medicus KW - Genome, Human KW - Humans KW - Environmental Exposure KW - Disease KW - Toxicology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68857647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+research+in+toxicology&rft.atitle=Future+of+toxicology--a+shift+in+the+paradigm%3A+focus+on+human+disease.&rft.au=Schwartz%2C+David+A&rft.aulast=Schwartz&rft.aufirst=David&rft.date=2006-09-01&rft.volume=19&rft.issue=9&rft.spage=1121&rft.isbn=&rft.btitle=&rft.title=Chemical+research+in+toxicology&rft.issn=0893228X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-13 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Eosinophilic crystalline pneumonia as a major cause of death in 129S4/SvJae mice. AN - 68856641; 16966445 AB - Eosinophilic crystalline pneumonia is an idiopathic disease that occurs in many strains and stocks of mice, more commonly in strains on a C57BL/6 background. The disease occurs sporadically in most strains of mice and varies from mild and subclinical to severe and fulminating, sometimes resulting in respiratory distress and death. In this study, 94 aged male and female 129S4/SvJae mice were evaluated for eosinophilic crystalline pneumonia lesions. There was an 87% incidence, with females overrepresented. Histologically, there were multifocal to coalescing inflammatory infiltrates composed of numerous large eosinophilic macrophages and multinucleate cells admixed with eosinophils, neutrophils, lymphocytes, and plasma cells within alveolar and bronchiolar spaces, associated with refractile, brightly eosinophilic, angular crystals. Alveolar macrophages and multinucleate cells contained fine needlelike to rectangular intracytoplasmic crystalline material. Similar crystals were often free within alveoli and conducting airways, often associated with mucous metaplasia of bronchiolar epithelium. This disease may occur spontaneously or in concert with other pulmonary lesions, such as pulmonary adenomas, lymphoproliferative disease, allergic pulmonary disease, and parasitic or fungal infections. The characteristic crystals morphologically resemble Charcot-Leyden crystals, which represent eosinophil breakdown products in humans with eosinophil-related disease. However, crystals in eosinophilic crystalline pneumonia are composed predominantly of Ym1 protein, a chitinase-like protein associated with neutrophil granule products and secreted by activated macrophages. The function of Ym1 protein is not fully understood but is believed to be involved in host immune defense, eosinophil recruitment, and cell-cell and cell-matrix interactions consistent with tissue repair. The mechanism of induction of eosinophilic crystalline pneumonia with Ym1 crystal formation is unknown. JF - Veterinary pathology AU - Hoenerhoff, M J AU - Starost, M F AU - Ward, J M AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, 41 Library Drive, Building 41, Room C619, Bethesda, MD 20892, USA. hoenerhm@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 682 EP - 688 VL - 43 IS - 5 SN - 0300-9858, 0300-9858 KW - Lectins KW - 0 KW - Chi3l3 protein, mouse KW - EC 3.2.1.52 KW - beta-N-Acetylhexosaminidases KW - Index Medicus KW - Crystallization KW - Mice, Inbred Strains KW - Animals KW - Sex Characteristics KW - Aging KW - Mice KW - Lung -- pathology KW - Male KW - Female KW - Pulmonary Eosinophilia -- veterinary KW - beta-N-Acetylhexosaminidases -- metabolism KW - Pulmonary Eosinophilia -- mortality KW - Rodent Diseases -- pathology KW - Rodent Diseases -- mortality KW - Pulmonary Eosinophilia -- pathology KW - Lectins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68856641?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Veterinary+pathology&rft.atitle=Eosinophilic+crystalline+pneumonia+as+a+major+cause+of+death+in+129S4%2FSvJae+mice.&rft.au=Hoenerhoff%2C+M+J%3BStarost%2C+M+F%3BWard%2C+J+M&rft.aulast=Hoenerhoff&rft.aufirst=M&rft.date=2006-09-01&rft.volume=43&rft.issue=5&rft.spage=682&rft.isbn=&rft.btitle=&rft.title=Veterinary+pathology&rft.issn=03009858&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-07 N1 - Date created - 2006-09-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antisocial personality disorder with childhood- vs. adolescence-onset conduct disorder: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68851074; 16971818 AB - This study, based on a nationally representative, epidemiologic sample (N = 43,093, response rate 81%), compared sociodemographic and family history correlates, antisocial personality disorder (ASPD) symptom patterns, and Axis I and Axis II comorbidity, among adults with DSM-IV ASPD who reported onset of conduct disorder (CD) in childhood ( or =age 10). Prevalence of each ASPD diagnostic criterion and comorbid lifetime disorder was estimated. Logistic regression was used to examine associations of childhood-onset CD with ASPD symptom patterns and comorbid disorders. Among the 1422 respondents with ASPD, 447 reported childhood-onset CD. Childhood-onset respondents were more likely than adolescence-onset respondents to endorse CD criteria involving aggression against persons, animals, and property before age 15, and to endorse more childhood criteria and lifetime violent behaviors. Childhood-onset respondents displayed significantly elevated odds of lifetime social phobia, generalized anxiety disorder, drug dependence, and paranoid, schizoid, and avoidant personality disorders, but significantly decreased odds for lifetime tobacco dependence. Childhood-onset CD appears to identify a more polysymptomatic and violent form of ASPD, associated with greater lifetime comorbidity for selected Axis I and Axis II disorders, in nonclinical populations. JF - The Journal of nervous and mental disease AU - Goldstein, Risë B AU - Grant, Bridget F AU - Ruan, W June AU - Smith, Sharon M AU - Saha, Tulshi D AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 667 EP - 675 VL - 194 IS - 9 SN - 0022-3018, 0022-3018 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Violence -- statistics & numerical data KW - Age of Onset KW - Mental Disorders -- epidemiology KW - Humans KW - Mental Disorders -- psychology KW - Child KW - Comorbidity KW - Cross-Sectional Studies KW - Mental Disorders -- diagnosis KW - Logistic Models KW - Adult KW - Health Surveys KW - Psychiatric Status Rating Scales -- statistics & numerical data KW - Adolescent KW - United States -- epidemiology KW - Violence -- psychology KW - Male KW - Diagnostic and Statistical Manual of Mental Disorders KW - Female KW - Alcohol-Related Disorders -- epidemiology KW - Antisocial Personality Disorder -- epidemiology KW - Conduct Disorder -- diagnosis KW - Conduct Disorder -- epidemiology KW - Conduct Disorder -- psychology KW - Antisocial Personality Disorder -- diagnosis KW - Antisocial Personality Disorder -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68851074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+nervous+and+mental+disease&rft.atitle=Antisocial+personality+disorder+with+childhood-+vs.+adolescence-onset+conduct+disorder%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Goldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F%3BRuan%2C+W+June%3BSmith%2C+Sharon+M%3BSaha%2C+Tulshi+D&rft.aulast=Goldstein&rft.aufirst=Ris%C3%AB&rft.date=2006-09-01&rft.volume=194&rft.issue=9&rft.spage=667&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+nervous+and+mental+disease&rft.issn=00223018&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-13 N1 - Date created - 2006-09-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: J Nerv Ment Dis. 2008 Mar;196(3):263 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Non-human primate models of inheritance vulnerability to alcohol use disorders. AN - 68846116; 16961765 AB - Many animal species have been used to model certain aspects of alcohol use and addiction. However, there are complex behavioral and social features of alcohol use disorders that are not easily modeled in animal species. This review considers both the limitations and advantages of using a non-human primate to model alcohol use disorders and discusses how non-human primates can be particularly useful for studying how genetic variants interact with social factors, temperament and alcohol response as motivating factors for alcohol consumption and abstinence. Genetic variants in rhesus macaques (Macaca mulatta) that are functionally equivalent to those increasing addiction vulnerability in humans influence temperament, stress reactivity and alcohol response in addition to voluntary alcohol consumption. Non-human primate models may also have translational value for understanding of how variants within addiction and abuse vulnerability genes influence alcohol-induced neuroadaptation, neuropathology and treatment response. JF - Addiction biology AU - Barr, Christina S AU - Goldman, David AD - NIH/NIAAA, Laboratory of Clinical and Translational Studies, Poolesville, MD 20837, USA. cbarr@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 374 EP - 385 VL - 11 IS - 3-4 SN - 1355-6215, 1355-6215 KW - Central Nervous System Depressants KW - 0 KW - Serotonin KW - 333DO1RDJY KW - Ethanol KW - 3K9958V90M KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Index Medicus KW - Animals KW - Age Factors KW - Ethanol -- administration & dosage KW - Temperament KW - Macaca mulatta KW - Genetic Predisposition to Disease KW - Serotonin -- genetics KW - Central Nervous System Depressants -- administration & dosage KW - Monoamine Oxidase -- genetics KW - Alcoholism -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68846116?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction+biology&rft.atitle=Non-human+primate+models+of+inheritance+vulnerability+to+alcohol+use+disorders.&rft.au=Barr%2C+Christina+S%3BGoldman%2C+David&rft.aulast=Barr&rft.aufirst=Christina&rft.date=2006-09-01&rft.volume=11&rft.issue=3-4&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Addiction+biology&rft.issn=13556215&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Using a site visit to a contaminated location as a focus for environmental health education for academic and public health nurses. AN - 68836772; 16961561 AB - We describe a conference initiative that is distinguished by the use of a "community case study" to increase the knowledge and skills of nursing faculty and public health nurses in environmental health and to provide networking support to facilitate infusion of environmental health into nursing curricula and public health nursing practice. The Institute of Medicine's (1995) general environmental health competencies for nurses provided the conference framework. Woburn, Massachusetts, a Superfund site, served as the community case study to illustrate a complex environmental health problem. Over an extended period of time, Woburn was contaminated with multiple chemicals that eventually contaminated the drinking water supply; a cluster of childhood leukemia cases was linked subsequently to the Superfund site contaminants. A 6-hr interpreted walking and bus tour of the Superfund site enabled us to visit the premises of responsible parties, the vapor extraction fields, the capped Well H in the wooded wetlands, and to tour the affected neighborhood. This intensive, hands-on approach to learning environmental health content and skills that incorporated multiple learning strategies serves as a model for developing future conferences for public health nurses and nursing faculty. JF - Public health nursing (Boston, Mass.) AU - Backus, Ann S N AU - Hewitt, Jeanne Beauchamp AU - Chalupka, Stephanie M AD - HSPH-NIEHS Center for Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. abackus@hohp.harvard.edu PY - 2006 SP - 410 EP - 432 VL - 23 IS - 5 SN - 0737-1209, 0737-1209 KW - Hazardous Waste KW - 0 KW - Index Medicus KW - Nursing KW - United States KW - Models, Educational KW - Health Services Needs and Demand KW - Nursing Methodology Research KW - Attitude of Health Personnel KW - Humans KW - Nursing Education Research KW - Referral and Consultation KW - Professional Competence KW - Faculty, Nursing KW - Nursing Staff -- psychology KW - Risk Assessment KW - National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division KW - Nursing Assessment KW - Massachusetts KW - Curriculum KW - Program Development KW - Nurse's Role KW - Program Evaluation KW - Nursing Staff -- education KW - Environmental Health -- education KW - Hazardous Waste -- adverse effects KW - Hazardous Waste -- statistics & numerical data KW - Education, Nursing, Continuing -- organization & administration KW - Public Health Nursing -- education UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68836772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Public+health+nursing+%28Boston%2C+Mass.%29&rft.atitle=Using+a+site+visit+to+a+contaminated+location+as+a+focus+for+environmental+health+education+for+academic+and+public+health+nurses.&rft.au=Backus%2C+Ann+S+N%3BHewitt%2C+Jeanne+Beauchamp%3BChalupka%2C+Stephanie+M&rft.aulast=Backus&rft.aufirst=Ann+S&rft.date=2006-09-01&rft.volume=23&rft.issue=5&rft.spage=410&rft.isbn=&rft.btitle=&rft.title=Public+health+nursing+%28Boston%2C+Mass.%29&rft.issn=07371209&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-20 N1 - Date created - 2006-09-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Age of alcohol-dependence onset: associations with severity of dependence and seeking treatment. AN - 68824221; 16950966 AB - We explored whether people who become alcohol dependent at younger ages are more likely to seek alcohol-related help or treatment or experience chronic relapsing dependence. In 2001-2002 the National Institute on Alcohol Abuse and Alcoholism completed a face-to-face interview survey with a multistage probability sample of 43,093 adults aged > or = 18, with a response rate of 81%. We focused on 4778 persons diagnosable as alcohol dependent ever in their lives using Diagnositic and Statistical Manual of Mental Disorders, Fourth Edition criteria. Logistic regression examined whether respondents ever sought alcohol-related help or treatment, controlling for respondent demographics, number of dependence symptoms experienced, smoking and illicit drug use, childhood antisocial personality and depression, family history of alcoholism, and age of drinking onset. Of persons ever alcohol dependent, 15% were diagnosable before age 18, 47% before age 21, and two thirds before age 25. Twenty-eight percent reported > or = 2 dependence episodes, 45% experienced an episode exceeding 1 year, and 34% reported 6 or 7 dependence criteria. Relative to those first alcohol dependent at > or = 30 years, 21% of those ever dependent, the odds of ever seeking help were lower among those first dependent before ages 18, 20, and 25. Yet, persons first dependent at < or = 25 years had significantly greater odds of experiencing multiple dependence episodes, episodes exceeding 1 year, and more dependence symptoms. Analyses indicated that the previously reported increased odds that persons who start to drink at an early age develop features of chronic relapsing dependence may have resulted from early drinkers being more likely to develop alcohol dependence at younger ages. This, in turn, increased their odds of experiencing multiple and longer episodes of alcohol dependence with more symptoms. Adolescents need to be screened and counseled about alcohol, and treatment services should be reinforced by programs and policies to delay age of first alcohol dependence. JF - Pediatrics AU - Hingson, Ralph W AU - Heeren, Timothy AU - Winter, Michael R AD - Youth Alcohol Prevention Center, Boston University School of Public Health, 715 Albany St, Boston, Massachusetts 02118, USA. rhingson@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - e755 EP - e763 VL - 118 IS - 3 KW - Abridged Index Medicus KW - Index Medicus KW - Severity of Illness Index KW - Age of Onset KW - Humans KW - Health Surveys KW - Adult KW - Adolescent KW - Recurrence KW - Male KW - Female KW - Alcoholism -- therapy KW - Alcoholism -- classification KW - Health Behavior KW - Alcoholism -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68824221?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Age+of+alcohol-dependence+onset%3A+associations+with+severity+of+dependence+and+seeking+treatment.&rft.au=Hingson%2C+Ralph+W%3BHeeren%2C+Timothy%3BWinter%2C+Michael+R&rft.aulast=Hingson&rft.aufirst=Ralph&rft.date=2006-09-01&rft.volume=118&rft.issue=3&rft.spage=e755&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - High levels of dopamine D2 receptors in unaffected members of alcoholic families: possible protective factors. AN - 68822694; 16953002 AB - Predisposition to alcoholism is likely an interaction between genetic and environmental factors that confer vulnerability and protection. Alcoholic subjects have low levels of dopamine D(2) receptors in striatum, and increasing D(2) receptor levels in laboratory animals reduces alcohol consumption. To test whether high levels of D(2) receptors may be protective against alcoholism and whether this is mediated by their modulation of activity in orbitofrontal cortex and cingulate gyrus (regions involved in salience attribution, emotional reactivity, and inhibitory control). Research (nonalcoholic subjects with a family history of alcoholism) and comparison (nonalcoholic subjects with a negative family history) sample. Outpatient setting. Fifteen nonalcoholic subjects who had an alcoholic father and at least 2 other first- or second-degree relatives who were alcoholics (family-positive group) and 16 nonalcoholic controls with no family history of alcoholism (family-negative group). Results of positron emission tomography with raclopride C 11 to assess D(2) receptors and with fludeoxyglucose F 18 to assess brain glucose metabolism (marker of brain function). Personality measures were obtained with the Multidimensional Personality Questionnaire. Availability of D(2) receptors was significantly higher in caudate and ventral striatum in family-positive than family-negative subjects. In family-positive but not family-negative subjects, striatal D(2) receptors were associated with metabolism in anterior cingulate (Brodmann area 24/25) and orbitofrontal (Brodmann area 11) and prefrontal (Brodmann area 9/10) cortices, and with personality scores of positive emotionality. The higher-than-normal D(2) receptor availability in nonalcoholic members of alcoholic families supports the hypothesis that high levels of D(2) receptors may protect against alcoholism. The significant associations between D(2) receptors and metabolism in frontal regions involved with emotional reactivity and executive control suggest that high levels of D(2) receptors could protect against alcoholism by regulating circuits involved in inhibiting behavioral responses and in controlling emotions. JF - Archives of general psychiatry AU - Volkow, Nora D AU - Wang, Gene-Jack AU - Begleiter, Henri AU - Porjesz, Bernice AU - Fowler, Joanna S AU - Telang, Frank AU - Wong, Christopher AU - Ma, Yeming AU - Logan, Jean AU - Goldstein, Rita AU - Alexoff, David AU - Thanos, Peter K AD - National Institute on Drug Abuse, 6001 Executive Boulevard, Rockville, MD 20857, USA. nvolkow@nida.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 999 EP - 1008 VL - 63 IS - 9 SN - 0003-990X, 0003-990X KW - Receptors, Dopamine D2 KW - 0 KW - Fluorodeoxyglucose F18 KW - 0Z5B2CJX4D KW - Raclopride KW - 430K3SOZ7G KW - Glucose KW - IY9XDZ35W2 KW - Abridged Index Medicus KW - Index Medicus KW - Caudate Nucleus -- diagnostic imaging KW - Caudate Nucleus -- metabolism KW - Positron-Emission Tomography KW - Humans KW - Gyrus Cinguli -- diagnostic imaging KW - Glucose -- metabolism KW - Frontal Lobe -- diagnostic imaging KW - Personality -- classification KW - Ambulatory Care KW - Emotions -- physiology KW - Gyrus Cinguli -- metabolism KW - Adult KW - Frontal Lobe -- metabolism KW - Genetic Predisposition to Disease KW - Personality Assessment KW - Basal Ganglia -- diagnostic imaging KW - Male KW - Female KW - Basal Ganglia -- metabolism KW - Family KW - Alcoholism -- metabolism KW - Brain -- metabolism KW - Receptors, Dopamine D2 -- genetics KW - Alcoholism -- genetics KW - Brain -- diagnostic imaging KW - Alcoholism -- prevention & control KW - Receptors, Dopamine D2 -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68822694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+general+psychiatry&rft.atitle=High+levels+of+dopamine+D2+receptors+in+unaffected+members+of+alcoholic+families%3A+possible+protective+factors.&rft.au=Volkow%2C+Nora+D%3BWang%2C+Gene-Jack%3BBegleiter%2C+Henri%3BPorjesz%2C+Bernice%3BFowler%2C+Joanna+S%3BTelang%2C+Frank%3BWong%2C+Christopher%3BMa%2C+Yeming%3BLogan%2C+Jean%3BGoldstein%2C+Rita%3BAlexoff%2C+David%3BThanos%2C+Peter+K&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2006-09-01&rft.volume=63&rft.issue=9&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=Archives+of+general+psychiatry&rft.issn=0003990X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-21 N1 - Date created - 2006-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fetal origin of childhood disease: intrauterine growth restriction in term infants and risk for hypertension at 6 years of age. AN - 68822237; 16953023 AB - To examine the association between intrauterine growth restriction (IUGR) status at birth among full-term infants, exposure to substance use during pregnancy, and risk of hypertension at 6 years of age. Prospective evaluation of high-risk children. Four centers of the National Institute of Child Health and Human Development Neonatal Research Network. One thousand three hundred eighty-eight infants (600 cocaine exposed, 781 nonexposed, and 7 indeterminate, matched by gestational age, race, and sex), were enrolled at these sites. Nine hundred fifty children (415 exposed, 535 nonexposed) were followed up for 6 years. Intervention Right arm blood pressure was measured using the Dinamap portable adult/pediatric monitor with appropriate cuff size. Main Outcome Measure Blood pressure levels. Hypertension was defined as either systolic or diastolic blood pressure higher than the 95th percentile for sex, age, and height. Eight hundred ninety-one children had blood pressure data at 6 years of age: 516 were born at full term; 144 (28%) of the 516 children had a diagnosis of IUGR at birth. At 6 years of age, 93 (19%) of 516 children had hypertension. Of 144 children with IUGR, 35 (24%) had hypertension as compared with 58 (16%) of 372 children without IUGR (P<.05). Twenty percent of cocaine-exposed children had hypertension as compared with 16% of nonexposed children (P = .20). Intrauterine growth restriction status at birth was significantly associated with hypertension (relative risk, 1.8 [95% confidence interval, 1.2-2.7]) when multivariable Poisson regression analysis was performed adjusting for site; maternal race, education, and tobacco, marijuana, alcohol, and cocaine use during pregnancy; and child's current body mass index (calculated as weight in kilograms divided by height in meters squared). In term infants, IUGR is linked to risk of hypertension in early childhood, which may be a marker for adult cardiovascular disease. JF - Archives of pediatrics & adolescent medicine AU - Shankaran, Seetha AU - Das, Abhik AU - Bauer, Charles R AU - Bada, Henrietta AU - Lester, Barry AU - Wright, Linda AU - Higgins, Rosemary AU - Poole, Kenneth AD - National Institute of Child Health and Human Development Neonatal Research Network, Bethesda, MD, USA. sshankar@med.wayne.edu Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 977 EP - 981 VL - 160 IS - 9 SN - 1072-4710, 1072-4710 KW - Abridged Index Medicus KW - Index Medicus KW - Risk Factors KW - Humans KW - Adult KW - Child KW - Poisson Distribution KW - Longitudinal Studies KW - Male KW - Female KW - Pregnancy KW - Hypertension -- etiology KW - Cocaine-Related Disorders -- complications KW - Fetal Growth Retardation KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68822237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Archives+of+pediatrics+%26+adolescent+medicine&rft.atitle=Fetal+origin+of+childhood+disease%3A+intrauterine+growth+restriction+in+term+infants+and+risk+for+hypertension+at+6+years+of+age.&rft.au=Shankaran%2C+Seetha%3BDas%2C+Abhik%3BBauer%2C+Charles+R%3BBada%2C+Henrietta%3BLester%2C+Barry%3BWright%2C+Linda%3BHiggins%2C+Rosemary%3BPoole%2C+Kenneth&rft.aulast=Shankaran&rft.aufirst=Seetha&rft.date=2006-09-01&rft.volume=160&rft.issue=9&rft.spage=977&rft.isbn=&rft.btitle=&rft.title=Archives+of+pediatrics+%26+adolescent+medicine&rft.issn=10724710&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-13 N1 - Date created - 2006-09-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Differential alterations in metabolic pattern of the spliceosomal UsnRNAs during pre-malignant lung lesions induced by benzo(a)pyrene: modulation by tea polyphenols. AN - 68819829; 16718374 AB - The differential alterations of the spliceosomal UsnRNAs (U1, U2, U4, U5, and U6) were reported to be associated with cellular proliferation and development. The attempt was made in this study to analyze the metabolic pattern of the spliceosomal UsnRNAs during the development of pre-malignant lung lesions induced in experimental mice model system by benzo(a)pyrene (BP) and also to see how tea polyphenols, epigallocatechin gallate (EGCG) and epicatechin gallate (ECG), modulate the metabolism of these UsnRNAs during the lung carcinogenesis. No significant changes in the level of the UsnRNAs were seen in the inflammatory lung lesions at 9th week due to treatment of BP. However, there was significant increase in the level of U1 ( approximately 2.5 fold) and U5 ( approximately 47%) in the hyperplastic lung lesions at 17th week. But in the mild dysplastic lung lesions at 26th week, the level of UsnRNAs did not change significantly. Whereas, in the dysplastic lung lesions at 36th week there was significant increase in the level of the U2 ( approximately 2 fold), U4 ( approximately 2.5 fold) and U5 ( approximately 2 fold). Due to the EGCG and ECG treatment the lung lesions at 9th week appeared normal and in the 17th, 26th, and 36th week it appeared as hyperplasia. The level of the UsnRNAs was significantly low in the lung lesions at 9th week (only U2 and U4 by EGCG), at 17th week (only U1 by EGCG/ECG), at 26th week (U1 by ECG; U2, U4 and U5 by EGCG/ECG) and at 36th week (U1 by ECG, U2 and U4 by EGCG/ECG). Whereas, there was significant increase in the level of U5 (by EGCG/ECG) and U6 (by EGCG only) in the lung lesions at 36th and 26th week respectively. This indicates that the metabolism of the spliceosomal UsnRNAs differentially altered during the development of pre-malignant lung lesions by BP as well as during the modulation of the lung lesions by the tea polyphenols. JF - Molecular and cellular biochemistry AU - Manna, Sugata AU - Banerjee, Sarmistha AU - Saha, Prosenjit AU - Roy, Anup AU - Das, Sukta AU - Panda, Chinmay Kr AD - Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 149 EP - 157 VL - 289 IS - 1-2 SN - 0300-8177, 0300-8177 KW - Flavonoids KW - 0 KW - Phenols KW - Polyphenols KW - RNA, Small Nuclear KW - Tea KW - Benzo(a)pyrene KW - 3417WMA06D KW - Catechin KW - 8R1V1STN48 KW - epicatechin gallate KW - 92587OVD8Z KW - epigallocatechin gallate KW - BQM438CTEL KW - Index Medicus KW - Animals KW - Lung -- cytology KW - Catechin -- analogs & derivatives KW - Mice KW - Lung -- pathology KW - Catechin -- pharmacology KW - Spliceosomes -- metabolism KW - RNA, Small Nuclear -- metabolism KW - Phenols -- pharmacology KW - Precancerous Conditions -- chemically induced KW - Tea -- chemistry KW - Lung Neoplasms -- chemically induced KW - Flavonoids -- pharmacology KW - Spliceosomes -- drug effects KW - Precancerous Conditions -- pathology KW - Lung Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68819829?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+and+cellular+biochemistry&rft.atitle=Differential+alterations+in+metabolic+pattern+of+the+spliceosomal+UsnRNAs+during+pre-malignant+lung+lesions+induced+by+benzo%28a%29pyrene%3A+modulation+by+tea+polyphenols.&rft.au=Manna%2C+Sugata%3BBanerjee%2C+Sarmistha%3BSaha%2C+Prosenjit%3BRoy%2C+Anup%3BDas%2C+Sukta%3BPanda%2C+Chinmay+Kr&rft.aulast=Manna&rft.aufirst=Sugata&rft.date=2006-09-01&rft.volume=289&rft.issue=1-2&rft.spage=149&rft.isbn=&rft.btitle=&rft.title=Molecular+and+cellular+biochemistry&rft.issn=03008177&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children. AN - 68818313; 16923923 AB - Tenofovir disoproxil fumarate, a nucleotide analog HIV reverse transcriptase inhibitor with demonstrated activity against nucleoside-resistant HIV, is approved for use in adults but not children. Metabolic bone abnormalities have been seen in young animals given high-dose tenofovir and HIV-infected adults that were treated with oral tenofovir disoproxil fumarate. However, tenofovir disoproxil fumarate is being used in children despite a lack of bone safety data. We hypothesized that, given the higher rate of bone turnover that is associated with normal skeletal growth, the potential for TDF-related bone toxicity may be greater in children than in adults. Fifteen highly antiretroviral-experienced HIV-infected children who were 8 to 16 years of age (mean +/- SD: 12 +/- 2) and required a change in therapy received tenofovir disoproxil fumarate 175 to 300 mg/m2 per day (adult dose equivalent) as part of highly active antiretroviral therapy for up to 96 weeks. Bone mineral density of the lumbar spine, femoral neck, and total hip by dual-energy x-ray absorptiometry and blood and urine markers of bone metabolism were measured at 0, 24, 48, 72, and 96 weeks. Median z score (SD score compared with age, gender, and ethnicity-matched control subjects) of the lumbar spine, femoral neck, and total hip were decreased from baseline at 24 weeks and 48 weeks and then stabilized. Lumbar spine bone mineral apparent density (which estimates volumetric bone mineral density independent of bone size) z scores also decreased at 24 weeks. Absolute decreases in bone mineral density were observed in 6 children; the mean age of these children was significantly younger than the bone mineral density stable group (10.2 +/- 1.1 vs 13.2 +/- 1.8 years). The change in lumbar spine bone mineral density correlated with decreases in HIV plasma RNA during treatment. Metabolic markers of bone formation and resorption were variable. Two children in whom tenofovir disoproxil fumarate was discontinued because of bone loss that exceeded protocol allowances demonstrated partial or complete recovery of bone mineral density by 96 weeks. Tenofovir disoproxil fumarate use in children seems to be associated with decreases in bone mineral density that, in some children, stabilize after 24 weeks. Increases in bone markers and calcium excretion suggest that tenofovir disoproxil fumarate may stimulate bone resorption. Bone turnover is higher in children than in older adolescents and adults because of skeletal growth, potentially explaining the greater effect seen in young children. Decreases in bone mineral density correlate with decreases in viral load and young age, suggesting that young responders may be at greater risk for bone toxicity. JF - Pediatrics AU - Gafni, Rachel I AU - Hazra, Rohan AU - Reynolds, James C AU - Maldarelli, Frank AU - Tullio, Antonella N AU - DeCarlo, Ellen AU - Worrell, Carol J AU - Flaherty, John F AU - Yale, Kitty AU - Kearney, Brian P AU - Zeichner, Steven L AD - HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - e711 EP - e718 VL - 118 IS - 3 KW - Anti-Retroviral Agents KW - 0 KW - Organophosphonates KW - Tenofovir KW - 99YXE507IL KW - Adenine KW - JAC85A2161 KW - Abridged Index Medicus KW - Index Medicus KW - Age Factors KW - Humans KW - Salvage Therapy KW - Bone Development -- drug effects KW - Child KW - Adolescent KW - Male KW - Female KW - Bone Density -- drug effects KW - Adenine -- therapeutic use KW - Organophosphonates -- therapeutic use KW - Organophosphonates -- adverse effects KW - HIV Infections -- drug therapy KW - Adenine -- analogs & derivatives KW - Adenine -- adverse effects KW - Anti-Retroviral Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68818313?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Tenofovir+disoproxil+fumarate+and+an+optimized+background+regimen+of+antiretroviral+agents+as+salvage+therapy%3A+impact+on+bone+mineral+density+in+HIV-infected+children.&rft.au=Gafni%2C+Rachel+I%3BHazra%2C+Rohan%3BReynolds%2C+James+C%3BMaldarelli%2C+Frank%3BTullio%2C+Antonella+N%3BDeCarlo%2C+Ellen%3BWorrell%2C+Carol+J%3BFlaherty%2C+John+F%3BYale%2C+Kitty%3BKearney%2C+Brian+P%3BZeichner%2C+Steven+L&rft.aulast=Gafni&rft.aufirst=Rachel&rft.date=2006-09-01&rft.volume=118&rft.issue=3&rft.spage=e711&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=1098-4275&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-09-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pretreatment with neem (Azadirachta indica) leaf preparation in Swiss mice diminishes leukopenia and enhances the antitumor activity of cyclophosphamide. AN - 68809361; 16807877 AB - Cancer chemotherapy is associated with several life threatening complications, including bone marrow suppression and leucopenia. To overcome this problem, colony stimulating factor (CSF), granulocyte colony stimulating factor (GCSF) and granulocyte macrophage colony stimulating factor (GMCSF), can be used, however, these therapeutics are expensive and have several disadvantages, including tumor growth promoting activities. This study attempted to use an immunostimulatory neem (Azadirachta indica) leaf preparation (NLP) to prevent the cyclophosphamide (CYP) induced reduction in the WBC count. Pretreatment of mice with NLP reduced the extent of leucopenia and neutropenia in normal and tumor bearing CYP treated mice. NLP pretreatment enhanced in vitro tumor cell cytotoxicity by peripheral blood mononuclear cells (PBMC) from CYP treated mice in either normal or tumor bearing conditions. Similarly, NLP pretreatment of mice enhanced the CYP mediated in vivo tumor growth inhibition and survivability of the host. Based on these observations, it is concluded that NLP would be an effective tool to reduce CYP-induced hematological complications. Copyright (c) 2006 John Wiley & Sons, Ltd. JF - Phytotherapy research : PTR AU - Ghosh, Diptendu AU - Bose, Anamika AU - Haque, Enamul AU - Baral, Rathindranath AD - Department of Immunoregulation and Immunodiagnostics, Chittaranjan National Cancer Institute, Kolkata-700026, India. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 814 EP - 818 VL - 20 IS - 9 SN - 0951-418X, 0951-418X KW - Antineoplastic Agents, Alkylating KW - 0 KW - Plant Extracts KW - Cyclophosphamide KW - 8N3DW7272P KW - Index Medicus KW - Phytotherapy KW - Animals KW - Plant Leaves KW - Carcinoma, Ehrlich Tumor -- drug therapy KW - Mice KW - Leukocytes, Mononuclear -- drug effects KW - Drug Synergism KW - Female KW - Plant Extracts -- pharmacology KW - Azadirachta KW - Plant Extracts -- therapeutic use KW - Antineoplastic Agents, Alkylating -- adverse effects KW - Leukopenia -- etiology KW - Leukopenia -- drug therapy KW - Cyclophosphamide -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68809361?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Phytotherapy+research+%3A+PTR&rft.atitle=Pretreatment+with+neem+%28Azadirachta+indica%29+leaf+preparation+in+Swiss+mice+diminishes+leukopenia+and+enhances+the+antitumor+activity+of+cyclophosphamide.&rft.au=Ghosh%2C+Diptendu%3BBose%2C+Anamika%3BHaque%2C+Enamul%3BBaral%2C+Rathindranath&rft.aulast=Ghosh&rft.aufirst=Diptendu&rft.date=2006-09-01&rft.volume=20&rft.issue=9&rft.spage=814&rft.isbn=&rft.btitle=&rft.title=Phytotherapy+research+%3A+PTR&rft.issn=0951418X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-02 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - AP-1-directed human T cell leukemia virus type 1 viral gene expression during monocytic differentiation. AN - 68805463; 16829632 AB - Human T cell leukemia virus type 1 (HTLV-1) has previously been shown to infect antigen-presenting cells and their precursors in vivo. However, the role these important cell populations play in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis or adult T cell leukemia remains unresolved. To better understand how HTLV-1 infection of these important cell populations may potentially impact disease progression, the regulation of HTLV-1 viral gene expression in established monocytic cell lines was examined. U-937 promonocytic cells transiently transfected with a HTLV-1 long-terminal repeat (LTR) luciferase construct were treated with phorbol 12-myristate 13-acetate (PMA) to induce cellular differentiation. PMA-induced cellular differentiation resulted in activation of basal and Tax-mediated transactivation of the HTLV-1 LTR. In addition, electrophoretic mobility shift analyses demonstrated that PMA-induced cellular differentiation induced DNA-binding activity of cellular transcription factors to Tax-responsive element 1 (TRE-1) repeat II. Supershift analyses revealed that factors belonging to the activator protein 1 (AP-1) family of basic region/leucine zipper proteins (Fra-1, Fra-2, JunB, and JunD) were induced to bind to TRE-1 repeat II during cellular differentiation. Inhibition of AP-1 DNA-binding activity by overexpression of a dominant-negative c-Fos mutant (A-Fos) in transient expression analyses resulted in severely decreased levels of HTLV-1 LTR activation in PMA-induced U-937 cells. These results have suggested that following infection of peripheral blood monocytes, HTLV-1 viral gene expression may become up-regulated by AP-1 during differentiation into macrophages or dendritic cells. JF - Journal of leukocyte biology AU - Grant, Christian AU - Jain, Pooja AU - Nonnemacher, Michael AU - Flaig, Katherine E AU - Irish, Bryan AU - Ahuja, Jaya AU - Alexaki, Aikaterini AU - Alefantis, Timothy AU - Wigdahl, Brian AD - Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 640 EP - 650 VL - 80 IS - 3 SN - 0741-5400, 0741-5400 KW - Gene Products, tax KW - 0 KW - Transcription Factor AP-1 KW - phorbolol myristate acetate KW - 56937-68-9 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Base Sequence KW - Tetradecanoylphorbol Acetate -- analogs & derivatives KW - Humans KW - Molecular Sequence Data KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Up-Regulation -- immunology KW - Gene Products, tax -- immunology KW - Cell Differentiation -- drug effects KW - Protein Binding KW - Genes, fos -- immunology KW - Cell Differentiation -- immunology KW - Human T-lymphotropic virus 1 -- genetics KW - Monocytes -- immunology KW - Monocytes -- drug effects KW - Human T-lymphotropic virus 1 -- isolation & purification KW - Human T-lymphotropic virus 1 -- immunology KW - Monocytes -- virology KW - Gene Expression Regulation, Viral -- genetics KW - Transcription Factor AP-1 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68805463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+leukocyte+biology&rft.atitle=AP-1-directed+human+T+cell+leukemia+virus+type+1+viral+gene+expression+during+monocytic+differentiation.&rft.au=Grant%2C+Christian%3BJain%2C+Pooja%3BNonnemacher%2C+Michael%3BFlaig%2C+Katherine+E%3BIrish%2C+Bryan%3BAhuja%2C+Jaya%3BAlexaki%2C+Aikaterini%3BAlefantis%2C+Timothy%3BWigdahl%2C+Brian&rft.aulast=Grant&rft.aufirst=Christian&rft.date=2006-09-01&rft.volume=80&rft.issue=3&rft.spage=640&rft.isbn=&rft.btitle=&rft.title=Journal+of+leukocyte+biology&rft.issn=07415400&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-07 N1 - Date created - 2006-08-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Evolution and function of leukocyte RNase A ribonucleases of the avian species, Gallus gallus. AN - 68797112; 16803891 AB - In this study, we explore the evolution and function of two closely related RNase A ribonucleases from the chicken, Gallus gallus. Separated by approximately 10 kb on chromosome 6, the coding sequences of RNases A-1 and A-2 are diverging under positive selection pressure (dN > dS) but remain similar to one another (81% amino acid identity) and to the mammalian angiogenins. Immunoreactive RNases A-1 and A-2 (both approximately 16 kDa) were detected in peripheral blood granulocytes and bone marrow. Recombinant proteins are ribonucleolytically active (kcat = 2.6 and 0.056 s(-1), respectively), and surprisingly, both interact with human placental ribonuclease inhibitor. RNase A-2, the more cationic (pI 11.0), is both angiogenic and bactericidal; RNase A-1 (pI 10.2) has neither activity. We demonstrated via point mutation of the catalytic His110 that ablation of ribonuclease activity has no impact on the bactericidal activity of RNase A-2. We determined that the divergent domains II (amino acids 71-76) and III (amino acids 89-104) of RNase A-2 are both important for bactericidal activity. Furthermore, we demonstrated that these cationic domains can function as independent bactericidal peptides without the tertiary structure imposed by the RNase A backbone. These results suggest that ribonucleolytic activity may not be a crucial constraint limiting the ongoing evolution of this gene family and that the ribonuclease backbone may be merely serving as a scaffold to support the evolution of novel, nonribonucleolytic proteins. JF - The Journal of biological chemistry AU - Nitto, Takeaki AU - Dyer, Kimberly D AU - Czapiga, Meggan AU - Rosenberg, Helene F AD - Laboratory of Allergic Diseases and Research Technologies Branch, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 25622 EP - 25634 VL - 281 IS - 35 SN - 0021-9258, 0021-9258 KW - Ribonuclease, Pancreatic KW - EC 3.1.27.5 KW - Index Medicus KW - Phylogeny KW - Mutagenesis, Site-Directed KW - Bone Marrow Cells -- metabolism KW - Animals KW - Chickens KW - Kinetics KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Sequence Homology, Amino Acid KW - Protein Structure, Tertiary KW - Evolution, Molecular KW - Leukocytes -- metabolism KW - Leukocytes -- enzymology KW - Ribonuclease, Pancreatic -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68797112?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+biological+chemistry&rft.atitle=Evolution+and+function+of+leukocyte+RNase+A+ribonucleases+of+the+avian+species%2C+Gallus+gallus.&rft.au=Nitto%2C+Takeaki%3BDyer%2C+Kimberly+D%3BCzapiga%2C+Meggan%3BRosenberg%2C+Helene+F&rft.aulast=Nitto&rft.aufirst=Takeaki&rft.date=2006-09-01&rft.volume=281&rft.issue=35&rft.spage=25622&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+biological+chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-10 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - DQ395276; GENBANK; DQ395275 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Fra-1 a target for cancer prevention or intervention. AN - 68788310; 16784822 AB - The transcription factor activator protein-1 (AP-1) has been implicated as a driver of carcinogenesis since its original characterization. Oncogenic transcription factors like AP-1 are becoming new targets for cancer intervention. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. The Fos related antigen-1 (Fra-1) is activated in multiple cancers and gene ablation can suppress the invasive phenotypes of many tumor cell lines. This review focuses on the regulation of fosl1 expression, stabilization and activation of the Fra-1 polypeptide and on Fra-1-mediated tumorigenesis. JF - Gene AU - Young, Matthew R AU - Colburn, Nancy H AD - Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, MD 21702, USA. youngm@ncifcrf.gov Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 1 EP - 11 VL - 379 SN - 0378-1119, 0378-1119 KW - Proto-Oncogene Proteins c-fos KW - 0 KW - Transcription Factor AP-1 KW - fos-related antigen 1 KW - Index Medicus KW - Gene Expression Regulation, Neoplastic KW - Animals KW - Transcription Factor AP-1 -- metabolism KW - Humans KW - Cell Transformation, Neoplastic -- metabolism KW - Models, Biological KW - Neoplasms -- drug therapy KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Proto-Oncogene Proteins c-fos -- genetics KW - Proto-Oncogene Proteins c-fos -- antagonists & inhibitors KW - Neoplasms -- prevention & control KW - Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788310?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=Fra-1+a+target+for+cancer+prevention+or+intervention.&rft.au=Young%2C+Matthew+R%3BColburn%2C+Nancy+H&rft.aulast=Young&rft.aufirst=Matthew&rft.date=2006-09-01&rft.volume=379&rft.issue=&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A functional polymorphism in the MAOA gene promoter (MAOA-LPR) predicts central dopamine function and body mass index. AN - 68783649; 16770335 AB - Variation in brain monoaminergic activity is heritable and modulates risk of alcoholism and other addictions, as well as food intake and energy expenditure. Monoamine oxidase A deaminates the monoamine neurotransmitters serotonin, dopamine (DA), and noradrenaline. The monoamine oxidase A (MAOA) gene (Xp11.5) contains a length polymorphism in its promoter region (MAOA-LPR) that putatively affects transcriptional efficiency. Our goals were to test (1) whether MAOA-LPR contributes to interindividual variation in monoamine activity, assessed using levels of cerebrospinal fluid (CSF) monoamine metabolites; and (2) whether MAOA-LPR genotype influences alcoholism and/or body mass index (BMI). Male, unrelated criminal alcoholics (N=278) and controls (N=227) were collected from a homogeneous Finnish source population. CSF concentration of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) were available from 208 participants. Single allele, hemizygous genotypes were grouped according to inferred effect of the MAOA alleles on transcriptional activity. MAOA-LPR genotypes had a significant effect on CSF HVA concentration (P=0.01) but explained only 3% of the total variance. There was a detectable but nonsignificant genotype effect on 5-HIAA and no effects on MHPG. Specifically, the genotype conferring high MAOA activity was associated with lower HVA levels in both alcoholics and controls, a finding that persisted after accounting for the potential confounds of alcoholism, BMI, height, and smoking. MAOA-LPR genotype predicted BMI (P<0.005), with the high-activity genotype being associated with lower BMI. MAOA-LPR genotypes were not associated with alcoholism or related psychiatric phenotypes in this data set. Our results suggest that MAOA-LPR allelic variation modulates DA turnover in the CNS, but does so in a manner contrary to our prior expectation that alleles conferring high activity would predict higher HVA levels in CSF. Our results are consistent with an emerging literature that suggests greater complexity in how variation in MAOA expression alters monoaminergic function. Finally, our work suggests that MAOA may be involved in the regulation of BMI. Independent samples are necessary to confirm this preliminary finding. JF - Molecular psychiatry AU - Ducci, F AU - Newman, T K AU - Funt, S AU - Brown, G L AU - Virkkunen, M AU - Goldman, D AD - Laboratory of Neurogenetics, NIAAA, NIH, Rockville, MD 20852, USA. ducci@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 858 EP - 866 VL - 11 IS - 9 SN - 1359-4184, 1359-4184 KW - Methoxyhydroxyphenylglycol KW - 534-82-7 KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Monoamine Oxidase KW - EC 1.4.3.4 KW - Dopamine KW - VTD58H1Z2X KW - Homovanillic Acid KW - X77S6GMS36 KW - Index Medicus KW - Genotype KW - Homovanillic Acid -- cerebrospinal fluid KW - Methoxyhydroxyphenylglycol -- cerebrospinal fluid KW - Finland KW - Humans KW - Hydroxyindoleacetic Acid -- cerebrospinal fluid KW - Male KW - Monoamine Oxidase -- cerebrospinal fluid KW - Minisatellite Repeats KW - Promoter Regions, Genetic KW - Crime KW - Polymorphism, Genetic KW - Alcoholism -- cerebrospinal fluid KW - Dopamine -- physiology KW - Body Mass Index KW - Alcoholism -- genetics KW - Monoamine Oxidase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68783649?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+psychiatry&rft.atitle=A+functional+polymorphism+in+the+MAOA+gene+promoter+%28MAOA-LPR%29+predicts+central+dopamine+function+and+body+mass+index.&rft.au=Ducci%2C+F%3BNewman%2C+T+K%3BFunt%2C+S%3BBrown%2C+G+L%3BVirkkunen%2C+M%3BGoldman%2C+D&rft.aulast=Ducci&rft.aufirst=F&rft.date=2006-09-01&rft.volume=11&rft.issue=9&rft.spage=858&rft.isbn=&rft.btitle=&rft.title=Molecular+psychiatry&rft.issn=13594184&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-27 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. AN - 68764140; 16624829 AB - Glutathione S-transferases (GSTs) are phase II enzymes that are involved in the detoxification of a wide range of carcinogens. The novel GSTA1*A and GSTA1*B genetic polymorphism results in differential expression, with lower transcriptional activation of GSTA1*B (variant) than that of GSTA1*A (common) allele. Considering that cruciferous vegetables induce GSTs, which metabolize tobacco smoke carcinogens, we hypothesized that the variant GSTA1*B genotype may predispose women to breast cancer, particularly among low cruciferous vegetable consumers and among smokers. Thus, we evaluated potential relationships between GSTA1 polymorphisms and breast cancer risk, in relation to vegetable consumption and smoking status in the Long Island Breast Cancer Study Project (1996-1997), a population-based case-control study. Genotyping (1036 cases and 1089 controls) was performed, and putative breast cancer risk factors and usual dietary intakes were assessed. Having GSTA1*A/*B or *B/*B genotypes was not associated with increased breast cancer risk, compared to having the common *A/*A genotype. However, among women in the lowest two tertiles of cruciferous vegetable consumption, *B/*B genotypes were associated with increased risk (OR (95% CI)=1.73 (1.10-2.72) for 0-1 servings/week), compared to women with *A/*A genotypes. Among women with *B/*B genotypes, a significant inverse trend between cruciferous vegetable consumption and breast cancer risk was observed (P for trend=0.05), and higher consumption (4+ servings/week) ameliorated the increased risk associated with the genotype. Current smokers with *B/*B genotypes had a 1.89-fold increase in risk (OR (95% CI)=1.89 (1.09-3.25)), compared with never smokers with *A/*A genotypes. These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers. JF - Carcinogenesis AU - Ahn, Jiyoung AU - Gammon, Marilie D AU - Santella, Regina M AU - Gaudet, Mia M AU - Britton, Julie A AU - Teitelbaum, Susan L AU - Terry, Mary Beth AU - Neugut, Alfred I AU - Eng, Sybil M AU - Zhang, Yuesheng AU - Garza, Cutberto AU - Ambrosone, Christine B AD - Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. ahnj@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1876 EP - 1882 VL - 27 IS - 9 SN - 0143-3334, 0143-3334 KW - Isoenzymes KW - 0 KW - Glutathione Transferase KW - EC 2.5.1.18 KW - glutathione S-transferase alpha KW - Index Medicus KW - Risk KW - Vegetables KW - Odds Ratio KW - Alleles KW - Risk Factors KW - Humans KW - Diet KW - Transcriptional Activation KW - Female KW - Genotype KW - Breast Neoplasms -- genetics KW - Breast Neoplasms -- prevention & control KW - Glutathione Transferase -- genetics KW - Isoenzymes -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68764140?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Effects+of+glutathione+S-transferase+A1+%28GSTA1%29+genotype+and+potential+modifiers+on+breast+cancer+risk.&rft.au=Ahn%2C+Jiyoung%3BGammon%2C+Marilie+D%3BSantella%2C+Regina+M%3BGaudet%2C+Mia+M%3BBritton%2C+Julie+A%3BTeitelbaum%2C+Susan+L%3BTerry%2C+Mary+Beth%3BNeugut%2C+Alfred+I%3BEng%2C+Sybil+M%3BZhang%2C+Yuesheng%3BGarza%2C+Cutberto%3BAmbrosone%2C+Christine+B&rft.aulast=Ahn&rft.aufirst=Jiyoung&rft.date=2006-09-01&rft.volume=27&rft.issue=9&rft.spage=1876&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-16 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Application of magnetic resonance imaging in developmental neurotoxicity testing: a pilot study. AN - 68763521; 16860869 AB - In a pilot developmental neurotoxicity study, a protocol was designed to utilize three-dimensional magnetic resonance (MR) images for linear and volumetric measurements of the developing rat brain. MR imaging, because of its non-destructive nature, provides a complement to traditional optical microscopy. Sprague-Dawley dams received 0, 1.25, 4.0 or 7.5mg/kg methylazoxymethanol acetate (MAM) by intraperitoneal injection during gestation days 13-15. At postnatal days (PND) 23 and 60, brains from representative male and female rats from two dams in each dose group were fixed with 10% neutral buffered formalin by transcardial perfusion for in situ MR imaging. A 7T small animal magnet system was used to obtain isotropic images at 100 microm resolution for PND 23 and 150 microm resolution for PND 60. Data from a rapid screening method based on midpoint MR slices of whole brain, cerebrum, cerebellum, and hippocampus showed a dose-related decreased volume of whole brain, cerebrum, and hippocampus in treated rats. Subsequent volumetric estimates using the Cavalieri method confirmed these findings. The brains were subsequently removed and processed for conventional histologic examination of hematoxylin and eosin-stained sections. It is concluded that MR imaging in rat developmental neurotoxicity studies offers the advantages of in situ volumetric measurements of brain structures while preserving the samples for conventional optical microscopy. JF - Neurotoxicology AU - Johnson, Kennita AU - Ryan, Linda AU - Davis, Jeffrey AU - Elmore, Amy AU - Guenther, Brett AU - Marcus, Jill AU - Maronpot, Robert R AD - Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences/NIH/DHHS, 111 Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, United States. johnso58@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 846 EP - 851 VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - Protein Synthesis Inhibitors KW - 0 KW - Methylazoxymethanol Acetate KW - 592-62-1 KW - Index Medicus KW - Animals KW - Methylazoxymethanol Acetate -- toxicity KW - Dose-Response Relationship, Drug KW - Pilot Projects KW - Image Processing, Computer-Assisted -- methods KW - Pregnancy KW - Rats KW - Animals, Newborn KW - Rats, Sprague-Dawley KW - Protein Synthesis Inhibitors -- toxicity KW - Body Weight -- drug effects KW - Female KW - Male KW - Organ Size -- drug effects KW - Neurotoxicity Syndromes -- diagnosis KW - Magnetic Resonance Imaging -- methods KW - Hippocampus -- growth & development KW - Neurotoxicity Syndromes -- etiology KW - Hippocampus -- pathology KW - Hippocampus -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68763521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Application+of+magnetic+resonance+imaging+in+developmental+neurotoxicity+testing%3A+a+pilot+study.&rft.au=Johnson%2C+Kennita%3BRyan%2C+Linda%3BDavis%2C+Jeffrey%3BElmore%2C+Amy%3BGuenther%2C+Brett%3BMarcus%2C+Jill%3BMaronpot%2C+Robert+R&rft.aulast=Johnson&rft.aufirst=Kennita&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=846&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-08-21 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma. AN - 68763347; 16543247 AB - Evidence supporting the contribution of oxidative stress to key pathways in cancer, such as inflammation and DNA damage, continues to mount. We investigated variations within genes mediating oxidative stress to determine whether they alter risk for non-Hodgkin lymphoma (NHL). Thirteen single nucleotide polymorphisms (SNPs) from 10 oxidative stress genes (AKR1A1, AKR1C1, CYBA, GPX, MPO, NOS2A, NOS3, OGG1, PPARG and SOD2) were genotyped in 1172 NHL cases and 982 population-based controls from a USA multicenter case-control study. For NHL and five subtypes (diffuse large B-cell, follicular, marginal zone, small lymphocytic and T-cell), SNP associations were calculated. Odds ratios (OR) and 95% confidence intervals (CI) were adjusted for sex, age (<45, 45-64, 65+ years), race (white, black, other) and study site. Overall, the oxidative stress pathway was associated significantly with the B-cell NHL subtype, diffuse large B-cell lymphoma (DLBCL) (global P-value=0.003). Specifically, for nitric oxide synthase (NOS2A Ser608Leu, rs2297518) Leu/Leu homozygotes, there was a 2-fold risk increase for NHL (OR=2.2, 95% CI=1.1-4.4) (referent=Ser/Ser and Ser/Leu). This risk increase was consistent by cell lineage (B- and T-cell NHL) and pronounced for the two most common subtypes, diffuse large B-cell (OR=3.4, 95% CI=1.5-7.8) and follicular lymphoma (OR=2.6, 95% CI=1.0-6.8). In an analysis of manganese superoxide dismutase (SOD2 Val16Ala, rs1799725) Ala/Ala homozygotes, we observed moderately increased risks for B-cell lymphomas (OR=1.3, 95% CI=1.0-1.6; referent=Val/Val and Val/Ala) that was consistent across the B-cell subtypes. Genetic variations that result in an increased generation of reactive oxygen species appear to increase risk for NHL and its major subtypes, particularly DLBCL. Independent replication of our findings are warranted and further evaluation of oxidative stress in the context of inflammation, DNA repair and the induction of the NF-kappaB pathway may further reveal important clues for lymphomagenesis. JF - Carcinogenesis AU - Wang, Sophia S AU - Davis, Scott AU - Cerhan, James R AU - Hartge, Patricia AU - Severson, Richard K AU - Cozen, Wendy AU - Lan, Qing AU - Welch, Robert AU - Chanock, Stephen J AU - Rothman, Nathaniel AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. wangso@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1828 EP - 1834 VL - 27 IS - 9 SN - 0143-3334, 0143-3334 KW - NF-kappa B KW - 0 KW - Reactive Oxygen Species KW - Index Medicus KW - Risk KW - Polymorphism, Single Nucleotide KW - DNA Repair KW - Humans KW - Oxidative Stress KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - NF-kappa B -- metabolism KW - Lymphoma, Non-Hodgkin -- metabolism KW - Lymphoma, Non-Hodgkin -- genetics KW - Polymorphism, Genetic KW - Genetic Predisposition to Disease UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68763347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Polymorphisms+in+oxidative+stress+genes+and+risk+for+non-Hodgkin+lymphoma.&rft.au=Wang%2C+Sophia+S%3BDavis%2C+Scott%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BSeverson%2C+Richard+K%3BCozen%2C+Wendy%3BLan%2C+Qing%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel&rft.aulast=Wang&rft.aufirst=Sophia&rft.date=2006-09-01&rft.volume=27&rft.issue=9&rft.spage=1828&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-16 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Complementary and alternative medicine research and cooperative groups: can it happen? AN - 68729912; 16902079 AB - The use of complementary and alternative medicine (CAM) interventions to ameliorate cancer- and treatment-related toxicities is gaining increasing attention among clinical investigators. The National Cancer Institute supports a number of clinical studies, both descriptive and interventional, of CAM interventions across the cancer trajectory, from prevention through diagnosis and treatment, survivorship, and end of life. This report highlights the unique challenges that clinical investigators face when designing and implementing CAM clinical trials through the cooperative groups. This report focuses on 2 CAM trials that opened and accrued participants in the Children's Oncology Group. One trial is aimed at preventing or reducing mucositis and the other at preventing chemotherapy-induced nausea and vomiting. JF - Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses AU - O'Mara, Ann AD - National Cancer Institute, National Institutes of Health, 6130 Executive Blvd., EPN 2010, Bethesda, MD 20892, USA. omaraa@MAIL.NIH.GOV PY - 2006 SP - 258 EP - 260 VL - 23 IS - 5 SN - 1043-4542, 1043-4542 KW - Index Medicus KW - Nursing KW - United States KW - Nausea -- etiology KW - Nausea -- prevention & control KW - Humans KW - Stomatitis -- etiology KW - Medical Oncology -- organization & administration KW - Child KW - Patient Care Team -- organization & administration KW - Research Personnel KW - Neoplasms -- complications KW - Pediatric Nursing -- organization & administration KW - Oncology Nursing -- organization & administration KW - National Institutes of Health (U.S.) KW - Pediatrics -- organization & administration KW - Stomatitis -- prevention & control KW - Cooperative Behavior KW - Complementary Therapies -- standards KW - Research Design KW - Interprofessional Relations KW - Clinical Trials as Topic -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68729912?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+pediatric+oncology+nursing+%3A+official+journal+of+the+Association+of+Pediatric+Oncology+Nurses&rft.atitle=Complementary+and+alternative+medicine+research+and+cooperative+groups%3A+can+it+happen%3F&rft.au=O%27Mara%2C+Ann&rft.aulast=O%27Mara&rft.aufirst=Ann&rft.date=2006-09-01&rft.volume=23&rft.issue=5&rft.spage=258&rft.isbn=&rft.btitle=&rft.title=Journal+of+pediatric+oncology+nursing+%3A+official+journal+of+the+Association+of+Pediatric+Oncology+Nurses&rft.issn=10434542&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-08-11 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit. AN - 68725266; 16835771 AB - The ionotropic NMDA glutamate receptor is composed of NR1 and NR2 (NR2A-D) subunits. While there is compelling evidence that NMDA receptors modulate behavioral effects of ethanol, there is little understanding of how the subunit composition of the NMDA receptor mediates these effects. In the current study, we assessed the relative roles of NMDA subunits via phenotypic assessment of ethanol-related behaviors in NR2A knockout (KO) mice. Results demonstrated that NR2A KO and heterozygous mice failed to show evidence of ethanol-induced conditioned place preference. As compared to wild-type (WT) controls, KO mice showed impaired motor coordination at baseline and, in some instances, following ethanol treatment on the accelerating rotarod, balance beam, and wire-hang tests. By contrast, open field locomotor-stimulant, sedative/hypnotic, and hypothermic responses to ethanol were not different between genotypes, nor was voluntary ethanol consumption and preference in a two-bottle choice paradigm. Blood ethanol concentrations were lower in KO than WT mice following intraperitoneal ethanol injection. Results suggest that the loss of NR2A subunit-containing NMDA receptors impairs the ability to form or express learned reward-related responses to ethanol and causes deficits in motor coordination. However, the loss of NR2A does not alter other measures of acute ethanol intoxication or ethanol consumption, possibly implicating other NMDA subunits in these effects. These data provide novel insight into the role of NMDA receptors in modulating the behavioral effects of ethanol. JF - Psychopharmacology AU - Boyce-Rustay, Janel M AU - Holmes, Andrew AD - Section on Behavioral Science and Genetics, Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852, USA. janel.boyce-rustay@abbott.com Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 455 EP - 466 VL - 187 IS - 4 SN - 0033-3158, 0033-3158 KW - Central Nervous System Depressants KW - 0 KW - NR2A NMDA receptor KW - Receptors, N-Methyl-D-Aspartate KW - Ethanol KW - 3K9958V90M KW - Index Medicus KW - Animals KW - Sleep -- drug effects KW - Dose-Response Relationship, Drug KW - Anxiety -- chemically induced KW - Mice, Inbred C57BL KW - Hypothermia -- chemically induced KW - Motor Activity -- drug effects KW - Mice KW - Time Factors KW - Mice, Knockout KW - Alcohol Drinking -- metabolism KW - Conditioning, Classical -- drug effects KW - Alcohol Drinking -- blood KW - Receptors, N-Methyl-D-Aspartate -- metabolism KW - Ethanol -- metabolism KW - Behavior, Animal -- drug effects KW - Ethanol -- adverse effects KW - Ethanol -- blood KW - Central Nervous System Depressants -- adverse effects KW - Central Nervous System Depressants -- blood KW - Central Nervous System Depressants -- metabolism KW - Motor Skills -- drug effects KW - Receptors, N-Methyl-D-Aspartate -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68725266?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Ethanol-related+behaviors+in+mice+lacking+the+NMDA+receptor+NR2A+subunit.&rft.au=Boyce-Rustay%2C+Janel+M%3BHolmes%2C+Andrew&rft.aulast=Boyce-Rustay&rft.aufirst=Janel&rft.date=2006-09-01&rft.volume=187&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-02 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancer risks following diagnostic and therapeutic radiation exposure in children. AN - 68723555; 16862418 AB - The growing use of interventional and fluoroscopic imaging in children represents a tremendous benefit for the diagnosis and treatment of benign conditions. Along with the increasing use and complexity of these procedures comes concern about the cancer risk associated with ionizing radiation exposure to children. Children are considerably more sensitive to the carcinogenic effects of ionizing radiation than adults, and children have a longer life expectancy in which to express risk. Numerous epidemiologic cohort studies of childhood exposure to radiation for treatment of benign diseases have demonstrated radiation-related risks of cancer of the thyroid, breast, brain and skin, as well as leukemia. Many fewer studies have evaluated cancer risk following diagnostic radiation exposure in children. Although radiation dose for a single procedure might be low, pediatric patients often receive repeated examinations over time to evaluate their conditions, which could result in relatively high cumulative doses. Several cohort studies of girls and young women subjected to multiple diagnostic radiation exposures have been informative about increased mortality from breast cancer with increasing radiation dose, and case-control studies of childhood leukemia and postnatal diagnostic radiation exposure have suggested increased risks with an increasing number of examinations. Only two long-term follow-up studies of cancer following cardiac catheterization in childhood have been conducted, and neither reported an overall increased risk of cancer. Most cancers can be induced by radiation, and a linear dose-response has been noted for most solid cancers. Risks of radiation-related cancer are greatest for those exposed early in life, and these risks appear to persist throughout life. JF - Pediatric radiology AU - Kleinerman, Ruth A AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, EPS 7044, 6120 Executive Blvd., Rockville, MD 20852, USA. kleinerr@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 121 EP - 125 VL - 36 Suppl 2 KW - Index Medicus KW - United States KW - Radiation KW - Humans KW - Body Burden KW - Incidence KW - Child KW - Environmental Exposure -- statistics & numerical data KW - Neoplasms, Radiation-Induced -- epidemiology KW - Radiography -- statistics & numerical data KW - Risk Assessment -- methods KW - Radiotherapy -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68723555?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+radiology&rft.atitle=Cancer+risks+following+diagnostic+and+therapeutic+radiation+exposure+in+children.&rft.au=Kleinerman%2C+Ruth+A&rft.aulast=Kleinerman&rft.aufirst=Ruth&rft.date=2006-09-01&rft.volume=36+Suppl+2&rft.issue=&rft.spage=121&rft.isbn=&rft.btitle=&rft.title=Pediatric+radiology&rft.issn=1432-1998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Environ Health Perspect. 2000 Jun;108(6):495-8 [10856021] Radiat Res. 1994 Dec;140(3):334-9 [7972685] Int J Epidemiol. 2000 Jun;29(3):424-8 [10869313] Spine (Phila Pa 1976). 2000 Aug 15;25(16):2052-63 [10954636] Cancer Epidemiol Biomarkers Prev. 2002 Feb;11(2):177-85 [11867505] Radiat Res. 2002 Apr;157(4):410-8 [11893243] Radiat Res. 2002 Aug;158(2):220-35 [12105993] Health Phys. 2003 Jul;85(1):47-59 [12852471] J Natl Cancer Inst. 1977 Sep;59(3):823-32 [894747] Science. 1980 Sep 12;209(4462):1197-203 [7403879] Cancer Detect Prev. 1982;5(2):175-8 [7127341] Pediatrics. 1983 Feb;71(2):235-9 [6823426] Am J Epidemiol. 1988 Apr;127(4):713-25 [3354538] Cancer. 1988 Aug 1;62(3):635-44 [3164642] N Engl J Med. 1988 Oct 20;319(16):1033-9 [3173432] N Engl J Med. 1989 Nov 9;321(19):1281-4 [2797100] N Engl J Med. 1989 Nov 9;321(19):1285-9 [2797101] Radiat Res. 1989 Dec;120(3):516-31 [2594972] Radiat Res. 1991 Mar;125(3):318-25 [2000456] Radiat Res. 1992 Jul;131(1):98-111 [1385649] Am J Epidemiol. 1993 May 15;137(10):1068-80 [8317436] J Clin Endocrinol Metab. 1993 Aug;77(2):362-9 [8345040] Int J Epidemiol. 1993 Aug;22(4):584-91 [8225729] Radiat Res. 1995 Mar;141(3):259-77 [7871153] Acta Oncol. 1995;34(6):735-40 [7576739] Radiat Res. 1996 May;145(5):595-601 [8619025] Radiat Res. 1996 Jun;145(6):694-707 [8643829] Radiat Res. 1998 Sep;150(3):357-64 [9728664] Radiat Res. 1999 May;151(5):626-32 [10319736] Radiat Res. 2005 Apr;163(4):424-32 [15799699] Comment In: Pediatr Radiol. 2007 Jan;37(1):109-11 [17043854] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Radiation dose and cancer risk among pediatric patients undergoing interventional neuroradiology procedures. AN - 68722489; 16862414 AB - During interventional neuroradiology procedures, patients can be exposed to moderate to high levels of radiation. Special considerations are required to protect children, who are generally more sensitive to the short- and long-term detrimental effects of radiation exposure. Estimates of dose to the skin of children from certain interventional procedures have been published elsewhere, but we are not aware of data on dose to the brain or on the long-term risk of cancer from brain radiation. Our goals were to estimate radiation doses to the brain in 50 pediatric patients who had undergone cerebral embolization and to assess their lifetime risks of developing radiation-related brain cancer. Entrance-peak skin dose and various assumptions on conditions of exposure were used as input for dosimetric calculations to estimate the spatial pattern of dose within the brain and the average dose to the whole brain for each child. The average dose and the age of the child at time of exposure were used to estimate the lifetime risk of developing radiation-related brain cancer. Among the 50 patients, average radiation doses to the brain were estimated to vary from 100 mGy to 1,300 mGy if exposed to non-collimated fields and from 20 mGy to 160 mGy for collimated, moving fields. The lifetime risk of developing brain cancer was estimated to be increased by 2% to 80% as a result of the exposure. Given the very small lifetime background risk of brain tumor, the excess number of cases will be small even though the relative increase might be as high as 80%. ALARA principles of collimation and dose optimization are the most effective means to minimize the risk of future radiation-related cancer. JF - Pediatric radiology AU - Thierry-Chef, Isabelle AU - Simon, Steven L AU - Miller, Donald L AD - Radiation Epidemiology Branch, Division of Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 159 EP - 162 VL - 36 Suppl 2 KW - Index Medicus KW - Young Adult KW - Humans KW - Infant, Newborn KW - Child KW - Risk Assessment -- methods KW - Child, Preschool KW - Infant KW - Relative Biological Effectiveness KW - Risk Factors KW - Adult KW - Incidence KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Neuroradiography -- statistics & numerical data KW - Brain Neoplasms -- epidemiology KW - Neoplasms, Radiation-Induced -- epidemiology KW - Body Burden KW - Radiography, Interventional -- statistics & numerical data KW - Radiometry -- statistics & numerical data UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68722489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+radiology&rft.atitle=Radiation+dose+and+cancer+risk+among+pediatric+patients+undergoing+interventional+neuroradiology+procedures.&rft.au=Thierry-Chef%2C+Isabelle%3BSimon%2C+Steven+L%3BMiller%2C+Donald+L&rft.aulast=Thierry-Chef&rft.aufirst=Isabelle&rft.date=2006-09-01&rft.volume=36+Suppl+2&rft.issue=&rft.spage=159&rft.isbn=&rft.btitle=&rft.title=Pediatric+radiology&rft.issn=1432-1998&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2009-06-19 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Phys Med Biol. 1983 Jan;28(1):1-18 [6828554] J Nucl Med. 1999 Mar;40(3):62S-101S [10086719] J Nucl Med. 1999 Aug;40(8):1327-36 [10450685] J Vasc Interv Radiol. 2004 Sep;15(9):919-26 [15361559] J Vasc Interv Radiol. 2003 Jun;14(6):711-27 [12817038] J Vasc Interv Radiol. 2003 Aug;14(8):977-90 [12902555] Phys Med Biol. 1981 Jul;26(4):657-70 [7255547] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms. AN - 68701120; 16545872 AB - Alcoholism is a major public health problem and resembles, in many ways, other chronic relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer targetable pathophysiological mechanisms. Systems that mediate positive reinforcement by alcohol are likely important targets in early stages of the disease, particularly in genetically susceptible individuals. In contrast, long term neuroadaptive changes caused by chronic alcohol use primarily appear to affect systems mediating negative affective states, and gain importance following a prolonged history of dependence. Feasibility of pharmacological treatment in alcoholism has been demonstrated by a first wave of drugs which consists of 3 currently approved medications, the aldehyde dehydrogenase blocker disulfiram, the opioid antagonist naltrexone (NTX) and the functional glutamate antagonist acamprosate (ACM). The treatment toolkit is likely to be expanded in the near future. This will improve overall efficacy and allow individualized treatment, ultimately taking in account the patient's genetic makeup. In a second wave, early human efficacy data are available for the 5HT3 antagonist ondansetron, the GABA-B agonist baclofen and the anticonvulsant topiramate. The third wave is comprised of compounds predicted to be effective based on a battery of animal models. Using such models, a short list of additional targets has accumulated sufficient preclinical validation to merit clinical development. These include the cannabinoid CB1 receptor, receptors modulating glutamatergic transmission (mGluR2, 3 and 5), and receptors for stress-related neuropeptides corticotropin releasing factor (CRF), neuropeptide Y (NPY) and nociceptin. Once novel treatments are developed, the field faces a major challenge to assure their delivery to patients. JF - Pharmacology & therapeutics AU - Heilig, Markus AU - Egli, Mark AD - National Institute on Alcohol Abuse and Alcoholism/NIH/DHHS, 10 Center Drive, 10/1E-5334 Bethesda, MD 20892-1610, United States. markus.heilig@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 855 EP - 876 VL - 111 IS - 3 SN - 0163-7258, 0163-7258 KW - Alcohol Deterrents KW - 0 KW - Neuropeptide Y KW - Opioid Peptides KW - Receptor, Cannabinoid, CB1 KW - Receptor, Metabotropic Glutamate 5 KW - Receptors, Metabotropic Glutamate KW - metabotropic glutamate receptor 2 KW - topiramate KW - 0H73WJJ391 KW - Taurine KW - 1EQV5MLY3D KW - Fructose KW - 30237-26-4 KW - Ondansetron KW - 4AF302ESOS KW - Naltrexone KW - 5S6W795CQM KW - nociceptin KW - 7AYI9N34FF KW - Corticotropin-Releasing Hormone KW - 9015-71-8 KW - Baclofen KW - H789N3FKE8 KW - acamprosate KW - N4K14YGM3J KW - Disulfiram KW - TR3MLJ1UAI KW - Index Medicus KW - Animals KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Fructose -- analogs & derivatives KW - Ondansetron -- therapeutic use KW - Humans KW - Disease Models, Animal KW - Taurine -- therapeutic use KW - Fructose -- therapeutic use KW - Neuropeptide Y -- physiology KW - Baclofen -- therapeutic use KW - Naltrexone -- therapeutic use KW - Taurine -- analogs & derivatives KW - Opioid Peptides -- physiology KW - Disulfiram -- therapeutic use KW - Corticotropin-Releasing Hormone -- antagonists & inhibitors KW - Receptors, Metabotropic Glutamate -- agonists KW - Receptors, Metabotropic Glutamate -- antagonists & inhibitors KW - Alcoholism -- physiopathology KW - Alcoholism -- drug therapy KW - Alcohol Deterrents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68701120?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacology+%26+therapeutics&rft.atitle=Pharmacological+treatment+of+alcohol+dependence%3A+target+symptoms+and+target+mechanisms.&rft.au=Heilig%2C+Markus%3BEgli%2C+Mark&rft.aulast=Heilig&rft.aufirst=Markus&rft.date=2006-09-01&rft.volume=111&rft.issue=3&rft.spage=855&rft.isbn=&rft.btitle=&rft.title=Pharmacology+%26+therapeutics&rft.issn=01637258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of eosinophil generation and migration by Mangifera indica L. extract (Vimang). AN - 68653517; 16846846 AB - The effects of Vimang, an aqueous extract of the stem bark of Mangifera indica L. (Anacardiaceae), on cell migration in an experimental model of asthma was investigated. In vivo treatment of Toxocara canis-infected BALB/c mice for 18 days with 50 mg/kg Vimang reduced eosinophil migration into the bronchoalveolar space and peritoneal cavity. Also, eosinophil generation in bone marrow and blood eosinophilia were inhibited in infected mice treated with Vimang. This reduction was associated with inhibition of IL-5 production in serum and eotaxin in lung homogenates. In all these cases the effects of Vimang were more selective than those observed with dexamethasone. Moreover, Vimang treatment is not toxic for the animals, as demonstrated by the normal body weight increase during infection. These data confirm the potent anti-inflammatory effect of Vimang and support its potential use as an alternative therapeutic drug to the treatment of eosinophilic disorders including those caused by nematodes and allergic diseases. JF - International immunopharmacology AU - Sá-Nunes, Anderson AU - Rogerio, Alexandre P AU - Medeiros, Alexandra I AU - Fabris, Viciany E AU - Andreu, Gilberto P AU - Rivera, Dagmar G AU - Delgado, René AU - Faccioli, Lúcia H AD - Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14040-903 SP, Brazil. anunes@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1515 EP - 1523 VL - 6 IS - 9 SN - 1567-5769, 1567-5769 KW - Mangifera indica extract KW - 0 KW - Plant Extracts KW - Index Medicus KW - Animals KW - Toxocara canis -- immunology KW - Body Weight -- drug effects KW - Mangifera KW - Disease Models, Animal KW - Mice KW - Mice, Inbred BALB C KW - Leukocyte Count KW - Plant Extracts -- pharmacology KW - Phytotherapy KW - Toxocariasis -- immunology KW - Toxocariasis -- drug therapy KW - Cell Movement -- immunology KW - Plant Extracts -- therapeutic use KW - Eosinophils -- drug effects KW - Eosinophils -- cytology KW - Cell Movement -- drug effects KW - Toxocariasis -- pathology KW - Cell Differentiation -- drug effects KW - Eosinophils -- immunology KW - Cell Differentiation -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68653517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+immunopharmacology&rft.atitle=Modulation+of+eosinophil+generation+and+migration+by+Mangifera+indica+L.+extract+%28Vimang%29.&rft.au=S%C3%A1-Nunes%2C+Anderson%3BRogerio%2C+Alexandre+P%3BMedeiros%2C+Alexandra+I%3BFabris%2C+Viciany+E%3BAndreu%2C+Gilberto+P%3BRivera%2C+Dagmar+G%3BDelgado%2C+Ren%C3%A9%3BFaccioli%2C+L%C3%BAcia+H&rft.aulast=S%C3%A1-Nunes&rft.aufirst=Anderson&rft.date=2006-09-01&rft.volume=6&rft.issue=9&rft.spage=1515&rft.isbn=&rft.btitle=&rft.title=International+immunopharmacology&rft.issn=15675769&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-05 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glutathione S-transferase GSTM1 and GSTT1 polymorphisms in adult acute myeloid leukemia; its impact on toxicity and response to chemotherapy. AN - 68344741; 17671537 AB - Heterogeneity in patient' s response to chemotherapy is consistently observed across populations. Pharmacogenomics, the study of inherited differences in drug disposition and effects, is emerging as a tool to predict efficacy and toxicity of drugs. Glutathione S-transferases (GST) are involved in the metabolism and detoxification of environmental carcinogens and some classes of chemotherapeutics. Polymorphism of GSTM1 and GSTT1, in the form of homozygous deletion, is encountered in varying frequencies in normal population. It has been associated with altered response and toxicity from cytotoxic chemotherapy. In this study, we investigated the impact of these polymorphisms on response and side effects of chemotherapy in adult acute myeloid leukaemia (AML) patients. Correlations between these genetic polymorphisms and other prognostic factors were also investigated. We genotyped GSTM1 and GSTT1 in 98 adult AML patients using multiplex PCR. Induction therapy included Doxorubicin and Cytosine arabinoside (3+7) regimen. Treatment outcomes were compared in those with or without GSTM1 and GSTT1 genes. The frequencies of GSTM1 null and GSTT1 null genotypes were 56% and 14%, respectively. Six percent (6%) were double null. The rate of toxic death during induction was 3/7 (43%) and 17/56 (30%) in GSTT1 null and GSTT1 present patients, respectively, p=0.67. This constituted 75% and 42% of total deaths in each group, respectively, p=0.31. Differences were not statistically significant. On the other hand, the rate of complete remission (CR) in patients with GSTM1 present compared to those with GSTM1 null genotype was 12/27 (48%) versus 23/36 (64%), p=0.21. GSTT1 null genotype was significantly associated with lymphoid marker (mainly CD7) expression (p=0.03), known with its adverse effect on prognosis. Overall survival and disease-free survival were similar in patients with and without the genes. No significant associations were encountered between GST genotypes and treatment outcomes. Our data suggest possible association, though not significant, between GSTT1 null genotype and toxic death during induction and between GSTM1 present genotype and lower rate of CR. Studies on larger numbers are needed focusing on selection of anticancer agents to avoid adverse reactions and therapeutic failure, with special emphasis on drug toxicity and dose adjustment. JF - Journal of the Egyptian National Cancer Institute AU - Mossallam, Ghada I AU - Abdel Hamid, Thoraya M AU - Samra, Mohamed A AD - Department of Clinical Pathology, National Cancer Institute, Cairo University, Egypt. ghadamossallam@hotmail.com Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 264 EP - 273 VL - 18 IS - 3 SN - 1110-0362, 1110-0362 KW - Antineoplastic Agents KW - 0 KW - glutathione S-transferase T1 KW - EC 2.5.1.- KW - Glutathione Transferase KW - EC 2.5.1.18 KW - Index Medicus KW - Acute Disease KW - Treatment Failure KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Male KW - Female KW - Leukemia, Myeloid -- drug therapy KW - Polymorphism, Genetic KW - Leukemia, Myeloid -- enzymology KW - Glutathione Transferase -- genetics KW - Antineoplastic Agents -- therapeutic use KW - Leukemia, Myeloid -- mortality KW - Antineoplastic Agents -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68344741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Glutathione+S-transferase+GSTM1+and+GSTT1+polymorphisms+in+adult+acute+myeloid+leukemia%3B+its+impact+on+toxicity+and+response+to+chemotherapy.&rft.au=Mossallam%2C+Ghada+I%3BAbdel+Hamid%2C+Thoraya+M%3BSamra%2C+Mohamed+A&rft.aulast=Mossallam&rft.aufirst=Ghada&rft.date=2006-09-01&rft.volume=18&rft.issue=3&rft.spage=264&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gemcitabine plus doxorubicin as first-line treatment in advanced or metastatic breast cancer (MBC), a phase II study. AN - 68344705; 17671530 AB - Doxorubicin and Gemcitabine have promising antineoplastic activity and manageable toxicity as a single agent in the treatment of patients (pts) with advanced breast cancer. This study evaluated the efficacy and toxicity of the combination of gemcitabine plus doxorubicin as first-line treatment of advanced or MBC patients. Patients with advanced or MBC received gemcitabine 1250mg/m2 IV on days 1 and 8 plus doxorubicin 60mg/m2 IV on day 1 every 21 days for a maximum of 6 cycles. Thirty-five patients were included, and all are evaluable for safety and efficacy. Median age was 47 years (range, 33 to 60 years). Fourteen patients (40%) were post-and 21 (60%) were premenopausal. Prior treatment included mastectomy (23pts); adjuvant nonanthracycline containing combination chemotherapy (18pts); adjuvant hormonal therapy (3pts) and 2 pts did not receive any adjuvant therapy. Twelve patients had metastatic disease at presentation. Seventeen pts were chemonaive. Hormonal receptors were positive in 6, negative in 21, and unknown in 8 pts. Site of metastasis included one site in 15 pts, two sites in 14, and three sites in 6 pts. Complete remission was observed in 6/35 (17.1%) and partial remission in 14/35 (40%) pts, for an overall response rate of 57.1%. Stable disease was observed in 8 (22.9%) and progressive disease in 7 (20%) pts. The median time to tumor progression was 7 months (range, 5-23 months; 95% CI, 6-8 months) and the median survival time was 16 months (range, 6-43 months; 95% CI, 13-19 months). The overall survival at 1 and 2 years was 74.2% and 34.2%; respectively; with 4/35 (11.4%) patients alive at 40 months. A total of 186 cycles of treatment were administered (range2-6 cycles, median 6 cycles). The doses of both doxorubicin and gemcitabine were modified after interim analysis of toxicity following the first 22 cycles administered to the first 10 patients [Mucositis grade 3-4 occurred in 6/10 (60%), grade 3-4 neutropenia in 3/10 (30%), and febrile neutropenia grade 3 in 2/10 (20%) patients] to doxorubicin 50mg/m2 on day 1 and gemcitabine to 1000 mg/m2 on days 1 and 8 in the remaining cycles. After doses reduction, the toxicity was generally tolerable. The combination of gemcitabine plus doxorubicin after doses modification can be safely administered every 21 days with promising response as first-line therapy for MBC. The response rate, time to disease progression and overall survival rates of this regimen are comparable to other standard therapies for MBC, as well as other gemcitabine combinations. JF - Journal of the Egyptian National Cancer Institute AU - El Serafi, Moustafa M AU - El Khodary, Ahmed I AU - El Zawahry, Heba R AU - Mansour, Osman M AU - Gaballa, Hussein E AD - The Department of Medical Oncology, National Cancer Institute, Cairo University, Egypt. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 209 EP - 215 VL - 18 IS - 3 SN - 1110-0362, 1110-0362 KW - Deoxycytidine KW - 0W860991D6 KW - Doxorubicin KW - 80168379AG KW - gemcitabine KW - B76N6SBZ8R KW - Index Medicus KW - Doxorubicin -- adverse effects KW - Deoxycytidine -- adverse effects KW - Humans KW - Deoxycytidine -- analogs & derivatives KW - Adult KW - Treatment Outcome KW - Deoxycytidine -- administration & dosage KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Female KW - Breast Neoplasms -- drug therapy KW - Breast Neoplasms -- mortality KW - Breast Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68344705?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Gemcitabine+plus+doxorubicin+as+first-line+treatment+in+advanced+or+metastatic+breast+cancer+%28MBC%29%2C+a+phase+II+study.&rft.au=El+Serafi%2C+Moustafa+M%3BEl+Khodary%2C+Ahmed+I%3BEl+Zawahry%2C+Heba+R%3BMansour%2C+Osman+M%3BGaballa%2C+Hussein+E&rft.aulast=El+Serafi&rft.aufirst=Moustafa&rft.date=2006-09-01&rft.volume=18&rft.issue=3&rft.spage=209&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Locally advanced rectal carcinoma: preoperative radiotherapy versus postoperative chemoradiation, 10-year follow-up results of a randomized clinical study. AN - 68343422; 17671533 AB - A prospective study was designed to randomize locally advanced rectal carcinoma patients between either preoperative radiotherapy (+/- postoperative chemotherapy) or postoperative adjuvant chemoradiation. Two end points were evaluated, local recurrence and survival, aiming at defining prognostic parameters that can help in the choice of the optimum treatment modality. This is a prospective randomized clinical study including patients with locally advanced low rectal cancer treated at the National Cancer Institute (NCI), Cairo University, during the period from December 1994 to January 1999. Fifty patients with previously untreated rectal cancer were randomized into two groups, Group I: Subjected to surgery followed by radiation therapy (50Gy/5 weeks, 2Gy/fraction, 5 days/week) plus chemotherapy and Group II, subjected to preoperative radiotherapy (46Gy/4.5 weeks, 2Gy/ fraction, 5 days/week) followed by surgery +/- postoperative chemotherapy. Chemotherapy in the concomitant setting was given in the form of Leucovorin in a dose of 300mg/m2 as a short i.v. infusion followed by 5-FU in a dose of 350mg/m2 as a 6 hour i.v. infusion, whereas adjuvant chemotherapy consisted of 5- FU as 600mg/m2 short i.v. infusion weekly for 48 weeks, in addition to levamisole tablets. The long-term treatment end results obtained showed that group I patients had a slightly higher 10-year overall survival (OS) rate when compared to group II patients (63% versus 60%, p=0.698). The corresponding figures for the 10-year disease-free survival (DFS) were 65% and 66%, respectively, p=0.816. Although the 10- year local failure rate (persistent/relapsed disease) was higher for the preoperative group, it was not of statistical significance, (30% Vs. 8%, p=0.057). On the other hand, the 10-year distant metastasis free survival was higher in the preoperative group (88% Vs. 72%), yet this difference did not reach statistical significance (p=0.16). The rate of acute radiation reactions was higher in the postoperative group, with no increase in the operative complications in the preoperative group. Moreover, none of the 50 patients had grade 3 or more late radiation/surgical squealae. There were no grade 3 or 4 chemotherapy related toxicities. This work showed equal results for DFS and OS rates between preoperative and postoperative radiation therapy with the same acceptable acute and late radiation toxicity. High dose preoperative irradiation did not cause any significant increase in acute or late radiation induced reactions, delay in wound healing or increased postoperative morbidity when compared to postoperative adjuvant radiochemotherapy. Duke' s stage and response to preoperative irradiation proved to be of significance regarding DFS, while compliance to systemic therapy was of significance regarding both OS and DFS. JF - Journal of the Egyptian National Cancer Institute AU - Taher, Azza N AU - El-Baradie, Manal M AU - Nasr, Azza M AU - Khorshid, Ola AU - Morsi, Ahmed AU - Hamza, Mohamad Reda AU - Mokhtar, Nadia AU - Ezzat, Somaia AD - Department of Radiation Oncology & Nuclear Medicine,National Cancer Institute, Cairo University, Egypt. ataher3@yahoo.com Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 233 EP - 243 VL - 18 IS - 3 SN - 1110-0362, 1110-0362 KW - Index Medicus KW - Radiotherapy, Adjuvant KW - Humans KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Rectal Neoplasms -- mortality KW - Preoperative Care KW - Carcinoma -- surgery KW - Rectal Neoplasms -- surgery KW - Rectal Neoplasms -- radiotherapy KW - Postoperative Care KW - Carcinoma -- radiotherapy KW - Carcinoma -- mortality UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68343422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Egyptian+National+Cancer+Institute&rft.atitle=Locally+advanced+rectal+carcinoma%3A+preoperative+radiotherapy+versus+postoperative+chemoradiation%2C+10-year+follow-up+results+of+a+randomized+clinical+study.&rft.au=Taher%2C+Azza+N%3BEl-Baradie%2C+Manal+M%3BNasr%2C+Azza+M%3BKhorshid%2C+Ola%3BMorsi%2C+Ahmed%3BHamza%2C+Mohamad+Reda%3BMokhtar%2C+Nadia%3BEzzat%2C+Somaia&rft.aulast=Taher&rft.aufirst=Azza&rft.date=2006-09-01&rft.volume=18&rft.issue=3&rft.spage=233&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Egyptian+National+Cancer+Institute&rft.issn=11100362&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-09-25 N1 - Date created - 2007-08-02 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression alterations in immune system pathways following exposure to immunosuppressive chemicals. AN - 68169218; 17119249 AB - Exposure to environmental agents can affect a number of adverse immunological outcomes, including changes in the incidence of infectious disease. Diethylstilbestrol (DES), dexamethasone (DEX), cyclophosphamide, and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are immunosuppressive chemicals that can induce similar pathophysiological end points in the thymus; however, the mechanism of toxicity is different for each compound. We examined differential gene expression in the spleen and thymus following chemical exposure and correlated these changes with alterations in functional immune end points and our knowledge of the known mechanisms of action. RNA from the spleen and thymus has been analyzed using Illumina Sentrix arrays and BeadStudio software. Preliminary data suggest that DES induced the greatest number of gene changes in the spleen, while DEX induced the most changes in the thymus. In both spleen and thymus, genomic analysis revealed gene expression changes that were common to multiple chemicals and that may be associated with xenobiotic-induced immune system perturbations, including alterations in genes associated with apoptosis, antigen processing and presentation, and response to biotic stimulus. This was particularly evident in the thymus, where there were many similarities in the expression profiles, as well as gene alterations unique to a single compound. In contrast, expression profiles in spleen were more distinct. The category of genes most profoundly affected by all four chemicals was response to biotic stimulus: there were both clusters of genes modulated by multiple chemicals and genes altered by a single chemical. The distinct gene profiles may specifically relate to cellular targets and mechanism of action. JF - Annals of the New York Academy of Sciences AU - Patterson, Rachel M AU - Germolec, Dori R AD - National Institute of Environmental Health Sciences, Research Triangle Park, NC 27719, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 718 EP - 727 VL - 1076 SN - 0077-8923, 0077-8923 KW - Immunosuppressive Agents KW - 0 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Spleen -- metabolism KW - Thymus Gland -- metabolism KW - Mice KW - Spleen -- drug effects KW - Thymus Gland -- drug effects KW - Female KW - Gene Expression -- drug effects KW - Immunosuppressive Agents -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68169218?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Gene+expression+alterations+in+immune+system+pathways+following+exposure+to+immunosuppressive+chemicals.&rft.au=Patterson%2C+Rachel+M%3BGermolec%2C+Dori+R&rft.aulast=Patterson&rft.aufirst=Rachel&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=718&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-19 N1 - Date created - 2006-11-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator. AN - 68158464; 16855375 AB - Inactivation of the p53 pathway is a common feature of neoplasia. Dysregulation of the p53 pathway has been shown to involve mutations of p53, increased expression of the p53 inhibitor HDM-2, or epigenetic silencing of the p53 promoter. In multiple myeloma, a neoplasia of terminally differentiated B cells, p53 mutations and deletions are relatively rare and occur in late stage disease. Here, we show that the p53 promoter is hypermethylated in several multiple myeloma cell lines in comparison to normal plasma cells. Two cell lines containing mutant p53, Lp-1 and OPM-2, show a methylation pattern that suggests that they contain one methylated and one unmethylated mutant allele. Two other cell lines, KMS-11 and OPM-2, show hypermethylation of p53 with a lack of expression. In all cell lines tested, treatment with a demethylating agents results in higher expression of p53. Furthermore, following increased expression of p53, treatment of the myeloma cell lines with a p53 activating peptide induces apoptosis. Therefore, combinatorial treatment with demethylating agents followed by delivery of a p53 activating peptide may be an effective therapeutic strategy against multiple myeloma. JF - Cancer biology & therapy AU - Hurt, Elaine M AU - Thomas, Suneetha B AU - Peng, Benjamin AU - Farrar, William L AD - Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland 21702, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1154 EP - 1160 VL - 5 IS - 9 SN - 1538-4047, 1538-4047 KW - Peptides KW - 0 KW - TP53 protein, human KW - Tumor Suppressor Protein p53 KW - retro-inverso-TATp53C' peptide KW - Cytidine KW - 5CSZ8459RP KW - pyrimidin-2-one beta-ribofuranoside KW - 7A9Y5SX0GY KW - Index Medicus KW - Tumor Suppressor Protein p53 -- biosynthesis KW - Promoter Regions, Genetic KW - Humans KW - Epigenesis, Genetic -- drug effects KW - DNA Methylation -- drug effects KW - Molecular Sequence Data KW - Cell Line, Tumor KW - Amino Acid Sequence KW - Tumor Suppressor Protein p53 -- genetics KW - Drug Synergism KW - Gene Silencing -- drug effects KW - Apoptosis -- genetics KW - Multiple Myeloma -- genetics KW - Cytidine -- genetics KW - Genes, p53 -- drug effects KW - Multiple Myeloma -- drug therapy KW - Multiple Myeloma -- pathology KW - Apoptosis -- drug effects KW - Cytidine -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Peptides -- pharmacology KW - Cytidine -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68158464?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+biology+%26+therapy&rft.atitle=Reversal+of+p53+epigenetic+silencing+in+multiple+myeloma+permits+apoptosis+by+a+p53+activator.&rft.au=Hurt%2C+Elaine+M%3BThomas%2C+Suneetha+B%3BPeng%2C+Benjamin%3BFarrar%2C+William+L&rft.aulast=Hurt&rft.aufirst=Elaine&rft.date=2006-09-01&rft.volume=5&rft.issue=9&rft.spage=1154&rft.isbn=&rft.btitle=&rft.title=Cancer+biology+%26+therapy&rft.issn=15384047&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-04-20 N1 - Date created - 2006-11-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Cancer Biol Ther. 2006 Sep;5(9):1161-2 [17012838] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gaps in knowledge in treating pregnant women. AN - 68107793; 17081950 AB - Because studies are often undertaken without knowledge of the pharmacokinetics of a drug, efficacy is difficult to assess in pregnant women. To address this lack, basic and clinical research within the National Institute of Child Health and Human Development is focusing on expanding knowledge of pharmacology during pregnancy. Although medication use, including prescription, over-the-counter, and herbal products, is common during pregnancy, physicians may not be aware of the nonprescription products their patients are taking or the interactions these products may have with prescribed medications. A number of studies have found sex differences in oxidative metabolism and transport, as well as pharmacologic and toxicologic differences in hepatic metabolism, that are ultimately reflected in pharmacokinetics. Sex differences exist in distribution volumes, transport proteins, and drug clearance. Beyond these sex differences, pregnancy itself affects the absorption, distribution, metabolism, and elimination of a drug. Women experience more adverse drug reactions (ADRs) than do men, and these reactions tend to be more severe. QT prolongation (torsades de pointes) and hepatic toxicity are two of the most severe ADRs, frequently causing withdrawal of a drug from the market. Women may also metabolize drugs more quickly than do men, and drugs metabolized by cytochrome P3A4 are cleared more rapidly during pregnancy. A substantial increase in the clearance of drugs eliminated by renal mechanisms also has been noted. A significant number of women are clinically depressed during pregnancy and postpartum, and eliminating treatment for depression during pregnancy may have negative consequences for both mother and fetus. Among women with depression who are treated with selective serotonin reuptake inhibitors, the dose needed to maintain efficacy increases across the course of pregnancy. Drug disposition and response not only can differ between men and women, but also between pregnant and nonpregnant women. Research is needed to understand how pregnancy alters the pharmacokinetics and pharmacodynamics of drugs; then, efficacy trials can be initiated. Alternative strategies also need to be developed to characterize safety information. JF - Gender medicine AU - Mattison, Donald AU - Zajicek, Anne AD - Obstetric and Pediatric Pharmacology Branch, Center for Research for Mothers and Children, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 169 EP - 182 VL - 3 IS - 3 SN - 1550-8579, 1550-8579 KW - Index Medicus KW - Sex Factors KW - Humans KW - Physician-Patient Relations KW - Female KW - Pregnancy KW - Patient Education as Topic -- standards KW - Health Knowledge, Attitudes, Practice UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68107793?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gender+medicine&rft.atitle=Gaps+in+knowledge+in+treating+pregnant+women.&rft.au=Mattison%2C+Donald%3BZajicek%2C+Anne&rft.aulast=Mattison&rft.aufirst=Donald&rft.date=2006-09-01&rft.volume=3&rft.issue=3&rft.spage=169&rft.isbn=&rft.btitle=&rft.title=Gender+medicine&rft.issn=15508579&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-11-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Changes in gene expression with increased transglutaminase 2 in a SH-SY5Y cell line. AN - 68002764; 16720350 AB - Previously we showed that the overexpression of transglutaminase 2 (TGase 2) resulted in activation of NF-kappaB through polymerization of I-kappaBalpha. To explore the pathway of TGase 2-mediated NF-kappaB activation, a transcriptomic microarray analysis was performed. In a SH-SY5Y cell line transfected with TGase 2, 24 genes were up-regulated at least 1.6-fold and 26 genes were down-regulated, as compared to the wild-type cell line. Detailed analysis resulted in the identification of target genes involved in regulating inflammation, including tribbles homolog 3, peroxiredoxin 4, neuropeptide Y, galanin, and vasoactive intestinal peptide. Our data demonstrate that the increase in TGase 2 in the neuroblastoma causes functional changes in transcriptional regulation, especially in genes associated with inflammation. These changes in gene expression caused by increases in TGase 2 activity may contribute to the pathophysiologic processes of inflammatory diseases. JF - Frontiers in bioscience : a journal and virtual library AU - Lee, Ju-Seog AU - Kim, In-Hoo AU - Kim, Soo-Youl AD - Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, MD, USA. Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 2774 EP - 2781 VL - 11 SN - 1093-9946, 1093-9946 KW - NF-kappa B KW - 0 KW - transglutaminase 2 KW - EC 2.3.2.- KW - Transglutaminases KW - EC 2.3.2.13 KW - GTP-Binding Proteins KW - EC 3.6.1.- KW - Index Medicus KW - Gene Expression Profiling KW - Blotting, Western KW - Tumor Cells, Cultured KW - Oligonucleotide Array Sequence Analysis KW - Down-Regulation KW - Transfection KW - Humans KW - Transcription, Genetic KW - Up-Regulation KW - NF-kappa B -- physiology KW - Neuroblastoma -- pathology KW - Neuroblastoma -- genetics KW - Inflammation -- physiopathology KW - GTP-Binding Proteins -- biosynthesis KW - Transglutaminases -- metabolism KW - GTP-Binding Proteins -- metabolism KW - Transglutaminases -- biosynthesis KW - Inflammation -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68002764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.atitle=Changes+in+gene+expression+with+increased+transglutaminase+2+in+a+SH-SY5Y+cell+line.&rft.au=Lee%2C+Ju-Seog%3BKim%2C+In-Hoo%3BKim%2C+Soo-Youl&rft.aulast=Lee&rft.aufirst=Ju-Seog&rft.date=2006-09-01&rft.volume=11&rft.issue=&rft.spage=2774&rft.isbn=&rft.btitle=&rft.title=Frontiers+in+bioscience+%3A+a+journal+and+virtual+library&rft.issn=10939946&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-06-27 N1 - Date created - 2006-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Characterization of T-cell repertoire in hairy cell leukemia patients before and after recombinant immunotoxin BL22 therapy. AN - 68000835; 16311729 AB - We previously reported that hairy cell leukemia (HCL) patients have high percentages of CD56+/CD57+/CD3+ large granular lymphocytes consistent with cytotoxic T-lymphocytes (CTLs), and other investigators have reported skewing of the T-cell repertoire. In previous studies of up to seven HCL patients, many of the 22 established T-cell receptor (TCR) beta variable region (TRBV) families showed mono- or oligoclonal restriction. To determine whether percentages of CTLs are correlated with TRBV clonal excess, we studied 20 HCL patients with flow cytometry, PCR of TCR gamma and TRBV regions, and fractional gel electrophoresis of PCR-amplified TRBV CDR3 domains (CDR3 spectratyping). Increased percentages of CD3+/CD8+/CD57+ CTLs correlated with more mono/oligoclonal and fewer polyclonal TRBV families (r=0.53; P=0.016). Age correlated with number of mono/oligoclonal TRBV families (r=0.51; P=0.022). Time since last purine analog therapy correlated with number of polyclonal TRBV families (r=0.46; P=0.040), but treatment with the anti-CD22 recombinant immunotoxin BL22 was not related to clonal excess. We conclude that abnormalities in the T-cell repertoire in HCL patients may represent deficient immunity, and may be exacerbated by purine analogs. Increased CD3+/CD57+ T-cells may be a useful marker of abnormal TRBV repertoire in HCL patients, and might prove useful in deciding whether patients should receive biologic antibody-based treatment rather than repeated courses of purine analog for relapsed disease. JF - Cancer immunology, immunotherapy : CII AU - Arons, Evgeny AU - Sorbara, Lynn AU - Raffeld, Mark AU - Stetler-Stevenson, Maryalice AU - Steinberg, Seth M AU - Liewehr, David J AU - Pastan, Ira AU - Kreitman, Robert J AD - Laboratories of Molecular Biology and Pathology, and Biostatistics and Data Management Section, Centers for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1100 EP - 1110 VL - 55 IS - 9 SN - 0340-7004, 0340-7004 KW - Antibodies KW - 0 KW - Antineoplastic Agents KW - Enterotoxins KW - Immunotoxins KW - RFB4(dsFv)-PE38 recombinant immunotoxin KW - Recombinant Proteins KW - Index Medicus KW - Humans KW - Aged KW - Gene Rearrangement, beta-Chain T-Cell Antigen Receptor KW - Genes, T-Cell Receptor beta KW - Leukocytes, Mononuclear -- classification KW - Base Sequence KW - Aged, 80 and over KW - Adult KW - Molecular Sequence Data KW - Flow Cytometry KW - Middle Aged KW - Recombinant Proteins -- therapeutic use KW - Female KW - Male KW - Antibodies -- therapeutic use KW - T-Lymphocyte Subsets -- classification KW - T-Lymphocyte Subsets -- drug effects KW - Leukemia, Hairy Cell -- drug therapy KW - Enterotoxins -- therapeutic use KW - Immunotoxins -- therapeutic use KW - Antineoplastic Agents -- therapeutic use KW - Leukemia, Hairy Cell -- immunology KW - Leukemia, Hairy Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68000835?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.atitle=Characterization+of+T-cell+repertoire+in+hairy+cell+leukemia+patients+before+and+after+recombinant+immunotoxin+BL22+therapy.&rft.au=Arons%2C+Evgeny%3BSorbara%2C+Lynn%3BRaffeld%2C+Mark%3BStetler-Stevenson%2C+Maryalice%3BSteinberg%2C+Seth+M%3BLiewehr%2C+David+J%3BPastan%2C+Ira%3BKreitman%2C+Robert+J&rft.aulast=Arons&rft.aufirst=Evgeny&rft.date=2006-09-01&rft.volume=55&rft.issue=9&rft.spage=1100&rft.isbn=&rft.btitle=&rft.title=Cancer+immunology%2C+immunotherapy+%3A+CII&rft.issn=03407004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-21 N1 - Date created - 2006-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Phase II trial of intravenous lobradimil and carboplatin in childhood brain tumors: a report from the Children's Oncology Group. AN - 68000535; 16408203 AB - [corrected] Lobradimil is a synthetic bradykinin analog that rapidly and transiently increases the permeability of the blood-brain barrier (BBB). The combination of lobradimil and carboplatin was studied in pediatric patients with primary brain tumors in a phase II trial, the primary endpoints of which were to estimate the response rate and time to disease progression. Patients were stratified by histology into five cohorts: brainstem glioma, high-grade glioma, low-grade glioma, medullobastoma/primitive neuroectodermal tumor (PNET), and ependymoma. Patients received carboplatin adaptively dosed to achieve a target AUC of 3.5 mg min/ml per day (7 mg.min/ml/cycle) intravenously over 15 min on 2 consecutive days and lobradimil 600 ng/kg ideal body weight/day on 2 consecutive days each 28 day cycle. Forty-one patients, age 2-19 years, were enrolled; 38 patients, including 1 patient ultimately determined to have atypical neurocytoma, were evaluable for response. No objective responses were observed in the brainstem glioma (n=12) and high-grade glioma (n = 9) cohorts, although two patients with high-grade glioma had prolonged disease stabilization (>6 months). The study was closed for commercial reasons prior to achieving the accrual goals for the ependymoma (n = 8), medulloblastoma/PNET (n = 6) and low-grade glioma (n = 2) cohorts, although responses were observed in 1 patient with PNET and 2 patients with ependymoma. The combination of lobradimil and carboplatin was inactive in childhood high-grade gliomas and brainstem gliomas. JF - Cancer chemotherapy and pharmacology AU - Warren, K AU - Jakacki, R AU - Widemann, B AU - Aikin, A AU - Libucha, M AU - Packer, R AU - Vezina, G AU - Reaman, G AU - Shaw, D AU - Krailo, M AU - Osborne, C AU - Cehelsky, J AU - Caldwell, D AU - Stanwood, J AU - Steinberg, S M AU - Balis, F M AD - National Cancer Institute/Neuro-Oncology Branch, Bethesda, MD 20892-8200, USA. warrenk@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 343 EP - 347 VL - 58 IS - 3 SN - 0344-5704, 0344-5704 KW - RMP 7 KW - 159768-75-9 KW - Carboplatin KW - BG3F62OND5 KW - Bradykinin KW - S8TIM42R2W KW - Index Medicus KW - Drug Administration Schedule KW - Infusions, Intravenous KW - Humans KW - Carboplatin -- therapeutic use KW - Child KW - Carboplatin -- administration & dosage KW - Carboplatin -- adverse effects KW - Bradykinin -- adverse effects KW - Child, Preschool KW - Bradykinin -- analogs & derivatives KW - Adult KW - Cohort Studies KW - Treatment Outcome KW - Bradykinin -- therapeutic use KW - Adolescent KW - Bradykinin -- administration & dosage KW - Brain Neoplasms -- drug therapy KW - Brain Neoplasms -- metabolism KW - Blood-Brain Barrier -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68000535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+chemotherapy+and+pharmacology&rft.atitle=Phase+II+trial+of+intravenous+lobradimil+and+carboplatin+in+childhood+brain+tumors%3A+a+report+from+the+Children%27s+Oncology+Group.&rft.au=Warren%2C+K%3BJakacki%2C+R%3BWidemann%2C+B%3BAikin%2C+A%3BLibucha%2C+M%3BPacker%2C+R%3BVezina%2C+G%3BReaman%2C+G%3BShaw%2C+D%3BKrailo%2C+M%3BOsborne%2C+C%3BCehelsky%2C+J%3BCaldwell%2C+D%3BStanwood%2C+J%3BSteinberg%2C+S+M%3BBalis%2C+F+M&rft.aulast=Warren&rft.aufirst=K&rft.date=2006-09-01&rft.volume=58&rft.issue=3&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Cancer+chemotherapy+and+pharmacology&rft.issn=03445704&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-05-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Mental health, quality of life, and nutritional status of adolescents in Dhaka, Bangladesh: Comparison between an urban slum and a non-urban area AN - 61601653; 200710241 AB - This study aims to clarify the quality of life (QOL), mental health, and nutritional status of adolescents in Dhaka city, Bangladesh by comparing non-slum areas and slums, and to find the factors associated with their mental health problems. A sample of 187 boys and 137 girls from non-slum areas, and 157 boys and 121 girls from slums, between 11-18 years old were interviewed with a questionnaire consisting of a Bangla translation of the World Health Organization Quality of Life Assessment Instrument (WHOQOL-BREF), Self Reporting Questionnaire (SRQ), Youth Self-Report (YSR) and other questions. The height and weight of the respondents were measured. All significant differences in demographic characteristics, anthropometric measures, and WHOQOL-BREF were found to reflect worse conditions in slum than in non-slum areas. Contrarily, all differences in SRQ and YSR were worse in non-slum areas for both genders, except that the "conduct problems" score for YSR was worse for slum boys. Mental states were mainly associated with school enrolment and working status. Worse physical environment and QOL were found in slums, along with gender and area specific mental health difficulties. The results suggest gender specific needs and a requirement for area sensitive countermeasures. [Copyright 2006 Elsevier Ltd.] JF - Social Science & Medicine AU - Izutsu, Takashi AU - Tsutsumi, Atsuro AU - Islam, Akramul Md AU - Kato, Seika AU - Wakai, Susumu AU - Kurita, Hiroshi AD - National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan, Tel.: +819093918888 E-mail addresses: izutsu@gakushikai.jp Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1477 EP - 1488 VL - 63 IS - 6 SN - 0277-9536, 0277-9536 KW - Bangladesh KW - Developing countries KW - Mental helath KW - Slum KW - Quality of life KW - Urbanization KW - Gender KW - Rural Communities KW - Quality of Life KW - Slums KW - Adolescents KW - Sex KW - 2460: policy, planning, forecasting; social indicators UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61601653?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+Science+%26+Medicine&rft.atitle=Mental+health%2C+quality+of+life%2C+and+nutritional+status+of+adolescents+in+Dhaka%2C+Bangladesh%3A+Comparison+between+an+urban+slum+and+a+non-urban+area&rft.au=Izutsu%2C+Takashi%3BTsutsumi%2C+Atsuro%3BIslam%2C+Akramul+Md%3BKato%2C+Seika%3BWakai%2C+Susumu%3BKurita%2C+Hiroshi&rft.aulast=Izutsu&rft.aufirst=Takashi&rft.date=2006-09-01&rft.volume=63&rft.issue=6&rft.spage=1477&rft.isbn=&rft.btitle=&rft.title=Social+Science+%26+Medicine&rft.issn=02779536&rft_id=info:doi/10.1016.%2Fj.socscimed.2006.04.013 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-05-03 N1 - Number of references - 47 N1 - Last updated - 2016-09-28 N1 - CODEN - SSCMAW N1 - SubjectsTermNotLitGenreText - Bangladesh; Slums; Adolescents; Quality of Life; Urbanization; Sex; Rural Communities DO - http://dx.doi.org/10.1016./j.socscimed.2006.04.013 ER - TY - JOUR T1 - Asylum nursing as a career in the United Kingdom, 1890-1910 AN - 57160232; 200708611 AB - Background. Nursing staff in lunatic asylums provided the day-to-day care and containment of patients and were the direct occupational ancestors of today's mental health nurses. Aim. This study explores (1) How was asylum nursing seen by asylum nurses themselves and by others, particularly other healthcare workers? (2) What were the demographic characteristics of those who became asylum nurses and what were their patterns of employment? Methods. Information regarding contemporary views of asylum nursing were gathered through searching a range of contemporary journals and other publications. Statistical information regarding patterns of employment was gathered from asylum records and census data. Findings. During the period from 1890 to 1910 the image of asylum nursing was poor. Allegations of brutality continued to effect its image, despite claims by asylum nurses and medical superintendents that such generalizations were unfair and that asylum nursing was at least as valuable as any other from of nursing. The middle class leadership of voluntary hospital general nursing was particularly critical. At the Three Counties Asylum in Southern England, the majority of asylum nurses came from unskilled or semi-skilled backgrounds. 43% were recruited locally; 43% of nursing staff left after less than a year, and less than a quarter remained after 3 years. Even those individuals thought to be suitable by prior experience, such as ex-servicemen, often did not stay long. Dismissals were common, especially amongst male staff (22%). The discipline was hard, hours long and the work often unpleasant. Conclusions. For asylum nurses conditions were poor, the work difficult and their public image negative. The reality was that people from working class backgrounds entered asylum nursing at a relatively young age, often travelling some distance to do so, and then many only stayed for short periods. However, some women were able to take advantage of the possibilities offered by asylum work to develop a career for themselves in the absence of other opportunities. Tables, 2. Adapted from the source document. JF - Journal of Advanced Nursing AU - Brimblecombe, Neil AD - Director of Mental Health Nursing, National Institute of Mental Health in England, London, UK Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 770 EP - 777 PB - Blackwell Publishing, Oxford UK VL - 55 IS - 6 SN - 0309-2402, 0309-2402 KW - historical analysis KW - mental health/psychiatry KW - nursing KW - Psychiatric hospitals KW - Nursing KW - Nurses KW - Historical perspectives KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57160232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Advanced+Nursing&rft.atitle=Asylum+nursing+as+a+career+in+the+United+Kingdom%2C+1890-1910&rft.au=Brimblecombe%2C+Neil&rft.aulast=Brimblecombe&rft.aufirst=Neil&rft.date=2006-09-01&rft.volume=55&rft.issue=6&rft.spage=770&rft.isbn=&rft.btitle=&rft.title=Journal+of+Advanced+Nursing&rft.issn=03092402&rft_id=info:doi/10.1111%2Fj.1365-2648.2006.03959.x LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-06-01 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Nursing; Nurses; Historical perspectives; Psychiatric hospitals DO - http://dx.doi.org/10.1111/j.1365-2648.2006.03959.x ER - TY - JOUR T1 - Sexual Initiation, Substance Use, and Sexual Behavior and Knowledge among Vocational Students in Northern Thailand AN - 57129235; 200708045 AB - CONTEXT: Thailand has undergone dramatic social changes in the last two decades, yet little is known about factors related to sexual initiation among adolescents. METHODS: A survey using the audio computer-assisted self-interviewing method was conducted to assess social & demographic characteristics, substance use, sexual behavior, & knowledge of HIV & STIs among 1,725 vocational school students aged 15-21 living in northern Thailand. Gender differences for these factors were evaluated using chi-square & Mann-Whitney U tests. Multivariate survival analysis using Cox proportional hazards models assessed associations between these variables & sexual initiation for each gender. RESULTS: Males initiated sexual intercourse at an earlier age than females (median ages of 17 & 18, respectively). At any given age, sexual initiation was associated with having a nonagricultural background & using alcohol or methamphetamine (adjusted rate ratios, 1.3-2.9). For males, initiation was also associated with having parents who did not live together, having a friend as a confidant, tobacco use, high perceived risk for HIV & high STI knowledge (1.3-1.7). For females, other factors associated with earlier initiation were younger age at interview, living away from family, lacking a family member as a confidant, high perceived risk for STIs & ever having smoked marijuana (1.3-2.4). CONCLUSIONS: Interventions to ameliorate the adverse consequences of early sexual initiation need to address social influences such as parents & peer groups. Programs should identify & target high-risk subgroups, such as those who are sexually experienced at an early age & those engaged in patterns of generalized risk-taking. Tables, Figures, References. Adapted from the source document. JF - International Family Planning Perspectives AU - Liu, Alice AU - Kilmarx, Peter AU - Jenkins, Richard A AU - Manopaiboon, Chomnad AU - Mock, Philip A AU - Jeeyapunt, Supaporn AU - Uthaivoravit, Wat AU - van Griensven, Frits AD - School Medicine, Stanford U, CA Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 126 EP - 135 PB - The Alan Guttmacher Institute, New York NY VL - 32 IS - 3 SN - 0190-3187, 0190-3187 KW - Sexual behaviour KW - Age of onset KW - Thailand KW - Gender differences KW - Substance abuse KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57129235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Family+Planning+Perspectives&rft.atitle=Sexual+Initiation%2C+Substance+Use%2C+and+Sexual+Behavior+and+Knowledge+among+Vocational+Students+in+Northern+Thailand&rft.au=Liu%2C+Alice%3BKilmarx%2C+Peter%3BJenkins%2C+Richard+A%3BManopaiboon%2C+Chomnad%3BMock%2C+Philip+A%3BJeeyapunt%2C+Supaporn%3BUthaivoravit%2C+Wat%3Bvan+Griensven%2C+Frits&rft.aulast=Liu&rft.aufirst=Alice&rft.date=2006-09-01&rft.volume=32&rft.issue=3&rft.spage=126&rft.isbn=&rft.btitle=&rft.title=International+Family+Planning+Perspectives&rft.issn=01903187&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - IFPPEB N1 - SubjectsTermNotLitGenreText - Thailand; Adolescents; Sexual behaviour; Substance abuse; Gender differences; Age of onset ER - TY - JOUR T1 - Behavioral Alterations in Reward System Function: The Role of Childhood Maltreatment and Psychopathology AN - 57057042; 200616368 AB - Objective: To examine in children the influence of maltreatment & associated psychiatric sequelae on behavioral responses to reward stimuli. Method: A computerized two-choice decision-making task involving probabilistic monetary gains was used to probe elemental processes of goal-directed actions. Using different risk contingencies, the authors examined decision-making, expectations of outcomes, & affective responses to rewards in 38 maltreated children & 21 demographically matched controls (8-14 years old). Results: Maltreated children selected risk options faster than controls; however, whereas controls responded more quickly as the chance of winning increased, maltreated children did not vary in response speed as a function of the likelihood of winning. When choosing between high- & low-risk options, maltreated children with depressive disorders more frequently selected safe over risky choices than did controls. No group differences emerged in self-report ratings of positive or negative reactions to winning or not winning, respectively. Conclusions: This initial experimental study of responses to reward lays the groundwork for subsequent research on neurodevelopmental aspects of reward processes in relationship to maltreatment & psychopathology. Clinical applications of these data may be relevant for developing treatment plans for maltreated children, particularly those with depression. Tables, Figures, References. Adapted from the source document. JF - Journal of the American Academy of Child & Adolescent Psychiatry AU - Guyer, Amanda E AU - Kaufman, Joan AU - Hodgdon, Hilary B AU - Masten, Carrie L AU - Jazbec, Sandra AU - Pine, Daniel S AU - Ernst, Monique AD - Mood & Anxiety Program, Emotional Development & Affective Neuroscience Branch, National Instit Mental Health amandaguyer@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 1059 EP - 1067 PB - Lippincott Williams & Wilkins, Hagerstown MD VL - 45 IS - 9 SN - 0890-8567, 0890-8567 KW - posttraumatic stress disorder, decision-making, risk-taking, motivation, depression KW - Decision making KW - Behavioural changes KW - Risk preferences KW - Rewards KW - Childhood maltreatment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57057042?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.atitle=Behavioral+Alterations+in+Reward+System+Function%3A+The+Role+of+Childhood+Maltreatment+and+Psychopathology&rft.au=Guyer%2C+Amanda+E%3BKaufman%2C+Joan%3BHodgdon%2C+Hilary+B%3BMasten%2C+Carrie+L%3BJazbec%2C+Sandra%3BPine%2C+Daniel+S%3BErnst%2C+Monique&rft.aulast=Guyer&rft.aufirst=Amanda&rft.date=2006-09-01&rft.volume=45&rft.issue=9&rft.spage=1059&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+American+Academy+of+Child+%26+Adolescent+Psychiatry&rft.issn=08908567&rft_id=info:doi/10.1097%2F01.chi.0000227882.50404.11 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Childhood maltreatment; Rewards; Risk preferences; Behavioural changes; Decision making DO - http://dx.doi.org/10.1097/01.chi.0000227882.50404.11 ER - TY - JOUR T1 - A Validity and Reliability Study of the Coping Self-Efficacy Scale AN - 57051655; 200616111 AB - Objectives: Investigate the psychometric characteristics of the coping self-efficacy (CSE) scale, a 26-item measure of one's confidence in performing coping behaviors when faced with life challenges. Design: Data came from two randomized clinical trials (N1=149, N2=199) evaluating a theory-based Coping Effectiveness Training (CET) intervention in reducing psychological distress & increasing positive mood in persons coping with chronic illness. Methods: The 348 participants were HIV-seropositive men with depressed mood who have sex with men. Participants were randomly assigned to intervention & comparison conditions & assessed pre- & post-intervention. Outcome variables included the CSE scale, ways of coping, & measures of social support & psychological distress & well-being. Results: Exploratory (EFA) & confirmatory factor analyses (CFA) revealed a 13-item reduced form of the CSE scale with three factors: Use problem-focused coping (6 items, a=.91), stop unpleasant emotions & thoughts (4 items, a=.91), & get support from friends & family (3 items, a=.80). Internal consistency & test-retest reliability are strong for all three factors. Concurrent validity analyses showed these factors assess self-efficacy for different types of coping. Predictive validity analyses showed that residualized change scores in using problem- & emotion-focused coping skills were predictive of reduced psychological distress & increased psychological well-being over time. Conclusions The CSE scale provides a measure of a person's perceived ability to cope effectively with life challenges, as well as a way to assess changes in CSE over time in intervention research. Tables, References. Adapted from the source document. JF - British Journal of Health Psychology AU - Chesney, Margaret A AU - Neilands, Torsten B AU - Chambers, Donald B AU - Taylor, Jonelle M AU - Folkman, Susan AD - National Center Complementary & Alternative Medicine, National Instits Health, Bethesda, MD chesneym@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 421 EP - 437 PB - British Psychological Society, Leicester, UK VL - 11 IS - 3 SN - 1359-107X, 1359-107X KW - Psychological wellbeing KW - Selfefficacy KW - Depression KW - Chronic sickness KW - Coping style KW - HIV KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57051655?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Health+Psychology&rft.atitle=A+Validity+and+Reliability+Study+of+the+Coping+Self-Efficacy+Scale&rft.au=Chesney%2C+Margaret+A%3BNeilands%2C+Torsten+B%3BChambers%2C+Donald+B%3BTaylor%2C+Jonelle+M%3BFolkman%2C+Susan&rft.aulast=Chesney&rft.aufirst=Margaret&rft.date=2006-09-01&rft.volume=11&rft.issue=3&rft.spage=421&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Health+Psychology&rft.issn=1359107X&rft_id=info:doi/10.1348%2F135910705X53155 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - BJHPFP N1 - SubjectsTermNotLitGenreText - Selfefficacy; Coping style; Chronic sickness; Depression; Psychological wellbeing; HIV DO - http://dx.doi.org/10.1348/135910705X53155 ER - TY - JOUR T1 - Social comparison processes in autobiographies of adult cancer survivors AN - 36577742; 3379910 AB - Cancer survivors often compare their situations to other survivors' situations. However, types of social comparison processes used and resulting outcomes are not clearly delineated. This study explores usage and consequences of three social comparison styles (downward, upward and parallel) of adult cancer survivors in free narratives, using content analysis of 30 autobiographical books by survivors ranging in age from 30-70 (M = 54, SD = 10.04); 43 percent prostate cancer, 17 percent breast cancer and 40 percent other cancers. Overall, cancer survivors used more parallel comparisons than directional comparisons, followed by upward comparisons. Each type of comparison was associated with different kinds of positive and negative consequences. Reprinted by permission of Sage Publications Ltd JF - Journal of health psychology AU - Bellizzi, Keith M AU - Blank, Thomas O AU - Oakes, Claudia E AD - National Cancer Institute, USA ; University of Connecticut Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 777 EP - 786 VL - 11 IS - 5 SN - 1359-1053, 1359-1053 KW - Sociology KW - Meaning KW - Attitudes KW - Psychology KW - Social perception KW - Survival KW - Discourse KW - Health KW - Narratives KW - Cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36577742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+health+psychology&rft.atitle=Social+comparison+processes+in+autobiographies+of+adult+cancer+survivors&rft.au=Bellizzi%2C+Keith+M%3BBlank%2C+Thomas+O%3BOakes%2C+Claudia+E&rft.aulast=Bellizzi&rft.aufirst=Keith&rft.date=2006-09-01&rft.volume=11&rft.issue=5&rft.spage=777&rft.isbn=&rft.btitle=&rft.title=Journal+of+health+psychology&rft.issn=13591053&rft_id=info:doi/10.1177%2F1359105306066637 LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 1939 3617 6220; 8470; 3607 2572; 11883 9382; 1378 10404; 10404; 12430; 5772; 7846 2688 2449 10404 DO - http://dx.doi.org/10.1177/1359105306066637 ER - TY - JOUR T1 - Diagnostic issues in substance use disorders: refining the research agenda AN - 36510216; 3314113 JF - Addiction AU - Saunders, John B AU - Schuckit, Marc A AU - Muthén, Bengt AU - Helzer, John E AU - Brink, Wim van den AU - Guth, Sarah E AU - Koob, George F AU - Room, Robin AU - Escobar, Javier I AU - Vega, William A AU - Hasin, Deborah AU - Hatzenbuehler, Mark L AU - Keyes, Katherine AU - Ogburn, Elizabeth AU - Nunes, Edward V AU - Rounsaville, Bruce J AU - Hesselbrock, Victor M AU - Hesselbrock, Michie N AU - Babor, Thomas F AU - Caetano, Raul AU - Crowley, Thomas J AU - Budney, Alan J AU - Hughes, John R AU - Potenza, Marc N AU - Petry, Nancy M AU - Cottler, Linda B AU - Grant, Bridget F AD - University of Queensland ; University of California ; University of Vermont ; University of Amsterdam ; Scripps Research Institute ; Melbourne University ; University of Medicine and Dentistry ; Columbia University ; New York Psychiatric Institute ; Yale University ; University of Connecticut ; University of Texas ; University of Colorado ; University of Arkansas ; Washington University ; National Institutes of Health Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1 EP - 173 VL - 101 IS - Supp. 1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Longitudinal studies KW - Typology KW - Psychology KW - Factor analysis KW - Health KW - Drug abuse KW - Classification KW - Research methods KW - Drug use KW - Cannabis KW - Addiction KW - Youth KW - Adolescents KW - Behavioural disorders KW - Neurology KW - Depression KW - Cross-cultural analysis KW - Medical research KW - Brain KW - Empirical research KW - Gambling KW - Epidemiology KW - Alcoholism KW - Mental health KW - Psychiatry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36510216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Diagnostic+issues+in+substance+use+disorders%3A+refining+the+research+agenda&rft.au=Saunders%2C+John+B%3BSchuckit%2C+Marc+A%3BMuth%C3%A9n%2C+Bengt%3BHelzer%2C+John+E%3BBrink%2C+Wim+van+den%3BGuth%2C+Sarah+E%3BKoob%2C+George+F%3BRoom%2C+Robin%3BEscobar%2C+Javier+I%3BVega%2C+William+A%3BHasin%2C+Deborah%3BHatzenbuehler%2C+Mark+L%3BKeyes%2C+Katherine%3BOgburn%2C+Elizabeth%3BNunes%2C+Edward+V%3BRounsaville%2C+Bruce+J%3BHesselbrock%2C+Victor+M%3BHesselbrock%2C+Michie+N%3BBabor%2C+Thomas+F%3BCaetano%2C+Raul%3BCrowley%2C+Thomas+J%3BBudney%2C+Alan+J%3BHughes%2C+John+R%3BPotenza%2C+Marc+N%3BPetry%2C+Nancy+M%3BCottler%2C+Linda+B%3BGrant%2C+Bridget+F&rft.aulast=Saunders&rft.aufirst=John&rft.date=2006-09-01&rft.volume=101&rft.issue=Supp.+1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - SuppNotes - Collection of 20 articles N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 561 6220; 3753 3755; 3742 1121 11776 3753 3755; 1942 3755; 913 561 6220; 7886 10902; 7947 5772 7954; 8635; 1750 1678; 10391; 10404; 3439 4196 7951 6220 7954; 5401 7336 3198; 1538 6071 1542 11325; 593; 13779 652 5676 646 6091; 4357 7894; 10919; 2360 2688 2449 10404; 13041 2688 2449 10404; 3058 971; 4722 12224 971; 7541 7537 971; 4200 10902 ER - TY - JOUR T1 - Characteristics of nosologically informative data sets that address key diagnostic issues facing the diagnostic and statistical manual of mental disorders, fifth edition (DSM-V) and international classification of diseases, eleventh edition (ICD-II) substance use disorders workgroups AN - 36504507; 3313905 AB - Aims Over the past two decades, many nosological issues have been addressed by the Diagnostic and Statistical Manual of Mental Disorders (DSM) and International Classification of Diseases (ICD) substance use disorders workgroups. Even with those efforts, there are key issues that have not been resolved and must be revisited, or addressed de novo, by the workgroups. These lingering points are broad, due to the array of substances classified under the diagnostic umbrella of substance use disorders. They include substantive issues ranging from dimensional approaches, similar criteria for each substance, cut-points and thresholds, distinct abuse and dependence classifications, new criteria and drugs, to less substantive ones, such as the adjectives used to describe the severity of the behaviors. Results This paper describes the characteristics of the data sets that will be needed to resolve the key nosological issues. Ten points are described: (1) data must be true to nomenclature under study: (2) flexible regarding rearrangements of scoring algorithms; (3-4) able to assess substances individually and retain former versions of the criteria; (5) not rely on shortened versions; (6) utilize samples that are generalizable; (7) make diagnoses with transparent algorithms; (8) combine mixed methods for corroborating data; (9) utilize assessments that collect reliable and valid diagnoses and criteria; and (10) stretch the limits by allowing for new discoveries. Conclusions This paper describes each of these and gives examples of the limitations and strengths of data for the purpose of defining a useful, unified concept of addictive behaviors. Reprinted by permission of Blackwell Publishing JF - Addiction AU - Cottler, Linda B AU - Grant, Bridget F AD - Washington University ; National Institutes of Health Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 161 EP - 169 VL - 101 IS - Supp. 1 SN - 0965-2140, 0965-2140 KW - Sociology KW - Classification KW - Medical research KW - Drug use KW - Mental health KW - Health KW - Diseases KW - Addiction UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36504507?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Addiction&rft.atitle=Characteristics+of+nosologically+informative+data+sets+that+address+key+diagnostic+issues+facing+the+diagnostic+and+statistical+manual+of+mental+disorders%2C+fifth+edition+%28DSM-V%29+and+international+classification+of+diseases%2C+eleventh+edition+%28ICD-II%29+substance+use+disorders+workgroups&rft.au=Cottler%2C+Linda+B%3BGrant%2C+Bridget+F&rft.aulast=Cottler&rft.aufirst=Linda&rft.date=2006-09-01&rft.volume=101&rft.issue=Supp.+1&rft.spage=161&rft.isbn=&rft.btitle=&rft.title=Addiction&rft.issn=09652140&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5772; 561 6220; 3753 3755; 7886 10902; 3617 6220; 2360 2688 2449 10404; 7947 5772 7954 ER - TY - JOUR T1 - Oligodendrocytes Are a Major Target of the Toxicity of Spongiogenic Murine Retroviruses AN - 21339395; 11671858 AB - The neurovirulent retroviruses FrCasE and Moloney MLV-ts1 cause noninflammatory spongiform neurodegeneration in mice, manifested clinically by progressive spasticity and paralysis. Neurons have been thought to be the primary target of toxicity of these viruses. However the neurons themselves appear not to be infected, and the possible indirect mechanisms driving the neuronal toxicity have remained enigmatic. Here we have re-examined the cells that are damaged by these viruses, using lieage-specific markers. Surprisingly, these cells expressed the basic helix-loop-helix transcription factor Olig2, placing them in the oligodendrocyte lineage. Olig2 super(+) cells were found to be infected, and many of these cells exhibited focal cytoplasmic vacuolation, suggesting that infection by spongiogenic retroviruses is directly toxic to these cells. As cytoplasmic vacuolation progressed, however, signs of viral protein expression appeared to wane, although residual viral RNA was detectable by in situ hybridization. Cells with the most advanced cytoplasmic effacement expressed the C/EBP-homologous protein (CHOP). This protein is up-regulated as a late event in a cellular response termed the integrated stress response. This observation may link the cellular pathology observed in the brain with cellular stress responses known to be induced by these viruses. The relevance of these observations to oligodendropathy in humans is discussed. JF - American Journal of Pathology AU - Clase, A C AU - Dimcheff, DE AU - Favara, C AU - Dorward, D AU - McAtee, F J AU - Parrie, LE AU - Ron, D AU - Portis, J L AD - Laboratory of Persistent Viral Diseases, Ricky Mountain Laboratories, National Institute of Allergy and Infectious, Diseases, National Institutes of Health, Hamilton, Montana, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1026 EP - 1038 VL - 169 IS - 3 SN - 0002-9440, 0002-9440 KW - Virology & AIDS Abstracts; Toxicology Abstracts; CSA Neurosciences Abstracts KW - spongiform encephalopathy KW - Oligodendrocytes KW - Neurovirulence KW - Brain KW - Stress KW - Toxicity KW - Olig2 protein KW - Infection KW - Helix-loop-helix proteins KW - Paralysis KW - Retrovirus KW - RNA KW - Transcription factors KW - Neurotoxicity KW - spasticity KW - X 24490:Other KW - N3 11027:Neurology & neuropathology KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21339395?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Oligodendrocytes+Are+a+Major+Target+of+the+Toxicity+of+Spongiogenic+Murine+Retroviruses&rft.au=Clase%2C+A+C%3BDimcheff%2C+DE%3BFavara%2C+C%3BDorward%2C+D%3BMcAtee%2C+F+J%3BParrie%2C+LE%3BRon%2C+D%3BPortis%2C+J+L&rft.aulast=Clase&rft.aufirst=A&rft.date=2006-09-01&rft.volume=169&rft.issue=3&rft.spage=1026&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2006.051357 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - spongiform encephalopathy; Oligodendrocytes; Brain; Neurovirulence; Stress; Toxicity; Infection; Olig2 protein; Helix-loop-helix proteins; Paralysis; RNA; Transcription factors; Neurotoxicity; spasticity; Retrovirus DO - http://dx.doi.org/10.2353/ajpath.2006.051357 ER - TY - JOUR T1 - Analysis of the Transcriptome of Group A Streptococcus in Mouse Soft Tissue Infection AN - 21333325; 11671850 AB - Molecular mechanisms mediating group A Streptococcus (GAS)-host interactions remain poorly understood but are crucial for diagnostic, therapeutic, and vaccine development. An optimized high-density microarray was used to analyze the transcriptome of GAS during experimental mouse soft tissue infection. The transcriptome of a wild-type serotype M1 GAS strain and an isogenic transcriptional regulator knockout mutant (covR) also were compared. Array datasets were verified by quantitative real-time reverse transcriptase-polymerase chain reaction and in situ immunohistochemistry. The results unambiguously demonstrate that coordinated expression of proven and putative GAS virulence factors is directed toward overwhelming innate host defenses leading to severe cellular damage. We also identified adaptive metabolic responses triggered by nutrient signals and hypoxic/acidic conditions in the host, likely facilitating pathogen persistence and proliferation in soft tissues. Key discoveries included that oxidative stress genes, virulence genes, genes related to amino acid and maltodextrin utilization, and several two-component transcriptional regulators were highly expressed in vivo. This study is the first global analysis of the GAS transcriptome during invasive infection. Coupled with parallel analysis of the covR mutant strain, novel insights have been made into the regulation of GAS virulence in vivo, resulting in new avenues for targeted therapeutic and vaccine research. JF - American Journal of Pathology AU - Graham, M R AU - Virtaneva, K AU - Porcella, S F AU - Gardner, D J AU - Long, R D AU - Welty, D M AU - Barry, W T AU - Johnson, CA AU - Parkins, L D AU - Wright, F A AU - Musser, J M AD - Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 927 EP - 942 VL - 169 IS - 3 SN - 0002-9440, 0002-9440 KW - Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Molecular modelling KW - Serotypes KW - Amino acids KW - virulence factors KW - Transcription KW - Nutrients KW - Pathogens KW - maltodextrin KW - Infection KW - DNA microarrays KW - Gene expression KW - Oxidative stress KW - Hypoxia KW - Polymerase chain reaction KW - Vaccines KW - Immunohistochemistry KW - Soft tissues KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21333325?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Pathology&rft.atitle=Analysis+of+the+Transcriptome+of+Group+A+Streptococcus+in+Mouse+Soft+Tissue+Infection&rft.au=Graham%2C+M+R%3BVirtaneva%2C+K%3BPorcella%2C+S+F%3BGardner%2C+D+J%3BLong%2C+R+D%3BWelty%2C+D+M%3BBarry%2C+W+T%3BJohnson%2C+CA%3BParkins%2C+L+D%3BWright%2C+F+A%3BMusser%2C+J+M&rft.aulast=Graham&rft.aufirst=M&rft.date=2006-09-01&rft.volume=169&rft.issue=3&rft.spage=927&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Pathology&rft.issn=00029440&rft_id=info:doi/10.2353%2Fajpath.2006.060112 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Amino acids; Serotypes; virulence factors; Transcription; Nutrients; maltodextrin; Pathogens; Infection; DNA microarrays; Gene expression; Oxidative stress; Hypoxia; Polymerase chain reaction; Vaccines; Soft tissues; Immunohistochemistry; Streptococcus DO - http://dx.doi.org/10.2353/ajpath.2006.060112 ER - TY - JOUR T1 - Development of a Cell-Based Reporter Assay for Screening of Inhibitors of Hypoxia-Inducible Factor 2-Induced Gene Expression AN - 21210887; 11617280 AB - Reporter cell lines have been developed for the identification of inhibitors of gene expression enhanced by hypoxia-inducible factor 2, which has been implicated as a transcription factor involved in the tumorigenesis of clear cell renal carcinoma. Stably transformed reporter clones of the human renal clear cell carcinoma cell line 786-O were generated by transfection or retroviral infection. Luciferase reporter expression in the vectors used was driven by either the natural human vascular endothelial growth factor (VEGF) promoter-enhancer or by the VEGF and the human endothelial nitric oxide synthase enhancers modulating minimal human cytomegalovirus promoter. Utility of the generated reporter cell lines was validated by introducing the von Hippel-Lindau protein complex and testing for reporter inducibility by hypoxia. The dynamic range in reporter activity under hypoxic stress was found to be at least 30- to 40-fold, with a signal-to-noise ratio of 60:1. Properties of the cell lines such as tolerance to up to 3% DMSO, signal stability with multiple in vitro passages, and utility in both 96- and 384-well plate formats indicated their suitability for use in a high-throughput screen. In addition, the potential use of these reporter lines in the evaluation of high-throughput screening hits in vivo in various mice models has been demonstrated. JF - Journal of Biomolecular Screening AU - Woldemichael, Girma M AU - Vasselli, James R AU - Gardella, Roberta S AU - Mckee, Tawnya C AU - Linehan, WMarston AU - McMahon, James B AD - National Cancer Institute, Molecular Targets Development Program, Center for Cancer Research, Frederick, Maryland Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 678 EP - 687 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 6 SN - 1087-0571, 1087-0571 KW - Genetics Abstracts; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - HIF-2 KW - cell-based assay KW - reporter assay KW - hypoxia response element KW - VHL disease KW - Vascular endothelial growth factor KW - Tumorigenesis KW - Animal models KW - Stress KW - VHL protein KW - Infection KW - Carcinoma KW - Nitric-oxide synthase KW - Gene expression KW - Expression vectors KW - Human cytomegalovirus KW - Promoters KW - Enhancers KW - Tumor cell lines KW - renal cell carcinoma KW - Transfection KW - Transcription factors KW - Hypoxia KW - high-throughput screening KW - Hypoxia-inducible factors KW - G 07730:Development & Cell Cycle KW - W 30935:Food Biotechnology KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21210887?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Development+of+a+Cell-Based+Reporter+Assay+for+Screening+of+Inhibitors+of+Hypoxia-Inducible+Factor+2-Induced+Gene+Expression&rft.au=Woldemichael%2C+Girma+M%3BVasselli%2C+James+R%3BGardella%2C+Roberta+S%3BMckee%2C+Tawnya+C%3BLinehan%2C+WMarston%3BMcMahon%2C+James+B&rft.aulast=Woldemichael&rft.aufirst=Girma&rft.date=2006-09-01&rft.volume=11&rft.issue=6&rft.spage=678&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057106289234 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Vascular endothelial growth factor; Tumorigenesis; Animal models; Stress; Infection; VHL protein; Carcinoma; Expression vectors; Gene expression; Nitric-oxide synthase; Enhancers; Promoters; Tumor cell lines; renal cell carcinoma; Transfection; Hypoxia; Transcription factors; high-throughput screening; Hypoxia-inducible factors; Human cytomegalovirus DO - http://dx.doi.org/10.1177/1087057106289234 ER - TY - JOUR T1 - Novel Approach to Analyzing RNA Aptamer-Protein Interactions: Toward Further Applications of Aptamers AN - 21208005; 11617276 AB - Surface plasmon-resonance analysis using a Biacore biosensor is a powerful tool for the detailed study of biomolecular interactions. The authors examined the methods of immobilizing proteins on the surface of NTA, SA, and CM5 sensor chips to study RNA aptamer-protein interactions. RNA aptamers and their deletion variants were loaded onto a protein-immobilized sensor chip, and their binding affinities were analyzed. Immobilizing the protein on a CM5 sensor chip via an anti-His-tag antibody was the only strategy that clearly detected the kinetic parameters of the interactions. NEO-III-14U, one of the deletion variants of the NS3 aptamer, had the highest binding affinity for the NS3 protein in this study (K sub(D) = 4 10 super(-8)). Moreover, the 29-amino-acid spacer fragment was essential for protein immobilization using this strategy. This novel method will be useful in comparing the affinity of various RNA aptamers and selecting the most suitable candidates for a given target, as well as facilitating the in vitro selection procedure itself. JF - Journal of Biomolecular Screening AU - Hwang, Joonsung AU - Nishikawa, Satoshi AD - Institute for Biological Resources and Functions, National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases, Developmental Skin Biology Unit, Bethesda, Maryland Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 599 EP - 605 PB - Sage Publications Ltd., 6 Bonhill St. London EC2A 4PU UK VL - 11 IS - 6 SN - 1087-0571, 1087-0571 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - RNA aptamers KW - immobilization KW - Biacore biosensor KW - surface plasmon-resonance analysis KW - SELEX technique KW - Aptamers KW - Biosensors KW - Antibodies KW - RNA KW - Kinetics KW - Spacer KW - Immobilization KW - W 30955:Biosensors KW - N 14810:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21208005?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biomolecular+Screening&rft.atitle=Novel+Approach+to+Analyzing+RNA+Aptamer-Protein+Interactions%3A+Toward+Further+Applications+of+Aptamers&rft.au=Hwang%2C+Joonsung%3BNishikawa%2C+Satoshi&rft.aulast=Hwang&rft.aufirst=Joonsung&rft.date=2006-09-01&rft.volume=11&rft.issue=6&rft.spage=599&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biomolecular+Screening&rft.issn=10870571&rft_id=info:doi/10.1177%2F1087057106288491 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-01-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Biosensors; Aptamers; Antibodies; RNA; Kinetics; Spacer; Immobilization DO - http://dx.doi.org/10.1177/1087057106288491 ER - TY - JOUR T1 - HIV/STD Stigmatization Fears as Health-Seeking Barriers in China AN - 211305939; 16374668 AB - Internationally, stigma prohibits effective HIV/STD identification, prevention, and care. Interviews with 106 persons in an urban center in Eastern China, some known to have engaged in stigmatized risk acts (sex workers, STD clinic patients) and some vulnerable for stigmatization fears to influence health-seeking behaviors (market employees, rural-to-urban migrants). Interviews focused on community norms, values, beliefs, and emotional and behavioral reactions to HIV/STD stigmatization related events. Attributions for infection were found to mark individual's failure to adhere to sexuality norms; define a condition warranting the avoidance of infected persons and dismissal by medical professionals; and promote anticipation of negative emotions (i.e., shame, fear, and embarrassment) and devalued social roles and status. Strategies reported to avoid stigmatization include avoiding HIV/STD knowledge; avoiding health care professionals, particularly in public settings; and conforming to community norms of shunning those suspected of risky behaviors. Results have direct implications for community marketing campaigns in China. JF - AIDS and Behavior AU - Lieber, Eli AU - Li, Li AU - Wu, Zunyou AU - Rotheram-Borus, Mary Jane AU - Guan, Jihui Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 463 EP - 71 CY - New York PB - Springer Science & Business Media VL - 10 IS - 5 SN - 10907165 KW - Psychology KW - Fear KW - Humans KW - Sexual Behavior KW - Adult KW - HIV Infections -- prevention & control KW - Health Knowledge, Attitudes, Practice KW - Interviews as Topic KW - Middle Aged KW - Sexually Transmitted Diseases -- prevention & control KW - Adolescent KW - Urban Population KW - China KW - Female KW - Male KW - Sexually Transmitted Diseases -- psychology KW - Stereotyping KW - Sexually Transmitted Diseases -- therapy KW - Patient Acceptance of Health Care KW - HIV Infections -- therapy KW - HIV Infections -- psychology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/211305939?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acriminaljusticeperiodicals&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+and+Behavior&rft.atitle=HIV%2FSTD+Stigmatization+Fears+as+Health-Seeking+Barriers+in+China&rft.au=Lieber%2C+Eli%3BLi%2C+Li%3BWu%2C+Zunyou%3BRotheram-Borus%2C+Mary+Jane%3BGuan%2C+Jihui&rft.aulast=Lieber&rft.aufirst=Eli&rft.date=2006-09-01&rft.volume=10&rft.issue=5&rft.spage=463&rft.isbn=&rft.btitle=&rft.title=AIDS+and+Behavior&rft.issn=10907165&rft_id=info:doi/10.1007%2Fs10461-005-9047-5 LA - English DB - ProQuest Central N1 - Copyright - Springer Science+Business Media, Inc. 2006 N1 - Last updated - 2014-09-25 N1 - CODEN - AIBEFC DO - http://dx.doi.org/10.1007/s10461-005-9047-5 ER - TY - JOUR T1 - OC139: A novel algorithm for fetal echocardiography using 4D ultrasound and tomographic imaging AN - 21065635; 8633379 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Espinoza, J AU - Kusanovic, J P AU - Goncalves, L F AU - Nien, J K AU - Hassan, S AU - Soto, E AU - Schoen, M L AU - Lee, W AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 399 EP - 400 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Echocardiography KW - Algorithms KW - imaging KW - Obstetrics KW - Ultrasound KW - Fetuses KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21065635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC139%3A+A+novel+algorithm+for+fetal+echocardiography+using+4D+ultrasound+and+tomographic+imaging&rft.au=Espinoza%2C+J%3BKusanovic%2C+J+P%3BGoncalves%2C+L+F%3BNien%2C+J+K%3BHassan%2C+S%3BSoto%2C+E%3BSchoen%2C+M+L%3BLee%2C+W%3BRomero%2C+R&rft.aulast=Espinoza&rft.aufirst=J&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=399&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.2999 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ultrasound; Obstetrics; Echocardiography; Algorithms; imaging; Fetuses; Gynecology DO - http://dx.doi.org/10.1002/uog.2999 ER - TY - JOUR T1 - Abnormal Intestinal Permeability in Primary Biliary Cirrhosis AN - 20982662; 7080570 AB - Antimitochondrial antibodies (AMAs) found in patients with primary biliary cirrhosis (PBC) cross-react with bacterial proteins and hence molecular mimicry has been proposed as a mechanism for AMA development. Alterations in gastrointestinal permeability would provide a potential route for increased exposure of gut flora to the immune system. In this study we aimed to compare the measured gastrointestinal permeability in patients with PBC to that in patients with liver disease (hepatitis C) and healthy control populations. Subjects drank a mixture of sucrose, lactulose, and mannitol dissolved in water. Eight-hour urinary excretion of the sugars was measured to assess intestinal permeability. Antiendomysial antibody testing was performed to exclude subclinical celiac disease. Eighty-six patients with PBC were evaluated and compared to 69 hepatitis C patients and 155 healthy controls. The mean urinary excretion of sucrose in the PBC patients (133.89 plus or minus 72.56 mg) was significantly higher than that in hepatitis C patients (101.07 plus or minus 63.35) or healthy controls (89.46 plus or minus 41.76) (P=0.0001), suggesting abnormal gastric or proximal small intestinal permeability. Sucrose excretion was not increased among patients with hepatitis C compared to healthy controls. The ratio of lactulose:mannitol excretion, reflecting small bowel permeability, was also elevated in the PBC group (0.017 plus or minus 0.012) compared to healthy controls (0.012 plus or minus 0.007) (P=0.0001) but was equal to that found among patients with hepatitis C (0.016 plus or minus 0.011) (P=NS). We conclude that the permeability of both the stomach and the small bowel is increased in patients with PBC, however, it is unclear if it is a cause, consequence, or manifestation of the disease. JF - Digestive Diseases and Sciences AU - Feld, Jordan J AU - Meddings, Jonathan AU - Heathcote, EJenny AD - NIDDK, NIH, 10 Center Drive, Room 9B16, MSC 1800, Bethesda, MD, 20892, USA, feldj@niddk.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1607 EP - 1613 PB - Springer New York, LLC, 233 Spring St New York NY 10013-1578 USA VL - 51 IS - 9 SN - 0163-2116, 0163-2116 KW - Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology KW - Sugar KW - Liver diseases KW - Immune system KW - Celiac disease KW - primary biliary cirrhosis KW - Permeability KW - Antibodies KW - Digestive tract KW - Mannitol KW - Sucrose KW - Intestine KW - Excretion KW - Hepatitis C KW - Stomach KW - Lactulose KW - J 02350:Immunology KW - V 22400:Human Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20982662?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Digestive+Diseases+and+Sciences&rft.atitle=Abnormal+Intestinal+Permeability+in+Primary+Biliary+Cirrhosis&rft.au=Feld%2C+Jordan+J%3BMeddings%2C+Jonathan%3BHeathcote%2C+EJenny&rft.aulast=Feld&rft.aufirst=Jordan&rft.date=2006-09-01&rft.volume=51&rft.issue=9&rft.spage=1607&rft.isbn=&rft.btitle=&rft.title=Digestive+Diseases+and+Sciences&rft.issn=01632116&rft_id=info:doi/10.1007%2Fs10620-006-9544-z LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Sugar; Liver diseases; Immune system; Celiac disease; primary biliary cirrhosis; Permeability; Antibodies; Digestive tract; Mannitol; Sucrose; Intestine; Excretion; Hepatitis C; Stomach; Lactulose DO - http://dx.doi.org/10.1007/s10620-006-9544-z ER - TY - JOUR T1 - Factors affecting the pharmacokinetic profile of MS-275, a novel histone deacetylase inhibitor, in patients with cancer AN - 20864216; 7162933 AB - Aims: To evaluate elimination pathways of the histone deacetylase inhibitor MS-275 in vitro and screen for relationships between demographic factors that may affect its pharmacokinetics in vivo. Patients and Methods: Substrate specificity of MS-275 for the liver-specific organic anion transporting polypeptides (OATPs) was assessed using Xenopus laevis oocytes, and in vitro metabolism was evaluated using human liver microsomes. In vivo pharmacokinetic data were obtained from 64 adult patients (36 male/28 female; median age, 57 years) receiving MS-275 orally (dose range, 2 to 12 mg/m super(2)). Results: Accumulation of [G- super(3)H]MS-275 by oocytes expressing OATP1B1 or OATP1B3 was not significantly different from water-injected controls (p = 0.82). Furthermore, no metabolites could be detected after incubation of MS-275 in human liver microsomes, suggesting that hepatic metabolism is a minor pathway of elimination. The mean ( plus or minus SD) apparent oral clearance of MS-275 was 38.5 plus or minus 18.7 L/h, with a coefficient of variation (%CV) of 48.7%. When clearance was adjusted for body-surface area (BSA), the inter-individual variability was similar (%CV = 50.1%). In addition, in a linear-regression analysis, except for adjusted ideal body weight (p = 0.02, |r| = 0.29), none of the studied measures (BSA, lean-body mass, ideal body weight, body-mass index, height, weight, age, and sex) was a significant covariate (p > 0.13; |r| < 0.11) for oral clearance. Conclusions: The current analysis has eliminated a number of candidate covariates from further consideration as important determinants of MS-275 absorption and disposition. Furthermore, MS-275 can be added to the list of cancer drugs where BSA-based dosing is not more accurate than fixed dosing. JF - Investigational New Drugs AU - Acharya, Milin R AU - Karp, Judith E AU - Sausville, Edward A AU - Hwang, Kyunghwa AU - Ryan, Qin AU - Gojo, Ivana AU - Venitz, Juergen AU - Figg, William D AU - Sparreboom, Alex AD - National Cancer Institute, Bethesda, MD, wdfigg@helix.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 367 EP - 375 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 24 IS - 5 SN - 0167-6997, 0167-6997 KW - Biotechnology and Bioengineering Abstracts KW - Histone deacetylase KW - Microsomes KW - Age KW - Data processing KW - Substrate specificity KW - Metabolites KW - Disposition KW - Cancer KW - Pharmacokinetics KW - organic anion transporting polypeptide KW - Demography KW - Xenopus laevis KW - Body weight KW - Liver KW - Oocytes KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20864216?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Investigational+New+Drugs&rft.atitle=Factors+affecting+the+pharmacokinetic+profile+of+MS-275%2C+a+novel+histone+deacetylase+inhibitor%2C+in+patients+with+cancer&rft.au=Acharya%2C+Milin+R%3BKarp%2C+Judith+E%3BSausville%2C+Edward+A%3BHwang%2C+Kyunghwa%3BRyan%2C+Qin%3BGojo%2C+Ivana%3BVenitz%2C+Juergen%3BFigg%2C+William+D%3BSparreboom%2C+Alex&rft.aulast=Acharya&rft.aufirst=Milin&rft.date=2006-09-01&rft.volume=24&rft.issue=5&rft.spage=367&rft.isbn=&rft.btitle=&rft.title=Investigational+New+Drugs&rft.issn=01676997&rft_id=info:doi/10.1007%2Fs10637-005-5707-6 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-09-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Histone deacetylase; Age; Microsomes; Data processing; Substrate specificity; Disposition; Metabolites; organic anion transporting polypeptide; Pharmacokinetics; Cancer; Demography; Body weight; Liver; Oocytes; Xenopus laevis DO - http://dx.doi.org/10.1007/s10637-005-5707-6 ER - TY - JOUR T1 - Partial field-of-view spiral phase-contrast imaging using complex difference processing AN - 20861347; 8368254 AB - Rapid flow imaging was achieved with a partial field of view (pFOV) spiral motion-encoded technique. The FOV and the acquisition time were reduced by a factor of 2 by undersampling k-space. The pFOV spiral k-space trajectory aliased signals from outside a circular ring whose radius was inversely proportional to the distance between adjacent spirals in k-space. In this study the FOV was adjusted so that all of the moving spins were located inside the inner half circle of the full FOV. Complex subtraction of two differentially flow-encoded images was used to remove the spurious phase sources and provide an accurate measurement of flow. The complex subtraction process also serves to eliminate aliasing artifacts that are generated by static tissue from outside the reduced FOV. Experiments in a flow phantom and volunteers showed that the flow estimates obtained by pFOV spiral motion encoding are in good agreement with the estimates reconstructed using complex difference processing. JF - Magnetic Resonance in Medicine AU - Nezafat, Reza AU - Thompson, Richard B AU - Derbyshire, J Andrew AU - McVeigh, Elliot R AD - Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA, nezafatr@nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 676 EP - 680 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 3 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - N.M.R. KW - imaging KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20861347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Partial+field-of-view+spiral+phase-contrast+imaging+using+complex+difference+processing&rft.au=Nezafat%2C+Reza%3BThompson%2C+Richard+B%3BDerbyshire%2C+J+Andrew%3BMcVeigh%2C+Elliot+R&rft.aulast=Nezafat&rft.aufirst=Reza&rft.date=2006-09-01&rft.volume=56&rft.issue=3&rft.spage=676&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20975 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - imaging; N.M.R. DO - http://dx.doi.org/10.1002/mrm.20975 ER - TY - JOUR T1 - Capacity Building for Integrated Coastal Management in Asia-Pacific: The Case for Case Studies AN - 20750097; 7566394 AB - Development of awareness and capacity is a central component to the delivery of ICM and spans from local communities to national-level politicians. Education and training activities associated with ICM must be extremely varied to match both the existing capacity and role that the stakeholders play within the process of ICM. Consequently, there cannot be considered any effective "generic" ICM training; training must be tailored to match the requirements of target groups. The transfer and uptake of good-practice thus becomes an important aspect of quality enhancement in ICM capacity development. Six case studies from the Asia-Pacific region are presented that show diverse and innovative examples of good practice. A comparative analysis of these case studies is carried out in terms of institutional level of impact. In addition a generic systems-based evaluation framework is used to determine the extent to which the training impacts upon ICM implementation indicators. It is concluded that the exchange, transfer, and translation to local conditions of appropriate good practice in ICM capacity development can be an important element in enhancing the impact of ICM programs on the coastal environments and societies. Furthermore, there appears to be a positive link between the involvement of national/state/regional stakeholders in capacity-building initiatives and impacting a wider variety of indicators of ICM delivery. JF - Coastal Management AU - Hills, J M AU - Alcock, D AU - Higham, T AU - Kirkman, H AU - Le Tissier, M AU - Pagdilao, C AU - Samonte, P C AU - Smith, T F AD - Ridley Building, University of Newcastle upon Tyne, Tyne & Wear, NEI 7RU, UK, j.hills@envision.uk.com Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 323 EP - 337 VL - 34 IS - 3 SN - 0892-0753, 0892-0753 KW - Sustainability Science Abstracts; Water Resources Abstracts; Oceanic Abstracts KW - target groups KW - Training KW - Case Studies KW - Indicators KW - local communities KW - Coastal zone management KW - Evaluation KW - case studies KW - Translations KW - Coastal zone KW - Education KW - Varieties KW - coastal zone management KW - Absorption KW - Capacity KW - stakeholders KW - O 6060:Coastal Zone Resources and Management KW - M3 1010:Issues in Sustainable Development KW - SW 7010:Education - extramural UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20750097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Assamodule&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Coastal+Management&rft.atitle=Capacity+Building+for+Integrated+Coastal+Management+in+Asia-Pacific%3A+The+Case+for+Case+Studies&rft.au=Hills%2C+J+M%3BAlcock%2C+D%3BHigham%2C+T%3BKirkman%2C+H%3BLe+Tissier%2C+M%3BPagdilao%2C+C%3BSamonte%2C+P+C%3BSmith%2C+T+F&rft.aulast=Hills&rft.aufirst=J&rft.date=2006-09-01&rft.volume=34&rft.issue=3&rft.spage=323&rft.isbn=&rft.btitle=&rft.title=Coastal+Management&rft.issn=08920753&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Education; Coastal zone; Translations; Coastal zone management; target groups; case studies; Training; coastal zone management; local communities; stakeholders; Evaluation; Case Studies; Varieties; Absorption; Indicators; Capacity ER - TY - JOUR T1 - Evolution of an intronic microsatellite polymorphism in Toll-like receptor 2 among primates AN - 20723274; 7119145 AB - Nonhuman primates express varying responses to Mycobacterium tuberculosis: New World monkeys appear to be resistant to tuberculosis (TB) while Old World monkeys seem to be particularly susceptible. The aim of this study was to elucidate the presence of the regulatory guanine-thymine (GT) repeat polymorphisms in intron 2 of Toll-like receptor 2 (TLR2) associated with the development of TB in humans and to determine any variations in these microsatellite polymorphisms in primates. We sequenced the region encompassing the regulatory GT repeat microsatellites in intron 2 of TLR2 in 12 different nonhuman primates using polymerase chain reaction amplification, TA cloning, and automatic sequencing. The nonhuman primates included for this study were as follows: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla gorilla), orangutan (Pongo pygmaeus), Celebes ape (Macaca nigra), rhesus monkey (Macaca mulatta), pigtail macaque (Macaca nemestrina), patas monkey (Erythrocebus patas), spider monkey (Ateles geoffroyi), Woolly monkey (Lagothrix lagotricha), tamarin (Saguinus labiatus), and ring-tailed lemur (Lemur catta). Nucleotide sequences encompassing the regulatory GT repeat region are similar across species and are completely conserved in great apes. However, Old World monkeys lack GT repeats altogether, while New World monkeys and ring-tailed lemurs have much more complex structures around the position of the repeats. In conclusion, the genetic structures encompassing the regulatory GT repeats in intron 2 of human TLR2 are similar among nonhuman primates. The sequence is most conserved in New World monkeys and less in Old World monkeys. JF - Immunogenetics AU - Yim, Jae-Joon AU - Adams, Amelia A AU - Kim, Ju Han AU - Holland, Steven M AD - National Institutes of Health, Building 10, CRC B3-4141, 10 Center Drive, MSC 1684, Bethesda, MD, 20892-1684, USA, smh@nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 740 EP - 745 PB - Springer-Verlag (Berlin), Heidelberger Platz 3 Berlin 14197 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 58 IS - 9 SN - 0093-7711, 0093-7711 KW - Bonobo KW - Chimpanzee KW - Orangutan KW - Pigtail Macaque KW - Rhesus macaque KW - Rhesus monkey KW - Ring-tailed lemur KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts; Immunology Abstracts KW - Macaca nemestrina KW - Ateles KW - TLR2 protein KW - Ateles geoffroyi KW - Immunogenetics KW - Lemur catta KW - Conserved sequence KW - Polymerase chain reaction KW - Macaca mulatta KW - Tuberculosis KW - Gorilla gorilla gorilla KW - Microsatellites KW - Macaca nigra KW - Primates KW - Pan troglodytes KW - Saguinus labiatus KW - Pan paniscus KW - Introns KW - Lagothrix lagotricha KW - Erythrocebus patas KW - Genetic structure KW - Pongo pygmaeus KW - Toll-like receptors KW - Evolution KW - Mycobacterium tuberculosis KW - G 07720:Immunogenetics KW - J 02350:Immunology KW - F 06950:Immunogenetics, MHC, HLA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20723274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunogenetics&rft.atitle=Evolution+of+an+intronic+microsatellite+polymorphism+in+Toll-like+receptor+2+among+primates&rft.au=Yim%2C+Jae-Joon%3BAdams%2C+Amelia+A%3BKim%2C+Ju+Han%3BHolland%2C+Steven+M&rft.aulast=Yim&rft.aufirst=Jae-Joon&rft.date=2006-09-01&rft.volume=58&rft.issue=9&rft.spage=740&rft.isbn=&rft.btitle=&rft.title=Immunogenetics&rft.issn=00937711&rft_id=info:doi/10.1007%2Fs00251-006-0141-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immunogenetics; TLR2 protein; Microsatellites; Introns; Polymerase chain reaction; Conserved sequence; Tuberculosis; Genetic structure; Evolution; Toll-like receptors; Gorilla gorilla gorilla; Ateles; Macaca nemestrina; Primates; Macaca nigra; Pan troglodytes; Ateles geoffroyi; Saguinus labiatus; Pan paniscus; Lemur catta; Macaca mulatta; Erythrocebus patas; Lagothrix lagotricha; Pongo pygmaeus; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1007/s00251-006-0141-2 ER - TY - JOUR T1 - Relation of body mass index to cancer risk in 362,552 Swedish men AN - 20721516; 7239298 AB - Background: Obesity has been linked with increased risk for cancers of the colon, kidney, breast, endometrium and gallbladder. For other cancer sites, the relationship with obesity is less well quantified, and the effect of weight change on cancer risk is unclear. Methods: We examined the health records of 362,552 Swedish men who underwent at least one physical examination from 1971 to 1992, and were followed until death or the end of 1999. Incident cancer cases were identified by linkage to the Swedish cancer registry. Poisson regression models were used to estimate relative risks of cancer for both body-mass index (BMI) at baseline exam and, in a subgroup of 107,815 men, change in BMI after six years of follow-up, adjusting for age and smoking status. Results: Compared to men of normal weight, obese men had a significantly increased risk of all cancers combined (RR = 1.1; 95% CI = 1.0-1.2). The risks were most pronounced for esophageal adenocarcinoma (RR = 2.7; 95% CI = 1.3-5.6), renal cell carcinoma (RR = 1.8; 95% CI = 1.4-2.4), malignant melanoma (RR = 1.4; 95% CI = 1.1-1.7), and cancers of the colon (RR = 1.7; 95% CI = 1.5-2.0), rectum (RR = 1.4; 95% CI = 1.1-1.7), and liver (RR = 3.6; 95% CI = 2.6-5.0). Risk of esophageal squamous cell carcinoma was elevated for underweight men whose BMI was less than 18.5 (RR = 3.1; 95% CI = 1.1-8.3). An excess risk for cancers of the pancreas and connective tissue was observed only among nonsmokers. Compared to men whose weight remained stable, men with more than a 15% increase in BMI after six years of follow-up had an elevated risk of pancreas and renal cell cancers. Conclusions: Obesity and weight gain increase the risk for several forms of cancer in men, and underscore the need for further study into carcinogenic mechanisms and preventive interventions. JF - Cancer Causes & Control AU - Samanic, Claudine AU - Chow, Wong-Ho AU - Gridley, Gloria AU - Jarvholm, Bengt AU - Fraumeni, Joseph F AD - National Cancer Institute, National Institutes of Health, 6120 Executive Blvd., Room 8115, Bethesda, MD, 20892, USA, samanicc@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 901 EP - 909 PB - Springer-Verlag (Heidelberg), Tiergartenstrasse 17 Heidelberg 69121 Germany, [mailto:subscriptions@springer.de], [URL:http://www.springer.de/] VL - 17 IS - 7 SN - 0957-5243, 0957-5243 KW - Risk Abstracts KW - Mortality KW - Age KW - obesity KW - males KW - melanoma KW - Cancer KW - Smoking KW - body mass KW - Carcinogenicity KW - intervention KW - Liver KW - Kidney KW - body weight KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20721516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Causes+%26+Control&rft.atitle=Relation+of+body+mass+index+to+cancer+risk+in+362%2C552+Swedish+men&rft.au=Samanic%2C+Claudine%3BChow%2C+Wong-Ho%3BGridley%2C+Gloria%3BJarvholm%2C+Bengt%3BFraumeni%2C+Joseph+F&rft.aulast=Samanic&rft.aufirst=Claudine&rft.date=2006-09-01&rft.volume=17&rft.issue=7&rft.spage=901&rft.isbn=&rft.btitle=&rft.title=Cancer+Causes+%26+Control&rft.issn=09575243&rft_id=info:doi/10.1007%2Fs10552-006-0023-9 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-10-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Mortality; Age; obesity; males; melanoma; Cancer; Smoking; Carcinogenicity; body mass; intervention; Kidney; Liver; body weight DO - http://dx.doi.org/10.1007/s10552-006-0023-9 ER - TY - JOUR T1 - Identifying Risk for Obesity in Early Childhood AN - 20720191; 7064422 AB - OBJECTIVES. Our aim with this study was to assist clinicians by estimating the predictive value of earlier levels of BMI status on later risk of overweight and obesity during the middle childhood and early adolescent years. METHODS. We present growth data from the National Institute of Child Health and Human Development Study of Early Child Care and Youth Development, a longitudinal sample of 1042 healthy US children in 10 locations. Born in 1991, their growth reflects the secular trend of increasing overweight/obesity in the population. Height and weight of participating children in the study were measured at 7 time points. We examined odds ratios for overweight and obesity at age 12 years comparing the frequency with which children did versus did not reach specific BMI percentiles in the preschool- and elementary-age periods. To explore the question of whether and when earlier BMI was predictive of weight status at age 12 years, we used logistic regression to obtain the predicted probabilities of being overweight or obese (BMI greater than or equal to 85%) at 12 years old on the basis of earlier BMI. RESULTS. Persistence of obesity is apparent for both the preschool and elementary school period. Children who were ever overweight (>85th percentile), that is, greater than or equal to 1 time at ages 24, 36, or 54 months during the preschool period were >5 times as likely to be overweight at age 12 years than those who were below the 85th percentile for BMI at all 3 of the preschool ages. During the elementary school period, ages 7, 9, and 11 years, the more times a child was overweight, the greater the odds of being overweight at age 12 years relative to a child who was never overweight. Sixty percent of children who were overweight at any time during the preschool period and 80% of children who were overweight at any time during the elementary period were overweight at age 12 years. Follow-up calculations showed that 2 in 5 children whose BMIs were greater than or equal to 50th percentile by age 3 years were overweight at age 12 years. No children who were 6 times more likely to be overweight at age 12 years than those 85th percentile, as well as with BMIs in the high reference range are more likely than children whose BMI is <50th percentile to continue to gain weight and reach overweight status by adolescence. Pediatricians can be confident in counseling parents to begin to address the at-risk child's eating and activity patterns rather than delaying in hopes that overweight and the patterns that support it will resolve themselves in due course. Identifying children at risk for adolescent obesity provides physicians with an opportunity for earlier intervention with the goal of limiting the progression of abnormal weight gain that results in the development of obesity-related morbidity. JF - Pediatrics AU - Nader, Philip R AU - O'Brien, Marion AU - Houts, Renate AU - Bradley, Robert AU - Belsky, Jay AU - Crosnoe, Robert AU - Friedman, Sarah AU - Mei, Zuguo AU - Susman, Elizabeth J AD - Division of Community Pediatrics, University of California, San Diego, California. Department of Human Development and Family Studies, University of North Carolina, Greensboro, North Carolina. Statistics and Epidemiology, Research Triangle Institute, Research Triangle Park, North Carolina. Center for Applied Studies in Education, University of Arkansas, Little Rock, Arkansas. Institute for Study of Children, Families and Social Issues, Birkbeck University of London, London, United Kingdom. Department of Sociology and Population Research Center, University of Texas, Austin, Texas. National Institute of Child Health and Human Development, Bethesda, Maryland. Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, Georgia. Department of Biobehavioral Health, Pennsylvania State University, University Park, Pennsylvania Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - e594 EP - e601 PB - American Academy of Pediatrics, 141 Northwest Point Blvd. Elk Grove Village IL 60007-1098 USA, [mailto:journals@aap.org], [URL:http://www.aap.org] VL - 118 IS - 3 SN - 0031-4005, 0031-4005 KW - Physical Education Index; Risk Abstracts KW - Measurement KW - Age KW - Eating disorders KW - obesity KW - Health KW - Morbidity KW - Elementary schools KW - schools KW - Weight KW - intervention KW - Physicians KW - body weight KW - Adolescents KW - Youth KW - Obesity KW - Pediatrics KW - Adolescence KW - Diet (weight control) KW - Height KW - Counseling KW - Children KW - Trends KW - R2 23060:Medical and environmental health KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20720191?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatrics&rft.atitle=Identifying+Risk+for+Obesity+in+Early+Childhood&rft.au=Nader%2C+Philip+R%3BO%27Brien%2C+Marion%3BHouts%2C+Renate%3BBradley%2C+Robert%3BBelsky%2C+Jay%3BCrosnoe%2C+Robert%3BFriedman%2C+Sarah%3BMei%2C+Zuguo%3BSusman%2C+Elizabeth+J&rft.aulast=Nader&rft.aufirst=Philip&rft.date=2006-09-01&rft.volume=118&rft.issue=3&rft.spage=e594&rft.isbn=&rft.btitle=&rft.title=Pediatrics&rft.issn=00314005&rft_id=info:doi/ LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-06-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Measurement; Age; Pediatrics; Eating disorders; Adolescence; Diet (weight control); Height; Health; Children; Counseling; Elementary schools; Weight; Physicians; Trends; Youth; schools; intervention; obesity; body weight; Morbidity; Adolescents ER - TY - JOUR T1 - Effect of Fluoridated Public Water Supplies on Dental Caries Prevalence AN - 20493202; 7791463 AB - As early as 1942, it had been adequately demonstrated that the use of fluoride-bearing drinking waters produces a marked reduction in the incidence of dental caries. It was also known by that time that this beneficial effect occurs in populations using water supplies containing fluoride from natural sources in concentrations below the level established as the threshold for mottled enamel or endemic fluorosis. JF - Bulletin of The World Health Organization AU - Arnold, FA Jr AU - Dean, H T AU - Jay, P AU - Knutson, J W AD - National Institute of Dental Research, National Institutes of Health, Public Health Service Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 761 VL - 84 IS - 9 SN - 0042-9686, 0042-9686 KW - Aqualine Abstracts KW - Drinking Water KW - Water Supply KW - Public Waters KW - Fluorides KW - AQ 00004:Water Treatment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20493202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aaqualine&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bulletin+of+The+World+Health+Organization&rft.atitle=Effect+of+Fluoridated+Public+Water+Supplies+on+Dental+Caries+Prevalence&rft.au=Arnold%2C+FA+Jr%3BDean%2C+H+T%3BJay%2C+P%3BKnutson%2C+J+W&rft.aulast=Arnold&rft.aufirst=FA&rft.date=2006-09-01&rft.volume=84&rft.issue=9&rft.spage=761&rft.isbn=&rft.btitle=&rft.title=Bulletin+of+The+World+Health+Organization&rft.issn=00429686&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-01-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Drinking Water; Water Supply; Public Waters; Fluorides ER - TY - JOUR T1 - Hispanic drug abuse research: Challenges and opportunities AN - 20401696; 7763615 AB - Abstract not available. JF - Drug and Alcohol Dependence AU - Volkow, Nora D AD - National Institute on Drug Abuse, 6001 Executive Boulevard, Room 5274, MSC 9581, Bethesda, MD 20892-9589, United States, nvolkow@nida.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - S4 EP - S7 PB - Elsevier Science, P.O. Box 85 Limerick Ireland VL - 84 SN - 0376-8716, 0376-8716 KW - Toxicology Abstracts KW - Drug dependence KW - Drug abuse KW - X 24380:Social Poisons & Drug Abuse UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20401696?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+and+Alcohol+Dependence&rft.atitle=Hispanic+drug+abuse+research%3A+Challenges+and+opportunities&rft.au=Volkow%2C+Nora+D&rft.aulast=Volkow&rft.aufirst=Nora&rft.date=2006-09-01&rft.volume=84&rft.issue=&rft.spage=S4&rft.isbn=&rft.btitle=&rft.title=Drug+and+Alcohol+Dependence&rft.issn=03768716&rft_id=info:doi/10.1016%2Fj.drugalcdep.2006.05.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-12-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Drug dependence; Drug abuse DO - http://dx.doi.org/10.1016/j.drugalcdep.2006.05.002 ER - TY - JOUR T1 - Human embryonic stem cells have a unique epigenetic signature AN - 20227799; 7060056 AB - Human embryonic stem (hES) cells originate during an embryonic period of active epigenetic remodeling. DNA methylation patterns are likely to be critical for their self-renewal and pluripotence. We compared the DNA methylation status of 1536 CpG sites (from 371 genes) in 14 independently isolated hES cell lines with five other cell types: 24 cancer cell lines, four adult stem cell populations, four lymphoblastoid cell lines, five normal human tissues, and an embryonal carcinoma cell line. We found that the DNA methylation profile clearly distinguished the hES cells from all of the other cell types. A subset of 49 CpG sites from 40 genes contributed most to the differences among cell types. Another set of 25 sites from 23 genes distinguished hES cells from normal differentiated cells and can be used as biomarkers to monitor differentiation. Our results indicate that hES cells have a unique epigenetic signature that may contribute to their developmental potential. JF - Genome Research AU - Bibikova, Marina AU - Chudin, Eugene AU - Wu, Bonnie AU - Zhou, Lixin AU - Garcia, Eliza Wickham AU - Liu, Ying AU - Shin, Soojung AU - Plaia, Todd W AU - Auerbach, Jonathan M AU - Arking, Dan E AU - Gonzalez, Rodolfo AU - Crook, Jeremy AU - Davidson, Bruce AU - Schulz, Thomas C AU - Robins, Allan AU - Khanna, Aparna AU - Sartipy, Peter AU - Hyllner, Johan AU - Vanguri, Padmavathy AU - Savant-Bhonsale, Smita AU - Smith, Alan K AU - Chakravarti, Aravinda AU - Maitra, Anirban AU - Rao, Mahendra AU - Barker, David L AU - Loring, Jeanne F AU - Fan, Jian-Bing AD - Illumina, Inc., San Diego, California 92121, USA. Laboratory of Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. Stem Cell Center, American Type Culture Collection, Manassas, Virginia 20108, USA. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. Stem Cell Center, Burnham Institute for Medical Research, La Jolla, California 92037, USA. ES Cell International, The Gemini 117610, Singapore. BresaGen, Inc., Athens, Georgia 30605, USA. Reliance Life Sciences Pvt. Ltd., Mumbai 400 701, India. Cellartis AB, 413 46 Goteborg, Sweden. Theradigm, Inc., Baltimore, Maryland 21227, USA. Cognate Therapeutics, Inc., Baltimore, Maryland 21227, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1075 EP - 1083 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 16 IS - 9 SN - 1088-9051, 1088-9051 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Genomes KW - Differentiation KW - Stem cells KW - Tumor cell lines KW - Embryo cells KW - Lymphoblastoid cell lines KW - epigenetics KW - DNA methylation KW - CpG islands KW - biomarkers KW - W 30940:Products KW - N 14820:DNA Metabolism & Structure KW - G 07250:Developmental genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20227799?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Genome+Research&rft.atitle=Human+embryonic+stem+cells+have+a+unique+epigenetic+signature&rft.au=Bibikova%2C+Marina%3BChudin%2C+Eugene%3BWu%2C+Bonnie%3BZhou%2C+Lixin%3BGarcia%2C+Eliza+Wickham%3BLiu%2C+Ying%3BShin%2C+Soojung%3BPlaia%2C+Todd+W%3BAuerbach%2C+Jonathan+M%3BArking%2C+Dan+E%3BGonzalez%2C+Rodolfo%3BCrook%2C+Jeremy%3BDavidson%2C+Bruce%3BSchulz%2C+Thomas+C%3BRobins%2C+Allan%3BKhanna%2C+Aparna%3BSartipy%2C+Peter%3BHyllner%2C+Johan%3BVanguri%2C+Padmavathy%3BSavant-Bhonsale%2C+Smita%3BSmith%2C+Alan+K%3BChakravarti%2C+Aravinda%3BMaitra%2C+Anirban%3BRao%2C+Mahendra%3BBarker%2C+David+L%3BLoring%2C+Jeanne+F%3BFan%2C+Jian-Bing&rft.aulast=Bibikova&rft.aufirst=Marina&rft.date=2006-09-01&rft.volume=16&rft.issue=9&rft.spage=1075&rft.isbn=&rft.btitle=&rft.title=Genome+Research&rft.issn=10889051&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Differentiation; Tumor cell lines; Stem cells; Lymphoblastoid cell lines; Embryo cells; epigenetics; DNA methylation; CpG islands; biomarkers ER - TY - JOUR T1 - Signals from Embryonic Fibroblasts Induce Adult Intestinal Epithelial Cells to Form Nestin-Positive Cells with Proliferation and Multilineage Differentiation Capacity In Vitro AN - 19977201; 7065598 AB - The intestinal epithelium has one of the greatest regenerative capacities in the body; however, neither stem nor progenitor cells have been successfully cultivated from the intestine. In this study, we applied an "artificial niche" of mouse embryonic fibroblasts to derive multipotent cells from the intestinal epithelium. Cocultivation of adult mouse and human intestinal epithelium with fibroblast feeder cells led to the generation of a novel type of nestin-positive cells (intestinal epithelium-derived nestin-positive cells [INPs]). Transcriptome analyses demonstrated that mouse embryonic fibroblasts expressed relatively high levels of Wnt/bone morphogenetic protein (BMP) transcripts, and the formation of INPs was specifically associated with an increase in Lef1, Wnt4, Wnt5a, and Wnt/BMP-responsive factors, but a decrease of BMP4 transcript abundance. In vitro, INPs showed a high but finite proliferative capacity and readily differentiated into cells expressing neural, pancreatic, and hepatic transcripts and proteins; however, these derivatives did not show functional properties. In vivo, INPs failed to form chimeras following injection into mouse blastocysts but integrated into hippocampal brain slice cultures in situ. We conclude that the use of embryonic fibroblasts seems to reprogram adult intestinal epithelial cells by modulation of Wnt/BMP signaling to a cell type with a more primitive embryonic-like stage of development that has a high degree of flexibility and plasticity. JF - Stem Cells AU - Wiese, Cornelia AU - Rolletschek, Alexandra AU - Kania, Gabriela AU - Navarrete-Santos, Anne AU - Anisimov, Sergey V AU - Steinfarz, Barbara AU - Tarasov, Kirill V AU - Brugh, Sheryl A AU - Zahanich, Ihor AU - Rueschenschmidt, Christiane AU - Beck, Heinz AU - Blyszczuk, Przemyslaw AU - Czyz, Jaroslaw AU - Heubach, Juergen F AU - Ravens, Ursula AU - Horstmann, Olaf AU - St-Onge, Luc AU - Braun, Thomas AU - Bruestle, Oliver AU - Boheler, Kenneth R AU - Wobus, Anna M AD - In Vitro Differentiation Group, Institute of Plant Genetics and Crop Plant Research, Gatersleben, Germany. Institute of Anatomy and Cell Biology, University of Halle-Wittenberg, Halle, Germany. Gerontology Research Center, National Institute on Aging, NIH, Baltimore, Maryland, USA. Institute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn and Hertie Foundation, Bonn, Germany. Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany. Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany. Surgery University Clinics, Medical Faculty, University of Goettingen, Goettingen, Germany. DeveloGen AG, Goettingen, Germany. Department of Epileptology, University of Bonn, Bonn, Germany Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 2085 EP - 2097 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 9 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - Epithelial cells KW - Wnt protein KW - Hippocampus KW - Pancreas KW - Developmental stages KW - Cell culture KW - Gene expression KW - Differentiation KW - Chimeras KW - blastocysts KW - Stem cells KW - Bone morphogenetic proteins KW - Embryogenesis KW - Embryo fibroblasts KW - Intestine KW - Liver KW - Epithelium KW - Brain slice preparation KW - Cell proliferation KW - Bone morphogenetic protein 4 KW - Signal transduction KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19977201?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Signals+from+Embryonic+Fibroblasts+Induce+Adult+Intestinal+Epithelial+Cells+to+Form+Nestin-Positive+Cells+with+Proliferation+and+Multilineage+Differentiation+Capacity+In+Vitro&rft.au=Wiese%2C+Cornelia%3BRolletschek%2C+Alexandra%3BKania%2C+Gabriela%3BNavarrete-Santos%2C+Anne%3BAnisimov%2C+Sergey+V%3BSteinfarz%2C+Barbara%3BTarasov%2C+Kirill+V%3BBrugh%2C+Sheryl+A%3BZahanich%2C+Ihor%3BRueschenschmidt%2C+Christiane%3BBeck%2C+Heinz%3BBlyszczuk%2C+Przemyslaw%3BCzyz%2C+Jaroslaw%3BHeubach%2C+Juergen+F%3BRavens%2C+Ursula%3BHorstmann%2C+Olaf%3BSt-Onge%2C+Luc%3BBraun%2C+Thomas%3BBruestle%2C+Oliver%3BBoheler%2C+Kenneth+R%3BWobus%2C+Anna+M&rft.aulast=Wiese&rft.aufirst=Cornelia&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=2085&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Epithelial cells; Wnt protein; Hippocampus; Pancreas; Developmental stages; Cell culture; Gene expression; Chimeras; Differentiation; Embryogenesis; Bone morphogenetic proteins; Stem cells; blastocysts; Embryo fibroblasts; Liver; Intestine; Epithelium; Brain slice preparation; Cell proliferation; Bone morphogenetic protein 4; Signal transduction ER - TY - JOUR T1 - The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent AN - 19850205; 7082379 AB - Conformationally locked (North)-methanocarbathymidine (N-MCT) and (South)-methanocarbathymidine (S-MCT) have been used to investigate the conformational preferences of kinases and polymerases. The herpes kinases show a distinct bias for S-MCT, while DNA polymerases almost exclusively incorporate the North 5'-triphosphate (N-MCT-TP). Only N-MCT demonstrated potent antiviral activity against herpes simplex viruses (HSV-1 and 2) and Kaposi's sarcoma-associated herpesvirus (KSHV). The activity of N-MCT depends on its metabolic transformation to N-MCT-TP by the herpes kinases (HSV-tk or KSHV-tk), which catalyze the mono and diphosphorylation steps; cellular kinases generate the triphosphate. N-MCT at a dose of 5.6mg/kg was totally protective for mice inoculated intranasally with HSV-1. Tumor cells that are not responsive to antiviral therapy became sensitive to N-MCT if the cells expressed HSV-tk. N-MCT given twice daily (100mg/kg) for 7 days completely inhibited the growth of MC38 tumors derived from cells that express HSV-tk in mice while exhibiting no effect on tumors derived from non-transduced cells. After i.p. administration, N-MCT was rapidly absorbed and distributed in all organs examined with slow penetration into brain and testes. N-MCT-TP was also a potent inhibitor of HIV replication in human osteosarcoma (HOS) cells expressing HSV-tk. JF - Antiviral Research AU - Marquez, V E AU - Hughes, SH AU - Sei, S AU - Agbaria, R AD - National Cancer Institute at Frederick, P.O. Box B, Building 539, Frederick, MD 21702, USA, marquezv@dc37a.nci.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 268 EP - 275 PB - Elsevier B.V. VL - 71 IS - 2-3 SN - 0166-3542, 0166-3542 KW - HIV KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts KW - Testes KW - Transformation KW - Human herpesvirus 8 KW - Replication KW - Herpes simplex virus 1 KW - Kaposi's sarcoma-associated herpesvirus KW - Brain KW - Osteosarcoma KW - Tumors KW - Antiviral activity KW - Tumor cells KW - Herpes simplex KW - Antiviral agents KW - Human immunodeficiency virus KW - DNA-directed DNA polymerase KW - nucleosides KW - A 01340:Antibiotics & Antimicrobials KW - V 22360:AIDS and HIV KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19850205?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antiviral+Research&rft.atitle=The+history+of+N-methanocarbathymidine%3A+The+investigation+of+a+conformational+concept+leads+to+the+discovery+of+a+potent+and+selective+nucleoside+antiviral+agent&rft.au=Marquez%2C+V+E%3BHughes%2C+SH%3BSei%2C+S%3BAgbaria%2C+R&rft.aulast=Marquez&rft.aufirst=V&rft.date=2006-09-01&rft.volume=71&rft.issue=2-3&rft.spage=268&rft.isbn=&rft.btitle=&rft.title=Antiviral+Research&rft.issn=01663542&rft_id=info:doi/10.1016%2Fj.antiviral.2006.04.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transformation; Testes; Antiviral agents; Replication; DNA-directed DNA polymerase; nucleosides; Brain; Osteosarcoma; Tumors; Antiviral activity; Herpes simplex; Tumor cells; Human immunodeficiency virus; Human herpesvirus 8; Kaposi's sarcoma-associated herpesvirus; Herpes simplex virus 1 DO - http://dx.doi.org/10.1016/j.antiviral.2006.04.012 ER - TY - JOUR T1 - Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin AN - 19845258; 7124909 AB - Islet neogenesis associated protein (INGAP) is a protein factor that can stimulate new islet mass from adult pancreatic progenitor cells. In models of islet neogenesis, INGAP expression is elevated in pancreatic acinar cells. Using a transgenic model to drive a sustained expression of INGAP in pancreatic acinar cells, we have identified a protection to chemical-induced hyperglycemia. A sustained expression of INGAP during development did not perturb islet development or basal blood glucose homeostasis, although {szligbeta}-cell mass and pancreatic insulin content were significantly increased in the INGAP transgenic mice. When challenged with a diabetogenic dose of streptozotocin (STZ), mice carrying the INGAP transgene did not become hyperglycemic. In contrast, wild-type mice became and remained hyperglycemic, blood glucose > 550 mg/dl. The serum insulin levels and islet morphology were preserved in the transgenic mice after STZ treatment. These data suggest that the sustained expression of INGAP in the acinar pancreas confers resistance to a diabetogenic insult. The INGAP transgenic mouse provides a new model to uncover factors that are protective to diabetes onset and biomarkers to track {szligbeta}-cell pathology. JF - Journal of Endocrinology AU - Taylor-Fishwick, David A AU - Bowman, Angela AU - Hamblet, Natasha AU - Bernard, Paul AU - Harlan, David M AU - Vinik, Aaron I AD - Departments of Internal Medicine, Microbiology and Molecular Cell Biology, Anatomy and Pathology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA NIDDK, NIH, DHHS, Mark O Hatfield Clinical Research Center, Room 5-5940, Bethesda, Maryland 20892, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 729 EP - 737 PB - Portland Press Ltd., 59 Portland Place London W1N 3AJ UK, [mailto:sales@portlandpress.co.uk] VL - 190 IS - 3 SN - 0022-0795, 0022-0795 KW - Biotechnology and Bioengineering Abstracts KW - Data processing KW - Pancreas KW - Glucose KW - Islets of Langerhans KW - Homeostasis KW - Streptozocin KW - Transgenic mice KW - biomarkers KW - Insulin KW - Acinar cells KW - Diabetes mellitus KW - Blood KW - Stem cells KW - Hyperglycemia KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19845258?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Endocrinology&rft.atitle=Islet+neogenesis+associated+protein+transgenic+mice+are+resistant+to+hyperglycemia+induced+by+streptozotocin&rft.au=Taylor-Fishwick%2C+David+A%3BBowman%2C+Angela%3BHamblet%2C+Natasha%3BBernard%2C+Paul%3BHarlan%2C+David+M%3BVinik%2C+Aaron+I&rft.aulast=Taylor-Fishwick&rft.aufirst=David&rft.date=2006-09-01&rft.volume=190&rft.issue=3&rft.spage=729&rft.isbn=&rft.btitle=&rft.title=Journal+of+Endocrinology&rft.issn=00220795&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Data processing; Pancreas; Glucose; Islets of Langerhans; Homeostasis; Transgenic mice; Streptozocin; biomarkers; Acinar cells; Insulin; Diabetes mellitus; Blood; Stem cells; Hyperglycemia ER - TY - JOUR T1 - Toxicogenomics-A New Systems Toxicology Approach to Understanding of Gene-Environment Interactions AN - 19837608; 7191066 AB - Toxicogenomics is a new interdisciplinary area of research being developed to monitor the expression of multiple genes, proteins, and metabolites simultaneously. It combines new technologies in genomics, proteomics, and metabolomics with traditional tools of pathology and toxicology to study biological response to drugs and other environmental xenobiotics. The biological response to environmental exposure is so complex and involves so many interactive factors that the use of a systems biology analytical approach is required. In my opinion, the development of the field of toxicogenomics will provide powerful and relatively inexpensive tools to identify biomarkers and to relate exposure and biological events during disease progression. JF - Annals of the New York Academy of Sciences AU - Olden, Kenneth AD - National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 703 EP - 706 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts; Genetics Abstracts KW - Metabolites KW - proteomics KW - Xenobiotics KW - genomics KW - Drugs KW - biomarkers KW - metabolomics KW - X 24310:Pharmaceuticals KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19837608?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Toxicogenomics-A+New+Systems+Toxicology+Approach+to+Understanding+of+Gene-Environment+Interactions&rft.au=Olden%2C+Kenneth&rft.aulast=Olden&rft.aufirst=Kenneth&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=703&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Metabolites; genomics; Xenobiotics; proteomics; biomarkers; Drugs; metabolomics ER - TY - JOUR T1 - Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C) AN - 19835669; 7060508 AB - BACKGROUND: During pregnancy, the placenta may become exposed to micro-organisms, such as viruses, which may pose a substantial threat to the embryo/fetus well-being. Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs). METHODS: The objective of this study was to determine whether the engagement of TLR-3 with viral dsRNA by first-trimester trophoblast could induce the production of factors necessary to generate an antiviral response. Therefore, trophoblast cells were exposed to the TLR-3 agonist, Poly(I : C). RESULTS: We report that following stimulation with Poly(I : C), first-trimester trophoblast cells produce interferon beta (IFN beta ) and secretory leukocyte protease inhibitor (SLPI), as well as the intracellular factors 2',5'-oligoadenylate synthetase (OAS), Myxovirus-resistance A (MxA) and apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G). This response is TLR-3 specific because the TLR-4 ligand, lipopolysaccharide (LPS), had no effect on the production of these antimicrobial factors. Furthermore, we describe a positive feedback mechanism in which IFN beta enhances the antiviral response by promoting the production of OAS, MxA and APOBEC3G. CONCLUSIONS: These findings suggest that trophoblast cells are able to recognize and specifically respond to viral products in a highly regulated fashion and that the placenta may be pivotal in the control of viral infections at the maternal-fetal interface. JF - Human Reproduction AU - Abrahams, Vikki M AU - Schaefer, Todd M AU - Fahey, John V AU - Visintin, Irene AU - Wright, Jacqueline A AU - Aldo, Paulomi B AU - Romero, Roberto AU - Wira, Charles R AU - Mor, Gil AD - Department of Obstetrics, Gynecology & Reproductive Sciences, Yale University School of Medicine, New Haven, CT. Department of Physiology, Dartmouth Medical School, Lebanon, NH and. The Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland and Detroit, MI, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 2432 EP - 2439 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 21 IS - 9 SN - 0268-1161, 0268-1161 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Immunology Abstracts KW - beta -Interferon KW - Apolipoprotein B KW - Double-stranded RNA KW - Proteinase inhibitors KW - Leukocytes KW - Trophoblasts KW - Pathogens KW - Infection KW - Fetuses KW - Pregnancy KW - Antimicrobial agents KW - Placenta KW - RNA editing KW - Lipopolysaccharides KW - Embryos KW - Feedback KW - Toll-like receptors KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19835669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+Reproduction&rft.atitle=Expression+and+secretion+of+antiviral+factors+by+trophoblast+cells+following+stimulation+by+the+TLR-3+agonist%2C+Poly%28I+%3A+C%29&rft.au=Abrahams%2C+Vikki+M%3BSchaefer%2C+Todd+M%3BFahey%2C+John+V%3BVisintin%2C+Irene%3BWright%2C+Jacqueline+A%3BAldo%2C+Paulomi+B%3BRomero%2C+Roberto%3BWira%2C+Charles+R%3BMor%2C+Gil&rft.aulast=Abrahams&rft.aufirst=Vikki&rft.date=2006-09-01&rft.volume=21&rft.issue=9&rft.spage=2432&rft.isbn=&rft.btitle=&rft.title=Human+Reproduction&rft.issn=02681161&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - beta -Interferon; Apolipoprotein B; Double-stranded RNA; Leukocytes; Proteinase inhibitors; Trophoblasts; Pathogens; Infection; Fetuses; Antimicrobial agents; Pregnancy; Placenta; Lipopolysaccharides; RNA editing; Feedback; Embryos; Toll-like receptors ER - TY - JOUR T1 - A set of recombineering plasmids for gram-negative bacteria AN - 19775935; 7081340 AB - We have constructed a set of plasmids that can be used to express recombineering functions in some gram-negative bacteria, thereby facilitating in vivo genetic manipulations. These plasmids include an origin of replication and a segment of the bacteriophage lambda genome comprising the red genes (exo, bet and gam) under their native control. These constructs do not require the anti-termination event normally required for Red expression, making their application more likely in divergent species. Some of the plasmids have temperature-sensitive replicons to simplify curing. In creating these vectors we developed two useful recombineering applications. Any gene linked to a drug marker can be retrieved by gap-repair using only a plasmid origin and target homologies. A plasmid origin of replication can be changed to a different origin by targeted replacement, to potentially alter its copy number and host range. Both these techniques will prove useful for manipulation of plasmids in vivo. Most of the Red plasmid constructs catalyzed efficient recombination in E. coli with a low level of uninduced background recombination. These Red plasmids have been successfully tested in Salmonella, and we anticipate that that they will provide efficient recombination in other related gram-negative bacteria. JF - Gene AU - Datta, S AU - Costantino, N AU - Court, D L AD - Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA, court@ncifcrf.gov Y1 - 2006/09/01/ PY - 2006 DA - 2006 Sep 01 SP - 109 EP - 115 VL - 379 SN - 0378-1119, 0378-1119 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Genomes KW - Phages KW - Host range KW - Replication KW - Plasmids KW - copy number KW - Recombination KW - Homology KW - Gram-negative bacteria KW - Escherichia coli KW - Replication origins KW - Salmonella KW - Drugs KW - J 02310:Genetics & Taxonomy KW - V 22320:Replication KW - G 07770:Bacteria KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19775935?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gene&rft.atitle=A+set+of+recombineering+plasmids+for+gram-negative+bacteria&rft.au=Datta%2C+S%3BCostantino%2C+N%3BCourt%2C+D+L&rft.aulast=Datta&rft.aufirst=S&rft.date=2006-09-01&rft.volume=379&rft.issue=&rft.spage=109&rft.isbn=&rft.btitle=&rft.title=Gene&rft.issn=03781119&rft_id=info:doi/10.1016%2Fj.gene.2006.04.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; Genomes; Recombination; Host range; Homology; Replication; Gram-negative bacteria; Replication origins; Plasmids; Drugs; copy number; Escherichia coli; Salmonella DO - http://dx.doi.org/10.1016/j.gene.2006.04.018 ER - TY - JOUR T1 - Human cytidine deaminase: A three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue AN - 19771171; 7047212 AB - Cytidine deaminase (CDA) is a cytosolic metalloprotein whose functional unit can be either a homotetramer (T-CDA) or a homodimer (D-CDA), depending on the species. In 1994, the first crystal structure of the dimeric Escherichia coli CDA has been published. However, a crystal structure of a tetrameric CDA was not determined until 2002. Prior to the disclosure of the experimentally elucidated structure of a tetrameric CDA, we derived a homology model of the human T-CDA employing the crystal structure of the dimeric E. coli CDA as a template. The comparison of our theoretical model with the crystal structure of the human T-CDA, subsequently published in 2004, validates our prediction: not only of the structural features of the monomer and the details of the binding site, but also the multimeric arrangement of the subunits were determined with high accuracy in our model. By means of a phylogenetic analysis conducted on CDAs from various organisms, we demonstrate that the E. coli CDA is one of the furthest known homologues of the human enzyme. Nonetheless, despite the evolutionary distance and, more importantly, the different multimeric arrangement of their functional units, the E. coli CDA proved to have all the necessary information to accurately infer the structure of its human homologue. JF - Journal of Molecular Graphics and Modelling AU - Costanzi, Stefano AU - Vincenzetti, Silvia AU - Cristalli, Gloria AU - Vita, Alberto AD - Computational Chemistry Core Laboratory, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 12A Center Drive Rm 4051 MSC 5646, Bethesda, MD 20892-0810, USA, stefanoc@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 10 EP - 16 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 25 IS - 1 SN - 1093-3263, 1093-3263 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts KW - Cytidine deaminase KW - Homology modeling KW - Sequence alignment KW - Phylogenetic analysis KW - Evolution KW - Monomers KW - Phylogeny KW - Homology KW - Escherichia coli KW - Crystal structure KW - Enzymes KW - Models KW - J 02310:Genetics & Taxonomy KW - W 30940:Products UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19771171?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Molecular+Graphics+and+Modelling&rft.atitle=Human+cytidine+deaminase%3A+A+three-dimensional+homology+model+of+a+tetrameric+metallo-enzyme+inferred+from+the+crystal+structure+of+a+distantly+related+dimeric+homologue&rft.au=Costanzi%2C+Stefano%3BVincenzetti%2C+Silvia%3BCristalli%2C+Gloria%3BVita%2C+Alberto&rft.aulast=Costanzi&rft.aufirst=Stefano&rft.date=2006-09-01&rft.volume=25&rft.issue=1&rft.spage=10&rft.isbn=&rft.btitle=&rft.title=Journal+of+Molecular+Graphics+and+Modelling&rft.issn=10933263&rft_id=info:doi/10.1016%2Fj.jmgm.2005.10.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Phylogeny; Monomers; Homology; Crystal structure; Enzymes; Cytidine deaminase; Evolution; Models; Escherichia coli DO - http://dx.doi.org/10.1016/j.jmgm.2005.10.008 ER - TY - JOUR T1 - A microtiter plate fraction collector for the sequencing of radioactive phosphorylated peptides AN - 19727270; 7536787 JF - Analytical Biochemistry AU - Guszczynski, Tad AU - Specht, Suzanne I AU - Copeland, Terry D AD - Laboratory of Protein Dynamics and Signaling, National Cancer Institute-Frederick, Frederick, MD 21702, USA, guszczyn@ncifcrf.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 151 EP - 153 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 356 IS - 1 SN - 0003-2697, 0003-2697 KW - Biotechnology and Bioengineering Abstracts KW - Assays KW - Peptides KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19727270?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Biochemistry&rft.atitle=A+microtiter+plate+fraction+collector+for+the+sequencing+of+radioactive+phosphorylated+peptides&rft.au=Guszczynski%2C+Tad%3BSpecht%2C+Suzanne+I%3BCopeland%2C+Terry+D&rft.aulast=Guszczynski&rft.aufirst=Tad&rft.date=2006-09-01&rft.volume=356&rft.issue=1&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Analytical+Biochemistry&rft.issn=00032697&rft_id=info:doi/10.1016%2Fj.ab.2006.05.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Assays; Peptides DO - http://dx.doi.org/10.1016/j.ab.2006.05.034 ER - TY - JOUR T1 - Midlife Physical Activity and Mobility in Older Age The InCHIANTI Study AN - 19630473; 8791107 AB - Abstract not available. JF - American Journal of Preventive Medicine AU - Patel, Kushang V AU - Coppin, Antonia K AU - Manini, Todd M AU - Lauretani, Fulvio AU - Bandinelli, Stefania AU - Ferrucci, Luigi AU - Guralnik, Jack M AD - Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, Patelku@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 217 EP - 224 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 31 IS - 3 SN - 0749-3797, 0749-3797 KW - Physical Education Index KW - Gerontology KW - Exercise KW - Movement KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19630473?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Preventive+Medicine&rft.atitle=Midlife+Physical+Activity+and+Mobility+in+Older+Age+The+InCHIANTI+Study&rft.au=Patel%2C+Kushang+V%3BCoppin%2C+Antonia+K%3BManini%2C+Todd+M%3BLauretani%2C+Fulvio%3BBandinelli%2C+Stefania%3BFerrucci%2C+Luigi%3BGuralnik%2C+Jack+M&rft.aulast=Patel&rft.aufirst=Kushang&rft.date=2006-09-01&rft.volume=31&rft.issue=3&rft.spage=217&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Preventive+Medicine&rft.issn=07493797&rft_id=info:doi/10.1016%2Fj.amepre.2006.05.005 LA - English DB - Physical Education Index N1 - Date revised - 2009-02-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Exercise; Movement; Gerontology DO - http://dx.doi.org/10.1016/j.amepre.2006.05.005 ER - TY - JOUR T1 - Bacterial expression of functional, biotinylated peripheral cannabinoid receptor CB2 AN - 19607416; 8586310 AB - A biotin-protein ligase recognition site (BRS) was inserted into a polypeptide comprised of the maltose- binding protein, the peripheral cannabinoid receptor (CB2), thioredoxin A, and a polyhistidine tag at the carboxy terminus. Expression levels of the recombinant receptor in Escherichia coli BL21(DE3) cells were [not, vert, similar]1 mg per liter of bacterial culture. The biotinylated CB2-fusion fully retained its ligand-binding capacity. Introduction of the BRS at the C-terminus of the CB2 fusion protein (construct CB2- 109) resulted in its complete in vivo biotinylation; the biotinylated protein was streptavidin-binding competent. Positioning of the BRS near the N-terminus of CB2 (CB2-112) resulted in a very low level of biotinylation in vivo. However, the detergent solubilized and purified CB2-112 fusion protein were successfully biotinylated in vitro by action of a BirA biotin-protein ligase. The biotinylated CB2-112 fusion protein was cleaved by the tobacco etch virus protease at specifically inserted sites, and deposited onto monomeric avidin agarose beads. Biotinylation of the recombinant CB2 receptor enabled not only purification but also immobilization of the GPCR on a solid support in homogeneous orientation which is beneficial for subsequent structural characterization. JF - Protein Expression and Purification AU - Krepkiy, Dmitriy AU - Wong, Karen AU - Gawrisch, Klaus AU - Yeliseev, Alexei AD - Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcoholism and Alcohol Abuse, National Institutes of Health, 5625 Fishers Lane, Bethesda, MD 20892, USA, yeliseeva@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 60 EP - 70 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 49 IS - 1 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology KW - Peripheral cannabinoid receptor CB2 KW - Biotinylation KW - GPCR KW - Affinity purification KW - Expression tag removal KW - Thioredoxin KW - double prime G protein-coupled receptors KW - Detergents KW - C-Terminus KW - Cell culture KW - protein purification KW - polyhistidine KW - N-Terminus KW - Avidin KW - Cannabinoid CB2 receptors KW - Escherichia coli KW - Tobacco etch virus KW - Proteinase KW - Fusion protein KW - Immobilization KW - J 02410:Animal Diseases KW - A 01360:Plant Diseases KW - V 22410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Bacterial+expression+of+functional%2C+biotinylated+peripheral+cannabinoid+receptor+CB2&rft.au=Krepkiy%2C+Dmitriy%3BWong%2C+Karen%3BGawrisch%2C+Klaus%3BYeliseev%2C+Alexei&rft.aulast=Krepkiy&rft.aufirst=Dmitriy&rft.date=2006-09-01&rft.volume=49&rft.issue=1&rft.spage=60&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.03.002 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Thioredoxin; Detergents; double prime G protein-coupled receptors; C-Terminus; Cell culture; protein purification; polyhistidine; Biotinylation; N-Terminus; Avidin; Cannabinoid CB2 receptors; Proteinase; Fusion protein; Immobilization; Escherichia coli; Tobacco etch virus DO - http://dx.doi.org/10.1016/j.pep.2006.03.002 ER - TY - JOUR T1 - Expression and purification of recombinant human alpha -defensins in Escherichia coli AN - 19607359; 8586304 AB - Different strategies have been developed to produce small antimicrobial peptides (AMPs) using recombinant techniques. Up to now, all efforts to obtain larger quantities of active recombinant human alpha - defensins have been only moderately successful. Here we report an effective method of biosynthesis of human alpha -defensins (hNP-1 to hNP-3 and hD-5 and hD-6) in the Escherichia coli. All the peptides, expressed as insoluble fusions with the peptide encoded by a portion of E. coli tryptophan operon (trp Delta LE 1413 polypeptide), were isolated from the inclusion bodies by immobilized metal affinity chromatography (IMAC) and separated from the fusion leader by chemical cleavage. Fully reduced peptides that were purified according to a straightforward protocol were subsequently folded, oxidized, and subjected to functional and structural analyses. With the exception of hD-6, all recombinant alpha -defensins exhibit expected anti-E. coli activity, as measured by the colony counting method. The method described in this report is a low- cost, efficient way of generating alpha -defensins in quantities ranging from milligrams to grams. JF - Protein Expression and Purification AU - Pazgier, Marzena AU - Lubkowski, Jacek AD - Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, MD 21702, USA, jacek@ncifcrf.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1 EP - 8 PB - Elsevier Science, P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 49 IS - 1 SN - 1046-5928, 1046-5928 KW - Microbiology Abstracts B: Bacteriology; Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Human alpha -defensins KW - Expression KW - Fusion protein KW - Purification KW - Antibacterial activity KW - Affinity chromatography KW - Metals KW - Colonies KW - Defensins KW - Structure-function relationships KW - Tryptophan operon KW - Escherichia coli KW - Counting methods KW - Inclusion bodies KW - protein purification KW - Antimicrobial peptides KW - J 02310:Genetics & Taxonomy KW - A 01340:Antibiotics & Antimicrobials KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19607359?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Expression+and+Purification&rft.atitle=Expression+and+purification+of+recombinant+human+alpha+-defensins+in+Escherichia+coli&rft.au=Pazgier%2C+Marzena%3BLubkowski%2C+Jacek&rft.aulast=Pazgier&rft.aufirst=Marzena&rft.date=2006-09-01&rft.volume=49&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Protein+Expression+and+Purification&rft.issn=10465928&rft_id=info:doi/10.1016%2Fj.pep.2006.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-11-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Affinity chromatography; Metals; Defensins; Colonies; Tryptophan operon; Structure-function relationships; Counting methods; Inclusion bodies; protein purification; Antimicrobial peptides; Escherichia coli DO - http://dx.doi.org/10.1016/j.pep.2006.05.004 ER - TY - JOUR T1 - Interventional radiography and mortality risks in U.S. radiologic technologists AN - 19569525; 8825169 AB - Abstract With the exponential increase in minimally invasive fluoroscopically guided interventional radiologic procedures, concern has increased about the health effects on staff and patients of radiation exposure from these procedures. There has been no systematic epidemiologic investigation to quantify serious disease risks or mortality. To quantify all-cause, circulatory system disease and cancer mortality risks in U.S. radiologic technologists who work with interventional radiographic procedures, we evaluated mortality risks in a nationwide cohort of 88,766 U.S. radiologic technologists (77% female) who completed a self-administered questionnaire during 1994-1998 and were followed through 31 December 2003. We obtained information on work experience, types of procedures (including fluoroscopically guided interventional procedures), and protective measures plus medical, family cancer history, lifestyle, and reproductive information. Cox proportional hazards regression models were used to compute relative risks (RRs) with 95% confidence intervals (CIs). Between completion of the questionnaire and the end of follow-up, there were 3,581 deaths, including 1,209 from malignancies and 979 from circulatory system diseases. Compared to radiologic technologists who never or rarely performed or assisted with fluoroscopically guided interventional procedures, all-cause mortality risks were not increased among those working on such procedures daily. Similarly, there was no increased risk of mortality resulting from all circulatory system diseases combined, all cancers combined, or female breast cancer among technologists who daily performed or assisted with fluoroscopically guided interventional procedures. Based on small numbers of deaths (n=151), there were non-significant excesses (40%-70%) in mortality from cerebrovascular disease among technologists ever working with these procedures. The absence of significantly elevated mortality risks in radiologic technologists reporting the highest frequency of interventional radiography procedures must be interpreted cautiously in light of the small number of deaths during the relatively short follow-up. The present study cannot rule out increased risks of cerebrovascular disease, specific cancers, and diseases with low case-fatality rates or a long latency period preceding death. JF - Pediatric Radiology AU - Linet, Martha S AU - Hauptmann, Michael AU - Freedman, DMichal AU - Alexander, Bruce H AU - Miller, Jeremy AU - Sigurdson, Alice J AU - Doody, Michele Morin AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA, linetm@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 113 EP - 120 PB - Springer-Verlag, Tiergartenstrasse 17 VL - 36 IS - 2 SN - 0301-0449, 0301-0449 KW - Microbiology Abstracts A: Industrial & Applied Microbiology KW - Risk assessment KW - Mortality KW - Inventories KW - Invasiveness KW - Cerebrovascular diseases KW - Models KW - Malignancy KW - Radiation KW - Regression analysis KW - Breast cancer KW - Radiography KW - Circulatory system KW - A 01300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19569525?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pediatric+Radiology&rft.atitle=Interventional+radiography+and+mortality+risks+in+U.S.+radiologic+technologists&rft.au=Linet%2C+Martha+S%3BHauptmann%2C+Michael%3BFreedman%2C+DMichal%3BAlexander%2C+Bruce+H%3BMiller%2C+Jeremy%3BSigurdson%2C+Alice+J%3BDoody%2C+Michele+Morin&rft.aulast=Linet&rft.aufirst=Martha&rft.date=2006-09-01&rft.volume=36&rft.issue=2&rft.spage=113&rft.isbn=&rft.btitle=&rft.title=Pediatric+Radiology&rft.issn=03010449&rft_id=info:doi/10.1007%2Fs00247-006-0224-0 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-01-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Risk assessment; Inventories; Mortality; Invasiveness; Malignancy; Radiation; Cerebrovascular diseases; Regression analysis; Breast cancer; Radiography; Models; Circulatory system DO - http://dx.doi.org/10.1007/s00247-006-0224-0 ER - TY - JOUR T1 - Toxicoproteomics in Liver Injury and Inflammation AN - 19554387; 7220756 AB - Toxicoproteomics, in applying proteomics to toxicology, seeks to identify critical proteins and pathways in biological systems responding to adverse chemical exposures and environmental stressors using global protein expression technologies. Toxicoproteomics is being exploited for the discovery of new biomarkers and toxicity signatures in target organs, such as liver, in major biological processes, such as inflammation, in mapping serum, plasma, and other biofluid proteomes, and in parallel proteomic and transcriptomic studies. The new field of toxicoproteomics is uniquely positioned toward discovery of new biomarkers and signatures of tissue injury and a better understanding of protein expression responses during toxicity and environmental disease. JF - Annals of the New York Academy of Sciences AU - Alex Merrick, B AD - Address for correspondence: B. Alex Merrick, National Institutes of Environmental Health Sciences, 111 TW Alexander Dr, P.O. Box 12233, Research Triangle Park, Durham, NC 27709. Voice: 919-541-1531, merrick@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 707 EP - 717 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 IS - 1 SN - 0077-8923, 0077-8923 KW - Toxicology Abstracts KW - Injuries KW - Liver KW - Toxicity KW - proteomics KW - biomarkers KW - Inflammation KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19554387?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Toxicoproteomics+in+Liver+Injury+and+Inflammation&rft.au=Alex+Merrick%2C+B&rft.aulast=Alex+Merrick&rft.aufirst=B&rft.date=2006-09-01&rft.volume=1076&rft.issue=1&rft.spage=707&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1371.017 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-03-01 N1 - SuppNotes - Figures, 2; references, 23. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Injuries; Liver; proteomics; Toxicity; biomarkers; Inflammation DO - http://dx.doi.org/10.1196/annals.1371.017 ER - TY - JOUR T1 - Do Recommended Driving Limits Affect Teen-Reported Traffic Violations and Crashes During the First 12 Months of Independent Driving? AN - 19521315; 7151269 AB - Objectives. Motor vehicle crashes are highly elevated among newly licensed teenage drivers. Limits on high-risk driving conditions by driver licensing policies and parents can protect novice teens from negative driving outcomes, while they experience and driving proficiency. The purpose of this research was to evaluate the effects of strict parent-imposed driving limits on driving outcomes during the first year of licensure. Methods. A sample of 3,743 Connecticut teens was recruited and randomized to the Checkpoints Program or comparison condition. Assessments conducted at baseline, licensure, 3-, 6-, and 12-months postlicensure included parent-imposed driving limits, traffic violations, and crashes. Bivariate and multivariate analyses were conducted to assess the effects of strict parent limits on traffic violations and crashes during the first year of licensure. Results. Thirty percent of teens reported at least one traffic violation and 40% reported at least one crash. More strict parent-imposed limits at licensure, 3-, 6-, and 12-months postlicensure, were associated with fewer violations and crashes in multivariate analyses. Notably, adherence to recommended night curfew was consistently associated with fewer violations and crashes. Conclusions. The findings indicate that strict parent-imposed limits may protect novice teen drivers from negative driving outcomes. JF - Traffic Injury Prevention AU - Simons-Morton, B AU - Hartos, J L AU - Leaf, WA AU - Preusser, D F AD - Prevention Research Branch, DESPR, NICHD, Bethesda, MD, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 238 EP - 247 VL - 7 IS - 3 SN - 1538-9588, 1538-9588 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Accidents KW - Injuries KW - USA, Connecticut KW - Licensing KW - prevention KW - traffic safety KW - R2 23020:Technological risks KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19521315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic+Injury+Prevention&rft.atitle=Do+Recommended+Driving+Limits+Affect+Teen-Reported+Traffic+Violations+and+Crashes+During+the+First+12+Months+of+Independent+Driving%3F&rft.au=Simons-Morton%2C+B%3BHartos%2C+J+L%3BLeaf%2C+WA%3BPreusser%2C+D+F&rft.aulast=Simons-Morton&rft.aufirst=B&rft.date=2006-09-01&rft.volume=7&rft.issue=3&rft.spage=238&rft.isbn=&rft.btitle=&rft.title=Traffic+Injury+Prevention&rft.issn=15389588&rft_id=info:doi/10.1080%2F15389580600668842 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Accidents; Injuries; Licensing; prevention; traffic safety; USA, Connecticut DO - http://dx.doi.org/10.1080/15389580600668842 ER - TY - JOUR T1 - The effect on teen driving outcomes of the Checkpoints Program in a state- wide trial AN - 19519764; 6976060 AB - Crash rates among teenagers are highly elevated during the first months of licensure. Parent-imposed driving restrictions on initial driving privileges can reduce exposure to high-risk driving conditions, thus reducing crash risk while teens' driving proficiency develops. This report describes the effect of the Checkpoints Program on driving limits and outcomes. Connecticut teens who obtained a learners permit over a 9-month period were recruited, providing a final sample of 3743 who obtained driver licenses. Families were randomized to the intervention or comparison condition. Intervention families received by mail a series of persuasive communications related to high-risk teen driving and a parent-teen driving agreement, while comparison families received on the same schedule general information on driving and vehicle maintenance. Relative to the comparison group, teens and parents in the Checkpoints Program reported significantly greater limits on high-risk teen driving conditions at licensure, 3-, and 6-months post-licensure; and intervention teens reported significantly less risky driving at each reporting period. By the 12-month follow up teens in the intervention group were significantly less likely than those in the comparison group to have had a traffic violation. However, no treatment group effect was found for crashes. This is the first study to report significant effects on teen driving behavior and performance of education designed to increase parental-imposed teen driving limits. JF - Accident Analysis & Prevention AU - Simons-Morton, Bruce G AU - Hartos, Jessica L AU - Leaf, William A AU - Preusser, David F AD - National Institute of Child Health and Human Development, Division of Epidemiology, Statistics, and Prevention Research, 6100 Executive Blvd., Rockville, MD 20852, USA, MortonB@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 907 EP - 912 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 38 IS - 5 SN - 0001-4575, 0001-4575 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Behavioral intervention KW - Persuasion KW - Education KW - Adolescents KW - Parenting KW - Parent limits KW - Teen passengers KW - Night driving KW - Risky driving KW - Traffic violations KW - Crashes KW - Accidents KW - Communications KW - USA, Connecticut KW - driving ability KW - prevention KW - traffic safety KW - R2 23020:Technological risks KW - H 2000:Transportation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19519764?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accident+Analysis+%26+Prevention&rft.atitle=The+effect+on+teen+driving+outcomes+of+the+Checkpoints+Program+in+a+state-+wide+trial&rft.au=Simons-Morton%2C+Bruce+G%3BHartos%2C+Jessica+L%3BLeaf%2C+William+A%3BPreusser%2C+David+F&rft.aulast=Simons-Morton&rft.aufirst=Bruce&rft.date=2006-09-01&rft.volume=38&rft.issue=5&rft.spage=907&rft.isbn=&rft.btitle=&rft.title=Accident+Analysis+%26+Prevention&rft.issn=00014575&rft_id=info:doi/10.1016%2Fj.aap.2006.03.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Education; Accidents; Communications; driving ability; prevention; Adolescents; traffic safety; USA, Connecticut DO - http://dx.doi.org/10.1016/j.aap.2006.03.001 ER - TY - JOUR T1 - Pesticides and Adult Respiratory Outcomes in the Agricultural Health Study AN - 19507055; 7191032 AB - In the 1700s, Bernardino Ramazzini was among the first to describe respiratory disease among agricultural workers. Since then, farmers continue to have higher rates of respiratory illnesses, even as changes occur in occupational and environmental exposures on farms. While grain and animal exposures have been well studied for their role in agricultural lung diseases, pesticide exposures have not. Using the Agricultural Health Study, a prospective cohort study of similar to 89,000 licensed pesticide applicators and their spouses in Iowa and North Carolina, we are currently assessing the association of pesticides with respiratory outcomes, including wheeze, adult asthma, farmer's lung, and chronic bronchitis. At enrollment (1993-1997), 19% of farmers and 22% of commercial pesticide applicators reported wheeze in the previous year. Using logistic regression models adjusted for age, state, smoking status, and body mass index, we evaluated the association of 40 individual pesticides with wheeze within these two groups separately. In both groups, we observed strong evidence of an association of organophosphates with wheeze. For farmers, the organophosphates chlorpyrifos, malathion, and parathion were positively associated with wheeze; for the commercial applicators, the organophosphates chlorpyrifos, dichlorvos, and phorate were positively associated with wheeze. Chlorpyrifos was strongly associated with wheeze in a dose-dependent manner in both groups; use of chlorpyrifos for at least 20 days per year had an odds ratio of 1.48 (95% confidence interval [CI] = 1.00-2.19) for farmers and 1.96 (95% CI = 1.05-3.66) for commercial applicators. Our wheeze results are consistent with recent animal models that support a role for organophosphates and respiratory outcomes. JF - Annals of the New York Academy of Sciences AU - Hoppin, Jane A AU - Umbach, David M AU - London, Stephanie J AU - Lynch, Charles F AU - Alavanja, Michael CR AU - Sandler, Dale P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, North Carolina 27709-2233, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 343 EP - 354 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1076 SN - 0077-8923, 0077-8923 KW - Health & Safety Science Abstracts; Pollution Abstracts KW - USA, North Carolina KW - Organophosphates KW - Animal models KW - Respiratory diseases KW - Agrochemicals KW - Malathion KW - Chlorpyrifos KW - Smoking KW - USA, Iowa KW - Lung KW - body mass KW - farms KW - Pesticides KW - Parathion KW - H 1000:Occupational Safety and Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19507055?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Apollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Pesticides+and+Adult+Respiratory+Outcomes+in+the+Agricultural+Health+Study&rft.au=Hoppin%2C+Jane+A%3BUmbach%2C+David+M%3BLondon%2C+Stephanie+J%3BLynch%2C+Charles+F%3BAlavanja%2C+Michael+CR%3BSandler%2C+Dale+P&rft.aulast=Hoppin&rft.aufirst=Jane&rft.date=2006-09-01&rft.volume=1076&rft.issue=&rft.spage=343&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Chlorpyrifos; Smoking; body mass; Lung; Organophosphates; farms; Pesticides; Animal models; Respiratory diseases; Agrochemicals; Malathion; Parathion; USA, North Carolina; USA, Iowa ER - TY - JOUR T1 - OP09.05: The use of inversion mode and 3D manual segmentation in volume measurement of fetal fluid-filled structures: a comparison with VOCALTM AN - 19500673; 8633628 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Nien, J K AU - Goncalves, L F AU - Espinoza, J AU - Lee, W AU - Soto, E AU - Erez, O AU - Fisher, L AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 472 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Inversion KW - Segmentation KW - Obstetrics KW - Ultrasound KW - Fetuses KW - G 07880:Human Genetics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19500673?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OP09.05%3A+The+use+of+inversion+mode+and+3D+manual+segmentation+in+volume+measurement+of+fetal+fluid-filled+structures%3A+a+comparison+with+VOCALTM&rft.au=Kusanovic%2C+J+P%3BNien%2C+J+K%3BGoncalves%2C+L+F%3BEspinoza%2C+J%3BLee%2C+W%3BSoto%2C+E%3BErez%2C+O%3BFisher%2C+L%3BRomero%2C+R&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=472&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.3248 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Gynecology; Inversion; Segmentation; Ultrasound; Obstetrics; Fetuses DO - http://dx.doi.org/10.1002/uog.3248 ER - TY - JOUR T1 - Acetaminophen-induced Liver Injury Is Attenuated in Male Glutamate-cysteine Ligase Transgenic Mice AN - 19467573; 7123274 AB - Acetaminophen overdose is a leading cause of drug-related acute liver failure in the United States. Glutathione, a tripeptide antioxidant protects cells against oxidative damage from reactive oxygen species and plays a crucial role in the detoxification of xenobiotics, including acetaminophen. Glutathione is synthesized in a two-step enzymatic reaction. Glutamate-cysteine ligase carries out the rate-limiting and first step in glutathione synthesis. We have generated C57Bl/6 mice that conditionally overexpress glutamate-cysteine ligase, and report here their resistance to acetaminophen-induced liver injury. Indices of liver injury included histopathology and serum alanine aminotransferase activity. Male transgenic mice induced to overexpress glutamate-cysteine ligase exhibited resistance to acetaminophen-induced liver injury when compared with acetaminophen-treated male mice carrying, but not expressing glutamate-cysteine ligase transgenes, or to female glutamate-cysteine ligase transgenic mice. We conclude that glutamate-cysteine ligase activity is an important factor in determining acetaminophen-induced liver injury in C57Bl/6 male mice. Because people are known to vary in their glutamate-cysteine ligase activity, this enzyme may also be an important determinant of sensitivity to acetaminophen-induced liver injury in humans. JF - Journal of Biological Chemistry AU - Botta, Dianne AU - Shi, Shengli AU - White, Collin C AU - Dabrowski, Michael J AU - Keener, Cassie L AU - Srinouanprachanh, Sengkeo L AU - Farin, Federico M AU - Ware, Carol B AU - Ladiges, Warren C AU - Pierce, Robert H AU - Fausto, Nelson AU - Kavanagh, Terrance J AD - Departments of Environmental and Occupational Health Sciences, Comparative Medicine, and Pathology, and UW/NIEHS Center for Ecogenetics and Environmental Health, University of Washington, Seattle, Washington 68105 and the Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 28865 EP - 28875 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 39 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Detoxification KW - Antioxidants KW - Liver diseases KW - Injuries KW - Glutathione KW - Enzymes KW - Glutamate-cysteine ligase KW - Xenobiotics KW - Alanine transaminase KW - Transgenic mice KW - Overdose KW - Reactive oxygen species KW - Liver KW - Acetaminophen KW - W 30925:Genetic Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19467573?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=Acetaminophen-induced+Liver+Injury+Is+Attenuated+in+Male+Glutamate-cysteine+Ligase+Transgenic+Mice&rft.au=Botta%2C+Dianne%3BShi%2C+Shengli%3BWhite%2C+Collin+C%3BDabrowski%2C+Michael+J%3BKeener%2C+Cassie+L%3BSrinouanprachanh%2C+Sengkeo+L%3BFarin%2C+Federico+M%3BWare%2C+Carol+B%3BLadiges%2C+Warren+C%3BPierce%2C+Robert+H%3BFausto%2C+Nelson%3BKavanagh%2C+Terrance+J&rft.aulast=Botta&rft.aufirst=Dianne&rft.date=2006-09-01&rft.volume=281&rft.issue=39&rft.spage=28865&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Glutamate-cysteine ligase; Liver; Injuries; Transgenic mice; Glutathione; Acetaminophen; Liver diseases; Alanine transaminase; Overdose; Antioxidants; Enzymes; Reactive oxygen species; Detoxification; Xenobiotics ER - TY - JOUR T1 - Increased oxygen consumption in the somatosensory cortex of alpha -chloralose anesthetized rats during forepaw stimulation determined using MRS at 11.7 Tesla AN - 19464651; 7055729 AB - The significance of changes in cerebral oxygen consumption in focally activated brain tissue is still controversial. Since the rate of cerebral oxygen consumption is tightly coupled to that of tricarboxylic acid cycle which can be measured from the turnover kinetics of [4- super(13)C]glutamate using in vivo H{ super(13)C} magnetic resonance spectroscopy, changes in tricarboxylic acid cycle flux rate were assessed in primary somatosensory cortex of alpha -chloralose anesthetized rats during electrical forepaw stimulation. With markedly improved H{ super(13)C} magnetic resonance spectroscopy technique and the use of high magnetic field strength of 11.7 T accessible to the current study, [4- super(13)C]glutamate at 2.35 ppm was spectrally resolved from overlapping resonances of [4- super(13)C]glutamine at 2.46 ppm and [2- super(13)C]GABA at 2.28 ppm as well as the more distal [3- super(13)C]glutamate and [3- super(13)C]glutamine. The results showed a significantly increased V sub(TCA) in focally activated primary somatosensory cortex during forepaw stimulation, corresponding to approximately 51 +/- 27% (n = 6, mean +/- SD) increase in cerebral oxygen consumption rate. Considering the high efficiency in producing adenosine triphosphate by oxidative metabolism of glucose, the results demonstrate that aerobic oxidative metabolism provides the majority of energy required for cerebral focal activation in alpha -chloralose anesthetized rats subjected to forepaw stimulation. JF - NeuroImage AU - Yang, Jehoon AU - Shen, Jun AD - Molecular Imaging Branch, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bldg. 10, Rm. 2D51A, 9000 Rockville Pike, Bethesda, MD 20892-1527, USA, shenj@intra.nimh.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1317 EP - 1325 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Oxygen consumption KW - Brain KW - ATP KW - Glucose metabolism KW - Oxidative metabolism KW - Magnetic fields KW - Energy KW - Kinetics KW - Magnetic resonance spectroscopy KW - Tricarboxylic acid cycle KW - Cortex (somatosensory) KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464651?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Increased+oxygen+consumption+in+the+somatosensory+cortex+of+alpha+-chloralose+anesthetized+rats+during+forepaw+stimulation+determined+using+MRS+at+11.7+Tesla&rft.au=Yang%2C+Jehoon%3BShen%2C+Jun&rft.aulast=Yang&rft.aufirst=Jehoon&rft.date=2006-09-01&rft.volume=32&rft.issue=3&rft.spage=1317&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.05.010 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Oxygen consumption; Cortex (somatosensory); Tricarboxylic acid cycle; Magnetic resonance spectroscopy; Oxidative metabolism; Glucose metabolism; Magnetic fields; Brain; ATP; Kinetics; Energy DO - http://dx.doi.org/10.1016/j.neuroimage.2006.05.010 ER - TY - JOUR T1 - Extensive heterogeneity in white matter intensity in high-resolution T sub(2)- weighted MRI of the human brain at 7.0 T AN - 19464568; 7055694 AB - MRI at high magnetic field strength potentially allows for an increase in resolution and image contrast. The gains are particularly dramatic for T sub(2)- weighted imaging, which is sensitive to susceptibility effects caused by a variety of sources, including deoxyhemoglobin, iron concentration, and tissue microstructure. On the other hand, the acquisition of high quality whole brain MRI at high field is hampered by the increased inhomogeneity in B sub(o) and B sub(1) fields. In this report, high-resolution gradient echo MRI was performed using an 8-channel detector to obtain T sub(2)-weighted images over large brain areas. The high SNR achieved with the multi-channel array enabled T sub(2)- weighted images of the brain with an unprecedented spatial resolution of up to 0.2 x 0.2 x 0.5 mm super(3). This high resolution greatly facilitated the detection of microscopic susceptibility effects. In addition to the expected contrast between gray, white matter, cerebral spinal fluid, and veins, a large degree of heterogeneity in contrast was observed throughout the white matter of normal brain. The measured T sub(2) values in white matter varied as much as 30% with some of the variation apparently correlating with the presence of large fiber bundles. JF - NeuroImage AU - Li, Tie-Qiang AU - Van Gelderen, Peter AU - Merkle, Hellmut AU - Talagala, Lalith AU - Koretsky, Alan P AU - Duyn, Jeff AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive Room 10/B1D724 Bethesda, MD 20892, USA, jhd@helix.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1032 EP - 1040 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Magnetic resonance imaging KW - Brain KW - Substantia alba KW - Fibers KW - Magnetic fields KW - Cerebrospinal fluid KW - Veins KW - Iron KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464568?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Extensive+heterogeneity+in+white+matter+intensity+in+high-resolution+T+sub%282%29-+weighted+MRI+of+the+human+brain+at+7.0+T&rft.au=Li%2C+Tie-Qiang%3BVan+Gelderen%2C+Peter%3BMerkle%2C+Hellmut%3BTalagala%2C+Lalith%3BKoretsky%2C+Alan+P%3BDuyn%2C+Jeff&rft.aulast=Li&rft.aufirst=Tie-Qiang&rft.date=2006-09-01&rft.volume=32&rft.issue=3&rft.spage=1032&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.05.053 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Brain; Substantia alba; Magnetic resonance imaging; Magnetic fields; Neuroimaging; Iron; Veins; Cerebrospinal fluid; Fibers DO - http://dx.doi.org/10.1016/j.neuroimage.2006.05.053 ER - TY - JOUR T1 - Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6 - propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity AN - 19461684; 7063963 AB - Indenoisoquinolines are topoisomerase (Top) I inhibitors developed to overcome some of the limitations of camptothecins and expand their anticancer spectrum. Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6 - propylamino}-propane bis(trifluoroacetate) (NSC 727357) is a novel dimeric indenoisoquinoline derivative with potent antiproliferative activity in the NCI-60 cell line panel, promising hollow fiber activity (score of 32) and activity against xenografts. Submicromolar concentrations of the bisindenoisoquinoline NSC 727357 induce Top1 cleavage complexes at specific sites in biochemical assays. At higher concentrations, inhibition of Top1 catalytic activity and DNA intercalation is observed. NSC 727357 also induces a limited number of Top2-DNA cleavage complexes. In contrast to the effect of other Top1 inhibitors, cells treated with the bisindenoisoquinoline NSC 727357 show an arrest of cell cycle progression in G sub(1) with no significant inhibition of DNA synthesis after a short exposure to the drug. Moreover, unlike camptothecin and the indenoisoquinoline MJ-III-65 (NSC 706744, 6-[3-(2-hydroxyethyl)aminopropyl]-5,6-dihydro-5,11-diketo-2,3-dime t hoxy-(methylenedioxy)-11H-indeno[1,2-c]isoquinoline hydrochloride), the cytotoxicity of bisindenoisoquinoline NSC 727357 is only partially dependent on Top1 and p53, indicating that this drug has additional targets besides Top1 and Top2. JF - Molecular Pharmacology AU - Antony, Smitha AU - Agama, Keli K AU - Miao, Ze-Hong AU - Hollingshead, Melinda AU - Holbeck, Susan L AU - Wright, Mollie H AU - Varticovski, Lyuba AU - Nagarajan, Muthukaman AU - Morrell, Andrew AU - Cushman, Mark AU - Pommier, Yves AD - Laboratory of Molecular Pharmacology (S.A., K.K.A., Z.-H.M., Y.P.), Biological Testing Branch (M.H.), Developmental Therapeutics Program, Information Technology Branch (S.L.H.), Laboratory of Human Carcinogenesis (M.H.W., L.V.), National Cancer Institute, National Institutes of Health, Bethesda, Maryland Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1109 EP - 1120 PB - Williams & Wilkins, 351 W. Camden St. Baltimore MD 21201 USA, [URL:http://www.lww.com/] VL - 70 IS - 3 SN - 0026-895X, 0026-895X KW - Biotechnology and Bioengineering Abstracts KW - Fibers KW - DNA biosynthesis KW - Cytotoxicity KW - Cell cycle KW - Intercalation KW - Xenografts KW - Drugs KW - Camptothecin KW - DNA topoisomerase inhibitors KW - p53 protein KW - Antitumor activity KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19461684?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Pharmacology&rft.atitle=Bisindenoisoquinoline+Bis-1%2C3-%7B%285%2C6-dihydro-5%2C11-diketo-11H-indeno%5B1%2C2-c%5Disoquinoline%29-6+-+propylamino%7Dpropane+bis%28trifluoroacetate%29+%28NSC+727357%29%2C+a+DNA+Intercalator+and+Topoisomerase+Inhibitor+with+Antitumor+Activity&rft.au=Antony%2C+Smitha%3BAgama%2C+Keli+K%3BMiao%2C+Ze-Hong%3BHollingshead%2C+Melinda%3BHolbeck%2C+Susan+L%3BWright%2C+Mollie+H%3BVarticovski%2C+Lyuba%3BNagarajan%2C+Muthukaman%3BMorrell%2C+Andrew%3BCushman%2C+Mark%3BPommier%2C+Yves&rft.aulast=Antony&rft.aufirst=Smitha&rft.date=2006-09-01&rft.volume=70&rft.issue=3&rft.spage=1109&rft.isbn=&rft.btitle=&rft.title=Molecular+Pharmacology&rft.issn=0026895X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Camptothecin; Drugs; Antitumor activity; p53 protein; DNA topoisomerase inhibitors; Cell cycle; Xenografts; Cytotoxicity; DNA biosynthesis; Fibers; Intercalation ER - TY - JOUR T1 - Impaired self-awareness and theory of mind: An fMRI study of mentalizing in alexithymia AN - 19461260; 7055800 AB - Alexithymic individuals have difficulty in recognizing and describing emotions in themselves. We investigated the neuronal basis of mentalizing in alexithymia to determine whether there is a common neuronal substrate associated with knowing the mental states of the self and others. Individuals high in alexithymia (n = 16) and low in alexithymia (n = 14) were selected from a pool of 310 college students using a combination of the Toronto Alexithymia Scale (TAS-20) and the Structured Interview version of the Beth Israel Questionnaire (SIBIQ). We compared the two groups on psychological measures, including ratings of mentalizing and the Interpersonal Reactivity Index (IRI), and regional brain activation using functional magnetic resonance imaging (fMRI) during a mentalizing animation task. The results for both groups showed activation in regions associated with mentalizing: medial prefrontal cortices (MPFC), temporo-parietal junctions (TPJ), and the temporal pole (TP). Alexithymics had lower mentalizing and IRI perspective-taking scores and less activation in the right MPFC. Activity in the MPFC was positively correlated with the mentalizing score and the IRI perspective-taking score. Although there were no group differences in cerebral activity in the TPJ and the TP, the activity in the right TP had a positive correlation with mentalizing and IRI personal distress scores. These results suggest that alexithymic individuals have an impairment in mentalizing associated with an inability to take the perspective of others. Thus, the skills involved in comprehending the self and others are inter-related and play an important role in emotion regulation. JF - NeuroImage AU - Moriguchi, Yoshiya AU - Ohnishi, Takashi AU - Lane, Richard D AU - Maeda, Motonari AU - Mori, Takeyuki AU - Nemoto, Kiyotaka AU - Matsuda, Hiroshi AU - Komaki, Gen AD - Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi Cho, Kodaira City, Tokyo 187-8553, Japan, tohnishi@hotmail.com Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1472 EP - 1482 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Inventories KW - Emotions KW - Functional magnetic resonance imaging KW - Brain KW - Self KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19461260?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Impaired+self-awareness+and+theory+of+mind%3A+An+fMRI+study+of+mentalizing+in+alexithymia&rft.au=Moriguchi%2C+Yoshiya%3BOhnishi%2C+Takashi%3BLane%2C+Richard+D%3BMaeda%2C+Motonari%3BMori%2C+Takeyuki%3BNemoto%2C+Kiyotaka%3BMatsuda%2C+Hiroshi%3BKomaki%2C+Gen&rft.aulast=Moriguchi&rft.aufirst=Yoshiya&rft.date=2006-09-01&rft.volume=32&rft.issue=3&rft.spage=1472&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.04.186 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Emotions; Functional magnetic resonance imaging; Self; Inventories; Brain DO - http://dx.doi.org/10.1016/j.neuroimage.2006.04.186 ER - TY - JOUR T1 - Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain AN - 19458761; 7055708 AB - Neural progenitor cells (NPCs) reside within the subventricular zone (SVZ) in rodents. These NPCs give rise to neural precursors in adults that migrate to the olfactory bulb (OB) along a well-defined pathway, the rostral migratory stream (RMS). Here we demonstrate that these NPCs can be labeled, in vivo, in adult rats with fluorescent, micron-sized iron oxide particles (MPIOs), and that magnetic resonance imaging (MRI) can detect migrating neural precursors carrying MPIOs along the RMS to the OB. Immunohistochemistry and electron microscopy indicated that particles were inside GFAP super(+) neural progenitor cells in the SVZ, migrating PSA-NCAM super(+) and Doublecortin super(+) neural precursors within the RMS and OB, and Neu-N super(+) mature neurons in the OB. This work demonstrates that in vivo cell labeling of progenitor cells for MRI is possible and enables the serial, non-invasive visualization of endogenous progenitor/precursor cell migration. JF - NeuroImage AU - Shapiro, Erik M AU - Gonzalez-Perez, Oscar AU - Garcia-Verdugo, Jose Manuel AU - Alvarez-Buylla, Arturo AU - Koretsky, Alan P AD - Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA, erik.shapiro@yale.edu Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1150 EP - 1157 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - iron oxides KW - subventricular zone KW - Magnetic resonance imaging KW - Glial fibrillary acidic protein KW - Brain KW - Olfactory bulb KW - Neurons KW - Cell migration KW - Immunohistochemistry KW - Neural stem cells KW - Electron microscopy KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458761?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Magnetic+resonance+imaging+of+the+migration+of+neuronal+precursors+generated+in+the+adult+rodent+brain&rft.au=Shapiro%2C+Erik+M%3BGonzalez-Perez%2C+Oscar%3BGarcia-Verdugo%2C+Jose+Manuel%3BAlvarez-Buylla%2C+Arturo%3BKoretsky%2C+Alan+P&rft.aulast=Shapiro&rft.aufirst=Erik&rft.date=2006-09-01&rft.volume=32&rft.issue=3&rft.spage=1150&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.04.219 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Neural stem cells; Cell migration; Magnetic resonance imaging; Neurons; Brain; subventricular zone; Immunohistochemistry; Olfactory bulb; Electron microscopy; iron oxides; Glial fibrillary acidic protein DO - http://dx.doi.org/10.1016/j.neuroimage.2006.04.219 ER - TY - JOUR T1 - In Vivo Bone Formation by Human Bone Marrow Stromal Cells: Reconstruction of the Mouse Calvarium and Mandible AN - 19458178; 7065603 AB - Bone marrow stromal cells (BMSCs) contain a subset of multipotent cells with the potential to repair hard-tissue defects. Mouse BMSCs, combined with a collagen carrier, can close critical-sized homologous mouse calvarial defects, but this new bone has a poor union with the adjacent calvarium. When human BMSCs are transplanted for the purpose of engineering new bone, best results can be achieved if the cells are combined with hydroxyapatite/tricalcium phosphate (HA/TCP) particles. Here, we demonstrate that transplantation of cultured human BMSCs in conjunction with HA/TCP particles can be used successfully to close mouse craniofacial bone defects and that removal of the periosteum from the calvarium significantly enhances union with the transplant. Transplants were followed for up to 96 weeks and were found to change in morphology but not bone content after 8 weeks; this constitutes the first description of human BMSCs placed long-term to heal bone defects. New bone formation continued to occur in the oldest transplants, confirmed by tetracycline labeling. Additionally, the elastic modulus of this engineered bone resembled that of the normal mouse calvarium, and our use of atomic force microscopy (AFM)-based nanoindentation offered us the first opportunity to compare these small transplants against equally minute mouse bones. Our results provide insights into the long-term behavior of newly engineered orthotopic bone from human cells and have powerful implications for therapeutic human BMSC transplantation. JF - Stem Cells AU - Mankani, Mahesh H AU - Kuznetsov, Sergei A AU - Wolfe, Raymond M AU - Marshall, Grayson W AU - Robey, Pamela Gehron AD - Division of Plastic Surgery, Department of Surgery, University of California-San Francisco, San Francisco, California, USA. Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Preventive and Restorative Dental Sciences, University of California San Francisco, San Francisco, California, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 2140 EP - 2149 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 9 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts KW - Reconstruction KW - stromal cells KW - atomic force microscopy KW - Bone marrow KW - Tetracyclines KW - Collagen KW - Mandible KW - Hydroxyapatite KW - Stem cells KW - Periosteum KW - tricalcium phosphate KW - Osteogenesis KW - Mechanical properties KW - W 30905:Medical Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458178?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=In+Vivo+Bone+Formation+by+Human+Bone+Marrow+Stromal+Cells%3A+Reconstruction+of+the+Mouse+Calvarium+and+Mandible&rft.au=Mankani%2C+Mahesh+H%3BKuznetsov%2C+Sergei+A%3BWolfe%2C+Raymond+M%3BMarshall%2C+Grayson+W%3BRobey%2C+Pamela+Gehron&rft.aulast=Mankani&rft.aufirst=Mahesh&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=2140&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - stromal cells; Bone marrow; Mechanical properties; Osteogenesis; Stem cells; Collagen; tricalcium phosphate; atomic force microscopy; Hydroxyapatite; Tetracyclines; Periosteum; Reconstruction; Mandible ER - TY - JOUR T1 - Wilson's disease: cranial MRI observations and clinical correlation AN - 19439493; 7088144 AB - Introduction Study of MRI changes may be useful in diagnosis, prognosis and better understanding of the pathophysiology of Wilson's disease (WD). We aimed to describe and correlate the MRI abnormalities of the brain with clinical features in WD. Methods MRI evaluation was carried out in 100 patients (57 males, 43 females; mean age 19.3 plus or minus 8.9 years) using standard protocols. All but 18 patients were on de-coppering agents. Their history, clinical manifestations and scores for severity of disease were noted. Results The mean duration of illness and treatment were 8.3 plus or minus 10.8 years and 7.5 plus or minus 7.1 years respectively. MRI of the brain was abnormal in all the 93 symptomatic patients. The most conspicuous observations were atrophy of the cerebrum (70%), brainstem (66%) and cerebellum (52%). Signal abnormalities were also noted: putamen (72%), caudate (61%), thalami (58%), midbrain (49%), pons (20%), cerebral white matter (25%), cortex (9%), medulla (12%) and cerebellum (10%). The characteristic T2-W globus pallidal hypointensity (34%), "Face of giant panda" sign (12%), T1-W striatal hyperintensity (6%), central pontine myelinosis (7%), and bright claustral sign (4%) were also detected. MRI changes correlated with disease severity scores (P<0.001) but did not correlate with the duration of illness. Conclusion MRI changes were universal but diverse and involved almost all the structures of the brain in symptomatic patients. A fair correlation between MRI observations and various clinical features provides an explanation for the protean manifestations of the disease. JF - Neuroradiology AU - Sinha, S AU - Taly, AB AU - Ravishankar, S AU - Prashanth, L K AU - Venugopal, K S AU - Arunodaya, G R AU - Vasudev, M K AU - Swamy, H S AD - Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Hosur road, Banqalore, 560029, India, sanjib_sinha@nimhans.kar.nic.in Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 613 EP - 621 VL - 48 IS - 9 SN - 0028-3940, 0028-3940 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Cerebrum KW - Magnetic resonance imaging KW - Cerebellum KW - Substantia alba KW - Putamen KW - Mesencephalon KW - Cortex KW - Medulla oblongata KW - Skull KW - Neostriatum KW - Brain stem KW - Prognosis KW - Brain KW - Wilson's disease KW - Atrophy KW - Pons KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439493?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroradiology&rft.atitle=Wilson%27s+disease%3A+cranial+MRI+observations+and+clinical+correlation&rft.au=Sinha%2C+S%3BTaly%2C+AB%3BRavishankar%2C+S%3BPrashanth%2C+L+K%3BVenugopal%2C+K+S%3BArunodaya%2C+G+R%3BVasudev%2C+M+K%3BSwamy%2C+H+S&rft.aulast=Sinha&rft.aufirst=S&rft.date=2006-09-01&rft.volume=48&rft.issue=9&rft.spage=613&rft.isbn=&rft.btitle=&rft.title=Neuroradiology&rft.issn=00283940&rft_id=info:doi/10.1007%2Fs00234-006-0101-4 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Magnetic resonance imaging; Brain; Wilson's disease; Cerebellum; Skull; Substantia alba; Brain stem; Neostriatum; Putamen; Mesencephalon; Cerebrum; Medulla oblongata; Cortex; Prognosis; Atrophy; Pons DO - http://dx.doi.org/10.1007/s00234-006-0101-4 ER - TY - JOUR T1 - Autophagy-mediated reentry of Francisella tularensis into the endocytic compartment after cytoplasmic replication AN - 19363427; 7126144 AB - Intracellular bacterial pathogens evade the bactericidal functions of mammalian cells by physical escape from their phagosome and replication into the cytoplasm or through the modulation of phagosome maturation and biogenesis of a membrane-bound replicative organelle. Here, we detail in murine primary macrophages the intracellular life cycle of Francisella tularensis, a highly infectious bacterium that survives and replicates within mammalian cells. After transient interactions with the endocytic pathway, bacteria escaped from their phagosome by 1 h after infection and underwent replication in the cytoplasm from 4 to 20 h after infection. Unexpectedly, the majority of bacteria were subsequently found to be enclosed within large, juxtanuclear, LAMP-1-positive vacuoles called Francisella-containing vacuoles (FCVs). FCV formation required intracytoplasmic replication of bacteria. Using electron and fluorescence microscopy, we observed that the FCVs contained morphologically intact bacteria, despite fusing with lysosomes. FCVs are multimembranous structures that accumulate monodansylcadaverine and display the autophagy-specific protein LC3 on their membrane. Formation of FCVs was significantly inhibited by 3-methyladenine, confirming a role for the autophagic pathway in the biogenesis of these organelles. Taken together, our results demonstrate that, via autophagy, F. tularensis reenters the endocytic pathway after cytoplasmic replication, a process thus far undescribed for intracellular pathogens. JF - Proceedings of the National Academy of Sciences, USA AU - Checroun, Claire AU - Wehrly, Tara D AU - Fischer, Elizabeth R AU - Hayes, Stanley F AU - Celli, Jean AD - Tularemia Pathogenesis Section, Laboratory of Intracellular Parasites, and Microscopy Core Unit, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 14578 EP - 14583 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 39 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Fluorescence KW - Replication KW - Phagosomes KW - Life cycle KW - Francisella tularensis KW - Pathogens KW - Infection KW - Mammalian cells KW - Cytoplasm KW - Vacuoles KW - Organelles KW - Lysosomes KW - Evolution KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19363427?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Autophagy-mediated+reentry+of+Francisella+tularensis+into+the+endocytic+compartment+after+cytoplasmic+replication&rft.au=Checroun%2C+Claire%3BWehrly%2C+Tara+D%3BFischer%2C+Elizabeth+R%3BHayes%2C+Stanley+F%3BCelli%2C+Jean&rft.aulast=Checroun&rft.aufirst=Claire&rft.date=2006-09-01&rft.volume=103&rft.issue=39&rft.spage=14578&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Fluorescence; Replication; Phagosomes; Life cycle; Pathogens; Infection; Mammalian cells; Cytoplasm; Vacuoles; Organelles; Evolution; Lysosomes; Francisella tularensis ER - TY - JOUR T1 - Nucleotide Binding Oligomerization Domain 2 Deficiency Leads to Dysregulated TLR2 Signaling and Induction of Antigen-Specific Colitis AN - 19341208; 7071507 AB - In this study, we determined conditions leading to the development of colitis in mice with nucleotide binding oligomerization domain 2 (NOD2) deficiency, a susceptibility factor in Crohns disease. We found that NOD2- deficient antigen-presenting cells (APCs) produced increased amounts of interleukin (IL)-12 in the presence of ovalbumin (OVA) peptide and peptidoglycan or recombinant E. coli that express OVA peptide (ECOVA). Furthermore, these APCs elicited heightened interferon- gamma (IFN- gamma ) responses from cocultured OVA- specific CD4 super(+) T cells. We then demonstrated that NOD2-deficient mice adoptively transferred OVA-specific CD4 super(+) T cells and that administered intrarectal ECOVA developed colitis associated with the expansion of OVA- specific CD4 super(+) T cells producing IFN- gamma . Importantly, this colitis was highly dependent on Toll-like receptor 2 (TLR2) function since it was suppressed in NOD2 and TLR2 double-deficient mice. Thus, NOD2-deficient mice become susceptible to colitis as a result of increased TLR2 responses when they have the capacity to respond to an antigen expressed by mucosal bacteria. JF - Immunity AU - Watanabe, Tomohiro AU - Kitani, Atsushi AU - Murray, Peter J AU - Wakatsuki, Yoshio AU - Fuss, Ivan J AU - Strober, Warren AD - Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10-CRC, Room 5W3940, 10 Center Drive, Bethesda, Maryland 20892, wstrober@niaid.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 473 EP - 485 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 25 IS - 3 SN - 1074-7613, 1074-7613 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - SIGNALING KW - MOLIMMUNO KW - HUMDISEASE KW - Ovalbumin KW - gamma -Interferon KW - NOD2 protein KW - Oligomerization KW - TLR2 protein KW - Interleukins KW - peptidoglycans KW - Nucleotides KW - CD4 antigen KW - Risk factors KW - Escherichia coli KW - Lymphocytes T KW - Antigen-presenting cells KW - Colitis KW - Toll-like receptors KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19341208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Immunity&rft.atitle=Nucleotide+Binding+Oligomerization+Domain+2+Deficiency+Leads+to+Dysregulated+TLR2+Signaling+and+Induction+of+Antigen-Specific+Colitis&rft.au=Watanabe%2C+Tomohiro%3BKitani%2C+Atsushi%3BMurray%2C+Peter+J%3BWakatsuki%2C+Yoshio%3BFuss%2C+Ivan+J%3BStrober%2C+Warren&rft.aulast=Watanabe&rft.aufirst=Tomohiro&rft.date=2006-09-01&rft.volume=25&rft.issue=3&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Immunity&rft.issn=10747613&rft_id=info:doi/10.1016%2Fj.immuni.2006.06.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - gamma -Interferon; Ovalbumin; NOD2 protein; TLR2 protein; Oligomerization; Interleukins; peptidoglycans; Nucleotides; CD4 antigen; Risk factors; Lymphocytes T; Antigen-presenting cells; Colitis; Toll-like receptors; Signal transduction; Escherichia coli DO - http://dx.doi.org/10.1016/j.immuni.2006.06.018 ER - TY - JOUR T1 - Disposition of 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE153) and its interaction with other polybrominated diphenyl ethers (PBDEs) in rodents AN - 19339358; 7085997 AB - The disposition of the super(14)C-labelled polybrominated diphenyl ether (PBDE) 2,2',4,4',5,5'-hexaBDE (BDE153) was investigated in rodents following single and multiple doses and in a mixture with radiolabelled 2,2',4,4'-tetraBDE (BDE47) and 2,2',4,4',5-pentaBDE (BDE99). In single exposure studies there was little or no effect of dose on BDE153 disposition in male rats in the range 1-100 mu mol kg super(-1). No major sex or species differences in the in vivo fate of BDE153 were detected. BDE153 was absorbed in rats or mice following gavage by approximately 70%; retained in tissues; and poorly metabolized and slowly excreted. Mixture studies indicated that, relative to each other, more BDE47 was distributed to adipose tissue, more BDE153 accumulated in the liver, and BDE99 was metabolized to the greatest extent. BDE153 was probably retained in the liver due to minimal metabolism and elimination after `first-pass' distribution to the tissue following gavage. JF - Xenobiotica AU - Sanders, J M AU - Lebetkin, E H AU - Chen, L-J AU - Burka, L T AD - Laboratory of Pharmacology and Chemistry, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 824 EP - 837 VL - 36 IS - 9 SN - 0049-8254, 0049-8254 KW - Toxicology Abstracts KW - polybrominated diphenyl ethers KW - Liver KW - Adipose tissue KW - Disposition KW - Ethers KW - Metabolism KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19339358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Xenobiotica&rft.atitle=Disposition+of+2%2C2%27%2C4%2C4%27%2C5%2C5%27-hexabromodiphenyl+ether+%28BDE153%29+and+its+interaction+with+other+polybrominated+diphenyl+ethers+%28PBDEs%29+in+rodents&rft.au=Sanders%2C+J+M%3BLebetkin%2C+E+H%3BChen%2C+L-J%3BBurka%2C+L+T&rft.aulast=Sanders&rft.aufirst=J&rft.date=2006-09-01&rft.volume=36&rft.issue=9&rft.spage=824&rft.isbn=&rft.btitle=&rft.title=Xenobiotica&rft.issn=00498254&rft_id=info:doi/10.1080%2F00498250600815906 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - polybrominated diphenyl ethers; Liver; Adipose tissue; Disposition; Ethers; Metabolism DO - http://dx.doi.org/10.1080/00498250600815906 ER - TY - JOUR T1 - Inactivation of Rv2525c, a Substrate of the Twin Arginine Translocation (Tat) System of Mycobacterium tuberculosis, Increases beta -Lactam Susceptibility and Virulence AN - 19327991; 7061535 AB - The twin arginine translocation (Tat) system is used by many bacteria to export fully folded proteins containing cofactors. Here, we show genetically that this system is essential for Mycobacterium tuberculosis, as the tatAC operon and tatB genes could be inactivated only in partially diploid strains. Using comparative genomics, the rv2525c gene of M. tuberculosis was identified as encoding a histidine-rich protein, with a twin arginine signal peptide, and orthologous genes were shown to be present in several but not all actinobacterial species. Conservation of this gene by Mycobacterium leprae, which has undergone reductive evolution, suggested an important role for rv2525c. An rv2525c knockout mutant was constructed, and biochemical analysis indicated that the mature Rv2525c protein is secreted. Upon exposure to antituberculous drugs, rv2525c expression is significantly up-regulated together with those of other genes involved in cell wall biogenesis. Phenotypic comparison of the mutant with the parental strain revealed an increase in susceptibility to some beta -lactam antibiotics and, despite slower growth in vitro, enhanced virulence in both cellular and murine models of tuberculosis. The Tat system thus contributes in multiple ways to survival of the tubercle bacillus. JF - Journal of Bacteriology AU - Saint-Joanis, Brigitte AU - Demangel, Caroline AU - Jackson, Mary AU - Brodin, Priscille AU - Marsollier, Laurent AU - Boshoff, Helena AU - Cole, Stewart T AD - Unite de Genetique Moleculaire Bacterienne. Unite de Genetique Mycobacterienne, Institut Pasteur, Paris, France. Tuberculosis Research Section, NIAID, National Institutes of Health, 12441 Parklawn Drive, Rockville, Maryland 20852 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 6669 EP - 6679 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 18 SN - 0021-9193, 0021-9193 KW - Microbiology Abstracts B: Bacteriology KW - Diploids KW - Arginine KW - Mycobacterium leprae KW - Signal peptides KW - Animal models KW - Biochemical analysis KW - Virulence KW - Twins KW - Cofactors KW - beta -Lactam antibiotics KW - Tuberculosis KW - Evolutionary genetics KW - genomics KW - Operons KW - Bacillus KW - Translocation KW - Drugs KW - Mycobacterium tuberculosis KW - Cell walls KW - J 02340:Antibiotics & Antimicrobials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19327991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Inactivation+of+Rv2525c%2C+a+Substrate+of+the+Twin+Arginine+Translocation+%28Tat%29+System+of+Mycobacterium+tuberculosis%2C+Increases+beta+-Lactam+Susceptibility+and+Virulence&rft.au=Saint-Joanis%2C+Brigitte%3BDemangel%2C+Caroline%3BJackson%2C+Mary%3BBrodin%2C+Priscille%3BMarsollier%2C+Laurent%3BBoshoff%2C+Helena%3BCole%2C+Stewart+T&rft.aulast=Saint-Joanis&rft.aufirst=Brigitte&rft.date=2006-09-01&rft.volume=188&rft.issue=18&rft.spage=6669&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diploids; Arginine; Signal peptides; Animal models; Biochemical analysis; Virulence; Cofactors; Twins; beta -Lactam antibiotics; Tuberculosis; genomics; Evolutionary genetics; Operons; Drugs; Translocation; Cell walls; Mycobacterium leprae; Bacillus; Mycobacterium tuberculosis ER - TY - JOUR T1 - Maternal infection and white matter toxicity AN - 19326631; 7074634 AB - Studies examining maternal infection as a risk factor for neurological disorders in the offspring have suggested that altered maternal immune status during pregnancy can be considered as an adverse event in prenatal development. Infection occurring in the mother during the gestational period has been implicated in multiple neurological effects. The current manuscript will consider the issue of immune/inflammatory conditions during prenatal development where adverse outcomes have been linked to maternal systemic infection. The discussions will focus primary on white matter and oligodendrocytes as they have been identified as target processes. This white matter damage occurs in very early preterm infants and in various other human diseases currently being examined for a linkage to maternal or early developmental immune status. The intent is to draw attention to the impact of altered immune status during pregnancy on the offspring for the consideration of such contributing factors to the general assessment of developmental neurotoxicology. JF - Neurotoxicology AU - Harry, GJean AU - Lawler, Cindy AU - Brunssen, Susan H AD - Neurotoxicology Group, Laboratory of Neurobiology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA, harry@niehs.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 658 EP - 670 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 27 IS - 5 SN - 0161-813X, 0161-813X KW - CSA Neurosciences Abstracts; Toxicology Abstracts KW - Microglia KW - White matter damage KW - Inflammation KW - Oligodendrocyte KW - Immune status KW - Neurological diseases KW - Oligodendrocytes KW - Risk factors KW - Disseminated infection KW - Substantia alba KW - Progeny KW - Toxicity KW - Pregnancy KW - Infants KW - N3 11028:Neuropharmacology & toxicology KW - X 24490:Other UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19326631?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurotoxicology&rft.atitle=Maternal+infection+and+white+matter+toxicity&rft.au=Harry%2C+GJean%3BLawler%2C+Cindy%3BBrunssen%2C+Susan+H&rft.aulast=Harry&rft.aufirst=GJean&rft.date=2006-09-01&rft.volume=27&rft.issue=5&rft.spage=658&rft.isbn=&rft.btitle=&rft.title=Neurotoxicology&rft.issn=0161813X&rft_id=info:doi/10.1016%2Fj.neuro.2006.05.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Immune status; Neurological diseases; Oligodendrocytes; Risk factors; Disseminated infection; Substantia alba; Progeny; Toxicity; Infants; Inflammation; Pregnancy DO - http://dx.doi.org/10.1016/j.neuro.2006.05.004 ER - TY - JOUR T1 - Integrins Are Markers of Human Neural Stem Cells AN - 19324730; 7065597 AB - The identification of markers for the isolation of human neural stem cells (hNSCs) is essential for studies of their biology and therapeutic applications. This study investigated expression of the integrin receptor family by hNSCs as potential markers. Selection of alpha 6 super(hi) or beta 1 super(hi) cells by fluorescence-activated cell sorting led to an enrichment of human neural precursors, as shown by both neurosphere forming assays and increased expression of prominin-1, sox2, sox3, nestin, bmi1, and musashi1 in the beta 1 super(hi) population. Cells expressing high levels of beta 1 integrin also expressed prominin-1 (CD133), a marker previously used to isolate hNSCs, and selection using integrin beta 1 super(hi) cells or prominin-1 super(hi) cells was found to be equally effective at enriching for hNSCs from neurospheres. Therefore, integrin subunits alpha 6 and beta 1 are highly expressed by human neural precursors and represent convenient markers for their prospective isolation. JF - Stem Cells AU - Hall, Peter E AU - Lathia, Justin D AU - Miller, Nigel GA AU - Caldwell, Maeve A AU - Ffrench-Constant, Charles AD - Department of Pathology and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom. Laboratory of Neurosciences, National Institute on Aging, Baltimore, Maryland, USA Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 2078 EP - 2084 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 9 SN - 1066-5099, 1066-5099 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Therapeutic applications KW - Flow cytometry KW - Stem cells KW - Integrins KW - Nestin KW - Purification KW - neurospheres KW - Neural stem cells KW - W 30905:Medical Applications KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19324730?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Integrins+Are+Markers+of+Human+Neural+Stem+Cells&rft.au=Hall%2C+Peter+E%3BLathia%2C+Justin+D%3BMiller%2C+Nigel+GA%3BCaldwell%2C+Maeve+A%3BFfrench-Constant%2C+Charles&rft.aulast=Hall&rft.aufirst=Peter&rft.date=2006-09-01&rft.volume=24&rft.issue=9&rft.spage=2078&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Integrins; Neural stem cells; neurospheres; Flow cytometry; Nestin; Therapeutic applications; Purification; Stem cells ER - TY - JOUR T1 - Cholesterol glucosylation promotes immune evasion by Helicobacter pylori AN - 19316542; 7046411 AB - Helicobacter pylori infection causes gastric pathology such as ulcer and carcinoma. Because H. pylori is auxotrophic for cholesterol, we have explored the assimilation of cholesterol by H. pylori in infection. Here we show that H. pylori follows a cholesterol gradient and extracts the lipid from plasma membranes of epithelial cells for subsequent glucosylation. Excessive cholesterol promotes phagocytosis of H. pylori by antigen- presenting cells, such as macrophages and dendritic cells, and enhances antigen- specific T cell responses. A cholesterol-rich diet during bacterial challenge leads to T cell-dependent reduction of the H. pylori burden in the stomach. Intrinsic [alpha]-glucosylation of cholesterol abrogates phagocytosis of H. pylori and subsequent T cell activation. We identify the gene hp0421 as encoding the enzyme cholesterol-[alpha]-glucosyltransferase responsible for cholesterol glucosylation. Generation of knockout mutants lacking hp0421 corroborates the importance of cholesteryl glucosides for escaping phagocytosis, T cell activation and bacterial clearance in vivo. Thus, we propose a mechanism regulating the host-pathogen interaction whereby glucosylation of a lipid tips the scales towards immune evasion or response. JF - Nature Medicine AU - Wunder, Christian AU - Churin, Yuri AU - Winau, Florian AU - Warnecke, Dirk AU - Vieth, Michael AU - Lindner, Buko AU - Zaehringer, Ulrich AU - Mollenkopf, Hans-Joachim AU - Heinz, Ernst AU - Meyer, Thomas F AD - Department of Molecular Biology, Max Planck Institute for Infection Biology, Chariteplatz 1, 10117 Berlin, Germany., wunderc@mail.nih.gov Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 1030 EP - 1038 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 12 IS - 9 SN - 1078-8956, 1078-8956 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Helicobacter pylori KW - Lipids KW - Cholesterol KW - Infection KW - glucosides KW - Carcinoma KW - Dendritic cells KW - Ulcers KW - Host-pathogen interactions KW - Lymphocytes T KW - Phagocytosis KW - Stomach KW - F 06106:Bacteria KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19316542?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Cholesterol+glucosylation+promotes+immune+evasion+by+Helicobacter+pylori&rft.au=Wunder%2C+Christian%3BChurin%2C+Yuri%3BWinau%2C+Florian%3BWarnecke%2C+Dirk%3BVieth%2C+Michael%3BLindner%2C+Buko%3BZaehringer%2C+Ulrich%3BMollenkopf%2C+Hans-Joachim%3BHeinz%2C+Ernst%3BMeyer%2C+Thomas+F&rft.aulast=Wunder&rft.aufirst=Christian&rft.date=2006-09-01&rft.volume=12&rft.issue=9&rft.spage=1030&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1480 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Dendritic cells; Ulcers; Host-pathogen interactions; Lipids; Lymphocytes T; Cholesterol; glucosides; Infection; Phagocytosis; Stomach; Carcinoma; Helicobacter pylori DO - http://dx.doi.org/10.1038/nm1480 ER - TY - JOUR T1 - Serum Brain-Derived Neurotrophic Factor Concentrations in Lean and Overweight Children and Adolescents AN - 19315369; 7062272 AB - CONTEXT: Brain-derived neurotrophic factor (BDNF) and its receptor appear to be important components of the leptin-signaling cascade involved in energy homeostasis, and mice with BDNF or TrkB gene haploinsufficiency have excessive adiposity. Little is known about the relationship between adiposity and BDNF, particularly in children. OBJECTIVE: The objective of the study was to study the association of serum BDNF with measures of adiposity in children. Design/Setting/Patients: BDNF was determined by a sandwich-type ELISA after an overnight fast in convenience sample of 328 subjects, aged 3-19 yr enriched for extreme obesity. In 43, BDNF was also measured before, and again 1 h after, consuming a high-energy content (787 kcal) milkshake. MAIN OUTCOME MEASURES: Measures included associations between BDNF and measures of adiposity. RESULTS: There were no significant univariate associations between log BDNF and adiposity measured by body mass index (BMI), BMI-Z score, or fat mass. However, in an analysis of covariance accounting for age, sex, race, pubertal status, and platelet count, BDNF was lower in overweight children (mean plus or minus SD, 39.8 plus or minus 24.8 vs. 47.0 plus or minus 25.4 ng/dl, P = 0.03); in multiple regression analyses with log BDNF as the dependent variable, BMI (P = 0.03), BMI-Z (P = 0.01), and body fat (P < 0.02) were all negatively associated with BDNF once age, pubertal status, and platelet count were included in the model. Ingestion of a meal did not significantly alter serum BDNF 1 h later (P = 0.26). CONCLUSIONS: Serum BDNF is lower in extremely overweight children and adolescents than those of normal weight. It remains to be determined whether obese individuals with low serum BDNF for age and platelet count have mutations that alter BDNF function. JF - Journal of Clinical Endocrinology and Metabolism AU - El-Gharbawy, Areeg H AU - Adler-Wailes, Diane C AU - Mirch, Margaret C AU - Theim, Kelly R AU - Ranzenhofer, Lisa AU - Tanofsky-Kraff, Marian AU - Yanovski, Jack A AD - Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-1103 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 3548 EP - 3552 PB - Endocrine Society, 4350 East West Highway Suite 500 Bethesda MD 20814-4426 USA, [mailto:societyservices@endo-society.org], [URL:http://www.endo-society.org/] VL - 91 IS - 9 SN - 0021-972X, 0021-972X KW - Physical Education Index; CSA Neurosciences Abstracts KW - Measurement KW - Age KW - Animal subjects KW - Body mass KW - Body weight KW - Weight KW - Regression analysis KW - Races KW - Sex KW - Brain-derived neurotrophic factor KW - Obesity KW - Enzyme-linked immunosorbent assay KW - Adolescence KW - Multiple regression analysis KW - Patients KW - Children KW - TrkB receptors KW - Energy balance KW - Analysis KW - haploinsufficiency KW - Platelets KW - Adipose tissue KW - Body fat KW - Body mass index KW - Mutation KW - N3 11009:Neuroendocrinology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19315369?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.atitle=Serum+Brain-Derived+Neurotrophic+Factor+Concentrations+in+Lean+and+Overweight+Children+and+Adolescents&rft.au=El-Gharbawy%2C+Areeg+H%3BAdler-Wailes%2C+Diane+C%3BMirch%2C+Margaret+C%3BTheim%2C+Kelly+R%3BRanzenhofer%2C+Lisa%3BTanofsky-Kraff%2C+Marian%3BYanovski%2C+Jack+A&rft.aulast=El-Gharbawy&rft.aufirst=Areeg&rft.date=2006-09-01&rft.volume=91&rft.issue=9&rft.spage=3548&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Endocrinology+and+Metabolism&rft.issn=0021972X&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Obesity; Age; Weight; Body mass; Animal subjects; Analysis; Adolescence; Patients; Children; Sex; Brain-derived neurotrophic factor; Enzyme-linked immunosorbent assay; Multiple regression analysis; TrkB receptors; Body weight; Energy balance; haploinsufficiency; Regression analysis; Platelets; Body fat; Adipose tissue; Body mass index; Mutation; Races ER - TY - JOUR T1 - Anthrax Lethal Toxin Impairs Innate Immune Functions of Alveolar Macrophages and Facilitates Bacillus anthracis Survival AN - 19313197; 7060654 AB - Alveolar macrophages (AM) are very important for pulmonary innate immune responses against invading inhaled pathogens because they directly kill the organisms and initiate a cascade of innate and adaptive immune responses. Although several factors contribute to inhalational anthrax, we hypothesized that unimpeded infection of Bacillus anthracis is directly linked to disabling the innate immune functions contributed by AM. Here, we investigated the effects of lethal toxin (LT), one of the binary complex virulence factors produced by B. anthracis, on freshly isolated nonhuman primate AM. Exposure of AM to doses of LT that killed susceptible macrophages had no effect on the viability of AM, despite complete MEK1 cleavage. Intoxicated AM remained fully capable of B. anthracis spore phagocytosis. However, pretreatment of AM with LT resulted in a significant decrease in the clearance of both the Sterne strain and the fully virulent Ames strain of B. anthracis, which may have been a result of impaired AM secretion of proinflammatory cytokines. Our data imply that cytolysis does not correlate with MEK1 cleavage, and this is the first report of LT-mediated impairment of nonhuman primate AM bactericidal activity against B. anthracis. JF - Infection and Immunity AU - Ribot, Wilson J AU - Panchal, Rekha G AU - Brittingham, Katherine C AU - Ruthel, Gordon AU - Kenny, Tara A AU - Lane, Douglas AU - Curry, Bob AU - Hoover, Timothy A AU - Friedlander, Arthur M AU - Bavari, Sina AD - U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702. Target Structure-Based Drug Discovery Group, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702-1201 Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 5029 EP - 5034 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 9 SN - 0019-9567, 0019-9567 KW - Primates KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Cell survival KW - Macrophages KW - Anthrax lethal toxin KW - Data processing KW - virulence factors KW - Pathogens KW - Bacillus anthracis KW - Infection KW - Alveoli KW - Inflammation KW - Lung KW - Cytolysis KW - Anthrax KW - Cytokines KW - Immune response KW - Spores KW - Phagocytosis KW - Bactericidal activity KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19313197?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Anthrax+Lethal+Toxin+Impairs+Innate+Immune+Functions+of+Alveolar+Macrophages+and+Facilitates+Bacillus+anthracis+Survival&rft.au=Ribot%2C+Wilson+J%3BPanchal%2C+Rekha+G%3BBrittingham%2C+Katherine+C%3BRuthel%2C+Gordon%3BKenny%2C+Tara+A%3BLane%2C+Douglas%3BCurry%2C+Bob%3BHoover%2C+Timothy+A%3BFriedlander%2C+Arthur+M%3BBavari%2C+Sina&rft.aulast=Ribot&rft.aufirst=Wilson&rft.date=2006-09-01&rft.volume=74&rft.issue=9&rft.spage=5029&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Cell survival; Anthrax lethal toxin; Data processing; virulence factors; Pathogens; Infection; Alveoli; Inflammation; Lung; Cytolysis; Cytokines; Anthrax; Immune response; Phagocytosis; Spores; Bactericidal activity; Bacillus anthracis; Primates ER - TY - JOUR T1 - Yersinia pestis YopJ Suppresses Tumor Necrosis Factor Alpha Induction and Contributes to Apoptosis of Immune Cells in the Lymph Node but Is Not Required for Virulence in a Rat Model of Bubonic Plague AN - 19305926; 7060670 AB - The virulence of the pathogenic Yersinia species depends on a plasmid-encoded type III secretion system that transfers six Yop effector proteins into host cells. One of these proteins, YopJ, has been shown to disrupt host cell signaling pathways involved in proinflammatory cytokine production and to induce macrophage apoptosis in vitro. YopJ-dependent apoptosis in mesenteric lymph nodes has also been demonstrated in a mouse model of Yersinia pseudotuberculosis infection. These results suggest that YopJ attenuates the host innate and adaptive immune response during infection, but the role of YopJ during bubonic plague has not been completely established. We evaluated the role of Yersinia pestis YopJ in a rat model of bubonic plague following intradermal infection with a fully virulent Y. pestis strain and an isogenic yopJ mutant. Deletion of yopJ resulted in a twofold decrease in the number of apoptotic immune cells in the bubo and a threefold increase in serum tumor necrosis factor alpha levels but did not result in decreased virulence, systemic spread, or colonization levels in the spleen and blood. Our results indicate that YopJ is not essential for bubonic plague pathogenesis, even after peripheral inoculation of low doses of Y. pestis. Instead, the effects of YopJ appear to overlap and augment the immunomodulatory effects of other Y. pestis virulence factors. JF - Infection and Immunity AU - Lemaitre, Nadine AU - Sebbane, Florent AU - Long, Daniel AU - Joseph Hinnebusch, B AD - Laboratory of Zoonotic Pathogens. Veterinary Branch. Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, Inserm U801, Lille F-50921, Universite de Lille II, Faculte de Medecine Henri Warembourg, Lille F-59045, Institut Pasteur de Lille, Lille F-59021, France Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 5126 EP - 5131 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 9 SN - 0019-9567, 0019-9567 KW - Eagle owls KW - Horned owls KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Clonal deletion KW - Apoptosis KW - virulence factors KW - Animal models KW - Bubo KW - Yersinia pestis KW - Yersinia pseudotuberculosis KW - Spleen KW - Infection KW - Lymph nodes KW - Inflammation KW - Colonization KW - Blood KW - Inoculation KW - Cytokines KW - Immune response KW - Tumor necrosis factor- alpha KW - Plague KW - Pseudotuberculosis KW - Signal transduction KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19305926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Yersinia+pestis+YopJ+Suppresses+Tumor+Necrosis+Factor+Alpha+Induction+and+Contributes+to+Apoptosis+of+Immune+Cells+in+the+Lymph+Node+but+Is+Not+Required+for+Virulence+in+a+Rat+Model+of+Bubonic+Plague&rft.au=Lemaitre%2C+Nadine%3BSebbane%2C+Florent%3BLong%2C+Daniel%3BJoseph+Hinnebusch%2C+B&rft.aulast=Lemaitre&rft.aufirst=Nadine&rft.date=2006-09-01&rft.volume=74&rft.issue=9&rft.spage=5126&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Apoptosis; Clonal deletion; virulence factors; Animal models; Spleen; Infection; Lymph nodes; Inflammation; Blood; Colonization; Inoculation; Cytokines; Plague; Tumor necrosis factor- alpha; Immune response; Pseudotuberculosis; Signal transduction; Yersinia pseudotuberculosis; Yersinia pestis; Bubo ER - TY - JOUR T1 - OC100: The combined use of uterine artery Doppler and maternal plasma placental growth factor concentrations identifies patients at risk for early onset and/or severe pre-eclampsia AN - 19284991; 8633340 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Espinoza, J AU - Nien, J K AU - Kusanovic, J P AU - Goncalves, L F AU - Medina, L AU - Gomez, R AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 387 EP - 388 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Uterus KW - Gynecology KW - Placenta KW - Arteries KW - Pre-eclampsia KW - Growth factors KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19284991?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC100%3A+The+combined+use+of+uterine+artery+Doppler+and+maternal+plasma+placental+growth+factor+concentrations+identifies+patients+at+risk+for+early+onset+and%2For+severe+pre-eclampsia&rft.au=Espinoza%2C+J%3BNien%2C+J+K%3BKusanovic%2C+J+P%3BGoncalves%2C+L+F%3BMedina%2C+L%3BGomez%2C+R%3BRomero%2C+R&rft.aulast=Espinoza&rft.aufirst=J&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=387&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.2960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Growth factors; Pre-eclampsia; Arteries; Uterus; Gynecology; Ultrasound; Placenta DO - http://dx.doi.org/10.1002/uog.2960 ER - TY - JOUR T1 - OC169: Asymptomatic women with amniotic fluid sludge in the mid-trimester are at increased risk for spontaneous preterm delivery and intra-amniotic infection AN - 19282989; 8633409 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Espinoza, J AU - Goncalves, L F AU - Hassan, S AU - Soto, E AU - Nien, J K AU - Erez, O AU - Schoen, M L AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethseda, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 409 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Amniotic fluid KW - Gynecology KW - Sludges KW - Infection KW - Ultrasound KW - Obstetrics KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19282989?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC169%3A+Asymptomatic+women+with+amniotic+fluid+sludge+in+the+mid-trimester+are+at+increased+risk+for+spontaneous+preterm+delivery+and+intra-amniotic+infection&rft.au=Kusanovic%2C+J+P%3BEspinoza%2C+J%3BGoncalves%2C+L+F%3BHassan%2C+S%3BSoto%2C+E%3BNien%2C+J+K%3BErez%2C+O%3BSchoen%2C+M+L%3BRomero%2C+R&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=409&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.3029 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Obstetrics; Infection; Amniotic fluid; Gynecology; Sludges; Ultrasound DO - http://dx.doi.org/10.1002/uog.3029 ER - TY - JOUR T1 - OC34: Lung volume measurements by 3D ultrasound are not superior to biometry by 2D ultrasound to predict pulmonary hypoplasia in fetuses with musculoskeletal disorders AN - 19282710; 8633274 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Goncalves, L F AU - Kusanovic, J P AU - Espinoza, J AU - Lee, W AU - McNamee, N AU - Schoen, M L AU - Erez, O AU - Treadwell, M C AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 368 EP - 369 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Hypoplasia KW - Gynecology KW - Lung KW - Obstetrics KW - Ultrasound KW - Fetuses KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19282710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OC34%3A+Lung+volume+measurements+by+3D+ultrasound+are+not+superior+to+biometry+by+2D+ultrasound+to+predict+pulmonary+hypoplasia+in+fetuses+with+musculoskeletal+disorders&rft.au=Goncalves%2C+L+F%3BKusanovic%2C+J+P%3BEspinoza%2C+J%3BLee%2C+W%3BMcNamee%2C+N%3BSchoen%2C+M+L%3BErez%2C+O%3BTreadwell%2C+M+C%3BRomero%2C+R&rft.aulast=Goncalves&rft.aufirst=L&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=368&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.2894 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ultrasound; Lung; Obstetrics; Hypoplasia; Fetuses; Gynecology DO - http://dx.doi.org/10.1002/uog.2894 ER - TY - JOUR T1 - OP09.09: Volumetric measurements of the cervix by 3D ultrasonography do not improve the prediction of preterm delivery when compared to cervical length measured by 2D ultrasonography AN - 19274367; 8633632 AB - Abstract not available. JF - Ultrasound in Obstetrics and Gynecology AU - Kusanovic, J P AU - Goncalves, L F AU - Espinoza, J AU - Hassan, S AU - Soto, E AU - Erez, O AU - Folts, A AU - Romero, R AD - Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, United States; Detroit Medical Center, United States Y1 - 2006/09// PY - 2006 DA - Sep 2006 SP - 473 EP - 474 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 28 IS - 4 SN - 0960-7692, 0960-7692 KW - Biotechnology and Bioengineering Abstracts KW - Gynecology KW - Cervix KW - Ultrasound KW - Obstetrics KW - Ultrasonography KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19274367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Ultrasound+in+Obstetrics+and+Gynecology&rft.atitle=OP09.09%3A+Volumetric+measurements+of+the+cervix+by+3D+ultrasonography+do+not+improve+the+prediction+of+preterm+delivery+when+compared+to+cervical+length+measured+by+2D+ultrasonography&rft.au=Kusanovic%2C+J+P%3BGoncalves%2C+L+F%3BEspinoza%2C+J%3BHassan%2C+S%3BSoto%2C+E%3BErez%2C+O%3BFolts%2C+A%3BRomero%2C+R&rft.aulast=Kusanovic&rft.aufirst=J&rft.date=2006-09-01&rft.volume=28&rft.issue=4&rft.spage=473&rft.isbn=&rft.btitle=&rft.title=Ultrasound+in+Obstetrics+and+Gynecology&rft.issn=09607692&rft_id=info:doi/10.1002%2Fuog.3252 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-12-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Ultrasonography; Obstetrics; Cervix; Gynecology; Ultrasound DO - http://dx.doi.org/10.1002/uog.3252 ER - TY - JOUR T1 - Chimeric West Nile/dengue virus vaccine candidate: Preclinical evaluation in mice, geese and monkeys for safety and immunogenicity AN - 1500773737; 19046410 AB - A live attenuated virus vaccine is being developed to protect against West Nile virus (WN) disease in humans. Previously, it was found that chimeric West Nile/dengue viruses (WN/DEN4 and WN/DEN4 Delta 30) bearing the membrane precursor and envelope protein genes of WN on a backbone of dengue type 4 virus (DEN4) with or without a deletion of 30 nucleotides ( Delta 30) in the 3\' noncoding region of the DEN4 part of the chimeric genome were attenuated and efficacious in mice and monkeys against WN challenge. Here, we report the generation of a clinical lot of WN/DEN4 Delta 30 virus and its further preclinical evaluation for safety and immunogenicity in mice, geese and monkeys. The vaccine candidate had lost neuroinvasiveness in highly sensitive immunodeficient mice inoculated intraperitoneally and had greatly reduced neurovirulence in suckling mice inoculated intracerebrally (IC). Compared to the wild-type WN parent, the chimeric virus was highly restricted in replication in both murine and human neuroblastoma cells as well as in brains of suckling mice. The WN/DEN4 Delta 30 virus failed to infect geese, indicating that chimerization of WN with DEN4 completely attenuated WN for this avian host. This observation suggests that the WN/DEN4 chimeric viruses would be restricted in their ability to be transmitted from vaccinees to domestic or wild birds. In monkeys, the WN/DEN4 Delta 30 vaccine candidate was highly immunogenic despite its low level of replication with undetectable viremia. Furthermore, the WN/DEN4 Delta 30 vaccine virus was safe and readily induced neutralizing antibodies against WN in monkeys immune to each of the four serotypes of dengue virus. These studies confirm the attenuation of WN/DEN4 Delta 30 for non-human primates, including dengue-immune monkeys, and demonstrate both a highly restricted replication (>108-fold decrease) in the brain of mice inoculated IC and an absence of infectivity for birds, findings that indicate this vaccine should be safe for both the recipient and the environment. JF - Vaccine AU - Pletnev, Alexander G AU - Swayne, David E AU - Speicher, Jim AU - Rumyantsev, Alexander A AU - Murphy, Brian R AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8133, USA Y1 - 2006/09// PY - 2006 DA - September 2006 SP - 6392 EP - 6404 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 24 IS - 40 SN - 0264-410X, 0264-410X KW - ASFA 3: Aquatic Pollution & Environmental Quality; ASFA 1: Biological Sciences & Living Resources; Virology & AIDS Abstracts; Immunology Abstracts KW - West Nile virus KW - Live virus vaccine KW - Dengue virus KW - Genomes KW - Invasiveness KW - Human diseases KW - Serotypes KW - Viruses KW - Immunodeficiency KW - Disease control KW - Disease transmission KW - Public health KW - Gene deletion KW - Dengue KW - Envelope protein KW - Replication KW - Neurovirulence KW - Brain KW - Suckling behavior KW - Nucleotides KW - Antibodies KW - Infectivity KW - Immunogenicity KW - Neuroblastoma cells KW - Viremia KW - Vaccines KW - Aquatic birds KW - V 22350:Immunology KW - F 06905:Vaccines KW - Q1 08423:Behaviour KW - Q5 08524:Public health, medicines, dangerous organisms UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500773737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Chimeric+West+Nile%2Fdengue+virus+vaccine+candidate%3A+Preclinical+evaluation+in+mice%2C+geese+and+monkeys+for+safety+and+immunogenicity&rft.au=Pletnev%2C+Alexander+G%3BSwayne%2C+David+E%3BSpeicher%2C+Jim%3BRumyantsev%2C+Alexander+A%3BMurphy%2C+Brian+R&rft.aulast=Pletnev&rft.aufirst=Alexander&rft.date=2006-09-01&rft.volume=24&rft.issue=40&rft.spage=6392&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.06.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2016-12-22 N1 - SubjectsTermNotLitGenreText - Human diseases; Replication; Viruses; Brain; Disease control; Vaccines; Nucleotides; Aquatic birds; Public health; Genomes; Invasiveness; Serotypes; Immunodeficiency; Neurovirulence; Suckling behavior; Disease transmission; Infectivity; Antibodies; Gene deletion; Immunogenicity; Dengue; Envelope protein; Neuroblastoma cells; Viremia; Dengue virus; West Nile virus DO - http://dx.doi.org/10.1016/j.vaccine.2006.06.008 ER - TY - CPAPER T1 - Critical Design Considerations for Pediatric Circulatory Support Devices T2 - 14th Congress of International Society for Rotary Blood Pumps (ISRBP 2006) AN - 40241635; 4366930 JF - 14th Congress of International Society for Rotary Blood Pumps (ISRBP 2006) AU - Baldwin, T Y1 - 2006/08/31/ PY - 2006 DA - 2006 Aug 31 KW - Pediatrics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=14th+Congress+of+International+Society+for+Rotary+Blood+Pumps+%28ISRBP+2006%29&rft.atitle=Critical+Design+Considerations+for+Pediatric+Circulatory+Support+Devices&rft.au=Baldwin%2C+T&rft.aulast=Baldwin&rft.aufirst=T&rft.date=2006-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=14th+Congress+of+International+Society+for+Rotary+Blood+Pumps+%28ISRBP+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kuleuven.be/isrbp2006/docs/ProgramAbstractsFinal.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Stochastic Modeling of Tumor Induced Angiogenesis in a Heterogeneous Medium, the Extracellular Matrix T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2006) AN - 40166883; 4319177 JF - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2006) AU - Amyot, Franck AU - Gandjbakhche, Amir Y1 - 2006/08/31/ PY - 2006 DA - 2006 Aug 31 KW - Angiogenesis KW - Extracellular matrix KW - Tumors KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40166883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+International+Conference+of+the+IEEE+Engineering+in+Medicine+and+Biology+Society+%28IEEE+EMBC+2006%29&rft.atitle=Stochastic+Modeling+of+Tumor+Induced+Angiogenesis+in+a+Heterogeneous+Medium%2C+the+Extracellular+Matrix&rft.au=Amyot%2C+Franck%3BGandjbakhche%2C+Amir&rft.aulast=Amyot&rft.aufirst=Franck&rft.date=2006-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+International+Conference+of+the+IEEE+Engineering+in+Medicine+and+Biology+Society+%28IEEE+EMBC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://embs.papercept.net/conferences/conferences/EMBC06/program/EMBC0 6_ContentListWeb_2.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Neuroscientific Exploitation of High-Resolution Functional Magnetic Resonance Imaging T2 - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2006) AN - 40157766; 4318357 JF - 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC 2006) AU - Kriegeskorte, Nikolaus AU - Bandettini, Peter A Y1 - 2006/08/31/ PY - 2006 DA - 2006 Aug 31 KW - Functional magnetic resonance imaging KW - Imaging techniques KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40157766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=28th+Annual+International+Conference+of+the+IEEE+Engineering+in+Medicine+and+Biology+Society+%28IEEE+EMBC+2006%29&rft.atitle=The+Neuroscientific+Exploitation+of+High-Resolution+Functional+Magnetic+Resonance+Imaging&rft.au=Kriegeskorte%2C+Nikolaus%3BBandettini%2C+Peter+A&rft.aulast=Kriegeskorte&rft.aufirst=Nikolaus&rft.date=2006-08-31&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=28th+Annual+International+Conference+of+the+IEEE+Engineering+in+Medicine+and+Biology+Society+%28IEEE+EMBC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://embs.papercept.net/conferences/conferences/EMBC06/program/EMBC0 6_ContentListWeb_2.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Human Epidermal Growth Factor Receptor Type 2 (HER2) Targeted Spectral Fluorescence Molecular Imaging of Lung Metastases Using a Herceptin-Rhodamine Green Conjugate T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40200195; 4334094 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Koyama, Yoshinori AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Bernardo, Marcelino AU - Choyke, Peter AU - Kobayashi, Hisataka Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Lung KW - Fluorescence KW - Imaging techniques KW - ErbB-2 protein KW - Epidermal growth factor receptors KW - Metastases KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200195?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Human+Epidermal+Growth+Factor+Receptor+Type+2+%28HER2%29+Targeted+Spectral+Fluorescence+Molecular+Imaging+of+Lung+Metastases+Using+a+Herceptin-Rhodamine+Green+Conjugate&rft.au=Koyama%2C+Yoshinori%3BHama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter%3BKobayashi%2C+Hisataka&rft.aulast=Koyama&rft.aufirst=Yoshinori&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development and Validation of Metastatic Breast Cancer Model in the Nude Rat Using MRI and Bioluminescence Imaging (BLI) T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40200106; 4334072 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Song, Ho-Taek AU - Jordan, E Kay AU - Lewis, Bobbi K AU - Kaunberg, Brenda AU - Palmieri, Diane AU - Ventura, Juan AU - Elango, Chinnasamy AU - Lui, Wei AU - Frank, Joseph A Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Breast cancer KW - Magnetic resonance imaging KW - Animal models KW - Bioluminescence KW - Metastases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200106?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Development+and+Validation+of+Metastatic+Breast+Cancer+Model+in+the+Nude+Rat+Using+MRI+and+Bioluminescence+Imaging+%28BLI%29&rft.au=Song%2C+Ho-Taek%3BJordan%2C+E+Kay%3BLewis%2C+Bobbi+K%3BKaunberg%2C+Brenda%3BPalmieri%2C+Diane%3BVentura%2C+Juan%3BElango%2C+Chinnasamy%3BLui%2C+Wei%3BFrank%2C+Joseph+A&rft.aulast=Song&rft.aufirst=Ho-Taek&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DCE-MRI Evaluation of Polyamidoamine Dendrimer Nanoparticle Blood-Tumor-Barrier Permeability in the RG-2 Rodent Malignant Glioma Model T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40200092; 4334066 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Sarin, Hemant AU - Fung, Steve AU - Barrett, Tristan AU - Regino, Celeste AU - Lewis, Ryan AU - Gupta, Sandeep AU - Li, King AU - Butman, John Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Permeability KW - Glioma KW - Nanoparticles KW - Brain tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200092?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=DCE-MRI+Evaluation+of+Polyamidoamine+Dendrimer+Nanoparticle+Blood-Tumor-Barrier+Permeability+in+the+RG-2+Rodent+Malignant+Glioma+Model&rft.au=Sarin%2C+Hemant%3BFung%2C+Steve%3BBarrett%2C+Tristan%3BRegino%2C+Celeste%3BLewis%2C+Ryan%3BGupta%2C+Sandeep%3BLi%2C+King%3BButman%2C+John&rft.aulast=Sarin&rft.aufirst=Hemant&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Bioluminescent Imaging Studies: Pulsed High-Intensity Focused Ultrasound Enhances the Viral Gene Delivery in Tumor Models T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40196819; 4334076 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Sun, Haihao AU - Khaibullina, Alfia AU - Li, King Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Gene transfer KW - Imaging techniques KW - Models KW - Ultrasound KW - Tumors KW - Bioluminescence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40196819?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Bioluminescent+Imaging+Studies%3A+Pulsed+High-Intensity+Focused+Ultrasound+Enhances+the+Viral+Gene+Delivery+in+Tumor+Models&rft.au=Sun%2C+Haihao%3BKhaibullina%2C+Alfia%3BLi%2C+King&rft.aulast=Sun&rft.aufirst=Haihao&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Two-Color Optical Lymphangiography with Near Infrared Quantum Dots to Map Lymphatic Flows from the Breast and the Upper Extremity T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40196480; 4334047 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Kobayashi, Hisataka AU - Hama, Yukihiro AU - Koyama, Yoshinori AU - Urano, Yasuteru AU - Choyke, Peter Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Musculoskeletal system KW - Breast KW - Lymphangiography UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40196480?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Simultaneous+Two-Color+Optical+Lymphangiography+with+Near+Infrared+Quantum+Dots+to+Map+Lymphatic+Flows+from+the+Breast+and+the+Upper+Extremity&rft.au=Kobayashi%2C+Hisataka%3BHama%2C+Yukihiro%3BKoyama%2C+Yoshinori%3BUrano%2C+Yasuteru%3BChoyke%2C+Peter&rft.aulast=Kobayashi&rft.aufirst=Hisataka&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-Invasive Imaging Tissue Redox Status using MRI and Redox Sensitive Paramagnetic Contrast Agents: Applications for Tumor Imaging T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40195710; 4333788 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Hyodo, Fuminori AU - Matsumoto, Ken-ichiro AU - Matsumoto, Atsuko AU - James, Mithcell Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Magnetic resonance imaging KW - Contrast media KW - Redox reactions KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40195710?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Non-Invasive+Imaging+Tissue+Redox+Status+using+MRI+and+Redox+Sensitive+Paramagnetic+Contrast+Agents%3A+Applications+for+Tumor+Imaging&rft.au=Hyodo%2C+Fuminori%3BMatsumoto%2C+Ken-ichiro%3BMatsumoto%2C+Atsuko%3BJames%2C+Mithcell&rft.aulast=Hyodo&rft.aufirst=Fuminori&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Delivery of a Fluorescent Lipophilic Tracer using an MRI Iron Oxide Contrast Agent as a Vehicle T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40193644; 4333736 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Sumner, James AU - Conroy, Richard AU - Koretsky, Alan P Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Iron oxides KW - Tracers KW - Magnetic resonance imaging KW - Fluorescent indicators KW - Contrast media KW - Lipophilic UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193644?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Delivery+of+a+Fluorescent+Lipophilic+Tracer+using+an+MRI+Iron+Oxide+Contrast+Agent+as+a+Vehicle&rft.au=Sumner%2C+James%3BConroy%2C+Richard%3BKoretsky%2C+Alan+P&rft.aulast=Sumner&rft.aufirst=James&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Fast Imaging of Oxygen Distribution In Vivo by FT-EPR T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40193475; 4333847 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Subramanian, Sankaran AU - Devasahaayam, Nallathamby AU - Johnson, Calvin AU - Hyodo, Fuminori AU - Matsumoto, Shingo AU - Mitchell, James AU - Krishna, Murali Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Oxygen KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40193475?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Fast+Imaging+of+Oxygen+Distribution+In+Vivo+by+FT-EPR&rft.au=Subramanian%2C+Sankaran%3BDevasahaayam%2C+Nallathamby%3BJohnson%2C+Calvin%3BHyodo%2C+Fuminori%3BMatsumoto%2C+Shingo%3BMitchell%2C+James%3BKrishna%2C+Murali&rft.aulast=Subramanian&rft.aufirst=Sankaran&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Inter-Crystal Scatter Rejection Improves Resolution of Small Animal PET T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40189975; 4333970 DE: JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Seidel, Jurgen AU - Martiniova, Lucia AU - Green, Michael V AU - Choyke, Peter Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40189975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Inter-Crystal+Scatter+Rejection+Improves+Resolution+of+Small+Animal+PET&rft.au=Seidel%2C+Jurgen%3BMartiniova%2C+Lucia%3BGreen%2C+Michael+V%3BChoyke%2C+Peter&rft.aulast=Seidel&rft.aufirst=Jurgen&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Target-Specific Activatable Optical Probe Based on a Self-Quenched Avidin-Rhodamine Conjugate for In Vivo Molecular Imaging of Cancer T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40188564; 4333538 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Hama, Yukihiro AU - Urano, Yasuteru AU - Koyama, Yoshinori AU - Bernardo, Marcelino AU - Choyke, Peter AU - Kobayashi, Hisataka Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Cancer KW - Probes KW - Imaging techniques UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40188564?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=A+Target-Specific+Activatable+Optical+Probe+Based+on+a+Self-Quenched+Avidin-Rhodamine+Conjugate+for+In+Vivo+Molecular+Imaging+of+Cancer&rft.au=Hama%2C+Yukihiro%3BUrano%2C+Yasuteru%3BKoyama%2C+Yoshinori%3BBernardo%2C+Marcelino%3BChoyke%2C+Peter%3BKobayashi%2C+Hisataka&rft.aulast=Hama&rft.aufirst=Yukihiro&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Preclinical Evaluation of Ferumoxides-Protamine Sulfate-Labeled Human Peripheral Blood Progenitor Cells (PBPC) in Intracranial Glioma T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40188347; 4333916 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Anderson, Stasia AU - Zhang, Wei AU - Fellowes, Vicki AU - Fan, Yong AU - Carter, Charles AU - Arbab, Ali AU - Read, Elizabeth AU - Fine, Howard AU - Frank, Joseph Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Peripheral blood KW - Hemopoiesis KW - Glioma KW - Brain tumors KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40188347?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Preclinical+Evaluation+of+Ferumoxides-Protamine+Sulfate-Labeled+Human+Peripheral+Blood+Progenitor+Cells+%28PBPC%29+in+Intracranial+Glioma&rft.au=Anderson%2C+Stasia%3BZhang%2C+Wei%3BFellowes%2C+Vicki%3BFan%2C+Yong%3BCarter%2C+Charles%3BArbab%2C+Ali%3BRead%2C+Elizabeth%3BFine%2C+Howard%3BFrank%2C+Joseph&rft.aulast=Anderson&rft.aufirst=Stasia&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Proton Magnetic Resonance Spectroscopy Analysis of Intra-Abdominal Fat Burden T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40187795; 4334258 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Simpson, R.Mark AU - Munasinghe, Jeeva AU - Berrigan, David AU - Bailey, Michael AU - Walling, Brent Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Spectroscopy KW - Magnetic resonance spectroscopy KW - Resonance UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40187795?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Proton+Magnetic+Resonance+Spectroscopy+Analysis+of+Intra-Abdominal+Fat+Burden&rft.au=Simpson%2C+R.Mark%3BMunasinghe%2C+Jeeva%3BBerrigan%2C+David%3BBailey%2C+Michael%3BWalling%2C+Brent&rft.aulast=Simpson&rft.aufirst=R.Mark&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Simultaneous Imaging of Tumor Oxygenation, Interstitial Fluid Pressure, and Vascularization using Overhauser-Enhanced MRI T2 - 5th Annual Meeting of the Society for Molecular Imaging AN - 40187045; 4333894 JF - 5th Annual Meeting of the Society for Molecular Imaging AU - Matsumoto, Shingo AU - Citrin, Deborah AU - Hyodo, Fuminori AU - Subramanian, Sankaran AU - Mitchel, James B AU - Krishna, Murali C Y1 - 2006/08/30/ PY - 2006 DA - 2006 Aug 30 KW - Oxygenation KW - Magnetic resonance imaging KW - Vascularization KW - Pressure KW - Tumors KW - Interstitial environment UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40187045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.atitle=Simultaneous+Imaging+of+Tumor+Oxygenation%2C+Interstitial+Fluid+Pressure%2C+and+Vascularization+using+Overhauser-Enhanced+MRI&rft.au=Matsumoto%2C+Shingo%3BCitrin%2C+Deborah%3BHyodo%2C+Fuminori%3BSubramanian%2C+Sankaran%3BMitchel%2C+James+B%3BKrishna%2C+Murali+C&rft.aulast=Matsumoto&rft.aufirst=Shingo&rft.date=2006-08-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Annual+Meeting+of+the+Society+for+Molecular+Imaging&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/browseOptions.asp?MKey=%7B2B8A95 F7%2D02F3%2D498E%2D9B55%2DA7E9C92A500E%7D&AKey=%7BA4C6DD8F%2D4BF2%2D 400D%2D97ED%2D20C14381CDBB%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects. AN - 68794194; 16937523 AB - To analyze the biological effects of prolonged in vitro exposure of HT-29 and LoVo colon cancer cell lines to gefitinib (Iressa), an inhibitor of epidermal growth factor receptor (EGFR) activity, and ZD6474, an inhibitor of both KDR and EGFR activities. Cells were treated with each drug for up to 2 wk using either a continuous or an intermittent (4 d of drug exposure followed by 3 d of washout each week) schedule. In both cell types, prolonged exposure (up to 14 d) to gefitinib or ZD6474 produced a similar inhibition of cell growth that was persistent and independent of the treatment schedule. The effects on cell growth were associated with a pronounced inhibition of p-EGFR and/or p-KDR expression. Treatment with gefitinib or ZD6474 also inhibited the expression of EGFR downstream signal molecules, p-Erk1/2 and p-Akt, although the magnitude of these effects varied between treatments and cell lines. Furthermore, expression of the drug resistance-related protein ABCG2 was shown to significantly increase after 14 d of continuous exposure to the two drugs. We conclude that long-term exposure of colon cancer cells to gefitinib and ZD6474 does not modify their cytotoxic effects but it might have an effect on sensitivity to classical cytotoxic drugs. JF - World journal of gastroenterology AU - Azzariti, Amalia AU - Porcelli, Letizia AU - Xu, Jian-Ming AU - Simone, Grazia Maria AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, National Cancer Institute, Bari, Italy. Y1 - 2006/08/28/ PY - 2006 DA - 2006 Aug 28 SP - 5140 EP - 5147 VL - 12 IS - 32 SN - 1007-9327, 1007-9327 KW - Piperidines KW - 0 KW - Quinazolines KW - Receptor, Epidermal Growth Factor KW - EC 2.7.10.1 KW - gefitinib KW - S65743JHBS KW - N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine KW - YO460OQ37K KW - Index Medicus KW - Drug Screening Assays, Antitumor KW - Humans KW - Cell Line, Tumor KW - Inhibitory Concentration 50 KW - Time Factors KW - Signal Transduction KW - Chromatography, High Pressure Liquid KW - Quinazolines -- administration & dosage KW - Receptor, Epidermal Growth Factor -- antagonists & inhibitors KW - Receptor, Epidermal Growth Factor -- metabolism KW - Colonic Neoplasms -- drug therapy KW - Piperidines -- administration & dosage KW - Drug Resistance, Neoplasm KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68794194?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=World+journal+of+gastroenterology&rft.atitle=Prolonged+exposure+of+colon+cancer+cells+to+the+epidermal+growth+factor+receptor+inhibitor+gefitinib+%28Iressa%28TM%29%29+and+to+the+antiangiogenic+agent+ZD6474%3A+Cytotoxic+and+biomolecular+effects.&rft.au=Azzariti%2C+Amalia%3BPorcelli%2C+Letizia%3BXu%2C+Jian-Ming%3BSimone%2C+Grazia+Maria%3BParadiso%2C+Angelo&rft.aulast=Azzariti&rft.aufirst=Amalia&rft.date=2006-08-28&rft.volume=12&rft.issue=32&rft.spage=5140&rft.isbn=&rft.btitle=&rft.title=World+journal+of+gastroenterology&rft.issn=10079327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-02-09 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Cancer Res. 2004 Apr 1;10(7):2512-24 [15073131] Semin Oncol. 2004 Feb;31(1 Suppl 3):3-8 [15052538] Biochem Pharmacol. 2004 Jul 1;68(1):135-44 [15183125] J Pharmacol Exp Ther. 2004 Aug;310(2):836-42 [15075385] Eur J Cancer. 2004 Aug;40(12):1807-9 [15288280] Cancer Cell. 2004 Aug;6(2):117-27 [15324695] J Cell Biol. 1982 Oct;95(1):73-7 [6128346] J Biol Chem. 1995 Mar 3;270(9):4334-40 [7876195] J Cell Biol. 1996 Mar;132(6):1011-23 [8601581] Breast Cancer Res. 2004;6(6):R616-28 [15535843] Mol Biol Cell. 2004 Dec;15(12):5470-80 [15469991] Cancer Res. 2005 Feb 15;65(4):1541-6 [15735043] Science. 2002 Mar 1;295(5560):1708-11 [11872838] Cancer Res. 2002 Aug 15;62(16):4645-55 [12183421] Cancer Res. 2002 Oct 15;62(20):5749-54 [12384534] Semin Oncol. 2003 Feb;30(1 Suppl 1):12-20 [12644980] Clin Cancer Res. 2003 Apr;9(4):1274-83 [12684395] Clin Cancer Res. 2003 Apr;9(4):1546-56 [12684431] Clin Cancer Res. 2003 Jun;9(6):2366-73 [12796407] J Clin Oncol. 2003 Jun 15;21(12):2237-46 [12748244] J Surg Res. 2003 May 15;111(2):274-83 [12850474] Biochem Pharmacol. 2003 Aug 15;66(4):551-63 [12906920] Clin Cancer Res. 2003 Oct 1;9(12):4340-6 [14555504] JAMA. 2003 Oct 22;290(16):2149-58 [14570950] Cancer Chemother Pharmacol. 2003 Dec;52(6):442-8 [13680161] J Biol Chem. 2000 Feb 25;275(8):5361-9 [10681510] FASEB J. 2000 Nov;14(14):2185-97 [11053239] Curr Drug Targets. 2000 Jul;1(1):85-99 [11475537] Clin Cancer Res. 2001 Dec;7(12):4156-63 [11751516] Oncologist. 2003;8(6):531-8 [14657531] Clin Cancer Res. 2004 Jan 15;10(2):784-93 [14760102] J Am Pharm Assoc (2003). 2004 Jan-Feb;44(1):52-8 [14965154] J Clin Oncol. 2004 Mar 1;22(5):777-84 [14990632] J Clin Oncol. 2004 Mar 1;22(5):785-94 [14990633] Mol Pharmacol. 2004 Jun;65(6):1485-95 [15155841] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Hepatic Gene Expression Profiles during Treatment with Peginterferon and Ribavirin: Identifying Important Molecular Pathways for Treatment Response T2 - 13th International Meeting on Hepatitis C Virus and Related Viruses AN - 40359023; 4421135 JF - 13th International Meeting on Hepatitis C Virus and Related Viruses AU - Liang, T Jake Y1 - 2006/08/27/ PY - 2006 DA - 2006 Aug 27 KW - Gene expression KW - Ribavirin KW - Liver KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40359023?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Hepatic+Gene+Expression+Profiles+during+Treatment+with+Peginterferon+and+Ribavirin%3A+Identifying+Important+Molecular+Pathways+for+Treatment+Response&rft.au=Liang%2C+T+Jake&rft.aulast=Liang&rft.aufirst=T&rft.date=2006-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/hepatitis2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mutations in the Putative HCV Fusion Peptide of E1 Affect Glycosylation of E2 and Pseudotyped Virus Infectivity T2 - 13th International Meeting on Hepatitis C Virus and Related Viruses AN - 40358970; 4421123 JF - 13th International Meeting on Hepatitis C Virus and Related Viruses AU - Russell, Rodney S Y1 - 2006/08/27/ PY - 2006 DA - 2006 Aug 27 KW - Mutation KW - Infectivity KW - Glycosylation KW - Peptides KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40358970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Mutations+in+the+Putative+HCV+Fusion+Peptide+of+E1+Affect+Glycosylation+of+E2+and+Pseudotyped+Virus+Infectivity&rft.au=Russell%2C+Rodney+S&rft.aulast=Russell&rft.aufirst=Rodney&rft.date=2006-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/hepatitis2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cd8 T Cells are Recruited to the Acutely HCV-Infected Liver by HCV RNA-Induced CXCR3- And CCR5-Ligands T2 - 13th International Meeting on Hepatitis C Virus and Related Viruses AN - 40356028; 4421299 JF - 13th International Meeting on Hepatitis C Virus and Related Viruses AU - Shin, Eui-Cheol Y1 - 2006/08/27/ PY - 2006 DA - 2006 Aug 27 KW - Liver KW - CD8 antigen KW - Lymphocytes T KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40356028?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Cd8+T+Cells+are+Recruited+to+the+Acutely+HCV-Infected+Liver+by+HCV+RNA-Induced+CXCR3-+And+CCR5-Ligands&rft.au=Shin%2C+Eui-Cheol&rft.aulast=Shin&rft.aufirst=Eui-Cheol&rft.date=2006-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/hepatitis2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cell Culture-Adapted JFH1 HCV is More Infectious than Wild-Type JFH1 T2 - 13th International Meeting on Hepatitis C Virus and Related Viruses AN - 40355958; 4421087 JF - 13th International Meeting on Hepatitis C Virus and Related Viruses AU - Russell, Rodney S Y1 - 2006/08/27/ PY - 2006 DA - 2006 Aug 27 KW - Structural proteins KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40355958?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Cell+Culture-Adapted+JFH1+HCV+is+More+Infectious+than+Wild-Type+JFH1&rft.au=Russell%2C+Rodney+S&rft.aulast=Russell&rft.aufirst=Rodney&rft.date=2006-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/hepatitis2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Monoclonal Antibodies Against HCV E1 that are as Effective as Those Against E2 in Broadly Neutralizing Retroviral Pseudoparticles and JFH1-Based Viruses T2 - 13th International Meeting on Hepatitis C Virus and Related Viruses AN - 40354339; 4421324 JF - 13th International Meeting on Hepatitis C Virus and Related Viruses AU - Meunier, Jean Christophe Y1 - 2006/08/27/ PY - 2006 DA - 2006 Aug 27 KW - Viruses KW - Monoclonal antibodies KW - Hepatitis C virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40354339?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.atitle=Monoclonal+Antibodies+Against+HCV+E1+that+are+as+Effective+as+Those+Against+E2+in+Broadly+Neutralizing+Retroviral+Pseudoparticles+and+JFH1-Based+Viruses&rft.au=Meunier%2C+Jean+Christophe&rft.aulast=Meunier&rft.aufirst=Jean&rft.date=2006-08-27&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=13th+International+Meeting+on+Hepatitis+C+Virus+and+Related+Viruses&rft.issn=&rft_id=info:doi/ L2 - http://www.icms.com.au/hepatitis2006/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combining Solution NMR and Small Angle Scattering for Macromolecular Structure Determination T2 - 2006 Keystone Symposia on Multi-Protein Complexes Involved in Cell Regulation (E6) AN - 40228970; 4351437 JF - 2006 Keystone Symposia on Multi-Protein Complexes Involved in Cell Regulation (E6) AU - Grishaev, Alexander Y1 - 2006/08/18/ PY - 2006 DA - 2006 Aug 18 KW - N.M.R. KW - Macromolecules KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40228970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Keystone+Symposia+on+Multi-Protein+Complexes+Involved+in+Cell+Regulation+%28E6%29&rft.atitle=Combining+Solution+NMR+and+Small+Angle+Scattering+for+Macromolecular+Structure+Determination&rft.au=Grishaev%2C+Alexander&rft.aulast=Grishaev&rft.aufirst=Alexander&rft.date=2006-08-18&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Keystone+Symposia+on+Multi-Protein+Complexes+Involved+in+Cell+Regulation+%28E6%29&rft.issn=&rft_id=info:doi/ L2 - http://www.keystonesymposia.org/Meetings/viewMeetings.cfm?MeetingID=81 8 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Improved perfusion conditions for patch-clamp recordings on human erythrocytes AN - 19962853; 7043710 AB - Various configurations of the patch-clamp method are powerful tools for examining the transport of charged solutes across biological membranes. Originally developed for the study of relatively large cells which adhere to solid surfaces under in vitro culture, these methods have been increasingly applied to small cells or organelles in suspension. Under these conditions, a number of significant technical problems may arise as a result of the smaller geometry. Here, we examined these problems using human erythrocytes infected with the malaria parasite, Plasmodium falciparum, a system where experimental differences and the technical difficulty of erythrocyte patch-clamp have hindered universal agreement on the properties of the induced ion channels. We found that patch-clamp recordings on infected erythrocytes are especially susceptible to artifacts from mechanical perturbations due to solution flow around the cell. To minimize these artifacts, we designed a new perfusion chamber whose geometry allows controlled solution flow around the fragile erythrocyte. Not only were recordings acquired in this chamber significantly less susceptible to perfusion artifacts, but the chamber permitted rapid and reversible application of known inhibitors with negligible mechanical agitation. Electrophysiological recordings then faithfully reproduced several findings made with more traditional methods. The new perfusion chamber should also be useful for patch-clamp recordings on blood cells, protoplasts, and organelles. JF - Biochemical and Biophysical Research Communications AU - Lisk, G AU - Desai, SA AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, sdesai@niaid.nih.gov Y1 - 2006/08/18/ PY - 2006 DA - 2006 Aug 18 SP - 158 EP - 165 VL - 347 IS - 1 SN - 0006-291X, 0006-291X KW - Microbiology Abstracts C: Algology, Mycology & Protozoology; Biotechnology and Bioengineering Abstracts KW - Parasites KW - Perfusion KW - Erythrocytes KW - Cell culture KW - Malaria KW - Plasmodium falciparum KW - Agitation KW - Electrophysiological recording KW - Solutes KW - Ion channels KW - Protoplasts KW - Blood cells KW - Organelles KW - W 30900:Methods KW - K 03420:Plant Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19962853?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=Improved+perfusion+conditions+for+patch-clamp+recordings+on+human+erythrocytes&rft.au=Lisk%2C+G%3BDesai%2C+SA&rft.aulast=Lisk&rft.aufirst=G&rft.date=2006-08-18&rft.volume=347&rft.issue=1&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Biochemical+and+Biophysical+Research+Communications&rft.issn=0006291X&rft_id=info:doi/10.1016%2Fj.bbrc.2006.06.058 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Parasites; Solutes; Electrophysiological recording; Perfusion; Ion channels; Erythrocytes; Protoplasts; Malaria; Cell culture; Blood cells; Agitation; Organelles; Plasmodium falciparum DO - http://dx.doi.org/10.1016/j.bbrc.2006.06.058 ER - TY - CPAPER T1 - Salvage Surgery after Organ Preservation Therapy in Patients with Stage III or IV Head and Neck Squamous Cell Carcinoma T2 - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AN - 40244083; 4354452 JF - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AU - Dias, F L AU - Lima, R A AU - Fernandes, K L AU - Costa, A.L.C. AU - Farias, T P AU - Kligerman, J AU - Herchenhorn, D AU - Toscano, U B Y1 - 2006/08/17/ PY - 2006 DA - 2006 Aug 17 KW - Surgery KW - Organs KW - Squamous cell carcinoma KW - Preservation KW - Head and neck cancer KW - Tumors KW - Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40244083?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.atitle=Salvage+Surgery+after+Organ+Preservation+Therapy+in+Patients+with+Stage+III+or+IV+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Dias%2C+F+L%3BLima%2C+R+A%3BFernandes%2C+K+L%3BCosta%2C+A.L.C.%3BFarias%2C+T+P%3BKligerman%2C+J%3BHerchenhorn%2C+D%3BToscano%2C+U+B&rft.aulast=Dias&rft.aufirst=F&rft.date=2006-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.ahns.info/download/AHNS_2006_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sebaceous Carcinoma of the Head and Neck: Outcome of 15 Consecutive Cases Treated in a Single Institution T2 - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AN - 40243482; 4354438 JF - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AU - Toscano, U B AU - Dias, F L AU - Lima, R A AU - Arcuri, R A AU - Barbosa, M M AU - Gisler, I S AU - Botelho Jr., F.G. AU - Kligerman, J AU - Fernandes, K L AU - Costa, A.L.C. Y1 - 2006/08/17/ PY - 2006 DA - 2006 Aug 17 KW - Head and neck carcinoma KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40243482?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.atitle=Sebaceous+Carcinoma+of+the+Head+and+Neck%3A+Outcome+of+15+Consecutive+Cases+Treated+in+a+Single+Institution&rft.au=Toscano%2C+U+B%3BDias%2C+F+L%3BLima%2C+R+A%3BArcuri%2C+R+A%3BBarbosa%2C+M+M%3BGisler%2C+I+S%3BBotelho+Jr.%2C+F.G.%3BKligerman%2C+J%3BFernandes%2C+K+L%3BCosta%2C+A.L.C.&rft.aulast=Toscano&rft.aufirst=U&rft.date=2006-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.ahns.info/download/AHNS_2006_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Combining the Proteasome Inhibitor Bortezomib with Reirradiation in Patients with Recurrent Head and Neck Squamous Cell Carcinoma T2 - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AN - 40241717; 4354489 JF - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AU - Allen, C T AU - Chen, Z AU - Van Waes, C. Y1 - 2006/08/17/ PY - 2006 DA - 2006 Aug 17 KW - Proteasome inhibitors KW - Squamous cell carcinoma KW - Head and neck cancer KW - Tumors KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40241717?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.atitle=Combining+the+Proteasome+Inhibitor+Bortezomib+with+Reirradiation+in+Patients+with+Recurrent+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Allen%2C+C+T%3BChen%2C+Z%3BVan+Waes%2C+C.&rft.aulast=Allen&rft.aufirst=C&rft.date=2006-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.ahns.info/download/AHNS_2006_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phase II Study: Concurrent Gemcitabine-Radiotherapy with Cetuximab in Locally Advanced Head and Neck Cancer (LAHNC) T2 - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AN - 40238904; 4354350 JF - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AU - Granados, M AU - Aguilar, J Luis AU - Lavin, A J AU - Frias, M AU - Maldonado, F AU - Luna, K AU - Cruz, J C AU - Moran, A AU - Martinez, J L AU - de la Garza, J Y1 - 2006/08/17/ PY - 2006 DA - 2006 Aug 17 KW - Head and neck cancer UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40238904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.atitle=Phase+II+Study%3A+Concurrent+Gemcitabine-Radiotherapy+with+Cetuximab+in+Locally+Advanced+Head+and+Neck+Cancer+%28LAHNC%29&rft.au=Granados%2C+M%3BAguilar%2C+J+Luis%3BLavin%2C+A+J%3BFrias%2C+M%3BMaldonado%2C+F%3BLuna%2C+K%3BCruz%2C+J+C%3BMoran%2C+A%3BMartinez%2C+J+L%3Bde+la+Garza%2C+J&rft.aulast=Granados&rft.aufirst=M&rft.date=2006-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.ahns.info/download/AHNS_2006_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Differential Protein Expression Patterns of p53, NF-KB, & NF-KB Regulated Genes in Head and Neck Squamous Cell Carcinoma T2 - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AN - 40237274; 4354331 JF - 2006 Annual Meeting and Research Workshop of the American Head and Neck Society on Biology, Prevention and Treatment of Head and Neck Cancer AU - Duggal, P AU - Chen, Z AU - Van Waes, C. Y1 - 2006/08/17/ PY - 2006 DA - 2006 Aug 17 KW - NF-B protein KW - Squamous cell carcinoma KW - P53 protein KW - Head and neck cancer KW - Tumors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40237274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.atitle=Differential+Protein+Expression+Patterns+of+p53%2C+NF-KB%2C+%26amp%3B+NF-KB+Regulated+Genes+in+Head+and+Neck+Squamous+Cell+Carcinoma&rft.au=Duggal%2C+P%3BChen%2C+Z%3BVan+Waes%2C+C.&rft.aulast=Duggal&rft.aufirst=P&rft.date=2006-08-17&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Research+Workshop+of+the+American+Head+and+Neck+Society+on+Biology%2C+Prevention+and+Treatment+of+Head+and+Neck+Cancer&rft.issn=&rft_id=info:doi/ L2 - http://www.ahns.info/download/AHNS_2006_Final_Program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Cannabinoid CB1 receptor antagonist AM251 inhibits cocaine-primed relapse in rats: role of glutamate in the nucleus accumbens. AN - 68752458; 16914679 AB - Blockade of cannabinoid CB1 receptors has been reported to inhibit cocaine- or cocaine cue-induced reinstatement of drug seeking. However, the mechanisms underlying this action are poorly understood. Given the importance of dopamine, glutamate, and GABA in cocaine reward and relapse, we studied the effects of AM251 [N-(piperidin-1-yl)-5-(4-iodophonyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide], a novel highly selective CB1 receptor antagonist, on cocaine-primed reinstatement of drug-seeking behavior and on cocaine-induced changes in extracellular DA, glutamate, and GABA in the nucleus accumbens (NAc) under reinstatement conditions. We found that systemic administration of AM251 selectively inhibited cocaine-induced, but not sucrose plus sucrose cue-induced, reinstatement of reward-seeking behavior. AM251 alone did not trigger reinstatement. Local perfusion of AM251 into the NAc or the dorsal striatum also inhibited cocaine-triggered reinstatement. AM251 alone dose dependently elevated NAc glutamate in a voltage-dependent Na+ channel-dependent manner. AM251 did not affect NAc DA or GABA. Pretreatment with AM251 dose dependently inhibited cocaine-induced increases in NAc glutamate but not in DA. Blockade of NAc metabotropic glutamate mGluR2/3 receptors by LY341495 [(2S)-2-amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid] slightly facilitated cocaine-enhanced glutamate release but blocked the antagonism of cocaine-induced reinstatement by AM251. These data suggest the following: (1) CB1 receptors exert tonic inhibition over NAc glutamate release under cocaine-extinction conditions; (2) blockade of CB1 receptors by AM251 inhibits cocaine-enhanced NAc glutamate release and cocaine-triggered reinstatement; and (3) these effects appear to be mediated by activation of presynaptic mGluR2/3 autoreceptors secondary to AM251-induced increase (disinhibition) of NAc glutamate release. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Xi, Zheng-Xiong AU - Gilbert, Jeremy G AU - Peng, Xiao-Qing AU - Pak, Arlene C AU - Li, Xia AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA. zxi@intra.nida.nih.gov Y1 - 2006/08/16/ PY - 2006 DA - 2006 Aug 16 SP - 8531 EP - 8536 VL - 26 IS - 33 KW - Piperidines KW - 0 KW - Pyrazoles KW - Receptor, Cannabinoid, CB1 KW - AM 251 KW - 3I4FA44MAI KW - Glutamic Acid KW - 3KX376GY7L KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Cocaine KW - I5Y540LHVR KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Rats KW - Behavior, Animal -- drug effects KW - Animals KW - Rats, Long-Evans KW - Reward KW - Extracellular Space -- metabolism KW - Dopamine -- metabolism KW - gamma-Aminobutyric Acid -- metabolism KW - Recurrence KW - Male KW - Piperidines -- pharmacology KW - Pyrazoles -- pharmacology KW - Receptor, Cannabinoid, CB1 -- antagonists & inhibitors KW - Glutamic Acid -- metabolism KW - Cocaine-Related Disorders -- psychology KW - Nucleus Accumbens -- metabolism KW - Cocaine-Related Disorders -- etiology KW - Cocaine -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68752458?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Cannabinoid+CB1+receptor+antagonist+AM251+inhibits+cocaine-primed+relapse+in+rats%3A+role+of+glutamate+in+the+nucleus+accumbens.&rft.au=Xi%2C+Zheng-Xiong%3BGilbert%2C+Jeremy+G%3BPeng%2C+Xiao-Qing%3BPak%2C+Arlene+C%3BLi%2C+Xia%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2006-08-16&rft.volume=26&rft.issue=33&rft.spage=8531&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Metabolic and skeletal complications of HIV infection: the price of success. AN - 68737344; 16905789 AB - Over the past 10 years, in conjunction with the broad availability of potent antiretroviral regimens, the care of human immunodeficiency virus (HIV)-infected patients has shifted from prevention and treatment of opportunistic infections and malignancies to management of the metabolic and related complications associated with HIV infection and its treatment. Metabolic disorders, including lipodystrophy, dyslipidemia, and insulin resistance, occur at a high rate in HIV-infected individuals receiving highly active antiretroviral therapy (HAART). These disorders are associated with increased risk of cardiovascular disease and have become an important cause of morbidity and mortality in HIV-infected patients. Herein, we present the case of a patient with HIV infection who responded well to HAART but developed multiple complications potentially related to this therapy. This article reviews the clinical characteristics of the metabolic and skeletal disturbances observed in HIV infection and discusses strategies for their management. JF - JAMA AU - Morse, Caryn G AU - Kovacs, Joseph A AD - National Institute of Allergy and Infectious Diseases-Clinical Center HIV/AIDS Program, Critical Care Medicine Department, NIH Clinical Center, Bethesda, Md, USA. Y1 - 2006/08/16/ PY - 2006 DA - 2006 Aug 16 SP - 844 EP - 854 VL - 296 IS - 7 KW - Abridged Index Medicus KW - Index Medicus KW - Cardiovascular Diseases -- epidemiology KW - Risk Factors KW - Humans KW - Middle Aged KW - Chronic Disease KW - Insulin Resistance KW - Male KW - Cardiovascular Diseases -- prevention & control KW - Hypertension -- complications KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - HIV-Associated Lipodystrophy Syndrome KW - HIV Infections -- complications KW - Diabetes Mellitus, Type 2 -- complications KW - HIV Infections -- drug therapy KW - Hyperlipidemias -- complications KW - Osteonecrosis -- complications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68737344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA&rft.atitle=Metabolic+and+skeletal+complications+of+HIV+infection%3A+the+price+of+success.&rft.au=Morse%2C+Caryn+G%3BKovacs%2C+Joseph+A&rft.aulast=Morse&rft.aufirst=Caryn&rft.date=2006-08-16&rft.volume=296&rft.issue=7&rft.spage=844&rft.isbn=&rft.btitle=&rft.title=JAMA&rft.issn=1538-3598&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-08-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Quantitative detection of p53 mutations in plasma DNA from tobacco smokers. AN - 68756643; 16912213 AB - In lung tumors, the p53 tumor suppressor gene is commonly mutated with a characteristic mutation spectrum. The amount of and alterations in plasma DNA, such as mutations in p53, were associated with several cancers. Few studies used quantitative methods of high sensitivity. Previously, we observed p53 mutations in the noncancerous tissue that differed from those in lung tumors using the highly sensitive p53 mutation load assay. Based on our observation of an increased p53 mutation load in nontumorous lung tissue in smokers, we hypothesized that plasma DNA may contain mutant p53 indicative of tobacco smoke exposure and will be an effective biomarker of lung cancer or smoking exposure. We modified the p53 mutation load assay to detect mutations at p53 codons 248 and 249, common mutations in lung cancer, in plasma DNA samples with a sensitivity of 1:5,000. The assay was applied to a set of lung cancer cases (n = 39), hospital controls (n = 21), and population controls (n = 20) from a larger study. Controls were selected to consist of equal numbers of both ever and never smokers. The p53 mutation load (mutated p53 copies per total number of p53 copies) was associated with smoking (P = 0.06), but not with lung cancer (P = 0.59). Most of the individuals with p53 mutations observed in plasma DNA were ever smokers and the p53 mutation load was higher in those who smoked for longer durations (P = 0.04). In summary, we were able to detect p53 mutations in plasma DNA from healthy individuals and our data suggest that p53 mutations in plasma DNA may be a marker of carcinogen exposure from tobacco smoke. JF - Cancer research AU - Hagiwara, Nobutoshi AU - Mechanic, Leah E AU - Trivers, Glenwood E AU - Cawley, Helen L AU - Taga, Masataka AU - Bowman, Elise D AU - Kumamoto, Kensuke AU - He, Peijun AU - Bernard, Mark AU - Doja, Saira AU - Miyashita, Masao AU - Tajiri, Takashi AU - Sasajima, Koji AU - Nomura, Tsutomu AU - Makino, Hiroshi AU - Takahashi, Ken AU - Hussain, S Perwez AU - Harris, Curtis C AD - Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-4258, USA. Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 8309 EP - 8317 VL - 66 IS - 16 KW - DNA KW - 9007-49-2 KW - Index Medicus KW - Polymerase Chain Reaction KW - Humans KW - Baltimore -- epidemiology KW - Cell Line KW - DNA -- isolation & purification KW - Lung Neoplasms -- etiology KW - Smoking -- blood KW - Lung Neoplasms -- epidemiology KW - Genes, p53 KW - DNA -- blood KW - DNA -- genetics KW - Lung Neoplasms -- genetics KW - Smoking -- genetics KW - Mutation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68756643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Quantitative+detection+of+p53+mutations+in+plasma+DNA+from+tobacco+smokers.&rft.au=Hagiwara%2C+Nobutoshi%3BMechanic%2C+Leah+E%3BTrivers%2C+Glenwood+E%3BCawley%2C+Helen+L%3BTaga%2C+Masataka%3BBowman%2C+Elise+D%3BKumamoto%2C+Kensuke%3BHe%2C+Peijun%3BBernard%2C+Mark%3BDoja%2C+Saira%3BMiyashita%2C+Masao%3BTajiri%2C+Takashi%3BSasajima%2C+Koji%3BNomura%2C+Tsutomu%3BMakino%2C+Hiroshi%3BTakahashi%2C+Ken%3BHussain%2C+S+Perwez%3BHarris%2C+Curtis+C&rft.aulast=Hagiwara&rft.aufirst=Nobutoshi&rft.date=2006-08-15&rft.volume=66&rft.issue=16&rft.spage=8309&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=1538-7445&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-11-13 N1 - Date created - 2006-08-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor-directed radiation and the immunotoxin SS1P in the treatment of mesothelin-expressing tumor xenografts. AN - 68753315; 16914588 AB - Mesothelin is a cell surface protein overexpressed in mesotheliomas and pancreatic and ovarian cancers. The goal of this study was to determine if radiation therapy in combination with the antimesothelin immunotoxin SS1(dsFv)PE38 (SS1P) would result in enhanced antitumor activity against mesothelin-expressing xenografts in nude mice. Female athymic nude mice bearing s.c. mesothelin-expressing xenografts were treated with SS1P alone, tumor-focused radiation alone, or the combination of the two. Two different regimens of the combination therapy were tested. In the low-dose combination schedule, mice were treated with either 5 Gy radiation alone, 0.2 mg/kg SS1P alone, or the same doses of radiation and SS1P in combination. In the high-dose combination experiments, mice were treated with either 15 Gy radiation alone, 0.3 mg/kg SS1P alone, or the combination of radiation and SS1P. In the low-dose radiation and SS1P combination studies, mice treated with the combination of radiation and SS1P had a statistically significant prolongation in time to tumor doubling or tripling compared with control, SS1P, or radiation alone. A similar increase in time to tumor doubling or tripling was seen in mice treated with high-dose radiation and SS1P combination. Combination of SS1P with tumor-directed radiation results in enhanced antitumor activity against mesothelin-expressing tumor xenografts. This effect was seen when either low or high doses of radiation were used. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Hassan, Raffit AU - Williams-Gould, Juanita AU - Steinberg, Seth M AU - Liewehr, David J AU - Yokokawa, Junko AU - Tsang, Kwong Y AU - Surawski, Robert J AU - Scott, Tamalee AU - Camphausen, Kevin AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA. hassanr@mail.nih.gov Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 4983 EP - 4988 VL - 12 IS - 16 SN - 1078-0432, 1078-0432 KW - GPI-Linked Proteins KW - 0 KW - Immunotoxins KW - Membrane Glycoproteins KW - mesothelin KW - Index Medicus KW - Animals KW - Combined Modality Therapy KW - Humans KW - Xenograft Model Antitumor Assays KW - Mice, Nude KW - Mice KW - Female KW - Membrane Glycoproteins -- biosynthesis KW - Carcinoma, Squamous Cell -- metabolism KW - Immunotoxins -- pharmacology KW - Membrane Glycoproteins -- immunology KW - Carcinoma, Squamous Cell -- radiotherapy KW - Carcinoma, Squamous Cell -- drug therapy KW - Carcinoma, Squamous Cell -- therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68753315?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=Tumor-directed+radiation+and+the+immunotoxin+SS1P+in+the+treatment+of+mesothelin-expressing+tumor+xenografts.&rft.au=Hassan%2C+Raffit%3BWilliams-Gould%2C+Juanita%3BSteinberg%2C+Seth+M%3BLiewehr%2C+David+J%3BYokokawa%2C+Junko%3BTsang%2C+Kwong+Y%3BSurawski%2C+Robert+J%3BScott%2C+Tamalee%3BCamphausen%2C+Kevin&rft.aulast=Hassan&rft.aufirst=Raffit&rft.date=2006-08-15&rft.volume=12&rft.issue=16&rft.spage=4983&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - A phase 1 study of ABT-751, an orally bioavailable tubulin inhibitor, administered daily for 7 days every 21 days in pediatric patients with solid tumors. AN - 68753257; 16914576 AB - To determine the toxicity profile, dose-limiting toxicities, and maximum tolerated dose of ABT-751 administered orally once daily for 7 days, repeated every 21 days. Patients who were 40% higher than the maximum tolerated dose in adults receiving the same dosing schedule. JF - Clinical cancer research : an official journal of the American Association for Cancer Research AU - Fox, Elizabeth AU - Maris, John M AU - Widemann, Brigitte C AU - Meek, Kysa AU - Goodwin, Anne AU - Goodspeed, Wendy AU - Kromplewski, Marie AU - Fouts, Molly E AU - Medina, Diane AU - Cho, Steve Y AU - Cohn, Susan L AU - Krivoshik, Andrew AU - Hagey, Anne E AU - Adamson, Peter C AU - Balis, Frank M AD - Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA. foxb@mail.nih.gov Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 4882 EP - 4887 VL - 12 IS - 16 SN - 1078-0432, 1078-0432 KW - ABT751 KW - 0 KW - Sulfonamides KW - Tubulin Modulators KW - Index Medicus KW - Administration, Oral KW - Dose-Response Relationship, Drug KW - Humans KW - Child KW - Adolescent KW - Male KW - Female KW - Child, Preschool KW - Tubulin Modulators -- administration & dosage KW - Neoplasms -- drug therapy KW - Sulfonamides -- adverse effects KW - Neoplasm Recurrence, Local -- drug therapy KW - Tubulin Modulators -- adverse effects KW - Sulfonamides -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68753257?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.atitle=A+phase+1+study+of+ABT-751%2C+an+orally+bioavailable+tubulin+inhibitor%2C+administered+daily+for+7+days+every+21+days+in+pediatric+patients+with+solid+tumors.&rft.au=Fox%2C+Elizabeth%3BMaris%2C+John+M%3BWidemann%2C+Brigitte+C%3BMeek%2C+Kysa%3BGoodwin%2C+Anne%3BGoodspeed%2C+Wendy%3BKromplewski%2C+Marie%3BFouts%2C+Molly+E%3BMedina%2C+Diane%3BCho%2C+Steve+Y%3BCohn%2C+Susan+L%3BKrivoshik%2C+Andrew%3BHagey%2C+Anne+E%3BAdamson%2C+Peter+C%3BBalis%2C+Frank+M&rft.aulast=Fox&rft.aufirst=Elizabeth&rft.date=2006-08-15&rft.volume=12&rft.issue=16&rft.spage=4882&rft.isbn=&rft.btitle=&rft.title=Clinical+cancer+research+%3A+an+official+journal+of+the+American+Association+for+Cancer+Research&rft.issn=10780432&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cohesin protein SMC1 represses the nuclear receptor CAR-mediated synergistic activation of a human P450 gene by xenobiotics. AN - 68657399; 16623664 AB - CAR (constitutive active/androstane receptor) regulates both the distal enhancer PBREM (phenobarbital-responsive enhancer module) and the proximal element OARE [OA (okadaic acid) response element] to synergistically up-regulate the endogenous CYP2B6 (where CYP is cytochrome P450) gene in HepG2 cells. In this up-regulation, CAR acts as both a transcription factor and a co-regulator, directly binding to and enhancing PBREM upon activation by xenobiotics such as TCPOBOP {1,4-bis-[2-(3,5-dichloropyridyloxy)]benzene} and indirectly associating with the OARE in response to OA [Swales, Kakizaki, Yamamoto, Inoue, Kobayashi and Negishi (2005) J. Biol. Chem. 280, 3458-3466]. We have now identified the cohesin protein SMC1 (structural maintenance of chromosomes 1) as a CAR-binding protein and characterized it as a negative regulator of OARE activity, thus repressing synergy. Treatment with SMC1 small interfering RNA augmented the synergistic up-regulation of CYP2B6 expression 20-fold in HepG2 cells, while transient co-expression of spliced form of SMC1 abrogated the synergistic activation of a 1.8 kb CYP2B6 promoter. SMC1 indirectly binds to a 19 bp sequence (-236/-217) immediately downstream from the OARE in the CYP2B6 promoter. Both DNA affinity and chromatin immunoprecipitation assays showed that OA treatment dissociates SMC1 from the CYP2B6 promoter, reciprocating the indirect binding of CAR to OARE. These results are consistent with the conclusion that SMC1 binding represses OARE activity and its dissociation allows the recruitment of CAR to the OARE, synergizing PBREM activity and the expression of the CYP2B6 gene. JF - The Biochemical journal AU - Inoue, Kaoru AU - Borchers, Christoph H AU - Negishi, Masahiko AD - Pharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA. Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 125 EP - 133 VL - 398 IS - 1 KW - Cell Cycle Proteins KW - 0 KW - Chromosomal Proteins, Non-Histone KW - Pyridines KW - RNA, Small Interfering KW - Receptors, Cytoplasmic and Nuclear KW - Repressor Proteins KW - Transcription Factors KW - Xenobiotics KW - constitutive androstane receptor KW - structural maintenance of chromosome protein 1 KW - Okadaic Acid KW - 1W21G5Q4N2 KW - 1,4-bis(2-(3,5-dichloropyridyloxy))benzene KW - 76150-91-9 KW - Aryl Hydrocarbon Hydroxylases KW - EC 1.14.14.1 KW - CYP2B6 protein, human KW - Cytochrome P-450 CYP2B6 KW - Oxidoreductases, N-Demethylating KW - EC 1.5.- KW - Index Medicus KW - Animals KW - Humans KW - Gene Expression KW - RNA, Small Interfering -- genetics KW - Mice KW - Protein Binding KW - Base Sequence KW - Tumor Cells, Cultured KW - Enzyme Induction -- drug effects KW - Promoter Regions, Genetic -- drug effects KW - Sequence Deletion -- genetics KW - Okadaic Acid -- pharmacology KW - Response Elements -- genetics KW - Promoter Regions, Genetic -- genetics KW - Pyridines -- pharmacology KW - Oxidoreductases, N-Demethylating -- genetics KW - Chromosomal Proteins, Non-Histone -- isolation & purification KW - Transcription Factors -- antagonists & inhibitors KW - Transcription Factors -- metabolism KW - Repressor Proteins -- metabolism KW - Xenobiotics -- pharmacology KW - Cell Cycle Proteins -- isolation & purification KW - Chromosomal Proteins, Non-Histone -- metabolism KW - Cell Cycle Proteins -- metabolism KW - Chromosomal Proteins, Non-Histone -- deficiency KW - Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors KW - Repressor Proteins -- isolation & purification KW - Aryl Hydrocarbon Hydroxylases -- metabolism KW - Receptors, Cytoplasmic and Nuclear -- metabolism KW - Aryl Hydrocarbon Hydroxylases -- genetics KW - Oxidoreductases, N-Demethylating -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68657399?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Biochemical+journal&rft.atitle=Cohesin+protein+SMC1+represses+the+nuclear+receptor+CAR-mediated+synergistic+activation+of+a+human+P450+gene+by+xenobiotics.&rft.au=Inoue%2C+Kaoru%3BBorchers%2C+Christoph+H%3BNegishi%2C+Masahiko&rft.aulast=Inoue&rft.aufirst=Kaoru&rft.date=2006-08-15&rft.volume=398&rft.issue=1&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=The+Biochemical+journal&rft.issn=1470-8728&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-22 N1 - Date created - 2006-07-21 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Anal Chem. 2000 Mar 15;72(6):1163-8 [10740854] J Cell Biol. 2002 Feb 4;156(3):419-24 [11815634] Annu Rev Pharmacol Toxicol. 2001;41:123-43 [11264453] Mol Pharmacol. 2002 Jan;61(1):1-6 [11752199] Genome Biol. 2002;3(2):REVIEWS3003 [11864377] Nat Rev Mol Cell Biol. 2002 Oct;3(10):767-78 [12360193] Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4156-61 [12644704] J Biol Chem. 2003 May 9;278(19):16698-705 [12609981] Nat Rev Genet. 2003 Jul;4(7):520-34 [12838344] Mol Pharmacol. 2003 Nov;64(5):1069-75 [14573755] IUBMB Life. 2003 Dec;55(12):643-52 [14769000] J Biol Chem. 2004 Apr 16;279(16):16875-82 [14761960] J Biol Chem. 2004 May 7;279(19):19832-8 [15004031] Genes Dev. 2004 Jun 15;18(12):1423-38 [15175241] Mol Endocrinol. 2004 Jul;18(7):1589-98 [14988430] Cancer Res. 2004 Oct 15;64(20):7197-200 [15492232] Annu Rev Pharmacol Toxicol. 1990;30:465-500 [2188576] Mol Pharmacol. 1998 Apr;53(4):597-601 [9547348] J Biol Chem. 1998 Sep 11;273(37):24088-94 [9727028] Mol Cell Biol. 1998 Oct;18(10):5652-8 [9742082] J Biol Chem. 1999 Mar 5;274(10):6043-6 [10037683] Gene. 1999 Mar 4;228(1-2):169-79 [10072770] Genetics. 1999 Jun;152(2):577-93 [10353901] Mol Cell Biol. 1999 Sep;19(9):6318-22 [10454578] J Biol Chem. 2005 Feb 4;280(5):3458-66 [15563456] Endocrinology. 2005 Mar;146(3):995-1002 [15564320] Methods Mol Biol. 2005;301:117-51 [15917630] Nature. 2000 Oct 19;407(6806):920-3 [11057673] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tumor suppressive activity of a variant isoform of manganese superoxide dismutase released by a human liposarcoma cell line. AN - 68054274; 16550599 AB - A cell line derived from a pleiomorphic liposarcoma, named LSA, was previously reported to secrete (a) factor(s) exhibiting oncotoxic properties. The present article describes the isolation, purification and sequence analysis of a protein released by LSA cells into conditioned culture medium. This protein proved to be a variant isoform of manganese superoxide dismutase (MnSOD), hence its designation as LSA-type-MnSOD. This LSA-type-SOD differed from conventional SODs in its secretion by producer cells, contrasting with the normal localization of SODs in the mitochondrial matrix. Interestingly, during the protein purification process, LSA-type-SOD cosegregated with a cytotoxic activity directed against a number of tumor cell lines, as determined under in vitro conditions. This cytopathic effect was most likely due to LSA-type-SOD, since it could be fully reproduced using recombinant SOD that was expressed from cDNA clones isolated from LSA cells mRNA preparations and henceforth designated L-rSOD. In addition to its manifestation in cell lines kept in tissue culture, the oncotoxicity of LSA-type-SOD was further reflected in a remarkable capacity of this protein for suppression of mammary tumors in Balb-C-FR(III) mice. Animals subcutaneously injected with L-rSOD in the tumor area showed a complete disruption of established mammary carcinomas, as monitored by nuclear magnetic resonance (NMR) scanning. Moreover, metastatic spreading, which was readily detected in the control group, was suppressed in the treated animals. Altogether these data suggest that LSA-type-SOD interferes with survival and spreading of neoplastically transformed cells and deserves to be future validated as a therapeutic agent against cancer, either alone or in combination with conventional treatments. Copyright 2006 Wiley-Liss, Inc. JF - International journal of cancer AU - Mancini, Aldo AU - Borrelli, Antonella AU - Schiattarella, Antonella AU - Fasano, Stefania AU - Occhiello, Antonella AU - Pica, Alessandra AU - Sehr, Peter AU - Tommasino, Massimo AU - Nüesch, Jürg P F AU - Rommelaere, Jean AD - National Cancer Institute G. Pascale, Naples, Italy. e.burkard@dkfz.de Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 932 EP - 943 VL - 119 IS - 4 SN - 0020-7136, 0020-7136 KW - Culture Media KW - 0 KW - DNA, Complementary KW - Isoenzymes KW - Tumor Suppressor Proteins KW - Superoxide Dismutase KW - EC 1.15.1.1 KW - Index Medicus KW - Isoenzymes -- chemistry KW - Isoenzymes -- secretion KW - Animals KW - DNA, Complementary -- genetics KW - Culture Media -- isolation & purification KW - Humans KW - Mice KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Isoenzymes -- genetics KW - Isoenzymes -- metabolism KW - Microscopy, Electron, Transmission KW - Base Sequence KW - Culture Media -- toxicity KW - Molecular Sequence Data KW - Xenograft Model Antitumor Assays KW - Superoxide Dismutase -- secretion KW - Liposarcoma -- genetics KW - Liposarcoma -- secretion KW - Tumor Suppressor Proteins -- secretion KW - Tumor Suppressor Proteins -- metabolism KW - Tumor Suppressor Proteins -- genetics KW - Superoxide Dismutase -- metabolism KW - Superoxide Dismutase -- genetics KW - Superoxide Dismutase -- chemistry KW - Liposarcoma -- pathology KW - Liposarcoma -- enzymology KW - Tumor Suppressor Proteins -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68054274?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+cancer&rft.atitle=Tumor+suppressive+activity+of+a+variant+isoform+of+manganese+superoxide+dismutase+released+by+a+human+liposarcoma+cell+line.&rft.au=Mancini%2C+Aldo%3BBorrelli%2C+Antonella%3BSchiattarella%2C+Antonella%3BFasano%2C+Stefania%3BOcchiello%2C+Antonella%3BPica%2C+Alessandra%3BSehr%2C+Peter%3BTommasino%2C+Massimo%3BN%C3%BCesch%2C+J%C3%BCrg+P+F%3BRommelaere%2C+Jean&rft.aulast=Mancini&rft.aufirst=Aldo&rft.date=2006-08-15&rft.volume=119&rft.issue=4&rft.spage=932&rft.isbn=&rft.btitle=&rft.title=International+journal+of+cancer&rft.issn=00207136&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2006-06-08 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Automated Quantification Tool for High-Throughput Proteomics Using Stable Isotope Labeling and LC-MS@un AN - 19642760; 7371013 AB - LC-MS@un has become a popular option for high-throughput quantitative proteomics, thanks to the availability of stable-isotope labeling reagents. However, the vast quantity of data generated from LC-MS@un continues to make the postacquisition quantification analyses challenging, especially in experiments involving multiple samples per experimental condition. To facilitate data analysis, we developed a computer program, QUIL, for automated protein quantification. QUIL accounts for the dynamic nature of spectral background and subtracts this background accordingly during ion chromatogram reconstruction. For elution profile identification, QUIL minimizes the inclusion of coeluted neighbor peaks, yet tolerates imperfect peak shapes. Outlier-resistant methods have been implemented for better protein ratio estimation. The utility of QUIL was validated by quantitative analyses of a standard protein as well as complex protein mixtures, which were labeled with cICAT or @@u18@O and analyzed using LCQ, LTQ, or FT-ICR instruments. For samples that no prior knowledge of relative protein quantities was available, Western blotting was performed for confirmation. For the standard protein, the coefficient of variation (CV) of peptide ratio estimation was 6%. For complex mixtures, the median CV for protein ratio calculations was less than 10%. Computed protein abundance ratios exhibited a relatively high degree of correlation with those obtained from Western blot analyses. Compared with a widely used commercial software tool, QUIL showed improvement in ion chromatogram construction and peak integration andsignificantly reduced relative errors in abundance ratio assessment. JF - Analytical Chemistry (Washington) AU - Wang, G AU - Wu, W W AU - Pisitkun, T AU - Hoffert, J D AU - Knepper, MA AU - Shen, R-F AD - Proteomics Core Facility and Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA Y1 - 2006/08/15/ PY - 2006 DA - 2006 Aug 15 SP - 5752 EP - 5761 VL - 78 IS - 16 SN - 0003-2700, 0003-2700 KW - Biotechnology and Bioengineering Abstracts KW - Integration KW - Computer programs KW - Western blotting KW - software KW - Isotopes KW - Data processing KW - proteomics KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19642760?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Analytical+Chemistry+%28Washington%29&rft.atitle=Automated+Quantification+Tool+for+High-Throughput+Proteomics+Using+Stable+Isotope+Labeling+and+LC-MS%40un&rft.au=Wang%2C+G%3BWu%2C+W+W%3BPisitkun%2C+T%3BHoffert%2C+J+D%3BKnepper%2C+MA%3BShen%2C+R-F&rft.aulast=Wang&rft.aufirst=G&rft.date=2006-08-15&rft.volume=78&rft.issue=16&rft.spage=5752&rft.isbn=&rft.btitle=&rft.title=Analytical+Chemistry+%28Washington%29&rft.issn=00032700&rft_id=info:doi/10.1021%2Fac060611v LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Western blotting; proteomics; Computer programs; Integration; Data processing; Isotopes; software DO - http://dx.doi.org/10.1021/ac060611v ER - TY - JOUR T1 - Effects of tarantula toxin GsMTx4 on the membrane motor of outer hair cells. AN - 68646725; 16797839 AB - GsMTx4, a cationic hydrophobic peptide isolated from tarantula venom, is a specific inhibitor of stretch-activated channels (SACs). Here, we show that the toxin also affects the membrane motor of outer hair cells at low doses. The membrane motor of outer hair cells is based on prestin, a member of the SLC26 family of membrane proteins, and directly uses electrical energy available at the plasma membrane. It is considered to be an essential part of the "cochlear amplifier," which increases the sensitivity, tuning, and dynamic range of the mammalian ear. The toxin shifts the operating point of the motor. The saturating value of the voltage shift is (26 +/- 1) mV, capable of significantly reducing the performance of the cochlear amplifier. The dissociation constant is (3.1 +/- 0.6) microM, about five-fold higher than that for SACs. JF - Neuroscience letters AU - Fang, Jie AU - Iwasa, K H AD - Section on Biophysics, LCB, NIDCD, NIH, Bethesda, MD 20892-8027, USA. Y1 - 2006/08/14/ PY - 2006 DA - 2006 Aug 14 SP - 213 EP - 216 VL - 404 IS - 1-2 SN - 0304-3940, 0304-3940 KW - MTx4 protein, Grammostola spatulata KW - 0 KW - Peptides KW - Spider Venoms KW - Index Medicus KW - Animals KW - Guinea Pigs KW - Cell Membrane -- drug effects KW - Membrane Potentials -- physiology KW - Membrane Potentials -- drug effects KW - Spider Venoms -- toxicity KW - Hair Cells, Auditory, Outer -- drug effects KW - Hair Cells, Auditory, Outer -- pathology KW - Peptides -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68646725?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience+letters&rft.atitle=Effects+of+tarantula+toxin+GsMTx4+on+the+membrane+motor+of+outer+hair+cells.&rft.au=Fang%2C+Jie%3BIwasa%2C+K+H&rft.aulast=Fang&rft.aufirst=Jie&rft.date=2006-08-14&rft.volume=404&rft.issue=1-2&rft.spage=213&rft.isbn=&rft.btitle=&rft.title=Neuroscience+letters&rft.issn=03043940&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-18 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Gen Physiol. 2000 May;115(5):583-98 [10779316] Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4420-5 [10200277] Otolaryngol Head Neck Surg. 2001 Jul;125(1):71-6 [11458218] Biophys J. 2002 Mar;82(3):1254-9 [11867442] Nature. 2002 Sep 19;419(6904):300-4 [12239568] Nature. 2004 Jul 8;430(6996):235-40 [15241420] J Cell Biol. 1976 Jul;70(1):247-51 [932100] Science. 1985 Jan 11;227(4683):194-6 [3966153] Nature. 1986 Jul 24-30;322(6077):365-8 [3736662] J Physiol. 1987 Jul;388:323-47 [3656195] Neurosci Res Suppl. 1990;12:S39-50 [2243636] J Neurosci. 1991 Oct;11(10):3096-110 [1941076] Biophys J. 1993 Jul;65(1):492-8 [8369452] Science. 1995 Mar 31;267(5206):2006-9 [7701325] Biophys J. 1997 Jul;73(1):546-55 [9199816] Nature. 2000 May 11;405(6783):149-55 [10821263] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Preservation of a subset of SIV-Specific CD4+ T Cells with Central Memory Markers Correlates to Control of Viremia in SIVmac251 Infected Macaques T2 - XVI International AIDS Conference (AIDS 2006) AN - 40154232; 4315132 JF - XVI International AIDS Conference (AIDS 2006) AU - Von Gegerfelt, A AU - Valentin, A AU - Patel, V AU - Rosati, M AU - Alicea, C AU - Morrow, M AU - Felber, B AU - Pavlakis, G Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Memory cells KW - Preservation KW - Lymphocytes T KW - CD4 antigen KW - Viremia KW - Macaca KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40154232?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Preservation+of+a+subset+of+SIV-Specific+CD4%2B+T+Cells+with+Central+Memory+Markers+Correlates+to+Control+of+Viremia+in+SIVmac251+Infected+Macaques&rft.au=Von+Gegerfelt%2C+A%3BValentin%2C+A%3BPatel%2C+V%3BRosati%2C+M%3BAlicea%2C+C%3BMorrow%2C+M%3BFelber%2C+B%3BPavlakis%2C+G&rft.aulast=Von+Gegerfelt&rft.aufirst=A&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Non-Infectious Papilloma Virus - Like Particles (VLPs) Inhibit HIV Replication: Implications for Immune Control of HIV Replication by IL-27 T2 - XVI International AIDS Conference (AIDS 2006) AN - 40149516; 4314627 JF - XVI International AIDS Conference (AIDS 2006) AU - Fakruddin, J M AU - Lempicki, R AU - Yang, J AU - Adelsberger, J AU - Pineres, A AU - Pinto, L AU - Lane, H C AU - Imamichi, T Y1 - 2006/08/13/ PY - 2006 DA - 2006 Aug 13 KW - Particulates KW - Replication KW - Human immunodeficiency virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40149516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.atitle=Non-Infectious+Papilloma+Virus+-+Like+Particles+%28VLPs%29+Inhibit+HIV+Replication%3A+Implications+for+Immune+Control+of+HIV+Replication+by+IL-27&rft.au=Fakruddin%2C+J+M%3BLempicki%2C+R%3BYang%2C+J%3BAdelsberger%2C+J%3BPineres%2C+A%3BPinto%2C+L%3BLane%2C+H+C%3BImamichi%2C+T&rft.aulast=Fakruddin&rft.aufirst=J&rft.date=2006-08-13&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=XVI+International+AIDS+Conference+%28AIDS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.aids2006.org/PAG/ProgrammeAtAGlance.aspx LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Activation of Src/kinase/phospholipase C/mitogen-activated protein kinase and induction of neurite expression by ATP, independent of nerve growth factor. AN - 68595994; 16730415 AB - Extracellular ATP has been reported to potentiate the neurite outgrowth induced by nerve growth factor. In the present study the neurotrophic effect of ATP and other nucleotides was examined in mouse neuroblastoma neuro2a cells which lack nerve growth factor receptor. Exposure of neuro2a cells to ATP resulted in a dramatic increase in neurite bearing cells as compared with untreated control cells. Experiments performed with purinergic receptor agonists and antagonists suggest that the ATP stimulates neurite outgrowth via P2 receptors. Neurite outgrowth was completely blocked by P2 receptor antagonist suramin whereas the P1 receptor antagonist CGS15943 was ineffective. P1 receptor agonist 5'-(N-ethylcarboxamido)adenosine failed to induce neurite outgrowth. The potency order of different P2 receptor agonists was ATP=ATPgammaS>ADP>>2Me-S-ATP. It was insensitive to UTP and antagonist pyridoxal phosphate-6-azo (benzene-2,4-disulfonic acid) suggesting the involvement of P2Y11 receptor in the observed neuritogenic effect. The signaling pathway leading to ATP-induced neuritogenesis was investigated. The neuritogenic effect of ATP is independent of rise in intracellular Ca(2+) as pharmacological profile of neuritogenic P2Y receptor does not match with that of P2Y2 receptor associated with [Ca(2+)](i) signaling cascade. Exposure of cells to ATP caused activation of Src kinase, phospholipase Cgamma and extracellular signal-regulated kinases ERK1/2. Mitogen-activated protein kinase (MAPK) inhibitor U0126 drastically reduced the number of neurite bearing cells in ATP-treated cultures implying that the neurotrophic effect of ATP is mediated by MAPK. Our results demonstrate that ATP can stimulate neurite outgrowth independent of other neurotrophic factors and can be an effective trophic agent. JF - Neuroscience AU - Lakshmi, S AU - Joshi, P G AD - Department of Biophysics, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India. Y1 - 2006/08/11/ PY - 2006 DA - 2006 Aug 11 SP - 179 EP - 189 VL - 141 IS - 1 SN - 0306-4522, 0306-4522 KW - Butadienes KW - 0 KW - Enzyme Inhibitors KW - Nitriles KW - P2ry1 protein, mouse KW - P2ry2 protein, mouse KW - Purinergic P2 Receptor Agonists KW - Purinergic P2 Receptor Antagonists KW - Receptors, Purinergic P2 KW - Receptors, Purinergic P2Y1 KW - Receptors, Purinergic P2Y2 KW - U 0126 KW - pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid KW - 149017-66-3 KW - adenosine 5'-O-(3-thiotriphosphate) KW - 35094-46-3 KW - Pyridoxal Phosphate KW - 5V5IOJ8338 KW - Suramin KW - 6032D45BEM KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - src-Family Kinases KW - EC 2.7.10.2 KW - Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Type C Phospholipases KW - EC 3.1.4.- KW - Adenosine KW - K72T3FS567 KW - Index Medicus KW - Animals KW - Drug Interactions KW - Nitriles -- pharmacology KW - Cell Line, Tumor KW - Immunohistochemistry -- methods KW - Mice KW - Suramin -- pharmacology KW - Neuroblastoma KW - Adenosine -- pharmacology KW - Butadienes -- pharmacology KW - Receptors, Purinergic P2 -- metabolism KW - Pyridoxal Phosphate -- pharmacology KW - Enzyme Activation -- drug effects KW - Enzyme Inhibitors -- pharmacology KW - Pyridoxal Phosphate -- analogs & derivatives KW - Microscopy, Confocal -- methods KW - Neurites -- drug effects KW - Mitogen-Activated Protein Kinases -- metabolism KW - Adenosine Triphosphate -- analogs & derivatives KW - src-Family Kinases -- metabolism KW - Type C Phospholipases -- metabolism KW - Adenosine Triphosphate -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68595994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroscience&rft.atitle=Activation+of+Src%2Fkinase%2Fphospholipase+C%2Fmitogen-activated+protein+kinase+and+induction+of+neurite+expression+by+ATP%2C+independent+of+nerve+growth+factor.&rft.au=Lakshmi%2C+S%3BJoshi%2C+P+G&rft.aulast=Lakshmi&rft.aufirst=S&rft.date=2006-08-11&rft.volume=141&rft.issue=1&rft.spage=179&rft.isbn=&rft.btitle=&rft.title=Neuroscience&rft.issn=03064522&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Transcriptional inactivation of a regulatory site for replication of Vibrio cholerae chromosome II AN - 19362286; 7132730 AB - The bacterium Vibrio cholerae has two chromosomes. The origin of replication of chromosome I is similar to that of Escherichia coli. The origin-containing region of chromosome II (oriCII) resembles replicons of plasmids such as P1, except for the presence of an additional gene, rctA [Egan, E. S. & Waldor, M. K. (2003) Cell 114, 521-530]. The oriCII region that includes the initiator gene, rctB, can function as a plasmid in E. coli. Here we show that RctB suffices for the oriCII-based plasmid replication, and rctA in cis or trans reduces the plasmid copy number, thereby serving as a negative regulator. The inhibitory activity could be overcome by increasing the concentration of RctB, suggesting that rctA titrates the initiator. Purified RctB bound to a DNA fragment carrying rctA, confirming that the two can interact. Although rctA apparently works as a titrating site, it is nonetheless transcribed. We find that the transcription attenuates the inhibitory activity of the gene, presumably by interfering with RctB binding. RctB, in turn, repressed the rctA promoter and, thereby, could control its own titration by modulating the transcription of rctA. This control circuit appears to be a putative novel mechanism for homeostasis of initiator availability. JF - Proceedings of the National Academy of Sciences, USA AU - Venkova-Canova, Tatiana AU - Srivastava, Preeti AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-4260 Y1 - 2006/08/08/ PY - 2006 DA - 2006 Aug 08 SP - 12051 EP - 12056 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 32 SN - 0027-8424, 0027-8424 KW - Genetics Abstracts; ASFA 1: Biological Sciences & Living Resources; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - chromosome I KW - Replication KW - Transcription KW - Circuits KW - Homeostasis KW - chromosome II KW - Plasmids KW - copy number KW - Vibrio cholerae KW - Population genetics KW - Promoters KW - Chromosomes KW - Titration KW - Escherichia coli KW - Replication origins KW - DNA KW - J 02310:Genetics & Taxonomy KW - Q1 08205:Genetics and evolution KW - G 07770:Bacteria KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19362286?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Transcriptional+inactivation+of+a+regulatory+site+for+replication+of+Vibrio+cholerae+chromosome+II&rft.au=Venkova-Canova%2C+Tatiana%3BSrivastava%2C+Preeti%3BChattoraj%2C+Dhruba+K&rft.aulast=Venkova-Canova&rft.aufirst=Tatiana&rft.date=2006-08-08&rft.volume=103&rft.issue=32&rft.spage=12051&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Promoters; Population genetics; Chromosomes; Replication; Titration; DNA; Plasmids; chromosome I; Transcription; Circuits; chromosome II; Homeostasis; copy number; Replication origins; Vibrio cholerae; Escherichia coli ER - TY - JOUR T1 - Mice lacking uteroglobin are highly susceptible to developing pulmonary fibrosis. AN - 68703447; 16872605 AB - Uteroglobin (UG) is an anti-inflammatory protein secreted by the airway epithelia of all mammals. UG-knockout (UG-KO) mice sporadically develop focal pulmonary fibrosis (PF), a group of complex interstitial disorders of the lung that has high mortality and morbidity; however, the molecular mechanism(s) remains unclear. We report here that UG-KO mice are extraordinarily sensitive to bleomycin, an anti-cancer agent known to induce PF and readily develop PF when treated with an extremely low dose of bleomycin that has virtually no effect on the wild type littermates. We further demonstrate that UG prevents PF suppressing bleomycin-induced production of pro-inflammatory T-helper 2 cytokines and TGF-beta, which are also pro-fibrotic. Our results define a critical role of UG in preventing the development of PF and provide the proof of principle that recombinant UG may have therapeutic potential. JF - FEBS letters AU - Lee, Yi-Ching AU - Zhang, Zhongjian AU - Mukherjee, Anil B AD - Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, The National Institutes of Health, Building 10, Rm 9D42, 10, Center Drive, Bethesda, MD 20892-1830, USA. Y1 - 2006/08/07/ PY - 2006 DA - 2006 Aug 07 SP - 4515 EP - 4520 VL - 580 IS - 18 SN - 0014-5793, 0014-5793 KW - Biomarkers KW - 0 KW - Cytokines KW - Bleomycin KW - 11056-06-7 KW - Uteroglobin KW - 9060-09-7 KW - Index Medicus KW - Lung -- immunology KW - Animals KW - Pneumonia -- chemically induced KW - Biomarkers -- metabolism KW - Mice KW - Cytokines -- metabolism KW - Lung -- metabolism KW - Th2 Cells -- immunology KW - Survival Analysis KW - Mice, Knockout KW - Pulmonary Fibrosis -- immunology KW - Uteroglobin -- genetics KW - Pulmonary Fibrosis -- pathology KW - Pulmonary Fibrosis -- chemically induced KW - Uteroglobin -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703447?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=FEBS+letters&rft.atitle=Mice+lacking+uteroglobin+are+highly+susceptible+to+developing+pulmonary+fibrosis.&rft.au=Lee%2C+Yi-Ching%3BZhang%2C+Zhongjian%3BMukherjee%2C+Anil+B&rft.aulast=Lee&rft.aufirst=Yi-Ching&rft.date=2006-08-07&rft.volume=580&rft.issue=18&rft.spage=4515&rft.isbn=&rft.btitle=&rft.title=FEBS+letters&rft.issn=00145793&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Expression of Antisense Transcripts in Male Germ Cells T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39287742; 4312986 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Chan, Wai-Yee AU - Lee, Tin-Lap AU - Wu, Shao-Ming AU - Ruszczyk, Lisa AU - Baxendale, Vanessa AU - Rennert, Owen AU - Spector, Tim AU - Peltonen, Leena Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Antisense KW - Germ cells KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39287742?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=Expression+of+Antisense+Transcripts+in+Male+Germ+Cells&rft.au=Chan%2C+Wai-Yee%3BLee%2C+Tin-Lap%3BWu%2C+Shao-Ming%3BRuszczyk%2C+Lisa%3BBaxendale%2C+Vanessa%3BRennert%2C+Owen%3BSpector%2C+Tim%3BPeltonen%2C+Leena&rft.aulast=Chan&rft.aufirst=Wai-Yee&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Mutation in the OFD 1 Gene in A Filipino Child with Oral Facial Digital Syndrome Type 1 T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39241235; 4313314 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Cutiongco, Eva Maria AU - Chiong, M AU - Novelli, V AU - Franco, B Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Mutation KW - Symptoms KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39241235?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=A+Novel+Mutation+in+the+OFD+1+Gene+in+A+Filipino+Child+with+Oral+Facial+Digital+Syndrome+Type+1&rft.au=Cutiongco%2C+Eva+Maria%3BChiong%2C+M%3BNovelli%2C+V%3BFranco%2C+B&rft.aulast=Cutiongco&rft.aufirst=Eva&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Variants of Cyclooxygenase-2: Association with Advanced Colorectal Adenomas T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39238855; 4313024 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Ali, Iqbal AU - Tsang, Shirley AU - Poirier, Richard AU - Luke, Brian AU - Ashktorab, Hassan AU - Munroe, David AU - Greenwald, Peter Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Adenoma KW - Cyclooxygenase-2 KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39238855?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=Genetic+Variants+of+Cyclooxygenase-2%3A+Association+with+Advanced+Colorectal+Adenomas&rft.au=Ali%2C+Iqbal%3BTsang%2C+Shirley%3BPoirier%2C+Richard%3BLuke%2C+Brian%3BAshktorab%2C+Hassan%3BMunroe%2C+David%3BGreenwald%2C+Peter&rft.aulast=Ali&rft.aufirst=Iqbal&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Protein Translation and Human Genetic Disease: Studying the Role of tRNA-Charging Enzymes in Neuronal Health T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39231882; 4312578 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Antonellis, Anthony AU - Lee-Lin, Shih-Queen AU - Maduro, Valerie AU - Wasterlain, Amy AU - Fischbeck, Kenneth AU - Green, Eric Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Enzymes KW - Translation KW - Public health KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39231882?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=Protein+Translation+and+Human+Genetic+Disease%3A+Studying+the+Role+of+tRNA-Charging+Enzymes+in+Neuronal+Health&rft.au=Antonellis%2C+Anthony%3BLee-Lin%2C+Shih-Queen%3BMaduro%2C+Valerie%3BWasterlain%2C+Amy%3BFischbeck%2C+Kenneth%3BGreen%2C+Eric&rft.aulast=Antonellis&rft.aufirst=Anthony&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Etiology of Autism: A Review T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39221680; 4312852 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Manjunatha, K AU - Chetan, G AU - Venkatesh, H AU - Roy, Siddharth AU - Balu, Sam AU - Venkataswamy, E Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Reviews KW - Etiology KW - Autism KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39221680?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=Genetic+Etiology+of+Autism%3A+A+Review&rft.au=Manjunatha%2C+K%3BChetan%2C+G%3BVenkatesh%2C+H%3BRoy%2C+Siddharth%3BBalu%2C+Sam%3BVenkataswamy%2C+E&rft.aulast=Manjunatha&rft.aufirst=K&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gene Expression Profiling of Murine Spermatogenesis Leads to the Cloning and Characterization of Ard2, a novel mouse ARD1 Homologue that is Preferentially Expressed Starting from Meiosis T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39220636; 4312669 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Pang, Lap-Yin AU - Peacock, Stephanie AU - Johnson, Warren AU - Bear, Deborah AU - Dym, Martin AU - Rennert, Owen AU - Chan, Wai-Yee Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Gene expression KW - Spermatogenesis KW - Meiosis KW - Profiling KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39220636?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=Gene+Expression+Profiling+of+Murine+Spermatogenesis+Leads+to+the+Cloning+and+Characterization+of+Ard2%2C+a+novel+mouse+ARD1+Homologue+that+is+Preferentially+Expressed+Starting+from+Meiosis&rft.au=Pang%2C+Lap-Yin%3BPeacock%2C+Stephanie%3BJohnson%2C+Warren%3BBear%2C+Deborah%3BDym%2C+Martin%3BRennert%2C+Owen%3BChan%2C+Wai-Yee&rft.aulast=Pang&rft.aufirst=Lap-Yin&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - DNA Polymerase Gamma Mutant Proteins have Different Enzymatic Properties but are Associated with the same Mitochondrial Diseases T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39212780; 4312742 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Chan, Sherine AU - Longley, Matthew AU - Copeland, William Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Mutants KW - Mitochondria KW - DNA-directed DNA polymerase KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212780?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=DNA+Polymerase+Gamma+Mutant+Proteins+have+Different+Enzymatic+Properties+but+are+Associated+with+the+same+Mitochondrial+Diseases&rft.au=Chan%2C+Sherine%3BLongley%2C+Matthew%3BCopeland%2C+William&rft.aulast=Chan&rft.aufirst=Sherine&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - NRG1 and the Risk of Schizophrenia: Does it Depend on Statistical Epistasis between NRG1 Protein-Interaction Partners ERBb4, CHRNA7, AKT1, DLG4, CAPON and NOS1? T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39212066; 4312585 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Nicodemus, Kristin AU - Kolachana, Bhaskar AU - Vakkalanka, Radhakrishna AU - Straub, Richard AU - Egan, Michael AU - Weinberger, Daniel Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - AKT1 protein KW - Epistasis KW - Schizophrenia KW - ErbB-2 protein KW - Statistics KW - Mental disorders KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39212066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=NRG1+and+the+Risk+of+Schizophrenia%3A+Does+it+Depend+on+Statistical+Epistasis+between+NRG1+Protein-Interaction+Partners+ERBb4%2C+CHRNA7%2C+AKT1%2C+DLG4%2C+CAPON+and+NOS1%3F&rft.au=Nicodemus%2C+Kristin%3BKolachana%2C+Bhaskar%3BVakkalanka%2C+Radhakrishna%3BStraub%2C+Richard%3BEgan%2C+Michael%3BWeinberger%2C+Daniel&rft.aulast=Nicodemus&rft.aufirst=Kristin&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What is Familial About Familial Bipolar Affective Disorder? Resemblance among Relatives Across a Broad Spectrum of Phenotypic Characteristics T2 - 11th International Congress of Human Genetics (ICHG 2006) AN - 39203038; 4312967 JF - 11th International Congress of Human Genetics (ICHG 2006) AU - Schulze, Thomas AU - Hedeker, Don AU - Zandi, Peter AU - Rietschel, Marcella AU - McMahon, Francis Y1 - 2006/08/06/ PY - 2006 DA - 2006 Aug 06 KW - Affective disorders KW - Phenotypes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39203038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.atitle=What+is+Familial+About+Familial+Bipolar+Affective+Disorder%3F+Resemblance+among+Relatives+Across+a+Broad+Spectrum+of+Phenotypic+Characteristics&rft.au=Schulze%2C+Thomas%3BHedeker%2C+Don%3BZandi%2C+Peter%3BRietschel%2C+Marcella%3BMcMahon%2C+Francis&rft.aulast=Schulze&rft.aufirst=Thomas&rft.date=2006-08-06&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=11th+International+Congress+of+Human+Genetics+%28ICHG+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.ichg2006.com/grid.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Comparison of Cognitive Functioning in Medicated and Unmedicated Subjects with Bipolar Depression T2 - 2nd Biennial Regional Group Conference of the International Society for Bipolar Disorders (ISBD 2006) AN - 40188501; 4331611 JF - 2nd Biennial Regional Group Conference of the International Society for Bipolar Disorders (ISBD 2006) AU - Holmes, M Kathleen AU - Erickson, Kristine AU - Luckenbaugh, David A AU - Drevets, Wayne C AU - Bain, Earle E AU - Cannon, Dara M AU - Snow, Joseph AU - Sahakian, Barabara J AU - Manji, Husseini K AU - Zarate, Carlos A Y1 - 2006/08/02/ PY - 2006 DA - 2006 Aug 02 KW - Depression KW - Cognitive ability UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40188501?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2nd+Biennial+Regional+Group+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2006%29&rft.atitle=A+Comparison+of+Cognitive+Functioning+in+Medicated+and+Unmedicated+Subjects+with+Bipolar+Depression&rft.au=Holmes%2C+M+Kathleen%3BErickson%2C+Kristine%3BLuckenbaugh%2C+David+A%3BDrevets%2C+Wayne+C%3BBain%2C+Earle+E%3BCannon%2C+Dara+M%3BSnow%2C+Joseph%3BSahakian%2C+Barabara+J%3BManji%2C+Husseini+K%3BZarate%2C+Carlos+A&rft.aulast=Holmes&rft.aufirst=M&rft.date=2006-08-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2nd+Biennial+Regional+Group+Conference+of+the+International+Society+for+Bipolar+Disorders+%28ISBD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.kenes.com/isbd/program/SessionIndex.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Child vocabulary across the second year: Stability and continuity for reporter comparisons and a cumulative score AN - 85679056; 200714006 AB - Mothers, fathers and caregivers in 29 families completed the Infant and Toddler Forms of Dutch adaptations of the MacArthur Communicative Development Inventories (CDI) for the same children at 1;1 and 1;8, respectively. We computed CDI Cumulative Scores, which credit the child with the best score for each item on the CDI as checked by any single reporter. We then computed comprehension and production scores for each reporter and for the cumulative score. Different reporters assess a particular child's communicative abilities differently. Mothers', fathers' and caregivers' comprehension scores intercorrelated, as did their production scores. Reporters' comprehension and production scores were lower than their respective cumulative comprehension and production scores. For all reporters and the cumulative score, we found significant stability in comprehension and production from 1;1 to 1;8 and significant increases in average comprehension and production. [Reprinted by permission of Sage Publications, Ltd., copyright 2006.] JF - First Language AU - Bornstein, Marc H AU - Putnick, Diane L AU - De Houwer, Annick AD - National Institute of Child Health and Human Development, Bethesda, MD Marc_H_Bornstein@nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 299 EP - 316 VL - 26 IS - 3 SN - 0142-7237, 0142-7237 KW - Dutch (20100) KW - Infants (35660) KW - Language Acquisition (41600) KW - Parents (62770) KW - Lexicon (47150) KW - Measures (Instruments) (52300) KW - article KW - 4015: psycholinguistics; child language acquisition UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85679056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Allba&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=First+Language&rft.atitle=Child+vocabulary+across+the+second+year%3A+Stability+and+continuity+for+reporter+comparisons+and+a+cumulative+score&rft.au=Bornstein%2C+Marc+H%3BPutnick%2C+Diane+L%3BDe+Houwer%2C+Annick&rft.aulast=Bornstein&rft.aufirst=Marc&rft.date=2006-08-01&rft.volume=26&rft.issue=3&rft.spage=299&rft.isbn=&rft.btitle=&rft.title=First+Language&rft.issn=01427237&rft_id=info:doi/ LA - English DB - Linguistics and Language Behavior Abstracts (LLBA) N1 - Date revised - 2009-04-01 N1 - Last updated - 2016-09-27 N1 - CODEN - FILAE2 N1 - SubjectsTermNotLitGenreText - Infants (35660); Lexicon (47150); Language Acquisition (41600); Measures (Instruments) (52300); Parents (62770); Dutch (20100) ER - TY - JOUR T1 - Long term survival in subacute sclerosing panencephalitis: an enigma. AN - 85398645; pmid-16554134 AB - Subacute sclerosing panencephalitis (SSPE) usually has a progressive stereotypic downhill course and results in premature death. Long-term stabilization or remission is exceptional.To analyze the profile of patients with a relatively 'benign' course who survive beyond 3 years.Descriptive analysis of 19 (16 male, 3 females)/307 (6.2%) patients with benign course who were evaluated at NIMHANS between January 1995 and December 2004. Their diagnosis was based on characteristic myoclonic jerks, elevated antibody titers against measles virus in CSF and periodic complexes in EEG.The mean age at onset of symptoms was 11.7+/-3.9 years and mean duration of follow-up from first symptom was 5.9+/-3.1 years (3-13.8 years). Their initial symptoms were seizures (7), myoclonus (6), visual disturbances (4), behavioral changes (1) and cognitive impairment (1). These patients had varied clinical course: stabilization in different stages for 6 months to 5 years (13), remissions for 6 months to 9 years and reversal of staging with functional recovery from being bed bound to ambulant (8). Their diagnosis was often delayed. Small sample size did not permit to analyze the influence of possible disease modifying agents used in 10 patients (isoprenosine-3, amantidine-4, oral steroids-4, methylprednisolone-1, intravenous immunoglobulin-1).Our observations suggest that SSPE may have a highly variable clinical course and warrants cautious approach for counseling at initial evaluation and while interpreting beneficial effect of disease modifying agent(s). There is a need to explore prognostic marker(s). JF - Brain & development AU - Prashanth, L K AU - Taly, A B AU - Ravi, V AU - Sinha, S AU - Rao, S AD - Department of Neurology, National Institute of Mental Health and Neurosciences, NIMHANS, Bangalore 560029, Karnataka, India. Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 447 EP - 452 VL - 28 IS - 7 SN - 0387-7604, 0387-7604 KW - Index Medicus KW - National Library of Medicine KW - Adolescent KW - Adult KW - Antibodies, Viral: metabolism KW - Child KW - Child, Preschool KW - Demography KW - Female KW - Humans KW - Longitudinal Studies KW - Male KW - Myoclonus: physiopathology KW - Neurologic Examination: methods KW - Retrospective Studies KW - *Subacute Sclerosing Panencephalitis: epidemiology KW - Subacute Sclerosing Panencephalitis: immunology KW - *Subacute Sclerosing Panencephalitis: mortality KW - Subacute Sclerosing Panencephalitis: physiopathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85398645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Brain+%26+development&rft.atitle=Long+term+survival+in+subacute+sclerosing+panencephalitis%3A+an+enigma.&rft.au=Prashanth%2C+L+K%3BTaly%2C+A+B%3BRavi%2C+V%3BSinha%2C+S%3BRao%2C+S&rft.aulast=Prashanth&rft.aufirst=L&rft.date=2006-08-01&rft.volume=28&rft.issue=7&rft.spage=447&rft.isbn=&rft.btitle=&rft.title=Brain+%26+development&rft.issn=03877604&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Cochleosaccular dysplasia associated with a connexin 26 mutation in keratitis-ichthyosis-deafness syndrome. AN - 85394267; pmid-16885744 AB - The objective of this study was to characterize the temporal bone phenotype associated with a mutation of GJB2 (encoding connexin 26).The authors conducted correlative clinical, molecular genetic, and postmortem histopathologic analysis.The study subject was a male infant with keratitis-ichthyosis-deafness (KID) syndrome. We performed a nucleotide sequence analysis of GJB2 and a histopathologic analysis of the temporal bones.The subject was heterozygous for G45E, a previously reported KID syndrome mutation of GJB2. The primary inner ear abnormality was dysplasia of the cochlear and saccular neuroepithelium.GJB2 mutations can cause deafness in KID syndrome, and possibly in other GJB2 mutant phenotypes, by disrupting cochlear differentiation. JF - The Laryngoscope AU - Griffith, Andrew J AU - Yang, Yandan AU - Pryor, Shannon P AU - Park, Hong-Joon AU - Jabs, Ethylin Wang AU - Nadol, Joseph B AU - Russell, Laura J AU - Wasserman, Daniel I AU - Richard, Gabriele AU - Adams, Joe C AU - Merchant, Saumil N AD - Section on Gene Structure and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, USA. Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1404 EP - 1408 VL - 116 IS - 8 SN - 0023-852X, 0023-852X KW - Index Medicus KW - National Library of Medicine KW - *Cochlea: abnormalities KW - *Connexins: genetics KW - *Deafness: genetics KW - Hearing Loss, Sensorineural: genetics KW - Heterozygote KW - Humans KW - Ichthyosis: complications KW - *Ichthyosis: genetics KW - Infant, Newborn KW - Keratitis: complications KW - *Keratitis: genetics KW - Male KW - Mutation KW - *Saccule and Utricle: abnormalities KW - Syndrome KW - Temporal Bone: abnormalities KW - Temporal Bone: pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85394267?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Laryngoscope&rft.atitle=Cochleosaccular+dysplasia+associated+with+a+connexin+26+mutation+in+keratitis-ichthyosis-deafness+syndrome.&rft.au=Griffith%2C+Andrew+J%3BYang%2C+Yandan%3BPryor%2C+Shannon+P%3BPark%2C+Hong-Joon%3BJabs%2C+Ethylin+Wang%3BNadol%2C+Joseph+B%3BRussell%2C+Laura+J%3BWasserman%2C+Daniel+I%3BRichard%2C+Gabriele%3BAdams%2C+Joe+C%3BMerchant%2C+Saumil+N&rft.aulast=Griffith&rft.aufirst=Andrew&rft.date=2006-08-01&rft.volume=116&rft.issue=8&rft.spage=1404&rft.isbn=&rft.btitle=&rft.title=The+Laryngoscope&rft.issn=0023852X&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - SuppNotes - Cites: Am J Hum Genet. 2002 May;70(5):1341-8[11912510]; Cites: Pediatr Dermatol. 2002 May-Jun;19(3):232-6[12047643]; Cites: Curr Biol. 2002 Jul 9;12(13):1106-11[12121617]; Cites: Laryngoscope. 2002 Feb;112(2):272-80[11889383]; Cites: N Engl J Med. 2002 Jan 24;346(4):243-9[11807148]; Cites: Laryngoscope. 2000 Feb;110(2 Pt 1):269-75[10680928]; Cites: Otol Neurotol. 2002 Sep;23(5):789-92[12218636]; Cites: Am J Dermatopathol. 1993 Feb;15(1):64-9[8434734]; Cites: Arch Otolaryngol. 1971 Jan;93(1):68-74[5538743]; Cites: Hum Mol Genet. 2003 May 1;12(9):995-1004[12700168]; Cites: Annu Rev Genomics Hum Genet. 2003;4:341-402[14527306]; Cites: Am J Med Genet A. 2005 Mar 1;133A(2):128-31[15633193]; Cites: J Hum Genet. 2005;50(2):76-83[15700112]; Cites: Ann Otol Rhinol Laryngol. 1992 May;101(5):413-6[1570935] N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Melanized nigral neuronal numbers in Nigerian and British individuals. AN - 85392224; pmid-16673400 AB - The role of genetic and environmental factors in etiopathogenesis of Parkinson's disease (PD) is debated. The prevalence of PD is higher among white than nonwhite populations, yet it is five times higher in nonwhites living in the United States than in Nigeria. We compare counts of melanized nigral neurons between neurologically normal Nigerians and British brains. Neuronal counts were estimated in an age-matched sample of 23 Nigerian and 7 British brains from neurologically normal individuals who had no Lewy bodies and Lewy neurites on alpha-synuclein immunostaining. Two investigators blind to age and ethnicity performed counts of melanized neurons in a single 7-mum hemisections showing the substantia nigra pars compacta. No significant difference exits in the number of neurons between the Nigerian and the British subjects (P = 0.1, NS). Differences in melanized nigral neuronal numbers may not explain differences in the prevalence of PD between white and nonwhite populations, suggesting factors other than neuronal numbers contribute to differential susceptibility of black vs. white races to PD.(c) 2006 Movement Disorder Society JF - Movement disorders : official journal of the Movement Disorder Society AU - Muthane, Uday B AU - Chickabasaviah, Yasha T AU - Henderson, Jasmine AU - Kingsbury, Ann E AU - Kilford, Linda AU - Shankar, Susarla K AU - Subbakrishna, D K AU - Lees, Andrew J AD - Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. umuthane@usa.net Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1239 EP - 1241 VL - 21 IS - 8 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Cell Count KW - Great Britain KW - Humans KW - *Melanins: metabolism KW - Neurons: cytology KW - *Neurons: metabolism KW - Nigeria KW - *Parkinson Disease: metabolism KW - Parkinson Disease: pathology KW - Reference Values KW - *Substantia Nigra: cytology KW - *Substantia Nigra: metabolism KW - alpha-Synuclein: metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85392224?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Melanized+nigral+neuronal+numbers+in+Nigerian+and+British+individuals.&rft.au=Muthane%2C+Uday+B%3BChickabasaviah%2C+Yasha+T%3BHenderson%2C+Jasmine%3BKingsbury%2C+Ann+E%3BKilford%2C+Linda%3BShankar%2C+Susarla+K%3BSubbakrishna%2C+D+K%3BLees%2C+Andrew+J&rft.aulast=Muthane&rft.aufirst=Uday&rft.date=2006-08-01&rft.volume=21&rft.issue=8&rft.spage=1239&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - Biomarker and drug-target discovery using proteomics in a new rat model of sepsis-induced acute renal failure AN - 807265563; 13683007 AB - Sepsis is one of the common causes of acute renal failure (ARF). The objective of this study was to identify new biomarkers and therapeutic targets. We present a new rat model of sepsis-induced ARF based on cecal ligation and puncture (CLP). We used this model to find urinary proteins which may be potential biomarkers and/or drug targets. Aged rats were treated with fluids and antibiotics after CLP. Urinary proteins from septic rats without ARF and urinary proteins from septic rats with ARF were compared by difference in-gel electrophoresis (DIGE). CLP surgery elevated interleukin (IL)-6 and IL-10 serum cytokines and blood nitrite compared with sham-operated rats. However, there was a range of serum creatinine values at 24h (0.4-2.3mg/dl) and only 24% developed ARF. Histology confirmed renal injury in these rats. Forty-nine percent of rats did not develop ARF. Rats without ARF also had less liver injury. The mortality rate at 24h was 27% but was increased by housing the post-surgery rats in metabolic cages. Creatinine clearance and urine output 2-8h after CLP was significantly reduced in rats which died within 24h. Using DIGE we identified changes in a number of urinary proteins including albumin, brush-border enzymes (e.g., meprin-1-alpha) and serine protease inhibitors. The meprin-1-alpha inhibitor actinonin prevented ARF in aged mice. In summary, we describe a new rat model of sepsis-induced ARF which has a heterogeneous response similar to humans. This model allowed us to use DIGE to find changes in urinary proteins and this approach identified a potential biomarker and drug target - meprin-1-alpha.Kidney International (2006) 70, 496-506. doi:10.1038/sj.ki.5001575; published online7 June 2006 JF - Kidney International AU - Holly, M K AU - Dear, J W AU - Hu, X AU - Schechter, A N AU - Gladwin, M T AU - Hewitt, S M AU - Yuen, P S T AU - Star, R A AD - 1 Renal Diagnostics and Therapeutics Unit, NIDDK, Bethesda, Maryland, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 496 EP - 506 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 70 IS - 3 SN - 0085-2538, 0085-2538 KW - Microbiology Abstracts B: Bacteriology KW - Creatinine KW - Injuries KW - Kidney KW - Renal failure KW - Enzymes KW - Drug development KW - biomarkers KW - Drugs KW - Models KW - J 02410:Animal Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/807265563?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Kidney+International&rft.atitle=Biomarker+and+drug-target+discovery+using+proteomics+in+a+new+rat+model+of+sepsis-induced+acute+renal+failure&rft.au=Holly%2C+M+K%3BDear%2C+J+W%3BHu%2C+X%3BSchechter%2C+A+N%3BGladwin%2C+M+T%3BHewitt%2C+S+M%3BYuen%2C+P+S+T%3BStar%2C+R+A&rft.aulast=Holly&rft.aufirst=M&rft.date=2006-08-01&rft.volume=70&rft.issue=3&rft.spage=496&rft.isbn=&rft.btitle=&rft.title=Kidney+International&rft.issn=00852538&rft_id=info:doi/10.1038%2Fsj.ki.5001575 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Creatinine; Injuries; Kidney; Enzymes; Renal failure; Drug development; Drugs; biomarkers; Models DO - http://dx.doi.org/10.1038/sj.ki.5001575 ER - TY - JOUR T1 - Validity and reliability of a new food frequency questionnaire compared to 24h recalls and biochemical measurements: pilot phase of Golestan cohort study of esophageal cancer AN - 754897530; 13523092 AB - Background:A pilot study was carried out to evaluate validity and reproducibility of a food frequency questionnaire (FFQ), which was designed to be used in a prospective cohort study in a population at high risk for esophageal cancer in northern Iran. Methods:The FFQ was administered four times to 131 subjects, aged 35-65 years, of both sexes. Twelve 24-h dietary recalls for two consecutive days were administered monthly during 1 year and used as a reference method. The excretion of nitrogen was measured on four 24-h urine samples, and plasma levels of beta -carotene, retinol, vitamin C and alpha -tocopherol was measured from two time points. Relative validity of FFQ and 24-h diet recall was assessed by comparing nutrient intake derived from both methods with the urinary nitrogen and plasma levels of beta -carotene, retinol, vitamin C and alpha -tocopherol. Results:Correlation coefficients comparing energy and nutrients intake based on the mean of the four FFQ and the mean of twelve 24-h diet recalls were 0.75 for total energy, 0.75 for carbohydrates, 0.76 for proteins and 0.65 for fat. Correlation coefficients between the FFQ-based intake and serum levels of beta -carotene, retinol, vitamin C and vitamin E/ alpha -tocopherol were 0.37, 0.32, 0.35 and 0.06, respectively. Correlation coefficients between urinary nitrogen and FFQ-based protein intake ranged from 0.23 to 0.35. Intraclass correlation coefficients used to measure reproducibility of FFQ ranged from 0.66 to 0.89. Conclusion:We found that the FFQ provides valid and reliable measurements of habitual intake for energy and most of the nutrients studied.European Journal of Clinical Nutrition (2006) 60, 971-977. doi:10.1038/sj.ejcn.1602407; published online 8 February 2006 JF - European Journal of Clinical Nutrition AU - Malekshah, A F AU - Kimiagar, M AU - Saadatian-Elahi, M AU - Pourshams, A AU - Nouraie, M AU - Goglani, G AU - Hoshiarrad, A AU - Sadatsafavi, M AU - Golestan, B AU - Yoonesi, A AU - Rakhshani, N AU - Fahimi, S AU - Nasrollahzadeh, D AU - Salahi, R AU - Ghafarpour, A AU - Semnani, S AU - Steghens, J P AU - Abnet, C C AU - Kamangar, F AU - Dawsey, S M AU - Brennan, P AU - Boffetta, P AU - Malekzadeh, R AD - 6 Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 971 EP - 977 PB - Nature Publishing Group VL - 60 IS - 8 SN - 0954-3007, 0954-3007 KW - Risk Abstracts UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754897530?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+Journal+of+Clinical+Nutrition&rft.atitle=Validity+and+reliability+of+a+new+food+frequency+questionnaire+compared+to+24h+recalls+and+biochemical+measurements%3A+pilot+phase+of+Golestan+cohort+study+of+esophageal+cancer&rft.au=Malekshah%2C+A+F%3BKimiagar%2C+M%3BSaadatian-Elahi%2C+M%3BPourshams%2C+A%3BNouraie%2C+M%3BGoglani%2C+G%3BHoshiarrad%2C+A%3BSadatsafavi%2C+M%3BGolestan%2C+B%3BYoonesi%2C+A%3BRakhshani%2C+N%3BFahimi%2C+S%3BNasrollahzadeh%2C+D%3BSalahi%2C+R%3BGhafarpour%2C+A%3BSemnani%2C+S%3BSteghens%2C+J+P%3BAbnet%2C+C+C%3BKamangar%2C+F%3BDawsey%2C+S+M%3BBrennan%2C+P%3BBoffetta%2C+P%3BMalekzadeh%2C+R&rft.aulast=Malekshah&rft.aufirst=A&rft.date=2006-08-01&rft.volume=60&rft.issue=8&rft.spage=971&rft.isbn=&rft.btitle=&rft.title=European+Journal+of+Clinical+Nutrition&rft.issn=09543007&rft_id=info:doi/10.1038%2Fsj.ejcn.1602407 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-09-01 N1 - Last updated - 2011-12-14 DO - http://dx.doi.org/10.1038/sj.ejcn.1602407 ER - TY - JOUR T1 - Balance between Dopamine and Serotonin Release Modulates Behavioral Effects of Amphetamine-Type Drugs AN - 745932877; 7220688 AB - The abuse of illicit stimulants is a worldwide crisis, yet few medicines are available for treating stimulant addiction. We have advocated the idea of 'agonist therapy' for cocaine dependence. This strategy involves administration of stimulant-like medications (e.g., monoamine releasers) to alleviate cocaine withdrawal symptoms and prevent relapse. A chief limitation of this strategy is that many candidate medicines possess high abuse liability due to activation of mesolimbic dopamine (DA) neurons in reward pathways. Evidence suggests that serotonin (5-HT) neurons can provide an inhibitory influence over mesolimbic DA neurons. Thus, it might be predicted that the balance between DA and 5-HT transmission is a critical variable when developing medications with reduced stimulant side effects. In this article, we review recent studies from our laboratory that examined neurochemical and behavioral effects of a series of monoamine releasers which displayed different potencies at DA and 5-HT transporters. The data show that increasing 5-HT release can attenuate stimulant effects mediated by DA release, such as motor stimulation and drug self-administration. Our findings support the work of others and indicate that elevated synaptic 5-HT can dampen certain behavioral effects of DA-releasing agents. Moreover, the relationship between DA and 5-HT releasing potency is an important determinant in developing new agonist medications with reduced stimulant properties. JF - Annals of the New York Academy of Sciences AU - Rothman, Richard B AU - Baumann, Michael H AD - Address for correspondence: Richard B. Rothman, M.D., Ph.D., CPS, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224. Voice: 410-550-1487, rrothman@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 245 EP - 260 PB - New York Academy of Sciences, 2 East 63rd Street New York NY 10021 USA, [mailto:publications@nyas.org], [URL:http://www.nyas.org] VL - 1074 IS - 1 SN - 0077-8923, 0077-8923 KW - Health & Safety Science Abstracts KW - cocaine KW - Reviews KW - crises KW - Liability KW - Drugs KW - Side effects KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/745932877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Balance+between+Dopamine+and+Serotonin+Release+Modulates+Behavioral+Effects+of+Amphetamine-Type+Drugs&rft.au=Rothman%2C+Richard+B%3BBaumann%2C+Michael+H&rft.aulast=Rothman&rft.aufirst=Richard&rft.date=2006-08-01&rft.volume=1074&rft.issue=1&rft.spage=245&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/10.1196%2Fannals.1369.064 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-07-01 N1 - SuppNotes - Figures, 8; tables, 1; references, 59. N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Reviews; cocaine; crises; Liability; Drugs; Side effects DO - http://dx.doi.org/10.1196/annals.1369.064 ER - TY - JOUR T1 - Transfer of the AQP1 cDNA for the correction of radiation-induced salivary hypofunction. AN - 68863847; 16368071 AB - The treatment of most patients with head and neck cancer includes ionizing radiation (IR). Salivary glands in the IR field suffer significant and irreversible damage, leading to considerable morbidity. Previously, we reported that adenoviral (Ad)-mediated transfer of the human aquaporin-1 (hAQP1) cDNA to rat [C. Delporte, B.C. O'Connell, X. He, H.E. Lancaster, A.C. O'Connell, P. Agre, B.J. Baum, Increased fluid secretion after adenoviral-mediated transfer of the aquaporin-1 cDNA to irradiated rat salivary glands. Proc. Natl. Acad. Sci. U S A. 94 (1997) 3268-3273] and miniature pig [Z. Shan, J. Li, C. Zheng, X. Liu, Z. Fan, C. Zhang, C.M. Goldsmith, R.B. Wellner, B.J Baum, S. Wang. Increased fluid secretion after adenoviral-mediated transfer of the human aquaporin-1 cDNA to irradiated miniature pig parotid glands. Mol. Ther. 11 (2005) 444-451] salivary glands approximately 16 weeks following IR resulted in a dose-dependent increase in salivary flow to > or =80% control levels on day 3. A control Ad vector was without any significant effect on salivary flow. Additionally, after administration of Ad vectors to salivary glands, no significant lasting effects were observed in multiple measured clinical chemistry and hematology values. Taken together, the findings show that localized delivery of AdhAQP1 to IR-damaged salivary glands is useful in transiently increasing salivary secretion in both small and large animal models, without significant general adverse events. Based on these results, we are developing a clinical trial to test if the hAQP1 cDNA transfer strategy will be clinically effective in restoring salivary flow in patients with IR-induced parotid hypofunction. JF - Biochimica et biophysica acta AU - Baum, Bruce J AU - Zheng, Changyu AU - Cotrim, Ana P AU - Goldsmith, Corinne M AU - Atkinson, Jane C AU - Brahim, Jaime S AU - Chiorini, John A AU - Voutetakis, Antonis AU - Leakan, Rose Anne AU - Van Waes, Carter AU - Mitchell, James B AU - Delporte, Christine AU - Wang, Songlin AU - Kaminsky, Stephen M AU - Illei, Gabor G AD - Gene Therapy and Therapeutics Branch, Bethesda, MD 20892-1190, USA. bbaum@dir.nidcr.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1071 EP - 1077 VL - 1758 IS - 8 SN - 0006-3002, 0006-3002 KW - DNA, Complementary KW - 0 KW - Aquaporin 1 KW - 146410-94-8 KW - Index Medicus KW - Swine KW - Rats KW - Animals KW - Parotid Gland -- physiopathology KW - Gene Transfer Techniques KW - Humans KW - Genetic Vectors KW - Parotid Gland -- radiation effects KW - Swine, Miniature KW - Salivary Glands -- radiation effects KW - Salivary Glands -- physiopathology KW - Radiation Injuries, Experimental -- therapy KW - DNA, Complementary -- genetics KW - Aquaporin 1 -- metabolism KW - Aquaporin 1 -- genetics KW - Salivary Gland Diseases -- therapy KW - Head and Neck Neoplasms -- radiotherapy KW - Genetic Therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68863847?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochimica+et+biophysica+acta&rft.atitle=Transfer+of+the+AQP1+cDNA+for+the+correction+of+radiation-induced+salivary+hypofunction.&rft.au=Baum%2C+Bruce+J%3BZheng%2C+Changyu%3BCotrim%2C+Ana+P%3BGoldsmith%2C+Corinne+M%3BAtkinson%2C+Jane+C%3BBrahim%2C+Jaime+S%3BChiorini%2C+John+A%3BVoutetakis%2C+Antonis%3BLeakan%2C+Rose+Anne%3BVan+Waes%2C+Carter%3BMitchell%2C+James+B%3BDelporte%2C+Christine%3BWang%2C+Songlin%3BKaminsky%2C+Stephen+M%3BIllei%2C+Gabor+G&rft.aulast=Baum&rft.aufirst=Bruce&rft.date=2006-08-01&rft.volume=1758&rft.issue=8&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Biochimica+et+biophysica+acta&rft.issn=00063002&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-09-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prenatal exposure to 1,1-dichloro-2,2-bis (p-chlorophenyl)ethylene (p,p'-DDE) in relation to child growth. AN - 68792175; 16606643 AB - To examine the relation between prenatal 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) exposure (a metabolite of the insecticide DDT) and child growth during the first 7 years of life. Design Prospective cohort study. Participants 1,712 children born between 1959 and 1966 with measured p,p'-DDE concentrations in their mother's serum samples from pregnancy. Setting Multicenter US Collaborative Perinatal Project (CPP). The highest prenatal concentrations of p,p'-DDE (>or=60 microg/l), as compared with the lowest (<15 microg/l), were associated with decreased height at age 1 year [adjusted coefficient (SE) = -0.72 cm (0.37), n = 1,540], 4 years [-1.14 cm (0.56), n = 1,289], and 7 years [-2.19 (0.46), n = 1,371]. Among subjects in lower categories of exposure no association was observed. The findings suggest that high prenatal exposure to p,p'-DDE decreases height in children. Impaired growth may be a general indicator of toxicity and suggests that specific organ systems (e.g. endocrine) could be affected. JF - International journal of epidemiology AU - Ribas-Fitó, Núria AU - Gladen, Beth C AU - Brock, John W AU - Klebanoff, Mark A AU - Longnecker, Matthew P AD - Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, USA. nribas@imim.es Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 853 EP - 858 VL - 35 IS - 4 SN - 0300-5771, 0300-5771 KW - Environmental Pollutants KW - 0 KW - Insecticides KW - Dichlorodiphenyl Dichloroethylene KW - 4M7FS82U08 KW - Index Medicus KW - Sex Factors KW - Humans KW - Linear Models KW - African Americans KW - Child KW - Maternal Exposure KW - Pregnancy KW - Child, Preschool KW - Infant KW - Prospective Studies KW - European Continental Ancestry Group KW - Adult KW - Case-Control Studies KW - Body Height -- drug effects KW - Female KW - Male KW - Insecticides -- toxicity KW - Environmental Pollutants -- toxicity KW - Dichlorodiphenyl Dichloroethylene -- toxicity KW - Growth -- drug effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68792175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+epidemiology&rft.atitle=Prenatal+exposure+to+1%2C1-dichloro-2%2C2-bis+%28p-chlorophenyl%29ethylene+%28p%2Cp%27-DDE%29+in+relation+to+child+growth.&rft.au=Ribas-Fit%C3%B3%2C+N%C3%BAria%3BGladen%2C+Beth+C%3BBrock%2C+John+W%3BKlebanoff%2C+Mark+A%3BLongnecker%2C+Matthew+P&rft.aulast=Ribas-Fit%C3%B3&rft.aufirst=N%C3%BAria&rft.date=2006-08-01&rft.volume=35&rft.issue=4&rft.spage=853&rft.isbn=&rft.btitle=&rft.title=International+journal+of+epidemiology&rft.issn=03005771&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-07-13 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Int J Epidemiol. 2006 Aug;35(4):858-61 [16847017] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Occupational exposures and head and neck cancers among Swedish construction workers. AN - 68789278; 16932824 AB - Occupational exposures in the construction industry may increase the risk of head and neck cancers, although the epidemiologic evidence is limited by problems of low study power and inadequate adjustment for tobacco use. In an attempt to address this issue, the relationship between selected occupational exposures and head and neck cancer risk was investigated using data from a large cohort of Swedish construction workers. Altogether 510 squamous cell carcinomas of the head and neck (171 in the oral cavity, 112 in the pharynx, 227 in the larynx) were identified during 1971-2001 among 307 799 male workers in the Swedish construction industry. Exposure to diesel exhaust, asbestos, organic solvents, metal dust, asphalt, wood dust, stone dust, mineral wool, and cement dust was assessed using a semi-quantitative job-exposure matrix. Rate ratios (RR) and 95% confidence intervals (95% CI) were calculated for head and neck cancers in relation to occupational exposure, using Poisson regression with adjustment for age and smoking status. Asbestos exposure was related to an increased laryngeal cancer incidence (RR 1.9, 95% CI 1.2-3.1). Excesses of pharyngeal cancer were observed among workers exposed to cement dust (RR 1.9, 95% CI 1.2-3.1). No occupational exposures were associated with oral cavity cancer. These findings did not materially change upon additional adjustment for cigarette pack-years. These findings offer further evidence that asbestos increases the risk of laryngeal cancer. The observation of a positive association between cement dust exposure and pharyngeal cancer warrants further investigation. JF - Scandinavian journal of work, environment & health AU - Purdue, Mark P AU - Järvholm, Bengt AU - Bergdahl, Ingvar A AU - Hayes, Richard B AU - Baris, Dalsu AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd, EPS 8111, Rockville, MD 20852, USA. purduem@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 270 EP - 275 VL - 32 IS - 4 SN - 0355-3140, 0355-3140 KW - Dust KW - 0 KW - Asbestos KW - 1332-21-4 KW - Index Medicus KW - Pharyngeal Neoplasms -- etiology KW - Humans KW - Smoking -- adverse effects KW - Aged KW - Laryngeal Neoplasms -- epidemiology KW - Laryngeal Neoplasms -- etiology KW - Adult KW - Cohort Studies KW - Sweden -- epidemiology KW - Asbestos -- adverse effects KW - Middle Aged KW - Occupations KW - Male KW - Carcinoma, Squamous Cell -- etiology KW - Carcinoma, Squamous Cell -- epidemiology KW - Head and Neck Neoplasms -- etiology KW - Construction Materials -- adverse effects KW - Occupational Diseases -- etiology KW - Occupational Exposure -- adverse effects KW - Occupational Diseases -- epidemiology KW - Head and Neck Neoplasms -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68789278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+journal+of+work%2C+environment+%26+health&rft.atitle=Occupational+exposures+and+head+and+neck+cancers+among+Swedish+construction+workers.&rft.au=Purdue%2C+Mark+P%3BJ%C3%A4rvholm%2C+Bengt%3BBergdahl%2C+Ingvar+A%3BHayes%2C+Richard+B%3BBaris%2C+Dalsu&rft.aulast=Purdue&rft.aufirst=Mark&rft.date=2006-08-01&rft.volume=32&rft.issue=4&rft.spage=270&rft.isbn=&rft.btitle=&rft.title=Scandinavian+journal+of+work%2C+environment+%26+health&rft.issn=03553140&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-16 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. AN - 68788344; 16930414 AB - Induction of the immediate early gene protein product Fos has been used extensively to assess neural activation in the striatum after repeated cocaine administration to rats in their home cages but rarely after repeated administration outside the home cage, which produces more robust locomotor sensitization. In the present study, we found cocaine-induced Fos expression in nucleus accumbens, but not caudate-putamen, was enhanced 1 and 6 months after repeated drug administration in locomotor activity chambers. Double-labelling of Fos protein and enkephalin mRNA indicated that Fos expression in nucleus accumbens was enhanced in enkephalin-positive, but not enkephalin-negative, medium spiny neurons. In contrast, cocaine-induced Fos expression was absent altogether in nucleus accumbens and unaltered in caudate-putamen 1 month after repeated cocaine administration in the home cage. As cocaine-induced locomotor activity was also enhanced 1 and 6 months after repeated cocaine administration in locomotor activity chambers, we wanted to confirm that neuronal activity in nucleus accumbens mediates cocaine-induced locomotor activity using our particular treatment regimen. Bilateral infusions of the GABA agonists baclofen and muscimol (1 microg/side) into nucleus accumbens of sensitized rats blocked cocaine-induced Fos expression and locomotor activity. Thus, while neuronal activity in both D1- and D2-type neurons in nucleus accumbens can mediate acute cocaine-induced locomotor activity, the enhanced activation of enkephalinergic D2-type neurons suggests that these latter neurons mediate the enhancement of cocaine-induced locomotor activity for up to 6 months after repeated drug administration outside the home cage. JF - The European journal of neuroscience AU - Hope, Bruce T AU - Simmons, Danielle E AU - Mitchell, Tim B AU - Kreuter, Justin D AU - Mattson, Brandi J AD - Behavioural Neuroscience Branch, Intramural Research Program, The National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. bhope@intra.nida.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 867 EP - 875 VL - 24 IS - 3 SN - 0953-816X, 0953-816X KW - Dopamine Uptake Inhibitors KW - 0 KW - Enkephalins KW - GABA Agonists KW - Proto-Oncogene Proteins c-fos KW - Receptors, Dopamine D2 KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Gene Expression -- drug effects KW - Animals KW - Drug Administration Schedule KW - Dopamine Uptake Inhibitors -- adverse effects KW - Disease Models, Animal KW - Drug Interactions -- physiology KW - Receptors, Dopamine D2 -- metabolism KW - Up-Regulation -- physiology KW - Rats KW - Rats, Sprague-Dawley KW - Neostriatum -- metabolism KW - Time KW - GABA Agonists -- pharmacology KW - Up-Regulation -- drug effects KW - Neostriatum -- drug effects KW - Receptors, Dopamine D2 -- drug effects KW - Enkephalins -- metabolism KW - Gene Expression -- physiology KW - Time Factors KW - Male KW - Proto-Oncogene Proteins c-fos -- drug effects KW - Proto-Oncogene Proteins c-fos -- metabolism KW - Nucleus Accumbens -- drug effects KW - Cocaine-Related Disorders -- physiopathology KW - Nucleus Accumbens -- metabolism KW - Motor Activity -- physiology KW - Motor Activity -- drug effects KW - Nucleus Accumbens -- physiopathology KW - Cocaine-Related Disorders -- metabolism KW - Cocaine -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68788344?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+European+journal+of+neuroscience&rft.atitle=Cocaine-induced+locomotor+activity+and+Fos+expression+in+nucleus+accumbens+are+sensitized+for+6+months+after+repeated+cocaine+administration+outside+the+home+cage.&rft.au=Hope%2C+Bruce+T%3BSimmons%2C+Danielle+E%3BMitchell%2C+Tim+B%3BKreuter%2C+Justin+D%3BMattson%2C+Brandi+J&rft.aulast=Hope&rft.aufirst=Bruce&rft.date=2006-08-01&rft.volume=24&rft.issue=3&rft.spage=867&rft.isbn=&rft.btitle=&rft.title=The+European+journal+of+neuroscience&rft.issn=0953816X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-01 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging. AN - 68785200; 16673357 AB - Ferumoxides-protamine sulfate (FE-Pro) complexes are used for intracellular magnetic labeling of cells to non-invasively monitor cell trafficking by in vivo MRI. FE-Pro labeling is non-toxic to cells; however, the effects of FE-Pro labeling on cellular expression of transferrin receptor (TfR-1) and ferritin, proteins involved in iron transport and storage, has not been reported. FE-Pro-labeled human mesenchymal stem cells (MSCs), HeLa cells and primary macrophages were cultured from 1 week to 2 months and evaluated for TfR-1 and ferritin gene expression by RT-PCR and protein levels were determined using Western blots. MTT (proliferation assay) and reactive oxygen species (ROS) analysis were performed. FE-Pro labeling of HeLa and MSCs resulted in a transient decrease in TfR-1 mRNA and protein levels. In contrast, Fe-Pro labeling of primary macrophages resulted in an increase in TfR-1 mRNA but not in TfR-1 protein levels. Ferritin mRNA and protein levels increased transiently in labeled HeLa and macrophages but were sustained in MSCs. No changes in MTT and ROS analysis were noted. In conclusion, FE-Pro labeling elicited physiological changes of iron metabolism or storage, validating the safety of this procedure for cellular tracking by MRI. JF - NMR in biomedicine AU - Pawelczyk, Edyta AU - Arbab, Ali S AU - Pandit, Sunil AU - Hu, Elbert AU - Frank, Joseph A AD - Laboratory of Diagnostic Radiology Research, Experimental Neuroimaging Section, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. pawelczyke@cc.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 581 EP - 592 VL - 19 IS - 5 SN - 0952-3480, 0952-3480 KW - Dextrans KW - 0 KW - Indicators and Reagents KW - Magnetite Nanoparticles KW - Oxides KW - Protamines KW - Reactive Oxygen Species KW - Receptors, Transferrin KW - Ferritins KW - 9007-73-2 KW - Iron KW - E1UOL152H7 KW - ferumoxides KW - G6N3J05W84 KW - Ferrosoferric Oxide KW - XM0M87F357 KW - Index Medicus KW - Macrophages -- cytology KW - Reactive Oxygen Species -- metabolism KW - Indicators and Reagents -- metabolism KW - HeLa Cells KW - Humans KW - Cell Differentiation KW - Mesenchymal Stromal Cells -- metabolism KW - Cell Proliferation KW - Cell Survival KW - Cells, Cultured KW - Mesenchymal Stromal Cells -- cytology KW - Macrophages -- metabolism KW - Oxides -- metabolism KW - Magnetic Resonance Imaging -- methods KW - Ferritins -- metabolism KW - Receptors, Transferrin -- genetics KW - Protamines -- metabolism KW - Ferritins -- genetics KW - Iron -- metabolism KW - Receptors, Transferrin -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68785200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NMR+in+biomedicine&rft.atitle=Expression+of+transferrin+receptor+and+ferritin+following+ferumoxides-protamine+sulfate+labeling+of+cells%3A+implications+for+cellular+magnetic+resonance+imaging.&rft.au=Pawelczyk%2C+Edyta%3BArbab%2C+Ali+S%3BPandit%2C+Sunil%3BHu%2C+Elbert%3BFrank%2C+Joseph+A&rft.aulast=Pawelczyk&rft.aufirst=Edyta&rft.date=2006-08-01&rft.volume=19&rft.issue=5&rft.spage=581&rft.isbn=&rft.btitle=&rft.title=NMR+in+biomedicine&rft.issn=09523480&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-22 N1 - Date created - 2006-08-25 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression. AN - 68784645; 16568437 AB - Prior work has shown that chronic cadmium exposed rat liver epithelial cells (CCE-LE) become malignantly transformed after protracted low level cadmium exposure. Acquisition of apoptotic resistance is common in oncogenesis and the present work explores this possibility in CCE-LE cells. CCE-LE cells were resistant to apoptosis induced by etoposide or an acute high concentration of cadmium as assessed by flow cytometry with annexin/FITC. Three key mitogen-activated protein kinases (MAPKs), namely ERK1/2, JNK1/2, and p38, were phosphorylated in CCE-LE cells after acute cadmium exposure. However, the levels of phosphorylated JNK1/2 were markedly decreased in CCE-LE cells compared to control. JNK kinase activity was also suppressed in CCE-LE cells exposed to cadmium. Epidermal growth factor (EGF), used as a positive control for stimulating JNK phosphorylation, was much less effective in CCE-LE cells than control cells. Ro318220 (Ro), a strong activator of JNK, increased phosphorylated JNK1/2 to levels similar to the cadmium-treated control cells and also enhanced apoptosis in response to cadmium in CCE-LE cells. Metallothionein (MT), which is thought to potentially inhibit apoptosis, was strongly overexpressed in CCE-LE cells. Further, in MT knockout (MT-/-) fibroblasts, JNK1/2 phosphorylation was markedly increased after cadmium exposure compared with similarly treated wild-type (MT+/+) cells. These results indicate cadmium-transformed cells acquired apoptotic resistance, which may be linked to the specific suppression of the JNK pathway and is associated with MT overexpression, which, in turn, may impact this signal transduction pathway. The acquisition of apoptotic resistance may play an important role in cadmium carcinogenesis by contributing to both tumor initiation and malignant progression. JF - Molecular carcinogenesis AU - Qu, Wei AU - Fuquay, Richard AU - Sakurai, Teruaki AU - Waalkes, Michael P AD - Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, National Cancer Institute at the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 561 EP - 571 VL - 45 IS - 8 SN - 0899-1987, 0899-1987 KW - Indoles KW - 0 KW - Protein Kinase Inhibitors KW - Cadmium KW - 00BH33GNGH KW - Metallothionein KW - 9038-94-2 KW - Mitogen-Activated Protein Kinase 9 KW - EC 2.7.1.24 KW - JNK Mitogen-Activated Protein Kinases KW - EC 2.7.11.24 KW - Mitogen-Activated Protein Kinase 8 KW - Ro 31-8220 KW - W9A0B5E78O KW - Index Medicus KW - Animals KW - Liver -- pathology KW - Protein Kinase Inhibitors -- pharmacology KW - Mitogen-Activated Protein Kinase 8 -- metabolism KW - Mitogen-Activated Protein Kinase 9 -- metabolism KW - Mitogen-Activated Protein Kinase 9 -- antagonists & inhibitors KW - Rats KW - Mitogen-Activated Protein Kinase 8 -- antagonists & inhibitors KW - Phosphorylation KW - Cells, Cultured KW - Liver -- drug effects KW - Indoles -- pharmacology KW - Up-Regulation KW - Signal Transduction KW - Apoptosis -- genetics KW - Cell Transformation, Neoplastic -- pathology KW - JNK Mitogen-Activated Protein Kinases -- antagonists & inhibitors KW - Cell Transformation, Neoplastic -- metabolism KW - Metallothionein -- antagonists & inhibitors KW - Apoptosis -- drug effects KW - Cell Transformation, Neoplastic -- chemically induced KW - Cadmium -- toxicity KW - Metallothionein -- genetics KW - Metallothionein -- metabolism KW - JNK Mitogen-Activated Protein Kinases -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68784645?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Acquisition+of+apoptotic+resistance+in+cadmium-induced+malignant+transformation%3A+specific+perturbation+of+JNK+signal+transduction+pathway+and+associated+metallothionein+overexpression.&rft.au=Qu%2C+Wei%3BFuquay%2C+Richard%3BSakurai%2C+Teruaki%3BWaalkes%2C+Michael+P&rft.aulast=Qu&rft.aufirst=Wei&rft.date=2006-08-01&rft.volume=45&rft.issue=8&rft.spage=561&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Modulation of the function of the multidrug resistance-linked ATP-binding cassette transporter ABCG2 by the cancer chemopreventive agent curcumin. AN - 68782130; 16928820 AB - Curcumin (curcumin I), demethoxycurcumin (curcumin II), and bisdemethoxycurcumin (curcumin III) are the major forms of curcuminoids found in the turmeric powder, which exhibit anticancer, antioxidant, and anti-inflammatory activities. In this study, we evaluated the ability of purified curcuminoids to modulate the function of either the wild-type 482R or the mutant 482T ABCG2 transporter stably expressed in HEK293 cells and drug-selected MCF-7 FLV1000 and MCF-7 AdVp3000 cells. Curcuminoids inhibited the transport of mitoxantrone and pheophorbide a from ABCG2-expressing cells. However, both cytotoxicity and [(3)H]curcumin I accumulation assays showed that curcuminoids are not transported by ABCG2. Nontoxic concentration of curcumin I, II, and III sensitized the ABCG2-expressing cells to mitoxantrone, topotecan, SN-38, and doxorubicin. This reversal was not due to reduced expression because ABCG2 protein levels were unaltered by treatment with 10 mumol/L curcuminoids for 72 hours. Curcumin I, II, and III stimulated (2.4- to 3.3-fold) ABCG2-mediated ATP hydrolysis and the IC(50)s were in the range of 7.5 to 18 nmol/L, suggesting a high affinity of curcuminoids for ABCG2. Curcuminoids also inhibited the photolabeling of ABCG2 with [(125)I]iodoarylazidoprazosin and [(3)H]azidopine as well as the transport of these two substrates in ABCG2-expressing cells. Curcuminoids did not inhibit the binding of [alpha-(32)P]8-azidoATP to ABCG2, suggesting that they do not interact with the ATP-binding site of the transporter. Collectively, these data show that, among curcuminoids, curcumin I is the most potent modulator of ABCG2 and thus should be considered as a treatment to increase the efficacy of conventional chemotherapeutic drugs. JF - Molecular cancer therapeutics AU - Chearwae, Wanida AU - Shukla, Suneet AU - Limtrakul, Pornngarm AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute/NIH, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1995 EP - 2006 VL - 5 IS - 8 SN - 1535-7163, 1535-7163 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Anticarcinogenic Agents KW - Azides KW - Dihydropyridines KW - Neoplasm Proteins KW - Chlorophyll KW - 1406-65-1 KW - 8-azidoadenosine 5'-triphosphate KW - 53696-59-6 KW - azidopine KW - 63XR70204A KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - azidoprazosin KW - 90990-97-9 KW - Mitoxantrone KW - BZ114NVM5P KW - pheophorbide a KW - IA2WNI2HO2 KW - Curcumin KW - IT942ZTH98 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Prazosin -- metabolism KW - Prazosin -- analogs & derivatives KW - Chlorophyll -- metabolism KW - Mitoxantrone -- metabolism KW - Humans KW - Biological Transport KW - Dihydropyridines -- metabolism KW - Hydrolysis KW - Azides -- metabolism KW - Tumor Cells, Cultured KW - Adenosine Triphosphate -- analogs & derivatives KW - Adenosine Triphosphate -- metabolism KW - Toxicity Tests KW - Chlorophyll -- analogs & derivatives KW - Mutation KW - Neoplasm Proteins -- drug effects KW - ATP-Binding Cassette Transporters -- drug effects KW - Curcumin -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Neoplasm Proteins -- genetics KW - Anticarcinogenic Agents -- pharmacology KW - ATP-Binding Cassette Transporters -- genetics KW - Drug Resistance, Neoplasm KW - Neoplasm Proteins -- metabolism KW - Curcumin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68782130?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Modulation+of+the+function+of+the+multidrug+resistance-linked+ATP-binding+cassette+transporter+ABCG2+by+the+cancer+chemopreventive+agent+curcumin.&rft.au=Chearwae%2C+Wanida%3BShukla%2C+Suneet%3BLimtrakul%2C+Pornngarm%3BAmbudkar%2C+Suresh+V&rft.aulast=Chearwae&rft.aufirst=Wanida&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=1995&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-04 N1 - Date created - 2006-08-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Glucocorticoid amplifies IL-2-dependent expansion of functional FoxP3(+)CD4(+)CD25(+) T regulatory cells in vivo and enhances their capacity to suppress EAE. AN - 68782124; 16841298 AB - IL-2 is crucial for the production of CD4(+)CD25(+) T regulatory (Treg) cells while important for the generation of effective T cell-mediated immunity. How to exploit the capacity of IL-2 to expand Treg cells, while restraining activation of T effector (Teff) cells, is an important and unanswered therapeutic question. Dexamethasone (Dex), a synthetic glucocorticoid steroid, has been reported to suppress IL-2-mediated activation of Teff cells and increase the proportion of Treg cells. Thus, we hypothesized that glucocorticoids may be useful as costimulants to amplify IL-2-mediated selective expansion of Treg cells. We show in this study that short-term simultaneous administration of Dex and IL-2 markedly expanded functional suppressive Foxp3(+)CD4(+)CD25(+) T cells in murine peripheral lymphoid tissues. In a myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE) mouse model, we observed that splenic CD4(+)CD25(+) T cells failed to suppress the proliferation of CD4(+)CD25(-) T cells. Pretreatment with Dex/IL-2 remarkably increased the proportion of CD4(+)FoxP3(+) cells and partially restored the function of splenic CD4(+)CD25(+) T cells, and inhibited the development of EAE. Therefore, the combination of glucocorticoid and IL-2, two currently used therapeutics, may provide a novel approach for the treatment of autoimmune diseases, transplant rejection and graft-vs.-host disease. JF - European journal of immunology AU - Chen, Xin AU - Oppenheim, Joost J AU - Winkler-Pickett, Robin T AU - Ortaldo, John R AU - Howard, O M Zack AD - Basic Research Program, SAIC-Frederick, Center for Cancer Research, National Cancer Institute-Frederick, National Institutes of Health, Frederick, MD 21702, USA. xinc@mail.ncifcrf.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 2139 EP - 2149 VL - 36 IS - 8 SN - 0014-2980, 0014-2980 KW - Forkhead Transcription Factors KW - 0 KW - Foxp3 protein, mouse KW - Glucocorticoids KW - Interleukin-2 KW - Receptors, Interleukin-2 KW - Dexamethasone KW - 7S5I7G3JQL KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Cells, Cultured KW - Disease Models, Animal KW - Mice KW - Female KW - Interleukin-2 -- pharmacology KW - Receptors, Interleukin-2 -- metabolism KW - Forkhead Transcription Factors -- genetics KW - CD4-Positive T-Lymphocytes -- metabolism KW - Encephalomyelitis, Autoimmune, Experimental -- chemically induced KW - Dexamethasone -- pharmacology KW - Encephalomyelitis, Autoimmune, Experimental -- metabolism KW - Forkhead Transcription Factors -- metabolism KW - CD4-Positive T-Lymphocytes -- drug effects KW - Glucocorticoids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68782124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+immunology&rft.atitle=Glucocorticoid+amplifies+IL-2-dependent+expansion+of+functional+FoxP3%28%2B%29CD4%28%2B%29CD25%28%2B%29+T+regulatory+cells+in+vivo+and+enhances+their+capacity+to+suppress+EAE.&rft.au=Chen%2C+Xin%3BOppenheim%2C+Joost+J%3BWinkler-Pickett%2C+Robin+T%3BOrtaldo%2C+John+R%3BHoward%2C+O+M+Zack&rft.aulast=Chen&rft.aufirst=Xin&rft.date=2006-08-01&rft.volume=36&rft.issue=8&rft.spage=2139&rft.isbn=&rft.btitle=&rft.title=European+journal+of+immunology&rft.issn=00142980&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-13 N1 - Date created - 2006-08-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Safety of a 3-weekly schedule of carboplatin plus pegylated liposomal doxorubicin as first line chemotherapy in patients with ovarian cancer: preliminary results of the MITO-2 randomized trial. AN - 68780608; 16882344 AB - The MITO-2 (Multicentre Italian Trials in Ovarian cancer) study is a randomized phase III trial comparing carboplatin plus paclitaxel to carboplatin plus pegylated liposomal doxorubicin in first-line chemotherapy of patients with ovarian cancer. Due to the paucity of published phase I data on the 3-weekly experimental schedule used, an early safety analysis was planned. Patients with ovarian cancer (stage Ic-IV), aged < 75 years, ECOG performance status or=3.0 cm3 were at increased risk for breast cancer [odds ratio (OR), 1.42; 95% confidence interval (95% CI), 1.11-1.70], endometrial cancer (OR, 1.97; 95% CI, 1.12-3.48), and colon cancer (OR, 2.00; 95% CI, 1.25-3.21). Significant trends of risk with increasing volume were found only for breast and endometrial cancers. We conclude that large ovaries among postmenopausal women may represent a marker of risk for hormonally related tumors. Confirmation of these findings in future studies, including analyses of serum hormone levels and tissues, may provide insights into hormonal carcinogenesis among older women. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Sherman, Mark E AU - Lacey, James V AU - Buys, Saundra S AU - Reding, Douglas J AU - Berg, Christine D AU - Williams, Craig AU - Hartge, Patricia AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Boulevard, Rockville, MD 20892, USA. shermanm@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1550 EP - 1554 VL - 15 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Colonic Neoplasms -- etiology KW - Humans KW - Endometrial Neoplasms -- pathology KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Colonic Neoplasms -- pathology KW - Female KW - Endometrial Neoplasms -- etiology KW - Ovarian Neoplasms -- etiology KW - Postmenopause KW - Ovary -- pathology KW - Ovarian Neoplasms -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68719886?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Ovarian+volume%3A+determinants+and+associations+with+cancer+among+postmenopausal+women.&rft.au=Sherman%2C+Mark+E%3BLacey%2C+James+V%3BBuys%2C+Saundra+S%3BReding%2C+Douglas+J%3BBerg%2C+Christine+D%3BWilliams%2C+Craig%3BHartge%2C+Patricia&rft.aulast=Sherman&rft.aufirst=Mark&rft.date=2006-08-01&rft.volume=15&rft.issue=8&rft.spage=1550&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Tobacco use in adult long-term survivors of retinoblastoma. AN - 68719311; 16896033 AB - A significant risk of lung cancer was identified among hereditary, but not nonhereditary, retinoblastoma (Rb) patients. Tobacco use was investigated to determine whether differences in smoking prevalence might explain the lung cancer excess and to characterize smoking patterns in adult survivors of Rb. Subjects were 441 hereditary and 395 nonhereditary 1-year survivors of Rb, age >or=18 years, who responded to a telephone survey about current health behavior, including tobacco use. Response rates were 76% for hereditary and 73% for nonhereditary survivors. We compared patterns and predictors of current tobacco use among hereditary and nonhereditary survivors with other childhood cancer survivor studies and the U.S. population. Hereditary Rb survivors currently smoke cigarettes significantly less frequently than nonhereditary survivors (16. 8% versus 24.3%), although among current smokers, age at smoking initiation (17 years old) and average cigarettes (1.5 packs) smoked daily are similar. Predictors of current and ever cigarette smoking include nonhereditary Rb, older age, being female, less education, and use of other tobacco products. Rb survivors smoke cigarettes significantly less than the U.S. population (rate ratio, 0.63; 95% confidence interval, 0.5-0.8 for males; rate ratio, 0.75; 95% confidence interval, 0.6-0.9 for females), but Rb survivors have comparable smoking rates with other childhood cancer survivors. Smoking did not account for the increased risk of lung cancer among hereditary Rb patients, and this may point to an enhanced sensitivity to the carcinogenic effects of tobacco. Adult survivors of Rb should be encouraged to stop smoking. JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology AU - Foster, Meredith C AU - Kleinerman, Ruth A AU - Abramson, David H AU - Seddon, Johanna M AU - Tarone, Robert E AU - Tucker, Margaret A AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, EPS 7044, 6120 Executive Boulevard, Rockville, MD 20852, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1464 EP - 1468 VL - 15 IS - 8 SN - 1055-9965, 1055-9965 KW - Index Medicus KW - Humans KW - Cohort Studies KW - Adult KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Male KW - Female KW - Retinoblastoma -- mortality KW - Retinal Neoplasms -- mortality KW - Retinal Neoplasms -- epidemiology KW - Survivors KW - Smoking -- epidemiology KW - Retinoblastoma -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68719311?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.atitle=Tobacco+use+in+adult+long-term+survivors+of+retinoblastoma.&rft.au=Foster%2C+Meredith+C%3BKleinerman%2C+Ruth+A%3BAbramson%2C+David+H%3BSeddon%2C+Johanna+M%3BTarone%2C+Robert+E%3BTucker%2C+Margaret+A&rft.aulast=Foster&rft.aufirst=Meredith&rft.date=2006-08-01&rft.volume=15&rft.issue=8&rft.spage=1464&rft.isbn=&rft.btitle=&rft.title=Cancer+epidemiology%2C+biomarkers+%26+prevention+%3A+a+publication+of+the+American+Association+for+Cancer+Research%2C+cosponsored+by+the+American+Society+of+Preventive+Oncology&rft.issn=10559965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Sulindac regulates the aryl hydrocarbon receptor-mediated expression of Phase 1 metabolic enzymes in vivo and in vitro. AN - 68713551; 16531450 AB - Sulindac, a widely used non-steroidal anti-inflammatory drug (NSAID), has been shown to inhibit chemically induced carcinogenesis in animal models. In the present study, we have investigated the molecular mechanism by which sulindac affects the activity and expression of the enzymes that mediate the initial detoxification steps of many environmental carcinogens, the cytochromes P450 1A1, 1A2 and 1B1. Sulindac treatment of Sprague-Dawley rats resulted in a dose-dependent increase in hepatic cytochrome P450 (CYP) enzyme activity and in the expression of hepatic CYPs 1A1 and 1B1 mRNA. In the HepG2 human liver cancer cell line, sulindac caused a sustained, dose-dependent increase in CYP enzyme activity. Sulindac treatment resulted in a profound, dose-dependent increase in CYP 1A1 mRNA and a modest increase in 1A2 mRNA. The increase in CYP 1A1 mRNA induced by sulindac was, like enzyme activity, sustained for several days after the initial treatment. Sulindac induced the transcription of the CYP1A1 gene, as measured by the level of heterogeneous nuclear 1A1 RNA and by actinomycin D chase experiment. Since the transcription of CYP1A1 is under the control of the aryl hydrocarbon receptor (AhR), we examined the ability of sulindac to activate the receptor. Sulindac bound to the AhR, as measured by ligand-binding assay, and induced the binding of the AhR with the xenobiotic-responsive element present in the promoter region of the CYP1A1 gene. These results are the first demonstration that NSAIDs modulate carcinogen metabolic enzymes and provide a novel mechanism to explain the established chemopreventive activity of sulindac. JF - Carcinogenesis AU - Ciolino, Henry P AU - MacDonald, Christopher J AU - Memon, Omar S AU - Bass, Sara E AU - Yeh, Grace Chao AD - Cellular Defense and Carcinogenesis Section, Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health Frederick, MD, USA. hcp@mail.utexas.edu Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1586 EP - 1592 VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Antineoplastic Agents KW - 0 KW - Protein Synthesis Inhibitors KW - RNA, Messenger KW - Receptors, Aryl Hydrocarbon KW - Xenobiotics KW - Sulindac KW - 184SNS8VUH KW - Dactinomycin KW - 1CC1JFE158 KW - Cytochrome P-450 CYP1A1 KW - EC 1.14.14.1 KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Animals KW - Liver -- enzymology KW - Dose-Response Relationship, Drug KW - Humans KW - Liver Neoplasms -- enzymology KW - Xenobiotics -- pharmacology KW - RNA, Messenger -- genetics KW - Rats KW - Dactinomycin -- pharmacology KW - Rats, Sprague-Dawley KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Protein Synthesis Inhibitors -- pharmacology KW - Liver -- drug effects KW - Carcinoma, Hepatocellular -- genetics KW - In Vitro Techniques KW - Promoter Regions, Genetic -- genetics KW - Carcinoma, Hepatocellular -- enzymology KW - Breast Neoplasms -- enzymology KW - Male KW - Liver Neoplasms -- genetics KW - Cytochrome P-450 CYP1A1 -- genetics KW - Transcription, Genetic -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Sulindac -- pharmacology KW - Cytochrome P-450 CYP1A1 -- metabolism KW - Receptors, Aryl Hydrocarbon -- metabolism KW - Antineoplastic Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68713551?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Sulindac+regulates+the+aryl+hydrocarbon+receptor-mediated+expression+of+Phase+1+metabolic+enzymes+in+vivo+and+in+vitro.&rft.au=Ciolino%2C+Henry+P%3BMacDonald%2C+Christopher+J%3BMemon%2C+Omar+S%3BBass%2C+Sara+E%3BYeh%2C+Grace+Chao&rft.aulast=Ciolino&rft.aufirst=Henry&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1586&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Clove (Syzygium aromaticum L.), a potential chemopreventive agent for lung cancer. AN - 68712278; 16501250 AB - Spices and flavoring plants part rich in supposedly health-promoting phytochemicals are currently receiving much attention as a possible source of cancer chemopreventive compounds. Clove, the sun-dried unopened flower bud from the plant Syzygium aromaticum L. is a commonly used spice and food flavor. In the present work we assess the chemopreventive potential of aqueous infusion of clove during benzo[a]pyrene (BP)-induced lung carcinogenesis in strain A mice. Incidence of hyperplasia, dysplasia and carcinoma in situ evident in the carcinogen control group on the 8th, 17th and 26th weeks, respectively, were effectively reduced after treatment with clove infusion. Significant reduction in the number of proliferating cells and an increased number of apoptotic cells was also noted in these BP-induced lung lesions following clove treatment. Western blotting analysis revealed that clove infusion upregulates the expression of pro-apoptotic proteins p53 and Bax, and downregulates the expression of anti-apoptotic protein Bcl-2 in the precancerous stages. Expression of caspase 3 and its activation by clove infusion were evident from a very early stage of carcinogenesis (eighth week). Clove infusion was also found to downregulate the expression of some growth-promoting proteins, viz, COX-2, cMyc, Hras. The observations signify the chemopreventive potential of clove in view of its apoptogenic and anti-proliferative properties. JF - Carcinogenesis AU - Banerjee, Sarmistha AU - Panda, Chinmay Kr AU - Das, Sukta AD - Department of Cancer Chemoprevention, Chittarajan National Cancer Institute, 37, S.P. Mukherjee Road, Kolkata 700026, India. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1645 EP - 1654 VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Plant Extracts KW - 0 KW - Proto-Oncogene Proteins c-bcl-2 KW - Tumor Suppressor Protein p53 KW - bcl-2-Associated X Protein KW - Benzo(a)pyrene KW - 3417WMA06D KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Animals KW - Mice KW - Tumor Suppressor Protein p53 -- metabolism KW - bcl-2-Associated X Protein -- metabolism KW - Animals, Newborn KW - Plant Extracts -- pharmacology KW - Genes, ras -- physiology KW - Proto-Oncogene Proteins c-bcl-2 -- metabolism KW - Apoptosis -- drug effects KW - Benzo(a)pyrene -- toxicity KW - Cyclooxygenase 2 -- metabolism KW - Hyperplasia -- prevention & control KW - Female KW - Hyperplasia -- drug therapy KW - Lung Neoplasms -- prevention & control KW - Lung Neoplasms -- drug therapy KW - Carcinoma in Situ -- drug therapy KW - Chemoprevention KW - Carcinoma in Situ -- prevention & control KW - Syzygium -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68712278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Clove+%28Syzygium+aromaticum+L.%29%2C+a+potential+chemopreventive+agent+for+lung+cancer.&rft.au=Banerjee%2C+Sarmistha%3BPanda%2C+Chinmay+Kr%3BDas%2C+Sukta&rft.aulast=Banerjee&rft.aufirst=Sarmistha&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Colposcopy at a crossroads. AN - 68711975; 16677597 AB - New cervical cancer prevention strategies are arising from rapidly improving insight into human papillomavirus (HPV) natural history and cervical carcinogenesis, challenging the conventional roles of cytology and colposcopically directed biopsy as the reference standards of screening and diagnosis, respectively. HPV testing has high sensitivity but mediocre specificity and positive predictive value, making the role of colposcopy for the accurate identification of patients requiring treatment even more important. We believe that deficiencies of the colposcopically guided biopsy must be addressed, in particular, the inaccuracy of biopsy placement leading to low sensitivity for detection of CIN3. This opinion outlines our concerns and summarizes new data, suggesting possible steps that may lead to improvement in colposcopic accuracy. JF - American journal of obstetrics and gynecology AU - Jeronimo, Jose AU - Schiffman, Mark AD - Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Resources, Bethesda, MD, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 349 EP - 353 VL - 195 IS - 2 KW - Abridged Index Medicus KW - Index Medicus KW - Sensitivity and Specificity KW - Papillomavirus Infections -- diagnosis KW - Papillomaviridae -- isolation & purification KW - Humans KW - Female KW - Uterine Cervical Neoplasms -- prevention & control KW - Colposcopy -- methods KW - Uterine Cervical Neoplasms -- diagnosis KW - Carcinoma in Situ -- diagnosis KW - Carcinoma in Situ -- virology KW - Carcinoma in Situ -- prevention & control KW - Uterine Cervical Neoplasms -- virology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68711975?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+obstetrics+and+gynecology&rft.atitle=Colposcopy+at+a+crossroads.&rft.au=Jeronimo%2C+Jose%3BSchiffman%2C+Mark&rft.aulast=Jeronimo&rft.aufirst=Jose&rft.date=2006-08-01&rft.volume=195&rft.issue=2&rft.spage=349&rft.isbn=&rft.btitle=&rft.title=American+journal+of+obstetrics+and+gynecology&rft.issn=1097-6868&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-20 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994. AN - 68706334; 16882527 AB - Volatile organic compounds (VOCs) are present in much higher concentrations indoors, where people spend most of their time, than outdoors and may have adverse health effects. VOCs have been associated with respiratory symptoms, but few studies address objective respiratory end points such as pulmonary function. Blood levels of VOCs may be more indicative of personal exposures than are air concentrations; no studies have addressed their relationship with respiratory outcomes. We examined whether concentrations of 11 VOCs that were commonly identified in blood from a sample of the U.S. population were associated with pulmonary function. We used data from 953 adult participants (20-59 years of age) in the Third National Health and Nutrition Examination Survey (1988-1994) who had VOC blood measures as well as pulmonary function measures. Linear regression models were used to evaluate the relationship between 11 VOCs and measures of pulmonary function. After adjustment for smoking, only 1,4-dichlorobenzene (1,4-DCB) was associated with reduced pulmonary function. Participants in the highest decile of 1,4-DCB concentration had decrements of -153 mL [95% confidence interval (CI) , -297 to -8] in forced expiratory volume in 1 sec and -346 mL/sec (95% CI, -667 to -24) in maximum mid-expiratory flow rate, compared with participants in the lowest decile. Exposure to 1,4-DCB, a VOC related to the use of air fresheners, toilet bowl deodorants, and mothballs, at levels found in the U.S. general population, may result in reduced pulmonary function. This common exposure may have long-term adverse effects on respiratory health. JF - Environmental health perspectives AU - Elliott, Leslie AU - Longnecker, Matthew P AU - Kissling, Grace E AU - London, Stephanie J AD - National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709-2233, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1210 EP - 1214 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Organic Chemicals KW - 0 KW - Index Medicus KW - Respiratory Function Tests KW - Regression Analysis KW - Humans KW - Adult KW - Middle Aged KW - Forced Expiratory Volume -- physiology KW - Environmental Exposure -- adverse effects KW - United States -- epidemiology KW - Smoking -- epidemiology KW - Male KW - Female KW - Health Surveys KW - Organic Chemicals -- analysis KW - Nutrition Surveys KW - Lung -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68706334?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+health+perspectives&rft.atitle=Volatile+organic+compounds+and+pulmonary+function+in+the+Third+National+Health+and+Nutrition+Examination+Survey%2C+1988-1994.&rft.au=Elliott%2C+Leslie%3BLongnecker%2C+Matthew+P%3BKissling%2C+Grace+E%3BLondon%2C+Stephanie+J&rft.aulast=Elliott&rft.aufirst=Leslie&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1210&rft.isbn=&rft.btitle=&rft.title=Environmental+health+perspectives&rft.issn=00916765&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-30 N1 - Date created - 2006-08-02 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Occup Environ Med. 1995 Jun;52(6):388-95 [7627316] Environ Health Perspect. 2006 Mar;114(3):453-9 [16507471] J Anal Toxicol. 1995 Sep;19(5):323-9 [7500620] BMJ. 1996 Sep 21;313(7059):711-5; discussion 715-6 [8819439] Int Arch Occup Environ Health. 1997;69(2):115-24 [9001918] Arch Environ Health. 1997 Jan-Feb;52(1):26-33 [9039854] Chem Biol Interact. 1997 Jan 24;103(1):17-33 [9051121] AMA Arch Ind Health. 1956 Aug;14(2):138-47 [13353999] Arch Environ Health. 2003 Oct;58(10):633-41 [15562635] Clin Exp Allergy. 1997 Nov;27(11):1270-8 [9420130] Int J Occup Environ Health. 2000 Jan-Mar;6(1):1-8 [10637531] Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):665-73 [10673213] Int J Hyg Environ Health. 2000 Mar;203(1):23-8 [10956586] Arch Environ Health. 2001 Mar-Apr;56(2):157-66 [11339680] Environ Health Perspect. 2002 Aug;110(8):765-70 [12153756] Am J Epidemiol. 2002 Oct 15;156(8):738-46 [12370162] Environ Health Perspect. 2003 Apr;111(4):647-56 [12676630] Thorax. 2003 Nov;58(11):955-60 [14586048] Thorax. 2004 Sep;59(9):746-51 [15333849] Environ Res. 1987 Aug;43(2):290-307 [3608934] Am J Public Health. 1989 Mar;79(3):340-9 [2916724] Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):751-4 [2008987] Arch Environ Health. 1992 Jan-Feb;47(1):39-44 [1540001] Anal Chem. 1992 May 1;64(9):1021-9 [1590585] Environ Health Perspect. 1991 Nov;95:7-13 [1821381] J Expo Anal Environ Epidemiol. 1991 Apr;1(2):157-92 [1824315] Clin Chem. 1994 Jul;40(7 Pt 2):1376-84 [8013122] Clin Chem. 1994 Jul;40(7 Pt 2):1401-4 [8013127] Environ Health Perspect. 2005 Mar;113(3):342-9 [15743726] Environ Health Perspect. 2005 Nov;113(11):1542-8 [16263509] Arch Environ Health. 1995 Jul-Aug;50(4):277-80 [7677426] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Activator protein-1 activity regulates epithelial tumor cell identity. AN - 68703794; 16885357 AB - To examine the consequences of inhibiting activator protein-1 (AP-1) transcription factors in skin, transgenic mice were generated, which use the tetracycline system to conditionally express A-FOS, a dominant negative that inhibits AP-1 DNA binding. Older mice develop mild alopecia and hyperplasia of sebaceous glands, particularly around the eyes. When A-FOS was expressed during chemical-induced skin carcinogenesis, mice do not develop characteristic benign and malignant squamous lesions but instead develop benign sebaceous adenomas containing a signature mutation in the H-ras proto-oncogene. Inhibiting AP-1 activity after tumor formation caused squamous tumors to transdifferentiate into sebaceous tumors. Furthermore, reactivating AP-1 in sebaceous tumors results in a reciprocal transdifferentiation into squamous tumors. In both cases of transdifferentiation, individual cells express molecular markers for both cell types, indicating individual tumor cells have the capacity to express multiple lineages. Molecular characterization of cultured keratinocytes and tumor material indicates that AP-1 regulates the balance between the wnt/beta-catenin and hedgehog signaling pathways that determine squamous and sebaceous lineages, respectively. Chromatin immunoprecipitation analysis indicates that c-Jun binds several wnt promoters, which are misregulated by A-FOS expression, suggesting that members of the wnt pathway can be a primary targets of AP-1 transcriptional regulation. Thus, AP-1 activity regulates tumor cell lineage and is essential to maintain the squamous tumor cell identity. JF - Cancer research AU - Gerdes, Michael J AU - Myakishev, Maxim AU - Frost, Nicholas A AU - Rishi, Vikas AU - Moitra, Jaideep AU - Acharya, Asha AU - Levy, Michelle R AU - Park, Sang-won AU - Glick, Adam AU - Yuspa, Stuart H AU - Vinson, Charles AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Center for Cancer Research, Bethesda, MD 20892, USA. Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 7578 EP - 7588 VL - 66 IS - 15 SN - 0008-5472, 0008-5472 KW - DNA, Neoplasm KW - 0 KW - Proto-Oncogene Proteins c-fos KW - Proto-Oncogene Proteins c-jun KW - Transcription Factor AP-1 KW - Wnt Proteins KW - Index Medicus KW - Animals KW - Sebaceous Glands -- pathology KW - Proto-Oncogene Proteins c-jun -- metabolism KW - Mice KW - Precancerous Conditions -- metabolism KW - Mice, Transgenic KW - Protein Binding KW - Transcriptional Activation KW - Precancerous Conditions -- pathology KW - Wnt Proteins -- genetics KW - Hyperplasia KW - Precancerous Conditions -- genetics KW - Promoter Regions, Genetic KW - Proto-Oncogene Proteins c-fos -- genetics KW - Keratinocytes -- metabolism KW - DNA, Neoplasm -- metabolism KW - Proto-Oncogene Proteins c-fos -- biosynthesis KW - Transcription Factor AP-1 -- antagonists & inhibitors KW - Transcription Factor AP-1 -- metabolism KW - Carcinoma, Squamous Cell -- pathology KW - Adenocarcinoma, Sebaceous -- metabolism KW - Adenocarcinoma, Sebaceous -- pathology KW - Skin Neoplasms -- pathology KW - Carcinoma, Squamous Cell -- metabolism KW - Transcription Factor AP-1 -- genetics KW - Skin Neoplasms -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68703794?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Activator+protein-1+activity+regulates+epithelial+tumor+cell+identity.&rft.au=Gerdes%2C+Michael+J%3BMyakishev%2C+Maxim%3BFrost%2C+Nicholas+A%3BRishi%2C+Vikas%3BMoitra%2C+Jaideep%3BAcharya%2C+Asha%3BLevy%2C+Michelle+R%3BPark%2C+Sang-won%3BGlick%2C+Adam%3BYuspa%2C+Stuart+H%3BVinson%2C+Charles&rft.aulast=Gerdes&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=66&rft.issue=15&rft.spage=7578&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-08-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Putting the fun into functional toxicogenomics. AN - 68700253; 16883652 JF - Toxicological sciences : an official journal of the Society of Toxicology AU - Cunningham, Michael L AD - Laboratory of Pharmacology and Chemistry, National Institute of Environmental Sciences, Research Triangle Park, North Carolina 27709, USA. cunning1@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 347 EP - 348 VL - 92 IS - 2 SN - 1096-6080, 1096-6080 KW - Index Medicus KW - Gene Expression Profiling KW - Oligonucleotide Array Sequence Analysis KW - Risk Assessment KW - Toxicogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68700253?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.atitle=Putting+the+fun+into+functional+toxicogenomics.&rft.au=Cunningham%2C+Michael+L&rft.aulast=Cunningham&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=92&rft.issue=2&rft.spage=347&rft.isbn=&rft.btitle=&rft.title=Toxicological+sciences+%3A+an+official+journal+of+the+Society+of+Toxicology&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-08-01 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Toxicol Sci. 2006 Aug;92(2):560-77 [16601082] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Antidepressant efficacy and hormonal effects of Sudarshana Kriya Yoga (SKY) in alcohol dependent individuals. AN - 68688401; 16740317 AB - Sudarshana Kriya Yoga (SKY) has demonstrable antidepressant effects. SKY was tested for this effect in inpatients of alcohol dependence. Following a week of detoxification management consenting subjects (n=60) were equally randomized to receive SKY therapy or not (controls) for a two-week study. SKY therapy included alternate day practice of specified breathing exercise under supervision of a trained therapist. Subjects completed the Beck Depression Inventory (BDI) before and after the two weeks of this intervention. Morning plasma cortisol, ACTH and prolactin too were measured before and at the end of two weeks. In both groups reductions in BDI scores occurred but significantly more so in SKY group. Likewise, in both groups plasma cortisol as well as ACTH fell after two weeks but significantly more so in SKY group. Reduction in BDI scores correlated with that in cortisol in SKY but not in control group. Antidepressant effects of SKY were demonstrated in early abstinence that also had substantial spontaneous improvement. It is not known if this effect contributes to sustained abstinence. Results extend the antidepressant effects of SKY in alcohol dependence subjects. Reduction in stress-hormone levels (cortisol and ACTH) along with BDI reductions possibly support a biological mechanism of SKY in producing beneficial effects. JF - Journal of affective disorders AU - Vedamurthachar, A AU - Janakiramaiah, Nimmagadda AU - Hegde, Jayaram M AU - Shetty, Taranath K AU - Subbakrishna, D K AU - Sureshbabu, S V AU - Gangadhar, B N AD - National Institute of Mental Health and Neurosciences, Bangalore, India. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 249 EP - 253 VL - 94 IS - 1-3 SN - 0165-0327, 0165-0327 KW - Ethanol KW - 3K9958V90M KW - Adrenocorticotropic Hormone KW - 9002-60-2 KW - Prolactin KW - 9002-62-4 KW - Hydrocortisone KW - WI4X0X7BPJ KW - Index Medicus KW - Breathing Exercises KW - Humans KW - Adult KW - Personality Inventory KW - Middle Aged KW - Statistics as Topic KW - Adolescent KW - Male KW - Female KW - Alcoholism -- rehabilitation KW - Prolactin -- blood KW - Substance Withdrawal Syndrome -- diagnosis KW - Yoga -- psychology KW - Depressive Disorder -- blood KW - Hydrocortisone -- blood KW - Ethanol -- adverse effects KW - Substance Withdrawal Syndrome -- rehabilitation KW - Depressive Disorder -- diagnosis KW - Substance Withdrawal Syndrome -- blood KW - Adrenocorticotropic Hormone -- blood KW - Alcoholism -- blood KW - Depressive Disorder -- rehabilitation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68688401?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+affective+disorders&rft.atitle=Antidepressant+efficacy+and+hormonal+effects+of+Sudarshana+Kriya+Yoga+%28SKY%29+in+alcohol+dependent+individuals.&rft.au=Vedamurthachar%2C+A%3BJanakiramaiah%2C+Nimmagadda%3BHegde%2C+Jayaram+M%3BShetty%2C+Taranath+K%3BSubbakrishna%2C+D+K%3BSureshbabu%2C+S+V%3BGangadhar%2C+B+N&rft.aulast=Vedamurthachar&rft.aufirst=A&rft.date=2006-08-01&rft.volume=94&rft.issue=1-3&rft.spage=249&rft.isbn=&rft.btitle=&rft.title=Journal+of+affective+disorders&rft.issn=01650327&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-09 N1 - Date created - 2006-07-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cleavage map and proteolytic processing of the murine norovirus nonstructural polyprotein in infected cells. AN - 68685846; 16873239 AB - Murine norovirus (MNV) is presently the only member of the genus Norovirus in the Caliciviridae that can be propagated in cell culture. The goal of this study was to elucidate the proteolytic processing strategy of MNV during an authentic replication cycle in cells. A proteolytic cleavage map of the ORF1 polyprotein was generated, and the virus-encoded 3C-like (3CL) proteinase (Pro) mediated cleavage at five dipeptide cleavage sites, 341E/G342, Q705/N706, 870E/G871, 994E/A995, and 1177Q/G1178, that defined the borders of six proteins with the gene order p38.3 (Nterm)-p39.6 (NTPase)-p18.6-p14.3 (VPg)-p19.2 (Pro)-p57.5 (Pol). Bacterially expressed MNV 3CL Pro was sufficient to mediate trans cleavage of the ORF1 polyprotein containing the mutagenized Pro sequence into products identical to those observed during cotranslational processing of the authentic ORF1 polyprotein in vitro and to those observed in MNV-infected cells. Immunoprecipitation and Western blot analysis of proteins produced in virus-infected cells demonstrated efficient cleavage of the proteinase-polymerase precursor. Evidence for additional processing of the Nterm protein in MNV-infected cells by caspase 3 was obtained, and Nterm sequences 118DRPD121 and 128DAMD131 were mapped as caspase 3 cleavage sites by site-directed mutagenesis. The availability of the MNV nonstructural polyprotein cleavage map in concert with a permissive cell culture system should facilitate studies of norovirus replication. JF - Journal of virology AU - Sosnovtsev, Stanislav V AU - Belliot, Gaël AU - Chang, Kyeong-Ok AU - Prikhodko, Victor G AU - Thackray, Larissa B AU - Wobus, Christiane E AU - Karst, Stephanie M AU - Virgin, Herbert W AU - Green, Kim Y AD - Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-8007, USA. ss216m@nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 7816 EP - 7831 VL - 80 IS - 16 SN - 0022-538X, 0022-538X KW - Polyproteins KW - 0 KW - Viral Nonstructural Proteins KW - Casp3 protein, mouse KW - EC 3.4.22.- KW - Caspase 3 KW - Caspases KW - Cysteine Endopeptidases KW - Index Medicus KW - Virus Replication KW - Animals KW - Cells, Cultured KW - Molecular Sequence Data KW - Immunoprecipitation KW - Mice KW - Amino Acid Sequence KW - Caspases -- metabolism KW - Mutagenesis KW - Caliciviridae Infections -- virology KW - Viral Nonstructural Proteins -- genetics KW - Cysteine Endopeptidases -- metabolism KW - Polyproteins -- genetics KW - Norovirus -- metabolism KW - Polyproteins -- metabolism KW - Viral Nonstructural Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68685846?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Cleavage+map+and+proteolytic+processing+of+the+murine+norovirus+nonstructural+polyprotein+in+infected+cells.&rft.au=Sosnovtsev%2C+Stanislav+V%3BBelliot%2C+Ga%C3%ABl%3BChang%2C+Kyeong-Ok%3BPrikhodko%2C+Victor+G%3BThackray%2C+Larissa+B%3BWobus%2C+Christiane+E%3BKarst%2C+Stephanie+M%3BVirgin%2C+Herbert+W%3BGreen%2C+Kim+Y&rft.aulast=Sosnovtsev&rft.aufirst=Stanislav&rft.date=2006-08-01&rft.volume=80&rft.issue=16&rft.spage=7816&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-28 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: J Virol. 1998 Apr;72(4):3051-9 [9525628] Protein Sci. 1996 Feb;5(2):363-71 [8745415] Arch Virol. 1998;143(12):2421-30 [9930197] J Gen Virol. 1999 Feb;80 ( Pt 2):291-6 [10073687] J Virol. 1999 Dec;73(12):10531-5 [10559373] J Infect Dis. 2000 May;181 Suppl 2:S336-48 [10804147] J Virol. 2000 Jul;74(14):6581-91 [10864672] Virology. 2000 Oct 25;276(2):349-63 [11040126] J Virol. 1996 Nov;70(11):7974-83 [8892921] J Gen Virol. 1997 May;78 ( Pt 5):1033-40 [9152420] J Virol. 1999 Aug;73(8):6626-33 [10400760] Emerg Infect Dis. 1999 Sep-Oct;5(5):607-25 [10511517] PLoS Biol. 2004 Dec;2(12):e432 [15562321] J Virol. 2005 Feb;79(4):2393-403 [15681440] Emerg Infect Dis. 2005 May;11(5):735-7 [15898170] J Virol. 2005 Jun;79(12):7283-90 [15919882] Virology. 2005 Jul 5;337(2):373-83 [15901487] EMBO Rep. 2005 Oct;6(10):968-72 [16142217] J Virol. 2005 Nov;79(21):13685-93 [16227288] J Gen Virol. 2006 Feb;87(Pt 2):363-8 [16432023] Virology. 2006 Mar 15;346(2):312-23 [16343580] Virology. 2000 Nov 10;277(1):193-203 [11062050] J Virol. 2001 Feb;75(3):1211-9 [11152494] J Biol Chem. 2001 Jul 27;276(30):27787-92 [11369764] J Virol. 2002 Jun;76(12):5949-58 [12021327] J Virol. 2002 Jul;76(14):7060-72 [12072506] J Virol. 2002 Sep;76(17):8582-95 [12163578] Virus Res. 2002 Oct;89(1):29-39 [12367748] Science. 2003 Mar 7;299(5612):1575-8 [12624267] J Gen Virol. 2003 May;84(Pt 5):1237-44 [12692289] Virology. 2003 Apr 10;308(2):216-24 [12706072] J Virol. 2003 Jun;77(12):7150-5 [12768037] EMBO J. 2003 Jun 2;22(11):2852-9 [12773399] J Gen Virol. 2003 Oct;84(Pt 10):2837-45 [13679618] J Virol. 2003 Oct;77(20):10957-74 [14512545] J Virol. 2003 Nov;77(21):11790-7 [14557663] Lancet. 2004 Feb 28;363(9410):682-8 [15001325] J Virol. 2004 Apr;78(8):3889-96 [15047805] J Virol. 2004 May;78(9):4827-37 [15078964] J Clin Virol. 2004 Jul;30(3):243-7 [15135743] J Clin Microbiol. 2004 Jul;42(7):2988-95 [15243049] J Virol. 2004 Aug;78(15):8172-82 [15254188] J Gen Virol. 1980 Mar;47(1):215-20 [7365464] Science. 1993 Jan 22;259(5094):516-9 [8380940] Virology. 1993 Jul;195(1):51-61 [8391187] J Mol Biol. 1993 Jul 20;232(2):584-99 [8345525] J Virol. 1994 Oct;68(10):6794-8 [8084017] J Virol. 1995 Nov;69(11):7159-68 [7474137] J Virol. 1996 Apr;70(4):2605-10 [8642693] J Virol. 1998 May;72(5):4492-7 [9557747] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ligand-independent homo- and heterodimerization of human prolactin receptor variants: inhibitory action of the short forms by heterodimerization. AN - 68677574; 16556730 AB - Prolactin (PRL) acts through the long form (LF) of the human PRL receptor (hPRLR) to cause differentiation of mammary epithelial cells through activation of the Janus kinase-2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) pathway and subsequent transcriptional events. To determine whether the inhibitory action of hPRLR short forms (SFs; S1a and S1b) on PRL-induced signal transduction through the LF results from heterodimerization, we studied complex formation among variant forms of the hPRLR. 3'-Tagged fusion constructs, with activities comparable to the wild-type species, were used to investigate homodimer and heterodimer formation. The LF and both SFs of the hPRLR formed homodimers under nonreducing conditions, independently of PRL, but formed only monomers under reducing conditions. Coimmunoprecipitation of the cotransfected LF with the SFs (S1a or S1b) in transfected cells showed ligand-independent heterodimerization of individual SFs with the LF. Bioluminescence resonance energy transfer analysis demonstrated homo- and heterodimeric associations of hPRLR variants in human embryonic kidney 293 cells. Biotin-avidin immunoprecipitation analysis revealed that hPRLR forms are cell surface receptors and that SFs do not influence the steady state or half-life of the LF. Significant homo- and heterodimerization of biotinylated membrane hPRLR forms was observed. These findings indicate that homo- and heterodimers of hPRLR are constitutively present, and that the bivalent hormone acts on the preformed LF homodimer to induce the active signal transduction configuration. Although SF homodimers and their heterodimers with LF mediate JAK2 activation, the SF heterodimer partner lacks cytoplasmic sequences essential for activation of the JAK2/signal transducer and activator of transcription 5 pathway. This prevents the heterodimeric LF from mediating activation of PRL-induced genes. JF - Molecular endocrinology (Baltimore, Md.) AU - Qazi, Aamer M AU - Tsai-Morris, Chon-Hwa AU - Dufau, Maria L AD - Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1912 EP - 1923 VL - 20 IS - 8 SN - 0888-8809, 0888-8809 KW - Antigens, Surface KW - 0 KW - GFP10 Protein KW - Ligands KW - Luminescent Proteins KW - Oligopeptides KW - Peptides KW - Protein Isoforms KW - Proto-Oncogene Proteins KW - Receptors, Prolactin KW - Recombinant Proteins KW - Green Fluorescent Proteins KW - 147336-22-9 KW - Prolactin KW - 9002-62-4 KW - FLAG peptide KW - 98849-88-8 KW - Protein-Tyrosine Kinases KW - EC 2.7.10.1 KW - JAK2 protein, human KW - EC 2.7.10.2 KW - Janus Kinase 2 KW - Cysteine KW - K848JZ4886 KW - Index Medicus KW - Cysteine -- metabolism KW - Humans KW - Fluorescence Resonance Energy Transfer KW - Proto-Oncogene Proteins -- metabolism KW - Peptides -- metabolism KW - Luminescent Proteins -- metabolism KW - Protein-Tyrosine Kinases -- metabolism KW - Mutagenesis, Site-Directed KW - Transfection KW - Recombinant Proteins -- metabolism KW - Cells, Cultured KW - Antigens, Surface -- metabolism KW - Green Fluorescent Proteins -- metabolism KW - Receptors, Prolactin -- metabolism KW - Protein Isoforms -- metabolism KW - Dimerization KW - Prolactin -- pharmacology KW - Receptors, Prolactin -- antagonists & inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68677574?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.atitle=Ligand-independent+homo-+and+heterodimerization+of+human+prolactin+receptor+variants%3A+inhibitory+action+of+the+short+forms+by+heterodimerization.&rft.au=Qazi%2C+Aamer+M%3BTsai-Morris%2C+Chon-Hwa%3BDufau%2C+Maria+L&rft.aulast=Qazi&rft.aufirst=Aamer&rft.date=2006-08-01&rft.volume=20&rft.issue=8&rft.spage=1912&rft.isbn=&rft.btitle=&rft.title=Molecular+endocrinology+%28Baltimore%2C+Md.%29&rft.issn=08888809&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Effect of mutation on the dissociation and recombination dynamics of CO in transcriptional regulator CooA: a picosecond infrared transient absorption study. AN - 68676521; 16866371 AB - The CO ligation process in a mutant (H77G) of CooA, the CO-sensing transcriptional regulator in Rhodospirillum rubrum, is studied with femtosecond time-resolved transient absorption spectroscopy in the mid-infrared region. Following photolyzing excitation, a transient bleach in the vibrational region of bound CO due to the CO photodissociation is detected. In contrast to the spectra of the wild-type (WT) CooA, the transient bleach spectra of H77G CooA show a bimodal shape with peaks shifting to the lower frequency during spectral evolution. The CO recombination dynamics show single-exponential behavior, and the CO escaping yield is higher than that of the WT CooA. A reorientation process of CO relative to the heme plane during recombination is revealed by anisotropy measurements. These phenomena indicate changes in the protein response to the CO ligation and suggest an alteration to the CO environment caused by the mutation. On the basis of these results, the role of His77 in the CO-dependent activation of CooA and a possible activation mechanism involving collaborative movement of the heme and the amino residues at both sides of the heme plane are discussed. JF - Biochemistry AU - Zhang, Tieqiao AU - Rubtsov, Igor V AU - Nakajima, Hiroshi AU - Aono, Shigetoshi AU - Yoshihara, Keitaro AD - School of Materials Science, Japan Advanced Institute of Science and Technology, Tatsunokuchi, Ishikawa 923-1292, Japan. zhangti@mail.nih.gov Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 9246 EP - 9253 VL - 45 IS - 30 SN - 0006-2960, 0006-2960 KW - Bacterial Proteins KW - 0 KW - CooA protein, Rhodospirillum rubrum KW - Hemeproteins KW - Trans-Activators KW - Heme KW - 42VZT0U6YR KW - Histidine KW - 4QD397987E KW - Carbon Monoxide KW - 7U1EE4V452 KW - Glycine KW - TE7660XO1C KW - Index Medicus KW - Rhodospirillum rubrum -- genetics KW - Glycine -- genetics KW - Models, Molecular KW - Histidine -- genetics KW - Heme -- chemistry KW - Models, Chemical KW - Spectroscopy, Near-Infrared -- methods KW - Rhodospirillum rubrum -- chemistry KW - Mutagenesis, Site-Directed KW - Trans-Activators -- metabolism KW - Bacterial Proteins -- genetics KW - Hemeproteins -- metabolism KW - Bacterial Proteins -- chemistry KW - Trans-Activators -- genetics KW - Recombination, Genetic KW - Bacterial Proteins -- metabolism KW - Trans-Activators -- chemistry KW - Regulatory Elements, Transcriptional -- physiology KW - Hemeproteins -- genetics KW - Carbon Monoxide -- metabolism KW - Hemeproteins -- chemistry KW - Carbon Monoxide -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68676521?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=Effect+of+mutation+on+the+dissociation+and+recombination+dynamics+of+CO+in+transcriptional+regulator+CooA%3A+a+picosecond+infrared+transient+absorption+study.&rft.au=Zhang%2C+Tieqiao%3BRubtsov%2C+Igor+V%3BNakajima%2C+Hiroshi%3BAono%2C+Shigetoshi%3BYoshihara%2C+Keitaro&rft.aulast=Zhang&rft.aufirst=Tieqiao&rft.date=2006-08-01&rft.volume=45&rft.issue=30&rft.spage=9246&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Trends in cancer risk among people with AIDS in the United States 1980-2002. AN - 68671987; 16868446 AB - People with AIDS have heightened cancer risk from immunosuppression. HAART has been available since 1996 and has reduced AIDS-related mortality, but there are few large-scale studies on cancer trends. AIDS and cancer registries in 11 US regions (1980-2002) were used to identify cancers in 375 933 people with AIDS. Cancer risk relative to the general population was measured using the standardized incidence ratio (SIR), focusing on the 2 years after AIDS onset for those with AIDS in 1990-1995 and 1996-2002 (HAART era). Time trends were assessed with Poisson regression. Between 1990-1995 and 1996-2002, risk declined for the two major AIDS-defining cancers: Kaposi sarcoma [(KS) n = 5131; SIR, 22 100 and 3640, respectively; P < 0.0001] and non-Hodgkin lymphoma [(NHL) n = 3412; SIR, 53.2 and 22.6, respectively; P < 0.0001]. Declines began in the 1980s, but risk fell sharply in 1996 and was stable thereafter. Risk of cervical cancer did not change (n = 64; SIR, 4.2 and 5.3, respectively; P = 0.33). Among non-AIDS malignancies, lung cancer was most common, but risk declined between 1990-1995 and 1996-2002 (n = 344; SIR, 3.3 and 2.6, respectively; P = 0.02). Risk of Hodgkin lymphoma increased substantially over the 1990-2002 period (n = 149; SIR, 8.1 and 13.6, respectively; P = 0.003). Dramatic declines in KS and NHL were temporally related to improving therapies, especially introduction of HAART, but those with AIDS remain at marked risk. Among non-AIDS-related cancers, a recent increase in Hodgkin lymphoma was observed. JF - AIDS (London, England) AU - Engels, Eric A AU - Pfeiffer, Ruth M AU - Goedert, James J AU - Virgo, Phillip AU - McNeel, Timothy S AU - Scoppa, Steven M AU - Biggar, Robert J AU - HIV/AIDS Cancer Match Study AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. engelse@exchange.nih.gov ; HIV/AIDS Cancer Match Study Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1645 EP - 1654 VL - 20 IS - 12 SN - 0269-9370, 0269-9370 KW - Index Medicus KW - AIDS/HIV KW - Lung Neoplasms -- complications KW - Uterine Cervical Neoplasms -- complications KW - Humans KW - Lung Neoplasms -- immunology KW - Hodgkin Disease -- immunology KW - Lymphoma, Non-Hodgkin -- immunology KW - Hodgkin Disease -- epidemiology KW - Antiretroviral Therapy, Highly Active -- adverse effects KW - Lymphoma, Non-Hodgkin -- epidemiology KW - Lung Neoplasms -- epidemiology KW - Adult KW - Kidney Neoplasms -- complications KW - Adolescent KW - Sarcoma, Kaposi -- immunology KW - Male KW - Lymphoma, Non-Hodgkin -- complications KW - Kidney Neoplasms -- epidemiology KW - Sarcoma, Kaposi -- epidemiology KW - Sarcoma, Kaposi -- complications KW - Hodgkin Disease -- complications KW - Age Distribution KW - Uterine Cervical Neoplasms -- epidemiology KW - Risk Factors KW - Incidence KW - Middle Aged KW - Uterine Cervical Neoplasms -- immunology KW - United States -- epidemiology KW - Sex Distribution KW - Female KW - Kidney Neoplasms -- immunology KW - Acquired Immunodeficiency Syndrome -- complications KW - Neoplasms -- complications KW - Acquired Immunodeficiency Syndrome -- epidemiology KW - Neoplasms -- epidemiology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68671987?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=AIDS+%28London%2C+England%29&rft.atitle=Trends+in+cancer+risk+among+people+with+AIDS+in+the+United+States+1980-2002.&rft.au=Engels%2C+Eric+A%3BPfeiffer%2C+Ruth+M%3BGoedert%2C+James+J%3BVirgo%2C+Phillip%3BMcNeel%2C+Timothy+S%3BScoppa%2C+Steven+M%3BBiggar%2C+Robert+J%3BHIV%2FAIDS+Cancer+Match+Study&rft.aulast=Engels&rft.aufirst=Eric&rft.date=2006-08-01&rft.volume=20&rft.issue=12&rft.spage=1645&rft.isbn=&rft.btitle=&rft.title=AIDS+%28London%2C+England%29&rft.issn=02699370&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-09 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cytoreduction combined with intraperitoneal hyperthermic perfusion chemotherapy in advanced/recurrent ovarian cancer patients: The experience of National Cancer Institute of Milan. AN - 68671468; 16621425 AB - We report the effects of cytoreductive surgery (CRS) and intraperitoneal hyperthermic perfusion (IPHP) in the treatment of advanced/recurrent epithelial ovarian cancer (EOC) on survival, morbidity and mortality. Forty EOC patients were studied. Median age was 52.5 years (range: 30-68) and median follow-up 26.1 months (range: 0.3-117.6). Most patients presented advanced disease (stage III/IV). Previous systemic chemotherapy included cisplatin-based, taxol-based or taxol/platinum containing regimens. After the CRS, 33 patients presented no macroscopic residual disease. Five-year overall survival was 15%; the mean overall and progression-free survivals were 41.4 and 23.9 months, respectively. The morbidity, toxicity and mortality rates were 5%, 15% and 0%, respectively. Our results suggest that CRS + IPHP merits further evaluation by a formal prospective trial. JF - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology AU - Raspagliesi, F AU - Kusamura, S AU - Campos Torres, J C AU - de Souza, G A AU - Ditto, A AU - Zanaboni, F AU - Younan, R AU - Baratti, D AU - Mariani, L AU - Laterza, B AU - Deraco, M AD - Department of Surgery-Gynaecology Unit, National Cancer Institute of Milan, Milan, Italy. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 671 EP - 675 VL - 32 IS - 6 SN - 0748-7983, 0748-7983 KW - Mitomycin KW - 50SG953SK6 KW - Doxorubicin KW - 80168379AG KW - Cisplatin KW - Q20Q21Q62J KW - Index Medicus KW - Survival Rate KW - Neoplasm Staging KW - Combined Modality Therapy KW - Humans KW - Adult KW - Treatment Outcome KW - Aged KW - Middle Aged KW - Doxorubicin -- administration & dosage KW - Mitomycin -- administration & dosage KW - Infusions, Parenteral KW - Female KW - Cisplatin -- administration & dosage KW - Ovarian Neoplasms -- pathology KW - Hyperthermia, Induced KW - Ovarian Neoplasms -- surgery KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Ovarian Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68671468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+surgical+oncology+%3A+the+journal+of+the+European+Society+of+Surgical+Oncology+and+the+British+Association+of+Surgical+Oncology&rft.atitle=Cytoreduction+combined+with+intraperitoneal+hyperthermic+perfusion+chemotherapy+in+advanced%2Frecurrent+ovarian+cancer+patients%3A+The+experience+of+National+Cancer+Institute+of+Milan.&rft.au=Raspagliesi%2C+F%3BKusamura%2C+S%3BCampos+Torres%2C+J+C%3Bde+Souza%2C+G+A%3BDitto%2C+A%3BZanaboni%2C+F%3BYounan%2C+R%3BBaratti%2C+D%3BMariani%2C+L%3BLaterza%2C+B%3BDeraco%2C+M&rft.aulast=Raspagliesi&rft.aufirst=F&rft.date=2006-08-01&rft.volume=32&rft.issue=6&rft.spage=671&rft.isbn=&rft.btitle=&rft.title=European+journal+of+surgical+oncology+%3A+the+journal+of+the+European+Society+of+Surgical+Oncology+and+the+British+Association+of+Surgical+Oncology&rft.issn=07487983&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-29 N1 - Date created - 2006-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Early switch with aromatase inhibitors as adjuvant hormonal therapy for postmenopausal breast cancer: pooled-analysis of 8794 patients. AN - 68663840; 16766125 AB - The magnitude of the survival benefit of aromatase inhibitors (AIs) after 2-3 years of tamoxifen as adjuvant hormonal therapy for early breast cancer is still unclear. We performed a literature-based meta-analysis, to look how much advantages adjuvant the "early switch" strategy add over standard tamoxifen for 5 years. A pooled analysis of all phase-III trials was accomplished, and event-based relative risk ratios (RR) with 95% confidence interval (CI) were derived. Significant differences in primary outcome (EFS and RFS, event- and relapse-free survival), and secondary outcomes (OS, overall survival, deaths without progression, other cancers and toxicities), were explored. Magnitude outcome measures were absolute benefits and number of patients needed to treat. Heterogeneity test was applied as well. Five trials (8794 patients) were gathered. The risk of any event is reduced with AIs of 23%, with an absolute benefit of 3.8% (RR 0.67, 95% CI 0.59, 0.76). Again, RFS (RR 0.68, 95% CI 0.59, 0.79) or both LRFS and DFRS, were significantly improved with AIs. OS was significantly prolonged with AIs, with an absolute benefit of 1.2% (RR 0.76, 95% CI 0.62, 0.93), without significant heterogeneity. Bone fractures were significantly higher in patients receiving AIs (RR 1.50, 95% CI 1.12, 2.02), and endometrial cancer in patients who continued to receive tamoxifen (RR 0.32, 95% CI 0.13, 0.77), without significant heterogeneity. The early switch strategy improves survival over standard tamoxifen for 5 years, with a different toxicity profile. The lack of significant heterogeneity in the analysis underscores the homogenous effect across all trials. JF - Cancer treatment reviews AU - Bria, Emilio AU - Ciccarese, Mariangela AU - Giannarelli, Diana AU - Cuppone, Federica AU - Nisticò, Cecilia AU - Nuzzo, Carmen AU - Natoli, Guido AU - Fabi, Alessandra AU - Terzoli, Edmondo AU - Cognetti, Francesco AU - Carlini, Paolo AD - Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Roma, Italy. emiliobria@yahoo.it Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 325 EP - 332 VL - 32 IS - 5 SN - 0305-7372, 0305-7372 KW - Antineoplastic Agents, Hormonal KW - 0 KW - Aromatase Inhibitors KW - Tamoxifen KW - 094ZI81Y45 KW - Index Medicus KW - Disease-Free Survival KW - Postmenopause KW - Clinical Trials, Phase III as Topic KW - Humans KW - Aged KW - Middle Aged KW - Female KW - Chemotherapy, Adjuvant KW - Survival Analysis KW - Breast Neoplasms -- drug therapy KW - Antineoplastic Agents, Hormonal -- administration & dosage KW - Aromatase Inhibitors -- therapeutic use KW - Tamoxifen -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68663840?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+treatment+reviews&rft.atitle=Early+switch+with+aromatase+inhibitors+as+adjuvant+hormonal+therapy+for+postmenopausal+breast+cancer%3A+pooled-analysis+of+8794+patients.&rft.au=Bria%2C+Emilio%3BCiccarese%2C+Mariangela%3BGiannarelli%2C+Diana%3BCuppone%2C+Federica%3BNistic%C3%B2%2C+Cecilia%3BNuzzo%2C+Carmen%3BNatoli%2C+Guido%3BFabi%2C+Alessandra%3BTerzoli%2C+Edmondo%3BCognetti%2C+Francesco%3BCarlini%2C+Paolo&rft.aulast=Bria&rft.aufirst=Emilio&rft.date=2006-08-01&rft.volume=32&rft.issue=5&rft.spage=325&rft.isbn=&rft.btitle=&rft.title=Cancer+treatment+reviews&rft.issn=03057372&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-11 N1 - Date created - 2006-07-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Invited commentary: on the road to improved exposure assessment using geographic information systems. AN - 68655124; 16707652 JF - American journal of epidemiology AU - Ward, Mary H AU - Wartenberg, Daniel AD - Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. wardm@exchange.nih.gov Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 208 EP - 211 VL - 164 IS - 3 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Humans KW - Risk Assessment KW - Epidemiologic Methods KW - Environmental Exposure -- analysis KW - Geographic Information Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68655124?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Invited+commentary%3A+on+the+road+to+improved+exposure+assessment+using+geographic+information+systems.&rft.au=Ward%2C+Mary+H%3BWartenberg%2C+Daniel&rft.aulast=Ward&rft.aufirst=Mary&rft.date=2006-08-01&rft.volume=164&rft.issue=3&rft.spage=208&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-14 N1 - Date created - 2006-07-20 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment On: Am J Epidemiol. 2006 Aug 1;164(3):200-7 [16754633] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chronic lithium chloride administration to rats elevates glucose metabolism in wide areas of brain, while potentiating negative effects on metabolism of dopamine D2-like receptor stimulation. AN - 68653254; 16786332 AB - The regional cerebral metabolic rate for glucose (rCMRglc) can be imaged in vivo as a marker of brain functional activity. The effects of chronic lithium administration on baseline values of rCMRglc and values in response to administration of dopamine D2-like receptor agonists have not been examined in humans or rats. Knowing these effects may elucidate and localize the therapeutic action of lithium in bipolar disorder. In unanesthetized rats, we used the 2-deoxy-D-glucose (2-DG) technique to image the effects of a 6-week control diet or LiCl diet sufficient to produce a plasma lithium concentration therapeutically relevant to bipolar disorder, on rCMRglc at baseline and in response to the dopaminergic D2-like receptor agonist, quinpirole (1 mg/kg i.v.), or to i.v. saline. Baseline rCMRglc was significantly elevated in 30 of 81 brain regions examined, in LiCl diet compared with control diet rats. Affected were visual and auditory structures, frontal cortex, amygdala, hippocampus, nucleus accumbens, caudate-putamen, interpeduncular nucleus, and substantia nigra. Acute quinpirole significantly decreased rCMRglc in four areas of the caudate-putamen in control diet rats, and in these and 19 additional brain areas in LiCl-fed rats. In unanesthetized rats, chronic lithium administration widely upregulates baseline rCMRglc and potentiates the negative effects on rCMRglc of D2-like receptor stimulation. The baseline elevation may relate to lithium's reported ability to increase auditory and visual evoked responses in humans, whereas lithium's potentiation of quinpirole's negative effects on rCMRglc may be related to its therapeutic efficacy in bipolar disorder. JF - Psychopharmacology AU - Basselin, Mireille AU - Chang, Lisa AU - Rapoport, Stanley I AD - Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, 9 Memorial Drive, Bethesda, MD 20892-0947, USA. mirvasln@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 303 EP - 311 VL - 187 IS - 3 SN - 0033-3158, 0033-3158 KW - Receptors, Dopamine D2 KW - 0 KW - Quinpirole KW - 20OP60125T KW - Lithium Chloride KW - G4962QA067 KW - Glucose KW - IY9XDZ35W2 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Inbred F344 KW - Quinpirole -- pharmacology KW - Drug Synergism KW - Male KW - Glucose -- metabolism KW - Brain -- drug effects KW - Lithium Chloride -- pharmacology KW - Brain -- metabolism KW - Receptors, Dopamine D2 -- physiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68653254?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychopharmacology&rft.atitle=Chronic+lithium+chloride+administration+to+rats+elevates+glucose+metabolism+in+wide+areas+of+brain%2C+while+potentiating+negative+effects+on+metabolism+of+dopamine+D2-like+receptor+stimulation.&rft.au=Basselin%2C+Mireille%3BChang%2C+Lisa%3BRapoport%2C+Stanley+I&rft.aulast=Basselin&rft.aufirst=Mireille&rft.date=2006-08-01&rft.volume=187&rft.issue=3&rft.spage=303&rft.isbn=&rft.btitle=&rft.title=Psychopharmacology&rft.issn=00333158&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-07 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. AN - 68652438; 16547072 AB - Peroxisome proliferator activated receptor gamma (PPARgamma) is expressed in epithelial cells, macrophage, and T and B lymphocytes. Ligand induced activation of PPARgamma was reported to attenuate colitis activity but it is not clear whether this protection is mediated by epithelial or leucocyte PPARgamma. Mice with targeted disruption of the PPARgamma gene in intestinal epithelial cells, generated using a villin-Cre transgene and floxed PPARgamma allele and designated PPARgamma(DeltaIEpC), were compared with littermate mice having only the PPARgamma floxed allele with no Cre transgene that expressed PPARgamma in the gut, designated PPARgamma(F/F). Colitis was induced by administering dextran sodium sulphate (DSS) and the two mouse lines compared for typical symptoms of disease and expression of inflammatory cytokines. PPARgamma(DeltaIEpC) mice displayed reduced expression of the PPARgamma target genes ADRP and FABP in the gut but were otherwise normal. Increased susceptibility to DSS induced colitis, as defined by body weight loss, colon length, diarrhoea, bleeding score, and altered histology, was found in PPARgamma(DeltaIEpC) mice in comparison with PPARgamma(F/F) mice. Interleukin (IL)-6, IL-1beta, and tumour necrosis factor alpha mRNA levels in colons of PPARgamma(DeltaIEpC) mice treated with DSS were higher than in similarly treated PPARgamma(F/F) mice. The PPARgamma ligand rosiglitazone decreased the severity of DSS induced colitis and suppressed cytokine production in both PPARgamma(F/F) and PPARgamma(DeltaIEpC) mice. These studies reveal that PPARgamma expressed in the colonic epithelium has an endogenous role in protection against DSS induced colitis and that rosiglitazone may act through a PPARgamma independent pathway to suppress inflammation. JF - Gut AU - Adachi, M AU - Kurotani, R AU - Morimura, K AU - Shah, Y AU - Sanford, M AU - Madison, B B AU - Gumucio, D L AU - Marin, H E AU - Peters, J M AU - Young, H A AU - Gonzalez, F J AD - Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1104 EP - 1113 VL - 55 IS - 8 SN - 0017-5749, 0017-5749 KW - Cytokines KW - 0 KW - Ligands KW - PPAR gamma KW - RNA, Messenger KW - Thiazolidinediones KW - rosiglitazone KW - 05V02F2KDG KW - Dextran Sulfate KW - 9042-14-2 KW - Abridged Index Medicus KW - Index Medicus KW - Animals KW - Disease Susceptibility KW - Mice KW - Cytokines -- metabolism KW - RNA, Messenger -- genetics KW - Mice, Transgenic KW - Colitis -- genetics KW - Colitis -- metabolism KW - Colitis -- prevention & control KW - Epithelial Cells -- metabolism KW - Epithelial Cells -- pathology KW - Polymerase Chain Reaction -- methods KW - Colitis -- chemically induced KW - Thiazolidinediones -- therapeutic use KW - Female KW - Inflammatory Bowel Diseases -- metabolism KW - Colon -- metabolism KW - Intestinal Mucosa -- pathology KW - Intestinal Mucosa -- metabolism KW - PPAR gamma -- physiology KW - Inflammatory Bowel Diseases -- chemically induced KW - Inflammatory Bowel Diseases -- prevention & control KW - PPAR gamma -- genetics KW - PPAR gamma -- agonists KW - Inflammatory Bowel Diseases -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68652438?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Gut&rft.atitle=Peroxisome+proliferator+activated+receptor+gamma+in+colonic+epithelial+cells+protects+against+experimental+inflammatory+bowel+disease.&rft.au=Adachi%2C+M%3BKurotani%2C+R%3BMorimura%2C+K%3BShah%2C+Y%3BSanford%2C+M%3BMadison%2C+B+B%3BGumucio%2C+D+L%3BMarin%2C+H+E%3BPeters%2C+J+M%3BYoung%2C+H+A%3BGonzalez%2C+F+J&rft.aulast=Adachi&rft.aufirst=M&rft.date=2006-08-01&rft.volume=55&rft.issue=8&rft.spage=1104&rft.isbn=&rft.btitle=&rft.title=Gut&rft.issn=00175749&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Mol Cell. 1999 Oct;4(4):597-609 [10549291] Cancer Res. 2005 Jun 1;65(11):4769-74 [15930296] Mol Cell. 1999 Oct;4(4):611-7 [10549292] J Biol Chem. 2000 Feb 18;275(7):4541-4 [10671476] Nat Genet. 2000 Sep;26(1):76-80 [10973253] Gastroenterology. 2001 Feb;120(2):460-9 [11159886] J Exp Med. 2001 Apr 2;193(7):827-38 [11283155] Endocrinology. 2001 Oct;142(10):4195-202 [11564675] Am J Gastroenterol. 2001 Dec;96(12):3323-8 [11774944] Transgenic Res. 2001 Dec;10(6):545-53 [11817542] Annu Rev Immunol. 2002;20:495-549 [11861611] Mol Cell Biol. 2002 Apr;22(8):2607-19 [11909955] Mol Endocrinol. 2002 Apr;16(4):707-21 [11923467] J Biol Chem. 2002 May 17;277(20):17830-5 [11884400] N Engl J Med. 2002 Aug 8;347(6):417-29 [12167685] J Biol Chem. 2002 Sep 6;277(36):33275-83 [12065599] Nat Rev Immunol. 2002 Oct;2(10):748-59 [12360213] Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13771-6 [12370429] Lancet. 2002 Nov 2;360(9343):1410-8 [12424006] Inflamm Bowel Dis. 2002 Sep;8(5):330-9 [12479648] Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9406-11 [15956187] Int J Cancer. 2005 Sep 10;116(4):495-9 [15818612] Cell Metab. 2005 Feb;1(2):85-6 [16054047] Nat Med. 2005 Aug;11(8):861-6 [16007095] Int J Cancer. 2005 Nov 20;117(4):524-30 [15929075] Cell Death Differ. 2006 Jan;13(1):53-60 [16021179] Gastroenterology. 2004 Sep;127(3):777-91 [15362034] Gastroenterology. 2003 Feb;124(2):361-7 [12557142] J Immunol Methods. 2003 Mar 1;274(1-2):177-84 [12609543] Gastroenterology. 2003 May;124(5):1265-76 [12730867] Gastroenterology. 2003 May;124(5):1315-24 [12730872] Gastroenterology. 2003 May;124(5):1538-42 [12730893] Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7 [12740443] Cancer Res. 2003 Jul 1;63(13):3560-6 [12839942] Nat Rev Immunol. 2003 Jul;3(7):521-33 [12876555] Curr Allergy Asthma Rep. 2004 Jan;4(1):83-9 [14680627] Nat Med. 2004 Apr;10(4):355-61 [15057233] Carcinogenesis. 2004 Sep;25(9):1747-55 [15073042] Gastroenterology. 1992 Jan;102(1):18-27 [1309357] Cell. 1995 Dec 1;83(5):813-9 [8521498] Biochem Biophys Res Commun. 1996 May 24;222(3):844-51 [8651933] Inflamm Res. 1996 Apr;45(4):181-91 [8741008] Nature. 1998 Jan 1;391(6662):79-82 [9422508] World J Surg. 1998 Apr;22(4):382-9 [9523521] Cell. 1998 Apr 17;93(2):229-40 [9568715] J Clin Invest. 1999 Aug;104(4):383-9 [10449430] Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):361-75 [15584886] Genes Dev. 2005 Feb 1;19(3):362-75 [15687259] Redox Rep. 2004;9(6):376-81 [15720836] Biochimie. 2005 Jan;87(1):9-13 [15733730] Inflamm Bowel Dis. 2005 Mar;11(3):231-43 [15735429] Inflamm Bowel Dis. 2005 Mar;11(3):244-52 [15735430] Am J Hypertens. 2005 Apr;18(4 Pt 1):549-56 [15831367] J Exp Med. 2005 Apr 18;201(8):1205-15 [15824083] Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1224-9 [15894676] Comment In: Gut. 2006 Aug;55(8):1067-9 [16849341] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Synergistic interactions of SQ109, a new ethylene diamine, with front-line antitubercular drugs in vitro. AN - 68652327; 16751637 AB - The purpose of this study was to determine interactions of SQ109, a new asymmetric diamine tuberculosis (TB) drug candidate, with existing antitubercular drugs in vitro and assess its potential to improve combination drug activities against Mycobacterium tuberculosis. Two-drug combinations at various concentrations below their MICs were tested for growth inhibition of M. tuberculosis using the BACTEC 460 system in vitro. Drug interactions were evaluated based on the quotient values that were derived numerically from the growth indices of cultures treated with a single antibiotic or combination treatment with two antibiotics. SQ109 at 0.5 of its MIC demonstrated strong Synergistic activity with 0.5 MIC isoniazid and as low as 0.1 MIC rifampicin in inhibition of M. tuberculosis growth. Additive effects were observed between SQ109 and streptomycin, but neither synergy nor additive effects were observed with the combination of SQ109 with ethambutol or pyrazinamide. The synergy between SQ109 and rifampicin was also demonstrated using rifampicin-resistant (RIFR) M. tuberculosis strains; SQ109 lowered the MIC of rifampicin for these drug-resistant strains. SQ109 interacts Synergistically with isoniazid and rifampicin, two of the most important front-line TB drugs. This finding supports efforts to further evaluate new combination therapies containing SQ109 in experimental animal models of TB that emulate future clinical trial studies in humans. JF - The Journal of antimicrobial chemotherapy AU - Chen, Ping AU - Gearhart, Jackie AU - Protopopova, Marina AU - Einck, Leo AU - Nacy, Carol A AD - Sequella, Inc., 9610 Medical Center Drive Suite 200, Rockville, MD 20850, USA. chenpi@niaid.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 332 EP - 337 VL - 58 IS - 2 SN - 0305-7453, 0305-7453 KW - Antitubercular Agents KW - 0 KW - Ethylenediamines KW - N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine KW - Adamantane KW - PJY633525U KW - Isoniazid KW - V83O1VOZ8L KW - Rifampin KW - VJT6J7R4TR KW - Index Medicus KW - Isoniazid -- pharmacology KW - Drug Resistance, Bacterial -- drug effects KW - Humans KW - Rifampin -- pharmacology KW - Drug Synergism KW - Microbial Sensitivity Tests KW - Adamantane -- pharmacology KW - Antitubercular Agents -- pharmacology KW - Mycobacterium tuberculosis -- drug effects KW - Ethylenediamines -- pharmacology KW - Adamantane -- analogs & derivatives UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68652327?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+antimicrobial+chemotherapy&rft.atitle=Synergistic+interactions+of+SQ109%2C+a+new+ethylene+diamine%2C+with+front-line+antitubercular+drugs+in+vitro.&rft.au=Chen%2C+Ping%3BGearhart%2C+Jackie%3BProtopopova%2C+Marina%3BEinck%2C+Leo%3BNacy%2C+Carol+A&rft.aulast=Chen&rft.aufirst=Ping&rft.date=2006-08-01&rft.volume=58&rft.issue=2&rft.spage=332&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+antimicrobial+chemotherapy&rft.issn=03057453&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-11 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic variation in N-acetyltransferase 1 (NAT1) and 2 (NAT2) and risk of non-Hodgkin lymphoma. AN - 68644202; 16847422 AB - Animal studies suggest that lymphomagenesis can be induced by exposure to carcinogenic aromatic and heterocyclic amines found in diet, cigarette smoke and the environment, but human epidemiologic investigations of these exogenous exposures have yielded conflicting results. As part of our evaluation of the role of aromatic and heterocyclic amines, which are metabolized by N-acetyltransferase (NAT) enzymes, in the etiology of non-Hodgkin lymphoma (NHL), we examined NHL risk in relation to genetic variation in NAT1 and NAT2 and exposure to cigarette smoke and dietary heterocyclic amines and mutagens. We genotyped 10 common single nucleotide polymorphisms (SNPs) in NAT1 and NAT2 among 1136 cases and 922 controls from a population-based case-control study in four geographical areas of the USA. Relative risk of NHL for NAT1 and NAT2 genotypes, NAT2 acetylation phenotype, and exposure to cigarette smoke and dietary heterocyclic amines and mutagens was estimated using odds ratios (ORs) and 95% confidence intervals (CIs) derived from unconditional logistic regression models. We observed increased risk of NHL among individuals with the NAT1*10/*10 genotype compared with individuals with other NAT1 genotypes (OR = 1.60, 95% CI = 1.04-2.46, P = 0.03). We also observed increased NHL risk in a dose-dependent model among NAT2 intermediate- and rapid-acetylators compared with slow-acetylators, although only the trend was statistically significant (intermediate: OR = 1.18, 95% CI = 0.97-1.44, P = 0.1; rapid: OR = 1.43, 95% CI = 0.97-2.14, P = 0.07; P for linear trend = 0.03). Compared with non-smokers, NHL risk estimates for current cigarette smoking were increased only among NAT2 intermediate/rapid-acetylators (OR = 2.44, 95% CI = 1.15-5.20, P = 0.02). Our data provide evidence that NAT1 and NAT2 genotypes are associated with NHL risk and support a contributory role for carcinogenic aromatic and/or heterocyclic amines in the multi-factorial etiology of NHL. JF - Pharmacogenetics and genomics AU - Morton, Lindsay M AU - Schenk, Maryjean AU - Hein, David W AU - Davis, Scott AU - Zahm, Shelia Hoar AU - Cozen, Wendy AU - Cerhan, James R AU - Hartge, Patricia AU - Welch, Robert AU - Chanock, Stephen J AU - Rothman, Nathaniel AU - Wang, Sophia S AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. mortonli@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 537 EP - 545 VL - 16 IS - 8 SN - 1744-6872, 1744-6872 KW - Isoenzymes KW - 0 KW - Arylamine N-Acetyltransferase KW - EC 2.3.1.5 KW - N-acetyltransferase 1 KW - NAT2 protein, human KW - Index Medicus KW - Phenotype KW - Genotype KW - Polymorphism, Single Nucleotide KW - Risk Factors KW - Humans KW - Adult KW - Case-Control Studies KW - Aged KW - Middle Aged KW - Male KW - Female KW - Lymphoma, Non-Hodgkin -- genetics KW - Genetic Variation KW - Isoenzymes -- genetics KW - Arylamine N-Acetyltransferase -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68644202?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Pharmacogenetics+and+genomics&rft.atitle=Genetic+variation+in+N-acetyltransferase+1+%28NAT1%29+and+2+%28NAT2%29+and+risk+of+non-Hodgkin+lymphoma.&rft.au=Morton%2C+Lindsay+M%3BSchenk%2C+Maryjean%3BHein%2C+David+W%3BDavis%2C+Scott%3BZahm%2C+Shelia+Hoar%3BCozen%2C+Wendy%3BCerhan%2C+James+R%3BHartge%2C+Patricia%3BWelch%2C+Robert%3BChanock%2C+Stephen+J%3BRothman%2C+Nathaniel%3BWang%2C+Sophia+S&rft.aulast=Morton&rft.aufirst=Lindsay&rft.date=2006-08-01&rft.volume=16&rft.issue=8&rft.spage=537&rft.isbn=&rft.btitle=&rft.title=Pharmacogenetics+and+genomics&rft.issn=17446872&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-26 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Pharmacogenet Genomics. 2005 Aug;15(8):535-46 [16006997] Mutat Res. 2005 Jul 1;574(1-2):156-72 [15914214] Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2449-53 [16214931] Carcinogenesis. 2006 Feb;27(2):293-7 [16113054] Oncogene. 2006 Mar 13;25(11):1649-58 [16550165] J Natl Cancer Inst. 1999 Oct 20;91(20):1751-8 [10528026] Cancer Epidemiol Biomarkers Prev. 2000 Jan;9(1):29-42 [10667461] Pharmacogenetics. 2000 Jun;10(4):291-2 [10862519] Cancer Epidemiol Biomarkers Prev. 2001 Jun;10(6):687-96 [11401920] Pharmacogenomics. 2002 Jan;3(1):19-30 [11966400] Br J Haematol. 2002 Aug;118(2):477-81 [12139735] Mutat Res. 2002 Sep 30;506-507:65-77 [12351146] Carcinogenesis. 2003 Mar;24(3):483-9 [12663508] Nucleic Acids Res. 2004 Jan 1;32(Database issue):D528-32 [14681474] Cancer Epidemiol Biomarkers Prev. 2004 Sep;13(9):1415-21 [15342441] Cancer Epidemiol Biomarkers Prev. 2004 Oct;13(10):1665-76 [15466985] Jpn J Cancer Res. 1989 Dec;80(12):1176-8 [2516847] DNA Cell Biol. 1990 Apr;9(3):193-203 [2340091] Carcinogenesis. 1993 Aug;14(8):1633-8 [8353847] Arch Toxicol. 1994;68(2):129-33 [8179482] Blood. 1994 Sep 1;84(5):1361-92 [8068936] Cancer Res. 1995 Nov 15;55(22):5226-9 [7585580] JAMA. 1996 May 1;275(17):1315-21 [8614116] Carcinogenesis. 1996 Oct;17(10):2221-7 [8895492] Carcinogenesis. 1997 May;18(5):975-80 [9163683] Pharmacogenetics. 1998 Feb;8(1):55-66 [9511182] Pharmacogenetics. 1998 Feb;8(1):67-72 [9511183] Leuk Res. 1998 May;22(5):445-52 [9652731] Cancer Epidemiol Biomarkers Prev. 1999 Mar;8(3):233-9 [10090301] Carcinogenesis. 1999 Jul;20(7):1225-9 [10383893] Pol J Pharmacol. 2004 Jul-Aug;56(4):445-9 [15520499] Bioinformatics. 2005 Jan 15;21(2):263-5 [15297300] Br J Haematol. 2005 Mar;128(5):610-5 [15725081] Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):925-33 [15824165] Lancet. 2005 Aug 20-26;366(9486):649-59 [16112301] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. AN - 68638663; 16644904 AB - Elevations in plasma serotonin (5-HT) have been implicated in the pathogenesis of cardiac and pulmonary disease. Normally, plasma 5-HT concentrations are kept low by transporter-mediated uptake of 5-HT into platelets and by metabolism to 5-hydroxyindoleacetic acid (5-HIAA). Many abused drugs (e.g., substituted amphetamines) and prescribed medications (e.g., fluoxetine) target 5-HT transporters and could thereby influence circulating 5-HT. We evaluated the effects of amphetamines analogs [(+/-)-fenfluramine, (+/-)-3,4-methylenedioxymethamphetamine, (+)-methamphetamine, (+)-amphetamine, phentermine] on extracellular levels (i.e., plasma levels) of 5-HT and 5-HIAA in blood from catheterized rats. Effects of the 5-HT uptake blocker fluoxetine were examined for comparison. Drugs were tested in vivo and in vitro; plasma indoles were measured using a novel microdialysis method in whole blood. We found that baseline dialysate levels of 5-HT are approximately 0.22 nM, and amphetamine analogs evoke large dose-dependent increases in plasma 5-HT ranging from 4 to 20 nM. The ability of drugs to elevate plasma 5-HT is positively correlated with their potency as 5-HT transporter substrates. Fluoxetine produced small, but significant, increases in plasma 5-HT. Although the drug-evoked 5-HT concentrations are below the micromolar levels required for contraction of pulmonary arteries, they approach concentrations reported to stimulate mitogenesis in pulmonary artery smooth muscle cells. Additional studies are needed to determine the effects of chronic administration of amphetamines on circulating 5-HT. JF - The Journal of pharmacology and experimental therapeutics AU - Zolkowska, Dorota AU - Rothman, Richard B AU - Baumann, Michael H AD - Clinical Psychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 604 EP - 610 VL - 318 IS - 2 SN - 0022-3565, 0022-3565 KW - Amphetamines KW - 0 KW - Central Nervous System Stimulants KW - Indicators and Reagents KW - Mitogens KW - Serotonin Plasma Membrane Transport Proteins KW - Serotonin Uptake Inhibitors KW - Fluoxetine KW - 01K63SUP8D KW - Serotonin KW - 333DO1RDJY KW - Methamphetamine KW - 44RAL3456C KW - Hydroxyindoleacetic Acid KW - 54-16-0 KW - Phentermine KW - C045TQL4WP KW - N-Methyl-3,4-methylenedioxyamphetamine KW - KE1SEN21RM KW - Dextroamphetamine KW - TZ47U051FI KW - Index Medicus KW - Mitogens -- pharmacology KW - Animals KW - Fluoxetine -- pharmacology KW - Serotonin Plasma Membrane Transport Proteins -- metabolism KW - Dose-Response Relationship, Drug KW - Hydroxyindoleacetic Acid -- metabolism KW - Muscle, Smooth, Vascular -- drug effects KW - N-Methyl-3,4-methylenedioxyamphetamine -- pharmacology KW - Dextroamphetamine -- pharmacology KW - Stimulation, Chemical KW - Rats KW - Microdialysis KW - Rats, Sprague-Dawley KW - Phentermine -- pharmacology KW - Methamphetamine -- pharmacology KW - Muscle, Smooth, Vascular -- cytology KW - Serotonin Uptake Inhibitors -- pharmacology KW - Electrochemistry KW - Male KW - Central Nervous System Stimulants -- pharmacology KW - Lung Diseases -- chemically induced KW - Central Nervous System Stimulants -- toxicity KW - Amphetamines -- pharmacology KW - Heart Diseases -- chemically induced KW - Serotonin -- blood KW - Lung Diseases -- metabolism KW - Heart Diseases -- metabolism KW - Amphetamines -- toxicity UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68638663?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Amphetamine+analogs+increase+plasma+serotonin%3A+implications+for+cardiac+and+pulmonary+disease.&rft.au=Zolkowska%2C+Dorota%3BRothman%2C+Richard+B%3BBaumann%2C+Michael+H&rft.aulast=Zolkowska&rft.aufirst=Dorota&rft.date=2006-08-01&rft.volume=318&rft.issue=2&rft.spage=604&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-31 N1 - Date created - 2006-07-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Alterations in the rat serum proteome during liver injury from acetaminophen exposure. AN - 68634750; 16687475 AB - Changes in the serum proteome were identified during early, fulminant, and recovery phases of liver injury from acetaminophen in the rat. Male F344 rats received a single, noninjury dose or a high, injury-producing dose of acetaminophen for evaluation at 6 to 120 h. Two-dimensional gel electrophoresis of immunodepleted serum separated approximately 800 stained proteins per sample from which differentially expressed proteins were identified by mass spectrometry. Serum alanine aminotransferase/aspartate aminotransferase levels and histopathology revealed the greatest liver damage at 24 and 48 h after high-dose acetaminophen corresponding to the time of greatest serum protein alterations. After 24 h, 68 serum proteins were significantly altered of which 23 proteins were increased by >5-fold and 20 proteins were newly present compared with controls. Only minimal changes in serum proteins were noted at the low dose without any histopathology. Of the 54 total protein isoforms identified by mass spectrometry, gene ontology processes for 38 unique serum proteins revealed involvement of acute phase response, coagulation, protein degradation, intermediary metabolism, and various carrier proteins. Elevated serum tumor necrosis factor-alpha from 24 to 48 h suggested a mild inflammatory response accompanied by increased antioxidant capability demonstrated by increased serum catalase activity. Antibody array and enzyme-linked immunosorbent assay analyses also showed elevation in the chemokine monocyte chemoattractant protein-1 and the metalloprotease inhibitor tissue inhibitor of metalloproteinases-1 during this same period of liver injury. This study demonstrates that serum proteome alterations probably reflect both liver damage and a concerted, complex response of the body for organ repair and recovery during acute hepatic injury. JF - The Journal of pharmacology and experimental therapeutics AU - Merrick, B Alex AU - Bruno, Maribel E AU - Madenspacher, Jennifer H AU - Wetmore, Barbara A AU - Foley, Julie AU - Pieper, Rembert AU - Zhao, Ming AU - Makusky, Anthony J AU - McGrath, Andrew M AU - Zhou, Jeff X AU - Taylor, John AU - Tomer, Kenneth B AD - Proteomics Group, National Institute of Environmental Health Sciences, D2-04, P.O. Box 12233, Research Triangle Park, NC 27709, USA. merrick@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 792 EP - 802 VL - 318 IS - 2 SN - 0022-3565, 0022-3565 KW - Analgesics, Non-Narcotic KW - 0 KW - Blood Proteins KW - Proteome KW - Acetaminophen KW - 362O9ITL9D KW - Catalase KW - EC 1.11.1.6 KW - Aspartate Aminotransferases KW - EC 2.6.1.1 KW - Alanine Transaminase KW - EC 2.6.1.2 KW - Index Medicus KW - Rats KW - Mass Spectrometry KW - Aspartate Aminotransferases -- blood KW - Animals KW - Rats, Inbred F344 KW - Blotting, Western KW - Alanine Transaminase -- blood KW - Electrophoresis, Polyacrylamide Gel KW - Catalase -- blood KW - Image Processing, Computer-Assisted KW - Male KW - Proteome -- genetics KW - Blood Proteins -- biosynthesis KW - Proteome -- metabolism KW - Blood Proteins -- metabolism KW - Chemical and Drug Induced Liver Injury -- metabolism KW - Proteome -- chemistry KW - Blood Proteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68634750?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.atitle=Alterations+in+the+rat+serum+proteome+during+liver+injury+from+acetaminophen+exposure.&rft.au=Merrick%2C+B+Alex%3BBruno%2C+Maribel+E%3BMadenspacher%2C+Jennifer+H%3BWetmore%2C+Barbara+A%3BFoley%2C+Julie%3BPieper%2C+Rembert%3BZhao%2C+Ming%3BMakusky%2C+Anthony+J%3BMcGrath%2C+Andrew+M%3BZhou%2C+Jeff+X%3BTaylor%2C+John%3BTomer%2C+Kenneth+B&rft.aulast=Merrick&rft.aufirst=B&rft.date=2006-08-01&rft.volume=318&rft.issue=2&rft.spage=792&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+pharmacology+and+experimental+therapeutics&rft.issn=00223565&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-31 N1 - Date created - 2006-07-14 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Clin Chem. 2005 Oct;51(10):1796-803 [16099942] J Clin Pharmacol. 2005 Oct;45(10):1165-71 [16172181] J Proteome Res. 2005 Sep-Oct;4(5):1814-25 [16212437] Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65 [16081117] Proteomics. 2003 Oct;3(10):1835-62 [14625847] Brain Res Bull. 2003 Dec 15;62(2):101-6 [14638383] Toxicol Sci. 2004 Jul;80(1):193-202 [15084756] J Immunol. 2004 Jul 15;173(2):747-54 [15240660] Hepatology. 2004 Nov;40(5):1170-9 [15486922] Biochim Biophys Acta. 2004 Nov 5;1690(3):258-64 [15511633] Acta Med Scand. 1973 Jan-Feb;193(1-2):113-8 [4145127] J Lab Clin Med. 1985 May;105(5):619-24 [3989355] J Appl Physiol (1985). 1991 Nov;71(5):1903-6 [1761490] N Engl J Med. 1992 May 14;326(20):1335-41 [1314333] Am J Pathol. 1994 Jan;144(1):129-40 [8291602] Toxicol Pathol. 1996 Jan-Feb;24(1):112-8 [8839288] J Pharmacol Exp Ther. 1999 May;289(2):1176-84 [10215702] Drug Metab Rev. 2004 Oct;36(3-4):805-22 [15554248] Gastroenterology. 2004 Dec;127(6):1760-74 [15578514] Hepatology. 2005 Apr;41(4):857-67 [15726641] Annu Rev Pharmacol Toxicol. 2005;45:177-202 [15822174] Clin Chem. 2005 May;51(5):810-24 [15774573] Hepatology. 1999 Nov;30(5):1159-66 [10534336] Toxicol Sci. 2000 Apr;54(2):509-16 [10774834] Electrophoresis. 2000 Jun;21(11):2148-61 [10892726] Biochem Biophys Res Commun. 2001 Mar 23;282(1):321-8 [11264010] Clin Chem. 2001 May;47(5):946-8 [11325904] Proteomics. 2001 Mar;1(3):377-96 [11680884] Toxicol Sci. 2002 Jan;65(1):135-50 [11752693] Hepatology. 2002 May;35(5):1093-103 [11981759] DNA Cell Biol. 2002 Apr;21(4):297-306 [12042069] Lab Anim. 2002 Jul;36(3):313-21 [12144742] Proteomics. 2003 Jul;3(7):1345-64 [12872236] Toxicol Appl Pharmacol. 2003 Oct 15;192(2):119-30 [14550746] Drug Metab Dispos. 2003 Dec;31(12):1499-506 [14625346] Basic Clin Pharmacol Toxicol. 2005 Jul;97(1):8-14 [15943753] Chem Res Toxicol. 2005 Jun;18(6):924-33 [15962927] Proteomics. 2005 Aug;5(13):3226-45 [16104056] Clin Med Res. 2004 May;2(2):129-31 [15931347] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemopreventive potential of diallylsulfide, lycopene and theaflavin during chemically induced colon carcinogenesis in rat colon through modulation of cyclooxygenase-2 and inducible nitric oxide synthase pathways. AN - 68632524; 16835502 AB - Chemoprevention of colorectal cancer has become essential in the modern industrialized world as cancer of the large bowel has become one of the major causes of cancer mortality, second only to lung cancer. Colon cancer integrates lifestyle factors and multistep genetic alterations, and without preventive intervention, a substantial part of the population is likely to develop colorectal cancer at some point during their lives. Diet and nutrition clearly play a role in the etiology of colon cancer. Inhibitory activity of aqueous suspensions of garlic, tomato and black tea was tested on azoxymethane-induced colon carcinogenesis in Sprague-Dawley rats during earlier studies. In the present study, the protective activity of diallylsulfide and lycopene and theaflavin, important antioxidative ingredients of garlic, tomato and black tea, respectively, was assessed during colon carcinogenesis. The effect was observed on aberrant crypt foci, the preneoplastic lesion. As inhibition of cyclooxygenase-2 and inducible nitric oxide synthase activities is correlated with the prevention of colon cancer, the study continues with the determination of the change in the expression of these proteins. Following treatment, significant reduction in the incidences of aberrant crypt foci (by 43.65% in diallylsulfide, 57.39% in lycopene and 66.08% in theaflavin group) was observed, which was in accordance with the reduced expression of cyclooxygenase-2 and inducible nitric oxide synthase. The effect of the intact source was found to be more pronounced than their components used separately. JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) AU - Sengupta, Archana AU - Ghosh, Samit AU - Das, Rajat Kumar AU - Bhattacharjee, Shamee AU - Bhattacharya, Sudin AD - Department of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Kolkata, India. archana_sen@yahoo.com Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 301 EP - 305 VL - 15 IS - 4 SN - 0959-8278, 0959-8278 KW - Allyl Compounds KW - 0 KW - Anticarcinogenic Agents KW - Biflavonoids KW - Sulfides KW - theaflavin KW - 1IA46M0D13 KW - Carotenoids KW - 36-88-4 KW - allyl sulfide KW - 60G7CF7CWZ KW - Catechin KW - 8R1V1STN48 KW - Nitric Oxide Synthase Type II KW - EC 1.14.13.39 KW - Cyclooxygenase 2 KW - EC 1.14.99.1 KW - Azoxymethane KW - MO0N1J0SEN KW - lycopene KW - SB0N2N0WV6 KW - Index Medicus KW - Rats KW - Animals KW - Rats, Sprague-Dawley KW - Anticarcinogenic Agents -- pharmacology KW - Signal Transduction KW - Male KW - Colon -- drug effects KW - Biflavonoids -- pharmacology KW - Allyl Compounds -- pharmacology KW - Nitric Oxide Synthase Type II -- metabolism KW - Cyclooxygenase 2 -- metabolism KW - Colonic Neoplasms -- prevention & control KW - Colonic Neoplasms -- chemically induced KW - Carotenoids -- pharmacology KW - Sulfides -- pharmacology KW - Catechin -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68632524?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.atitle=Chemopreventive+potential+of+diallylsulfide%2C+lycopene+and+theaflavin+during+chemically+induced+colon+carcinogenesis+in+rat+colon+through+modulation+of+cyclooxygenase-2+and+inducible+nitric+oxide+synthase+pathways.&rft.au=Sengupta%2C+Archana%3BGhosh%2C+Samit%3BDas%2C+Rajat+Kumar%3BBhattacharjee%2C+Shamee%3BBhattacharya%2C+Sudin&rft.aulast=Sengupta&rft.aufirst=Archana&rft.date=2006-08-01&rft.volume=15&rft.issue=4&rft.spage=301&rft.isbn=&rft.btitle=&rft.title=European+journal+of+cancer+prevention+%3A+the+official+journal+of+the+European+Cancer+Prevention+Organisation+%28ECP%29&rft.issn=09598278&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-18 N1 - Date created - 2006-07-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NTP Toxicity Study Report on the atmospheric characterization, particle size, chemical composition, and workplace exposure assessment of cellulose insulation (CELLULOSEINS). AN - 68240019; 17160106 AB - Cellulose insulation (CI) is a type of thermal insulation produced primarily from recycled newspapers. The newspapers are shredded, milled, and treated with fire-retardant chemicals. The blowing process for installing CI generates a significant quantity of airborne material that presents a potential inhalation hazard to workers. CI was selected for study based upon the high production volume, the potential for widespread human exposure, and a lack of toxicity data; insufficient information was available to determine whether inhalation studies in laboratory animals were technically feasible or necessary. Studies were conducted to characterize the chemical and physical properties of CI aerosols, to evaluate the potential acute pulmonary toxicity of CI, and to assess occupational exposure of CI installers. Workplace exposure assessments were conducted in collaboration with the National Institute for Occupational Safety and Health (NIOSH, 2001). Chemical analyses were performed on samples of bulk CI from four major United States manufacturers. All samples of the bulk CI were found to contain primarily amorphous cellulose (60% to 65%) with a smaller crystalline component (35% to 40%). The crystalline phase was primarily native cellulose (75% to 85%) with a minor amount of cellulose nitrate (15% to 25%). Elemental analyses of acid digests of CI materials indicated that the major components (>0.1% by weight) included aluminum, boron, calcium, sodium, and sulfur. An acid-insoluble residue present in all four materials (3% to 5% of original sample weight) was found to consist primarily of aluminum silicate hydroxide (kaolinite; approximately 85%) with minor amounts (<5% each) of magnesium silicate hydroxide (talc), potassium aluminum silicate hydroxide (muscovite), and titanium oxide (rutile). Solvent extracts of the bulk materials were analyzed for organic components by gas chromatography with flame ionization detection. Analyses revealed a mass of poorly resolved peaks. Because of the very low concentrations, further quantitative and qualitative analyses were not performed. An aerosol generation system was designed to separate CI particles based upon aerodynamic size and to simulate the process used during CI installation at work sites. Less than 0.1% of each of the CI samples was collected as the small respirable particle fraction. The mean equivalent diameter of respirable particles ranged from 0.6 to 0.7 mum. The numbers of fibers in the respirable fractions ranged from 9.7 x 103 to 1.4 x 106 fibers/g of CI. The respirable particle fractions did not contain cellulose material and consisted mainly of fire retardants and small quantities of clays. The respirable fraction from one CI sample was administered by intratracheal instillation to male Fischer 344 rats at doses of 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg body weight; the bronchoalveolar lavage (BAL) fluid cellularity was evaluated 3 days later. Based upon the relatively mild severity of the inflammatory response, a dose of 5 mg/kg body weight was selected for use in a subsequent 28-day study. Rats received CI, titanium dioxide (particle controls), or sterile saline (controls). BAL fluid was evaluated 1, 3, 7, 14, and 28 days after instillation, and lung histopathology was evaluated 14 and 28 days after treatment. CI caused a greater influx of inflammatory cells than titanium dioxide and caused significant increases in BAL fluid protein and lactate dehydrogenase. These CI-induced changes in BAL fluid parameters were transient and by day 14 were not significantly different than those observed in rats treated with titanium dioxide or phosphate-buffered saline. Unlike titanium dioxide, CI treatment caused a minimal to mild nonprogressive, minimally fibrosing granulomatous pneumonitis characterized by nodular foci of macrophages and giant cells. These results indicated that few respirable particles or fibers are likely generated during the CI application and that the acute pulmonary toxicity is minimal. The CI exposure assessment was conducted with 10 contractors located across the United States. Air samples of total dust and respirable dust were collected for scanning electron microscopy (SEM) to characterize any fibers in the dust. Two SEM air samples for each day of CI activities were collected from the installer and hopper operator. Bulk CI samples were collected and analyzed for metal, boron, and sulfate content. Real-time and video exposure monitoring was conducted to further characterize the CI dust and workers' exposures. The exposure assessment also included a medical component. Investigators collected 175 personal breathing zone (PBZ) total dust, 106 area total dust, and 90 area respirable dust air samples during CI-related activities at the 10 contractor sites. Twenty-six employees' total dust 8-hour time-weighted averages (TWAs) exceeded the Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL) of 15 mg/m3, and 42 exceeded the American Conference of Governmental Industrial Hygienists (ACGIH) threshold-limit value (TLV) of 10 mg/m3. Respirable dust air sampling and real-time monitoring with particle size discrimination indicated low levels of respirable dust generation. The SEM analyses revealed that fibers were an average 28 mum in length and ranged from 5 mum to 150 mum. CI installers' PBZ total dust, area total dust, and area respirable dust air samples were all significantly higher during dry attic applications than wet attic applications (P<0.01). Conversely, the hopper operators' total dust exposures were significantly higher during wet wall and ceiling applications than dry wall and ceiling applications (P=0.02). Analyses of variance tests revealed that exposure concentrations in total dust air samples collected in the PBZ of all CI workers, including installers working in attics, installers during wall applications, hopper operators during attic applications, and hopper operators during wall and ceiling applications, varied significantly during dry applications (P<0.01). The respirable dust air samples collected in attic areas, hopper areas during attic applications, and hopper areas during wall and ceiling applications also differed significantly during dry applications (P=0.03). Twenty-three workers participated in the medical phase of the investigation. The workers completed medical and work history questionnaires, performed serial peak flow tests, and completed multiple acute symptom surveys. The medical questionnaires indicated respiratory, nasal, and skin symptoms that employees attributed to CI exposure. The most common symptoms reported while working with CI included nasal symptoms (35%), eye symptoms (35%), and morning phlegm production (25%). There was a temporal association between CI exposure and eye symptoms, but there was little evidence of lower respiratory system health conditions associated with CI exposure. Chemical analyses of the four bulk CI samples revealed only minor differences in additives. The major elemental components detected were aluminum, boron, calcium, sodium, and sulfur, but they were attributed to the fire retardants aluminum sulfate, boric acid, and sodium sulfate. For all four CI samples, less than 0.1% by weight was collected as the small respirable particle fraction. The fractions consisted mainly of fire retardants and smaller quantities of clays and did not contain cellulose material. Intratracheal instillation of the respirable fraction in rats produced minimal to mild inflammatory responses in the lungs with no increase in severity by 28 days after dosage. Although a significant increase in lung collagen was detected at day 28 in treated rats, microscopic evaluation revealed only a minimal to mild increase in collagen fibrils associated with granulomatous nodules. The results of these studies indicated that few respirable particles or fibers are generated during the aerosolization of CI, and that even at very high doses of respirable CI particles, acute pulmonary toxicity is minimal. These results are supported by the NIOSH workplace exposure assessment conducted on CI workers. Based on the air sample data collected from the 10 contractor site visits, there is a potential for overexposure to CI; however, respirable dust concentrations were typically low. There was increased potential for 8-hour TWAs exceeding the OSHA PEL for total and respirable dust when employees were involved in CI application activities for longer periods of time. There was evidence of work-related eye and mucous membrane irritation among some workers, which were possibly caused by the additives present in CI, such as boric acid. There was little evidence of lower respiratory system health conditions associated with CI exposure. Based upon the results of the CI chemical characterization studies, the pulmonary toxicity study, and the worksite exposure assessment, the NTP concluded that additional studies of CI in laboratory animals are not warranted at this time. However, the animal pulmonary toxicity studies and worker health surveys focused on acute CI exposures and do not preclude the possibility of toxicity resulting from chronic exposure. Although exposure concentrations of respirable CI particulate matter were low, additional information is needed on the biodurability and reactivity of CI particles and fibers in the respiratory tract. CI should continue to be regarded as a nuisance dust, and workers should continue to wear protective masks to prevent inhalation exposure to CI dusts. JF - Toxicity report series AU - Morgan, Daniel L AD - National Toxicology Program, National Institute of Environmental Health Sciences, PO Box 12233, Research Triangle Park, NC 27709, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 1 EP - 62, A1-C2 IS - 74 SN - 1521-4621, 1521-4621 KW - Aerosols KW - 0 KW - Air Pollutants, Occupational KW - Dust KW - Cellulose KW - 9004-34-6 KW - Index Medicus KW - Threshold Limit Values KW - Respiratory Function Tests KW - Dust -- analysis KW - Particle Size KW - Humans KW - Surveys and Questionnaires KW - Aerosols -- chemistry KW - Microscopy, Electron, Scanning KW - Inhalation Exposure -- analysis KW - Air Pollutants, Occupational -- analysis KW - Cellulose -- toxicity KW - Cellulose -- chemistry KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68240019?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicity+report+series&rft.atitle=NTP+Toxicity+Study+Report+on+the+atmospheric+characterization%2C+particle+size%2C+chemical+composition%2C+and+workplace+exposure+assessment+of+cellulose+insulation+%28CELLULOSEINS%29.&rft.au=Morgan%2C+Daniel+L&rft.aulast=Morgan&rft.aufirst=Daniel&rft.date=2006-08-01&rft.volume=&rft.issue=74&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicity+report+series&rft.issn=15214621&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Translational approaches using metastasis suppressor genes. AN - 68233278; 16944301 AB - Cancer metastasis is a significant contributor to breast cancer patient morbidity and mortality. In order to develop new anti-metastatic therapies, we need to understand the biological and biochemical mechanisms of metastasis. Toward these efforts, we and others have studied metastasis suppressor genes, which halt metastasis in vivo without affecting primary tumor growth. The first metastasis suppressor gene identified was nm23, also known as NDP kinase. Nm23 represents the most widely validated metastasis suppressor gene, based on transfection and knock-out mouse strategies. The biochemical mechanism of metastasis suppression via Nm23 is unknown and likely complex. Two potential mechanisms include binding proteins and a histidine kinase activity. Elevation of Nm23 expression in micrometastatic tumor cells may constitute a translational strategy for the limitation of metastatic colonization in high risk cancer patients. To date, medroxyprogesterone acetate (MPA) has been identified as a candidate compound for clinical testing. JF - Journal of bioenergetics and biomembranes AU - Palmieri, Diane AU - Horak, Christine E AU - Lee, Jong-Heun AU - Halverson, Douglas O AU - Steeg, Patricia S AD - Women's Cancers Section, Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Building 37, Room 1122, NIH, Bethesda, MD 20892, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 151 EP - 161 VL - 38 IS - 3-4 SN - 0145-479X, 0145-479X KW - NM23 Nucleoside Diphosphate Kinases KW - 0 KW - Medroxyprogesterone Acetate KW - C2QI4IOI2G KW - Protein Kinases KW - EC 2.7.- KW - Histidine Kinase KW - EC 2.7.13.1 KW - NME1 protein, human KW - EC 2.7.4.6 KW - Nme1 protein, mouse KW - Nucleoside-Diphosphate Kinase KW - Index Medicus KW - Mutagenesis, Site-Directed KW - Protein Kinases -- metabolism KW - Animals KW - Humans KW - Mice KW - Cell Line, Tumor KW - Mice, Knockout KW - Gene Expression Regulation, Neoplastic KW - Nucleoside-Diphosphate Kinase -- genetics KW - Neoplasm Metastasis -- genetics KW - Genes, Tumor Suppressor KW - Neoplasm Metastasis -- prevention & control KW - Nucleoside-Diphosphate Kinase -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68233278?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+bioenergetics+and+biomembranes&rft.atitle=Translational+approaches+using+metastasis+suppressor+genes.&rft.au=Palmieri%2C+Diane%3BHorak%2C+Christine+E%3BLee%2C+Jong-Heun%3BHalverson%2C+Douglas+O%3BSteeg%2C+Patricia+S&rft.aulast=Palmieri&rft.aufirst=Diane&rft.date=2006-08-01&rft.volume=38&rft.issue=3-4&rft.spage=151&rft.isbn=&rft.btitle=&rft.title=Journal+of+bioenergetics+and+biomembranes&rft.issn=0145479X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-27 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Serial analysis of gene expression in the rat striatum following methamphetamine administration. AN - 68149263; 17105900 AB - Methamphetamine (METH), a highly addictive drug, can cause degeneration of monoaminergic terminals and neuronal apoptosis in the mammalian brain. In the present article, we have used serial analysis of gene expression (SAGE) to investigate patterns of gene expression in the striata of rats that were given a neurotoxic dose of the drug. SAGE libraries were generated from animals treated with either saline or METH (40 mg/kg) and sacrificed 2 h later. A total of 315 transcripts were differentially expressed between the two libraries (P < 0.05), with 179 (56%) being upregulated and 136 (44%) being downregulated by the METH injection. Of these, CAATT enhancer-binding protein homologous protein (CHOP)/GADD153 (growth arrest- and DNA damage-inducible gene 153) was found to be upregulated by about threefold. Analysis of the expression of genes downstream of CHOP (DOCs) revealed significant METH-induced increases in their expression. Because DOC1 is an analog of carbonic anhydrase (CA) which is involved in the interconversion between carbon dioxide and the bicarbonate ion, we also measured the effects of METH on the expression of several CAs. These were significantly upregulated by METH in a time-dependent fashion. These results indicate that METH toxicity is mediated, in part, by drug-induced perturbations of physiological processes that are dependent on normal pH and CO(2) homeostasis. JF - Annals of the New York Academy of Sciences AU - Cai, Ning Sheng AU - McCoy, Michael T AU - Ladenheim, Bruce AU - Lyles, Johnalyn AU - Ali, Syed F AU - Cadet, Jean Lud AD - Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, National Institute of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA. jcadet@intra.nida.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 13 EP - 30 VL - 1074 SN - 0077-8923, 0077-8923 KW - Calcium-Binding Proteins KW - 0 KW - Ddit3 protein, rat KW - Dopamine Agents KW - Nerve Tissue Proteins KW - Transcription Factor CHOP KW - 147336-12-7 KW - Methamphetamine KW - 44RAL3456C KW - Index Medicus KW - Rats KW - Gene Expression Profiling KW - Animals KW - Rats, Sprague-Dawley KW - Base Sequence KW - Transcription Factor CHOP -- metabolism KW - Oligonucleotide Array Sequence Analysis KW - Down-Regulation KW - Molecular Sequence Data KW - Nerve Tissue Proteins -- metabolism KW - Up-Regulation KW - Calcium-Binding Proteins -- metabolism KW - Corpus Striatum -- metabolism KW - Dopamine Agents -- pharmacology KW - Methamphetamine -- pharmacology KW - Corpus Striatum -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68149263?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Serial+analysis+of+gene+expression+in+the+rat+striatum+following+methamphetamine+administration.&rft.au=Cai%2C+Ning+Sheng%3BMcCoy%2C+Michael+T%3BLadenheim%2C+Bruce%3BLyles%2C+Johnalyn%3BAli%2C+Syed+F%3BCadet%2C+Jean+Lud&rft.aulast=Cai&rft.aufirst=Ning&rft.date=2006-08-01&rft.volume=1074&rft.issue=&rft.spage=13&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-10 N1 - Date created - 2006-11-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Animal models of pheochromocytoma including NIH initial experience. AN - 68145084; 17102099 AB - Mouse models have been used to study the mechanisms underlying the carcinogenesis of a wide variety of human cancer. A considerable number of mouse and rat models, used for the study of elementary tumorgenic mechanisms, were found to develop pheochromocytomas. Some of these models resemble hereditary syndrome-related pheochromocytoma in humans and some may serve as a new starting point for human pheochromocytoma research. Recently, we generated a model of catecholamine-producing metastatic pheochromocytoma in athymic nude mice using tail-vein injection of mouse pheochromocytoma cells (MPCs). This and alternative animal models of metastatic pheochromocytoma are promising avenues in preclinical studies to evaluate new therapeutic approaches for malignant pheochromocytoma. JF - Annals of the New York Academy of Sciences AU - Ohta, Shoichiro AU - Lai, Edwin W AU - Taniguchi, Shun'Ichiro AU - Tischler, Arthur S AU - Alesci, Salvatore AU - Pacak, Karel AD - Reproductive Biology and Medicine Branch, National Institute of Child Health and Human Development, NIH, Building 10, CRC, Room 1E-3141, 10 Center Drive MSC-1109, Bethesda, MD 20892-1109, USA. Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 300 EP - 305 VL - 1073 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - United States KW - Animals KW - National Institutes of Health (U.S.) KW - Disease Models, Animal KW - Adrenal Gland Neoplasms -- pathology KW - Pheochromocytoma -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68145084?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Animal+models+of+pheochromocytoma+including+NIH+initial+experience.&rft.au=Ohta%2C+Shoichiro%3BLai%2C+Edwin+W%3BTaniguchi%2C+Shun%27Ichiro%3BTischler%2C+Arthur+S%3BAlesci%2C+Salvatore%3BPacak%2C+Karel&rft.aulast=Ohta&rft.aufirst=Shoichiro&rft.date=2006-08-01&rft.volume=1073&rft.issue=&rft.spage=300&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Gene expression profiling of rat pheochromocytoma. AN - 68142054; 17102098 AB - Sporadic and syndrome-associated human pheochromocytomas exhibit a spectrum of common and distinctive phenotypic markers. Animal models may contribute to understanding of common denominators leading to development and progression of pheochromocytoma, and to mechanisms that underlie distinctive phenotypes. Rat pheochromocytomas are common, in contrast to their human counterparts, and their frequency is increased by a variety of genotoxic or nongenotoxic agents. Toxicological studies of rats are therefore a potentially rich source of information on pheochromocytoma biology. To compare the molecular profiles of rat and human pheochromocytomas and to identify pathways potentially involved in pathogenesis of rat pheochromocytomas, we conducted a gene expression profiling study comparing 31 pheochromocytomas obtained from the National Toxicology Program to normal adult rat adrenal medulla. The microarray chips were generated from 31,769-oligomer set representing over 27,200 unique Mouse Ensembl genes. The analysis showed over 1,900 genes that were up- or downregulated in the tumors. More than half of the former are involved in protein synthesis and signal transduction, including oncogenes of the RAS family and several heat shock proteins and chaperones. Downregulated genes included receptors and tumor-suppressor genes, including NF2 and Dmbt1. Specific genes related to neuroendocrine function were either upregulated or downregulated in subsets of tumors. Cross-comparison with a human pheochromocytoma database showed greater than 60% correlation. Results of this study reveal both generic and specific parallels between rat and human pheochromocytomas. JF - Annals of the New York Academy of Sciences AU - Elkahloun, Abdel G AU - Powers, James F AU - Nyska, Abraham AU - Eisenhofer, Graeme AU - Tischler, Arthur S AD - Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bldg. 50, 50 South Drive, Bethesda, MD 20892, USA. abdel@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 290 EP - 299 VL - 1073 SN - 0077-8923, 0077-8923 KW - Index Medicus KW - Rats KW - Animals KW - Humans KW - Adrenal Gland Neoplasms -- genetics KW - Gene Expression Profiling KW - Pheochromocytoma -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68142054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Annals+of+the+New+York+Academy+of+Sciences&rft.atitle=Gene+expression+profiling+of+rat+pheochromocytoma.&rft.au=Elkahloun%2C+Abdel+G%3BPowers%2C+James+F%3BNyska%2C+Abraham%3BEisenhofer%2C+Graeme%3BTischler%2C+Arthur+S&rft.aulast=Elkahloun&rft.aufirst=Abdel&rft.date=2006-08-01&rft.volume=1073&rft.issue=&rft.spage=290&rft.isbn=&rft.btitle=&rft.title=Annals+of+the+New+York+Academy+of+Sciences&rft.issn=00778923&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-11-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Understanding risk behaviours: how the sociology of deviance may contribute? The case of drug-taking. AN - 68065508; 16533551 AB - This paper argues that the sociology of deviance can be used to improve our understanding of some difficulties and unintended effects of health-promotion interventions designed to change risk behaviours, especially drug-taking. Firstly, many people engaged in 'risk behaviours' tend to deny the 'risky' label just as delinquents neutralise the 'deviant' label, and preventive information itself may be used by individuals in shaping risk denial. Secondly, deliberate risk-taking may be an 'innovative deviance',which is related to difficulties of conforming to the dominant 'risk culture'. Health promotion is likely to be quite ineffective if it remains wedded to the dominant risk culture and de facto contributes to the spread of it. JF - Social science & medicine (1982) AU - Peretti-Watel, Patrick AU - Moatti, Jean-Paul AD - Health and Medical Research National Institute, French National Cancer Institute, and Regional Centre for Disease Control of South-Eastern France, Marseilles. peretti@marseille.inserm.fr Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 675 EP - 679 VL - 63 IS - 3 SN - 0277-9536, 0277-9536 KW - Index Medicus KW - France KW - Denial (Psychology) KW - Humans KW - Models, Theoretical KW - Health Promotion KW - Sociology KW - Risk-Taking KW - Substance-Related Disorders -- ethnology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68065508?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Social+science+%26+medicine+%281982%29&rft.atitle=Understanding+risk+behaviours%3A+how+the+sociology+of+deviance+may+contribute%3F+The+case+of+drug-taking.&rft.au=Peretti-Watel%2C+Patrick%3BMoatti%2C+Jean-Paul&rft.aulast=Peretti-Watel&rft.aufirst=Patrick&rft.date=2006-08-01&rft.volume=63&rft.issue=3&rft.spage=675&rft.isbn=&rft.btitle=&rft.title=Social+science+%26+medicine+%281982%29&rft.issn=02779536&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-05 N1 - Date created - 2006-06-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intra-Rater and Inter-Rater Reliability of the 10-Point Manual Muscle Test (MMT) of Strength in Children with Juvenile Idiopathic Inflammatory Myopathies (JIIM) AN - 57291533; 200922517 AB - Objective. Children with juvenile idiopathic inflammatory myopathies (JIIM) present with muscle inflammation and decreased strength that may affect their functional abilities. The purpose of this study was to determine the intra-rater and inter-rater reliability of the 0 to10-point manual muscle testing method for children with JIIM. Methods. For the intra-rater and inter-rater reliability studies, 10 and 9 children with JIIM participated, respectively. For intra-rater reliability, one pediatric therapist completed two assessments in one day with a one-hour break. For inter-rater reliability, four therapists assessed the same child within a single morning. Results. Spearman correlations for intra-rater reliability ranged from 0.70 to 1.00. Kendall's W coefficient for inter-rater reliability of groups of muscles (total, proximal, distal, and peripheral) ranged from 0.51 to 0.76. Conclusions. The total, proximal, and peripheral Manual Muscle Test (MMT) score, using the 0-10 point scale, has acceptable reliability in JIIM patients. Adapted from the source document. JF - Physical and Occupational Therapy in Pediatrics AU - Jain, Minal AU - Smith, Michaele AU - Cintas, Holly AU - Koziol, Deloris AU - Wesley, Robert AU - Harris-Love, Michael AU - Lovell, Dan AU - Rider, Lisa G AU - Hicks, Jeanne AD - Rehabilitation Medicine Department, National Institutes of Health Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 5 EP - 17 PB - Informa Healthcare, New York NY VL - 26 IS - 3 SN - 0194-2638, 0194-2638 KW - Assessment KW - Idiopathic KW - Paediatrics KW - Reliability KW - Muscles KW - Children KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57291533?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Physical+and+Occupational+Therapy+in+Pediatrics&rft.atitle=Intra-Rater+and+Inter-Rater+Reliability+of+the+10-Point+Manual+Muscle+Test+%28MMT%29+of+Strength+in+Children+with+Juvenile+Idiopathic+Inflammatory+Myopathies+%28JIIM%29&rft.au=Jain%2C+Minal%3BSmith%2C+Michaele%3BCintas%2C+Holly%3BKoziol%2C+Deloris%3BWesley%2C+Robert%3BHarris-Love%2C+Michael%3BLovell%2C+Dan%3BRider%2C+Lisa+G%3BHicks%2C+Jeanne&rft.aulast=Jain&rft.aufirst=Minal&rft.date=2006-08-01&rft.volume=26&rft.issue=3&rft.spage=5&rft.isbn=&rft.btitle=&rft.title=Physical+and+Occupational+Therapy+in+Pediatrics&rft.issn=01942638&rft_id=info:doi/10.1300%2FJ006v26n03_02 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2009-08-31 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Reliability; Children; Muscles; Idiopathic; Assessment; Paediatrics DO - http://dx.doi.org/10.1300/J006v26n03_02 ER - TY - JOUR T1 - The Coverage Priorities of Disabled Adult Medi-Cal Beneficiaries AN - 57103374; 200705016 AB - Medi-Cal, like other Medicaid programs around the U.S., has been pressed to cut its budget. We report the results of a project using the CHAT (Choosing Healthplans All Together) exercise, designed to ascertain the priorities of disabled adult Medi-Cal beneficiaries to inform any decisions regarding Medi-Cal benefits. Participants voiced greatest interest in maintaining a wide spectrum of benefits & access to a large pool of providers & were most willing to restrict pharmacy benefits. The resulting findings may be of value to legislators drafting Medicaid proposals that revise benefits for this vulnerable population. Tables, Figures, Appendixes. Adapted from the source document. JF - Journal of Health Care for the Poor and Underserved AU - Danis, Marion AU - Ginsburg, Marjorie AU - Goold, Susan Dorr AD - Dept Clinical Bioethics, National Instits Health, Bethesda, MD mdanis@nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 592 EP - 609 PB - John Hopkins University Press, Baltimore MD VL - 17 IS - 3 SN - 1049-2089, 1049-2089 KW - Medicaid, insurance benefits, cost and benefits, social policy, health policy, consumer preference KW - Client satisfaction KW - Coverage KW - Disabled people KW - Priorities KW - Medicaid KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57103374?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.atitle=The+Coverage+Priorities+of+Disabled+Adult+Medi-Cal+Beneficiaries&rft.au=Danis%2C+Marion%3BGinsburg%2C+Marjorie%3BGoold%2C+Susan+Dorr&rft.aulast=Danis&rft.aufirst=Marion&rft.date=2006-08-01&rft.volume=17&rft.issue=3&rft.spage=592&rft.isbn=&rft.btitle=&rft.title=Journal+of+Health+Care+for+the+Poor+and+Underserved&rft.issn=10492089&rft_id=info:doi/ LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2007-05-30 N1 - Last updated - 2016-09-27 N1 - CODEN - JHCUEK N1 - SubjectsTermNotLitGenreText - Medicaid; Client satisfaction; Coverage; Priorities; Disabled people ER - TY - JOUR T1 - Introduction to Special Section on the National Institute of Health State of the Science Report on Violence Prevention AN - 57072728; 200619201 AB - This introduction presents the National Institutes of Health (NIH) conference on Preventing Violence and Related Health-Risking Social Behaviors in Adolescents. The article details the NIH effort to examine and assess the current state of knowledge regarding youth violence and related health-risking social behavior and identify directions for future research. JF - Journal of Abnormal Child Psychology AU - Tuma, Farris AU - Loeber, Rolf AU - Lochman, John E AD - National Instit Mental Health, Bethesda MD ftuma@nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 451 EP - 456 PB - Springer, Dordrecht The Netherlands VL - 34 IS - 4 SN - 0091-0627, 0091-0627 KW - Prevention KW - Social behaviour KW - Violence KW - Preventive programmes KW - Adolescents KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57072728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Introduction+to+Special+Section+on+the+National+Institute+of+Health+State+of+the+Science+Report+on+Violence+Prevention&rft.au=Tuma%2C+Farris%3BLoeber%2C+Rolf%3BLochman%2C+John+E&rft.aulast=Tuma&rft.aufirst=Farris&rft.date=2006-08-01&rft.volume=34&rft.issue=4&rft.spage=451&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1007%2Fx10802-006-9039-6 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - JAPCAC N1 - SubjectsTermNotLitGenreText - Adolescents; Violence; Social behaviour; Prevention; Preventive programmes DO - http://dx.doi.org/10.1007/x10802-006-9039-6 ER - TY - JOUR T1 - Health-Risking Social Behaviors: Moving Forward AN - 57071341; 200618828 AB - The National Institute of Mental Health (NIMH) & the National Institute on Drug Abuse (NIDA) have a long history of supporting investigator-initiated research & research training to enhance the scientific understanding of & effective interventions for a range of problems associated with youth violence. New technologies are emerging & basic research has promise for increasing our understanding of how biological factors operate in conjunction with other factors to contribute to violent behavior, psychopathology, & drug abuse. This article describes emerging areas & directions for research in this important area of public health. References. Adapted from the source document. JF - Journal of Abnormal Child Psychology AU - Price, LeShawndra N AU - Reider, Eve E AU - Robertson, Elizabeth B AD - Dept Health & Human Services, National Instit Mental Health, Bethesda, MD lprice@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 489 EP - 494 PB - Springer, Dordrecht The Netherlands VL - 34 IS - 4 SN - 0091-0627, 0091-0627 KW - Youth violence, Drug abuse, Antisocial behavior, Child conduct problems, Conduct disorder, Externalizing behaviors KW - Risk factors KW - Social behaviour KW - Antisocial behaviour KW - Violence KW - Substance abuse KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57071341?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Child+Psychology&rft.atitle=Health-Risking+Social+Behaviors%3A+Moving+Forward&rft.au=Price%2C+LeShawndra+N%3BReider%2C+Eve+E%3BRobertson%2C+Elizabeth+B&rft.aulast=Price&rft.aufirst=LeShawndra&rft.date=2006-08-01&rft.volume=34&rft.issue=4&rft.spage=489&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Child+Psychology&rft.issn=00910627&rft_id=info:doi/10.1007%2Fx10802-006-9041-z LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - JAPCAC N1 - SubjectsTermNotLitGenreText - Violence; Substance abuse; Social behaviour; Risk factors; Antisocial behaviour DO - http://dx.doi.org/10.1007/x10802-006-9041-z ER - TY - JOUR T1 - Applying Transdisciplinary Research Strategies to Understanding and Eliminating Health Disparities AN - 57068067; 200617252 AB - This overview for the special issue of Health Education & Behavior on "Health Disparities & Social Inequities" briefly outlines the transdisciplinary (TD) approach to research & examines the scope of TD science. The need to embrace basic science as well as several domains of applied research is discussed along the TD "pipeline" from discovery to development to delivery to policy. The overview concludes with selected examples of the emerging TD science of disparities. One central challenge for a TD approach is the need to strengthen what is being called "the science of dissemination" along with improving the "dissemination of evidence-based science.". Figures, References. [Reprinted by permission of Sage Publications Inc., copyright 2006, Society for Public Health Education.] JF - Health Education & Behavior AU - Abrams, David B AD - OBSSR, National Instit Health, Bethesda, MD Abramsd@od.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 515 EP - 531 PB - Sage Publications, Thousand Oaks CA VL - 33 IS - 4 SN - 1090-1981, 1090-1981 KW - transdisciplinary KW - disparities KW - health KW - Health education KW - Disparity KW - Health KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57068067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Health+Education+%26+Behavior&rft.atitle=Applying+Transdisciplinary+Research+Strategies+to+Understanding+and+Eliminating+Health+Disparities&rft.au=Abrams%2C+David+B&rft.aulast=Abrams&rft.aufirst=David&rft.date=2006-08-01&rft.volume=33&rft.issue=4&rft.spage=515&rft.isbn=&rft.btitle=&rft.title=Health+Education+%26+Behavior&rft.issn=10901981&rft_id=info:doi/10.1177%2F1090198106287732 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-29 N1 - Last updated - 2016-09-27 N1 - CODEN - HEDBFS N1 - SubjectsTermNotLitGenreText - Health; Disparity; Health education DO - http://dx.doi.org/10.1177/1090198106287732 ER - TY - JOUR T1 - Emotion at the Expense of Cognition: Psychopathic Individuals Outperform Controls on an Operant Response Task AN - 57056006; 200616705 AB - The impact of emotional stimuli on a simple motor response task in individuals with psychopathy & comparison individuals was investigated. Psychopathy was assessed using the Psychopathy Checklist Revised (Hare, 1991). Participants were presented with the Emotional Interrupt Task, in which they responded with left & right button presses to shapes that were temporally bracketed by positive, negative, & neutral visual images taken from the International Affective Picture System. The comparison group showed increased response latencies if the shape was temporally bracketed by either a positive or negative emotional stimulus relative to a neutral stimulus. Individuals with psychopathy did not show this modulation of reaction time for either positive or negative emotional stimuli. Results are discussed with reference to current models regarding the modulation of attention by emotion & the emotional impairment seen in individuals with psychopathy. Tables, Figures, References. [Copyright 2006 American Psychological Association.] JF - Journal of Abnormal Psychology AU - Mitchell, Derek G V AU - Richell, Rebecca A AU - Leonard, Alan AU - Blair, R James R AD - Mood & Anxiety Disorders Program, National Instit Mental Health, Bethesda, MD mitchelld@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 559 EP - 566 PB - American Psychological Association, Washington DC VL - 115 IS - 3 SN - 0021-843X, 0021-843X KW - psychopathy, antisocial behavior, amygdala, attention KW - Emotions KW - Response selection KW - Psychopathy KW - Antisocial Behaviour KW - Distraction KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57056006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Emotion+at+the+Expense+of+Cognition%3A+Psychopathic+Individuals+Outperform+Controls+on+an+Operant+Response+Task&rft.au=Mitchell%2C+Derek+G+V%3BRichell%2C+Rebecca+A%3BLeonard%2C+Alan%3BBlair%2C+R+James+R&rft.aulast=Mitchell&rft.aufirst=Derek+G&rft.date=2006-08-01&rft.volume=115&rft.issue=3&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2F0021-843X.115.3.559 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Psychopathy; Antisocial Behaviour; Response selection; Emotions; Distraction DO - http://dx.doi.org/10.1037/0021-843X.115.3.559 ER - TY - JOUR T1 - Mood Switch in Bipolar Depression: Comparison of Adjunctive Venlafaxine, Bupropion and Sertraline AN - 57053095; 200616838 AB - Declaration of interest: None. Background: Few studies have examined the relative risks of switching into hypomania or mania associated with second-generation antidepressant drugs in bipolar depression. Aims: To examine the relative acute effects of bupropion, sertraline & venlafaxine as adjuncts to mood stabilisers. Method: In a 10-week trial, participants receiving out-patient treatment for bipolar disorder (stratified for rapid cycling) were randomly treated with a flexible dose of one of the antidepressants, or their respective matching placebos, as adjuncts to mood stabilisers. Results: A total of 174 adults with bipolar disorder I, II or not otherwise specified, currently in the depressed phase, were included. All three antidepressants were associated with a similar range of acute response (49-53%) & remission (34-41%). There was a significantly increased risk of switches into hypomania or mania in participants treated with venlafaxine compared with bupropion or sertraline. Conclusions: More caution appears indicated in the use of venlafaxine rather than bupropion or sertraline in the adjunctive treatment of bipolar depression, especially if there is a prior history of rapid cycling. Tables, Figures, References. Adapted from the source document. JF - The British Journal of Psychiatry AU - Post, R M AU - Altshuler, L L AU - Leverich, G S AU - Frye, M A AU - Nolen, W A AU - Kupka, R W AU - Suppes, T AU - McElroy, S AU - Keck, P E AU - Denicoff, K D AU - Grunze, H AU - Kitchen, C M R AU - Mintz, J AD - Dept Health & Human Services, National Instit Mental Health, Bethesday, MD post@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 124 EP - 131 PB - Royal College of Psychiatrists, London UK VL - 189 SN - 0007-1250, 0007-1250 KW - Mood changes KW - Depression KW - Bipolar affective disorder KW - Antidepressant drugs KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57053095?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+British+Journal+of+Psychiatry&rft.atitle=Mood+Switch+in+Bipolar+Depression%3A+Comparison+of+Adjunctive+Venlafaxine%2C+Bupropion+and+Sertraline&rft.au=Post%2C+R+M%3BAltshuler%2C+L+L%3BLeverich%2C+G+S%3BFrye%2C+M+A%3BNolen%2C+W+A%3BKupka%2C+R+W%3BSuppes%2C+T%3BMcElroy%2C+S%3BKeck%2C+P+E%3BDenicoff%2C+K+D%3BGrunze%2C+H%3BKitchen%2C+C+M+R%3BMintz%2C+J&rft.aulast=Post&rft.aufirst=R&rft.date=2006-08-01&rft.volume=189&rft.issue=&rft.spage=124&rft.isbn=&rft.btitle=&rft.title=The+British+Journal+of+Psychiatry&rft.issn=00071250&rft_id=info:doi/10.1192%2Fbjp.bp.105.013045 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - BJPYAJ N1 - SubjectsTermNotLitGenreText - Bipolar affective disorder; Depression; Antidepressant drugs; Mood changes DO - http://dx.doi.org/10.1192/bjp.bp.105.013045 ER - TY - JOUR T1 - Impaired Reversal but Intact Acquisition: Probabilistic Response Reversal Deficits in Adult Individuals with Psychopathy AN - 57045926; 200616065 AB - The performance of adult psychopathic individuals on a novel response reversal task involving 2 reward-punishment contingencies (100-0 & 80-20) was investigated. In line with predictions, adults with psychopathy presented with impairment on the response reversal component but not on the acquisition component of this task. This selective impairment for response reversal was seen for both reward-punishment contingencies & was related to the tendency of individuals with psychopathy to be less likely to stay with a rewarded correct response to a stimulus on the subsequent presentation of that stimulus. Results are discussed with reference to current models of the development of psychopathy. Tables, Figures, References. [Copyright 2006 American Psychological Association.] JF - Journal of Abnormal Psychology AU - Budhani, Salima AU - Richell, Rebecca A AU - Blair, R James R AD - c/o Blair -- Unit Affective Cognitive Neuroscience, Mood & Anxiety Disorders Program, National Instit Mental Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 552 EP - 558 PB - American Psychological Association, Washington DC VL - 115 IS - 3 SN - 0021-843X, 0021-843X KW - psychopathy, response reversal, integrated emotion systems model, fear dysfunction position KW - Response selection KW - Psychopathy KW - Impairment KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57045926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Abnormal+Psychology&rft.atitle=Impaired+Reversal+but+Intact+Acquisition%3A+Probabilistic+Response+Reversal+Deficits+in+Adult+Individuals+with+Psychopathy&rft.au=Budhani%2C+Salima%3BRichell%2C+Rebecca+A%3BBlair%2C+R+James+R&rft.aulast=Budhani&rft.aufirst=Salima&rft.date=2006-08-01&rft.volume=115&rft.issue=3&rft.spage=552&rft.isbn=&rft.btitle=&rft.title=Journal+of+Abnormal+Psychology&rft.issn=0021843X&rft_id=info:doi/10.1037%2F0021-843X.115.3.552 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-11-03 N1 - Last updated - 2016-09-27 N1 - CODEN - JABCAA N1 - SubjectsTermNotLitGenreText - Psychopathy; Response selection; Impairment DO - http://dx.doi.org/10.1037/0021-843X.115.3.552 ER - TY - JOUR T1 - Personality Plasticity after Age 30 AN - 57039200; 200615661 AB - Rank-order consistency of personality traits increases from childhood to age 30. After that, different summaries of the literature predict a plateau at age 30, or at age 50, or a curvilinear peak in consistency at age 50. These predictions were evaluated at group and individual levels using longitudinal data from the Guilford-Zimmerman Temperament Survey and the Revised NEO Personality Inventory for periods of up to 42 years. Consistency declined toward a nonzero asymptote with increasing time interval. Although some scales showed increasing stability after age 30, the rank-order consistencies of the major dimensions and most facets of the Five-Factor Model were unrelated to age. Ipsative stability, assessed with the California Adult Q-Set, also was unrelated to age. These data strengthen claims of predominant personality stability after age 30. 4 Tables, 1 Figure, 45 References. [Reprinted by permission of Sage Publications Inc., copyright 2006 the Society for Personality and Social Psychology, Inc.] JF - Personality and Social Psychology Bulletin AU - Terracciano, Antonio AU - Costa, Paul T, Jr AU - McCrae, Robert R AD - Gerontology Research Center, Baltimore, MD terraccianoa@grc.nia.nih.gov Y1 - 2006/08// PY - 2006 DA - August 2006 SP - 999 EP - 1009 PB - Sage Publications, Thousand Oaks CA VL - 32 IS - 8 SN - 0146-1672, 0146-1672 KW - Five-Factor Model KW - personality development KW - long-term stability KW - individual differences KW - life span KW - older adults KW - Social constructionism KW - Individual differences KW - Five factor model KW - Life span KW - Personality development KW - Stability KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57039200?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Social+Psychology+Bulletin&rft.atitle=Personality+Plasticity+after+Age+30&rft.au=Terracciano%2C+Antonio%3BCosta%2C+Paul+T%2C+Jr%3BMcCrae%2C+Robert+R&rft.aulast=Terracciano&rft.aufirst=Antonio&rft.date=2006-08-01&rft.volume=32&rft.issue=8&rft.spage=999&rft.isbn=&rft.btitle=&rft.title=Personality+and+Social+Psychology+Bulletin&rft.issn=01461672&rft_id=info:doi/10.1177%2F0146167206288599 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-10-02 N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Social constructionism; Five factor model; Life span; Stability; Individual differences; Personality development DO - http://dx.doi.org/10.1177/0146167206288599 ER - TY - JOUR T1 - Genetic structure in contemporary South Tyrolean isolated populations revealed by analysis of y-chromosome, mtDNA, and alu polymorphisms AN - 36610121; 3396358 AB - Most of the inhabitants of South Tyrol in the eastern Italian Alps can be considered isolated populations because of their physical separation by mountain barriers and their sociocultural heritage. We analyzed the genetic structure of South Tyrolean populations using three types of genetic markers: Y-chromosome, mitochondrial DNA (mtDNA), and autosomal Alu markers. Using random samples taken from the populations of Val Venosta, Val Pusteria, Val Isarco, Val Badia, and Val Gardena, we calculated genetic diversity within and among the populations. Microsatellite diversity and unique event polymorphism diversity (on the Y chromosome) were substantially lower in the Ladin-speaking population of Val Badia compared to the neighboring German-speaking populations. In contrast, the genetic diversity of mtDNA haplotypes was lowest for the upper Val Venosta and Val Pusteria. These data suggest a low effective population size, or little admixture, for the gene pool of the Ladin-speaking population from Val Badia. Interestingly, this is more pronounced for Ladin males than for Ladin females. For the pattern of genetic Alu variation, both Ladin samples (Val Gardena and Val Badia) are among the samples with the lowest diversity. An admixture analysis of one German-speaking valley (Val Venosta) indicates a relatively high genetic contribution of Ladin origin. The reduced genetic diversity and a high genetic differentiation in the Rhaetoroman- and German-speaking South Tyrolean populations may constitute an important basis for future medical genetic research and gene mapping studies in South Tyrol. Reprinted with the permission of Wayne University Press JF - Human biology AU - Pichler, Irene AU - Mueller, Jakob C AU - Stefanov, Stefan A AU - Grandi, Alessandro De AU - Volpato, Claudia Beu AU - Pinggera, Gerd K AU - Mayr, Agnes AU - Ogriseg, Martin AU - Ploner, Franz AU - Meitinger, Thomas AU - Pramstaller, Peter P AD - European Academy of Bolzano ; Technischen Universität München ; National Cancer Institute, Maryland ; Hospital of Brunico, Brunico-Bruneck, Italy ; Hospital of Bressanone, Bressanone-Brixen, Italy ; Hospital of Vipiteno, Vipiteno-Sterzing, Italy ; Universität zu Lübeck Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 441 EP - 464 VL - 78 IS - 4 SN - 1534-6617, 1534-6617 KW - Anthropology KW - Polymorphism KW - South Tyrol KW - Biological anthropology KW - Human biology KW - Genetics KW - Chromosomes KW - Current research KW - Diversification KW - Medical research KW - DNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36610121?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Human+biology&rft.atitle=Genetic+structure+in+contemporary+South+Tyrolean+isolated+populations+revealed+by+analysis+of+y-chromosome%2C+mtDNA%2C+and+alu+polymorphisms&rft.au=Pichler%2C+Irene%3BMueller%2C+Jakob+C%3BStefanov%2C+Stefan+A%3BGrandi%2C+Alessandro+De%3BVolpato%2C+Claudia+Beu%3BPinggera%2C+Gerd+K%3BMayr%2C+Agnes%3BOgriseg%2C+Martin%3BPloner%2C+Franz%3BMeitinger%2C+Thomas%3BPramstaller%2C+Peter+P&rft.aulast=Pichler&rft.aufirst=Irene&rft.date=2006-08-01&rft.volume=78&rft.issue=4&rft.spage=441&rft.isbn=&rft.btitle=&rft.title=Human+biology&rft.issn=15346617&rft_id=info:doi/ LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 5460 1615 8573 11325; 2257 5455 1678; 3254 5460 1615 8573 11325; 3649; 7886 10902; 6072 1615 8573 11325; 3225 10902; 1608 1077 ER - TY - JOUR T1 - Physiologically-based pharmacokinetic modeling of benzene in humans: a Bayesian approach AN - 36573091; 3372403 AB - Benzene is myclotoxic and leukemogenic in humans exposed at high doses (> 1 ppm, more definitely above 10 ppm) for extended periods. However, leukemia risks at lower exposures are uncertain. Benzene occurs widely in the work environment and also indoor air, but mostly below 1 ppm, so assessing the leukemia risks at these low concentrations is important. Here, we describe a human physiologically-based pharmacokinetic (PBPK) model that quantifies tissue doses of benzene and its key metabolites, benzene oxide, phenol, and hydroquinone after inhalation and oral exposures. The model was integrated into a statistical framework that acknowledges sources of variation due to inherent intra- and interindividual variation, measurement error, and other data collection issues. A primary contribution of this work is the estimation of population distributions of key PBPK model parameters. We hypothesized that observed interindividual variability in the dosimetry of benzene and its metabolites resulted primarily from known or estimated variability in key metabolic parameters and that a statistical PBPK model that explicitly included variability in only those metabolic parameters would sufficiently describe the observed variability. We then identified parameter distributions for the PBPK model to characterize observed variability through the use of Markov chain Monte Carlo analysis applied to two data sets. The identified parameter distributions described most of the observed variability, but variability in physiological parameters such as organ weights may also be helpful to faithfully predict the observed human-population variability in benzene dosimetry. Reprinted by permission of Blackwell Publishers JF - Risk analysis AU - Yokley, Karen AU - Tran, Hien T AU - Pekari, Kaija AU - Rappaport, Stephen AU - Riihimaki, Vesa AU - Rothman, Nat AU - Waidyanatha, Suramya AU - Schlosser, Paul M AD - North Carolina State University ; Finnish Institute of Occupational Health ; University of North Carolina ; National Cancer Institute ; CIIT Centers for Health Research Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 925 EP - 944 VL - 26 IS - 4 SN - 0272-4332, 0272-4332 KW - Sociology KW - Medical research KW - Statistical analysis KW - Diseases KW - Bayesian method KW - Modelling UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/36573091?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aibss&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Risk+analysis&rft.atitle=Physiologically-based+pharmacokinetic+modeling+of+benzene+in+humans%3A+a+Bayesian+approach&rft.au=Yokley%2C+Karen%3BTran%2C+Hien+T%3BPekari%2C+Kaija%3BRappaport%2C+Stephen%3BRiihimaki%2C+Vesa%3BRothman%2C+Nat%3BWaidyanatha%2C+Suramya%3BSchlosser%2C+Paul+M&rft.aulast=Yokley&rft.aufirst=Karen&rft.date=2006-08-01&rft.volume=26&rft.issue=4&rft.spage=925&rft.isbn=&rft.btitle=&rft.title=Risk+analysis&rft.issn=02724332&rft_id=info:doi/10.1111%2Fj.1539-6924.2006.00789.x LA - English DB - International Bibliography of the Social Sciences (IBSS) N1 - Date revised - 2013-06-12 N1 - Last updated - 2013-09-16 N1 - SubjectsTermNotLitGenreText - 7886 10902; 3617 6220; 8162 8163; 1512 3865 4025; 12224 971 DO - http://dx.doi.org/10.1111/j.1539-6924.2006.00789.x ER - TY - JOUR T1 - Strategies for optimizing combinations of molecularly targeted anticancer agents AN - 21311398; 11938313 AB - The rapid emergence of hundreds of new agents that modulate an ever-growing list of cancer-specific molecular targets offers tremendous hope for cancer patients. However, evaluating targeted agents individually, in combination with standard treatments, and in combination with other targeted agents presents significant development challenges. Because the number of possible drug combinations is essentially limitless, a strategy for determining the most promising combinations and prioritizing their evaluation is crucial. Here, we consider the crucial elements of a development strategy for targeted-agent combinations. Issues that pose challenges to the rational preclinical and clinical evaluation of such combinations will be described, and possible approaches to overcoming these challenges will be discussed. JF - Nature Reviews: Drug Discovery AU - Dancey, Janet E AU - Chen, Helen X AD - Investigational Drug Branch, Cancer Therapy Evaluation Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, 6130 Executive Boulevard EPN 7131, Rockville, Maryland 20852, USA. Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 649 EP - 659 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 5 IS - 8 SN - 1474-1776, 1474-1776 KW - Biotechnology and Bioengineering Abstracts KW - Reviews KW - Development KW - Antitumor agents KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21311398?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Drug+Discovery&rft.atitle=Strategies+for+optimizing+combinations+of+molecularly+targeted+anticancer+agents&rft.au=Dancey%2C+Janet+E%3BChen%2C+Helen+X&rft.aulast=Dancey&rft.aufirst=Janet&rft.date=2006-08-01&rft.volume=5&rft.issue=8&rft.spage=649&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Drug+Discovery&rft.issn=14741776&rft_id=info:doi/10.1038%2Fnrd2089 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Reviews; Development; Antitumor agents DO - http://dx.doi.org/10.1038/nrd2089 ER - TY - JOUR T1 - Combining Treatment Selection and Definitive Testing AN - 21093970; 11132881 AB - This is a discussion of the following two papers appearing in this special issue on adaptive designs: An adaptive hierarchical test procedure for selecting safe and efficient treatments by Franz Konig, Peter Bauer and Werner Brannath, and An adaptive two-stage design with treatment selection using the conditional error function approach by Jixian Wang. JF - Biometrical Journal AU - Proschan, Michael A AU - Hunsberger, Sally A AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, 6700A Rockledge Drive, Bethesda, MD, USA, proscham@niaid.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 690 EP - 692 PB - Wiley-Blackwell, 111 River Street Hoboken NJ 07030-5774 USA VL - 48 IS - 4 SN - 0323-3847, 0323-3847 KW - Biotechnology and Bioengineering Abstracts KW - Statistics KW - Biometrics KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21093970?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biometrical+Journal&rft.atitle=Combining+Treatment+Selection+and+Definitive+Testing&rft.au=Proschan%2C+Michael+A%3BHunsberger%2C+Sally+A&rft.aulast=Proschan&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=48&rft.issue=4&rft.spage=690&rft.isbn=&rft.btitle=&rft.title=Biometrical+Journal&rft.issn=03233847&rft_id=info:doi/10.1002%2Fbimj.200610247 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-11-01 N1 - Last updated - 2011-12-14 N1 - SubjectsTermNotLitGenreText - Biometrics; Statistics DO - http://dx.doi.org/10.1002/bimj.200610247 ER - TY - JOUR T1 - Maltodextrin Utilization Plays a Key Role in the Ability of Group A Streptococcus To Colonize the Oropharynx AN - 20987467; 7128398 AB - Analysis of multiple group A Streptococcus (GAS) genomes shows that genes encoding proteins involved in carbohydrate utilization comprise some 15% of the core GAS genome. Yet there is a limited understanding of how carbohydrate utilization contributes to GAS pathogenesis. Previous genome-wide GAS studies led us to a focused investigation of MalE, a putative maltodextrin-binding protein. Analysis of 28 strains of 22 distinct M protein serotypes showed that MalE is highly conserved among diverse GAS strains. malE transcript levels were significantly increased during growth in human saliva compared to growth in a chemically defined glucose-containing medium or a nutrient-rich medium. MalE was accessible to antibody binding, indicating that it is expressed on the GAS cell surface. Moreover, growth in human saliva appeared to increase MalE surface expression compared to growth in a nutrient-rich medium. Analysis of a Delta malE isogenic mutant strain revealed decreased growth in human saliva compared to wild-type GAS. Radiolabeled carbohydrate binding assays showed that MalE was required for the binding of maltose but not glucose. The Delta malE isogenic mutant strain colonized a lower percentage of GAS-challenged mice compared to wild-type and genetically complemented strains. Furthermore, decreased numbers of CFU were recovered from mice infected with the Delta malE strain compared to those infected with wild-type GAS. These data demonstrate that maltodextrin acquisition is likely to be a key factor in the ability of GAS to successfully infect the oropharynx. Further investigation into carbohydrate transport and metabolism pathways may yield novel insights into GAS pathogenesis. JF - Infection and Immunity AU - Shelburne, Samuel AIII AU - Sumby, Paul AU - Sitkiewicz, Izabela AU - Okorafor, Nnaja AU - Granville, Chanel AU - Patel, Payal AU - Voyich, Jovanka AU - Hull, Richard AU - DeLeo, Frank R AU - Musser, James M AD - Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030. Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute, Houston, Texas 77030. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 4605 EP - 4614 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 8 SN - 0019-9567, 0019-9567 KW - streptococci KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Streptococcus KW - Genomes KW - Cell surface KW - Coding KW - Carbohydrate metabolism KW - Serotypes KW - Oropharynx KW - Data processing KW - double prime M protein KW - Glucose KW - Transcription KW - maltodextrin KW - Antibodies KW - Colony-forming cells KW - Saliva KW - Carbohydrates KW - Maltose KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20987467?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Maltodextrin+Utilization+Plays+a+Key+Role+in+the+Ability+of+Group+A+Streptococcus+To+Colonize+the+Oropharynx&rft.au=Shelburne%2C+Samuel+AIII%3BSumby%2C+Paul%3BSitkiewicz%2C+Izabela%3BOkorafor%2C+Nnaja%3BGranville%2C+Chanel%3BPatel%2C+Payal%3BVoyich%2C+Jovanka%3BHull%2C+Richard%3BDeLeo%2C+Frank+R%3BMusser%2C+James+M&rft.aulast=Shelburne&rft.aufirst=Samuel&rft.date=2006-08-01&rft.volume=74&rft.issue=8&rft.spage=4605&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Genomes; Coding; Cell surface; Carbohydrate metabolism; Data processing; Oropharynx; Serotypes; double prime M protein; Glucose; Transcription; maltodextrin; Antibodies; Colony-forming cells; Carbohydrates; Saliva; Maltose; Streptococcus ER - TY - JOUR T1 - Water diffusion heterogeneity index in the human brain is insensitive to the orientation of applied magnetic field gradients AN - 20858038; 8368201 AB - The diffusion-weighted imaging (DWI) method was developed to study heterogeneous water diffusion in the human brain using magnetic resonance imaging (MRI). An advantage of this model is that it does not require an assumption about the shape of the intravoxel distribution of apparent diffusion rates, and it has a calculable relationship to this distribution. The -DWI technique is useful for detecting microstructural tissue changes associated with brain tumor invasion, and may be useful for directing therapy to invading tumor cells. In previous work, -DWI was performed with magnetic field gradients applied along a single direction in order to avoid artificially introducing a source of heterogeneity to the decay. However, it is known that restricted diffusion is anisotropic in the brain, and the -DWI method must take this into account to be complete. In this work the relationship between the applied magnetic field gradients and the fitted stretched-exponential model parameters was studied in the human brain. It was found the distributed diffusion coefficient (DDC) varies with the direction of applied gradients, while the heterogeneity index is relatively direction-insensitive. It is proposed that in clinical use, maps of can be created using diffusion-weighting gradients applied in a single direction that reflect the tissue heterogeneity. Magn Reson Med, 2006. JF - Magnetic Resonance in Medicine AU - Bennett, Kevin M AU - Hyde, James S AU - Schmainda, Kathleen M AD - Department of Biophysics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA, bennettkev@ninds.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 235 EP - 239 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts KW - Neuroimaging KW - Anisotropy KW - Magnetic resonance imaging KW - Maps KW - Tumor cells KW - Brain tumors KW - Magnetic fields KW - N.M.R. KW - Diffusion coefficient KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20858038?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=Water+diffusion+heterogeneity+index+in+the+human+brain+is+insensitive+to+the+orientation+of+applied+magnetic+field+gradients&rft.au=Bennett%2C+Kevin+M%3BHyde%2C+James+S%3BSchmainda%2C+Kathleen+M&rft.aulast=Bennett&rft.aufirst=Kevin&rft.date=2006-08-01&rft.volume=56&rft.issue=2&rft.spage=235&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20960 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Magnetic fields; Magnetic resonance imaging; Maps; Neuroimaging; N.M.R.; Diffusion coefficient; Tumor cells; Anisotropy; Brain tumors DO - http://dx.doi.org/10.1002/mrm.20960 ER - TY - JOUR T1 - MR assessment of changes of tumor in response to hyperbaric oxygen treatment AN - 20853775; 8368202 AB - Enhancement of image intensity, using the T1-weighted spoiled gradient-echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber designed and constructed to fit in an MRI resonator. The central portions of the tumor gave a positive enhancement, while the periphery showed signal reduction during both normobaric (NBO) and hyperbaric (HBO) oxygen challenges. In the contralateral normal leg, nearly 70% of the region showed a decrease in intensity, and the rest showed a positive enhancement. The positive signal enhancement was markedly greater under HBO compared to NBO. Calculated R1, R2, and M0 maps from multivariate fitting of images acquired by a multislice multiecho (MSME) sequence with variable TR before, during, and after HBO treatment confirm that the source of SPGR signal enhancement in the tumor is associated with shortening of T1. JF - Magnetic Resonance in Medicine AU - Matsumoto, Ken-ichiro AU - Bernardo, Marcelino AU - Subramanian, Sankaran AU - Choyke, Peter AU - Mitchell, James B AU - Krishna, Murali C AU - Lizak, Martin J AD - Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA, murali@helix.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 240 EP - 246 PB - John Wiley & Sons, Baffins Lane Chichester W. Sussex PO19 1UD UK, [mailto:customer@wiley.co.uk], [URL:http://www.wiley.com/] VL - 56 IS - 2 SN - 0740-3194, 0740-3194 KW - Biotechnology and Bioengineering Abstracts KW - Leg KW - Hyperbaric oxygen KW - Magnetic resonance imaging KW - N.M.R. KW - Tumors KW - Maps KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20853775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Magnetic+Resonance+in+Medicine&rft.atitle=MR+assessment+of+changes+of+tumor+in+response+to+hyperbaric+oxygen+treatment&rft.au=Matsumoto%2C+Ken-ichiro%3BBernardo%2C+Marcelino%3BSubramanian%2C+Sankaran%3BChoyke%2C+Peter%3BMitchell%2C+James+B%3BKrishna%2C+Murali+C%3BLizak%2C+Martin+J&rft.aulast=Matsumoto&rft.aufirst=Ken-ichiro&rft.date=2006-08-01&rft.volume=56&rft.issue=2&rft.spage=240&rft.isbn=&rft.btitle=&rft.title=Magnetic+Resonance+in+Medicine&rft.issn=07403194&rft_id=info:doi/10.1002%2Fmrm.20961 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Tumors; Magnetic resonance imaging; N.M.R.; Leg; Hyperbaric oxygen; Maps DO - http://dx.doi.org/10.1002/mrm.20961 ER - TY - JOUR T1 - The Final Word on HIV Infection in American Youth: Test! AN - 20765386; 8115429 AB - The views expressed in this article are those of the author and do not necessarily represent the views of the National Institute of Child Health and Human Development, The National Institutes of Health, or the Department of Health and Human Services. JF - Journal of Adolescent Health AU - Rogers, Audrey Smith AD - National Institutes of Health, Bethesda, Maryland Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 147 EP - 149 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 39 IS - 2 SN - 1054-139X, 1054-139X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts KW - Infectious diseases KW - Human immunodeficiency virus KW - Adolescence KW - Infection KW - Adolescents KW - V 22360:AIDS and HIV KW - H 11000:Diseases/Injuries/Trauma UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20765386?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Adolescent+Health&rft.atitle=The+Final+Word+on+HIV+Infection+in+American+Youth%3A+Test%21&rft.au=Rogers%2C+Audrey+Smith&rft.aulast=Rogers&rft.aufirst=Audrey&rft.date=2006-08-01&rft.volume=39&rft.issue=2&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Journal+of+Adolescent+Health&rft.issn=1054139X&rft_id=info:doi/10.1016%2Fj.jadohealth.2006.05.018 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Adolescence; Infection; Infectious diseases; Adolescents; Human immunodeficiency virus DO - http://dx.doi.org/10.1016/j.jadohealth.2006.05.018 ER - TY - JOUR T1 - CT and MRI of Hepatic Abscess in Patients with Chronic Granulomatous Disease AN - 20679066; 10065445 AB - OBJECTIVE. We describe the spectrum of radiologic appearances of hepatic abscesses in patients with chronic granulomatous disease (CGD), a hereditary immunodeficiency presenting in childhood that occurs at a rate of 1 in 200,000-250,000 live births and predisposes patients to infection with catalase-positive organisms. CONCLUSION. Hepatic abscesses in patients with CGD show an atypical radiologic appearance compared with sporadic hepatic abscesses, and they are characterized by homogeneous enhancement and multiseptal enhancement. In the appropriate clinical setting, the appearance of an enhancing mass should suggest the possibility of a CGD-related hepatic abscess. JF - American Journal of Roentgenology AU - Garcia-Eulate, R AU - Hussain, N AU - Heller, T AU - Kleiner, D AU - Malech, H AU - Holland, S AU - Choyke, P L AD - Molecular Imaging Program, National Cancer Institute, Bldg. 10, Rm. B3B69, 9000 Rockville Pike, Bethesda, MD 20892, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 482 EP - 490 VL - 187 IS - 2 SN - 0361-803X, 0361-803X KW - Toxicology Abstracts; Immunology Abstracts KW - Magnetic resonance imaging KW - Chronic infection KW - Liver KW - Immunodeficiency KW - Abscesses KW - Chronic granulomatous disease KW - Children KW - X 24310:Pharmaceuticals KW - F 06935:Development, Aging & Organ Systems UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20679066?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+Journal+of+Roentgenology&rft.atitle=CT+and+MRI+of+Hepatic+Abscess+in+Patients+with+Chronic+Granulomatous+Disease&rft.au=Garcia-Eulate%2C+R%3BHussain%2C+N%3BHeller%2C+T%3BKleiner%2C+D%3BMalech%2C+H%3BHolland%2C+S%3BChoyke%2C+P+L&rft.aulast=Garcia-Eulate&rft.aufirst=R&rft.date=2006-08-01&rft.volume=187&rft.issue=2&rft.spage=482&rft.isbn=&rft.btitle=&rft.title=American+Journal+of+Roentgenology&rft.issn=0361803X&rft_id=info:doi/10.2214%2FAJR.05.1386 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-07-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Chronic infection; Magnetic resonance imaging; Immunodeficiency; Liver; Children; Chronic granulomatous disease; Abscesses DO - http://dx.doi.org/10.2214/AJR.05.1386 ER - TY - JOUR T1 - Kinase activity is required for the toxic effects of mutant LRRK2/dardarin AN - 20543175; 8068925 AB - Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large protein, and mutations are found throughout the gene including the kinase domain. However, it is not clear if kinase activity is important for the damaging effects of pathogenic mutations. In this study, we noted two cellular phenotypes associated with mutant dardarin. First, pathogenic mutations increase the tendency of dardarin to form inclusion bodies. Secondly, neurons and neuronal cell lines undergo cell death after expression of mutant protein. Manipulating activity by replacing the kinase domain with a 'kinase-dead' version blocks inclusion body formation and strongly delays cell death. This predicts that kinase inhibitors will be useful therapeutic agents in patients with LRRK2 mutations and, perhaps, in sporadic PD. We also show that dardarin protein is expressed within human midbrain neurons and that C-terminal epitopes are also found in some Lewy bodies. JF - Neurobiology of Disease AU - Greggio, Elisa AU - Jain, Shushant AU - Kingsbury, Ann AU - Bandopadhyay, Rina AU - Lewis, Patrick AU - Kaganovich, Alice AU - van der Brug, Marcel P AU - Beilina, Alexandra AU - Blackinton, Jeff AU - Thomas, Kelly Jean AU - Ahmad, Rili AU - Miller, David W AU - Kesavapany, Sashi AU - Singleton, Andrew AU - Lees, Andrew AU - Harvey, Robert J AU - Harvey, Kirsten AU - Cookson, Mark R AD - Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892-3707, USA, kirsten.harvey@pharmacy.ac.uk Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 329 EP - 341 PB - Elsevier Science, The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 23 IS - 2 SN - 0969-9961, 0969-9961 KW - Toxicology Abstracts; CSA Neurosciences Abstracts KW - LRRK2 KW - Kinase KW - Parkinson's disease KW - alpha -Synuclein KW - Substantia nigra KW - Coding KW - LRRK2 protein KW - Lewy bodies KW - Mesencephalon KW - Neurodegenerative diseases KW - Nervous system KW - Cell death KW - Movement disorders KW - Neurons KW - Inclusion bodies KW - Mutation KW - Epitopes KW - X 24310:Pharmaceuticals KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20543175?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurobiology+of+Disease&rft.atitle=Kinase+activity+is+required+for+the+toxic+effects+of+mutant+LRRK2%2Fdardarin&rft.au=Greggio%2C+Elisa%3BJain%2C+Shushant%3BKingsbury%2C+Ann%3BBandopadhyay%2C+Rina%3BLewis%2C+Patrick%3BKaganovich%2C+Alice%3Bvan+der+Brug%2C+Marcel+P%3BBeilina%2C+Alexandra%3BBlackinton%2C+Jeff%3BThomas%2C+Kelly+Jean%3BAhmad%2C+Rili%3BMiller%2C+David+W%3BKesavapany%2C+Sashi%3BSingleton%2C+Andrew%3BLees%2C+Andrew%3BHarvey%2C+Robert+J%3BHarvey%2C+Kirsten%3BCookson%2C+Mark+R&rft.aulast=Greggio&rft.aufirst=Elisa&rft.date=2006-08-01&rft.volume=23&rft.issue=2&rft.spage=329&rft.isbn=&rft.btitle=&rft.title=Neurobiology+of+Disease&rft.issn=09699961&rft_id=info:doi/10.1016%2Fj.nbd.2006.04.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-04-01 N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - LRRK2 protein; Coding; Parkinson's disease; Lewy bodies; Neurodegenerative diseases; Mesencephalon; Cell death; Nervous system; Movement disorders; Neurons; Inclusion bodies; Mutation; Epitopes DO - http://dx.doi.org/10.1016/j.nbd.2006.04.001 ER - TY - JOUR T1 - A Specific Isoform of Nonmuscle Myosin II-C Is Required for Cytokinesis in a Tumor Cell Line AN - 20247694; 7061714 AB - Nonmuscle myosin IIs play an essential role during cytokinesis. Here, we explore the function of an alternatively spliced isoform of nonmuscle myosin heavy chain (NMHC) II-C, called NMHC II-C1, in the A549 human lung tumor cell line during cytokinesis. NMHC II-C1 contains an insert of 8 amino acids in the head region of NMHC II-C. First, we show that there is a marked increase in both the mRNA encoding NMHC II-C1 and protein in tumor cell lines compared with nontumor cell lines derived from the same tissue. Quantification of the amount of myosin II isoforms in the A549 cells shows that the amounts of NMHC II-A and II-C1 protein are about equal and substantially greater than NMHC II-B. Using specific siRNAs to decrease NMHC II-C1 in cultured A549 cells resulted in a 5.5-fold decrease in the number of cells at 120 h, whereas decreasing NMHC II-A with siRNA does not affect cell proliferation. This decreased proliferation can be rescued by reintroducing NMHC II-C1 but not NMHC II-A or II-B into A549 cells, although noninserted NMHC II-C does rescue to a limited extent. Time lapse video microscopy revealed that loss of NMHC II-C1 leads to a delay in cytokinesis and prolongs it from 2 to 8-10 h. These findings are consistent with the localization of NMHC II-C1 to the intercellular bridge that attaches the two dividing cells during the late phases of cytokinesis. The results suggest a specific function for NMHC II-C1 in cytokinesis in the A549 tumor cell line. JF - Journal of Biological Chemistry AU - Jana, Siddhartha S AU - Kawamoto, Sachiyo AU - Adelstein, Robert S AD - Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1762 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 24662 EP - 24670 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 34 SN - 0021-9258, 0021-9258 KW - Biotechnology and Bioengineering Abstracts KW - Myosin KW - Tumor cell lines KW - Amino acids KW - siRNA KW - Lung KW - Cytokinesis KW - Microscopy KW - Cell proliferation KW - mRNA KW - Alternative splicing KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247694?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=A+Specific+Isoform+of+Nonmuscle+Myosin+II-C+Is+Required+for+Cytokinesis+in+a+Tumor+Cell+Line&rft.au=Jana%2C+Siddhartha+S%3BKawamoto%2C+Sachiyo%3BAdelstein%2C+Robert+S&rft.aulast=Jana&rft.aufirst=Siddhartha&rft.date=2006-08-01&rft.volume=281&rft.issue=34&rft.spage=24662&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-09-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Myosin; Tumor cell lines; Amino acids; siRNA; Lung; Cytokinesis; Microscopy; Cell proliferation; Alternative splicing; mRNA ER - TY - JOUR T1 - Prion Strain-Dependent Differences in Conversion of Mutant Prion Proteins in Cell Culture AN - 20223422; 7129343 AB - Although the protein-only hypothesis proposes that it is the conformation of abnormal prion protein (PrP super(Sc)) that determines strain diversity, the molecular basis of strains remains to be elucidated. In the present study, we generated a series of mutations in the normal prion protein (PrP super(C)) in which a single glutamine residue was replaced with a basic amino acid and compared their abilities to convert to PrP super(Sc) in cultured neuronal N2a58 cells infected with either the Chandler or 22L mouse-adapted scrapie strain. In mice, these strains generate PrP super(Sc) of the same sequence but different conformations, as judged by infrared spectroscopy. Substitutions at codons 97, 167, 171, and 216 generated PrP super(C) that resisted conversion and inhibited the conversion of coexpressed wild-type PrP in both Chandler-infected and 22L-infected cells. Interestingly, substitutions at codons 185 and 218 gave strain-dependent effects. The Q185R and Q185K PrP were efficiently converted to PrP super(Sc) in Chandler-infected but not 22L-infected cells. Conversely, Q218R and Q218H PrP were converted only in 22L-infected cells. Moreover, the Q218K PrP exerted a potent inhibitory effect on the conversion of coexpressed wild-type PrP in Chandler-infected cells but had little effect on 22L-infected cells. These results show that two strains with the same PrP sequence but different conformations have differing abilities to convert the same mutated PrP super(C). JF - Journal of Virology AU - Atarashi, Ryuichiro AU - Sim, Valerie L AU - Nishida, Noriyuki AU - Caughey, Byron AU - Katamine, Shigeru AD - Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 853-8523, Japan. Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 7854 EP - 7862 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 16 SN - 0022-538X, 0022-538X KW - Biotechnology and Bioengineering Abstracts; Virology & AIDS Abstracts; CSA Neurosciences Abstracts KW - Glutamine KW - Amino acids KW - I.R. spectroscopy KW - Prion protein KW - Codons KW - Cell culture KW - Scrapie KW - Mutation KW - W 30945:Fermentation & Cell Culture KW - N3 11027:Neurology & neuropathology KW - V 22380:Prions UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20223422?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Prion+Strain-Dependent+Differences+in+Conversion+of+Mutant+Prion+Proteins+in+Cell+Culture&rft.au=Atarashi%2C+Ryuichiro%3BSim%2C+Valerie+L%3BNishida%2C+Noriyuki%3BCaughey%2C+Byron%3BKatamine%2C+Shigeru&rft.aulast=Atarashi&rft.aufirst=Ryuichiro&rft.date=2006-08-01&rft.volume=80&rft.issue=16&rft.spage=7854&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Glutamine; Amino acids; I.R. spectroscopy; Codons; Prion protein; Cell culture; Scrapie; Mutation ER - TY - JOUR T1 - Research Letter: Discovery of Synthetic Penaeidin Activity against Antibiotic-resistant Fungi AN - 20222468; 7100780 AB - Penaeidins are antimicrobial peptides from shrimp that are constituted by divergent classes of peptide isoforms in an individual organism. Penaeidin sequence variation suggests functional diversity in the host and promises differential activities if applied to treat infections in humans. We have synthesized isoform 4 of penaeidin class 3 from the Atlantic shrimp, Litopenaeus setiferus, by native ligation using three peptide segments. Our synthesis approach led to the discovery of an irreversible side reaction that was successfully suppressed, a discovery, which has particular relevance to the synthesis of cysteine-rich peptides. The antimicrobial activity of full-length penaeidin and the N-terminal proline-rich domain of this isoform were compared with the corresponding peptides of penaeidin class 4 isoform 1 using a wide range of bacteria and fungi. New aspects of penaeidin function are reported that include activity against fungi of the phylum Basidiomycota (Cryptococcus strains), activity against fungi that are pathogenic to humans and effectiveness in the context of antibiotic resistance mechanisms (Cryptococcus and Candida spp.). The proline-rich domain of penaeidin class 4 shows the highest relative antimicrobial activity, while exhibiting no cytotoxicity to human monocytes, and therefore stands out as a potential peptide therapeutic. JF - Chemical Biology & Drug Design AU - Cuthbertson, Brandon J AU - Buellesbach, Erika E AU - Gross, Paul S AD - Brandon J. Cuthbertson, cuthbertsonb@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 120 EP - 127 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 68 IS - 2 SN - 1747-0277, 1747-0277 KW - Northern white shrimp KW - White shrimp KW - Biotechnology and Bioengineering Abstracts KW - Antimicrobial activity KW - Cytotoxicity KW - Litopenaeus setiferus KW - Side reactions KW - Candida KW - Drug development KW - Cryptococcus KW - Monocytes KW - Infection KW - Antimicrobial peptides KW - Antibiotic resistance KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20222468?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Chemical+Biology+%26+Drug+Design&rft.atitle=Research+Letter%3A+Discovery+of+Synthetic+Penaeidin+Activity+against+Antibiotic-resistant+Fungi&rft.au=Cuthbertson%2C+Brandon+J%3BBuellesbach%2C+Erika+E%3BGross%2C+Paul+S&rft.aulast=Cuthbertson&rft.aufirst=Brandon&rft.date=2006-08-01&rft.volume=68&rft.issue=2&rft.spage=120&rft.isbn=&rft.btitle=&rft.title=Chemical+Biology+%26+Drug+Design&rft.issn=17470277&rft_id=info:doi/10.1111%2Fj.1747-0285.2006.00417.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - SuppNotes - Figures, 3; tables, 2. N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Cytotoxicity; Antimicrobial activity; Side reactions; Drug development; Monocytes; Infection; Antimicrobial peptides; Antibiotic resistance; Litopenaeus setiferus; Candida; Cryptococcus DO - http://dx.doi.org/10.1111/j.1747-0285.2006.00417.x ER - TY - JOUR T1 - Cisplatin Inhibition of Anthrax Lethal Toxin AN - 20011208; 7127086 AB - Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells. We found that mouse macrophages were protected from toxin by the antitumor drug cis-diammineplatinum (II) dichloride (cisplatin). Cisplatin was shown to inhibit LT-mediated cleavage of cellular mitogen-activated protein kinases (MEKs) without inhibiting LF's in vitro proteolytic activity. Cisplatin-treated PA lost 100% of its ability to function in toxicity assays when paired with untreated LF, despite maintaining the ability to bind to cells. Cisplatin-treated PA was unable to form heptameric oligomers required for LF binding and translocation. The drug was shown to modify PA in a reversible noncovalent manner. Not surprisingly, cisplatin also blocked the actions of anthrax edema toxin and of LF-Pseudomonas aeruginosa exotoxin A fusion peptide (FP59), both of which require PA for translocation. Treatment of BALB/cJ mice or Fischer F344 rats with cisplatin at biologically relevant concentrations completely protected the animals from a coadministered lethal dose of LT. However, treatment with cisplatin 2 hours before or after animals received a lethal bolus of toxin did not protect them. JF - Antimicrobial Agents & Chemotherapy AU - Moayeri, Mahtab AU - Wiggins, Jason F AU - Lindeman, Robin E AU - Leppla, Stephen H AD - Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2658 EP - 2665 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 50 IS - 8 SN - 0066-4804, 0066-4804 KW - Toxicology Abstracts; Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Macrophages KW - Anthrax lethal toxin KW - MAP kinase KW - Lethal factor KW - protective antigen KW - Edema KW - Toxicity KW - Bacillus anthracis KW - exotoxin A KW - Antimicrobial agents KW - Cisplatin KW - Anthrax KW - Inbreeding KW - Drugs KW - Translocation KW - Lethal dose KW - J 02410:Animal Diseases KW - A 01340:Antibiotics & Antimicrobials KW - X 24370:Natural Toxins UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20011208?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Antimicrobial+Agents+%26+Chemotherapy&rft.atitle=Cisplatin+Inhibition+of+Anthrax+Lethal+Toxin&rft.au=Moayeri%2C+Mahtab%3BWiggins%2C+Jason+F%3BLindeman%2C+Robin+E%3BLeppla%2C+Stephen+H&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2006-08-01&rft.volume=50&rft.issue=8&rft.spage=2658&rft.isbn=&rft.btitle=&rft.title=Antimicrobial+Agents+%26+Chemotherapy&rft.issn=00664804&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Proteolysis; Anthrax lethal toxin; MAP kinase; Lethal factor; protective antigen; Edema; Toxicity; exotoxin A; Antimicrobial agents; Cisplatin; Anthrax; Inbreeding; Translocation; Drugs; Lethal dose; Bacillus anthracis ER - TY - JOUR T1 - Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets AN - 19849757; 6978750 AB - In our earlier attempt to identify genes involved in the maintenance of cellular pluripotency, we found that KH-domain protein Embryonal stem cell-specific gene 1 (Esg1) showed similar expression patterns to those of Oct3/4 (Pou5f1), whereas the forced repression of Oct3/4 in mouse embryonic stem cells immediately downregulated the expression of Esg1. Here we further confirm this overlap by in situ hybridization and immunohistochemical analyses. Both Esg1 transcript and protein exist in the egg and preimplantation embryos. At embryonic day 3.5, blastocyst stage, however, ESG1 protein was more abundant in the inner cell mass (ICM) than in trophectoderm (TE), whereas Esg1 transcript was detected in both the ICM and the TE, particularly in the polar trophectoderm. The presence of an RNA-binding KH-domain in ESG1 led us to search for and identify 902 target transcripts by microarray analysis of immunoprecipitated ESG1 complex. Interaction of 20 target mRNA with ESG1, including Cdc25a, Cdc42, Ezh2, Nfyc and Nr5a2, was further validated by reverse transcriptase-polymerase chain reaction of the immunoprecipitation material, supporting the notion that ESG1 is an RNA-binding protein which associates with specific target transcripts. JF - Development Growth & Differentiation AU - Tanaka, Tetsuya S AU - Lopez de Silanes, Isabel AU - Sharova, Lioudmila V AU - Akutsu, Hidenori AU - Yoshikawa, Toshiyuki AU - Amano, Hisayuki AU - Yamanaka, Shinya AU - Gorospe, Myriam AU - Ko, Minoru SH AD - Laboratory of Genetics, kom@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 381 EP - 390 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 48 IS - 6 SN - 0012-1592, 0012-1592 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts; Genetics Abstracts KW - RNA-binding protein KW - Immunoprecipitation KW - Transcription KW - trophectoderm KW - Cdc42 protein KW - DNA microarrays KW - Differentiation KW - Stem cells KW - blastocysts KW - Embryo cells KW - Polymerase chain reaction KW - Oct-4 protein KW - G 07730:Development & Cell Cycle KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19849757?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Development+Growth+%26+Differentiation&rft.atitle=Esg1%2C+expressed+exclusively+in+preimplantation+embryos%2C+germline%2C+and+embryonic+stem+cells%2C+is+a+putative+RNA-binding+protein+with+broad+RNA+targets&rft.au=Tanaka%2C+Tetsuya+S%3BLopez+de+Silanes%2C+Isabel%3BSharova%2C+Lioudmila+V%3BAkutsu%2C+Hidenori%3BYoshikawa%2C+Toshiyuki%3BAmano%2C+Hisayuki%3BYamanaka%2C+Shinya%3BGorospe%2C+Myriam%3BKo%2C+Minoru+SH&rft.aulast=Tanaka&rft.aufirst=Tetsuya&rft.date=2006-08-01&rft.volume=48&rft.issue=6&rft.spage=381&rft.isbn=&rft.btitle=&rft.title=Development+Growth+%26+Differentiation&rft.issn=00121592&rft_id=info:doi/10.1111%2Fj.1440-169X.2006.00875.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 3; tables, 2; references, 46. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Differentiation; blastocysts; Stem cells; RNA-binding protein; Embryo cells; Immunoprecipitation; Polymerase chain reaction; trophectoderm; Transcription; Cdc42 protein; Oct-4 protein; DNA microarrays DO - http://dx.doi.org/10.1111/j.1440-169X.2006.00875.x ER - TY - JOUR T1 - Cloning technologies for protein expression and purification AN - 19848079; 7003409 AB - Detailed knowledge of the biochemistry and structure of individual proteins is fundamental to biomedical research. To further our understanding, however, proteins need to be purified in sufficient quantities, usually from recombinant sources. Although the sequences of genomes are now produced in automated factories purified proteins are not, because their behavior is much more variable. The construction of plasmids and viruses to overexpress proteins for their purification is often tedious. Alternatives to traditional methods that are faster, easier and more flexible are needed and are becoming available. JF - Current Opinion in Biotechnology AU - Hartley, James L AD - super(a)Protein Expression Laboratory, Research Technology Program, SAIC- Frederick, Inc., NCI-Frederick, Frederick, Maryland 21702, USA, hartley@ncifcrf.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 359 EP - 366 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0958-1669, 0958-1669 KW - Virology & AIDS Abstracts; Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Genomes KW - Protein structure KW - Reviews KW - protein purification KW - Plasmids KW - W3 33243:Molecular methods KW - W 30965:Miscellaneous, Reviews KW - V 22310:Genetics, Taxonomy & Structure KW - W2 32243:Molecular methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848079?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Cloning+technologies+for+protein+expression+and+purification&rft.au=Hartley%2C+James+L&rft.aulast=Hartley&rft.aufirst=James&rft.date=2006-08-01&rft.volume=17&rft.issue=4&rft.spage=359&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.06.011 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein structure; Genomes; Reviews; protein purification; Plasmids DO - http://dx.doi.org/10.1016/j.copbio.2006.06.011 ER - TY - JOUR T1 - Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells AN - 19846876; 7094295 AB - The beta -herpesvirus human herpesvirus-6 (HHV-6) is becoming increasingly recognized as an important pathogen in immunocompromised patients, particularly in post bone marrow transplant (BMT). Reactivation of latent HHV-6 resulting in encephalitis has been reported in BMT and stem cell transplant (SCT) patients. The development of HHV-6 encephalitis can be a fatal complication, the frequency of which is increasing likely due to improved diagnosis with quantitative polymerase chain reaction (PCR) of cerebrospinal fluid. There are currently no antiviral compounds approved for HHV-6, nor have any controlled clinical trials been conducted. The frequency and severity of HHV-6 encephalitis in both immunocompetent and immunocompromised patients necessitates studies on the usefulness of currently available anti-viral compounds. The authors compared the antiviral efficacy of four drugs currently used for cytomegalovirus (CMV) infection, a beta -herpesvirus sharing ho-mology with HHV-6, In HHV-6A- and HHV-6B-infected T cells, acyclovir, gan-ciclovir, foscarnet, and cidofovir exhibited antiviral activity consistent with that published in other studies. In HHV-6-infected human astrocytes (U251), however, only foscarnet and cidofovir exhibited antiviral activity and this effect was restricted to infection with HHV-6 variant A. In pathological brain sections from patients with neurological disorders such as multiple sclerosis and epilepsy, HHV-6 has been localized to glial cells. Determination of antiviral activity in human glial fibrillary acidic protein (GFAP)-positive astrocytes of currently used antiviral compounds is essential for potential treatment of HHV-6 and neurological disorders. Our data highlight the necessity for further study of antiviral compound in HHV-6-infected glial cells as well as the development of more selective compounds for HHV-6. JF - Journal of Neurovirology AU - Akhyani, N AU - Fotheringham, J AU - Yao, K AU - Rashti, F AU - Jacobson, S AD - Viral Immunology Section, NINDS/NIH, 10 Center Drive, Building 10 Room 5B16, Bethesda, MD 20892, USA, jacobsons@ninds.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 284 EP - 293 VL - 12 IS - 4 SN - 1355-0284, 1355-0284 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; CSA Neurosciences Abstracts; Virology & AIDS Abstracts KW - Neurological diseases KW - Astrocytes KW - Glial cells KW - Glial fibrillary acidic protein KW - Human herpesvirus 6 KW - Infection KW - acyclovir KW - Cytomegalovirus KW - Clinical trials KW - Transplants KW - Cerebrospinal fluid KW - Antiviral agents KW - Lymphocytes T KW - Polymerase chain reaction KW - Bone marrow transplantation KW - Cidofovir KW - Data processing KW - Multiple sclerosis KW - Brain KW - Pathogens KW - Antiviral activity KW - Encephalitis KW - foscarnet KW - Epilepsy KW - Immunocompromised hosts KW - A 01340:Antibiotics & Antimicrobials KW - V 22340:Antiviral Agents KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19846876?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Neurovirology&rft.atitle=Efficacy+of+antiviral+compounds+in+human+herpesvirus-6-infected+glial+cells&rft.au=Akhyani%2C+N%3BFotheringham%2C+J%3BYao%2C+K%3BRashti%2C+F%3BJacobson%2C+S&rft.aulast=Akhyani&rft.aufirst=N&rft.date=2006-08-01&rft.volume=12&rft.issue=4&rft.spage=284&rft.isbn=&rft.btitle=&rft.title=Journal+of+Neurovirology&rft.issn=13550284&rft_id=info:doi/10.1080%2F13550280600880772 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cidofovir; Data processing; Neurological diseases; Astrocytes; Multiple sclerosis; Glial cells; Brain; Glial fibrillary acidic protein; Pathogens; acyclovir; Antiviral activity; Infection; Clinical trials; Encephalitis; Transplants; Cerebrospinal fluid; foscarnet; Antiviral agents; Epilepsy; Immunocompromised hosts; Lymphocytes T; Polymerase chain reaction; Bone marrow transplantation; Human herpesvirus 6; Cytomegalovirus DO - http://dx.doi.org/10.1080/13550280600880772 ER - TY - JOUR T1 - Slicing a protease: Structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains AN - 19778416; 7130032 AB - ATP-dependent Lon proteases are multi-domain enzymes found in all living organisms. All Lon proteases contain an ATPase domain belonging to the AAA super(+) superfamily of molecular machines and a proteolytic domain with a serine-lysine catalytic dyad. Lon proteases can be divided into two subfamilies, LonA and LonB, exemplified by the Escherichia coli and Archaeoglobus fulgidus paralogs, respectively. The LonA subfamily is defined by the presence of a large N-terminal domain, whereas the LonB subfamily has no such domain, but has a membrane-spanning domain that anchors the protein to the cytoplasmic side of the membrane. The two subfamilies also differ in their consensus sequences. Recent crystal structures for several individual domains and sub-fragments of Lon proteases have begun to illuminate similarities and differences in structure-function relationships between the two subfamilies. Differences in orientation of the active site residues in several isolated Lon protease domains point to possible roles for the AAA super(+) domains and/or substrates in positioning the catalytic residues within the active site. Structures of the proteolytic domains have also indicated a possible hexameric arrangement of subunits in the native state of bacterial Lon proteases. The structure of a large segment of the N-terminal domain has revealed a folding motif present in other protein families of unknown function and should lead to new insights regarding ways in which Lon interacts with substrates or other cellular factors. These first glimpses of the structure of Lon are heralding an exciting new era of research on this ancient family of proteases. JF - Protein Science AU - Rotanova, Tatyana V AU - Botos, Istvan AU - Melnikov, Edward E AU - Rasulova, Fatima AU - Gustchina, Alla AU - Maurizi, Michael R AU - Wlodawer, Alexander AD - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland 20892, USA. Laboratory of Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA. Enteric Diseases Department, Infectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland 20910, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1815 EP - 1828 PB - Cold Spring Harbor Laboratory Press, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 15 IS - 8 SN - 0961-8368, 0961-8368 KW - Microbiology Abstracts B: Bacteriology KW - Proteolysis KW - Adenosinetriphosphatase KW - Lon protein KW - Structure-function relationships KW - Archaeoglobus fulgidus KW - Escherichia coli KW - Crystal structure KW - protein families KW - Enzymes KW - Proteinase KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19778416?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Protein+Science&rft.atitle=Slicing+a+protease%3A+Structural+features+of+the+ATP-dependent+Lon+proteases+gleaned+from+investigations+of+isolated+domains&rft.au=Rotanova%2C+Tatyana+V%3BBotos%2C+Istvan%3BMelnikov%2C+Edward+E%3BRasulova%2C+Fatima%3BGustchina%2C+Alla%3BMaurizi%2C+Michael+R%3BWlodawer%2C+Alexander&rft.aulast=Rotanova&rft.aufirst=Tatyana&rft.date=2006-08-01&rft.volume=15&rft.issue=8&rft.spage=1815&rft.isbn=&rft.btitle=&rft.title=Protein+Science&rft.issn=09618368&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2009-05-01 N1 - Last updated - 2015-03-30 N1 - SubjectsTermNotLitGenreText - Proteolysis; Adenosinetriphosphatase; Structure-function relationships; Lon protein; Crystal structure; Enzymes; protein families; Proteinase; Archaeoglobus fulgidus; Escherichia coli ER - TY - JOUR T1 - Immunity to Recombinant Plasmodium falciparum Merozoite Surface Protein 1 (MSP1): Protection in Aotus nancymai Monkeys Strongly Correlates with Anti-MSP1 Antibody Titer and In Vitro Parasite-Inhibitory Activity AN - 19778363; 7128394 AB - A number of malarial blood-stage candidate vaccines are currently being tested in human clinical trials, but our understanding of the relationship between clinical immunity and data obtained from in vitro assays remains inadequate. An in vitro assay which could reliably predict protective immunity in vivo would facilitate vaccine development. Merozoite surface protein1 (MSP1) is a leading blood-stage malaria vaccine candidate, and anti-MSP1 antibodies from individuals that are clinically immune to malaria inhibit the invasion of Plasmodium merozoites into erythrocytes in vitro. Using expression in Escherichia coli and subsequent refolding, we have produced two allelic forms of MSP1 sub(42) (FVO and 3D7). Aotus nancymai monkeys were immunized with MSP1 sub(42)-FVO, MSP1 sub(42)-3D7, or a combination of FVO and 3D7 allelic forms, (MSP1 sub(42)-C1) and were subsequently challenged with Plasmodium falciparum FVO parasites. Sera obtained prior to challenge were tested by standardized enzyme-linked immunosorbent assay (ELISA) to determine antibody titer, and immunoglobulin G (IgG) fractions were also obtained from the same sera; the IgG fractions were tested in an in vitro growth inhibition (GI) assay to evaluate biological activity of the antibodies. Regardless of the immunogen used, all monkeys that had >200,000 ELISA units against MSP1 sub(42)-FVO antigen before challenge controlled their infections. By contrast, all monkeys whose purified IgGs gave <60% inhibition activity in an in vitro GI assay with P. falciparum FVO required treatment for high parasitemia after challenge. There is a strong correlation between ELISA units (Spearman rank correlation of greater than 0.75) or GI activity (Spearman rank correlation of greater than 0.70) and protective immunity judged by various parameters (e.g., cumulative parasitemia or day of patency). These data indicate that, in this monkey model, the ELISA and GI assay values can significantly predict protective immunity induced by a blood-stage vaccine, and they support the use of these assays as part of evaluation of human clinical trials of MSP1-based vaccines. JF - Infection and Immunity AU - Singh, Sanjay AU - Miura, Kazutoyo AU - Zhou, Hong AU - Muratova, Olga AU - Keegan, Brian AU - Miles, Aaron AU - Martin, Laura B AU - Saul, Allan J AU - Miller, Louis H AU - Long, Carole A AD - Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, Maryland 20852 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 4573 EP - 4580 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 8 SN - 0019-9567, 0019-9567 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Microbiology Abstracts C: Algology, Mycology & Protozoology KW - Parasites KW - Enzyme-linked immunosorbent assay KW - Data processing KW - Aotus KW - Erythrocytes KW - Merozoite surface protein 1 KW - Malaria KW - Plasmodium falciparum KW - Immunity KW - Infection KW - Clinical trials KW - Models KW - parasitemia KW - Escherichia coli KW - Immunoglobulin G KW - Merozoites KW - Vaccines KW - K 03350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19778363?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Immunity+to+Recombinant+Plasmodium+falciparum+Merozoite+Surface+Protein+1+%28MSP1%29%3A+Protection+in+Aotus+nancymai+Monkeys+Strongly+Correlates+with+Anti-MSP1+Antibody+Titer+and+In+Vitro+Parasite-Inhibitory+Activity&rft.au=Singh%2C+Sanjay%3BMiura%2C+Kazutoyo%3BZhou%2C+Hong%3BMuratova%2C+Olga%3BKeegan%2C+Brian%3BMiles%2C+Aaron%3BMartin%2C+Laura+B%3BSaul%2C+Allan+J%3BMiller%2C+Louis+H%3BLong%2C+Carole+A&rft.aulast=Singh&rft.aufirst=Sanjay&rft.date=2006-08-01&rft.volume=74&rft.issue=8&rft.spage=4573&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Parasites; Enzyme-linked immunosorbent assay; Data processing; Erythrocytes; Malaria; Merozoite surface protein 1; Immunity; Infection; Clinical trials; Models; parasitemia; Immunoglobulin G; Merozoites; Vaccines; Aotus; Escherichia coli; Plasmodium falciparum ER - TY - JOUR T1 - Enhancement of soluble protein expression through the use of fusion tags AN - 19773578; 7003408 AB - The soluble expression of heterologous proteins in Escherichia coli remains a serious bottleneck in protein production. Although alteration of expression conditions can sometimes solve the problem, the best available tools to date have been fusion tags that enhance the solubility of expressed proteins. However, a systematic analysis of the utility of these solubility fusions has been difficult, and it appears that many proteins react differently to the presence of different solubility tags. The advent of high-throughput structural genomics programs and advances in cloning and expression technology afford us a new way to compare the effectiveness of solubility tags. This data should allow us to better predict the effectiveness of tags currently in use, and might also provide the information needed to identify new fusion tags. JF - Current Opinion in Biotechnology AU - Esposito, Dominic AU - Chatterjee, Deb K AD - super(a)Protein Expression Laboratory, Research Technology Program, SAIC- Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA, chatterjee@ncifcrf.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 353 EP - 358 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0958-1669, 0958-1669 KW - Microbiology Abstracts B: Bacteriology; Biotechnology and Bioengineering Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Solubility KW - Protein biosynthesis KW - Data processing KW - Reviews KW - Escherichia coli KW - genomics KW - J 02310:Genetics & Taxonomy KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773578?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Enhancement+of+soluble+protein+expression+through+the+use+of+fusion+tags&rft.au=Esposito%2C+Dominic%3BChatterjee%2C+Deb+K&rft.aulast=Esposito&rft.aufirst=Dominic&rft.date=2006-08-01&rft.volume=17&rft.issue=4&rft.spage=353&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.06.003 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; Protein biosynthesis; Solubility; Reviews; genomics; Escherichia coli DO - http://dx.doi.org/10.1016/j.copbio.2006.06.003 ER - TY - JOUR T1 - Subunit Recombinant Vaccine Protects against Monkeypox AN - 19773087; 7132018 AB - The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. Because Abs to VACV mediate protection, a live virus vaccine could be substituted by a safe subunit protein-based vaccine able to induce a protective Ab response. We immunized rhesus macaques with plasmid DNA encoding the monkeypox orthologs of the VACV L1R, A27L, A33R, and B5R proteins by the intradermal and i.m. routes, either alone or in combination with the equivalent recombinant proteins produced in Escherichia coli. Animals that received only DNA failed to produce high titer Abs, developed innumerable skin lesions after challenge, and died in a manner similar to placebo controls. By contrast, the animals vaccinated with proteins developed moderate to severe disease (20-155 skin lesions) but survived. Importantly, those immunized with DNA and boosted with proteins had mild disease with 15 or fewer lesions that resolved within days. DNA/protein immunization elicited Th responses and binding Ab titers to all four proteins that correlated negatively with the total lesion number. The sera of the immunized macaques recognized a limited number of linear B cell epitopes that are highly conserved among orthopoxviruses. Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox. JF - Journal of Immunology AU - Heraud, Jean-Michel AU - Edghill-Smith, Yvette AU - Ayala, Victor AU - Kalisz, Irene AU - Parrino, Janie AU - Kalyanaraman, Vaniambadi S AU - Manischewitz, Jody AU - King, Lisa R AU - Hryniewicz, Anna AU - Trindade, Christopher J AU - Hassett, Meredith AU - Tsai, Wen-Po AU - Venzon, David AU - Nalca, Aysegul AU - Vaccari, Monica AU - Silvera, Peter AU - Bray, Mike AU - Graham, Barney S AU - Golding, Hana AU - Hooper, Jay W AU - Franchini, Genoveffa AD - Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892. Southern Research Institute, Frederick, MD 21701. Advanced BioScience Laboratories, Kensington, MD 20895. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892. Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD 20892. Department of General and Experimental Pathology, Medical University of Bialystok, Bialystok, Poland. Biostatistics and Data Management Section, National Cancer Institute, Bethesda, MD 20892. U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702. Biodefense Clinical Research Branch, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2552 EP - 2564 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 4 SN - 0022-1767, 0022-1767 KW - Rhesus macaque KW - Rhesus monkey KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Monkeypox KW - Lymphocytes B KW - Antibody response KW - Plasmids KW - Immunization KW - Smallpox KW - Antibodies KW - Vaccinia virus KW - Skin diseases KW - Escherichia coli KW - DNA KW - Macaca mulatta KW - Vaccines KW - Epitopes KW - V 22350:Immunology KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19773087?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Subunit+Recombinant+Vaccine+Protects+against+Monkeypox&rft.au=Heraud%2C+Jean-Michel%3BEdghill-Smith%2C+Yvette%3BAyala%2C+Victor%3BKalisz%2C+Irene%3BParrino%2C+Janie%3BKalyanaraman%2C+Vaniambadi+S%3BManischewitz%2C+Jody%3BKing%2C+Lisa+R%3BHryniewicz%2C+Anna%3BTrindade%2C+Christopher+J%3BHassett%2C+Meredith%3BTsai%2C+Wen-Po%3BVenzon%2C+David%3BNalca%2C+Aysegul%3BVaccari%2C+Monica%3BSilvera%2C+Peter%3BBray%2C+Mike%3BGraham%2C+Barney+S%3BGolding%2C+Hana%3BHooper%2C+Jay+W%3BFranchini%2C+Genoveffa&rft.aulast=Heraud&rft.aufirst=Jean-Michel&rft.date=2006-08-01&rft.volume=177&rft.issue=4&rft.spage=2552&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Smallpox; Antibodies; Monkeypox; Skin diseases; Lymphocytes B; DNA; Antibody response; Vaccines; Plasmids; Immunization; Epitopes; Vaccinia virus; Escherichia coli; Macaca mulatta ER - TY - JOUR T1 - Mutator and Antimutator Effects of the Bacteriophage P1 hot Gene Product AN - 19772032; 7131608 AB - The Hot (homolog of theta) protein of bacteriophage P1 can substitute for the Escherichia coli DNA polymerase III theta subunit, as evidenced by its stabilizing effect on certain dnaQ mutants that carry an unstable polymerase III epsilon proofreading subunit (antimutator effect). Here, we show that Hot can also cause an increase in the mutability of various E. coli strains (mutator effect). The hot mutator effect differs from the one caused by the lack of theta . Experiments using chimeric theta /Hot proteins containing various domains of Hot and theta along with a series of point mutants show that both N- and C-terminal parts of each protein are important for stabilizing the epsilon subunit. In contrast, the N-terminal part of Hot appears uniquely responsible for its mutator activity. JF - Journal of Bacteriology AU - Chikova, Anna K AU - Schaaper, Roel M AD - Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709. D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Science, Moscow 123098, Russia Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 5831 EP - 5838 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 16 SN - 0021-9193, 0021-9193 KW - Genetics Abstracts; Virology & AIDS Abstracts; Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Phages KW - DNA-directed DNA polymerase KW - Escherichia coli KW - Proofreading KW - J 02310:Genetics & Taxonomy KW - V 22320:Replication KW - N 14835:Protein-Nucleic Acids Association KW - G 07760:Viruses & Phages UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772032?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Mutator+and+Antimutator+Effects+of+the+Bacteriophage+P1+hot+Gene+Product&rft.au=Chikova%2C+Anna+K%3BSchaaper%2C+Roel+M&rft.aulast=Chikova&rft.aufirst=Anna&rft.date=2006-08-01&rft.volume=188&rft.issue=16&rft.spage=5831&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Phages; DNA-directed DNA polymerase; Proofreading; Escherichia coli ER - TY - JOUR T1 - Ribosomal protein S1 promotes transcriptional cycling AN - 19772026; 7130190 AB - Prokaryotic RNA polymerases are capable of efficient, continuous synthesis of RNA in vivo, yet purified polymerase-DNA model systems for RNA synthesis typically produce only a limited number of catalytic turnovers. Here, we report that the ribosomal protein S1-which plays critical roles in translation initiation and elongation in Escherichia coli and is believed to stabilize mRNA on the ribosome-is a potent activator of transcriptional cycling in vitro. Deletion of the two C-terminal RNA-binding modules-out of a total of six loosely homologous RNA-binding modules present in S1-resulted in a near-loss of the ability of S1 to enhance transcription, whereas disruption of the very last C-terminal RNA-binding module had only a mild effect. We propose that, in vivo, cooperative interaction of multiple RNA-binding modules in S1 may enhance the transcript release from RNA polymerase, alleviating its inhibitory effect and enabling the core enzyme for continuous reinitiation of transcription. JF - RNA AU - Sukhodolets, Maxim V AU - Garges, Susan AU - Adhya, Sankar AD - Department of Chemistry and Physics, Lamar University, Beaumont, Texas 77710, USA. Laboratory of Molecular Biology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland 20892, USA Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1505 EP - 1513 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 12 IS - 8 SN - 1355-8382, 1355-8382 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Elongation KW - Deletion KW - DNA-directed RNA polymerase KW - Translation initiation KW - Ribosomal proteins KW - Escherichia coli KW - ribosomal protein S1 KW - Transcription KW - Enzymes KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19772026?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA&rft.atitle=Ribosomal+protein+S1+promotes+transcriptional+cycling&rft.au=Sukhodolets%2C+Maxim+V%3BGarges%2C+Susan%3BAdhya%2C+Sankar&rft.aulast=Sukhodolets&rft.aufirst=Maxim&rft.date=2006-08-01&rft.volume=12&rft.issue=8&rft.spage=1505&rft.isbn=&rft.btitle=&rft.title=RNA&rft.issn=13558382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Elongation; DNA-directed RNA polymerase; Deletion; Ribosomal proteins; Translation initiation; ribosomal protein S1; Enzymes; Transcription; Escherichia coli ER - TY - JOUR T1 - Matrix Control of Stem Cell Fate AN - 19705703; 7488539 AB - A key challenge in stem cell research is to learn how to direct the differentiation of stem cells toward specific fates. In this issue of Cell, Engler et al. (2006) identify a new factor regulating stem cell fate: the elasticity of the matrix microenvironment. By changing the stiffness of the substrate, human mesenchymal stem cells could be directed along neuronal, muscle, or bone lineages. JF - Cell AU - Even-Ram, Sharona AU - Artym, Vira AU - Yamada, Kenneth M AD - Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA, kyamada@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 645 EP - 647 PB - Cell Press, 1100 Massachusetts Avenue Cambridge MA 02138 USA, [mailto:subs@cell.com], [URL:http://www.cellpress.com] VL - 126 IS - 4 SN - 0092-8674, 0092-8674 KW - Biotechnology and Bioengineering Abstracts; CSA Neurosciences Abstracts; Calcium & Calcified Tissue Abstracts KW - Differentiation KW - Stem cells KW - Muscles KW - Microenvironments KW - Mesenchyme KW - N3 11007:Neurobiology KW - W 30965:Miscellaneous, Reviews KW - T 2025:Bone and Bone Diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19705703?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cell&rft.atitle=Matrix+Control+of+Stem+Cell+Fate&rft.au=Even-Ram%2C+Sharona%3BArtym%2C+Vira%3BYamada%2C+Kenneth+M&rft.aulast=Even-Ram&rft.aufirst=Sharona&rft.date=2006-08-01&rft.volume=126&rft.issue=4&rft.spage=645&rft.isbn=&rft.btitle=&rft.title=Cell&rft.issn=00928674&rft_id=info:doi/10.1016%2Fj.cell.2006.08.008 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-08-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Differentiation; Stem cells; Muscles; Microenvironments; Mesenchyme DO - http://dx.doi.org/10.1016/j.cell.2006.08.008 ER - TY - JOUR T1 - Ozone and Daily Mortality in Shanghai, China AN - 19522873; 7070909 AB - Controversy remains regarding the relationship between ambient ozone and mortality worldwide. In mainland China, the largest developing country, there has been no prior study investigating the acute effect of O sub(3) on death risk. Given the changes in types of air pollution from conventional coal combustion to the mixed coal combustion/motor vehicle emissions in China's large cities, it is worthwhile to investigate the acute effect of O sub(3) on mortality outcomes in the country. We conducted a time-series study to investigate the relation between O sub(3) and daily mortality in Shanghai using 4 years of daily data (2001-2004). We used the generalized additive model with penalized splines to analyze mortality, O sub(3) pollution, and covariate data in warm and cold seasons. We considered daily counts of all-cause mortality and several cause-specific subcategories (respiratory and cardiovascular). We also examined these associations among several subpopulations based on age and sex. O sub(3) was significantly associated with total and cardiovascular mortality in the cold season but not in the warm season. In the whole-year analysis, an increase of 10 mu g/m super(3) of 2-day average (lag01) O sub(3) corresponds to 0.45% [95% confidence interval (CI), 0.16-0.73%], 0.53% (95% CI, 0.10-0.96%), and 0.35% (95% CI, -0.40 to 1.09%) increase of total nonaccidental, cardiovascular, and respiratory mortality, respectively. In the cold season, the estimates increased to 1.38% (95% CI, 0.68-2.07%), 1.53% (95% CI, 0.54-2.52%), and 0.95% (95% CI, -0.71 to 2.60%), respectively. In the warm season, we did not observe significant associations for both total and causespecific mortality. The results were generally insensitive to model specifications such as lag structure of O sub(3) concentrations and degree of freedom for time trend. Multipollutant models indicate that the effect of O sub(3) was not confounded by particulate matter less than or equal to 10 mu m in diameter (PM sub(10)) or by sulfur dioxide; however, after adding nitrogen dioxide into the model, the association of O sub(3) with total and cardiovascular mortality became statistically insignificant. O sub(3) pollution has stronger health effects in the cold than in the warm season in Shanghai. Our analyses also strengthen the rationale for further limiting levels of O sub(3) pollution in outdoor air in the city. JF - Environmental Health Perspectives AU - Zhang, Yunhui AU - Huang, Wei AU - London, S J AU - Song, Guixiang AU - Chen, Guohai AU - Jiang, Lili AU - Zhao, Naiqing AU - Chen, Bingheng AU - Kan, Haidong AD - Epidemiology Branch, NIEHS, P.O. Box 12233, Mail Drop A3-05, Research Triangle Park, NC 27709, USA, kanh@niehs.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1227 EP - 1232 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - Risk Abstracts; Health & Safety Science Abstracts; Pollution Abstracts; Toxicology Abstracts KW - Motor vehicles KW - Particulate matter KW - Elderly KW - Statistical analysis KW - Pollution effects KW - Environmental health KW - Particulates KW - Coal KW - Models KW - Nitrogen dioxide KW - Acute effects KW - Sulfur dioxide KW - Pollution KW - Urban areas KW - Ozone KW - Mortality KW - Subpopulations KW - Combustion KW - Air pollution KW - China, People's Rep. KW - China, People's Rep., Shanghai KW - Automotive exhaust emissions KW - Cardiovascular diseases KW - Developing countries KW - X 24490:Other KW - R2 23060:Medical and environmental health KW - H 12000:Epidemiology and Public Health KW - P 6000:TOXICOLOGY AND HEALTH UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19522873?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Ozone+and+Daily+Mortality+in+Shanghai%2C+China&rft.au=Zhang%2C+Yunhui%3BHuang%2C+Wei%3BLondon%2C+S+J%3BSong%2C+Guixiang%3BChen%2C+Guohai%3BJiang%2C+Lili%3BZhao%2C+Naiqing%3BChen%2C+Bingheng%3BKan%2C+Haidong&rft.aulast=Zhang&rft.aufirst=Yunhui&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1227&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.9014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Mortality; Subpopulations; Motor vehicles; Particulate matter; Statistical analysis; Coal; Models; Combustion; Acute effects; Air pollution; Nitrogen dioxide; Sulfur dioxide; Cardiovascular diseases; Developing countries; Pollution; Ozone; Elderly; Environmental health; Pollution effects; Particulates; Automotive exhaust emissions; Urban areas; China, People's Rep., Shanghai; China, People's Rep. DO - http://dx.doi.org/10.1289/ehp.9014 ER - TY - JOUR T1 - Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries AN - 19468212; 7132630 AB - High-throughput screening (HTS) of chemical compounds to identify modulators of molecular targets is a mainstay of pharmaceutical development. Increasingly, HTS is being used to identify chemical probes of gene, pathway, and cell functions, with the ultimate goal of comprehensively delineating relationships between chemical structures and biological activities. Achieving this goal will require methodologies that efficiently generate pharmacological data from the primary screen and reliably profile the range of biological activities associated with large chemical libraries. Traditional HTS, which tests compounds at a single concentration, is not suited to this task, because HTS is burdened by frequent false positives and false negatives and requires extensive follow-up testing. We have developed a paradigm, quantitative HTS (qHTS), tested with the enzyme pyruvate kinase, to generate concentration-response curves for >60,000 compounds in a single experiment. We show that this method is precise, refractory to variations in sample preparation, and identifies compounds with a wide range of activities. Concentration-response curves were classified to rapidly identify pyruvate kinase activators and inhibitors with a variety of potencies and efficacies and elucidate structure-activity relationships directly from the primary screen. Comparison of qHTS with traditional single-concentration HTS revealed a high prevalence of false negatives in the single-point screen. This study demonstrates the feasibility of qHTS for accurately profiling every compound in large chemical libraries (>10 super(5) compounds). qHTS produces rich data sets that can be immediately mined for reliable biological activities, thereby providing a platform for chemical genomics and accelerating the identification of leads for drug discovery. JF - Proceedings of the National Academy of Sciences, USA AU - Inglese, James AU - Auld, Douglas S AU - Jadhav, Ajit AU - Johnson, Ronald L AU - Simeonov, Anton AU - Yasgar, Adam AU - Zheng, Wei AU - Austin, Christopher P AD - NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-3370 Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 11473 EP - 11478 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 31 SN - 0027-8424, 0027-8424 KW - Biotechnology and Bioengineering Abstracts KW - Drug discovery KW - DNA probes KW - Pharmaceuticals KW - Enzymes KW - high-throughput screening KW - genomics KW - Structure-activity relationships KW - Pyruvate kinase KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19468212?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Quantitative+high-throughput+screening%3A+A+titration-based+approach+that+efficiently+identifies+biological+activities+in+large+chemical+libraries&rft.au=Inglese%2C+James%3BAuld%2C+Douglas+S%3BJadhav%2C+Ajit%3BJohnson%2C+Ronald+L%3BSimeonov%2C+Anton%3BYasgar%2C+Adam%3BZheng%2C+Wei%3BAustin%2C+Christopher+P&rft.aulast=Inglese&rft.aufirst=James&rft.date=2006-08-01&rft.volume=103&rft.issue=31&rft.spage=11473&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Pyruvate kinase; high-throughput screening; DNA probes; Drug discovery; genomics; Structure-activity relationships; Enzymes; Pharmaceuticals ER - TY - JOUR T1 - caGrid: design and implementation of the core architecture of the cancer biomedical informatics grid AN - 19465721; 7130853 AB - MOTIVATION: The complexity of cancer is prompting researchers to find new ways to synthesize information from diverse data sources and to carry out coordinated research efforts that span multiple institutions. There is a need for standard applications, common data models, and software infrastructure to enable more efficient access to and sharing of distributed computational resources in cancer research. To address this need the National Cancer Institute (NCI) has initiated a national-scale effort, called the cancer Biomedical Informatics Grid (caBIG super(TM)), to develop a federation of interoperable research information systems. RESULTS: At the heart of the caBIG approach to federated interoperability effort is a Grid middleware infrastructure, called caGrid. In this paper we describe the caGrid framework and its current implementation, caGrid version 0.5. caGrid is a model-driven and service-oriented architecture that synthesizes and extends a number of technologies to provide a standardized framework for the advertising, discovery, and invocation of data and analytical resources. We expect caGrid to greatly facilitate the launch and ongoing management of coordinated cancer research studies involving multiple institutions, to provide the ability to manage and securely share information and analytic resources, and to spur a new generation of research applications that empower researchers to take a more integrative, trans-domain approach to data mining and analysis. AVAILABILITY: The caGrid version 0.5 release can be downloaded from https://cabig.nci.nih.gov/workspaces/Architecture/caGrid/. The operational test bed Grid can be accessed through the client included in the release, or through the caGrid-browser web application http://cagrid-browser.nci.nih.gov. CONTACT: joel.saltzsumc.edu JF - Bioinformatics AU - Saltz, Joel AU - Oster, Scott AU - Hastings, Shannon AU - Langella, Stephen AU - Kurc, Tahsin AU - Sanchez, William AU - Kher, Manav AU - Manisundaram, Arumani AU - Shanbhag, Krishnakant AU - Covitz, Peter AD - Department of Biomedical Informatics, Ohio State University 3184 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210, USA. Science Applications International Corporation Annapolis, MD, USA. Booz Allen Hamilton, Inc. Rockville, MD, USA. National Cancer Institute Center for Bioinformatics Rockville, MD, USA Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 1910 EP - 1916 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 22 IS - 15 SN - 1367-4803, 1367-4803 KW - Biotechnology and Bioengineering Abstracts KW - Heart KW - Computer programs KW - software KW - Data processing KW - Bioinformatics KW - Computer applications KW - Cancer KW - Models KW - Information systems KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19465721?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioinformatics&rft.atitle=caGrid%3A+design+and+implementation+of+the+core+architecture+of+the+cancer+biomedical+informatics+grid&rft.au=Saltz%2C+Joel%3BOster%2C+Scott%3BHastings%2C+Shannon%3BLangella%2C+Stephen%3BKurc%2C+Tahsin%3BSanchez%2C+William%3BKher%2C+Manav%3BManisundaram%2C+Arumani%3BShanbhag%2C+Krishnakant%3BCovitz%2C+Peter&rft.aulast=Saltz&rft.aufirst=Joel&rft.date=2006-08-01&rft.volume=22&rft.issue=15&rft.spage=1910&rft.isbn=&rft.btitle=&rft.title=Bioinformatics&rft.issn=13674803&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cancer; Data processing; Bioinformatics; Information systems; Models; Computer programs; software; Heart; Computer applications ER - TY - JOUR T1 - The Anti-CD25 Monoclonal Antibody 7G7/B6, Armed with the alpha -Emitter super(211)At, Provides Effective Radioimmunotherapy for a Murine Model of Leukemia AN - 19465226; 7058872 AB - Radioimmunotherapy of cancer with radiolabeled antibodies has shown promise. alpha -Particles are very attractive for cancer therapy, especially for isolated malignant cells, as is observed in leukemia, because of their high linear energy transfer and short effective path length. We evaluated an anti-CD25 [interleukin-2 receptor alpha (IL-2R alpha )] monoclonal antibody, 7G7/B6, armed with super(211)At as a potential radioimmunotherapeutic agent for CD25-expressing leukemias and lymphomas. Therapeutic studies were done in severe combined immunodeficient/nonobese diabetic mice bearing the karpas299 leukemia and in nude mice bearing the SUDHL-1 lymphoma. The results from a pharmacokinetic study showed that the clearance of super(211)At-7G7/B6 from the circulation was virtually identical to super(125)I-7G7/B6. The biodistributions of super(211)At-7G7/B6 and super(125)I-7G7/B6 were also similar with the exception of a higher stomach uptake of radioactivity with super(211)At-7G7/B6. Therapy using 15 mu Ci of super(211)At-7G7/B6 prolonged survival of the karpas299 leukemia-bearing mice significantly when compared with untreated mice and mice treated with super(211)At-11F11, a radiolabeled nonspecific control antibody (P 70% of the mice in the super(211)At-7G7/B6 group still survived at that time. In summary, super(211)At-7G7/B6 could serve as an effective therapeutic agent for patients with CD25-expressing leukemias. (Cancer Res 2006; 66(16): 8227-32) JF - Cancer Research AU - Zhang, Meili AU - Yao, Zhengsheng AU - Zhang, Zhuo AU - Garmestani, Kayhan AU - Talanov, Vladimir S AU - Plascjak, Paul S AU - Yu, Sarah AU - Kim, Hyung-Sik AU - Goldman, Carolyn K AU - Paik, Chang H AU - Brechbiel, Martin W AU - Carrasquillo, Jorge A AU - Waldmann, Thomas A AD - Metabolism Branch and Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, and PET and Nuclear Medicine Department, Clinical Center, NIH, Bethesda, Maryland Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 8227 EP - 8232 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 66 IS - 16 SN - 0008-5472, 0008-5472 KW - Biotechnology and Bioengineering Abstracts KW - Interleukin 2 KW - Monoclonal antibodies KW - Animal models KW - Immunodeficiency KW - Survival KW - CD25 antigen KW - Pharmacokinetics KW - Interleukin 2 receptors KW - Cancer KW - Diabetes mellitus KW - Leukemia KW - Energy KW - Radioactivity KW - Lymphoma KW - Stomach KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19465226?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=The+Anti-CD25+Monoclonal+Antibody+7G7%2FB6%2C+Armed+with+the+alpha+-Emitter+super%28211%29At%2C+Provides+Effective+Radioimmunotherapy+for+a+Murine+Model+of+Leukemia&rft.au=Zhang%2C+Meili%3BYao%2C+Zhengsheng%3BZhang%2C+Zhuo%3BGarmestani%2C+Kayhan%3BTalanov%2C+Vladimir+S%3BPlascjak%2C+Paul+S%3BYu%2C+Sarah%3BKim%2C+Hyung-Sik%3BGoldman%2C+Carolyn+K%3BPaik%2C+Chang+H%3BBrechbiel%2C+Martin+W%3BCarrasquillo%2C+Jorge+A%3BWaldmann%2C+Thomas+A&rft.aulast=Zhang&rft.aufirst=Meili&rft.date=2006-08-01&rft.volume=66&rft.issue=16&rft.spage=8227&rft.isbn=&rft.btitle=&rft.title=Cancer+Research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Leukemia; Cancer; CD25 antigen; Monoclonal antibodies; Lymphoma; Immunodeficiency; Survival; Interleukin 2 receptors; Interleukin 2; Radioactivity; Animal models; Stomach; Pharmacokinetics; Diabetes mellitus; Energy ER - TY - JOUR T1 - Screening the receptorome: an efficient approach for drug discovery and target validation AN - 19456440; 7043006 AB - The receptorome, comprising at least 5% of the human genome, encodes receptors that mediate the physiological, pathological and therapeutic responses to a vast number of exogenous and endogenous ligands. Not surprisingly, the majority of approved medications target members of the receptorome. Several in silico and physical screening approaches have been devised to mine the receptorome efficiently for the discovery and validation of molecular targets for therapeutic drug discovery. Receptorome screening has also been used to discover, and thereby avoid, the molecular targets responsible for serious and unforeseen drug side effects. JF - Drug Discovery Today AU - Strachan, R T AU - Ferrara, G AU - Roth, B L AD - Neurosciences, Psychiatry and Oncology, Comprehensive Cancer Center and NIMH Psychoactive Drug Screening Program, Case Western Reserve University Medical School, Cleveland, OH 44106, USA, bryan.roth@case.edu Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 708 EP - 716 PB - Elsevier Ltd VL - 11 IS - 15-16 SN - 1359-6446, 1359-6446 KW - Biotechnology and Bioengineering Abstracts KW - Genomes KW - Drug discovery KW - Drugs KW - Side effects KW - W 30915:Pharmaceuticals & Vaccines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19456440?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Drug+Discovery+Today&rft.atitle=Screening+the+receptorome%3A+an+efficient+approach+for+drug+discovery+and+target+validation&rft.au=Strachan%2C+R+T%3BFerrara%2C+G%3BRoth%2C+B+L&rft.aulast=Strachan&rft.aufirst=R&rft.date=2006-08-01&rft.volume=11&rft.issue=15-16&rft.spage=708&rft.isbn=&rft.btitle=&rft.title=Drug+Discovery+Today&rft.issn=13596446&rft_id=info:doi/10.1016%2Fj.drudis.2006.06.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Drug discovery; Genomes; Side effects; Drugs DO - http://dx.doi.org/10.1016/j.drudis.2006.06.012 ER - TY - JOUR T1 - Modulatory role of cyclooxygenase-2 in cerebrovascular coupling AN - 19451994; 6985715 AB - To investigate the role of cyclooxygenase-2 (COX-2) in the cerebrovascular coupling, hemodynamic and neuronal responses to forepaw stimulation were measured in alpha -chloralose-anesthetized rats (N = 18) before and after intravenous administration of Meloxicam (MEL), a preferential COX-2 inhibitor, and following a bolus of prostaglandin E sub(2) (PGE sub(2)), a prominent vasodilatatory product of COX-2 catalyzed metabolism of arachidonic acid. The cerebral blood flow (CBF) and blood-oxygenation-level-dependent (BOLD) response was quantified using continuous arterial spin labeling magnetic resonance imaging. Neuronal activity was measured by recording somatosensory-evoked potentials (SEPs) via intracranial electrodes. Both MEL and PGE sub(2) had a significant effect on the activation-elicited CBF (P - 10 super(-6)) and BOLD (P - 10 super(-6)) responses, without affecting the baseline perfusion. Meloxicam decreased brain COX enzymatic activity by 57 +/- 14% and decreased the stimulation-induced CBF response to 32 +/- 2% and BOLD to 46 +/- 1% of their respective pre-drug amplitudes. In turn, PGE sub(2) bolus resulted in a partial recovery of functional hyperemia, with the CBF response recovering to 52 +/- 3% and the BOLD response to 56 +/- 2% of their values prior to MEL administration. There was no concomitant decrease in either amplitudes or latencies of SEP components. These findings suggest a modulatory role of COX-2 products in the cerebrovascular coupling and provide evidence for existence of a functional metabolic buffer. JF - NeuroImage AU - Stefanovic, Bojana AU - Bosetti, Francesca AU - Silva, Afonso C AD - Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Building 10, Room B1D109, Bethesda, MD 20892-1065, USA, stefanovicb@ninds.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 23 EP - 32 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 32 IS - 1 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Magnetic resonance imaging KW - Arachidonic acid KW - Hemodynamics KW - Recovery of function KW - Somatosensory evoked potentials KW - Enzymatic activity KW - Cyclooxygenase-2 KW - Intravenous administration KW - Perfusion KW - Brain KW - Prostaglandin E2 KW - hyperemia KW - meloxicam KW - Electrodes KW - Metabolism KW - Cerebral blood flow KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19451994?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Modulatory+role+of+cyclooxygenase-2+in+cerebrovascular+coupling&rft.au=Stefanovic%2C+Bojana%3BBosetti%2C+Francesca%3BSilva%2C+Afonso+C&rft.aulast=Stefanovic&rft.aufirst=Bojana&rft.date=2006-08-01&rft.volume=32&rft.issue=1&rft.spage=23&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.03.014 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Cyclooxygenase-2; Cerebral blood flow; Prostaglandin E2; Recovery of function; Somatosensory evoked potentials; meloxicam; Electrodes; Hemodynamics; Intravenous administration; Brain; Metabolism; hyperemia; Arachidonic acid; Enzymatic activity; Perfusion; Magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2006.03.014 ER - TY - JOUR T1 - Law and order: Assessing and enforcing compliance with ontological modeling principles in the Foundational Model of Anatomy AN - 19438926; 6860597 AB - The objective of this study is to provide an operational definition of principles with which well-formed ontologies should comply. We define 15 such principles, related to classification (e.g., no hierarchical cycles are allowed; concepts have a reasonable number of children), incompatible relationships (e.g., two concepts cannot stand both in a taxonomic and partitive relation), dependence among concepts, and the co-dependence of equivalent sets of relations. Implicit relations - embedded in concept names or inferred from a combination of explicit relations - are used in this process in addition to the relations explicitly represented. As a case study, we investigate the degree to which the Foundational Model of Anatomy (FMA) - a large ontology of anatomy - complies with these 15 principles. The FMA succeeds in complying with all the principles: totally with one and mostly with the others. Reasons for non- compliance are analyzed and suggestions are made for implementing effective enforcement mechanisms in ontology development environments. The limitations of this study are also discussed. JF - Computers in Biology and Medicine AU - Zhang, Songmao AU - Bodenreider, Olivier AD - U.S. National Library of Medicine, National Institutes of Health, Bethesda, MD, USA, smzhang@math.ac.cn Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 674 EP - 693 PB - Elsevier Science Ltd., Pergamon, P.O. Box 800 Kidlington Oxford OX5 1DX UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 36 IS - 7-8 SN - 0010-4825, 0010-4825 KW - Biotechnology and Bioengineering Abstracts KW - Classification KW - Computer applications KW - Children KW - Models KW - W 30960:Bioinformatics & Computer Applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19438926?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Computers+in+Biology+and+Medicine&rft.atitle=Law+and+order%3A+Assessing+and+enforcing+compliance+with+ontological+modeling+principles+in+the+Foundational+Model+of+Anatomy&rft.au=Zhang%2C+Songmao%3BBodenreider%2C+Olivier&rft.aulast=Zhang&rft.aufirst=Songmao&rft.date=2006-08-01&rft.volume=36&rft.issue=7-8&rft.spage=674&rft.isbn=&rft.btitle=&rft.title=Computers+in+Biology+and+Medicine&rft.issn=00104825&rft_id=info:doi/10.1016%2Fj.compbiomed.2005.04.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Models; Classification; Children; Computer applications DO - http://dx.doi.org/10.1016/j.compbiomed.2005.04.007 ER - TY - JOUR T1 - IL-10 Is Required for Optimal CD8 T Cell Memory following Listeria monocytogenes Infection AN - 19373642; 7132019 AB - IL-10 is an important immunoregulatory cytokine that plays a central role in maintaining a balance between protective immunity against infection and limiting proinflammatory responses to self or cross-reactive Ags. We examined the full effects of IL-10 deficiency on the establishment and quality of T cell memory using murine listeriosis as a model system. IL-10 super(-/-) mice had reduced bacterial loads and a shorter duration of primary infection than did wild-type mice. However, the number of Ag-specific T cells in secondary lymphoid and nonlymphoid organs was diminished in IL-10 super(-/-) mice, compared with wild-type mice, at the peak of the effector response. Moreover, the frequency and protective capacity of memory T cells also were reduced in IL-10 super(-/-) mice when assessed up to 100 days postinfection. Remarkably, this effect was more pronounced for CD8 T cells than CD4 T cells. To address whether differences in the number of bacteria and duration of primary infection could explain these findings, both strains of mice were treated with ampicillin 24 hours after primary infection. Despite there being more comparable bacterial loads during primary infection, IL-10 super(-/-) mice still generated fewer memory CD8 T cells and were less protected against secondary infection than were wild-type mice. Finally, the adoptive transfer of purified CD8 T cells from previously infected wild-type mice into naive recipients conferred better protection than the transfer of CD8 T cells from immune IL-10 super(-/-) mice. Overall, these data show that IL-10 plays an unexpected role in promoting and/or sustaining CD8 T cell memory following Listeria monocytogenes infection. JF - Journal of Immunology AU - Foulds, Kathryn E AU - Rotte, Masashi J AU - Seder, Robert A AD - Cellular Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2565 EP - 2574 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 4 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Listeria monocytogenes KW - Listeriosis KW - Animal models KW - Memory cells KW - Immunological memory KW - Ampicillin KW - Self KW - Secondary infection KW - CD8 antigen KW - Interleukin 10 KW - Inflammation KW - CD4 antigen KW - Adoptive transfer KW - Lymphocytes T KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19373642?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=IL-10+Is+Required+for+Optimal+CD8+T+Cell+Memory+following+Listeria+monocytogenes+Infection&rft.au=Foulds%2C+Kathryn+E%3BRotte%2C+Masashi+J%3BSeder%2C+Robert+A&rft.aulast=Foulds&rft.aufirst=Kathryn&rft.date=2006-08-01&rft.volume=177&rft.issue=4&rft.spage=2565&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Listeriosis; Immunological memory; Memory cells; Animal models; Self; Ampicillin; CD8 antigen; Secondary infection; Interleukin 10; Inflammation; CD4 antigen; Lymphocytes T; Adoptive transfer; Listeria monocytogenes ER - TY - JOUR T1 - Additional Conjugation Methods and Immunogenicity of Bacillus anthracis Poly- gamma -D-Glutamic Acid-Protein Conjugates AN - 19371141; 7128412 AB - The capsule of Bacillus anthracis, composed of poly- gamma -D-glutamic acid ( gamma DPGA), is an essential virulence factor of B. anthracis. The capsule inhibits innate host defense through its antiphagocytic action. gamma DPGA is a poor immunogen, but when covalently bound to a carrier protein, it elicits serum antibodies. To identify the optimal construct for clinical use, synthetic gamma DPGAs of different lengths were bound to carrier proteins at different densities. The advantages of the synthetic over the natural polypeptide are the homogeneous chain length and end groups, allowing conjugates to be accurately characterized and standardized and their chemical compositions to be related to their immunogenicities. In the present study, we evaluated, in addition to methods reported by us, hydrazone, oxime, and thioether linkages between gamma DPGA and several proteins, including bovine serum albumin, recombinant Pseudomonas aeruginosa exotoxin A, recombinant B. anthracis protective antigen (rPA), and tetanus toxoid (TT). The effects of the dosage and formulation on the immunogenicities of the conjugates were evaluated in mice. All conjugates were immunogenic. The optimal gamma DPGA chain length of 10 to 15 amino acids and the density, an average of 15 mol gamma DPGA per mol of protein, were confirmed. The thioether bond was the optimal linkage type, and TT and rPA were the best carriers. The optimal dosage was 1.2 to 2.5 mu g of gamma DPGA per mouse, and adsorption of the conjugates onto aluminum hydroxide significantly increased the antibody response to the protein with a lesser effect on anti- gamma DPGA levels. JF - Infection and Immunity AU - Kubler-Kielb, Joanna AU - Liu, Teh-Yung AU - Mocca, Christopher AU - Majadly, Fathy AU - Robbins, John B AU - Schneerson, Rachel AD - Laboratory of Developmental and Molecular Immunity, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 4744 EP - 4749 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Amino acids KW - virulence factors KW - protective antigen KW - Aluminum hydroxide KW - Antibody response KW - Toxoids KW - Bacillus anthracis KW - Tetanus KW - exotoxin A KW - thioethers KW - Bovine serum albumin KW - Immunogenicity KW - oximes KW - Adsorption KW - Pseudomonas aeruginosa KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19371141?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Additional+Conjugation+Methods+and+Immunogenicity+of+Bacillus+anthracis+Poly-+gamma+-D-Glutamic+Acid-Protein+Conjugates&rft.au=Kubler-Kielb%2C+Joanna%3BLiu%2C+Teh-Yung%3BMocca%2C+Christopher%3BMajadly%2C+Fathy%3BRobbins%2C+John+B%3BSchneerson%2C+Rachel&rft.aulast=Kubler-Kielb&rft.aufirst=Joanna&rft.date=2006-08-01&rft.volume=74&rft.issue=8&rft.spage=4744&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Amino acids; virulence factors; protective antigen; Aluminum hydroxide; Toxoids; Antibody response; Tetanus; exotoxin A; thioethers; Bovine serum albumin; Immunogenicity; oximes; Adsorption; Pseudomonas aeruginosa; Bacillus anthracis ER - TY - JOUR T1 - Construction and Characterization of an Attenuated Purine Auxotroph in a Francisella tularensis Live Vaccine Strain AN - 19366378; 7128381 AB - Francisella tularensis is a facultative intracellular pathogen and is the etiological agent of tularemia. It is capable of escaping from the phagosome, replicating to high numbers in the cytosol, and inducing apoptosis in macrophages of a variety of hosts. F. tularensis has received significant attention recently due to its potential use as a bioweapon. Currently, there is no licensed vaccine against F. tularensis, although a partially protective live vaccine strain (LVS) that is attenuated in humans but remains fully virulent for mice was previously developed. An F. tularensis LVS mutant deleted in the purMCD purine biosynthetic locus was constructed and partially characterized by using an allelic exchange strategy. The F. tularensis LVS Delta purMCD mutant was auxotrophic for purines when grown in defined medium and exhibited significant attenuation in virulence when assayed in murine macrophages in vitro or in BALB/c mice. Growth and virulence defects were complemented by the addition of the purine precursor hypoxanthine or by introduction of purMCDN in trans. The F. tularensis LVS Delta purMCD mutant escaped from the phagosome but failed to replicate in the cytosol or induce apoptotic and cytopathic responses in infected cells. Importantly, mice vaccinated with a low dose of the F. tularensis LVS Delta purMCD mutant were fully protected against subsequent lethal challenge with the LVS parental strain. Collectively, these results suggest that F. tularensis mutants deleted in the purMCD biosynthetic locus exhibit characteristics that may warrant further investigation of their use as potential live vaccine candidates. JF - Infection and Immunity AU - Pechous, Roger AU - Celli, Jean AU - Penoske, Renee AU - Hayes, Stanley F AU - Frank, Dara W AU - Zahrt, Thomas C AD - Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin 53226. Laboratory of Intracellular Parasites. Microscopy Core Unit, NIAID, National Institutes of Health, Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 4452 EP - 4461 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 8 SN - 0019-9567, 0019-9567 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Apoptosis KW - Auxotrophs KW - Phagosomes KW - Francisella tularensis KW - Pathogens KW - purines KW - Virulence KW - Tularemia KW - Cytosol KW - Hypoxanthine KW - Vaccines KW - F 06905:Vaccines KW - J 02350:Immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366378?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Construction+and+Characterization+of+an+Attenuated+Purine+Auxotroph+in+a+Francisella+tularensis+Live+Vaccine+Strain&rft.au=Pechous%2C+Roger%3BCelli%2C+Jean%3BPenoske%2C+Renee%3BHayes%2C+Stanley+F%3BFrank%2C+Dara+W%3BZahrt%2C+Thomas+C&rft.aulast=Pechous&rft.aufirst=Roger&rft.date=2006-08-01&rft.volume=74&rft.issue=8&rft.spage=4452&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Macrophages; Virulence; Tularemia; Apoptosis; Auxotrophs; Phagosomes; Hypoxanthine; Cytosol; Pathogens; Vaccines; purines; Francisella tularensis ER - TY - JOUR T1 - Adaptive response of Yersinia pestis to extracellular effectors of innate immunity during bubonic plague AN - 19365097; 7132680 AB - Yersinia pestis causes bubonic plague, characterized by an enlarged, painful lymph node, termed a bubo, that develops after bacterial dissemination from a fleabite site. In susceptible animals, the bacteria rapidly escape containment in the lymph node, spread systemically through the blood, and produce fatal sepsis. The fulminant progression of disease has been largely ascribed to the ability of Y. pestis to avoid phagocytosis and exposure to antimicrobial effectors of innate immunity. In vivo microarray analysis of Y. pestis gene expression, however, revealed an adaptive response to nitric oxide (NO)-derived reactive nitrogen species and to iron limitation in the extracellular environment of the bubo. Polymorphonuclear neutrophils recruited to the infected lymph node expressed abundant inducible NO synthase, and several Y. pestis homologs of genes involved in the protective response to reactive nitrogen species were up-regulated in the bubo. Mutation of one of these genes, which encodes the Hmp flavohemoglobin that detoxifies NO, attenuated virulence. Thus, the ability of Y. pestis to destroy immune cells and remain extracellular in the bubo appears to limit exposure to some but not all innate immune effectors. High NO levels induced during plague may also influence the developing adaptive immune response and contribute to septic shock. JF - Proceedings of the National Academy of Sciences, USA AU - Sebbane, Florent AU - Lemaitre, Nadine AU - Sturdevant, Daniel E AU - Rebeil, Roberto AU - Virtaneva, Kimmo AU - Porcella, Stephen F AU - Hinnebusch, BJoseph AD - Laboratory of Zoonotic Pathogens and Genomics Core Facility, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840 Y1 - 2006/08/01/ PY - 2006 DA - 2006 Aug 01 SP - 11766 EP - 11771 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 31 SN - 0027-8424, 0027-8424 KW - Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Leukocytes (polymorphonuclear) KW - Bubo KW - Yersinia pestis KW - reactive nitrogen species KW - Immunity KW - Septic shock KW - Lymph nodes KW - flavohemoglobin KW - Gene expression KW - Nitric-oxide synthase KW - Virulence KW - Blood KW - Sepsis KW - Nitric oxide KW - Immune response KW - Plague KW - Phagocytosis KW - Iron KW - Mutation KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19365097?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Adaptive+response+of+Yersinia+pestis+to+extracellular+effectors+of+innate+immunity+during+bubonic+plague&rft.au=Sebbane%2C+Florent%3BLemaitre%2C+Nadine%3BSturdevant%2C+Daniel+E%3BRebeil%2C+Roberto%3BVirtaneva%2C+Kimmo%3BPorcella%2C+Stephen+F%3BHinnebusch%2C+BJoseph&rft.aulast=Sebbane&rft.aufirst=Florent&rft.date=2006-08-01&rft.volume=103&rft.issue=31&rft.spage=11766&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Leukocytes (polymorphonuclear); reactive nitrogen species; Septic shock; Immunity; flavohemoglobin; Lymph nodes; Virulence; Nitric-oxide synthase; Gene expression; Blood; Sepsis; Nitric oxide; Plague; Immune response; Phagocytosis; Mutation; Iron; Yersinia pestis; Bubo ER - TY - JOUR T1 - Hemoglobin adducts in workers exposed to benzidine and azo dyes AN - 19364928; 7131032 AB - Benzidine (Bz) is a known human carcinogen. Several azo dyes have been synthesized with Bz. Bz can be metabolically released from azo dyes. In a group of Indian workers producing Bz and azo dyes the presence of hemoglobin (Hb) adducts was investigated. The following Hb adducts were identified and quantified by GC-MS: Bz, N-acetylbenzidine (AcBz), 4-aminobiphenyl (4ABP), aniline. 4ABP and aniline were quantitatively the major adducts. In the exposed workers (n = 33) all correlations between 4ABP, Bz and AcBz were r = 0.89 (P < 0.01) or greater. The group of workers exposed to Bz (Bz workers, n = 15) had 10-17-fold higher adduct levels than the workers exposed to dyes (dye workers, n = 18). 4ABP can be metabolically released from Bz and azo dyes. Aniline can be metabolically released from azo dyes. Therefore, the presence of 4ABP and aniline as Hb adducts is a consequence of exposure to the parent compounds or to the exposure of Bz and azo dyes and a consequent metabolical release of the arylamine moiety. The mean adduct ratios of 4ABP/(AcBz + Bz) varied up to 4-fold across all seven factories. Therefore, it is possible that 4ABP may have derived from general contamination in the work environment or endogenous metabolism, or a combination of the two. Since 4ABP is also a known human carcinogen, tumors observed in workers exposed to Bz or Bz dyes might be caused by both compounds. Further, these results suggest that understanding the role that genetic variants in NAT1 and NAT2 play in modifying the impact of Bz on bladder cancer risk may be complicated, as N-acetylation detoxifies 4ABP and activates Bz. JF - Carcinogenesis AU - Beyerbach, Armin AU - Rothman, Nathaniel AU - Bhatnagar, Vijai K AU - Kashyap, Rekha AU - Sabbioni, Gabriele AD - Institute of Environmental and Occupational Toxicology Casella Postale 108, CH-6780 Airolo, Switzerland. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services Bethesda, MD, 20892, USA. National Institute of Occupational Health Ahmedabad, India. Walther-Straub-Institut fuer Pharmakologie und Toxikologie, Ludwig-Maximilians-Universitaet Muenchen Nussbaumstrasse 26, 80336 Muenchen, Germany Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1600 EP - 1606 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 27 IS - 8 SN - 0143-3334, 0143-3334 KW - Toxicology Abstracts KW - N-Acetylbenzidine KW - Contamination KW - Azo dyes KW - Urinary bladder KW - Adducts KW - Tumors KW - Carcinogens KW - Cancer KW - Hemoglobin KW - Dyes KW - Carcinogenesis KW - Metabolism KW - Occupational exposure KW - Aniline KW - X 24350:Industrial Chemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19364928?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Carcinogenesis&rft.atitle=Hemoglobin+adducts+in+workers+exposed+to+benzidine+and+azo+dyes&rft.au=Beyerbach%2C+Armin%3BRothman%2C+Nathaniel%3BBhatnagar%2C+Vijai+K%3BKashyap%2C+Rekha%3BSabbioni%2C+Gabriele&rft.aulast=Beyerbach&rft.aufirst=Armin&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=Carcinogenesis&rft.issn=01433334&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - N-Acetylbenzidine; Contamination; Urinary bladder; Azo dyes; Adducts; Carcinogens; Tumors; Cancer; Hemoglobin; Dyes; Carcinogenesis; Occupational exposure; Metabolism; Aniline ER - TY - JOUR T1 - Analysis of secA1 Gene Sequences for Identification of Nocardia Species AN - 19362620; 7131836 AB - Molecular methodologies, especially 16S rRNA gene sequence analysis, have allowed the recognition of many new species of Nocardia and to date have been the most precise methods for identifying isolates reliably to the species level. We describe here a novel method for identifying Nocardia isolates by using sequence analysis of a portion of the secA1 gene. A region of the secA1 gene of 30 type or reference strains of Nocardia species was amplified using secA1-specific primers. Sequence analysis of 468 bp allowed clear differentiation of all species, with a range of interspecies similarity of 85.0% to 98.7%. Corresponding 16S rRNA gene sequences of a 1,285-bp region for the same isolates showed a range of interspecies similarity of 94.4 to 99.8%. In addition to the type and reference strains, a 468-bp fragment of the secA1 gene was sequenced from 40 clinical isolates of 12 Nocardia species previously identified by 16S rRNA gene sequence analysis. The secA1 gene sequences of most isolates showed >99.0% similarity to the secA1 sequences of the type or reference strain to which their identification corresponded, with a range of 95.3 to 100%. Comparison of the deduced 156 amino acid sequences of the SecA1 proteins of the clinical isolates showed between zero and two amino acid residue differences compared to that of the corresponding type or reference strain. Sequencing of the secA1 gene, and using deduced amino acid sequences of the SecA1 protein, may provide a more discriminative and precise method for the identification of Nocardia isolates than 16S rRNA gene sequencing. JF - Journal of Clinical Microbiology AU - Conville, Patricia S AU - Zelazny, Adrian M AU - Witebsky, Frank G AD - Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 2760 EP - 2766 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 44 IS - 8 SN - 0095-1137, 0095-1137 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Clinical isolates KW - Differentiation KW - Primers KW - Nocardia KW - rRNA 16S KW - New species KW - G 07770:Bacteria KW - J 02300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19362620?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Microbiology&rft.atitle=Analysis+of+secA1+Gene+Sequences+for+Identification+of+Nocardia+Species&rft.au=Conville%2C+Patricia+S%3BZelazny%2C+Adrian+M%3BWitebsky%2C+Frank+G&rft.aulast=Conville&rft.aufirst=Patricia&rft.date=2006-08-01&rft.volume=44&rft.issue=8&rft.spage=2760&rft.isbn=&rft.btitle=&rft.title=Journal+of+Clinical+Microbiology&rft.issn=00951137&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Clinical isolates; Differentiation; Primers; rRNA 16S; New species; Nocardia ER - TY - JOUR T1 - T-cell Control of IL-12p75 Production AN - 19338854; 6981116 AB - It is currently thought that IL-12, produced by dendritic cells (DC) early after stimulation by bacterial pathogens or lipopolysaccharide (LPS), acts as a pro-inflammatory cytokine bridging the innate and adaptive immune responses. We found, however, that it is only the p40 subunit and not the IL-12p75 heterodimer that is secreted early in copious amounts in response to LPS. Neither naive T cells, nor a variety of microbial products, were able to induce IL-12p75 production unless the DC were conditioned by the presence of interferon- gamma (IFN- gamma ) or by encounter with previously activated T cells. The inability of naive T cells or of bacterial products to induce IL-12 argues against its early role as the initiator of innate and adaptive immune responses. JF - Scandinavian Journal of Immunology AU - Abdi, K AU - Singh, N AU - Matzinger, P AD - Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA, kabdi@niaid.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 83 EP - 92 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 64 IS - 2 SN - 0300-9475, 0300-9475 KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts KW - Interleukin 12 KW - gamma -Interferon KW - Dendritic cells KW - Lymphocytes T KW - Lipopolysaccharides KW - Pathogens KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338854?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Scandinavian+Journal+of+Immunology&rft.atitle=T-cell+Control+of+IL-12p75+Production&rft.au=Abdi%2C+K%3BSingh%2C+N%3BMatzinger%2C+P&rft.aulast=Abdi&rft.aufirst=K&rft.date=2006-08-01&rft.volume=64&rft.issue=2&rft.spage=83&rft.isbn=&rft.btitle=&rft.title=Scandinavian+Journal+of+Immunology&rft.issn=03009475&rft_id=info:doi/10.1111%2Fj.1365-3083.2006.01767.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 3; references, 58. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Dendritic cells; gamma -Interferon; Interleukin 12; Lymphocytes T; Lipopolysaccharides; Pathogens DO - http://dx.doi.org/10.1111/j.1365-3083.2006.01767.x ER - TY - JOUR T1 - Surface-modulated motion switch: Capture and release of iron-sulfur protein in the cytochrome bc sub(1) complex AN - 19335618; 7064805 AB - In the cytochrome bc sub(1) complex, the swivel motion of the iron-sulfur protein (ISP) between two redox sites constitutes a key component of the mechanism that achieves the separation of the two electrons in a substrate molecule at the quinol oxidation (Q sub(o)) site. The question remaining is how the motion of ISP is controlled so that only one electron enters the thermodynamically favorable chain via ISP. An analysis of eight structures of mitochondrial bc sub(1) with bound Q sub(o) site inhibitors revealed that the presence of inhibitors causes a bidirectional repositioning of the cd1 helix in the cytochrome b subunit. As the cd1 helix forms a major part of the ISP binding crater, any positional shift of this helix modulates the ability of cytochrome b to bind ISP. The analysis also suggests a mechanism for reversal of the ISP fixation when the shape complementarity is significantly reduced after a positional reorientation of the reaction product quinone. The importance of shape complementarity in this mechanism was confirmed by functional studies of bc sub(1) mutants and by a structure determination of the bacterial form of bc sub(1). A mechanism for the high fidelity of the bifurcated electron transfer is proposed. JF - Proceedings of the National Academy of Sciences, USA AU - Esser, Lothar AU - Gong, Xing AU - Yang, Shaoqing AU - Yu, Linda AU - Yu, Chang-An AU - Xia, Di AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 13045 EP - 13050 PB - National Academy of Sciences, 2101 Constitution Ave. Washington DC 20418 USA VL - 103 IS - 35 SN - 0027-8424, 0027-8424 KW - Microbiology Abstracts B: Bacteriology KW - Cytochrome b KW - Fidelity KW - Cytochrome bc1 KW - quinol KW - Quinone KW - Oxidation KW - iron-sulfur proteins KW - Mitochondria KW - Electron transfer KW - Complementarity KW - J 02320:Cell Biology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19335618?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.atitle=Surface-modulated+motion+switch%3A+Capture+and+release+of+iron-sulfur+protein+in+the+cytochrome+bc+sub%281%29+complex&rft.au=Esser%2C+Lothar%3BGong%2C+Xing%3BYang%2C+Shaoqing%3BYu%2C+Linda%3BYu%2C+Chang-An%3BXia%2C+Di&rft.aulast=Esser&rft.aufirst=Lothar&rft.date=2006-08-01&rft.volume=103&rft.issue=35&rft.spage=13045&rft.isbn=&rft.btitle=&rft.title=Proceedings+of+the+National+Academy+of+Sciences%2C+USA&rft.issn=00278424&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cytochrome b; Fidelity; Cytochrome bc1; quinol; Oxidation; Quinone; iron-sulfur proteins; Mitochondria; Electron transfer; Complementarity ER - TY - JOUR T1 - Cancer Incidence among Pesticide Applicators Exposed to Cyanazine in the Agricultural Health Study AN - 19330456; 7070913 AB - Cyanazine is a common pesticide used frequently in the United States during the 1980s and 1990s. Animal and human studies have suggested that triazines may be carcinogenic, but results have been mixed. We evaluated cancer incidence in cyanazine-exposed pesticide applicators among the 57,311 licensed pesticide applicators in the Agricultural Health Study (AHS). We obtained detailed pesticide exposure information from a self-administered questionnaire completed at enrollment (1993-1997). Cancer incidence was followed through January 2002. Over half of cyanazine-exposed applicators had greater than or equal to 6 years of exposure at enrollment, and approximately 85% had begun using cyanazine before the 1990s. We used adjusted Poisson regression to calculate rate ratios (RRs) and 95% confidence intervals (CIs) of multiple cancer sites among cyanazine-exposed applicators. We calculated p sub(trend) values, and all statistical tests were two-sided. Two exposure metrics were used: tertiles of lifetime days of exposure (LD) and intensity-weighted LD. A total of 20,824 cancer-free AHS applicators reported ever using cyanazine at enrollment. Cancer incidence comparisons between applicators with the lowest cyanazine exposure and those with the highest exposure yielded the following for the LD metric: all cancers, RR = 0.99 (95% CI, 0.80-1.24); prostate cancer, RR = 1.23 (95% CI, 0.87-1.70); all lymphohematopoietic cancers, RR = 0.92 (95% CI, 0.50-1.72); non-Hodgkin lymphoma, RR = 1.25 (95% CI, 0.47-3.35); lung cancer, RR = 0.52 (95% CI, 0.22-1.25). We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. The number of sites was small for certain cancers, limiting any conclusion with regard to ovarian, breast, and some other cancers. JF - Environmental Health Perspectives AU - Lynch, S M AU - Rusiecki, JA AU - Blair, A AU - Dosemeci, M AU - Lubin, J AU - Sandler, D AU - Hoppin, JA AU - Lynch, C F AU - Alavanja, MCR AD - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 8000, Rockville, MD 20892, USA, alavanjm@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1248 EP - 1252 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - cyanazine KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Inventories KW - Breast KW - Statistical analysis KW - Agrochemicals KW - triazine KW - USA KW - Prostate cancer KW - Carcinogenicity KW - Pesticides KW - lymphoma KW - Lymphoma KW - Occupational exposure KW - Lung cancer KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19330456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Cancer+Incidence+among+Pesticide+Applicators+Exposed+to+Cyanazine+in+the+Agricultural+Health+Study&rft.au=Lynch%2C+S+M%3BRusiecki%2C+JA%3BBlair%2C+A%3BDosemeci%2C+M%3BLubin%2C+J%3BSandler%2C+D%3BHoppin%2C+JA%3BLynch%2C+C+F%3BAlavanja%2C+MCR&rft.aulast=Lynch&rft.aufirst=S&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1248&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8997 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Prostate cancer; Breast; Pesticides; Statistical analysis; Lymphoma; Lung cancer; triazine; Carcinogenicity; lymphoma; Agrochemicals; Occupational exposure; USA DO - http://dx.doi.org/10.1289/ehp.8997 ER - TY - JOUR T1 - Genomics update: Sampling of microbial diversity by complete genomes AN - 19326818; 6979028 JF - Environmental Microbiology AU - Galperin, Michael Y Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1313 EP - 1317 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 8 IS - 8 SN - 1462-2912, 1462-2912 KW - Microbiology Abstracts B: Bacteriology KW - genomics KW - Sampling KW - J 02310:Genetics & Taxonomy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19326818?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Microbiology&rft.atitle=Genomics+update%3A+Sampling+of+microbial+diversity+by+complete+genomes&rft.au=Galperin%2C+Michael+Y&rft.aulast=Galperin&rft.aufirst=Michael&rft.date=2006-08-01&rft.volume=8&rft.issue=8&rft.spage=1313&rft.isbn=&rft.btitle=&rft.title=Environmental+Microbiology&rft.issn=14622912&rft_id=info:doi/10.1111%2Fj.1462-2920.2006.01089.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Tables, 1; references, 30. N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Sampling; genomics DO - http://dx.doi.org/10.1111/j.1462-2920.2006.01089.x ER - TY - JOUR T1 - Phorate Exposure and Incidence of Cancer in the Agricultural Health Study AN - 19325204; 7070905 AB - We recently reported a link between use of the organophosphate pesticide phorate and risk of prostate cancer among applicators with a family history of prostate cancer in the Agricultural Health Study (AHS). This finding, together with findings of associations between other organophosphate pesticides and cancer more broadly, prompted us to examine phorate exposure and overall cancer incidence in the AHS. Adding 3 years of follow-up and using more detailed exposure information allowed us to see whether the prostate cancer finding held. The AHS is a prospective study of licensed restricted-use pesticide applicators from North Carolina and Iowa. To our knowledge, this is the largest examination of workers occupationally exposed to phorate. Pesticide exposure and other information was collected using two self-administered questionnaires completed from 1993 to 1997. Poisson regression was used to calculate rate ratios (RR) and 95% confidence intervals (CI), adjusting for potential confounders. Phorate use was not related to the incidence of all cancers combined or to any individual cancer, although we had insufficient numbers to study non-Hodgkin lymphoma or leukemia, which have been linked to organophosphates in other studies. Although prostate cancer risk was not significantly related to phorate use overall or among those without a family history, the risk tended to increase among applicators with a family history of prostate cancer. The interaction RR was 1.53 (95% CI, 0.99-2.37). The observed statistical interaction suggests a gene-environment interaction between family history and phorate exposure in the incidence of prostate cancer, but other explanations are also possible. JF - Environmental Health Perspectives AU - Mahajan, R AU - Bonner, M R AU - Hoppin, JA AU - Alavanja, MCR AD - 6120 Executive Blvd., EPS 8000, Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA, alavanjm@mail.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 1205 EP - 1209 VL - 114 IS - 8 SN - 0091-6765, 0091-6765 KW - phorate KW - Health & Safety Science Abstracts; Toxicology Abstracts; Risk Abstracts KW - Agriculture KW - USA, North Carolina KW - Historical account KW - Pesticides (organophosphorus) KW - Inventories KW - Statistics KW - Organophosphates KW - organophosphates KW - Cancer KW - Leukemia KW - Prostate cancer KW - USA, Iowa KW - Pesticides KW - lymphoma KW - Lymphoma KW - Occupational exposure KW - R2 23080:Industrial and labor KW - H 5000:Pesticides KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19325204?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Environmental+Health+Perspectives&rft.atitle=Phorate+Exposure+and+Incidence+of+Cancer+in+the+Agricultural+Health+Study&rft.au=Mahajan%2C+R%3BBonner%2C+M+R%3BHoppin%2C+JA%3BAlavanja%2C+MCR&rft.aulast=Mahajan&rft.aufirst=R&rft.date=2006-08-01&rft.volume=114&rft.issue=8&rft.spage=1205&rft.isbn=&rft.btitle=&rft.title=Environmental+Health+Perspectives&rft.issn=00916765&rft_id=info:doi/10.1289%2Fehp.8911 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Leukemia; Pesticides (organophosphorus); Statistics; Prostate cancer; phorate; organophosphates; Lymphoma; Occupational exposure; Agriculture; Historical account; Organophosphates; Pesticides; lymphoma; Cancer; USA, North Carolina; USA, Iowa DO - http://dx.doi.org/10.1289/ehp.8911 ER - TY - JOUR T1 - Quantum dot semiconductor nanocrystals for immunophenotyping by polychromatic flow cytometry AN - 19313917; 7046347 AB - Immune responses arise from a wide variety of cells expressing unique combinations of multiple cell-surface proteins. Detailed characterization is hampered, however, by limitations in available probes and instrumentation. Here we use the unique spectral properties of semiconductor nanocrystals (quantum dots) to extend the capabilities of polychromatic flow cytometry to resolve 17 fluorescence emissions. We show the need for this power by analyzing, in detail the phenotype of multiple antigen-specific T-cell populations, revealing variations within complex phenotypic patterns that would otherwise remain obscure. For example, T cells specific for distinct epitopes from one pathogen and even those specific for the same epitope, can have markedly different phenotypes. The technology we describe, encompassing the detection of eight quantum dots in conjunction with conventional fluorophores, should expand the horizons of flow cytometry, as well as our ability to characterize the intricacies of both adaptive and innate cellular immune responses. JF - Nature Medicine AU - Chattopadhyay, Pratip K AU - Price, David A AU - Harper, Theresa F AU - Betts, Michael R AU - Yu, Joanne AU - Gostick, Emma AU - Perfetto, Stephen P AU - Goepfert, Paul AU - Koup, Richard A AU - De Rosa, Stephen C AU - Bruchez, Marcel P AU - Roederer, Mario AD - Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, Maryland 20892, USA., Roederer@nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 972 EP - 977 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 12 IS - 8 SN - 1078-8956, 1078-8956 KW - Biotechnology and Bioengineering Abstracts; Immunology Abstracts; Bioengineering Abstracts KW - Flow cytometry KW - Fluorescence KW - Immune response (cell-mediated) KW - Lymphocytes T KW - Probes KW - fluorophores KW - Pathogens KW - Epitopes KW - F 06706:Cell-related methods KW - W4 130:General Biomedical Engineering: Tools & Techniques KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19313917?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Medicine&rft.atitle=Quantum+dot+semiconductor+nanocrystals+for+immunophenotyping+by+polychromatic+flow+cytometry&rft.au=Chattopadhyay%2C+Pratip+K%3BPrice%2C+David+A%3BHarper%2C+Theresa+F%3BBetts%2C+Michael+R%3BYu%2C+Joanne%3BGostick%2C+Emma%3BPerfetto%2C+Stephen+P%3BGoepfert%2C+Paul%3BKoup%2C+Richard+A%3BDe+Rosa%2C+Stephen+C%3BBruchez%2C+Marcel+P%3BRoederer%2C+Mario&rft.aulast=Chattopadhyay&rft.aufirst=Pratip&rft.date=2006-08-01&rft.volume=12&rft.issue=8&rft.spage=972&rft.isbn=&rft.btitle=&rft.title=Nature+Medicine&rft.issn=10788956&rft_id=info:doi/10.1038%2Fnm1371 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Flow cytometry; Immune response (cell-mediated); Fluorescence; Probes; Lymphocytes T; Pathogens; fluorophores; Epitopes DO - http://dx.doi.org/10.1038/nm1371 ER - TY - JOUR T1 - Why do B cells mutate their immunoglobulin receptors? AN - 19294918; 7042529 AB - B cells have the unique ability to acquire large numbers of point mutations in the variable segment of rearranged immunoglobulin (Ig) genes during a germinal center reaction. It is broadly accepted that somatic hypermutation (SHM) and affinity maturation are required to generate memory B cells and to produce antibodies capable of accomplishing the host defense functions of the humoral component of the adaptive immune system. However, several studies illustrate that low-avidity interactions between antigen and the B-cell receptor can induce deletion, receptor editing and a T-dependent immune response, suggesting that the high-avidity binding of antigen is not essential. If enhanced antigen binding is not essential for immune responses, what is the purpose of SHM? An alternative benefit of SHM might be to enhance the ability of B cells to track antigens expressed by rapidly mutating microorganisms. JF - Trends in Immunology AU - Longo, N S AU - Lipsky, P E Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 374 EP - 380 PB - Elsevier Ltd VL - 27 IS - 8 SN - 1471-4906, 1471-4906 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Immunology Abstracts KW - Deletion KW - Lymphocytes B KW - Point mutation KW - Immunological memory KW - Memory cells KW - Immunoglobulin receptors KW - Reviews KW - Microorganisms KW - somatic hypermutation KW - double prime B-cell receptor KW - Germinal centers KW - Immunoglobulins KW - A 01490:Miscellaneous KW - F 06624:B cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19294918?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+Immunology&rft.atitle=Why+do+B+cells+mutate+their+immunoglobulin+receptors%3F&rft.au=Longo%2C+N+S%3BLipsky%2C+P+E&rft.aulast=Longo&rft.aufirst=N&rft.date=2006-08-01&rft.volume=27&rft.issue=8&rft.spage=374&rft.isbn=&rft.btitle=&rft.title=Trends+in+Immunology&rft.issn=14714906&rft_id=info:doi/10.1016%2Fj.it.2006.06.007 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Deletion; Lymphocytes B; Reviews; Point mutation; Microorganisms; Memory cells; Immunological memory; somatic hypermutation; Germinal centers; double prime B-cell receptor; Immunoglobulin receptors; Immunoglobulins DO - http://dx.doi.org/10.1016/j.it.2006.06.007 ER - TY - JOUR T1 - Chlamydia trachomatis Causes Centrosomal Defects Resulting in Chromosomal Segregation Abnormalities AN - 19289343; 6981298 AB - Chlamydiae traffic along microtubules to the microtubule organizing center (MTOC) to establish an intracellular niche within the host cell. Trafficking to the MTOC is dynein dependent although the activating and cargo-linking function of the dynactin complex is supplanted by unknown chlamydial protein(s). We demonstrate that once localized to the MTOC, the chlamydial inclusion maintains a tight association with cellular centrosomes. This association is sustained through mitosis and leads to a significant increase in supernumerary centrosomes, abnormal spindle poles, and chromosomal segregation defects. Chlamydial infection thus can lead to chromosome instability in cells that recover from infection. JF - Traffic AU - Grieshaber, Scott S AU - Grieshaber, Nicole A AU - Miller, Natalie AU - Hackstadt, Ted AD - Ted Hackstadt, ted_hackstadt@nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 940 EP - 949 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 7 IS - 8 SN - 1398-9219, 1398-9219 KW - Microbiology Abstracts B: Bacteriology; Genetics Abstracts KW - Microtubules KW - Chromosomes KW - Spindles KW - Centrosomes KW - Mitosis KW - Chlamydia trachomatis KW - Dynein KW - Infection KW - dynactin KW - Supernumerary KW - J 02320:Cell Biology KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19289343?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Traffic&rft.atitle=Chlamydia+trachomatis+Causes+Centrosomal+Defects+Resulting+in+Chromosomal+Segregation+Abnormalities&rft.au=Grieshaber%2C+Scott+S%3BGrieshaber%2C+Nicole+A%3BMiller%2C+Natalie%3BHackstadt%2C+Ted&rft.aulast=Grieshaber&rft.aufirst=Scott&rft.date=2006-08-01&rft.volume=7&rft.issue=8&rft.spage=940&rft.isbn=&rft.btitle=&rft.title=Traffic&rft.issn=13989219&rft_id=info:doi/10.1111%2Fj.1600-0854.2006.00439.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-07-01 N1 - SuppNotes - Figures, 7; references, 47. N1 - Last updated - 2015-03-27 N1 - SubjectsTermNotLitGenreText - Spindles; Chromosomes; Microtubules; Mitosis; Centrosomes; Dynein; Infection; dynactin; Supernumerary; Chlamydia trachomatis DO - http://dx.doi.org/10.1111/j.1600-0854.2006.00439.x ER - TY - JOUR T1 - Polyclonal Long-Term MFGS-gp91phox Marking in Rhesus Macaques after Nonmyeloablative Transplantation with Transduced Autologous Peripheral Blood Progenitor Cells AN - 17237230; 6966811 AB - We have recently reported that the RD114-pseudotyped MFGS-gp91phox vector achieves unprecedented levels of correction of the NADPH-oxidase gp91phox (approved gene symbol CYBB) defect in CD34 super(+) cells from patients with X- linked chronic granulomatous disease in the NOD/SCID mouse model. Considering clinical use of this vector, we transplanted autologous mobilized peripheral blood CD34 super(+) progenitor cells, transduced with the RD114-MFGS-gp91phox vector, into two healthy rhesus macaques following nonmyeloablative conditioning. The moderately high levels of in vivo marking seen in the first months following transduction decreased and stabilized at about 8 months posttransplant. Marking for both healthy animals after 15 months was 0.3 to 1.3 vector copies per 100 cells in lymphocytes, neutrophils, and monocytes. Vector insertion analyses performed by linear amplification-mediated PCR and sequencing identified 32 and 45 separate insertion sites in the animals. Identical insertion sites were found in myeloid cells and lymphocytes, demonstrating the successful transduction of lymphomyeloid progenitors. Some inserts landed in the vicinity of genes controlling cell cycle and proliferation. Statistical analyses of insertion sites 1 year posttransplant suggest a high diversity of insertion sites despite low marking. JF - Molecular Therapy AU - Brenner, Sebastian AU - Ryser, Martin F AU - Choi, Uimook AU - Whiting-Theobald, Narda AU - Kuhlisch, Eberhard AU - Linton, Gilda AU - Kang, Elizabeth AU - Lehmann, Romy AU - Rosen-Wolff, Angela AU - Rudikoff, Andrew G AU - Farese, Ann M AU - MacVittie, Thomas J AU - Roesler, Joachim AU - Horwitz, Mitchell E AU - Malech, Harry L AD - Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA, sebastian.brenner@uniklinikum-dresden.de Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 202 EP - 211 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 2 SN - 1525-0016, 1525-0016 KW - Glycoprotein gp91 KW - NADPH oxidase KW - Rhesus monkey KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Autografts KW - Stem cells KW - Leukocytes (neutrophilic) KW - Hemopoiesis KW - Macaca mulatta KW - Peripheral blood KW - CD34 antigen KW - Severe combined immunodeficiency KW - Lymphocytes KW - Monocytes KW - Chronic granulomatous disease KW - W3 33170:Cellular based KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17237230?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Therapy&rft.atitle=Polyclonal+Long-Term+MFGS-gp91phox+Marking+in+Rhesus+Macaques+after+Nonmyeloablative+Transplantation+with+Transduced+Autologous+Peripheral+Blood+Progenitor+Cells&rft.au=Brenner%2C+Sebastian%3BRyser%2C+Martin+F%3BChoi%2C+Uimook%3BWhiting-Theobald%2C+Narda%3BKuhlisch%2C+Eberhard%3BLinton%2C+Gilda%3BKang%2C+Elizabeth%3BLehmann%2C+Romy%3BRosen-Wolff%2C+Angela%3BRudikoff%2C+Andrew+G%3BFarese%2C+Ann+M%3BMacVittie%2C+Thomas+J%3BRoesler%2C+Joachim%3BHorwitz%2C+Mitchell+E%3BMalech%2C+Harry+L&rft.aulast=Brenner&rft.aufirst=Sebastian&rft.date=2006-08-01&rft.volume=14&rft.issue=2&rft.spage=202&rft.isbn=&rft.btitle=&rft.title=Molecular+Therapy&rft.issn=15250016&rft_id=info:doi/10.1016%2Fj.ymthe.2006.01.015 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Autografts; Stem cells; Leukocytes (neutrophilic); Hemopoiesis; Severe combined immunodeficiency; CD34 antigen; Peripheral blood; Monocytes; Lymphocytes; Chronic granulomatous disease; Macaca mulatta DO - http://dx.doi.org/10.1016/j.ymthe.2006.01.015 ER - TY - JOUR T1 - Regiocontrolled synthesis and HIV inhibitory activity of unsymmetrical binaphthoquinone and trimeric naphthoquinone derivatives of conocurvone AN - 17226921; 6964591 AB - Unsymmetrical biquinone and trimeric quinone derivatives were synthesized using halotriflate-biselectrophilic naphthoquinones through stepwise regioselective quinone substitution chemistry and evaluated for their ability to inhibit the cytopathogenic effects of HIV-1 using an MTT colorimetric assay. Compounds were also screened for their ability to inhibit the activity of HIV-1 integrase in vitro. Pyranylated trimeric quinones and biquinones exhibited both antiviral activity and integrase inhibitory activity. Conocurvone 1 and trimeric quinone 21 were the most potent HIV integrase inhibitors in the series. All of the biquinones showed HIV inhibitory activity. Simple methoxy substituted biquinones did not inhibit HIV-1 integrase. JF - Bioorganic and Medicinal Chemistry AU - Stagliano, Kenneth W AU - Emadi, Ashkan AU - Lu, Zhenhai AU - Malinakova, Helena C AU - Twenter, Barry AU - Yu, Min AU - Holland, Louis E AU - Rom, Amanda M AU - Harwood, John S AU - Amin, Ronak AU - Johnson, Allison A AU - Pommier, Yves AD - Department of Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Chicago, IL 60616, USA, pommier@nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 5651 EP - 5665 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 14 IS - 16 SN - 0968-0896, 0968-0896 KW - HIV-1 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Virology & AIDS Abstracts KW - Quinone KW - Human immunodeficiency virus 1 KW - Colorimetry KW - Antiviral activity KW - Integrase KW - V 22002:AIDS: Molecular and in vitro aspects KW - W3 33372:Antiviral agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17226921?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Bioorganic+and+Medicinal+Chemistry&rft.atitle=Regiocontrolled+synthesis+and+HIV+inhibitory+activity+of+unsymmetrical+binaphthoquinone+and+trimeric+naphthoquinone+derivatives+of+conocurvone&rft.au=Stagliano%2C+Kenneth+W%3BEmadi%2C+Ashkan%3BLu%2C+Zhenhai%3BMalinakova%2C+Helena+C%3BTwenter%2C+Barry%3BYu%2C+Min%3BHolland%2C+Louis+E%3BRom%2C+Amanda+M%3BHarwood%2C+John+S%3BAmin%2C+Ronak%3BJohnson%2C+Allison+A%3BPommier%2C+Yves&rft.aulast=Stagliano&rft.aufirst=Kenneth&rft.date=2006-08-01&rft.volume=14&rft.issue=16&rft.spage=5651&rft.isbn=&rft.btitle=&rft.title=Bioorganic+and+Medicinal+Chemistry&rft.issn=09680896&rft_id=info:doi/10.1016%2Fj.bmc.2006.04.034 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Human immunodeficiency virus 1; Integrase; Quinone; Antiviral activity; Colorimetry DO - http://dx.doi.org/10.1016/j.bmc.2006.04.034 ER - TY - JOUR T1 - Plagues and adaptation: Lessons from the Felidae models for SARS and AIDS AN - 17193498; 6869098 AB - Research studies of infectious disease outbreaks in wild species of the cat family Felidae have revealed unusual details regarding forces that shape population survival and genetic resistance in these species. A highly virulent feline coronavirus epidemic in African cheetahs, a disease model for human SARS, illustrates the critical role of ancestral population genetic variation. Widespread prevalence of species specific feline immunodeficiency virus (FIV), a relative of HIV-AIDS, occurs with little pathogenesis in felid species, except in domestic cats, suggesting immunological adaptation in species where FIV is endemic. Resolving the interaction of host and pathogen genomes can shed new light on the process of disease outbreak in wildlife and in humankind. The role of disease in endangered populations and species is difficult to access as opportunities to monitor outbreaks in natural populations are limited. Conservation management may benefit greatly from advances in molecular genetic tools developed for human biomedical research to assay the biodiversity of both host species and emerging pathogen. As these examples illustrate, strong parallels exist between disease in human and endangered wildlife and argue for an integration of the research fields of comparative genomics, infectious disease, epidemiology, molecular genetics and population biology for an effective proactive conservation approach. JF - Biological Conservation AU - O'Brien, Stephen J AU - Troyer, Jennifer L AU - Roelke, Melody AU - Marker, Laurie AU - Pecon-Slattery, Jill AD - Laboratory of Genomic Diversity, National Cancer Institute, Building 560, Room 21-105, Frederick, MD 21702, USA, obrien@ncifcrf.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 255 EP - 267 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl] VL - 131 IS - 2 SN - 0006-3207, 0006-3207 KW - Cats KW - HIV KW - Sustainability Science Abstracts; Virology & AIDS Abstracts; Ecology Abstracts KW - FIV KW - SARS KW - AIDS KW - CDV KW - Acquired immune deficiency syndrome KW - Adaptations KW - Feline immunodeficiency virus KW - Wildlife KW - Pathogens KW - Feline coronavirus KW - Models KW - Population genetics KW - Felidae KW - Infectious diseases KW - Human immunodeficiency virus KW - Conservation KW - SARS coronavirus KW - V 22143:Epizootiology KW - M3 1010:Issues in Sustainable Development KW - D 04705:Conservation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17193498?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biological+Conservation&rft.atitle=Plagues+and+adaptation%3A+Lessons+from+the+Felidae+models+for+SARS+and+AIDS&rft.au=O%27Brien%2C+Stephen+J%3BTroyer%2C+Jennifer+L%3BRoelke%2C+Melody%3BMarker%2C+Laurie%3BPecon-Slattery%2C+Jill&rft.aulast=O%27Brien&rft.aufirst=Stephen&rft.date=2006-08-01&rft.volume=131&rft.issue=2&rft.spage=255&rft.isbn=&rft.btitle=&rft.title=Biological+Conservation&rft.issn=00063207&rft_id=info:doi/10.1016%2Fj.biocon.2006.05.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Population genetics; Acquired immune deficiency syndrome; Adaptations; Infectious diseases; Wildlife; Conservation; Pathogens; Models; Felidae; Human immunodeficiency virus; Feline immunodeficiency virus; SARS coronavirus; Feline coronavirus DO - http://dx.doi.org/10.1016/j.biocon.2006.05.001 ER - TY - JOUR T1 - Understanding recombinant expression of membrane proteins AN - 17044927; 7003405 AB - Over the past 15 years, numerous reports have been published on the recombinant expression of integral membrane proteins. Some proteins accumulate in the membrane to high levels, whereas other often closely related proteins are barely detected. Understanding the underlying reasons for this variation has proven difficult. Recent studies in this area have provided new insight into the response of host cells to membrane protein expression and into the mechanism of membrane insertion. The successful overproduction of some membrane proteins was shown to be linked to the avoidance of stress responses in the host cell. Furthermore, the cell response to membrane protein production has been quantified and several genes that are either upregulated or downregulated when yields of a membrane-inserted protein are poor were identified. Progress has also been made in understanding how the translocon, which is the site of protein translocation and membrane insertion, decides whether a protein segment is integrated into the membrane or not. Building upon such experiments will lead to targeted approaches for recombinant membrane protein expression. JF - Current Opinion in Biotechnology AU - Grisshammer, Reinhard AD - super(a)Laboratory of Molecular Biology of the National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA, rkgriss@helix.nih.gov Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - 337 EP - 340 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 17 IS - 4 SN - 0958-1669, 0958-1669 KW - Biotechnology and Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts; Agricultural and Environmental Biotechnology Abstracts KW - Protein transport KW - Protein biosynthesis KW - Reviews KW - Stress KW - Membrane proteins KW - W3 33340:Other proteins, peptides, amino acids KW - W2 32340:Other peptides, proteins, amino acids KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17044927?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Current+Opinion+in+Biotechnology&rft.atitle=Understanding+recombinant+expression+of+membrane+proteins&rft.au=Grisshammer%2C+Reinhard&rft.aulast=Grisshammer&rft.aufirst=Reinhard&rft.date=2006-08-01&rft.volume=17&rft.issue=4&rft.spage=337&rft.isbn=&rft.btitle=&rft.title=Current+Opinion+in+Biotechnology&rft.issn=09581669&rft_id=info:doi/10.1016%2Fj.copbio.2006.06.001 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Protein transport; Protein biosynthesis; Reviews; Stress; Membrane proteins DO - http://dx.doi.org/10.1016/j.copbio.2006.06.001 ER - TY - JOUR T1 - Chapter 27: Research needs following initial licensure of virus-like particle HPV vaccines AN - 1500776676; 19046192 AB - Human papillomavirus virus-like particle (HPV VLP) HPV vaccines currently evaluated for licensing are likely to be available soon. Licensure will be based on evidence that the vaccine is well tolerated and provides near complete type-specific protection against HPV infections and their resulting lesions in the first few years after vaccination. Several important questions will remain to be answered after licensure to guide vaccine implementation and to permit the rational evaluation of vaccination in cancer prevention programs. These include the long-term safety and efficacy of vaccination, the optimal ages for vaccination, efficacy against HPV types not included in the vaccine and against existing infections, and efficacy in males. Modulators of vaccine efficacy (e.g., HIV infection) and immune mechanisms of long-term protection also remain to be defined. The real-world effectiveness of vaccination programs will need to be assessed. Issues related to the implementation of a vaccine that targets pre-adolescents and early adolescents and to the acceptability of a cancer vaccine targeted against a sexually transmitted infection will need to be understood before vaccination programs can be successful. It is hoped that continued improvements to the current HPV vaccines will lead to the introduction in future years of second generation vaccines that simplify delivery and/or expand its coverage. Finally, the natural history of HPV types not covered in the candidate vaccines will need to be carefully studied following vaccination. Public health authorities in various countries will play a pivotal role in determining if these questions are answered in a timely manner. JF - Vaccine AU - Hildesheim, Allan AU - Markowitz, Lauri AU - Avila, Mauricio Hernandez AU - Franceschi, Silvia AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Room 7062, Rockville, MD, United States Bethesda, MD, United States Y1 - 2006/08// PY - 2006 DA - Aug 2006 SP - S227 EP - S232 PB - Elsevier B.V., The Boulevard Kidlington Oxford OX5 1GB United Kingdom VL - 24 SN - 0264-410X, 0264-410X KW - Virology & AIDS Abstracts; Health & Safety Science Abstracts; Immunology Abstracts KW - Historical account KW - Cancer vaccines KW - Age KW - Virus-like particles KW - Adolescence KW - Licensing KW - Acceptability KW - Particulates KW - Infection KW - Public health KW - Prevention KW - Infectious diseases KW - Human immunodeficiency virus KW - Lesions KW - Vaccines KW - Adolescents KW - Sexually transmitted diseases KW - Human papillomavirus KW - V 22360:AIDS and HIV KW - F 06910:Microorganisms & Parasites KW - H 4000:Food and Drugs UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/1500776676?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ahealthsafetyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Vaccine&rft.atitle=Chapter+27%3A+Research+needs+following+initial+licensure+of+virus-like+particle+HPV+vaccines&rft.au=Hildesheim%2C+Allan%3BMarkowitz%2C+Lauri%3BAvila%2C+Mauricio+Hernandez%3BFranceschi%2C+Silvia&rft.aulast=Hildesheim&rft.aufirst=Allan&rft.date=2006-08-01&rft.volume=24&rft.issue=&rft.spage=S227&rft.isbn=&rft.btitle=&rft.title=Vaccine&rft.issn=0264410X&rft_id=info:doi/10.1016%2Fj.vaccine.2006.05.102 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2014-02-01 N1 - Last updated - 2014-05-15 N1 - SubjectsTermNotLitGenreText - Cancer vaccines; Age; Virus-like particles; Adolescence; Infection; Public health; Historical account; Licensing; Acceptability; Particulates; Prevention; Infectious diseases; Human immunodeficiency virus; Lesions; Vaccines; Sexually transmitted diseases; Adolescents; Human papillomavirus DO - http://dx.doi.org/10.1016/j.vaccine.2006.05.102 ER - TY - CPAPER T1 - NCI Perspective on Clinical Trials for Emerging RT T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40220231; 4342223 JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Deye, J Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 KW - Clinical trials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40220231?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=NCI+Perspective+on+Clinical+Trials+for+Emerging+RT&rft.au=Deye%2C+J&rft.aulast=Deye&rft.aufirst=J&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Medical Physics Situation in Colombia T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40216897; 4342527 JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Machado, N AU - Plazas, M Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 KW - Colombia UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=Medical+Physics+Situation+in+Colombia&rft.au=Machado%2C+N%3BPlazas%2C+M&rft.aulast=Machado&rft.aufirst=N&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - High Accuracy of Volumetric Image Registration of CT, MR and PET Images T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40216877; 4342597 DE: JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Li, G. AU - Xie, H AU - Ning, H AU - Citrin, D AU - Capala, J AU - Arora, B AU - Coleman, C AU - Camphausen, K AU - Miller, R Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40216877?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=High+Accuracy+of+Volumetric+Image+Registration+of+CT%2C+MR+and+PET+Images&rft.au=Li%2C+G.%3BXie%2C+H%3BNing%2C+H%3BCitrin%2C+D%3BCapala%2C+J%3BArora%2C+B%3BColeman%2C+C%3BCamphausen%2C+K%3BMiller%2C+R&rft.aulast=Li&rft.aufirst=G.&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Pesudo-IMRT Method for Improving the Dose Uniformity in the Spine in Cranial-Spinal Irradaition T2 - 48th Annual Meeting of the American Association of Physicists in Medicine AN - 40205456; 4342786 JF - 48th Annual Meeting of the American Association of Physicists in Medicine AU - Ning, H AU - Chin, B AU - Karimpour, S AU - Li, G. AU - Xie, H AU - Miller, R Y1 - 2006/07/30/ PY - 2006 DA - 2006 Jul 30 KW - Spine UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40205456?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.atitle=A+Pesudo-IMRT+Method+for+Improving+the+Dose+Uniformity+in+the+Spine+in+Cranial-Spinal+Irradaition&rft.au=Ning%2C+H%3BChin%2C+B%3BKarimpour%2C+S%3BLi%2C+G.%3BXie%2C+H%3BMiller%2C+R&rft.aulast=Ning&rft.aufirst=H&rft.date=2006-07-30&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=48th+Annual+Meeting+of+the+American+Association+of+Physicists+in+Medicine&rft.issn=&rft_id=info:doi/ L2 - http://www.aapm.org/meetings/06AM/MeetingProgram.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Upregulation of the KIAA1199 gene is associated with cellular mortality. AN - 68604045; 16157444 AB - The microcell-mediated transfer of a normal human chromosome 3 induces replicative senescence in otherwise immortal renal cell carcinoma cells. To identify the genes involved in the chromosome 3-induced cellular mortality, we previously performed a cDNA subtraction experiment using the immortal renal cell carcinoma cells (RCC23) and the mortal counterpart with the transferred chromosome 3 (RCC23+3). We here report the cDNA cloning and characterization of one of the differentially expressed genes, which encodes KIAA1199 protein of unknown function. Northern blot and RT-PCR analyses revealed striking upregulation of KIAA1199 mRNA in mortal RCC23+3 compared with immortal RCC23. However, no significant change in KIAA1199 mRNA expression was observed during replicative aging in vitro (from early passage culture to senescent culture) of mortal human cells including RCC23+3, normal fibroblasts and prostate epithelial cells. Interestingly, an immortal fibroblast cell line and two breast cancer cell lines expressed much lower amounts of KIAA1199 mRNA than their normal counterparts. KIAA1199 mRNA is expressed in a wide range of normal human tissues, with the highest level of expression in brain. The gene is located on chromosome band 15q25, where a brain tumor suppressor gene has been mapped. These findings suggest that KIAA1199 gene may play a role in cellular mortality of normal human cells, which counters cell immortalization and carcinogenesis. JF - Cancer letters AU - Michishita, Eriko AU - Garcés, Giannina AU - Barrett, J Carl AU - Horikawa, Izumi AD - Laboratory of Biosystems and Cancer, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 9000 Rockville Pike, Bldg. 37, Rm. 5046, MSC-4264, Bethesda, MD 20892, USA. Y1 - 2006/07/28/ PY - 2006 DA - 2006 Jul 28 SP - 71 EP - 77 VL - 239 IS - 1 SN - 0304-3835, 0304-3835 KW - KIAA1199 protein, human KW - 0 KW - Proteins KW - RNA, Messenger KW - Index Medicus KW - Breast Neoplasms -- genetics KW - Humans KW - Chromosomes, Human, Pair 3 -- genetics KW - Prostatic Neoplasms -- genetics KW - Reverse Transcriptase Polymerase Chain Reaction KW - Cell Aging -- genetics KW - Fibroblasts -- metabolism KW - Tumor Cells, Cultured KW - RNA, Messenger -- metabolism KW - Gene Expression Regulation KW - Up-Regulation KW - Cell Division -- genetics KW - Cell Transformation, Neoplastic KW - Female KW - Male KW - Kidney Neoplasms -- genetics KW - Proteins -- genetics KW - Carcinoma, Renal Cell -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68604045?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+letters&rft.atitle=Upregulation+of+the+KIAA1199+gene+is+associated+with+cellular+mortality.&rft.au=Michishita%2C+Eriko%3BGarc%C3%A9s%2C+Giannina%3BBarrett%2C+J+Carl%3BHorikawa%2C+Izumi&rft.aulast=Michishita&rft.aufirst=Eriko&rft.date=2006-07-28&rft.volume=239&rft.issue=1&rft.spage=71&rft.isbn=&rft.btitle=&rft.title=Cancer+letters&rft.issn=03043835&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Subfertility in Female Estrogen Receptor-B Null Mice is Partially due to a Submaximal Luteinizing Hormone (LH) Surge T2 - 39th Annual Meeting of the Society for the Study of Reproduction AN - 40124517; 4302223 JF - 39th Annual Meeting of the Society for the Study of Reproduction AU - Jayes, Friederike L AU - Couse, John F AU - Korach, Kenneth S Y1 - 2006/07/28/ PY - 2006 DA - 2006 Jul 28 KW - Mice KW - Estrogen receptors KW - Hormones KW - Luteinizing hormone KW - Sex hormones KW - Surges UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124517?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+Meeting+of+the+Society+for+the+Study+of+Reproduction&rft.atitle=Subfertility+in+Female+Estrogen+Receptor-B+Null+Mice+is+Partially+due+to+a+Submaximal+Luteinizing+Hormone+%28LH%29+Surge&rft.au=Jayes%2C+Friederike+L%3BCouse%2C+John+F%3BKorach%2C+Kenneth+S&rft.aulast=Jayes&rft.aufirst=Friederike&rft.date=2006-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+Meeting+of+the+Society+for+the+Study+of+Reproduction&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={05B4BB4B-4B3A-44BC-9865-E 515806993D6} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Estrogen Receptor-B Facilitates Gonadotropin-Induced Cyclic-Amp Synthesis and Action in Granulosa Cells during Follicle Growth and Ovulation T2 - 39th Annual Meeting of the Society for the Study of Reproduction AN - 40050207; 4302590 JF - 39th Annual Meeting of the Society for the Study of Reproduction AU - Rodriguez, Karina F AU - Taniguchi, Fuminori AU - Couse, John F AU - Korach, Kenneth S Y1 - 2006/07/28/ PY - 2006 DA - 2006 Jul 28 KW - Estrogen receptors KW - Granulosa cells KW - Pituitary (anterior) KW - Ovulation KW - Follicles KW - Sex hormones KW - Growth UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40050207?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=39th+Annual+Meeting+of+the+Society+for+the+Study+of+Reproduction&rft.atitle=Estrogen+Receptor-B+Facilitates+Gonadotropin-Induced+Cyclic-Amp+Synthesis+and+Action+in+Granulosa+Cells+during+Follicle+Growth+and+Ovulation&rft.au=Rodriguez%2C+Karina+F%3BTaniguchi%2C+Fuminori%3BCouse%2C+John+F%3BKorach%2C+Kenneth+S&rft.aulast=Rodriguez&rft.aufirst=Karina&rft.date=2006-07-28&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=39th+Annual+Meeting+of+the+Society+for+the+Study+of+Reproduction&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey={05B4BB4B-4B3A-44BC-9865-E 515806993D6} LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2. AN - 68647904; 16846237 AB - The human ATP-binding cassette transporter, ABCG2, confers resistance to multiple chemotherapeutic agents and also affects the bioavailability of different drugs. [(125)I]Iodoarylazidoprazosin (IAAP) and [(3)H]azidopine were used for photoaffinity labeling of ABCG2 in this study. We show here for the first time that both of these photoaffinity analogues are transport substrates for ABCG2 and that [(3)H]azidopine can also be used to photolabel both wild-type R482-ABCG2 and mutant T482-ABCG2. We further used these assays to screen for potential substrates or modulators of ABCG2 and observed that 1,4-dihydropyridines such as nicardipine and nifedipine, which are clinically used as antihypertensive agents, inhibited the photolabeling of ABCG2 with [(125)I]IAAP and [(3)H]azidopine as well as the transport of these photoaffinity analogues by ABCG2. Furthermore, [(3)H]nitrendipine and bodipy-Fl-dihydropyridine accumulation assays showed that these compounds are transported by ABCG2. These dihydropyridines also inhibited the efflux of the known ABCG2 substrates, mitoxantrone and pheophorbide-a, from ABCG2-overexpressing cells, and nicardipine was more potent in inhibiting this transport. Both nicardipine and nifedipine stimulated the ATPase activity of ABCG2, and the nifedipine-stimulated activity was inhibited by fumitremorgin C, suggesting that these agents might interact at the same site on the transporter. In addition, nontoxic concentrations of dihydropyridines increased the sensitivity of ABCG2-expressing cells to mitoxantrone by 3-5-fold. In aggregate, results from the photoaffinity labeling and efflux assays using [(125)I]IAAP and [(3)H]azidopine demonstrate that 1,4-dihydropyridines are substrates of ABCG2 and that these photolabels can be used to screen new substrates and/or inhibitors of this transporter. JF - Biochemistry AU - Shukla, Suneet AU - Robey, Robert W AU - Bates, Susan E AU - Ambudkar, Suresh V AD - Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. Y1 - 2006/07/25/ PY - 2006 DA - 2006 Jul 25 SP - 8940 EP - 8951 VL - 45 IS - 29 SN - 0006-2960, 0006-2960 KW - ABCG2 protein, human KW - 0 KW - ATP Binding Cassette Transporter, Sub-Family G, Member 2 KW - Azides KW - Calcium Channel Blockers KW - Dihydropyridines KW - Neoplasm Proteins KW - Photoaffinity Labels KW - Chlorophyll KW - 1406-65-1 KW - 8-azidoadenosine 5'-triphosphate KW - 53696-59-6 KW - azidopine KW - 63XR70204A KW - Adenosine Triphosphate KW - 8L70Q75FXE KW - azidoprazosin KW - 90990-97-9 KW - Mitoxantrone KW - BZ114NVM5P KW - Nicardipine KW - CZ5312222S KW - Nifedipine KW - I9ZF7L6G2L KW - pheophorbide a KW - IA2WNI2HO2 KW - Prazosin KW - XM03YJ541D KW - Index Medicus KW - Drug Interactions KW - Chlorophyll -- metabolism KW - Mitoxantrone -- metabolism KW - Humans KW - Nicardipine -- metabolism KW - Nifedipine -- metabolism KW - Nicardipine -- pharmacology KW - Photoaffinity Labels -- metabolism KW - Adenosine Triphosphate -- analogs & derivatives KW - Adenosine Triphosphate -- metabolism KW - Chlorophyll -- analogs & derivatives KW - Cell Line KW - Prazosin -- metabolism KW - Azides -- metabolism KW - Dihydropyridines -- pharmacology KW - Prazosin -- analogs & derivatives KW - Calcium Channel Blockers -- metabolism KW - ATP-Binding Cassette Transporters -- metabolism KW - Prazosin -- pharmacology KW - Azides -- pharmacology KW - Dihydropyridines -- metabolism KW - Neoplasm Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68647904?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry&rft.atitle=The+calcium+channel+blockers%2C+1%2C4-dihydropyridines%2C+are+substrates+of+the+multidrug+resistance-linked+ABC+drug+transporter%2C+ABCG2.&rft.au=Shukla%2C+Suneet%3BRobey%2C+Robert+W%3BBates%2C+Susan+E%3BAmbudkar%2C+Suresh+V&rft.aulast=Shukla&rft.aufirst=Suneet&rft.date=2006-07-25&rft.volume=45&rft.issue=29&rft.spage=8940&rft.isbn=&rft.btitle=&rft.title=Biochemistry&rft.issn=00062960&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-07-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Bayesian Delta Error Value: A New Metric for Near Real-Time Error Detection. T2 - 2006 Annual Meeting and Clinical Lab Exposition of American Association for Clinical Chemistry (AACC 2006) AN - 40159421; 4317400 JF - 2006 Annual Meeting and Clinical Lab Exposition of American Association for Clinical Chemistry (AACC 2006) AU - Sampson, M L AU - Eberhardt, J S AU - Remaley, A T Y1 - 2006/07/23/ PY - 2006 DA - 2006 Jul 23 KW - Deltas KW - Bayesian analysis KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40159421?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Meeting+and+Clinical+Lab+Exposition+of+American+Association+for+Clinical+Chemistry+%28AACC+2006%29&rft.atitle=Bayesian+Delta+Error+Value%3A+A+New+Metric+for+Near+Real-Time+Error+Detection.&rft.au=Sampson%2C+M+L%3BEberhardt%2C+J+S%3BRemaley%2C+A+T&rft.aulast=Sampson&rft.aufirst=M&rft.date=2006-07-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Meeting+and+Clinical+Lab+Exposition+of+American+Association+for+Clinical+Chemistry+%28AACC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BFFEB1FEA%2DE733%2D491D% 2D9BFE%2DDBB1C5939B0A%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antifungal Activities of Essential Oil from Litsea Cubeba Pres. Fruits Against Wood Decay Fungi T2 - 2006 Annual Scientific Meeting of the Botanical Society of America (Botany 2006) AN - 39240101; 4235670 JF - 2006 Annual Scientific Meeting of the Botanical Society of America (Botany 2006) AU - Yen, Tsair-Bor AU - Hsieh, Chun-Chun Y1 - 2006/07/23/ PY - 2006 DA - 2006 Jul 23 KW - Decay KW - Fungi KW - Airborne microorganisms KW - Oil KW - Wood KW - Antifungal activity KW - Fruits KW - Decay fungi KW - Essential oils KW - Bioactive compounds KW - Litsea cubeba KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39240101?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Annual+Scientific+Meeting+of+the+Botanical+Society+of+America+%28Botany+2006%29&rft.atitle=Antifungal+Activities+of+Essential+Oil+from+Litsea+Cubeba+Pres.+Fruits+Against+Wood+Decay+Fungi&rft.au=Yen%2C+Tsair-Bor%3BHsieh%2C+Chun-Chun&rft.aulast=Yen&rft.aufirst=Tsair-Bor&rft.date=2006-07-23&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Annual+Scientific+Meeting+of+the+Botanical+Society+of+America+%28Botany+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.2006.botanyconference.org/engine/search/index.php?func=summ ary LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301. AN - 68650215; 16849749 AB - To provide bevacizumab (BV) -based therapy to patients with advanced colorectal cancers (CRC) who had exhausted standard chemotherapy options, and to evaluate the response to BV combined with fluorouracil (FU) and leucovorin (LV) in this patient population. This was a multicenter, single-arm treatment trial conducted under the National Cancer Institute Treatment Referral Center network nationwide. Patients were treated with BV 5 mg/kg every 2 weeks combined with FU/LV; FU was administered by bolus or continuous infusion. Eligibility criteria included advanced CRC that had progressed after irinotecan- and oxaliplatin-based chemotherapy, Eastern Cooperative Oncology Group performance status 0 to 2, and absence of thromboembolism. The primary end point was objective response rate (RR) in the first 100 assessable patients. All patients received follow-up for toxicity and survival. Due to rapid accrual, a total of 350 patients were enrolled at 32 participating sites nationwide by October 2003. In the initially planned cohort of 100 assessable patients, the objective RR was 4% (95% CI, 1.1% to 9.9%) by investigators' assessment and 1% (95% CI, 0% to 5.5%) based on independent review; median progression-free survival was 3.5 months and median overall survival was 9.0 months. The safety profile was similar to prior BV trials in CRC. Grade 3 to 4 hemorrhage occurred in 5% of patients, including 3.8% with bleeding in the GI tract. Other adverse events such as hypertension, thrombosis, and bowel perforation were also observed at rates consistent with other studies. For patients with advanced CRC that had progressed after both irinotecan-based and oxaliplatin-based chemotherapy regimens, the combination of BV and FU/LV was associated with rare objective responses. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Chen, Helen X AU - Mooney, Margaret AU - Boron, Matthew AU - Vena, Don AU - Mosby, Kimberly AU - Grochow, Louise AU - Jaffe, Carl AU - Rubinstein, Lawrence AU - Zwiebel, James AU - Kaplan, Richard S AD - Cancer Treatment Evaluation Program, National Cancer Institute, Bethesda, MD 20892, USA. Helen_Chen@nih.gov Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 SP - 3354 EP - 3360 VL - 24 IS - 21 KW - Angiogenesis Inhibitors KW - 0 KW - Antibodies, Monoclonal KW - Antibodies, Monoclonal, Humanized KW - Antimetabolites, Antineoplastic KW - Bevacizumab KW - 2S9ZZM9Q9V KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Index Medicus KW - United States KW - Antimetabolites, Antineoplastic -- administration & dosage KW - Disease-Free Survival KW - Leucovorin -- administration & dosage KW - Humans KW - Aged KW - Antibodies, Monoclonal -- administration & dosage KW - Angiogenesis Inhibitors -- administration & dosage KW - Fluorouracil -- administration & dosage KW - Aged, 80 and over KW - National Institutes of Health (U.S.) KW - Adult KW - Treatment Outcome KW - Middle Aged KW - Male KW - Female KW - Survival Analysis KW - Colorectal Neoplasms -- pathology KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68650215?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=Phase+II+multicenter+trial+of+bevacizumab+plus+fluorouracil+and+leucovorin+in+patients+with+advanced+refractory+colorectal+cancer%3A+an+NCI+Treatment+Referral+Center+Trial+TRC-0301.&rft.au=Chen%2C+Helen+X%3BMooney%2C+Margaret%3BBoron%2C+Matthew%3BVena%2C+Don%3BMosby%2C+Kimberly%3BGrochow%2C+Louise%3BJaffe%2C+Carl%3BRubinstein%2C+Lawrence%3BZwiebel%2C+James%3BKaplan%2C+Richard+S&rft.aulast=Chen&rft.aufirst=Helen&rft.date=2006-07-20&rft.volume=24&rft.issue=21&rft.spage=3354&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-09 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Clin Oncol. 2006 Jul 20;24(21):3325-7 [16849745] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Repression of HPV16 early region transcription by the E2 protein. AN - 68649009; 16624362 AB - HPV16 DNA is often integrated in cancers, disrupting the E1 or E2 genes. E2 can repress the E6/E7 promoter, but other models have been proposed to explain why integration promotes malignant progression. E1 and E2 are required for viral replication, and so genetic analysis of their role in transcriptional regulation is complex. Therefore, we developed an extrachromosomal vector containing HPV16 to undertake a genetic analysis of the E1 and E2 genes. We demonstrate that the E2 protein is primarily a transcriptional repressor when expressed from the virus. Furthermore, repression requires both the transactivation function of E2 and specific binding of E2 to the LCR. We find no evidence that the E1 protein directly modulates HPV16 gene expression. However, certain E1 mutations modulated transcription indirectly by altering splicing of E2 mRNA species. These data provide important insight into which E1 and E2 functions are optimal targets for anti-viral therapies. JF - Virology AU - Soeda, Emiko AU - Ferran, Maureen C AU - Baker, Carl C AU - McBride, Alison A AD - Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, MD 20892, USA. Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 SP - 29 EP - 41 VL - 351 IS - 1 SN - 0042-6822, 0042-6822 KW - DNA, Viral KW - 0 KW - DNA-Binding Proteins KW - E1 protein, Human papillomavirus 16 KW - E2 protein, Human papillomavirus type 16 KW - Oncogene Proteins, Viral KW - RNA, Viral KW - Repressor Proteins KW - Index Medicus KW - Virus Replication KW - Base Sequence KW - Open Reading Frames KW - Molecular Sequence Data KW - Herpesvirus 4, Human KW - Transcriptional Activation KW - Mutagenesis, Insertional KW - Human papillomavirus 16 -- metabolism KW - Gene Expression Regulation, Viral KW - Repressor Proteins -- metabolism KW - Transcription, Genetic KW - Human papillomavirus 16 -- genetics KW - Oncogene Proteins, Viral -- metabolism KW - DNA-Binding Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649009?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Virology&rft.atitle=Repression+of+HPV16+early+region+transcription+by+the+E2+protein.&rft.au=Soeda%2C+Emiko%3BFerran%2C+Maureen+C%3BBaker%2C+Carl+C%3BMcBride%2C+Alison+A&rft.aulast=Soeda&rft.aufirst=Emiko&rft.date=2006-07-20&rft.volume=351&rft.issue=1&rft.spage=29&rft.isbn=&rft.btitle=&rft.title=Virology&rft.issn=00426822&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-06 N1 - Date created - 2006-07-17 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - FIV Release Requires a PSAP Late Domain, TSG101, and ESCRT Machinery T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40156985; 4302181 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Luttge, B G AU - Shehu-Xhilaga, M AU - Freed, E O Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Feline immunodeficiency virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40156985?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=FIV+Release+Requires+a+PSAP+Late+Domain%2C+TSG101%2C+and+ESCRT+Machinery&rft.au=Luttge%2C+B+G%3BShehu-Xhilaga%2C+M%3BFreed%2C+E+O&rft.aulast=Luttge&rft.aufirst=B&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interactions between HIV-1 and HIV-2 Gag Polyproteins In Vivo T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40133261; 4302188 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Boyko, V P AU - Leavitt, M AU - Gorelick, R AU - Fu, W. AU - Nikolaitchik, O AU - Pathak, V K AU - Hu, W. Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Polyproteins KW - Human immunodeficiency virus 2 KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40133261?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Interactions+between+HIV-1+and+HIV-2+Gag+Polyproteins+In+Vivo&rft.au=Boyko%2C+V+P%3BLeavitt%2C+M%3BGorelick%2C+R%3BFu%2C+W.%3BNikolaitchik%2C+O%3BPathak%2C+V+K%3BHu%2C+W.&rft.aulast=Boyko&rft.aufirst=V&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Vif Counteracts a Cyclophilin Adependent Restriction of Simian Immunodeficiency Viruses in Human Cells T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40133156; 4302133 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Takeuchi, H AU - Strebel, K Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Viruses KW - Immunodeficiency KW - Peptidylprolyl isomerase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40133156?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Vif+Counteracts+a+Cyclophilin+Adependent+Restriction+of+Simian+Immunodeficiency+Viruses+in+Human+Cells&rft.au=Takeuchi%2C+H%3BStrebel%2C+K&rft.aulast=Takeuchi&rft.aufirst=H&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of Ubiquitination in Connecting HTLV-1 Assembly and Release with Components of the Multivesicular Body Biogenesis Pathway T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40132491; 4302179 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Heidecker, G Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Evolution KW - Ubiquitination KW - Biogenesis KW - Human T-lymphotropic virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132491?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=The+Role+of+Ubiquitination+in+Connecting+HTLV-1+Assembly+and+Release+with+Components+of+the+Multivesicular+Body+Biogenesis+Pathway&rft.au=Heidecker%2C+G&rft.aulast=Heidecker&rft.aufirst=G&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genomic Searches Identify Mucin and Others as Ligands for DC-SIGN T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40132392; 4302156 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Snyder, G Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Mucins KW - Genomics KW - DC-SIGN protein KW - Ligands UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40132392?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Genomic+Searches+Identify+Mucin+and+Others+as+Ligands+for+DC-SIGN&rft.au=Snyder%2C+G&rft.aulast=Snyder&rft.aufirst=G&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Development of Potent and Selective Inhibitors of HIV-1 Ribonuclease H T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40124746; 4302138 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Le Grice, S. AU - Beutler, J A Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Ribonuclease H KW - Inhibitors KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124746?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Development+of+Potent+and+Selective+Inhibitors+of+HIV-1+Ribonuclease+H&rft.au=Le+Grice%2C+S.%3BBeutler%2C+J+A&rft.aulast=Le+Grice&rft.aufirst=S.&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Antiviral Activity of Amphotericin B Methyl Ester (AME): Mechanism of Action and Isolation of AME-Resistant Mutants T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40124627; 4302124 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Waheed, A A AU - Freed, E O Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Esters KW - Mutants KW - Antiviral agents KW - Amphotericin B UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40124627?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Antiviral+Activity+of+Amphotericin+B+Methyl+Ester+%28AME%29%3A+Mechanism+of+Action+and+Isolation+of+AME-Resistant+Mutants&rft.au=Waheed%2C+A+A%3BFreed%2C+E+O&rft.aulast=Waheed&rft.aufirst=A&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Journey to the Center of the Cell: How HIV-1 CA Mutations Elude a Novel Cytoplasmic Restriction and Speed the Viral Genome to the Nucleus T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40093775; 4302136 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Ambrose, Z AU - Martin, T D AU - Lee, K AU - Baumann, J G AU - Julias, J G AU - Mulky, A AU - Takemura, T AU - Taniuchi, I AU - Hughes, S H AU - Unutmaz, D AU - KewalRamani, V N Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Mutation KW - Genomes KW - Nuclei KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40093775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Journey+to+the+Center+of+the+Cell%3A+How+HIV-1+CA+Mutations+Elude+a+Novel+Cytoplasmic+Restriction+and+Speed+the+Viral+Genome+to+the+Nucleus&rft.au=Ambrose%2C+Z%3BMartin%2C+T+D%3BLee%2C+K%3BBaumann%2C+J+G%3BJulias%2C+J+G%3BMulky%2C+A%3BTakemura%2C+T%3BTaniuchi%2C+I%3BHughes%2C+S+H%3BUnutmaz%2C+D%3BKewalRamani%2C+V+N&rft.aulast=Ambrose&rft.aufirst=Z&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Host Cell Machinery Involved in Host Cell Budding: Role of AIP1/ALIX T2 - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AN - 40055499; 4302182 JF - 2006 Meetings on Cell Biology of HIV-1 and Other Retroviruses AU - Munshi, U M AU - Ablan, S AU - Kim, J AU - Hurley, J H AU - Freed, E O Y1 - 2006/07/20/ PY - 2006 DA - 2006 Jul 20 KW - Budding UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40055499?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.atitle=Host+Cell+Machinery+Involved+in+Host+Cell+Budding%3A+Role+of+AIP1%2FALIX&rft.au=Munshi%2C+U+M%3BAblan%2C+S%3BKim%2C+J%3BHurley%2C+J+H%3BFreed%2C+E+O&rft.aulast=Munshi&rft.aufirst=U&rft.date=2006-07-20&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Meetings+on+Cell+Biology+of+HIV-1+and+Other+Retroviruses&rft.issn=&rft_id=info:doi/ L2 - http://www.ascb.org/meetings/summer06/atlanta/pdfs/program.pdf LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Crystal Structure of Mycobacterium tuberculosis Shikimate Kinase in Complex with Shikimic Acid and an ATP Analogue AN - 19464997; 7171831 AB - Shikimate kinase (SK) and other enzymes in the shikimate pathway are potential targets for developing nontoxic antimicrobial agents, herbicides, and antiparasite drugs, because the pathway is essential in microorganisms, plants, and parasites but absent from mammals. SK catalyzes the reaction of phosphoryl transfer from ATP to shikimic acid (SA). Since 2002, a total of 11 SK structures have been reported, but none contains either the two substrate (SA and ATP) or the two product (SA-phosphate and ADP) molecules. Here, we present three crystal structures of SK from Mycobacterium tuberculosis (MtSK), including apo-MtSK, a binary complex MtSK times SA, and the ternary complex of MtSK with SA and an ATP analogue, AMPPCP. The structures of apo-MtSK and MtSK times AMPPCP times SA make it possible to elucidate the conformational changes of MtSK upon the binding of both substrates; the structure of MtSK times AMPPCP times SA reveals interactions between the protein and gamma -phosphate which indicate dynamic roles of catalytic residues Lys15 and Arg117. JF - Biochemistry (Washington) AU - Gan, J AU - Gu, Y AU - Li, Y AU - Yan, H AU - Ji, X AD - Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland 21702, USA Y1 - 2006/07/18/ PY - 2006 DA - 2006 Jul 18 SP - 8539 EP - 8545 VL - 45 IS - 28 SN - 0006-2960, 0006-2960 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts B: Bacteriology KW - Parasites KW - shikimic acid KW - Crystal structure KW - Microorganisms KW - ATP KW - Enzymes KW - Herbicides KW - Shikimate kinase KW - Drugs KW - Mycobacterium tuberculosis KW - Antimicrobial agents KW - A 01340:Antibiotics & Antimicrobials KW - J 02330:Biochemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19464997?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Biochemistry+%28Washington%29&rft.atitle=Crystal+Structure+of+Mycobacterium+tuberculosis+Shikimate+Kinase+in+Complex+with+Shikimic+Acid+and+an+ATP+Analogue&rft.au=Gan%2C+J%3BGu%2C+Y%3BLi%2C+Y%3BYan%2C+H%3BJi%2C+X&rft.aulast=Gan&rft.aufirst=J&rft.date=2006-07-18&rft.volume=45&rft.issue=28&rft.spage=8539&rft.isbn=&rft.btitle=&rft.title=Biochemistry+%28Washington%29&rft.issn=00062960&rft_id=info:doi/10.1021%2Fbi0606290 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Parasites; shikimic acid; Microorganisms; Crystal structure; Enzymes; ATP; Herbicides; Shikimate kinase; Drugs; Antimicrobial agents; Mycobacterium tuberculosis DO - http://dx.doi.org/10.1021/bi0606290 ER - TY - JOUR T1 - Stability of substantia nigra pars reticulata neuronal discharge rates during dopamine receptor blockade and its possible mechanisms. AN - 68106143; 16791106 AB - It is hypothesized that substantia nigra pars reticulata neurons become overactive during a deficit of dopamine transmission. In this study, we examined how acute dopamine receptor blockade (SCH23390 and eticlopride) affects impulse activity of substantia nigra pars reticulata neurons and their response to iontophoretic gamma-amino-n-butyric acid in awake, unrestrained rats. No changes in discharge rate were found during complete dopamine receptor blockade, but these neurons showed a diminished response to gamma-amino-n-butyric acid, suggesting gamma-amino-n-butyric acid receptor hyposensitivity. This may result from tonic increase in gamma-amino-n-butyric acid input from the striatum and globus pallidus, which are activated during dopamine receptor blockade. As substantia nigra pars reticulata neurons are autoactive and resistant to tonic increases in gamma-amino-n-butyric acid input, changes in their responsiveness to phasic gamma-amino-n-butyric acid inputs, not tonic increase discharge rate, may underlie movement disturbance following dopamine deficit. JF - Neuroreport AU - Windels, François AU - Kiyatkin, Eugene A AD - Cellular Neurobiology Branch, National Institute on Drug Abuse - Intramural Research Program, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA. Y1 - 2006/07/17/ PY - 2006 DA - 2006 Jul 17 SP - 1071 EP - 1075 VL - 17 IS - 10 SN - 0959-4965, 0959-4965 KW - Benzazepines KW - 0 KW - Dopamine Antagonists KW - Receptors, Dopamine KW - Salicylamides KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - eticlopride KW - J8M468HBH4 KW - Index Medicus KW - Rats KW - Animals KW - Drug Interactions KW - Benzazepines -- pharmacology KW - Rats, Long-Evans KW - Dose-Response Relationship, Drug KW - gamma-Aminobutyric Acid -- pharmacology KW - Dopamine Antagonists -- pharmacology KW - Salicylamides -- pharmacology KW - Male KW - Action Potentials -- physiology KW - Receptors, Dopamine -- physiology KW - Neurons -- drug effects KW - Neurons -- physiology KW - Action Potentials -- drug effects KW - Substantia Nigra -- cytology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68106143?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuroreport&rft.atitle=Stability+of+substantia+nigra+pars+reticulata+neuronal+discharge+rates+during+dopamine+receptor+blockade+and+its+possible+mechanisms.&rft.au=Windels%2C+Fran%C3%A7ois%3BKiyatkin%2C+Eugene+A&rft.aulast=Windels&rft.aufirst=Fran%C3%A7ois&rft.date=2006-07-17&rft.volume=17&rft.issue=10&rft.spage=1071&rft.isbn=&rft.btitle=&rft.title=Neuroreport&rft.issn=09594965&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-08 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - New Developments at the NIH for Integration of Small-Molecule Databases and Bioinformatics Resources T2 - Fifth International Conference on Bioinformatics of Genome Regulation and Structure (BGRS 2006) AN - 40135619; 4301457 JF - Fifth International Conference on Bioinformatics of Genome Regulation and Structure (BGRS 2006) AU - Nicklaus, M Y1 - 2006/07/16/ PY - 2006 DA - 2006 Jul 16 KW - Integration KW - Databases KW - Bioinformatics KW - Resource development UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40135619?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=Fifth+International+Conference+on+Bioinformatics+of+Genome+Regulation+and+Structure+%28BGRS+2006%29&rft.atitle=New+Developments+at+the+NIH+for+Integration+of+Small-Molecule+Databases+and+Bioinformatics+Resources&rft.au=Nicklaus%2C+M&rft.aulast=Nicklaus&rft.aufirst=M&rft.date=2006-07-16&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=Fifth+International+Conference+on+Bioinformatics+of+Genome+Regulation+and+Structure+%28BGRS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.bionet.nsc.ru/meeting/bgrs2006/preliminary_program.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Differential effect of bryostatin 1 and phorbol 12-myristate 13-acetate on HOP-92 cell proliferation is mediated by down-regulation of protein kinase Cdelta. AN - 68649536; 16849575 AB - Bryostatin 1 is currently in clinical trials as a cancer chemotherapeutic agent. Although bryostatin 1, like phorbol 12-myristate 13-acetate (PMA), is a potent activator of protein kinase C (PKC), it induces only a subset of those responses induced by PMA and antagonizes others. We report that, in the HOP-92 non-small cell lung cancer line, bryostatin 1 induced a biphasic proliferative response, with maximal proliferation at 1 to 10 nmol/L. This biphasic response mirrored a biphasic suppression of the level of PKCdelta protein, with maximal suppression likewise at 1 to 10 nmol/L bryostatin 1. The typical phorbol ester PMA, in contrast to bryostatin 1, had no effect on the level of PKCdelta and modest suppression of cell proliferation, particularly evident at later treatment times. Flow cytometric analysis revealed changes in the fraction of cells in the G0-G1 and S phases corresponding to the effects on proliferation. Cells overexpressing PKCdelta exhibited a lower rate of cell proliferation compared with control untreated cells and showed neither a proliferative response nor a loss of PKCdelta in response to bryostatin 1. Conversely, treatment with PKCdelta small interfering RNA significantly increased the cellular growth compared with controls. We conclude that the differential effect on cellular proliferation induced by bryostatin 1 compared with PMA reflects the differential suppression of PKCdelta. JF - Cancer research AU - Choi, Sung Hee AU - Hyman, Tehila AU - Blumberg, Peter M AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 7261 EP - 7269 VL - 66 IS - 14 SN - 0008-5472, 0008-5472 KW - Bryostatins KW - 0 KW - Macrolides KW - bryostatin 1 KW - 37O2X55Y9E KW - Protein Kinase C-delta KW - EC 2.7.11.13 KW - Tetradecanoylphorbol Acetate KW - NI40JAQ945 KW - Index Medicus KW - Cell Growth Processes -- drug effects KW - Gene Expression Regulation, Enzymologic -- drug effects KW - Humans KW - Cell Line, Tumor KW - Down-Regulation -- drug effects KW - Gene Expression Regulation, Neoplastic -- drug effects KW - Lung Neoplasms -- enzymology KW - Macrolides -- pharmacology KW - Carcinoma, Non-Small-Cell Lung -- genetics KW - Lung Neoplasms -- drug therapy KW - Tetradecanoylphorbol Acetate -- pharmacology KW - Lung Neoplasms -- genetics KW - Carcinoma, Non-Small-Cell Lung -- enzymology KW - Carcinoma, Non-Small-Cell Lung -- drug therapy KW - Protein Kinase C-delta -- genetics KW - Protein Kinase C-delta -- biosynthesis KW - Lung Neoplasms -- pathology KW - Carcinoma, Non-Small-Cell Lung -- pathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649536?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Differential+effect+of+bryostatin+1+and+phorbol+12-myristate+13-acetate+on+HOP-92+cell+proliferation+is+mediated+by+down-regulation+of+protein+kinase+Cdelta.&rft.au=Choi%2C+Sung+Hee%3BHyman%2C+Tehila%3BBlumberg%2C+Peter+M&rft.aulast=Choi&rft.aufirst=Sung&rft.date=2006-07-15&rft.volume=66&rft.issue=14&rft.spage=7261&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells. AN - 68649505; 16849564 AB - Dysadherin, a cancer-associated membrane glycoprotein, down-regulates E-cadherin and promotes cancer metastasis. This study examined the role of dysadherin in breast cancer progression. Expression of dysadherin was found to be highest in breast cancer cell lines and tumors that lacked the estrogen receptor (ER). Knockdown of dysadherin caused increased association of E-cadherin with the actin cytoskeleton in breast cancer cell lines that expressed E-cadherin. However, knockdown of dysadherin could still suppress cell invasiveness in cells that had no functional E-cadherin, suggesting the existence of a novel mechanism of action. Global gene expression analysis identified chemokine (C-C motif) ligand 2 (CCL2) as the transcript most affected by dysadherin knockdown in MDA-MB-231 cells, and dysadherin was shown to regulate CCL2 expression in part through activation of the nuclear factor-kappaB pathway. The ability of dysadherin to promote tumor cell invasion in vitro was dependent on the establishment of a CCL2 autocrine loop, and CCL2 secreted by dysadherin-positive tumor cells also promoted endothelial cell migration in a paracrine fashion. Finally, experimental suppression of CCL2 in MDA-MB-231 cells reduced their ability to metastasize in vivo. This study shows that dysadherin has prometastatic effects that are independent of E-cadherin expression and that CCL2 could play an important role in mediating the prometastatic effect of dysadherin in ER-negative breast cancer. JF - Cancer research AU - Nam, Jeong-Seok AU - Kang, Mi-Jin AU - Suchar, Adam M AU - Shimamura, Takeshi AU - Kohn, Ethan A AU - Michalowska, Aleksandra M AU - Jordan, V Craig AU - Hirohashi, Setsuo AU - Wakefield, Lalage M AD - Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892-5055, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 7176 EP - 7184 VL - 66 IS - 14 SN - 0008-5472, 0008-5472 KW - Actins KW - 0 KW - CCL2 protein, human KW - Cadherins KW - Chemokine CCL2 KW - FXYD5 protein, human KW - Membrane Glycoproteins KW - NF-kappa B KW - Neoplasm Proteins KW - RNA, Small Interfering KW - Receptors, Estrogen KW - Index Medicus KW - Cadherins -- metabolism KW - Receptors, Estrogen -- biosynthesis KW - Humans KW - Actins -- metabolism KW - Cell Line, Tumor KW - RNA, Small Interfering -- genetics KW - Receptors, Estrogen -- metabolism KW - Transfection KW - Endothelial Cells -- cytology KW - Neoplasm Metastasis KW - Up-Regulation KW - Signal Transduction KW - Endothelial Cells -- metabolism KW - NF-kappa B -- metabolism KW - Breast Neoplasms -- genetics KW - Neoplasm Proteins -- biosynthesis KW - Membrane Glycoproteins -- biosynthesis KW - Breast Neoplasms -- pathology KW - Neoplasm Proteins -- genetics KW - Breast Neoplasms -- metabolism KW - Neoplasm Proteins -- metabolism KW - Chemokine CCL2 -- metabolism KW - Membrane Glycoproteins -- metabolism KW - Membrane Glycoproteins -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68649505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Chemokine+%28C-C+motif%29+ligand+2+mediates+the+prometastatic+effect+of+dysadherin+in+human+breast+cancer+cells.&rft.au=Nam%2C+Jeong-Seok%3BKang%2C+Mi-Jin%3BSuchar%2C+Adam+M%3BShimamura%2C+Takeshi%3BKohn%2C+Ethan+A%3BMichalowska%2C+Aleksandra+M%3BJordan%2C+V+Craig%3BHirohashi%2C+Setsuo%3BWakefield%2C+Lalage+M&rft.aulast=Nam&rft.aufirst=Jeong-Seok&rft.date=2006-07-15&rft.volume=66&rft.issue=14&rft.spage=7176&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Cancer Sci. 2005 Jul;96(7):379-86 [16053508] Int J Cancer. 2006 Jan 1;118(1):35-42 [16003740] J Biol Chem. 2005 Nov 11;280(45):37717-24 [16148001] Prostate. 2006 Feb 1;66(2):124-34 [16161154] Breast Cancer Res Treat. 2001 Jan;65(2):101-10 [11261825] Cancer. 2001 Sep 1;92(5):1085-91 [11571719] Nature. 2001 Mar 1;410(6824):50-6 [11242036] Clin Cancer Res. 2000 Aug;6(8):3282-9 [10955814] Blood. 2000 Jul 1;96(1):34-40 [10891427] Genomics. 2000 Aug 15;68(1):41-56 [10950925] Endocr Relat Cancer. 2005 Jul;12 Suppl 1:S37-46 [16113098] J Immunol. 2005 Oct 15;175(8):5370-8 [16210643] Int J Oncol. 2005 May;26(5):1429-34 [15809737] Lancet. 2005 Feb 19-25;365(9460):671-9 [15721472] J Biol Chem. 2001 Nov 9;276(45):42050-6 [11562372] Atherosclerosis. 2002 Jan;160(1):91-102 [11755926] Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):365-70 [11756660] Nature. 2002 Jan 31;415(6871):530-6 [11823860] Clin Cancer Res. 2002 Jul;8(7):2430-6 [12114449] N Engl J Med. 2002 Dec 19;347(25):1999-2009 [12490681] Sci STKE. 2003 Jan 21;2003(166):RE1 [12538882] J Clin Oncol. 2003 Feb 15;21(4):659-67 [12586803] Br J Cancer. 2003 Mar 10;88(5):726-32 [12618882] Int J Oncol. 2003 Apr;22(4):773-8 [12632067] Cancer Sci. 2003 Jul;94(7):575-81 [12841864] Biostatistics. 2003 Apr;4(2):249-64 [12925520] J Clin Endocrinol Metab. 2003 Sep;88(9):4407-12 [12970317] J Clin Invest. 2003 Oct;112(7):1116-24 [14523048] Cancer Res. 2003 Nov 1;63(21):7451-61 [14612545] Clin Exp Metastasis. 2003;20(8):723-31 [14713106] Clin Cancer Res. 2004 Mar 15;10(6):1901-10 [15041705] Clin Cancer Res. 2004 Apr 15;10(8):2818-23 [15102690] Crit Rev Oncol Hematol. 2004 Jul;51(1):55-67 [15207254] Nat Rev Cancer. 2004 Jul;4(7):540-50 [15229479] Semin Cancer Biol. 2004 Jun;14(3):149-54 [15246049] Cancer Cell. 2004 Jul;6(1):17-32 [15261139] Cancer Cell. 2004 Sep;6(3):203-8 [15380510] Cancer Res. 2004 Oct 1;64(19):6989-95 [15466191] Cancer Res. 1989 Apr 15;49(8):2128-33 [2702654] J Natl Cancer Inst. 1992 Apr 15;84(8):580-91 [1556769] Mol Cell Biol. 1993 Sep;13(9):5276-89 [8355682] J Cell Biol. 1994 Jun;125(6):1327-40 [8207061] J Immunol. 1994 Sep 1;153(5):2052-63 [8051410] Cancer Immunol Immunother. 1994 Oct;39(4):231-8 [7954525] Mol Med Today. 1996 May;2(5):198-204 [8796888] Mol Cell Biol. 1997 Mar;17(3):1503-12 [9032278] Int J Cancer. 1997 Apr 10;71(2):257-66 [9139852] J Biol Chem. 1997 Oct 3;272(40):25176-83 [9312130] Science. 1998 May 8;280(5365):898-902 [9572733] J Biol Chem. 1998 Jun 12;273(24):15249-56 [9614140] Atherosclerosis. 1999 Mar;143(1):205-11 [10208497] Appl Immunohistochem Mol Morphol. 2004 Dec;12(4):323-8 [15536331] Mod Pathol. 2005 Jan;18(1):26-35 [15332092] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. AN - 68648367; 16849569 AB - Cancers have been described as wounds that do not heal, suggesting that the two share common features. By comparing microarray data from a model of renal regeneration and repair (RRR) with reported gene expression in renal cell carcinoma (RCC), we asked whether those two processes do, in fact, share molecular features and regulatory mechanisms. The majority (77%) of the genes expressed in RRR and RCC were concordantly regulated, whereas only 23% were discordant (i.e., changed in opposite directions). The orchestrated processes of regeneration, involving cell proliferation and immune response, were reflected in the concordant genes. The discordant gene signature revealed processes (e.g., morphogenesis and glycolysis) and pathways (e.g., hypoxia-inducible factor and insulin-like growth factor-I) that reflect the intrinsic pathologic nature of RCC. This is the first study that compares gene expression patterns in RCC and RRR. It does so, in particular, with relation to the hypothesis that RCC resembles the wound healing processes seen in RRR. However, careful attention to the genes that are regulated in the discordant direction provides new insights into the critical differences between renal carcinogenesis and wound healing. The observations reported here provide a conceptual framework for further efforts to understand the biology and to develop more effective diagnostic biomarkers and therapeutic strategies for renal tumors and renal ischemia. JF - Cancer research AU - Riss, Joseph AU - Khanna, Chand AU - Koo, Seongjoon AU - Chandramouli, Gadisetti V R AU - Yang, Howard H AU - Hu, Ying AU - Kleiner, David E AU - Rosenwald, Andreas AU - Schaefer, Carl F AU - Ben-Sasson, Shmuel A AU - Yang, Liming AU - Powell, John AU - Kane, David W AU - Star, Robert A AU - Aprelikova, Olga AU - Bauer, Kristin AU - Vasselli, James R AU - Maranchie, Jodi K AU - Kohn, Kurt W AU - Buetow, Ken H AU - Linehan, W Marston AU - Weinstein, John N AU - Lee, Maxwell P AU - Klausner, Richard D AU - Barrett, J Carl AD - Laboratory of Biosystems and Cancer, Comparative Oncology Program, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA. rissjo@mail.nih.gov Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 7216 EP - 7224 VL - 66 IS - 14 SN - 0008-5472, 0008-5472 KW - Index Medicus KW - Animals KW - Oligonucleotide Array Sequence Analysis KW - Mice, Inbred C57BL KW - Gene Expression KW - Mice KW - Female KW - Kidney Neoplasms -- genetics KW - Carcinoma, Renal Cell -- pathology KW - Kidney Neoplasms -- pathology KW - Regeneration -- physiology KW - Kidney -- physiology KW - Carcinoma, Renal Cell -- genetics KW - Regeneration -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68648367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Cancers+as+wounds+that+do+not+heal%3A+differences+and+similarities+between+renal+regeneration%2Frepair+and+renal+cell+carcinoma.&rft.au=Riss%2C+Joseph%3BKhanna%2C+Chand%3BKoo%2C+Seongjoon%3BChandramouli%2C+Gadisetti+V+R%3BYang%2C+Howard+H%3BHu%2C+Ying%3BKleiner%2C+David+E%3BRosenwald%2C+Andreas%3BSchaefer%2C+Carl+F%3BBen-Sasson%2C+Shmuel+A%3BYang%2C+Liming%3BPowell%2C+John%3BKane%2C+David+W%3BStar%2C+Robert+A%3BAprelikova%2C+Olga%3BBauer%2C+Kristin%3BVasselli%2C+James+R%3BMaranchie%2C+Jodi+K%3BKohn%2C+Kurt+W%3BBuetow%2C+Ken+H%3BLinehan%2C+W+Marston%3BWeinstein%2C+John+N%3BLee%2C+Maxwell+P%3BKlausner%2C+Richard+D%3BBarrett%2C+J+Carl&rft.aulast=Riss&rft.aufirst=Joseph&rft.date=2006-07-15&rft.volume=66&rft.issue=14&rft.spage=7216&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. AN - 68646629; 16849582 AB - The proteasome inhibitor, bortezomib, and the histone deacetylase inhibitor, depsipeptide (FK228), up-regulate tumor death receptors. Therefore, we investigated whether pretreatment of malignant cells with these agents would potentiate natural killer (NK)-mediated tumor killing. NK cells isolated from healthy donors and patients with cancer were expanded in vitro and then tested for cytotoxicity against tumor cell lines before and after exposure to bortezomib or depsipeptide. In 11 of 13 (85%) renal cell carcinoma cell lines and in 16 of 37 (43%) other cancer cell lines, exposure to these drugs significantly increased NK cell-mediated tumor lysis compared with untreated tumor controls (P < 0.001). Furthermore, NK cells expanded from patients with metastatic renal cell carcinoma were significantly more cytotoxic against autologous tumor cells when pretreated with either bortezomib or depsipeptide compared with untreated tumors. Tumors sensitized to NK cell cytotoxicity showed a significant increase in surface expression of DR5 [tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-R2; P < 0.05]; in contrast, surface expression of MHC class I, MIC-A/B, DR4 (TRAIL-R1), and Fas (CD95) did not change. The enhanced susceptibility to NK cell killing was completely abolished by blocking TRAIL on NK cells, and partially abolished by blocking DR5 on tumor cells. These findings show that drug-induced sensitization to TRAIL could be used as a novel strategy to potentiate the anticancer effects of adoptively infused NK cells in patients with cancer. JF - Cancer research AU - Lundqvist, Andreas AU - Abrams, Scott I AU - Schrump, David S AU - Alvarez, Gauri AU - Suffredini, Dante AU - Berg, Maria AU - Childs, Richard AD - Hematology Branch, National Heart, Lung, and Blood Institute, Laboratory of Tumor Immunology and Biology, and Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-1202, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 7317 EP - 7325 VL - 66 IS - 14 SN - 0008-5472, 0008-5472 KW - Apoptosis Regulatory Proteins KW - 0 KW - Boronic Acids KW - Depsipeptides KW - Histone Deacetylase Inhibitors KW - Membrane Glycoproteins KW - Protease Inhibitors KW - Pyrazines KW - TNF-Related Apoptosis-Inducing Ligand KW - TNFSF10 protein, human KW - Tumor Necrosis Factor-alpha KW - Bortezomib KW - 69G8BD63PP KW - Index Medicus KW - Protease Inhibitors -- pharmacology KW - Cell Growth Processes -- drug effects KW - Protease Inhibitors -- administration & dosage KW - Cell Survival -- drug effects KW - Humans KW - Cell Line, Tumor KW - Drug Synergism KW - Boronic Acids -- pharmacology KW - Neoplasms -- drug therapy KW - Tumor Necrosis Factor-alpha -- administration & dosage KW - Tumor Necrosis Factor-alpha -- pharmacology KW - Pyrazines -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- pharmacology KW - Killer Cells, Natural -- drug effects KW - Membrane Glycoproteins -- administration & dosage KW - Apoptosis Regulatory Proteins -- pharmacology KW - Pyrazines -- administration & dosage KW - Boronic Acids -- administration & dosage KW - Depsipeptides -- pharmacology KW - Depsipeptides -- administration & dosage KW - Membrane Glycoproteins -- pharmacology KW - Apoptosis Regulatory Proteins -- administration & dosage KW - Killer Cells, Natural -- immunology KW - Neoplasms -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68646629?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Cancer+research&rft.atitle=Bortezomib+and+depsipeptide+sensitize+tumors+to+tumor+necrosis+factor-related+apoptosis-inducing+ligand%3A+a+novel+method+to+potentiate+natural+killer+cell+tumor+cytotoxicity.&rft.au=Lundqvist%2C+Andreas%3BAbrams%2C+Scott+I%3BSchrump%2C+David+S%3BAlvarez%2C+Gauri%3BSuffredini%2C+Dante%3BBerg%2C+Maria%3BChilds%2C+Richard&rft.aulast=Lundqvist&rft.aufirst=Andreas&rft.date=2006-07-15&rft.volume=66&rft.issue=14&rft.spage=7317&rft.isbn=&rft.btitle=&rft.title=Cancer+research&rft.issn=00085472&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-19 N1 - Date created - 2006-07-19 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Smoking and time to clearance of human papillomavirus infection in HIV-seropositive and HIV-seronegative women. AN - 68590554; 16775041 AB - Persistent human papillomavirus (HPV) infection seems central to cervical carcinogenesis. Smoking is associated with cervical cancer in HPV DNA-positive women, but its association with HPV persistence is unclear, particularly with respect to human immunodeficiency virus (HIV) serostatus. The authors evaluated smoking and HPV clearance by HIV serostatus among 801 women from the HIV Epidemiology Research Study (United States, 1993-2000). Type-specific HPV duration was defined as the interval between initial MY09/11 polymerase chain reaction positivity and the first of two consecutive HPV-negative study visits. Hazard ratios adjusted for study site and risk behaviors (sexual activity or injection drug use) were estimated using Cox regression. This analysis included 522 HIV-seropositive and 279 HIV-seronegative women (median follow-up, 4.4 years). Ever smoking was associated with reduced clearance of high-risk HPV in HIV-seronegative women (hazard ratio (HR) = 0.51, 95% confidence interval (CI): 0.30, 0.88) but not in HIV-seropositive women (HR = 0.96, 95% CI: 0.65, 1.42); similar results were found for current smoking. Current smoking was not associated with clearance of any type-specific HPV in HIV-seropositive (HR = 0.99, 95% CI: 0.82, 1.20) or HIV-seronegative (HR = 0.93, 95% CI: 0.68, 1.26) women. HPV clearance did not appear to vary by amount or duration of smoking. Smoking did not modify overall clearance but was associated with lower high-risk HPV clearance in HIV-seronegative women. JF - American journal of epidemiology AU - Koshiol, Jill AU - Schroeder, Jane AU - Jamieson, Denise J AU - Marshall, Stephen W AU - Duerr, Ann AU - Heilig, Charles M AU - Shah, Keerti V AU - Klein, Robert S AU - Cu-Uvin, Susan AU - Schuman, Paula AU - Celentano, David AU - Smith, Jennifer S AD - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA. koshiolj@mail.nih.gov Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 176 EP - 183 VL - 164 IS - 2 SN - 0002-9262, 0002-9262 KW - Index Medicus KW - Polymerase Chain Reaction KW - Risk Factors KW - Humans KW - Adult KW - United States -- epidemiology KW - Female KW - Proportional Hazards Models KW - Papillomavirus Infections -- epidemiology KW - HIV Seropositivity KW - Papillomaviridae -- isolation & purification KW - HIV Seronegativity KW - Smoking -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68590554?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=American+journal+of+epidemiology&rft.atitle=Smoking+and+time+to+clearance+of+human+papillomavirus+infection+in+HIV-seropositive+and+HIV-seronegative+women.&rft.au=Koshiol%2C+Jill%3BSchroeder%2C+Jane%3BJamieson%2C+Denise+J%3BMarshall%2C+Stephen+W%3BDuerr%2C+Ann%3BHeilig%2C+Charles+M%3BShah%2C+Keerti+V%3BKlein%2C+Robert+S%3BCu-Uvin%2C+Susan%3BSchuman%2C+Paula%3BCelentano%2C+David%3BSmith%2C+Jennifer+S&rft.aulast=Koshiol&rft.aufirst=Jill&rft.date=2006-07-15&rft.volume=164&rft.issue=2&rft.spage=176&rft.isbn=&rft.btitle=&rft.title=American+journal+of+epidemiology&rft.issn=00029262&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-10 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: a pilot study. AN - 68572237; 16730138 AB - Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis. The first 18 patients received 1 g of intrarectal amifostine suspension placed 30-45 min before each radiation treatment. The following 12 patients received 2 g of amifostine. Total dose prescribed ranged from 66 to 76 Gy. All patients were treated with three-dimensional conformal radiation therapy. The suspension remained intrarectal during treatment and was expelled after treatment. For gastrointestinal symptoms, during treatment and follow-up, all patients had a Radiation Therapy Oncology Group (RTOG) grade recorded. Median follow-up was 18 months (range, 6-24 months). With 2 g vs. 1 g amifostine, there was a nearly significant decrease in RTOG Grade 2 acute rectal toxicity. Seven weeks after the start of radiation therapy, the incidence of Grade 2 toxicity was 33% in the 1-g group (6/18) compared with 0% (0/12) in the 2-g group (p=0.06). No Grade 3 toxicity or greater occurred in this study. This trial suggests greater rectal radioprotection from acute effects with 2 g vs. 1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis. JF - International journal of radiation oncology, biology, physics AU - Singh, Anurag K AU - Ménard, Cynthia AU - Guion, Peter AU - Simone, Nicole L AU - Smith, Sharon AU - Crouse, Nancy Sears AU - Godette, Denise J AU - Cooley-Zgela, Theresa AU - Sciuto, Linda C AU - Coleman, Jonathan AU - Pinto, Peter AU - Albert, Paul S AU - Camphausen, Kevin AU - Coleman, C Norman AD - Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 1008 EP - 1013 VL - 65 IS - 4 SN - 0360-3016, 0360-3016 KW - Radiation-Protective Agents KW - 0 KW - Amifostine KW - M487QF2F4V KW - Index Medicus KW - Radiotherapy, Conformal KW - Humans KW - Aged KW - Pilot Projects KW - Administration, Rectal KW - Statistics, Nonparametric KW - Male KW - Radiation-Protective Agents -- administration & dosage KW - Radiation Injuries -- prevention & control KW - Rectum -- radiation effects KW - Proctitis -- prevention & control KW - Amifostine -- administration & dosage KW - Prostatic Neoplasms -- radiotherapy KW - Proctitis -- etiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572237?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.atitle=Intrarectal+amifostine+suspension+may+protect+against+acute+proctitis+during+radiation+therapy+for+prostate+cancer%3A+a+pilot+study.&rft.au=Singh%2C+Anurag+K%3BM%C3%A9nard%2C+Cynthia%3BGuion%2C+Peter%3BSimone%2C+Nicole+L%3BSmith%2C+Sharon%3BCrouse%2C+Nancy+Sears%3BGodette%2C+Denise+J%3BCooley-Zgela%2C+Theresa%3BSciuto%2C+Linda+C%3BColeman%2C+Jonathan%3BPinto%2C+Peter%3BAlbert%2C+Paul+S%3BCamphausen%2C+Kevin%3BColeman%2C+C+Norman&rft.aulast=Singh&rft.aufirst=Anurag&rft.date=2006-07-15&rft.volume=65&rft.issue=4&rft.spage=1008&rft.isbn=&rft.btitle=&rft.title=International+journal+of+radiation+oncology%2C+biology%2C+physics&rft.issn=03603016&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-07 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Genetic Characterization of Feline Calicivirus Strains Isolated in Missouri in 1995-96 T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40220281; 4339215 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Prikhodko, Victor AU - Ostlund, Eileen AU - Green, Kim AU - Sosnovtsev, Stanislav Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - USA, Missouri KW - Strains KW - Feline calicivirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40220281?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Genetic+Characterization+of+Feline+Calicivirus+Strains+Isolated+in+Missouri+in+1995-96&rft.au=Prikhodko%2C+Victor%3BOstlund%2C+Eileen%3BGreen%2C+Kim%3BSosnovtsev%2C+Stanislav&rft.aulast=Prikhodko&rft.aufirst=Victor&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - sCD4-17B: Increasing the Potency and Breadth of a Novel HIV-1 Neutralizing Protein T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40219358; 4339375 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Villarroel, Vadim AU - Avery, Carolyn AU - Jordan, Ayana AU - Lagenaur, Laurel AU - Berger, Edward Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Human immunodeficiency virus 1 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40219358?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=sCD4-17B%3A+Increasing+the+Potency+and+Breadth+of+a+Novel+HIV-1+Neutralizing+Protein&rft.au=Villarroel%2C+Vadim%3BAvery%2C+Carolyn%3BJordan%2C+Ayana%3BLagenaur%2C+Laurel%3BBerger%2C+Edward&rft.aulast=Villarroel&rft.aufirst=Vadim&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Sequence Variation among SA11 and SA11-4F Isolates T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40217539; 4339316 DE: JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Small, Catie AU - Brown, Thomas AU - Barro, Mario AU - Patton, John Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40217539?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Sequence+Variation+among+SA11+and+SA11-4F+Isolates&rft.au=Small%2C+Catie%3BBrown%2C+Thomas%3BBarro%2C+Mario%3BPatton%2C+John&rft.aulast=Small&rft.aufirst=Catie&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Enhanced Virulence of SARS-CoV Following Serial Passage in BALB/c Mice T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40217455; 4339227 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Vogel, Leatrice AU - Roberts, Anjeanette AU - Cheng, Aaron AU - Herman, Brian AU - Subbarao, Kanta Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Mice KW - Virulence KW - SARS coronavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40217455?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Enhanced+Virulence+of+SARS-CoV+Following+Serial+Passage+in+BALB%2Fc+Mice&rft.au=Vogel%2C+Leatrice%3BRoberts%2C+Anjeanette%3BCheng%2C+Aaron%3BHerman%2C+Brian%3BSubbarao%2C+Kanta&rft.aulast=Vogel&rft.aufirst=Leatrice&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Phenotypic and Molecular Alterations of Murine Rotavirus (EB Strain) Detected during Serial Passage in Mouse Pups or in Cell Cultures T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40209572; 4339479 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Tatsumi, Masatoshi AU - Hoshino, Yasutaka Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Cell culture KW - Pups KW - Phenotypes KW - Strains KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40209572?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Phenotypic+and+Molecular+Alterations+of+Murine+Rotavirus+%28EB+Strain%29+Detected+during+Serial+Passage+in+Mouse+Pups+or+in+Cell+Cultures&rft.au=Tatsumi%2C+Masatoshi%3BHoshino%2C+Yasutaka&rft.aulast=Tatsumi&rft.aufirst=Masatoshi&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Recognition of the Conserved 3_Squote_-End of Rotavirus (+)RNAs by the Viral RNA Polymerase T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40209210; 4339783 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Patton, John AU - Lu, Xiaohui AU - Tortorici, M Alejandra AU - Carpio, Rodrigo Vasquez-Del AU - Tao, Yizhi AU - Nibert, Max AU - Harrison, Stephen Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - DNA-directed RNA polymerase KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40209210?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Recognition+of+the+Conserved+3_Squote_-End+of+Rotavirus+%28%2B%29RNAs+by+the+Viral+RNA+Polymerase&rft.au=Patton%2C+John%3BLu%2C+Xiaohui%3BTortorici%2C+M+Alejandra%3BCarpio%2C+Rodrigo+Vasquez-Del%3BTao%2C+Yizhi%3BNibert%2C+Max%3BHarrison%2C+Stephen&rft.aulast=Patton&rft.aufirst=John&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cellular Secretory Pathway Components are Used in Poliovirus Replication T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40208745; 4339665 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Belov, George AU - Altan-Bonnet, Nihal AU - Ahmad-Khan, Sabiha AU - Lippincott-Schwartz, Jennifer AU - Ehrenfeld, Ellie Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Replication KW - Poliovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208745?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Cellular+Secretory+Pathway+Components+are+Used+in+Poliovirus+Replication&rft.au=Belov%2C+George%3BAltan-Bonnet%2C+Nihal%3BAhmad-Khan%2C+Sabiha%3BLippincott-Schwartz%2C+Jennifer%3BEhrenfeld%2C+Ellie&rft.aulast=Belov&rft.aufirst=George&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Comparative Analysis of the Infectivity of Full-Length Parvovirus B19 Genomic Clones T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40208616; 4339788 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Filippone, Claudia AU - Zhi, Ning AU - Lu, Jun AU - Wong, Susan AU - Kakkola, Laura AU - Soderlund-Venermo, Maria AU - Gallinella, Giorgio AU - Brown, Kevin E Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Infectivity KW - Genomics KW - Parvovirus B19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208616?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Comparative+Analysis+of+the+Infectivity+of+Full-Length+Parvovirus+B19+Genomic+Clones&rft.au=Filippone%2C+Claudia%3BZhi%2C+Ning%3BLu%2C+Jun%3BWong%2C+Susan%3BKakkola%2C+Laura%3BSoderlund-Venermo%2C+Maria%3BGallinella%2C+Giorgio%3BBrown%2C+Kevin+E&rft.aulast=Filippone&rft.aufirst=Claudia&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Koala RetrovirusUnraveling the Mystery Behind the Emergence of a Novel Gammaretrovirus Closely Related to Gibbon Ape Leukemia Virus T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40208166; 4339180 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Oliveira, Nidia AU - Satija, Harshita AU - Farrell, Karen AU - McKee, Jeff AU - Eiden, Maribeth Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Leukemia KW - Gibbon ape leukemia virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40208166?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Koala+RetrovirusUnraveling+the+Mystery+Behind+the+Emergence+of+a+Novel+Gammaretrovirus+Closely+Related+to+Gibbon+Ape+Leukemia+Virus&rft.au=Oliveira%2C+Nidia%3BSatija%2C+Harshita%3BFarrell%2C+Karen%3BMcKee%2C+Jeff%3BEiden%2C+Maribeth&rft.aulast=Oliveira&rft.aufirst=Nidia&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A New and Efficient Method for Culturing Parvovirus B19 using Purified Cd36 Cells T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40207367; 4339789 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Wong, Susan AU - Filippone, Claudia AU - Zhi, Ning AU - Brown, Kevin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - CD36 antigen KW - Parvovirus B19 UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40207367?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=A+New+and+Efficient+Method+for+Culturing+Parvovirus+B19+using+Purified+Cd36+Cells&rft.au=Wong%2C+Susan%3BFilippone%2C+Claudia%3BZhi%2C+Ning%3BBrown%2C+Kevin&rft.aulast=Wong&rft.aufirst=Susan&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Cytokine Analysis of Livers from Patients with Seronegative Viral Hepatitis T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40206728; 4339921 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Lu, Jun AU - Wong, Susan AU - Basu, Atanu AU - Young, Neal AU - Kevin, Kevin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Hepatitis KW - Liver KW - Cytokines UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40206728?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Cytokine+Analysis+of+Livers+from+Patients+with+Seronegative+Viral+Hepatitis&rft.au=Lu%2C+Jun%3BWong%2C+Susan%3BBasu%2C+Atanu%3BYoung%2C+Neal%3BKevin%2C+Kevin&rft.aulast=Lu&rft.aufirst=Jun&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Critical Role for a Viral RNA-Dependent RNA Polymerase in Antagonism of Host Interferon Responses T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40206188; 4339418 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Best, Sonja AU - Morris, Keely AU - Hallett, Rosie AU - Park, Gregory AU - Bloom, Marshall Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - RNA-directed RNA polymerase KW - Antagonism KW - Interferon KW - DNA-directed RNA polymerase UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40206188?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Critical+Role+for+a+Viral+RNA-Dependent+RNA+Polymerase+in+Antagonism+of+Host+Interferon+Responses&rft.au=Best%2C+Sonja%3BMorris%2C+Keely%3BHallett%2C+Rosie%3BPark%2C+Gregory%3BBloom%2C+Marshall&rft.aulast=Best&rft.aufirst=Sonja&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Disintegration of the Golgi Apparatus is a Mechanism of Viral Cytopathicity T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40205541; 4339724 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Freundt, Eric Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Golgi apparatus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40205541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Disintegration+of+the+Golgi+Apparatus+is+a+Mechanism+of+Viral+Cytopathicity&rft.au=Freundt%2C+Eric&rft.aulast=Freundt&rft.aufirst=Eric&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - A Novel Method of Infecting Ticks with a Tick-Borne Flavivirus T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40204505; 4339826 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Mitzel, V AU - Wolfinbarger, J AU - Best, S AU - Bloom, M Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Flavivirus KW - Ixodides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40204505?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=A+Novel+Method+of+Infecting+Ticks+with+a+Tick-Borne+Flavivirus&rft.au=Mitzel%2C+V%3BWolfinbarger%2C+J%3BBest%2C+S%3BBloom%2C+M&rft.aulast=Mitzel&rft.aufirst=V&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interferon Regulatory Factor 7 is Negatively Regulated by the Rotavirus Innate Immune Antagonist NSP1 T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40204179; 4339518 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Barro, Mario AU - Patton, John Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Interferon regulatory factor 7 KW - Rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40204179?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Interferon+Regulatory+Factor+7+is+Negatively+Regulated+by+the+Rotavirus+Innate+Immune+Antagonist+NSP1&rft.au=Barro%2C+Mario%3BPatton%2C+John&rft.aulast=Barro&rft.aufirst=Mario&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Detection and Partial Characterization of a Porcine Rotavirus Bearing an Aberrant Gene Stemming from an Intergenic Recombination of NSP2 Gene and NSP5 Gene T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40203024; 4339484 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Cao, Dianjun AU - Barro, Mario AU - Hoshino, Yasutaka Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Recombination KW - Porcine rotavirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40203024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Detection+and+Partial+Characterization+of+a+Porcine+Rotavirus+Bearing+an+Aberrant+Gene+Stemming+from+an+Intergenic+Recombination+of+NSP2+Gene+and+NSP5+Gene&rft.au=Cao%2C+Dianjun%3BBarro%2C+Mario%3BHoshino%2C+Yasutaka&rft.aulast=Cao&rft.aufirst=Dianjun&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Determination of Transcriptional Profile of a Novel Human Parvovirus (Parv4) T2 - 25th Annual Meeting of the American Society for Virology (ASV 2006) AN - 40200317; 4339790 JF - 25th Annual Meeting of the American Society for Virology (ASV 2006) AU - Zhi, Ning AU - Wong, Susan AU - Brown, Kevin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Transcription KW - Parvovirus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40200317?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.atitle=Determination+of+Transcriptional+Profile+of+a+Novel+Human+Parvovirus+%28Parv4%29&rft.au=Zhi%2C+Ning%3BWong%2C+Susan%3BBrown%2C+Kevin&rft.aulast=Zhi&rft.aufirst=Ning&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=25th+Annual+Meeting+of+the+American+Society+for+Virology+%28ASV+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://miracd.com/asv2006/Itinerary/SearchHome.asp LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Role of the TAU Gene in AD T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40186766; 4329072 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Hardy, John Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Tau protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40186766?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=The+Role+of+the+TAU+Gene+in+AD&rft.au=Hardy%2C+John&rft.aulast=Hardy&rft.aufirst=John&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Activation of Protein Kinase C Suppresses the b-Secretase Activity through Regulation of the Degradation and Translocation of BACE1 T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40179580; 4328954 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Wang, Lizheng AU - Shim, Hoon AU - Xie, Chengsong AU - Cai, Huaibin Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - B-Site APP cleaving enzyme 1 KW - Protein transport KW - Secretase KW - Protein kinase C UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40179580?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=Activation+of+Protein+Kinase+C+Suppresses+the+b-Secretase+Activity+through+Regulation+of+the+Degradation+and+Translocation+of+BACE1&rft.au=Wang%2C+Lizheng%3BShim%2C+Hoon%3BXie%2C+Chengsong%3BCai%2C+Huaibin&rft.aulast=Wang&rft.aufirst=Lizheng&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Relation between Retinal Microvascular Signs and Cerebral White Matter Lesions: The Ages-Reykjavik Study T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40174628; 4329480 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Qiu, Chengxuan AU - Cotch, Mary Frances AU - Sigurdson, Siggi AU - Klein, Ronald AU - Jonasson, Fridbert AU - Jonsson, Palmi V AU - Kjartansson, Olafur AU - Gudnason, Vilmundur AU - Launer, Lenore J Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Lesions KW - Substantia alba KW - Microvasculature KW - Retina UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40174628?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=Relation+between+Retinal+Microvascular+Signs+and+Cerebral+White+Matter+Lesions%3A+The+Ages-Reykjavik+Study&rft.au=Qiu%2C+Chengxuan%3BCotch%2C+Mary+Frances%3BSigurdson%2C+Siggi%3BKlein%2C+Ronald%3BJonasson%2C+Fridbert%3BJonsson%2C+Palmi+V%3BKjartansson%2C+Olafur%3BGudnason%2C+Vilmundur%3BLauner%2C+Lenore+J&rft.aulast=Qiu&rft.aufirst=Chengxuan&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The Infectious Unit of Prion Diseases and its Invasion of Neuronal Cells T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40174371; 4327976 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Caughey, Byron Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Prion protein UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40174371?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=The+Infectious+Unit+of+Prion+Diseases+and+its+Invasion+of+Neuronal+Cells&rft.au=Caughey%2C+Byron&rft.aulast=Caughey&rft.aufirst=Byron&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - The H1C Risk Haplotype of the Mapt Gene is Over-Expressed in Human Temporal Cortex Relative to the Other Common Alleles of Mapt T2 - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AN - 40174264; 4329443 JF - 10th International Coference on Alzheimer's Disease and Related Disorders (ICAD 2006) AU - Myers, Amanda J AU - Pittman, Alan M AU - Rohrer, Kristen AU - Zhao, Alice AU - Leung, Doris AU - Bryden, Leslie AU - Kaleem, Mona AU - Marlowe, Lauren AU - Fung, Chung AU - Lees, Andrew AU - Morris, Chris M AU - De Silva, Rohan AU - Hardy, John A Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 KW - Cortex (temporal) KW - Haplotypes KW - Allelles UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40174264?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.atitle=The+H1C+Risk+Haplotype+of+the+Mapt+Gene+is+Over-Expressed+in+Human+Temporal+Cortex+Relative+to+the+Other+Common+Alleles+of+Mapt&rft.au=Myers%2C+Amanda+J%3BPittman%2C+Alan+M%3BRohrer%2C+Kristen%3BZhao%2C+Alice%3BLeung%2C+Doris%3BBryden%2C+Leslie%3BKaleem%2C+Mona%3BMarlowe%2C+Lauren%3BFung%2C+Chung%3BLees%2C+Andrew%3BMorris%2C+Chris+M%3BDe+Silva%2C+Rohan%3BHardy%2C+John+A&rft.aulast=Myers&rft.aufirst=Amanda&rft.date=2006-07-15&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=10th+International+Coference+on+Alzheimer%27s+Disease+and+Related+Disorders+%28ICAD+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://abstractsonline.com/viewer/browseOptions.asp?MKey=%7B65136909%2 D91B3%2D4CC6%2DB889%2D7ACEB92BA9B6%7D&AKey=%7B50E1744A%2D0C52%2D45B2 %2DBF85%2D2A798BF24E02%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-21 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Major carcinogenic pathways identified by gene expression analysis of peritoneal mesotheliomas following chemical treatment in F344 rats AN - 19316972; 7043578 AB - This study was performed to characterize the gene expression profile and to identify the major carcinogenic pathways involved in rat peritoneal mesothelioma (RPM) formation following treatment of Fischer 344 rats with o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). Oligo arrays, with over 20,000 target genes, were used to evaluate o-NT- and BCA-induced RPMs, when compared to a non-transformed mesothelial cell line (Fred-PE). Analysis using Ingenuity Pathway Analysis software revealed 169 cancer-related genes that were categorized into binding activity, growth and proliferation, cell cycle progression, apoptosis, and invasion and metastasis. The microarray data were validated by positive correlation with quantitative real-time RT-PCR on 16 selected genes including igf1, tgfb3 and nov. Important carcinogenic pathways involved in RPM formation included insulin-like growth factor 1 (IGF-1), p38 MAPkinase, Wnt/ beta -catenin and integrin signaling pathways. This study demonstrated that mesotheliomas in rats exposed to o-NT- and BCA were similar to mesotheliomas in humans, at least at the cellular and molecular level. JF - Toxicology and Applied Pharmacology AU - Kim, Y AU - Ton, T V AU - DeAngelo, AB AU - Morgan, K AU - Devereux, T R AU - Anna, C AU - Collins, J B AU - Paules, R S AU - Crosby, L M AU - Sills, R C AD - National Institute of Environmental Health Sciences, MD B3-08, 111 Alexander Drive, Research Triangle Park, NC 27709, USA, sills@niehs.nih.gov Y1 - 2006/07/15/ PY - 2006 DA - 2006 Jul 15 SP - 144 EP - 151 VL - 214 IS - 2 SN - 0041-008X, 0041-008X KW - Genetics Abstracts; Toxicology Abstracts KW - Insulin-like growth factor I KW - Wnt protein KW - Apoptosis KW - Data processing KW - Cell cycle KW - Peritoneum KW - Metastases KW - Gene expression KW - Computer programs KW - software KW - catenin KW - Integrins KW - Insulin-like growth factors KW - mesothelioma KW - Polymerase chain reaction KW - Signal transduction KW - G 07730:Development & Cell Cycle KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19316972?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicology+and+Applied+Pharmacology&rft.atitle=Major+carcinogenic+pathways+identified+by+gene+expression+analysis+of+peritoneal+mesotheliomas+following+chemical+treatment+in+F344+rats&rft.au=Kim%2C+Y%3BTon%2C+T+V%3BDeAngelo%2C+AB%3BMorgan%2C+K%3BDevereux%2C+T+R%3BAnna%2C+C%3BCollins%2C+J+B%3BPaules%2C+R+S%3BCrosby%2C+L+M%3BSills%2C+R+C&rft.aulast=Kim&rft.aufirst=Y&rft.date=2006-07-15&rft.volume=214&rft.issue=2&rft.spage=144&rft.isbn=&rft.btitle=&rft.title=Toxicology+and+Applied+Pharmacology&rft.issn=0041008X&rft_id=info:doi/10.1016%2Fj.taap.2005.12.009 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Insulin-like growth factor I; Data processing; Apoptosis; Wnt protein; Peritoneum; Cell cycle; Gene expression; Metastases; Computer programs; software; catenin; Integrins; Insulin-like growth factors; Polymerase chain reaction; mesothelioma; Signal transduction DO - http://dx.doi.org/10.1016/j.taap.2005.12.009 ER - TY - JOUR T1 - Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. AN - 68639054; 16837598 AB - Emerging evidence suggests that alpha-synuclein (alpha-syn), which is traditionally thought to have a pathophysiological role in neurodegenerative diseases, can have neuroprotective effects. This study aimed to investigate whether endogenous alpha-syn in neurons can be induced by valproic acid (VPA), a mood-stabilizer, anticonvulsant and histone deacetylase (HDAC) inhibitor, and if so, whether the alpha-syn induction is neuroprotective. VPA treatment of rat cerebellar granule cells caused a robust dose- and time-dependent increase in levels of alpha-syn protein and mRNA and in the intensity of alpha-syn immunostaining. Knockdown of VPA-induced alpha-syn overexpression with alpha-syn antisense oligonucleotides or siRNA completely blocked VPA-induced neuroprotection. alpha-Syn knockdown also exacerbated glutamate neurotoxicity, stimulated the expression of the proapoptotic gene ubiquitin-conjugating enzyme E2N, and downregulated the expression of the anti-apoptotic gene Bcl-2. Induction of alpha-syn by VPA was associated with inhibition of HDAC activity, resulting in hyperacetylation of histone H3 in the alpha-syn promoter and a marked increase in alpha-syn promoter activity. Moreover, VPA-induced alpha-syn induction and neuroprotection were mimicked by HDAC inhibitors sodium 4-phenylbutyrate and trichostatin A (TSA). alpha-syn was also induced by VPA in rat cerebral cortical neurons. Additionally, treatment of rats with VPA, sodium butyrate, or TSA markedly increased alpha-syn protein levels in the cortex and cerebellum. Together, our results demonstrate for the first time that VPA induces alpha-syn in neurons through inhibition of HDAC and that this alpha-syn induction is critically involved in neuroprotection against glutamate excitotoxicity. Clinically, VPA may represent a suitable treatment for excitotoxicity-related neurodegenerative diseases. JF - The Journal of neuroscience : the official journal of the Society for Neuroscience AU - Leng, Yan AU - Chuang, De-Maw AD - Molecular Neurobiology Section, Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892-1363, USA. Y1 - 2006/07/12/ PY - 2006 DA - 2006 Jul 12 SP - 7502 EP - 7512 VL - 26 IS - 28 KW - Anticonvulsants KW - 0 KW - Antimanic Agents KW - Histone Deacetylase Inhibitors KW - Histones KW - Hydroxamic Acids KW - Neuroprotective Agents KW - Oligonucleotides, Antisense KW - Phenylbutyrates KW - Proto-Oncogene Proteins c-bcl-2 KW - RNA, Small Interfering KW - alpha-Synuclein KW - Glutamic Acid KW - 3KX376GY7L KW - trichostatin A KW - 3X2S926L3Z KW - Valproic Acid KW - 614OI1Z5WI KW - 4-phenylbutyric acid KW - 7WY7YBI87E KW - Ubiquitin-Conjugating Enzymes KW - EC 2.3.2.23 KW - Index Medicus KW - Proto-Oncogene Proteins c-bcl-2 -- biosynthesis KW - Animals KW - Cerebral Cortex -- cytology KW - Antimanic Agents -- pharmacology KW - Cerebral Cortex -- metabolism KW - Phenylbutyrates -- pharmacology KW - RNA, Small Interfering -- genetics KW - Oligonucleotides, Antisense -- pharmacology KW - Cerebellum -- metabolism KW - Rats KW - Acetylation KW - Anticonvulsants -- pharmacology KW - Rats, Sprague-Dawley KW - Promoter Regions, Genetic KW - Cerebellum -- cytology KW - Ubiquitin-Conjugating Enzymes -- biosynthesis KW - Cells, Cultured KW - Histones -- metabolism KW - Hydroxamic Acids -- pharmacology KW - Valproic Acid -- pharmacology KW - alpha-Synuclein -- biosynthesis KW - Glutamic Acid -- toxicity KW - Glutamic Acid -- metabolism KW - alpha-Synuclein -- genetics KW - Neuroprotective Agents -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68639054?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.atitle=Endogenous+alpha-synuclein+is+induced+by+valproic+acid+through+histone+deacetylase+inhibition+and+participates+in+neuroprotection+against+glutamate-induced+excitotoxicity.&rft.au=Leng%2C+Yan%3BChuang%2C+De-Maw&rft.aulast=Leng&rft.aufirst=Yan&rft.date=2006-07-12&rft.volume=26&rft.issue=28&rft.spage=7502&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+neuroscience+%3A+the+official+journal+of+the+Society+for+Neuroscience&rft.issn=1529-2401&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-21 N1 - Date created - 2006-07-13 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dendrimer-Based Nanoprobe for Dual Modality Magnetic Resonance and Fluorescence Imaging AN - 19458324; 7087027 AB - A novel PAMAM dendrimer-based nanoprobe for dual magnetic resonance and fluorescence imaging modalities was synthesized. Fluorescence studies revealed that Gd(III) complexation to the probe has no effect on the quantum yield; however, increases in the dye content resulted in partial quenching. The potential of the new nanoprobe, G6-(Cy5.5) sub(1.25)(1B4M-Gd) sub(145), as a dual modality imaging agent was demonstrated in vivo by the efficient visualization of sentinel lymph nodes in mice by both MRI and fluorescence imaging modalities. JF - Nano Letters AU - Talanov, V S AU - Regino, CAS AU - Kobayashi, Hisataka AU - Bernardo, M AU - Choyke, P L AU - Brechbiel, M W AD - Radiation Oncology Branch, Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1002, USA Y1 - 2006/07/12/ PY - 2006 DA - 2006 Jul 12 SP - 1459 EP - 1463 VL - 6 IS - 7 SN - 1530-6984, 1530-6984 KW - Biotechnology and Bioengineering Abstracts KW - Fluorescence KW - Magnetic resonance imaging KW - Fluorescent indicators KW - N.M.R. KW - Lymph nodes KW - W 30910:Imaging UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19458324?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nano+Letters&rft.atitle=Dendrimer-Based+Nanoprobe+for+Dual+Modality+Magnetic+Resonance+and+Fluorescence+Imaging&rft.au=Talanov%2C+V+S%3BRegino%2C+CAS%3BKobayashi%2C+Hisataka%3BBernardo%2C+M%3BChoyke%2C+P+L%3BBrechbiel%2C+M+W&rft.aulast=Talanov&rft.aufirst=V&rft.date=2006-07-12&rft.volume=6&rft.issue=7&rft.spage=1459&rft.isbn=&rft.btitle=&rft.title=Nano+Letters&rft.issn=15306984&rft_id=info:doi/10.1021%2Fnl060765q LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Fluorescence; N.M.R.; Magnetic resonance imaging; Fluorescent indicators; Lymph nodes DO - http://dx.doi.org/10.1021/nl060765q ER - TY - JOUR T1 - Neuroprotective agents for clinical trials in ALS: a systematic assessment. AN - 68629609; 16832072 AB - Riluzole is currently the only Food and Drug Administration-approved treatment for ALS, but its effect on survival is modest. To identify potential neuroprotective agents for testing in phase III clinical trials and to outline which data need to be collected for each drug. The authors identified 113 compounds by inviting input from academic clinicians and researchers and via literature review to identify agents that have been tested in ALS animal models and in patients with ALS. The list was initially narrowed to 24 agents based on an evaluation of scientific rationale, toxicity, and efficacy in previous animal and human studies. These 24 drugs underwent more detailed pharmacologic evaluation. Twenty drugs were selected as suitable for further development as treatments for patients with ALS. Talampanel and tamoxifen have completed early phase II trials and have demonstrated preliminary efficacy. Other agents (ceftriaxone, minocycline, ONO-2506, and IGF-1 polypeptide) are already in phase III trials involving large numbers of patients with ALS. Remaining agents (AEOL 10150, arimoclomol, celastrol, coenzyme Q10, copaxone, IGF-1-viral delivery, memantine, NAALADase inhibitors, nimesulide, scriptaid, sodium phenylbutyrate, thalidomide, trehalose) require additional preclinical animal data, human toxicity and pharmacokinetic data including CNS penetration prior to proceeding to large scale phase III human testing. Further development of riluzole analogues should be considered. Several potential neuroprotective compounds, representing a wide range of mechanisms, are available and merit further investigation in ALS. JF - Neurology AU - Traynor, B J AU - Bruijn, L AU - Conwit, R AU - Beal, F AU - O'Neill, G AU - Fagan, S C AU - Cudkowicz, M E AD - Neurology Clinical Trials Unit, Department of Neurology, Massachusetts General Hospital, Boston, USA. traynorb@mail.nih.gov Y1 - 2006/07/11/ PY - 2006 DA - 2006 Jul 11 SP - 20 EP - 27 VL - 67 IS - 1 KW - Neuroprotective Agents KW - 0 KW - Abridged Index Medicus KW - Index Medicus KW - Evaluation Studies as Topic KW - Humans KW - Outcome Assessment (Health Care) KW - Neuroprotective Agents -- therapeutic use KW - Clinical Trials as Topic -- methods KW - Amyotrophic Lateral Sclerosis -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68629609?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neurology&rft.atitle=Neuroprotective+agents+for+clinical+trials+in+ALS%3A+a+systematic+assessment.&rft.au=Traynor%2C+B+J%3BBruijn%2C+L%3BConwit%2C+R%3BBeal%2C+F%3BO%27Neill%2C+G%3BFagan%2C+S+C%3BCudkowicz%2C+M+E&rft.aulast=Traynor&rft.aufirst=B&rft.date=2006-07-11&rft.volume=67&rft.issue=1&rft.spage=20&rft.isbn=&rft.btitle=&rft.title=Neurology&rft.issn=1526-632X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-08 N1 - Date created - 2006-07-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: Neurology. 2007 Feb 27;68(9):709; author reply 710 [17325287] N1 - Last updated - 2017-01-18 ER - TY - CPAPER T1 - Dietary Fatty Acids may Modulate Processes Implicated in AMD Pathogenesis T2 - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AN - 40261681; 4374665 JF - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AU - SanGiovanni, J AU - Chew, E Y AU - Tsai, J.-Y. AU - Lee, L B AU - Jaworski, C AU - Connor, K AU - Smith, L E AU - Salem, N AU - Carper, D Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Fatty acids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40261681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.atitle=Dietary+Fatty+Acids+may+Modulate+Processes+Implicated+in+AMD+Pathogenesis&rft.au=SanGiovanni%2C+J%3BChew%2C+E+Y%3BTsai%2C+J.-Y.%3BLee%2C+L+B%3BJaworski%2C+C%3BConnor%2C+K%3BSmith%2C+L+E%3BSalem%2C+N%3BCarper%2C+D&rft.aulast=SanGiovanni&rft.aufirst=J&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BC02D51F4%2D1802%2D420E% 2DBB4D%2DE58D7AEEB238%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Age-Related Eye Disease Study II T2 - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AN - 40261647; 4374647 JF - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AU - Chew, E Y Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Eye diseases UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40261647?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.atitle=Age-Related+Eye+Disease+Study+II&rft.au=Chew%2C+E+Y&rft.aulast=Chew&rft.aufirst=E&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BC02D51F4%2D1802%2D420E% 2DBB4D%2DE58D7AEEB238%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Characterization of Late Outgrowth Circulating Endothelial Progenitor Cells from Patients with Neovascular Age-Related Macular Degeneration (AMD) T2 - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AN - 40260952; 4374671 JF - 2006 Summer Eye Research Conference of the Association for Research in Vision and Ophthalmology (SERC 2006) AU - Csaky, K G AU - Thill, M AU - Strunnikova, N AU - Ponce, L AU - Berna, M Y1 - 2006/07/09/ PY - 2006 DA - 2006 Jul 09 KW - Macular degeneration KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40260952?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.atitle=Characterization+of+Late+Outgrowth+Circulating+Endothelial+Progenitor+Cells+from+Patients+with+Neovascular+Age-Related+Macular+Degeneration+%28AMD%29&rft.au=Csaky%2C+K+G%3BThill%2C+M%3BStrunnikova%2C+N%3BPonce%2C+L%3BBerna%2C+M&rft.aulast=Csaky&rft.aufirst=K&rft.date=2006-07-09&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=2006+Summer+Eye+Research+Conference+of+the+Association+for+Research+in+Vision+and+Ophthalmology+%28SERC+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.abstractsonline.com/viewer/?mkey=%7BC02D51F4%2D1802%2D420E% 2DBB4D%2DE58D7AEEB238%7D LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - What Processes in the Brain Make a Stimulus Visible? T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39244762; 4286584 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Leopold, D A AU - Wilke, M AU - Maier, A Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - Brain KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39244762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.atitle=What+Processes+in+the+Brain+Make+a+Stimulus+Visible%3F&rft.au=Leopold%2C+D+A%3BWilke%2C+M%3BMaier%2C+A&rft.aulast=Leopold&rft.aufirst=D&rft.date=2006-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - PICK1 Regulates the GLUR2 Content of Ampars during Long-Term Synaptic Plasticity. T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39237403; 4286684 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Isaac, J T Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - alpha -Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors KW - Plasticity (synaptic) KW - Plasticity KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39237403?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.atitle=PICK1+Regulates+the+GLUR2+Content+of+Ampars+during+Long-Term+Synaptic+Plasticity.&rft.au=Isaac%2C+J+T&rft.aulast=Isaac&rft.aufirst=J&rft.date=2006-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Dopamine Cell Lesion-Induced Changes in Neuronal Activity in Motor and Anterior Cingulate Cortices in Urethane Anesthetized Rats. T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39236775; 4284113 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Parr-Brownlie, L C AU - Poloskey, S L AU - Bergstrom, D A AU - Gonzales, K K AU - Walters, J R Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - Carbamate compounds KW - Rats KW - Urethane KW - Dopamine KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39236775?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.atitle=Dopamine+Cell+Lesion-Induced+Changes+in+Neuronal+Activity+in+Motor+and+Anterior+Cingulate+Cortices+in+Urethane+Anesthetized+Rats.&rft.au=Parr-Brownlie%2C+L+C%3BPoloskey%2C+S+L%3BBergstrom%2C+D+A%3BGonzales%2C+K+K%3BWalters%2C+J+R&rft.aulast=Parr-Brownlie&rft.aufirst=L&rft.date=2006-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Exploiting Circuit-Specific Spread of Pseudorabies Virus in the Developing Spinal Cord to Investigate the Organization of the Locomotor Central Pattern Generator T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39203635; 4286828 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Jovanovic, K AU - O'donovan, M J Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - Spinal cord KW - Organizations KW - Pseudorabies virus KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39203635?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.atitle=Exploiting+Circuit-Specific+Spread+of+Pseudorabies+Virus+in+the+Developing+Spinal+Cord+to+Investigate+the+Organization+of+the+Locomotor+Central+Pattern+Generator&rft.au=Jovanovic%2C+K%3BO%27donovan%2C+M+J&rft.aulast=Jovanovic&rft.aufirst=K&rft.date=2006-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Deriving the Time Course of Glutamate Clearance from Synaptic Transporter Currents in Ca1 Astrocytes. T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39202461; 4286626 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Diamond, J S Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - Glutamic acid KW - Astrocytes KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39202461?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Accounting%2C+Auditing+%26+Accountability+Journal&rft.atitle=Corporate+response+to+climate+change%3A+language%2C+power+and+symbolic+construction&rft.au=Ferguson%2C+John%3BSales+de+Aguiar%2C+Thereza+Raquel%3BFearfull%2C+Anne&rft.aulast=Ferguson&rft.aufirst=John&rft.date=2016-02-15&rft.volume=29&rft.issue=2&rft.spage=278&rft.isbn=&rft.btitle=&rft.title=Accounting%2C+Auditing+%26+Accountability+Journal&rft.issn=13680668&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Neonatal Mammalian Spinal Motoneurons May be Directly Involved in the Generation of Locomotor-Like Activity. T2 - 5th Forum of European Neuroscience (FENS 2006) AN - 39171487; 4286447 JF - 5th Forum of European Neuroscience (FENS 2006) AU - Mentis, G Z AU - O'donovan, M J Y1 - 2006/07/08/ PY - 2006 DA - 2006 Jul 08 KW - Neonates KW - Motor neurons KW - U 2000:Biological Sciences UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/39171487?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.atitle=Neonatal+Mammalian+Spinal+Motoneurons+May+be+Directly+Involved+in+the+Generation+of+Locomotor-Like+Activity.&rft.au=Mentis%2C+G+Z%3BO%27donovan%2C+M+J&rft.aulast=Mentis&rft.aufirst=G&rft.date=2006-07-08&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=5th+Forum+of+European+Neuroscience+%28FENS+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://fens2006.neurosciences.asso.fr/prog.html LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-09-05 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Energy cost of infection burden: An approach to understanding the dynamics of host-pathogen interactions AN - 17216995; 6908937 AB - A mathematical model of long-term immune defense against infection was used to estimate the energy involved in the principal processes of immune resistance during periods of health and infection. From these values, an optimal level of energy was determined for immune response depending on infection burden. The present findings suggest that weak but prevalent pathogens lead to latent or chronic infection, whereas more virulent but less prevalent pathogens result in acute infection. This energy-based approach offers insight into the mechanisms of immune system adaptation leading to the development of chronic infectious diseases and immune deficiencies. JF - Journal of Theoretical Biology AU - Romanyukha, A A AU - Rudnev, S G AU - Sidorov, IA AD - CCR, NCI-Frederick, NIH, Bldg. 469/110, P.O. Box B, Frederick, MD 21702-1201, USA, eburg@inm.ras.ru Y1 - 2006/07/07/ PY - 2006 DA - 2006 Jul 07 SP - 1 EP - 13 VL - 241 IS - 1 SN - 0022-5193, 0022-5193 KW - Ecology Abstracts KW - Mathematical models KW - Adaptations KW - Infectious diseases KW - Energy KW - Immune system KW - Host-pathogen interactions KW - Chronic infection KW - Pathogens KW - Immune response KW - D 04003:Modeling, mathematics, computer applications UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17216995?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aecology&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Theoretical+Biology&rft.atitle=Energy+cost+of+infection+burden%3A+An+approach+to+understanding+the+dynamics+of+host-pathogen+interactions&rft.au=Romanyukha%2C+A+A%3BRudnev%2C+S+G%3BSidorov%2C+IA&rft.aulast=Romanyukha&rft.aufirst=A&rft.date=2006-07-07&rft.volume=241&rft.issue=1&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Journal+of+Theoretical+Biology&rft.issn=00225193&rft_id=info:doi/10.1016%2Fj.jtbi.2005.11.004 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-09-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Adaptations; Mathematical models; Infectious diseases; Host-pathogen interactions; Immune system; Energy; Chronic infection; Immune response; Pathogens DO - http://dx.doi.org/10.1016/j.jtbi.2005.11.004 ER - TY - JOUR T1 - Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. AN - 68718823; 16824219 AB - Pathological brain iron deposition has been implicated as a source of neurotoxic reactive oxygen species in Alzheimer (AD) and Parkinson diseases (PD). Iron metabolism is associated with the gene hemochromatosis (HFE Human genome nomenclature committee ID:4886), and mutations in HFE are a cause of the iron mismetabolism disease, hemochromatosis. Several reports have tested the association of HFE variants with neurodegenerative diseases, such as AD and PD with conflicting results. Genotypes were analysed for the two most common variants of HFE in a series of 130 AD, 55 Mild Cognitive Impairment (MCI) and 132 PD patients. Additionally, a series of 115 healthy age-matched controls was also screened. A statistically significant association was found in the PD group when compared to controls, showing that the presence of the C282Y variant allele may confer higher risk for developing the disease. Taken together these results suggest that the common variants in HFE may be a risk factor for PD, but not for AD in the Portuguese population. JF - BMC neurology AU - Guerreiro, Rita J AU - Bras, Jose M AU - Santana, Isabel AU - Januario, Cristina AU - Santiago, Beatriz AU - Morgadinho, Ana S AU - Ribeiro, Maria H AU - Hardy, John AU - Singleton, Andrew AU - Oliveira, Catarina AD - Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, USA. ritajoao@gmail.com Y1 - 2006/07/06/ PY - 2006 DA - 2006 Jul 06 SP - 24 VL - 6 KW - HFE protein, human KW - 0 KW - Hemochromatosis Protein KW - Histocompatibility Antigens Class I KW - Membrane Proteins KW - Iron KW - E1UOL152H7 KW - Index Medicus KW - Age of Onset KW - Humans KW - DNA Mutational Analysis KW - Aged KW - Brain -- metabolism KW - Iron -- metabolism KW - Comorbidity KW - Portugal -- epidemiology KW - Genotype KW - Brain -- physiopathology KW - Genetic Testing KW - Aged, 80 and over KW - Cohort Studies KW - Mutation -- genetics KW - Middle Aged KW - Genetic Variation -- genetics KW - Sample Size KW - Sex Distribution KW - Gene Frequency -- genetics KW - Male KW - Female KW - Iron Metabolism Disorders -- physiopathology KW - Alzheimer Disease -- genetics KW - Cognition Disorders -- epidemiology KW - Alzheimer Disease -- physiopathology KW - Histocompatibility Antigens Class I -- genetics KW - Parkinson Disease -- physiopathology KW - Membrane Proteins -- genetics KW - Parkinson Disease -- genetics KW - Alzheimer Disease -- epidemiology KW - Genetic Predisposition to Disease -- genetics KW - Iron Metabolism Disorders -- genetics KW - Cognition Disorders -- genetics KW - Cognition Disorders -- physiopathology KW - Iron Metabolism Disorders -- epidemiology KW - Parkinson Disease -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68718823?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=BMC+neurology&rft.atitle=Association+of+HFE+common+mutations+with+Parkinson%27s+disease%2C+Alzheimer%27s+disease+and+mild+cognitive+impairment+in+a+Portuguese+cohort.&rft.au=Guerreiro%2C+Rita+J%3BBras%2C+Jose+M%3BSantana%2C+Isabel%3BJanuario%2C+Cristina%3BSantiago%2C+Beatriz%3BMorgadinho%2C+Ana+S%3BRibeiro%2C+Maria+H%3BHardy%2C+John%3BSingleton%2C+Andrew%3BOliveira%2C+Catarina&rft.aulast=Guerreiro&rft.aufirst=Rita&rft.date=2006-07-06&rft.volume=6&rft.issue=&rft.spage=24&rft.isbn=&rft.btitle=&rft.title=BMC+neurology&rft.issn=1471-2377&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-20 N1 - Date created - 2006-08-09 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Am J Med Genet B Neuropsychiatr Genet. 2003 May 15;119B(1):48-53 [12707938] Ann Neurol. 2003;53 Suppl 3:S26-36; discussion S36-8 [12666096] Neurosci Lett. 2003 Sep 11;348(2):117-9 [12902032] Neurobiol Aging. 2004 Apr;25(4):465-74 [15013567] J Med Genet. 2004 Apr;41(4):261-5 [15060098] Ageing Res Rev. 2004 Jul;3(3):327-43 [15231240] J Psychiatr Res. 1975 Nov;12(3):189-98 [1202204] Neurology. 1984 Jul;34(7):939-44 [6610841] J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4 [1564476] Neurology. 1993 Aug;43(8):1467-72 [8350998] Neurology. 1993 Nov;43(11):2412-4 [8232972] Arch Neurol. 1999 Mar;56(3):303-8 [10190820] J Neural Transm (Vienna). 2005 Jul;112(7):921-32 [15583960] Mol Neurobiol. 2005;31(1-3):205-17 [15953822] Curr Pharm Des. 2005;11(16):2033-52 [15974957] Eur J Hum Genet. 2005 Nov;13(11):1172-85 [16132052] Semin Liver Dis. 2005 Nov;25(4):381-91 [16315132] Am J Med Genet. 2000 Jul 3;93(1):58-66 [10861683] Neurobiol Aging. 2001 Jul-Aug;22(4):563-8 [11445256] Neurosci Lett. 2002 Jul 19;327(2):91-4 [12098643] J Neurol. 2002 Jul;249(7):801-4 [12140659] Lancet. 2002 Nov 23;360(9346):1673-81 [12457803] Dement Geriatr Cogn Disord. 2003;15(3):151-4 [12584430] Mech Ageing Dev. 2003 Apr;124(4):525-8 [12714262] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Association of breast cancer outcome with status of p53 and MDM2 SNP309. AN - 68605150; 16818855 AB - A common single-nucleotide polymorphism (SNP) in the promoter region of the MDM2 gene, known as T-309G and referred to as SNP309 for this study, leads to increased expression of Mdm2 protein and attenuated function of the p53 tumor suppressor protein. We investigated whether genetic variants in MDM2 were associated with breast cancer incidence and survival and whether the variant status could interact with the tumor p53 status to modify breast cancer survival. We used multivariable logistic and Cox regression analyses to study the relationship of SNP309 status and the status of a second MDM2 SNP in exon 12 at codon 354 (SNP354) with breast cancer incidence and with disease-specific survival among 293 case patients and 317 cancer-free control subjects. Survival analysis included 248 of the 293 case patients who had known tumor p53 status. All statistical tests were two-sided. We did not observe an association between SNP309 status and breast cancer incidence in the unstratified analysis, but we did find a statistically significant association between SNP354 status and breast cancer incidence (odds ratio = 3.34, 95% confidence interval [CI] = 1.88 to 5.93). We also discovered a statistically significant interaction between SNP309 status and tumor p53 expression for breast cancer survival (P(interaction) = .002). Among homozygous carriers of the common MDM2 SNP309 allele (T/T), a mutant p53 status (risk ratio [RR] of death = 2.33, 95% CI = 1.08 to 5.03) and aberrant p53 protein expression (RR = 2.61, 95% CI = 1.22 to 5.57) in breast tumors were associated with poor survival. Tumor p53 status was not associated with breast cancer survival among carriers of the variant MDM2 SNP309 allele (G/T or G/G), which is consistent with a dominant effect of the variant allele. A strong interaction between SNP309 status and tumor p53 status appears to modify the association between p53 status and breast cancer survival. JF - Journal of the National Cancer Institute AU - Boersma, Brenda J AU - Howe, Tiffany M AU - Goodman, Julie E AU - Yfantis, Harry G AU - Lee, Dong H AU - Chanock, Stephen J AU - Ambs, Stefan AD - Laboratory of Human Carcinogenesis, National Cancer Institute, Bldg. 37/Rm. 3050B, Bethesda, MD 20892-4258, USA. Y1 - 2006/07/05/ PY - 2006 DA - 2006 Jul 05 SP - 911 EP - 919 VL - 98 IS - 13 KW - Biomarkers, Tumor KW - 0 KW - Tumor Suppressor Protein p53 KW - Guanine KW - 5Z93L87A1R KW - MDM2 protein, human KW - EC 2.3.2.27 KW - Proto-Oncogene Proteins c-mdm2 KW - Adenine KW - JAC85A2161 KW - Index Medicus KW - Odds Ratio KW - Homozygote KW - Humans KW - Aged KW - Predictive Value of Tests KW - Risk Assessment KW - Promoter Regions, Genetic KW - Haplotypes KW - Risk Factors KW - Adult KW - Case-Control Studies KW - Incidence KW - Middle Aged KW - Female KW - Survival Analysis KW - Breast Neoplasms -- genetics KW - Biomarkers, Tumor -- genetics KW - Polymorphism, Single Nucleotide KW - Breast Neoplasms -- mortality KW - Proto-Oncogene Proteins c-mdm2 -- genetics KW - Tumor Suppressor Protein p53 -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68605150?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Association+of+breast+cancer+outcome+with+status+of+p53+and+MDM2+SNP309.&rft.au=Boersma%2C+Brenda+J%3BHowe%2C+Tiffany+M%3BGoodman%2C+Julie+E%3BYfantis%2C+Harry+G%3BLee%2C+Dong+H%3BChanock%2C+Stephen+J%3BAmbs%2C+Stefan&rft.aulast=Boersma&rft.aufirst=Brenda&rft.date=2006-07-05&rft.volume=98&rft.issue=13&rft.spage=911&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=1460-2105&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-13 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Rapidly Increasing Incidence of Ocular Non-Hodgkin Lymphoma AN - 19960436; 6997371 AB - A recent report suggesting that ocular adnexal non-Hodgkin lymphoma (NHL) may be related to Chlamydia psittaci infection underscores the need for reliable epidemiologic data for this malignancy. We examined population-based incidence data from the Surveillance, Epidemiology, and End Results (SEER) Program. During 1992-2001 in the 12 SEER areas, ocular (i.e., eye and adnexa) NHL rates per 100 000 person-years for both sexes were highest among Asians/Pacific Islanders, lower in whites, and lower still in blacks. Incidence increased with advancing age and showed little difference by sex, in contrast to other (extranodal and nodal) NHLs, which occurred predominantly in males. From 1975-2001, there was a rapid and steady increase in incidence of ocular NHL, with annual increases of 6.2% and 6.5% among white males and females, respectively, with no evidence of peaking. By contrast, other NHLs showed evidence of peaking in recent years. The distinctive patterns of ocular NHL call for further studies to identify risk factors and mechanisms, including the potential role of C. psittaci or other infections. JF - Journal of the National Cancer Institute AU - Moslehi, Roxana AU - Devesa, Susan S AU - Schairer, Catherine AU - Fraumeni, Joseph FJr AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD Y1 - 2006/07/05/ PY - 2006 DA - 2006 Jul 05 SP - 936 EP - 939 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 13 SN - 0027-8874, 0027-8874 KW - Non-Hodgkin's lymphoma KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Risk Abstracts KW - Age KW - Data processing KW - Eye KW - Chlamydia psittaci KW - Infection KW - Cancer KW - Malignancy KW - Epidemiology KW - Risk factors KW - infection KW - lymphoma KW - Lymphoma KW - Sex KW - F 06915:Cancer Immunology KW - R2 23060:Medical and environmental health KW - J 02490:Miscellaneous UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19960436?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Rapidly+Increasing+Incidence+of+Ocular+Non-Hodgkin+Lymphoma&rft.au=Moslehi%2C+Roxana%3BDevesa%2C+Susan+S%3BSchairer%2C+Catherine%3BFraumeni%2C+Joseph+FJr&rft.aulast=Moslehi&rft.aufirst=Roxana&rft.date=2006-07-05&rft.volume=98&rft.issue=13&rft.spage=936&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Age; Malignancy; Data processing; Epidemiology; Eye; Risk factors; Infection; Lymphoma; Sex; infection; lymphoma; Cancer; Chlamydia psittaci ER - TY - JOUR T1 - Established breast cancer risk factors by clinically important tumour characteristics AN - 954574388; 13759432 AB - Breast cancer is a morphologically and clinically heterogeneous disease; however, it is less clear how risk factors relate to tumour features. We evaluated risk factors by tumour characteristics (histopathologic type, grade, size, and nodal status) in a population-based case-control of 2386 breast cancers and 2502 controls in Poland. Use of a novel extension of the polytomous logistic regression permitted simultaneous modelling of multiple tumour characteristics. Late age at first full-term birth was associated with increased risk of large (>2cm) tumours (odds ratios (95% confidence intervals) 1.19 (1.07-1.33) for a 5-year increase in age), but not smaller tumours (P for heterogeneity adjusting for other tumour features (P sub(het))=0.007). On the other hand, multiparity was associated with reduced risk for small tumours (0.76 (0.68-0.86) per additional birth; P sub(het)=0.004). Consideration of all tumour characteristics simultaneously revealed that current or recent use of combined hormone replacement therapy was associated with risk of small (2.29 (1.66-3.15)) and grade 1 (3.36 (2.22-5.08)) tumours (P sub(het)=0.05 for size and 0.0008 for grade 1 vs 3), rather than specific histopathologic types (P sub(het)=0.63 for ductal vs lobular). Finally, elevated body mass index was associated with larger tumour size among both pre- and postmenopausal women (P sub(het)=0.05 and 0.0001, respectively). None of these relationships were explained by hormone receptor status of the tumours. In conclusion, these data support distinctive risk factor relationships by tumour characteristics of prognostic relevance. These findings might be useful in developing targeted prevention efforts.British Journal of Cancer (2006) 95, 123-129. doi:10.1038/sj.bjc.6603207 www.bjcancer.com Published online 6 June 2006 JF - British Journal of Cancer AU - Garcia-Closas, M AU - Brinton, L A AU - Lissowska, J AU - Chatterjee, N AU - Peplonska, B AU - Anderson, W F AU - Szeszenia-Dabrowska, N AU - Bardin-Mikolajczak, A AU - Zatonski, W AU - Blair, A AU - Kalaylioglu, Z AU - Rymkiewicz, G AU - Mazepa-Sikora, D AU - Kordek, R AU - Lukaszek, S AU - Sherman, M E AD - 1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institute of Health, 6120 Executive Blvd. Room 7076, Rockville, MD 20852-7234, USA Y1 - 2006/07/03/ PY - 2006 DA - 2006 Jul 03 SP - 123 EP - 129 PB - Nature Publishing Group, The Macmillan Building London N1 9XW UK VL - 95 IS - 1 SN - 0007-0920, 0007-0920 KW - Risk Abstracts; Health & Safety Science Abstracts KW - Age KW - post-menopause KW - Hormones KW - Cancer KW - risk reduction KW - body mass KW - Poland KW - prevention KW - Breast cancer KW - hormone replacement therapy KW - H 11000:Diseases/Injuries/Trauma KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/954574388?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=British+Journal+of+Cancer&rft.atitle=Established+breast+cancer+risk+factors+by+clinically+important+tumour+characteristics&rft.au=Garcia-Closas%2C+M%3BBrinton%2C+L+A%3BLissowska%2C+J%3BChatterjee%2C+N%3BPeplonska%2C+B%3BAnderson%2C+W+F%3BSzeszenia-Dabrowska%2C+N%3BBardin-Mikolajczak%2C+A%3BZatonski%2C+W%3BBlair%2C+A%3BKalaylioglu%2C+Z%3BRymkiewicz%2C+G%3BMazepa-Sikora%2C+D%3BKordek%2C+R%3BLukaszek%2C+S%3BSherman%2C+M+E&rft.aulast=Garcia-Closas&rft.aufirst=M&rft.date=2006-07-03&rft.volume=95&rft.issue=1&rft.spage=123&rft.isbn=&rft.btitle=&rft.title=British+Journal+of+Cancer&rft.issn=00070920&rft_id=info:doi/10.1038%2Fsj.bjc.6603207 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2012-03-01 N1 - Last updated - 2012-03-30 N1 - SubjectsTermNotLitGenreText - risk reduction; Age; post-menopause; body mass; prevention; Breast cancer; Hormones; hormone replacement therapy; Cancer; Poland DO - http://dx.doi.org/10.1038/sj.bjc.6603207 ER - TY - CPAPER T1 - Chromatin in Embryonic Stem Cell Neuronal Differentiation T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40254593; 4364560 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Meshorer, Eran Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Differentiation KW - Chromatin KW - Embryo cells KW - Stem cells UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254593?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Chromatin+in+Embryonic+Stem+Cell+Neuronal+Differentiation&rft.au=Meshorer%2C+Eran&rft.aulast=Meshorer&rft.aufirst=Eran&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Use of Gene Targeting Technology to Understand the Roles of CNS Muscarinic Receptors T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40254516; 4364527 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Jurgen, Wess Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Gene targeting KW - Central nervous system KW - Acetylcholine receptors (muscarinic) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40254516?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Use+of+Gene+Targeting+Technology+to+Understand+the+Roles+of+CNS+Muscarinic+Receptors&rft.au=Jurgen%2C+Wess&rft.aulast=Jurgen&rft.aufirst=Wess&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Endocannabinoids and the Control of Regulation of Energy Homeostasis T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40251069; 4364458 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - George, Kunos Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Energy balance KW - Cannabinoids UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40251069?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Endocannabinoids+and+the+Control+of+Regulation+of+Energy+Homeostasis&rft.au=George%2C+Kunos&rft.aulast=George&rft.aufirst=Kunos&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - STAT1 Contributes to TLR3 Ligand Inhibition of Liver Regeneration and Inversely Correlates with Hepatocyte Proliferation in HCV Patients T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40250065; 4365908 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Rui, Sun AU - Shailin, Kulkarni AU - Lei, Wang AU - Hao-Yu AU - Svetlana, Radaeva AU - Bin, Gao Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Liver KW - Hepatocytes KW - Stat1 protein KW - Ligands KW - Hepatitis C virus UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40250065?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=STAT1+Contributes+to+TLR3+Ligand+Inhibition+of+Liver+Regeneration+and+Inversely+Correlates+with+Hepatocyte+Proliferation+in+HCV+Patients&rft.au=Rui%2C+Sun%3BShailin%2C+Kulkarni%3BLei%2C+Wang%3BHao-Yu%3BSvetlana%2C+Radaeva%3BBin%2C+Gao&rft.aulast=Rui&rft.aufirst=Sun&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Genetic Perspectives on SRI Actions T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40249136; 4364584 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Murphy, Dennis L Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Pharmacology KW - Serotonin uptake inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40249136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Genetic+Perspectives+on+SRI+Actions&rft.au=Murphy%2C+Dennis+L&rft.aulast=Murphy&rft.aufirst=Dennis&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacogenetics of Prostate Cancer T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40249076; 4364568 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Figg, William D Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Prostate cancer KW - Pharmacogenetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40249076?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Pharmacogenetics+of+Prostate+Cancer&rft.au=Figg%2C+William+D&rft.aulast=Figg&rft.aufirst=William&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Interfacial Inhibition: Topoisomerase Inhibitors, One of Nature's Paradigm for Drug Discovery T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40245058; 4364330 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Yves, Pommier Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Drug discovery KW - Inhibitors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40245058?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Interfacial+Inhibition%3A+Topoisomerase+Inhibitors%2C+One+of+Nature%27s+Paradigm+for+Drug+Discovery&rft.au=Yves%2C+Pommier&rft.aulast=Yves&rft.aufirst=Pommier&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Blockade of Cannabinoid CB1 Receptor by AM251 Inhibits Cocaine's Rewarding Effects and Cocaine-Primed Relapse by a DA-Independent Mechanism T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40240006; 4365011 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Xi, Zheng-Xiong AU - Gardner, Eliot Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Reinforcement KW - Cannabinoid CB1 receptors UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40240006?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Blockade+of+Cannabinoid+CB1+Receptor+by+AM251+Inhibits+Cocaine%27s+Rewarding+Effects+and+Cocaine-Primed+Relapse+by+a+DA-Independent+Mechanism&rft.au=Xi%2C+Zheng-Xiong%3BGardner%2C+Eliot&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Gamma-vinyl GABA Inhibits Cocaine-Primed Relapse by a DA-Independent Mechanism T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40239289; 4364883 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Gardner, Eliot AU - Xi, Zheng-Xiong Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - ^g-Aminobutyric acid UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40239289?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Gamma-vinyl+GABA+Inhibits+Cocaine-Primed+Relapse+by+a+DA-Independent+Mechanism&rft.au=Gardner%2C+Eliot%3BXi%2C+Zheng-Xiong&rft.aulast=Gardner&rft.aufirst=Eliot&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Mouse Metabonomics for the Analysis and Prediction of Drug Metabolism T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40237661; 4364454 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Gonzalez, Frank J Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Metabolism KW - Drugs KW - Drug metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40237661?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Mouse+Metabonomics+for+the+Analysis+and+Prediction+of+Drug+Metabolism&rft.au=Gonzalez%2C+Frank+J&rft.aulast=Gonzalez&rft.aufirst=Frank&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - CPAPER T1 - Pharmacological Modulation of Oxidative-Nitrosative Stress and Downstream Effectors in Heart Failure T2 - 15th World Congress of Pharmacology (IUPHAR 2006) AN - 40237623; 4364453 JF - 15th World Congress of Pharmacology (IUPHAR 2006) AU - Pal, Pacher Y1 - 2006/07/02/ PY - 2006 DA - 2006 Jul 02 KW - Stress KW - Heart UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/40237623?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acpi&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=conference&rft.jtitle=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.atitle=Pharmacological+Modulation+of+Oxidative-Nitrosative+Stress+and+Downstream+Effectors+in+Heart+Failure&rft.au=Pal%2C+Pacher&rft.aulast=Pal&rft.aufirst=Pacher&rft.date=2006-07-02&rft.volume=&rft.issue=&rft.spage=&rft.isbn=&rft.btitle=&rft.title=15th+World+Congress+of+Pharmacology+%28IUPHAR+2006%29&rft.issn=&rft_id=info:doi/ L2 - http://www.iuphar2006.org/iuphar/.do?techProgram LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2008-05-27 N1 - Last updated - 2010-05-03 ER - TY - JOUR T1 - Survival of Parkinson's disease patients in a large prospective cohort of male health professionals. AN - 85391459; pmid-16602107 AB - Parkinson's disease (PD) patients have higher mortality than individuals without PD. However, most of the previous studies were based on prevalent cases and few examined the potential effects of duration and smoking on the survival of PD patients. We compared the survival experience of 288 men with incident PD diagnosed between 1986 and 2000 with that of 51,012 men free of PD in the Health Professionals Follow-up Study. As of January 2002, 92 deaths occurred among PD cases and 8,485 among men without PD. After controlling for age, men with PD had 60% higher mortality than those without PD (95% CI: 1.3-2.0). PD mortality was strongly related to disease duration: compared with men without PD, the age-adjusted relative risk for PD patients was 1.1 during the first 5 years from diagnosis, 2.3 from 5 to 10 years, and 3.5 after 10 years (P 30 pack-years vs. never smokers, relative risk, 2.0; P < 0.0001 for trend), but this association was not observed among PD patients (RR: 1.0; P = 0.95 for trend). This study confirms that PD patients have a higher mortality than individuals without PD and that the excess mortality increases with disease duration. However, smoking seems to impose little additional risk among PD patients in this large cohort of health professionals.(c) 2006 Movement Disorder Society. JF - Movement disorders : official journal of the Movement Disorder Society AU - Chen, Honglei AU - Zhang, Shumin M AU - Schwarzschild, Michael A AU - Hernán, Miguel A AU - Ascherio, Alberto AD - Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Chenh2@niehs.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1002 EP - 1007 VL - 21 IS - 7 SN - 0885-3185, 0885-3185 KW - Index Medicus KW - National Library of Medicine KW - Age Factors KW - Aged KW - Aged, 80 and over KW - Cohort Studies KW - Follow-Up Studies KW - *Health Personnel: statistics & numerical data KW - Humans KW - Male KW - Massachusetts KW - Middle Aged KW - Parkinson Disease: diagnosis KW - *Parkinson Disease: mortality KW - Prospective Studies KW - Reference Values KW - Risk KW - Smoking: adverse effects KW - Smoking: mortality KW - Statistics as Topic KW - Survival Analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/85391459?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Acomdisdome&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.atitle=Survival+of+Parkinson%27s+disease+patients+in+a+large+prospective+cohort+of+male+health+professionals.&rft.au=Chen%2C+Honglei%3BZhang%2C+Shumin+M%3BSchwarzschild%2C+Michael+A%3BHern%C3%A1n%2C+Miguel+A%3BAscherio%2C+Alberto&rft.aulast=Chen&rft.aufirst=Honglei&rft.date=2006-07-01&rft.volume=21&rft.issue=7&rft.spage=1002&rft.isbn=&rft.btitle=&rft.title=Movement+disorders+%3A+official+journal+of+the+Movement+Disorder+Society&rft.issn=08853185&rft_id=info:doi/ LA - English (eng) DB - ComDisDome N1 - Date revised - 2011-12-15 N1 - Last updated - 2012-07-13 ER - TY - JOUR T1 - New drugs from marine microbes: the tide is turning AN - 754567986; 13416651 AB - This is a mini-review demonstrating that investigation of the genomics of marine microbes from all three domains has the potential to revolutionize the search for secondary metabolites originally thought to be the product of marine invertebrates. The basis for the review was a symposium at the 2005 Annual Meeting of the SIM covering some aspects of the potential for marine microbes to be the primary producers of such metabolites. The work reported at that symposium has been integrated into a fuller discussion of current published literature on the subject with examples drawn from bacteria, cyanophytes and fungi. JF - Journal of Industrial Microbiology & Biotechnology AU - Newman, David J AU - Hill, Russell T AD - Natural Products Branch, Developmental Therapeutics Program, NCI-Frederick, P. O. Box B, Frederick, MD, 21702, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 539 EP - 544 PB - Springer-Verlag, Tiergartenstrasse 17 Heidelberg 69121 Germany VL - 33 IS - 7 SN - 1367-5435, 1367-5435 KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Microbiology Abstracts C: Algology, Mycology & Protozoology; ASFA 1: Biological Sciences & Living Resources; Biotechnology and Bioengineering Abstracts KW - Marine KW - Marine invertebrates KW - Fungi KW - Metabolites KW - Tides KW - Reviews KW - Aquatic drugs KW - Microbiology KW - Secondary metabolites KW - genomics KW - Drugs KW - Biotechnology KW - Q1 08206:Physiology, biochemistry, biophysics KW - A 01490:Miscellaneous KW - K 03450:Ecology KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/754567986?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.atitle=New+drugs+from+marine+microbes%3A+the+tide+is+turning&rft.au=Newman%2C+David+J%3BHill%2C+Russell+T&rft.aulast=Newman&rft.aufirst=David&rft.date=2006-07-01&rft.volume=33&rft.issue=7&rft.spage=539&rft.isbn=&rft.btitle=&rft.title=Journal+of+Industrial+Microbiology+%26+Biotechnology&rft.issn=13675435&rft_id=info:doi/10.1007%2Fs10295-006-0115-2 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-08-01 N1 - Last updated - 2014-05-02 N1 - SubjectsTermNotLitGenreText - Marine invertebrates; Aquatic drugs; Fungi; Microbiology; Biotechnology; Reviews; Secondary metabolites; Metabolites; genomics; Drugs; Tides; Marine DO - http://dx.doi.org/10.1007/s10295-006-0115-2 ER - TY - JOUR T1 - Protecting third parties in human subjects research. AN - 68957681; 17036432 JF - IRB AU - Resnik, David B AU - Sharp, Richard R AD - National Institute of Environmental Health Sciences Institutional Review Board, National Institutes of Health, Research Triange Park, NC, USA. PY - 2006 SP - 1 EP - 7 VL - 28 IS - 4 SN - 0193-7758, 0193-7758 KW - Hazardous Substances KW - 0 KW - Pesticides KW - Bioethics KW - Biomedical and Behavioral Research KW - United States KW - Pedigree KW - Research Personnel -- ethics KW - Government Regulation KW - Beneficence KW - Humans KW - Pesticides -- toxicity KW - Research Personnel -- legislation & jurisprudence KW - Privacy KW - Data Collection KW - Researcher-Subject Relations KW - Third-Party Consent -- ethics KW - Ethics Committees, Research -- legislation & jurisprudence KW - Safety Management -- legislation & jurisprudence KW - Federal Government KW - Liability, Legal KW - Pregnancy KW - Disclosure -- ethics KW - Safety Management -- ethics KW - Pregnant Women KW - Health Surveys KW - Family KW - Ethics Committees, Research -- ethics KW - Female KW - Risk Assessment -- ethics KW - Research Subjects -- classification KW - Human Experimentation -- ethics KW - Human Experimentation -- legislation & jurisprudence KW - Social Responsibility KW - Risk Assessment -- legislation & jurisprudence UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68957681?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=IRB&rft.atitle=Protecting+third+parties+in+human+subjects+research.&rft.au=Resnik%2C+David+B%3BSharp%2C+Richard+R&rft.aulast=Resnik&rft.aufirst=David&rft.date=2006-07-01&rft.volume=28&rft.issue=4&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=IRB&rft.issn=01937758&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-31 N1 - Date created - 2006-10-11 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunol Allergy Clin North Am. 2003 Aug;23(3):483-99 [14524387] IRB. 2005 Jul-Aug;27(4):1-6 [16220627] JAMA. 2001 Jan 10;285(2):207-11 [11176815] J Contin Educ Health Prof. 2001 Fall;21(4):271-7 [11803772] Ann Intern Med. 2003 Jul 1;139(1):40-5 [12834317] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Studies of the effects of neonatal exposure to genistein on the developing female reproductive system. AN - 68758541; 16918037 AB - Studies have shown that developmental exposure to genistein alters murine reproductive differentiation, resulting in abnormal ovarian development (multioocyte follicles) and uterine neoplasia later in life. Further, reproductive function was altered. Prolonged estrous cyclicity was observed following neonatal genistein treatment (0.5-50 mg/kg) on Days 1-5 with dose- and age-related increase in severity. Fertility, determined at 2, 4, and 6 months, showed decreased numbers of genistein-treated females (0.5 or 5 mg/kg) delivering live pups and reduced numbers of pups. At 6 months, 60% of 0.5 mg/kg and 40% of 5 mg/kg groups delivered live pups compared to 100% of controls. At 2 months, half the mice treated with 25 mg/kg of genistein and none treated with 50 mg/kg delivered live pups, although half of the latter group showed signs of pregnancy with few small implantation sites. Ovarian function was disrupted in the low genistein-dosed mice with increased numbers of corpora lutea (CLs) compared to controls and increased ovulated oocytes following exogenous gonadotropins treatment. In contrast, mice treated with high genistein doses had decreased numbers of CLs; ovulation could be restored with exogenous gonadotropins. Thus, neonatal treatment with genistein at environmentally relevant doses caused adverse consequences on ovarian development and reproductive function. JF - Journal of AOAC International AU - Jefferson, Wendy N AU - Padilla-Banks, Elizabeth AU - Newbold, Retha R AD - National Institute of Environmental Health Sciences, NIH, DHHS, Developmental Endocrinology and Endocrine Disruptor Section, Laboratory of Molecular Toxicology, Research Triangle Park, NC 27709, USA. jeffers1@niehs.nih.gov PY - 2006 SP - 1189 EP - 1196 VL - 89 IS - 4 SN - 1060-3271, 1060-3271 KW - Gonadotropins KW - 0 KW - Phytoestrogens KW - Genistein KW - DH2M523P0H KW - Index Medicus KW - Animals KW - Dose-Response Relationship, Drug KW - Ovary -- drug effects KW - Gonadotropins -- metabolism KW - Mice KW - Corpus Luteum -- drug effects KW - Phytoestrogens -- metabolism KW - Time Factors KW - Estrous Cycle -- drug effects KW - Female KW - Animals, Newborn KW - Reproduction -- drug effects KW - Genistein -- pharmacology KW - Genistein -- adverse effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68758541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+AOAC+International&rft.atitle=Studies+of+the+effects+of+neonatal+exposure+to+genistein+on+the+developing+female+reproductive+system.&rft.au=Jefferson%2C+Wendy+N%3BPadilla-Banks%2C+Elizabeth%3BNewbold%2C+Retha+R&rft.aulast=Jefferson&rft.aufirst=Wendy&rft.date=2006-07-01&rft.volume=89&rft.issue=4&rft.spage=1189&rft.isbn=&rft.btitle=&rft.title=Journal+of+AOAC+International&rft.issn=10603271&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-08-18 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Methods for reverse genetic screening in zebrafish by resequencing and TILLING. AN - 68743407; 16828311 AB - Animal models provide an in vivo system to study gene function by transgenic and knockout approaches. Targeted knockout approaches have been very successful in mice, but are currently not feasible in zebrafish due to the inability to grow embryonic stem cells. As an alternative, a reverse genetic approach that utilizes screening by resequencing and/or TILLING (Targeting Induced Local Lesions INGenomes) of mutagenized genomes has recently gained popularity in the zebrafish field. Spermatogonia of healthy males are mutagenized using ENU (N-ethyl-N-nitrosourea) and F1 progeny is collected by breeding treated males with healthy wild type females. Sperm and DNA banks are generated from F1 males. DNA is screened for ENU-induced mutations by sequencing or TILLING. These mutations can then be studied by in vitro fertilization (IVF) from the cryopreserved sperm of the corresponding F1 male followed by breeding to homozygosity. A high-throughput method of screening for rare heterozygotes and efficient recovery of mutant lines are important in identification of a large number of mutations using this approach. This article provides optimized protocols for resequencing and TILLING based on our experiences. We performed a pilot screen on 1235 F1 males by resequencing 54 exons from 17 genes and analyzed the sequencing data using multiple programs to maximize the mutation detection with minimal false positive detection. As an alternative to sequencing, we developed the protocols for TILLING by capillary electrophoresis using an ABI Genetic analyzer 3100 platform followed by fragment analysis using GeneScan and Genotyper softwares. PCR products generated by fluorescently labeled universal primers and tailed exon-specific primers were pooled 4-fold prior to heteroduplex formation. Overall, our pilot screen shows that a combination of TILLING and sequencing is optimal for achieving cost-effective, high-throughput screening of a large number of samples. Amplicons with fewer common SNPs are ideal for TILLING whereas amplicons with multiple SNPs and in/del polymorphisms are best suited for sequencing followed by analysis with SNPdetector. JF - Methods (San Diego, Calif.) AU - Sood, Raman AU - English, Milton A AU - Jones, MaryPat AU - Mullikin, James AU - Wang, Duen-Mei AU - Anderson, Maria AU - Wu, Dongying AU - Chandrasekharappa, Settara C AU - Yu, Jun AU - Zhang, Jinghui AU - Paul Liu, P AD - Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA. rsood@mial.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 220 EP - 227 VL - 39 IS - 3 SN - 1046-2023, 1046-2023 KW - Ethylnitrosourea KW - P8M1T4190R KW - Index Medicus KW - Semen Preservation -- methods KW - Software KW - Animals KW - Polymorphism, Single Nucleotide KW - Testis KW - Spermatogonia -- drug effects KW - Fertilization in Vitro KW - Cryopreservation -- methods KW - Computational Biology KW - Genome KW - Male KW - Female KW - Ethylnitrosourea -- pharmacology KW - Gene Targeting -- methods KW - DNA Mutational Analysis -- methods KW - Zebrafish -- growth & development KW - Zebrafish -- genetics KW - Mutagenesis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68743407?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Methods+%28San+Diego%2C+Calif.%29&rft.atitle=Methods+for+reverse+genetic+screening+in+zebrafish+by+resequencing+and+TILLING.&rft.au=Sood%2C+Raman%3BEnglish%2C+Milton+A%3BJones%2C+MaryPat%3BMullikin%2C+James%3BWang%2C+Duen-Mei%3BAnderson%2C+Maria%3BWu%2C+Dongying%3BChandrasekharappa%2C+Settara+C%3BYu%2C+Jun%3BZhang%2C+Jinghui%3BPaul+Liu%2C+P&rft.aulast=Sood&rft.aufirst=Raman&rft.date=2006-07-01&rft.volume=39&rft.issue=3&rft.spage=220&rft.isbn=&rft.btitle=&rft.title=Methods+%28San+Diego%2C+Calif.%29&rft.issn=10462023&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-12-12 N1 - Date created - 2006-08-15 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. AN - 68717669; 16891467 AB - sigma Ligands have recently been shown to have cytotoxic activity, to induce ceramide-dependent/caspase-independent apoptosis, and to down-regulate P-glycoprotein (P-gp) mRNA levels in some mouse and human models. In this study, we verified whether a mixed sigma(2) agonist/sigma(1) antagonist, PB28, was able to have antitumor activity and to enhance anthracycline efficacy in two human breast cancer cell lines, MCF7 and MCF7 ADR, both characterized by significant sigma(2) receptor expression, by high and low sigma(1) receptor expression, and low and high P-gp expression, respectively. In both cell lines, PB28 showed high sigma(2) receptor affinity and low sigma(1) receptor affinity; furthermore, it inhibited cell growth with a clear effect at 48 hours (IC(50) in nanomolar range), a consistent time exposure-independent increase of G(0)-G(1)-phase fraction (of approximately 20% of both cell lines) and caspase-independent apoptosis (15% increased after 1-day drug exposure). PB28 also reduced P-gp expression in a concentration- and time-dependent manner ( approximately 60% in MCF7 and 90% in MCF7 ADR). We showed also a strong synergism between PB28 and doxorubicin by adopting either simultaneous or sequential schedules of the two drugs. We suggest that this synergism could depend on PB28-induced increase of intracellular accumulation of doxorubicin ( approximately 50% in MCF7 and 75% in MCF7 ADR by flow cytometry analysis). In conclusion, we suggest that the sigma(2) agonist PB28 could be an interesting antitumor agent either in monotherapy or in combination with conventional drugs. JF - Molecular cancer therapeutics AU - Azzariti, Amalia AU - Colabufo, Nicola A AU - Berardi, Francesco AU - Porcelli, Letizia AU - Niso, Mauro AU - Simone, Grazia M AU - Perrone, Roberto AU - Paradiso, Angelo AD - Clinical Experimental Oncology Laboratory, National Cancer Institute, Via Amendola 209, 70125 Bari, Italy. amaliaris@yahoo.com Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1807 EP - 1816 VL - 5 IS - 7 SN - 1535-7163, 1535-7163 KW - Anthracyclines KW - 0 KW - Antineoplastic Agents KW - P-Glycoprotein KW - PB28 compound KW - Piperazines KW - Receptors, sigma KW - sigma-1 receptor KW - sigma-2 receptor KW - Daunorubicin KW - ZS7284E0ZP KW - Index Medicus KW - Cell Proliferation -- drug effects KW - Apoptosis KW - Anthracyclines -- therapeutic use KW - Anthracyclines -- pharmacology KW - P-Glycoprotein -- metabolism KW - Humans KW - Cell Line, Tumor KW - Drug Synergism KW - Antineoplastic Agents -- therapeutic use KW - Antineoplastic Agents -- pharmacology KW - Female KW - Cell Cycle -- drug effects KW - Daunorubicin -- pharmacology KW - Breast Neoplasms -- drug therapy KW - Receptors, sigma -- antagonists & inhibitors KW - Piperazines -- therapeutic use KW - Daunorubicin -- therapeutic use KW - Receptors, sigma -- agonists KW - Piperazines -- pharmacology KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68717669?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+cancer+therapeutics&rft.atitle=Cyclohexylpiperazine+derivative+PB28%2C+a+sigma2+agonist+and+sigma1+antagonist+receptor%2C+inhibits+cell+growth%2C+modulates+P-glycoprotein%2C+and+synergizes+with+anthracyclines+in+breast+cancer.&rft.au=Azzariti%2C+Amalia%3BColabufo%2C+Nicola+A%3BBerardi%2C+Francesco%3BPorcelli%2C+Letizia%3BNiso%2C+Mauro%3BSimone%2C+Grazia+M%3BPerrone%2C+Roberto%3BParadiso%2C+Angelo&rft.aulast=Azzariti&rft.aufirst=Amalia&rft.date=2006-07-01&rft.volume=5&rft.issue=7&rft.spage=1807&rft.isbn=&rft.btitle=&rft.title=Molecular+cancer+therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-10-10 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders in the United States: Results of the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68714974; 16889449 AB - To present national data on the prevalence, correlates, and comorbidity of nonmedical prescription drug use and drug use disorders for sedatives, tranquilizers, opioids, and amphetamines. Data were derived from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a face-to-face nationally representative survey of 43,093 adults conducted during 2001 and 2002. Lifetime prevalences of nonmedical use of sedatives, tranquilizers, opioids, and amphetamines were 4.1%, 3.4%, 4.7%, and 4.7%, respectively. Corresponding rates of abuse and/or dependence on these substances were 1.1%, 1.0%, 1.4%, and 2.0%. The odds of nonmedical prescription drug use and drug use disorders were generally greater among men, Native Americans, young and middle-aged, those who were widowed/ separated/divorced or never married, and those residing in the West. Abuse/dependence liability was greatest for amphetamines, and nonmedical prescription drug use disorders were highly comorbid with other Axis I and II disorders. The majority of individuals with non-medical prescription drug use disorders never received treatment. Nonmedical prescription drug use and disorders are pervasive in the U.S. population and highly comorbid with other psychiatric disorders. Native Americans had significantly greater rates of nonmedical prescription drug use and drug use disorders, highlighting the need for culturally-sensitive prevention and intervention programs. Unprecedented comorbidity between nonmedical prescription drug use disorders and between nonmedical prescription drug use disorders and illicit drug use disorders suggests that the typical individual abusing or dependent on these drugs obtained them illegally, rather than through a physician. Amphetamines had the greatest abuse/dependence liability, and recent increases in the potency of illegally manufactured amphetamines may portend an epidemic in the youngest NESARC cohort. JF - The Journal of clinical psychiatry AU - Huang, Boji AU - Dawson, Deborah A AU - Stinson, Frederick S AU - Hasin, Deborah S AU - Ruan, W June AU - Saha, Tulshi D AU - Smith, Sharon M AU - Goldstein, Risë B AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1062 EP - 1073 VL - 67 IS - 7 SN - 0160-6689, 0160-6689 KW - Hypnotics and Sedatives KW - 0 KW - Psychotropic Drugs KW - Street Drugs KW - Tranquilizing Agents KW - Index Medicus KW - Amphetamine-Related Disorders -- epidemiology KW - Opioid-Related Disorders -- epidemiology KW - Alcoholism -- epidemiology KW - Humans KW - Street Drugs -- adverse effects KW - Health Surveys KW - Adult KW - Psychotropic Drugs -- adverse effects KW - Hypnotics and Sedatives -- adverse effects KW - Tranquilizing Agents -- adverse effects KW - United States -- epidemiology KW - Comorbidity KW - Prevalence KW - Drug Prescriptions -- statistics & numerical data KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68714974?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+clinical+psychiatry&rft.atitle=Prevalence%2C+correlates%2C+and+comorbidity+of+nonmedical+prescription+drug+use+and+drug+use+disorders+in+the+United+States%3A+Results+of+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Huang%2C+Boji%3BDawson%2C+Deborah+A%3BStinson%2C+Frederick+S%3BHasin%2C+Deborah+S%3BRuan%2C+W+June%3BSaha%2C+Tulshi+D%3BSmith%2C+Sharon+M%3BGoldstein%2C+Ris%C3%AB+B%3BGrant%2C+Bridget+F&rft.aulast=Huang&rft.aufirst=Boji&rft.date=2006-07-01&rft.volume=67&rft.issue=7&rft.spage=1062&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+clinical+psychiatry&rft.issn=01606689&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-08-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Heavy metal pad shielding during fluoroscopic interventions. AN - 68679337; 16868175 AB - Significant direct and scatter radiation doses to patient and physician may result from routine interventional radiology practice. A lead-free disposable tungsten antimony shielding pad was tested in phantom patients during simulated diagnostic angiography procedures. Although the exact risk of low doses of ionizing radiation is unknown, dramatic dose reductions can be seen with routine use of this simple, sterile pad made from lightweight tungsten antimony material. JF - Journal of vascular and interventional radiology : JVIR AU - Dromi, Sergio AU - Wood, Bradford J AU - Oberoi, Jay AU - Neeman, Ziv AD - Special Procedures, Diagnostic Radiology Department, National Institutes of Health, Building 10, Room 1C662, 10 Center Drive, Bethesda, MD 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1201 EP - 1206 VL - 17 IS - 7 SN - 1051-0443, 1051-0443 KW - Index Medicus KW - Phantoms, Imaging KW - Radiation Dosage KW - Humans KW - Radiography, Interventional KW - Radiation Protection -- instrumentation KW - Fluoroscopy -- adverse effects KW - Protective Devices UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68679337?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.atitle=Heavy+metal+pad+shielding+during+fluoroscopic+interventions.&rft.au=Dromi%2C+Sergio%3BWood%2C+Bradford+J%3BOberoi%2C+Jay%3BNeeman%2C+Ziv&rft.aulast=Dromi&rft.aufirst=Sergio&rft.date=2006-07-01&rft.volume=17&rft.issue=7&rft.spage=1201&rft.isbn=&rft.btitle=&rft.title=Journal+of+vascular+and+interventional+radiology+%3A+JVIR&rft.issn=10510443&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-12 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-14 N1 - SuppNotes - Cited By: Radiographics. 2000 Jul-Aug;20(4):1033-42 [10903693] Ann ICRP. 2000;30(2):7-67 [11459599] Radiographics. 2001 Jul-Aug;21(4):1033-45 [11452079] AJR Am J Roentgenol. 2002 Jan;178(1):153-7 [11756110] Arch Phys Med Rehabil. 2002 May;83(5):697-701 [11994810] Semin Ultrasound CT MR. 2002 Oct;23(5):423-7 [12509112] J Vasc Interv Radiol. 2003 Jun;14(6):711-27 [12817038] Rontgenpraxis. 2003;55(2):51-7 [14618963] Radiology. 1996 Jul;200(1):24-5 [8657919] Radiologe. 2005 Apr;45(4):340-9 [15776265] Int J Cancer. 2000 Jun 20;90(3):138-44 [10900425] Radiology. 1986 Jun;159(3):801-3 [3704160] Health Phys. 1986 Jan;50(1):117-22 [3943961] Radiology. 1985 Jun;155(3):825 [4001386] Lancet. 2004 Jan 31;363(9406):345-51 [15070562] N1 - Last updated - 2017-01-19 ER - TY - JOUR T1 - Quitting among non-treatment-seeking marijuana users: reasons and changes in other substance use. AN - 68674465; 16867925 AB - This study examines the self-reported reasons for quitting marijuana use, changes in other substance use during the quit attempt, and reasons for the resumption of use in 104 non-treatment-seeking adult marijuana smokers. Reasons for quitting were shown to be primarily motivated by concerns about the negative impact of marijuana on health and on self- and social image. The spontaneous quitting of marijuana use is often associated with an increase in the use of legal substances such as alcohol, tobacco, and sleeping aids, but not with the initiation of new substance use. These findings suggest areas for further research on spontaneous recovery from marijuana use. JF - The American journal on addictions AU - Copersino, Marc L AU - Boyd, Susan J AU - Tashkin, Donald P AU - Huestis, Marilyn A AU - Heishman, Stephen J AU - Dermand, John C AU - Simmons, Michael S AU - Gorelick, David A AD - Clinical Pharmacology & Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health & Human Services, Baltimore, Maryland, USA. PY - 2006 SP - 297 EP - 302 VL - 15 IS - 4 SN - 1055-0496, 1055-0496 KW - Coffee KW - 0 KW - Hypnotics and Sedatives KW - Index Medicus KW - United States KW - Motivation KW - Humans KW - Smoking -- psychology KW - Longitudinal Studies KW - Smoking -- epidemiology KW - Comorbidity KW - Recurrence KW - Adult KW - Middle Aged KW - Self Care -- psychology KW - Female KW - Male KW - Alcoholism -- rehabilitation KW - Alcoholism -- epidemiology KW - Marijuana Abuse -- rehabilitation KW - Marijuana Abuse -- psychology KW - Marijuana Abuse -- epidemiology KW - Substance-Related Disorders -- rehabilitation KW - Substance-Related Disorders -- psychology KW - Alcoholism -- psychology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68674465?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+American+journal+on+addictions&rft.atitle=Quitting+among+non-treatment-seeking+marijuana+users%3A+reasons+and+changes+in+other+substance+use.&rft.au=Copersino%2C+Marc+L%3BBoyd%2C+Susan+J%3BTashkin%2C+Donald+P%3BHuestis%2C+Marilyn+A%3BHeishman%2C+Stephen+J%3BDermand%2C+John+C%3BSimmons%2C+Michael+S%3BGorelick%2C+David+A&rft.aulast=Copersino&rft.aufirst=Marc&rft.date=2006-07-01&rft.volume=15&rft.issue=4&rft.spage=297&rft.isbn=&rft.btitle=&rft.title=The+American+journal+on+addictions&rft.issn=10550496&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-05-02 N1 - Date created - 2006-07-26 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Separate RNA-binding surfaces on the multifunctional La protein mediate distinguishable activities in tRNA maturation. AN - 68621801; 16799560 AB - By sequence-specific binding to 3' UUU-OH, the La protein shields precursor (pre)-RNAs from 3' end digestion and is required to protect defective pre-transfer RNAs from decay. Although La is comprised of a La motif and an RNA-recognition motif (RRM), a recent structure indicates that the RRM beta-sheet surface is not involved in UUU-OH recognition, raising questions as to its function. Progressively defective suppressor tRNAs in Schizosaccharomyces pombe reveal differential sensitivities to La and Rrp6p, a 3' exonuclease component of pre-tRNA decay. 3' end protection is compromised by mutations to the La motif but not the RRM surface. The most defective pre-tRNAs require a second activity of La, in addition to 3' protection, that requires an intact RRM surface. The two activities of La in tRNA maturation map to its two conserved RNA-binding surfaces and suggest a modular model that has implications for its other ligands. JF - Nature structural & molecular biology AU - Huang, Ying AU - Bayfield, Mark A AU - Intine, Robert V AU - Maraia, Richard J AD - Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, US National Institutes of Health, 31 Center Dr., Rm. 2A25, Bethesda, Maryland 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 611 EP - 618 VL - 13 IS - 7 SN - 1545-9993, 1545-9993 KW - RNA, Fungal KW - 0 KW - RNA-Binding Proteins KW - Recombinant Proteins KW - Schizosaccharomyces pombe Proteins KW - sla1 protein, S pombe KW - RNA, Transfer KW - 9014-25-9 KW - Index Medicus KW - RNA, Fungal -- genetics KW - Animals KW - Sequence Alignment KW - RNA Processing, Post-Transcriptional -- genetics KW - Conserved Sequence KW - Recombinant Proteins -- metabolism KW - Humans KW - Molecular Sequence Data KW - Suppression, Genetic KW - Amino Acid Sequence KW - Mutagenesis KW - Schizosaccharomyces -- genetics KW - RNA-Binding Proteins -- metabolism KW - RNA-Binding Proteins -- genetics KW - RNA, Transfer -- genetics KW - Schizosaccharomyces pombe Proteins -- genetics KW - Schizosaccharomyces pombe Proteins -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68621801?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+structural+%26+molecular+biology&rft.atitle=Separate+RNA-binding+surfaces+on+the+multifunctional+La+protein+mediate+distinguishable+activities+in+tRNA+maturation.&rft.au=Huang%2C+Ying%3BBayfield%2C+Mark+A%3BIntine%2C+Robert+V%3BMaraia%2C+Richard+J&rft.aulast=Huang&rft.aufirst=Ying&rft.date=2006-07-01&rft.volume=13&rft.issue=7&rft.spage=611&rft.isbn=&rft.btitle=&rft.title=Nature+structural+%26+molecular+biology&rft.issn=15459993&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-25 N1 - Date created - 2006-07-07 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CCR5: no longer a "good for nothing" gene--chemokine control of West Nile virus infection. AN - 68611783; 16753343 AB - The chemokine receptor CCR5 was identified in 1996 as a crucial host factor exploited by HIV for cell entry. CCR5 presumably functions normally in antimicrobial host defense because it generally mediates leukocyte chemotactic responses; however, evidence of antimicrobial functions for CCR5 in humans has been elusive. Recently, genetic analyses in mice and humans have provided strong evidence for the CCR5 control of infection by West Nile virus (WNV), a re-emerging pathogen capable of causing fatal encephalitis. Thus, the same receptor can benefit or harm the host, depending on the virus. Although CCR5 might be a logical target for new drug development in HIV/AIDS, the benefits of blocking CCR5 could carry the cost of an increased risk of WNV disease in co-infected patients. JF - Trends in immunology AU - Lim, Jean K AU - Glass, William G AU - McDermott, David H AU - Murphy, Philip M AD - Molecular Signaling Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 308 EP - 312 VL - 27 IS - 7 SN - 1471-4906, 1471-4906 KW - Anti-HIV Agents KW - 0 KW - CCR5 Receptor Antagonists KW - Receptors, CCR5 KW - Index Medicus KW - Animals KW - Anti-HIV Agents -- therapeutic use KW - HIV Infections -- complications KW - Humans KW - HIV Infections -- immunology KW - HIV Infections -- drug therapy KW - Anti-HIV Agents -- adverse effects KW - West Nile Fever -- complications KW - Receptors, CCR5 -- physiology KW - Receptors, CCR5 -- genetics KW - West Nile Fever -- genetics KW - West Nile Fever -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68611783?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Trends+in+immunology&rft.atitle=CCR5%3A+no+longer+a+%22good+for+nothing%22+gene--chemokine+control+of+West+Nile+virus+infection.&rft.au=Lim%2C+Jean+K%3BGlass%2C+William+G%3BMcDermott%2C+David+H%3BMurphy%2C+Philip+M&rft.aulast=Lim&rft.aufirst=Jean&rft.date=2006-07-01&rft.volume=27&rft.issue=7&rft.spage=308&rft.isbn=&rft.btitle=&rft.title=Trends+in+immunology&rft.issn=14714906&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-21 N1 - Date created - 2006-07-04 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Retrospective assessment of radiation exposure using biological dosimetry: chromosome painting, electron paramagnetic resonance and the glycophorin a mutation assay. AN - 68602993; 16808614 AB - Biological monitoring of dose can contribute important, independent estimates of cumulative radiation exposure in epidemiological studies, especially in studies in which the physical dosimetry is lacking. Three biodosimeters that have been used in epidemiological studies to estimate past radiation exposure from external sources will be highlighted: chromosome painting or FISH (fluorescence in situ hybridization), the glycophorin A somatic mutation assay (GPA), and electron paramagnetic resonance (EPR) with teeth. All three biodosimeters have been applied to A-bomb survivors, Chernobyl clean-up workers, and radiation workers. Each biodosimeter has unique advantages and limitations depending upon the level and type of radiation exposure. Chromosome painting has been the most widely applied biodosimeter in epidemiological studies of past radiation exposure, and results of these studies provide evidence that dose-related translocations persist for decades. EPR tooth dosimetry has been used to validate dose models of acute and chronic radiation exposure, although the present requirement of extracted teeth has been a disadvantage. GPA has been correlated with physically based radiation dose after high-dose, acute exposures but not after low-dose, chronic exposures. Interindividual variability appears to be a limitation for both chromosome painting and GPA. Both of these techniques can be used to estimate the level of past radiation exposure to a population, whereas EPR can provide individual dose estimates of past exposure. This paper will review each of these three biodosimeters and compare their application in selected epidemiological studies. JF - Radiation research AU - Kleinerman, R A AU - Romanyukha, A A AU - Schauer, D A AU - Tucker, J D AD - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20852, USA. kleinerr@exchange.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 287 EP - 302 VL - 166 IS - 1 Pt 2 SN - 0033-7587, 0033-7587 KW - GYPA protein, human KW - 0 KW - Glycophorin KW - Radioisotopes KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Risk Factors KW - Humans KW - Body Burden KW - Environmental Exposure -- analysis KW - Retrospective Studies KW - Risk Assessment -- methods KW - Biological Assay -- methods KW - Electron Spin Resonance Spectroscopy -- methods KW - Glycophorin -- genetics KW - Radiation Monitoring -- methods KW - DNA Mutational Analysis -- methods KW - Radioisotopes -- analysis KW - Chromosome Painting -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68602993?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Retrospective+assessment+of+radiation+exposure+using+biological+dosimetry%3A+chromosome+painting%2C+electron+paramagnetic+resonance+and+the+glycophorin+a+mutation+assay.&rft.au=Kleinerman%2C+R+A%3BRomanyukha%2C+A+A%3BSchauer%2C+D+A%3BTucker%2C+J+D&rft.aulast=Kleinerman&rft.aufirst=R&rft.date=2006-07-01&rft.volume=166&rft.issue=1+Pt+2&rft.spage=287&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Molecular genetics of addiction vulnerability. AN - 68602453; 16815213 AB - Classical genetic studies document strong complex genetic contributions to abuse of multiple addictive substances, to mnemonic processes that are likely to include those involved in substance dependence, and to the volumes of brain gray matter in regions that are likely to contribute to mnemonic/cognitive and to addictive processes. The working idea that these three heritable phenotypes are likely to share some of the same complex genetic underpinnings is presented. This review contains association-based molecular genetic studies of addiction that largely derive from my laboratory and their fit with linkage data from other laboratories. These combined results now identify many of the loci and genes that contain allelic variants that are likely to provide the heritable components of human addiction vulnerability. These data are also likely to have broad implications for neurotherapeutics. Drugs with potential abuse liabilities are widely used for indications that include pain, anxiety, sleep, seizure, and attentional disorders. There is increasing nonmedical use of these prescribed substances. Increasing information about addiction vulnerability gene variants should help to improve management of risks of dependence in individuals who receive such therapeutics. In addition, since mnemonic components that correlate well with individual differences in brain regional volumes are likely to play major roles in addiction processes, many addiction vulnerability genes are also good candidates to contribute to individual differences in mnemonic processes. Recently elucidation of addiction-associated haplotypes for the "cell adhesion" NrCAM gene illustrate several of these points. JF - NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics AU - Uhl, George R AD - Molecular Neurobiology Branch, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA. guhl@intra.nida.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 295 EP - 301 VL - 3 IS - 3 SN - 1545-5343, 1545-5343 KW - Index Medicus KW - Animals KW - Humans KW - Genetic Predisposition to Disease KW - Molecular Biology -- methods KW - Behavior, Addictive -- genetics KW - Substance-Related Disorders -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68602453?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroRx+%3A+the+journal+of+the+American+Society+for+Experimental+NeuroTherapeutics&rft.atitle=Molecular+genetics+of+addiction+vulnerability.&rft.au=Uhl%2C+George+R&rft.aulast=Uhl&rft.aufirst=George&rft.date=2006-07-01&rft.volume=3&rft.issue=3&rft.spage=295&rft.isbn=&rft.btitle=&rft.title=NeuroRx+%3A+the+journal+of+the+American+Society+for+Experimental+NeuroTherapeutics&rft.issn=15455343&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-07-03 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Neuron. 2000 Mar;25(3):515-32 [10774721] Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):844-53 [16894614] Behav Genet. 1999 Nov;29(6):473-9 [10857252] Alcohol Clin Exp Res. 2000 Jul;24(7):933-45 [10923994] Arch Gen Psychiatry. 2000 Sep;57(9):886-92 [10986552] J Cell Biol. 2001 Sep 17;154(6):1259-73 [11564762] Twin Res. 2001 Feb;4(1):48-56 [11665325] Am J Hum Genet. 2001 Dec;69(6):1290-300 [11704927] Hippocampus. 2001;11(6):754-62 [11811670] Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3176-81 [11867730] Trends Genet. 2002 Aug;18(8):420-5 [12142011] Neurobiol Learn Mem. 2002 Nov;78(3):637-47 [12559841] Twin Res. 2003 Apr;6(2):131-9 [12723999] Drug Alcohol Depend. 2003 Jun 5;70(3):295-307 [12757967] Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9440-5 [12883005] BMC Genet. 2003;4 Suppl 1:S101 [14975169] BMC Genet. 2003;4 Suppl 1:S103 [14975171] BMC Genet. 2003;4 Suppl 1:S104 [14975172] Arch Gen Psychiatry. 2004 Mar;61(3):223-9 [14993109] Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):94-101 [15211640] Neuropharmacology. 2004;47 Suppl 1:140-7 [15464133] Arch Gen Psychiatry. 1991 Jan;48(1):19-28 [1984758] Am J Med Genet. 1996 Sep 20;67(5):473-7 [8886164] Arch Gen Psychiatry. 1997 Feb;54(2):178-84 [9040286] Am J Med Genet. 1998 May 8;81(3):207-15 [9603606] Am J Med Genet. 1998 May 8;81(3):216-21 [9603607] Arch Gen Psychiatry. 1998 Nov;55(11):967-72 [9819064] Neuropsychopharmacology. 1999 Jan;20(1):3-9 [9885780] Br J Psychiatry. 1998 Oct;173:345-50 [9926041] Mol Psychiatry. 1999 Mar;4(2):129-44 [10208445] Arch Gen Psychiatry. 1999 Jul;56(7):655-61 [10401514] Am J Med Genet. 1999 Aug 20;88(4):391-7 [10402507] Ann N Y Acad Sci. 2004 Oct;1025:1-13 [15542694] Eur J Hum Genet. 2005 Feb;13(2):198-207 [15523497] Science. 2005 Apr 15;308(5720):421-4 [15761121] Pharmacogenomics J. 2005;5(3):166-72 [15724146] Am J Med Genet B Neuropsychiatr Genet. 2005 Jul 5;136B(1):45-52 [15909294] Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11864-9 [16091475] Curr Psychiatry Rep. 2005 Oct;7(5):337-43 [16216151] Trends Neurosci. 2006 Jan;29(1):21-9 [16337696] Neuropsychopharmacology. 2006 Mar;31(3):572-84 [16123759] NeuroRx. 2006 Jul;3(3):373-83 [16815220] Br J Psychiatry. 1999 Oct;175:351-6 [10789303] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Uses of dosimetry in radiation epidemiology. AN - 68601056; 16808601 JF - Radiation research AU - Simon, Steven L AU - Kleinerman, Ruth A AU - Ron, Elaine AU - Bouville, André AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ssimon@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 125 EP - 127 VL - 166 IS - 1 Pt 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Risk Factors KW - Humans KW - Radiometry -- instrumentation KW - Epidemiologic Methods KW - Radiation Injuries -- epidemiology KW - Risk Assessment -- methods KW - Radiometry -- methods KW - Epidemiologic Measurements UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68601056?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Uses+of+dosimetry+in+radiation+epidemiology.&rft.au=Simon%2C+Steven+L%3BKleinerman%2C+Ruth+A%3BRon%2C+Elaine%3BBouville%2C+Andr%C3%A9&rft.aulast=Simon&rft.aufirst=Steven&rft.date=2006-07-01&rft.volume=166&rft.issue=1+Pt+2&rft.spage=125&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Dosimetry for epidemiological studies: learning from the past, looking to the future. AN - 68600737; 16808617 JF - Radiation research AU - Simon, Steven L AU - Bouville, André AU - Kleinerman, Ruth AU - Ron, Elaine AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. ssimon@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 313 EP - 318 VL - 166 IS - 1 Pt 2 SN - 0033-7587, 0033-7587 KW - Radioisotopes KW - 0 KW - Index Medicus KW - Space life sciences KW - Radiation Dosage KW - Relative Biological Effectiveness KW - Computer Simulation KW - Risk Factors KW - Humans KW - Body Burden KW - Models, Biological KW - Occupational Exposure -- analysis KW - Radiometry -- trends KW - Epidemiologic Studies KW - Neoplasms, Radiation-Induced -- epidemiology KW - Radioisotopes -- analysis KW - Risk Assessment -- methods KW - Radiometry -- methods KW - Risk Assessment -- trends UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68600737?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Dosimetry+for+epidemiological+studies%3A+learning+from+the+past%2C+looking+to+the+future.&rft.au=Simon%2C+Steven+L%3BBouville%2C+Andr%C3%A9%3BKleinerman%2C+Ruth%3BRon%2C+Elaine&rft.aulast=Simon&rft.aufirst=Steven&rft.date=2006-07-01&rft.volume=166&rft.issue=1+Pt+2&rft.spage=313&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Estimating historical radiation doses to a cohort of U.S. radiologic technologists. AN - 68600541; 16808606 AB - Data have been collected and physical and statistical models have been constructed to estimate unknown occupational radiation doses among 90,000 members of the U.S. Radiologic Technologists cohort who responded to a baseline questionnaire during the mid-1980s. Since the availability of radiation dose data differed by calendar period, different models were developed and applied for years worked before 1960, 1960- 1976 and 1977-1984. The dose estimation used available film-badge measurements (approximately 350,000) for individual cohort members, information provided by the technologists on their work history and protection practices, and measurement and other data derived from the literature. The dosimetry model estimates annual and cumulative occupational badge doses (personal dose equivalent) for each technologist for each year worked from 1916 through 1984 as well as absorbed doses to organs and tissues including bone marrow, female breast, thyroid, ovary, testes, lung and skin. Assumptions have been made about critical variables including average energy of X rays, use of protective aprons, position of film badges, and minimum detectable doses. Uncertainty of badge and organ doses was characterized for each year of each technologist's working career. Monte Carlo methods were used to generate estimates of cumulative organ doses for preliminary cancer risk analyses. The models and predictions presented here, while continuing to be modified and improved, represent one of the most comprehensive dose reconstructions undertaken to date for a large cohort of medical radiation workers. JF - Radiation research AU - Simon, Steven L AU - Weinstock, Robert M AU - Doody, Michele Morin AU - Neton, James AU - Wenzl, Thurman AU - Stewart, Patricia AU - Mohan, Aparna K AU - Yoder, R Craig AU - Hauptmann, Michael AU - Freedman, D Michal AU - Cardarelli, John AU - Feng, H Amy AU - Bouville, André AU - Linet, Martha AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health, Bethesda, Maryland, USA. ssimon@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 174 EP - 192 VL - 166 IS - 1 Pt 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Sensitivity and Specificity KW - Radiation Dosage KW - Computer Simulation KW - Reproducibility of Results KW - Body Burden KW - Humans KW - Aged KW - Organ Specificity KW - Models, Biological KW - Relative Biological Effectiveness KW - Aged, 80 and over KW - Risk Factors KW - Adult KW - Cohort Studies KW - Middle Aged KW - Adolescent KW - United States -- epidemiology KW - Female KW - Male KW - Occupational Exposure -- statistics & numerical data KW - Radiation Monitoring -- methods KW - Technology, Radiologic -- statistics & numerical data KW - Neoplasms, Radiation-Induced -- epidemiology KW - Occupational Diseases -- epidemiology KW - Risk Assessment -- methods KW - Radiation Monitoring -- statistics & numerical data KW - Radiation Monitoring -- instrumentation KW - Occupational Exposure -- analysis UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68600541?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=Estimating+historical+radiation+doses+to+a+cohort+of+U.S.+radiologic+technologists.&rft.au=Simon%2C+Steven+L%3BWeinstock%2C+Robert+M%3BDoody%2C+Michele+Morin%3BNeton%2C+James%3BWenzl%2C+Thurman%3BStewart%2C+Patricia%3BMohan%2C+Aparna+K%3BYoder%2C+R+Craig%3BHauptmann%2C+Michael%3BFreedman%2C+D+Michal%3BCardarelli%2C+John%3BFeng%2C+H+Amy%3BBouville%2C+Andr%C3%A9%3BLinet%2C+Martha&rft.aulast=Simon&rft.aufirst=Steven&rft.date=2006-07-01&rft.volume=166&rft.issue=1+Pt+2&rft.spage=174&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The chornobyl accident: estimation of radiation doses received by the Baltic and Ukrainian cleanup workers. AN - 68597897; 16808604 AB - During the first day after the explosion, the Chornobyl accident of April 26, 1986 exposed a few hundred emergency workers to high dose levels ranging up to 16 Gy, resulting in acute radiation syndrome. Subsequently, several hundred thousand cleanup workers were sent to the Chornobyl power plant to mitigate the consequences of the accident. Depending on the nature of the work to be carried out, the cleanup workers were sent for periods ranging from several minutes to several months. The average dose from external radiation exposure that was received by the cleanup workers was about 170 mGy in 1986 and decreased from year to year. The radiation exposure was mainly due to external irradiation from gamma-ray-emitting radionuclides and was relatively homogeneous over all organs and tissues of the body. To assess the possible health consequences of external irradiation at relatively low dose rates, the U.S. National Cancer Institute is involved in two studies of Chornobyl cleanup workers: (1) a study of cancer incidence and thyroid disease among Estonian, Latvian and Lithuanian workers, and (2) a study of leukemia and other related blood diseases among Ukrainian workers. After an overview of the sources of exposure and of the radiation doses received by the cleanup workers, a description of the efforts made to estimate individual doses in the Baltic and Ukrainian studies is presented. JF - Radiation research AU - Bouville, André AU - Chumak, Vadim V AU - Inskip, Peter D AU - Kryuchkov, Viktor AU - Luckyanov, Nickolas AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, DHHS, Bethesda, Maryland 20892, USA. bouvilla@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 158 EP - 167 VL - 166 IS - 1 Pt 2 SN - 0033-7587, 0033-7587 KW - Index Medicus KW - Space life sciences KW - Ukraine -- epidemiology KW - Radiation Dosage KW - Radioactive Hazard Release -- statistics & numerical data KW - Risk Factors KW - Humans KW - Power Plants -- statistics & numerical data KW - Baltic States -- epidemiology KW - Occupational Exposure -- statistics & numerical data KW - Chernobyl Nuclear Accident KW - Radiation Monitoring -- methods KW - Neoplasms, Radiation-Induced -- epidemiology KW - Environmental Exposure -- analysis KW - Decontamination -- statistics & numerical data KW - Risk Assessment -- methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68597897?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+research&rft.atitle=The+chornobyl+accident%3A+estimation+of+radiation+doses+received+by+the+Baltic+and+Ukrainian+cleanup+workers.&rft.au=Bouville%2C+Andr%C3%A9%3BChumak%2C+Vadim+V%3BInskip%2C+Peter+D%3BKryuchkov%2C+Viktor%3BLuckyanov%2C+Nickolas&rft.aulast=Bouville&rft.aufirst=Andr%C3%A9&rft.date=2006-07-01&rft.volume=166&rft.issue=1+Pt+2&rft.spage=158&rft.isbn=&rft.btitle=&rft.title=Radiation+research&rft.issn=00337587&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-16 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Genetic organization and hypoxic activation of the Kaposi's sarcoma-associated herpesvirus ORF34-37 gene cluster. AN - 68593715; 16809309 AB - Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi's sarcoma (KS) and primary effusion lymphoma (PEL). We previously reported that hypoxia activates KSHV lytic replication and that the promoter for open reading frame 34 (ORF34) contains a functional hypoxia-responsive element (HRE). ORF34 is part of a cluster of lytic genes (ORF34-37) that includes ORF36, a phosphotransferase, and ORF37, a shutoff exonuclease. Rapid amplification of cDNA ends analysis revealed that they share a common polyadenylation signal but have two start sites. Two transcripts were identified, one 3.4 kb encoding ORF35-37, and the other 4.2 kb encoding ORF34 and also having coding potential for ORF35-37. Exposure of PEL cell lines to hypoxia induced messages of lengths consistent with those of these transcripts. Reporter assays with Hep3B cells showed activation of both transcripts by hypoxia. The ORF34-37 promoter region has six consensus HREs. Sequential deletion, site-directed mutagenesis experiments, and Northern blot analysis of RNA produced by constructs indicated that the second HRE (HRE-2) plays a critical role in the hypoxic activation of both RNA transcripts. The ORF35-37 transcript was upregulated by cotransfected hypoxia-inducible factor (HIF). Electrophoretic mobility shift assays demonstrated that HRE-2 and ancillary sequences bind and compete for HIF with hypoxic Hep3B nuclear extract. The activation of this gene cluster by hypoxia may have implications for the pathogenesis of PEL and KS. Moreover, the activation of ORF36 by hypoxia might be exploited to develop targeted therapy for PEL, which arises in a hypoxic environment (pleural effusions). JF - Journal of virology AU - Haque, Muzammel AU - Wang, Victoria AU - Davis, David A AU - Zheng, Zhi-Ming AU - Yarchoan, Robert AD - HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1868, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 7037 EP - 7051 VL - 80 IS - 14 SN - 0022-538X, 0022-538X KW - Basic Helix-Loop-Helix Transcription Factors KW - 0 KW - RNA, Messenger KW - RNA, Viral KW - Viral Proteins KW - Phosphotransferases KW - EC 2.7.- KW - Exonucleases KW - EC 3.1.- KW - Index Medicus KW - Viral Proteins -- genetics KW - Phosphotransferases -- genetics KW - Exonucleases -- genetics KW - Humans KW - Transcription, Genetic -- genetics KW - Sarcoma, Kaposi -- genetics KW - Up-Regulation -- genetics KW - Basic Helix-Loop-Helix Transcription Factors -- genetics KW - RNA, Messenger -- genetics KW - Mutagenesis, Site-Directed KW - Base Sequence KW - Cell Hypoxia -- genetics KW - Lymphoma -- genetics KW - Sarcoma, Kaposi -- virology KW - RNA, Viral -- genetics KW - Lymphoma -- virology KW - Cell Line KW - Sequence Deletion KW - Cell-Free System KW - Multigene Family -- genetics KW - Virus Activation -- genetics KW - Herpesvirus 8, Human -- physiology KW - Response Elements -- genetics KW - Gene Expression Regulation, Viral -- genetics KW - Open Reading Frames -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68593715?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+virology&rft.atitle=Genetic+organization+and+hypoxic+activation+of+the+Kaposi%27s+sarcoma-associated+herpesvirus+ORF34-37+gene+cluster.&rft.au=Haque%2C+Muzammel%3BWang%2C+Victoria%3BDavis%2C+David+A%3BZheng%2C+Zhi-Ming%3BYarchoan%2C+Robert&rft.aulast=Haque&rft.aufirst=Muzammel&rft.date=2006-07-01&rft.volume=80&rft.issue=14&rft.spage=7037&rft.isbn=&rft.btitle=&rft.title=Journal+of+virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-30 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Nat Cell Biol. 2000 Jul;2(7):423-7 [10878807] J Biol Chem. 2000 Jul 14;275(28):21048-54 [10777486] J Biol Chem. 2000 Aug 18;275(33):25733-41 [10823831] Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10430-5 [10973499] J Biol Chem. 2001 Jan 19;276(3):2292-8 [11056166] J Virol. 2001 Mar;75(6):2938-45 [11222719] Science. 2001 Apr 20;292(5516):464-8 [11292862] Science. 2001 Apr 20;292(5516):468-72 [11292861] Blood. 2001 May 15;97(10):3244-50 [11342455] Nature. 1999 May 20;399(6733):271-5 [10353251] J Biol Chem. 1999 Aug 20;274(34):24147-52 [10446188] J Virol. 1999 Nov;73(11):9348-61 [10516043] J Virol. 2000 Nov;74(21):10187-93 [11024147] J Virol. 2001 Feb;75(4):1798-807 [11160678] J Virol. 2001 Feb;75(4):1857-63 [11160684] J Virol. 2001 Feb;75(4):1864-9 [11160685] J Virol. 2004 Dec;78(24):13637-52 [15564474] Cancer Res. 2005 Apr 15;65(8):3299-306 [15833863] Annu Rev Cell Dev Biol. 1999;15:551-78 [10611972] J Virol. 2000 Mar;74(6):2867-75 [10684303] J Gen Virol. 2000 Apr;81(Pt 4):1067-71 [10725434] Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9630-5 [11504942] Science. 2002 Feb 1;295(5556):807-8 [11823627] Science. 2002 Feb 1;295(5556):858-61 [11823643] Nat Rev Cancer. 2002 Jan;2(1):38-47 [11902584] J Biol Chem. 2002 Apr 26;277(17):14547-56 [11832484] Genes Dev. 2002 Jun 15;16(12):1466-71 [12080085] Blood. 2002 Sep 1;100(5):1919-21 [12176919] Science. 2002 Nov 15;298(5597):1432-5 [12434062] J Biol Chem. 2002 Dec 6;277(49):47014-21 [12354771] Rev Med Virol. 2003 May-Jun;13(3):173-84 [12740832] J Biol Chem. 2003 May 30;278(22):19575-8 [12639949] J Virol. 2003 Jun;77(12):6761-8 [12767996] Mol Cell Biol. 2003 Dec;23(24):9361-74 [14645546] J Virol. 2004 Mar;78(5):2609-14 [14963167] Mol Interv. 2002 Jul;2(4):229-43 [14993394] Mol Cell. 2004 Mar 12;13(5):713-23 [15023341] Physiology (Bethesda). 2004 Aug;19:176-82 [15304631] J Biol Chem. 2004 Sep 10;279(37):38325-30 [15247271] J Lab Clin Med. 1971 Dec;78(6):1006 [5131833] South Med J. 1981 May;74(5):585-9 [6787716] Mol Cell Biol. 1992 Dec;12(12):5447-54 [1448077] Proc Natl Acad Sci U S A. 1993 May 1;90(9):3928-32 [8387202] J Biol Chem. 1993 Oct 15;268(29):21513-8 [8408001] Science. 1994 Dec 16;266(5192):1865-9 [7997879] N Engl J Med. 1995 May 4;332(18):1186-91 [7700311] Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4 [7539918] Blood. 1995 Aug 15;86(4):1276-80 [7632932] Nat Med. 1995 Jul;1(7):707-8 [7585156] J Virol. 1996 Jan;70(1):549-58 [8523568] Nat Med. 1996 Mar;2(3):342-6 [8612236] J Biol Chem. 1996 Jul 26;271(30):17771-8 [8663540] Mol Cell Biol. 1996 Sep;16(9):4604-13 [8756616] Blood. 1996 Oct 1;88(7):2648-54 [8839859] Am J Physiol. 1996 Oct;271(4 Pt 1):C1172-80 [8897823] J Biol Chem. 1996 Dec 20;271(51):32529-37 [8955077] Proc Natl Acad Sci U S A. 1996 Dec 10;93(25):14862-7 [8962146] J Virol. 1997 Jan;71(1):314-24 [8985352] Genes Dev. 1997 Jan 1;11(1):72-82 [9000051] Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4273-8 [9113979] Mech Dev. 1997 Apr;63(1):51-60 [9178256] J Biol Chem. 1997 Sep 5;272(36):22642-7 [9278421] Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7987-92 [9653127] Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10866-71 [9724796] J Virol. 1998 Oct;72(10):8309-15 [9733875] Virology. 1998 Sep 15;249(1):140-9 [9740785] Gene Expr. 1998;7(3):205-13 [9840812] J Virol. 1999 Feb;73(2):1438-46 [9882349] J Gen Virol. 1999 Jan;80 ( Pt 1):83-90 [9934688] J Virol. 1999 Mar;73(3):1909-17 [9971770] J Biol Chem. 1999 Mar 5;274(10):6519-25 [10037745] Virology. 1999 Apr 25;257(1):84-94 [10208923] J Virol. 1999 Jun;73(6):4786-93 [10233939] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The role of UGT1A1*28 polymorphism in the pharmacodynamics and pharmacokinetics of irinotecan in patients with metastatic colorectal cancer. AN - 68591883; 16809730 AB - UGT1A1*28 polymorphism has been associated with decreased glucuronidation of SN38, the active metabolite of irinotecan. This could increase toxicity with this agent. In a prospective study, 250 metastatic colorectal cancer patients were treated with irinotecan, fluorouracil, and leucovorin as first-line treatment. UGT1A1*28 polymorphism was investigated with respect to the distribution of hematologic and nonhematologic toxicity, objective response rate, and survival. Pharmacokinetics was investigated in a subgroup of patients (71 of 250) who had been analyzed with respect to toxicity and efficacy. UGT1A1*28 polymorphism was associated with a higher risk of grade 3 to 4 hematologic toxicity (odds ratio [OR], 8.63; 95% CI, 1.31 to 56.55), which was only relevant for the first cycle, and was not seen throughout the whole treatment period for patients with both variant alleles TA7/TA7 compared with wild-type TA6/TA6. The response rate was also higher in TA7/TA7 patients (OR, 0.32; 95% CI, 0.12 to 0.86) compared with TA6/TA6. A nonsignificant survival advantage was observed for TA7/TA7 when compared with TA6/TA6 patients (hazard ratio, 0.81; 95% CI, 0.45 to 1.44). Higher response rates were explained by a different pharmacokinetics with higher biliary index [irinotecan area under the curve (AUC)x(SN38 AUC/SN38G AUC)] and lower glucuronidation ratio (SN38G AUC/SN38 AUC) associated with the TA7/TA7 genotype and a higher response rate, indicating that the polymorphism is functionally relevant. The results indicate that UGT1A1*28 polymorphism is of some relevance to toxicity; however, it is less important than discussed in previous smaller trials. In particular, the possibility of a dose reduction for irinotecan in patients with a UGT1A1*28 polymorphism is not supported by the result of this analysis. JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology AU - Toffoli, Giuseppe AU - Cecchin, Erika AU - Corona, Giuseppe AU - Russo, Antonio AU - Buonadonna, Angela AU - D'Andrea, Mario AU - Pasetto, Lara Maria AU - Pessa, Sergio AU - Errante, Domenico AU - De Pangher, Vincenzo AU - Giusto, Mauro AU - Medici, Michele AU - Gaion, Fernando AU - Sandri, Paolo AU - Galligioni, Enzo AU - Bonura, Salvatore AU - Boccalon, Massimo AU - Biason, Paola AU - Frustaci, Sergio AD - Experimental and Clinical Pharmacology Unit, Medical Oncology unit of Centro di Riferimento Oncologico, National Cancer Institute, via Pedemontana Occidentale, 12, 33081, Aviano, Italy. gtoffoli@cro.it Y1 - 2006/07/01/ PY - 2006 DA - 2006 Jul 01 SP - 3061 EP - 3068 VL - 24 IS - 19 KW - irinotecan KW - 0H43101T0J KW - Glucuronosyltransferase KW - EC 2.4.1.17 KW - Leucovorin KW - Q573I9DVLP KW - Fluorouracil KW - U3P01618RT KW - Camptothecin KW - XT3Z54Z28A KW - Index Medicus KW - Genotype KW - Fluorouracil -- administration & dosage KW - Prospective Studies KW - Leucovorin -- administration & dosage KW - Humans KW - Adult KW - Treatment Outcome KW - Neoplasm Metastasis KW - Aged KW - Middle Aged KW - Male KW - Female KW - Glucuronosyltransferase -- genetics KW - Camptothecin -- pharmacology KW - Polymorphism, Genetic KW - Colorectal Neoplasms -- pathology KW - Camptothecin -- pharmacokinetics KW - Camptothecin -- analogs & derivatives KW - Glucuronosyltransferase -- metabolism KW - Antineoplastic Combined Chemotherapy Protocols -- adverse effects KW - Camptothecin -- adverse effects KW - Antineoplastic Combined Chemotherapy Protocols -- therapeutic use KW - Colorectal Neoplasms -- drug therapy UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68591883?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.atitle=The+role+of+UGT1A1*28+polymorphism+in+the+pharmacodynamics+and+pharmacokinetics+of+irinotecan+in+patients+with+metastatic+colorectal+cancer.&rft.au=Toffoli%2C+Giuseppe%3BCecchin%2C+Erika%3BCorona%2C+Giuseppe%3BRusso%2C+Antonio%3BBuonadonna%2C+Angela%3BD%27Andrea%2C+Mario%3BPasetto%2C+Lara+Maria%3BPessa%2C+Sergio%3BErrante%2C+Domenico%3BDe+Pangher%2C+Vincenzo%3BGiusto%2C+Mauro%3BMedici%2C+Michele%3BGaion%2C+Fernando%3BSandri%2C+Paolo%3BGalligioni%2C+Enzo%3BBonura%2C+Salvatore%3BBoccalon%2C+Massimo%3BBiason%2C+Paola%3BFrustaci%2C+Sergio&rft.aulast=Toffoli&rft.aufirst=Giuseppe&rft.date=2006-07-01&rft.volume=24&rft.issue=19&rft.spage=3061&rft.isbn=&rft.btitle=&rft.title=Journal+of+clinical+oncology+%3A+official+journal+of+the+American+Society+of+Clinical+Oncology&rft.issn=1527-7755&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-19 N1 - Date created - 2006-06-30 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke. AN - 68588774; 16763191 AB - Early thrombolytic therapy with intravenous recombinant tissue plasminogen activator (rtPA) improves clinical outcome in acute ischemic stroke (AIS), but impaired endogenous fibrinolysis, thrombin generation, and vascular injury may hamper the efficacy of thrombolysis. We investigated in an exploratory, post hoc analysis the relationship between hemostatic markers and clinical outcomes among patients included in the National Institute of Neurological Disorders and Stroke (NINDS) rtPA Stroke Study. Tissue plasminogen activator (tPA) antigen, thrombin-antithrombin complex (TAT), soluble thrombomodulin, and fibrinogen levels were measured in patients with AIS included in the NINDS rtPA Stroke Study from plasma samples collected at baseline, at 2 hours after treatment, and after 24 hours. TAT and tPA antigen levels peaked at 2 hours selectively in the rtPA treatment group, whereas fibrinogen levels dropped at 2 hours and remained low after 24 hours (P<0.0001 for interaction effects between time and treatment). At 24 hours, higher levels of tPA antigen were associated with a lower chance of favorable outcome (odds ratio [OR]=0.34; 95% CI, 0.14 to 0.82) selectively in the rtPA group, and higher levels of TAT (OR=1.72; 95% CI, 1.26 to 2.34) in the entire cohort and of thrombomodulin selectively in the rtPA group (OR=4.45; 95% CI, 1.26 to 15.67) were associated with higher 3-month mortality. Hemostatic activation after AIS appears to be independently associated with clinical outcome in patients treated with rtPA. However, because we have tested for multiple associations, some may have been identified by chance alone and require further confirmatory studies. On the basis of this exploratory analysis, there is a rationale to investigate the safety and efficacy of protocols in which rtPA is complemented by agents that are antithrombotic and enhance fibrinolysis. JF - Stroke AU - Tanne, David AU - Macko, Richard F AU - Lin, Yan AU - Tilley, Barbara C AU - Levine, Steven R AU - NINDS rtPA Stroke Study Group AD - Stroke Center, Department of Neurology, Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel. tanne@post.tau.ac.il. ; NINDS rtPA Stroke Study Group Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1798 EP - 1804 VL - 37 IS - 7 KW - Fibrinolytic Agents KW - 0 KW - Recombinant Proteins KW - Thrombomodulin KW - antithrombin III-protease complex KW - Antithrombin III KW - 9000-94-6 KW - Fibrinogen KW - 9001-32-5 KW - Peptide Hydrolases KW - EC 3.4.- KW - Thrombin KW - EC 3.4.21.5 KW - Tissue Plasminogen Activator KW - EC 3.4.21.68 KW - Index Medicus KW - Acute Disease KW - Fibrinogen -- analysis KW - Multicenter Studies as Topic KW - Randomized Controlled Trials as Topic KW - Peptide Hydrolases -- analysis KW - Double-Blind Method KW - Humans KW - Thrombin -- biosynthesis KW - Antithrombin III -- analysis KW - Thrombomodulin -- blood KW - Cohort Studies KW - Confounding Factors (Epidemiology) KW - Treatment Outcome KW - Fibrinolysis -- drug effects KW - Fibrinolytic Agents -- therapeutic use KW - Tissue Plasminogen Activator -- analysis KW - Tissue Plasminogen Activator -- therapeutic use KW - Recombinant Proteins -- pharmacology KW - Brain Ischemia -- drug therapy KW - Tissue Plasminogen Activator -- pharmacology KW - Hemostasis -- drug effects KW - Fibrinolytic Agents -- pharmacology KW - Thrombolytic Therapy -- adverse effects KW - Recombinant Proteins -- therapeutic use KW - Brain Ischemia -- blood UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68588774?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stroke&rft.atitle=Hemostatic+activation+and+outcome+after+recombinant+tissue+plasminogen+activator+therapy+for+acute+ischemic+stroke.&rft.au=Tanne%2C+David%3BMacko%2C+Richard+F%3BLin%2C+Yan%3BTilley%2C+Barbara+C%3BLevine%2C+Steven+R%3BNINDS+rtPA+Stroke+Study+Group&rft.aulast=Tanne&rft.aufirst=David&rft.date=2006-07-01&rft.volume=37&rft.issue=7&rft.spage=1798&rft.isbn=&rft.btitle=&rft.title=Stroke&rft.issn=1524-4628&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-07-18 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Anandamide administration alone and after inhibition of fatty acid amide hydrolase (FAAH) increases dopamine levels in the nucleus accumbens shell in rats. AN - 68587844; 16805835 AB - Although endogenous cannabinoid systems have been implicated in the modulation of the rewarding effects of abused drugs and food, little is known about the direct effects of endogenous ligands for cannabinoid receptors on brain reward processes. Here we show for the first time that the intravenous administration of anandamide, an endogenous ligand for cannabinoid receptors, and its longer-lasting synthetic analog methanandamide, increase the extracellular dopamine levels in the nucleus accumbens shell of awake, freely moving rats, an effect characteristic of most drugs abused by humans. Anandamide produced two distinctly different effects on dopamine levels: (1) a rapid, transient increase that was blocked by the cannabinoid CB1 receptor antagonist rimonabant, but not by the vanilloid VR1 receptor antagonist capsazepine, and was magnified and prolonged by the fatty acid amide hydrolase (FAAH) enzyme inhibitor, URB597; (2) a smaller delayed and long-lasting increase, not sensitive to CB1, VR1 or FAAH blockade. Both effects were blocked by infusing either tetrodotoxin (TTX, 1 microm) or calcium-free Ringer's solution through the microdialysis probe, demonstrating that they were dependent on the physiologic activation of dopaminergic neurotransmission. Thus, these results indicate that anandamide, through the activation of the mesolimbic dopaminergic system, participates in the signaling of brain reward processes. JF - Journal of neurochemistry AU - Solinas, Marcello AU - Justinova, Zuzana AU - Goldberg, Steven R AU - Tanda, Gianluigi AD - Preclinical Pharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 408 EP - 419 VL - 98 IS - 2 SN - 0022-3042, 0022-3042 KW - Arachidonic Acids KW - 0 KW - Benzamides KW - Cannabinoids KW - Carbamates KW - Endocannabinoids KW - Enzyme Inhibitors KW - Polyunsaturated Alkamides KW - Receptor, Cannabinoid, CB1 KW - TRPV Cation Channels KW - TRPV1 receptor KW - cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester KW - Tetrodotoxin KW - 4368-28-9 KW - Amidohydrolases KW - EC 3.5.- KW - fatty-acid amide hydrolase KW - EC 3.5.1.- KW - Calcium KW - SY7Q814VUP KW - anandamide KW - UR5G69TJKH KW - Dopamine KW - VTD58H1Z2X KW - Index Medicus KW - Carbamates -- pharmacology KW - Animals KW - TRPV Cation Channels -- drug effects KW - Synaptic Transmission -- drug effects KW - Receptor, Cannabinoid, CB1 -- drug effects KW - Cannabinoids -- pharmacology KW - Microdialysis KW - Rats KW - Rats, Sprague-Dawley KW - Benzamides -- pharmacology KW - Calcium -- physiology KW - Data Interpretation, Statistical KW - Tetrodotoxin -- pharmacology KW - Male KW - Nucleus Accumbens -- drug effects KW - Nucleus Accumbens -- metabolism KW - Enzyme Inhibitors -- pharmacology KW - Dopamine -- metabolism KW - Amidohydrolases -- antagonists & inhibitors KW - Arachidonic Acids -- pharmacology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68587844?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurochemistry&rft.atitle=Anandamide+administration+alone+and+after+inhibition+of+fatty+acid+amide+hydrolase+%28FAAH%29+increases+dopamine+levels+in+the+nucleus+accumbens+shell+in+rats.&rft.au=Solinas%2C+Marcello%3BJustinova%2C+Zuzana%3BGoldberg%2C+Steven+R%3BTanda%2C+Gianluigi&rft.aulast=Solinas&rft.aufirst=Marcello&rft.date=2006-07-01&rft.volume=98&rft.issue=2&rft.spage=408&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurochemistry&rft.issn=00223042&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-29 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Expression of heregulin by mouse mammary tumor cells: role in activation of ErbB receptors. AN - 68581239; 16482517 AB - The inappropriate activation of one or more members of the ErbB family of receptor tyrosine kinases [ErbB-1 (EGFR), ErbB-2, ErbB-3, ErbB-4] has been linked with oncogenesis. ErbB-2 is frequently coexpressed with ErbB-3 in breast cancer cells and in the presence of the ligand heregulin (HRG) the ErbB-2/ErbB-3 receptors form a signaling heterodimer that can affect cell proliferation and apoptosis. The major goal of the present study was to determine whether endogenous HRG causes autocrine/paracrine activation of ErbB-2/ErbB-3 and contributes to the proliferation of mammary epithelial tumor cells. Tyrosine-phosphorylated (activated) ErbB-2 and ErbB-3 receptors were detected in the majority of extracts from tumors that had formed spontaneously or as a result of oncogene expression. HRG-1 transcripts and protein were found in the epithelial cells of most of these mouse mammary tumors. Various mouse mammary cell lines also contained activated ErbB-2/ErbB-3 and HRG transcripts. A approximately 50 kDa C-terminal fragment of pro-HRG was detected, which indicates that the HRG-1 precursor is readily processed by these cells. It is likely that the secreted mature HRG activated the ErbB-2/3 receptors. Addition of an antiserum against HRG to the mammary epithelial tumor cell line TM-6 reduced ErbB-3 Tyr-phosphorylation. Treatment with HRG-1 siRNA oligonucleotides or infection with a retroviral construct to stably express HRG siRNA effectively reduced HRG protein levels, ErbB-2/ErbB-3 activation, and the rate of proliferation, which could be reversed by the addition of HRG. The cumulative findings from these experiments show that coexpression of the HRG ligand contributes to activation of ErbB-2/Erb-3 in mouse mammary tumor cells in an autocrine or paracrine fashion. JF - Molecular carcinogenesis AU - Schmitt, M AU - Walker, M P AU - Richards, R G AU - Bocchinfuso, W P AU - Fukuda, T AU - Medina, D AU - Kittrell, F S AU - Korach, K S AU - DiAugustine, R P AD - Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 490 EP - 505 VL - 45 IS - 7 SN - 0899-1987, 0899-1987 KW - DNA Primers KW - 0 KW - Neuregulin-1 KW - Peptide Fragments KW - RNA, Small Interfering KW - Recombinant Proteins KW - Receptor, ErbB-2 KW - EC 2.7.10.1 KW - Index Medicus KW - Animals KW - Humans KW - RNA, Small Interfering -- genetics KW - Amino Acid Sequence KW - Cell Line, Tumor KW - Mice KW - Plasmids KW - Gene Expression Regulation, Neoplastic KW - Polymerase Chain Reaction KW - Peptide Fragments -- chemistry KW - Transfection KW - Recombinant Proteins -- metabolism KW - Immunohistochemistry KW - Female KW - Receptor, ErbB-2 -- genetics KW - Neuregulin-1 -- metabolism KW - Neuregulin-1 -- genetics KW - Receptor, ErbB-2 -- physiology KW - Mammary Neoplasms, Experimental -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68581239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+carcinogenesis&rft.atitle=Expression+of+heregulin+by+mouse+mammary+tumor+cells%3A+role+in+activation+of+ErbB+receptors.&rft.au=Schmitt%2C+M%3BWalker%2C+M+P%3BRichards%2C+R+G%3BBocchinfuso%2C+W+P%3BFukuda%2C+T%3BMedina%2C+D%3BKittrell%2C+F+S%3BKorach%2C+K+S%3BDiAugustine%2C+R+P&rft.aulast=Schmitt&rft.aufirst=M&rft.date=2006-07-01&rft.volume=45&rft.issue=7&rft.spage=490&rft.isbn=&rft.btitle=&rft.title=Molecular+carcinogenesis&rft.issn=08991987&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-08 N1 - Date created - 2006-06-27 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Drug interactions in cancer therapy. AN - 68579820; 16794637 AB - Drug interactions in oncology are of particular importance owing to the narrow therapeutic index and the inherent toxicity of anticancer agents. Interactions with other medications can cause small changes in the pharmacokinetics or pharmacodynamics of a chemotherapy agent that could significantly alter its efficacy or toxicity. Improvements in in vitro methods and early clinical testing have made the prediction of potentially clinically significant drug interactions possible. We outline the types of drug interaction that occur in oncology, the mechanisms that underlie these interactions and describe select examples. JF - Nature reviews. Cancer AU - Scripture, Charity D AU - Figg, William D AD - Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Building 10, Room 5A01, MSC1910, Bethesda, Maryland 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 546 EP - 558 VL - 6 IS - 7 SN - 1474-175X, 1474-175X KW - Antineoplastic Agents KW - 0 KW - Index Medicus KW - Animals KW - Humans KW - Neoplasms -- drug therapy KW - Drug Interactions KW - Antineoplastic Agents -- pharmacokinetics KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68579820?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Drug+interactions+in+cancer+therapy.&rft.au=Scripture%2C+Charity+D%3BFigg%2C+William+D&rft.aulast=Scripture&rft.aufirst=Charity&rft.date=2006-07-01&rft.volume=6&rft.issue=7&rft.spage=546&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Nat Rev Cancer. 2006 Sep;6(9):741 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Intrapatient dose escalation of anti-CTLA-4 antibody in patients with metastatic melanoma. AN - 68579611; 16799341 AB - We previously reported our experience in treating 56 patients with metastatic melanoma using a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) antibody. Durable tumor regressions were seen that correlated with the induction of autoimmune toxicities. In this study, we treated 46 additional patients using an intrapatient dose escalation schema to test whether higher doses of anti-CTLA-4 antibody would induce increased autoimmunity and concomitant tumor regression. Twenty-three patients started anti-CTLA-4 antibody administration at 3 mg/kg and 23 patients started treatment at 5 mg/kg, receiving doses every 3 weeks. Patients were dose-escalated every other dose to a maximum of 9 mg/kg or until objective clinical responses or grade III/IV autoimmune toxicity were seen. Escalating doses of antibody resulted in proportionally higher plasma concentrations. Sixteen patients (35%) experienced a grade III/IV autoimmune toxicity. Five patients (11%) achieved an objective clinical response. Two of the responses are ongoing at 13 and 16 months, respectively. Flow cytometric analysis of peripheral blood revealed significant increases in both T-cell surface markers of activation and memory phenotype. Thus, higher serum levels and prolonged administration of anti-CTLA-4 antibody resulted in a trend toward a greater incidence of grade III/IV autoimmune toxicity than previously reported, but did not seem to increase objective response rates. JF - Journal of immunotherapy (Hagerstown, Md. : 1997) AU - Maker, Ajay V AU - Yang, James C AU - Sherry, Richard M AU - Topalian, Suzanne L AU - Kammula, Udai S AU - Royal, Richard E AU - Hughes, Marybeth AU - Yellin, Michael J AU - Haworth, Leah R AU - Levy, Catherine AU - Allen, Tamika AU - Mavroukakis, Sharon A AU - Attia, Peter AU - Rosenberg, Steven A AD - Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA. PY - 2006 SP - 455 EP - 463 VL - 29 IS - 4 SN - 1524-9557, 1524-9557 KW - Antibodies, Monoclonal KW - 0 KW - Antibodies, Neoplasm KW - Antigens, CD KW - Antigens, Differentiation KW - Antigens, Neoplasm KW - CTLA-4 Antigen KW - CTLA4 protein, human KW - Index Medicus KW - Combined Modality Therapy KW - Humans KW - Dose-Response Relationship, Immunologic KW - Adult KW - Autoimmunity KW - Aged KW - Middle Aged KW - Male KW - Female KW - Melanoma -- secondary KW - Antigens, Differentiation -- immunology KW - Antibodies, Neoplasm -- immunology KW - Antibodies, Neoplasm -- administration & dosage KW - Melanoma -- therapy KW - Antibodies, Monoclonal -- administration & dosage KW - Antibodies, Monoclonal -- immunology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68579611?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.atitle=Intrapatient+dose+escalation+of+anti-CTLA-4+antibody+in+patients+with+metastatic+melanoma.&rft.au=Maker%2C+Ajay+V%3BYang%2C+James+C%3BSherry%2C+Richard+M%3BTopalian%2C+Suzanne+L%3BKammula%2C+Udai+S%3BRoyal%2C+Richard+E%3BHughes%2C+Marybeth%3BYellin%2C+Michael+J%3BHaworth%2C+Leah+R%3BLevy%2C+Catherine%3BAllen%2C+Tamika%3BMavroukakis%2C+Sharon+A%3BAttia%2C+Peter%3BRosenberg%2C+Steven+A&rft.aulast=Maker&rft.aufirst=Ajay&rft.date=2006-07-01&rft.volume=29&rft.issue=4&rft.spage=455&rft.isbn=&rft.btitle=&rft.title=Journal+of+immunotherapy+%28Hagerstown%2C+Md.+%3A+1997%29&rft.issn=15249557&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-28 N1 - Date created - 2006-06-26 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Cited By: Immunity. 1995 Nov;3(5):541-7 [7584144] J Exp Med. 1996 Jun 1;183(6):2541-50 [8676075] Annu Rev Immunol. 1996;14:233-58 [8717514] J Immunol. 1996 Aug 15;157(4):1333-6 [8759711] J Neuroimmunol. 1997 Mar;73(1-2):57-62 [9058759] Proc Natl Acad Sci U S A. 1997 Jul 22;94(15):8099-103 [9223321] Cancer Res. 1997 Sep 15;57(18):4036-41 [9307290] J Exp Med. 1998 Feb 2;187(3):427-32 [9449722] Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10067-71 [9707601] Diabetes. 1999 Mar;48(3):652-7 [10078573] Scand J Immunol. 1999 Mar;49(3):237-43 [10102640] J Immunol. 1999 May 15;162(10):5813-20 [10229815] J Exp Med. 1999 Aug 2;190(3):355-66 [10430624] J Immunol Methods. 2004 Oct;293(1-2):127-42 [15541283] Eur J Immunol. 2004 Dec;34(12):3485-96 [15484187] J Clin Oncol. 2005 Sep 1;23(25):6043-53 [16087944] Ann Surg Oncol. 2005 Dec;12(12):1005-16 [16283570] J Natl Cancer Inst. 2000 Feb 2;92(3):205-16 [10655437] Cancer Res. 2000 May 1;60(9):2444-8 [10811122] J Exp Med. 2000 Jul 17;192(2):295-302 [10899916] J Exp Med. 2000 Jul 17;192(2):303-10 [10899917] Genes Immun. 2000 Feb;1(3):170-84 [11196709] Annu Rev Immunol. 2001;19:565-94 [11244047] J Exp Med. 2001 Aug 20;194(4):481-9 [11514604] J Exp Med. 2001 Sep 17;194(6):823-32 [11560997] Nat Rev Immunol. 2001 Dec;1(3):220-8 [11905831] Curr Opin Immunol. 2002 Jun;14(3):391-6 [11973140] Nat Immunol. 2002 Jul;3(7):611-8 [12087419] Science. 2002 Oct 25;298(5594):850-4 [12242449] Nat Immunol. 2002 Nov;3(11):991-8 [12407406] Nat Immunol. 2003 Mar;4(3):217-24 [12605231] Annu Rev Immunol. 2003;21:305-34 [12471050] Annu Rev Immunol. 2003;21:807-39 [12615893] J Immunol. 2003 Mar 15;170(6):3401-7 [12626601] Cancer Cell. 2003 May;3(5):431-7 [12781360] Cancer Res. 2003 Jun 15;63(12):3281-8 [12810660] Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8372-7 [12826605] J Exp Med. 2003 Aug 18;198(4):569-80 [12925674] Nat Rev Cancer. 2003 Sep;3(9):666-75 [12951585] J Immunol. 2003 Dec 1;171(11):5673-7 [14634073] Curr Opin Mol Ther. 2004 Feb;6(1):71-7 [15011783] Science. 1970 Sep 11;169(3950):1042-9 [4194660] Science. 1990 Jun 15;248(4961):1349-56 [2113314] J Exp Med. 1991 Mar 1;173(3):759-62 [1847724] J Exp Med. 1991 Sep 1;174(3):561-9 [1714933] J Immunol. 1992 Jul 15;149(2):380-8 [1320641] J Immunol. 1993 Oct 1;151(7):3489-99 [8397258] Immunity. 1994 Aug;1(5):405-13 [7882171] Science. 1995 Nov 10;270(5238):985-8 [7481803] Science. 1996 Mar 22;271(5256):1734-6 [8596936] J Exp Med. 1996 Jun 1;183(6):2533-40 [8676074] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Role of exposure to environmental chemicals in the developmental basis of reproductive disease and dysfunction. AN - 68574078; 16804815 AB - There is a paradigm shift in science at present that indicates that the onset of many diseases, including reproductive diseases and dysfunctions, are already programmed in utero or in the early postnatal period. This new field is called the developmental basis of health and disease. Although focus has been on the role of in utero nutrition and its effects on subsequent adult-onset diseases, it is clear that exposure to environmental stressors/toxicants in utero or during early development can also increase susceptibility to disease later in life. The mechanism for this in utero and early developmental effect is thought to be altered epigenetic control of gene expression, which alters developmental programming and results in a tissue that may appear normal but is functionally compromised. Although this concept is still a hypothesis, this review addresses the current state of data relating to proving its importance and role in reproductive diseases. If the developmental basis of disease is shown to be true, then examination of the etiology of disease and prevention and intervention strategies will need to be modified to fit the new paradigm. JF - Seminars in reproductive medicine AU - Heindel, Jerrold J AD - Division of Extramural Research and Training, Cellular, Organs, National Institute of Environmental Health Sciences, Department of Health and Human Service, North Carolina 27709, USA. heindelj@niehs.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 168 EP - 177 VL - 24 IS - 3 SN - 1526-8004, 1526-8004 KW - Environmental Pollutants KW - 0 KW - Diethylstilbestrol KW - 731DCA35BT KW - Index Medicus KW - Prostate -- drug effects KW - Animals KW - Prostate -- growth & development KW - Diethylstilbestrol -- adverse effects KW - Humans KW - Prostate -- embryology KW - Environmental Exposure KW - Male KW - Female KW - Pregnancy KW - Reproduction -- physiology KW - Infertility -- chemically induced KW - Human Development -- drug effects KW - Environmental Pollutants -- adverse effects KW - Prenatal Exposure Delayed Effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68574078?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+reproductive+medicine&rft.atitle=Role+of+exposure+to+environmental+chemicals+in+the+developmental+basis+of+reproductive+disease+and+dysfunction.&rft.au=Heindel%2C+Jerrold+J&rft.aulast=Heindel&rft.aufirst=Jerrold&rft.date=2006-07-01&rft.volume=24&rft.issue=3&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Seminars+in+reproductive+medicine&rft.issn=15268004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-24 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Environmental influences on female fecundity and fertility. AN - 68572894; 16804813 AB - An increasing body of evidence suggests that environmental exposures are adversely influencing female fecundity and fertility. Endocrine-disrupting compounds (EDCs) are of particular concern, due to their ability to interfere with the body's hormonal milieu. An overview of the literature regarding the effect of EDCs on female fecundity and fertility end points such as puberty, menstruation, endometriosis, time to pregnancy, pregnancy loss, reproductive senescence, and secondary sex ratio is presented. Methodologic challenges in studying the effects EDCs on sensitive reproductive end points are discussed and include exposure to mixtures, the choice of biologic media in which to measure compounds, laboratory methods, and varying modeling techniques. Also reviewed are novel technologies for home-based biospecimen collection and testing that offer promise for field-based research aimed at addressing questions about environmental influences on female fecundity and fertility. JF - Seminars in reproductive medicine AU - Buck Louis, Germaine M AU - Lynch, Courtney D AU - Cooney, Maureen A AD - Epidemiology Branch, Division of Epidemiology, Statistics & Prevention Research, National Institute of Child Health & Human Development, Rockville, Maryland 20852, USA. louisg@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 147 EP - 155 VL - 24 IS - 3 SN - 1526-8004, 1526-8004 KW - Endocrine Disruptors KW - 0 KW - Environmental Pollutants KW - Index Medicus KW - Pregnancy Tests -- methods KW - Puberty -- physiology KW - Humans KW - Environmental Exposure KW - Ovulation Detection KW - Menstruation KW - Female KW - Pregnancy KW - Environment KW - Endocrine Disruptors -- adverse effects KW - Fertility -- physiology KW - Environmental Pollutants -- adverse effects KW - Fertility -- drug effects UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68572894?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Seminars+in+reproductive+medicine&rft.atitle=Environmental+influences+on+female+fecundity+and+fertility.&rft.au=Buck+Louis%2C+Germaine+M%3BLynch%2C+Courtney+D%3BCooney%2C+Maureen+A&rft.aulast=Buck+Louis&rft.aufirst=Germaine&rft.date=2006-07-01&rft.volume=24&rft.issue=3&rft.spage=147&rft.isbn=&rft.btitle=&rft.title=Seminars+in+reproductive+medicine&rft.issn=15268004&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-24 N1 - Date created - 2006-06-28 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Immunotoxin therapy of cancer. AN - 68570222; 16794638 AB - Rationally designed anticancer agents that target cell-surface antigens or receptors represent a promising approach for treating cancer patients. However, antibodies that bind these targets are often, by themselves, non-cytotoxic. By attaching potent toxins we can dramatically improve the clinical utility of some anti-tumour antibodies. Here we describe the construction and clinical utility of several recombinant immunotoxins; each of which is composed of antibody Fv fragments fused to powerful bacterial toxins. Results from clinical trials indicate that recombinant immunotoxins and similar agents that are designed to combine antibody selectivity with toxin cell-killing potency will be useful additions to cancer therapy. JF - Nature reviews. Cancer AU - Pastan, Ira AU - Hassan, Raffit AU - Fitzgerald, David J AU - Kreitman, Robert J AD - Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institues of Health, 37 Convent Drive, Bethesda, MD 20892-4264, USA. pastani@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 559 EP - 565 VL - 6 IS - 7 SN - 1474-175X, 1474-175X KW - Antineoplastic Agents KW - 0 KW - Bacterial Toxins KW - Immunoglobulin Variable Region KW - Immunotoxins KW - Recombinant Proteins KW - Index Medicus KW - Animals KW - Humans KW - Immunoglobulin Variable Region -- immunology KW - Bacterial Toxins -- therapeutic use KW - Recombinant Proteins -- immunology KW - Bacterial Toxins -- immunology KW - Immunoglobulin Variable Region -- therapeutic use KW - Recombinant Proteins -- therapeutic use KW - Immunotherapy KW - Immunotoxins -- therapeutic use KW - Neoplasms -- therapy KW - Antineoplastic Agents -- therapeutic use UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68570222?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+reviews.+Cancer&rft.atitle=Immunotoxin+therapy+of+cancer.&rft.au=Pastan%2C+Ira%3BHassan%2C+Raffit%3BFitzgerald%2C+David+J%3BKreitman%2C+Robert+J&rft.aulast=Pastan&rft.aufirst=Ira&rft.date=2006-07-01&rft.volume=6&rft.issue=7&rft.spage=559&rft.isbn=&rft.btitle=&rft.title=Nature+reviews.+Cancer&rft.issn=1474175X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-18 N1 - Date created - 2006-06-23 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - NTP Technical Report on the comparative toxicity studies of allyl acetate (CAS No. 591-87-7), allyl alcohol (CAS No. 107-18-6) and acrolein (CAS No. 107-02-8) administered by gavage to F344/N rats and B6C3F1 mice. AN - 68237151; 17160105 AB - Allyl acetate, allyl alcohol, and acrolein are used in the manufacture of detergents, plastics, pharmaceuticals, and chemicals and as agricultural agents and food additives. Male and female F344/N rats and B6C3F(1) mice received allyl acetate, allyl alcohol, or acrolein by gavage for 14 weeks. Genetic toxicology studies were conducted in Salmonella typhimurium, Drosophila melanogaster, cultured Chinese hamster ovary cells, rat bone marrow erythrocytes, and mouse peripheral blood erythrocytes. Groups of 10 male and 10 female rats were administered 0, 6, 12, 25, 50, or 100 mg allyl acetate/kg body weight, 0, 1.5, 3, 6, 12, or 25 mg/kg allyl alcohol, or 0, 0.75, 1.25, 2.5, 5, or 10 mg/kg acrolein in 0.5% methylcellulose by gavage, 5 days per week for 14 weeks. Groups of 10 male and 10 female mice were administered 0, 8, 16, 32, 62.5, or 125 mg/kg allyl acetate, 0, 3, 6, 12, 25, or 50 mg/kg allyl alcohol, or 0, 1.25, 2.5, 5, 10, or 20 mg/kg acrolein in 0.5% methylcellulose by gavage, 5 days per week for 14 weeks. In the allyl acetate rat study, all males and females in the 100 mg/kg groups died or were killed moribund by day 8; there were no other deaths. In the allyl alcohol study, all rats survived to the end of the study except one 6 mg/kg female. In the acrolein rat study, eight males and eight females in the 10 mg/kg groups died by week 9 of the study. Two males in the 2.5 and 5 mg/kg groups and one or two females in the 1.25, 2.5, and 5 mg/kg groups also died early; two of these deaths were gavage accidents. In the allyl acetate mouse study, all males and females in the 125 mg/kg group died during the first week of the study. All other early deaths, except five 62.5 mg/kg males and one 32 mg/kg female, were gavage accidents. In the allyl alcohol mouse study, one 50 mg/kg female died due to a gavage accident; all other animals survived to the end of the study. In the acrolein mouse study, all males and females administered 20 mg/kg died during the first week of the study. All other early deaths, except one male and one female administered 10 mg/kg, were unrelated to chemical administration. The concentration of 3-hydroxypropyl mercapturic acid (3-HPM) in the urine of rats and mice was determined after the first dose of chemical and at the end of the 14-week study. At both time points, the concentrations of 3-HPM in the urine of animals that received allyl acetate or allyl alcohol increased linearly with dose. In animals dosed with acrolein, the concentrations of 3-HPM exhibited a nonlinear increase with dose at the first time point. At the end of the study, the concentration of 3-HPM in the urine of animals dosed with acrolein was linear with dose except at the highest concentration administered. Since urine volumes were not recorded during the urine collection, complete quantitation of these data was not possible. The final mean body weights and mean body weight gains of male rats administered 12 or 50 mg/kg allyl acetate and of male and female rats administered 10 mg/kg acrolein were significantly less than those of the vehicle controls. The mean body weight gain of male mice in the 50 mg/kg group in the allyl alcohol study was also less than that of the vehicle controls. Final mean body weights and mean body weight gains of dosed female rats and male and female mice in the allyl acetate studies, male and female rats and female mice in the allyl alcohol studies, and male and female mice in the acrolein studies were generally similar to those of the respective vehicle controls. Clinical findings related to allyl acetate administration included pallor, eye or nasal discharge, ruffled fur, lethargy, diarrhea, and thinness among rats in the 100 mg/kg groups and lethargy, abnormal breathing, thinness, and ruffled fur among mice that died early. In the acrolein study, clinical findings included abnormal breathing, eye or nasal discharge, ruffled fur, thinness, and lethargy in rats in the 10 mg/kg groups. The liver weights of male rats administered 25 mg/kg allyl alcohol, female rats administered 50 mg/kg allyl acetate or 5 or 10 mg/kg acrolein, and male mice administered 10 mg/kg acrolein were significantly greater than those of the vehicle controls. Female rats administered 10 mg/kg acrolein had significantly lower absolute and relative thymus weights than did the vehicle controls. Female rats administered 25 mg/kg allyl alcohol spent more time in diestrus and less time in metestrus than the vehicle controls. The estrous cycles of female mice dosed with 16 or 32 mg/kg allyl acetate were significantly longer than that of the vehicle controls. Gross lesions related to allyl acetate treatment were observed in the liver, forestomach, and thorax/abdomen of male and female rats in the 100 mg/kg groups. Microscopically, the incidences of forestomach squamous epithelial hyperplasia were significantly increased in male rats administered 12 mg/kg or greater, female rats administered 25 or 50 mg/kg, male mice administered 32 or 62.5 mg/kg, and female mice administered 16, 32, or 62.5 mg/kg. Forestomach necrosis, hemorrhage, and inflammation were present in most rats in the 100 mg/kg groups, and the incidence of hemorrhage in 125 mg/kg male mice was increased; male mice in the 62.5 and 125 mg/kg groups and 125 mg/kg female mice had significantly increased incidences of glandular stomach hemorrhage. Increased incidences of several liver lesions occurred in male or female rats administered 50 or 100 mg/kg, and to a lesser extent in 25 mg/kg rats, 62.5 mg/kg male mice, and 125 mg/kg male and female mice. Bone marrow hyperplasia, hemorrhage or depletion in the mediastinal, mandibular, and mesenteric lymph nodes, hemorrhage and necrosis of the thymus, and hematopoietic cell proliferation of the red pulp were also observed in 100 mg/kg rats. Increased incidences of necrosis in the mandibular and mesenteric lymph nodes, spleen, and thymus were observed in 62.5 and 125 mg/kg mice. Male and female rats administered 6 mg/kg allyl alcohol or greater and male and female mice administered 12 mg/kg allyl alcohol or greater had significantly increased incidences of squamous hyperplasia of the forestomach epithelium. Female rats in the 25 mg/kg group had significantly increased incidences of bile duct hyperplasia and periportal hepatocyte hypertrophy in the liver. Incidences of portal cytoplasmic vacuolization were significantly increased in 50 mg/kg male mice and female mice in the 25 and 50 mg/kg groups. Gross lesions related to acrolein treatment were observed in the forestomach and glandular stomach of male and female rats in the 10 mg/kg groups and 20 mg/kg female mice. Microscopically, the incidences of squamous hyperplasia of the forestomach epithelium were significantly increased in male rats in the 5 and 10 mg/kg groups, female rats administered 2.5 mg/kg or greater, and male and female mice administered 2.5, 5, or 10 mg/kg. Male and female rats in the 10 mg/kg groups and 20 mg/kg male and female mice had significantly increased incidences of glandular stomach hemorrhage. Female mice in the 20 mg/kg group also had significantly increased incidences of glandular stomach inflammation and epithelial necrosis. Allyl acetate was mutagenic in S. typhimurium strains TA100 and TA1535, in the absence of S9 activation. With S9, no mutagenicity was detected in these two strains; negative results were obtained in strains TA97 and TA98, with and without S9. Allyl alcohol was not mutagenic in four strains of S. typhimurium, with or without S9 metabolic activation. Acrolein, tested in a preincubation protocol, was weakly mutagenic in S. typhimurium strain TA100 in the presence of 10% induced rat liver S9. Equivocal results were obtained in strains TA100 and TA1535 with 10% induced hamster liver S9. Negative results were obtained with TA97, TA98, and TA1538 under all test conditions, and acrolein gave negative results in all four S. typhimurium strains tested for mutation induction under a vapor protocol. No induction of micronuclei was noted in bone marrow erythrocytes of male rats administered allyl acetate by gavage three times at 24-hour intervals. No significant increases in micronucleated erythrocytes were noted in bone marrow samples from male rats administered allyl alcohol by intraperitoneal injection for 3 days. A small, but significant increase in the frequency of micronucleated normochromatic erythrocytes was observed in the peripheral blood of female mice administered allyl acetate by gavage for 14 weeks; no increase was observed in male mice. No increases in the frequencies of micronucleated normochromatic erythrocytes were observed in the peripheral blood of male or female mice administered allyl alcohol or acrolein by gavage for 14 weeks. Acrolein induced sister chromatid exchanges in cultured Chinese hamster ovary cells in the absence, but not the presence, of S9; it did not induce chromosomal aberrations, with or without S9. Results of three independent Drosophila melanogaster sex linked recessive lethal tests in which acrolein was administered to adult flies via feeding or injection and to larvae via feeding were negative. JF - Toxicity report series AU - Irwin, Rick D AD - National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1 EP - 73, A1-H10 IS - 48 SN - 1521-4621, 1521-4621 KW - Acetates KW - 0 KW - Allyl Compounds KW - Mutagens KW - Propanols KW - allyl alcohol KW - 3W678R12M0 KW - Acrolein KW - 7864XYD3JJ KW - allyl acetate KW - E4U5E5990I KW - Index Medicus KW - Animals KW - Hyperplasia -- pathology KW - Dose-Response Relationship, Drug KW - Intubation, Gastrointestinal KW - Mutagens -- toxicity KW - Salmonella typhimurium -- drug effects KW - Mice KW - Estrus -- drug effects KW - Rats KW - Mice, Inbred Strains KW - Rats, Inbred F344 KW - Hyperplasia -- chemically induced KW - Micronucleus Tests KW - Liver -- drug effects KW - Gastrointestinal Tract -- pathology KW - Gastrointestinal Tract -- drug effects KW - Sister Chromatid Exchange -- drug effects KW - Body Weight -- drug effects KW - Toxicity Tests, Acute KW - CHO Cells KW - Male KW - Female KW - Organ Size -- drug effects KW - Cricetinae KW - Acetates -- administration & dosage KW - Propanols -- toxicity KW - Propanols -- administration & dosage KW - Allyl Compounds -- administration & dosage KW - Allyl Compounds -- toxicity KW - Acetates -- toxicity KW - Acrolein -- toxicity KW - Acrolein -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68237151?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicity+report+series&rft.atitle=NTP+Technical+Report+on+the+comparative+toxicity+studies+of+allyl+acetate+%28CAS+No.+591-87-7%29%2C+allyl+alcohol+%28CAS+No.+107-18-6%29+and+acrolein+%28CAS+No.+107-02-8%29+administered+by+gavage+to+F344%2FN+rats+and+B6C3F1+mice.&rft.au=Irwin%2C+Rick+D&rft.aulast=Irwin&rft.aufirst=Rick&rft.date=2006-07-01&rft.volume=&rft.issue=48&rft.spage=1&rft.isbn=&rft.btitle=&rft.title=Toxicity+report+series&rft.issn=15214621&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-01-03 N1 - Date created - 2006-12-12 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling. AN - 68181535; 17016747 AB - Ongoing efforts to model P2Y receptors for extracellular nucleotides, i.e., endogenous ADP, ATP, UDP, UTP, and UDP-glucose, were summarized and correlated for the eight known subtypes. The rhodopsin-based homology modeling of the P2Y receptors is supported by a growing body of site-directed mutagenesis data, mainly for P2Y(1) receptors. By comparing molecular models of the P2Y receptors, it was concluded that nucleotide binding could occur in the upper part of the helical bundle, with the ribose moiety accommodated between transmembrane domain (TM) 3 and TM7. The nucleobase was oriented towards TM1, TM2, and TM7, in the direction of the extracellular side of the receptor. The phosphate chain was oriented towards TM6, in the direction of the extracellular loops (ELs), and was coordinated by three critical cationic residues. In particular, in the P2Y(1), P2Y(2), P2Y(4), and P2Y(6) receptors the nucleotide ligands had very similar positions. ADP in the P2Y(12) receptor was located deeper inside the receptor in comparison to other subtypes, and the uridine moiety of UDP-glucose in the P2Y(14) receptor was located even deeper and shifted toward TM7. In general, these findings are in agreement with the proposed binding site of small molecules to other class A GPCRs. JF - Journal of computer-aided molecular design AU - Ivanov, Andrei A AU - Costanzi, Stefano AU - Jacobson, Kenneth A AD - Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. PY - 2006 SP - 417 EP - 426 VL - 20 IS - 7-8 SN - 0920-654X, 0920-654X KW - Amino Acids KW - 0 KW - Ligands KW - Nucleotides KW - Receptors, Purinergic P2 KW - Rhodopsin KW - 9009-81-8 KW - Index Medicus KW - Humans KW - Molecular Sequence Data KW - Amino Acid Sequence KW - Structure-Activity Relationship KW - Binding Sites KW - Structural Homology, Protein KW - Nucleotides -- metabolism KW - Models, Molecular KW - Receptors, Purinergic P2 -- metabolism KW - Receptors, Purinergic P2 -- chemistry KW - Rhodopsin -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68181535?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+computer-aided+molecular+design&rft.atitle=Defining+the+nucleotide+binding+sites+of+P2Y+receptors+using+rhodopsin-based+homology+modeling.&rft.au=Ivanov%2C+Andrei+A%3BCostanzi%2C+Stefano%3BJacobson%2C+Kenneth+A&rft.aulast=Ivanov&rft.aufirst=Andrei&rft.date=2006-07-01&rft.volume=20&rft.issue=7-8&rft.spage=417&rft.isbn=&rft.btitle=&rft.title=Journal+of+computer-aided+molecular+design&rft.issn=0920654X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2007-03-20 N1 - Date created - 2006-11-24 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - CPS1, a homolog of the Streptococcus pneumoniae type 3 polysaccharide synthase gene, is important for the pathobiology of Cryptococcus neoformans. AN - 68105288; 16790766 AB - The polysaccharide capsule is known to be the major factor required for the virulence of Cryptococcus neoformans. We have cloned and characterized a gene, designated CPS1, that encodes a protein containing a glycosyltransferase moiety and shares similarity with the type 3 polysaccharide synthase encoded by the cap3B gene of Streptococcus pneumoniae. Cps1p also shares similarity with hyaluronan synthase of higher eukaryotes. Deletion of the CPS1 gene from a serotype D strain of C. neoformans resulted in a slight reduction of the capsule size as observed by using an India ink preparation. The growth at 37 degrees C was impaired, and the ability to associate with human brain endothelial cells in vitro was also significantly reduced by the deletion of CPS1. Using site-specific mutagenesis, we showed that the conserved glycosyltransferase domains are critical for the ability of the strain to grow at elevated temperatures. A hyaluronan enzyme-linked immunosorbent assay method demonstrated that CPS1 is important for the synthesis of hyaluronan or its related polysaccharides in C. neoformans. Comparisons between the wild-type and the cps1Delta strains, using three different transmission electron microscopic methods, indicated that the CPS1 gene product is involved in the composition or maintenance of an electron-dense layer between the outer cell wall and the capsule. These and the virulence studies in a mouse model suggested that the CPS1 gene is important in the pathobiology of C. neoformans. JF - Infection and immunity AU - Chang, Y C AU - Jong, A AU - Huang, S AU - Zerfas, P AU - Kwon-Chung, K J AD - National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 3930 EP - 3938 VL - 74 IS - 7 SN - 0019-9567, 0019-9567 KW - Fungal Proteins KW - 0 KW - Cap3B protein, Streptococcus pneumoniae KW - EC 2.4.- KW - Glycosyltransferases KW - CPS1 protein, Cryptococcus neoformans KW - EC 2.4.1.- KW - type 3 capsular polysaccharide synthase KW - Index Medicus KW - Microcirculation -- enzymology KW - Animals KW - Sepsis -- pathology KW - Endothelium, Vascular -- enzymology KW - Brain -- blood supply KW - Humans KW - Brain -- microbiology KW - Disease Models, Animal KW - Mice KW - Endothelium, Vascular -- microbiology KW - Mice, Inbred BALB C KW - Virulence KW - Brain -- enzymology KW - Microcirculation -- microbiology KW - Cells, Cultured KW - Molecular Sequence Data KW - Sepsis -- microbiology KW - Female KW - Fungal Proteins -- chemistry KW - Cryptococcus neoformans -- enzymology KW - Fungal Proteins -- physiology KW - Streptococcus pneumoniae -- enzymology KW - Glycosyltransferases -- physiology KW - Bacterial Capsules -- chemistry KW - Glycosyltransferases -- genetics KW - Cryptococcus neoformans -- ultrastructure KW - Cryptococcus neoformans -- genetics KW - Fungal Proteins -- genetics KW - Cryptococcus neoformans -- pathogenicity KW - Bacterial Capsules -- physiology KW - Glycosyltransferases -- chemistry KW - Streptococcus pneumoniae -- genetics UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68105288?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+immunity&rft.atitle=CPS1%2C+a+homolog+of+the+Streptococcus+pneumoniae+type+3+polysaccharide+synthase+gene%2C+is+important+for+the+pathobiology+of+Cryptococcus+neoformans.&rft.au=Chang%2C+Y+C%3BJong%2C+A%3BHuang%2C+S%3BZerfas%2C+P%3BKwon-Chung%2C+K+J&rft.aulast=Chang&rft.aufirst=Y&rft.date=2006-07-01&rft.volume=74&rft.issue=7&rft.spage=3930&rft.isbn=&rft.btitle=&rft.title=Infection+and+immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-24 N1 - Date created - 2006-06-22 N1 - Date revised - 2017-01-13 N1 - Genetic sequence - AY063511; GENBANK N1 - SuppNotes - Cited By: J Biol Chem. 2000 Jan 7;275(1):497-506 [10617644] Virology. 2005 Nov 10;342(1):102-10 [16112160] J Exp Med. 2000 Mar 6;191(5):871-82 [10704467] Curr Opin Cell Biol. 2000 Oct;12(5):581-6 [10978893] Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3258-63 [11248066] Mol Microbiol. 2001 May;40(3):610-20 [11359567] Infect Immun. 2001 Jul;69(7):4536-44 [11401997] Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12003-8 [11593010] Nature. 2001 Dec 6;414(6864):648-52 [11740562] Mol Microbiol. 2002 Aug;45(3):837-49 [12139628] Eukaryot Cell. 2003 Aug;2(4):655-63 [12912884] J Med Microbiol. 2003 Nov;52(Pt 11):961-70 [14532340] J Biol Chem. 2003 Nov 28;278(48):47724-30 [14504286] Mol Microbiol. 2004 Apr;52(1):13-24 [15049807] Infect Immun. 2004 Sep;72(9):4985-95 [15321990] J Bacteriol. 1982 Jun;150(3):1414-21 [6804444] Infect Immun. 1989 Jul;57(7):1922-7 [2525113] Curr Opin Cell Biol. 1990 Oct;2(5):839-44 [1707285] FASEB J. 1992 Apr;6(7):2397-404 [1563592] J Bacteriol. 1993 Mar;175(5):1405-11 [8444802] J Exp Med. 1995 Mar 1;181(3):973-83 [7869055] Infect Immun. 1996 Jun;64(6):1977-83 [8675296] J Biol Chem. 1996 Nov 8;271(45):28581-92 [8910488] J Neuroimmunol. 1997 Jun;76(1-2):81-90 [9184636] Biochem J. 1997 Sep 15;326 ( Pt 3):929-39 [9334165] Infect Immun. 1998 May;66(5):2230-6 [9573112] Antimicrob Agents Chemother. 1999 Aug;43(8):1856-61 [10428902] J Bacteriol. 1999 Sep;181(18):5636-43 [10482503] Eukaryot Cell. 2004 Dec;3(6):1513-24 [15590825] Science. 2005 Feb 25;307(5713):1321-4 [15653466] J Biol Chem. 2000 Feb 11;275(6):3907-14 [10660543] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The novel dopamine D3 receptor antagonist NGB 2904 inhibits cocaine's rewarding effects and cocaine-induced reinstatement of drug-seeking behavior in rats. AN - 68087741; 16205781 AB - Accumulating evidence indicates that dopamine (DA) D(3) receptor antagonists appear highly promising in attenuating cocaine reward and relapse in preclinical models of addiction. In the present study, we investigated the effects of the novel D(3)-selective antagonist NGB 2904 (N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-3-fluorenylcarboxamide) on cocaine self-administration, cocaine-enhanced brain stimulation reward (BSR), and cocaine-triggered reinstatement of drug-seeking behavior in male Long-Evans rats. We found that: (1) acute intraperitoneal (i.p.) administration of NGB 2904 (0.1-10 mg/kg) failed to alter cocaine self-administration (0.5 mg/kg/infusion) under fixed-ratio 2 (FR2) reinforcement, but 1 or 5 mg/kg NGB 2904 significantly lowered the break-point for cocaine self-administration under progressive-ratio (PR) reinforcement; (2) cocaine (1, 2, and 10 mg/kg) significantly enhanced electrical BSR (decreased brain reward thresholds), while NGB 2904 significantly inhibited the enhancement of BSR elicited by 2 mg/kg, but not 10 mg/kg of cocaine; (3) NGB 2904 alone neither maintained self-administration behavior nor altered brain reward thresholds; and (4) NGB 2904 significantly inhibited cocaine-triggered reinstatement of extinguished drug-seeking behavior, but not sucrose-plus-sucrose-cue-triggered reinstatement of sucrose-seeking behavior. Overall, these data show that the novel D(3)-selective antagonist NGB 2904 attenuates cocaine's rewarding effects as assessed by PR self-administration, BSR, and cocaine-triggered reinstatement of cocaine-seeking behavior. Owing to these properties and to its lack of rewarding effects (as assessed by BSR and by substitution during drug self-administration), NGB 2904 merits further investigation as a potential agent for treatment of cocaine addiction. JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology AU - Xi, Zheng-Xiong AU - Newman, Amy Hauck AU - Gilbert, Jeremy G AU - Pak, Arlene C AU - Peng, Xiao-Qing AU - Ashby, Charles R AU - Gitajn, Leah AU - Gardner, Eliot L AD - Neuropsychopharmacology Section, Behavioral Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA. zxi@intra.nida.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1393 EP - 1405 VL - 31 IS - 7 SN - 0893-133X, 0893-133X KW - Dopamine Antagonists KW - 0 KW - Dopamine Uptake Inhibitors KW - Fluorenes KW - NGB 2904 KW - Piperazines KW - Cocaine KW - I5Y540LHVR KW - Index Medicus KW - Conditioning, Operant -- drug effects KW - Animals KW - Electric Stimulation -- methods KW - Drug Interactions KW - Reinforcement Schedule KW - Rats, Long-Evans KW - Conditioning, Operant -- physiology KW - Dose-Response Relationship, Drug KW - Brain -- radiation effects KW - Dopamine Uptake Inhibitors -- adverse effects KW - Cocaine -- administration & dosage KW - Cocaine -- adverse effects KW - Rats KW - Brain -- physiopathology KW - Behavior, Animal -- drug effects KW - Self Administration KW - Dopamine Uptake Inhibitors -- administration & dosage KW - Extinction, Psychological -- drug effects KW - Male KW - Reward KW - Cocaine-Related Disorders -- psychology KW - Cocaine-Related Disorders -- drug therapy KW - Behavior, Addictive -- drug therapy KW - Fluorenes -- administration & dosage KW - Piperazines -- administration & dosage KW - Dopamine Antagonists -- administration & dosage UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68087741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.atitle=The+novel+dopamine+D3+receptor+antagonist+NGB+2904+inhibits+cocaine%27s+rewarding+effects+and+cocaine-induced+reinstatement+of+drug-seeking+behavior+in+rats.&rft.au=Xi%2C+Zheng-Xiong%3BNewman%2C+Amy+Hauck%3BGilbert%2C+Jeremy+G%3BPak%2C+Arlene+C%3BPeng%2C+Xiao-Qing%3BAshby%2C+Charles+R%3BGitajn%2C+Leah%3BGardner%2C+Eliot+L&rft.aulast=Xi&rft.aufirst=Zheng-Xiong&rft.date=2006-07-01&rft.volume=31&rft.issue=7&rft.spage=1393&rft.isbn=&rft.btitle=&rft.title=Neuropsychopharmacology+%3A+official+publication+of+the+American+College+of+Neuropsychopharmacology&rft.issn=0893133X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-09-05 N1 - Date created - 2006-06-16 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - The mouse S100A15 ortholog parallels genomic organization, structure, gene expression, and protein-processing pattern of the human S100A7/A15 subfamily during epidermal maturation. AN - 68084762; 16528363 AB - The calcium-binding proteins of the human S100A7/A15 (hS100A7/A15) subfamily are differentially expressed in normal and pathological epidermis. The hS100A7 (psoriasin) and S100A15 reside in a chromosomal cluster of highly similar paralogs. To exploit the power of mouse models for determining functions of gene products, the corresponding S100A7/A15 ortholog was cloned and examined in murine skin. The single mouse S100A15 (mS100A15) gene encodes a protein of 104 amino acids with a predicted molecular weight of 12,870 Da and two EF-hand calcium binding sites. Using gene-specific primers and specific antibodies, expression of mS100A15 in both skin and isolated keratinocytes is confined to differentiating granular and cornified epidermal cells. Immunoblotting of epidermal extracts revealed a series of high molecular weight bands that are also recognized by an antibody for transglutaminase-mediated protein crosslinks. mS100A15 expression is upregulated in cultured keratinocytes induced to differentiate by calcium or phorbol esters. Maximal induction occurs concordantly with expression of late differentiation markers. Induction is enhanced in keratinocytes overexpressing protein kinase Calpha and is dependent on activator protein-1 transcription factors. The regulation, expression pattern and crosslinking of mS100A15 are consistent with the characteristics of the human orthologs, providing a valid surrogate model to study changes in these proteins associated with cutaneous pathologies. JF - The Journal of investigative dermatology AU - Wolf, Ronald AU - Voscopoulos, Christopher J AU - FitzGerald, Peter C AU - Goldsmith, Paul AU - Cataisson, Christophe AU - Gunsior, Michele AU - Walz, Markus AU - Ruzicka, Thomas AU - Yuspa, Stuart H AD - Laboratory of Cellular Carcinogenesis and Tumor Promotion, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-4255, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 1600 EP - 1608 VL - 126 IS - 7 SN - 0022-202X, 0022-202X KW - Amino Acids KW - 0 KW - Calcium-Binding Proteins KW - Phorbol Esters KW - S100 Proteins KW - S100A15 protein, mouse KW - S100A7 protein, human KW - S100A7A protein, human KW - Protein Kinase C-alpha KW - EC 2.7.11.13 KW - Calcium KW - SY7Q814VUP KW - Index Medicus KW - Animals KW - Keratinocytes -- chemistry KW - Humans KW - Amino Acids -- analysis KW - Calcium -- pharmacology KW - Mice KW - Skin Neoplasms -- genetics KW - Keratinocytes -- physiology KW - Mice, Inbred Strains KW - Phorbol Esters -- pharmacology KW - Cell Differentiation -- physiology KW - Cells, Cultured KW - Protein Kinase C-alpha -- physiology KW - Skin Diseases -- physiopathology KW - Cell Differentiation -- drug effects KW - Epidermis -- physiology KW - Models, Animal KW - Epidermis -- cytology KW - Protein Processing, Post-Translational KW - S100 Proteins -- analysis KW - Chromosome Mapping KW - Calcium-Binding Proteins -- analysis KW - Epidermis -- growth & development KW - S100 Proteins -- physiology KW - Calcium-Binding Proteins -- physiology KW - S100 Proteins -- genetics KW - Gene Expression Regulation KW - Calcium-Binding Proteins -- genetics KW - S100 Proteins -- chemistry KW - Calcium-Binding Proteins -- chemistry KW - Epidermis -- chemistry UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68084762?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=The+Journal+of+investigative+dermatology&rft.atitle=The+mouse+S100A15+ortholog+parallels+genomic+organization%2C+structure%2C+gene+expression%2C+and+protein-processing+pattern+of+the+human+S100A7%2FA15+subfamily+during+epidermal+maturation.&rft.au=Wolf%2C+Ronald%3BVoscopoulos%2C+Christopher+J%3BFitzGerald%2C+Peter+C%3BGoldsmith%2C+Paul%3BCataisson%2C+Christophe%3BGunsior%2C+Michele%3BWalz%2C+Markus%3BRuzicka%2C+Thomas%3BYuspa%2C+Stuart+H&rft.aulast=Wolf&rft.aufirst=Ronald&rft.date=2006-07-01&rft.volume=126&rft.issue=7&rft.spage=1600&rft.isbn=&rft.btitle=&rft.title=The+Journal+of+investigative+dermatology&rft.issn=0022202X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-01 N1 - Date created - 2006-06-16 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Comment In: J Invest Dermatol. 2006 Jul;126(7):1442-4 [16778811] N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Ethanol potentiates GABAergic synaptic transmission in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala. AN - 68077277; 16624993 AB - Interactions between ethanol and synaptic transmission mediated by gamma -amino-N-butyric acid (GABA) have been suggested to contribute to alcohol intoxication. Ethanol effects on postsynaptic GABAA receptors have been the major focus of this line of research. There is increasing evidence that ethanol potentiation of GABAergic transmission involves increased GABA release from presynaptic terminals. In the present study, a mechanically isolated neuron/bouton preparation from the basolateral amygdala was used to examine the effects of ethanol on spontaneous GABAergic synaptic currents elicited by GABA release from the presynaptic terminals. We found that ethanol application produced a rapid increase in the frequency of spontaneous GABAergic synaptic currents. An acute tolerance to ethanol was also observed, and this tolerance involved GABAB receptor activation. The ethanol-induced potentiation did not involve alterations in the function of postsynaptic GABAA receptors and was independent of presynaptic action potential firing. These findings indicate that ethanol potentiates GABA release, most likely via a direct action on presynaptic boutons. JF - Journal of neurophysiology AU - Zhu, Ping Jun AU - Lovinger, David M AD - Laboratory for Integrative Neuroscience, National Institute on Alcohol Abuse and Alcoholism, National Institute Health, Bethesda, MD 20892-9411, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 433 EP - 441 VL - 96 IS - 1 SN - 0022-3077, 0022-3077 KW - Central Nervous System Depressants KW - 0 KW - Receptors, GABA-A KW - Receptors, GABA-B KW - Ethanol KW - 3K9958V90M KW - gamma-Aminobutyric Acid KW - 56-12-2 KW - Index Medicus KW - Action Potentials -- physiology KW - Animals KW - Receptors, GABA-B -- physiology KW - Receptors, GABA-A -- physiology KW - Receptors, GABA-B -- drug effects KW - Receptors, GABA-B -- analysis KW - Electrophysiology KW - Receptors, GABA-A -- analysis KW - Rats KW - Rats, Sprague-Dawley KW - Alcoholic Intoxication -- physiopathology KW - In Vitro Techniques KW - Receptors, GABA-A -- drug effects KW - Excitatory Postsynaptic Potentials -- physiology KW - Central Nervous System Depressants -- pharmacology KW - Presynaptic Terminals -- chemistry KW - Neurons -- chemistry KW - Ethanol -- pharmacology KW - Synaptic Transmission -- drug effects KW - Neurons -- physiology KW - gamma-Aminobutyric Acid -- physiology KW - Amygdala -- physiology KW - gamma-Aminobutyric Acid -- metabolism KW - Synaptic Transmission -- physiology KW - Presynaptic Terminals -- physiology KW - Presynaptic Terminals -- metabolism UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68077277?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+neurophysiology&rft.atitle=Ethanol+potentiates+GABAergic+synaptic+transmission+in+a+postsynaptic+neuron%2Fsynaptic+bouton+preparation+from+basolateral+amygdala.&rft.au=Zhu%2C+Ping+Jun%3BLovinger%2C+David+M&rft.aulast=Zhu&rft.aufirst=Ping&rft.date=2006-07-01&rft.volume=96&rft.issue=1&rft.spage=433&rft.isbn=&rft.btitle=&rft.title=Journal+of+neurophysiology&rft.issn=00223077&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-08-04 N1 - Date created - 2006-06-14 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Race/ethnic differences in the prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68046980; 16650344 AB - Very few large national epidemiologic surveys have examined the prevalence of psychiatric disorders among Asians and Native Americans due to small sample sizes. Very little is also known about the co-occurrences between substance use disorders and mood and anxiety disorders among these two minority groups and how their rates compare to Whites, Blacks, and Hispanics. Analyses were based on a large (n = 43093) nationally representative survey of the adult (18+ years), U.S. population supplemented by a group quarters sampling frame. Prevalences and associations of major DSM-IV mood, anxiety and substance use disorders were examined among all major race/ethnic subgroups of the population. Twelve-month rates of most mood, anxiety and substance use disorders were generally greatest among Native Americans and lowest among Asians. For most race/ethnic subgroups, alcohol and drug dependence, but not abuse, were significantly associated with mood disorders. With few exceptions, there were no significant associations between alcohol and drug abuse and anxiety disorders. In contrast, alcohol dependence was associated with most anxiety disorders among Whites, Blacks and Asians, but not among Native Americans. The 12-month prevalence of substance use, mood, and anxiety disorders varied greatly across the five major race/ethnic subgroups of the population. Twelve-month co-occurrence of substance use disorders and mood and anxiety disorders was pervasive among all race/ethnic subgroups. Future research is also needed to understand race/ethnic differentials in prevalence and co-occurrence of these disorders with a particular focus on factors that may give rise to them. JF - Psychological medicine AU - Smith, Sharon M AU - Stinson, Frederick S AU - Dawson, Deborah A AU - Goldstein, Rise AU - Huang, Boji AU - Grant, Bridget F AD - Laboratory of Epidemiology and Biometry, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 987 EP - 998 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Hispanic Americans KW - Humans KW - European Continental Ancestry Group KW - National Institutes of Health (U.S.) KW - Adult KW - Aged KW - Middle Aged KW - United States -- epidemiology KW - African Continental Ancestry Group KW - Male KW - Comorbidity KW - Prevalence KW - Alcoholism -- epidemiology KW - Ethnic Groups KW - Continental Population Groups KW - Mood Disorders -- epidemiology KW - Anxiety Disorders -- epidemiology KW - Substance-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68046980?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Race%2Fethnic+differences+in+the+prevalence+and+co-occurrence+of+substance+use+disorders+and+independent+mood+and+anxiety+disorders%3A+Results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Smith%2C+Sharon+M%3BStinson%2C+Frederick+S%3BDawson%2C+Deborah+A%3BGoldstein%2C+Rise%3BHuang%2C+Boji%3BGrant%2C+Bridget+F&rft.aulast=Smith&rft.aufirst=Sharon&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=987&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - SuppNotes - Erratum In: Psychol Med. 2008 Apr;38(4):606 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Toward an alcohol use disorder continuum using item response theory: results from the National Epidemiologic Survey on Alcohol and Related Conditions. AN - 68044782; 16563205 AB - Item response theory (IRT) was used to determine whether the DSM-IV diagnostic criteria for alcohol abuse and dependence are arrayed along a continuum of severity. Data came from a large nationally representative sample of the US population, 18 years and older. A two-parameter logistic IRT model was used to determine the severity and discrimination of each DSM-IV criterion. Differential criterion functioning (DCF) was also assessed across subgroups of the population defined by sex, age and race-ethnicity. All DSM-IV alcohol abuse and dependence criteria, except alcohol-related legal problems, formed a continuum of alcohol use disorder severity. Abuse and dependence criteria did not consistently tap the mildest or more severe end of the continuum respectively, and several criteria were identified as potentially redundant. The drinking in larger amounts or for longer than intended dependence criterion had the greatest discrimination and lowest severity than any other criterion. Although several criteria were found to function differentially between subgroups defined in terms of sex and age, there was evidence that the generalizability and validity of the criterion forming the continuum remained intact at the test score level. DSM-IV diagnostic criteria for alcohol abuse and dependence form a continuum of severity, calling into question the abuse-dependence distinction in the DSM-IV and the interpretation of abuse as a milder disorder than dependence. The criteria tapped the more severe end of the alcohol use disorder continuum, highlighting the need to identify other criteria capturing the mild to intermediate range of the severity. The drinking larger amounts or longer than intended dependence criterion may be a bridging criterion between drinking patterns that incur risk of alcohol use disorder at the milder end of the continuum, with tolerance, withdrawal, impaired control and serious social and occupational dysfunction at the more severe end of the alcohol use disorder continuum. Future IRT and other dimensional analyses hold great promise in informing revisions to categorical classifications and constructing new dimensional classifications of alcohol use disorders based on the DSM and the ICD. JF - Psychological medicine AU - Saha, Tulshi D AU - Chou, S Patricia AU - Grant, Bridget F AD - Laboratory of Biometry and Epidemiology, Division of Intramural Clinical and Biological Research, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Department of Health and Human Services, Bethesda, MD 20892-9304, USA. Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 931 EP - 941 VL - 36 IS - 7 SN - 0033-2917, 0033-2917 KW - Index Medicus KW - Diagnosis, Differential KW - Ethnic Groups KW - Humans KW - National Institutes of Health (U.S.) KW - Adult KW - Disease Progression KW - Interviews as Topic KW - Models, Statistical KW - Alcohol Drinking -- epidemiology KW - United States -- epidemiology KW - Male KW - Female KW - Alcoholism -- epidemiology KW - Alcoholism -- diagnosis KW - Alcohol-Related Disorders -- epidemiology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/68044782?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxline&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Psychological+medicine&rft.atitle=Toward+an+alcohol+use+disorder+continuum+using+item+response+theory%3A+results+from+the+National+Epidemiologic+Survey+on+Alcohol+and+Related+Conditions.&rft.au=Saha%2C+Tulshi+D%3BChou%2C+S+Patricia%3BGrant%2C+Bridget+F&rft.aulast=Saha&rft.aufirst=Tulshi&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=931&rft.isbn=&rft.btitle=&rft.title=Psychological+medicine&rft.issn=00332917&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date completed - 2006-11-08 N1 - Date created - 2006-06-05 N1 - Date revised - 2017-01-13 N1 - Last updated - 2017-01-18 ER - TY - JOUR T1 - Staff members are human subjects, too AN - 61615741; 200715606 AB - Top management, clinical supervisors, secretaries, government administrators, counselors, and patients are all examples of informants and agents used by health services researchers as they strive to learn how organizational and managerial factors affect the effectiveness, efficiency, quality, and the cost of substance abuse treatment and prevention services. Patients are clearly a vulnerable population, and researchers in clinical settings, as a rule, strive to protect patient safety and rights to privacy. However, as researchers begin to expand the scope of their study to the organizational contexts in which services are delivered, those responsible for providing services (staff members) are frequently enlisted to serve both as informants on policies and practices, and as participants acting as agents of the researchers in innovating therapeutic and business practices. Researchers need to be mindful that staff members, when acting as informants or as agents, are human subjects, too, and, as such, research procedures should be designed in a manner that minimizes their risk and conforms to sound ethical guidelines. In the interest of stimulating dialogue on ways to protect staff members from unintended harm, this essay overviews human subjects protection policy, describes examples of risks, and offers suggestions for preventing harm when designing studies. [Copyright 2006 Elsevier Inc.] JF - Journal of Substance Abuse Treatment AU - Hilton, Thomas F AD - National Institute on Drug Abuse, Bethesda, MD 20892, USA. Tel.: +1 301 435 0808; fax: +1 301 443 6815 E-mail: tom.hilton@nth.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 9 EP - 15 PB - Elsevier, New York NY VL - 31 IS - 1 SN - 0740-5472, 0740-5472 KW - Human subjects protection, Clinical staff NIH policy Ethics Undue influence, Surveys KW - Professional Ethics KW - Health Professions KW - Substance Abuse KW - Quality of Health Care KW - Patients Rights KW - Organizational Research KW - Delivery Systems KW - Organizational Effectiveness KW - Health Care Services KW - article KW - 0104: methodology and research technology; research methods/tools UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/61615741?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Asocabs&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Substance+Abuse+Treatment&rft.atitle=Staff+members+are+human+subjects%2C+too&rft.au=Hilton%2C+Thomas+F&rft.aulast=Hilton&rft.aufirst=Thomas&rft.date=2006-07-01&rft.volume=31&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Journal+of+Substance+Abuse+Treatment&rft.issn=07405472&rft_id=info:doi/10.1016%2Fj.jsat.2006.03.001 LA - English DB - Sociological Abstracts N1 - Date revised - 2007-08-02 N1 - Number of references - 25 N1 - Last updated - 2016-09-28 N1 - CODEN - JSATEG N1 - SubjectsTermNotLitGenreText - Health Care Services; Health Professions; Organizational Effectiveness; Organizational Research; Patients Rights; Quality of Health Care; Professional Ethics; Substance Abuse; Delivery Systems DO - http://dx.doi.org/10.1016/j.jsat.2006.03.001 ER - TY - JOUR T1 - Broad issues to consider for library involvement in bioinformatics. AN - 57633832; 459567 AB - Background: The information landscape in biological and medical research has grown far beyond literature to include a wide variety of databases generated by research fields such as molecular biology and genomics. The traditional role of libraries to collect, organize, and provide access to information can expand naturally to encompass these new data domains. Methods: This paper discusses the current and potential role of libraries in bioinformatics using empirical evidence and experience from eleven years of work in user services at the National Center for Biotechnology Information. Findings: Medical and science libraries over the last decade have begun to establish educational and support programs to address the challenges users face in the effective and efficient use of a plethora of molecular biology databases and retrieval and analysis tools. As more libraries begin to establish a role in this area, the issues they face include assessment of user needs and skills, identification of existing services, development of plans for new services, recruitment and training of specialized staff, and establishment of collaborations with bioinformatics centres at their institutions. Conclusions: Increasing library involvement in bioinformatics can help address information needs of a broad range of students, researchers, and clinicians and ultimately help realize the power of bioinformatics resources in making new biological discoveries. (Author abstract) JF - Journal of the Medical Library Association ( JMLA ) AU - Geer, Renata C AD - National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA renata@ncbi.nlm.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 PB - Medical Library Association VL - 94 IS - 3 SN - 1536-5050, 1536-5050 KW - Health care KW - Medicine KW - Bioinformatics KW - Computer applications KW - 1.01: LIBRARY AND INFORMATION SCIENCE ELECTRONIC PUBLICATIONS UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57633832?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Alisa&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.atitle=Broad+issues+to+consider+for+library+involvement+in+bioinformatics.&rft.au=Geer%2C+Renata+C&rft.aulast=Geer&rft.aufirst=Renata&rft.date=2006-07-01&rft.volume=94&rft.issue=3&rft.spage=np&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+Medical+Library+Association+%28+JMLA+%29&rft.issn=15365050&rft_id=info:doi/ LA - English DB - Library & Information Science Abstracts (LISA) N1 - Date revised - 2006-11-10 N1 - Document feature - il. refs. N1 - Last updated - 2016-09-27 N1 - SubjectsTermNotLitGenreText - Computer applications; Health care; Medicine; Bioinformatics ER - TY - JOUR T1 - Impaired Decision-Making on the Basis of Both Reward and Punishment Information in Individuals with Psychopathy AN - 57222504; 200612157 AB - In this study, we examined decision-making to rewarding or punishing stimuli in individuals with psychopathy (n = 21) & comparison individuals (n = 19) using the Differential Reward/Punishment Learning Task. In this task, the participant chooses between two objects associated with different levels of reward or punishment. Thus, response choice indexes not only reward/punishment sensitivity but also sensitivity to reward/punishment level according to inter-stimulus reinforcement distance. Individuals with psychopathy showed significant impairment when choosing between objects associated with differential levels of reward but also significantly greater impairment when choosing between objects associated with differential levels of punishment. However, the two groups were comparably affected by inter-stimulus reinforcement distance. The results are discussed with reference to current models of psychopathy. 3 Tables, 1 Figure, 26 References. [Copyright 2006 Elsevier Ltd.] JF - Personality and Individual Differences AU - Blair, K S AU - Morton, J AU - Leonard, A AU - Blair, R J R AD - c/o Blair, R. J. R. -- Unit Affective Cognitive Neuroscience/Mood/Anxiety Disorders Program, National Instit blairj@intra.nimh.nih.gov Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 155 EP - 165 PB - Elsevier, UK VL - 41 IS - 1 SN - 0191-8869, 0191-8869 KW - Psychopathy KW - Decision-making KW - Reward KW - Punishment KW - Decision making KW - Rewards KW - article UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/57222504?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aassia&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Personality+and+Individual+Differences&rft.atitle=Impaired+Decision-Making+on+the+Basis+of+Both+Reward+and+Punishment+Information+in+Individuals+with+Psychopathy&rft.au=Blair%2C+K+S%3BMorton%2C+J%3BLeonard%2C+A%3BBlair%2C+R+J+R&rft.aulast=Blair&rft.aufirst=K&rft.date=2006-07-01&rft.volume=41&rft.issue=1&rft.spage=155&rft.isbn=&rft.btitle=&rft.title=Personality+and+Individual+Differences&rft.issn=01918869&rft_id=info:doi/10.1016%2Fj.paid.2005.11.031 LA - English DB - Applied Social Sciences Index & Abstracts (ASSIA) N1 - Date revised - 2006-08-31 N1 - Last updated - 2016-09-27 N1 - CODEN - PEIDD9 N1 - SubjectsTermNotLitGenreText - Psychopathy; Decision making; Punishment; Rewards DO - http://dx.doi.org/10.1016/j.paid.2005.11.031 ER - TY - JOUR T1 - Liposomal delivery as a mechanism to enhance synergism between anticancer drugs AN - 21298136; 7132408 JF - Molecular Cancer Therapeutics AU - Lee, Robert J AD - Division of Pharmaceutics, College of Pharmacy, National Science Foundation Nanoscale Science and Engineering Center, and National Cancer Institute Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1639 EP - 1640 PB - American Association for Cancer Research, 615 Chestnut St., 17th Floor Philadelphia PA 19106-4404 USA, [URL:http://www.aacr.org/] VL - 5 IS - 7 SN - 1535-7163, 1535-7163 KW - Biotechnology and Bioengineering Abstracts KW - Antitumor agents KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/21298136?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Cancer+Therapeutics&rft.atitle=Liposomal+delivery+as+a+mechanism+to+enhance+synergism+between+anticancer+drugs&rft.au=Lee%2C+Robert+J&rft.aulast=Lee&rft.aufirst=Robert&rft.date=2006-07-01&rft.volume=5&rft.issue=7&rft.spage=1639&rft.isbn=&rft.btitle=&rft.title=Molecular+Cancer+Therapeutics&rft.issn=15357163&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2010-03-01 N1 - Last updated - 2015-03-31 N1 - SubjectsTermNotLitGenreText - Antitumor agents ER - TY - JOUR T1 - Oxidized ATP Protection against Anthrax Lethal Toxin AN - 20986375; 6995773 AB - Bacillus anthracis lethal toxin (LT) induces rapid lysis (<90 min) of murine macrophages from certain inbred strains. The mechanism for LT-induced cytolysis is currently unknown. We hypothesized that the ATP-activated macrophage P2X7 receptors implicated in nucleotide-mediated macrophage lysis could play a role in LT-mediated cytolysis and discovered that a potent P2X7 antagonist, oxidized ATP (o-ATP), protects macrophages against LT. Other P2X7 receptor antagonists, however, had no effect on LT function, while oxidized nucleotides, o-ADP, o-GTP, and o-ITP, which did not act as receptor ligands, provided protection. Cleavage of the LT substrates, the mitogen-activated protein kinases, was inhibited by o-ATP in RAW274.6 macrophages and CHO cells. We investigated the various steps in the intoxication pathway and found that binding of the protective-antigen (PA) component of LT to cells and the enzymatic proteolytic ability of the lethal factor (LF) component of LT were unaffected by o-ATP. Instead, the drug inhibited formation of the sodium dodecyl sulfate-resistant PA oligomer, which occurs in acidified endosomes, but did not prevent cell surface PA oligomerization, as evidenced by binding and translocation of LF to a protease-resistant intracellular location. We found that o-ATP also protected cells from anthrax edema toxin and diphtheria toxin, which also require an acidic environment for escape from endosomes. Confocal microscopy using pH-sensitive fluorescent dyes showed that o-ATP increased endosomal pH. Finally, BALB/cJ mice injected with o-ATP and LT were completely protected against lethality. JF - Infection and Immunity AU - Moayeri, Mahtab AU - Wickliffe, Katherine E AU - Wiggins, Jason F AU - Leppla, Stephen H AD - Microbial Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 3707 EP - 3714 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 74 IS - 7 SN - 0019-9567, 0019-9567 KW - Toxicology Abstracts; Immunology Abstracts; Microbiology Abstracts B: Bacteriology KW - Macrophages KW - Intoxication KW - Proteolysis KW - Cell surface KW - Receptor mechanisms KW - Lethal factor KW - Edema KW - Bacillus anthracis KW - Fluorescent indicators KW - Anthrax KW - Translocation KW - pH effects KW - Drugs KW - Anthrax lethal toxin KW - MAP kinase KW - Oligomerization KW - ATP KW - Nucleotides KW - Diphtheria toxin KW - Sodium KW - endosomes KW - Lethality KW - Purine P2X receptors KW - Confocal microscopy KW - Cytolysis KW - Inbreeding KW - X 24370:Natural Toxins KW - J 02350:Immunology KW - F 06910:Microorganisms & Parasites UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20986375?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Infection+and+Immunity&rft.atitle=Oxidized+ATP+Protection+against+Anthrax+Lethal+Toxin&rft.au=Moayeri%2C+Mahtab%3BWickliffe%2C+Katherine+E%3BWiggins%2C+Jason+F%3BLeppla%2C+Stephen+H&rft.aulast=Moayeri&rft.aufirst=Mahtab&rft.date=2006-07-01&rft.volume=74&rft.issue=7&rft.spage=3707&rft.isbn=&rft.btitle=&rft.title=Infection+and+Immunity&rft.issn=00199567&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Proteolysis; Intoxication; Macrophages; Cell surface; Receptor mechanisms; Lethal factor; Edema; Anthrax; Fluorescent indicators; Drugs; pH effects; Translocation; Anthrax lethal toxin; MAP kinase; Oligomerization; ATP; Diphtheria toxin; Nucleotides; Sodium; endosomes; Lethality; Confocal microscopy; Purine P2X receptors; Cytolysis; Inbreeding; Bacillus anthracis ER - TY - JOUR T1 - N-Terminal Pro-Brain Natriuretic Peptide Levels and Risk of Death in Sickle Cell Disease AN - 20724643; 7128526 AB - CONTEXT: Thirty percent of patients with sickle cell disease (SCD) develop pulmonary hypertension, a major risk factor for death in this population. A validated blood biomarker of pulmonary hypertension in SCD could provide important prognostic and diagnostic information and allow the exploration of the prevalence of pulmonary hypertension in participants in the 1996 Multicenter Study of Hydroxyurea in Sickle Cell Anemia (MSH) Patients' Follow-up Study. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) provide such information in patients with idiopathic pulmonary arterial hypertension. OBJECTIVE: To determine the relationship between NT-proBNP levels and severity of pulmonary hypertension and prospective mortality in patients with SCD. Design, Setting, and Participants NT-proBNP levels were measured in 230 participants in the National Institutes of Health (NIH) Sickle Cell Disease-Pulmonary Hypertension Screening Study (enrollment between February 2001 and March 2005) and in 121 samples from patients enrolled starting in 1996 in the MSH Patients' Follow-up Study. A threshold level predictive of high pulmonary artery pressure and mortality was identified in the NIH Sickle Cell Disease-Pulmonary Hypertension Screening Study and used to define an a priori analytical plan to determine the prevalence and associated mortality of pulmonary hypertension in the MSH follow-up study. MAIN OUTCOME MEASURES: Severity of pulmonary hypertension and risk of all-cause mortality. RESULTS: NT-proBNP levels were higher in patients with sickle cell pulmonary hypertension and correlated directly with tricuspid regurgitant jet velocity in the NIH cohort (R = 0.50, P<.001). An NT-proBNP level of 160 pg/mL or greater had a 78% positive predictive value for the diagnosis of pulmonary hypertension and was an independent predictor of mortality (21 deaths at 31 months' median follow-up; risk ratio, 5.1; 95% confidence interval, 2.1-12.5; P<.001; 19.5% absolute increase in risk of death). In the MSH cohort, 30% of patients had an NT-proBNP level of 160 pg/mL or greater. An NT-proBNP level of 160 pg/mL or greater in the MSH cohort was independently associated with mortality by Cox proportional hazards regression analysis (24 deaths at 47 months' median follow-up; risk ratio, 2.87; 95% confidence interval, 1.2-6.6; P = .02; 11.9% absolute increase in risk of death). CONCLUSIONS: Pulmonary hypertension, as indicated by an NT-proBNP level of 160 pg/mL or greater, was very common in patients in the NIH study and in the MSH cohort. The MSH analysis suggests that rates of vaso-occlusive pain episodes in these patients were unrelated to risk of death; this risk was largely determined by occult hemolytic anemia-associated pulmonary hypertension. JF - JAMA: Journal of the American Medical Association AU - Machado, Roberto F AU - Anthi, Anastasia AU - Steinberg, Martin H AU - Bonds, Duane AU - Sachdev, Vandana AU - Kato, Gregory J AU - Taveira-DaSilva, Angelo M AU - Ballas, Samir K AU - Blackwelder, William AU - Xu, Xiuli AU - Hunter, Lori AU - Barton, Bruce AU - Waclawiw, Myron AU - Castro, Oswaldo AU - Gladwin, Mark T AD - Vascular Medicine Branch (Drs Machado, Anthi, Kato, Xu, and Gladwin and Ms Hunter), Division of Blood Diseases and Resources (Dr Bonds), Cardiovascular Branch (Dr Sachdev), Pulmonary and Critical Care Medicine Branch (Dr Taveira-DaSilva), and Office of Biostatistics Research (Dr Waclawiw), National Heart, Lung, and Blood Institute, and Critical Care Medicine Department, Clinical Center (Drs Machado, Anthi, Blackwelder, Kato, Xu, and Gladwin and Ms Hunter), National Institutes of Health, Bethesda, Md Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 310 EP - 318 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 296 IS - 3 SN - 0098-7484, 0098-7484 KW - Risk Abstracts; CSA Neurosciences Abstracts KW - Bioindicators KW - Mortality KW - anemia KW - Hydroxyurea KW - Lung diseases KW - pain KW - Velocity KW - Pain KW - biomarkers KW - Blood KW - Lung KW - Pulmonary artery KW - Risk factors KW - hypertension KW - Sickle cell disease KW - Hypertension KW - R2 23060:Medical and environmental health KW - N3 11027:Neurology & neuropathology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20724643?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=N-Terminal+Pro-Brain+Natriuretic+Peptide+Levels+and+Risk+of+Death+in+Sickle+Cell+Disease&rft.au=Machado%2C+Roberto+F%3BAnthi%2C+Anastasia%3BSteinberg%2C+Martin+H%3BBonds%2C+Duane%3BSachdev%2C+Vandana%3BKato%2C+Gregory+J%3BTaveira-DaSilva%2C+Angelo+M%3BBallas%2C+Samir+K%3BBlackwelder%2C+William%3BXu%2C+Xiuli%3BHunter%2C+Lori%3BBarton%2C+Bruce%3BWaclawiw%2C+Myron%3BCastro%2C+Oswaldo%3BGladwin%2C+Mark+T&rft.aulast=Machado&rft.aufirst=Roberto&rft.date=2006-07-01&rft.volume=296&rft.issue=3&rft.spage=310&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Blood; Mortality; Hydroxyurea; Lung; Risk factors; Pulmonary artery; Lung diseases; Pain; biomarkers; Sickle cell disease; Hypertension; Bioindicators; anemia; hypertension; Velocity; pain ER - TY - JOUR T1 - The sialotranscriptome of adult male Anopheles gambiae mosquitoes AN - 20722135; 7043903 AB - Adult mosquitoes feed on sugary meals to obtain energy for flight and other activities, while anautogenous females take a blood meal to develop eggs. Accordingly, female but not male salivary glands possess several antihemostatic components to facilitate acquisition of blood, while both sexes have activities related to digestion of the sugar meal as well as antimicrobials to maintain meal integrity. Studies on adult female sialotranscriptomes indicated a set of ~70 proteins and peptides possibly secreted in saliva that presumably facilitate sugar and blood meals. Most of these proteins have no known function, so no assignment to blood or sugar feeding is possible. Microarray and RT-PCR studies attempted to identify sex specificity of these transcripts. Our present study complements the previous data set, comparing ~1000 randomly sequenced clones of a male adult salivary gland cDNA library with the female set. Statistically significant differences were found in 16 transcripts found exclusively in the female library, 4 transcripts significantly female enriched but also found in male glands, and 6 transcripts enriched in male glands. We additionally found a transcript in male salivary glands with a trypsin inhibitor-like (TIL) domain that we presume codes for an antimicrobial peptide; a novel defensin transcript was also found in the male sialotranscriptome. Supplemental tables can be found at http:/ /www.ncbi.nlm.nih.gov/projects/omes/ JF - Insect Biochemistry and Molecular Biology AU - Calvo, E AU - Pham, V M AU - Lombardo, F AU - Arca, B AU - Ribeiro, JMC AD - Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Room 2E-32D, Rockville, MD 20852, USA, jribeiro@niaid.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 570 EP - 575 VL - 36 IS - 7 SN - 0965-1748, 0965-1748 KW - Mosquitoes KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Entomology Abstracts KW - Feeding KW - Sugar KW - Data processing KW - Trypsin KW - Statistical analysis KW - Culicidae KW - Blood meals KW - Sex differences KW - Salivary gland KW - DNA microarrays KW - Anopheles gambiae KW - Eggs KW - Antimicrobial agents KW - Digestion KW - Flight KW - Blood KW - Defensins KW - Energy KW - Polymerase chain reaction KW - Saliva KW - Antimicrobial peptides KW - Sex KW - A 01340:Antibiotics & Antimicrobials KW - Z 05350:Medical, Veterinary, and Agricultural Entomology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20722135?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologya&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Insect+Biochemistry+and+Molecular+Biology&rft.atitle=The+sialotranscriptome+of+adult+male+Anopheles+gambiae+mosquitoes&rft.au=Calvo%2C+E%3BPham%2C+V+M%3BLombardo%2C+F%3BArca%2C+B%3BRibeiro%2C+JMC&rft.aulast=Calvo&rft.aufirst=E&rft.date=2006-07-01&rft.volume=36&rft.issue=7&rft.spage=570&rft.isbn=&rft.btitle=&rft.title=Insect+Biochemistry+and+Molecular+Biology&rft.issn=09651748&rft_id=info:doi/10.1016%2Fj.ibmb.2006.04.005 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Sugar; Feeding; Data processing; Trypsin; Statistical analysis; Blood meals; Salivary gland; Sex differences; DNA microarrays; Eggs; Antimicrobial agents; Flight; Digestion; Blood; Defensins; Energy; Polymerase chain reaction; Saliva; Antimicrobial peptides; Sex; Culicidae; Anopheles gambiae DO - http://dx.doi.org/10.1016/j.ibmb.2006.04.005 ER - TY - JOUR T1 - Origin inactivation in bacterial DNA replication control AN - 20630848; 6961431 AB - Initiation of DNA replication is a highly regulated process in all organisms. Proteins that are required to recruit DNA polymerase - initiator proteins - are often used to regulate the timing or frequency of initiation in the cell cycle by limiting either their own synthesis or availability. Studies of the Escherichia coli chromosome and of bacterial plasmids with iterated initiator binding sites (iterons) have revealed that, in addition to initiator limitation, replication origin inactivation is used to prevent replication that is untimely or excessive. Our recent studies of plasmid P1 revealed that this additional mode of control becomes a requirement when initiator availability is limited only by autoregulation. Thus, although initiator limitation appears to be a well-conserved and central mode of replication control, optimal replication might require additional control mechanisms. This review gives examples of how the multiple mechanisms can act synergistically, antagonistically or be partially redundant to guarantee low frequency events. The lessons learned are likely to help understand many other regulatory systems in the bacterial cell. JF - Molecular Microbiology AU - Paulsson, Johan AU - Chattoraj, Dhruba K AD - Laboratory of Biochemistry, NCI, NIH, Bethesda, MD 20892-4255, USA, chattord@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 9 EP - 15 PB - Blackwell Publishing Ltd., 9600 Garsington Road Oxford OX4 2DQ UK, [URL:http://www.blackwellpublishing.com] VL - 61 IS - 1 SN - 0950-382X, 0950-382X KW - Microbiology Abstracts A: Industrial & Applied Microbiology; Biochemistry Abstracts 2: Nucleic Acids; Microbiology Abstracts B: Bacteriology KW - DNA biosynthesis KW - Chromosomes KW - Replication initiation KW - Replication KW - DNA-directed DNA polymerase KW - Reviews KW - Cell cycle KW - Escherichia coli KW - Replication origins KW - Plasmids KW - J 02310:Genetics & Taxonomy KW - A 01490:Miscellaneous KW - N 14820:DNA Metabolism & Structure UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20630848?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Molecular+Microbiology&rft.atitle=Origin+inactivation+in+bacterial+DNA+replication+control&rft.au=Paulsson%2C+Johan%3BChattoraj%2C+Dhruba+K&rft.aulast=Paulsson&rft.aufirst=Johan&rft.date=2006-07-01&rft.volume=61&rft.issue=1&rft.spage=9&rft.isbn=&rft.btitle=&rft.title=Molecular+Microbiology&rft.issn=0950382X&rft_id=info:doi/10.1111%2Fj.1365-2958.2006.05229.x LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - SuppNotes - Figures, 1; references, 48. N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - DNA biosynthesis; Chromosomes; Replication initiation; Replication; Reviews; DNA-directed DNA polymerase; Cell cycle; Replication origins; Plasmids; Escherichia coli DO - http://dx.doi.org/10.1111/j.1365-2958.2006.05229.x ER - TY - JOUR T1 - Regulation of the Chlamydia trachomatis Histone H1-Like Protein Hc2 Is IspE Dependent and IhtA Independent AN - 20247193; 6996275 AB - The chlamydial histone-like proteins, Hc1 and Hc2, function as global regulators of chromatin structure and gene expression. Hc1 and Hc2 expression and activity are developmentally regulated. A small metabolite that disrupts Hc1 interaction with DNA also disrupts Hc2 interactions; however, the small regulatory RNA that inhibits Hc1 translation is specific to Hc1. JF - Journal of Bacteriology AU - Grieshaber, Nicole A AU - Sager, Janet Burgess AU - Dooley, Cheryl A AU - Hayes, Stanley F AU - Hackstadt, Ted AD - Host-Parasite Interactions Section, Laboratory of Intracellular Parasites, NIAID, NIH, Rocky Mountain Laboratories, Hamilton, Montana 59840 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 5289 EP - 5292 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 188 IS - 14 SN - 0021-9193, 0021-9193 KW - IhtA protein KW - IspE protein KW - Biochemistry Abstracts 2: Nucleic Acids; Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Gene expression KW - Translation KW - Histones KW - RNA KW - Chromatin KW - DNA KW - Chlamydia trachomatis KW - Metabolites KW - J 02310:Genetics & Taxonomy KW - N 14820:DNA Metabolism & Structure KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/20247193?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Bacteriology&rft.atitle=Regulation+of+the+Chlamydia+trachomatis+Histone+H1-Like+Protein+Hc2+Is+IspE+Dependent+and+IhtA+Independent&rft.au=Grieshaber%2C+Nicole+A%3BSager%2C+Janet+Burgess%3BDooley%2C+Cheryl+A%3BHayes%2C+Stanley+F%3BHackstadt%2C+Ted&rft.aulast=Grieshaber&rft.aufirst=Nicole&rft.date=2006-07-01&rft.volume=188&rft.issue=14&rft.spage=5289&rft.isbn=&rft.btitle=&rft.title=Journal+of+Bacteriology&rft.issn=00219193&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Gene expression; Translation; Histones; Chromatin; RNA; DNA; Metabolites; Chlamydia trachomatis ER - TY - JOUR T1 - The Defined Combination of Growth Factors Controls Generation of Long-Term-Replicating Islet Progenitor-Like Cells from Cultures of Adult Mouse Pancreas AN - 19975784; 6999344 AB - Application of pancreatic islet transplantation to treatment of diabetes is severely hampered by the inadequate islet supply. This problem could in principle be overcome by generating islet cells from adult pancreas in vitro. Although it is possible to obtain replicating cells from cultures of adult pancreas, these cells, when significantly expanded in vitro, progressively lose pancreatic-specific gene expression, including that of a "master" homeobox transcription factor Pdx1. Here we show for the first time that long-term proliferating islet progenitor-like cells (IPLCs) stably expressing high levels of Pdx1 and other genes that control early pancreatic development can be derived from cultures of adult mouse pancreas under serum-free defined culture conditions. Moreover, we show that cells derived thus can be maintained in continuous culture for at least 6 months without any substantial loss of early pancreatic phenotype. Upon growth factor withdrawal, the IPLCs organize into cell clusters and undergo endocrine differentiation of various degrees in a line-dependent manner. We propose that our experimental strategy will provide a framework for developing efficient approaches for ex vivo expansion of islet cell mass. JF - Stem Cells AU - Ta, Malancha AU - Choi, Yong AU - Atouf, Fouad AU - Park, Cheol Hong AU - Lumelsky, Nadya AD - Islet and Autoimmunity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1738 EP - 1749 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Transplantation KW - Pancreas KW - Homeobox KW - Islet cells KW - Islets of Langerhans KW - Cell culture KW - Diabetes mellitus KW - Gene expression KW - Differentiation KW - Stem cells KW - Continuous culture KW - Transcription factors KW - Allografts KW - Growth factors KW - Pancreatic islet transplantation KW - G 07730:Development & Cell Cycle KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19975784?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=The+Defined+Combination+of+Growth+Factors+Controls+Generation+of+Long-Term-Replicating+Islet+Progenitor-Like+Cells+from+Cultures+of+Adult+Mouse+Pancreas&rft.au=Ta%2C+Malancha%3BChoi%2C+Yong%3BAtouf%2C+Fouad%3BPark%2C+Cheol+Hong%3BLumelsky%2C+Nadya&rft.aulast=Ta&rft.aufirst=Malancha&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1738&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Transplantation; Pancreas; Cell culture; Islets of Langerhans; Islet cells; Homeobox; Gene expression; Diabetes mellitus; Differentiation; Stem cells; Continuous culture; Transcription factors; Allografts; Pancreatic islet transplantation; Growth factors ER - TY - JOUR T1 - Identification and Functional Analysis of Candidate Genes Regulating Mesenchymal Stem Cell Self-Renewal and Multipotency AN - 19959893; 6999341 AB - Adult human mesenchymal stem cells (hMSCs) possess multilineage differentiation potential, and differentiated hMSCs have recently been shown to have the ability to transdifferentiate into other lineages. However, the molecular signature of hMSCs is not well-known, and the mechanisms regulating their self-renewal, differentiation, and transdifferentiation are not completely understood. In this study, we demonstrate that fully differentiated hMSCs could dedifferentiate, a likely critical step for transdifferentiation. By comparing the global gene expression profiles of undifferentiated, differentiated, and dedifferentiation cells in three mesenchymal lineages (osteogenesis, chondrogenesis, and adipogenesis), we identified a number of "stemness" and "differentiation" genes that might be essential to maintain adult stem cell multipotency as well as to drive lineage-specific commitment. These genes include those that encode cell surface molecules, as well as components of signaling pathways. These genes may be valuable for developing methods to isolate, enrich, and purify homogeneous population of hMSCs and/or maintain and propagate hMSCs as well as guide or regulate their differentiation for gene and cell-based therapy. Using small interfering RNA gene inactivation, we demonstrate that five genes (actin filament-associated protein, frizzled 7, dickkopf 3, protein tyrosine phosphatase receptor F, and RAB3B) promote cell survival without altering cell proliferation, as well as exhibiting different effects on the commitment of hMSCs into multiple mesenchymal lineages. JF - Stem Cells AU - Song, Lin AU - Webb, Nicole E AU - Song, Yingjie AU - Tuan, Rocky S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1707 EP - 1718 PB - AlphaMed Press, Inc., One Prestige Pl, Ste 290 Miamisburg OH 45342-3758 USA VL - 24 IS - 7 SN - 1066-5099, 1066-5099 KW - Genetics Abstracts; Biotechnology and Bioengineering Abstracts KW - Cell survival KW - Cell surface KW - Frizzled protein KW - Protein-tyrosine-phosphatase KW - Gene expression KW - Stem cells KW - siRNA KW - Actin KW - Cell proliferation KW - Mesenchyme KW - adipogenesis KW - Chondrogenesis KW - Osteogenesis KW - Signal transduction KW - W 30940:Products KW - G 07730:Development & Cell Cycle UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19959893?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Stem+Cells&rft.atitle=Identification+and+Functional+Analysis+of+Candidate+Genes+Regulating+Mesenchymal+Stem+Cell+Self-Renewal+and+Multipotency&rft.au=Song%2C+Lin%3BWebb%2C+Nicole+E%3BSong%2C+Yingjie%3BTuan%2C+Rocky+S&rft.aulast=Song&rft.aufirst=Lin&rft.date=2006-07-01&rft.volume=24&rft.issue=7&rft.spage=1707&rft.isbn=&rft.btitle=&rft.title=Stem+Cells&rft.issn=10665099&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell survival; Cell surface; Frizzled protein; Protein-tyrosine-phosphatase; Gene expression; Stem cells; siRNA; Actin; adipogenesis; Mesenchyme; Cell proliferation; Signal transduction; Osteogenesis; Chondrogenesis ER - TY - JOUR T1 - Analysis of TLR4 Polymorphic Variants: New Insights into TLR4/MD-2/CD14 Stoichiometry, Structure, and Signaling AN - 19848452; 6997085 AB - TLR4 is the signal-transducing receptor for structurally diverse microbial molecules such as bacterial LPS, respiratory syncytial virus fusion (F) protein, and chlamydial heat shock protein 60. Previous studies associated two polymorphic mutations in the extracellular domain of TLR4 (Asp super(299)Gly and Thr super(399)Ile) with decreased LPS responsiveness. To analyze the molecular basis for diminished responsiveness, site-specific mutations (singly or coexpressed) were introduced into untagged and epitope (Flag)-tagged wild-type (WT) TLR4 expression vectors to permit a direct comparison of WT and mutant signal transduction. Coexpression of WT TLR4, CD14, and MD-2 expression vectors in HEK293T cells was first optimized to achieve optimal LPS-induced NF- Kappa B reporter gene expression. Surprisingly, transfection of cells with MD-2 at high input levels often used in the literature suppressed LPS-induced signaling, whereas supraoptimal CD14 levels did not. Under conditions where WT and polymorphic variants were comparably expressed, significant differences in NF- Kappa B activation were observed in response to LPS and two structurally unrelated TLR4 agonists, chlamydial heat shock protein 60 and RSV F protein, with the double, cosegregating mutant TLR4 exhibiting the greatest deficiency. Overexpression of Flag-tagged WT and mutant vectors at input levels resulting in agonist-independent signaling led to equivalent NF- Kappa B signaling, suggesting that these mutations in TLR4 affect appropriate interaction with agonist or coreceptor. These data provide new insights into the importance of stoichiometry among the components of the TLR4/MD-2/CD14 complex. A structural model that accounts for the diminished responsiveness of mutant TLR4 polymorphisms to structurally unrelated TLR4 agonists is proposed. JF - Journal of Immunology AU - Rallabhandi, Prasad AU - Bell, Jessica AU - Boukhvalova, Marina S AU - Medvedev, Andrei AU - Lorenz, Eva AU - Arditi, Moshe AU - Hemming, Val G AU - Blanco, Jorge CG AU - Segal, David M AU - Vogel, Stefanie N AD - Department of Microbiology and Immunology, University of Maryland, Baltimore, MD 21201, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health (NIH), Bethesda, MD 20814. Virion Systems, Rockville, MD 20850. Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC 27599. Pediatric Infectious Diseases, Cedars Sinai Medical Center, Los Angeles, CA 90048. Experimental Immunology Branch, National Cancer Institute, NIH, Bethesda, MD 20814 Y1 - 2006/07/01/ PY - 2006 DA - 2006 Jul 01 SP - 322 EP - 332 PB - American Association of Immunologists, 9650 Rockville Pike Bethesda MD 20814-3998 USA, [URL:http://www.jimmunol.org/] VL - 177 IS - 1 SN - 0022-1767, 0022-1767 KW - Microbiology Abstracts B: Bacteriology; Virology & AIDS Abstracts; Immunology Abstracts KW - Data processing KW - F protein KW - CD14 antigen KW - NF- Kappa B protein KW - double prime F protein KW - Respiratory syncytial virus KW - Expression vectors KW - HSP60 protein KW - Transfection KW - Reporter gene KW - MD-2 protein KW - Hsp60 protein KW - Lipopolysaccharides KW - Fusion protein KW - Mutation KW - TLR4 protein KW - Epitopes KW - Toll-like receptors KW - Signal transduction KW - V 22350:Immunology KW - J 02350:Immunology KW - F 06640:Other: defensins, antimicrobial peptides UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19848452?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Analysis+of+TLR4+Polymorphic+Variants%3A+New+Insights+into+TLR4%2FMD-2%2FCD14+Stoichiometry%2C+Structure%2C+and+Signaling&rft.au=Rallabhandi%2C+Prasad%3BBell%2C+Jessica%3BBoukhvalova%2C+Marina+S%3BMedvedev%2C+Andrei%3BLorenz%2C+Eva%3BArditi%2C+Moshe%3BHemming%2C+Val+G%3BBlanco%2C+Jorge+CG%3BSegal%2C+David+M%3BVogel%2C+Stefanie+N&rft.aulast=Rallabhandi&rft.aufirst=Prasad&rft.date=2006-07-01&rft.volume=177&rft.issue=1&rft.spage=322&rft.isbn=&rft.btitle=&rft.title=Journal+of+Immunology&rft.issn=00221767&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Data processing; F protein; CD14 antigen; double prime F protein; NF- Kappa B protein; Expression vectors; HSP60 protein; Reporter gene; Transfection; Hsp60 protein; MD-2 protein; Lipopolysaccharides; Fusion protein; TLR4 protein; Mutation; Toll-like receptors; Epitopes; Signal transduction; Respiratory syncytial virus ER - TY - JOUR T1 - Opinion: Chromatin in pluripotent embryonic stem cells and differentiation AN - 19778249; 6964004 AB - Embryonic stem (ES) cells are unique in that they are pluripotent and have the ability to self-renew. The molecular mechanisms that underlie these two fundamental properties are largely unknown. We discuss how unique properties of chromatin in ES cells contribute to the maintenance of pluripotency and the determination of differentiation properties. JF - Nature Reviews: Molecular Cell Biology AU - Meshorer, Eran AU - Misteli, Tom AD - Eran Meshorer and Tom Misteli are at the National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.,; ] meshoree@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 540 EP - 546 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 7 IS - 7 SN - 1471-0072, 1471-0072 KW - Biotechnology and Bioengineering Abstracts; Biochemistry Abstracts 2: Nucleic Acids KW - Differentiation KW - Molecular modelling KW - Stem cells KW - Chromatin KW - Embryo cells KW - Reviews KW - Embryos KW - N 14820:DNA Metabolism & Structure KW - W 30965:Miscellaneous, Reviews UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19778249?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Reviews%3A+Molecular+Cell+Biology&rft.atitle=Opinion%3A+Chromatin+in+pluripotent+embryonic+stem+cells+and+differentiation&rft.au=Meshorer%2C+Eran%3BMisteli%2C+Tom&rft.aulast=Meshorer&rft.aufirst=Eran&rft.date=2006-07-01&rft.volume=7&rft.issue=7&rft.spage=540&rft.isbn=&rft.btitle=&rft.title=Nature+Reviews%3A+Molecular+Cell+Biology&rft.issn=14710072&rft_id=info:doi/10.1038%2Fnrm1938 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Differentiation; Stem cells; Embryo cells; Chromatin; Reviews; Embryos DO - http://dx.doi.org/10.1038/nrm1938 ER - TY - JOUR T1 - 30S ribosomal subunits can be assembled in vivo without primary binding ribosomal protein S15 AN - 19770699; 6999201 AB - Assembly of 30S ribosomal subunits from Escherichia coli has been dissected in detail using an in vitro system. Such studies have allowed characterization of the role for ribosomal protein S15 in the hierarchical assembly of 30S subunits; S15 is a primary binding protein that orchestrates the assembly of ribosomal proteins S6, S11, S18, and S21 with the central domain of 16S ribosomal RNA to form the platform of the 30S subunit. In vitro S15 is the sole primary binding protein in this cascade, performing a critical role during assembly of these four proteins. To investigate the role of S15 in vivo, the essential nature of rpsO, the gene encoding S15, was examined. Surprisingly, E. coli with an in-frame deletion of rpsO are viable, although at 37 degree C this Delta rpsO strain has an exaggerated doubling time compared to its parental strain. In the absence of S15, the remaining four platform proteins are assembled into ribosomes in vivo, and the overall architecture of the 30S subunits formed in the Delta rpsO strain at 37 degree C is not altered. Nonetheless, 30S subunits lacking S15 appear to be somewhat defective in subunit association in vivo and in vitro. In addition, this strain is cold sensitive, displaying a marked ribosome biogenesis defect at low temperature, suggesting that under nonideal conditions S15 is critical for assembly. The viability of this strain indicates that in vivo functional populations of 70S ribosomes must form in the absence of S15 and that 30S subunit assembly has a plasicity that has not previously been revealed or characterized. JF - RNA AU - Bubunenko, Mikhail AU - Korepanov, Alexey AU - Court, Donald L AU - Jagannathan, Indu AU - Dickinson, Daniel AU - Chaudhuri, Biswajoy Roy AU - Garber, Maria B AU - Culver, Gloria M AD - Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Molecular Control and Genetics Section, Gene Regulation and Chromosome Biology Laboratory, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland 21702, USA. Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russian Federation. Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1229 EP - 1239 PB - Cold Spring Harbor Laboratory Press, Fulfillment & Distribution Dept. 500 Sunnyside Boulevard Woodbury NY 11797-2924 USA, [mailto:cshpress@cshl.org], [URL:http://www.cshl.org/] VL - 12 IS - 7 SN - 1355-8382, 1355-8382 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Temperature effects KW - Gene deletion KW - ribosomal protein S6 KW - Escherichia coli KW - Ribosomes KW - Ribosomal subunits KW - rRNA 16S KW - Ribosomal protein S15 KW - Evolution KW - J 02410:Animal Diseases KW - N 14830:RNA UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19770699?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=RNA&rft.atitle=30S+ribosomal+subunits+can+be+assembled+in+vivo+without+primary+binding+ribosomal+protein+S15&rft.au=Bubunenko%2C+Mikhail%3BKorepanov%2C+Alexey%3BCourt%2C+Donald+L%3BJagannathan%2C+Indu%3BDickinson%2C+Daniel%3BChaudhuri%2C+Biswajoy+Roy%3BGarber%2C+Maria+B%3BCulver%2C+Gloria+M&rft.aulast=Bubunenko&rft.aufirst=Mikhail&rft.date=2006-07-01&rft.volume=12&rft.issue=7&rft.spage=1229&rft.isbn=&rft.btitle=&rft.title=RNA&rft.issn=13558382&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Temperature effects; Gene deletion; ribosomal protein S6; Ribosomal subunits; Ribosomes; rRNA 16S; Evolution; Ribosomal protein S15; Escherichia coli ER - TY - JOUR T1 - The Utility of the Guppy (Poecilia reticulata) and Medaka (Oryzias latipes) in Evaluation of Chemicals for Carcinogenicity AN - 19671384; 6999473 AB - There has been considerable interest in the use of small fish models for detecting potential environmental carcinogens. In this study, both guppies (Poecilia reticulata) and medaka (Oryzias latipes) were exposed in the aquaria water to three known rodent carcinogens for up to 16 months. Nitromethane, which caused mammary gland tumors by inhalation exposure in female rats, harderian gland and lung tumors in male and female mice, and liver tumors in female mice by inhalation, failed to increase tumors in either guppies or medaka. Propanediol, which when given in the feed was a multisite carcinogen in both sexes of rats and mice, caused increased liver tumors in male guppies and male medaka. There was reduced survival in female guppies and no increased tumors in female medaka. 1,2,3-Trichloropropane, which when administered by oral gavage was a multisite carcinogen in both sexes of rats and mice, caused an increased incidence of tumors in the liver of both male and female guppies and medaka and in the gallbladder of male and female medaka. The results of this study demonstrate that for these three chemicals, under these specific exposure conditions, the fish appear less sensitive and have a narrower spectrum of tissues affected than rodents. These results suggest that fish models are of limited utility in screening unknown chemicals for potential carcinogenicity. JF - Toxicological Sciences AU - Kissling, Grace E AU - Bernheim, Naomi J AU - Hawkins, William E AU - Wolfe, Marilyn J AU - Jokinen, Micheal P AU - Smith, Cynthia S AU - Herbert, Ronald A AU - Boorman, Gary A AD - Environmental Medicine and Diseases Program and Environmental Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 Y1 - 2006/07// PY - 2006 DA - July 2006 SP - 143 EP - 156 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk] VL - 92 IS - 1 SN - 1096-6080, 1096-6080 KW - Guppy KW - Medaka KW - Millions fish KW - Rainbowfish KW - Pollution Abstracts; ASFA 3: Aquatic Pollution & Environmental Quality; Toxicology Abstracts KW - Inhalation KW - Poecilia reticulata KW - Oryzias latipes KW - Animal models KW - Survival KW - Pollution effects KW - Carcinogens KW - Freshwater KW - Freshwater fish KW - Toxicity tests KW - Models KW - Aquaria KW - Carcinogenicity KW - Chemical pollution KW - Screening KW - Mammary gland KW - Harderian gland KW - Gallbladder KW - Lung KW - Fish physiology KW - Liver KW - Toxicity testing KW - Tumours KW - Q5 08504:Effects on organisms KW - P 6000:TOXICOLOGY AND HEALTH KW - X 24300:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19671384?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aasfaaquaticpollution&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Toxicological+Sciences&rft.atitle=The+Utility+of+the+Guppy+%28Poecilia+reticulata%29+and+Medaka+%28Oryzias+latipes%29+in+Evaluation+of+Chemicals+for+Carcinogenicity&rft.au=Kissling%2C+Grace+E%3BBernheim%2C+Naomi+J%3BHawkins%2C+William+E%3BWolfe%2C+Marilyn+J%3BJokinen%2C+Micheal+P%3BSmith%2C+Cynthia+S%3BHerbert%2C+Ronald+A%3BBoorman%2C+Gary+A&rft.aulast=Kissling&rft.aufirst=Grace&rft.date=2006-07-01&rft.volume=92&rft.issue=1&rft.spage=143&rft.isbn=&rft.btitle=&rft.title=Toxicological+Sciences&rft.issn=10966080&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2016-05-27 N1 - SubjectsTermNotLitGenreText - Screening; Fish physiology; Pollution effects; Carcinogens; Freshwater fish; Toxicity tests; Tumours; Aquaria; Inhalation; Gallbladder; Lung; Mammary gland; Carcinogenicity; Harderian gland; Animal models; Liver; Survival; Models; Chemical pollution; Toxicity testing; Poecilia reticulata; Oryzias latipes; Freshwater ER - TY - JOUR T1 - In Vivo Spectral Fluorescence Imaging of Submillimeter Peritoneal Cancer Implants Using a Lectin-Targeted Optical Agent AN - 19622489; 7354230 AB - Intraperitoneal metastases commonly recur after surgery because small tumor foci escape detection within the complex anatomy of the peritoneal cavity and mesentery. Accurate localization of peritoneal implants during surgery could improve the resection of ovarian cancer and other malignancies, but few practical techniques to enhance detectability are currently available. Here, we describe a targeted molecular imaging method that employs fluorescently labeled avidin to detect submillimeter peritoneal implants of ovarian cancer in mice. After binding to surface lectins on the tumor, fluorescein-conjugated avidin enabled the spectral fluorescence imaging of disseminated peritoneal implants. High spatial resolution and high tumor-to-background ratio allowed the visualization of implants as small as 0.3 mm (with 100% sensitivity and specificity; n = 150) and the identification of even smaller lesions ex vivo. These results suggest that targeted molecular imaging with a fluorescence-labeled lectin-ligand system is a promising technique for the detection of disseminated submillimeter foci of cancer. JF - Neoplasia AU - Hama, Y AU - Urano, Y AU - Koyama, Y AU - Kamiya, M AU - Bernardo, M AU - Paik, R S AU - Krishna, M C AU - Choyke, P L AU - Kobayashi, H AD - Molecular Imaging Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1088, USA, kobayash@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 607 EP - 612 VL - 8 IS - 7 SN - 1522-8002, 1522-8002 KW - Biotechnology and Bioengineering Abstracts KW - Metastases KW - Avidin KW - Ovarian cancer KW - Malignancy KW - Fluorescence KW - Mesentery KW - Surgery KW - Peritoneum KW - Lectins KW - Tumors KW - imaging KW - W 30920:Tissue Engineering UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19622489?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Neoplasia&rft.atitle=In+Vivo+Spectral+Fluorescence+Imaging+of+Submillimeter+Peritoneal+Cancer+Implants+Using+a+Lectin-Targeted+Optical+Agent&rft.au=Hama%2C+Y%3BUrano%2C+Y%3BKoyama%2C+Y%3BKamiya%2C+M%3BBernardo%2C+M%3BPaik%2C+R+S%3BKrishna%2C+M+C%3BChoyke%2C+P+L%3BKobayashi%2C+H&rft.aulast=Hama&rft.aufirst=Y&rft.date=2006-07-01&rft.volume=8&rft.issue=7&rft.spage=607&rft.isbn=&rft.btitle=&rft.title=Neoplasia&rft.issn=15228002&rft_id=info:doi/10.1593%2Fneo.06268 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-07-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Metastases; Ovarian cancer; Avidin; Malignancy; Fluorescence; Mesentery; Surgery; Peritoneum; Lectins; Tumors; imaging DO - http://dx.doi.org/10.1593/neo.06268 ER - TY - JOUR T1 - Asthma and body weight change: a 20-year prospective community study of young adults AN - 19492024; 7189323 AB - Objective: There is increasing evidence for an association between asthma and body weight change. The objectives of these analyses were to examine the temporal relationships of this association and to explore the role of childhood depression as an explanatory factor. Methods: Data were derived from six subsequent semistructured interviews on health habits and health conditions from a single-age community study of 591 young adults followed up between ages 20 and 40 years. Results: Cross-sectionally (over the whole study period), asthma was significantly associated with obesity (odds ratio = 3.9 [95% confidence interval 1.2, 12.2]). Multivariate longitudinal analyses revealed that asthma was associated with increased later weight gain and later obesity among women after controlling for potentially confounding variables, whereas weight gain and obesity were not associated with later asthma. A secondary analysis showed that depressive symptoms during childhood were associated with adult obesity and asthma, partially explaining the asthma-obesity comorbidity. Conclusion: This study encourages further research on mechanisms underlying the asthma-obesity comorbidity, particularly on shared psychosocial factors operating during critical periods in childhood and adolescence that may influence the development and persistence of both obesity and asthma during adulthood. JF - International Journal of Obesity AU - Hasler, G AU - Gergen, P J AU - Ajdacic, V AU - Gamma, A AU - Eich, D AU - Roessler, W AU - Angst, J AD - Mood and Anxiety Disorders Program, Intramural Research Program, National Institutes of Health, National Institute of Mental Health, 15K North Drive, Room 200, MSC 2670, Bethesda, MD 20892-2670, USA, gregor.hasler@usz.ch Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1111 EP - 1118 VL - 30 IS - 7 SN - 0307-0565, 0307-0565 KW - Physical Education Index KW - Obesity KW - Depression KW - Adolescence KW - Women KW - Asthma KW - Health KW - Adults KW - Weight KW - Objectives KW - Analysis KW - Psychosocial factors KW - Interviews KW - Youth KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19492024?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Obesity&rft.atitle=Asthma+and+body+weight+change%3A+a+20-year+prospective+community+study+of+young+adults&rft.au=Hasler%2C+G%3BGergen%2C+P+J%3BAjdacic%2C+V%3BGamma%2C+A%3BEich%2C+D%3BRoessler%2C+W%3BAngst%2C+J&rft.aulast=Hasler&rft.aufirst=G&rft.date=2006-07-01&rft.volume=30&rft.issue=7&rft.spage=1111&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Obesity&rft.issn=03070565&rft_id=info:doi/10.1038%2Fsj.ijo.0803215 LA - English DB - Physical Education Index N1 - Date revised - 2007-05-01 N1 - Last updated - 2015-04-01 N1 - SubjectsTermNotLitGenreText - Obesity; Depression; Adolescence; Women; Asthma; Health; Adults; Weight; Analysis; Objectives; Interviews; Psychosocial factors; Youth DO - http://dx.doi.org/10.1038/sj.ijo.0803215 ER - TY - JOUR T1 - Separating respiratory-variation-related fluctuations from neuronal- activity-related fluctuations in fMRI AN - 19447137; 6931171 AB - Subtle changes in a subject's breathing rate or depth, which occur naturally during rest at low frequencies (-0.1 Hz), have been shown to be significantly correlated with fMRI signal changes throughout gray matter and near large vessels. The goal of this study was to investigate the impact of these low- frequency respiration variations on both task activation fMRI studies and resting-state functional connectivity analysis. Unlike MR signal changes correlated with the breathing motion (0.3 Hz), BOLD signal changes correlated with across-breath variations in respiratory volume (0.03 Hz) appear localized to blood vessels and regions with high blood volume, such as gray matter, similar to changes seen in response to a breath-hold challenge. In addition, the respiration-variation-induced signal changes were found to coincide with many of the areas identified as part of the 'default mode' network, a set of brain regions hypothesized to be more active at rest. Regions could therefore be classified as being part of a resting network based on their similar respiration-induced changes rather than their synchronized neuronal activity. Monitoring and removing these respiration variations led to a significant improvement in the identification of task-related activation and deactivation and only slight differences in regions correlated with the posterior cingulate at rest. Regressing out global signal changes or cueing the subject to breathe at a constant rate and depth resulted in an improved spatial overlap between deactivations and resting-state correlations among areas that showed deactivation. JF - NeuroImage AU - Birn, Rasmus M AU - Diamond, Jason B AU - Smith, Monica A AU - Bandettini, Peter A AD - Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, 10 Center Dr., Bldg. 10, Rm. 1D80 Bethesda, MD 20892-1148, USA, rbirn@nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1536 EP - 1548 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neural networks KW - Functional magnetic resonance imaging KW - Respiration KW - Brain KW - Blood vessels KW - Deactivation KW - Substantia grisea KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19447137?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Separating+respiratory-variation-related+fluctuations+from+neuronal-+activity-related+fluctuations+in+fMRI&rft.au=Birn%2C+Rasmus+M%3BDiamond%2C+Jason+B%3BSmith%2C+Monica+A%3BBandettini%2C+Peter+A&rft.aulast=Birn&rft.aufirst=Rasmus&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1536&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.02.048 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Respiration; Functional magnetic resonance imaging; Deactivation; Substantia grisea; Blood vessels; Brain; Neural networks DO - http://dx.doi.org/10.1016/j.neuroimage.2006.02.048 ER - TY - JOUR T1 - The impact of affect and frequency on lexical decision: The role of the amygdala and inferior frontal cortex AN - 19446772; 6931190 AB - The current study used event-related fMRI to examine BOLD responses associated with two factors that behaviorally determine speed of lexical decision: frequency and emotion. Thirteen healthy adults performed a visual lexical decision task, discriminating between words and orthographically and phonologically legal nonwords. The study involved a 2 (Frequency: high and low) x 3 (Emotional arousal: highly negative, mildly negative, and neutral words) design with word categories matched for number of letters and concreteness. There were significant main effects for both frequency and emotion in lexical decision reaction times but no significant interaction. Negative word lexical decisions were associated with increased activation in bilateral amygdala and middle temporal cortex as well as rostral anterior and posterior cingulate cortex. Low-frequency word lexical decisions, relative to high-frequency word lexical decisions, were associated with increased bilateral activity in inferior frontal cortex. Inferior frontal cortex activation was particularly low during lexical decision for high-frequency emotional words but significant for high- frequency neutral emotional words. We suggest that this is because the semantic representation of high-frequency emotional words may receive sufficient additional augmentation via the reciprocal activation from the amygdala such that selective augmentation by inferior frontal cortex to achieve lexical decision is unnecessary. JF - NeuroImage AU - Nakic, Marina AU - Smith, Bruce W AU - Busis, Sarah AU - Vythilingam, Meena AU - Blair, RJames R AD - Unit on Affective Cognitive Neuroscience, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA, nakicm@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1752 EP - 1761 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Emotions KW - Arousal KW - Functional magnetic resonance imaging KW - Cortex (frontal) KW - Cortex (temporal) KW - Cortex (cingulate) KW - Decision making KW - Reaction time task KW - Cortex (visual) KW - Amygdala KW - Language KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446772?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=The+impact+of+affect+and+frequency+on+lexical+decision%3A+The+role+of+the+amygdala+and+inferior+frontal+cortex&rft.au=Nakic%2C+Marina%3BSmith%2C+Bruce+W%3BBusis%2C+Sarah%3BVythilingam%2C+Meena%3BBlair%2C+RJames+R&rft.aulast=Nakic&rft.aufirst=Marina&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1752&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.02.022 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Language; Emotions; Cortex (frontal); Cortex (cingulate); Cortex (temporal); Amygdala; Cortex (visual); Reaction time task; Arousal; Decision making; Functional magnetic resonance imaging DO - http://dx.doi.org/10.1016/j.neuroimage.2006.02.022 ER - TY - JOUR T1 - Brain abnormalities in human obesity: A voxel-based morphometric study AN - 19446314; 6931161 AB - Obesity is accompanied by damage to several tissues. Overweight is a risk factor for Alzheimer's disease and other neurodegenerative disorders. Whether structural abnormalities associated with excess body fat may also occur in the brain is unknown. We sought to determine to what extent excess body fat is associated with regional alterations in brain structure using voxel-based morphometry (VBM), a whole-brain unbiased technique based upon high-definition 3D magnetic resonance imaging (MRI) scans normalized into a common standard space and allowing for an objective assessment of neuroanatomical differences throughout the brain. We studied 24 obese (11 male, 13 female; age: 32 +/- 8 years; body mass index [BMI]: 39.4 +/- 4.7 kg/m super(2)) and 36 lean (25 male, 11 female; mean age: 33 +/- 9 years; BMI: 22.7 +/- 2.2 kg/m super(2)) non-diabetic Caucasians. In comparison with the group of lean subjects, the group of obese individuals had significantly lower gray matter density in the post-central gyrus, frontal operculum, putamen, and middle frontal gyrus (P - 0.01 after adjustment for sex, age, handedness, global tissue density, and multiple comparisons). BMI was negatively associated with GM density of the left post- central gyrus in obese but not lean subjects. This study identified structural brain differences in human obesity in several brain areas previously involved in the regulation of taste, reward, and behavioral control. These alterations may either precede obesity, representing a neural marker of increased propensity to gaining weight, or occur as a consequence of obesity, indicating that also the brain is affected by increased adiposity. JF - NeuroImage AU - Pannacciulli, Nicola AU - Del Parigi, Angelo AU - Chen, Kewei AU - Le, Duc Son NT AU - Reiman, Eric M AU - Tataranni, Pietro A AD - Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, 4212 N. 16th St., Rm. 5-28, Phoenix, AZ 85016, USA, nicolap@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1419 EP - 1425 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 4 SN - 1053-8119, 1053-8119 KW - Physical Education Index; CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Alzheimer's disease KW - Anatomy KW - Evaluation KW - Body weight KW - Weight KW - Sex KW - Handedness KW - Brain KW - Morphometry KW - Adipose tissue KW - Body fat KW - Body mass index KW - Substantia grisea KW - Body mass KW - Magnetic resonance imaging KW - Techniques KW - Putamen KW - Reward KW - Risk factors KW - Reinforcement KW - Brain architecture KW - frontal gyrus KW - Obesity KW - Taste KW - Neurodegenerative diseases KW - operculum KW - Scanning KW - W 30910:Imaging KW - N3 11027:Neurology & neuropathology KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19446314?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Brain+abnormalities+in+human+obesity%3A+A+voxel-based+morphometric+study&rft.au=Pannacciulli%2C+Nicola%3BDel+Parigi%2C+Angelo%3BChen%2C+Kewei%3BLe%2C+Duc+Son+NT%3BReiman%2C+Eric+M%3BTataranni%2C+Pietro+A&rft.aulast=Pannacciulli&rft.aufirst=Nicola&rft.date=2006-07-01&rft.volume=31&rft.issue=4&rft.spage=1419&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.01.047 LA - English DB - Physical Education Index; ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Obesity; Brain; Alzheimer's disease; Evaluation; Scanning; Techniques; Reward; Risk factors; Handedness; Sex; Weight; Body mass; Magnetic resonance imaging; Neurodegenerative diseases; Body fat; Brain architecture; Body mass index; Putamen; Taste; Reinforcement; operculum; frontal gyrus; Anatomy; Morphometry; Adipose tissue; Body weight; Substantia grisea DO - http://dx.doi.org/10.1016/j.neuroimage.2006.01.047 ER - TY - JOUR T1 - Language lateralization and the role of the fusiform gyrus in semantic processing in young children AN - 19439502; 6883365 AB - We used blood oxygen-dependent (BOLD) fMRI technique at 1.5 T to examine brain regions associated with language comprehension in normally developing children, age 5 to 10 years. Twenty-three children participated in the study using an auditory semantic decision task which varied in task difficulty. Analysis of individual participants' data showed patterns of activation largely consistent with previous neuroimaging findings in adult language processing. Group data analysis also showed a strong left-lateralized pattern of activation that closely resembles those typically observed in adults. In addition, significant activation in the left fusiform gyrus was observed and was associated with task accuracy. This finding suggests that auditory semantic processing in young children may recruit cortical regions associated with word reading in adults prior to the initiation of a semantic category decision, a process which is consistent with patterns of early word recognition process and language development. JF - NeuroImage AU - Balsamo, L M AU - Xu, B AU - Gaillard, W D AD - Department of Neurology, Children's National Medical Center, The George Washington University School of Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA, gaillardw@ninds.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1306 EP - 1314 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Neuroimaging KW - Hemispheric laterality KW - Data processing KW - Functional magnetic resonance imaging KW - Recruitment KW - Children KW - Decision making KW - Pattern recognition KW - Cortex KW - Information processing KW - Language KW - W 30910:Imaging KW - N3 11001:Behavioral and Cognitive Neuroscience UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19439502?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Language+lateralization+and+the+role+of+the+fusiform+gyrus+in+semantic+processing+in+young+children&rft.au=Balsamo%2C+L+M%3BXu%2C+B%3BGaillard%2C+W+D&rft.aulast=Balsamo&rft.aufirst=L&rft.date=2006-07-01&rft.volume=31&rft.issue=3&rft.spage=1306&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.01.027 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Language; Children; Information processing; Hemispheric laterality; Neuroimaging; Pattern recognition; Recruitment; Decision making; Cortex; Functional magnetic resonance imaging; Data processing DO - http://dx.doi.org/10.1016/j.neuroimage.2006.01.027 ER - TY - JOUR T1 - Resolution of complex tissue microarchitecture using the diffusion orientation transform (DOT) AN - 19437228; 6883345 AB - This article describes an accurate and fast method for fiber orientation mapping using multidirectional diffusion-weighted magnetic resonance (MR) data. This novel approach utilizes the Fourier transform relationship between the water displacement probabilities and diffusion-attenuated MR signal expressed in spherical coordinates. The radial part of the Fourier integral is evaluated analytically under the assumption that MR signal attenuates exponentially. The values of the resulting functions are evaluated at a fixed distance away from the origin. The spherical harmonic transform of these functions yields the Laplace series coefficients of the probabilities on a sphere of fixed radius. Alternatively, probability values can be computed nonparametrically using Legendre polynomials. Orientation maps calculated from excised rat nervous tissue data demonstrate this technique's ability to accurately resolve crossing fibers in anatomical regions such as the optic chiasm. This proposed methodology has a trivial extension to multiexponential diffusion-weighted signal decay. The developed methods will improve the reliability of tractography schemes and may make it possible to correctly identify the neural connections between functionally connected regions of the nervous system. JF - NeuroImage AU - Oezarslan, Evren AU - Shepherd, Timothy M AU - Vemuri, Baba C AU - Blackband, Stephen J AU - Mareci, Thomas H AD - Department of Computer and Information Science and Engineering, University of Florida, P.O. Box 116120, Gainesville, FL 32611, USA, evren@helix.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1086 EP - 1103 PB - Elsevier Science Ltd., The Boulevard Langford Lane Kidlington Oxford OX5 1GB UK, [mailto:usinfo-f@elsevier.com], [URL:http://www.elsevier.nl] VL - 31 IS - 3 SN - 1053-8119, 1053-8119 KW - CSA Neurosciences Abstracts; Biotechnology and Bioengineering Abstracts KW - Maps KW - Optic chiasm KW - Fibers KW - Nervous system KW - Diffusion KW - N.M.R. KW - Mapping KW - W 30910:Imaging KW - N3 11145:Methodology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19437228?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=NeuroImage&rft.atitle=Resolution+of+complex+tissue+microarchitecture+using+the+diffusion+orientation+transform+%28DOT%29&rft.au=Oezarslan%2C+Evren%3BShepherd%2C+Timothy+M%3BVemuri%2C+Baba+C%3BBlackband%2C+Stephen+J%3BMareci%2C+Thomas+H&rft.aulast=Oezarslan&rft.aufirst=Evren&rft.date=2006-07-01&rft.volume=31&rft.issue=3&rft.spage=1086&rft.isbn=&rft.btitle=&rft.title=NeuroImage&rft.issn=10538119&rft_id=info:doi/10.1016%2Fj.neuroimage.2006.01.024 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2007-01-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Fibers; N.M.R.; Mapping; Optic chiasm; Maps; Nervous system; Diffusion DO - http://dx.doi.org/10.1016/j.neuroimage.2006.01.024 ER - TY - JOUR T1 - Serum Concentrations of 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and 1,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and Risk of Primary Liver Cancer AN - 19367881; 7129144 AB - BACKGROUND: 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) exposure has been demonstrated to cause liver tumors in laboratory rodents. DDT's persistent metabolite and environmental degradation product, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also been associated with liver tumors in laboratory animals. Whether DDT and DDE are associated with hepatocarcinogenesis in humans is not clear. METHODS: We carried out a nested case-control study among the participants of the Nutritional Intervention Trials in Linxian, China. The case group included 168 individuals who developed liver cancer during the trials, and the control group included 385 individuals frequency-matched on age and sex who were alive and well at the end of the study. Serum concentrations of DDT and DDE were measured by gas chromatography-mass spectrometry. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable analysis. RESULTS: In multivariable-adjusted models, the risk of developing liver cancer increased with increased serum DDT concentration (OR for quintile 1 versus quintile 5 = 3.8, 95% CI = 1.7 to 8.6, P sub(trend) = .0024). In contrast, there was no statistically significant association between liver cancer and serum DDE concentration. The association between high serum DDT concentration and liver cancer was stronger among individuals with DDE concentrations below the median value (odds ratio for tertile 3 versus tertile 1 = 3.55, 95% CI = 1.45 to 8.74) than those with concentrations above the median (OR = 1.70, 95% CI = 0.97 to 2.98). A calculation of crude liver cancer risk found that there would be 26 liver cancers per 100 000 persons per year in the lowest quintile of DDT exposure versus 46 liver cancers per 100 000 persons per year in the highest quintile of DDT exposure. CONCLUSIONS: DDT may be a risk factor for liver cancer, particularly among persons with lower DDE concentrations. Risk may be particularly increased among persons exposed directly to DDT (resulting in a higher ratio of DDT to DDE) or, alternatively, risk may be associated with individual ability to metabolize DDT to DDE. JF - Journal of the National Cancer Institute AU - McGlynn, Katherine A AU - Abnet, Christian C AU - Zhang, Mingdong AU - Sun, Xiu-Di AU - Fan, Jin-Hu AU - O'Brien, Thomas R AU - Wei, Wen-Qiang AU - Ortiz-Conde, Betty A AU - Dawsey, Sanford M AU - Weber, Jean-Philippe AU - Taylor, Philip R AU - Katki, Hormuzd AU - Mark, Steven D AU - Qiao, You-Lin AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD (KAM, CCA, MZ, TRO, SMD, PRT, HK, SDM) Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1005 EP - 1010 PB - Oxford University Press, Oxford Journals, Great Clarendon Street Oxford OX2 6DP UK, [mailto:jnl.samples@oup.co.uk], [URL:http://www3.oup.co.uk/jnls/] VL - 98 IS - 14 SN - 0027-8874, 0027-8874 KW - Risk Abstracts; Toxicology Abstracts KW - Environmental degradation KW - Liver cancer KW - DDE KW - Laboratory animals KW - Statistical analysis KW - Metabolites KW - Tumors KW - Cancer KW - Mass spectroscopy KW - Spectrometry KW - Models KW - Insecticides KW - Nitrous oxide KW - Gas chromatography KW - Risk factors KW - DDT KW - Liver KW - China, People's Rep. KW - R2 23060:Medical and environmental health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19367881?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+the+National+Cancer+Institute&rft.atitle=Serum+Concentrations+of+1%2C1%2C1-Trichloro-2%2C2-bis%28p-chlorophenyl%29ethane+%28DDT%29+and+1%2C1-Dichloro-2%2C2-bis%28p-chlorophenyl%29ethylene+%28DDE%29+and+Risk+of+Primary+Liver+Cancer&rft.au=McGlynn%2C+Katherine+A%3BAbnet%2C+Christian+C%3BZhang%2C+Mingdong%3BSun%2C+Xiu-Di%3BFan%2C+Jin-Hu%3BO%27Brien%2C+Thomas+R%3BWei%2C+Wen-Qiang%3BOrtiz-Conde%2C+Betty+A%3BDawsey%2C+Sanford+M%3BWeber%2C+Jean-Philippe%3BTaylor%2C+Philip+R%3BKatki%2C+Hormuzd%3BMark%2C+Steven+D%3BQiao%2C+You-Lin&rft.aulast=McGlynn&rft.aufirst=Katherine&rft.date=2006-07-01&rft.volume=98&rft.issue=14&rft.spage=1005&rft.isbn=&rft.btitle=&rft.title=Journal+of+the+National+Cancer+Institute&rft.issn=00278874&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Environmental degradation; Gas chromatography; Risk factors; Liver cancer; DDE; DDT; Statistical analysis; Laboratory animals; Metabolites; Tumors; Mass spectroscopy; Models; Insecticides; Nitrous oxide; Liver; Cancer; Spectrometry; China, People's Rep. ER - TY - JOUR T1 - NMR Structure of AbhN and Comparison with AbrBN: FIRST INSIGHTS INTO THE DNA BINDING PROMISCUITY AND SPECIFICITY OF AbrB-LIKE TRANSITION STATE REGULATOR PROTEINS AN - 19366074; 7128841 AB - Understanding the molecular mechanisms of transition state regulator proteins is critical, since they play a pivotal role in the ability of bacteria to cope with changing environments. Although much effort has focused on their genetic characterization, little is known about their structural and functional conservation. Here we present the high resolution NMR solution structure of the N-terminal domain of the Bacillus subtilis transition state regulator Abh (AbhN), only the second such structure to date. We then compare AbhN to the N-terminal DNA-binding domain of B. subtilis AbrB (AbrBN). This is the first such comparison between two AbrB-like transition state regulators. AbhN and AbrBN are very similar, suggesting a common structural basis for their DNA binding. However, we also note subtle variances between the AbhN and AbrBN structures, which may play important roles in DNA target specificity. The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins. JF - Journal of Biological Chemistry AU - Bobay, Benjamin G AU - Mueller, Geoffrey A AU - Thompson, Richele J AU - Murzin, Alexey G AU - Venters, Ronald A AU - Strauch, Mark A AU - Cavanagh, John AD - Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, North Carolina 27695, the Laboratory of Structural Biology, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, Medical Research Council Centre for Protein Engineering, Hills Road, Cambridge CB2 2QH, United Kingdom, the Duke University NMR Center, Durham, North Carolina 27710, and the Biomedical Sciences Department, Dental School, University of Maryland, Baltimore, Maryland 21201 Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 21399 EP - 21409 PB - American Society for Biochemistry and Molecular Biology, 9650 Rockville Pike Bethesda MD 20814-3996 USA, [mailto:asbmb@asbmb.faseb.org], [URL:http://www.jbc.org] VL - 281 IS - 30 SN - 0021-9258, 0021-9258 KW - Microbiology Abstracts B: Bacteriology; Biochemistry Abstracts 2: Nucleic Acids KW - Molecular modelling KW - Bacillus subtilis KW - Structure-function relationships KW - DNA KW - N.M.R. KW - J 02310:Genetics & Taxonomy KW - N 14825:Gene Regulation UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19366074?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Biological+Chemistry&rft.atitle=NMR+Structure+of+AbhN+and+Comparison+with+AbrBN%3A+FIRST+INSIGHTS+INTO+THE+DNA+BINDING+PROMISCUITY+AND+SPECIFICITY+OF+AbrB-LIKE+TRANSITION+STATE+REGULATOR+PROTEINS&rft.au=Bobay%2C+Benjamin+G%3BMueller%2C+Geoffrey+A%3BThompson%2C+Richele+J%3BMurzin%2C+Alexey+G%3BVenters%2C+Ronald+A%3BStrauch%2C+Mark+A%3BCavanagh%2C+John&rft.aulast=Bobay&rft.aufirst=Benjamin&rft.date=2006-07-01&rft.volume=281&rft.issue=30&rft.spage=21399&rft.isbn=&rft.btitle=&rft.title=Journal+of+Biological+Chemistry&rft.issn=00219258&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Molecular modelling; Structure-function relationships; DNA; N.M.R.; Bacillus subtilis ER - TY - JOUR T1 - Chondrocyte Phenotype in Engineered Fibrous Matrix Is Regulated by Fiber Size AN - 19338512; 7086302 AB - A biomaterial scaffold acting as a functional substitute for the native extracellular matrix provides space for cell accommodation. In this study, we seeded chondrocytes, isolated from 4- to 6-month-old calves, in 2 types of poly(L-lactide) scaffolds, composed of micro- and nanofibers, and compared the effects on cellular activities. Scanning electron microscopy revealed a well-spread morphology for chondrocytes grown on microfibers. In contrast, chondrocytes on the nanofibers were found to have a rounded morphology and displayed a disorganized actin cytoskeletal structure compared to the organized cytoske-leton seen in well-spread chondrocytes culture on the microfibrous scaffold. Both scaffolds supported chondrocyte proliferation, with a higher rate seen in cultures in nanofibrous scaffold. Quantitative reverse transcription-polymerase chain reaction analysis showed that both cultures supported expression of collagen types I and II and aggrecan. Biochemical analysis showed a higher level of sulfated glyco-saminoglycan in the nanofiber culture, confirmed by more intense alcian blue histologic staining. The nanofiber cultures also showed higher immunostaining for collagen types II and IX, aggrecan, and cartilage proteoglycan link protein. Based on these results, we conclude that chondrocytes respond differently to fibrous scaffolds of varying diameters, and that the scaffolds made of nanofibrous biomaterial promote efficient cell-based cartilage tissue engineering. JF - Tissue Engineering AU - Li, W-J AU - Jiang, Y J AU - Tuan, R S AD - Cartilage Biology and Orthopaedics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Building 50, Room 1503, MSC 8022 Bethesda, MD 20892-8022, USA, tuanr@mail.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1775 EP - 1785 VL - 12 IS - 7 SN - 1076-3279, 1076-3279 KW - Biotechnology and Bioengineering Abstracts; Bioengineering Abstracts; Medical and Pharmaceutical Biotechnology Abstracts KW - Cartilage KW - Biochemical analysis KW - Chondrocytes KW - Cell culture KW - Collagen KW - Cytoskeleton KW - Actin KW - Scanning electron microscopy KW - Tissue engineering KW - scaffolds KW - Proteoglycans KW - Fibers KW - Extracellular matrix KW - Biomaterials KW - aggrecan KW - W 30965:Miscellaneous, Reviews KW - W4 110:Biomedical Materials & Tissue Engineering KW - W3 33055:Genetic engineering (general) UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/19338512?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Tissue+Engineering&rft.atitle=Chondrocyte+Phenotype+in+Engineered+Fibrous+Matrix+Is+Regulated+by+Fiber+Size&rft.au=Li%2C+W-J%3BJiang%2C+Y+J%3BTuan%2C+R+S&rft.aulast=Li&rft.aufirst=W-J&rft.date=2006-07-01&rft.volume=12&rft.issue=7&rft.spage=1775&rft.isbn=&rft.btitle=&rft.title=Tissue+Engineering&rft.issn=10763279&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Chondrocytes; scaffolds; Cell culture; Collagen; Biomaterials; Tissue engineering; Cartilage; aggrecan; Proteoglycans; Biochemical analysis; Actin; Cytoskeleton; Scanning electron microscopy; Extracellular matrix; Fibers ER - TY - JOUR T1 - Daily Activity Energy Expenditure and Mortality Among Older Adults AN - 17274354; 6996125 AB - CONTEXT: Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages. OBJECTIVE: To determine whether free-living activity energy expenditure is associated with all-cause mortality among older adults. Design, Setting, and Participants Free-living activity energy expenditure was assessed in 302 high-functioning, community-dwelling older adults (aged 70-82 years). Total energy expenditure was assessed over 2 weeks using doubly labeled water. Resting metabolic rate was measured using indirect calorimetry and the thermic effect of meals was estimated at 10% of total energy expenditure. Free-living activity energy expenditure was calculated as: (total energy expenditure x 0.90) - resting metabolic rate. Participants were followed up over a mean of 6.15 years (1998-2006). MAIN OUTCOME MEASURES: Free-living activity energy expenditure (3 tertiles: low, 770 kcal/d) and all-cause mortality. RESULTS: Fifty-five participants (18.2%) died during follow-up. As a continuous risk factor, an SD increase in free-living activity energy expenditure (287 kcal/d) was associated with a 32% lower risk of mortality after adjusting for age, sex, race, study site, weight, height, percentage of body fat, and sleep duration (hazard ratio, 0.68; 95% confidence interval, 0.48-0.96). Using the same adjustments, individuals in the highest tertile of free-living activity energy expenditure were at a significantly lower mortality risk compared with the lowest tertile (hazard ratio, 0.31; 95% confidence interval, 0.14-0.69). Absolute risk of death was 12.1% in the highest tertile of activity energy expenditure vs 24.7% in the lowest tertile; absolute risks were similar to these for tertiles of physical activity level. The effect of free-living activity energy expenditure changed little after further adjustment for self-rated health, education, prevalent health conditions, and smoking behavior. According to self-reports, individuals expending higher levels of free-living activity energy were more likely to work for pay (P = .004) and climb stairs (P = .01) but self-reported high-intensity exercise, walking for exercise, walking other than for exercise, volunteering, and caregiving did not differ significantly across the activity energy expenditure tertiles. CONCLUSIONS: Objectively measured free-living activity energy expenditure was strongly associated with lower risk of mortality in healthy older adults. Simply expending energy through any activity may influence survival in older adults. JF - JAMA: Journal of the American Medical Association AU - Manini, Todd M AU - Everhart, James E AU - Patel, Kushang V AU - Schoeller, Dale A AU - Colbert, Lisa H AU - Visser, Marjolein AU - Tylavsky, Frances AU - Bauer, Douglas C AU - Goodpaster, Bret H AU - Harris, Tamara B AD - National Institute on Aging, Laboratory of Epidemiology, Demography and Biometry (Drs Manini, Patel, and Harris) and National Institute of Diabetes and Digestive and Kidney Diseases (Dr Everhart), Bethesda, Md Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 171 EP - 179 PB - American Medical Association, 515 N. State St. Chicago IL 60610 USA VL - 296 IS - 2 SN - 0098-7484, 0098-7484 KW - Physical Education Index KW - Measurement KW - Death KW - Gerontology KW - Height KW - Walking KW - Health (behavior) KW - Work KW - Basal metabolic rate KW - Exercise KW - Adults KW - Energy cost KW - Smoking KW - Weight KW - Sleep KW - Risk factors KW - AMA KW - Calorimetry KW - Sex KW - PE 030:Exercise, Health & Physical Fitness UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17274354?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Aphysicaleducation&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=JAMA%3A+Journal+of+the+American+Medical+Association&rft.atitle=Daily+Activity+Energy+Expenditure+and+Mortality+Among+Older+Adults&rft.au=Manini%2C+Todd+M%3BEverhart%2C+James+E%3BPatel%2C+Kushang+V%3BSchoeller%2C+Dale+A%3BColbert%2C+Lisa+H%3BVisser%2C+Marjolein%3BTylavsky%2C+Frances%3BBauer%2C+Douglas+C%3BGoodpaster%2C+Bret+H%3BHarris%2C+Tamara+B&rft.aulast=Manini&rft.aufirst=Todd&rft.date=2006-07-01&rft.volume=296&rft.issue=2&rft.spage=171&rft.isbn=&rft.btitle=&rft.title=JAMA%3A+Journal+of+the+American+Medical+Association&rft.issn=00987484&rft_id=info:doi/ LA - English DB - Physical Education Index N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Measurement; Death; Gerontology; Work; Health (behavior); Walking; Height; Basal metabolic rate; Adults; Exercise; Energy cost; Smoking; Weight; Risk factors; Sleep; AMA; Calorimetry; Sex ER - TY - JOUR T1 - DNase-chip: a high-resolution method to identify DNase I hypersensitive sites using tiled microarrays AN - 17265086; 6964077 AB - Mapping DNase I hypersensitive sites is an accurate method of identifying the location of gene regulatory elements, including promoters, enhancers, silencers and locus control regions. Although Southern blots are the traditional method of identifying DNase I hypersensitive sites, the conventional manual method is not readily scalable to studying large chromosomal regions, much less the entire genome. Here we describe DNase-chip, an approach that can rapidly identify DNase I hypersensitive sites for any region of interest, or potentially for the entire genome, by using tiled microarrays. We used DNase-chip to identify DNase I hypersensitive sites accurately from a representative 1% of the human genome in both primary and immortalized cell types. We found that although most DNase I hypersensitive sites were present in both cell types studied, some of them were cell-type specific. This method can be applied globally or in a targeted fashion to any tissue from any species with a sequenced genome. JF - Nature Methods AU - Crawford, Gregory E AU - Davis, Sean AU - Scacheri, Peter C AU - Renaud, Gabriel AU - Halawi, Mohamad J AU - Erdos, Michael R AU - Green, Roland AU - Meltzer, Paul S AU - Wolfsberg, Tyra G AU - Collins, Francis S AD - National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, Bethesda, Maryland 20892, USA., francisc@exchange.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 503 EP - 509 PB - Nature Publishing Group, The Macmillan Building 4 Crinan Street London N1 9XW UK, [mailto:feedback@nature.com], [URL:http://www.nature.com/] VL - 3 IS - 7 SN - 1548-7091, 1548-7091 KW - Biochemistry Abstracts 2: Nucleic Acids; Biotechnology and Bioengineering Abstracts KW - Genomes KW - Regulatory sequences KW - DNA microarrays KW - Enhancers KW - Promoters KW - Deoxyribonuclease KW - Gene mapping KW - N 14810:Methods KW - W 30900:Methods UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17265086?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Abiotechresearch&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Nature+Methods&rft.atitle=DNase-chip%3A+a+high-resolution+method+to+identify+DNase+I+hypersensitive+sites+using+tiled+microarrays&rft.au=Crawford%2C+Gregory+E%3BDavis%2C+Sean%3BScacheri%2C+Peter+C%3BRenaud%2C+Gabriel%3BHalawi%2C+Mohamad+J%3BErdos%2C+Michael+R%3BGreen%2C+Roland%3BMeltzer%2C+Paul+S%3BWolfsberg%2C+Tyra+G%3BCollins%2C+Francis+S&rft.aulast=Crawford&rft.aufirst=Gregory&rft.date=2006-07-01&rft.volume=3&rft.issue=7&rft.spage=503&rft.isbn=&rft.btitle=&rft.title=Nature+Methods&rft.issn=15487091&rft_id=info:doi/10.1038%2Fnmeth888 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2011-12-13 N1 - SubjectsTermNotLitGenreText - Deoxyribonuclease; Genomes; DNA microarrays; Regulatory sequences; Promoters; Gene mapping; Enhancers DO - http://dx.doi.org/10.1038/nmeth888 ER - TY - JOUR T1 - High Dry Bean Intake and Reduced Risk of Advanced Colorectal Adenoma Recurrence among Participants in the Polyp Prevention Trial AN - 17263463; 6998327 AB - Adequate fruit and vegetable intake was suggested to protect against colorectal cancer and colorectal adenomas; however, several recent prospective studies reported no association. We examined the association between fruits and vegetables and adenomatous polyp recurrence in the Polyp Prevention Trial (PPT). The PPT was a low-fat, high-fiber, high-fruit, and vegetable dietary intervention trial of adenoma recurrence, in which there were no differences in the rate of adenoma recurrence in participants in the intervention and control arms of the trial. In this analysis of the entire PPT trial-based cohort, multiple logistic regression analysis was used to estimate the odds ratio (OR) of advanced and nonadvanced adenoma recurrence within quartiles of baseline and change (baseline minus the mean over 3 y) in fruit and vegetable intake, after adjustment for age, total energyy intake, use of nonsteroidal anti-inflammatory drugs, BMI, and gender. There were no significant associations between nonadvanced adenoma recurrence and overall change in fruit and vegetable consumption; however, those in the highest quartile of change in dry bean intake (greatest increase) compared with those in the lowest had a significantly reduced OR for advanced adenoma recurrence (OR = 0.35; 95% CI, 0.18-0.69; P for trend = 0.001). The median in the highest quartile of change in dry bean intake was 370% higher than the baseline intake. The PPT trial-based cohort provides evidence that dry beans may be inversely associated with advanced adenoma recurrence. JF - Journal of Nutrition AU - Lanza, Elaine AU - Hartman, Terryl J AU - Albert, Paul S AU - Shields, Rusty AU - Slattery, Martha AU - Caan, Bette AU - Paskett, Electra AU - Iber, Frank AU - Kikendall, James Walter AU - Lance, Peter AU - Daston, Cassandra AU - Schatzkin, Arthur AD - Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Bethesda, MD Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 1896 EP - 1903 PB - American Society for Nutritional Sciences, 9650 Rockville Pike, Room L-2407A Bethesda MD 20814 USA, [mailto:staff@faseb.org], [URL:http://www.nutrition.org] VL - 136 IS - 7 SN - 0022-3166, 0022-3166 KW - colorectal carcinoma KW - Risk Abstracts KW - Diets KW - Gender KW - prevention KW - Nutrition KW - Cancer KW - R2 23060:Medical and environmental health UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17263463?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Ariskabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Nutrition&rft.atitle=High+Dry+Bean+Intake+and+Reduced+Risk+of+Advanced+Colorectal+Adenoma+Recurrence+among+Participants+in+the+Polyp+Prevention+Trial&rft.au=Lanza%2C+Elaine%3BHartman%2C+Terryl+J%3BAlbert%2C+Paul+S%3BShields%2C+Rusty%3BSlattery%2C+Martha%3BCaan%2C+Bette%3BPaskett%2C+Electra%3BIber%2C+Frank%3BKikendall%2C+James+Walter%3BLance%2C+Peter%3BDaston%2C+Cassandra%3BSchatzkin%2C+Arthur&rft.aulast=Lanza&rft.aufirst=Elaine&rft.date=2006-07-01&rft.volume=136&rft.issue=7&rft.spage=1896&rft.isbn=&rft.btitle=&rft.title=Journal+of+Nutrition&rft.issn=00223166&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Diets; Gender; prevention; Nutrition; Cancer ER - TY - JOUR T1 - External Dose Estimation for Nuclear Worker Studies AN - 17257241; 7002777 AB - Epidemiological studies of nuclear workers are an important source of direct information on the health effects of exposure to radiation at low doses and low dose rates. These studies have the important advantage of doses that have been measured objectively through the use of personal dosimeters. However, to make valid comparisons of worker-based estimates with those obtained from data on A-bomb survivors or persons exposed for medical reasons, attention must be given to potential biases and uncertainties in dose estimates. This paper discusses sources of error in worker dose estimates and describes efforts that have been made to quantify these errors. Of particular importance is the extensive study of errors in dosimetry that was conducted as part of a large collaborative study of nuclear workers in 15 countries being coordinated by the International Agency for Research on Cancer. The study, which focused on workers whose dose was primarily from penetrating gamma radiation in the range 100 keV to 3 MeV, included (1) obtaining information on dosimetry practices and radiation characteristics through the use of questionnaires; (2) two detailed studies of exposure conditions, one of nuclear power plants and the other of mixed activity facilities; and (3) a study of dosimeter response characteristics that included laboratory testing of 10 dosimeter designs commonly used historically. Based on these efforts, facility- and calendar year-specific adjustment factors have been developed, which will allow risks to be expressed as functions of organ doses with reasonable confidence. JF - Radiation Research AU - Gilbert, E S AU - Thierry-Chef, I AU - Cardis, E AU - Fix, J J AU - Marshall, M AD - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 168 EP - 173 PB - Radiation Research Society VL - 166 IS - 1 SN - 0033-7587, 0033-7587 KW - Toxicology Abstracts KW - Workers KW - Inventories KW - Nuclear power plants KW - Dosimetry KW - gamma Radiation KW - Occupational exposure KW - Cancer KW - X 24390:Radioactive Materials UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17257241?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Radiation+Research&rft.atitle=External+Dose+Estimation+for+Nuclear+Worker+Studies&rft.au=Gilbert%2C+E+S%3BThierry-Chef%2C+I%3BCardis%2C+E%3BFix%2C+J+J%3BMarshall%2C+M&rft.aulast=Gilbert&rft.aufirst=E&rft.date=2006-07-01&rft.volume=166&rft.issue=1&rft.spage=168&rft.isbn=&rft.btitle=&rft.title=Radiation+Research&rft.issn=00337587&rft_id=info:doi/10.1667%2FRR3126.1 L2 - http://journals.allenpress.com/jrnlserv/?request=get-abstract&issn=0033-7587&volume=166&issue=1&page=168 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-12-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Nuclear power plants; Inventories; Workers; Dosimetry; gamma Radiation; Cancer; Occupational exposure DO - http://dx.doi.org/10.1667/RR3126.1 ER - TY - JOUR T1 - Fertility and exposure to solvents among families in the Agricultural Health Study AN - 17257239; 6998394 AB - BACKGROUND: Several studies have reported associations between solvent exposure and reduced female fertility, but the evidence is inconclusive for male fertility. OBJECTIVES: To investigate the impact of solvent exposure on subfertility among families of male licensed pesticide applicators in the Agricultural Health Study cohort. METHODS: The couples enrolled between 1993 and 1997. Cross-sectional questionnaire information on work tasks was used to assess exposure to solvents. The data were limited to couples (wife aged less than 40 years) with an attempt at pregnancy in the last four years (n = 2112). RESULTS: Twenty eight per cent of the couples were defined as subfertile (not conceiving a pregnancy after at least 12 months of unprotected intercourse, regardless of whether or not a pregnancy ultimately occurred). Adjusted subfertility odds ratios (OR) for exposure to solvents were calculated with logistic regression. Female (OR 1.42, 95% CI 1.15 to 1.75) and male exposure to solvents (OR 1.21 (95% CI 0.93 to 1.57) for monthly exposure and 1.40 (95% CI 0.97 to 2.03) for daily or weekly exposure) were associated with subfertility. In farming, spouses may share or exchange jobs. To account for potential dual exposure, variables for parental exposure (either parent exposed or both parents exposed) were also defined. Both were strongly associated with subfertility (OR 1.62 (95% CI 1.20 to 2.17) and OR 2.10 (95% CI 1.22 to 3.60), respectively). CONCLUSIONS: Solvents may impair fertility of either gender, though the evidence for female effects is stronger than for male effects. JF - Occupational and Environmental Medicine AU - Sallmen, M AU - Baird, D D AU - Hoppin, J A AU - Blair, A AU - Sandler, D P AD - Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Human Health Services, Research Triangle Park, North Carolina, USA Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 469 EP - 475 PB - B M J Publishing Group, B.M.A. House Tavistock Sq. London WC1H 9JR UK VL - 63 IS - 7 SN - 1351-0711, 1351-0711 KW - Health & Safety Science Abstracts; Toxicology Abstracts KW - Inventories KW - Fertility KW - Solvents KW - Agrochemicals KW - Pregnancy KW - Gender KW - Pesticides KW - Occupational exposure KW - H 1000:Occupational Safety and Health KW - X 24330:Agrochemicals UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17257239?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Atoxicologyabstracts&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Occupational+and+Environmental+Medicine&rft.atitle=Fertility+and+exposure+to+solvents+among+families+in+the+Agricultural+Health+Study&rft.au=Sallmen%2C+M%3BBaird%2C+D+D%3BHoppin%2C+J+A%3BBlair%2C+A%3BSandler%2C+D+P&rft.aulast=Sallmen&rft.aufirst=M&rft.date=2006-07-01&rft.volume=63&rft.issue=7&rft.spage=469&rft.isbn=&rft.btitle=&rft.title=Occupational+and+Environmental+Medicine&rft.issn=13510711&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-08-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Inventories; Fertility; Pesticides; Solvents; Pregnancy; Gender; Agrochemicals; Occupational exposure ER - TY - JOUR T1 - Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses AN - 17257012; 6997879 AB - Marburg virus (MARV) and Ebola virus (EBOV), members of the viral family Filoviridae, cause fatal hemorrhagic fevers in humans and nonhuman primates. High viral burden is coincident with inadequate adaptive immune responses and robust inflammatory responses, and virus-mediated dysregulation of early host defenses has been proposed. Recently, a novel class of innate receptors called the triggering receptors expressed in myeloid cells (TREM) has been discovered and shown to play an important role in innate inflammatory responses and sepsis. Here, we report that MARV and EBOV activate TREM-1 on human neutrophils, resulting in DAP12 phosphorylation, TREM-1 shedding, mobilization of intracellular calcium, secretion of proinflammatory cytokines, and phenotypic changes. A peptide specific to TREM-1 diminished the release of tumor necrosis factor alpha by filovirus-activated human neutrophils in vitro, and a soluble recombinant TREM-1 competitively inhibited the loss of cell surface TREM-1 that otherwise occurred on neutrophils exposed to filoviruses. These data imply direct activation of TREM-1 by filoviruses and also indicate that neutrophils may play a prominent role in the immune and inflammatory responses to filovirus infections. JF - Journal of Virology AU - Mohamadzadeh, Mansour AU - Coberley, Sadie S AU - Olinger, Gene G AU - Kalina, Warren V AU - Ruthel, Gordon AU - Fuller, Claudette L AU - Swenson, Dana L AU - Pratt, William D AU - Kuhns, Douglas B AU - Schmaljohn, Alan L AD - U.S. Army Medical Research Institute for Infectious Diseases, Frederick, Maryland. National Cancer Institute, Frederick, Maryland Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 7235 EP - 7244 PB - American Society for Microbiology, 1752 N Street N.W. Washington, DC 20036 USA, [URL:http://www.asm.org/] VL - 80 IS - 14 SN - 0022-538X, 0022-538X KW - Microbiology Abstracts B: Bacteriology; Immunology Abstracts; Virology & AIDS Abstracts KW - Cell surface KW - Marburg virus KW - Data processing KW - Leukocytes (neutrophilic) KW - Ebola virus KW - Infection KW - Myeloid cells KW - Primates KW - Calcium (intracellular) KW - DAP12 protein KW - Cell activation KW - Inflammation KW - Sepsis KW - Phosphorylation KW - Filovirus KW - Cytokines KW - Hemorrhagic fever KW - Tumor necrosis factor- alpha KW - Immune response KW - Filoviridae KW - J 02350:Immunology KW - F 06104:Virus KW - V 22370:Oncology UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17257012?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=Journal+of+Virology&rft.atitle=Activation+of+Triggering+Receptor+Expressed+on+Myeloid+Cells-1+on+Human+Neutrophils+by+Marburg+and+Ebola+Viruses&rft.au=Mohamadzadeh%2C+Mansour%3BCoberley%2C+Sadie+S%3BOlinger%2C+Gene+G%3BKalina%2C+Warren+V%3BRuthel%2C+Gordon%3BFuller%2C+Claudette+L%3BSwenson%2C+Dana+L%3BPratt%2C+William+D%3BKuhns%2C+Douglas+B%3BSchmaljohn%2C+Alan+L&rft.aulast=Mohamadzadeh&rft.aufirst=Mansour&rft.date=2006-07-01&rft.volume=80&rft.issue=14&rft.spage=7235&rft.isbn=&rft.btitle=&rft.title=Journal+of+Virology&rft.issn=0022538X&rft_id=info:doi/ LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-10-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Cell surface; Data processing; Leukocytes (neutrophilic); Myeloid cells; Infection; Inflammation; Cell activation; DAP12 protein; Calcium (intracellular); Sepsis; Phosphorylation; Hemorrhagic fever; Cytokines; Immune response; Tumor necrosis factor- alpha; Marburg virus; Filovirus; Ebola virus; Primates; Filoviridae ER - TY - JOUR T1 - Towards establishing a method to screen for inhibitors of essential genes in mycobacteria: evaluation of the acetamidase promoter AN - 17233067; 6930542 AB - As a successful pathogen, Mycobacterium tuberculosis has effectively infected one-third of the world's population. Despite the existence of compound libraries developed by recent advances in combinatorial chemistry, few compounds have been screened against M. tuberculosis. The use of a regulable promoter to control the level of expression of a drug target in living organisms has been shown to be advantageous compared with targetless whole-cell-based or in vitro biochemical screening approaches towards antibiotic discovery. In this study, we demonstrate that the acetamidase promoter from Mycobacterium smegmatis responds in a dose-dependent manner to different concentrations of its inducer acetamide. Using this promoter to regulate expression of a zeocin resistance gene in M. smegmatis, we show that the test strain exhibits increased sensitivity to zeocin at a low concentration of acetamide compared with a fully resistant phenotype at high doses of the inducer. This model system has indicated the feasibility of using a regulable promoter in designing a whole- cell-based high throughput screen for specific inhibitors against potential drug targets of M. tuberculosis. JF - International Journal of Antimicrobial Agents AU - Raghunand, Tirumalai R AU - Bishai, William R AU - Chen, Ping AD - Center for Tuberculosis Research, Department of Medicine, The Johns Hopkins University, School of Medicine, Baltimore, MD 21231-1001, USA, chenpi@niaid.nih.gov Y1 - 2006/07// PY - 2006 DA - Jul 2006 SP - 36 EP - 41 PB - Elsevier Science B.V., P.O. Box 211 Amsterdam 1000 AE Netherlands, [mailto:nlinfo-f@elsevier.nl], [URL:http://www.elsevier.nl/] VL - 28 IS - 1 SN - 0924-8579, 0924-8579 KW - Genetics Abstracts; Microbiology Abstracts B: Bacteriology KW - Mycobacterium tuberculosis KW - Acetamidase promoter KW - Dose-response KW - Inhibitors KW - Dose dependency KW - Promoters KW - Combinatorial chemistry KW - Tuberculosis KW - Antibiotics KW - Pathogens KW - Drugs KW - Mycobacterium smegmatis KW - Antimicrobial agents KW - J 02310:Genetics & Taxonomy KW - G 07770:Bacteria UR - http://libproxy.lib.unc.edu/login?url=http://search.proquest.com/docview/17233067?accountid=14244 L2 - http://vb3lk7eb4t.search.serialssolutions.com/?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&rfr_id=info:sid/ProQ%3Amicrobiologyb&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.jtitle=International+Journal+of+Antimicrobial+Agents&rft.atitle=Towards+establishing+a+method+to+screen+for+inhibitors+of+essential+genes+in+mycobacteria%3A+evaluation+of+the+acetamidase+promoter&rft.au=Raghunand%2C+Tirumalai+R%3BBishai%2C+William+R%3BChen%2C+Ping&rft.aulast=Raghunand&rft.aufirst=Tirumalai&rft.date=2006-07-01&rft.volume=28&rft.issue=1&rft.spage=36&rft.isbn=&rft.btitle=&rft.title=International+Journal+of+Antimicrobial+Agents&rft.issn=09248579&rft_id=info:doi/10.1016%2Fj.ijantimicag.2006.01.012 LA - English DB - ProQuest Environmental Science Collection N1 - Date revised - 2006-07-01 N1 - Last updated - 2015-03-25 N1 - SubjectsTermNotLitGenreText - Promoters; Dose dependency; Combinatorial chemistry; Antibiotics; Tuberculosis; Pathogens; Drugs; Antimicrobial agents; Mycobacterium tuberculosis; Mycobacterium smegmatis DO - http://dx.doi.org/10.1016/j.ijantimicag.2006.01.012 ER -